ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	23/313	182/18367	7.1381080646254e-14	3.75464484199296e-11	RPL39/RPS29/ISG15/RPL37A/RPLP2/RPS28/RPL36/RPS12/RPLP1/RPS10/RPL36A/RPS27/RPL3/RPL12/RPL17/RPL37/RPS27L/RPL18A/UBA52/RPS15/RPL34/RPS15A/RPS26	23
GO:0044389	ubiquitin-like protein ligase binding	27/313	316/18367	6.38921544267576e-12	1.68036366142373e-09	NFKBIA/JUN/ISG15/CEBPB/UBC/HSPA1A/UBE2B/GABARAPL2/RALA/UBE2L6/CACYBP/CXCR4/HSP90AB1/MAP1LC3B/BID/EGFR/TRIB1/STAT1/SUMO2/HSPA1B/DNAJA1/HSP90AA1/LAPTM5/UBA52/TUBA1B/UBB/TXNIP	27
GO:0031625	ubiquitin protein ligase binding	25/313	297/18367	5.50116259330739e-11	9.64537174693229e-09	NFKBIA/JUN/ISG15/UBC/HSPA1A/UBE2B/GABARAPL2/RALA/UBE2L6/CACYBP/CXCR4/HSP90AB1/MAP1LC3B/BID/EGFR/TRIB1/SUMO2/HSPA1B/DNAJA1/HSP90AA1/LAPTM5/UBA52/TUBA1B/UBB/TXNIP	25
GO:0042605	peptide antigen binding	10/313	36/18367	3.07361364961153e-10	4.04180194923917e-08	HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HLA-DPA1	10
GO:0023026	MHC class II protein complex binding	9/313	27/18367	3.86900416940857e-10	4.07019238621781e-08	B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HSP90AB1/HLA-DPA1/HSP90AA1	9
GO:0023023	MHC protein complex binding	9/313	36/18367	6.79138386225522e-09	5.95377985257708e-07	B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HSP90AB1/HLA-DPA1/HSP90AA1	9
GO:0032395	MHC class II receptor activity	5/313	10/18367	3.27099766551843e-07	2.4579211029467e-05	HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DQB1/HLA-DPA1	5
GO:0031386	protein tag	5/313	13/18367	1.60161432758712e-06	0.000105306142038853	ISG15/UBC/SUMO2/UBA52/UBB	5
GO:0042379	chemokine receptor binding	9/313	72/18367	3.58577785800882e-06	0.000209568794812515	CCL3/CCL3L3/CCL4/CXCL8/STAT1/CXCL2/CXCL3/DEFB1/CXCL10	9
GO:0003725	double-stranded RNA binding	9/313	74/18367	4.51958799163184e-06	0.000237730328359835	OAS1/OAS2/IFIH1/EIF2AK2/HSP90AB1/OAS3/HMGB1/HNRNPU/TUBA1B	9
GO:0140297	DNA-binding transcription factor binding	20/313	394/18367	1.52210390730417e-05	0.000702366542092246	JUND/NFKBIA/JUN/FOS/YWHAH/KLF4/CEBPB/LMO2/PTMA/SRI/CREM/IFI27/BHLHE41/STAT1/NR4A2/NPM1/HMGB1/DNAJA1/DDX5/HES1	20
GO:0050786	RAGE receptor binding	4/313	10/18367	1.60235713024847e-05	0.000702366542092246	HMGB2/S100A8/HMGB1/S100A9	4
GO:0008009	chemokine activity	7/313	49/18367	1.81472847356649e-05	0.000734267059304593	CCL3/CCL3L3/CCL4/CXCL8/CXCL2/CXCL3/CXCL10	7
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	16/313	299/18367	5.85017068814566e-05	0.0021979927014033	JUND/NFKBIA/JUN/FOS/YWHAH/KLF4/CEBPB/LMO2/IFI27/BHLHE41/STAT1/NR4A2/NPM1/DNAJA1/DDX5/HES1	16
GO:0042826	histone deacetylase binding	10/313	127/18367	6.44501825073391e-05	0.00223646079676099	KLF4/CEBPB/HSPA1A/BEX4/HSP90AB1/BHLHE41/HSPA1B/RAC1/HSP90AA1/HES1	10
GO:0005126	cytokine receptor binding	15/313	271/18367	6.80292257569883e-05	0.00223646079676099	CCL3/CCL3L3/CCL4/CXCL8/IL1B/GRB2/BID/TNFSF13B/STAT1/SDCBP/CXCL2/TNFSF10/CXCL3/DEFB1/CXCL10	15
GO:0016504	peptidase activator activity	6/313	43/18367	8.36935264264015e-05	0.00258957617060513	FBLN1/CASP1/PSME2/FN1/CTSH/RPS27L	6
GO:0016209	antioxidant activity	8/313	86/18367	0.000108970846481189	0.00318437029161696	SOD2/PRDX3/GLRX/HBA2/APOE/HBA1/S100A9/PRDX1	8
GO:0048306	calcium-dependent protein binding	8/313	88/18367	0.000128184437575288	0.00354868495603166	VAMP2/S100A8/DDX5/CALM1/S100A9/ANXA1/S100A6/S100P	8
GO:0003823	antigen binding	11/313	171/18367	0.000173740174097883	0.00436245683035241	HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/CD48/HLA-F/HLA-DPA1	11
GO:0001664	G protein-coupled receptor binding	15/313	295/18367	0.00017416652744753	0.00436245683035241	CCL3/CCL3L3/HSPA1A/CCL4/CXCL8/RALA/STAT1/SDCBP/HSPA1B/CXCL2/DNAJA1/CXCL3/DEFB1/CALM1/CXCL10	15
GO:0045296	cadherin binding	16/313	332/18367	0.000196738975870349	0.00470385005944561	CHMP5/HSPA1A/SWAP70/HSP90AB1/PCMT1/EGFR/SNX2/STAT1/LDHA/EIF3E/ALDOA/RPL34/PRDX1/ANXA1/S100P/RPS26	16
GO:0045236	CXCR chemokine receptor binding	4/313	18/18367	0.000209609936740226	0.00479368811849386	CXCL8/CXCL2/CXCL3/CXCL10	4
GO:0051082	unfolded protein binding	9/313	122/18367	0.000244490796334403	0.005358423286329	HSPA1A/TTC1/PTGES3/HSP90AB1/HSPA1B/DNAJB6/NPM1/DNAJA1/HSP90AA1	9
GO:0097718	disordered domain specific binding	5/313	36/18367	0.000340173856088352	0.00715725793209892	HSPA1A/HSP90AB1/FN1/HSP90AA1/CALM1	5
GO:0031072	heat shock protein binding	9/313	129/18367	0.000370381170966795	0.00749309599725132	SNCA/HSPA1A/ZFP36/PTGES3/GBP1/HSP90AB1/HSPA1B/DNAJB6/DNAJA1	9
GO:0070182	DNA polymerase binding	4/313	22/18367	0.000474851044874762	0.00925080183718981	PTGES3/HSP90AB1/HMGB1/HSP90AA1	4
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	5/313	40/18367	0.000561628440030238	0.0105505914091395	SNCA/CASP1/PRDX3/CTSH/RPS27L	5
GO:0047485	protein N-terminus binding	8/313	110/18367	0.000591852197207606	0.0106984100001698	SNCA/HSPA1A/GLRX/SDCBP/HSPA1B/NPM1/EIF3E/CALM1	8
GO:0061134	peptidase regulator activity	12/313	230/18367	0.000610175475294854	0.0106984100001698	FBLN1/SNCA/CASP1/PRDX3/BST2/SERPINF1/PSME2/TIMP3/ITIH5/FN1/CTSH/RPS27L	12
GO:0045182	translation regulator activity	9/313	140/18367	0.000672786874462852	0.0114156740634665	EIF1B/PAIP2/ABCF1/EIF2AK2/EEF1A1/CIRBP/EIF4A2/EIF3E/RPS27L	9
GO:0042608	T cell receptor binding	3/313	11/18367	0.000730732581271295	0.0120114168046469	HLA-A/HLA-DRB1/HLA-DRA	3
GO:0005525	GTP binding	16/313	377/18367	0.000792161180038601	0.0126265691121304	IFI44L/MX1/RHOB/MX2/GBP4/RALA/GBP1/ARL5A/HSP90AB1/RAB8A/EEF1A1/GIMAP4/RAB2A/ARL4A/RAC1/TUBA1B	16
GO:0004857	enzyme inhibitor activity	6/313	70/18367	0.0012256826243126	0.0189620311878949	OAZ1/RPL37/RPS15/ANXA1/APOC1/TXNIP	6
GO:0042277	peptide binding	14/313	321/18367	0.00128456547993897	0.0191117170133629	HLA-C/NFKBIA/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HSP90AB1/HLA-DPA1/APOE/C1QA	14
GO:0048020	CCR chemokine receptor binding	5/313	48/18367	0.0013080262594697	0.0191117170133629	CCL3/CCL3L3/CCL4/STAT1/DEFB1	5
GO:0019001	guanyl nucleotide binding	16/313	398/18367	0.00139420578621734	0.0192987432513243	IFI44L/MX1/RHOB/MX2/GBP4/RALA/GBP1/ARL5A/HSP90AB1/RAB8A/EEF1A1/GIMAP4/RAB2A/ARL4A/RAC1/TUBA1B	16
GO:0032561	guanyl ribonucleotide binding	16/313	398/18367	0.00139420578621734	0.0192987432513243	IFI44L/MX1/RHOB/MX2/GBP4/RALA/GBP1/ARL5A/HSP90AB1/RAB8A/EEF1A1/GIMAP4/RAB2A/ARL4A/RAC1/TUBA1B	16
GO:0033218	amide binding	16/313	400/18367	0.00146768908461417	0.0197949861155654	HLA-C/NFKBIA/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/VDAC2/HLA-F/HSP90AB1/HLA-DPA1/MAP1LC3B/APOE/C1QA	16
GO:0004298	threonine-type endopeptidase activity	3/313	14/18367	0.00155202550171286	0.0198885433470801	PSMB10/PSMB8/PSMB9	3
GO:0035259	glucocorticoid receptor binding	3/313	14/18367	0.00155202550171286	0.0198885433470801	YWHAH/CEBPB/NR4A2	3
GO:0140678	molecular function inhibitor activity	8/313	128/18367	0.00158805859425354	0.0198885433470801	ENSA/OAZ1/RPL37/RPS15/CALM1/ANXA1/APOC1/TXNIP	8
GO:1990825	sequence-specific mRNA binding	3/313	15/18367	0.00191569259926298	0.0234338210979612	SRSF4/SSB/SRSF3	3
GO:0003924	GTPase activity	14/313	337/18367	0.00202097373814942	0.0241598224151499	MX1/RHOB/MX2/GBP4/RALA/RGS1/GBP1/ARL5A/RAB8A/EEF1A1/RAB2A/ARL4A/RAC1/TUBA1B	14
GO:0019207	kinase regulator activity	11/313	233/18367	0.00225852257423689	0.0263996194233024	KLF4/SNCA/HSP90AB1/RPLP1/TRIB1/SOCS3/NPM1/HMGB1/PKIB/CALM1/CXCL10	11
GO:0019208	phosphatase regulator activity	7/313	107/18367	0.00238007489954811	0.0270089617645562	PPP1R15A/ANP32E/ENSA/EIF2AK2/PHACTR1/SET/CALM1	7
