ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 305/6410 495/18639 0.616161616161616 1.79167493972486 5.79441937570116e-36 7.89779360908068e-33 GO:0140097 catalytic activity, acting on DNA 201/6410 336/18639 0.598214285714286 1.73948768665032 7.50612927583577e-22 5.11542710148208e-19 GO:0008094 ATP-dependent activity, acting on DNA 138/6410 210/18639 0.657142857142857 1.91084020503677 1.44035080854231e-20 6.54399384014389e-18 GO:0003713 transcription coactivator activity 160/6410 256/18639 0.625 1.8173751950078 2.58676171242745e-20 8.81439053509654e-18 GO:0140658 ATP-dependent chromatin remodeler activity 109/6410 158/18639 0.689873417721519 2.00601413929975 6.12045053598483e-19 1.66843481610947e-16 GO:0019787 ubiquitin-like protein transferase activity 257/6410 479/18639 0.536534446764092 1.56013503170607 1.72320112170652e-18 3.65673301668979e-16 GO:0042393 histone binding 152/6410 247/18639 0.615384615384615 1.78941557662307 1.87799934826328e-18 3.65673301668979e-16 GO:0061775 cohesin loader activity 105/6410 153/18639 0.686274509803922 1.99554923373406 4.88775039833093e-18 8.32750474115633e-16 GO:0140674 ATP-dependent histone chaperone activity 104/6410 152/18639 0.684210526315789 1.98954758190328 9.86223666764055e-18 1.49358095311045e-15 GO:0016755 aminoacyltransferase activity 262/6410 496/18639 0.528225806451613 1.53597516481304 1.15809553623738e-17 1.57848421589155e-15 GO:0000510 H3-H4 histone complex chaperone activity 103/6410 151/18639 0.682119205298013 1.98346643799527 1.98388145684642e-17 1.93145030405833e-15 GO:0140584 chromatin extrusion motor activity 103/6410 151/18639 0.682119205298013 1.98346643799527 1.98388145684642e-17 1.93145030405833e-15 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 103/6410 151/18639 0.682119205298013 1.98346643799527 1.98388145684642e-17 1.93145030405833e-15 GO:0140849 ATP-dependent H2AZ histone chaperone activity 103/6410 151/18639 0.682119205298013 1.98346643799527 1.98388145684642e-17 1.93145030405833e-15 GO:0031267 small GTPase binding 166/6410 283/18639 0.586572438162544 1.70563551870697 4.02800591602533e-17 3.47650089732495e-15 GO:0015616 DNA translocase activity 103/6410 152/18639 0.677631578947368 1.97041731669267 4.0809988523257e-17 3.47650089732495e-15 GO:0003689 DNA clamp loader activity 107/6410 160/18639 0.66875 1.94459145865835 4.36032337764472e-17 3.49595339042927e-15 GO:0004842 ubiquitin-protein transferase activity 239/6410 449/18639 0.532293986636971 1.54780462042535 9.70884639694266e-17 7.15293987471723e-15 GO:0003714 transcription corepressor activity 128/6410 204/18639 0.627450980392157 1.82450215655685 9.97108273071368e-17 7.15293987471723e-15 GO:0140597 protein carrier chaperone 120/6410 188/18639 0.638297872340426 1.85604275234839 1.34138092786563e-16 9.14151102340427e-15 GO:0140104 molecular carrier activity 149/6410 249/18639 0.598393574297189 1.74000902204763 1.4496721924923e-16 9.40906284936667e-15 GO:0140713 histone chaperone activity 108/6410 164/18639 0.658536585365854 1.91489288839846 1.67799961127446e-16 1.03959703189413e-14 GO:0004386 helicase activity 103/6410 155/18639 0.664516129032258 1.93228020733733 3.27802093667018e-16 1.94258371160063e-14 GO:0051020 GTPase binding 178/6410 315/18639 0.565079365079365 1.64313795408959 4.93901464972877e-16 2.8049487364918e-14 GO:0140297 DNA-binding transcription factor binding 252/6410 488/18639 0.516393442622951 1.50156901358022 1.75192869299565e-15 9.55151523421226e-14 GO:0030695 GTPase regulator activity 252/6410 489/18639 0.515337423312883 1.49849832030091 2.39767532336406e-15 1.25693517913278e-13 GO:0060589 nucleoside-triphosphatase regulator activity 252/6410 490/18639 0.514285714285714 1.49544016046356 3.27429061289448e-15 1.65291040939821e-13 GO:0140030 modification-dependent protein binding 109/6410 173/18639 0.630057803468208 1.83208227751075 1.23199609411934e-14 5.99718098673094e-13 GO:0004674 protein serine/threonine kinase activity 225/6410 433/18639 0.519630484988453 1.51098168638062 2.43970671505605e-14 1.14666215607634e-12 GO:0061659 ubiquitin-like protein ligase activity 198/6410 372/18639 0.532258064516129 1.54770016607116 4.30624082354338e-14 1.95646874749654e-12 GO:0106310 protein serine kinase activity 190/6410 361/18639 0.526315789473684 1.53042121684867 5.55429761169589e-13 2.44209924023919e-11 GO:0016887 ATP hydrolysis activity 212/6410 417/18639 0.508393285371703 1.47830615382889 2.23526787006451e-12 9.17090367560562e-11 GO:0005096 GTPase activator activity 149/6410 271/18639 0.549815498154982 1.59875367708435 2.26310206551305e-12 9.17090367560562e-11 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 183/6410 349/18639 0.524355300859599 1.52472050744494 2.28767956691556e-12 9.17090367560562e-11 GO:0061630 ubiquitin protein ligase activity 184/6410 353/18639 0.521246458923513 1.51568061589319 3.95249153293976e-12 1.53921313125626e-10 GO:0140098 catalytic activity, acting on RNA 194/6410 387/18639 0.501291989664083 1.45765700395458 9.2245318455591e-11 3.49251025152696e-09 GO:0140857 histone H3T45 kinase activity 133/6410 246/18639 0.540650406504065 1.57210342072219 1.57393601879122e-10 5.7980399827363e-09 GO:0035403 histone H3T6 kinase activity 133/6410 247/18639 0.538461538461538 1.56573862954518 2.26151202561248e-10 6.21392174305564e-09 GO:0004676 3-phosphoinositide-dependent protein kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0004711 ribosomal protein S6 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0035175 histone H3S10 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0035979 histone H2AXS139 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0044022 histone H3S28 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0044023 histone H4S1 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0044024 histone H2AS1 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0044025 histone H2BS14 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0072354 histone H3T3 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0072371 histone H2AS121 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0072518 Rho-dependent protein serine/threonine kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0140823 histone H2BS36 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0140855 histone H3S57 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0140995 histone H2A kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0140997 histone H4 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0140998 histone H2B kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:1990244 histone H2AT120 kinase activity 132/6410 245/18639 0.538775510204082 1.56665159667611 2.5074519139256e-10 6.21392174305564e-09 GO:0004679 AMP-activated protein kinase activity 133/6410 248/18639 0.536290322580645 1.55942516732927 3.23429124942046e-10 7.87203388028588e-09 GO:0004677 DNA-dependent protein kinase activity 132/6410 246/18639 0.536585365853659 1.5602830942506 3.5883650556601e-10 8.58059924713108e-09 GO:0035402 histone H3T11 kinase activity 132/6410 247/18639 0.534412955465587 1.55396615864635 5.11136157710607e-10 1.20116997061993e-08 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 130/6410 243/18639 0.534979423868313 1.55561333564454 6.29789145626004e-10 1.45491967031906e-08 GO:0070063 RNA polymerase binding 43/6410 59/18639 0.728813559322034 2.11924429519554 1.74664304381425e-09 3.96779078119804e-08 GO:0044389 ubiquitin-like protein ligase binding 162/6410 322/18639 0.503105590062112 1.46293059175783 2.30777894611601e-09 5.15656180910839e-08 GO:0008186 ATP-dependent activity, acting on RNA 53/6410 79/18639 0.670886075949367 1.9508027409704 2.99845350969413e-09 6.59176150598886e-08 GO:0031625 ubiquitin protein ligase binding 153/6410 302/18639 0.506622516556291 1.47315711171493 3.45184307454108e-09 7.46803509618966e-08 GO:0141003 histone H2AX kinase activity 174/6410 354/18639 0.491525423728814 1.42925778048071 5.60943425995504e-09 1.1946342025498e-07 GO:0140996 histone H3 kinase activity 175/6410 357/18639 0.490196078431373 1.42539230981004 6.54053220904314e-09 1.37149929245012e-07 GO:0035173 histone kinase activity 176/6410 360/18639 0.488888888888889 1.42159126365055 7.60733897738828e-09 1.57103076154246e-07 GO:0003724 RNA helicase activity 51/6410 77/18639 0.662337662337662 1.92594566120307 1.15704530726896e-08 2.35381008030984e-07 GO:0001221 transcription coregulator binding 69/6410 115/18639 0.6 1.74468018720749 1.66509613540062e-08 3.3375382831633e-07 GO:0140034 methylation-dependent protein binding 50/6410 76/18639 0.657894736842105 1.91302652106084 2.25158627733537e-08 4.44769868986682e-07 GO:0032182 ubiquitin-like protein binding 71/6410 120/18639 0.591666666666667 1.72044851794072 2.35307952158231e-08 4.58178198273812e-07 GO:0046332 SMAD binding 51/6410 79/18639 0.645569620253165 1.87718754319793 4.18522449314358e-08 8.03445209035873e-07 GO:0016922 nuclear receptor binding 78/6410 137/18639 0.569343065693431 1.6555359440655 5.11021603013769e-08 9.67392284594122e-07 GO:0043138 3'-5' DNA helicase activity 35/6410 48/18639 0.729166666666667 2.12027106084243 5.6599442383084e-08 1.05678136942662e-06 GO:0035591 signaling adaptor activity 74/6410 129/18639 0.573643410852713 1.66804048906142 7.29865190652267e-08 1.34433277683654e-06 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 41/6410 60/18639 0.683333333333333 1.98699687987519 8.32581663773475e-08 1.49914180181467e-06 GO:0035064 methylated histone binding 48/6410 74/18639 0.648648648648649 1.88614074292701 8.35911789713242e-08 1.49914180181467e-06 GO:1990518 single-stranded 3'-5' DNA helicase activity 34/6410 47/18639 0.723404255319149 2.10351511932818 1.21102488855209e-07 2.14367132869674e-06 GO:0035091 phosphatidylinositol binding 139/6410 284/18639 0.48943661971831 1.42318395552724 2.54966146828835e-07 4.45536997599618e-06 GO:0009378 four-way junction helicase activity 34/6410 48/18639 0.708333333333333 2.05969188767551 2.77752744573229e-07 4.73221238566639e-06 GO:0036121 double-stranded DNA helicase activity 34/6410 48/18639 0.708333333333333 2.05969188767551 2.77752744573229e-07 4.73221238566639e-06 GO:0003678 DNA helicase activity 47/6410 74/18639 0.635135135135135 1.84684614411603 2.91385856215047e-07 4.90319656816184e-06 GO:0061749 forked DNA-dependent helicase activity 33/6410 47/18639 0.702127659574468 2.04164702758323 5.77812784340451e-07 9.60437591531749e-06 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 19/6410 22/18639 0.863636363636364 2.51128208764714 7.22382446466996e-07 1.18627382474038e-05 GO:0043175 RNA polymerase core enzyme binding 30/6410 42/18639 0.714285714285714 2.07700022286606 1.05623956518487e-06 1.71387443731783e-05 GO:0140033 acetylation-dependent protein binding 20/6410 24/18639 0.833333333333333 2.42316692667707 1.14927618388822e-06 1.84289816310546e-05 GO:0008234 cysteine-type peptidase activity 96/6410 187/18639 0.513368983957219 1.49277449172833 1.27185492486122e-06 1.99905818717558e-05 GO:0017116 single-stranded DNA helicase activity 38/6410 58/18639 0.655172413793103 1.90511054924956 1.27599458755888e-06 1.99905818717558e-05 GO:0140463 chromatin-protein adaptor activity 36/6410 54/18639 0.666666666666667 1.93853354134165 1.29482555899789e-06 2.00550822376605e-05 GO:0019902 phosphatase binding 97/6410 190/18639 0.510526315789474 1.48450858034321 1.54834002947626e-06 2.37122186536645e-05 GO:0016757 glycosyltransferase activity 129/6410 267/18639 0.48314606741573 1.40489228557906 1.62145828575549e-06 2.45560849276081e-05 GO:0046915 transition metal ion transmembrane transporter activity 31/6410 45/18639 0.688888888888889 2.00315132605304 2.43719573633301e-06 3.65043713035373e-05 GO:0070577 lysine-acetylated histone binding 19/6410 23/18639 0.826086956521739 2.40209590992335 2.80422588151832e-06 4.1545216049016e-05 GO:0043130 ubiquitin binding 57/6410 100/18639 0.57 1.65744617784711 2.94079727606446e-06 4.3100071906192e-05 GO:0140142 nucleocytoplasmic carrier activity 24/6410 32/18639 0.75 2.18085023400936 3.16876715032945e-06 4.59471236797771e-05 GO:1990841 promoter-specific chromatin binding 42/6410 68/18639 0.617647058823529 1.79599431036065 3.59176225953402e-06 5.1532336418367e-05 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 214/6410 484/18639 0.442148760330579 1.28568030324519 3.63768413476645e-06 5.16475362050696e-05 GO:0001217 DNA-binding transcription repressor activity 132/6410 278/18639 0.474820143884892 1.3806821625383 3.90256132737092e-06 5.48370215382121e-05 GO:0000993 RNA polymerase II complex binding 26/6410 36/18639 0.722222222222222 2.10007800312012 4.01381216045035e-06 5.58247548438146e-05 GO:0003697 single-stranded DNA binding 66/6410 121/18639 0.545454545454545 1.58607289746135 4.09933721766167e-06 5.64383497744733e-05 GO:0001216 DNA-binding transcription activator activity 216/6410 491/18639 0.439918533604888 1.27919524927637 4.99966390097129e-06 6.81454189702387e-05 GO:0008168 methyltransferase activity 101/6410 204/18639 0.495098039215686 1.43964623290814 5.59327842718853e-06 7.54815692698809e-05 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 85/6410 167/18639 0.508982035928144 1.4800181228806 7.77076852591949e-06 0.000103838799027728 GO:0140566 histone reader activity 25/6410 35/18639 0.714285714285714 2.07700022286606 8.51932416890748e-06 0.000112736299439038 GO:0140938 histone H3 methyltransferase activity 31/6410 47/18639 0.659574468085106 1.91791084409334 9.87109756063366e-06 0.000129368326684074 GO:0004843 cysteine-type deubiquitinase activity 59/6410 108/18639 0.546296296296296 1.58852054082163 1.22178096309223e-05 0.000158598805018544 GO:0004197 cysteine-type endopeptidase activity 50/6410 88/18639 0.568181818181818 1.65215926818891 1.32135743789404e-05 0.000169906621495243 GO:0019789 SUMO transferase activity 21/6410 28/18639 0.75 2.18085023400936 1.34050635297302e-05 0.0001707579587946 GO:0045296 cadherin binding 152/6410 334/18639 0.455089820359281 1.32331032163442 1.45713647318681e-05 0.000183896019717928 GO:0016741 transferase activity, transferring one-carbon groups 104/6410 215/18639 0.483720930232558 1.4065638718572 1.48618652018731e-05 0.000185841488717 GO:0019783 ubiquitin-like protein peptidase activity 67/6410 127/18639 0.52755905511811 1.53403638507745 1.5432498758691e-05 0.000191222689164508 GO:0140767 enzyme-substrate adaptor activity 72/6410 139/18639 0.517985611510791 1.50619872276905 1.73425402600195e-05 0.000212953895264924 GO:0002039 p53 binding 41/6410 69/18639 0.594202898550725 1.72782337380452 1.81382732204822e-05 0.000220736307138547 GO:0140693 molecular condensate scaffold activity 31/6410 48/18639 0.645833333333333 1.87795436817473 1.86981715547267e-05 0.000225536352469845 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 125/6410 268/18639 0.466417910447761 1.35625014552821 2.0193146052774e-05 0.000241432088332728 GO:0016758 hexosyltransferase activity 96/6410 197/18639 0.487309644670051 1.41699913681826 2.14095099186384e-05 0.000253749234948732 GO:0000030 mannosyltransferase activity 19/6410 25/18639 0.76 2.20992823712949 2.56118420157908e-05 0.000298367014252333 GO:0008139 nuclear localization sequence binding 19/6410 25/18639 0.76 2.20992823712949 2.56118420157908e-05 0.000298367014252333 GO:0140457 protein demethylase activity 22/6410 31/18639 0.709677419354839 2.06360022142821 3.5336470735375e-05 0.000408166183155221 GO:0010485 histone H4 acetyltransferase activity 24/6410 35/18639 0.685714285714286 1.99392021395142 3.83503983244951e-05 0.000439257083330142 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 108/6410 229/18639 0.471615720524017 1.37136433928973 4.03930982478155e-05 0.000458798274264772 GO:0001098 basal transcription machinery binding 36/6410 60/18639 0.6 1.74468018720749 4.33900556161735e-05 0.000484759391842988 GO:0001099 basal RNA polymerase II transcription machinery binding 36/6410 60/18639 0.6 1.74468018720749 4.33900556161735e-05 0.000484759391842988 GO:0005085 guanyl-nucleotide exchange factor activity 108/6410 230/18639 0.469565217391304 1.36540188564064 5.06135964629667e-05 0.000560864487634338 GO:0101005 deubiquitinase activity 60/6410 115/18639 0.521739130434783 1.51711320626738 6.41604026442784e-05 0.000701691649793729 GO:0052742 phosphatidylinositol kinase activity 19/6410 26/18639 0.730769230769231 2.12493099723989 6.43517653882731e-05 0.000701691649793729 GO:0051787 misfolded protein binding 14/6410 17/18639 0.823529411764706 2.39465908048087 6.86087247729577e-05 0.000742172157663026 GO:0004402 histone acetyltransferase activity 27/6410 42/18639 0.642857142857143 1.86930020057945 7.27559828378888e-05 0.00078083783155939 GO:0032452 histone demethylase activity 21/6410 30/18639 0.7 2.03546021840874 7.38292377820954e-05 0.000786166024195281 GO:0032451 demethylase activity 26/6410 40/18639 0.65 1.89007020280811 7.50020952033473e-05 0.000792463998156297 GO:0019903 protein phosphatase binding 72/6410 144/18639 0.5 1.45390015600624 7.81632834049374e-05 0.000819511963699459 GO:0050660 flavin adenine dinucleotide binding 47/6410 86/18639 0.546511627906977 1.58914668214636 8.95402279164183e-05 0.000931628478244872 GO:0061665 SUMO ligase activity 12/6410 14/18639 0.857142857142857 2.49240026743927 0.00011551664665006 0.00119279688927297 GO:0004518 nuclease activity 98/6410 209/18639 0.4688995215311 1.36346617501064 0.00011744402474838 0.00119661554895897 GO:0061733 protein-lysine-acetyltransferase activity 29/6410 47/18639 0.617021276595745 1.79417466060345 0.000117642321027514 0.00119661554895897 GO:0051539 4 iron, 4 sulfur cluster binding 28/6410 45/18639 0.622222222222222 1.80929797191888 0.000124730219092284 0.00125931324905766 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 17/6410 23/18639 0.739130434782609 2.14924370887879 0.000126182231475894 0.00126460574633561 GO:0016279 protein-lysine N-methyltransferase activity 39/6410 69/18639 0.565217391304348 1.64353930678966 0.000133640336506202 0.00132957502670039 GO:0005543 phospholipid binding 210/6410 497/18639 0.422535211267606 1.2286480191602 0.000134967165078978 0.00133304526088874 GO:0001727 lipid kinase activity 26/6410 41/18639 0.634146341463415 1.84397092956889 0.000138052318243672 0.0013537072645045 GO:0008173 RNA methyltransferase activity 38/6410 67/18639 0.567164179104478 1.6492001769623 0.000147047206151726 0.00142145632613335 GO:0042054 histone methyltransferase activity 38/6410 67/18639 0.567164179104478 1.6492001769623 0.000147047206151726 0.00142145632613335 GO:0016791 phosphatase activity 123/6410 273/18639 0.450549450549451 1.31010783288474 0.00015392429616116 0.00147745644836381 GO:0015923 mannosidase activity 13/6410 16/18639 0.8125 2.36258775351014 0.000165746998287583 0.00157981229836347 GO:0030159 signaling receptor complex adaptor activity 31/6410 52/18639 0.596153846153846 1.73349633985359 0.000171973735183017 0.00162777917398925 GO:0016278 lysine N-methyltransferase activity 39/6410 70/18639 0.557142857142857 1.62006017383552 0.000202232087513062 0.00190098162262278 GO:0000400 four-way junction DNA binding 14/6410 18/18639 0.777777777777778 2.2616224648986 0.000210426065907664 0.00195109338661324 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 14/6410 18/18639 0.777777777777778 2.2616224648986 0.000210426065907664 0.00195109338661324 GO:0030145 manganese ion binding 38/6410 68/18639 0.558823529411765 1.62494723318345 0.000223449495467322 0.00205784906974298 GO:0001223 transcription coactivator binding 27/6410 44/18639 0.613636363636364 1.78433200964402 0.000229339443537805 0.00209791719155724 GO:0004721 