ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	34/451	332/18367	2.02738719237748e-12	1.29144564154445e-09	LIMA1/CTNNB1/EFHD2/EPN2/ANXA1/LDHA/TES/CLINT1/TMOD3/PKP3/GOLGA2/SNX2/SHTN1/NDRG1/YWHAZ/PPFIBP1/EIF4H/PKP2/TAGLN2/PAK2/CHMP5/HSP90AB1/MPRIP/CBL/TJP1/CALD1/SERBP1/BZW2/MACF1/RDX/CTNNA1/BZW1/FMNL2/RPL29	34
GO:0140297	DNA-binding transcription factor binding	28/451	394/18367	5.3908203667106e-07	0.000171697628679733	FOS/KLF4/JUND/CEBPB/MED4/CTNNB1/TAF7/SRI/PTMA/SMARCB1/ANXA4/JUN/ZMYND8/TRIM24/CPNE1/RXRA/YWHAZ/TMF1/CTBP2/ETS2/KLF5/CALR/PPARG/FHL2/ATF4/NRIP1/TCF7L2/DNAJA1	28
GO:0042605	peptide antigen binding	8/451	36/18367	2.05452552998779e-06	0.00043624425420074	HLA-B/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-C/HLA-A/HLA-DPB1/SLC7A5	8
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	22/451	299/18367	5.14407039335167e-06	0.000819193210141253	FOS/KLF4/JUND/CEBPB/MED4/CTNNB1/TAF7/SMARCB1/ANXA4/JUN/TRIM24/CPNE1/RXRA/TMF1/CTBP2/ETS2/CALR/PPARG/ATF4/NRIP1/TCF7L2/DNAJA1	22
GO:0003712	transcription coregulator activity	29/451	489/18367	1.21603721378773e-05	0.00115943690253094	PAGE4/HDGF/MED4/CTNNB1/PAWR/MAML2/RYBP/SMARCB1/CEBPZ/HTATIP2/ZMYND8/TRIM24/CENPJ/TMF1/BASP1/ARID3A/CTBP2/CDYL/PARP14/KMT2C/FHL2/WWTR1/BRD7/RSF1/SRSF2/NRIP1/MED13L/CAMTA1/CIR1	29
GO:0005154	epidermal growth factor receptor binding	7/451	33/18367	1.26245914528704e-05	0.00115943690253094	FAM83B/VAV2/SNX2/EFEMP1/CBL/PLSCR1/GRB2	7
GO:0016922	nuclear receptor binding	14/451	144/18367	1.27410648629773e-05	0.00115943690253094	JUND/CEBPB/MED4/CTNNB1/TAF7/TRIM24/RXRA/TMF1/CTBP2/ETS2/CALR/PPARG/NRIP1/TCF7L2	14
GO:0023026	MHC class II protein complex binding	6/451	27/18367	4.04871078433137e-05	0.00322378596202385	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HSP90AB1/HLA-DPB1	6
GO:0031720	haptoglobin binding	4/451	10/18367	6.69851260443354e-05	0.00474105836558241	HBA2/HBA1/HBG2/HBB	4
GO:0042277	peptide binding	20/451	321/18367	0.000141723406676176	0.00902778100527243	APOE/CD74/CLTB/HLA-B/HLA-DRA/HLA-DRB1/NUP58/RXRA/HSPG2/HLA-DPA1/HLA-C/HLA-A/HSP90AB1/HLA-DPB1/C1QA/CST3/CALR/SLC7A5/PPARG/SLC40A1	20
GO:0070412	R-SMAD binding	5/451	23/18367	0.000203774570905806	0.0108663483200258	FOS/JUN/PMEPA1/PPARG/RGCC	5
GO:0023023	MHC protein complex binding	6/451	36/18367	0.000220986290965789	0.0108663483200258	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HSP90AB1/HLA-DPB1	6
GO:0003714	transcription corepressor activity	14/451	187/18367	0.00022176221061277	0.0108663483200258	HDGF/PAWR/RYBP/ZMYND8/BASP1/CTBP2/CDYL/PARP14/FHL2/WWTR1/BRD7/SRSF2/NRIP1/CIR1	14
GO:0005344	oxygen carrier activity	4/451	14/18367	0.000295280897346069	0.0134352808292461	HBA2/HBA1/HBG2/HBB	4
GO:0033218	amide binding	22/451	400/18367	0.000390294425056915	0.0159593035568553	APOE/CD74/CLTB/HLA-B/HLA-DRA/HLA-DRB1/NUP58/RXRA/HSPG2/HLA-DPA1/HLA-C/HLA-A/HSP90AB1/HLA-DPB1/C1QA/CST3/CALR/SLC7A5/PPARG/DBI/SLC40A1/PSAP	22
GO:0044183	protein folding chaperone	6/451	40/18367	0.000400861627801704	0.0159593035568553	CD74/HSPA2/HSP90AB1/HSPA1B/CALR/CCT6A	6
GO:0003779	actin binding	23/451	440/18367	0.000588955475537353	0.022068508112782	TPM1/TMSB4X/LIMA1/TNNI2/PAWR/TPM3/DSTN/TMOD3/GSN/FERMT2/SHTN1/MICAL3/PDLIM2/MPRIP/AIF1/CAPZA2/CALD1/MACF1/RDX/CTNNA1/GBP1/FMNL2/AFAP1	23
GO:0019207	kinase regulator activity	15/451	233/18367	0.000672033142759211	0.0236509469185381	KLF4/STK3/CCNL1/SH3BP5/GSTP1/CCNG2/PAK2/WNK1/HSP90AB1/CDC37/PIK3CA/RPLP1/DNAJC3/RGCC/CCNI	15
GO:0046332	SMAD binding	8/451	79/18367	0.000705444256596899	0.0236509469185381	FOS/SKIL/CTNNB1/JUN/PMEPA1/FERMT2/PPARG/RGCC	8
GO:0070577	lysine-acetylated histone binding	4/451	21/18367	0.00154067637273396	0.0419492819196105	BRD2/ZMYND8/TRIM24/BRD7	4
GO:0140033	acetylation-dependent protein binding	4/451	21/18367	0.00154067637273396	0.0419492819196105	BRD2/ZMYND8/TRIM24/BRD7	4
GO:0032395	MHC class II receptor activity	3/451	10/18367	0.0015518155931391	0.0419492819196105	HLA-DRA/HLA-DRB1/HLA-DPA1	3
GO:0045294	alpha-catenin binding	3/451	10/18367	0.0015518155931391	0.0419492819196105	CTNNB1/PKP3/PKP2	3
GO:0004857	enzyme inhibitor activity	7/451	70/18367	0.00162427074525367	0.0419492819196105	APOC1/ANXA1/ANXA4/RPS15/RPL23/ANGPTL4/TXNIP	7
GO:0019887	protein kinase regulator activity	13/451	204/18367	0.00164636114284186	0.0419492819196105	STK3/CCNL1/SH3BP5/CCNG2/PAK2/WNK1/HSP90AB1/CDC37/PIK3CA/RPLP1/DNAJC3/RGCC/CCNI	13
GO:0043177	organic acid binding	10/451	135/18367	0.0018524912932748	0.0444737954313279	P4HA1/HBA2/S100A9/HBA1/HBG2/S100A8/RXRA/PLOD2/PPARG/HBB	10
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	7/451	72/18367	0.00191419216659819	0.0444737954313279	UQCR10/NDUFB2/NDUFA3/COX6A1/NDUFB1/NDUFA4/COX4I1	7
GO:0033293	monocarboxylic acid binding	7/451	73/18367	0.00207340807034252	0.0444737954313279	APOC1/S100A9/S100A8/GSTP1/RXRA/PPARG/PSAP	7
GO:0042608	T cell receptor binding	3/451	11/18367	0.00209503811387779	0.0444737954313279	HLA-DRA/HLA-DRB1/HLA-A	3
GO:1990226	histone methyltransferase binding	3/451	11/18367	0.00209503811387779	0.0444737954313279	CTNNB1/CBX3/HSP90AB1	3
GO:0003713	transcription coactivator activity	15/451	262/18367	0.00216434483260779	0.0444737954313279	PAGE4/MED4/CTNNB1/MAML2/SMARCB1/CEBPZ/HTATIP2/TRIM24/CENPJ/TMF1/CTBP2/KMT2C/WWTR1/BRD7/NRIP1	15
GO:0005504	fatty acid binding	5/451	39/18367	0.00252602442974305	0.0502836738045726	APOC1/S100A9/S100A8/GSTP1/PPARG	5
GO:0005543	phospholipid binding	22/451	466/18367	0.00277692453892316	0.0530289767623954	APOE/APOC1/ING2/AIDA/EPN2/ANXA1/PHLDA2/MAPKAP1/CLINT1/ANXA4/CPNE1/PLEKHA5/GSN/SNX2/FERMT2/SESTD1/ZCCHC2/PXDC1/OSBPL1A/MYOF/GOLPH3/PSAP	22
GO:0051015	actin filament binding	13/451	217/18367	0.00283043204069301	0.0530289767623954	TPM1/LIMA1/TPM3/DSTN/GSN/FERMT2/SHTN1/MPRIP/AIF1/CAPZA2/MACF1/CTNNA1/FMNL2	13
GO:0001221	transcription coregulator binding	7/451	78/18367	0.00302862173962223	0.0551209156611245	KLF4/HDGF/CTNNB1/CBX3/RPL23/THRB/CTBP2	7
GO:0004859	phospholipase inhibitor activity	3/451	13/18367	0.00350108234058572	0.0619497069709195	APOC1/ANXA1/ANXA4	3
GO:0140678	molecular function inhibitor activity	9/451	128/18367	0.00435828541096957	0.0714647331433919	APOC1/ANXA1/ANXA4/RPS15/RPL23/TAF3/WNK1/ANGPTL4/TXNIP	9
GO:0035259	glucocorticoid receptor binding	3/451	14/18367	0.00437539182510563	0.0714647331433919	CEBPB/ETS2/NRIP1	3
GO:0036041	long-chain fatty acid binding	3/451	14/18367	0.00437539182510563	0.0714647331433919	S100A9/S100A8/PPARG	3
GO:0001968	fibronectin binding	4/451	28/18367	0.00460334134612853	0.0733082109370968	IGFBP3/PLEKHA2/CCDC80/CTSS	4
GO:0051087	chaperone binding	8/451	107/18367	0.00487142151370028	0.0756852562006605	HLA-B/HSPA2/LRP2/DNAJC1/CDC37/CALR/DNAJC3/DNAJA1	8
GO:0016209	antioxidant activity	7/451	86/18367	0.00521448353734607	0.0790863336497488	APOE/HBA2/S100A9/HBA1/HBG2/GSTP1/HBB	7
GO:0042809	vitamin D receptor binding	3/451	15/18367	0.00537052049836797	0.079558640871172	MED4/TAF7/RXRA	3
GO:0003727	single-stranded RNA binding	7/451	87/18367	0.00555410744855555	0.0804083282893156	ANXA1/HNRNPF/EIF4H/EIF4A3/HNRNPA1/KHDRBS1/LSM14A	7
GO:0098632	cell-cell adhesion mediator activity	5/451	49/18367	0.00685121071604235	0.0969826939137551	ANXA1/TMOD3/PKP3/PKP2/DSP	5
GO:0008017	microtubule binding	14/451	271/18367	0.00734556932392635	0.101720166507415	CCSAP/S100A9/GABARAP/S100A8/KIF2A/GOLGA2/SBDS/KATNBL1/NDRG1/MTUS1/MX1/MAP4/MACF1/MAP7D3	14
GO:0042393	histone binding	13/451	244/18367	0.00750934021573272	0.10177552590259	TSPYL2/ING2/TAF7/MORC3/BRD2/SPTY2D1/ZMYND8/TRIM24/CDYL/PHF14/KMT2C/BRD7/RSF1	13
GO:0043024	ribosomal small subunit binding	3/451	17/18367	0.00773968549372705	0.102712076239669	PIM1/EIF1B/EIF4H	3
GO:0004601	peroxidase activity	5/451	51/18367	0.00811066652838148	0.105438664868959	HBA2/HBA1/HBG2/GSTP1/HBB	5
GO:0055102	lipase inhibitor activity	3/451	18/18367	0.00912062605295526	0.113918407759461	APOC1/ANXA1/ANXA4	3
GO:0098641	cadherin binding involved in cell-cell adhesion	3/451	18/18367	0.00912062605295526	0.113918407759461	ANXA1/TMOD3/PKP3	3
GO:0019003	GDP binding	6/451	75/18367	0.0102577341834198	0.125657243746892	RAP1B/RHOB/RRAS2/RAB8B/GBP1/RHOA	6
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/451	55/18367	0.0110942493252029	0.133340317361401	HBA2/HBA1/HBG2/GSTP1/HBB	5
GO:0097718	disordered domain specific binding	4/451	36/18367	0.011356754941762	0.133967646257451	DFFB/CTNNB1/HSPA2/HSP90AB1	4
GO:0045309	protein phosphorylated amino acid binding	5/451	56/18367	0.0119428692111068	0.138320139772274	VAV2/SH2D3A/CBL/GRB2/RTF1	5
GO:0009055	electron transfer activity	8/451	126/18367	0.0125946783859801	0.143264466640523	UQCR10/FDX1/NDUFB2/NDUFA3/COX6A1/NDUFB1/NDUFA4/COX4I1	8
GO:0003735	structural constituent of ribosome	10/451	182/18367	0.0146679755026491	0.15904871265478	RPL39/RPS15/RPL23/RPS12/RPS19/RPL28/RPS28/RPS11/RPLP1/RPL29	10
GO:0098631	cell adhesion mediator activity	5/451	59/18367	0.0147504794164452	0.15904871265478	ANXA1/TMOD3/PKP3/PKP2/DSP	5
GO:0019825	oxygen binding	4/451	39/18367	0.0149740857381423	0.15904871265478	HBA2/HBA1/HBG2/HBB	4
GO:0017124	SH3 domain binding	8/451	130/18367	0.0149810404384408	0.15904871265478	SH3BP5/LRP2/CBL/KHDRBS1/PLSCR1/GRB2/ZNF106/AFAP1	8