GO:0005125	cytokine activity	11/313	235/18367	0.0024133482945516	0.0270089617645562	CCL3/CCL3L3/CCL4/CXCL8/IL1B/TNFSF13B/CXCL2/TNFSF10/HMGB1/CXCL3/CXCL10	11
GO:0090079	translation regulator activity, nucleic acid binding	7/313	108/18367	0.0025087396395531	0.0274916052167693	EIF1B/PAIP2/ABCF1/EEF1A1/EIF4A2/EIF3E/RPS27L	7
GO:0019887	protein kinase regulator activity	10/313	204/18367	0.00269573706215064	0.0289379121365558	SNCA/HSP90AB1/RPLP1/TRIB1/SOCS3/NPM1/HMGB1/PKIB/CALM1/CXCL10	10
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	3/313	17/18367	0.00279171639935277	0.0293688565211912	CASP1/CTSH/RPS27L	3
GO:0005178	integrin binding	8/313	144/18367	0.00331112263459697	0.0334932789576539	FBLN1/ISG15/IL1B/EGFR/HMGB1/FN1/CD9/FBN1	8
GO:0140375	immune receptor activity	8/313	144/18367	0.00331112263459697	0.0334932789576539	HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DQB1/CXCR4/HLA-DPA1/FCGR1B/CTSH	8
GO:0042056	chemoattractant activity	4/313	37/18367	0.00350835860443092	0.0348188042628427	CCL3/HMGB2/HMGB1/CXCL10	4
GO:0003727	single-stranded RNA binding	6/313	87/18367	0.00371241125739019	0.0361616355812452	IFIH1/SSB/HNRNPA1/HMGB1/HNRNPU/ANXA1	6
GO:0043021	ribonucleoprotein complex binding	8/313	149/18367	0.00407369276384741	0.0382719120277309	EIF1B/SBDS/IFIH1/RPLP1/NPM1/HNRNPU/NEAT1/DDX5	8
GO:1990841	promoter-specific chromatin binding	5/313	62/18367	0.00407457618546185	0.0382719120277309	KLF4/EGR1/STAT1/HNRNPU/DDX5	5
GO:0019888	protein phosphatase regulator activity	6/313	89/18367	0.00415337150058709	0.0383276036720844	PPP1R15A/ENSA/EIF2AK2/PHACTR1/SET/CALM1	6
GO:0140677	molecular function activator activity	8/313	150/18367	0.00424124339415951	0.0384636900918604	CCL3/NUPR1/NCF1/DNAJB6/APOE/DNAJA1/CALM1/APOC1	8
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/313	20/18367	0.00450686466905755	0.0395101802654045	FOS/CEBPB/STAT1	3
GO:0016505	peptidase activator activity involved in apoptotic process	3/313	20/18367	0.00450686466905755	0.0395101802654045	CASP1/CTSH/RPS27L	3
GO:0044183	protein folding chaperone	4/313	40/18367	0.00466486222832327	0.0402248775753777	HSPA1A/HSP90AB1/HSPA1B/DNAJB6	4
GO:0001046	core promoter sequence-specific DNA binding	4/313	42/18367	0.00556358568828134	0.0472007430973546	FOS/CEBPB/STAT1/NPM1	4
GO:0055106	ubiquitin-protein transferase regulator activity	3/313	22/18367	0.00593725411585525	0.0495713597609502	TRIB1/RPL37/RPS15	3
GO:0019843	rRNA binding	5/313	68/18367	0.00604423528106444	0.0496760587162484	SBDS/CIRBP/NPM1/RPL12/RPL37	5
GO:0070412	R-SMAD binding	3/313	23/18367	0.00674276874696835	0.0544154439536217	JUN/FOS/DDX5	3
GO:0004860	protein kinase inhibitor activity	5/313	70/18367	0.00682779334779284	0.0544154439536217	SNCA/TRIB1/SOCS3/NPM1/PKIB	5
GO:0048156	tau protein binding	4/313	45/18367	0.00711718876086094	0.0558752431076546	SNCA/HSP90AB1/APOE/HSP90AA1	4
GO:0070003	threonine-type peptidase activity	3/313	24/18367	0.00761009001906551	0.0588662845592421	PSMB10/PSMB8/PSMB9	3
GO:0035035	histone acetyltransferase binding	3/313	25/18367	0.0085402682589526	0.0646457593343553	CEBPB/EGR1/STAT1	3
GO:0019210	kinase inhibitor activity	5/313	74/18367	0.00860304782016136	0.0646457593343553	SNCA/TRIB1/SOCS3/NPM1/PKIB	5
GO:0019003	GDP binding	5/313	75/18367	0.00909229005328186	0.0673597826482572	RHOB/RALA/GBP1/RAB8A/RAB2A	5
GO:0019212	phosphatase inhibitor activity	4/313	49/18367	0.00959929845227717	0.0682406333375314	ANP32E/ENSA/PHACTR1/SET	4
GO:0032813	tumor necrosis factor receptor superfamily binding	4/313	49/18367	0.00959929845227717	0.0682406333375314	BID/TNFSF13B/STAT1/TNFSF10	4
GO:0001618	virus receptor activity	5/313	76/18367	0.00960039328322686	0.0682406333375314	PLSCR1/HSPA1A/CXCR4/EGFR/HSPA1B	5
GO:0051087	chaperone binding	6/313	107/18367	0.0100329027578251	0.0691839824784149	HLA-B/PTGES3/DNAJB6/DNAJA1/FN1/HES1	6
GO:0003724	RNA helicase activity	5/313	77/18367	0.0101276932525436	0.0691839824784149	IFIH1/EIF4A2/DDX24/DDX46/DDX5	5
GO:0140272	exogenous protein binding	5/313	77/18367	0.0101276932525436	0.0691839824784149	PLSCR1/HSPA1A/CXCR4/EGFR/HSPA1B	5
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	15/313	450/18367	0.0106542667268599	0.0718480038247219	JUND/JUN/FOSB/FOS/KLF4/KLF6/PLSCR1/JUNB/CEBPB/ATF3/EGR1/MAFB/NR4A2/ZNF292/CEBPD	15
GO:0004601	peroxidase activity	4/313	51/18367	0.0110269628464894	0.0728565382548118	PRDX3/HBA2/HBA1/PRDX1	4
GO:0008186	ATP-dependent activity, acting on RNA	5/313	79/18367	0.0112411985934855	0.0728565382548118	IFIH1/EIF4A2/DDX24/DDX46/DDX5	5
GO:0008047	enzyme activator activity	6/313	110/18367	0.0114019566221777	0.0728565382548118	CCL3/NUPR1/NCF1/APOE/CALM1/APOC1	6
GO:0008330	protein tyrosine/threonine phosphatase activity	2/313	10/18367	0.0119015902599295	0.0728565382548118	DUSP1/DUSP2	2
GO:0030957	Tat protein binding	2/313	10/18367	0.0119015902599295	0.0728565382548118	NPM1/DNAJA1	2
GO:0031720	haptoglobin binding	2/313	10/18367	0.0119015902599295	0.0728565382548118	HBA2/HBA1	2
GO:0070008	serine-type exopeptidase activity	2/313	10/18367	0.0119015902599295	0.0728565382548118	SCPEP1/CPVL	2
GO:0001216	DNA-binding transcription activator activity	15/313	456/18367	0.0119119054941327	0.0728565382548118	JUND/JUN/FOSB/FOS/KLF4/KLF6/PLSCR1/JUNB/CEBPB/ATF3/EGR1/MAFB/NR4A2/ZNF292/CEBPD	15
GO:0070566	adenylyltransferase activity	3/313	30/18367	0.0141632950686738	0.0804452066252312	OAS1/OAS2/OAS3	3
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	4/313	55/18367	0.0142764850186506	0.0804452066252312	PRDX3/HBA2/HBA1/PRDX1	4
GO:0008135	translation factor activity, RNA binding	5/313	84/18367	0.0143832951794565	0.0804452066252312	EIF1B/ABCF1/EEF1A1/EIF4A2/EIF3E	5
GO:0008603	cAMP-dependent protein kinase regulator activity	2/313	11/18367	0.014384003077409	0.0804452066252312	PKIB/CXCL10	2
GO:0019864	IgG binding	2/313	11/18367	0.014384003077409	0.0804452066252312	FCGR1B/FCGR2A	2
GO:0051400	BH domain binding	2/313	11/18367	0.014384003077409	0.0804452066252312	BCL2A1/MCL1	2
GO:0097371	MDM2/MDM4 family protein binding	2/313	11/18367	0.014384003077409	0.0804452066252312	RPL37/RPS15	2
GO:0097493	structural molecule activity conferring elasticity	2/313	11/18367	0.014384003077409	0.0804452066252312	FBN2/FBN1	2
GO:0019903	protein phosphatase binding	7/313	150/18367	0.0145290772421995	0.0804452066252312	PPP1R15A/ENSA/GRB2/PHACTR1/EGFR/STAT1/SNX3	7
GO:0005164	tumor necrosis factor receptor binding	3/313	31/18367	0.0154867937136123	0.0848547238891675	TNFSF13B/STAT1/TNFSF10	3
GO:0071889	14-3-3 protein binding	3/313	32/18367	0.0168776490571301	0.0915220969489733	ZFP36/DDIT4/HLA-F	3
GO:0035325	Toll-like receptor binding	2/313	12/18367	0.0170683925533603	0.0916119845210972	S100A8/S100A9	2
GO:0004386	helicase activity	7/313	156/18367	0.0176582376272552	0.0938205352720834	IFIH1/EIF4A2/DDX24/CHD2/DDX46/DDX5/ANXA1	7
GO:0005154	epidermal growth factor receptor binding	3/313	33/18367	0.01833614439781	0.0954931876559214	PLSCR1/GRB2/SNX2	3
GO:0019956	chemokine binding	3/313	33/18367	0.01833614439781	0.0954931876559214	ZFP36/CXCR4/HMGB1	3
GO:0003697	single-stranded DNA binding	6/313	123/18367	0.018871485402819	0.0973176600184589	HMGB2/SUB1/HNRNPA1/HMGB1/HNRNPU/ANXA1	6
GO:0004859	phospholipase inhibitor activity	2/313	13/18367	0.0199471993409524	0.0989832722013296	ANXA1/APOC1	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/313	13/18367	0.0199471993409524	0.0989832722013296	PRDX3/GLRX	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/313	13/18367	0.0199471993409524	0.0989832722013296	DUSP1/DUSP2	2
GO:0072542	protein phosphatase activator activity	2/313	13/18367	0.0199471993409524	0.0989832722013296	PPP1R15A/CALM1	2
