ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0050792 regulation of viral process 25/308 164/18722 2.71419989126619e-17 6.20190704517554e-14 HLA-DRB1/PLSCR1/ISG15/IFIT1/MX1/CXCL8/LY6E/ZFP36/IFITM3/TRIM22/OAS1/OAS2/IFIH1/EIF2AK2/CXCR4/BST2/LARP7/STAT1/RSAD2/OAS3/SNX3/DDX5/IFITM1/APOBEC3A/LGALS1 25 GO:0009615 response to virus 35/308 367/18722 4.50822861030113e-17 6.20190704517554e-14 PLSCR1/ISG15/IFI44L/IFIT3/IFIT1/MX1/BNIP3L/CCL4/IFI44/MX2/IFI6/TNFAIP3/IFITM3/NMI/IFIT2/TRIM22/DDIT4/HERC5/OAS1/OAS2/IFIH1/EIF2AK2/GBP1/CXCR4/IFI27/BST2/STAT1/RSAD2/NT5C3A/OAS3/HSP90AA1/IFITM1/APOBEC3A/RPS15A/CXCL10 35 GO:0016032 viral process 37/308 415/18722 4.93997237571562e-17 6.20190704517554e-14 JUN/CCL3/HLA-DRB1/PLSCR1/ISG15/CHMP1B/IFIT1/CHMP5/MX1/HSPA1A/CCL4/CXCL8/LY6E/ZFP36/IFITM3/TRIM22/OAS1/OAS2/IFIH1/EIF2AK2/CXCR4/SSB/HSP90AB1/IFI27/BST2/EGFR/LARP7/STAT1/RSAD2/OAS3/HSPA1B/SNX3/APOE/DDX5/IFITM1/APOBEC3A/LGALS1 37 GO:0051607 defense response to virus 30/308 265/18722 8.11130924035514e-17 6.20190704517554e-14 PLSCR1/ISG15/IFI44L/IFIT3/IFIT1/MX1/BNIP3L/MX2/IFI6/TNFAIP3/IFITM3/IFIT2/TRIM22/DDIT4/HERC5/OAS1/OAS2/IFIH1/EIF2AK2/GBP1/IFI27/BST2/STAT1/RSAD2/NT5C3A/OAS3/HSP90AA1/IFITM1/APOBEC3A/CXCL10 30 GO:0140546 defense response to symbiont 30/308 265/18722 8.11130924035514e-17 6.20190704517554e-14 PLSCR1/ISG15/IFI44L/IFIT3/IFIT1/MX1/BNIP3L/MX2/IFI6/TNFAIP3/IFITM3/IFIT2/TRIM22/DDIT4/HERC5/OAS1/OAS2/IFIH1/EIF2AK2/GBP1/IFI27/BST2/STAT1/RSAD2/NT5C3A/OAS3/HSP90AA1/IFITM1/APOBEC3A/CXCL10 30 GO:0002181 cytoplasmic translation 23/308 148/18722 3.41217426320864e-16 2.17412370137444e-13 RPL39/RPS29/RPL37A/RPLP2/RPS28/RPL36/RPS12/RPLP1/RPS10/EIF4A2/RPL36A/RPS27/RPL3/RPL12/EIF3E/RPL17/RPL37/RPL18A/UBA52/RPS15/RPL34/RPS15A/RPS26 23 GO:0048525 negative regulation of viral process 19/308 92/18722 5.7009453761306e-16 3.11353059613532e-13 PLSCR1/ISG15/IFIT1/MX1/LY6E/ZFP36/IFITM3/OAS1/OAS2/IFIH1/EIF2AK2/BST2/LARP7/STAT1/RSAD2/OAS3/SNX3/IFITM1/APOBEC3A 19 GO:0019058 viral life cycle 30/308 317/18722 1.0931681403753e-14 5.22397725081848e-12 HLA-DRB1/PLSCR1/ISG15/CHMP1B/IFIT1/CHMP5/MX1/HSPA1A/CXCL8/LY6E/IFITM3/TRIM22/OAS1/OAS2/IFIH1/EIF2AK2/CXCR4/HSP90AB1/IFI27/BST2/EGFR/RSAD2/OAS3/HSPA1B/SNX3/APOE/DDX5/IFITM1/APOBEC3A/LGALS1 30 GO:1903900 regulation of viral life cycle 21/308 148/18722 4.44159616443143e-14 1.88669134851348e-11 HLA-DRB1/PLSCR1/ISG15/IFIT1/MX1/CXCL8/LY6E/IFITM3/TRIM22/OAS1/OAS2/IFIH1/EIF2AK2/BST2/RSAD2/OAS3/SNX3/DDX5/IFITM1/APOBEC3A/LGALS1 21 GO:0045071 negative regulation of viral genome replication 14/308 56/18722 2.47183314087745e-13 9.4498180975745e-11 PLSCR1/ISG15/IFIT1/MX1/IFITM3/OAS1/OAS2/IFIH1/EIF2AK2/BST2/RSAD2/OAS3/IFITM1/APOBEC3A 14 GO:0045069 regulation of viral genome replication 16/308 85/18722 5.5239021410543e-13 1.91980708047733e-10 PLSCR1/ISG15/IFIT1/MX1/CXCL8/IFITM3/OAS1/OAS2/IFIH1/EIF2AK2/BST2/RSAD2/OAS3/DDX5/IFITM1/APOBEC3A 16 GO:0019079 viral genome replication 17/308 131/18722 5.26976101546209e-11 1.67885803017596e-08 PLSCR1/ISG15/IFIT1/MX1/CXCL8/IFITM3/OAS1/OAS2/IFIH1/EIF2AK2/IFI27/BST2/RSAD2/OAS3/DDX5/IFITM1/APOBEC3A 17 GO:0002237 response to molecule of bacterial origin 27/308 363/18722 6.98656053570585e-11 2.05458622523104e-08 JUND/B2M/NFKBIA/JUN/FOS/CCL3/SNCA/CHMP5/CEBPB/IRF8/HMGB2/CXCL8/ZFP36/CASP1/TNFAIP3/IL1B/SOD2/COMT/PRDX3/PTGER4/TRIB1/S100A8/CXCL2/HMGB1/CXCL3/S100A9/CXCL10 27 GO:0032496 response to lipopolysaccharide 26/308 343/18722 1.05591997700726e-10 2.88341576578483e-08 JUND/NFKBIA/JUN/FOS/CCL3/SNCA/CHMP5/CEBPB/IRF8/HMGB2/CXCL8/ZFP36/CASP1/TNFAIP3/IL1B/SOD2/COMT/PRDX3/PTGER4/TRIB1/S100A8/CXCL2/HMGB1/CXCL3/S100A9/CXCL10 26 GO:0019221 cytokine-mediated signaling pathway 30/308 472/18722 2.77781380798018e-10 7.07972145860549e-08 NFKBIA/CCL3/CCL3L3/ISG15/TMSB4X/MX1/HSPA1A/CCL4/CXCL8/CASP1/TNFAIP3/IFITM3/IL1B/NMI/OAS1/OAS2/EGR1/CXCR4/HSP90AB1/IFI27/TNFSF13B/STAT1/OAS3/KRT8/HSPA1B/CXCL2/CXCL3/LAPTM5/IFITM1/CXCL10 30 GO:1903706 regulation of hemopoiesis 25/308 367/18722 2.25211797166767e-09 5.14673912005279e-07 B2M/NFKBIA/JUN/FOS/HLA-B/CCL3/HLA-DRB1/ISG15/CEBPB/HSPA1A/HLA-DRA/CD83/HMGB2/ZFP36/NFKBIZ/TRIB1/STAT1/MAFB/TMEM176B/HSPA1B/TMEM176A/HMGB1/C1QC/FBN1/ANXA1 25 GO:0034340 response to type I interferon 11/308 58/18722 2.28863628147783e-09 5.14673912005279e-07 ISG15/IFIT1/MX1/IFITM3/OAS1/OAS2/HSP90AB1/IFI27/STAT1/OAS3/IFITM1 11 GO:0044403 biological process involved in symbiotic interaction 22/308 290/18722 2.98907037799267e-09 5.8681166978793e-07 JUN/CCL3/HLA-DRB1/PLSCR1/IFIT1/HSPA1A/CCL4/CXCL8/SAP30/LY6E/IFITM3/TRIM22/CXCR4/HSP90AB1/IFI27/EGFR/HSPA1B/SNX3/APOE/FN1/IFITM1/LGALS1 22 GO:0002399 MHC class II protein complex assembly 7/308 16/18722 3.06990148986623e-09 5.8681166978793e-07 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0002503 peptide antigen assembly with MHC class II protein complex 7/308 16/18722 3.06990148986623e-09 5.8681166978793e-07 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0001819 positive regulation of cytokine production 28/308 467/18722 4.11444050284526e-09 7.49024097256068e-07 B2M/CCL3/HLA-A/ISG15/CEBPB/HSPA1A/IRF8/CD83/HLA-DPB1/HMGB2/CASP1/IL1B/HLA-F/OAS1/OAS2/IFIH1/EIF2AK2/EGR1/PTGER4/HLA-DPA1/STAT1/RSAD2/OAS3/HSPA1B/HMGB1/HSP90AA1/LAPTM5/ANXA1 28 GO:0048002 antigen processing and presentation of peptide antigen 11/308 62/18722 4.81876721696632e-09 8.37370321384647e-07 B2M/HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HLA-DPA1 11 GO:0000302 response to reactive oxygen species 19/308 222/18722 5.15235173405835e-09 8.56410464317611e-07 JUN/KLF2/FOS/KLF4/DUSP1/RHOB/TNFAIP3/NCF1/SOD2/PRDX3/EGFR/STAT1/LDHA/HBA2/APOE/HBA1/PRDX1/ANXA1/TXNIP 19 GO:0050727 regulation of inflammatory response 25/308 386/18722 6.26433354670127e-09 9.97856131209956e-07 NFKBIA/CCL3/HLA-DRB1/KLF4/SNCA/TMSB4X/CEBPB/ZFP36/CASP1/NUPR1/TNFAIP3/NCF1/NFKBIZ/IL1B/NMI/PTGER4/EGFR/SOCS3/SERPINF1/METRNL/S100A8/APOE/NEAT1/S100A9/ANXA1 25 GO:0002501 peptide antigen assembly with MHC protein complex 7/308 18/18722 8.30164516753396e-09 1.23842425155211e-06 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0002478 antigen processing and presentation of exogenous peptide antigen 9/308 38/18722 8.42245109609074e-09 1.23842425155211e-06 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HLA-DPA1 9 GO:0071357 cellular response to type I interferon 10/308 52/18722 1.07779119337543e-08 1.52607249343491e-06 ISG15/IFIT1/IFITM3/OAS1/OAS2/HSP90AB1/IFI27/STAT1/OAS3/IFITM1 10 GO:0034341 response to interferon-gamma 15/308 141/18722 1.18262011627243e-08 1.59821918546847e-06 CCL3/CCL3L3/SNCA/IRF8/CCL4/GBP4/CASP1/IFITM3/NMI/GBP1/HSP90AB1/HLA-DPA1/BST2/STAT1/IFITM1 15 GO:0045637 regulation of myeloid cell differentiation 18/308 210/18722 1.28444869802825e-08 1.59821918546847e-06 B2M/NFKBIA/JUN/FOS/CCL3/HLA-DRB1/ISG15/CEBPB/HSPA1A/HMGB2/ZFP36/TRIB1/STAT1/MAFB/HSPA1B/HMGB1/C1QC/FBN1 18 GO:0002396 MHC protein complex assembly 7/308 19/18722 1.29596638110182e-08 