ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	22/236	182/18367	1.89236029424038e-15	9.95381514770442e-13	RPL39/RPS29/RPS28/RPL34/RPS27/RPL28/RPS15/RPS12/RPS27A/RPL36/RPL18/RPL12/RPS15A/RPLP1/RPS14/RPLP2/RPS23/RPL10/RPL37A/RPL35A/RPL41/RPS24	22
GO:0005178	integrin binding	16/236	144/18367	5.31307405053537e-11	1.3973384752908e-08	FN1/FBN1/LAMB1/EGFR/SPP1/FBLN1/LAMA5/ITGB5/DST/ITGAV/UTRN/PLPP3/ITGB4/P4HB/ITGB1/CALR	16
GO:0031720	haptoglobin binding	5/236	10/18367	8.02809116906258e-08	1.40759198497564e-05	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0019838	growth factor binding	12/236	141/18367	2.83155324695803e-07	3.61718495483625e-05	LRP2/CRIM1/ITGA6/EGFR/FLT1/NRP1/IGF1R/ITGAV/ITGB4/IL6ST/COL4A1/NRP2	12
GO:0031994	insulin-like growth factor I binding	5/236	13/18367	3.97265311109396e-07	3.61718495483625e-05	LRP2/ITGA6/IGF1R/ITGAV/ITGB4	5
GO:0050840	extracellular matrix binding	8/236	56/18367	5.50970155341608e-07	3.61718495483625e-05	ITGA6/ADGRG1/DAG1/SPP1/BCAM/ITGAV/ITGB1/TINAGL1	8
GO:0001618	virus receptor activity	9/236	76/18367	5.52691022347858e-07	3.61718495483625e-05	EGFR/DAG1/DPP4/ITGB5/ITGAV/CD46/TFRC/ITGB1/SCARB2	9
GO:0005344	oxygen carrier activity	5/236	14/18367	6.11503128632937e-07	3.61718495483625e-05	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0140272	exogenous protein binding	9/236	77/18367	6.18909973260956e-07	3.61718495483625e-05	EGFR/DAG1/DPP4/ITGB5/ITGAV/CD46/TFRC/ITGB1/SCARB2	9
GO:0005520	insulin-like growth factor binding	6/236	29/18367	1.56630465891434e-06	8.23876250588944e-05	LRP2/CRIM1/ITGA6/IGF1R/ITGAV/ITGB4	6
GO:0005201	extracellular matrix structural constituent	12/236	172/18367	2.36779614310669e-06	0.000113223706479465	FN1/FBN1/FBN2/LAMC1/LAMB1/COL4A2/FBLN1/LAMA5/COL4A1/VWA1/EFEMP1/TINAGL1	12
GO:0038024	cargo receptor activity	8/236	77/18367	6.47326378056018e-06	0.000283744729047888	LRP2/LRP1/COLEC12/LGALS3BP/OLR1/TFRC/SCARB2/FOLR1	8
GO:0097493	structural molecule activity conferring elasticity	4/236	11/18367	8.16971733733932e-06	0.000330559332264652	FBN1/FBN2/LAMC1/AHNAK	4
GO:0005539	glycosaminoglycan binding	13/236	230/18367	9.15477738068159e-06	0.000343958064445608	FN1/FBN1/APOE/FSTL1/ADGRG1/NRP1/APLP2/AOC1/APP/PTPRF/GNS/EXTL2/NRP2	13
GO:0008201	heparin binding	11/236	166/18367	1.02490532871611e-05	0.000359400135269782	FN1/FBN1/APOE/FSTL1/ADGRG1/NRP1/APLP2/AOC1/APP/PTPRF/NRP2	11
GO:0043236	laminin binding	5/236	28/18367	2.59168938989242e-05	0.000852017886927132	ITGA6/DAG1/BCAM/ITGB1/TINAGL1	5
GO:1901681	sulfur compound binding	13/236	265/18367	4.07247505238185e-05	0.00126007169267815	FN1/FBN1/LRP1/APOE/FSTL1/ADGRG1/NRP1/APLP2/AOC1/APP/PTPRF/NRP2/HADHA	13
GO:0004601	peroxidase activity	6/236	51/18367	4.69001352845772e-05	0.0013705261755382	HBA1/HBA2/HBG1/HBB/HBG2/PRDX4	6
GO:0002020	protease binding	9/236	135/18367	6.29546899448147e-05	0.00174285089005119	FN1/LRP1/ADAMTSL4/DPP4/ITGAV/ITGB1/TIMP3/PSAP/DVL3	9
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	6/236	55/18367	7.23320393452258e-05	0.00190233263477944	HBA1/HBA2/HBG1/HBB/HBG2/PRDX4	6
GO:0043394	proteoglycan binding	5/236	36/18367	9.14308489241499e-05	0.00229012507305252	FN1/LRP1/APOE/PTPRF/CTSL	5
GO:0016209	antioxidant activity	7/236	86/18367	0.000120050078790367	0.00287028824744241	HBA1/HBA2/HBG1/APOE/HBB/HBG2/PRDX4	7
GO:0019825	oxygen binding	5/236	39/18367	0.000135327765856404	0.0030948871669769	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0061134	peptidase regulator activity	11/236	230/18367	0.000198862786566937	0.00425048227326598	FN1/CRIM1/SPINT1/ITIH5/FBLN1/APLP2/APP/SERPINF1/BIRC6/TIMP3/CTSC	11
GO:0004714	transmembrane receptor protein tyrosine kinase activity	8/236	124/18367	0.000202019119451805	0.00425048227326598	CRIM1/EGFR/MET/FLT1/NRP1/IGF1R/EFEMP1/NRP2	8
GO:0043177	organic acid binding	8/236	135/18367	0.000360309903633015	0.00728934651196023	HBA1/HBA2/HBG1/HBB/HBG2/GLDC/SLC19A1/FOLR1	8
GO:0004713	protein tyrosine kinase activity	8/236	136/18367	0.000378662193793318	0.00737690051612167	CRIM1/EGFR/MET/FLT1/NRP1/IGF1R/EFEMP1/NRP2	8
GO:0017154	semaphorin receptor activity	3/236	12/18367	0.000422953324296646	0.00774358228659673	MET/NRP1/NRP2	3
GO:0001968	fibronectin binding	4/236	28/18367	0.000426927540515789	0.00774358228659673	FBLN1/ITGAV/CTSL/ITGB1	4
GO:0019199	transmembrane receptor protein kinase activity	8/236	143/18367	0.000529559835940358	0.00928494912348761	CRIM1/EGFR/MET/FLT1/NRP1/IGF1R/EFEMP1/NRP2	8
GO:0008013	beta-catenin binding	6/236	85/18367	0.000792551019131708	0.0134478011633316	CDH1/TBL1X/CTNNB1/DLG5/DVL3/KANK1	6
GO:0005041	low-density lipoprotein particle receptor activity	3/236	15/18367	0.000850157256071088	0.0139744598966685	LRP2/LRP1/OLR1	3
GO:0098631	cell adhesion mediator activity	5/236	59/18367	0.000955477146623155	0.0152297266401145	BCAM/CD47/ITGB1/DSC2/S100A11	5
GO:0045296	cadherin binding	12/236	332/18367	0.0012703076974561	0.0196524073194679	ITGA6/EGFR/RPL34/CDH1/AHNAK/CD46/LDHA/ITGB1/S100A11/CTNNB1/SLK/EPS8L2	12
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	6/236	94/18367	0.0013410548536121	0.0201541386571418	LYZ/GLB1/GANAB/AGL/MAN2A1/GM2A	6
GO:0030228	lipoprotein particle receptor activity	3/236	18/18367	0.00148190094063282	0.0216522192992462	LRP2/LRP1/OLR1	3
GO:0004867	serine-type endopeptidase inhibitor activity	6/236	98/18367	0.0016617511551758	0.0236238137195263	CRIM1/SPINT1/ITIH5/APLP2/APP/SERPINF1	6
GO:0016500	protein-hormone receptor activity	3/236	20/18367	0.00203145643243211	0.0281196337752445	LGR5/IGF1R/LGR4	3
GO:0016504	peptidase activator activity	4/236	43/18367	0.00221370211602506	0.029856597769979	FN1/FBLN1/APP/CTSC	4
GO:0004866	endopeptidase inhibitor activity	8/236	180/18367	0.00232394490026094	0.0305598754384314	CRIM1/SPINT1/ITIH5/APLP2/APP/SERPINF1/BIRC6/TIMP3	8
GO:0140104	molecular carrier activity	5/236	73/18367	0.00247959895705924	0.0318114402783698	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0051087	chaperone binding	6/236	107/18367	0.0025938801780619	0.0324852612776323	FN1/LRP2/GRN/CALR/SCARB2/CTSC	6
GO:0030414	peptidase inhibitor activity	8/236	187/18367	0.00293991639986102	0.035962698286672	CRIM1/SPINT1/ITIH5/APLP2/APP/SERPINF1/BIRC6/TIMP3	8
GO:0005044	scavenger receptor activity	4/236	47/18367	0.0030741062259603	0.0367495426103436	LRP1/COLEC12/LGALS3BP/SCARB2	4
GO:0015026	coreceptor activity	4/236	48/18367	0.00332026100703946	0.0388101619933945	LRP1/NRP1/ITGAV/ITGB1	4
GO:0061135	endopeptidase regulator activity	8/236	194/18367	0.0036763605977907	0.0420383842269111	CRIM1/SPINT1/ITIH5/APLP2/APP/SERPINF1/BIRC6/TIMP3	8
GO:0016758	hexosyltransferase activity	8/236	197/18367	0.00403254063760927	0.0451301356464357	GALNT11/EXTL2/CHPF/AGL/RPN2/B4GALT1/B3GNT2/STT3B	8
GO:0045499	chemorepellent activity	3/236	27/18367	0.00487885873505384	0.0523730549926188	SEMA6D/SEMA6A/DPP4	3
GO:0048027	mRNA 5'-UTR binding	3/236	27/18367	0.00487885873505384	0.0523730549926188	RPS14/DHX36/RPL41	3
GO:0042562	hormone binding	5/236	86/18367	0.00502761679541622	0.0528905286877787	LRP2/EGFR/IGF1R/SLC40A1/CALR	5
GO:0015101	organic cation transmembrane transporter activity	3/236	28/18367	0.0054130904783984	0.0547554921468762	ATP13A3/SLC44A2/SLC44A1	3
GO:0070325	lipoprotein particle receptor binding	3/236	28/18367	0.0054130904783984	0.0547554921468762	LRP1/APOE/HSP90B1	3