GO:0048018	receptor ligand activity	15/313	487/18367	0.0203628457790234	0.10010146616604	CCL3/CCL3L3/CCL4/HMGB2/CXCL8/IL1B/TYMP/TNFSF13B/METRNL/CXCL2/TNFSF10/HMGB1/CXCL3/FBN1/CXCL10	15
GO:0003712	transcription coregulator activity	15/313	489/18367	0.021033488740174	0.102440880345662	HSPA1A/LMO2/HMGB2/SAP30/SUB1/NUPR1/NMI/TRIM22/CAMTA1/BASP1/SAP18/BTG1/NPM1/HMGB1/HNRNPU	15
GO:0005344	oxygen carrier activity	2/313	14/18367	0.0230130616474923	0.107741950310753	HBA2/HBA1	2
GO:0036041	long-chain fatty acid binding	2/313	14/18367	0.0230130616474923	0.107741950310753	S100A8/S100A9	2
GO:0044548	S100 protein binding	2/313	14/18367	0.0230130616474923	0.107741950310753	CACYBP/S100A6	2
GO:0043394	proteoglycan binding	3/313	36/18367	0.0231191420221028	0.107741950310753	SDCBP/APOE/FN1	3
GO:0030546	signaling receptor activator activity	15/313	495/18367	0.023146084382348	0.107741950310753	CCL3/CCL3L3/CCL4/HMGB2/CXCL8/IL1B/TYMP/TNFSF13B/METRNL/CXCL2/TNFSF10/HMGB1/CXCL3/FBN1/CXCL10	15
GO:0044325	transmembrane transporter binding	6/313	133/18367	0.0265038691808116	0.122289782360587	YWHAH/VAMP2/SRI/HSP90AB1/HERPUD1/CALM1	6
GO:0015631	tubulin binding	12/313	375/18367	0.0278048917015414	0.127104404796528	SNCA/MX1/MX2/GABARAPL2/BEX4/SBDS/CACYBP/MAP1LC3B/S100A8/HSPH1/ALDOA/S100A9	12
GO:0005504	fatty acid binding	3/313	39/18367	0.0285139159049245	0.127104404796528	S100A8/S100A9/APOC1	3
GO:0019825	oxygen binding	3/313	39/18367	0.0285139159049245	0.127104404796528	SOD2/HBA2/HBA1	3
GO:0050997	quaternary ammonium group binding	3/313	39/18367	0.0285139159049245	0.127104404796528	VDAC2/TKT/APOC1	3
GO:0005521	lamin binding	2/313	16/18367	0.0296774664971059	0.130086228145648	BNIP3L/IFI27	2
GO:0008191	metalloendopeptidase inhibitor activity	2/313	16/18367	0.0296774664971059	0.130086228145648	BST2/TIMP3	2
GO:0017080	sodium channel regulator activity	3/313	40/18367	0.030447622959784	0.131274177679069	YWHAH/SGK1/FXYD3	3
GO:0043014	alpha-tubulin binding	3/313	40/18367	0.030447622959784	0.131274177679069	SNCA/BEX4/HSPH1	3
GO:0099106	ion channel regulator activity	6/313	139/18367	0.0319456974886406	0.136613307959552	YWHAH/ENSA/SRI/SGK1/FXYD3/CALM1	6
GO:0000400	four-way junction DNA binding	2/313	17/18367	0.0332622331768064	0.139967477208001	HMGB2/HMGB1	2
GO:0043024	ribosomal small subunit binding	2/313	17/18367	0.0332622331768064	0.139967477208001	EIF1B/NPM1	2
GO:0004180	carboxypeptidase activity	3/313	43/18367	0.0366515110819285	0.147465275978291	SCPEP1/LAP3/CPVL	3
GO:0005246	calcium channel regulator activity	3/313	43/18367	0.0366515110819285	0.147465275978291	SRI/SGK1/CALM1	3
GO:0016922	nuclear receptor binding	6/313	144/18367	0.0369995849750886	0.147465275978291	JUND/YWHAH/CEBPB/STAT1/NR4A2/DDX5	6
GO:0008301	DNA binding, bending	2/313	18/18367	0.0370064951124228	0.147465275978291	HMGB2/HMGB1	2
GO:0033549	MAP kinase phosphatase activity	2/313	18/18367	0.0370064951124228	0.147465275978291	DUSP1/DUSP2	2
GO:0048038	quinone binding	2/313	18/18367	0.0370064951124228	0.147465275978291	AOC1/SDHD	2
GO:0055102	lipase inhibitor activity	2/313	18/18367	0.0370064951124228	0.147465275978291	ANXA1/APOC1	2
GO:0017022	myosin binding	4/313	74/18367	0.0375665046825346	0.148571289195588	VAMP2/RALA/CXCR4/RAB8A	4
GO:0016247	channel regulator activity	6/313	145/18367	0.0380682682653614	0.149432157519254	YWHAH/ENSA/SRI/SGK1/FXYD3/CALM1	6
GO:0003779	actin binding	13/313	440/18367	0.0392499853950001	0.152929572724223	YWHAH/SNCA/TMSB4X/GBP1/CXCR4/PHACTR1/EGFR/MARCKS/HNRNPU/ALDOA/ARPC3/IQGAP2/TPM3	13
GO:0004864	protein phosphatase inhibitor activity	3/313	46/18367	0.0434514366147948	0.167195229166151	ENSA/PHACTR1/SET	3
GO:0008022	protein C-terminus binding	7/313	189/18367	0.043547046379777	0.167195229166151	FBLN1/NCL/TNFAIP3/VAMP2/PRDX3/SDCBP/FN1	7
GO:0016887	ATP hydrolysis activity	9/313	272/18367	0.044115328209856	0.16767804851762	HSPA1A/IFIH1/EIF4A2/DDX24/CHD2/DDX46/HSPA1B/DDX5/HSP90AA1	9
GO:0019211	phosphatase activator activity	2/313	20/18367	0.0449479179486397	0.16767804851762	PPP1R15A/CALM1	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/313	20/18367	0.0449479179486397	0.16767804851762	KLF4/SOCS3	2
GO:0097001	ceramide binding	2/313	20/18367	0.0449479179486397	0.16767804851762	VDAC2/MAP1LC3B	2
GO:0061135	endopeptidase regulator activity	7/313	194/18367	0.0488913243593743	0.181104483190358	SNCA/PRDX3/BST2/SERPINF1/PSME2/TIMP3/ITIH5	7
GO:0019902	phosphatase binding	7/313	196/18367	0.0511406941758871	0.188111924031585	PPP1R15A/ENSA/GRB2/PHACTR1/EGFR/STAT1/SNX3	7
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/313	22/18367	0.0534522570347297	0.195249216668527	SNCA/PRDX3	2
GO:0046982	protein heterodimerization activity	10/313	328/18367	0.0552900266546724	0.200569338071432	YWHAH/CEBPB/ATF3/SRI/BHLHE41/SNX2/SDCBP/BCL2A1/MCL1/NR4A2	10
GO:0003743	translation initiation factor activity	3/313	51/18367	0.0560709821238197	0.202009154774857	EIF1B/EIF4A2/EIF3E	3
GO:0005543	phospholipid binding	13/313	466/18367	0.0569874891010568	0.203914416783373	SNCA/PHLDA2/NCF1/VAMP2/VDAC2/SNX2/SDCBP/SNX3/APOE/HMGB1/IQGAP2/ANXA1/APOC1	13
GO:0019865	immunoglobulin binding	2/313	23/18367	0.0579007797288022	0.204189296833982	FCGR1B/FCGR2A	2
GO:0050750	low-density lipoprotein particle receptor binding	2/313	23/18367	0.0579007797288022	0.204189296833982	APOE/DNAJA1	2
GO:0042393	histone binding	8/313	244/18367	0.0582288869298429	0.204189296833982	SNCA/ANP32E/ANP32B/STAT1/CHD2/SET/NPM1/NAP1L1	8
GO:0008171	O-methyltransferase activity	2/313	24/18367	0.0624726606115055	0.214775290729751	COMT/PCMT1	2
GO:0019957	C-C chemokine binding	2/313	24/18367	0.0624726606115055	0.214775290729751	ZFP36/CXCR4	2
GO:0043274	phospholipase binding	2/313	24/18367	0.0624726606115055	0.214775290729751	SNCA/SRSF3	2
GO:0051117	ATPase binding	4/313	89/18367	0.0656630045382856	0.224277534981417	GABARAPL2/RALA/EGFR/RAC1	4
GO:0030247	polysaccharide binding	2/313	25/18367	0.0671624338595537	0.227918969097582	HLA-DRB1/HLA-DRA	2
GO:0030371	translation repressor activity	2/313	26/18367	0.0719647830578619	0.242650486464329	PAIP2/CIRBP	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/313	57/18367	0.0732325428459827	0.245352340999916	PRDX3/GLRX/TXNDC12	3
GO:0005201	extracellular matrix structural constituent	6/313	172/18367	0.07448751326544	0.247977417579883	FBLN1/FBN2/IGFBP7/FN1/TINAGL1/FBN1	6
GO:0001671	ATPase activator activity	2/313	27/18367	0.0768745377215834	0.252725042759706	DNAJB6/DNAJA1	2
GO:0043425	bHLH transcription factor binding	2/313	27/18367	0.0768745377215834	0.252725042759706	LMO2/BHLHE41	2
GO:0036002	pre-mRNA binding	3/313	59/18367	0.0794147305526714	0.257918493194939	HNRNPA1/HNRNPU/DDX5	3
GO:0002020	protease binding	5/313	135/18367	0.0813723697696751	0.257918493194939	UBC/TNFAIP3/SRI/TIMP3/FN1	5
GO:0043177	organic acid binding	5/313	135/18367	0.0813723697696751	0.257918493194939	P4HA1/HBA2/S100A8/HBA1/S100A9	5
GO:0008187	poly-pyrimidine tract binding	2/313	28/18367	0.0818866698926899	0.257918493194939	SSB/HNRNPU	2
GO:0043236	laminin binding	2/313	28/18367	0.0818866698926899	0.257918493194939	TINAGL1/LGALS1	2
GO:0046875	ephrin receptor binding	2/313	28/18367	0.0818866698926899	0.257918493194939	GRB2/SDCBP	2
GO:0070325	lipoprotein particle receptor binding	2/313	28/18367	0.0818866698926899	0.257918493194939	APOE/DNAJA1	2
GO:0000287	magnesium ion binding	7/313	221/18367	0.0847536642337843	0.265359686827206	SNCA/PLSCR1/COMT/TKT/NT5C3A/PPA1/S100P	7
GO:0043621	protein self-association	3/313	61/18367	0.0858159893933843	0.266046796313011	TNFAIP3/VAMP2/RSAD2	3
GO:0046625	sphingolipid binding	2/313	29/18367	0.0869962908095777	0.266046796313011	VDAC2/MAP1LC3B	2