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	19/451	450/18367	0.0159437297252058	0.1664943579501	FOS/OSR2/KLF4/JUND/CEBPB/LITAF/JUN/FOSB/SOX4/KLF6/GRHL1/FOXJ3/ZNF292/VEZF1/IRF1/PLSCR1/KLF5/ATF4/GATA3	19
GO:0140030	modification-dependent protein binding	9/451	160/18367	0.0174720251388182	0.179510967958503	ING2/TAF7/MORC3/BRD2/ZMYND8/TRIM24/CDYL/BRD7/LAPTM5	9
GO:0001216	DNA-binding transcription activator activity	19/451	456/18367	0.0180489300180524	0.179998342578951	FOS/OSR2/KLF4/JUND/CEBPB/LITAF/JUN/FOSB/SOX4/KLF6/GRHL1/FOXJ3/ZNF292/VEZF1/IRF1/PLSCR1/KLF5/ATF4/GATA3	19
GO:0050750	low-density lipoprotein particle receptor binding	3/451	23/18367	0.0180846058478067	0.179998342578951	APOE/HSPG2/DNAJA1	3
GO:0008137	NADH dehydrogenase (ubiquinone) activity	4/451	42/18367	0.0192448037547859	0.188599076796901	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0050136	NADH dehydrogenase (quinone) activity	4/451	43/18367	0.0208188075431338	0.195966622917741	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0019888	protein phosphatase regulator activity	6/451	89/18367	0.0222983412066117	0.195966622917741	IGFBP3/ANKLE2/PPP1R15A/PPP1R14B/PPP2R2D/EIF2AK2	6
GO:0001784	phosphotyrosine residue binding	4/451	44/18367	0.0224695852474352	0.195966622917741	VAV2/SH2D3A/CBL/GRB2	4
GO:0070851	growth factor receptor binding	8/451	141/18367	0.0232142347664144	0.195966622917741	FAM83B/VAV2/SNX2/EFEMP1/CBL/PLSCR1/GRB2/GATA3	8
GO:0015631	tubulin binding	16/451	375/18367	0.0235251161602189	0.195966622917741	CCSAP/S100A9/GABARAP/S100A8/KIF2A/CENPJ/GOLGA2/SBDS/KATNBL1/NDRG1/MTUS1/BEX4/MX1/MAP4/MACF1/MAP7D3	16
GO:0004955	prostaglandin receptor activity	2/451	10/18367	0.0237610267583954	0.195966622917741	HPGD/PPARG	2
GO:0015173	aromatic amino acid transmembrane transporter activity	2/451	10/18367	0.0237610267583954	0.195966622917741	SLC7A1/SLC7A5	2
GO:0019869	chloride channel inhibitor activity	2/451	10/18367	0.0237610267583954	0.195966622917741	WNK1/VAMP8	2
GO:0030957	Tat protein binding	2/451	10/18367	0.0237610267583954	0.195966622917741	SMARCB1/DNAJA1	2
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/451	10/18367	0.0237610267583954	0.195966622917741	FAM83B/CBL	2
GO:0050786	RAGE receptor binding	2/451	10/18367	0.0237610267583954	0.195966622917741	S100A9/S100A8	2
GO:0003954	NADH dehydrogenase activity	4/451	45/18367	0.0241979331969696	0.195966622917741	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	4/451	45/18367	0.0241979331969696	0.195966622917741	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0097110	scaffold protein binding	5/451	67/18367	0.0243035529207245	0.195966622917741	KRT8/VIM/CDC37/DSP/PSAP	5
GO:0044389	ubiquitin-like protein ligase binding	14/451	316/18367	0.0248481809336581	0.197832588224086	CEBPB/GABARAP/JUN/UBE2D1/RPL23/YWHAZ/HSP90AB1/HSPA1B/TXNIP/JAK1/CALR/UBE2J1/LAPTM5/DNAJA1	14
GO:0042974	retinoic acid receptor binding	3/451	26/18367	0.0251561061948995	0.197832588224086	CTBP2/PPARG/NRIP1	3
GO:0061980	regulatory RNA binding	4/451	46/18367	0.026004556358699	0.20201100488404	SOX4/YBX1/MBD2/HNRNPA1	4
GO:0004954	prostanoid receptor activity	2/451	11/18367	0.0285756909016215	0.209226610394631	HPGD/PPARG	2
GO:0019864	IgG binding	2/451	11/18367	0.0285756909016215	0.209226610394631	FCER1G/FCGRT	2
GO:0043522	leucine zipper domain binding	2/451	11/18367	0.0285756909016215	0.209226610394631	PAWR/ATF4	2
GO:0043560	insulin receptor substrate binding	2/451	11/18367	0.0285756909016215	0.209226610394631	GRB2/PIK3CA	2
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/451	11/18367	0.0285756909016215	0.209226610394631	PKP2/DSP	2
GO:0031406	carboxylic acid binding	9/451	176/18367	0.0300590077353814	0.212810187166054	APOC1/P4HA1/S100A9/S100A8/GSTP1/RXRA/PLOD2/PPARG/PSAP	9
GO:0070325	lipoprotein particle receptor binding	3/451	28/18367	0.0305811326967399	0.212810187166054	APOE/HSPG2/DNAJA1	3
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	3/451	28/18367	0.0305811326967399	0.212810187166054	MAPKAP1/PLEKHA5/SESTD1	3
GO:0043021	ribonucleoprotein complex binding	8/451	149/18367	0.0309143602485606	0.212810187166054	PIM1/EIF1B/SBDS/EIF4H/EIF4A3/SERBP1/RBM3/RPLP1	8
GO:0051082	unfolded protein binding	7/451	122/18367	0.0309462103717187	0.212810187166054	HSPA2/HSP90AB1/HSPA1B/CDC37/CALR/CCT6A/DNAJA1	7
GO:0031625	ubiquitin protein ligase binding	13/451	297/18367	0.032498397935221	0.212810187166054	GABARAP/JUN/UBE2D1/RPL23/YWHAZ/HSP90AB1/HSPA1B/TXNIP/JAK1/CALR/UBE2J1/LAPTM5/DNAJA1	13
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	3/451	29/18367	0.0335053463212589	0.212810187166054	PLEKHA2/MAPKAP1/SESTD1	3
GO:0051787	misfolded protein binding	3/451	29/18367	0.0335053463212589	0.212810187166054	HSPA2/HSPA1B/DNAJC3	3
GO:0070273	phosphatidylinositol-4-phosphate binding	3/451	29/18367	0.0335053463212589	0.212810187166054	PLEKHA5/SESTD1/GOLPH3	3
GO:0035064	methylated histone binding	5/451	73/18367	0.0336034977978338	0.212810187166054	ING2/TAF7/MORC3/ZMYND8/CDYL	5
GO:0140034	methylation-dependent protein binding	5/451	73/18367	0.0336034977978338	0.212810187166054	ING2/TAF7/MORC3/ZMYND8/CDYL	5
GO:0140104	molecular carrier activity	5/451	73/18367	0.0336034977978338	0.212810187166054	HBA2/NUTF2/HBA1/HBG2/HBB	5
GO:0035325	Toll-like receptor binding	2/451	12/18367	0.0337422745742094	0.212810187166054	S100A9/S100A8	2
GO:0045295	gamma-catenin binding	2/451	12/18367	0.0337422745742094	0.212810187166054	CTNNA1/TCF7L2	2
GO:0003725	double-stranded RNA binding	5/451	74/18367	0.035340642026696	0.220705774225542	VIM/EIF2AK2/EIF4H/HSP90AB1/LSM14A	5
GO:0035091	phosphatidylinositol binding	12/451	271/18367	0.0361418599794701	0.223518104921577	ING2/AIDA/PHLDA2/MAPKAP1/PLEKHA5/GSN/SNX2/FERMT2/SESTD1/ZCCHC2/PXDC1/GOLPH3	12
GO:0042826	histone deacetylase binding	7/451	127/18367	0.0372772596794708	0.228323215536758	KLF4/CEBPB/BEX4/HSP90AB1/HSPA1B/NRIP1/CIR1	7
GO:0030295	protein kinase activator activity	6/451	101/18367	0.0382158282927117	0.231842691642451	STK3/PAK2/WNK1/PIK3CA/RPLP1/RGCC	6
GO:0031994	insulin-like growth factor I binding	2/451	13/18367	0.0392406731621411	0.233610362656858	IGFBP3/LRP2	2
GO:0072542	protein phosphatase activator activity	2/451	13/18367	0.0392406731621411	0.233610362656858	IGFBP3/PPP1R15A	2
GO:0005200	structural constituent of cytoskeleton	6/451	103/18367	0.0414256659332532	0.244334714810021	KRT19/TPM1/HLA-DRB1/VIM/TUBB6/DSP	6
GO:0071837	HMG box domain binding	2/451	14/18367	0.0450515533849803	0.260889450056659	JUN/GATA3	2
GO:0140666	annealing activity	2/451	14/18367	0.0450515533849803	0.260889450056659	ANXA1/EIF4H	2
GO:0019208	phosphatase regulator activity	6/451	107/18367	0.0483425623663988	0.270826333447351	IGFBP3/ANKLE2/PPP1R15A/PPP1R14B/PPP2R2D/EIF2AK2	6
GO:0019209	kinase activator activity	6/451	107/18367	0.0483425623663988	0.270826333447351	STK3/PAK2/WNK1/PIK3CA/RPLP1/RGCC	6
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/451	56/18367	0.0484681350282543	0.270826333447351	TNFAIP8/CST6/BIRC7/CST3	4
GO:0050840	extracellular matrix binding	4/451	56/18367	0.0484681350282543	0.270826333447351	PLEKHA2/SPP1/CTSS/SPARC	4
GO:0035198	miRNA binding	3/451	34/18367	0.0501971736490771	0.271560878760927	SOX4/YBX1/HNRNPA1	3
GO:0043548	phosphatidylinositol 3-kinase binding	3/451	34/18367	0.0501971736490771	0.271560878760927	FAM83B/GSN/CBL	3
GO:0004953	icosanoid receptor activity	2/451	15/18367	0.0511563276752283	0.271560878760927	HPGD/PPARG	2
GO:0019215	intermediate filament binding	2/451	15/18367	0.0511563276752283	0.271560878760927	VIM/PKP2	2
GO:0070742	C2H2 zinc finger domain binding	2/451	15/18367	0.0511563276752283	0.271560878760927	MBD2/SRRM2	2
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4/451	57/18367	0.0511574653866738	0.271560878760927	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0001540	amyloid-beta binding	5/451	84/18367	0.0557466816723704	0.29225928652788	APOE/CD74/HSPG2/C1QA/CST3	5
GO:0051020	GTPase binding	12/451	291/18367	0.0563781416275867	0.29225928652788	NUTF2/MAPKAP1/BNIP3/NDRG1/GOLGA4/MICAL3/PAK2/YBX1/GNB1/CHML/FMNL2/RAB11FIP1	12
GO:0045182	translation regulator activity	7/451	140/18367	0.0575342338323535	0.29225928652788	EIF2AK2/EIF1B/ABCF1/EIF4H/EIF2AK4/EIF4A3/DENR	7
GO:0005523	tropomyosin binding	2/451	16/18367	0.0575371293464151	0.29225928652788	TMOD3/CALD1	2
GO:0042162	telomeric DNA binding	3/451	36/18367	0.0578095292033169	0.29225928652788	NCL/SMG1/HNRNPA1	3
GO:0042805	actinin binding	3/451	36/18367	0.0578095292033169	0.29225928652788	CSRP1/PDLIM2/PPARG	3
GO:0003823	antigen binding	8/451	171/18367	0.0605972410831632	0.303940492676968	HLA-B/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-C/HLA-A/HLA-DPB1/SLC7A5	8
GO:0046915	transition metal ion transmembrane transporter activity	3/451	37/18367	0.0618081315169133	0.307592029502139	SLC25A37/TMEM165/SLC40A1	3
GO:0017081	chloride channel regulator activity	2/451	17/18367	0.0641767885267735	0.312065757950799	WNK1/VAMP8	2
GO:0030275	LRR domain binding	2/451	17/18367	0.0641767885267735	0.312065757950799	PAWR/ATF4	2
GO:0046965	retinoid X receptor binding	2/451	17/18367	0.0641767885267735	0.312065757950799	PPARG/NRIP1	2
GO:0048306	calcium-dependent protein binding	5/451	88/18367	0.0654696013804054	0.313564932927205	S100A9/ANXA1/S100A8/ANXA4/PDCD6	5
GO:0051219	phosphoprotein binding	5/451	88/18367	0.0654696013804054	0.313564932927205	VAV2/SH2D3A/CBL/GRB2/RTF1	5