GO:0033218	amide binding	12/236	400/18367	0.0057596168697474	0.0571614806318327	LRP1/APOE/IGF1R/MME/SLC19A1/ITM2B/SLC40A1/CALR/NKTR/PSAP/FOLR1/HADHA	12
GO:0008239	dipeptidyl-peptidase activity	2/236	10/18367	0.00691207791823186	0.0673287589812955	DPP4/CTSC	2
GO:0008509	anion transmembrane transporter activity	10/236	314/18367	0.00760570904393022	0.072738235583769	SLC26A2/SLC6A4/SLC13A4/SLC19A1/ANO6/SLC38A1/SLC2A1/SLC38A9/SLC22A11/CLDN4	10
GO:0022853	active ion transmembrane transporter activity	9/236	267/18367	0.00782013036853272	0.0734533673901466	SLC26A2/SLC6A4/ATP2B1/SLC13A4/ATP2B4/ATP13A3/SLC19A1/SLC38A1/SLC22A11	9
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/236	11/18367	0.00837692906557582	0.077302889271805	CD47/DSC2	2
GO:0030246	carbohydrate binding	9/236	271/18367	0.00857581292825944	0.0777737517286977	COLEC12/CANX/GANAB/GALNT11/OLR1/AGL/MAN2A1/LMAN1/CALR	9
GO:0019955	cytokine binding	6/236	139/18367	0.00920167715669252	0.0819289291724069	NRP1/CSF3R/ITGAV/IL6ST/ITGB1/NRP2	6
GO:0008376	acetylgalactosaminyltransferase activity	3/236	34/18367	0.00934550522879166	0.0819289291724069	GALNT11/EXTL2/CHPF	3
GO:0017166	vinculin binding	2/236	12/18367	0.00996772421383166	0.0859511956799254	DAG1/UTRN	2
GO:0016798	hydrolase activity, acting on glycosyl bonds	6/236	144/18367	0.0108360072490268	0.09193128730626	LYZ/GLB1/GANAB/AGL/MAN2A1/GM2A	6
GO:0008022	protein C-terminus binding	7/236	189/18367	0.0112764071472679	0.093790358405796	FN1/FBLN1/BCAM/DST/TBL1X/CTNNB1/PRRC2C	7
GO:0005542	folic acid binding	2/236	13/18367	0.0116810130703658	0.093790358405796	SLC19A1/FOLR1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/236	13/18367	0.0116810130703658	0.093790358405796	SLC26A2/SLC13A4	2
GO:0003779	actin binding	12/236	440/18367	0.0117683719672672	0.093790358405796	EGFR/DAG1/SLC6A4/TMSB10/DST/DIAPH2/UTRN/SYNE2/P4HB/ITGB1/PHACTR2/EPS8L2	12
GO:0005518	collagen binding	4/236	69/18367	0.0119741157567208	0.0940057445975393	FN1/ADGRG1/CTSL/ITGB1	4
GO:0015373	anion:sodium symporter activity	2/236	14/18367	0.0135134125611452	0.101543642959463	SLC6A4/SLC13A4	2
GO:0015926	glucosidase activity	2/236	14/18367	0.0135134125611452	0.101543642959463	GANAB/AGL	2
GO:0044548	S100 protein binding	2/236	14/18367	0.0135134125611452	0.101543642959463	AHNAK/S100A11	2
GO:0015103	inorganic anion transmembrane transporter activity	6/236	152/18367	0.0138628883247983	0.102702524772449	SLC26A2/SLC6A4/SLC13A4/ANO6/SLC22A11/CLDN4	6
GO:0005319	lipid transporter activity	6/236	154/18367	0.0147032462888375	0.107415382610118	APOE/ATP10D/ANO6/SLC27A2/SLC2A1/GM2A	6
GO:0001846	opsonin binding	2/236	15/18367	0.0154616056850028	0.109902764733939	ITGAV/CALR	2
GO:0050998	nitric-oxide synthase binding	2/236	15/18367	0.0154616056850028	0.109902764733939	SLC6A4/ATP2B4	2
GO:0005324	long-chain fatty acid transporter activity	2/236	17/18367	0.0196924284439658	0.131116675462355	SLC27A2/SLC2A1	2
GO:0008484	sulfuric ester hydrolase activity	2/236	17/18367	0.0196924284439658	0.131116675462355	STS/GNS	2
GO:0015116	sulfate transmembrane transporter activity	2/236	17/18367	0.0196924284439658	0.131116675462355	SLC26A2/SLC13A4	2
GO:0034185	apolipoprotein binding	2/236	17/18367	0.0196924284439658	0.131116675462355	LRP1/CANX	2
GO:0043395	heparan sulfate proteoglycan binding	2/236	17/18367	0.0196924284439658	0.131116675462355	LRP1/APOE	2
GO:0048156	tau protein binding	3/236	45/18367	0.019996148951837	0.131474679358328	APOE/LGMN/TAOK1	3
GO:0019829	ATPase-coupled cation transmembrane transporter activity	3/236	47/18367	0.0224284220601667	0.14564629634133	ATP2B1/ATP2B4/ATP13A3	3
GO:0030165	PDZ domain binding	4/236	84/18367	0.0230539751532836	0.14788281622716	CRIM1/ATP2B1/ATP2B4/ADRB1	4
GO:0016757	glycosyltransferase activity	8/236	270/18367	0.0237736361584381	0.15066183878721	GALNT11/EXTL2/CHPF/AGL/RPN2/B4GALT1/B3GNT2/STT3B	8
GO:0098632	cell-cell adhesion mediator activity	3/236	49/18367	0.0250146558940505	0.156639392860364	CD47/DSC2/S100A11	3
GO:0003756	protein disulfide isomerase activity	2/236	20/18367	0.0268278652759707	0.162200656725984	P4HB/PDIA4	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/236	20/18367	0.0268278652759707	0.162200656725984	AOC1/GLDC	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/236	20/18367	0.0268278652759707	0.162200656725984	P4HB/PDIA4	2
GO:0015662	P-type ion transporter activity	2/236	21/18367	0.0294047234078495	0.171854272361431	ATP2B1/ATP2B4	2
GO:0051010	microtubule plus-end binding	2/236	21/18367	0.0294047234078495	0.171854272361431	DST/CLIP1	2
GO:0140358	P-type transmembrane transporter activity	2/236	21/18367	0.0294047234078495	0.171854272361431	ATP2B1/ATP2B4	2
GO:0072341	modified amino acid binding	4/236	93/18367	0.031941822613345	0.183390550101368	MME/SLC19A1/SCARB2/FOLR1	4
GO:0015296	anion:cation symporter activity	2/236	22/18367	0.0320759137059427	0.183390550101368	SLC6A4/SLC13A4	2
GO:0008514	organic anion transmembrane transporter activity	6/236	185/18367	0.0325522008341697	0.184112447728745	SLC26A2/SLC19A1/SLC38A1/SLC2A1/SLC38A9/SLC22A11	6
GO:0020037	heme binding	5/236	139/18367	0.0338014041999428	0.189144027757127	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0030215	semaphorin receptor binding	2/236	23/18367	0.0348386086267149	0.190886543100542	SEMA6D/SEMA6A	2
GO:0050750	low-density lipoprotein particle receptor binding	2/236	23/18367	0.0348386086267149	0.190886543100542	APOE/HSP90B1	2
GO:0008194	UDP-glycosyltransferase activity	5/236	143/18367	0.037488136643704	0.203286184274106	GALNT11/EXTL2/CHPF/B4GALT1/B3GNT2	5
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/236	25/18367	0.0406274839151754	0.218061801422268	ZFP36L1/DHX36	2
GO:0019902	phosphatase binding	6/236	196/18367	0.0412796477021009	0.219324188801061	EGFR/MET/ATP2B4/HSP90B1/CTNNB1/CTSC	6
GO:0046906	tetrapyrrole binding	5/236	149/18367	0.0434644456418068	0.226261871242993	HBA1/HBA2/HBG1/HBB/HBG2	5
GO:0005507	copper ion binding	3/236	61/18367	0.0437320841731615	0.226261871242993	F5/AOC1/SNCG	3
GO:0008238	exopeptidase activity	4/236	103/18367	0.0438758761725956	0.226261871242993	DPP4/MME/TFRC/CTSC	4
GO:0019903	protein phosphatase binding	5/236	150/18367	0.0445129894359013	0.227318761585282	EGFR/MET/ATP2B4/HSP90B1/CTNNB1	5
GO:0004709	MAP kinase kinase kinase activity	2/236	27/18367	0.0467498423800938	0.236446318191628	EGFR/MAP3K1	2
GO:0042626	ATPase-coupled transmembrane transporter activity	4/236	109/18367	0.0520843689924124	0.260917886571514	SLC26A2/ATP2B1/ATP2B4/ATP13A3	4
GO:0015301	anion:anion antiporter activity	2/236	29/18367	0.0531850358724899	0.26145167167224	SLC26A2/SLC19A1	2
GO:0035250	UDP-galactosyltransferase activity	2/236	29/18367	0.0531850358724899	0.26145167167224	B4GALT1/B3GNT2	2
GO:0097110	scaffold protein binding	3/236	67/18367	0.0550878903750025	0.267803757713132	ATP2B4/IL6ST/PSAP	3
GO:0030546	signaling receptor activator activity	11/236	495/18367	0.0555914542563634	0.267803757713132	FBN1/SEMA6D/SEMA6A/SPP1/DPP4/APP/GRN/FAM3B/INSL4/EFEMP1/CSH1	11
GO:0042277	peptide binding	8/236	321/18367	0.0560521969989331	0.267803757713132	LRP1/APOE/IGF1R/MME/ITM2B/SLC40A1/CALR/NKTR	8
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/236	30/18367	0.05651372073414	0.267803757713132	SLC26A2/SLC19A1	2
GO:0046943	carboxylic acid transmembrane transporter activity	5/236	163/18367	0.0595198559803386	0.269353565054996	SLC26A2/SLC19A1/SLC27A2/SLC38A1/SLC38A9	5