GO:0051059	NF-kappaB binding	2/313	29/18367	0.0869962908095777	0.266046796313011	NFKBIA/NPM1	2
GO:0051787	misfolded protein binding	2/313	29/18367	0.0869962908095777	0.266046796313011	HSPA1A/HSPA1B	2
GO:0004866	endopeptidase inhibitor activity	6/313	180/18367	0.0881131359081439	0.267904679119559	SNCA/PRDX3/BST2/SERPINF1/TIMP3/ITIH5	6
GO:0008017	microtubule binding	8/313	271/18367	0.0932881983120821	0.281685941082133	SNCA/MX1/MX2/GABARAPL2/SBDS/MAP1LC3B/S100A8/S100A9	8
GO:0070851	growth factor receptor binding	5/313	141/18367	0.0937168054931052	0.281685941082133	PLSCR1/IL1B/GRB2/SNX2/SDCBP	5
GO:0008157	protein phosphatase 1 binding	2/313	31/18367	0.0974891203333587	0.289713431047156	PPP1R15A/PHACTR1	2
GO:0031210	phosphatidylcholine binding	2/313	31/18367	0.0974891203333587	0.289713431047156	VDAC2/APOC1	2
GO:0005200	structural constituent of cytoskeleton	4/313	103/18367	0.099403021679746	0.292100499461153	HLA-DRB1/DSP/ARPC3/TUBA1B	4
GO:0008238	exopeptidase activity	4/313	103/18367	0.099403021679746	0.292100499461153	SCPEP1/LAP3/CTSH/CPVL	4
GO:0003714	transcription corepressor activity	6/313	187/18367	0.101079277442548	0.293744198534698	HSPA1A/SAP30/TRIM22/BASP1/SAP18/HNRNPU	6
GO:0030414	peptidase inhibitor activity	6/313	187/18367	0.101079277442548	0.293744198534698	SNCA/PRDX3/BST2/SERPINF1/TIMP3/ITIH5	6
GO:0051721	protein phosphatase 2A binding	2/313	32/18367	0.10286321841844	0.297286004879669	ENSA/STAT1	2
GO:0097110	scaffold protein binding	3/313	67/18367	0.10625822469138	0.305419815233146	DSP/KRT8/HSP90AA1	3
GO:0008200	ion channel inhibitor activity	2/313	33/18367	0.108316578032675	0.309644130680364	ENSA/CALM1	2
GO:0016248	channel inhibitor activity	2/313	34/18367	0.113844958894057	0.32194864719502	ENSA/CALM1	2
GO:0035198	miRNA binding	2/313	34/18367	0.113844958894057	0.32194864719502	HNRNPA1/NEAT1	2
GO:0000149	SNARE binding	4/313	110/18367	0.118762718945548	0.334059840456461	SNCA/GABARAPL2/TNFAIP2/VAMP2	4
GO:0048029	monosaccharide binding	3/313	71/18367	0.120839187885167	0.338092621423394	HK2/P4HA1/ALDOA	3
GO:0000217	DNA secondary structure binding	2/313	36/18367	0.125110423702454	0.344544936479009	HMGB2/HMGB1	2
GO:0042162	telomeric DNA binding	2/313	36/18367	0.125110423702454	0.344544936479009	NCL/HNRNPA1	2
GO:0061631	ubiquitin conjugating enzyme activity	2/313	36/18367	0.125110423702454	0.344544936479009	UBE2B/UBE2L6	2
GO:0033293	monocarboxylic acid binding	3/313	73/18367	0.12839105711722	0.346326646377731	S100A8/S100A9/APOC1	3
GO:0070063	RNA polymerase binding	3/313	73/18367	0.12839105711722	0.346326646377731	ZFP36/ANP32B/HNRNPU	3
GO:0106306	protein serine phosphatase activity	3/313	73/18367	0.12839105711722	0.346326646377731	DUSP1/DUSP2/PPP4C	3
GO:0106307	protein threonine phosphatase activity	3/313	73/18367	0.12839105711722	0.346326646377731	DUSP1/DUSP2/PPP4C	3
GO:0005516	calmodulin binding	6/313	201/18367	0.129818224038299	0.348389723694618	VAMP2/RGS1/EGFR/MARCKS/DDX5/IQGAP2	6
GO:0015035	protein-disulfide reductase activity	2/313	37/18367	0.130839619041746	0.349348424446489	GLRX/TXNDC12	2
GO:0061650	ubiquitin-like protein conjugating enzyme activity	2/313	39/18367	0.142472060282629	0.378486382366983	UBE2B/UBE2L6	2
GO:0001221	transcription coregulator binding	3/313	78/18367	0.147966527765849	0.388266725450748	KLF4/LMO2/STAT1	3
GO:0003925	G protein activity	2/313	40/18367	0.148368083299621	0.388266725450748	RALA/RAC1	2
GO:0004177	aminopeptidase activity	2/313	40/18367	0.148368083299621	0.388266725450748	LAP3/CTSH	2
GO:0046332	SMAD binding	3/313	79/18367	0.151992567900701	0.389205628638938	JUN/FOS/DDX5	3
GO:0048487	beta-tubulin binding	2/313	41/18367	0.154312668389806	0.389205628638938	SNCA/GABARAPL2	2
GO:0008201	heparin binding	5/313	166/18367	0.154398754212571	0.389205628638938	AOC1/APOE/FN1/FBN1/CXCL10	5
GO:0004955	prostaglandin receptor activity	1/313	10/18367	0.157958167472983	0.389205628638938	PTGER4	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/313	10/18367	0.157958167472983	0.389205628638938	NCF1	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/313	10/18367	0.157958167472983	0.389205628638938	NCF1	1
GO:0047844	deoxycytidine deaminase activity	1/313	10/18367	0.157958167472983	0.389205628638938	APOBEC3A	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/313	10/18367	0.157958167472983	0.389205628638938	CASP1	1
GO:0098505	G-rich strand telomeric DNA binding	1/313	10/18367	0.157958167472983	0.389205628638938	HNRNPA1	1
GO:0015036	disulfide oxidoreductase activity	2/313	42/18367	0.160302463921273	0.389205628638938	GLRX/TXNDC12	2
GO:0003713	transcription coactivator activity	7/313	262/18367	0.161375738935011	0.389205628638938	LMO2/HMGB2/SUB1/NUPR1/TRIM22/NPM1/HMGB1	7
GO:0030544	Hsp70 protein binding	2/313	43/18367	0.166334217718314	0.389205628638938	SNCA/DNAJA1	2
GO:0009055	electron transfer activity	4/313	126/18367	0.168367016267801	0.389205628638938	NCF1/SDHD/ALDH2/UQCR11	4
GO:0000774	adenyl-nucleotide exchange factor activity	1/313	11/18367	0.172315583912541	0.389205628638938	HSPH1	1
GO:0004954	prostanoid receptor activity	1/313	11/18367	0.172315583912541	0.389205628638938	PTGER4	1
GO:0005536	glucose binding	1/313	11/18367	0.172315583912541	0.389205628638938	HK2	1
GO:0016273	arginine N-methyltransferase activity	1/313	11/18367	0.172315583912541	0.389205628638938	PRMT9	1
GO:0016274	protein-arginine N-methyltransferase activity	1/313	11/18367	0.172315583912541	0.389205628638938	PRMT9	1
GO:0016832	aldehyde-lyase activity	1/313	11/18367	0.172315583912541	0.389205628638938	ALDOA	1
GO:0017128	phospholipid scramblase activity	1/313	11/18367	0.172315583912541	0.389205628638938	PLSCR1	1
GO:0019855	calcium channel inhibitor activity	1/313	11/18367	0.172315583912541	0.389205628638938	CALM1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/313	11/18367	0.172315583912541	0.389205628638938	TRIB1	1
GO:0031996	thioesterase binding	1/313	11/18367	0.172315583912541	0.389205628638938	RAC1	1
GO:0043560	insulin receptor substrate binding	1/313	11/18367	0.172315583912541	0.389205628638938	GRB2	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/313	11/18367	0.172315583912541	0.389205628638938	GLRX	1
GO:0070513	death domain binding	1/313	11/18367	0.172315583912541	0.389205628638938	MCL1	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/313	11/18367	0.172315583912541	0.389205628638938	DSP	1
GO:0140036	ubiquitin-dependent protein binding	1/313	11/18367	0.172315583912541	0.389205628638938	LAPTM5	1
GO:1990226	histone methyltransferase binding	1/313	11/18367	0.172315583912541	0.389205628638938	HSP90AB1	1
GO:1990459	transferrin receptor binding	1/313	11/18367	0.172315583912541	0.389205628638938	SNX2	1
GO:0001784	phosphotyrosine residue binding	2/313	44/18367	0.172404774663256	0.389205628638938	GRB2/SOCS3	2
GO:0051879	Hsp90 protein binding	2/313	44/18367	0.172404774663256	0.389205628638938	PTGES3/GBP1	2
GO:0030246	carbohydrate binding	7/313	271/18367	0.181407851448335	0.400251573719069	HLA-DRB1/HLA-DRA/HK2/CD69/P4HA1/ALDOA/LGALS1	7
GO:0061980	regulatory RNA binding	2/313	46/18367	0.184650148793267	0.400251573719069	HNRNPA1/NEAT1	2
GO:0003964	RNA-directed DNA polymerase activity	1/313	12/18367	0.186428964945194	0.400251573719069	PTGES3	1
GO:0004126	cytidine deaminase activity	1/313	12/18367	0.186428964945194	0.400251573719069	APOBEC3A	1
GO:0005095	GTPase inhibitor activity	1/313	12/18367	0.186428964945194	0.400251573719069	IQGAP2	1
GO:0005165	neurotrophin receptor binding	1/313	12/18367	0.186428964945194	0.400251573719069	GRB2	1
GO:0031543	peptidyl-proline dioxygenase activity	1/313	12/18367	0.186428964945194	0.400251573719069	P4HA1	1