phosphoprotein phosphatase activity 83/6410 175/18639 0.474285714285714 1.37912814798306 0.000236083129450436 0.00214520870293963 GO:0019894 kinesin binding 26/6410 42/18639 0.619047619047619 1.80006685981725 0.000244158863278069 0.00218587457955399 GO:0015095 magnesium ion transmembrane transporter activity 15/6410 20/18639 0.75 2.18085023400936 0.000246973356750781 0.00218587457955399 GO:0052745 inositol phosphate phosphatase activity 15/6410 20/18639 0.75 2.18085023400936 0.000246973356750781 0.00218587457955399 GO:0061608 nuclear import signal receptor activity 15/6410 20/18639 0.75 2.18085023400936 0.000246973356750781 0.00218587457955399 GO:0042578 phosphoric ester hydrolase activity 157/6410 363/18639 0.432506887052342 1.25764366111835 0.000250382351112962 0.00220174931978689 GO:0042162 telomeric DNA binding 24/6410 38/18639 0.631578947368421 1.83650546021841 0.000272464364107373 0.00236911971104616 GO:0050321 tau-protein kinase activity 16/6410 22/18639 0.727272727272727 2.1147638632818 0.000274630164596693 0.00236911971104616 GO:0140035 ubiquitin-like protein reader activity 16/6410 22/18639 0.727272727272727 2.1147638632818 0.000274630164596693 0.00236911971104616 GO:0034212 protein N-acetyltransferase activity 31/6410 53/18639 0.584905660377358 1.70078886174315 0.000278485530660819 0.00238726904585344 GO:0016409 palmitoyltransferase activity 23/6410 36/18639 0.638888888888889 1.85776131045242 0.000285081391406126 0.00242853710304094 GO:0004535 poly(A)-specific ribonuclease activity 11/6410 13/18639 0.846153846153846 2.46044641785671 0.000290129056545304 0.00244102409920524 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 11/6410 13/18639 0.846153846153846 2.46044641785671 0.000290129056545304 0.00244102409920524 GO:0008175 tRNA methyltransferase activity 22/6410 34/18639 0.647058823529412 1.88151784894925 0.000295918113934179 0.0024744563760263 GO:0141052 histone H3 demethylase activity 19/6410 28/18639 0.678571428571429 1.97315021172275 0.000309881292713994 0.00257541586566569 GO:0001222 transcription corepressor binding 29/6410 49/18639 0.591836734693878 1.7209430418033 0.000329539875224474 0.00272219909049065 GO:0016874 ligase activity 79/6410 167/18639 0.473053892215569 1.37554625538315 0.000364042098609713 0.0029890926530424 GO:0004559 alpha-mannosidase activity 12/6410 15/18639 0.8 2.32624024960998 0.00039547776258519 0.00319079844600063 GO:0120283 protein serine/threonine kinase binding 12/6410 15/18639 0.8 2.32624024960998 0.00039547776258519 0.00319079844600063 GO:0003684 damaged DNA binding 40/6410 74/18639 0.540540540540541 1.57178395243918 0.00039563091516809 0.00319079844600063 GO:0008276 protein methyltransferase activity 49/6410 95/18639 0.515789473684211 1.4998127925117 0.000411251791452491 0.00329727171617497 GO:1901981 phosphatidylinositol phosphate binding 86/6410 185/18639 0.464864864864865 1.35173419909769 0.000421089470464654 0.0033564032061013 GO:0015631 tubulin binding 164/6410 385/18639 0.425974025974026 1.23864740563649 0.000442743412109658 0.00350848413200851 GO:0015924 mannosyl-oligosaccharide mannosidase activity 9/6410 10/18639 0.9 2.61702028081123 0.000463076642562262 0.00362743370007105 GO:0099122 RNA polymerase II C-terminal domain binding 9/6410 10/18639 0.9 2.61702028081123 0.000463076642562262 0.00362743370007105 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 13/6410 17/18639 0.764705882352941 2.22361200330366 0.000481446387210115 0.00374977957581364 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 60/6410 122/18639 0.491803278688525 1.43006572721925 0.000515988539064282 0.00398200868214141 GO:0004527 exonuclease activity 44/6410 84/18639 0.523809523809524 1.52313349676844 0.000517106043095399 0.00398200868214141 GO:0003756 protein disulfide isomerase activity 14/6410 19/18639 0.736842105263158 2.14258970358814 0.000545605765351219 0.00413144810096507 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 14/6410 19/18639 0.736842105263158 2.14258970358814 0.000545605765351219 0.00413144810096507 GO:0140036 ubiquitin-modified protein reader activity 14/6410 19/18639 0.736842105263158 2.14258970358814 0.000545605765351219 0.00413144810096507 GO:0016407 acetyltransferase activity 49/6410 96/18639 0.510416666666667 1.4841897425897 0.000562080570182488 0.00423268407270017 GO:0032266 phosphatidylinositol-3-phosphate binding 28/6410 48/18639 0.583333333333333 1.69621684867395 0.000577559454174692 0.00432534909912146 GO:0140312 cargo adaptor activity 15/6410 21/18639 0.714285714285714 2.07700022286606 0.00058892743330491 0.0043863830141781 GO:0016417 S-acyltransferase activity 19/6410 29/18639 0.655172413793103 1.90511054924956 0.000609288674451844 0.00451337208303186 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 16/6410 23/18639 0.695652173913043 2.02281760835651 0.000613939726015665 0.0045217790458627 GO:0005385 zinc ion transmembrane transporter activity 18/6410 27/18639 0.666666666666667 1.93853354134165 0.000621223080524828 0.0045217790458627 GO:0017056 structural constituent of nuclear pore 17/6410 25/18639 0.68 1.97730421216849 0.000623693661498303 0.0045217790458627 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 17/6410 25/18639 0.68 1.97730421216849 0.000623693661498303 0.0045217790458627 GO:0030276 clathrin binding 27/6410 46/18639 0.58695652173913 1.7067523570508 0.00063031437710785 0.00454560050792592 GO:0008013 beta-catenin binding 53/6410 106/18639 0.5 1.45390015600624 0.000648870766764745 0.00465479397421235 GO:0003995 acyl-CoA dehydrogenase activity 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 10/6410 12/18639 0.833333333333333 2.42316692667707 0.00072012470815344 0.00500780600618948 GO:0016779 nucleotidyltransferase activity 65/6410 136/18639 0.477941176470588 1.38975750206479 0.000823607462152067 0.00569836025844298 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 33/6410 60/18639 0.55 1.59929017160686 0.000829650890870911 0.00571118264776289 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 23/6410 38/18639 0.605263157894737 1.75998439937597 0.000871655498169908 0.00594033222002793 GO:0042887 amide transmembrane transporter activity 23/6410 38/18639 0.605263157894737 1.75998439937597 0.000871655498169908 0.00594033222002793 GO:0008408 3'-5' exonuclease activity 32/6410 58/18639 0.551724137931034 1.60430362042068 0.000921057125798663 0.00624577543514218 GO:0008174 mRNA methyltransferase activity 11/6410 14/18639 0.785714285714286 2.28470024515266 0.000930374559494531 0.006246800613749 GO:0046030 inositol trisphosphate phosphatase activity 11/6410 14/18639 0.785714285714286 2.28470024515266 0.000930374559494531 0.006246800613749 GO:0042826 histone deacetylase binding 61/6410 127/18639 0.480314960629921 1.39665999238395 0.00100227107715516 0.00666729764085435 GO:0052866 phosphatidylinositol phosphate phosphatase activity 21/6410 34/18639 0.617647058823529 1.79599431036065 0.00100278504502945 0.00666729764085435 GO:0008170 N-methyltransferase activity 49/6410 98/18639 0.5 1.45390015600624 0.00101798134714315 0.00673547852502967 GO:0000287 magnesium ion binding 102/6410 230/18639 0.443478260869565 1.28954622532727 0.00103887293980287 0.00684050153116579 GO:0070717 poly-purine tract binding 20/6410 32/18639 0.625 1.8173751950078 0.00106698533650921 0.00699183179645217 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 12/6410 16/18639 0.75 2.18085023400936 0.00108467005547801 0.00707370950055753 GO:0031624 ubiquitin conjugating enzyme binding 19/6410 30/18639 0.633333333333333 1.84160686427457 0.00112755991242844 0.00721532469784023 GO:0043995 histone H4K5 acetyltransferase activity 19/6410 30/18639 0.633333333333333 1.84160686427457 0.00112755991242844 0.00721532469784023 GO:0043996 histone H4K8 acetyltransferase activity 19/6410 30/18639 0.633333333333333 1.84160686427457 0.00112755991242844 0.00721532469784023 GO:0043997 histone H4K12 acetyltransferase activity 19/6410 30/18639 0.633333333333333 1.84160686427457 0.00112755991242844 0.00721532469784023 GO:0046966 nuclear thyroid hormone receptor binding 18/6410 28/18639 0.642857142857143 1.86930020057945 0.00118163829858433 0.00745001493271434 GO:0051019 mitogen-activated protein kinase binding 18/6410 28/18639 0.642857142857143 1.86930020057945 0.00118163829858433 0.00745001493271434 GO:0035615 clathrin adaptor activity 13/6410 18/18639 0.722222222222222 2.10007800312012 0.00118609922259649 0.00745001493271434 GO:0070064 proline-rich region binding 13/6410 18/18639 0.722222222222222 2.10007800312012 0.00118609922259649 0.00745001493271434 GO:0003727 single-stranded RNA binding 45/6410 89/18639 0.50561797752809 1.4702361128153 0.00119396058066813 0.00746499207087458 GO:0050681 nuclear androgen receptor binding 17/6410 26/18639 0.653846153846154 1.90125405016201 0.00122549789722384 0.00759251651780045 GO:0070412 R-SMAD binding 17/6410 26/18639 0.653846153846154 1.90125405016201 0.00122549789722384 0.00759251651780045 GO:0032934 sterol binding 36/6410 68/18639 0.529411764705882 1.53942369459484 0.0012540920202565 0.00771605656624065 GO:0004407 histone deacetylase activity 15/6410 22/18639 0.681818181818182 1.98259112182669 0.00126242158053681 0.00771605656624065 GO:0033558 protein lysine deacetylase activity 15/6410 22/18639 0.681818181818182 1.98259112182669 0.00126242158053681 0.00771605656624065 GO:0016877 ligase activity, forming carbon-sulfur bonds 24/6410 41/18639 0.585365853658537 1.70212701190974 0.00131634034717856 0.00800969595180528 GO:0043539 protein serine/threonine kinase activator activity 38/6410 73/18639 0.520547945205479 1.51364947748595 0.00140733292430655 0.00852531011479923 GO:0004536 DNA nuclease activity 34/6410 64/18639 0.53125 1.54476891575663 0.00156556033864628 0.00944185283882687 GO:0000175 3'-5'-RNA exonuclease activity 21/6410 35/18639 0.6 1.74468018720749 0.00169897583489184 0.0102013394843946 GO:0008080 N-acetyltransferase activity 36/6410 69/18639 0.521739130434783 1.51711320626738 0.00176268283679752 0.010446916181226 GO:0032404 mismatch repair complex binding 9/6410 11/18639 0.818181818181818 2.37910934619203 0.00176286920152749 0.010446916181226 GO:0047676 arachidonate-CoA ligase activity 9/6410 11/18639 0.818181818181818 2.37910934619203 0.00176286920152749 0.010446916181226 GO:0043021 ribonucleoprotein complex binding 80/6410 177/18639 0.451977401129944 1.31426002802824 0.00179566128253733 0.0105951789095168 GO:0071889 14-3-3 protein binding 20/6410 33/18639 0.606060606060606 1.7623032194015 0.00183743852489439 0.0107486210705195 GO:0140416 transcription regulator inhibitor activity 20/6410 33/18639 0.606060606060606 1.7623032194015 0.00183743852489439 0.0107486210705195 GO:1901505 carbohydrate derivative transmembrane transporter activity 29/6410 53/18639 0.547169811320755 1.5910605480823 0.00187095975751895 0.0108979408098219 GO:0051213 dioxygenase activity 46/6410 93/18639 0.494623655913978 1.43826682099542 0.00189579554984827 0.0109490226035729 GO:0051219 phosphoprotein binding 46/6410 93/18639 0.494623655913978 1.43826682099542 0.00189579554984827 0.0109490226035729 GO:0004520 DNA endonuclease activity 24/6410 42/18639 0.571428571428571 1.66160017829285 0.00207735204826432 0.0119258455629763 GO:0005048 signal sequence binding 28/6410 51/18639 0.549019607843137 1.59643938698724 0.00208242937930181 0.0119258455629763 GO:0010484 histone H3 acetyltransferase activity 18/6410 29/18639 0.620689655172414 1.80484157297326 0.00211821041080111 0.0120800033051126 GO:0005338 nucleotide-sugar transmembrane transporter activity 10/6410 13/18639 0.769230769230769 2.23676947077883 0.00215344354684723 0.0121790188977294 GO:0140852 histone ubiquitin ligase activity 10/6410 13/18639 0.769230769230769 2.23676947077883 0.00215344354684723 0.0121790188977294 GO:0008017 microtubule binding 118/6410 276/18639 0.427536231884058 1.2431899884691 0.00222899325295667 0.0125542058007436 GO:0004532 RNA exonuclease activity 23/6410 40/18639 0.575 1.67198517940718 0.00228919802341218 0.0127876102701263 GO:0071949 FAD binding 23/6410 40/18639 0.575 1.67198517940718 0.00228919802341218 0.0127876102701263 GO:0019209 kinase activator activity 68/6410 148/18639 0.459459459459459 1.3360163595733 0.00230045421302479 0.012798037111644 GO:0019706 protein-cysteine S-palmitoyltransferase activity 16/6410 25/18639 0.64 1.86099219968799 0.0023756461237747 0.013092109774426 GO:0019707 protein-cysteine S-acyltransferase activity 16/6410 25/18639 0.64 1.86099219968799 0.0023756461237747 0.013092109774426 GO:0042809 nuclear vitamin D receptor binding 11/6410 15/18639 0.733333333333333 2.13238689547582 0.00240134075099523 0.013092109774426 GO:0141050 histone H3K deacetylase activity 11/6410 15/18639 0.733333333333333 2.13238689547582 0.00240134075099523 0.013092109774426 GO:0141051 histone H4K deacetylase activity 11/6410 15/18639 0.733333333333333 2.13238689547582 0.00240134075099523 0.013092109774426 GO:0008484 sulfuric ester hydrolase activity 12/6410 17/18639 0.705882352941177 2.05256492612646 0.00253240685932094 0.0136971053541843 GO:0038191 neuropilin binding 12/6410 17/18639 0.705882352941177 2.05256492612646 0.00253240685932094 0.0136971053541843 GO:0140789 histone phosphatase activity 63/6410 136/18639 0.463235294117647 1.34699573277049 0.00256533203954214 0.0138115636557238 GO:1990380 K48-linked deubiquitinase activity 13/6410 19/18639 0.684210526315789 1.98954758190328 0.00257383504662792 0.0138115636557238 GO:0044390 ubiquitin-like protein conjugating enzyme binding 21/6410 36/18639 0.583333333333333 1.69621684867395 0.00276555279839759 0.0147821508400624 GO:0030295 protein kinase activator activity 64/6410 139/18639 0.460431654676259 1.33884330912805 0.0028542410912408 0.0151374731803938 GO:0140101 catalytic activity, acting on a tRNA 64/6410 139/18639 0.460431654676259 1.33884330912805 0.0028542410912408 0.0151374731803938 GO:0031593 polyubiquitin modification-dependent protein binding 31/6410 59/18639 0.525423728813559 1.52782728258283 0.00310198549704983 0.0163876210561199 GO:0019887 protein kinase regulator activity 109/6410 255/18639 0.427450980392157 1.24294209415435 0.00321900794296343 0.0169401846573713 GO:0015605 organophosphate ester transmembrane transporter activity 27/6410 50/18639 0.54 1.57021216848674 0.00340283340332274 0.0178386997258804 GO:0015932 nucleobase-containing compound transmembrane transporter activity 30/6410 57/18639 0.526315789473684 1.53042121684867 0.00347472356349598 0.0181457786093679 GO:0019207 kinase regulator activity 121/6410 287/18639 0.421602787456446 1.22593671691118 0.00351214140068457 0.0182711783554697 GO:0140318 protein transporter activity 23/6410 41/18639 0.560975609756098 1.63120505308017 0.00353229394304406 0.0183061469367645 GO:0016879 ligase activity, forming carbon-nitrogen bonds 26/6410 48/18639 0.541666666666667 1.57505850234009 0.00380118093936308 0.0196250364407268 GO:0036408 histone H3K14 acetyltransferase activity 17/6410 28/18639 0.607142857142857 1.76545018943615 0.00390814284738248 0.0201011271735182 GO:0008143 poly(A) binding 16/6410 26/18639 0.615384615384615 1.78941557662307 0.00421588328625606 0.0215106050805334 GO:0004445 inositol-polyphosphate 5-phosphatase activity 8/6410 10/18639 0.8 2.32624024960998 0.00424530650525568 0.0215106050805334 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 8/6410 10/18639 0.8 2.32624024960998 0.00424530650525568 0.0215106050805334 GO:0045322 unmethylated CpG binding 8/6410 10/18639 0.8 2.32624024960998 0.00424530650525568 0.0215106050805334 GO:0019213 deacetylase activity 21/6410 37/18639 0.567567567567568 1.65037315006114 0.00434116613079474 0.0219148497639749 GO:0035035 histone acetyltransferase binding 15/6410 24/18639 0.625 1.8173751950078 0.00451820590750748 0.0226332682054881 GO:0043998 histone H2A acetyltransferase activity 15/6410 24/18639 0.625 1.8173751950078 0.00451820590750748 0.0226332682054881 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 43/6410 89/18639 0.48314606741573 1.40489228557906 0.00454990131203503 0.0226332682054881 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 43/6410 89/18639 0.48314606741573 1.40489228557906 0.00454990131203503 0.0226332682054881 GO:0001046 core promoter sequence-specific DNA binding 24/6410 44/18639 0.545454545454545 1.58607289746135 0.00474122841585189 0.0234992521120223 GO:0000995 RNA polymerase III general transcription initiation factor activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0005049 nuclear export signal receptor activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0005078 MAP-kinase scaffold activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0005095 GTPase inhibitor activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0016273 arginine N-methyltransferase activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0016274 protein-arginine N-methyltransferase activity 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0035497 cAMP response element binding 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0141221 histone deacetylase activity, hydrolytic mechanism 9/6410 12/18639 0.75 2.18085023400936 0.00489110268164964 0.0235567948943055 GO:0140939 histone H4 methyltransferase activity 13/6410 20/18639 0.65 1.89007020280811 0.00504647279839703 0.0242195155782224 GO:0030983 mismatched DNA binding 10/6410 14/18639 0.714285714285714 2.07700022286606 0.00521111601522898 0.0248347941564933 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 10/6410 14/18639 0.714285714285714 2.07700022286606 0.00521111601522898 0.0248347941564933 GO:0048487 beta-tubulin binding 23/6410 42/18639 0.547619047619048 1.59236683753064 0.00529353939461951 0.0250735978860571 GO:0070411 I-SMAD binding 11/6410 16/18639 0.6875 1.99911271450858 0.00529801628113311 0.0250735978860571 GO:0004519 endonuclease activity 58/6410 127/18639 0.456692913385827 1.3279717960372 0.00541368356535418 0.0255323553618607 GO:0004713 protein tyrosine kinase activity 63/6410 140/18639 0.45 1.30851014040562 0.00581912326007896 0.027332232953266 GO:0140793 histone H2AXY142 phosphatase activity 43/6410 90/18639 0.477777777777778 1.38928237129485 0.00585395289860934 0.027332232953266 GO:0016878 acid-thiol ligase activity 18/6410 31/18639 0.580645161290323 1.68840018116854 0.00585547470458816 0.027332232953266 GO:0015297 antiporter activity 61/6410 135/18639 0.451851851851852 1.31389495579823 0.00589828925378083 0.0274381169041067 GO:0019905 syntaxin binding 31/6410 61/18639 0.508196721311475 1.47773458479323 0.00593950749936939 0.0275358800055798 GO:0017124 SH3 domain binding 53/6410 115/18639 0.460869565217391 1.34011666553619 0.00608709695415505 0.0281244513508926 GO:0004879 nuclear receptor activity 30/6410 59/18639 0.508474576271186 1.47854253153177 0.00667414051174551 0.0307326132348282 GO:0016405 CoA-ligase activity 16/6410 27/18639 0.592592592592593 1.72314092563703 0.00707132794173807 0.0323430200825134 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 16/6410 27/18639 0.592592592592593 1.72314092563703 0.00707132794173807 0.0323430200825134 GO:0000149 SNARE binding 49/6410 106/18639 0.462264150943396 1.34417184234539 0.00758065332266352 0.0345533709172932 GO:0048156 tau protein binding 23/6410 43/18639 0.534883720930233 1.55533505061133 0.00772189314112951 0.0345533709172932 GO:0003707 nuclear steroid receptor activity 15/6410 25/18639 0.6 1.74468018720749 0.00773204558310669 0.0345533709172932 GO:0004709 MAP kinase kinase kinase activity 15/6410 25/18639 0.6 1.74468018720749 0.00773204558310669 0.0345533709172932 GO:0015645 