GO:0042910	xenobiotic transmembrane transporter activity	2/236	31/18367	0.059913245459001	0.269353565054996	SLC19A1/SLC2A1	2
GO:0071813	lipoprotein particle binding	2/236	31/18367	0.059913245459001	0.269353565054996	APOE/COLEC12	2
GO:0071814	protein-lipid complex binding	2/236	31/18367	0.059913245459001	0.269353565054996	APOE/COLEC12	2
GO:0090482	vitamin transmembrane transporter activity	2/236	31/18367	0.059913245459001	0.269353565054996	SLC19A1/SLC2A1	2
GO:0140318	protein transporter activity	2/236	31/18367	0.059913245459001	0.269353565054996	LRP2/IGF1R	2
GO:0005342	organic acid transmembrane transporter activity	5/236	164/18367	0.06078022358291	0.270935572920429	SLC26A2/SLC19A1/SLC27A2/SLC38A1/SLC38A9	5
GO:0008378	galactosyltransferase activity	2/236	32/18367	0.0633812575547916	0.280155810704373	B4GALT1/B3GNT2	2
GO:0019956	chemokine binding	2/236	33/18367	0.066915452831354	0.289520428862474	ITGAV/ITGB1	2
GO:0140323	solute:anion antiporter activity	2/236	33/18367	0.066915452831354	0.289520428862474	SLC26A2/SLC19A1	2
GO:0004197	cysteine-type endopeptidase activity	4/236	119/18367	0.0674916545910224	0.289520428862474	CTSL/LGMN/USP25/CTSC	4
GO:0015370	solute:sodium symporter activity	3/236	73/18367	0.0677015451522516	0.289520428862474	SLC6A4/SLC13A4/SLC38A1	3
GO:0051082	unfolded protein binding	4/236	122/18367	0.072526549877706	0.307652945448979	CANX/HSP90B1/LMAN1/CALR	4
GO:0097718	disordered domain specific binding	2/236	36/18367	0.0778928027437964	0.327772913945895	FN1/CTNNB1	2
GO:0022804	active transmembrane transporter activity	9/236	406/18367	0.0795461927381926	0.332073788732455	SLC26A2/SLC6A4/ATP2B1/SLC13A4/ATP2B4/ATP13A3/SLC19A1/SLC38A1/SLC22A11	9
GO:0015035	protein-disulfide reductase activity	2/236	37/18367	0.0816696256229805	0.338253725021163	P4HB/PDIA4	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/236	38/18367	0.0855018061897555	0.348635271750476	SLC38A1/SLC38A9	2
GO:0140303	intramembrane lipid transporter activity	2/236	38/18367	0.0855018061897555	0.348635271750476	ATP10D/ANO6	2
GO:0015291	secondary active transmembrane transporter activity	6/236	240/18367	0.0899346080762965	0.363114694765919	SLC26A2/SLC6A4/SLC13A4/SLC19A1/SLC38A1/SLC22A11	6
GO:0044325	transmembrane transporter binding	4/236	133/18367	0.0925568183943225	0.363114694765919	AKAP9/TCAF1/CTNNB1/PRKCSH	4
GO:0017080	sodium channel regulator activity	2/236	40/18367	0.0933241565108492	0.363114694765919	ATP2B4/PRSS8	2
GO:0042169	SH2 domain binding	2/236	40/18367	0.0933241565108492	0.363114694765919	DAG1/ARHGAP5	2
GO:0043014	alpha-tubulin binding	2/236	40/18367	0.0933241565108492	0.363114694765919	TAOK1/EML4	2
GO:0001540	amyloid-beta binding	3/236	84/18367	0.0938480245708022	0.363114694765919	LRP1/APOE/ITM2B	3
GO:0003714	transcription corepressor activity	5/236	187/18367	0.0938851682284506	0.363114694765919	TBL1X/N4BP2L2/DNMT3A/SF1/TLE4	5
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/236	41/18367	0.0973103902516524	0.370907719364994	COL4A2/COL4A1	2
GO:0048487	beta-tubulin binding	2/236	41/18367	0.0973103902516524	0.370907719364994	TAOK1/EML4	2
GO:0048018	receptor ligand activity	10/236	487/18367	0.0985445450019953	0.372909573173018	FBN1/SEMA6D/SEMA6A/SPP1/DPP4/GRN/FAM3B/INSL4/EFEMP1/CSH1	10
GO:0008307	structural constituent of muscle	2/236	42/18367	0.101344108158428	0.378063836108747	DAG1/KRT19	2
GO:0015036	disulfide oxidoreductase activity	2/236	42/18367	0.101344108158428	0.378063836108747	P4HB/PDIA4	2
GO:0004175	endopeptidase activity	9/236	430/18367	0.103886726706687	0.384819846814909	ADAMTS6/DPP4/PRSS8/MME/CTSL/SPPL2A/LGMN/USP25/CTSC	9
GO:0008375	acetylglucosaminyltransferase activity	2/236	44/18367	0.109546574502333	0.402947539777811	EXTL2/B3GNT2	2
GO:0043130	ubiquitin binding	3/236	92/18367	0.11507108627171	0.414442809966174	N4BP2/USP25/UBXN7	3
GO:0005516	calmodulin binding	5/236	201/18367	0.117746075379349	0.414442809966174	EGFR/ATP2B1/ATP2B4/EEA1/UBR4	5
GO:0004300	enoyl-CoA hydratase activity	1/236	10/18367	0.121338769457777	0.414442809966174	HADHA	1
GO:0008172	S-methyltransferase activity	1/236	10/18367	0.121338769457777	0.414442809966174	DNMT3A	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/236	10/18367	0.121338769457777	0.414442809966174	MAN2A1	1
GO:0019531	oxalate transmembrane transporter activity	1/236	10/18367	0.121338769457777	0.414442809966174	SLC26A2	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/236	10/18367	0.121338769457777	0.414442809966174	SLC27A2	1
GO:0043208	glycosphingolipid binding	1/236	10/18367	0.121338769457777	0.414442809966174	PSAP	1
GO:0045294	alpha-catenin binding	1/236	10/18367	0.121338769457777	0.414442809966174	CTNNB1	1
GO:0051880	G-quadruplex DNA binding	1/236	10/18367	0.121338769457777	0.414442809966174	DHX36	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/236	10/18367	0.121338769457777	0.414442809966174	ADRB1	1
GO:0043021	ribonucleoprotein complex binding	4/236	149/18367	0.12580225099014	0.417760392451622	NEAT1/RPN2/RPLP1/YTHDF3	4
GO:0002162	dystroglycan binding	1/236	11/18367	0.132634953496998	0.417760392451622	DAG1	1
GO:0005247	voltage-gated chloride channel activity	1/236	11/18367	0.132634953496998	0.417760392451622	ANO6	1
GO:0015378	sodium:chloride symporter activity	1/236	11/18367	0.132634953496998	0.417760392451622	SLC6A4	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/236	11/18367	0.132634953496998	0.417760392451622	P4HB	1
GO:0017128	phospholipid scramblase activity	1/236	11/18367	0.132634953496998	0.417760392451622	ANO6	1
GO:0019107	myristoyltransferase activity	1/236	11/18367	0.132634953496998	0.417760392451622	ZDHHC17	1
GO:0043560	insulin receptor substrate binding	1/236	11/18367	0.132634953496998	0.417760392451622	IGF1R	1
GO:0047676	arachidonate-CoA ligase activity	1/236	11/18367	0.132634953496998	0.417760392451622	SLC27A2	1
GO:0048407	platelet-derived growth factor binding	1/236	11/18367	0.132634953496998	0.417760392451622	COL4A1	1
GO:0097371	MDM2/MDM4 family protein binding	1/236	11/18367	0.132634953496998	0.417760392451622	RPS15	1
GO:1901612	cardiolipin binding	1/236	11/18367	0.132634953496998	0.417760392451622	MME	1
GO:1990226	histone methyltransferase binding	1/236	11/18367	0.132634953496998	0.417760392451622	CTNNB1	1
GO:0016860	intramolecular oxidoreductase activity	2/236	51/18367	0.139489351782912	0.427639904121209	P4HB/PDIA4	2
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/236	12/18367	0.143786519795468	0.427639904121209	CDKN1C	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/236	12/18367	0.143786519795468	0.427639904121209	CDK6	1
GO:0031543	peptidyl-proline dioxygenase activity	1/236	12/18367	0.143786519795468	0.427639904121209	P4HB	1
GO:0043176	amine binding	1/236	12/18367	0.143786519795468	0.427639904121209	SLC6A4	1
GO:0045295	gamma-catenin binding	1/236	12/18367	0.143786519795468	0.427639904121209	CDH1	1
GO:0051378	serotonin binding	1/236	12/18367	0.143786519795468	0.427639904121209	SLC6A4	1
GO:0070410	co-SMAD binding	1/236	12/18367	0.143786519795468	0.427639904121209	TRIM33	1
GO:0017046	peptide hormone binding	2/236	52/18367	0.143901640740407	0.427639904121209	IGF1R/SLC40A1	2
GO:1901682	sulfur compound transmembrane transporter activity	2/236	52/18367	0.143901640740407	0.427639904121209	SLC26A2/SLC13A4	2
GO:0015294	solute:cation symporter activity	3/236	104/18367	0.149862030191516	0.442512685455794	SLC6A4/SLC13A4/SLC38A1	3