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/451	39/18367	0.0701783973094433	0.333609246911309	UBE2D1/UBE2J1/UFC1	3
GO:0050811	GABA receptor binding	2/451	18/18367	0.0710588088360007	0.335292305396537	GABARAP/PLCL2	2
GO:0031492	nucleosomal DNA binding	3/451	40/18367	0.0745450129627705	0.34915568571533	SMARCB1/HMGN1/MBD2	3
GO:0004129	cytochrome-c oxidase activity	2/451	19/18367	0.0781673447832491	0.360065833524065	COX6A1/COX4I1	2
GO:0010314	phosphatidylinositol-5-phosphate binding	2/451	19/18367	0.0781673447832491	0.360065833524065	PLEKHA5/SESTD1	2
GO:0002039	p53 binding	4/451	66/18367	0.0789109307773903	0.360065833524065	SMARCB1/TRIM24/TAF3/BRD7	4
GO:0005506	iron ion binding	7/451	151/18367	0.0791353480272671	0.360065833524065	FTL/P4HA1/HBA2/HBA1/FDX1/PLOD2/CALR	7
GO:0001046	core promoter sequence-specific DNA binding	3/451	42/18367	0.0836278828205816	0.363035557160507	FOS/CEBPB/SMARCB1	3
GO:0008307	structural constituent of muscle	3/451	42/18367	0.0836278828205816	0.363035557160507	KRT19/TPM1/CSRP1	3
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/451	20/18367	0.0854871798651115	0.363035557160507	FOS/CEBPB	2
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/451	20/18367	0.0854871798651115	0.363035557160507	ZNHIT6/TAF7	2
GO:0003756	protein disulfide isomerase activity	2/451	20/18367	0.0854871798651115	0.363035557160507	ERO1A/ERP44	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/451	20/18367	0.0854871798651115	0.363035557160507	COX6A1/COX4I1	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/451	20/18367	0.0854871798651115	0.363035557160507	ERO1A/ERP44	2
GO:0019211	phosphatase activator activity	2/451	20/18367	0.0854871798651115	0.363035557160507	IGFBP3/PPP1R15A	2
GO:0031418	L-ascorbic acid binding	2/451	20/18367	0.0854871798651115	0.363035557160507	P4HA1/PLOD2	2
GO:0070300	phosphatidic acid binding	2/451	20/18367	0.0854871798651115	0.363035557160507	MAPKAP1/SESTD1	2
GO:0004674	protein serine/threonine kinase activity	14/451	386/18367	0.0955582255078815	0.403116487738547	STK3/PNCK/PIM1/BRD2/CLK4/EIF2AK2/HTATIP2/RIOK3/SMG1/PAK2/EIF2AK4/WNK1/MAPK6/PLK2	14
GO:0004715	non-membrane spanning protein tyrosine kinase activity	3/451	45/18367	0.0980839813425211	0.407268138427909	EIF2AK2/JAK1/WEE1	3
GO:0048156	tau protein binding	3/451	45/18367	0.0980839813425211	0.407268138427909	APOE/HSPA2/HSP90AB1	3
GO:0031072	heat shock protein binding	6/451	129/18367	0.0984604290704834	0.407268138427909	HSPA2/HSP90AB1/HSPA1B/CDC37/GBP1/DNAJA1	6
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/451	22/18367	0.100702899679672	0.408988760710573	TNFAIP8/BIRC7	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/451	22/18367	0.100702899679672	0.408988760710573	RPS15/RPL23	2
GO:0030276	clathrin binding	4/451	72/18367	0.100802567396483	0.408988760710573	CLTB/EPN2/CLINT1/AFTPH	4
GO:0106310	protein serine kinase activity	13/451	360/18367	0.108012693379312	0.431485592783822	STK3/PNCK/PIM1/CLK4/EIF2AK2/RIOK3/SMG1/PAK2/EIF2AK4/WNK1/MAPK6/PLK2/PIK3CA	13
GO:0008143	poly(A) binding	2/451	23/18367	0.10857130861604	0.431485592783822	EIF4A3/KHDRBS1	2
GO:0019865	immunoglobulin binding	2/451	23/18367	0.10857130861604	0.431485592783822	FCER1G/FCGRT	2
GO:0031490	chromatin DNA binding	5/451	103/18367	0.109680804296381	0.431485592783822	SMARCB1/THRB/GRHL1/HMGN1/MBD2	5
GO:0044325	transmembrane transporter binding	6/451	133/18367	0.109734169593374	0.431485592783822	CTNNB1/SRI/GOPC/YWHAZ/PKP2/HSP90AB1	6
GO:0008201	heparin binding	7/451	166/18367	0.115203953372429	0.450214222688574	APOE/HDGF/SFRP1/ADAMTS1/NAV2/CCDC80/RPL29	7
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/451	50/18367	0.124197354115322	0.478765648257887	CCNL1/CCNG2/CCNI	3
GO:0030247	polysaccharide binding	2/451	25/18367	0.124764674428272	0.478765648257887	HLA-DRA/HLA-DRB1	2
GO:0035035	histone acetyltransferase binding	2/451	25/18367	0.124764674428272	0.478765648257887	CEBPB/TAF7	2
GO:0003743	translation initiation factor activity	3/451	51/18367	0.129695300079475	0.494706024854047	EIF1B/EIF4H/DENR	3
GO:1901981	phosphatidylinositol phosphate binding	7/451	173/18367	0.134543233749169	0.506893447693455	PHLDA2/MAPKAP1/PLEKHA5/GSN/FERMT2/SESTD1/GOLPH3	7
GO:0004879	nuclear receptor activity	3/451	52/18367	0.135277686197625	0.506893447693455	RXRA/THRB/PPARG	3
GO:0098531	ligand-activated transcription factor activity	3/451	52/18367	0.135277686197625	0.506893447693455	RXRA/THRB/PPARG	3
GO:0001671	ATPase activator activity	2/451	27/18367	0.141486795690803	0.515011936314524	DNAJC1/DNAJA1	2
GO:0030507	spectrin binding	2/451	27/18367	0.141486795690803	0.515011936314524	GNB1/GBP1	2
GO:0043425	bHLH transcription factor binding	2/451	27/18367	0.141486795690803	0.515011936314524	KLF5/FHL2	2
GO:0048027	mRNA 5'-UTR binding	2/451	27/18367	0.141486795690803	0.515011936314524	GNL3/NCL	2
GO:0051393	alpha-actinin binding	2/451	27/18367	0.141486795690803	0.515011936314524	PDLIM2/PPARG	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	11/451	310/18367	0.143070747288583	0.516548466712167	SKIL/CEBPB/MXI1/JUN/ZNF217/NFIL3/IRX2/ETS2/PPARG/GATA3/NFE2L3	11
GO:0140375	immune receptor activity	6/451	144/18367	0.143921181891353	0.516548466712167	CD74/HLA-DRA/HLA-DRB1/IFNAR1/FCER1G/HLA-DPA1	6
GO:0005544	calcium-dependent phospholipid binding	3/451	54/18367	0.146683151748259	0.516548466712167	ANXA1/ANXA4/CPNE1	3
GO:0001217	DNA-binding transcription repressor activity	11/451	313/18367	0.149719585089819	0.516548466712167	SKIL/CEBPB/MXI1/JUN/ZNF217/NFIL3/IRX2/ETS2/PPARG/GATA3/NFE2L3	11
GO:0003785	actin monomer binding	2/451	28/18367	0.150018000536501	0.516548466712167	TMSB4X/LIMA1	2
GO:0017056	structural constituent of nuclear pore	2/451	28/18367	0.150018000536501	0.516548466712167	NUTF2/NUP58	2
GO:0043236	laminin binding	2/451	28/18367	0.150018000536501	0.516548466712167	PLEKHA2/CTSS	2
GO:0046875	ephrin receptor binding	2/451	28/18367	0.150018000536501	0.516548466712167	CBL/GRB2	2
GO:0050681	androgen receptor binding	2/451	28/18367	0.150018000536501	0.516548466712167	TMF1/CALR	2
GO:0051861	glycolipid binding	2/451	28/18367	0.150018000536501	0.516548466712167	HSPA2/PSAP	2
GO:0008135	translation factor activity, RNA binding	4/451	84/18367	0.151746598459441	0.519478333427119	EIF1B/ABCF1/EIF4H/DENR	4
GO:0005080	protein kinase C binding	3/451	55/18367	0.152499918918165	0.519478333427119	PKP2/DSP/SRSF2	3
GO:0008013	beta-catenin binding	4/451	85/18367	0.15637142909767	0.523622474131163	KLF4/CTNNB1/CTNNA1/TCF7L2	4
GO:0051287	NAD binding	3/451	56/18367	0.158388510459103	0.523622474131163	LDHA/CTBP2/HPGD	3
GO:0015399	primary active transmembrane transporter activity	7/451	181/18367	0.158461955439465	0.523622474131163	UQCR10/NDUFB2/NDUFA3/COX6A1/NDUFB1/NDUFA4/COX4I1	7
GO:0005520	insulin-like growth factor binding	2/451	29/18367	0.158648567515407	0.523622474131163	IGFBP3/LRP2	2
GO:0051059	NF-kappaB binding	2/451	29/18367	0.158648567515407	0.523622474131163	ANXA4/CPNE1	2
GO:0070717	poly-purine tract binding	2/451	29/18367	0.158648567515407	0.523622474131163	EIF4A3/KHDRBS1	2
GO:0042562	hormone binding	4/451	86/18367	0.16104824544294	0.52880274405749	THRB/LRP2/CALR/SLC40A1	4
GO:0046966	thyroid hormone receptor binding	2/451	30/18367	0.167368505364768	0.546737117524909	MED4/TAF7	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	4/451	88/18367	0.170552091089148	0.554294296039731	NDUFB2/NDUFA3/NDUFB1/NDUFA4	4
GO:0008081	phosphoric diester hydrolase activity	4/451	89/18367	0.175376221528737	0.563915458595453	HMOX1/GDPD3/GNB1/PLCL2	4
GO:0043015	gamma-tubulin binding	2/451	31/18367	0.176168251586335	0.563915458595453	CENPJ/NDRG1	2
GO:0140318	protein transporter activity	2/451	31/18367	0.176168251586335	0.563915458595453	LRP2/MCL1	2
GO:0001222	transcription corepressor binding	2/451	32/18367	0.185038657492057	0.583512994170498	HDGF/CTBP2	2
GO:0001223	transcription coactivator binding	2/451	32/18367	0.185038657492057	0.583512994170498	RPL23/THRB	2
GO:0050699	WW domain binding	2/451	32/18367	0.185038657492057	0.583512994170498	LITAF/PMEPA1	2
GO:0031267	small GTPase binding	9/451	259/18367	0.188310853761042	0.589475063938879	NUTF2/MAPKAP1/NDRG1/GOLGA4/MICAL3/PAK2/CHML/FMNL2/RAB11FIP1	9
GO:0015179	L-amino acid transmembrane transporter activity	3/451	61/18367	0.1887996871633	0.589475063938879	SLC7A1/SLC1A6/SLC7A5	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	5/451	124/18367	0.189705475835903	0.589475063938879	CLK4/EIF2AK2/EFEMP1/JAK1/WEE1	5
GO:0051427	hormone receptor binding	2/451	33/18367	0.193970973723049	0.599803447871758	JAK1/CSH1	2
GO:1901681	sulfur compound binding	9/451	265/18367	0.205714163266946	0.624928107989884	APOE/HDGF/SFRP1/GSTP1/ADAMTS1/NAV2/CCDC80/DBI/RPL29	9
GO:0001094	TFIID-class transcription factor complex binding	1/451	10/18367	0.220167226041066	0.624928107989884	ZNHIT6	1
GO:0005384	manganese ion transmembrane transporter activity	1/451	10/18367	0.220167226041066	0.624928107989884	TMEM165	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/451	10/18367	0.220167226041066	0.624928107989884	DUSP4	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/451	10/18367	0.220167226041066	0.624928107989884	UBA6	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/451	10/18367	0.220167226041066	0.624928107989884	MAN1A1	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/451	10/18367	0.220167226041066	0.624928107989884	PIK3CA	1