GO:0033130	acetylcholine receptor binding	1/313	12/18367	0.186428964945194	0.400251573719069	LY6E	1
GO:0035256	G protein-coupled glutamate receptor binding	1/313	12/18367	0.186428964945194	0.400251573719069	CALM1	1
GO:0043047	single-stranded telomeric DNA binding	1/313	12/18367	0.186428964945194	0.400251573719069	HNRNPA1	1
GO:0043422	protein kinase B binding	1/313	12/18367	0.186428964945194	0.400251573719069	SRSF5	1
GO:0061578	Lys63-specific deubiquitinase activity	1/313	12/18367	0.186428964945194	0.400251573719069	TNFAIP3	1
GO:0016779	nucleotidyltransferase activity	4/313	132/18367	0.18860122061334	0.403269276596003	OAS1/OAS2/PTGES3/OAS3	4
GO:0051219	phosphoprotein binding	3/313	88/18367	0.189658266519443	0.403887644490799	SNCA/GRB2/SOCS3	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/313	47/18367	0.190819120177251	0.40472119844046	DUSP1/DUSP2	2
GO:0070888	E-box binding	2/313	48/18367	0.197015198668026	0.411558930807908	BHLHE41/HES1	2
GO:0008179	adenylate cyclase binding	1/313	13/18367	0.200302445412214	0.411558930807908	CALM1	1
GO:0008253	5'-nucleotidase activity	1/313	13/18367	0.200302445412214	0.411558930807908	NT5C3A	1
GO:0008494	translation activator activity	1/313	13/18367	0.200302445412214	0.411558930807908	RPS27L	1
GO:0031432	titin binding	1/313	13/18367	0.200302445412214	0.411558930807908	CALM1	1
GO:0060590	ATPase regulator activity	1/313	13/18367	0.200302445412214	0.411558930807908	HSPH1	1
GO:0061133	endopeptidase activator activity	1/313	13/18367	0.200302445412214	0.411558930807908	PSME2	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/313	13/18367	0.200302445412214	0.411558930807908	LAPTM5	1
GO:0098632	cell-cell adhesion mediator activity	2/313	49/18367	0.203235680263312	0.415960964274327	DSP/ANXA1	2
GO:0043130	ubiquitin binding	3/313	92/18367	0.207102332817259	0.422231887836737	TNFAIP3/UBE2L6/CXCR4	3
GO:0019955	cytokine binding	4/313	139/18367	0.213122480781775	0.429513311094822	ZFP36/GBP1/CXCR4/HMGB1	4
GO:0043023	ribosomal large subunit binding	1/313	14/18367	0.213940090317193	0.429513311094822	NPM1	1
GO:0071837	HMG box domain binding	1/313	14/18367	0.213940090317193	0.429513311094822	JUN	1
GO:0140666	annealing activity	1/313	14/18367	0.213940090317193	0.429513311094822	ANXA1	1
GO:0019838	growth factor binding	4/313	141/18367	0.220287445869376	0.431051465080154	DUSP1/EGFR/IGFBP7/SDCBP	4
GO:0008236	serine-type peptidase activity	5/313	191/18367	0.227341142256323	0.431051465080154	SCPEP1/CFD/SEC11A/CTSH/CPVL	5
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/313	15/18367	0.227345896001861	0.431051465080154	ALDH2	1
GO:0004953	icosanoid receptor activity	1/313	15/18367	0.227345896001861	0.431051465080154	PTGER4	1
GO:0008252	nucleotidase activity	1/313	15/18367	0.227345896001861	0.431051465080154	NT5C3A	1
GO:0010851	cyclase regulator activity	1/313	15/18367	0.227345896001861	0.431051465080154	CALM1	1
GO:0030548	acetylcholine receptor regulator activity	1/313	15/18367	0.227345896001861	0.431051465080154	LY6E	1
GO:0042043	neurexin family protein binding	1/313	15/18367	0.227345896001861	0.431051465080154	SDCBP	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/313	15/18367	0.227345896001861	0.431051465080154	NCF1	1
GO:0050998	nitric-oxide synthase binding	1/313	15/18367	0.227345896001861	0.431051465080154	CALM1	1
GO:0071933	Arp2/3 complex binding	1/313	15/18367	0.227345896001861	0.431051465080154	IQGAP2	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/313	15/18367	0.227345896001861	0.431051465080154	CASP1	1
GO:0098847	sequence-specific single stranded DNA binding	1/313	15/18367	0.227345896001861	0.431051465080154	HNRNPA1	1
GO:0099602	neurotransmitter receptor regulator activity	1/313	15/18367	0.227345896001861	0.431051465080154	LY6E	1
GO:0017069	snRNA binding	2/313	53/18367	0.2283104454994	0.431051465080154	LARP7/HNRNPU	2
GO:0004722	protein serine/threonine phosphatase activity	3/313	98/18367	0.233893538470985	0.431051465080154	DUSP1/DUSP2/PPP4C	3
GO:0015459	potassium channel regulator activity	2/313	54/18367	0.234615242323333	0.431051465080154	ENSA/SGK1	2
GO:0017171	serine hydrolase activity	5/313	195/18367	0.239865271384419	0.431051465080154	SCPEP1/CFD/SEC11A/CTSH/CPVL	5
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/313	16/18367	0.240523791302178	0.431051465080154	PAIP2	1
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/313	16/18367	0.240523791302178	0.431051465080154	ALDH2	1
GO:0004698	calcium-dependent protein kinase C activity	1/313	16/18367	0.240523791302178	0.431051465080154	CCL3	1
GO:0005159	insulin-like growth factor receptor binding	1/313	16/18367	0.240523791302178	0.431051465080154	YWHAH	1
GO:0005523	tropomyosin binding	1/313	16/18367	0.240523791302178	0.431051465080154	S100A6	1
GO:0016004	phospholipase activator activity	1/313	16/18367	0.240523791302178	0.431051465080154	CCL3	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/313	16/18367	0.240523791302178	0.431051465080154	AOC1	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/313	16/18367	0.240523791302178	0.431051465080154	DNASE2	1
GO:0017070	U6 snRNA binding	1/313	16/18367	0.240523791302178	0.431051465080154	LARP7	1
GO:0035497	cAMP response element binding	1/313	16/18367	0.240523791302178	0.431051465080154	JUN	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/313	16/18367	0.240523791302178	0.431051465080154	SOCS3	1
GO:0050700	CARD domain binding	1/313	16/18367	0.240523791302178	0.431051465080154	CASP1	1
GO:0070492	oligosaccharide binding	1/313	16/18367	0.240523791302178	0.431051465080154	LGALS1	1
GO:0005080	protein kinase C binding	2/313	55/18367	0.240929906337577	0.431051465080154	DSP/MARCKS	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/313	56/18367	0.247252278108184	0.434297192014063	SNCA/PRDX3	2
GO:0045309	protein phosphorylated amino acid binding	2/313	56/18367	0.247252278108184	0.434297192014063	GRB2/SOCS3	2
GO:0050840	extracellular matrix binding	2/313	56/18367	0.247252278108184	0.434297192014063	TINAGL1/LGALS1	2
GO:0051287	NAD binding	2/313	56/18367	0.247252278108184	0.434297192014063	ALDH2/LDHA	2
GO:0030295	protein kinase activator activity	3/313	101/18367	0.24751548451533	0.434297192014063	RPLP1/HMGB1/CALM1	3
GO:0004697	protein kinase C activity	1/313	17/18367	0.253477638685014	0.434297192014063	CCL3	1
GO:0005149	interleukin-1 receptor binding	1/313	17/18367	0.253477638685014	0.434297192014063	IL1B	1
GO:0008308	voltage-gated anion channel activity	1/313	17/18367	0.253477638685014	0.434297192014063	VDAC2	1
GO:0017081	chloride channel regulator activity	1/313	17/18367	0.253477638685014	0.434297192014063	SGK1	1
GO:0031489	myosin V binding	1/313	17/18367	0.253477638685014	0.434297192014063	RAB8A	1
GO:0032393	MHC class I receptor activity	1/313	17/18367	0.253477638685014	0.434297192014063	CTSH	1
GO:0043395	heparan sulfate proteoglycan binding	1/313	17/18367	0.253477638685014	0.434297192014063	APOE	1
GO:0046965	retinoid X receptor binding	1/313	17/18367	0.253477638685014	0.434297192014063	NR4A2	1
GO:0005506	iron ion binding	4/313	151/18367	0.256986179063182	0.438878994114394	SNCA/P4HA1/HBA2/HBA1	4
GO:0050811	GABA receptor binding	1/313	18/18367	0.266211235365754	0.448861913420379	GABARAPL2	1
GO:0060229	lipase activator activity	1/313	18/18367	0.266211235365754	0.448861913420379	CCL3	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/313	18/18367	0.266211235365754	0.448861913420379	ANXA1	1
GO:0098631	cell adhesion mediator activity	2/313	59/18367	0.266245089329198	0.448861913420379	DSP/ANXA1	2