GO:0002161	aminoacyl-tRNA editing activity	1/236	13/18367	0.154795312022559	0.442512685455794	IARS2	1
GO:0008195	phosphatidate phosphatase activity	1/236	13/18367	0.154795312022559	0.442512685455794	PLPP3	1
GO:0016594	glycine binding	1/236	13/18367	0.154795312022559	0.442512685455794	GLDC	1
GO:0031386	protein tag	1/236	13/18367	0.154795312022559	0.442512685455794	RPS27A	1
GO:0031404	chloride ion binding	1/236	13/18367	0.154795312022559	0.442512685455794	CTSC	1
GO:0061783	peptidoglycan muralytic activity	1/236	13/18367	0.154795312022559	0.442512685455794	LYZ	1
GO:0005080	protein kinase C binding	2/236	55/18367	0.157306899985088	0.447261780498142	ITGAV/PRKCSH	2
GO:0051287	NAD binding	2/236	56/18367	0.161826673895522	0.45324021777122	LDHA/HADHA	2
GO:0004065	arylsulfatase activity	1/236	14/18367	0.165663150442668	0.45324021777122	STS	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/236	14/18367	0.165663150442668	0.45324021777122	B3GNT2	1
GO:0070411	I-SMAD binding	1/236	14/18367	0.165663150442668	0.45324021777122	CTNNB1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	2/236	57/18367	0.166369816236013	0.45324021777122	P4HB/PDIA4	2
GO:0008047	enzyme activator activity	3/236	110/18367	0.168381469209733	0.45324021777122	APOE/PSAP/GM2A	3
GO:0008094	ATP-dependent activity, acting on DNA	3/236	111/18367	0.171531112695867	0.45324021777122	DHX36/BPTF/SMARCA2	3
GO:0032182	ubiquitin-like protein binding	3/236	111/18367	0.171531112695867	0.45324021777122	N4BP2/USP25/UBXN7	3
GO:0004467	long-chain fatty acid-CoA ligase activity	1/236	15/18367	0.176391832211072	0.45324021777122	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/236	15/18367	0.176391832211072	0.45324021777122	MAN2A1	1
GO:0005452	inorganic anion exchanger activity	1/236	15/18367	0.176391832211072	0.45324021777122	SLC22A11	1
GO:0005545	1-phosphatidylinositol binding	1/236	15/18367	0.176391832211072	0.45324021777122	EEA1	1
GO:0015929	hexosaminidase activity	1/236	15/18367	0.176391832211072	0.45324021777122	GM2A	1
GO:0032794	GTPase activating protein binding	1/236	15/18367	0.176391832211072	0.45324021777122	CDH1	1
GO:0042809	vitamin D receptor binding	1/236	15/18367	0.176391832211072	0.45324021777122	MED13	1
GO:1901611	phosphatidylglycerol binding	1/236	15/18367	0.176391832211072	0.45324021777122	MME	1
GO:0003712	transcription coregulator activity	9/236	489/18367	0.179439478612346	0.45324021777122	PAGE4/TBL1X/CTNNB1/MED13/N4BP2L2/DNMT3A/SF1/SMARCA2/TLE4	9
GO:0001786	phosphatidylserine binding	2/236	60/18367	0.180126218606452	0.45324021777122	MME/SCARB2	2
GO:0015179	L-amino acid transmembrane transporter activity	2/236	61/18367	0.184749748587242	0.45324021777122	SLC38A1/SLC38A9	2
GO:0043621	protein self-association	2/236	61/18367	0.184749748587242	0.45324021777122	SLC2A1/CTSC	2
GO:0005159	insulin-like growth factor receptor binding	1/236	16/18367	0.186983131666074	0.45324021777122	INSL4	1
GO:0005283	amino acid:sodium symporter activity	1/236	16/18367	0.186983131666074	0.45324021777122	SLC38A1	1
GO:0008191	metalloendopeptidase inhibitor activity	1/236	16/18367	0.186983131666074	0.45324021777122	TIMP3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/236	16/18367	0.186983131666074	0.45324021777122	SLC22A11	1
GO:0015923	mannosidase activity	1/236	16/18367	0.186983131666074	0.45324021777122	MAN2A1	1
GO:0016004	phospholipase activator activity	1/236	16/18367	0.186983131666074	0.45324021777122	GM2A	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/236	16/18367	0.186983131666074	0.45324021777122	AOC1	1
GO:0032183	SUMO binding	1/236	16/18367	0.186983131666074	0.45324021777122	USP25	1
GO:0035497	cAMP response element binding	1/236	16/18367	0.186983131666074	0.45324021777122	CREB3L2	1
GO:0042577	lipid phosphatase activity	1/236	16/18367	0.186983131666074	0.45324021777122	PLPP3	1
GO:0070403	NAD+ binding	1/236	16/18367	0.186983131666074	0.45324021777122	HADHA	1
GO:0140327	flippase activity	1/236	16/18367	0.186983131666074	0.45324021777122	ATP10D	1
GO:0046873	metal ion transmembrane transporter activity	8/236	430/18367	0.190226014599488	0.454190186629801	SLC6A4/ITGAV/ATP2B1/SLC13A4/ATP2B4/SLC38A1/SLC40A1/ZDHHC17	8
GO:0031406	carboxylic acid binding	4/236	176/18367	0.19116406543093	0.454190186629801	GLDC/SLC19A1/PSAP/FOLR1	4
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/236	17/18367	0.197438800617456	0.454190186629801	PTPRF	1
GO:0008308	voltage-gated anion channel activity	1/236	17/18367	0.197438800617456	0.454190186629801	ANO6	1
GO:0015095	magnesium ion transmembrane transporter activity	1/236	17/18367	0.197438800617456	0.454190186629801	ZDHHC17	1
GO:0015108	chloride transmembrane transporter activity	1/236	17/18367	0.197438800617456	0.454190186629801	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/236	17/18367	0.197438800617456	0.454190186629801	SLC38A9	1
GO:0015377	cation:chloride symporter activity	1/236	17/18367	0.197438800617456	0.454190186629801	SLC6A4	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/236	17/18367	0.197438800617456	0.454190186629801	PTPRF	1
GO:0030169	low-density lipoprotein particle binding	1/236	17/18367	0.197438800617456	0.454190186629801	COLEC12	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/236	17/18367	0.197438800617456	0.454190186629801	B3GNT2	1
GO:0016836	hydro-lyase activity	2/236	64/18367	0.198717431281637	0.454190186629801	HACD3/HADHA	2
GO:0030145	manganese ion binding	2/236	65/18367	0.203401805670911	0.454190186629801	EXTL2/B4GALT1	2
GO:0015399	primary active transmembrane transporter activity	4/236	181/18367	0.204294083563362	0.454190186629801	SLC26A2/ATP2B1/ATP2B4/ATP13A3	4
GO:0005179	hormone activity	3/236	122/18367	0.207195197135745	0.454190186629801	FBN1/INSL4/CSH1	3
GO:0000295	adenine nucleotide transmembrane transporter activity	1/236	18/18367	0.207760568631313	0.454190186629801	SLC19A1	1
GO:0005229	intracellular calcium activated chloride channel activity	1/236	18/18367	0.207760568631313	0.454190186629801	ANO6	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/236	18/18367	0.207760568631313	0.454190186629801	SLC19A1	1
GO:0046624	sphingolipid transporter activity	1/236	18/18367	0.207760568631313	0.454190186629801	ATP10D	1
GO:0048038	quinone binding	1/236	18/18367	0.207760568631313	0.454190186629801	AOC1	1
GO:0060229	lipase activator activity	1/236	18/18367	0.207760568631313	0.454190186629801	GM2A	1
GO:0061778	intracellular chloride channel activity	1/236	18/18367	0.207760568631313	0.454190186629801	ANO6	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/236	18/18367	0.207760568631313	0.454190186629801	S100A11	1
GO:0043022	ribosome binding	2/236	66/18367	0.208098545585137	0.454190186629801	RPN2/YTHDF3	2
GO:0019843	rRNA binding	2/236	68/18367	0.217524806495975	0.46984334172845	RPL12/RPS14	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/236	19/18367	0.217950143311296	0.46984334172845	GALNT11	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/236	19/18367	0.217950143311296	0.46984334172845	SLC6A4	1
GO:0016018	cyclosporin A binding	1/236	20/18367	0.228009210576313	0.478970188080126	NKTR	1
GO:0016408	C-acyltransferase activity	1/236	20/18367	0.228009210576313	0.478970188080126	HADHA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/236	20/18367	0.228009210576313	0.478970188080126	CTSC	1