GO:0034713	type I transforming growth factor beta receptor binding	1/451	10/18367	0.220167226041066	0.624928107989884	FERMT2	1
GO:0043208	glycosphingolipid binding	1/451	10/18367	0.220167226041066	0.624928107989884	PSAP	1
GO:0047844	deoxycytidine deaminase activity	1/451	10/18367	0.220167226041066	0.624928107989884	CDA	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/451	10/18367	0.220167226041066	0.624928107989884	PIK3CA	1
GO:0070008	serine-type exopeptidase activity	1/451	10/18367	0.220167226041066	0.624928107989884	CPVL	1
GO:0070016	armadillo repeat domain binding	1/451	10/18367	0.220167226041066	0.624928107989884	TCF7L2	1
GO:0098505	G-rich strand telomeric DNA binding	1/451	10/18367	0.220167226041066	0.624928107989884	HNRNPA1	1
GO:0015248	sterol transporter activity	2/451	36/18367	0.221057589360409	0.624928107989884	APOE/OSBPL1A	2
GO:0043394	proteoglycan binding	2/451	36/18367	0.221057589360409	0.624928107989884	APOE/CTSS	2
GO:0061631	ubiquitin conjugating enzyme activity	2/451	36/18367	0.221057589360409	0.624928107989884	UBE2D1/UBE2J1	2
GO:0005109	frizzled binding	2/451	37/18367	0.230157558380037	0.624928107989884	WNT7A/SFRP1	2
GO:0071949	FAD binding	2/451	37/18367	0.230157558380037	0.624928107989884	ERO1A/MICAL3	2
GO:0019843	rRNA binding	3/451	68/18367	0.233533941145726	0.624928107989884	RPL23/SBDS/RPS11	3
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/451	38/18367	0.239281205412042	0.624928107989884	TAF7/TAF3	2
GO:0005347	ATP transmembrane transporter activity	1/451	11/18367	0.239326379555011	0.624928107989884	SLC25A24	1
GO:0005536	glucose binding	1/451	11/18367	0.239326379555011	0.624928107989884	SLC2A3	1
GO:0008199	ferric iron binding	1/451	11/18367	0.239326379555011	0.624928107989884	FTL	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/451	11/18367	0.239326379555011	0.624928107989884	ERO1A	1
GO:0017128	phospholipid scramblase activity	1/451	11/18367	0.239326379555011	0.624928107989884	PLSCR1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/451	11/18367	0.239326379555011	0.624928107989884	HSD17B1	1
GO:0035197	siRNA binding	1/451	11/18367	0.239326379555011	0.624928107989884	MBD2	1
GO:0051400	BH domain binding	1/451	11/18367	0.239326379555011	0.624928107989884	MCL1	1
GO:0070513	death domain binding	1/451	11/18367	0.239326379555011	0.624928107989884	MCL1	1
GO:0097371	MDM2/MDM4 family protein binding	1/451	11/18367	0.239326379555011	0.624928107989884	RPS15	1
GO:0097493	structural molecule activity conferring elasticity	1/451	11/18367	0.239326379555011	0.624928107989884	FBN2	1
GO:0140036	ubiquitin-dependent protein binding	1/451	11/18367	0.239326379555011	0.624928107989884	LAPTM5	1
GO:1901474	azole transmembrane transporter activity	1/451	11/18367	0.239326379555011	0.624928107989884	SLC7A1	1
GO:1990459	transferrin receptor binding	1/451	11/18367	0.239326379555011	0.624928107989884	SNX2	1
GO:0005518	collagen binding	3/451	69/18367	0.240079438341526	0.624928107989884	MRC2/CTSS/SPARC	3
GO:0004713	protein tyrosine kinase activity	5/451	136/18367	0.242630016089053	0.624928107989884	CLK4/EIF2AK2/EFEMP1/JAK1/WEE1	5
GO:0001098	basal transcription machinery binding	3/451	70/18367	0.246655282713398	0.624928107989884	ZNHIT6/TAF7/RTF1	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/451	70/18367	0.246655282713398	0.624928107989884	ZNHIT6/TAF7/RTF1	3
GO:0004860	protein kinase inhibitor activity	3/451	70/18367	0.246655282713398	0.624928107989884	SH3BP5/WNK1/DNAJC3	3
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/451	39/18367	0.248421897741912	0.624928107989884	MAPKAP1/FERMT2	2
GO:0031491	nucleosome binding	3/451	71/18367	0.253258789904829	0.624928107989884	SMARCB1/HMGN1/MBD2	3
GO:0048029	monosaccharide binding	3/451	71/18367	0.253258789904829	0.624928107989884	P4HA1/SLC2A3/PLOD2	3
GO:0020037	heme binding	5/451	139/18367	0.256445133492714	0.624928107989884	HBA2/HBA1/HBG2/HMOX1/HBB	5
GO:0003925	G protein activity	2/451	40/18367	0.257573312730287	0.624928107989884	RAP1B/RHOA	2
GO:0042169	SH2 domain binding	2/451	40/18367	0.257573312730287	0.624928107989884	KHDRBS1/AFAP1	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/451	40/18367	0.257573312730287	0.624928107989884	TNFAIP8/BIRC7	2
GO:0004126	cytidine deaminase activity	1/451	12/18367	0.258015843644175	0.624928107989884	CDA	1
GO:0005165	neurotrophin receptor binding	1/451	12/18367	0.258015843644175	0.624928107989884	GRB2	1
GO:0017166	vinculin binding	1/451	12/18367	0.258015843644175	0.624928107989884	CTNNA1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/451	12/18367	0.258015843644175	0.624928107989884	P4HA1	1
GO:0033130	acetylcholine receptor binding	1/451	12/18367	0.258015843644175	0.624928107989884	UBXN2A	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/451	12/18367	0.258015843644175	0.624928107989884	PIK3CA	1
GO:0043047	single-stranded telomeric DNA binding	1/451	12/18367	0.258015843644175	0.624928107989884	HNRNPA1	1
GO:0043422	protein kinase B binding	1/451	12/18367	0.258015843644175	0.624928107989884	SRSF5	1
GO:0089720	caspase binding	1/451	12/18367	0.258015843644175	0.624928107989884	RIOK3	1
GO:0097677	STAT family protein binding	1/451	12/18367	0.258015843644175	0.624928107989884	PPARG	1
GO:0030331	estrogen receptor binding	2/451	41/18367	0.266729426641649	0.628462170361049	CTNNB1/NRIP1	2
GO:1902936	phosphatidylinositol bisphosphate binding	4/451	107/18367	0.268678585150157	0.628462170361049	MAPKAP1/PLEKHA5/GSN/SESTD1	4
GO:0017022	myosin binding	3/451	74/18367	0.273209137208026	0.628462170361049	GSN/CALD1/RHOA	3
GO:0019210	kinase inhibitor activity	3/451	74/18367	0.273209137208026	0.628462170361049	SH3BP5/WNK1/DNAJC3	3
GO:0090079	translation regulator activity, nucleic acid binding	4/451	108/18367	0.274128493470805	0.628462170361049	EIF1B/ABCF1/EIF4H/DENR	4
GO:0019199	transmembrane receptor protein kinase activity	5/451	143/18367	0.27514849007989	0.628462170361049	CLK4/EIF2AK2/EFEMP1/JAK1/WEE1	5
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/451	13/18367	0.276247107851011	0.628462170361049	PPP1R14B	1
GO:0008179	adenylate cyclase binding	1/451	13/18367	0.276247107851011	0.628462170361049	AKAP12	1
GO:0008195	phosphatidate phosphatase activity	1/451	13/18367	0.276247107851011	0.628462170361049	PLPP3	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/451	13/18367	0.276247107851011	0.628462170361049	SLC13A4	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/451	13/18367	0.276247107851011	0.628462170361049	DUSP4	1
GO:0045159	myosin II binding	1/451	13/18367	0.276247107851011	0.628462170361049	GSN	1
GO:0051011	microtubule minus-end binding	1/451	13/18367	0.276247107851011	0.628462170361049	MACF1	1
GO:0061783	peptidoglycan muralytic activity	1/451	13/18367	0.276247107851011	0.628462170361049	LYZ	1
GO:0070679	inositol 1,4,5 trisphosphate binding	1/451	13/18367	0.276247107851011	0.628462170361049	PLCL2	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/451	13/18367	0.276247107851011	0.628462170361049	HSD17B1	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/451	13/18367	0.276247107851011	0.628462170361049	LAPTM5	1
GO:0004866	endopeptidase inhibitor activity	6/451	180/18367	0.281699282410411	0.638585206033566	SPINT1/TNFAIP8/CST6/BIRC7/SERPINF1/CST3	6
GO:0032266	phosphatidylinositol-3-phosphate binding	2/451	43/18367	0.285033086289595	0.641687166428113	PLEKHA5/SESTD1	2
GO:0047485	protein N-terminus binding	4/451	110/18367	0.2850823675026	0.641687166428113	HAX1/ZMYND8/HSPA1B/SRRM2	4
GO:0004089	carbonate dehydratase activity	1/451	14/18367	0.294031381271475	0.643472764214004	CA2	1
GO:0004707	MAP kinase activity	1/451	14/18367	0.294031381271475	0.643472764214004	MAPK6	1
GO:0005313	L-glutamate transmembrane transporter activity	1/451	14/18367	0.294031381271475	0.643472764214004	SLC1A6	1
GO:0015373	anion:sodium symporter activity	1/451	14/18367	0.294031381271475	0.643472764214004	SLC13A4	1
GO:0043023	ribosomal large subunit binding	1/451	14/18367	0.294031381271475	0.643472764214004	RBM3	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/451	14/18367	0.294031381271475	0.643472764214004	HSD17B1	1
GO:0070411	I-SMAD binding	1/451	14/18367	0.294031381271475	0.643472764214004	CTNNB1	1
GO:0051879	Hsp90 protein binding	2/451	44/18367	0.29416998350341	0.643472764214004	CDC37/GBP1	2
GO:0008514	organic anion transmembrane transporter activity	6/451	185/18367	0.302956529079268	0.643472764214004	SLC25A24/SLC16A3/SLC2A3/SLC7A1/SLC1A6/SLC7A5	6
GO:0140223	general transcription initiation factor activity	2/451	45/18367	0.303290262673684	0.643472764214004	TAF7/TAF3	2
GO:0046906	tetrapyrrole binding	5/451	149/18367	0.303693799266772	0.643472764214004	HBA2/HBA1/HBG2/HMOX1/HBB	5
GO:0016835	carbon-oxygen lyase activity	3/451	79/18367	0.306776104926331	0.643472764214004	CA2/PTS/CDYL	3
GO:0019903	protein phosphatase binding	5/451	150/18367	0.308497198468351	0.643472764214004	ANKLE2/PPP1R15A/CTNNB1/GRB2/JAK1	5
GO:0140677	molecular function activator activity	5/451	150/18367	0.308497198468351	0.643472764214004	APOE/APOC1/DNAJC1/PSAP/DNAJA1	5
GO:0001846	opsonin binding	1/451	15/18367	0.311379599385492	0.643472764214004	CALR	1
GO:0004559	alpha-mannosidase activity	1/451	15/18367	0.311379599385492	0.643472764214004	MAN1A1	1