1.59821918546847e-06 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0002483 antigen processing and presentation of endogenous peptide antigen 7/308 19/18722 1.29596638110182e-08 1.59821918546847e-06 B2M/HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 7 GO:0019882 antigen processing and presentation 13/308 106/18722 2.03129764626225e-08 2.42676590676893e-06 B2M/HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HLA-DPA1/PSMB8/CTSH 13 GO:0030099 myeloid cell differentiation 24/308 381/18722 2.17165938200716e-08 2.51583449012526e-06 B2M/NFKBIA/JUN/KLF2/FOS/CCL3/HLA-DRB1/ISG15/JUNB/CEBPB/HSPA1A/IRF8/HMGB2/ZFP36/GPR183/PRDX3/TRIB1/STAT1/MAFB/HSPA1B/DNASE2/HMGB1/C1QC/FBN1 24 GO:0006979 response to oxidative stress 26/308 446/18722 2.67426854210915e-08 3.00697901073037e-06 JUN/KLF2/FOS/KLF4/SNCA/DUSP1/HSPA1A/RHOB/TNFAIP3/NCF1/SOD2/PRDX3/HNRNPM/EGFR/STAT1/LDHA/HBA2/MCL1/NR4A2/HSPA1B/BTG1/APOE/HBA1/PRDX1/ANXA1/TXNIP 26 GO:0035455 response to interferon-alpha 7/308 21/18722 2.90729785396199e-08 3.1755999130562e-06 IFIT3/MX2/IFITM3/IFIT2/EIF2AK2/BST2/IFITM1 7 GO:0042110 T cell activation 27/308 487/18722 4.04269797162562e-08 4.29312065153466e-06 B2M/HLA-A/HLA-DRB1/HLA-DQA1/CEBPB/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/CD48/NFKBIZ/IL1B/GPR183/PSMB10/EGR1/PTGER4/HLA-DPA1/APBB1IP/TNFSF13B/MAFB/RSAD2/HMGB1/HSPH1/LAPTM5/HES1/LGALS1/ANXA1 27 GO:0032069 regulation of nuclease activity 7/308 22/18722 4.20418320502684e-08 4.34394388995071e-06 HSPA1A/HMGB2/OAS1/OAS2/OAS3/NPM1/HMGB1 7 GO:0032103 positive regulation of response to external stimulus 25/308 427/18722 4.60496967794103e-08 4.63284186283383e-06 NFKBIA/CCL3/SNCA/PLSCR1/TMSB4X/CEBPB/CCL4/HMGB2/CXCL8/SWAP70/NUPR1/NFKBIZ/IL1B/NMI/HLA-F/CXCR4/PTGER4/EGFR/S100A8/RAC1/HMGB1/NEAT1/HSP90AA1/S100A9/CXCL10 25 GO:0071356 cellular response to tumor necrosis factor 18/308 229/18722 4.91351865551577e-08 4.81650815898379e-06 NFKBIA/KLF2/CCL3/CCL3L3/TMSB4X/HSPA1A/CCL4/CXCL8/ZFP36/CASP1/TNFAIP3/GBP1/TNFSF13B/STAT1/KRT8/HSPA1B/LAPTM5/ASAH1 18 GO:0019884 antigen processing and presentation of exogenous antigen 9/308 47/18722 6.18279817542893e-08 5.88186828829897e-06 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-F/HLA-DPA1 9 GO:0002683 negative regulation of immune system process 25/308 434/18722 6.308046032442e-08 5.88186828829897e-06 HLA-B/CCL3/HLA-A/HLA-DRB1/DUSP1/ISG15/CEBPB/TSC22D3/TNFAIP3/NMI/HLA-F/OAS1/GBP1/PTGER4/BST2/TRIB1/MAFB/OAS3/TMEM176B/TMEM176A/HMGB1/C1QC/LAPTM5/FBN1/ANXA1 25 GO:0060337 type I interferon signaling pathway 9/308 50/18722 1.08865532991205e-07 9.90935553869949e-06 ISG15/IFITM3/OAS1/OAS2/HSP90AB1/IFI27/STAT1/OAS3/IFITM1 9 GO:0050870 positive regulation of T cell activation 17/308 216/18722 1.14303624011415e-07 1.01623896417591e-05 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 17 GO:2001233 regulation of apoptotic signaling pathway 22/308 356/18722 1.19481928198632e-07 1.03813502614402e-05 HSPA1A/HMGB2/NUPR1/IFI6/TNFAIP3/IL1B/VDAC2/SOD2/ATF3/TXNDC12/BID/HERPUD1/MCL1/NR4A2/HSPA1B/S100A8/TNFSF10/TIMP3/DNAJA1/CTSH/UBB/S100A9 22 GO:0042542 response to hydrogen peroxide 14/308 146/18722 1.36117517097754e-07 1.15639392858825e-05 JUN/KLF2/KLF4/DUSP1/RHOB/TNFAIP3/SOD2/PRDX3/STAT1/LDHA/HBA2/HBA1/ANXA1/TXNIP 14 GO:0071216 cellular response to biotic stimulus 18/308 246/18722 1.4554554754399e-07 1.20961006143625e-05 NFKBIA/CCL3/CHMP5/CEBPB/IRF8/HMGB2/CXCL8/ZFP36/CASP1/TNFAIP3/IL1B/BID/TRIB1/CXCL2/HMGB1/CXCL3/TXNIP/CXCL10 18 GO:0019883 antigen processing and presentation of endogenous antigen 7/308 26/18722 1.53247526292514e-07 1.24652190003464e-05 B2M/HLA-C/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 7 GO:0043484 regulation of RNA splicing 14/308 148/18722 1.61341309951208e-07 1.28501630821556e-05 SRSF5/HSPA1A/NCL/SRSF4/SRSF9/SRSF3/CIRBP/LARP7/HNRNPA1/SAP18/NPM1/HNRNPU/DDX5/RPS26 14 GO:0032728 positive regulation of interferon-beta production 8/308 39/18722 1.93486672593688e-07 1.50959091699116e-05 ISG15/HMGB2/OAS1/OAS2/IFIH1/OAS3/HMGB1/HSP90AA1 8 GO:0052547 regulation of peptidase activity 25/308 461/18722 1.99449400888823e-07 1.52499011919594e-05 FBLN1/KLF4/SNCA/CASP1/ANP32B/IFI6/PRDX3/BST2/BID/HERPUD1/PSMB8/SERPINF1/PSME2/S100A8/DNAJB6/PSMB9/TNFSF10/TIMP3/HMGB1/ITIH5/FN1/CTSH/RPS27L/LAPTM5/S100A9 25 GO:0034612 response to tumor necrosis factor 18/308 253/18722 2.21403540813718e-07 1.65965830692322e-05 NFKBIA/KLF2/CCL3/CCL3L3/TMSB4X/HSPA1A/CCL4/CXCL8/ZFP36/CASP1/TNFAIP3/GBP1/TNFSF13B/STAT1/KRT8/HSPA1B/LAPTM5/ASAH1 18 GO:0007159 leukocyte cell-cell adhesion 22/308 371/18722 2.43767295566529e-07 1.79215840567469e-05 B2M/HLA-A/HLA-DRB1/HLA-DQA1/KLF4/CEBPB/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/S100A8/HMGB1/HSPH1/LAPTM5/HES1/S100A9/LGALS1/ANXA1 22 GO:0045862 positive regulation of proteolysis 22/308 372/18722 2.55279284896073e-07 1.84138246444847e-05 FBLN1/SNCA/HSPA1A/CASP1/ANP32B/NUPR1/IL1B/BID/TRIB1/HERPUD1/PSME2/SUMO2/HSPA1B/S100A8/TNFSF10/APOE/HMGB1/FN1/CTSH/RPS27L/LAPTM5/S100A9 22 GO:0009266 response to temperature stimulus 15/308 178/18722 2.66311004475667e-07 1.88538327798236e-05 NFKBIA/FOS/HSPA1A/IER5/SOD2/CXCR4/HSP90AB1/CIRBP/IGFBP7/METRNL/HSPA1B/DNAJB6/DNAJA1/HSP90AA1/CXCL10 15 GO:0030595 leukocyte chemotaxis 17/308 230/18722 2.81394672793485e-07 1.95594878925363e-05 CCL3/CCL3L3/DUSP1/CCL4/CXCL8/SWAP70/GPR183/SBDS/CXCR4/S100A8/RAC1/CXCL2/HMGB1/CXCL3/S100A9/ANXA1/CXCL10 17 GO:0032608 interferon-beta production 9/308 56/18722 3.01910422373493e-07 2.02491849953309e-05 ISG15/HMGB2/NMI/OAS1/OAS2/IFIH1/OAS3/HMGB1/HSP90AA1 9 GO:0032648 regulation of interferon-beta production 9/308 56/18722 3.01910422373493e-07 2.02491849953309e-05 ISG15/HMGB2/NMI/OAS1/OAS2/IFIH1/OAS3/HMGB1/HSP90AA1 9 GO:0097193 intrinsic apoptotic signaling pathway 19/308 288/18722 3.28038500673894e-07 2.14446048884132e-05 PPP1R15A/CEBPB/HSPA1A/NUPR1/IFI6/VDAC2/SOD2/DDIT4/TXNDC12/BID/HERPUD1/BCL2A1/MCL1/S100A8/DNAJA1/DDX5/RPS27L/UBB/S100A9 19 GO:0045936 negative regulation of phosphate metabolic process 24/308 441/18722 3.30952573480612e-07 2.14446048884132e-05 PPP1R15A/FBLN1/GADD45B/SNCA/DUSP1/UBE2B/SWAP70/ENSA/NUPR1/TNFAIP3/IL1B/DDIT4/PRDX3/TRIB1/SOCS3/MYADM/NPM1/APOE/MLLT1/DNAJA1/HNRNPU/PKIB/CALM1/APOC1 24 GO:0010563 negative regulation of phosphorus metabolic process 24/308 442/18722 3.44808750321298e-07 2.1970064207972e-05 PPP1R15A/FBLN1/GADD45B/SNCA/DUSP1/UBE2B/SWAP70/ENSA/NUPR1/TNFAIP3/IL1B/DDIT4/PRDX3/TRIB1/SOCS3/MYADM/NPM1/APOE/MLLT1/DNAJA1/HNRNPU/PKIB/CALM1/APOC1 24 GO:2000116 regulation of cysteine-type endopeptidase activity 17/308 235/18722 3.81701757180814e-07 2.39220625852828e-05 KLF4/SNCA/CASP1/ANP32B/IFI6/PRDX3/BID/HERPUD1/S100A8/DNAJB6/PSMB9/TNFSF10/HMGB1/CTSH/RPS27L/LAPTM5/S100A9 17 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 16/308 209/18722 3.94564710078052e-07 2.39431886766412e-05 KLF4/SNCA/CASP1/ANP32B/IFI6/PRDX3/BID/HERPUD1/S100A8/DNAJB6/TNFSF10/HMGB1/CTSH/RPS27L/LAPTM5/S100A9 16 