GO:0030506	ankyrin binding	1/236	20/18367	0.228009210576313	0.478970188080126	CDH1	1
GO:0031690	adrenergic receptor binding	1/236	20/18367	0.228009210576313	0.478970188080126	ADRB1	1
GO:0097001	ceramide binding	1/236	20/18367	0.228009210576313	0.478970188080126	PSAP	1
GO:0008234	cysteine-type peptidase activity	4/236	190/18367	0.228558017505916	0.478970188080126	CTSL/LGMN/USP25/CTSC	4
GO:0048029	monosaccharide binding	2/236	71/18367	0.231730630165108	0.479090197908866	COLEC12/LMAN1	2
GO:0000049	tRNA binding	2/236	72/18367	0.236479652734008	0.479090197908866	IARS2/RPL35A	2
GO:0001848	complement binding	1/236	21/18367	0.237939434934736	0.479090197908866	CALR	1
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/236	21/18367	0.237939434934736	0.479090197908866	LPCAT3	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/236	21/18367	0.237939434934736	0.479090197908866	SLC19A1	1
GO:0003725	double-stranded RNA binding	2/236	74/18367	0.245992653222655	0.479090197908866	TFRC/DHX36	2
GO:0005254	chloride channel activity	2/236	74/18367	0.245992653222655	0.479090197908866	ANO6/CLDN4	2
GO:0000062	fatty-acyl-CoA binding	1/236	22/18367	0.247742459755155	0.479090197908866	HADHA	1
GO:0005355	glucose transmembrane transporter activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC2A1	1
GO:0005416	amino acid:cation symporter activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC38A1	1
GO:0005537	mannose binding	1/236	22/18367	0.247742459755155	0.479090197908866	LMAN1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC26A2	1
GO:0015149	hexose transmembrane transporter activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC2A1	1
GO:0015645	fatty acid ligase activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC27A2	1
GO:0017075	syntaxin-1 binding	1/236	22/18367	0.247742459755155	0.479090197908866	SLC6A4	1
GO:0030742	GTP-dependent protein binding	1/236	22/18367	0.247742459755155	0.479090197908866	EEA1	1
GO:0050321	tau-protein kinase activity	1/236	22/18367	0.247742459755155	0.479090197908866	TAOK1	1
GO:0055106	ubiquitin-protein transferase regulator activity	1/236	22/18367	0.247742459755155	0.479090197908866	RPS15	1
GO:0070034	telomerase RNA binding	1/236	22/18367	0.247742459755155	0.479090197908866	DHX36	1
GO:0072349	modified amino acid transmembrane transporter activity	1/236	22/18367	0.247742459755155	0.479090197908866	SLC19A1	1
GO:0120020	cholesterol transfer activity	1/236	22/18367	0.247742459755155	0.479090197908866	APOE	1
GO:0015085	calcium ion transmembrane transporter activity	3/236	135/18367	0.25120875493489	0.483581683438346	ITGAV/ATP2B1/ATP2B4	3
GO:0005158	insulin receptor binding	1/236	23/18367	0.25741990753372	0.483581683438346	IGF1R	1
GO:0017134	fibroblast growth factor binding	1/236	23/18367	0.25741990753372	0.483581683438346	ITGAV	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/236	23/18367	0.25741990753372	0.483581683438346	LPCAT3	1
GO:0070412	R-SMAD binding	1/236	23/18367	0.25741990753372	0.483581683438346	TRIM33	1
GO:0071617	lysophospholipid acyltransferase activity	1/236	23/18367	0.25741990753372	0.483581683438346	LPCAT3	1
GO:0120015	sterol transfer activity	1/236	23/18367	0.25741990753372	0.483581683438346	APOE	1
GO:1901567	fatty acid derivative binding	1/236	23/18367	0.25741990753372	0.483581683438346	HADHA	1
GO:0099106	ion channel regulator activity	3/236	139/18367	0.26503200271	0.492729817414641	ATP2B4/PRSS8/AKAP9	3
GO:0003707	steroid hormone receptor activity	1/236	24/18367	0.266973380158123	0.492729817414641	ESRRG	1
GO:0015145	monosaccharide transmembrane transporter activity	1/236	24/18367	0.266973380158123	0.492729817414641	SLC2A1	1
GO:0043495	protein-membrane adaptor activity	1/236	24/18367	0.266973380158123	0.492729817414641	SYNE2	1
GO:0050431	transforming growth factor beta binding	1/236	24/18367	0.266973380158123	0.492729817414641	ITGAV	1
GO:0016835	carbon-oxygen lyase activity	2/236	79/18367	0.269821214414312	0.494515535825533	HACD3/HADHA	2
GO:0046332	SMAD binding	2/236	79/18367	0.269821214414312	0.494515535825533	TRIM33/CTNNB1	2
GO:0070851	growth factor receptor binding	3/236	141/18367	0.271978952795302	0.494519542593528	APP/IL6ST/EFEMP1	3
GO:0016887	ATP hydrolysis activity	5/236	272/18367	0.27224419789218	0.494519542593528	ATP2B1/ATP10D/ATP2B4/ATP13A3/DHX36	5
GO:0005112	Notch binding	1/236	25/18367	0.276404459168246	0.494519542593528	GALNT11	1
GO:0005227	calcium activated cation channel activity	1/236	25/18367	0.276404459168246	0.494519542593528	ANO6	1
GO:0030247	polysaccharide binding	1/236	25/18367	0.276404459168246	0.494519542593528	AGL	1
GO:0034237	protein kinase A regulatory subunit binding	1/236	25/18367	0.276404459168246	0.494519542593528	AKAP9	1
GO:0120227	acyl-CoA binding	1/236	25/18367	0.276404459168246	0.494519542593528	HADHA	1
GO:0015293	symporter activity	3/236	144/18367	0.282435551864685	0.49877935168344	SLC6A4/SLC13A4/SLC38A1	3
GO:0016922	nuclear receptor binding	3/236	144/18367	0.282435551864685	0.49877935168344	CALR/CTNNB1/MED13	3
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/236	26/18367	0.285714706013535	0.49877935168344	ZDHHC17	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/236	26/18367	0.285714706013535	0.49877935168344	ZDHHC17	1
GO:0038187	pattern recognition receptor activity	1/236	26/18367	0.285714706013535	0.49877935168344	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/236	26/18367	0.285714706013535	0.49877935168344	SLC26A2	1
GO:0016247	channel regulator activity	3/236	145/18367	0.285929347442764	0.49877935168344	ATP2B4/PRSS8/AKAP9	3
GO:0052689	carboxylic ester hydrolase activity	3/236	147/18367	0.292927300006826	0.49877935168344	IARS2/PON2/NOTUM	3
GO:0015171	amino acid transmembrane transporter activity	2/236	84/18367	0.293634233449197	0.49877935168344	SLC38A1/SLC38A9	2
GO:0004190	aspartic-type endopeptidase activity	1/236	27/18367	0.294905662307129	0.49877935168344	SPPL2A	1
GO:0015215	nucleotide transmembrane transporter activity	1/236	27/18367	0.294905662307129	0.49877935168344	SLC19A1	1
GO:0016405	CoA-ligase activity	1/236	27/18367	0.294905662307129	0.49877935168344	SLC27A2	1
GO:0023026	MHC class II protein complex binding	1/236	27/18367	0.294905662307129	0.49877935168344	B2M	1
GO:0035255	ionotropic glutamate receptor binding	1/236	27/18367	0.294905662307129	0.49877935168344	CANX	1
GO:0051119	sugar transmembrane transporter activity	1/236	27/18367	0.294905662307129	0.49877935168344	SLC2A1	1
GO:0051393	alpha-actinin binding	1/236	27/18367	0.294905662307129	0.49877935168344	DAG1	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/236	27/18367	0.294905662307129	0.49877935168344	ATP10D	1
GO:0019842	vitamin binding	3/236	148/18367	0.296430792280589	0.49975191262689	GLDC/SLC19A1/FOLR1	3
GO:0140677	molecular function activator activity	3/236	150/18367	0.303445174608763	0.502653724112149	APOE/PSAP/GM2A	3
GO:0003785	actin monomer binding	1/236	28/18367	0.303978850076786	0.502653724112149	TMSB10	1
GO:0004629	phospholipase C activity	1/236	28/18367	0.303978850076786	0.502653724112149	NOTUM	1
GO:0050681	androgen receptor binding	1/236	28/18367	0.303978850076786	0.502653724112149	CALR	1
GO:0051861	glycolipid binding	1/236	28/18367	0.303978850076786	0.502653724112149	PSAP	1
GO:0070001	aspartic-type peptidase activity	1/236	28/18367	0.303978850076786	0.502653724112149	SPPL2A	1