GO:0005041	low-density lipoprotein particle receptor activity	1/451	15/18367	0.311379599385492	0.643472764214004	LRP2	1
GO:0034483	heparan sulfate sulfotransferase activity	1/451	15/18367	0.311379599385492	0.643472764214004	HS6ST1	1
GO:0043138	3'-5' DNA helicase activity	1/451	15/18367	0.311379599385492	0.643472764214004	NAV2	1
GO:0050998	nitric-oxide synthase binding	1/451	15/18367	0.311379599385492	0.643472764214004	CD74	1
GO:0051371	muscle alpha-actinin binding	1/451	15/18367	0.311379599385492	0.643472764214004	PDLIM2	1
GO:0098847	sequence-specific single stranded DNA binding	1/451	15/18367	0.311379599385492	0.643472764214004	HNRNPA1	1
GO:1990825	sequence-specific mRNA binding	1/451	15/18367	0.311379599385492	0.643472764214004	SRSF4	1
GO:0030414	peptidase inhibitor activity	6/451	187/18367	0.311542306500446	0.643472764214004	SPINT1/TNFAIP8/CST6/BIRC7/SERPINF1/CST3	6
GO:0140296	general transcription initiation factor binding	2/451	46/18367	0.312389239230014	0.643472764214004	ZNHIT6/TAF7	2
GO:0005525	GTP binding	11/451	377/18367	0.322786246782984	0.643472764214004	GNL3/ARHGEF5/RAP1B/RHOB/TUBB6/RRAS2/MX1/HSP90AB1/RAB8B/GBP1/RHOA	11
GO:0008234	cysteine-type peptidase activity	6/451	190/18367	0.324494317777703	0.643472764214004	SFRP1/USP48/CTSD/CTSS/GGH/OTUD1	6
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/451	82/18367	0.327002900935895	0.643472764214004	MAPKAP1/GSN/SESTD1	3
GO:0005092	GDP-dissociation inhibitor activity	1/451	16/18367	0.328302430721431	0.643472764214004	CHML	1
GO:0005159	insulin-like growth factor receptor binding	1/451	16/18367	0.328302430721431	0.643472764214004	INSL4	1
GO:0005283	amino acid:sodium symporter activity	1/451	16/18367	0.328302430721431	0.643472764214004	SLC1A6	1
GO:0005521	lamin binding	1/451	16/18367	0.328302430721431	0.643472764214004	BNIP3L	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/451	16/18367	0.328302430721431	0.643472764214004	SLC1A6	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/451	16/18367	0.328302430721431	0.643472764214004	SLC1A6	1
GO:0015923	mannosidase activity	1/451	16/18367	0.328302430721431	0.643472764214004	MAN1A1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/451	16/18367	0.328302430721431	0.643472764214004	PIK3CA	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/451	16/18367	0.328302430721431	0.643472764214004	RNASE1	1
GO:0032183	SUMO binding	1/451	16/18367	0.328302430721431	0.643472764214004	SERBP1	1
GO:0035497	cAMP response element binding	1/451	16/18367	0.328302430721431	0.643472764214004	JUN	1
GO:0042577	lipid phosphatase activity	1/451	16/18367	0.328302430721431	0.643472764214004	PLPP3	1
GO:0070403	NAD+ binding	1/451	16/18367	0.328302430721431	0.643472764214004	HPGD	1
GO:1990404	protein ADP-ribosylase activity	1/451	16/18367	0.328302430721431	0.643472764214004	PARP14	1
GO:0070888	E-box binding	2/451	48/18367	0.330505732648732	0.645804146310559	PPARG/GATA3	2
GO:0004197	cysteine-type endopeptidase activity	4/451	119/18367	0.334999969508526	0.651763057861799	SFRP1/USP48/CTSD/CTSS	4
GO:0005539	glycosaminoglycan binding	7/451	230/18367	0.33620467425172	0.651763057861799	APOE/HDGF/SFRP1/ADAMTS1/NAV2/CCDC80/RPL29	7
GO:0015171	amino acid transmembrane transporter activity	3/451	84/18367	0.340487175599454	0.651763057861799	SLC7A1/SLC1A6/SLC7A5	3
GO:0061135	endopeptidase regulator activity	6/451	194/18367	0.341874982575719	0.651763057861799	SPINT1/TNFAIP8/CST6/BIRC7/SERPINF1/CST3	6
GO:0000400	four-way junction DNA binding	1/451	17/18367	0.344810283358597	0.651763057861799	HMGB3	1
GO:0004697	protein kinase C activity	1/451	17/18367	0.344810283358597	0.651763057861799	SMG1	1
GO:0015116	sulfate transmembrane transporter activity	1/451	17/18367	0.344810283358597	0.651763057861799	SLC13A4	1
GO:0015174	basic amino acid transmembrane transporter activity	1/451	17/18367	0.344810283358597	0.651763057861799	SLC7A1	1
GO:0042800	histone methyltransferase activity (H3-K4 specific)	1/451	17/18367	0.344810283358597	0.651763057861799	KMT2C	1
GO:0043395	heparan sulfate proteoglycan binding	1/451	17/18367	0.344810283358597	0.651763057861799	APOE	1
GO:0052745	inositol phosphate phosphatase activity	1/451	17/18367	0.344810283358597	0.651763057861799	IMPA2	1
GO:0030246	carbohydrate binding	8/451	271/18367	0.348875810946003	0.654990824159735	P4HA1/HLA-DRA/HLA-DRB1/SLC2A3/MRC2/GALNT1/PLOD2/CALR	8
GO:0019902	phosphatase binding	6/451	196/18367	0.350602209352626	0.654990824159735	ANKLE2/PPP1R15A/CTNNB1/WNK1/GRB2/JAK1	6
GO:0005179	hormone activity	4/451	122/18367	0.351758208044555	0.654990824159735	CGA/INHA/INSL4/CSH1	4
GO:0003697	single-stranded DNA binding	4/451	123/18367	0.357346890846117	0.654990824159735	ANXA1/YBX1/HNRNPA1/RTF1	4
GO:0016860	intramolecular oxidoreductase activity	2/451	51/18367	0.357416868320088	0.654990824159735	ERO1A/ERP44	2
GO:0051018	protein kinase A binding	2/451	51/18367	0.357416868320088	0.654990824159735	AKAP12/RDX	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/451	18/18367	0.360913311271691	0.654990824159735	SLC25A24	1
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/451	18/18367	0.360913311271691	0.654990824159735	HSD17B1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/451	18/18367	0.360913311271691	0.654990824159735	SLC25A24	1
GO:0008301	DNA binding, bending	1/451	18/18367	0.360913311271691	0.654990824159735	HMGB3	1
GO:0030228	lipoprotein particle receptor activity	1/451	18/18367	0.360913311271691	0.654990824159735	LRP2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/451	18/18367	0.360913311271691	0.654990824159735	SASH1	1
GO:0033549	MAP kinase phosphatase activity	1/451	18/18367	0.360913311271691	0.654990824159735	DUSP4	1
GO:0098918	structural constituent of synapse	1/451	18/18367	0.360913311271691	0.654990824159735	CTBP2	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4/451	124/18367	0.362934938013124	0.656788509983977	LDHA/HSD17B1/CTBP2/HPGD	4
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/451	19/18367	0.376621420521048	0.673898440651426	GALNT1	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/451	19/18367	0.376621420521048	0.673898440651426	MTHFD1L	1
GO:0035613	RNA stem-loop binding	1/451	19/18367	0.376621420521048	0.673898440651426	EIF4A3	1
GO:0052742	phosphatidylinositol kinase activity	1/451	19/18367	0.376621420521048	0.673898440651426	PIK3CA	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	2/451	54/18367	0.383926931664718	0.685046093754694	P4HA1/PLOD2	2
GO:0019001	guanyl nucleotide binding	11/451	398/18367	0.387850485593961	0.685902481761724	GNL3/ARHGEF5/RAP1B/RHOB/TUBB6/RRAS2/MX1/HSP90AB1/RAB8B/GBP1/RHOA	11
GO:0032561	guanyl ribonucleotide binding	11/451	398/18367	0.387850485593961	0.685902481761724	GNL3/ARHGEF5/RAP1B/RHOB/TUBB6/RRAS2/MX1/HSP90AB1/RAB8B/GBP1/RHOA	11
GO:0001972	retinoic acid binding	1/451	20/18367	0.391944275292414	0.685902481761724	RXRA	1
GO:0030296	protein tyrosine kinase activator activity	1/451	20/18367	0.391944275292414	0.685902481761724	PAK2	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/451	20/18367	0.391944275292414	0.685902481761724	KLF4	1
GO:0061608	nuclear import signal receptor activity	1/451	20/18367	0.391944275292414	0.685902481761724	NUTF2	1
GO:0097001	ceramide binding	1/451	20/18367	0.391944275292414	0.685902481761724	PSAP	1
GO:0030374	nuclear receptor coactivator activity	2/451	56/18367	0.40133674930113	0.69916009228863	MED4/TMF1	2
GO:0001848	complement binding	1/451	21/18367	0.406891303789886	0.69916009228863	CALR	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/451	21/18367	0.406891303789886	0.69916009228863	LPCAT1	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/451	21/18367	0.406891303789886	0.69916009228863	SLC25A24	1
GO:0140416	transcription regulator inhibitor activity	1/451	21/18367	0.406891303789886	0.69916009228863	TAF3	1
GO:0043175	RNA polymerase core enzyme binding	2/451	57/18367	0.409954602339683	0.69916009228863	SPTY2D1/RTF1	2
GO:0022804	active transmembrane transporter activity	11/451	406/18367	0.41298030989859	0.69916009228863	SLC16A3/UQCR10/SLC1A6/SLC7A5/NDUFB2/NDUFA3/SLC13A4/COX6A1/NDUFB1/NDUFA4/COX4I1	11
GO:0046982	protein heterodimerization activity	9/451	328/18367	0.41511246025628	0.69916009228863	TPM1/CEBPB/TAF7/SRI/TAF3/SNX2/MAPK6/MCL1/ATF4	9
GO:0005201	extracellular matrix structural constituent	5/451	172/18367	0.415444816795689	0.69916009228863	FBN2/HSPG2/EFEMP1/COL17A1/SPARC	5
GO:0060090	molecular adaptor activity	10/451	369/18367	0.420735140073025	0.69916009228863	KLF4/CDYL/PKP2/SASH1/GNB1/RB1CC1/KHDRBS1/GRB2/VAMP8/PDCD6	10
GO:0000062	fatty-acyl-CoA binding	1/451	22/18367	0.42147170398561	0.69916009228863	DBI	1
GO:0004602	glutathione peroxidase activity	1/451	22/18367	0.42147170398561	0.69916009228863	GSTP1	1
GO:0005355	glucose transmembrane transporter activity	1/451	22/18367	0.42147170398561	0.69916009228863	SLC2A3	1
GO:0005416	amino acid:cation symporter activity	1/451	22/18367	0.42147170398561	0.69916009228863	SLC1A6	1
GO:0008320	protein transmembrane transporter activity	1/451	22/18367	0.42147170398561	0.69916009228863	MCL1	1
GO:0015149	hexose transmembrane transporter activity	1/451	22/18367	0.42147170398561	0.69916009228863	SLC2A3	1
GO:0015296	anion:cation symporter activity	1/451	22/18367	0.42147170398561	0.69916009228863	SLC13A4	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/451	22/18367	0.42147170398561	0.69916009228863	HSPG2	1