GO:0071222 cellular response to lipopolysaccharide 16/308 209/18722 3.94564710078052e-07 2.39431886766412e-05 NFKBIA/CCL3/CHMP5/CEBPB/IRF8/HMGB2/CXCL8/ZFP36/CASP1/TNFAIP3/IL1B/TRIB1/CXCL2/HMGB1/CXCL3/CXCL10 16 GO:0032481 positive regulation of type I interferon production 9/308 58/18722 4.12312959449501e-07 2.46292569371163e-05 ISG15/HMGB2/OAS1/OAS2/IFIH1/STAT1/OAS3/HMGB1/HSP90AA1 9 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 7/308 30/18722 4.48237316183932e-07 2.60942514620107e-05 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0032479 regulation of type I interferon production 11/308 95/18722 4.57314896143008e-07 2.60942514620107e-05 ISG15/IRF8/HMGB2/NMI/OAS1/OAS2/IFIH1/STAT1/OAS3/HMGB1/HSP90AA1 11 GO:0032606 type I interferon production 11/308 95/18722 4.57314896143008e-07 2.60942514620107e-05 ISG15/IRF8/HMGB2/NMI/OAS1/OAS2/IFIH1/STAT1/OAS3/HMGB1/HSP90AA1 11 GO:1903039 positive regulation of leukocyte cell-cell adhesion 17/308 239/18722 4.84241364597254e-07 2.72243343655191e-05 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 17 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 21/308 356/18722 5.01781138603286e-07 2.78015839547879e-05 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/TNFAIP3/NFKBIZ/IL1B/HLA-F/HLA-DPA1/TNFSF13B/RSAD2/HMGB1/C1QC/CTSH/ANXA1/C1QA 21 GO:0001818 negative regulation of cytokine production 21/308 357/18722 5.25301459525456e-07 2.86889639966545e-05 KLF2/HLA-DRB1/KLF4/TMSB4X/CD83/SRGN/ZFP36/TNFAIP3/NMI/HLA-F/OAS1/GBP1/PTGER4/HSP90AB1/BST2/OAS3/RAC1/HMGB1/FN1/LAPTM5/ANXA1 21 GO:0002831 regulation of response to biotic stimulus 20/308 327/18722 5.3521424545932e-07 2.88186487379011e-05 HLA-B/HLA-A/HLA-DRB1/PLSCR1/ISG15/IFIT1/HMGB2/TNFAIP3/NCF1/NMI/HERC5/HLA-F/OAS1/HSP90AB1/TRIB1/STAT1/OAS3/APOE/HMGB1/HSP90AA1 20 GO:0042176 regulation of protein catabolic process 22/308 391/18722 5.94719642852351e-07 3.15779610364519e-05 SNCA/HSPA1A/GABARAPL2/NUPR1/TNFAIP3/IL1B/HSP90AB1/EEF1A1/EGFR/TRIB1/HERPUD1/SDCBP/PSME2/SUMO2/HSPA1B/SNX3/APOE/OAZ1/TIMP3/HSP90AA1/LAPTM5/UBB 22 GO:0050729 positive regulation of inflammatory response 13/308 142/18722 6.54480636683626e-07 3.42750612882397e-05 NFKBIA/CCL3/SNCA/CEBPB/NUPR1/NFKBIZ/IL1B/NMI/PTGER4/EGFR/S100A8/NEAT1/S100A9 13 GO:0035456 response to interferon-beta 7/308 32/18722 7.20463921648379e-07 3.72207239521859e-05 XAF1/PLSCR1/IFITM3/OAS1/BST2/STAT1/IFITM1 7 GO:0097529 myeloid leukocyte migration 16/308 220/18722 7.85408095705361e-07 4.0034868665088e-05 CCL3/CCL3L3/DUSP1/CCL4/CXCL8/SWAP70/PTGER4/S100A8/RAC1/CXCL2/HMGB1/CXCL3/CD9/S100A9/ANXA1/CXCL10 16 GO:1903037 regulation of leukocyte cell-cell adhesion 20/308 336/18722 8.19402952690632e-07 4.12181248438985e-05 B2M/HLA-A/HLA-DRB1/HLA-DQA1/KLF4/CEBPB/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/LAPTM5/HES1/LGALS1/ANXA1 20 GO:0071219 cellular response to molecule of bacterial origin 16/308 221/18722 8.34297948127104e-07 4.14223513725963e-05 NFKBIA/CCL3/CHMP5/CEBPB/IRF8/HMGB2/CXCL8/ZFP36/CASP1/TNFAIP3/IL1B/TRIB1/CXCL2/HMGB1/CXCL3/CXCL10 16 GO:0048024 regulation of mRNA splicing, via spliceosome 11/308 101/18722 8.52922569623944e-07 4.14600037368976e-05 NCL/SRSF4/SRSF9/SRSF3/CIRBP/LARP7/HNRNPA1/SAP18/NPM1/HNRNPU/DDX5 11 GO:0052548 regulation of endopeptidase activity 23/308 432/18722 8.56746088206882e-07 4.14600037368976e-05 KLF4/SNCA/CASP1/ANP32B/IFI6/PRDX3/BST2/BID/HERPUD1/PSMB8/SERPINF1/PSME2/S100A8/DNAJB6/PSMB9/TNFSF10/TIMP3/HMGB1/ITIH5/CTSH/RPS27L/LAPTM5/S100A9 23 GO:0045646 regulation of erythrocyte differentiation 8/308 47/18722 8.82164638192693e-07 4.16664764899919e-05 B2M/ISG15/HSPA1A/HMGB2/ZFP36/STAT1/MAFB/HSPA1B 8 GO:0031349 positive regulation of defense response 18/308 278/18722 8.82810514174559e-07 4.16664764899919e-05 NFKBIA/CCL3/SNCA/PLSCR1/CEBPB/HMGB2/NUPR1/NFKBIZ/IL1B/NMI/HLA-F/PTGER4/EGFR/S100A8/HMGB1/NEAT1/HSP90AA1/S100A9 18 GO:0060326 cell chemotaxis 19/308 310/18722 1.00222366795605e-06 4.67256229584876e-05 CCL3/CCL3L3/DUSP1/TMSB4X/CCL4/HMGB2/CXCL8/SWAP70/GPR183/SBDS/CXCR4/S100A8/RAC1/CXCL2/HMGB1/CXCL3/S100A9/ANXA1/CXCL10 19 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 7/308 34/18722 1.11948068462869e-06 5.15635500883791e-05 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0052372 modulation by symbiont of entry into host 8/308 49/18722 1.22955337463406e-06 5.59593160860241e-05 HLA-DRB1/CXCL8/LY6E/IFITM3/TRIM22/SNX3/IFITM1/LGALS1 8 GO:0044409 entry into host 13/308 151/18722 1.31998200776822e-06 5.93681319493871e-05 HLA-DRB1/PLSCR1/HSPA1A/CXCL8/LY6E/IFITM3/TRIM22/CXCR4/EGFR/HSPA1B/SNX3/IFITM1/LGALS1 13 GO:2001198 regulation of dendritic cell differentiation 5/308 13/18722 1.34741545973019e-06 5.98973174714943e-05 HLA-B/CEBPB/TMEM176B/TMEM176A/HMGB1 5 GO:0022407 regulation of cell-cell adhesion 23/308 448/18722 1.59423184218166e-06 7.00545785363274e-05 B2M/HLA-A/HLA-DRB1/HLA-DQA1/KLF4/CEBPB/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/SWAP70/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/MYADM/HMGB1/HSPH1/LAPTM5/CD9/HES1/LGALS1/ANXA1 23 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 7/308 36/18722 1.68882477091517e-06 7.33679215819172e-05 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/HLA-DPA1 7 GO:0002262 myeloid cell homeostasis 13/308 157/18722 2.04834222051207e-06 8.79866551575014e-05 B2M/KLF2/ISG15/HSPA1A/HMGB2/ZFP36/STAT1/MAFB/HSPA1B/DNASE2/HMGB1/PRDX1/ANXA1 13 GO:0002819 regulation of adaptive immune response 14/308 183/18722 2.13194877533538e-06 9.05604463123018e-05 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/CD48/TNFAIP3/NFKBIZ/IL1B/HLA-F/TNFSF13B/RSAD2/HMGB1/ANXA1 14 GO:0051348 negative regulation of transferase activity 17/308 268/18722 2.3571624538037e-06 9.9026725943863e-05 GADD45B/SNCA/DUSP1/ZFP36/TNFAIP3/IL1B/PRDX3/TRIB1/EIF4A2/NPM1/APOE/MLLT1/DNAJA1/HNRNPU/PKIB/RPL37/RPS15 17 GO:0050863 regulation of T cell activation 19/308 329/18722 2.42131534230044e-06 0.000100616179930593 B2M/HLA-A/HLA-DRB1/HLA-DQA1/CEBPB/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/LAPTM5/HES1/LGALS1/ANXA1 19 GO:1903131 mononuclear cell differentiation 22/308 426/18722 2.45491663725821e-06 0.000100915551658475 B2M/JUN/HLA-B/HLA-DRB1/KLF6/CEBPB/IRF8/HLA-DRA/CD83/NFKBIZ/IL1B/GPR183/EGR1/PTGER4/TNFSF13B/MAFB/RSAD2/TMEM176B/TMEM176A/HMGB1/LGALS1/ANXA1 22 GO:0048872 homeostasis of number of cells 17/308 272/18722 2.88057279096353e-06 0.000117153508296315 B2M/KLF2/ISG15/HSPA1A/HMGB2/TSC22D3/ZFP36/TNFAIP3/GPR183/TNFSF13B/STAT1/MAFB/HSPA1B/DNASE2/HMGB1/PRDX1/ANXA1 17 GO:0045088 regulation of innate immune response 15/308 218/18722 3.46194293384317e-06 0.000139315871958763 HLA-B/HLA-A/PLSCR1/ISG15/HMGB2/TNFAIP3/NCF1/NMI/HLA-F/OAS1/HSP90AB1/OAS3/APOE/HMGB1/HSP90AA1 15 GO:0002711 positive regulation of T cell mediated immunity 8/308 56/18722 3.50490760863689e-06 0.000139575643623113 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2 8 GO:0071346 cellular response to interferon-gamma 