GO:0051015	actin filament binding	4/236	217/18367	0.304841326980562	0.502653724112149	EGFR/SLC6A4/UTRN/SYNE2	4
GO:0005506	iron ion binding	3/236	151/18367	0.306955422072514	0.504494927220224	HBA1/HBA2/CALR	3
GO:0005253	anion channel activity	2/236	87/18367	0.307876181820707	0.504494927220224	ANO6/CLDN4	2
GO:0015081	sodium ion transmembrane transporter activity	3/236	152/18367	0.310467284864881	0.504920908216736	SLC6A4/SLC13A4/SLC38A1	3
GO:0048306	calcium-dependent protein binding	2/236	88/18367	0.312611817351758	0.504920908216736	ATP2B4/S100A11	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/236	29/18367	0.312935772012654	0.504920908216736	CDK6	1
GO:0046625	sphingolipid binding	1/236	29/18367	0.312935772012654	0.504920908216736	PSAP	1
GO:0097472	cyclin-dependent protein kinase activity	1/236	29/18367	0.312935772012654	0.504920908216736	CDK6	1
GO:0015297	antiporter activity	2/236	89/18367	0.317340565056013	0.508905906156899	SLC26A2/SLC19A1	2
GO:0051117	ATPase binding	2/236	89/18367	0.317340565056013	0.508905906156899	EGFR/USP25	2
GO:0005343	organic acid:sodium symporter activity	1/236	30/18367	0.321777911711913	0.509804763736344	SLC38A1	1
GO:0016417	S-acyltransferase activity	1/236	30/18367	0.321777911711913	0.509804763736344	ZDHHC17	1
GO:0017147	Wnt-protein binding	1/236	30/18367	0.321777911711913	0.509804763736344	WLS	1
GO:0046966	thyroid hormone receptor binding	1/236	30/18367	0.321777911711913	0.509804763736344	MED13	1
GO:0016411	acylglycerol O-acyltransferase activity	1/236	31/18367	0.330506733920344	0.518944901618211	LPCAT3	1
GO:0016878	acid-thiol ligase activity	1/236	31/18367	0.330506733920344	0.518944901618211	SLC27A2	1
GO:0031210	phosphatidylcholine binding	1/236	31/18367	0.330506733920344	0.518944901618211	SCARB2	1
GO:0016853	isomerase activity	3/236	158/18367	0.331555173488742	0.519041729925828	P4HB/NKTR/PDIA4	3
GO:0031625	ubiquitin protein ligase binding	5/236	297/18367	0.334750560265181	0.522443522790693	EGFR/RPS27A/USP25/CALR/UBXN7	5
GO:0015605	organophosphate ester transmembrane transporter activity	1/236	32/18367	0.339123684770846	0.522443522790693	SLC19A1	1
GO:0030332	cyclin binding	1/236	32/18367	0.339123684770846	0.522443522790693	CDK6	1
GO:0071889	14-3-3 protein binding	1/236	32/18367	0.339123684770846	0.522443522790693	ZFP36L1	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/236	32/18367	0.339123684770846	0.522443522790693	SMARCA2	1
GO:0140097	catalytic activity, acting on DNA	4/236	229/18367	0.339687613677599	0.522443522790693	DHX36/DNMT3A/BPTF/SMARCA2	4
GO:0008083	growth factor activity	3/236	162/18367	0.345607969302342	0.528478268791821	GRN/EFEMP1/CSH1	3
GO:0005154	epidermal growth factor receptor binding	1/236	33/18367	0.347630192018954	0.528478268791821	EFEMP1	1
GO:0031369	translation initiation factor binding	1/236	33/18367	0.347630192018954	0.528478268791821	RPS24	1
GO:0051427	hormone receptor binding	1/236	33/18367	0.347630192018954	0.528478268791821	CSH1	1
GO:0004896	cytokine receptor activity	2/236	97/18367	0.354853600952457	0.533534335996742	CSF3R/IL6ST	2
GO:0015020	glucuronosyltransferase activity	1/236	34/18367	0.356027665275392	0.533534335996742	CHPF	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/236	34/18367	0.356027665275392	0.533534335996742	CDKN1C	1
GO:0035198	miRNA binding	1/236	34/18367	0.356027665275392	0.533534335996742	NEAT1	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/236	34/18367	0.356027665275392	0.533534335996742	IGF1R	1
GO:0042887	amide transmembrane transporter activity	1/236	35/18367	0.364317496235683	0.544406258579458	SLC19A1	1
GO:0005496	steroid binding	2/236	100/18367	0.368741106765505	0.548545501385078	ESRRG/SCARB2	2
GO:0015248	sterol transporter activity	1/236	36/18367	0.37250105890688	0.548545501385078	APOE	1
GO:0023023	MHC protein complex binding	1/236	36/18367	0.37250105890688	0.548545501385078	B2M	1
GO:0042805	actinin binding	1/236	36/18367	0.37250105890688	0.548545501385078	DAG1	1
GO:0061631	ubiquitin conjugating enzyme activity	1/236	36/18367	0.37250105890688	0.548545501385078	BIRC6	1
GO:0030295	protein kinase activator activity	2/236	101/18367	0.373344656836232	0.548545501385078	RPLP1/TAOK1	2
GO:0005109	frizzled binding	1/236	37/18367	0.380579709831432	0.552997036937385	DVL3	1
GO:0016409	palmitoyltransferase activity	1/236	37/18367	0.380579709831432	0.552997036937385	ZDHHC17	1
GO:0030551	cyclic nucleotide binding	1/236	37/18367	0.380579709831432	0.552997036937385	SLC19A1	1
GO:0046915	transition metal ion transmembrane transporter activity	1/236	37/18367	0.380579709831432	0.552997036937385	SLC40A1	1
GO:0044389	ubiquitin-like protein ligase binding	5/236	316/18367	0.383097238201528	0.554034362603364	EGFR/RPS27A/USP25/CALR/UBXN7	5
GO:0042393	histone binding	4/236	244/18367	0.383400205299666	0.554034362603364	TBL1X/CTSL/BPTF/SMARCA2	4
GO:0004252	serine-type endopeptidase activity	3/236	174/18367	0.387545249412463	0.558414805055003	DPP4/PRSS8/CTSC	3
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/236	38/18367	0.388554788308234	0.558414805055003	NKTR	1
GO:0050997	quaternary ammonium group binding	1/236	39/18367	0.396427616610883	0.5666329520036	SCARB2	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/236	39/18367	0.396427616610883	0.5666329520036	BIRC6	1
GO:0019209	kinase activator activity	2/236	107/18367	0.40066786630892	0.571141728125994	RPLP1/TAOK1	2
GO:0004177	aminopeptidase activity	1/236	40/18367	0.404199500203192	0.571529400824943	DPP4	1
GO:0015144	carbohydrate transmembrane transporter activity	1/236	40/18367	0.404199500203192	0.571529400824943	SLC2A1	1
GO:0044183	protein folding chaperone	1/236	40/18367	0.404199500203192	0.571529400824943	CALR	1
GO:0004812	aminoacyl-tRNA ligase activity	1/236	41/18367	0.411871727951981	0.574653922818944	IARS2	1
GO:0016859	cis-trans isomerase activity	1/236	41/18367	0.411871727951981	0.574653922818944	NKTR	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/236	41/18367	0.411871727951981	0.574653922818944	IARS2	1
GO:0016877	ligase activity, forming carbon-sulfur bonds	1/236	41/18367	0.411871727951981	0.574653922818944	SLC27A2	1
GO:0030331	estrogen receptor binding	1/236	41/18367	0.411871727951981	0.574653922818944	CTNNB1	1
GO:0004222	metalloendopeptidase activity	2/236	111/18367	0.418572151083523	0.582132905143434	ADAMTS6/MME	2
GO:0019205	nucleobase-containing compound kinase activity	1/236	42/18367	0.419445572337189	0.582132905143434	N4BP2	1
GO:0022839	ion gated channel activity	1/236	44/18367	0.434303120244387	0.60107289802858	ANO6	1
GO:0003713	transcription coactivator activity	4/236	262/18367	0.435377897621462	0.60107289802858	PAGE4/CTNNB1/MED13/SMARCA2	4
GO:0005245	voltage-gated calcium channel activity	1/236	45/18367	0.441589288645977	0.607541520404648	ITGAV	1
GO:0008237	metallopeptidase activity	3/236	190/18367	0.442373388431522	0.607541520404648	ADAMTS6/MME/TFRC	3
GO:0008236	serine-type peptidase activity	3/236	191/18367	0.445741600143911	0.610573129363795	DPP4/PRSS8/CTSC	3
GO:0004864	protein phosphatase inhibitor activity	1/236	46/18367	0.448782003845166	0.611552678814915	PHACTR2	1
GO:0061980	regulatory RNA binding	1/236	46/18367	0.448782003845166	0.611552678814915	NEAT1	1
GO:0035254	glutamate receptor binding	1/236	47/18367	0.455882459447619	0.618026220797545	CANX	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/236	47/18367	0.455882459447619	0.618026220797545	ADRB1	1