fatty acid ligase activity 15/6410 25/18639 0.6 1.74468018720749 0.00773204558310669 0.0345533709172932 GO:0042974 nuclear retinoic acid receptor binding 15/6410 25/18639 0.6 1.74468018720749 0.00773204558310669 0.0345533709172932 GO:0120515 fatty acid-CoA ligase activity 15/6410 25/18639 0.6 1.74468018720749 0.00773204558310669 0.0345533709172932 GO:0051087 protein-folding chaperone binding 60/6410 134/18639 0.447761194029851 1.30200013970708 0.00794348300834263 0.0353822462103628 GO:0003887 DNA-directed DNA polymerase activity 14/6410 23/18639 0.608695652173913 1.76996540731194 0.00841553923831833 0.037120970814977 GO:0005158 insulin receptor binding 14/6410 23/18639 0.608695652173913 1.76996540731194 0.00841553923831833 0.037120970814977 GO:0044013 histone H2B acetyltransferase activity 14/6410 23/18639 0.608695652173913 1.76996540731194 0.00841553923831833 0.037120970814977 GO:0042169 SH2 domain binding 22/6410 41/18639 0.536585365853659 1.5602830942506 0.00865997755425262 0.0380759658272462 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 30/6410 60/18639 0.5 1.45390015600624 0.00901968901439821 0.0394033209186691 GO:0098531 ligand-modulated transcription factor activity 30/6410 60/18639 0.5 1.45390015600624 0.00901968901439821 0.0394033209186691 GO:0051010 microtubule plus-end binding 13/6410 21/18639 0.619047619047619 1.80006685981725 0.00910423350011598 0.0396455918870865 GO:0160215 deacylase activity 32/6410 65/18639 0.492307692307692 1.43153246129845 0.00948888403526336 0.041189009363261 GO:0000217 DNA secondary structure binding 21/6410 39/18639 0.538461538461538 1.56573862954518 0.00971314945486161 0.0418754502020191 GO:0008574 plus-end-directed microtubule motor activity 12/6410 19/18639 0.631578947368421 1.83650546021841 0.00976991428044173 0.0418754502020191 GO:0042800 histone H3K4 methyltransferase activity 12/6410 19/18639 0.631578947368421 1.83650546021841 0.00976991428044173 0.0418754502020191 GO:0046527 glucosyltransferase activity 12/6410 19/18639 0.631578947368421 1.83650546021841 0.00976991428044173 0.0418754502020191 GO:0008187 poly-pyrimidine tract binding 17/6410 30/18639 0.566666666666667 1.64775351014041 0.0101573268680047 0.043399487526929 GO:0004659 prenyltransferase activity 11/6410 17/18639 0.647058823529412 1.88151784894925 0.0103683002211221 0.0440249009389077 GO:0032183 SUMO binding 11/6410 17/18639 0.647058823529412 1.88151784894925 0.0103683002211221 0.0440249009389077 GO:0004467 long-chain fatty acid-CoA ligase activity 10/6410 15/18639 0.666666666666667 1.93853354134165 0.0108306665436965 0.0446059785741392 GO:0061578 K63-linked deubiquitinase activity 10/6410 15/18639 0.666666666666667 1.93853354134165 0.0108306665436965 0.0446059785741392 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0002162 dystroglycan binding 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0008432 JUN kinase binding 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0045294 alpha-catenin binding 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0180030 inositol phosphate kinase activity 8/6410 11/18639 0.727272727272727 2.1147638632818 0.0108651393151975 0.0446059785741392 GO:0017154 semaphorin receptor activity 9/6410 13/18639 0.692307692307692 2.01309252370095 0.0110508357349551 0.0448282413891183 GO:0035673 oligopeptide transmembrane transporter activity 9/6410 13/18639 0.692307692307692 2.01309252370095 0.0110508357349551 0.0448282413891183 GO:0051011 microtubule minus-end binding 9/6410 13/18639 0.692307692307692 2.01309252370095 0.0110508357349551 0.0448282413891183 GO:0070123 transforming growth factor beta receptor activity, type III 9/6410 13/18639 0.692307692307692 2.01309252370095 0.0110508357349551 0.0448282413891183 GO:0004725 protein tyrosine phosphatase activity 45/6410 98/18639 0.459183673469388 1.33521442898532 0.0117436171516998 0.0474971815364 GO:0050750 low-density lipoprotein particle receptor binding 15/6410 26/18639 0.576923076923077 1.67757710308412 0.0125268123515393 0.0505149267312075 GO:0015485 cholesterol binding 27/6410 54/18639 0.5 1.45390015600624 0.0128584097982827 0.0515470957501746 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 27/6410 54/18639 0.5 1.45390015600624 0.0128584097982827 0.0515470957501746 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 42/6410 91/18639 0.461538461538462 1.3420616824673 0.0131642858648539 0.0526185385155305 GO:0030215 semaphorin receptor binding 14/6410 24/18639 0.583333333333333 1.69621684867395 0.0138718059014535 0.0549871605609968 GO:0070840 dynein complex binding 14/6410 24/18639 0.583333333333333 1.69621684867395 0.0138718059014535 0.0549871605609968 GO:0015036 disulfide oxidoreductase activity 21/6410 40/18639 0.525 1.52659516380655 0.0139182468037739 0.0549871605609968 GO:0030331 nuclear estrogen receptor binding 21/6410 40/18639 0.525 1.52659516380655 0.0139182468037739 0.0549871605609968 GO:0008194 UDP-glycosyltransferase activity 63/6410 145/18639 0.43448275862069 1.26338910108128 0.0143159521153582 0.0563949211943155 GO:1990782 protein tyrosine kinase binding 52/6410 117/18639 0.444444444444444 1.29235569422777 0.015074942467368 0.057839427653189 GO:0008093 cytoskeletal anchor activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0032931 histone H3K56 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0043992 histone H3K9 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0043993 histone H3K18 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0043994 histone H3K23 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0043999 histone H2AK5 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044012 histone H2AK9 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044014 histone H2BK5 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044015 histone H2BK12 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044016 histone H3K4 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044017 histone H3K27 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0044018 histone H3K36 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0046972 histone H4K16 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0140908 histone H3K122 acetyltransferase activity 13/6410 22/18639 0.590909090909091 1.71824563891647 0.0153191734283208 0.057839427653189 GO:0072349 modified amino acid transmembrane transporter activity 17/6410 31/18639 0.548387096774194 1.59460017110362 0.0153810044950104 0.0579124561511028 GO:0043531 ADP binding 20/6410 38/18639 0.526315789473684 1.53042121684867 0.015676318682042 0.0588617695967581 GO:0004712 protein serine/threonine/tyrosine kinase activity 22/6410 43/18639 0.511627906976744 1.48771178754127 0.0172252338418411 0.0640722121119513 GO:0008375 acetylglucosaminyltransferase activity 22/6410 43/18639 0.511627906976744 1.48771178754127 0.0172252338418411 0.0640722121119513 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 16/6410 29/18639 0.551724137931034 1.60430362042068 0.017252018961912 0.0640722121119513 GO:0097472 cyclin-dependent protein kinase activity 16/6410 29/18639 0.551724137931034 1.60430362042068 0.017252018961912 0.0640722121119513 GO:0003725 double-stranded RNA binding 35/6410 75/18639 0.466666666666667 1.35697347893916 0.0184382046915189 0.0681521954271741 GO:0008409 5'-3' exonuclease activity 11/6410 18/18639 0.611111111111111 1.77698907956318 0.0184505943599613 0.0681521954271741 GO:0140296 general transcription initiation factor binding 26/6410 53/18639 0.490566037735849 1.42646807759103 0.0192948904921538 0.0710750048472969 GO:0008266 poly(U) RNA binding 15/6410 27/18639 0.555555555555556 1.61544461778471 0.019346167863791 0.0710750048472969 GO:0042626 ATPase-coupled transmembrane transporter activity 44/6410 98/18639 0.448979591836735 1.30554299723009 0.0197181678500252 0.0722469429558719 GO:0005024 transforming growth factor beta receptor activity 10/6410 16/18639 0.625 1.8173751950078 0.0200517503146354 0.0726875948905534 GO:0005159 insulin-like growth factor receptor binding 10/6410 16/18639 0.625 1.8173751950078 0.0200517503146354 0.0726875948905534 GO:0015562 efflux transmembrane transporter activity 10/6410 16/18639 0.625 1.8173751950078 0.0200517503146354 0.0726875948905534 GO:0034450 ubiquitin-ubiquitin ligase activity 10/6410 16/18639 0.625 1.8173751950078 0.0200517503146354 0.0726875948905534 GO:1901682 sulfur compound transmembrane transporter activity 30/6410 63/18639 0.476190476190476 1.38466681524404 0.0203334874044451 0.0735133775391478 GO:0140223 general transcription initiation factor activity 32/6410 68/18639 0.470588235294118 1.36837661741764 0.0205704375891792 0.07417329744458 GO:0004065 arylsulfatase activity 9/6410 14/18639 0.642857142857143 1.86930020057945 0.0215623312304621 0.0769357525317272 GO:0005545 1-phosphatidylinositol binding 9/6410 14/18639 0.642857142857143 1.86930020057945 0.0215623312304621 0.0769357525317272 GO:0042813 Wnt receptor activity 9/6410 14/18639 0.642857142857143 1.86930020057945 0.0215623312304621 0.0769357525317272 GO:0071933 Arp2/3 complex binding 9/6410 14/18639 0.642857142857143 1.86930020057945 0.0215623312304621 0.0769357525317272 GO:0008378 galactosyltransferase activity 17/6410 32/18639 0.53125 1.54476891575663 0.0224676478334675 0.0783313889491396 GO:0022884 macromolecule transmembrane transporter activity 17/6410 32/18639 0.53125 1.54476891575663 0.0224676478334675 0.0783313889491396 GO:0005025 transforming growth factor beta receptor activity, type I 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0005026 transforming growth factor beta receptor activity, type II 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0016361 activin receptor activity, type I 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0016362 activin receptor activity, type II 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0017002 activin receptor activity 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0035259 nuclear glucocorticoid receptor binding 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:1990247 N6-methyladenosine-containing RNA reader activity 8/6410 12/18639 0.666666666666667 1.93853354134165 0.0228132125822933 0.0783313889491396 GO:0001618 virus receptor activity 37/6410 81/18639 0.45679012345679 1.32825446351187 0.0229191957764032 0.0783313889491396 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0016303 1-phosphatidylinositol-3-kinase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0016427 tRNA (cytidine) methyltransferase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0031957 very long-chain fatty acid-CoA ligase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0043295 glutathione binding 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0051864 histone H3K36 demethylase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0051880 G-quadruplex DNA binding 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0140999 histone H3K4 trimethyltransferase activity 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 7/6410 10/18639 0.7 2.03546021840874 0.0235051636685239 0.0783313889491396 GO:0019208 phosphatase regulator activity 51/6410 117/18639 0.435897435897436 1.267502700108 0.0239037545098062 0.0794654082850388 GO:0140103 catalytic activity, acting on a glycoprotein 13/6410 23/18639 0.565217391304348 1.64353930678966 0.0242938978753239 0.0805658949004052 GO:0016763 pentosyltransferase activity 24/6410 49/18639 0.489795918367347 1.42422872425101 0.0245431895686394 0.0809984682374227 GO:0060590 ATPase regulator activity 24/6410 49/18639 0.489795918367347 1.42422872425101 0.0245431895686394 0.0809984682374227 GO:0019888 protein phosphatase regulator activity 47/6410 107/18639 0.439252336448598 1.27725808097744 0.0252686446208776 0.083191214053759 GO:0140272 exogenous protein binding 37/6410 82/18639 0.451219512195122 1.3120562383471 0.028211375559397 0.0925463086044748 GO:0031072 heat shock protein binding 56/6410 131/18639 0.427480916030534 1.24302914101297 0.0282459753334274 0.0925463086044748 GO:0015179 L-amino acid transmembrane transporter activity 29/6410 62/18639 0.467741935483871 1.36010014594132 0.029129569249294 0.0952124769467331 GO:0004540 RNA nuclease activity 52/6410 121/18639 0.429752066115702 1.24963319193925 0.0302419971514408 0.0986120624818512 GO:0004722 protein serine/threonine phosphatase activity 45/6410 103/18639 0.436893203883495 1.27039819456856 0.0310283621664352 0.100934743753821 GO:0140303 intramembrane lipid transporter activity 22/6410 45/18639 0.488888888888889 1.42159126365055 0.0312990348920256 0.101572820375788 GO:0034237 protein kinase A regulatory subunit binding 14/6410 26/18639 0.538461538461538 1.56573862954518 0.0323718192542189 0.104556373562797 GO:0070006 metalloaminopeptidase activity 14/6410 26/18639 0.538461538461538 1.56573862954518 0.0323718192542189 0.104556373562797 GO:0046965 nuclear retinoid X receptor binding 10/6410 17/18639 0.588235294117647 1.71047077177205 0.0338852504482258 0.108671991437487 GO:0070403 NAD+ binding 10/6410 17/18639 0.588235294117647 1.71047077177205 0.0338852504482258 0.108671991437487 GO:1990226 histone methyltransferase binding 10/6410 17/18639 0.588235294117647 1.71047077177205 0.0338852504482258 0.108671991437487 GO:0030165 PDZ domain binding 37/6410 83/18639 0.44578313253012 1.29624833186099 0.0344053974039978 0.110081118924059 GO:0022804 active transmembrane transporter activity 176/6410 457/18639 0.385120350109409 1.1198530742105 0.0345497803764542 0.110284193566995 GO:0070325 lipoprotein particle receptor binding 16/6410 31/18639 0.516129032258065 1.5008001610387 0.0360047547674548 0.114660001747759 GO:0016798 hydrolase activity, acting on glycosyl bonds 55/6410 130/18639 0.423076923076923 1.23022320892836 0.0362348910382653 0.115123907890806 GO:0050699 WW domain binding 13/6410 24/18639 0.541666666666667 1.57505850234009 0.0366109156626253 0.115768138892108 GO:0140612 DNA damage sensor activity 13/6410 24/18639 0.541666666666667 1.57505850234009 0.0366109156626253 0.115768138892108 GO:0051018 protein kinase A binding 25/6410 53/18639 0.471698113207547 1.3716039207606 0.036692469553478 0.115768138892108 GO:0000774 adenyl-nucleotide exchange factor activity 9/6410 15/18639 0.6 1.74468018720749 0.0376598282606105 0.118272686449797 GO:0015929 hexosaminidase activity 9/6410 15/18639 0.6 1.74468018720749 0.0376598282606105 0.118272686449797 GO:0015101 organic cation transmembrane transporter activity 36/6410 81/18639 0.444444444444444 1.29235569422777 0.0383274594119225 0.119817264170758 GO:0030971 receptor tyrosine kinase binding 36/6410 81/18639 0.444444444444444 1.29235569422777 0.0383274594119225 0.119817264170758 GO:0016410 N-acyltransferase activity 41/6410 94/18639 0.436170212765957 1.2682958807714 0.0392589712314381 0.122448461758467 GO:0002020 protease binding 57/6410 136/18639 0.419117647058824 1.21871042488758 0.0403873903002583 0.125680394929799 GO:0035250 UDP-galactosyltransferase activity 15/6410 29/18639 0.517241379310345 1.50403464414439 0.0408476351562809 0.126534833450025 GO:0043236 laminin binding 15/6410 29/18639 0.517241379310345 1.50403464414439 0.0408476351562809 0.126534833450025 GO:0140517 protein-RNA adaptor activity 12/6410 22/18639 0.545454545454545 1.58607289746135 0.04143396633702 0.127232735825876 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 8/6410 13/18639 0.615384615384615 1.78941557662307 0.0416330155380343 0.127232735825876 GO:0043560 insulin receptor substrate binding 8/6410 13/18639 0.615384615384615 1.78941557662307 0.0416330155380343 0.127232735825876 GO:0046975 histone H3K36 methyltransferase activity 8/6410 13/18639 0.615384615384615 1.78941557662307 0.0416330155380343 0.127232735825876 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 8/6410 13/18639 0.615384615384615 1.78941557662307 0.0416330155380343 0.127232735825876 GO:0097157 pre-mRNA intronic binding 8/6410 13/18639 0.615384615384615 1.78941557662307 0.0416330155380343 0.127232735825876 GO:0003779 actin binding 170/6410 443/18639 0.383747178329571 1.11586016488064 0.0420818324339342 0.128316638942846 GO:0008376 acetylgalactosaminyltransferase activity 17/6410 34/18639 0.5 1.45390015600624 0.0436258600320025 0.132137882719154 GO:0015035 protein-disulfide reductase activity 17/6410 34/18639 0.5 1.45390015600624 0.0436258600320025 0.132137882719154 GO:0030332 cyclin binding 17/6410 34/18639 0.5 1.45390015600624 0.0436258600320025 0.132137882719154 GO:0031491 nucleosome binding 33/6410 74/18639 0.445945945945946 1.29672176076232 0.0437342080403963 0.132172340485721 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:0000099 sulfur amino acid transmembrane transporter activity 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:0032050 clathrin heavy chain binding 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:0034056 estrogen response element binding 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:0140031 phosphorylation-dependent protein binding 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:1900750 oligopeptide binding 7/6410 11/18639 0.636363636363636 1.85041838037158 0.0456252062868451 0.136076928159671 GO:0045309 protein phosphorylated amino acid binding 27/6410 59/18639 0.457627118644068 1.33068827837859 0.0461373495919006 0.137185340430112 GO:0043014 alpha-tubulin binding 21/6410 44/18639 0.477272727272727 1.38781378527868 0.0462675721337435 0.137185340430112 GO:0005496 steroid binding 46/6410 108/18639 0.425925925925926 1.23850754030161 0.0463090423606385 0.137185340430112 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 14/6410 27/18639 0.518518518518518 1.5077483099324 0.0463994438285264 0.137185340430112 GO:0031418 L-ascorbic acid binding 11/6410 20/18639 0.55 1.59929017160686 0.0469249719830464 0.138139820330221 GO:0140664 ATP-dependent DNA damage sensor activity 11/6410 20/18639 0.55 1.59929017160686 0.0469249719830464 0.138139820330221 GO:0005518 collagen binding 32/6410 72/18639 0.444444444444444 1.29235569422777 0.0487986687407106 0.143346089425837 GO:1902936 phosphatidylinositol bisphosphate binding 47/6410 111/18639 0.423423423423423 1.23123076274402 0.0491223194106416 0.1439864975413 GO:0051059 NF-kappaB binding 16/6410 32/18639 0.5 1.45390015600624 0.0495418617014421 0.144904629826321 GO:0000049 tRNA binding 35/6410 80/18639 0.4375 1.27216263650546 0.0514156883712367 0.150063347430397 GO:0035198 miRNA binding 20/6410 42/18639 0.476190476190476 1.38466681524404 0.0523253715681454 0.152067124621284 GO:0051879 Hsp90 protein binding 20/6410 42/18639 0.476190476190476 1.38466681524404 0.0523253715681454 0.152067124621284 GO:0140359 ABC-type transporter activity 22/6410 47/18639 0.468085106382979 1.36109801838882 0.0525905469042997 0.152512586022469 GO:0017025 TBP-class protein binding 13/6410 25/18639 0.52 1.51205616224649 0.0527795241316287 0.152594508781711 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 10/6410 18/18639 0.555555555555556 1.61544461778471 0.0531785705585565 0.152594508781711 GO:0004706 JUN kinase kinase kinase activity 10/6410 18/18639 0.555555555555556 1.61544461778471 0.0531785705585565 0.152594508781711 GO:0015172 acidic amino acid transmembrane transporter activity 10/6410 18/18639 0.555555555555556 1.61544461778471 0.0531785705585565 0.152594508781711 GO:1990381 ubiquitin-specific protease binding 10/6410 18/18639 0.555555555555556 1.61544461778471 0.0531785705585565 0.152594508781711 GO:0031490 chromatin DNA binding 53/6410 128/18639 0.4140625 1.20401106669267 0.0580741842180706 0.166292254389139 GO:0034061 DNA polymerase activity 17/6410 