11/308 118/18722 4.00866102377387e-06 0.000157990836019459 CCL3/CCL3L3/IRF8/CCL4/GBP4/CASP1/NMI/GBP1/HSP90AB1/HLA-DPA1/STAT1 11 GO:1902105 regulation of leukocyte differentiation 17/308 279/18722 4.05356961747381e-06 0.000158130578036759 JUN/FOS/HLA-B/CCL3/HLA-DRB1/CEBPB/HLA-DRA/CD83/NFKBIZ/TRIB1/MAFB/TMEM176B/TMEM176A/HMGB1/C1QC/FBN1/ANXA1 17 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 13/308 168/18722 4.35081873067416e-06 0.000168011919266337 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/TNFAIP3/NFKBIZ/IL1B/HLA-F/TNFSF13B/RSAD2/HMGB1/ANXA1 13 GO:0002696 positive regulation of leukocyte activation 21/308 409/18722 4.56730315703164e-06 0.000173987447233062 JUND/B2M/CCL3/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/GPR183/HLA-F/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 21 GO:0042743 hydrogen peroxide metabolic process 8/308 58/18722 4.59658178669611e-06 0.000173987447233062 SNCA/SOD2/PRDX3/EGFR/HBA2/RAC1/HBA1/PRDX1 8 GO:0046718 viral entry into host cell 12/308 144/18722 4.74664599042345e-06 0.000177906153150871 HLA-DRB1/PLSCR1/HSPA1A/LY6E/IFITM3/TRIM22/CXCR4/EGFR/HSPA1B/SNX3/IFITM1/LGALS1 12 GO:0046596 regulation of viral entry into host cell 7/308 42/18722 5.01560870807336e-06 0.000185819267347244 HLA-DRB1/LY6E/IFITM3/TRIM22/SNX3/IFITM1/LGALS1 7 GO:0010952 positive regulation of peptidase activity 14/308 197/18722 5.05498399270557e-06 0.000185819267347244 FBLN1/SNCA/CASP1/ANP32B/BID/PSME2/S100A8/TNFSF10/HMGB1/FN1/CTSH/RPS27L/LAPTM5/S100A9 14 GO:0022409 positive regulation of cell-cell adhesion 17/308 284/18722 5.13780708597238e-06 0.000187065109425452 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 17 GO:0033209 tumor necrosis factor-mediated signaling pathway 10/308 99/18722 5.36809626882718e-06 0.000193605962601192 NFKBIA/TMSB4X/HSPA1A/CASP1/TNFAIP3/TNFSF13B/STAT1/KRT8/HSPA1B/LAPTM5 10 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 5/308 17/18722 6.1370198605375e-06 0.000214876915354541 B2M/HLA-C/HLA-B/HLA-A/HLA-F 5 GO:1901214 regulation of neuron death 18/308 319/18722 6.16446614014004e-06 0.000214876915354541 JUN/FOS/CCL3/SNCA/CEBPB/NUPR1/SOD2/DDIT4/HLA-F/EGR1/HSP90AB1/SERPINF1/MCL1/NR4A2/SET/APOE/UBB/C1QA 18 GO:0034599 cellular response to oxidative stress 17/308 288/18722 6.18559950690003e-06 0.000214876915354541 JUN/KLF2/FOS/KLF4/SNCA/HSPA1A/RHOB/TNFAIP3/NCF1/SOD2/PRDX3/EGFR/MCL1/NR4A2/HSPA1B/PRDX1/ANXA1 17 GO:0031348 negative regulation of defense response 16/308 258/18722 6.23980099273989e-06 0.000214876915354541 HLA-B/HLA-A/HLA-DRB1/KLF4/ISG15/ZFP36/TNFAIP3/NMI/HLA-F/OAS1/PTGER4/SOCS3/SERPINF1/OAS3/METRNL/APOE 16 GO:0051384 response to glucocorticoid 12/308 148/18722 6.30202794413817e-06 0.000214876915354541 FOSB/FOS/DUSP1/ZFP36/DDIT4/EGFR/IGFBP7/SERPINF1/HMGB1/HNRNPU/CALM1/ANXA1 12 GO:0097530 granulocyte migration 12/308 148/18722 6.30202794413817e-06 0.000214876915354541 CCL3/CCL3L3/CCL4/CXCL8/PTGER4/S100A8/RAC1/CXCL2/CXCL3/S100A9/ANXA1/CXCL10 12 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 18/308 320/18722 6.43600974701416e-06 0.000214876915354541 SRSF5/NCL/SF3B6/SRSF4/SRSF9/SYF2/HNRNPM/BCAS2/SRSF3/CIRBP/LARP7/HNRNPA1/IK/SAP18/DDX46/NPM1/HNRNPU/DDX5 18 GO:0000398 mRNA splicing, via spliceosome 18/308 320/18722 6.43600974701416e-06 0.000214876915354541 SRSF5/NCL/SF3B6/SRSF4/SRSF9/SYF2/HNRNPM/BCAS2/SRSF3/CIRBP/LARP7/HNRNPA1/IK/SAP18/DDX46/NPM1/HNRNPU/DDX5 18 GO:0042326 negative regulation of phosphorylation 20/308 385/18722 6.50411210437921e-06 0.000214876915354541 FBLN1/GADD45B/SNCA/DUSP1/UBE2B/NUPR1/TNFAIP3/IL1B/DDIT4/PRDX3/TRIB1/SOCS3/MYADM/NPM1/APOE/MLLT1/DNAJA1/HNRNPU/PKIB/CALM1 20 GO:0001916 positive regulation of T cell mediated cytotoxicity 6/308 29/18722 6.51993779260443e-06 0.000214876915354541 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 6 GO:0052126 movement in host environment 13/308 175/18722 6.80717912520778e-06 0.000222426032441618 HLA-DRB1/PLSCR1/HSPA1A/CXCL8/LY6E/IFITM3/TRIM22/CXCR4/EGFR/HSPA1B/SNX3/IFITM1/LGALS1 13 GO:0050867 positive regulation of cell activation 21/308 420/18722 6.87020931048705e-06 0.00022258313723722 JUND/B2M/CCL3/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/GPR183/HLA-F/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 21 GO:0071621 granulocyte chemotaxis 11/308 125/18722 7.01642312066045e-06 0.000225409962943571 CCL3/CCL3L3/CCL4/CXCL8/S100A8/RAC1/CXCL2/CXCL3/S100A9/ANXA1/CXCL10 11 GO:0051701 biological process involved in interaction with host 14/308 203/18722 7.14589488659961e-06 0.000227656301262252 HLA-DRB1/PLSCR1/IFIT1/HSPA1A/CXCL8/LY6E/IFITM3/TRIM22/CXCR4/EGFR/HSPA1B/SNX3/IFITM1/LGALS1 14 GO:0000375 RNA splicing, via transesterification reactions 18/308 324/18722 7.63310989743175e-06 0.000238445963174089 SRSF5/NCL/SF3B6/SRSF4/SRSF9/SYF2/HNRNPM/BCAS2/SRSF3/CIRBP/LARP7/HNRNPA1/IK/SAP18/DDX46/NPM1/HNRNPU/DDX5 18 GO:0030593 neutrophil chemotaxis 10/308 103/18722 7.67168544870858e-06 0.000238445963174089 CCL3/CCL3L3/CCL4/CXCL8/S100A8/RAC1/CXCL2/CXCL3/S100A9/CXCL10 10 GO:0045639 positive regulation of myeloid cell differentiation 10/308 103/18722 7.67168544870858e-06 0.000238445963174089 JUN/FOS/HLA-DRB1/ISG15/HSPA1A/HMGB2/TRIB1/STAT1/HSPA1B/HMGB1 10 GO:0051235 maintenance of location 18/308 326/18722 8.30368751994486e-06 0.000256008043457655 NFKBIA/CCL3/SNCA/FBN2/TMSB4X/PLIN2/SRGN/IL1B/HK2/SRI/S100A8/APOE/HNRNPU/FBN1/CALM1/MEST/S100A9/CXCL10 18 GO:1901673 regulation of mitotic spindle assembly 5/308 18/18722 8.38326199035666e-06 0.000256393684713068 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:0043367 CD4-positive, alpha-beta T cell differentiation 9/308 83/18722 8.88204775797577e-06 0.000269492607767788 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/GPR183/PTGER4/RSAD2/HMGB1/ANXA1 9 GO:0070997 neuron death 19/308 361/18722 9.2265372801224e-06 0.000277740567101637 JUN/FOS/CCL3/SNCA/CEBPB/NUPR1/SOD2/DDIT4/HLA-F/EGR1/HSP90AB1/BID/SERPINF1/MCL1/NR4A2/SET/APOE/UBB/C1QA 19 GO:0034101 erythrocyte homeostasis 11/308 129/18722 9.49741411119423e-06 0.000281462125171283 B2M/KLF2/ISG15/HSPA1A/HMGB2/ZFP36/STAT1/MAFB/HSPA1B/DNASE2/PRDX1 11 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 11/308 129/18722 9.49741411119423e-06 0.000281462125171283 SNCA/CASP1/ANP32B/BID/S100A8/TNFSF10/HMGB1/CTSH/RPS27L/LAPTM5/S100A9 11 GO:0051251 positive regulation of lymphocyte activation 19/308 362/18722 9.59460017727575e-06 0.000282155049828655 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/GPR183/HLA-F/HLA-DPA1/TNFSF13B/HMGB1/HSPH1/HES1/LGALS1/ANXA1 19 GO:0070371 ERK1 and ERK2 cascade 18/308 330/18722 9.80581956217506e-06 0.000286165253329735 CCL3/FBLN1/HLA-DRB1/KLF4/CCL3L3/DUSP1/CCL4/IL1B/GPR183/ATF3/GBP1/PTGER4/EGFR/APOE/TIMP3/HMGB1/FN1/CTSH 18 GO:0034614 cellular response to reactive oxygen species 12/308 155/18722 1.01191197347206e-05 0.000293071172316946 JUN/KLF2/FOS/KLF4/RHOB/TNFAIP3/NCF1/SOD2/PRDX3/EGFR/PRDX1/ANXA1 12 GO:0031396 regulation