GO:0017171	serine hydrolase activity	3/236	195/18367	0.459132862337447	0.620832610769915	DPP4/PRSS8/CTSC	3
GO:0016829	lyase activity	3/236	196/18367	0.462459464994852	0.622713822557529	GLDC/HACD3/HADHA	3
GO:0120013	lipid transfer activity	1/236	48/18367	0.462891833878315	0.622713822557529	APOE	1
GO:0019212	phosphatase inhibitor activity	1/236	49/18367	0.469811290573808	0.626784201296244	PHACTR2	1
GO:0043539	protein serine/threonine kinase activator activity	1/236	49/18367	0.469811290573808	0.626784201296244	TAOK1	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/236	124/18367	0.474783090977721	0.626784201296244	LDHA/HADHA	2
GO:0015485	cholesterol binding	1/236	50/18367	0.476641978172049	0.626784201296244	SCARB2	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/236	50/18367	0.476641978172049	0.626784201296244	SLC19A1	1
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/236	50/18367	0.476641978172049	0.626784201296244	CDKN1C	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/236	50/18367	0.476641978172049	0.626784201296244	MAN2A1	1
GO:0030159	signaling receptor complex adaptor activity	1/236	50/18367	0.476641978172049	0.626784201296244	DLG5	1
GO:0140359	ABC-type transporter activity	1/236	50/18367	0.476641978172049	0.626784201296244	ATP13A3	1
GO:0003730	mRNA 3'-UTR binding	3/236	201/18367	0.47895746995368	0.628258426921784	ZFP36L1/DHX36/RPL41	3
GO:0008227	G protein-coupled amine receptor activity	1/236	51/18367	0.483385030699832	0.630919419722361	ADRB1	1
GO:0051018	protein kinase A binding	1/236	51/18367	0.483385030699832	0.630919419722361	AKAP9	1
GO:0019887	protein kinase regulator activity	3/236	204/18367	0.488743062832361	0.631769276079985	RPLP1/CDKN1C/TAOK1	3
GO:0004879	nuclear receptor activity	1/236	52/18367	0.490041567757859	0.631769276079985	ESRRG	1
GO:0016597	amino acid binding	1/236	52/18367	0.490041567757859	0.631769276079985	GLDC	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/236	52/18367	0.490041567757859	0.631769276079985	AGL	1
GO:0098531	ligand-activated transcription factor activity	1/236	52/18367	0.490041567757859	0.631769276079985	ESRRG	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/236	53/18367	0.496612694703486	0.637117749790326	SLC19A1	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/236	53/18367	0.496612694703486	0.637117749790326	SLC6A4	1
GO:0008374	O-acyltransferase activity	1/236	54/18367	0.503099502831146	0.640751424913276	LPCAT3	1
GO:0015459	potassium channel regulator activity	1/236	54/18367	0.503099502831146	0.640751424913276	AKAP9	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/236	54/18367	0.503099502831146	0.640751424913276	P4HB	1
GO:0030170	pyridoxal phosphate binding	1/236	55/18367	0.509503069550518	0.647339648752591	GLDC	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	1/236	56/18367	0.515824458562427	0.65065627147203	BIRC6	1
GO:0030374	nuclear receptor coactivator activity	1/236	56/18367	0.515824458562427	0.65065627147203	MED13	1
GO:0070279	vitamin B6 binding	1/236	56/18367	0.515824458562427	0.65065627147203	GLDC	1
GO:0005548	phospholipid transporter activity	1/236	57/18367	0.522064720032541	0.656952255351954	ANO6	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	2/236	136/18367	0.523664150401346	0.657392226995484	LDHA/HADHA	2
GO:0001664	G protein-coupled receptor binding	4/236	295/18367	0.52691643433777	0.659900105861112	WLS/ADRB1/ITGB4/DVL3	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/236	58/18367	0.52822489076287	0.659967440715605	SLC27A2	1
GO:0015631	tubulin binding	5/236	375/18367	0.529569494733915	0.660079512393459	DAG1/DST/CLIP1/TAOK1/EML4	5
GO:0036002	pre-mRNA binding	1/236	59/18367	0.534305994361099	0.664408872420657	SF1	1
GO:0045182	translation regulator activity	2/236	140/18367	0.539268832347917	0.668711895954109	RPS14/RPL10	2
GO:0032934	sterol binding	1/236	60/18367	0.540309041407788	0.668711895954109	SCARB2	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	3/236	222/18367	0.545469276545058	0.673513707658921	LPCAT3/ZDHHC17/HADHA	3
GO:0005096	GTPase activator activity	6/236	462/18367	0.54694220418505	0.673750818270108	NRP1/ADRB1/HACD3/ARHGAP5/MYCBP2/EPS8L2	6
GO:0005085	guanyl-nucleotide exchange factor activity	3/236	223/18367	0.548513460750534	0.674107664380329	ADRB1/MYCBP2/EPS8L2	3
GO:0098960	postsynaptic neurotransmitter receptor activity	1/236	62/18367	0.552084944021624	0.676915339289916	ADRB1	1
GO:0140375	immune receptor activity	2/236	144/18367	0.554518615195145	0.677708821487925	CSF3R/IL6ST	2
GO:0004674	protein serine/threonine kinase activity	5/236	386/18367	0.555308939280029	0.677708821487925	EGFR/MAP3K1/CDK6/TAOK1/SLK	5
GO:0008528	G protein-coupled peptide receptor activity	2/236	147/18367	0.565720587305769	0.688817196580635	LGR5/LGR4	2
GO:0002039	p53 binding	1/236	66/18367	0.574743128367549	0.698186802589679	MDM4	1
GO:0019207	kinase regulator activity	3/236	233/18367	0.578288912006529	0.700875501648466	RPLP1/CDKN1C/TAOK1	3
GO:0005125	cytokine activity	3/236	235/18367	0.584095136994864	0.706285154159307	SPP1/GRN/FAM3B	3
GO:0001653	peptide receptor activity	2/236	153/18367	0.587514348442036	0.708790246056217	LGR5/LGR4	2
GO:0004857	enzyme inhibitor activity	1/236	70/18367	0.59625973921162	0.716056216496146	RPS15	1
GO:0004860	protein kinase inhibitor activity	1/236	70/18367	0.59625973921162	0.716056216496146	CDKN1C	1
GO:0004386	helicase activity	2/236	156/18367	0.598104844390933	0.716337247639217	DHX36/SMARCA2	2
GO:0030695	GTPase regulator activity	6/236	488/18367	0.600579327393336	0.716337247639217	NRP1/ADRB1/HACD3/ARHGAP5/MYCBP2/EPS8L2	6
GO:0060589	nucleoside-triphosphatase regulator activity	6/236	488/18367	0.600579327393336	0.716337247639217	NRP1/ADRB1/HACD3/ARHGAP5/MYCBP2/EPS8L2	6
GO:0003678	DNA helicase activity	1/236	72/18367	0.606607968971134	0.716844671738046	DHX36	1
GO:0008235	metalloexopeptidase activity	1/236	72/18367	0.606607968971134	0.716844671738046	TFRC	1
GO:0030276	clathrin binding	1/236	72/18367	0.606607968971134	0.716844671738046	LRP1	1
GO:0046982	protein heterodimerization activity	4/236	328/18367	0.61073770711508	0.716844671738046	TENM3/ADRB1/P4HB/ITGB1	4
GO:0033293	monocarboxylic acid binding	1/236	73/18367	0.611682607906516	0.716844671738046	PSAP	1
GO:0035064	methylated histone binding	1/236	73/18367	0.611682607906516	0.716844671738046	BPTF	1
GO:0140034	methylation-dependent protein binding	1/236	73/18367	0.611682607906516	0.716844671738046	BPTF	1
GO:0140030	modification-dependent protein binding	2/236	160/18367	0.611907333860043	0.716844671738046	AGL/BPTF	2
GO:0019210	kinase inhibitor activity	1/236	74/18367	0.616692059340541	0.719246171204267	CDKN1C	1
GO:0019905	syntaxin binding	1/236	74/18367	0.616692059340541	0.719246171204267	SLC6A4	1
GO:0016746	acyltransferase activity	3/236	250/18367	0.626000728342112	0.728487573247679	LPCAT3/ZDHHC17/HADHA	3
GO:0016874	ligase activity	2/236	165/18367	0.628649966261096	0.729955589963215	IARS2/SLC27A2	2
GO:0003724	RNA helicase activity	1/236	77/18367	0.631337574301833	0.731461594895956	DHX36	1
GO:0001221	transcription coregulator binding	1/236	78/18367	0.636094508826971	0.735353212402168	CTNNB1	1
GO:0008186	ATP-dependent activity, acting on RNA	1/236	79/18367	0.6407903202938	0.73915725542662	DHX36	1
GO:0031267	small GTPase binding	3/236	259/18367	0.649721904719363	0.746508493929884	DIAPH2/MYCBP2/DVL3	3