35/18639 0.485714285714286 1.41236015154892 0.0583235817969496 0.166307619224356 GO:0043015 gamma-tubulin binding 17/6410 35/18639 0.485714285714286 1.41236015154892 0.0583235817969496 0.166307619224356 GO:0003688 DNA replication origin binding 9/6410 16/18639 0.5625 1.63563767550702 0.0602987856197213 0.170512956015934 GO:0004707 MAP kinase activity 9/6410 16/18639 0.5625 1.63563767550702 0.0602987856197213 0.170512956015934 GO:0022858 alanine transmembrane transporter activity 9/6410 16/18639 0.5625 1.63563767550702 0.0602987856197213 0.170512956015934 GO:0031435 mitogen-activated protein kinase kinase kinase binding 9/6410 16/18639 0.5625 1.63563767550702 0.0602987856197213 0.170512956015934 GO:0051536 iron-sulfur cluster binding 33/6410 76/18639 0.434210526315789 1.26259750390016 0.0635254227240229 0.179189480687667 GO:0061980 regulatory RNA binding 26/6410 58/18639 0.448275862068966 1.3034966915918 0.0639918973420902 0.179189480687667 GO:0045499 chemorepellent activity 14/6410 28/18639 0.5 1.45390015600624 0.0641558815668242 0.179189480687667 GO:0046875 ephrin receptor binding 14/6410 28/18639 0.5 1.45390015600624 0.0641558815668242 0.179189480687667 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 14/6410 28/18639 0.5 1.45390015600624 0.0641558815668242 0.179189480687667 GO:0097718 disordered domain specific binding 14/6410 28/18639 0.5 1.45390015600624 0.0641558815668242 0.179189480687667 GO:0004860 protein kinase inhibitor activity 36/6410 84/18639 0.428571428571429 1.24620013371963 0.0656067163322559 0.182866982333057 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 22/6410 48/18639 0.458333333333333 1.33274180967239 0.0664118003691367 0.184733232455374 GO:0008474 palmitoyl-(protein) hydrolase activity 8/6410 14/18639 0.571428571428571 1.66160017829285 0.0683939279481307 0.188225511506467 GO:0032454 histone H3K9 demethylase activity 8/6410 14/18639 0.571428571428571 1.66160017829285 0.0683939279481307 0.188225511506467 GO:0098599 palmitoyl hydrolase activity 8/6410 14/18639 0.571428571428571 1.66160017829285 0.0683939279481307 0.188225511506467 GO:0098821 BMP receptor activity 8/6410 14/18639 0.571428571428571 1.66160017829285 0.0683939279481307 0.188225511506467 GO:0005123 death receptor binding 11/6410 21/18639 0.523809523809524 1.52313349676844 0.068633953938895 0.188225511506467 GO:0009931 calcium-dependent protein serine/threonine kinase activity 11/6410 21/18639 0.523809523809524 1.52313349676844 0.068633953938895 0.188225511506467 GO:0035613 RNA stem-loop binding 11/6410 21/18639 0.523809523809524 1.52313349676844 0.068633953938895 0.188225511506467 GO:0015291 secondary active transmembrane transporter activity 111/6410 287/18639 0.386759581881533 1.12461963286894 0.0706432827724425 0.193346976744657 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 35/6410 82/18639 0.426829268292683 1.24113427951752 0.0726409428039591 0.198416042167928 GO:0005160 transforming growth factor beta receptor binding 13/6410 26/18639 0.5 1.45390015600624 0.0731872290090383 0.199110165946745 GO:0097602 cullin family protein binding 13/6410 26/18639 0.5 1.45390015600624 0.0731872290090383 0.199110165946745 GO:0019210 kinase inhibitor activity 38/6410 90/18639 0.422222222222222 1.22773790951638 0.0740852995252203 0.201151918830429 GO:0051540 metal cluster binding 33/6410 77/18639 0.428571428571429 1.24620013371963 0.0755046947259366 0.204598208571474 GO:0000340 RNA 7-methylguanosine cap binding 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0005165 neurotrophin receptor binding 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0005247 voltage-gated chloride channel activity 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0016423 tRNA (guanine) methyltransferase activity 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0017166 vinculin binding 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0036009 protein-glutamine N-methyltransferase activity 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0043047 single-stranded telomeric DNA binding 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0097677 STAT family protein binding 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 7/6410 12/18639 0.583333333333333 1.69621684867395 0.0775619974732177 0.206478520617179 GO:0120227 acyl-CoA binding 10/6410 19/18639 0.526315789473684 1.53042121684867 0.0785030606577297 0.208576358043831 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 24/6410 54/18639 0.444444444444444 1.29235569422777 0.0803946587084216 0.212772659843842 GO:0050661 NADP binding 24/6410 54/18639 0.444444444444444 1.29235569422777 0.0803946587084216 0.212772659843842 GO:0015295 solute:proton symporter activity 12/6410 24/18639 0.5 1.45390015600624 0.0836535300187516 0.220968529875113 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 35/6410 83/18639 0.421686746987952 1.22618085446309 0.085276219987499 0.224819125421588 GO:0090482 vitamin transmembrane transporter activity 16/6410 34/18639 0.470588235294118 1.36837661741764 0.0863926904099881 0.225078319600918 GO:0016504 peptidase activator activity 25/6410 57/18639 0.43859649122807 1.27535101404056 0.0872836618370088 0.225078319600918 GO:0004382 GDP phosphatase activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0005381 iron ion transmembrane transporter activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0005522 profilin binding 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0008239 dipeptidyl-peptidase activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0008641 ubiquitin-like modifier activating enzyme activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0032356 oxidized DNA binding 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0042975 peroxisome proliferator activated receptor binding 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0070097 delta-catenin binding 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0098505 G-rich strand telomeric DNA binding 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0140940 histone H2A methyltransferase activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:1990259 histone H2AQ104 methyltransferase activity 6/6410 10/18639 0.6 1.74468018720749 0.0878515524781281 0.225078319600918 GO:0019199 transmembrane receptor protein kinase activity 33/6410 78/18639 0.423076923076923 1.23022320892836 0.0889604909876367 0.227491837178516 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 9/6410 17/18639 0.529411764705882 1.53942369459484 0.0900140126876536 0.228772442286118 GO:0015278 intracellularly gated calcium channel activity 9/6410 17/18639 0.529411764705882 1.53942369459484 0.0900140126876536 0.228772442286118 GO:0019198 transmembrane receptor protein phosphatase activity 9/6410 17/18639 0.529411764705882 1.53942369459484 0.0900140126876536 0.228772442286118 GO:0005080 protein kinase C binding 23/6410 52/18639 0.442307692307692 1.28614244569783 0.090132649675455 0.228772442286118 GO:0001784 phosphotyrosine residue binding 21/6410 47/18639 0.446808510638298 1.29922992664387 0.0928104161198652 0.235073447913281 GO:0033192 calmodulin-dependent protein phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0140791 histone H2AXS140 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:1990439 MAP kinase serine/threonine phosphatase activity 34/6410 81/18639 0.419753086419753 1.22055815565956 0.0941673533093556 0.235073447913281 GO:0016881 acid-amino acid ligase activity 11/6410 22/18639 0.5 1.45390015600624 0.09583394154077 0.23836069766436 GO:0070034 telomerase RNA binding 11/6410 22/18639 0.5 1.45390015600624 0.09583394154077 0.23836069766436 GO:0004683 calcium/calmodulin-dependent protein kinase activity 13/6410 27/18639 0.481481481481481 1.40005200208008 0.098061600962371 0.242930544850062 GO:0008320 protein transmembrane transporter activity 13/6410 27/18639 0.481481481481481 1.40005200208008 0.098061600962371 0.242930544850062 GO:0120015 sterol transfer activity 15/6410 32/18639 0.46875 1.36303139625585 0.0982059649393867 0.242930544850062 GO:0051117 ATPase binding 35/6410 84/18639 0.416666666666667 1.21158346333853 0.0993258654555293 0.245255714883852 GO:0140299 molecular sensor activity 30/6410 71/18639 0.422535211267606 1.2286480191602 0.102791788856092 0.253354806891235 GO:0005041 low-density lipoprotein particle receptor activity 8/6410 15/18639 0.533333333333333 1.55082683307332 0.103518613305297 0.25422679267589 GO:0140776 protein-containing complex destabilizing activity 8/6410 15/18639 0.533333333333333 1.55082683307332 0.103518613305297 0.25422679267589 GO:0004177 aminopeptidase activity 18/6410 40/18639 0.45 1.30851014040562 0.107452135419042 0.263412339165746 GO:0033549 MAP kinase phosphatase activity 34/6410 82/18639 0.414634146341463 1.20567330010274 0.109415227417345 0.267743186660397 GO:0000339 RNA cap binding 10/6410 20/18639 0.5 1.45390015600624 0.110081149332413 0.268889975878277 GO:0015662 P-type ion transporter activity 12/6410 25/18639 0.48 1.39574414976599 0.112152612376096 0.272971447622533 GO:0140358 P-type transmembrane transporter activity 12/6410 25/18639 0.48 1.39574414976599 0.112152612376096 0.272971447622533 GO:0002161 aminoacyl-tRNA editing activity 7/6410 13/18639 0.538461538461538 1.56573862954518 0.119479143064265 0.288741262405306 GO:0008417 fucosyltransferase activity 7/6410 13/18639 0.538461538461538 1.56573862954518 0.119479143064265 0.288741262405306 GO:0046974 histone H3K9 methyltransferase activity 7/6410 13/18639 0.538461538461538 1.56573862954518 0.119479143064265 0.288741262405306 GO:0140666 annealing activity 7/6410 13/18639 0.538461538461538 1.56573862954518 0.119479143064265 0.288741262405306 GO:0030544 Hsp70 protein binding 22/6410 51/18639 0.431372549019608 1.25434523263283 0.122030727474525 0.294385631058014 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 28/6410 67/18639 0.417910447761194 1.21520013039328 0.126025557968688 0.303485575108341 GO:0008308 voltage-gated monoatomic anion channel activity 9/6410 18/18639 0.5 1.45390015600624 0.126849454816751 0.30439402625921 GO:0030228 lipoprotein particle receptor activity 9/6410 18/18639 0.5 1.45390015600624 0.126849454816751 0.30439402625921 GO:0030291 protein serine/threonine kinase inhibitor activity 20/6410 46/18639 0.434782608695652 1.26426100522282 0.127128880291904 0.304528407447917 GO:0008171 O-methyltransferase activity 11/6410 23/18639 0.478260869565217 1.3906871057451 0.128560517015845 0.306342630581462 GO:0042171 lysophosphatidic acid acyltransferase activity 11/6410 23/18639 0.478260869565217 1.3906871057451 0.128560517015845 0.306342630581462 GO:0071617 lysophospholipid acyltransferase activity 11/6410 23/18639 0.478260869565217 1.3906871057451 0.128560517015845 0.306342630581462 GO:0008238 exopeptidase activity 41/6410 102/18639 0.401960784313726 1.16882169404423 0.129076786864579 0.307036056712777 GO:0003925 G protein activity 23/6410 54/18639 0.425925925925926 1.23850754030161 0.130458089551347 0.309781142959034 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 18/6410 41/18639 0.439024390243902 1.27659525893231 0.132223248762871 0.31342658793703 GO:0005225 volume-sensitive anion channel activity 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0019107 myristoyltransferase activity 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0019215 intermediate filament binding 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0032794 GTPase activating protein binding 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0048185 activin binding 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0097493 structural molecule activity conferring elasticity 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0140537 transcription regulator activator activity 6/6410 11/18639 0.545454545454545 1.58607289746135 0.138523167907668 0.322747141637865 GO:0120013 lipid transfer activity 27/6410 65/18639 0.415384615384615 1.20785551422057 0.139447766518761 0.324346938165649 GO:0043178 alcohol binding 37/6410 92/18639 0.402173913043478 1.16944142983111 0.142692034832687 0.331327501664315 GO:0017018 myosin phosphatase activity 34/6410 84/18639 0.404761904761905 1.17696679295743 0.144415179355314 0.334455677375516 GO:0008157 protein phosphatase 1 binding 12/6410 26/18639 0.461538461538462 1.3420616824673 0.145551512405003 0.334455677375516 GO:0043548 phosphatidylinositol 3-kinase binding 12/6410 26/18639 0.461538461538462 1.3420616824673 0.145551512405003 0.334455677375516 GO:0015399 primary active transmembrane transporter activity 64/6410 166/18639 0.385542168674699 1.12107963836626 0.146466105419959 0.334455677375516 GO:0000062 fatty-acyl-CoA binding 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0004708 MAP kinase kinase activity 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0005324 long-chain fatty acid transmembrane transporter activity 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0005521 lamin binding 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0097027 ubiquitin-protein transferase activator activity 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0140328 floppase activity 8/6410 16/18639 0.5 1.45390015600624 0.146738440990872 0.334455677375516 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 10/6410 21/18639 0.476190476190476 1.38466681524404 0.147760417871975 0.335103909416808 GO:0010314 phosphatidylinositol-5-phosphate binding 10/6410 21/18639 0.476190476190476 1.38466681524404 0.147760417871975 0.335103909416808 GO:0072542 protein phosphatase activator activity 10/6410 21/18639 0.476190476190476 1.38466681524404 0.147760417871975 0.335103909416808 GO:0043495 protein-membrane adaptor activity 20/6410 47/18639 0.425531914893617 1.23736183489893 0.152549964863785 0.34539136563013 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 50/6410 128/18639 0.390625 1.13585949687988 0.153143452598949 0.346160076106746 GO:0008374 O-acyltransferase activity 23/6410 55/18639 0.418181818181818 1.21598922138704 0.154075078683553 0.347689291797488 GO:0043022 ribosome binding 44/6410 112/18639 0.392857142857143 1.14235012257633 0.159992653165634 0.360446258288859 GO:0051861 glycolipid binding 13/6410 29/18639 0.448275862068966 1.3034966915918 0.161194811993762 0.361958037475283 GO:0106222 lncRNA binding 13/6410 29/18639 0.448275862068966 1.3034966915918 0.161194811993762 0.361958037475283 GO:0035401 histone H3Y41 kinase activity 45/6410 115/18639 0.391304347826087 1.13783490470054 0.164628521907642 0.368454310936152 GO:0140801 histone H2AXY142 kinase activity 45/6410 115/18639 0.391304347826087 1.13783490470054 0.164628521907642 0.368454310936152 GO:0001091 RNA polymerase II general transcription initiation factor binding 11/6410 24/18639 0.458333333333333 1.33274180967239 0.166558736782616 0.369738694193331 GO:0042625 ATPase-coupled ion transmembrane transporter activity 11/6410 24/18639 0.458333333333333 1.33274180967239 0.166558736782616 0.369738694193331 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 11/6410 24/18639 0.458333333333333 1.33274180967239 0.166558736782616 0.369738694193331 GO:0046961 proton-transporting ATPase activity, rotational mechanism 11/6410 24/18639 0.458333333333333 1.33274180967239 0.166558736782616 0.369738694193331 GO:0050431 transforming growth factor beta binding 11/6410 24/18639 0.458333333333333 1.33274180967239 0.166558736782616 0.369738694193331 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 9/6410 19/18639 0.473684210526316 1.37737909516381 0.17036120955987 0.373160867094517 GO:0005346 purine ribonucleotide transmembrane transporter activity 9/6410 19/18639 0.473684210526316 1.37737909516381 0.17036120955987 0.373160867094517 GO:0004705 JUN kinase activity 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0005161 platelet-derived growth factor receptor binding 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0005313 L-glutamate transmembrane transporter activity 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0008559 ABC-type xenobiotic transporter activity 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0042043 neurexin family protein binding 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0098847 sequence-specific single stranded DNA binding 7/6410 14/18639 0.5 1.45390015600624 0.170564358180399 0.373160867094517 GO:0016251 RNA polymerase II general transcription initiation factor activity 22/6410 53/18639 0.415094339622642 1.20701145026933 0.171175336521087 0.373897409740771 GO:0042910 xenobiotic transmembrane transporter activity 14/6410 32/18639 0.4375 1.27216263650546 0.175635351631823 0.383025574838679 GO:0061791 GTPase motor activity 17/6410 40/18639 0.425 1.2358151326053 0.179518135275426 0.390244367432865 GO:1990606 membrane scission GTPase motor activity 17/6410 40/18639 0.425 1.2358151326053 0.179518135275426 0.390244367432865 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 34/6410 86/18639 0.395348837209302 1.14959547219098 0.185313801406925 0.402201769614075 GO:0034062 5'-3' RNA polymerase activity 10/6410 22/18639 0.454545454545455 1.32172741455113 0.191032481481311 0.413297257554012 GO:0097747 RNA polymerase activity 10/6410 22/18639 0.454545454545455 1.32172741455113 0.191032481481311 0.413297257554012 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 8/6410 17/18639 0.470588235294118 1.36837661741764 0.197160155038177 0.420893425944746 GO:0017110 nucleoside diphosphate phosphatase activity 8/6410 17/18639 0.470588235294118 1.36837661741764 0.197160155038177 0.420893425944746 GO:0070402 NADPH binding 8/6410 17/18639 0.470588235294118 1.36837661741764 0.197160155038177 0.420893425944746 GO:1901567 fatty acid derivative binding 8/6410 17/18639 0.470588235294118 1.36837661741764 0.197160155038177 0.420893425944746 GO:0035925 mRNA 3'-UTR AU-rich region binding 13/6410 30/18639 0.433333333333333 1.26004680187207 0.198976066333794 0.420893425944746 GO:0051721 protein phosphatase 2A binding 13/6410 30/18639 0.433333333333333 1.26004680187207 0.198976066333794 0.420893425944746 GO:0004300 enoyl-CoA hydratase activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0031543 peptidyl-proline dioxygenase activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0034452 dynactin binding 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0035014 phosphatidylinositol 3-kinase regulator activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0035251 UDP-glucosyltransferase activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0045295 gamma-catenin binding 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0070008 serine-type exopeptidase activity 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0070410 co-SMAD binding 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:1990459 transferrin receptor binding 6/6410 12/18639 0.5 1.45390015600624 0.199484338342118 0.420893425944746 GO:0008081 phosphoric diester hydrolase activity 34/6410 87/18639 0.390804597701149 1.13638173113131 0.207858050912941 0.43788334373159 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 11/6410 25/18639 0.44 1.27943213728549 0.209306405959167 0.439575703116093 GO:0019211 phosphatase activator activity 11/6410 25/18639 0.44 1.27943213728549 0.209306405959167 0.439575703116093 GO:0015175 neutral L-amino acid transmembrane transporter activity 17/6410 41/18639 0.414634146341463 1.20567330010274 0.213018679888487 0.446119770603159 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 14/6410 33/18639 0.424242424242424 1.23361225358105 0.213077014426014 0.446119770603159 GO:0005516 calmodulin binding 