of protein ubiquitination 14/308 210/18722 1.05271197856096e-05 0.000302595330378839 ISG15/HSPA1A/TNFAIP3/NMI/HSP90AB1/HERPUD1/HSPA1B/NPM1/DNAJA1/RPL37/HSP90AA1/LAPTM5/RPS15/UBB 14 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 10/308 107/18722 1.07841393323878e-05 0.000303897387338386 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/NFKBIZ/IL1B/HLA-F/TNFSF13B/RSAD2 10 GO:0008637 apoptotic mitochondrial changes 10/308 107/18722 1.07841393323878e-05 0.000303897387338386 JUN/HSPA1A/BNIP3L/IFI6/HK2/IFIT2/VDAC2/SOD2/BID/TNFSF10 10 GO:0002709 regulation of T cell mediated immunity 9/308 85/18722 1.08108931933091e-05 0.000303897387338386 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2/HMGB1 9 GO:1903320 regulation of protein modification by small protein conjugation or removal 15/308 242/18722 1.22429393173497e-05 0.000341640562118452 ISG15/HSPA1A/TNFAIP3/NMI/EGR1/HSP90AB1/HERPUD1/HSPA1B/NPM1/DNAJA1/RPL37/HSP90AA1/LAPTM5/RPS15/UBB 15 GO:0045785 positive regulation of cell adhesion 21/308 437/18722 1.2537138686305e-05 0.000345542176653535 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/CD83/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/HLA-DPA1/APBB1IP/TNFSF13B/RAC1/MYADM/HMGB1/HSPH1/FN1/HES1/LGALS1/ANXA1 21 GO:0050900 leukocyte migration 19/308 369/18722 1.25635266949624e-05 0.000345542176653535 CCL3/CCL3L3/DUSP1/CCL4/CXCL8/SWAP70/GPR183/SBDS/CXCR4/PTGER4/S100A8/RAC1/CXCL2/HMGB1/CXCL3/CD9/S100A9/ANXA1/CXCL10 19 GO:0002456 T cell mediated immunity 10/308 109/18722 1.27120871168608e-05 0.000347130778912563 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2/HMGB1/CTSH 10 GO:0062197 cellular response to chemical stress 18/308 337/18722 1.30306077033811e-05 0.000353305058510823 JUN/KLF2/FOS/KLF4/SNCA/HSPA1A/RHOB/TNFAIP3/NCF1/SOD2/PRDX3/EGFR/MCL1/NR4A2/HSPA1B/DNAJA1/PRDX1/ANXA1 18 GO:0002443 leukocyte mediated immunity 21/308 440/18722 1.38919505158321e-05 0.000374006526915678 B2M/HLA-B/CCL3/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/IL1B/VAMP2/HLA-F/HLA-DPA1/BST2/RSAD2/HMGB1/C1QC/CTSH/PRDX1/C1QA 21 GO:0048545 response to steroid hormone 18/308 339/18722 1.41119423708716e-05 0.000377272417369524 FOSB/FOS/YWHAH/DUSP1/HMGB2/ZFP36/DDIT4/PTGES3/EGFR/IGFBP7/SERPINF1/HMGB1/DNAJA1/HNRNPU/DDX5/CALM1/ANXA1/TXNIP 18 GO:0001913 T cell mediated cytotoxicity 7/308 49/18722 1.44721441463456e-05 0.000379170930916298 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F/CTSH 7 GO:0009409 response to cold 7/308 49/18722 1.44721441463456e-05 0.000379170930916298 NFKBIA/FOS/SOD2/CIRBP/METRNL/HSP90AA1/CXCL10 7 GO:0009612 response to mechanical stimulus 14/308 216/18722 1.4480501154533e-05 0.000379170930916298 JUND/NFKBIA/JUN/FOSB/FOS/CASP1/IL1B/CXCR4/PTGER4/EGFR/STAT1/RAC1/TXNIP/CXCL10 14 GO:0010038 response to metal ion 19/308 373/18722 1.46086271483883e-05 0.00037992368427407 JUND/B2M/JUN/FOSB/FOS/SNCA/PLSCR1/DUSP1/AOC1/JUNB/NCF1/SOD2/CACYBP/EGFR/SERPINF1/S100A8/CALM1/TXNIP/C1QA 19 GO:0060759 regulation of response to cytokine stimulus 12/308 162/18722 1.58259742408623e-05 0.000408802023802814 KLF4/ISG15/HSPA1A/CASP1/TNFAIP3/OAS1/IFIH1/CXCR4/HSP90AB1/OAS3/HSPA1B/LAPTM5 12 GO:0002821 positive regulation of adaptive immune response 10/308 112/18722 1.61583714429969e-05 0.000414586939775687 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/NFKBIZ/IL1B/HLA-F/TNFSF13B/RSAD2 10 GO:0050684 regulation of mRNA processing 11/308 137/18722 1.68254862941593e-05 0.000428115935172465 NCL/SRSF4/SRSF9/SRSF3/CIRBP/LARP7/HNRNPA1/SAP18/NPM1/HNRNPU/DDX5 11 GO:0097191 extrinsic apoptotic signaling pathway 14/308 219/18722 1.69096275728596e-05 0.000428115935172465 HSPA1A/HMGB2/IFI6/TNFAIP3/IL1B/ATF3/IFI27/BID/BCL2A1/MCL1/KRT8/HSPA1B/TNFSF10/TIMP3 14 GO:2001242 regulation of intrinsic apoptotic signaling pathway 12/308 164/18722 1.79022589975329e-05 0.000450265369391896 HSPA1A/NUPR1/VDAC2/SOD2/TXNDC12/BID/HERPUD1/MCL1/S100A8/DNAJA1/UBB/S100A9 12 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 8/308 70/18722 1.90836040005357e-05 0.000476840641137569 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/HLA-DPA1 8 GO:0045824 negative regulation of innate immune response 8/308 71/18722 2.1203255964148e-05 0.000523261492646061 HLA-B/HLA-A/ISG15/TNFAIP3/NMI/HLA-F/OAS1/OAS3 8 GO:0031960 response to corticosteroid 12/308 167/18722 2.14617753103931e-05 0.000523261492646061 FOSB/FOS/DUSP1/ZFP36/DDIT4/EGFR/IGFBP7/SERPINF1/HMGB1/HNRNPU/CALM1/ANXA1 12 GO:0006959 humoral immune response 17/308 317/18722 2.1538810693636e-05 0.000523261492646061 RPL39/HLA-A/HLA-DRB1/CD83/HLA-DQB1/CXCL8/IL1B/GPR183/PSMB10/CFD/CXCL2/CXCL3/C1QC/DEFB1/S100A9/CXCL10/C1QA 17 GO:0002449 lymphocyte mediated immunity 18/308 350/18722 2.16265632783402e-05 0.000523261492646061 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/IL1B/HLA-F/HLA-DPA1/RSAD2/HMGB1/C1QC/CTSH/PRDX1/C1QA 18 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 4/308 11/18722 2.16400120738984e-05 0.000523261492646061 HSPA1A/CASP1/HSPA1B/LAPTM5 4 GO:2001234 negative regulation of apoptotic signaling pathway 14/308 224/18722 2.17626412060486e-05 0.000523261492646061 HSPA1A/HMGB2/IFI6/TNFAIP3/IL1B/VDAC2/SOD2/TXNDC12/BID/HERPUD1/MCL1/NR4A2/HSPA1B/DNAJA1 14 GO:1903362 regulation of cellular protein catabolic process 15/308 255/18722 2.26818900199022e-05 0.000541955409663038 HSPA1A/GABARAPL2/NUPR1/TNFAIP3/HSP90AB1/TRIB1/HERPUD1/SDCBP/PSME2/SUMO2/HSPA1B/APOE/HSP90AA1/LAPTM5/UBB 15 GO:0043903 regulation of biological process involved in symbiotic interaction 8/308 72/18722 2.35169213306848e-05 0.000558417330727999 HLA-DRB1/CXCL8/LY6E/IFITM3/TRIM22/SNX3/IFITM1/LGALS1 8 GO:0070555 response to interleukin-1 11/308 143/18722 2.51531799376115e-05 0.000593583993219067 KLF2/CCL3/CCL3L3/SNCA/CEBPB/CCL4/CXCL8/IL1B/GBP1/EGR1/ANXA1 11 GO:0009410 response to xenobiotic stimulus 21/308 462/18722 2.86020029835877e-05 0.000670831027032245 B2M/JUN/FOSB/FOS/SNCA/UBE2B/PLIN2/IL1B/SOD2/COMT/CXCR4/HSP90AB1/EGFR/STAT1/LDHA/CBR1/ADIRF/APOBEC3A/LGALS1/ANXA1/TXNIP 21 GO:0030218 erythrocyte differentiation 10/308 120/18722 2.95224940347611e-05 0.000688198138383486 B2M/KLF2/ISG15/HSPA1A/HMGB2/ZFP36/STAT1/MAFB/HSPA1B/DNASE2 10 GO:1901216 positive regulation of neuron death 9/308 97/18722 3.15895033959618e-05 0.000723153721453665 JUN/FOS/CCL3/SNCA/NUPR1/DDIT4/EGR1/MCL1/C1QA 9 GO:1990868 response to chemokine 9/308 97/18722 3.15895033959618e-05 0.000723153721453665 CCL3/CCL3L3/DUSP1/CCL4/CXCL8/CXCR4/CXCL2/CXCL3/CXCL10 9 GO:1990869 cellular response to chemokine 9/308 97/18722 3.15895033959618e-05 0.000723153721453665 CCL3/CCL3L3/DUSP1/CCL4/CXCL8/CXCR4/CXCL2/CXCL3/CXCL10 9 GO:1990266 neutrophil migration 10/308 122/18722 3.4057855043363e-05 0.000775018927564147 CCL3/CCL3L3/CCL4/CXCL8/S100A8/RAC1/CXCL2/CXCL3/S100A9/CXCL10 10 GO:2001056 positive regulation of cysteine-type endopeptidase activity 11/308 148/18722 3.46083630851693e-05 0.000782886225293504 