GO:0032934	sterol binding	2/313	60/18367	0.272578077295456	0.458070506892683	VDAC2/GPR183	2
GO:0019209	kinase activator activity	3/313	107/18367	0.275091416292765	0.460821926656034	RPLP1/HMGB1/CALM1	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7/313	310/18367	0.278307774768769	0.461340036630431	JUN/CEBPB/IRF8/ATF3/CREM/BHLHE41/HES1	7
GO:0003746	translation elongation factor activity	1/313	19/18367	0.278728314407147	0.461340036630431	EEF1A1	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/313	19/18367	0.278728314407147	0.461340036630431	SNX3	1
GO:0005507	copper ion binding	2/313	61/18367	0.278908995529424	0.461340036630431	SNCA/AOC1	2
GO:0001217	DNA-binding transcription repressor activity	7/313	313/18367	0.286285968177476	0.472057740631199	JUN/CEBPB/IRF8/ATF3/CREM/BHLHE41/HES1	7
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/313	20/18367	0.2910325457997	0.473941545172267	HNRNPU	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/313	20/18367	0.2910325457997	0.473941545172267	AOC1	1
GO:0031418	L-ascorbic acid binding	1/313	20/18367	0.2910325457997	0.473941545172267	P4HA1	1
GO:0042288	MHC class I protein binding	1/313	20/18367	0.2910325457997	0.473941545172267	PILRA	1
GO:0032182	ubiquitin-like protein binding	3/313	111/18367	0.293648201545121	0.476725166705969	TNFAIP3/UBE2L6/CXCR4	3
GO:1901681	sulfur compound binding	6/313	265/18367	0.298449164603957	0.483028494097481	AOC1/TKT/APOE/FN1/FBN1/CXCL10	6
GO:0005123	death receptor binding	1/313	21/18367	0.303127537523944	0.487599647515579	BID	1
GO:0019200	carbohydrate kinase activity	1/313	21/18367	0.303127537523944	0.487599647515579	HK2	1
GO:0030145	manganese ion binding	2/313	65/18367	0.304177600572712	0.487797005796484	LAP3/SOD2	2
GO:0051015	actin filament binding	5/313	217/18367	0.311512172624527	0.496104359427832	EGFR/MARCKS/ARPC3/IQGAP2/TPM3	5
GO:0008093	cytoskeletal anchor activity	1/313	22/18367	0.315016836594859	0.496104359427832	SDCBP	1
GO:0008320	protein transmembrane transporter activity	1/313	22/18367	0.315016836594859	0.496104359427832	MCL1	1
GO:0017075	syntaxin-1 binding	1/313	22/18367	0.315016836594859	0.496104359427832	VAMP2	1
GO:0070034	telomerase RNA binding	1/313	22/18367	0.315016836594859	0.496104359427832	HNRNPU	1
GO:0120020	cholesterol transfer activity	1/313	22/18367	0.315016836594859	0.496104359427832	APOE	1
GO:0035091	phosphatidylinositol binding	6/313	271/18367	0.316292497813741	0.496626429403068	PHLDA2/NCF1/SNX2/SDCBP/SNX3/IQGAP2	6
GO:0003684	damaged DNA binding	2/313	68/18367	0.323026762663987	0.501009525442254	HMGB2/HMGB1	2
GO:0005158	insulin receptor binding	1/313	23/18367	0.32670393008877	0.501009525442254	SNX2	1
GO:0008143	poly(A) binding	1/313	23/18367	0.32670393008877	0.501009525442254	HNRNPU	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/313	23/18367	0.32670393008877	0.501009525442254	CCL3	1
GO:0016493	C-C chemokine receptor activity	1/313	23/18367	0.32670393008877	0.501009525442254	CXCR4	1
GO:0016849	phosphorus-oxygen lyase activity	1/313	23/18367	0.32670393008877	0.501009525442254	RNASET2	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/313	23/18367	0.32670393008877	0.501009525442254	TNFAIP3	1
GO:0120015	sterol transfer activity	1/313	23/18367	0.32670393008877	0.501009525442254	APOE	1
GO:0001965	G-protein alpha-subunit binding	1/313	24/18367	0.338192246152999	0.512648765061895	RGS1	1
GO:0010857	calcium-dependent protein kinase activity	1/313	24/18367	0.338192246152999	0.512648765061895	CCL3	1
GO:0019789	SUMO transferase activity	1/313	24/18367	0.338192246152999	0.512648765061895	SUMO2	1
GO:0070840	dynein complex binding	1/313	24/18367	0.338192246152999	0.512648765061895	SNCA	1
GO:1901981	phosphatidylinositol phosphate binding	4/313	173/18367	0.340976075987237	0.515383379222088	PHLDA2/SDCBP/SNX3/IQGAP2	4
GO:0000049	tRNA binding	2/313	72/18367	0.347949401244445	0.520762582235814	SSB/EEF1A1	2
GO:0003678	DNA helicase activity	2/313	72/18367	0.347949401244445	0.520762582235814	CHD2/ANXA1	2
GO:0008266	poly(U) RNA binding	1/313	25/18367	0.349485154998559	0.520762582235814	SSB	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	1/313	25/18367	0.349485154998559	0.520762582235814	ZFP36	1
GO:0051019	mitogen-activated protein kinase binding	1/313	25/18367	0.349485154998559	0.520762582235814	DUSP1	1
GO:0031406	carboxylic acid binding	4/313	176/18367	0.352581608180234	0.523892446053116	P4HA1/S100A8/S100A9/APOC1	4
GO:0140104	molecular carrier activity	2/313	73/18367	0.354134143332536	0.524717068712433	HBA2/HBA1	2
GO:0005539	glycosaminoglycan binding	5/313	230/18367	0.355181715722815	0.524790961994946	AOC1/APOE/FN1/FBN1/CXCL10	5
GO:0001637	G protein-coupled chemoattractant receptor activity	1/313	26/18367	0.360585969876187	0.526856167096873	CXCR4	1
GO:0004950	chemokine receptor activity	1/313	26/18367	0.360585969876187	0.526856167096873	CXCR4	1
GO:0008198	ferrous iron binding	1/313	26/18367	0.360585969876187	0.526856167096873	SNCA	1
GO:0042974	retinoic acid receptor binding	1/313	26/18367	0.360585969876187	0.526856167096873	NR4A2	1
GO:0004709	MAP kinase kinase kinase activity	1/313	27/18367	0.371497948035979	0.533901422587227	EGFR	1
GO:0008139	nuclear localization sequence binding	1/313	27/18367	0.371497948035979	0.533901422587227	NFKBIA	1
GO:0022884	macromolecule transmembrane transporter activity	1/313	27/18367	0.371497948035979	0.533901422587227	MCL1	1
GO:0030507	spectrin binding	1/313	27/18367	0.371497948035979	0.533901422587227	GBP1	1
GO:0048027	mRNA 5'-UTR binding	1/313	27/18367	0.371497948035979	0.533901422587227	NCL	1
GO:0070006	metalloaminopeptidase activity	1/313	27/18367	0.371497948035979	0.533901422587227	LAP3	1
GO:0017124	SH3 domain binding	3/313	130/18367	0.38209043791341	0.540456928545436	PLSCR1/NCF1/GRB2	3
GO:0001968	fibronectin binding	1/313	28/18367	0.382224291670916	0.540456928545436	FBLN1	1
GO:0003785	actin monomer binding	1/313	28/18367	0.382224291670916	0.540456928545436	TMSB4X	1
GO:0050681	androgen receptor binding	1/313	28/18367	0.382224291670916	0.540456928545436	DDX5	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/313	28/18367	0.382224291670916	0.540456928545436	SNX3	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/313	28/18367	0.382224291670916	0.540456928545436	HERPUD1	1
GO:0030674	protein-macromolecule adaptor activity	6/313	296/18367	0.391904065715957	0.546550387016471	KLF4/VAMP2/TRIM22/GRB2/HERPUD1/SDCBP	6
GO:0005520	insulin-like growth factor binding	1/313	29/18367	0.392768148844536	0.546550387016471	IGFBP7	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/313	29/18367	0.392768148844536	0.546550387016471	BLVRA	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/313	29/18367	0.392768148844536	0.546550387016471	NCF1	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/313	29/18367	0.392768148844536	0.546550387016471	SNX3	1
GO:0070717	poly-purine tract binding	1/313	29/18367	0.392768148844536	0.546550387016471	HNRNPU	1
GO:0022829	wide pore channel activity	1/313	30/18367	0.40313261440303	0.5594927577203	VDAC2	1
GO:0008234	cysteine-type peptidase activity	4/313	190/18367	0.406607526636326	0.56283041844923	CASP1/TNFAIP3/OTUD1/CTSH	4
GO:0071813	lipoprotein particle binding	1/313	31/18367	0.413320730872018	0.567641525949561	APOE	1
GO:0071814	protein-lipid complex binding	1/313	31/18367	0.413320730872018	0.567641525949561	APOE	1
GO:0140318	protein transporter activity	1/313	31/18367	0.413320730872018	0.567641525949561	MCL1	1
GO:0001540	amyloid-beta binding	2/313	84/18367	0.420580647159613	0.573903266474037	APOE/C1QA	2
GO:0020037	heme binding	3/313	139/18367	0.423291827815722	0.573903266474037	SDHD/HBA2/HBA1	3