77/6410 207/18639 0.371980676328502 1.08164552669063 0.216380953145819 0.452342391315569 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 9/6410 20/18639 0.45 1.30851014040562 0.219681258836881 0.457837241276251 GO:0030742 GTP-dependent protein binding 9/6410 20/18639 0.45 1.30851014040562 0.219681258836881 0.457837241276251 GO:0016790 thiolester hydrolase activity 18/6410 44/18639 0.409090909090909 1.18955467309601 0.223853998528512 0.465821374037194 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 7/6410 15/18639 0.466666666666667 1.35697347893916 0.229229384946114 0.473396101056946 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 7/6410 15/18639 0.466666666666667 1.35697347893916 0.229229384946114 0.473396101056946 GO:0047372 monoacylglycerol lipase activity 7/6410 15/18639 0.466666666666667 1.35697347893916 0.229229384946114 0.473396101056946 GO:0048531 beta-1,3-galactosyltransferase activity 7/6410 15/18639 0.466666666666667 1.35697347893916 0.229229384946114 0.473396101056946 GO:0098632 cell-cell adhesion mediator activity 22/6410 55/18639 0.4 1.16312012480499 0.22923068723227 0.473396101056946 GO:0016853 isomerase activity 67/6410 180/18639 0.372222222222222 1.08234789391576 0.233116812486861 0.474991164980376 GO:0000182 rDNA binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0008140 cAMP response element binding protein binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0008190 eukaryotic initiation factor 4E binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0015643 toxic substance binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0015658 branched-chain amino acid transmembrane transporter activity 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0030957 Tat protein binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0031434 mitogen-activated protein kinase kinase binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0043422 protein kinase B binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0070739 protein-glutamic acid ligase activity 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0070740 tubulin-glutamic acid ligase activity 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:1905394 retromer complex binding 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:1990757 ubiquitin ligase activator activity 5/6410 10/18639 0.5 1.45390015600624 0.23523040085235 0.474991164980376 GO:0016411 acylglycerol O-acyltransferase activity 13/6410 31/18639 0.419354838709677 1.21940013084394 0.240298784552619 0.483792087659113 GO:0070273 phosphatidylinositol-4-phosphate binding 13/6410 31/18639 0.419354838709677 1.21940013084394 0.240298784552619 0.483792087659113 GO:0005178 integrin binding 60/6410 161/18639 0.372670807453416 1.08365229019099 0.244212405667102 0.490946178354366 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 24/6410 61/18639 0.39344262295082 1.1440525817754 0.245729199212567 0.493267891791942 GO:0019838 growth factor binding 51/6410 136/18639 0.375 1.09042511700468 0.248080613661614 0.497255700618793 GO:0003774 cytoskeletal motor activity 57/6410 153/18639 0.372549019607843 1.08329815545563 0.251966592930366 0.502759940085119 GO:0016860 intramolecular oxidoreductase activity 21/6410 53/18639 0.39622641509434 1.15214729343891 0.252609033832634 0.502759940085119 GO:0000900 mRNA regulatory element binding translation repressor activity 8/6410 18/18639 0.444444444444444 1.29235569422777 0.253408715215317 0.502759940085119 GO:0016854 racemase and epimerase activity 8/6410 18/18639 0.444444444444444 1.29235569422777 0.253408715215317 0.502759940085119 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 8/6410 18/18639 0.444444444444444 1.29235569422777 0.253408715215317 0.502759940085119 GO:0017075 syntaxin-1 binding 8/6410 18/18639 0.444444444444444 1.29235569422777 0.253408715215317 0.502759940085119 GO:0017128 phospholipid scramblase activity 8/6410 18/18639 0.444444444444444 1.29235569422777 0.253408715215317 0.502759940085119 GO:0004529 DNA exonuclease activity 11/6410 26/18639 0.423076923076923 1.23022320892836 0.256059994565554 0.507281646210537 GO:0004715 non-membrane spanning protein tyrosine kinase activity 18/6410 45/18639 0.4 1.16312012480499 0.259398018817217 0.513148765816933 GO:0050840 extracellular matrix binding 26/6410 67/18639 0.388059701492537 1.12840012107947 0.260749015100544 0.515073779104408 GO:0097110 scaffold protein binding 27/6410 70/18639 0.385714285714286 1.12158012034767 0.267775557964436 0.52646409203467 GO:0009982 pseudouridine synthase activity 6/6410 13/18639 0.461538461538462 1.3420616824673 0.268060220008849 0.52646409203467 GO:0031994 insulin-like growth factor I binding 6/6410 13/18639 0.461538461538462 1.3420616824673 0.268060220008849 0.52646409203467 GO:0070700 BMP receptor binding 6/6410 13/18639 0.461538461538462 1.3420616824673 0.268060220008849 0.52646409203467 GO:0004521 RNA endonuclease activity 28/6410 73/18639 0.383561643835616 1.11532066762123 0.274512040263225 0.538359583998239 GO:0030515 snoRNA binding 13/6410 32/18639 0.40625 1.18129387675507 0.284542186024742 0.556428980705485 GO:0043425 bHLH transcription factor binding 13/6410 32/18639 0.40625 1.18129387675507 0.284542186024742 0.556428980705485 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 17/6410 43/18639 0.395348837209302 1.14959547219098 0.287294866190049 0.561007023806642 GO:0030552 cAMP binding 10/6410 24/18639 0.416666666666667 1.21158346333853 0.2908943401766 0.566266872445651 GO:0070300 phosphatidic acid binding 10/6410 24/18639 0.416666666666667 1.21158346333853 0.2908943401766 0.566266872445651 GO:0005548 phospholipid transporter activity 26/6410 68/18639 0.382352941176471 1.11180600165183 0.291234833150698 0.566266872445651 GO:0008296 3'-5'-DNA exonuclease activity 7/6410 16/18639 0.4375 1.27216263650546 0.293389008022413 0.568024457293394 GO:0016722 oxidoreductase activity, acting on metal ions 7/6410 16/18639 0.4375 1.27216263650546 0.293389008022413 0.568024457293394 GO:0140327 flippase activity 7/6410 16/18639 0.4375 1.27216263650546 0.293389008022413 0.568024457293394 GO:0051015 actin filament binding 76/6410 209/18639 0.363636363636364 1.0573819316409 0.295986804357854 0.57224115509185 GO:0005154 epidermal growth factor receptor binding 14/6410 35/18639 0.4 1.16312012480499 0.296692350884164 0.572792739738125 GO:0004714 transmembrane receptor protein tyrosine kinase activity 23/6410 60/18639 0.383333333333333 1.11465678627145 0.302260340176889 0.582716893438613 GO:0001671 ATPase activator activity 11/6410 27/18639 0.407407407407407 1.18465938637545 0.305915124757485 0.588929823509113 GO:0005109 frizzled binding 15/6410 38/18639 0.394736842105263 1.14781591263651 0.307753030260721 0.591632412193742 GO:0005520 insulin-like growth factor binding 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0008381 mechanosensitive monoatomic ion channel activity 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0015245 fatty acid transmembrane transporter activity 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0031420 alkali metal ion binding 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0042577 lipid phosphatase activity 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0046624 sphingolipid transporter activity 8/6410 19/18639 0.421052631578947 1.22433697347894 0.313806901146552 0.59538358937034 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0004143 ATP-dependent diacylglycerol kinase activity 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0015173 aromatic amino acid transmembrane transporter activity 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0034511 U3 snoRNA binding 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0035252 UDP-xylosyltransferase activity 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0042285 xylosyltransferase activity 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0099528 G protein-coupled neurotransmitter receptor activity 5/6410 11/18639 0.454545454545455 1.32172741455113 0.315819761639586 0.59538358937034 GO:0001965 G-protein alpha-subunit binding 12/6410 30/18639 0.4 1.16312012480499 0.319165885548254 0.599205374658773 GO:0015215 nucleotide transmembrane transporter activity 12/6410 30/18639 0.4 1.16312012480499 0.319165885548254 0.599205374658773 GO:0016769 transferase activity, transferring nitrogenous groups 12/6410 30/18639 0.4 1.16312012480499 0.319165885548254 0.599205374658773 GO:0140311 protein sequestering activity 13/6410 33/18639 0.393939393939394 1.14549709261098 0.330994547563916 0.620557865652844 GO:0015926 glucosidase activity 6/6410 14/18639 0.428571428571429 1.24620013371963 0.341182116380186 0.636157626027625 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6/6410 14/18639 0.428571428571429 1.24620013371963 0.341182116380186 0.636157626027625 GO:0019992 diacylglycerol binding 6/6410 14/18639 0.428571428571429 1.24620013371963 0.341182116380186 0.636157626027625 GO:0034236 protein kinase A catalytic subunit binding 6/6410 14/18639 0.428571428571429 1.24620013371963 0.341182116380186 0.636157626027625 GO:0055106 ubiquitin-protein transferase regulator activity 14/6410 36/18639 0.388888888888889 1.1308112324493 0.341659495823183 0.636177449189888 GO:0008483 transaminase activity 10/6410 25/18639 0.4 1.16312012480499 0.345286296321556 0.640306424335075 GO:0047617 fatty acyl-CoA hydrolase activity 10/6410 25/18639 0.4 1.16312012480499 0.345286296321556 0.640306424335075 GO:0120020 cholesterol transfer activity 10/6410 25/18639 0.4 1.16312012480499 0.345286296321556 0.640306424335075 GO:0051082 unfolded protein binding 44/6410 121/18639 0.363636363636364 1.0573819316409 0.35537955614981 0.658128172598085 GO:0050698 proteoglycan sulfotransferase activity 11/6410 28/18639 0.392857142857143 1.14235012257633 0.357873314400851 0.661847120119891 GO:0005092 GDP-dissociation inhibitor activity 7/6410 17/18639 0.411764705882353 1.19732954024043 0.360749205111379 0.665360171267671 GO:0032977 membrane insertase activity 7/6410 17/18639 0.411764705882353 1.19732954024043 0.360749205111379 0.665360171267671 GO:0098631 cell adhesion mediator activity 28/6410 76/18639 0.368421052631579 1.07129485179407 0.366640960981457 0.675313013267198 GO:0005452 solute:inorganic anion antiporter activity 12/6410 31/18639 0.387096774193548 1.12560012077902 0.368976686177076 0.676871094561715 GO:0008327 methyl-CpG binding 12/6410 31/18639 0.387096774193548 1.12560012077902 0.368976686177076 0.676871094561715 GO:0017147 Wnt-protein binding 12/6410 31/18639 0.387096774193548 1.12560012077902 0.368976686177076 0.676871094561715 GO:0003924 GTPase activity 117/6410 331/18639 0.353474320241692 1.02783273868719 0.375715280269226 0.687078500546369 GO:0016004 phospholipase activator activity 8/6410 20/18639 0.4 1.16312012480499 0.376557329352999 0.687078500546369 GO:0016505 peptidase activator activity involved in apoptotic process 8/6410 20/18639 0.4 1.16312012480499 0.376557329352999 0.687078500546369 GO:0043024 ribosomal small subunit binding 8/6410 20/18639 0.4 1.16312012480499 0.376557329352999 0.687078500546369 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 13/6410 34/18639 0.382352941176471 1.11180600165183 0.378893886504883 0.690417603350476 GO:0016597 amino acid binding 19/6410 51/18639 0.372549019607843 1.08329815545563 0.383089246641583 0.696498699504586 GO:0003777 microtubule motor activity 25/6410 68/18639 0.367647058823529 1.06904423235753 0.383253136191078 0.696498699504586 GO:0051287 NAD binding 20/6410 54/18639 0.37037037037037 1.07696307852314 0.389704654863748 0.705210311809116 GO:0000295 adenine nucleotide transmembrane transporter activity 9/6410 23/18639 0.391304347826087 1.13783490470054 0.389756457779156 0.705210311809116 GO:0017134 fibroblast growth factor binding 9/6410 23/18639 0.391304347826087 1.13783490470054 0.389756457779156 0.705210311809116 GO:0005525 GTP binding 133/6410 378/18639 0.351851851851852 1.02311492459698 0.390116342702915 0.705210311809116 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 5/6410 12/18639 0.416666666666667 1.21158346333853 0.398916492566349 0.717312901540809 GO:0015368 calcium:monoatomic cation antiporter activity 5/6410 12/18639 0.416666666666667 1.21158346333853 0.398916492566349 0.717312901540809 GO:0035197 siRNA binding 5/6410 12/18639 0.416666666666667 1.21158346333853 0.398916492566349 0.717312901540809 GO:0097371 MDM2/MDM4 family protein binding 5/6410 12/18639 0.416666666666667 1.21158346333853 0.398916492566349 0.717312901540809 GO:0015216 purine nucleotide transmembrane transporter activity 10/6410 26/18639 0.384615384615385 1.11838473538942 0.401052734919057 0.719256418019308 GO:0016289 acyl-CoA hydrolase activity 10/6410 26/18639 0.384615384615385 1.11838473538942 0.401052734919057 0.719256418019308 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/6410 29/18639 0.379310344827586 1.10295873903922 0.410907587840973 0.735961947736197 GO:0008242 omega peptidase activity 6/6410 15/18639 0.4 1.16312012480499 0.415817270669567 0.741831073197147 GO:0010181 FMN binding 6/6410 15/18639 0.4 1.16312012480499 0.415817270669567 0.741831073197147 GO:0015556 C4-dicarboxylate transmembrane transporter activity 6/6410 15/18639 0.4 1.16312012480499 0.415817270669567 0.741831073197147 GO:0031369 translation initiation factor binding 12/6410 32/18639 0.375 1.09042511700468 0.419637386268476 0.747667656841742 GO:0019003 GDP binding 27/6410 75/18639 0.36 1.04680811232449 0.426867448537998 0.758501172778354 GO:0044183 protein folding chaperone 27/6410 75/18639 0.36 1.04680811232449 0.426867448537998 0.758501172778354 GO:0140313 molecular sequestering activity 20/6410 55/18639 0.363636363636364 1.0573819316409 0.428358187397454 0.758501172778354 GO:0008525 phosphatidylcholine transporter activity 7/6410 18/18639 0.388888888888889 1.1308112324493 0.42905678959069 0.758501172778354 GO:0034185 apolipoprotein binding 7/6410 18/18639 0.388888888888889 1.1308112324493 0.42905678959069 0.758501172778354 GO:0050811 GABA receptor binding 7/6410 18/18639 0.388888888888889 1.1308112324493 0.42905678959069 0.758501172778354 GO:0000146 microfilament motor activity 14/6410 38/18639 0.368421052631579 1.07129485179407 0.434563673732251 0.767241304788936 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 8/6410 21/18639 0.380952380952381 1.10773345219523 0.439902215379115 0.774659844395005 GO:1904047 S-adenosyl-L-methionine binding 8/6410 21/18639 0.380952380952381 1.10773345219523 0.439902215379115 0.774659844395005 GO:0004622 lysophospholipase activity 9/6410 24/18639 0.375 1.09042511700468 0.44907372834069 0.78775738961179 GO:0005315 phosphate transmembrane transporter activity 9/6410 24/18639 0.375 1.09042511700468 0.44907372834069 0.78775738961179 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 9/6410 24/18639 0.375 1.09042511700468 0.44907372834069 0.78775738961179 GO:0032813 tumor necrosis factor receptor superfamily binding 18/6410 50/18639 0.36 1.04680811232449 0.457724876109958 0.801901036166931 GO:0070566 adenylyltransferase activity 11/6410 30/18639 0.366666666666667 1.06619344773791 0.46402120495781 0.806107537605069 GO:0001094 TFIID-class transcription factor complex binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0004090 carbonyl reductase (NADPH) activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0004862 cAMP-dependent protein kinase inhibitor activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0005131 growth hormone receptor binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0005337 nucleoside transmembrane transporter activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0005345 purine nucleobase transmembrane transporter activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0016783 sulfurtransferase activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0019911 structural constituent of myelin sheath 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0031956 medium-chain fatty acid-CoA ligase activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0050815 phosphoserine residue binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0070513 death domain binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0097177 mitochondrial ribosome binding 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0140135 mechanosensitive monoatomic cation channel activity 4/6410 10/18639 0.4 1.16312012480499 0.469588690284978 0.806107537605069 GO:0072341 modified amino acid binding 32/6410 91/18639 0.351648351648352 1.02252318664175 0.477387305607221 0.81831071522185 GO:0005319 lipid transporter activity 62/6410 178/18639 0.348314606741573 1.01282932216165 0.478739981579417 0.81831071522185 GO:0038024 cargo receptor activity 23/6410 65/18639 0.353846153846154 1.02891395655826 0.479336358737172 0.81831071522185 GO:0045159 myosin II binding 5/6410 13/18639 0.384615384615385 1.11838473538942 0.480701662914786 0.81831071522185 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 5/6410 13/18639 0.384615384615385 1.11838473538942 0.480701662914786 0.81831071522185 GO:0061459 L-arginine transmembrane transporter activity 5/6410 13/18639 0.384615384615385 1.11838473538942 0.480701662914786 0.81831071522185 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 63/6410 181/18639 0.348066298342541 1.01210729092147 0.480900134183934 0.81831071522185 GO:0008142 oxysterol binding 6/6410 16/18639 0.375 1.09042511700468 0.48927422825786 0.829453697904805 GO:0017070 U6 snRNA binding 6/6410 16/18639 0.375 1.09042511700468 0.48927422825786 0.829453697904805 GO:0030275 LRR domain binding 6/6410 16/18639 0.375 1.09042511700468 0.48927422825786 0.829453697904805 GO:0022821 solute:potassium antiporter activity 7/6410 19/18639 0.368421052631579 1.07129485179407 0.496285891183105 0.840295241841704 GO:0005010 insulin-like growth factor receptor activity 18/6410 51/18639 0.352941176470588 1.02628246306323 0.498435219456344 0.841842879949191 GO:0005021 vascular endothelial growth factor receptor activity 18/6410 51/18639 0.352941176470588 1.02628246306323 0.498435219456344 0.841842879949191 GO:0001540 amyloid-beta binding 29/6410 83/18639 0.349397590361446 1.01597842226942 0.499259817826316 0.842020177300205 GO:0019001 guanyl nucleotide binding 138/6410 400/18639 0.345 1.00319110764431 0.500473480469199 0.842020177300205 GO:0032561 guanyl ribonucleotide binding 138/6410 400/18639 0.345 1.00319110764431 0.500473480469199 0.842020177300205 GO:0017069 snRNA binding 19/6410 54/18639 0.351851851851852 1.02311492459698 0.502108958124416 0.842020177300205 GO:0022853 active monoatomic ion transmembrane transporter activity 41/6410 118/18639 0.347457627118644 1.01033739654671 0.502238335314531 0.842020177300205 GO:0008649 rRNA methyltransferase activity 8/6410 22/18639 0.363636363636364 1.0573819316409 0.502246811551773 0.842020177300205 GO:0008235 metalloexopeptidase activity 23/6410 66/18639 0.348484848484849 1.01332435115586 0.515050528508384 0.862390963065529 GO:0044325 transmembrane transporter binding 47/6410 136/18639 0.345588235294118 1.00490157841608 0.515841530561359 0.862390963065529 GO:0005310 dicarboxylic acid transmembrane transporter activity 11/6410 31/18639 0.354838709677419 1.03180011071411 0.516295690287213 0.862390963065529 GO:0008514 organic anion transmembrane transporter activity 92/6410 269/18639 0.342007434944238 0.994489326041443 0.549374511784468 0.909824923363206 GO:0016782 transferase activity, transferring sulphur-containing groups 24/6410 70/18639 0.342857142857143 0.996960106975708 0.552294279313328 