SNCA/CASP1/ANP32B/BID/S100A8/TNFSF10/HMGB1/CTSH/RPS27L/LAPTM5/S100A9 11 GO:0008380 RNA splicing 20/308 434/18722 3.66198408539719e-05 0.000823515597557262 SRSF5/HSPA1A/NCL/SF3B6/SRSF4/SRSF9/SYF2/HNRNPM/BCAS2/SRSF3/CIRBP/LARP7/HNRNPA1/IK/SAP18/DDX46/NPM1/HNRNPU/DDX5/RPS26 20 GO:0001914 regulation of T cell mediated cytotoxicity 6/308 39/18722 3.89980639840148e-05 0.000866799991923771 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 6 GO:0002347 response to tumor cell 6/308 39/18722 3.89980639840148e-05 0.000866799991923771 HLA-A/HLA-DRB1/KLF4/HMGB1/LAPTM5/TXNIP 6 GO:2001236 regulation of extrinsic apoptotic signaling pathway 11/308 151/18722 4.16395270320609e-05 0.000920161340136236 HSPA1A/HMGB2/IFI6/TNFAIP3/IL1B/ATF3/BID/MCL1/HSPA1B/TNFSF10/TIMP3 11 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 8/308 78/18722 4.23039747544593e-05 0.000929471813139642 SNCA/ANP32B/BID/S100A8/CTSH/RPS27L/LAPTM5/S100A9 8 GO:0010950 positive regulation of endopeptidase activity 12/308 179/18722 4.25954457422744e-05 0.000930527937558372 SNCA/CASP1/ANP32B/BID/PSME2/S100A8/TNFSF10/HMGB1/CTSH/RPS27L/LAPTM5/S100A9 12 GO:0072593 reactive oxygen species metabolic process 14/308 239/18722 4.44377499685254e-05 0.000965258625736777 SNCA/IFI6/NCF1/HK2/SOD2/DDIT4/PRDX3/GRB2/EGFR/HBA2/CBR1/RAC1/HBA1/PRDX1 14 GO:2001235 positive regulation of apoptotic signaling pathway 10/308 126/18722 4.49380273094477e-05 0.000970610612452083 NUPR1/ATF3/BID/MCL1/S100A8/TNFSF10/TIMP3/CTSH/UBB/S100A9 10 GO:0035710 CD4-positive, alpha-beta T cell activation 9/308 102/18722 4.7125733739448e-05 0.000993461206426338 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/GPR183/PTGER4/RSAD2/HMGB1/ANXA1 9 GO:1902106 negative regulation of leukocyte differentiation 9/308 102/18722 4.7125733739448e-05 0.000993461206426338 CCL3/TRIB1/MAFB/TMEM176B/TMEM176A/HMGB1/C1QC/FBN1/ANXA1 9 GO:0033119 negative regulation of RNA splicing 5/308 25/18722 4.72953020061715e-05 0.000993461206426338 SRSF4/SRSF9/SAP18/NPM1/RPS26 5 GO:0090169 regulation of spindle assembly 5/308 25/18722 4.72953020061715e-05 0.000993461206426338 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:1903901 negative regulation of viral life cycle 5/308 25/18722 4.72953020061715e-05 0.000993461206426338 LY6E/IFITM3/BST2/SNX3/IFITM1 5 GO:0002366 leukocyte activation involved in immune response 15/308 275/18722 5.41185862633831e-05 0.00113057571193942 CCL3/HLA-DRB1/IRF8/HLA-DRA/SWAP70/NFKBIZ/VAMP2/NMI/GPR183/HLA-F/PTGER4/APBB1IP/HMGB1/LGALS1/ANXA1 15 GO:0001933 negative regulation of protein phosphorylation 17/308 342/18722 5.5917477970598e-05 0.00115924454116031 FBLN1/GADD45B/SNCA/DUSP1/UBE2B/TNFAIP3/IL1B/DDIT4/TRIB1/SOCS3/MYADM/NPM1/APOE/MLLT1/DNAJA1/PKIB/CALM1 17 GO:0046631 alpha-beta T cell activation 11/308 156/18722 5.60973685887152e-05 0.00115924454116031 HLA-A/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/GPR183/PTGER4/RSAD2/HMGB1/HSPH1/ANXA1 11 GO:0070372 regulation of ERK1 and ERK2 cascade 16/308 309/18722 5.71156124234832e-05 0.00117394078653213 CCL3/FBLN1/HLA-DRB1/KLF4/CCL3L3/DUSP1/CCL4/IL1B/GPR183/ATF3/GBP1/EGFR/APOE/TIMP3/HMGB1/FN1 16 GO:0001892 embryonic placenta development 8/308 82/18722 6.07559375159105e-05 0.00124208528942955 JUNB/CEBPB/PHLDA2/GRB2/SOCS3/KRT8/DNAJB6/HES1 8 GO:0042255 ribosome assembly 7/308 61/18722 6.21034486509372e-05 0.00126288023506666 RPS28/SBDS/RPS27/NPM1/RPL3/RPS27L/RPS15 7 GO:0002263 cell activation involved in immune response 15/308 279/18722 6.37311831974205e-05 0.00128379990097114 CCL3/HLA-DRB1/IRF8/HLA-DRA/SWAP70/NFKBIZ/VAMP2/NMI/GPR183/HLA-F/PTGER4/APBB1IP/HMGB1/LGALS1/ANXA1 15 GO:1903707 negative regulation of hemopoiesis 9/308 106/18722 6.38038140686677e-05 0.00128379990097114 CCL3/TRIB1/MAFB/TMEM176B/TMEM176A/HMGB1/C1QC/FBN1/ANXA1 9 GO:0061136 regulation of proteasomal protein catabolic process 12/308 187/18722 6.51268393006042e-05 0.00130355972066078 HSPA1A/GABARAPL2/NUPR1/HSP90AB1/TRIB1/HERPUD1/SDCBP/PSME2/SUMO2/HSPA1B/APOE/UBB 12 GO:0032623 interleukin-2 production 7/308 62/18722 6.90327428030482e-05 0.00136742059966867 CD83/ZFP36/TNFAIP3/IL1B/GBP1/LAPTM5/ANXA1 7 GO:0032663 regulation of interleukin-2 production 7/308 62/18722 6.90327428030482e-05 0.00136742059966867 CD83/ZFP36/TNFAIP3/IL1B/GBP1/LAPTM5/ANXA1 7 GO:0032102 negative regulation of response to external stimulus 19/308 420/18722 7.32840718469827e-05 0.00144414951892276 HLA-B/HLA-A/HLA-DRB1/KLF4/DUSP1/ISG15/ZFP36/TNFAIP3/NMI/HLA-F/OAS1/PTGER4/TRIB1/SOCS3/SERPINF1/OAS3/METRNL/APOE/CD9 19 GO:0002832 negative regulation of response to biotic stimulus 9/308 108/18722 7.38510587728073e-05 0.00144785947532534 HLA-B/HLA-A/ISG15/TNFAIP3/NMI/HLA-F/OAS1/TRIB1/OAS3 9 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 13/308 221/18722 7.94909148907379e-05 0.00155047840626169 HSPA1A/GABARAPL2/NUPR1/HSP90AB1/TRIB1/HERPUD1/SDCBP/PSME2/SUMO2/HSPA1B/APOE/LAPTM5/UBB 13 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 5/308 28/18722 8.4019628475929e-05 0.00163049258712425 B2M/HLA-C/HLA-B/HLA-A/HLA-F 5 GO:0140374 antiviral innate immune response 4/308 15/18722 8.49682449959192e-05 0.00163671509256933 IFIT1/MX1/OAS1/CXCL10 4 GO:0009408 response to heat 9/308 110/18722 8.51965219516863e-05 0.00163671509256933 HSPA1A/IER5/HSP90AB1/IGFBP7/HSPA1B/DNAJB6/DNAJA1/HSP90AA1/CXCL10 9 GO:0006986 response to unfolded protein 10/308 137/18722 9.12673367980627e-05 0.00174457514289497 PPP1R15A/HSPA1A/ATF3/EIF2AK2/HSP90AB1/HERPUD1/HSPA1B/HSPH1/DNAJA1/HSP90AA1 10 GO:0002285 lymphocyte activation involved in immune response 12/308 194/18722 9.2636253363872e-05 0.00175320988420833 HLA-DRB1/IRF8/HLA-DRA/SWAP70/NFKBIZ/GPR183/HLA-F/PTGER4/APBB1IP/HMGB1/LGALS1/ANXA1 12 GO:1901654 response to ketone 12/308 194/18722 9.2636253363872e-05 0.00175320988420833 FOSB/KLF2/FOS/KLF4/DUSP1/DDIT4/PTGER4/EGFR/IGFBP7/SERPINF1/CALM1/TXNIP 12 GO:0032609 interferon-gamma production 9/308 112/18722 9.79707272791852e-05 0.00181816548732197 HLA-A/HLA-DRB1/ISG15/IRF8/HLA-DPB1/IL1B/HLA-DPA1/HMGB1/LAPTM5 9 GO:0032649 regulation of interferon-gamma production 9/308 112/18722 9.79707272791852e-05 0.00181816548732197 HLA-A/HLA-DRB1/ISG15/IRF8/HLA-DPB1/IL1B/HLA-DPA1/HMGB1/LAPTM5 9 GO:0046632 alpha-beta T cell differentiation 9/308 112/18722 9.79707272791852e-05 0.00181816548732197 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/GPR183/PTGER4/RSAD2/HMGB1/ANXA1 9 GO:1901222 regulation of NIK/NF-kappaB signaling 9/308 112/18722 9.79707272791852e-05 0.00181816548732197 NFKBIA/TMSB4X/IL1B/NMI/EIF2AK2/EGFR/HMGB1/LAPTM5/PRDX1 9 GO:0070098 chemokine-mediated signaling pathway 8/308 88/18722 0.000100629589932664 0.00185848754740374 CCL3/CCL3L3/CCL4/CXCL8/CXCR4/CXCL2/CXCL3/CXCL10 8 GO:0042093 T-helper cell differentiation 7/308 66/18722 0.000103358224141021 0.00189161086824141 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/HMGB1/ANXA1 7 GO:0002764 immune response-regulating signaling pathway 20/308 468/18722 0.00010341267890726 