GO:0070182	DNA polymerase binding	1/451	22/18367	0.42147170398561	0.69916009228863	HSP90AB1	1
GO:0120020	cholesterol transfer activity	1/451	22/18367	0.42147170398561	0.69916009228863	APOE	1
GO:0002020	protease binding	4/451	135/18367	0.424051236271679	0.70085192969522	SRI/RIOK3/CST3/PSAP	4
GO:0036002	pre-mRNA binding	2/451	59/18367	0.427004482115856	0.70085192969522	HNRNPA1/SRSF2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	4/451	136/18367	0.429548849004486	0.70085192969522	LDHA/HSD17B1/CTBP2/HPGD	4
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/451	23/18367	0.435694449229682	0.70085192969522	PARP14	1
GO:0005158	insulin receptor binding	1/451	23/18367	0.435694449229682	0.70085192969522	SNX2	1
GO:0005212	structural constituent of eye lens	1/451	23/18367	0.435694449229682	0.70085192969522	VIM	1
GO:0017134	fibroblast growth factor binding	1/451	23/18367	0.435694449229682	0.70085192969522	RPS19	1
GO:0030215	semaphorin receptor binding	1/451	23/18367	0.435694449229682	0.70085192969522	SEMA4C	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/451	23/18367	0.435694449229682	0.70085192969522	LPCAT1	1
GO:0071617	lysophospholipid acyltransferase activity	1/451	23/18367	0.435694449229682	0.70085192969522	LPCAT1	1
GO:0120015	sterol transfer activity	1/451	23/18367	0.435694449229682	0.70085192969522	APOE	1
GO:1901567	fatty acid derivative binding	1/451	23/18367	0.435694449229682	0.70085192969522	DBI	1
GO:0019955	cytokine binding	4/451	139/18367	0.445955244551965	0.707098773091277	CD74/HAX1/IFNAR1/GBP1	4
GO:0099106	ion channel regulator activity	4/451	139/18367	0.445955244551965	0.707098773091277	SRI/PKP2/WNK1/VAMP8	4
GO:0003924	GTPase activity	9/451	337/18367	0.446575227056598	0.707098773091277	RAP1B/RHOB/TUBB6/RRAS2/GNB1/MX1/RAB8B/GBP1/RHOA	9
GO:0001965	G-protein alpha-subunit binding	1/451	24/18367	0.449568293723653	0.707098773091277	SASH1	1
GO:0003707	steroid hormone receptor activity	1/451	24/18367	0.449568293723653	0.707098773091277	RXRA	1
GO:0004622	lysophospholipase activity	1/451	24/18367	0.449568293723653	0.707098773091277	GDPD3	1
GO:0015145	monosaccharide transmembrane transporter activity	1/451	24/18367	0.449568293723653	0.707098773091277	SLC2A3	1
GO:0043495	protein-membrane adaptor activity	1/451	24/18367	0.449568293723653	0.707098773091277	PDCD6	1
GO:0051537	2 iron, 2 sulfur cluster binding	1/451	24/18367	0.449568293723653	0.707098773091277	FDX1	1
GO:0019838	growth factor binding	4/451	141/18367	0.456812328291713	0.716722790940447	IGFBP3/HAX1/LRP2/RPS19	4
GO:0005160	transforming growth factor beta receptor binding	1/451	25/18367	0.463101777860961	0.717751417268691	FERMT2	1
GO:0008266	poly(U) RNA binding	1/451	25/18367	0.463101777860961	0.717751417268691	KHDRBS1	1
GO:0008327	methyl-CpG binding	1/451	25/18367	0.463101777860961	0.717751417268691	MBD2	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	1/451	25/18367	0.463101777860961	0.717751417268691	MEX3D	1
GO:0120227	acyl-CoA binding	1/451	25/18367	0.463101777860961	0.717751417268691	DBI	1
GO:0016836	hydro-lyase activity	2/451	64/18367	0.468452675672356	0.72428241360022	CA2/CDYL	2
GO:0004620	phospholipase activity	3/451	104/18367	0.472019414451328	0.726190881378503	HMOX1/GDPD3/PLCL2	3
GO:0005178	integrin binding	4/451	144/18367	0.472961141081184	0.726190881378503	SPP1/FERMT2/PLPP3/CALR	4
GO:0004364	glutathione transferase activity	1/451	26/18367	0.47630323343749	0.726190881378503	GSTP1	1
GO:0004435	phosphatidylinositol phospholipase C activity	1/451	26/18367	0.47630323343749	0.726190881378503	PLCL2	1
GO:0008198	ferrous iron binding	1/451	26/18367	0.47630323343749	0.726190881378503	FTL	1
GO:0030145	manganese ion binding	2/451	65/18367	0.476527140370823	0.726190881378503	PIM1/GALNT1	2
GO:0016247	channel regulator activity	4/451	145/18367	0.478304568016075	0.727159927986252	SRI/PKP2/WNK1/VAMP8	4
GO:0043022	ribosome binding	2/451	66/18367	0.484526583897328	0.729761504506968	SBDS/SERBP1	2
GO:0004190	aspartic-type endopeptidase activity	1/451	27/18367	0.48918078873544	0.729761504506968	CTSD	1
GO:0004683	calmodulin-dependent protein kinase activity	1/451	27/18367	0.48918078873544	0.729761504506968	PNCK	1
GO:0008139	nuclear localization sequence binding	1/451	27/18367	0.48918078873544	0.729761504506968	NUP58	1
GO:0015215	nucleotide transmembrane transporter activity	1/451	27/18367	0.48918078873544	0.729761504506968	SLC25A24	1
GO:0022884	macromolecule transmembrane transporter activity	1/451	27/18367	0.48918078873544	0.729761504506968	MCL1	1
GO:0045499	chemorepellent activity	1/451	27/18367	0.48918078873544	0.729761504506968	SEMA4C	1
GO:0051119	sugar transmembrane transporter activity	1/451	27/18367	0.48918078873544	0.729761504506968	SLC2A3	1
GO:0008022	protein C-terminus binding	5/451	189/18367	0.49649865846076	0.738129080621294	CTNNB1/NCL/HSPG2/SASH1/PPARG	5
GO:0061134	peptidase regulator activity	6/451	230/18367	0.498231370982499	0.738129080621294	SPINT1/TNFAIP8/CST6/BIRC7/SERPINF1/CST3	6
GO:0004629	phospholipase C activity	1/451	28/18367	0.501742373483549	0.738129080621294	PLCL2	1
GO:0008187	poly-pyrimidine tract binding	1/451	28/18367	0.501742373483549	0.738129080621294	KHDRBS1	1
GO:0070001	aspartic-type peptidase activity	1/451	28/18367	0.501742373483549	0.738129080621294	CTSD	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/451	28/18367	0.501742373483549	0.738129080621294	PDCD6	1
GO:0000149	SNARE binding	3/451	110/18367	0.509269094896232	0.745757272296321	TNFAIP2/GOLGA2/VAMP8	3
GO:0008047	enzyme activator activity	3/451	110/18367	0.509269094896232	0.745757272296321	APOE/APOC1/PSAP	3
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/451	29/18367	0.513995723696697	0.749234041178023	MTHFD1L	1
GO:0046625	sphingolipid binding	1/451	29/18367	0.513995723696697	0.749234041178023	PSAP	1
GO:0005310	dicarboxylic acid transmembrane transporter activity	1/451	30/18367	0.525948386397798	0.753668510094894	SLC1A6	1
GO:0005343	organic acid:sodium symporter activity	1/451	30/18367	0.525948386397798	0.753668510094894	SLC1A6	1
GO:0017147	Wnt-protein binding	1/451	30/18367	0.525948386397798	0.753668510094894	SFRP1	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/451	30/18367	0.525948386397798	0.753668510094894	HSD17B1	1
GO:0016829	lyase activity	5/451	196/18367	0.528676631419302	0.753668510094894	CA2/PTS/CDYL/RNASE1/AMD1	5
GO:0003678	DNA helicase activity	2/451	72/18367	0.530888174316151	0.753668510094894	ANXA1/NAV2	2
GO:0004386	helicase activity	4/451	156/18367	0.535556331829323	0.753668510094894	ANXA1/NAV2/EIF4A3/HELZ	4
GO:0008157	protein phosphatase 1 binding	1/451	31/18367	0.537607724224846	0.753668510094894	PPP1R15A	1
GO:0016411	acylglycerol O-acyltransferase activity	1/451	31/18367	0.537607724224846	0.753668510094894	LPCAT1	1
GO:0031210	phosphatidylcholine binding	1/451	31/18367	0.537607724224846	0.753668510094894	APOC1	1
GO:0071813	lipoprotein particle binding	1/451	31/18367	0.537607724224846	0.753668510094894	APOE	1
GO:0071814	protein-lipid complex binding	1/451	31/18367	0.537607724224846	0.753668510094894	APOE	1
GO:0090482	vitamin transmembrane transporter activity	1/451	31/18367	0.537607724224846	0.753668510094894	SLC2A3	1
GO:0140142	nucleocytoplasmic carrier activity	1/451	31/18367	0.537607724224846	0.753668510094894	NUTF2	1
GO:0015370	solute:sodium symporter activity	2/451	73/18367	0.538334650067781	0.753668510094894	SLC1A6/SLC13A4	2
GO:0070063	RNA polymerase binding	2/451	73/18367	0.538334650067781	0.753668510094894	SPTY2D1/RTF1	2
GO:0106306	protein serine phosphatase activity	2/451	73/18367	0.538334650067781	0.753668510094894	DUSP4/PPM1G	2
GO:0106307	protein threonine phosphatase activity	2/451	73/18367	0.538334650067781	0.753668510094894	DUSP4/PPM1G	2
GO:0019905	syntaxin binding	2/451	74/18367	0.545699247647219	0.762303554279119	GOLGA2/VAMP8	2
GO:0015605	organophosphate ester transmembrane transporter activity	1/451	32/18367	0.548980919925904	0.763538965049783	SLC25A24	1
GO:0051721	protein phosphatase 2A binding	1/451	32/18367	0.548980919925904	0.763538965049783	ANKLE2	1
GO:0008200	ion channel inhibitor activity	1/451	33/18367	0.560074980744743	0.774046162595641	WNK1	1
GO:0019239	deaminase activity	1/451	33/18367	0.560074980744743	0.774046162595641	CDA	1
GO:0001618	virus receptor activity	2/451	76/18367	0.560180974814114	0.774046162595641	HSPA1B/PLSCR1	2
GO:0008083	growth factor activity	4/451	162/18367	0.565430121596464	0.77539706844302	HDGF/INHA/EFEMP1/CSH1	4
GO:0140272	exogenous protein binding	2/451	77/18367	0.567297365806193	0.77539706844302	HSPA1B/PLSCR1	2
GO:0046943	carboxylic acid transmembrane transporter activity	4/451	163/18367	0.570305926515174	0.77539706844302	SLC16A3/SLC7A1/SLC1A6/SLC7A5	4
GO:0008376	acetylgalactosaminyltransferase activity	1/451	34/18367	0.570896742699806	0.77539706844302	GALNT1	1
GO:0016229	steroid dehydrogenase activity	1/451	34/18367	0.570896742699806	0.77539706844302	HSD17B1	1
GO:0016248	channel inhibitor activity	1/451	34/18367	0.570896742699806	0.77539706844302	WNK1	1
GO:0016831	carboxy-lyase activity	1/451	34/18367	0.570896742699806	0.77539706844302	AMD1	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/451	34/18367	0.570896742699806	0.77539706844302	WNK1	1