0.909824923363206 GO:0004016 adenylate cyclase activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0005114 type II transforming growth factor beta receptor binding 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0008046 axon guidance receptor activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0008271 secondary active sulfate transmembrane transporter activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0008526 phosphatidylinositol transfer activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0015205 nucleobase transmembrane transporter activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0019203 carbohydrate phosphatase activity 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0034713 type I transforming growth factor beta receptor binding 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0048407 platelet-derived growth factor binding 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0050998 nitric-oxide synthase binding 4/6410 11/18639 0.363636363636364 1.0573819316409 0.557456649510915 0.909824923363206 GO:0005347 ATP transmembrane transporter activity 5/6410 14/18639 0.357142857142857 1.03850011143303 0.558212522100675 0.909824923363206 GO:0008195 phosphatidate phosphatase activity 5/6410 14/18639 0.357142857142857 1.03850011143303 0.558212522100675 0.909824923363206 GO:0015386 potassium:proton antiporter activity 5/6410 14/18639 0.357142857142857 1.03850011143303 0.558212522100675 0.909824923363206 GO:0070742 C2H2 zinc finger domain binding 5/6410 14/18639 0.357142857142857 1.03850011143303 0.558212522100675 0.909824923363206 GO:1901612 cardiolipin binding 5/6410 14/18639 0.357142857142857 1.03850011143303 0.558212522100675 0.909824923363206 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/6410 17/18639 0.352941176470588 1.02628246306323 0.55937878633776 0.909824923363206 GO:0016805 dipeptidase activity 6/6410 17/18639 0.352941176470588 1.02628246306323 0.55937878633776 0.909824923363206 GO:0048038 quinone binding 6/6410 17/18639 0.352941176470588 1.02628246306323 0.55937878633776 0.909824923363206 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 7/6410 20/18639 0.35 1.01773010920437 0.560755116783931 0.910471604552953 GO:0016849 phosphorus-oxygen lyase activity 8/6410 23/18639 0.347826086956522 1.01140880417825 0.562241666897169 0.910471604552953 GO:0140102 catalytic activity, acting on a rRNA 8/6410 23/18639 0.347826086956522 1.01140880417825 0.562241666897169 0.910471604552953 GO:0005112 Notch binding 9/6410 26/18639 0.346153846153846 1.00654626185047 0.563784324462724 0.910471604552953 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 9/6410 26/18639 0.346153846153846 1.00654626185047 0.563784324462724 0.910471604552953 GO:0030507 spectrin binding 9/6410 26/18639 0.346153846153846 1.00654626185047 0.563784324462724 0.910471604552953 GO:0004629 phospholipase C activity 10/6410 29/18639 0.344827586206897 1.00268976276292 0.565352027613526 0.910844933377348 GO:0099604 ligand-gated calcium channel activity 10/6410 29/18639 0.344827586206897 1.00268976276292 0.565352027613526 0.910844933377348 GO:0004812 aminoacyl-tRNA ligase activity 14/6410 41/18639 0.341463414634146 0.992907423614018 0.571594213040683 0.917647717755537 GO:0016875 ligase activity, forming carbon-oxygen bonds 14/6410 41/18639 0.341463414634146 0.992907423614018 0.571594213040683 0.917647717755537 GO:0140828 metal cation:monoatomic cation antiporter activity 14/6410 41/18639 0.341463414634146 0.992907423614018 0.571594213040683 0.917647717755537 GO:0005006 epidermal growth factor receptor activity 17/6410 50/18639 0.34 0.988652106084243 0.576098812050202 0.921622864817401 GO:0005017 platelet-derived growth factor receptor activity 17/6410 50/18639 0.34 0.988652106084243 0.576098812050202 0.921622864817401 GO:0005019 platelet-derived growth factor beta-receptor activity 17/6410 50/18639 0.34 0.988652106084243 0.576098812050202 0.921622864817401 GO:0036002 pre-mRNA binding 20/6410 59/18639 0.338983050847458 0.98569502102118 0.580410996675766 0.927432811804301 GO:0016298 lipase activity 44/6410 130/18639 0.338461538461538 0.984178567142686 0.584913924198588 0.933533581595638 GO:0016776 phosphotransferase activity, phosphate group as acceptor 13/6410 39/18639 0.333333333333333 0.969266770670827 0.614499885081275 0.976316010787334 GO:0004190 aspartic-type endopeptidase activity 12/6410 36/18639 0.333333333333333 0.969266770670827 0.614759511047736 0.976316010787334 GO:0005484 SNAP receptor activity 12/6410 36/18639 0.333333333333333 0.969266770670827 0.614759511047736 0.976316010787334 GO:0005030 neurotrophin receptor activity 17/6410 51/18639 0.333333333333333 0.969266770670827 0.614930608347131 0.976316010787334 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 10/6410 30/18639 0.333333333333333 0.969266770670827 0.616017438941385 0.976316010787334 GO:0033612 receptor serine/threonine kinase binding 10/6410 30/18639 0.333333333333333 0.969266770670827 0.616017438941385 0.976316010787334 GO:0035255 ionotropic glutamate receptor binding 9/6410 27/18639 0.333333333333333 0.969266770670827 0.617168469187037 0.977004208480756 GO:0060229 lipase activator activity 8/6410 24/18639 0.333333333333333 0.969266770670827 0.618825636175409 0.978491116133506 GO:0008373 sialyltransferase activity 7/6410 21/18639 0.333333333333333 0.969266770670827 0.621181567486339 0.979942681115602 GO:0015174 basic amino acid transmembrane transporter activity 7/6410 21/18639 0.333333333333333 0.969266770670827 0.621181567486339 0.979942681115602 GO:0098641 cadherin binding involved in cell-cell adhesion 6/6410 18/18639 0.333333333333333 0.969266770670827 0.624539784711294 0.984101417990167 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/6410 15/18639 0.333333333333333 0.969266770670827 0.629410147816229 0.986075898245425 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 5/6410 15/18639 0.333333333333333 0.969266770670827 0.629410147816229 0.986075898245425 GO:0034483 heparan sulfate sulfotransferase activity 5/6410 15/18639 0.333333333333333 0.969266770670827 0.629410147816229 0.986075898245425 GO:0050780 dopamine receptor binding 5/6410 15/18639 0.333333333333333 0.969266770670827 0.629410147816229 0.986075898245425 GO:0051371 muscle alpha-actinin binding 5/6410 15/18639 0.333333333333333 0.969266770670827 0.629410147816229 0.986075898245425 GO:0004000 adenosine deaminase activity 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:0008603 cAMP-dependent protein kinase regulator activity 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:0070679 inositol 1,4,5 trisphosphate binding 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:0140829 bicarbonate:monoatomic anion antiporter activity 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:0140900 chloride:bicarbonate antiporter activity 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:1990817 poly(A) RNA polymerase activity 4/6410 12/18639 0.333333333333333 0.969266770670827 0.6367267279832 0.990706084750115 GO:0019842 vitamin binding 50/6410 150/18639 0.333333333333333 0.969266770670827 0.637578417889042 0.990900095305318 GO:0016500 protein-hormone receptor activity 22/6410 67/18639 0.328358208955224 0.954800102451859 0.650023105800258 0.998717575152636 GO:0016836 hydro-lyase activity 20/6410 61/18639 0.327868852459016 0.953377151479502 0.650503476674273 0.998717575152636 GO:0005253 monoatomic anion channel activity 34/6410 103/18639 0.330097087378641 0.959856413674023 0.651892317497025 0.998717575152636 GO:0004620 phospholipase activity 36/6410 109/18639 0.330275229357798 0.960374414976599 0.652638573930479 0.998717575152636 GO:0005004 GPI-linked ephrin receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0005008 hepatocyte growth factor receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0005009 insulin receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0005011 macrophage colony-stimulating factor receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0005018 platelet-derived growth factor alpha-receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0005020 stem cell factor receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0008288 boss receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0036332 placental growth factor receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0038062 protein tyrosine kinase collagen receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0060175 brain-derived neurotrophic factor receptor activity 16/6410 49/18639 0.326530612244898 0.949485816167341 0.652866734747614 0.998717575152636 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 13/6410 40/18639 0.325 0.945035101404056 0.656620585733257 1 GO:0050997 quaternary ammonium group binding 13/6410 40/18639 0.325 0.945035101404056 0.656620585733257 1 GO:0070001 aspartic-type peptidase activity 12/6410 37/18639 0.324324324324324 0.943070371463507 0.658467401739309 1 GO:0051959 dynein light intermediate chain binding 9/6410 28/18639 0.321428571428571 0.934650100289726 0.666939958897047 1 GO:0061133 endopeptidase activator activity 7/6410 22/18639 0.318181818181818 0.925209190185789 0.676684453589136 1 GO:0052689 carboxylic ester hydrolase activity 30/6410 92/18639 0.326086956521739 0.948195753917113 0.677740978262166 1 GO:0015293 symporter activity 48/6410 146/18639 0.328767123287671 0.955989143675336 0.679669793074612 1 GO:0048029 monosaccharide binding 24/6410 74/18639 0.324324324324324 0.943070371463507 0.679946962363552 1 GO:0005229 intracellularly calcium-gated chloride channel activity 6/6410 19/18639 0.315789473684211 0.918252730109204 0.683733889416613 1 GO:0030506 ankyrin binding 6/6410 19/18639 0.315789473684211 0.918252730109204 0.683733889416613 1 GO:0050145 nucleoside monophosphate kinase activity 6/6410 19/18639 0.315789473684211 0.918252730109204 0.683733889416613 1 GO:0141147 intracellularly calcium-gated channel activity 6/6410 19/18639 0.315789473684211 0.918252730109204 0.683733889416613 1 GO:0005003 ephrin receptor activity 17/6410 53/18639 0.320754716981132 0.932690666117211 0.687231672586336 1 GO:0005005 transmembrane-ephrin receptor activity 17/6410 53/18639 0.320754716981132 0.932690666117211 0.687231672586336 1 GO:0005007 fibroblast growth factor receptor activity 16/6410 50/18639 0.32 0.930496099843994 0.688992816016985 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 5/6410 16/18639 0.3125 0.9086875975039 0.693108293070033 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/6410 16/18639 0.3125 0.9086875975039 0.693108293070033 1 GO:0043023 ribosomal large subunit binding 5/6410 16/18639 0.3125 0.9086875975039 0.693108293070033 1 GO:0019205 nucleobase-containing compound kinase activity 14/6410 44/18639 0.318181818181818 0.925209190185789 0.693372147925299 1 GO:0061631 ubiquitin conjugating enzyme activity 11/6410 35/18639 0.314285714285714 0.913880098061065 0.703000066270703 1 GO:0003964 RNA-directed DNA polymerase activity 4/6410 13/18639 0.307692307692308 0.894707788311533 0.706071201346939 1 GO:0019104 DNA N-glycosylase activity 4/6410 13/18639 0.307692307692308 0.894707788311533 0.706071201346939 1 GO:0030955 potassium ion binding 4/6410 13/18639 0.307692307692308 0.894707788311533 0.706071201346939 1 GO:0140333 glycerophospholipid flippase activity 4/6410 13/18639 0.307692307692308 0.894707788311533 0.706071201346939 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/6410 13/18639 0.307692307692308 0.894707788311533 0.706071201346939 1 GO:0015106 bicarbonate transmembrane transporter activity 10/6410 32/18639 0.3125 0.9086875975039 0.707402965661404 1 GO:0003785 actin monomer binding 9/6410 29/18639 0.310344827586207 0.902420786486632 0.712654527974632 1 GO:0005227 calcium-activated cation channel activity 8/6410 26/18639 0.307692307692308 0.894707788311533 0.718991929235237 1 GO:0008198 ferrous iron binding 8/6410 26/18639 0.307692307692308 0.894707788311533 0.718991929235237 1 GO:0051139 metal cation:proton antiporter activity 8/6410 26/18639 0.307692307692308 0.894707788311533 0.718991929235237 1 GO:0016830 carbon-carbon lyase activity 16/6410 51/18639 0.313725490196078 0.912251078278425 0.722849825237489 1 GO:0015203 polyamine transmembrane transporter activity 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0015279 store-operated calcium channel activity 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0031419 cobalamin binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0031996 thioesterase binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0042166 acetylcholine binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0043121 neurotrophin binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0043208 glycosphingolipid binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0050308 sugar-phosphatase activity 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0141109 transporter activator activity 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:1990763 arrestin family protein binding 3/6410 10/18639 0.3 0.872340093603744 0.725073661788022 1 GO:0043274 phospholipase binding 7/6410 23/18639 0.304347826086957 0.884982703655972 0.726753172766872 1 GO:0099186 structural constituent of postsynapse 7/6410 23/18639 0.304347826086957 0.884982703655972 0.726753172766872 1 GO:0017022 myosin binding 24/6410 76/18639 0.315789473684211 0.918252730109204 0.735678831016279 1 GO:0042288 MHC class I protein binding 6/6410 20/18639 0.3 0.872340093603744 0.736439077687762 1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/6410 39/18639 0.307692307692308 0.894707788311533 0.736951437461217 1 GO:0015294 solute:monoatomic cation symporter activity 37/6410 116/18639 0.318965517241379 0.927488030555705 0.745148341449077 1 GO:0004549 tRNA-specific ribonuclease activity 5/6410 17/18639 0.294117647058824 0.855235385886024 0.748828920875146 1 GO:0045125 bioactive lipid receptor activity 5/6410 17/18639 0.294117647058824 0.855235385886024 0.748828920875146 1 GO:0001968 fibronectin binding 9/6410 30/18639 0.3 0.872340093603744 0.754070423274595 1 GO:0031210 phosphatidylcholine binding 9/6410 30/18639 0.3 0.872340093603744 0.754070423274595 1 GO:0098918 structural constituent of synapse 9/6410 30/18639 0.3 0.872340093603744 0.754070423274595 1 GO:0015103 inorganic anion transmembrane transporter activity 53/6410 165/18639 0.321212121212121 0.934020706282797 0.75620183907589 1 GO:0004364 glutathione transferase activity 8/6410 27/18639 0.296296296296296 0.861570462818513 0.761864965045007 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 14/6410 46/18639 0.304347826086957 0.884982703655972 0.761869223099029 1 GO:0004175 endopeptidase activity 133/6410 405/18639 0.328395061728395 0.954907262957185 0.762545448773251 1 GO:0008494 translation activator activity 4/6410 14/18639 0.285714285714286 0.830800089146423 0.765214673045444 1 GO:0016530 metallochaperone activity 4/6410 14/18639 0.285714285714286 0.830800089146423 0.765214673045444 1 GO:0044548 S100 protein binding 4/6410 14/18639 0.285714285714286 0.830800089146423 0.765214673045444 1 GO:1901474 azole transmembrane transporter activity 4/6410 14/18639 0.285714285714286 0.830800089146423 0.765214673045444 1 GO:0048027 mRNA 5'-UTR binding 7/6410 24/18639 0.291666666666667 0.848108424336974 0.771193923128062 1 GO:0140662 ATP-dependent protein folding chaperone 12/6410 40/18639 0.3 0.872340093603744 0.771378945344629 1 GO:0001786 phosphatidylserine binding 18/6410 59/18639 0.305084745762712 0.887125518919062 0.776242103180043 1 GO:0070888 E-box binding 18/6410 59/18639 0.305084745762712 0.887125518919062 0.776242103180043 1 GO:0030551 cyclic nucleotide binding 11/6410 37/18639 0.297297297297297 0.864481173841548 0.777092971996674 1 GO:0043394 proteoglycan binding 11/6410 37/18639 0.297297297297297 0.864481173841548 0.777092971996674 1 GO:0030170 pyridoxal phosphate binding 17/6410 56/18639 0.303571428571429 0.882725094718074 0.779617026412483 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 41/6410 130/18639 0.315384615384615 0.917075483019321 0.781018663262343 1 GO:0061891 calcium ion sensor activity 6/6410 21/18639 0.285714285714286 0.830800089146423 0.782542081768331 1 GO:0070182 DNA polymerase binding 6/6410 21/18639 0.285714285714286 0.830800089146423 0.782542081768331 1 GO:0008146 sulfotransferase activity 16/6410 53/18639 0.30188679245283 0.877826509286787 0.783323969687686 1 GO:0038064 collagen receptor activity 16/6410 53/18639 0.30188679245283 0.877826509286787 0.783323969687686 1 GO:0016831 carboxy-lyase activity 10/6410 34/18639 0.294117647058824 0.855235385886024 0.783615692087886 1 GO:0003953 NAD+ nucleosidase activity 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0008172 S-methyltransferase activity 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0010854 adenylate cyclase regulator activity 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0043522 leucine zipper domain binding 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0070697 activin receptor binding 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0070990 snRNP binding 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/6410 11/18639 0.272727272727273 0.793036448730676 0.787930041391936 1 GO:0008509 monoatomic anion transmembrane transporter activity 47/6410 149/18639 0.315436241610738 0.917225601775749 0.793324429919447 1 GO:0042562 hormone binding 29/6410 94/18639 0.308510638297872 0.897087330301723 0.796563092570531 1 GO:0003746 translation elongation factor activity 5/6410 18/18639 0.277777777777778 0.807722308892356 0.79663243478432 1 GO:0031690 adrenergic receptor binding 5/6410 18/18639 0.277777777777778 0.807722308892356 0.79663243478432 1 GO:0070628 proteasome binding 5/6410 18/18639 0.277777777777778 0.807722308892356 0.79663243478432 1 GO:1901611 phosphatidylglycerol binding 5/6410 18/18639 0.277777777777778 0.807722308892356 0.79663243478432 1 GO:0051393 alpha-actinin binding 8/6410 28/18639 0.285714285714286 0.830800089146423 0.79983496750419 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 12/6410 41/18639 0.292682926829268 0.851063505954872 0.80253004717884 1 GO:0070279 vitamin B6 binding 17/6410 57/18639 0.298245614035088 0.867238689547582 0.805799577380481 1 GO:0016835 carbon-oxygen lyase activity 24/6410 79/18639 0.30379746835443 0.883382373269614 0.807181788890532 1 GO:0005537 D-mannose binding 7/6410 25/18639 0.28 0.814184087363495 0.810066548674547 1 GO:0004129 cytochrome-c oxidase activity 4/6410 15/18639 0.266666666666667 0.775413416536661 0.814598136765158 1 GO:0005523 tropomyosin binding 4/6410 15/18639 0.266666666666667 0.775413416536661 0.814598136765158 1 GO:0008252 nucleotidase activity 4/6410 15/18639 0.266666666666667 0.775413416536661 0.814598136765158 1 GO:0015116 sulfate transmembrane transporter activity 4/6410 15/18639 0.266666666666667 0.775413416536661 0.814598136765158 1 GO:0033130 acetylcholine receptor binding 4/6410 15/18639 0.266666666666667 0.775413416536661 0.814598136765158 1 GO:1901681 sulfur compound binding 88/6410 275/18639 0.32 0.930496099843994 0.816855834151155 1 GO:0031683 G-protein beta/gamma-subunit complex binding 6/6410 22/18639 0.272727272727273 0.793036448730676 0.822238692335529 1 GO:0140784 metal ion sensor activity 6/6410 22/18639 0.272727272727273 0.793036448730676 0.822238692335529 1 GO:0008135 translation factor activity, RNA binding 25/6410 83/18639 0.301204819277108 0.875843467473639 0.825121163689307 1 GO:0046943 carboxylic acid transmembrane transporter activity 59/6410 188/18639 0.313829787234043 