0.00189161086824141 NFKBIA/HLA-A/HLA-DRB1/PLSCR1/HSPA1A/HLA-DPB1/HLA-DQB1/TNFAIP3/NFKBIZ/NMI/OAS1/IFIH1/GBP1/FCGR1B/RSAD2/OAS3/HSPA1B/HMGB1/CTSH/LAPTM5 20 GO:0071347 cellular response to interleukin-1 9/308 113/18722 0.000104936892300807 0.00191035113936184 KLF2/CCL3/CCL3L3/CEBPB/CCL4/CXCL8/IL1B/GBP1/EGR1 9 GO:0071248 cellular response to metal ion 12/308 197/18722 0.000107185100629623 0.00194203146780592 JUND/B2M/JUN/FOSB/FOS/SNCA/AOC1/JUNB/NCF1/CACYBP/EGFR/SERPINF1 12 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 4/308 16/18722 0.000111827319298903 0.00200711662760426 NFKBIA/HSPA1A/TNFAIP3/HSPA1B 4 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 4/308 16/18722 0.000111827319298903 0.00200711662760426 IL1B/OAS1/OAS3/HMGB1 4 GO:0046635 positive regulation of alpha-beta T cell activation 7/308 67/18722 0.000113811380828065 0.00203318181731631 HLA-A/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HSPH1/ANXA1 7 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 6/308 47/18722 0.000114936363705956 0.00203426721503644 JUN/KLF2/CEBPB/HSPA1A/ATF3/EGR1 6 GO:0097028 dendritic cell differentiation 6/308 47/18722 0.000114936363705956 0.00203426721503644 HLA-B/CEBPB/IRF8/TMEM176B/TMEM176A/HMGB1 6 GO:0051098 regulation of binding 17/308 363/18722 0.000115705395249248 0.0020384411338151 B2M/NFKBIA/JUN/KLF4/IFIT1/TMSB4X/PHLDA2/HMGB2/IFIT2/SRI/HSP90AB1/C4orf3/APOE/EIF3E/HMGB1/CALM1/HES1 17 GO:0009636 response to toxic substance 14/308 262/18722 0.000118864355515408 0.00208448821621745 FOS/CCL3/CCL4/NUPR1/SRSF9/SOD2/PRDX3/GLRX/HBA2/APOE/UBA52/HBA1/S100A9/PRDX1 14 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 7/308 68/18722 0.000125107464535133 0.00218395359323202 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/HMGB1/ANXA1 7 GO:0038061 NIK/NF-kappaB signaling 10/308 143/18722 0.000130377556388459 0.00226560635487763 NFKBIA/TMSB4X/IL1B/NMI/PPP4C/EIF2AK2/EGFR/HMGB1/LAPTM5/PRDX1 10 GO:0051090 regulation of DNA-binding transcription factor activity 19/308 440/18722 0.000134517160957054 0.00232696428207609 NFKBIA/KLF4/TMSB4X/HSPA1A/NUPR1/TNFAIP3/IL1B/TRIM22/EIF2AK2/PRDX3/SRI/TRIB1/HSPA1B/S100A8/NPM1/TAX1BP1/SGK1/HES1/S100A9 19 GO:0002287 alpha-beta T cell activation involved in immune response 7/308 69/18722 0.000137296805272185 0.00234323967212306 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/HMGB1/ANXA1 7 GO:0002293 alpha-beta T cell differentiation involved in immune response 7/308 69/18722 0.000137296805272185 0.00234323967212306 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/HMGB1/ANXA1 7 GO:0034605 cellular response to heat 7/308 69/18722 0.000137296805272185 0.00234323967212306 HSPA1A/IER5/HSP90AB1/HSPA1B/DNAJB6/HSP90AA1/CXCL10 7 GO:0001890 placenta development 10/308 144/18722 0.000138104169672346 0.00234654329181057 JUNB/CEBPB/PHLDA2/PRDX3/GRB2/HSP90AB1/SOCS3/KRT8/DNAJB6/HES1 10 GO:0051101 regulation of DNA binding 9/308 118/18722 0.000146310265079849 0.00247497408584187 NFKBIA/JUN/KLF4/TMSB4X/HMGB2/SRI/HMGB1/CALM1/HES1 9 GO:0045185 maintenance of protein location 8/308 93/18722 0.000148533019483064 0.00250150543384913 NFKBIA/FBN2/TMSB4X/SRGN/HK2/SRI/HNRNPU/FBN1 8 GO:0002548 monocyte chemotaxis 7/308 70/18722 0.00015043160541348 0.00252236854164795 CCL3/CCL3L3/DUSP1/CCL4/HMGB1/ANXA1/CXCL10 7 GO:0033673 negative regulation of kinase activity 13/308 237/18722 0.000160030862438414 0.00266058863154409 GADD45B/SNCA/DUSP1/TNFAIP3/IL1B/PRDX3/TRIB1/NPM1/APOE/MLLT1/DNAJA1/HNRNPU/PKIB 13 GO:1990830 cellular response to leukemia inhibitory factor 8/308 94/18722 0.000160066802316281 0.00266058863154409 KLF4/NCL/HK2/CACYBP/SRSF3/SOCS3/EIF4A2/HNRNPU 8 GO:0042744 hydrogen peroxide catabolic process 5/308 32/18722 0.000163131351856283 0.00267792824484898 SNCA/PRDX3/HBA2/HBA1/PRDX1 5 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 5/308 32/18722 0.000163131351856283 0.00267792824484898 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/ANXA1 5 GO:0019083 viral transcription 6/308 50/18722 0.000163211425856608 0.00267792824484898 JUN/CCL3/CCL4/ZFP36/IFITM3/LARP7 6 GO:0030098 lymphocyte differentiation 17/308 374/18722 0.000165306049994234 0.00270070525268358 B2M/HLA-DRB1/KLF6/IRF8/HLA-DRA/CD83/NFKBIZ/IL1B/GPR183/EGR1/PTGER4/TNFSF13B/MAFB/RSAD2/HMGB1/LGALS1/ANXA1 17 GO:0002761 regulation of myeloid leukocyte differentiation 9/308 120/18722 0.000166292461672829 0.0027052599190435 JUN/FOS/CCL3/HLA-DRB1/CEBPB/TRIB1/MAFB/C1QC/FBN1 9 GO:1990823 response to leukemia inhibitory factor 8/308 95/18722 0.000172327896199249 0.00279156587783784 KLF4/NCL/HK2/CACYBP/SRSF3/SOCS3/EIF4A2/HNRNPU 8 GO:0051403 stress-activated MAPK cascade 13/308 239/18722 0.000173864192899653 0.0028045688162674 GADD45B/DUSP1/ZFP36/NCF1/IL1B/EIF2AK2/PTGER4/EGFR/TRIB1/SDCBP/HMGB1/DNAJA1/PRDX1 13 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 6/308 51/18722 0.000182444341144812 0.00293060805124629 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/ANXA1 6 GO:0045648 positive regulation of erythrocyte differentiation 5/308 33/18722 0.000189693494242573 0.00300912128003883 ISG15/HSPA1A/HMGB2/STAT1/HSPA1B 5 GO:1901099 negative regulation of signal transduction in absence of ligand 5/308 33/18722 0.000189693494242573 0.00300912128003883 HSPA1A/IFI6/IL1B/MCL1/HSPA1B 5 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 5/308 33/18722 0.000189693494242573 0.00300912128003883 HSPA1A/IFI6/IL1B/MCL1/HSPA1B 5 GO:0001959 regulation of cytokine-mediated signaling pathway 10/308 150/18722 0.000193046739226979 0.00303710981096602 ISG15/HSPA1A/CASP1/TNFAIP3/OAS1/CXCR4/HSP90AB1/OAS3/HSPA1B/LAPTM5 10 GO:0070665 positive regulation of leukocyte proliferation 10/308 150/18722 0.000193046739226979 0.00303710981096602 HLA-A/HLA-DPB1/IL1B/GPR183/HLA-DPA1/BST2/TNFSF13B/HMGB1/HES1/ANXA1 10 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 8/308 98/18722 0.000213828709690867 0.00335027523421387 HSPA1A/VDAC2/SOD2/TXNDC12/BID/HERPUD1/MCL1/DNAJA1 8 GO:0051973 positive regulation of telomerase activity 5/308 34/18722 0.000219429335807448 0.00342399326853827 KLF4/PTGES3/HSP90AB1/PKIB/HSP90AA1 5 GO:0070663 regulation of leukocyte proliferation 13/308 245/18722 0.000221702438445435 0.00344432552467304 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/TNFAIP3/IL1B/GPR183/HLA-DPA1/BST2/TNFSF13B/HMGB1/HES1/ANXA1 13 GO:0051651 maintenance of location in cell 12/308 213/18722 0.000222534241327293 0.00344432552467304 CCL3/SNCA/TMSB4X/SRGN/HK2/SRI/S100A8/APOE/HNRNPU/CALM1/S100A9/CXCL10 12 GO:0043620 regulation of DNA-templated transcription in response to stress 6/308 53/18722 0.000226257752210784 0.00348783623670091 JUN/KLF2/CEBPB/HSPA1A/ATF3/EGR1 6 GO:0000028 ribosomal small subunit assembly 4/308 19/18722 0.000229052926998077 0.0035167443370026 RPS28/RPS27/RPS27L/RPS15 4 GO:0002292 T cell differentiation involved in immune response 7/308 75/18722 0.000232247576941634 0.00355152994659147 