GO:0005342	organic acid transmembrane transporter activity	4/451	164/18367	0.575151182322437	0.779513410934878	SLC16A3/SLC7A1/SLC1A6/SLC7A5	4
GO:0005096	GTPase activator activity	11/451	462/18367	0.58441221449624	0.790383398373895	ARHGEF5/VAV2/SH3BP5/ARHGAP29/ARHGAP21/JUN/SH2D3A/CHN2/NET1/CHML/ARFGAP3	11
GO:0000217	DNA secondary structure binding	1/451	36/18367	0.591749882913312	0.795241931256919	HMGB3	1
GO:0005484	SNAP receptor activity	1/451	36/18367	0.591749882913312	0.795241931256919	VAMP8	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/451	36/18367	0.591749882913312	0.795241931256919	CDA	1
GO:0030674	protein-macromolecule adaptor activity	7/451	296/18367	0.593163943978209	0.795464068029725	KLF4/CDYL/GNB1/KHDRBS1/GRB2/VAMP8/PDCD6	7
GO:0035591	signaling adaptor activity	2/451	81/18367	0.594927556519239	0.796153053577217	GNB1/KHDRBS1	2
GO:0008242	omega peptidase activity	3/451	126/18367	0.601278934141628	0.801972491032994	USP48/GGH/OTUD1	3
GO:0015035	protein-disulfide reductase activity	1/451	37/18367	0.601794114150347	0.801972491032994	ERO1A	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	4/451	170/18367	0.603561825461142	0.802649024673794	P4HA1/HMOX1/MICAL3/PLOD2	4
GO:0004520	endodeoxyribonuclease activity	1/451	38/18367	0.611591760332464	0.804925519280536	DFFB	1
GO:0005501	retinoid binding	1/451	38/18367	0.611591760332464	0.804925519280536	RXRA	1
GO:0015175	neutral amino acid transmembrane transporter activity	1/451	38/18367	0.611591760332464	0.804925519280536	SLC7A5	1
GO:0019840	isoprenoid binding	1/451	38/18367	0.611591760332464	0.804925519280536	RXRA	1
GO:0140303	intramembrane lipid transporter activity	1/451	38/18367	0.611591760332464	0.804925519280536	PLSCR1	1
GO:0030165	PDZ domain binding	2/451	84/18367	0.614770531020074	0.80744088300987	PLEKHA2/ARHGAP29	2
GO:0016298	lipase activity	3/451	129/18367	0.617218182313492	0.808987617559042	HMOX1/GDPD3/PLCL2	3
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	1/451	39/18367	0.621148861979584	0.809165044382585	POLR2L	1
GO:0050997	quaternary ammonium group binding	1/451	39/18367	0.621148861979584	0.809165044382585	APOC1	1
GO:0050660	flavin adenine dinucleotide binding	2/451	85/18367	0.621217456645988	0.809165044382585	ERO1A/MICAL3	2
GO:0015078	proton transmembrane transporter activity	3/451	130/18367	0.622434649525065	0.809165044382585	UQCR10/COX6A1/COX4I1	3
GO:0015144	carbohydrate transmembrane transporter activity	1/451	40/18367	0.630471311960335	0.811333789330774	SLC2A3	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/451	40/18367	0.630471311960335	0.811333789330774	HMOX1	1
GO:0017080	sodium channel regulator activity	1/451	40/18367	0.630471311960335	0.811333789330774	PKP2	1
GO:0042287	MHC protein binding	1/451	40/18367	0.630471311960335	0.811333789330774	CD74	1
GO:0043014	alpha-tubulin binding	1/451	40/18367	0.630471311960335	0.811333789330774	BEX4	1
GO:0000287	magnesium ion binding	5/451	221/18367	0.635122431125787	0.812489300199207	STK3/WNK1/PLSCR1/WEE1/PDCD6	5
GO:0016877	ligase activity, forming carbon-sulfur bonds	1/451	41/18367	0.639564859093302	0.812489300199207	UBA6	1
GO:0030020	extracellular matrix structural constituent conferring tensile strength	1/451	41/18367	0.639564859093302	0.812489300199207	COL17A1	1
GO:0048487	beta-tubulin binding	1/451	41/18367	0.639564859093302	0.812489300199207	GABARAP	1
GO:0005085	guanyl-nucleotide exchange factor activity	5/451	223/18367	0.642976774455965	0.812489300199207	ARHGEF5/VAV2/SH3BP5/SH2D3A/NET1	5
GO:0043178	alcohol binding	2/451	89/18367	0.646172683469149	0.812489300199207	OSBPL1A/PLCL2	2
GO:0051117	ATPase binding	2/451	89/18367	0.646172683469149	0.812489300199207	ZNHIT6/RDX	2
GO:0015036	disulfide oxidoreductase activity	1/451	42/18367	0.648435111660634	0.812489300199207	ERO1A	1
GO:0019894	kinesin binding	1/451	42/18367	0.648435111660634	0.812489300199207	SHTN1	1
GO:0048018	receptor ligand activity	11/451	487/18367	0.653730555764579	0.812489300199207	HDGF/WNT7A/CGA/SPP1/SEMA4C/INHA/EFEMP1/INSL4/FAM3C/CSH1/FAM3B	11
GO:0008509	anion transmembrane transporter activity	7/451	314/18367	0.654679104247894	0.812489300199207	SLC25A24/SLC16A3/SLC2A3/SLC7A1/SLC1A6/SLC7A5/SLC13A4	7
GO:0030695	GTPase regulator activity	11/451	488/18367	0.656368625429571	0.812489300199207	ARHGEF5/VAV2/SH3BP5/ARHGAP29/ARHGAP21/JUN/SH2D3A/CHN2/NET1/CHML/ARFGAP3	11
GO:0060589	nucleoside-triphosphatase regulator activity	11/451	488/18367	0.656368625429571	0.812489300199207	ARHGEF5/VAV2/SH3BP5/ARHGAP29/ARHGAP21/JUN/SH2D3A/CHN2/NET1/CHML/ARFGAP3	11
GO:0004180	carboxypeptidase activity	1/451	43/18367	0.657087540836135	0.812489300199207	CPVL	1
GO:0005246	calcium channel regulator activity	1/451	43/18367	0.657087540836135	0.812489300199207	SRI	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/451	43/18367	0.657087540836135	0.812489300199207	MICAL3	1
GO:0018024	histone-lysine N-methyltransferase activity	1/451	43/18367	0.657087540836135	0.812489300199207	KMT2C	1
GO:0030544	Hsp70 protein binding	1/451	43/18367	0.657087540836135	0.812489300199207	DNAJA1	1
GO:0034062	5'-3' RNA polymerase activity	1/451	43/18367	0.657087540836135	0.812489300199207	POLR2L	1
GO:0097747	RNA polymerase activity	1/451	43/18367	0.657087540836135	0.812489300199207	POLR2L	1
GO:0016407	acetyltransferase activity	2/451	91/18367	0.658154597963565	0.812489300199207	LPCAT1/SAT1	2
GO:0016887	ATP hydrolysis activity	6/451	272/18367	0.661072175553701	0.814512525778932	RNF213/HSPA2/KIF2A/NAV2/EIF4A3/HSPA1B	6
GO:0051213	dioxygenase activity	2/451	92/18367	0.664022828104409	0.816568612939205	P4HA1/PLOD2	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/451	44/18367	0.665527484029919	0.816842017971211	CLK4	1
GO:0008188	neuropeptide receptor activity	1/451	45/18367	0.673760148151651	0.824336459863101	KISS1R	1
GO:0030546	signaling receptor activator activity	11/451	495/18367	0.67452082254524	0.824336459863101	HDGF/WNT7A/CGA/SPP1/SEMA4C/INHA/EFEMP1/INSL4/FAM3C/CSH1/FAM3B	11
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	2/451	94/18367	0.675515905884676	0.824336459863101	LYZ/MAN1A1	2
GO:0042578	phosphoric ester hydrolase activity	8/451	366/18367	0.679840006285314	0.828026929261463	IMPA2/HMOX1/GDPD3/GNB1/PLPP3/DUSP4/PPM1G/PLCL2	8
GO:0004864	protein phosphatase inhibitor activity	1/451	46/18367	0.681790612794355	0.828817977767183	PPP1R14B	1
GO:0005125	cytokine activity	5/451	235/18367	0.68784482057708	0.833647601142088	WNT7A/SPP1/INHA/FAM3C/FAM3B	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	1/451	47/18367	0.689623833340708	0.833647601142088	DUSP4	1
GO:0015293	symporter activity	3/451	144/18367	0.690312188033227	0.833647601142088	SLC16A3/SLC1A6/SLC13A4	3
GO:0004896	cytokine receptor activity	2/451	97/18367	0.692154118321782	0.833647601142088	CD74/IFNAR1	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/451	48/18367	0.697264643993729	0.833647601142088	MTHFD1L	1
GO:0048020	CCR chemokine receptor binding	1/451	48/18367	0.697264643993729	0.833647601142088	JAK1	1
GO:0120013	lipid transfer activity	1/451	48/18367	0.697264643993729	0.833647601142088	APOE	1
GO:0004722	protein serine/threonine phosphatase activity	2/451	98/18367	0.69754187034338	0.833647601142088	DUSP4/PPM1G	2
GO:0004867	serine-type endopeptidase inhibitor activity	2/451	98/18367	0.69754187034338	0.833647601142088	SPINT1/SERPINF1	2
GO:0052689	carboxylic ester hydrolase activity	3/451	147/18367	0.703602352343753	0.835241654764703	CA2/GDPD3/PON2	3
GO:0016763	pentosyltransferase activity	1/451	49/18367	0.704717760733662	0.835241654764703	PARP14	1
GO:0019212	phosphatase inhibitor activity	1/451	49/18367	0.704717760733662	0.835241654764703	PPP1R14B	1
GO:0043539	protein serine/threonine kinase activator activity	1/451	49/18367	0.704717760733662	0.835241654764703	STK3	1
GO:0005496	steroid binding	2/451	100/18367	0.708083247819119	0.835241654764703	HSD17B1/OSBPL1A	2
GO:0000993	RNA polymerase II complex binding	1/451	50/18367	0.711987784202879	0.835241654764703	RTF1	1
GO:0005048	signal sequence binding	1/451	50/18367	0.711987784202879	0.835241654764703	NUP58	1
GO:0015485	cholesterol binding	1/451	50/18367	0.711987784202879	0.835241654764703	OSBPL1A	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/451	50/18367	0.711987784202879	0.835241654764703	SLC25A24	1
GO:0030159	signaling receptor complex adaptor activity	1/451	50/18367	0.711987784202879	0.835241654764703	GNB1	1
GO:0004497	monooxygenase activity	2/451	102/18367	0.718316441606128	0.839899893876762	HMOX1/MICAL3	2
GO:0008238	exopeptidase activity	2/451	103/18367	0.723319028774683	0.839899893876762	CPVL/GGH	2
GO:0008146	sulfotransferase activity	1/451	52/18367	0.725996394028683	0.839899893876762	HS6ST1	1
GO:0016830	carbon-carbon lyase activity	1/451	52/18367	0.725996394028683	0.839899893876762	AMD1	1
GO:0017046	peptide hormone binding	1/451	52/18367	0.725996394028683	0.839899893876762	SLC40A1	1
GO:1901682	sulfur compound transmembrane transporter activity	1/451	52/18367	0.725996394028683	0.839899893876762	SLC13A4	1
GO:0015294	solute:cation symporter activity	2/451	104/18367	0.728246472192788	0.839899893876762	SLC1A6/SLC13A4	2
GO:0005516	calmodulin binding	4/451	201/18367	0.730796298967742	0.839899893876762	PNCK/AKAP12/TJP1/CALD1	4