0.912554353237959 0.828658455179409 1 GO:0015171 amino acid transmembrane transporter activity 31/6410 102/18639 0.303921568627451 0.883743232082224 0.830473395642561 1 GO:0042277 peptide binding 79/6410 249/18639 0.317269076305221 0.922555119072233 0.830804193809015 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/6410 19/18639 0.263157894736842 0.765210608424337 0.836953343844216 1 GO:0008301 DNA binding, bending 5/6410 19/18639 0.263157894736842 0.765210608424337 0.836953343844216 1 GO:0003720 telomerase activity 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0005436 sodium:phosphate symporter activity 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0008504 monoamine transmembrane transporter activity 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0016208 AMP binding 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0016801 hydrolase activity, acting on ether bonds 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0016803 ether hydrolase activity 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0042301 phosphate ion binding 3/6410 12/18639 0.25 0.72695007800312 0.838331145861515 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 20/6410 68/18639 0.294117647058824 0.855235385886024 0.839823956212999 1 GO:0005342 organic acid transmembrane transporter activity 59/6410 189/18639 0.312169312169312 0.907726023326647 0.841382429123858 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/6410 26/18639 0.269230769230769 0.782869314772591 0.843620355836398 1 GO:0004435 phosphatidylinositol phospholipase C activity 7/6410 26/18639 0.269230769230769 0.782869314772591 0.843620355836398 1 GO:0030247 polysaccharide binding 7/6410 26/18639 0.269230769230769 0.782869314772591 0.843620355836398 1 GO:0120014 phospholipid transfer activity 7/6410 26/18639 0.269230769230769 0.782869314772591 0.843620355836398 1 GO:0035254 glutamate receptor binding 14/6410 49/18639 0.285714285714286 0.830800089146423 0.843697383291637 1 GO:0180051 translation factor activity 25/6410 84/18639 0.297619047619048 0.865416759527524 0.843893866617313 1 GO:0030296 protein tyrosine kinase activator activity 9/6410 33/18639 0.272727272727273 0.793036448730676 0.852532024937013 1 GO:0005149 interleukin-1 receptor binding 4/6410 16/18639 0.25 0.72695007800312 0.8550947513302 1 GO:0015385 sodium:proton antiporter activity 4/6410 16/18639 0.25 0.72695007800312 0.8550947513302 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/6410 16/18639 0.25 0.72695007800312 0.8550947513302 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/6410 16/18639 0.25 0.72695007800312 0.8550947513302 1 GO:0004602 glutathione peroxidase activity 6/6410 23/18639 0.260869565217391 0.75855660313369 0.855939463947997 1 GO:0005283 amino acid:sodium symporter activity 6/6410 23/18639 0.260869565217391 0.75855660313369 0.855939463947997 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/6410 23/18639 0.260869565217391 0.75855660313369 0.855939463947997 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 26/6410 88/18639 0.295454545454545 0.859122819458233 0.858508075874934 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 8/6410 30/18639 0.266666666666667 0.775413416536661 0.86176515996667 1 GO:0022839 monoatomic ion-gated channel activity 8/6410 30/18639 0.266666666666667 0.775413416536661 0.86176515996667 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 11/6410 40/18639 0.275 0.799645085803432 0.861921114904636 1 GO:0015078 proton transmembrane transporter activity 57/6410 185/18639 0.308108108108108 0.895916852890332 0.86647927556426 1 GO:0042805 actinin binding 10/6410 37/18639 0.27027027027027 0.785891976219589 0.869242660494109 1 GO:0005326 neurotransmitter transmembrane transporter activity 5/6410 20/18639 0.25 0.72695007800312 0.870458099229701 1 GO:0016408 C-acyltransferase activity 5/6410 20/18639 0.25 0.72695007800312 0.870458099229701 1 GO:0005044 scavenger receptor activity 7/6410 27/18639 0.259259259259259 0.753874154966199 0.872234742613385 1 GO:0033218 amide binding 77/6410 247/18639 0.311740890688259 0.906480259210368 0.873046383902309 1 GO:0016248 channel inhibitor activity 12/6410 44/18639 0.272727272727273 0.793036448730676 0.877154120403589 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0005035 death receptor activity 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0005172 vascular endothelial growth factor receptor binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0005542 folic acid binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0008253 5'-nucleotidase activity 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0019855 calcium channel inhibitor activity 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0035325 Toll-like receptor binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0039706 co-receptor binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0089720 caspase binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:1901338 catecholamine binding 3/6410 13/18639 0.230769230769231 0.671030841233649 0.878009129215888 1 GO:0005254 chloride channel activity 24/6410 83/18639 0.289156626506024 0.840809728774693 0.879669593932353 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/6410 24/18639 0.25 0.72695007800312 0.884187977554642 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/6410 24/18639 0.25 0.72695007800312 0.884187977554642 1 GO:0008429 phosphatidylethanolamine binding 4/6410 17/18639 0.235294117647059 0.684188308708819 0.887791929931755 1 GO:0009881 photoreceptor activity 4/6410 17/18639 0.235294117647059 0.684188308708819 0.887791929931755 1 GO:0031489 myosin V binding 4/6410 17/18639 0.235294117647059 0.684188308708819 0.887791929931755 1 GO:0015026 coreceptor activity 17/6410 61/18639 0.278688524590164 0.810370578757576 0.88817952287221 1 GO:0015085 calcium ion transmembrane transporter activity 44/6410 147/18639 0.299319727891156 0.870361998153396 0.891556404123755 1 GO:0141110 transporter inhibitor activity 12/6410 45/18639 0.266666666666667 0.775413416536661 0.896287059326705 1 GO:0016866 intramolecular transferase activity 7/6410 28/18639 0.25 0.72695007800312 0.896368000983116 1 GO:0046625 sphingolipid binding 7/6410 28/18639 0.25 0.72695007800312 0.896368000983116 1 GO:0009975 cyclase activity 5/6410 21/18639 0.238095238095238 0.692333407622019 0.897931854686378 1 GO:0019200 carbohydrate kinase activity 5/6410 21/18639 0.238095238095238 0.692333407622019 0.897931854686378 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/6410 21/18639 0.238095238095238 0.692333407622019 0.897931854686378 1 GO:0005343 organic acid:sodium symporter activity 9/6410 35/18639 0.257142857142857 0.747720080231781 0.898623430190832 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0004935 adrenergic receptor activity 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0005031 tumor necrosis factor receptor activity 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0005528 FK506 binding 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0015187 glycine transmembrane transporter activity 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0019531 oxalate transmembrane transporter activity 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0035256 G protein-coupled glutamate receptor binding 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0035374 chondroitin sulfate binding 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/6410 10/18639 0.2 0.581560062402496 0.907806417037916 1 GO:0031404 chloride ion binding 3/6410 14/18639 0.214285714285714 0.623100066859817 0.908771253626009 1 GO:1990825 sequence-specific mRNA binding 3/6410 14/18639 0.214285714285714 0.623100066859817 0.908771253626009 1 GO:0004180 carboxypeptidase activity 12/6410 46/18639 0.260869565217391 0.75855660313369 0.912896685992779 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/6410 18/18639 0.222222222222222 0.646177847113885 0.91383749997388 1 GO:0005416 amino acid:monoatomic cation symporter activity 7/6410 29/18639 0.241379310344828 0.701882833934047 0.916515731086464 1 GO:0045505 dynein intermediate chain binding 9/6410 36/18639 0.25 0.72695007800312 0.916718793828247 1 GO:0017046 peptide hormone binding 14/6410 53/18639 0.264150943396226 0.768098195625938 0.917008323596134 1 GO:0005507 copper ion binding 17/6410 63/18639 0.26984126984127 0.784644528638288 0.91734140737691 1 GO:0016829 lyase activity 60/6410 200/18639 0.3 0.872340093603744 0.918785682297702 1 GO:0008200 ion channel inhibitor activity 11/6410 43/18639 0.255813953488372 0.743855893770635 0.918853252995637 1 GO:0008970 phospholipase A1 activity 5/6410 22/18639 0.227272727272727 0.660863707275564 0.920194549495452 1 GO:0015377 chloride:monoatomic cation symporter activity 5/6410 22/18639 0.227272727272727 0.660863707275564 0.920194549495452 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/6410 22/18639 0.227272727272727 0.660863707275564 0.920194549495452 1 GO:0015145 monosaccharide transmembrane transporter activity 6/6410 26/18639 0.230769230769231 0.671030841233649 0.926787061189311 1 GO:0004222 metalloendopeptidase activity 31/6410 110/18639 0.281818181818182 0.819470997021699 0.931874416105236 1 GO:0017081 chloride channel regulator activity 3/6410 15/18639 0.2 0.581560062402496 0.932314532841222 1 GO:0031005 filamin binding 3/6410 15/18639 0.2 0.581560062402496 0.932314532841222 1 GO:0045504 dynein heavy chain binding 3/6410 15/18639 0.2 0.581560062402496 0.932314532841222 1 GO:0050700 CARD domain binding 3/6410 15/18639 0.2 0.581560062402496 0.932314532841222 1 GO:0003954 NADH dehydrogenase activity 11/6410 44/18639 0.25 0.72695007800312 0.932752963859653 1 GO:0022840 leak channel activity 4/6410 19/18639 0.210526315789474 0.61216848673947 0.934339941608456 1 GO:0022842 narrow pore channel activity 4/6410 19/18639 0.210526315789474 0.61216848673947 0.934339941608456 1 GO:0043395 heparan sulfate proteoglycan binding 4/6410 19/18639 0.210526315789474 0.61216848673947 0.934339941608456 1 GO:0070003 threonine-type peptidase activity 4/6410 19/18639 0.210526315789474 0.61216848673947 0.934339941608456 1 GO:0097001 ceramide binding 4/6410 19/18639 0.210526315789474 0.61216848673947 0.934339941608456 1 GO:0008503 benzodiazepine receptor activity 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0015217 ADP transmembrane transporter activity 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0016594 glycine binding 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0019206 nucleoside kinase activity 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0042608 T cell receptor binding 2/6410 11/18639 0.181818181818182 0.528690965820451 0.934445611625912 1 GO:0003743 translation initiation factor activity 13/6410 51/18639 0.254901960784314 0.741204001101221 0.934622048601246 1 GO:0008237 metallopeptidase activity 54/6410 184/18639 0.293478260869565 0.853376178525402 0.937866225877115 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 10/6410 41/18639 0.24390243902439 0.709219588295727 0.938596150804185 1 GO:0017080 sodium channel regulator activity 10/6410 41/18639 0.24390243902439 0.709219588295727 0.938596150804185 1 GO:0015020 glucuronosyltransferase activity 8/6410 34/18639 0.235294117647059 0.684188308708819 0.939188637126087 1 GO:0015252 proton channel activity 6/6410 27/18639 0.222222222222222 0.646177847113885 0.94237343792529 1 GO:0019955 cytokine binding 41/6410 144/18639 0.284722222222222 0.827915366614665 0.945745277303121 1 GO:0005164 tumor necrosis factor receptor binding 7/6410 31/18639 0.225806451612903 0.656600070454431 0.946841103142995 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/6410 59/18639 0.254237288135593 0.739271265765885 0.94706090140361 1 GO:0008307 structural constituent of muscle 10/6410 42/18639 0.238095238095238 0.692333407622019 0.949848194007625 1 GO:0016859 cis-trans isomerase activity 10/6410 42/18639 0.238095238095238 0.692333407622019 0.949848194007625 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/6410 16/18639 0.1875 0.54521255850234 0.950134482420689 1 GO:0001614 purinergic nucleotide receptor activity 4/6410 20/18639 0.2 0.581560062402496 0.950310402203145 1 GO:0016502 nucleotide receptor activity 4/6410 20/18639 0.2 0.581560062402496 0.950310402203145 1 GO:0019212 phosphatase inhibitor activity 14/6410 56/18639 0.25 0.72695007800312 0.950832032106471 1 GO:0016229 steroid dehydrogenase activity 8/6410 35/18639 0.228571428571429 0.664640071317138 0.951207957699496 1 GO:0004806 triacylglycerol lipase activity 5/6410 24/18639 0.208333333333333 0.605791731669267 0.952215607215825 1 GO:0015149 hexose transmembrane transporter activity 5/6410 24/18639 0.208333333333333 0.605791731669267 0.952215607215825 1 GO:0055056 D-glucose transmembrane transporter activity 5/6410 24/18639 0.208333333333333 0.605791731669267 0.952215607215825 1 GO:0004526 ribonuclease P activity 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0005527 macrolide binding 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0008179 adenylate cyclase binding 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0015166 polyol transmembrane transporter activity 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0015269 calcium-activated potassium channel activity 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0016840 carbon-nitrogen lyase activity 2/6410 12/18639 0.166666666666667 0.484633385335413 0.953668504778791 1 GO:0070851 growth factor receptor binding 39/6410 139/18639 0.280575539568345 0.815857641499904 0.954149862652598 1 GO:0031406 carboxylic acid binding 54/6410 187/18639 0.288770053475936 0.839685651597187 0.954375920812302 1 GO:0004864 protein phosphatase inhibitor activity 13/6410 53/18639 0.245283018867925 0.713234038795514 0.954723165720061 1 GO:0005544 calcium-dependent phospholipid binding 13/6410 53/18639 0.245283018867925 0.713234038795514 0.954723165720061 1 GO:0051119 sugar transmembrane transporter activity 6/6410 28/18639 0.214285714285714 0.623100066859817 0.954920375273156 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 9/6410 39/18639 0.230769230769231 0.671030841233649 0.955358490480451 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/6410 32/18639 0.21875 0.63608131825273 0.95795276385649 1 GO:0071813 lipoprotein particle binding 7/6410 32/18639 0.21875 0.63608131825273 0.95795276385649 1 GO:0071814 protein-lipid complex binding 7/6410 32/18639 0.21875 0.63608131825273 0.95795276385649 1 GO:0004033 aldo-keto reductase (NADPH) activity 8/6410 36/18639 0.222222222222222 0.646177847113885 0.961062004519853 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/6410 36/18639 0.222222222222222 0.646177847113885 0.961062004519853 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/6410 36/18639 0.222222222222222 0.646177847113885 0.961062004519853 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/6410 36/18639 0.222222222222222 0.646177847113885 0.961062004519853 1 GO:0015108 chloride transmembrane transporter activity 33/6410 121/18639 0.272727272727273 0.793036448730676 0.961963044973141 1 GO:0005248 voltage-gated sodium channel activity 4/6410 21/18639 0.19047619047619 0.553866726097615 0.962634766324738 1 GO:0005262 calcium channel activity 36/6410 131/18639 0.274809160305344 0.799090162079766 0.963010631400812 1 GO:0043177 organic acid binding 54/6410 189/18639 0.285714285714286 0.830800089146423 0.963189716780335 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 5/6410 25/18639 0.2 0.581560062402496 0.963370822877429 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0008569 minus-end-directed microtubule motor activity 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0016018 cyclosporin A binding 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0030169 low-density lipoprotein particle binding 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0036041 long-chain fatty acid binding 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0070492 oligosaccharide binding 3/6410 17/18639 0.176470588235294 0.513141231531614 0.963493600811174 1 GO:0015144 carbohydrate transmembrane transporter activity 9/6410 40/18639 0.225 0.654255070202808 0.964112346764126 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 14/6410 58/18639 0.241379310344828 0.701882833934047 0.966044241810845 1 GO:0019956 chemokine binding 7/6410 33/18639 0.212121212121212 0.616806126790526 0.966922536677967 1 GO:0004465 lipoprotein lipase activity 2/6410 13/18639 0.153846153846154 0.447353894155766 0.967424754881137 1 GO:0008035 high-density lipoprotein particle binding 2/6410 13/18639 0.153846153846154 0.447353894155766 0.967424754881137 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/6410 13/18639 0.153846153846154 0.447353894155766 0.967424754881137 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/6410 13/18639 0.153846153846154 0.447353894155766 0.967424754881137 1 GO:0071837 HMG box domain binding 2/6410 13/18639 0.153846153846154 0.447353894155766 0.967424754881137 1 GO:0016209 antioxidant activity 22/6410 86/18639 0.255813953488372 0.743855893770635 0.969421375096679 1 GO:0042287 MHC protein binding 9/6410 41/18639 0.219512195121951 0.638297629466154 0.971288776877859 1 GO:0005243 gap junction channel activity 4/6410 22/18639 0.181818181818182 0.528690965820451 0.972065925620134 1 GO:0048306 calcium-dependent protein binding 20/6410 80/18639 0.25 0.72695007800312 0.973171731542906 1 GO:0015280 ligand-gated sodium channel activity 3/6410 18/18639 0.166666666666667 0.484633385335413 0.973424820978633 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/6410 18/18639 0.166666666666667 0.484633385335413 0.973424820978633 1 GO:0022851 GABA-gated chloride ion channel activity 3/6410 18/18639 0.166666666666667 0.484633385335413 0.973424820978633 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/6410 18/18639 0.166666666666667 0.484633385335413 0.973424820978633 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 7/6410 34/18639 0.205882352941176 0.598664770120216 0.974112806932158 1 GO:0170055 lipid transmembrane transporter activity 13/6410 56/18639 0.232142857142857 0.675025072431469 0.974724708798055 1 GO:0031492 nucleosomal DNA binding 9/6410 42/18639 0.214285714285714 0.623100066859817 0.977136208569741 1 GO:0005344 oxygen carrier activity 2/6410 14/18639 0.142857142857143 0.415400044573212 0.977200338423659 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/6410 14/18639 0.142857142857143 0.415400044573212 0.977200338423659 1 GO:0043176 amine binding 2/6410 14/18639 0.142857142857143 0.415400044573212 0.977200338423659 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/6410 27/18639 0.185185185185185 0.53848153926157 0.978833016054638 1 GO:0047499 calcium-independent phospholipase A2 activity 6/6410 31/18639 0.193548387096774 0.562800060389512 0.979128077308628 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 35/6410 132/18639 0.265151515151515 0.771007658488158 0.979224483231038 1 GO:0031681 G-protein beta-subunit binding 4/6410 23/18639 0.173913043478261 0.505704402089127 0.979228607988637 1 GO:0004601 peroxidase activity 13/6410 57/18639 0.228070175438596 0.663182527301092 0.979353854273303 1 GO:0004890 GABA-A receptor activity 3/6410 19/18639 0.157894736842105 0.459126365054602 0.980753235860541 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/6410 19/18639 0.157894736842105 0.459126365054602 0.980753235860541 1 GO:0004896 cytokine receptor activity 24/6410 96/18639 0.25 0.72695007800312 0.981891271802203 1 GO:0015370 solute:sodium symporter