GO:0001222	transcription corepressor binding	1/313	32/18367	0.423335489338263	0.573903266474037	STAT1	1
GO:0050699	WW domain binding	1/313	32/18367	0.423335489338263	0.573903266474037	TCEAL4	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/313	32/18367	0.423335489338263	0.573903266474037	CHD2	1
GO:0008013	beta-catenin binding	2/313	85/18367	0.426453956962782	0.576644682165613	KLF4/NR4A2	2
GO:0016829	lyase activity	4/313	196/18367	0.429533154472517	0.579319075006523	RNASET2/RSAD2/HMGB1/ALDOA	4
GO:0042562	hormone binding	2/313	86/18367	0.43229608524026	0.579777584596722	EGFR/CTSH	2
GO:0001530	lipopolysaccharide binding	1/313	33/18367	0.433179830316563	0.579777584596722	HMGB1	1
GO:0019239	deaminase activity	1/313	33/18367	0.433179830316563	0.579777584596722	APOBEC3A	1
GO:0005253	anion channel activity	2/313	87/18367	0.438106387728913	0.584883147069564	VDAC2/FXYD3	2
GO:0030291	protein serine/threonine kinase inhibitor activity	1/313	34/18367	0.442856644602093	0.586640995057189	PKIB	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/313	34/18367	0.442856644602093	0.586640995057189	CALM1	1
GO:0008276	protein methyltransferase activity	2/313	88/18367	0.443884251012854	0.586640995057189	PRMT9/PCMT1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/313	88/18367	0.443884251012854	0.586640995057189	NCF1/CBR1	2
GO:0003730	mRNA 3'-UTR binding	4/313	201/18367	0.448460256194441	0.591203245008211	ZFP36/CIRBP/HNRNPU/DDX5	4
GO:0005484	SNAP receptor activity	1/313	36/18367	0.461719012691451	0.602640696465764	VAMP2	1
GO:0015248	sterol transporter activity	1/313	36/18367	0.461719012691451	0.602640696465764	APOE	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/313	36/18367	0.461719012691451	0.602640696465764	APOBEC3A	1
GO:0034061	DNA polymerase activity	1/313	36/18367	0.461719012691451	0.602640696465764	PTGES3	1
GO:0046906	tetrapyrrole binding	3/313	149/18367	0.467919751192196	0.609222250314592	SDHD/HBA2/HBA1	3
GO:0005109	frizzled binding	1/313	37/18367	0.470910106959498	0.61009536024802	SDCBP	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/313	37/18367	0.470910106959498	0.61009536024802	ALDH2	1
GO:0004520	endodeoxyribonuclease activity	1/313	38/18367	0.479944757069791	0.618752309359584	DNASE2	1
GO:0140303	intramembrane lipid transporter activity	1/313	38/18367	0.479944757069791	0.618752309359584	PLSCR1	1
GO:0140098	catalytic activity, acting on RNA	7/313	386/18367	0.487437161595492	0.626875176037234	IFIH1/RNASET2/EIF4A2/NT5C3A/DDX24/DDX46/DDX5	7
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	1/313	39/18367	0.488825617511559	0.627127499539219	IQGAP2	1
GO:0042287	MHC protein binding	1/313	40/18367	0.497555297875967	0.636090827596025	PILRA	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	3/313	156/18367	0.498230838345175	0.636090827596025	PRMT9/COMT/PCMT1	3
GO:0004867	serine-type endopeptidase inhibitor activity	2/313	98/18367	0.499764172715631	0.636503522635405	SERPINF1/ITIH5	2
GO:0005496	steroid binding	2/313	100/18367	0.510503583227851	0.648610832796738	VDAC2/GPR183	2
GO:0019894	kinesin binding	1/313	42/18367	0.514571336776337	0.650635872943157	SNCA	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/313	42/18367	0.514571336776337	0.650635872943157	RSAD2	1
GO:0004725	protein tyrosine phosphatase activity	2/313	102/18367	0.521091131143877	0.656386106187485	DUSP1/DUSP2	2
GO:0030547	signaling receptor inhibitor activity	1/313	43/18367	0.522862696753909	0.656386106187485	LY6E	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/313	43/18367	0.522862696753909	0.656386106187485	SNX3	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/313	44/18367	0.531012880988576	0.663450772921593	SGK1	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/313	44/18367	0.531012880988576	0.663450772921593	ALDH2	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1/313	45/18367	0.539024285684891	0.671864394005338	EIF2AK2	1
GO:1902936	phosphatidylinositol bisphosphate binding	2/313	107/18367	0.54688306112095	0.678464656088383	SDCBP/SNX3	2
GO:0140296	general transcription initiation factor binding	1/313	46/18367	0.546899266504704	0.678464656088383	HNRNPU	1
GO:0140097	catalytic activity, acting on DNA	4/313	229/18367	0.549924598569155	0.680612561993825	PTGES3/CHD2/DNASE2/ANXA1	4
GO:0035254	glutamate receptor binding	1/313	47/18367	0.554640139250953	0.683794766226365	CALM1	1
GO:0051020	GTPase binding	5/313	291/18367	0.555095751290224	0.683794766226365	RAB8A/RAC1/GCC2/HSP90AA1/IQGAP2	5
GO:0015026	coreceptor activity	1/313	48/18367	0.562249180539952	0.689377783132901	CXCR4	1
GO:0120013	lipid transfer activity	1/313	48/18367	0.562249180539952	0.689377783132901	APOE	1
GO:0008094	ATP-dependent activity, acting on DNA	2/313	111/18367	0.566808505586854	0.69302383420239	CHD2/ANXA1	2
GO:0016763	pentosyltransferase activity	1/313	49/18367	0.569728628462382	0.69302383420239	TYMP	1
GO:0043539	protein serine/threonine kinase activator activity	1/313	49/18367	0.569728628462382	0.69302383420239	CALM1	1
GO:0004252	serine-type endopeptidase activity	3/313	174/18367	0.571883024954826	0.69302383420239	CFD/SEC11A/CTSH	3
GO:0004721	phosphoprotein phosphatase activity	3/313	174/18367	0.571883024954826	0.69302383420239	DUSP1/DUSP2/PPP4C	3
GO:0004843	thiol-dependent deubiquitinase	2/313	113/18367	0.576532453547761	0.69302383420239	TNFAIP3/OTUD1	2
GO:0000993	RNA polymerase II complex binding	1/313	50/18367	0.577080683233169	0.69302383420239	HNRNPU	1
GO:0005048	signal sequence binding	1/313	50/18367	0.577080683233169	0.69302383420239	NFKBIA	1
GO:0015485	cholesterol binding	1/313	50/18367	0.577080683233169	0.69302383420239	VDAC2	1
GO:0101005	deubiquitinase activity	2/313	114/18367	0.581334458819113	0.69654197115912	TNFAIP3/OTUD1	2
GO:0016860	intramolecular oxidoreductase activity	1/313	51/18367	0.584307507830429	0.698513066179104	PTGES3	1
GO:0004879	nuclear receptor activity	1/313	52/18367	0.591411228623674	0.700635824901019	NR4A2	1
GO:0016830	carbon-carbon lyase activity	1/313	52/18367	0.591411228623674	0.700635824901019	ALDOA	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/313	52/18367	0.591411228623674	0.700635824901019	TNFAIP3	1
GO:0098531	ligand-activated transcription factor activity	1/313	52/18367	0.591411228623674	0.700635824901019	NR4A2	1
GO:0004175	endopeptidase activity	7/313	430/18367	0.601736955894993	0.70905465984952	CASP1/PSMB10/PSMB8/CFD/PSMB9/SEC11A/CTSH	7
GO:0060090	molecular adaptor activity	6/313	369/18367	0.6031173406995	0.70905465984952	KLF4/VAMP2/TRIM22/GRB2/HERPUD1/SDCBP	6
GO:0004197	cysteine-type endopeptidase activity	2/313	119/18367	0.604743300003676	0.70905465984952	CASP1/CTSH	2
GO:0005544	calcium-dependent phospholipid binding	1/313	54/18367	0.605257684928583	0.70905465984952	ANXA1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/313	54/18367	0.605257684928583	0.70905465984952	P4HA1	1
GO:0005179	hormone activity	2/313	122/18367	0.618307537452203	0.722178550568705	METRNL/FBN1	2
GO:0004536	deoxyribonuclease activity	1/313	57/18367	0.625155212816413	0.722178550568705	DNASE2	1
GO:0005548	phospholipid transporter activity	1/313	57/18367	0.625155212816413	0.722178550568705	PLSCR1	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/313	57/18367	0.625155212816413	0.722178550568705	CBR1	1
GO:0043175	RNA polymerase core enzyme binding	1/313	57/18367	0.625155212816413	0.722178550568705	HNRNPU	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	2/313	124/18367	0.62715038342034	0.722178550568705	EIF2AK2/EGFR	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/313	124/18367	0.62715038342034	0.722178550568705	LDHA/CBR1	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/313	125/18367	0.631511982738043	0.722178550568705	APOBEC3A/ASAH1	2