GO:0050661	NADP binding	1/451	53/18367	0.73274362997152	0.839899893876762	HSD17B1	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/451	53/18367	0.73274362997152	0.839899893876762	SLC25A24	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/451	53/18367	0.73274362997152	0.839899893876762	SLC16A3	1
GO:0005319	lipid transporter activity	3/451	154/18367	0.732912873518423	0.839899893876762	APOE/OSBPL1A/PLSCR1	3
GO:1990782	protein tyrosine kinase binding	2/451	105/18367	0.733099436413626	0.839899893876762	CBL/KHDRBS1	2
GO:0008374	O-acyltransferase activity	1/451	54/18367	0.739325077109384	0.843996548599781	LPCAT1	1
GO:0015459	potassium channel regulator activity	1/451	54/18367	0.739325077109384	0.843996548599781	WNK1	1
GO:0016853	isomerase activity	3/451	158/18367	0.748611426088241	0.853068834379623	ISYNA1/ERO1A/ERP44	3
GO:0042054	histone methyltransferase activity	1/451	56/18367	0.752006764832142	0.855407694996562	KMT2C	1
GO:0004536	deoxyribonuclease activity	1/451	57/18367	0.758114839162365	0.857629573029649	DFFB	1
GO:0005548	phospholipid transporter activity	1/451	57/18367	0.758114839162365	0.857629573029649	PLSCR1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/451	57/18367	0.758114839162365	0.857629573029649	ERO1A	1
GO:0008094	ATP-dependent activity, acting on DNA	2/451	111/18367	0.760691850489406	0.857629573029649	ANXA1/NAV2	2
GO:0032182	ubiquitin-like protein binding	2/451	111/18367	0.760691850489406	0.857629573029649	UBXN2A/SERBP1	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/451	58/18367	0.764072796974368	0.858402771909475	SLC16A3	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/451	58/18367	0.764072796974368	0.858402771909475	GSTP1	1
GO:0004843	thiol-dependent deubiquitinase	2/451	113/18367	0.769325388625616	0.861891584557901	USP48/OTUD1	2
GO:0016279	protein-lysine N-methyltransferase activity	1/451	59/18367	0.769884319644342	0.861891584557901	KMT2C	1
GO:0101005	deubiquitinase activity	2/451	114/18367	0.773539724762673	0.862176719060942	USP48/OTUD1	2
GO:0001786	phosphatidylserine binding	1/451	60/18367	0.775552998464552	0.862176719060942	CPNE1	1
GO:0016278	lysine N-methyltransferase activity	1/451	60/18367	0.775552998464552	0.862176719060942	KMT2C	1
GO:0032934	sterol binding	1/451	60/18367	0.775552998464552	0.862176719060942	OSBPL1A	1
GO:0005507	copper ion binding	1/451	61/18367	0.781082336842904	0.86530338881553	F5	1
GO:0043621	protein self-association	1/451	61/18367	0.781082336842904	0.86530338881553	PPARG	1
GO:1990841	promoter-specific chromatin binding	1/451	62/18367	0.786475752448926	0.869765719288135	KLF4	1
GO:0022853	active ion transmembrane transporter activity	5/451	267/18367	0.788046695174128	0.869992625348214	UQCR10/SLC1A6/SLC13A4/COX6A1/COX4I1	5
GO:0005126	cytokine receptor binding	5/451	271/18367	0.798611467329582	0.880130630949729	FERMT2/GRB2/JAK1/CSH1/GATA3	5
GO:0019783	ubiquitin-like protein-specific protease activity	2/451	125/18367	0.815623655934655	0.891759541615996	USP48/OTUD1	2
GO:0008080	N-acetyltransferase activity	1/451	68/18367	0.816162971369114	0.891759541615996	SAT1	1
GO:0016782	transferase activity, transferring sulphur-containing groups	1/451	68/18367	0.816162971369114	0.891759541615996	HS6ST1	1
GO:0051536	iron-sulfur cluster binding	1/451	68/18367	0.816162971369114	0.891759541615996	FDX1	1
GO:0051540	metal cluster binding	1/451	68/18367	0.816162971369114	0.891759541615996	FDX1	1
GO:0003777	microtubule motor activity	1/451	69/18367	0.820693847368487	0.89364441157902	KIF2A	1
GO:0004521	endoribonuclease activity	1/451	69/18367	0.820693847368487	0.89364441157902	RNASE1	1
GO:0004519	endonuclease activity	2/451	129/18367	0.829106665620106	0.901264412969297	DFFB/RNASE1	2
GO:0000049	tRNA binding	1/451	72/18367	0.83362878292966	0.903097848173799	EIF2AK4	1
GO:0042379	chemokine receptor binding	1/451	72/18367	0.83362878292966	0.903097848173799	JAK1	1
GO:0015291	secondary active transmembrane transporter activity	4/451	240/18367	0.844147294821621	0.912940283194181	SLC16A3/SLC1A6/SLC7A5/SLC13A4	4
GO:0008236	serine-type peptidase activity	3/451	191/18367	0.851456467224203	0.916853567565268	CPVL/PRSS23/CTSS	3
GO:0003724	RNA helicase activity	1/451	77/18367	0.85315093130638	0.916853567565268	EIF4A3	1
GO:0038024	cargo receptor activity	1/451	77/18367	0.85315093130638	0.916853567565268	LRP2	1
GO:0001664	G protein-coupled receptor binding	5/451	295/18367	0.853523022866882	0.916853567565268	WNT7A/SFRP1/HSPA1B/JAK1/DNAJA1	5
GO:0030971	receptor tyrosine kinase binding	1/451	78/18367	0.856771977232068	0.918794191072099	CBL	1
GO:0008186	ATP-dependent activity, acting on RNA	1/451	79/18367	0.860303927490055	0.92026417268221	EIF4A3	1
GO:0017171	serine hydrolase activity	3/451	195/18367	0.861032098773308	0.92026417268221	CPVL/PRSS23/CTSS	3
GO:0016798	hydrolase activity, acting on glycosyl bonds	2/451	144/18367	0.872097133902257	0.930529102672928	LYZ/MAN1A1	2
GO:0003730	mRNA 3'-UTR binding	3/451	201/18367	0.874381000376165	0.931405848226785	MEX3D/SERBP1/HNRNPR	3
GO:0019787	ubiquitin-like protein transferase activity	8/451	458/18367	0.878215864322401	0.933929057718479	RNF213/TRIM24/UBE2D1/RSPRY1/CBL/BIRC7/UBE2J1/UFC1	8
GO:0019842	vitamin binding	2/451	148/18367	0.881753194626512	0.936127974961813	P4HA1/PLOD2	2
GO:0008276	protein methyltransferase activity	1/451	88/18367	0.888426009300681	0.941642875082419	KMT2C	1
GO:0015081	sodium ion transmembrane transporter activity	2/451	152/18367	0.890732284136671	0.942519044842292	SLC1A6/SLC13A4	2
GO:0004518	nuclease activity	3/451	210/18367	0.892279254188834	0.94259019057759	DFFB/RNASE1/PLSCR1	3
GO:0043130	ubiquitin binding	1/451	92/18367	0.899037491966234	0.948157090037236	UBXN2A	1
GO:0072341	modified amino acid binding	1/451	93/18367	0.901529097499652	0.949213281169055	CPNE1	1
GO:0016410	N-acyltransferase activity	1/451	94/18367	0.903959346871857	0.950201491678833	SAT1	1
GO:0004175	endopeptidase activity	7/451	430/18367	0.906791100135457	0.951215235580237	SFRP1/ADAMTS1/CPNE1/USP48/PRSS23/CTSD/CTSS	7
GO:0016791	phosphatase activity	4/451	275/18367	0.908828078705079	0.951215235580237	IMPA2/PLPP3/DUSP4/PPM1G	4
GO:0004842	ubiquitin-protein transferase activity	7/451	433/18367	0.910343601894256	0.951215235580237	RNF213/TRIM24/UBE2D1/RSPRY1/CBL/BIRC7/UBE2J1	7
GO:0008170	N-methyltransferase activity	1/451	97/18367	0.910896850398658	0.951215235580237	KMT2C	1
GO:0016874	ligase activity	2/451	165/18367	0.915726249980073	0.95469332444731	MTHFD1L/UBA6	2
GO:0004725	protein tyrosine phosphatase activity	1/451	102/18367	0.921365896347575	0.958886038541424	DUSP4	1
GO:0140097	catalytic activity, acting on DNA	3/451	229/18367	0.922758464090883	0.958886038541424	DFFB/ANXA1/NAV2	3
GO:0004252	serine-type endopeptidase activity	2/451	174/18367	0.92977358286194	0.96303377607001	PRSS23/CTSS	2
GO:0004721	phosphoprotein phosphatase activity	2/451	174/18367	0.92977358286194	0.96303377607001	DUSP4/PPM1G	2
GO:0004222	metalloendopeptidase activity	1/451	111/18367	0.937213654497979	0.969164119992229	ADAMTS1	1
GO:0003774	cytoskeletal motor activity	1/451	114/18367	0.941753149081149	0.972064082727327	KIF2A	1
GO:0061630	ubiquitin protein ligase activity	4/451	304/18367	0.943084899355631	0.972064082727327	TRIM24/UBE2D1/CBL/BIRC7	4
GO:0004540	ribonuclease activity	1/451	116/18367	0.944596023874749	0.972064082727327	RNASE1	1
GO:0016746	acyltransferase activity	3/451	250/18367	0.94712898363231	0.97309864931255	LPCAT1/SAT1/KMT2C	3
GO:0061659	ubiquitin-like protein ligase activity	4/451	316/18367	0.953458635216538	0.978024397154484	TRIM24/UBE2D1/CBL/BIRC7	4
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/451	125/18367	0.955769763997322	0.978818874061566	CDA	1
GO:0016779	nucleotidyltransferase activity	1/451	132/18367	0.96288051536833	0.984518279758629	POLR2L	1
GO:0015085	calcium ion transmembrane transporter activity	1/451	135/18367	0.965567292619	0.985683277881896	TMEM165	1
GO:0008194	UDP-glycosyltransferase activity	1/451	143/18367	0.971820764392262	0.990051000229723	GALNT1	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	2/451	222/18367	0.974197385608616	0.990051000229723	LPCAT1/SAT1	2
GO:0008528	G protein-coupled peptide receptor activity	1/451	147/18367	0.974508598342287	0.990051000229723	KISS1R	1
GO:0015103	inorganic anion transmembrane transporter activity	1/451	152/18367	0.97751148704992	0.990507958826296	SLC13A4	1
GO:0001653	peptide receptor activity	1/451	153/18367	0.978068298432873	0.990507958826296	KISS1R	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/451	156/18367	0.979657540408789	0.990542624191109	KMT2C	1
GO:0046873	metal ion transmembrane transporter activity	5/451	430/18367	0.981772285888023	0.991107680048607	SLC25A37/TMEM165/SLC1A6/SLC40A1/SLC13A4	5
GO:0016757	glycosyltransferase activity	2/451	270/18367	0.990867783245063	0.996406549722683	GALNT1/PARP14	2
GO:0008237	metallopeptidase activity	1/451	190/18367	0.9913348720547	0.996406549722683	ADAMTS1	1
GO:0016758	hexosyltransferase activity	1/451	197/18367	0.992732551295428	0.996406549722683	GALNT1	1
GO:0008168	methyltransferase activity	1/451	214/18367	0.99526050619007	0.996406549722683	KMT2C	1
GO:0140098	catalytic activity, acting on RNA	3/451	386/18367	0.996322603145678	0.996406549722683	POLR2L/EIF4A3/RNASE1	3
GO:0016741	transferase activity, transferring one-carbon groups	1/451	225/18367	0.996406549722683	0.996406549722683	KMT2C	1