activity 19/6410 79/18639 0.240506329113924 0.699344378838445 0.982520398683234 1 GO:0099095 ligand-gated monoatomic anion channel activity 10/6410 47/18639 0.212765957446809 0.618680917449464 0.983012014158962 1 GO:0047498 calcium-dependent phospholipase A2 activity 6/6410 32/18639 0.1875 0.54521255850234 0.984014688105276 1 GO:0051537 2 iron, 2 sulfur cluster binding 5/6410 28/18639 0.178571428571429 0.519250055716514 0.984031416224526 1 GO:0004089 carbonate dehydratase activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0008020 G protein-coupled photoreceptor activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0016846 carbon-sulfur lyase activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0030553 cGMP binding 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0031386 protein tag activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0140161 monocarboxylate:sodium symporter activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0141047 molecular tag activity 2/6410 15/18639 0.133333333333333 0.387706708268331 0.984105846974803 1 GO:0019957 C-C chemokine binding 4/6410 24/18639 0.166666666666667 0.484633385335413 0.9846312081432 1 GO:0004955 prostaglandin receptor activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0008519 ammonium channel activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0016868 intramolecular phosphotransferase activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0032052 bile acid binding 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0033204 ribonuclease P RNA binding 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0047429 nucleoside triphosphate diphosphatase activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0051378 serotonin binding 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/6410 10/18639 0.1 0.290780031201248 0.985238396438723 1 GO:0001972 retinoic acid binding 3/6410 20/18639 0.15 0.436170046801872 0.986125500623611 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/6410 20/18639 0.15 0.436170046801872 0.986125500623611 1 GO:0010851 cyclase regulator activity 3/6410 20/18639 0.15 0.436170046801872 0.986125500623611 1 GO:0015464 acetylcholine receptor activity 3/6410 20/18639 0.15 0.436170046801872 0.986125500623611 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 16/6410 70/18639 0.228571428571429 0.664640071317138 0.986964662694329 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 31/6410 122/18639 0.254098360655738 0.738867292396614 0.987361621611374 1 GO:0008201 heparin binding 46/6410 172/18639 0.267441860465116 0.777667525305663 0.987441244860791 1 GO:0019239 deaminase activity 6/6410 33/18639 0.181818181818182 0.528690965820451 0.987812943978011 1 GO:0022829 wide pore channel activity 7/6410 37/18639 0.189189189189189 0.550124383353713 0.987938250737039 1 GO:0004181 metallocarboxypeptidase activity 5/6410 29/18639 0.172413793103448 0.501344881381462 0.988009007499538 1 GO:0015378 sodium:chloride symporter activity 2/6410 16/18639 0.125 0.36347503900156 0.988958899053962 1 GO:0022841 potassium ion leak channel activity 2/6410 16/18639 0.125 0.36347503900156 0.988958899053962 1 GO:0055102 lipase inhibitor activity 2/6410 16/18639 0.125 0.36347503900156 0.988958899053962 1 GO:0036122 BMP binding 3/6410 21/18639 0.142857142857143 0.415400044573212 0.990040623006757 1 GO:0051428 peptide hormone receptor binding 3/6410 21/18639 0.142857142857143 0.415400044573212 0.990040623006757 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0004954 prostanoid receptor activity 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0005536 D-glucose binding 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0008199 ferric iron binding 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0031731 CCR6 chemokine receptor binding 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0050786 RAGE receptor binding 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:1990948 ubiquitin ligase inhibitor activity 1/6410 11/18639 0.0909090909090909 0.264345482910226 0.990317674920004 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/6410 34/18639 0.176470588235294 0.513141231531614 0.990748687630694 1 GO:0051427 hormone receptor binding 6/6410 34/18639 0.176470588235294 0.513141231531614 0.990748687630694 1 GO:0004550 nucleoside diphosphate kinase activity 2/6410 17/18639 0.117647058823529 0.342094154354409 0.992354272153 1 GO:0004623 phospholipase A2 activity 6/6410 35/18639 0.171428571428571 0.498480053487854 0.993005860401115 1 GO:0005200 structural constituent of cytoskeleton 27/6410 112/18639 0.241071428571429 0.700987575217294 0.993058767396428 1 GO:0005272 sodium channel activity 10/6410 51/18639 0.196078431372549 0.570156923924016 0.993365982282426 1 GO:0004126 cytidine deaminase activity 1/6410 12/18639 0.0833333333333333 0.242316692667707 0.993649417660114 1 GO:0004859 phospholipase inhibitor activity 1/6410 12/18639 0.0833333333333333 0.242316692667707 0.993649417660114 1 GO:0015132 prostaglandin transmembrane transporter activity 1/6410 12/18639 0.0833333333333333 0.242316692667707 0.993649417660114 1 GO:0015081 sodium ion transmembrane transporter activity 42/6410 164/18639 0.25609756097561 0.744680567710513 0.99401260692667 1 GO:0005506 iron ion binding 39/6410 154/18639 0.253246753246753 0.736390988107057 0.994104341358125 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/6410 44/18639 0.181818181818182 0.528690965820451 0.994574765070485 1 GO:0015373 monoatomic anion:sodium symporter activity 2/6410 18/18639 0.111111111111111 0.323088923556942 0.994720453549796 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/6410 23/18639 0.130434782608696 0.379278301566845 0.994926251890204 1 GO:0005212 structural constituent of eye lens 3/6410 23/18639 0.130434782608696 0.379278301566845 0.994926251890204 1 GO:0016493 C-C chemokine receptor activity 3/6410 23/18639 0.130434782608696 0.379278301566845 0.994926251890204 1 GO:0016917 GABA receptor activity 3/6410 23/18639 0.130434782608696 0.379278301566845 0.994926251890204 1 GO:0071714 icosanoid transmembrane transporter activity 1/6410 13/18639 0.0769230769230769 0.223676947077883 0.995834806225029 1 GO:0001530 lipopolysaccharide binding 7/6410 41/18639 0.170731707317073 0.496453711807009 0.995888825113027 1 GO:0005246 calcium channel regulator activity 10/6410 53/18639 0.188679245283019 0.548641568304242 0.995942591447697 1 GO:0042834 peptidoglycan binding 2/6410 19/18639 0.105263157894737 0.306084243369735 0.996363655630885 1 GO:0009055 electron transfer activity 27/6410 116/18639 0.232758620689655 0.676815589864974 0.996571893776657 1 GO:0008191 metalloendopeptidase inhibitor activity 1/6410 14/18639 0.0714285714285714 0.207700022286606 0.997268226825134 1 GO:0008392 arachidonate epoxygenase activity 1/6410 14/18639 0.0714285714285714 0.207700022286606 0.997268226825134 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/6410 14/18639 0.0714285714285714 0.207700022286606 0.997268226825134 1 GO:0030627 pre-mRNA 5'-splice site binding 2/6410 20/18639 0.1 0.290780031201248 0.997501228409471 1 GO:0030246 carbohydrate binding 75/6410 280/18639 0.267857142857143 0.778875083574772 0.997548079325231 1 GO:0005245 voltage-gated calcium channel activity 7/6410 43/18639 0.162790697674419 0.473362841490404 0.997650988054187 1 GO:0048019 receptor antagonist activity 4/6410 30/18639 0.133333333333333 0.387706708268331 0.997686712992197 1 GO:0046982 protein heterodimerization activity 102/6410 369/18639 0.276422764227642 0.803782200068491 0.997857125280288 1 GO:0017171 serine hydrolase activity 50/6410 198/18639 0.252525252525253 0.73429300808396 0.997891269653899 1 GO:0033293 monocarboxylic acid binding 16/6410 79/18639 0.20253164556962 0.588921582179743 0.998046490504523 1 GO:0038187 pattern recognition receptor activity 8/6410 48/18639 0.166666666666667 0.484633385335413 0.998151728865716 1 GO:0001637 G protein-coupled chemoattractant receptor activity 3/6410 26/18639 0.115384615384615 0.335515420616825 0.998199212158044 1 GO:0004950 chemokine receptor activity 3/6410 26/18639 0.115384615384615 0.335515420616825 0.998199212158044 1 GO:0004953 icosanoid receptor activity 1/6410 15/18639 0.0666666666666667 0.193853354134165 0.998208396814444 1 GO:0001846 opsonin binding 2/6410 21/18639 0.0952380952380952 0.276933363048808 0.998286555293967 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/6410 36/18639 0.138888888888889 0.403861154446178 0.998552291476485 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 5/6410 36/18639 0.138888888888889 0.403861154446178 0.998552291476485 1 GO:0019843 rRNA binding 12/6410 65/18639 0.184615384615385 0.536824672986919 0.998566609265613 1 GO:0005104 fibroblast growth factor receptor binding 3/6410 27/18639 0.111111111111111 0.323088923556942 0.998732056918356 1 GO:0023026 MHC class II protein complex binding 3/6410 27/18639 0.111111111111111 0.323088923556942 0.998732056918356 1 GO:0008391 arachidonate monooxygenase activity 1/6410 16/18639 0.0625 0.18173751950078 0.998825029998476 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/6410 16/18639 0.0625 0.18173751950078 0.998825029998476 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/6410 16/18639 0.0625 0.18173751950078 0.998825029998476 1 GO:0033038 bitter taste receptor activity 2/6410 22/18639 0.0909090909090909 0.264345482910226 0.99882733751132 1 GO:0033691 sialic acid binding 2/6410 22/18639 0.0909090909090909 0.264345482910226 0.99882733751132 1 GO:0023023 MHC protein complex binding 5/6410 37/18639 0.135135135135135 0.392945988109795 0.998943615639553 1 GO:0042056 chemoattractant activity 6/6410 42/18639 0.142857142857143 0.415400044573212 0.999105159495853 1 GO:0015459 potassium channel regulator activity 10/6410 59/18639 0.169491525423729 0.49284751051059 0.999138564250821 1 GO:0004857 enzyme inhibitor activity 114/6410 416/18639 0.274038461538462 0.796849123964959 0.99914963900954 1 GO:0008236 serine-type peptidase activity 47/6410 194/18639 0.242268041237113 0.704467085899931 0.999196886520856 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/6410 17/18639 0.0588235294117647 0.171047077177205 0.999229452363818 1 GO:0030548 acetylcholine receptor regulator activity 1/6410 17/18639 0.0588235294117647 0.171047077177205 0.999229452363818 1 GO:0045236 CXCR chemokine receptor binding 1/6410 17/18639 0.0588235294117647 0.171047077177205 0.999229452363818 1 GO:0005504 fatty acid binding 7/6410 47/18639 0.148936170212766 0.433076642214625 0.99926108311713 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 8/6410 52/18639 0.153846153846154 0.447353894155766 0.999400204661902 1 GO:0005540 hyaluronic acid binding 2/6410 24/18639 0.0833333333333333 0.242316692667707 0.999453587388849 1 GO:0005372 water transmembrane transporter activity 1/6410 18/18639 0.0555555555555556 0.161544461778471 0.999494687588173 1 GO:0032393 MHC class I receptor activity 1/6410 18/18639 0.0555555555555556 0.161544461778471 0.999494687588173 1 GO:0099602 neurotransmitter receptor regulator activity 1/6410 18/18639 0.0555555555555556 0.161544461778471 0.999494687588173 1 GO:0046873 metal ion transmembrane transporter activity 123/6410 450/18639 0.273333333333333 0.794798751950078 0.999509801351333 1 GO:0001848 complement binding 2/6410 25/18639 0.08 0.232624024960998 0.999627883941923 1 GO:0005251 delayed rectifier potassium channel activity 2/6410 25/18639 0.08 0.232624024960998 0.999627883941923 1 GO:0015271 outward rectifier potassium channel activity 2/6410 25/18639 0.08 0.232624024960998 0.999627883941923 1 GO:0016918 retinal binding 1/6410 19/18639 0.0526315789473684 0.153042121684867 0.999668633808022 1 GO:0034987 immunoglobulin receptor binding 1/6410 19/18639 0.0526315789473684 0.153042121684867 0.999668633808022 1 GO:0008227 G protein-coupled amine receptor activity 5/6410 41/18639 0.121951219512195 0.354609794147863 0.99970833171177 1 GO:0004867 serine-type endopeptidase inhibitor activity 18/6410 95/18639 0.189473684210526 0.550951638065523 0.999714284204042 1 GO:0008395 steroid hydroxylase activity 2/6410 27/18639 0.0740740740740741 0.215392615704628 0.999828130564357 1 GO:0005539 glycosaminoglycan binding 58/6410 242/18639 0.239669421487603 0.696910818581504 0.999842989420429 1 GO:0005501 retinoid binding 4/6410 38/18639 0.105263157894737 0.306084243369735 0.999843444196794 1 GO:0019840 isoprenoid binding 4/6410 38/18639 0.105263157894737 0.306084243369735 0.999843444196794 1 GO:0015125 bile acid transmembrane transporter activity 1/6410 21/18639 0.0476190476190476 0.138466681524404 0.999857515400487 1 GO:0005242 inward rectifier potassium channel activity 2/6410 28/18639 0.0714285714285714 0.207700022286606 0.999883415338348 1 GO:0008527 taste receptor activity 2/6410 28/18639 0.0714285714285714 0.207700022286606 0.999883415338348 1 GO:0005201 extracellular matrix structural constituent 36/6410 168/18639 0.214285714285714 0.623100066859817 0.999919364842954 1 GO:0042605 peptide antigen binding 5/6410 45/18639 0.111111111111111 0.323088923556942 0.999922378278094 1 GO:0004252 serine-type endopeptidase activity 38/6410 176/18639 0.215909090909091 0.627820521911786 0.999930268688478 1 GO:0061134 peptidase regulator activity 52/6410 226/18639 0.230088495575221 0.66905139922411 0.999931280647765 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/6410 46/18639 0.108695652173913 0.316065251305704 0.999944527329094 1 GO:0141108 transporter regulator activity 36/6410 170/18639 0.211764705882353 0.615769477837937 0.999945783925678 1 GO:0046906 tetrapyrrole binding 31/6410 152/18639 0.203947368421053 0.593038221528861 0.999950280022503 1 GO:0099106 ion channel regulator activity 33/6410 160/18639 0.20625 0.599733814352574 0.999956001887065 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/6410 24/18639 0.0416666666666667 0.121158346333853 0.999959833345388 1 GO:0016247 channel regulator activity 35/6410 168/18639 0.208333333333333 0.605791731669267 0.999961286428652 1 GO:0020037 heme binding 28/6410 142/18639 0.197183098591549 0.573369075608095 0.999961857494886 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/6410 25/18639 0.04 0.116312012480499 0.999973664570532 1 GO:0030547 signaling receptor inhibitor activity 4/6410 44/18639 0.0909090909090909 0.264345482910226 0.999980953286337 1 GO:0019865 immunoglobulin binding 1/6410 26/18639 0.0384615384615385 0.111838473538942 0.999982733556397 1 GO:0071855 neuropeptide receptor binding 3/6410 40/18639 0.075 0.218085023400936 0.999988904562124 1 GO:0099094 ligand-gated monoatomic cation channel activity 25/6410 136/18639 0.183823529411765 0.534522116178765 0.999989047561744 1 GO:0030280 structural constituent of skin epidermis 2/6410 37/18639 0.0540540540540541 0.157178395243918 0.999996608416676 1 GO:0005184 neuropeptide hormone activity 1/6410 31/18639 0.032258064516129 0.0938000100649187 0.999997909108601 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 5/6410 56/18639 0.0892857142857143 0.259625027858257 0.999998238873432 1 GO:0005126 cytokine receptor binding 60/6410 275/18639 0.218181818181818 0.634429158984541 0.999998352813734 1 GO:0001664 G protein-coupled receptor binding 66/6410 297/18639 0.222222222222222 0.646177847113885 0.999998504018018 1 GO:0160041 neuropeptide activity 1/6410 32/18639 0.03125 0.09086875975039 0.999998629369449 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 8/6410 73/18639 0.10958904109589 0.318663047891779 0.999999081995561 1 GO:0042923 neuropeptide binding 1/6410 33/18639 0.0303030303030303 0.0881151609700752 0.999999101543461 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/6410 53/18639 0.0754716981132075 0.219456627321697 0.999999266984557 1 GO:0098960 postsynaptic neurotransmitter receptor activity 7/6410 69/18639 0.101449275362319 0.294994234551991 0.999999320131976 1 GO:0004497 monooxygenase activity 15/6410 106/18639 0.141509433962264 0.411481176228181 0.999999352964333 1 GO:0019825 oxygen binding 1/6410 34/18639 0.0294117647058824 0.0855235385886024 0.99999941107299 1 GO:0008188 neuropeptide receptor activity 3/6410 48/18639 0.0625 0.18173751950078 0.999999462689715 1 GO:0061135 endopeptidase regulator activity 33/6410 184/18639 0.179347826086957 0.521507664654412 0.999999791845637 1 GO:0022834 ligand-gated channel activity 34/6410 188/18639 0.180851063829787 0.525878779832044 0.999999796141631 1 GO:0022824 transmitter-gated monoatomic ion channel activity 5/6410 63/18639 0.0793650793650794 0.230777802540673 0.999999854532228 1 GO:0022835 transmitter-gated channel activity 5/6410 63/18639 0.0793650793650794 0.230777802540673 0.999999854532228 1 GO:0015276 ligand-gated monoatomic ion channel activity 33/6410 186/18639 0.17741935483871 0.515900055357053 0.999999870847686 1 GO:0140375 immune receptor activity 25/6410 156/18639 0.16025641025641 0.46599363974559 0.99999992442881 1 GO:0003730 mRNA 3'-UTR binding 52/6410 262/18639 0.198473282442748 0.577120672613164 0.999999937468517 1 GO:0004866 endopeptidase inhibitor activity 26/6410 161/18639 0.161490683229814 0.469582659082761 0.999999940143688 1 GO:0015079 potassium ion transmembrane transporter activity 25/6410 160/18639 0.15625 0.45434379875195 0.999999973636994 1 GO:0030414 peptidase inhibitor activity 27/6410 169/18639 0.159763313609467 0.464559813161757 0.999999978272564 1 GO:0048020 CCR chemokine receptor binding 2/6410 50/18639 0.04 0.116312012480499 0.999999981387634 1 GO:0008083 growth factor activity 24/6410 162/18639 0.148148148148148 0.430785231409256 0.999999995054752 1 GO:0030594 neurotransmitter receptor activity 9/6410 97/18639 0.0927835051546392 0.269795905238271 0.999999998389846 1 GO:0022832 voltage-gated channel activity 24/6410 175/18639 0.137142857142857 0.398784042790283 0.99999999987136 1 GO:0005216 monoatomic ion channel activity 94/6410 448/18639 0.209821428571429 0.610118815466904 0.999999999888593 1 GO:0005244 voltage-gated monoatomic ion channel activity 23/6410 173/18639 0.132947976878613 0.386586168649058 0.99999999993565 1 GO:0042379 chemokine receptor binding 3/6410 72/18639 0.0416666666666667 0.121158346333853 0.999999999953757 1 GO:0005261 monoatomic cation channel activity 64/6410 341/18639 0.187683284457478 0.545745513104982 0.999999999959411 1 GO:0005267 potassium channel activity 12/6410 124/18639 0.0967741935483871 0.281400030194756 0.999999999969739 1 GO:0005249 voltage-gated potassium channel activity 6/6410 98/18639 0.0612244897959184 0.178028590531376 0.999999999996873 1 GO:0008528 G protein-coupled peptide receptor activity 10/6410 122/18639 0.0819672131147541 0.238344287869875 0.999999999998243 1 GO:0001653 peptide receptor activity 11/6410 128/18639 0.0859375 0.249889089313573 0.99999999999863 1 GO:0022836 gated channel activity 53/6410 318/18639 0.166666666666667 0.484633385335413 0.999999999999657 1 GO:0022843 voltage-gated monoatomic cation channel activity 13/6410 143/18639 0.0909090909090909 0.264345482910226 0.99999999999972 1 GO:0005179 hormone activity 10/6410 132/18639 0.0757575757575758 0.220287902425188 0.999999999999948 1 GO:0003735 structural constituent of ribosome 5/6410 175/18639 0.0285714285714286 0.0830800089146423 1 1 GO:0003823 antigen binding 10/6410 174/18639 0.0574712643678161 0.167114960460487 1 1 GO:0005125 cytokine activity 18/6410 234/18639 0.0769230769230769 0.223676947077883 1 1 GO:0030371 translation repressor activity 15/6410 329/18639 0.0455927051671733 0.132574482310599 1 1 GO:0045182 translation regulator activity 22/6410 356/18639 0.0617977528089888 0.179695524899648 1 1