GO:0019783	ubiquitin-like protein-specific protease activity	2/313	125/18367	0.631511982738043	0.722178550568705	TNFAIP3/OTUD1	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/313	58/18367	0.631562990991643	0.722178550568705	MPC2	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/313	58/18367	0.631562990991643	0.722178550568705	SMS	1
GO:0008242	omega peptidase activity	2/313	126/18367	0.635833797546266	0.725484983751271	TNFAIP3/OTUD1	2
GO:0001786	phosphatidylserine binding	1/313	60/18367	0.644052821235397	0.731688518293345	HMGB1	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/313	60/18367	0.644052821235397	0.731688518293345	BLVRA	1
GO:0031267	small GTPase binding	4/313	259/18367	0.646784796527882	0.733208627098418	RAB8A/RAC1/GCC2/IQGAP2	4
GO:0004519	endonuclease activity	2/313	129/18367	0.648561425346632	0.733641526306082	RNASET2/DNASE2	2
GO:0004713	protein tyrosine kinase activity	2/313	136/18367	0.676886479453672	0.762403186707991	EIF2AK2/EGFR	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	2/313	136/18367	0.676886479453672	0.762403186707991	LDHA/CBR1	2
GO:0043022	ribosome binding	1/313	66/18367	0.679046163271219	0.76320145700996	SBDS	1
GO:0051536	iron-sulfur cluster binding	1/313	68/18367	0.689931052940774	0.772135603929462	RSAD2	1
GO:0051540	metal cluster binding	1/313	68/18367	0.689931052940774	0.772135603929462	RSAD2	1
GO:0016791	phosphatase activity	4/313	275/18367	0.692466741353214	0.773136271263034	DUSP1/DUSP2/PPP4C/NT5C3A	4
GO:0004521	endoribonuclease activity	1/313	69/18367	0.695234707808774	0.773136271263034	RNASET2	1
GO:0005518	collagen binding	1/313	69/18367	0.695234707808774	0.773136271263034	FN1	1
GO:0004518	nuclease activity	3/313	210/18367	0.697503094050654	0.774022420824143	PLSCR1/RNASET2/DNASE2	3
GO:0001098	basal transcription machinery binding	1/313	70/18367	0.700447929825161	0.77402439304209	HNRNPU	1
GO:0001099	basal RNA polymerase II transcription machinery binding	1/313	70/18367	0.700447929825161	0.77402439304209	HNRNPU	1
GO:0019199	transmembrane receptor protein kinase activity	2/313	143/18367	0.703329784545619	0.775579594698104	EIF2AK2/EGFR	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/313	71/18367	0.705572256106231	0.776424700234053	ASAH1	1
GO:0008168	methyltransferase activity	3/313	214/18367	0.709583008906126	0.778709245839219	PRMT9/COMT/PCMT1	3
GO:0008235	metalloexopeptidase activity	1/313	72/18367	0.710609197724002	0.778709245839219	LAP3	1
GO:0005254	chloride channel activity	1/313	74/18367	0.720426843668259	0.785296462775332	FXYD3	1
GO:0019905	syntaxin binding	1/313	74/18367	0.720426843668259	0.785296462775332	VAMP2	1
GO:0019842	vitamin binding	2/313	148/18367	0.721099223422976	0.785296462775332	P4HA1/TKT	2
GO:0015103	inorganic anion transmembrane transporter activity	2/313	152/18367	0.734663022924557	0.798414772847763	VDAC2/FXYD3	2
GO:0016741	transferase activity, transferring one-carbon groups	3/313	225/18367	0.740892062980763	0.802239267408331	PRMT9/COMT/PCMT1	3
GO:0005319	lipid transporter activity	2/313	154/18367	0.74123247901226	0.802239267408331	PLSCR1/APOE	2
GO:0016853	isomerase activity	2/313	158/18367	0.753955665254662	0.814334045018382	PTGES3/ISYNA1	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	1/313	82/18367	0.756487130436797	0.815393915183925	SDCBP	1
GO:0140030	modification-dependent protein binding	2/313	160/18367	0.760113169600929	0.817626845010406	TNFAIP3/LAPTM5	2
GO:0043178	alcohol binding	1/313	89/18367	0.784213959384093	0.841829678849046	VDAC2	1
GO:0051213	dioxygenase activity	1/313	92/18367	0.795111421203551	0.851089710188768	P4HA1	1
GO:0019787	ubiquitin-like protein transferase activity	6/313	458/18367	0.796076306868582	0.851089710188768	UBE2B/TNFAIP3/TRIM22/HERC5/UBE2L6/SUMO2	6
GO:0072341	modified amino acid binding	1/313	93/18367	0.798620593579107	0.852077955826796	HMGB1	1
GO:0004896	cytokine receptor activity	1/313	97/18367	0.812068257603475	0.862925057574601	CXCR4	1
GO:0008170	N-methyltransferase activity	1/313	97/18367	0.812068257603475	0.862925057574601	PRMT9	1
GO:0031490	chromatin DNA binding	1/313	103/18367	0.830579743178823	0.880816421193672	HNRNPU	1
GO:1990782	protein tyrosine kinase binding	1/313	105/18367	0.836337033803619	0.885137383864595	HSP90AA1	1
GO:0004842	ubiquitin-protein transferase activity	5/313	433/18367	0.86416471581833	0.911473938086467	UBE2B/TNFAIP3/TRIM22/HERC5/UBE2L6	5
GO:0004540	ribonuclease activity	1/313	116/18367	0.86468725305161	0.911473938086467	RNASET2	1
GO:0042578	phosphoric ester hydrolase activity	4/313	366/18367	0.873475480325014	0.918896205301914	DUSP1/DUSP2/PPP4C/NT5C3A	4
GO:0140101	catalytic activity, acting on a tRNA	1/313	124/18367	0.882178128141094	0.926198992818793	NT5C3A	1
GO:0005085	guanyl-nucleotide exchange factor activity	2/313	223/18367	0.89610864150884	0.937087357655077	SWAP70/TAGAP	2
GO:0005096	GTPase activator activity	5/313	462/18367	0.897851618649514	0.937087357655077	JUN/SWAP70/RGS1/TAGAP/IQGAP2	5
GO:0004674	protein serine/threonine kinase activity	4/313	386/18367	0.897893589844409	0.937087357655077	CCL3/EIF2AK2/EGFR/SGK1	4
GO:0008509	anion transmembrane transporter activity	3/313	314/18367	0.905842252059141	0.943510939768531	MPC2/VDAC2/FXYD3	3
GO:0008528	G protein-coupled peptide receptor activity	1/313	147/18367	0.920885987307789	0.954325000678894	CXCR4	1
GO:0030695	GTPase regulator activity	5/313	488/18367	0.921667491149958	0.954325000678894	JUN/SWAP70/RGS1/TAGAP/IQGAP2	5
GO:0060589	nucleoside-triphosphatase regulator activity	5/313	488/18367	0.921667491149958	0.954325000678894	JUN/SWAP70/RGS1/TAGAP/IQGAP2	5
GO:0001653	peptide receptor activity	1/313	153/18367	0.928699277986314	0.959716739137134	CXCR4	1
GO:0008083	growth factor activity	1/313	162/18367	0.939000460421107	0.966812682183943	TYMP	1
GO:0046943	carboxylic acid transmembrane transporter activity	1/313	163/18367	0.940049230313345	0.966812682183943	MPC2	1
GO:0005342	organic acid transmembrane transporter activity	1/313	164/18367	0.941080025243686	0.966812682183943	MPC2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1/313	170/18367	0.94690415725544	0.970899779174194	P4HA1	1
GO:0008514	organic anion transmembrane transporter activity	1/313	185/18367	0.959074911419354	0.981465765382452	MPC2	1
GO:0008237	metallopeptidase activity	1/313	190/18367	0.962478653043332	0.982075496467277	LAP3	1
GO:0016758	hexosyltransferase activity	1/313	197/18367	0.966774987951349	0.982075496467277	TYMP	1
GO:0061630	ubiquitin protein ligase activity	2/313	304/18367	0.967258795916715	0.982075496467277	TRIM22/HERC5	2
GO:0005244	voltage-gated ion channel activity	1/313	201/18367	0.9690060506968	0.982075496467277	VDAC2	1
GO:0022832	voltage-gated channel activity	1/313	201/18367	0.9690060506968	0.982075496467277	VDAC2	1
GO:0061659	ubiquitin-like protein ligase activity	2/313	316/18367	0.972557091330223	0.983778903922494	TRIM22/HERC5	2
GO:0106310	protein serine kinase activity	2/313	360/18367	0.98577094377989	0.99523131752058	EIF2AK2/SGK1	2
GO:0016757	glycosyltransferase activity	1/313	270/18367	0.990678798818818	0.997801981066781	TYMP	1
GO:0005216	ion channel activity	2/313	432/18367	0.995272966529551	0.997801981066781	VDAC2/FXYD3	2
GO:0022836	gated channel activity	1/313	340/18367	0.99725811239845	0.997801981066781	VDAC2	1
GO:0015267	channel activity	2/313	480/18367	0.997767112122333	0.997801981066781	VDAC2/FXYD3	2
GO:0022803	passive transmembrane transporter activity	2/313	481/18367	0.997801981066781	0.997801981066781	VDAC2/FXYD3	2