GO:0035591	signaling adaptor activity	1/236	81/18367	0.650001692433245	0.746508493929884	DLG5	1
GO:0008017	microtubule binding	3/236	271/18367	0.679663557844791	0.774355585196377	DST/CLIP1/EML4	3
GO:0008276	protein methyltransferase activity	1/236	88/18367	0.680427899420157	0.774355585196377	DNMT3A	1
GO:0051219	phosphoprotein binding	1/236	88/18367	0.680427899420157	0.774355585196377	PRKCSH	1
GO:0106310	protein serine kinase activity	4/236	360/18367	0.68275628600105	0.774355585196377	MAP3K1/CDK6/TAOK1/SLK	4
GO:0008081	phosphoric diester hydrolase activity	1/236	89/18367	0.684553891856113	0.774355585196377	NOTUM	1
GO:0019888	protein phosphatase regulator activity	1/236	89/18367	0.684553891856113	0.774355585196377	PHACTR2	1
GO:0043178	alcohol binding	1/236	89/18367	0.684553891856113	0.774355585196377	SCARB2	1
GO:0016407	acetyltransferase activity	1/236	91/18367	0.692647412410478	0.781829482677921	HADHA	1
GO:0051213	dioxygenase activity	1/236	92/18367	0.696616290210386	0.784625628802276	P4HB	1
GO:0005543	phospholipid binding	5/236	466/18367	0.71844604843652	0.807484233926516	APOE/MME/SCARB2/EEA1/PSAP	5
GO:0051020	GTPase binding	3/236	291/18367	0.725291229716052	0.813439630768962	DIAPH2/MYCBP2/DVL3	3
GO:0005244	voltage-gated ion channel activity	2/236	201/18367	0.732938093137687	0.81753238808831	ITGAV/ANO6	2
GO:0022832	voltage-gated channel activity	2/236	201/18367	0.732938093137687	0.81753238808831	ITGAV/ANO6	2
GO:0004725	protein tyrosine phosphatase activity	1/236	102/18367	0.733603207562133	0.81753238808831	PTPRF	1
GO:0005200	structural constituent of cytoskeleton	1/236	103/18367	0.737045290398998	0.819631760570556	KRT19	1
GO:0004620	phospholipase activity	1/236	104/18367	0.740443084500282	0.821673127525629	NOTUM	1
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	3/236	299/18367	0.742069951352611	0.821744830339944	CALR/CTNNB1/MED13	3
GO:1990782	protein tyrosine kinase binding	1/236	105/18367	0.743797157328291	0.821927110829162	ITGB1	1
GO:0140297	DNA-binding transcription factor binding	4/236	394/18367	0.74852058092161	0.825412632211251	CALR/CTNNB1/MED13/TLE4	4
GO:0019208	phosphatase regulator activity	1/236	107/18367	0.750376372905199	0.825727975205302	PHACTR2	1
GO:0000149	SNARE binding	1/236	110/18367	0.759931061861543	0.834496322628751	SLC6A4	1
GO:0030594	neurotransmitter receptor activity	1/236	111/18367	0.763034324686798	0.835262525378704	ADRB1	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	3/236	310/18367	0.763804704766458	0.835262525378704	PEG3/NFE2L3/ZFHX3	3
GO:0004843	thiol-dependent deubiquitinase	1/236	113/18367	0.76912152232162	0.837972845904798	USP25	1
GO:0001217	DNA-binding transcription repressor activity	3/236	313/18367	0.769469362304215	0.837972845904798	PEG3/NFE2L3/ZFHX3	3
GO:0101005	deubiquitinase activity	1/236	114/18367	0.772106474700939	0.839107449778293	USP25	1
GO:0000287	magnesium ion binding	2/236	221/18367	0.779397029872249	0.845284201469696	ATP10D/DHX36	2
GO:0005262	calcium channel activity	1/236	119/18367	0.786464545750322	0.851194137993147	ITGAV	1
GO:0003697	single-stranded DNA binding	1/236	123/18367	0.797299515819038	0.860780800096098	DHX36	1
GO:0140101	catalytic activity, acting on a tRNA	1/236	124/18367	0.799921600573845	0.860780800096098	IARS2	1
GO:0019783	ubiquitin-like protein-specific protease activity	1/236	125/18367	0.802509908542083	0.860780800096098	USP25	1
GO:0008242	omega peptidase activity	1/236	126/18367	0.805064872996862	0.860780800096098	USP25	1
GO:0009055	electron transfer activity	1/236	126/18367	0.805064872996862	0.860780800096098	GLDC	1
GO:0042826	histone deacetylase binding	1/236	127/18367	0.807586921676909	0.860780800096098	DHX36	1
GO:0140678	molecular function inhibitor activity	1/236	128/18367	0.810076476856967	0.860780800096098	RPS15	1
GO:0004842	ubiquitin-protein transferase activity	4/236	433/18367	0.810579881841322	0.860780800096098	TRIM33/BIRC6/UBR4/MYCBP2	4
GO:0004519	endonuclease activity	1/236	129/18367	0.812533955417291	0.860780800096098	N4BP2	1
GO:0016298	lipase activity	1/236	129/18367	0.812533955417291	0.860780800096098	NOTUM	1
GO:0015078	proton transmembrane transporter activity	1/236	130/18367	0.814959768912275	0.860780800096098	ATP6V1B1	1
GO:0017124	SH3 domain binding	1/236	130/18367	0.814959768912275	0.860780800096098	LRP2	1
GO:0019787	ubiquitin-like protein transferase activity	4/236	458/18367	0.843396342492675	0.887668969829308	TRIM33/BIRC6/UBR4/MYCBP2	4
GO:0022843	voltage-gated cation channel activity	1/236	143/18367	0.843791796415692	0.887668969829308	ITGAV	1
GO:0042578	phosphoric ester hydrolase activity	3/236	366/18367	0.852430668983397	0.894967129511511	PTPRF/PLPP3/NOTUM	3
GO:0060090	molecular adaptor activity	3/236	369/18367	0.856239725204722	0.897175488959529	SYNE2/AKAP9/DLG5	3
GO:0005126	cytokine receptor binding	2/236	271/18367	0.865877272757722	0.905470070518015	IL6ST/CSH1	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/236	156/18367	0.868147406241265	0.906042729529575	DNMT3A	1
GO:0016791	phosphatase activity	2/236	275/18367	0.871247876609899	0.90747798633031	PTPRF/PLPP3	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/236	170/18367	0.890162247922615	0.925346526496631	P4HB	1
GO:0004721	phosphoprotein phosphatase activity	1/236	174/18367	0.895750825316765	0.928101968874707	PTPRF	1
GO:0030674	protein-macromolecule adaptor activity	2/236	296/18367	0.896341825453139	0.928101968874707	SYNE2/DLG5	2
GO:0061630	ubiquitin protein ligase activity	2/236	304/18367	0.904648131808001	0.934862313027522	UBR4/MYCBP2	2
GO:0061659	ubiquitin-like protein ligase activity	2/236	316/18367	0.915952790443517	0.944688564261353	UBR4/MYCBP2	2
GO:0005216	ion channel activity	3/236	432/18367	0.918567661244688	0.945531486917233	ITGAV/ANO6/CLDN4	3
GO:0005261	cation channel activity	2/236	335/18367	0.931319182163059	0.956726053092806	ITGAV/ANO6	2
GO:0004518	nuclease activity	1/236	210/18367	0.93487685163985	0.956726053092806	N4BP2	1
GO:0022836	gated channel activity	2/236	340/18367	0.934899603212362	0.956726053092806	ITGAV/ANO6	2
GO:0008168	methyltransferase activity	1/236	214/18367	0.938197494332225	0.958236664114079	DNMT3A	1
GO:0016741	transferase activity, transferring one-carbon groups	1/236	225/18367	0.946485128007514	0.963467690490655	DNMT3A	1
GO:0015267	channel activity	3/236	480/18367	0.948317970367578	0.963467690490655	ITGAV/ANO6/CLDN4	3
GO:0022803	passive transmembrane transporter activity	3/236	481/18367	0.948814189494599	0.963467690490655	ITGAV/ANO6/CLDN4	3
GO:0140098	catalytic activity, acting on RNA	2/236	386/18367	0.960504946987302	0.973459734326244	IARS2/DHX36	2
GO:0019001	guanyl nucleotide binding	2/236	398/18367	0.965400477519878	0.974665357342525	SLC19A1/ARHGAP5	2
GO:0032561	guanyl ribonucleotide binding	2/236	398/18367	0.965400477519878	0.974665357342525	SLC19A1/ARHGAP5	2
GO:0035091	phosphatidylinositol binding	1/236	271/18367	0.970720436690733	0.978158907469972	EEA1	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	2/236	450/18367	0.980660164663934	0.985677762813122	CREB3L2/ESRRG	2
GO:0001216	DNA-binding transcription activator activity	2/236	456/18367	0.981929938619917	0.985677762813122	CREB3L2/ESRRG	2
GO:0003924	GTPase activity	1/236	337/18367	0.987708414045985	0.989589763406073	ARHGAP5	1
GO:0005525	GTP binding	1/236	377/18367	0.992747750260921	0.992747750260921	ARHGAP5	1