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/HMGB1/ANXA1 7 GO:0031098 stress-activated protein kinase signaling cascade 13/308 247/18722 0.000239972021201584 0.00365503202013408 GADD45B/DUSP1/ZFP36/NCF1/IL1B/EIF2AK2/PTGER4/EGFR/TRIB1/SDCBP/HMGB1/DNAJA1/PRDX1 13 GO:1903364 positive regulation of cellular protein catabolic process 10/308 155/18722 0.000251894338253114 0.00381670712182997 HSPA1A/NUPR1/TNFAIP3/TRIB1/HERPUD1/SUMO2/HSPA1B/APOE/HSP90AA1/LAPTM5 10 GO:0060236 regulation of mitotic spindle organization 5/308 35/18722 0.000252583547429501 0.00381670712182997 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:0042102 positive regulation of T cell proliferation 8/308 101/18722 0.000263194668790497 0.00394585575994537 HLA-A/HLA-DPB1/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 8 GO:0098869 cellular oxidant detoxification 8/308 101/18722 0.000263194668790497 0.00394585575994537 SOD2/PRDX3/GLRX/HBA2/APOE/HBA1/S100A9/PRDX1 8 GO:0048025 negative regulation of mRNA splicing, via spliceosome 4/308 20/18722 0.000282624883178807 0.00418788731935109 SRSF4/SRSF9/SAP18/NPM1 4 GO:0072567 chemokine (C-X-C motif) ligand 2 production 4/308 20/18722 0.000282624883178807 0.00418788731935109 KLF4/OAS1/OAS3/HMGB1 4 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 4/308 20/18722 0.000282624883178807 0.00418788731935109 KLF4/OAS1/OAS3/HMGB1 4 GO:0009895 negative regulation of catabolic process 15/308 320/18722 0.000286930938027527 0.00421898836953553 SNCA/ZFP36/GABARAPL2/NUPR1/IL1B/DDIT4/HSP90AB1/CIRBP/EGFR/SDCBP/MCL1/SNX3/TIMP3/HNRNPU/APOC1 15 GO:0071496 cellular response to external stimulus 15/308 320/18722 0.000286930938027527 0.00421898836953553 JUN/FOS/AOC1/GABARAPL2/CASP1/IL1B/COMT/ATF3/EIF2AK2/PTGER4/MAP1LC3B/EGFR/HNRNPA1/NR4A2/RAC1 15 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 6/308 56/18722 0.000307063372338517 0.00448054684141279 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 6 GO:0071385 cellular response to glucocorticoid stimulus 6/308 56/18722 0.000307063372338517 0.00448054684141279 ZFP36/DDIT4/EGFR/SERPINF1/HNRNPU/ANXA1 6 GO:0035966 response to topologically incorrect protein 10/308 159/18722 0.000309175535410948 0.00449421320104963 PPP1R15A/HSPA1A/ATF3/EIF2AK2/HSP90AB1/HERPUD1/HSPA1B/HSPH1/DNAJA1/HSP90AA1 10 GO:0006446 regulation of translational initiation 7/308 79/18722 0.000320748975087106 0.0046208797080505 PPP1R15A/EIF1B/PAIP2/EIF2AK2/EIF4A2/NPM1/EIF3E 7 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 7/308 79/18722 0.000320748975087106 0.0046208797080505 RPL39/CXCL8/CXCL2/CXCL3/DEFB1/S100A9/CXCL10 7 GO:0046634 regulation of alpha-beta T cell activation 8/308 104/18722 0.000321515564305894 0.0046208797080505 HLA-A/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/HSPH1/ANXA1 8 GO:0002369 T cell cytokine production 5/308 37/18722 0.000330165387914173 0.00470978461938762 B2M/HLA-A/IL1B/HLA-F/RSAD2 5 GO:0002724 regulation of T cell cytokine production 5/308 37/18722 0.000330165387914173 0.00470978461938762 B2M/HLA-A/IL1B/HLA-F/RSAD2 5 GO:0060760 positive regulation of response to cytokine stimulus 6/308 57/18722 0.000338505191881926 0.00481080055228478 HSPA1A/CASP1/IFIH1/CXCR4/HSPA1B/LAPTM5 6 GO:0046597 negative regulation of viral entry into host cell 4/308 21/18722 0.000344626232503704 0.00484377237816787 LY6E/IFITM3/SNX3/IFITM1 4 GO:0071605 monocyte chemotactic protein-1 production 4/308 21/18722 0.000344626232503704 0.00484377237816787 IL1B/OAS1/OAS3/HMGB1 4 GO:0071637 regulation of monocyte chemotactic protein-1 production 4/308 21/18722 0.000344626232503704 0.00484377237816787 IL1B/OAS1/OAS3/HMGB1 4 GO:0030217 T cell differentiation 13/308 257/18722 0.000351907267749026 0.00492799078609716 B2M/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/IL1B/GPR183/EGR1/PTGER4/MAFB/RSAD2/HMGB1/ANXA1 13 GO:2000278 regulation of DNA biosynthetic process 8/308 106/18722 0.000365951038014766 0.00510320108596938 KLF4/DUSP1/PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 8 GO:0034284 response to monosaccharide 12/308 225/18722 0.00036708875193345 0.00510320108596938 HLA-DRB1/MPC2/ENSA/VAMP2/SOD2/EGR1/SRI/LDHA/SERPINF1/RAC1/LGALS1/TXNIP 12 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/308 58/18722 0.00037241261789494 0.00515845448627666 NUPR1/BID/MCL1/S100A8/UBB/S100A9 6 GO:0071241 cellular response to inorganic substance 12/308 226/18722 0.00038208598943212 0.00527333840288445 JUND/B2M/JUN/FOSB/FOS/SNCA/AOC1/JUNB/NCF1/CACYBP/EGFR/SERPINF1 12 GO:0090224 regulation of spindle organization 5/308 39/18722 0.000424551030577567 0.00581741430070981 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 5/308 39/18722 0.000424551030577567 0.00581741430070981 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/ANXA1 5 GO:0031397 negative regulation of protein ubiquitination 7/308 83/18722 0.000434461522578921 0.0059319514314972 ISG15/HSPA1A/TNFAIP3/HSPA1B/DNAJA1/RPL37/RPS15 7 GO:0050671 positive regulation of lymphocyte proliferation 9/308 137/18722 0.000446962915854522 0.00605410574561623 HLA-A/HLA-DPB1/IL1B/GPR183/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 9 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 6/308 60/18722 0.00044815901805111 0.00605410574561623 NFKBIA/HSPA1A/TNFAIP3/IFIH1/OAS3/HSPA1B 6 GO:0051851 modulation by host of symbiont process 6/308 60/18722 0.00044815901805111 0.00605410574561623 JUN/CCL3/CCL4/SAP30/IFI27/APOE 6 GO:0045732 positive regulation of protein catabolic process 12/308 231/18722 0.000465082558916333 0.00626060078428571 HSPA1A/NUPR1/TNFAIP3/IL1B/TRIB1/HERPUD1/SUMO2/HSPA1B/APOE/OAZ1/HSP90AA1/LAPTM5 12 GO:0032946 positive regulation of mononuclear cell proliferation 9/308 138/18722 0.000471379641115427 0.00632310304555887 HLA-A/HLA-DPB1/IL1B/GPR183/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 9 GO:0042098 T cell proliferation 11/308 199/18722 0.000474413262715261 0.00634154511664491 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/PSMB10/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 11 GO:0045429 positive regulation of nitric oxide biosynthetic process 5/308 40/18722 0.0004787367572962 0.00637704049875739 KLF2/KLF4/IL1B/HSP90AB1/HSP90AA1 5 GO:0071384 cellular response to corticosteroid stimulus 6/308 61/18722 0.000490274171076583 0.00650804915286728 ZFP36/DDIT4/EGFR/SERPINF1/HNRNPU/ANXA1 6 GO:0042026 protein refolding 4/308 23/18722 0.000496840496076359 0.00654972833275835 B2M/HSPA1A/HSPA1B/HSP90AA1 4 GO:0051131 chaperone-mediated protein complex assembly 4/308 23/18722 0.000496840496076359 0.00654972833275835 HSPA1A/PTGES3/HSP90AB1/HSP90AA1 4 GO:0045428 regulation of nitric oxide biosynthetic process 6/308 62/18722 0.000535407181248747 0.00703388884506515 KLF2/KLF4/IL1B/HSP90AB1/RAC1/HSP90AA1 6 GO:1904407 positive regulation of nitric oxide metabolic process 5/308 41/18722 0.000537966644136874 0.00704330986484682 KLF2/KLF4/IL1B/HSP90AB1/HSP90AA1 5 GO:0042129 regulation of T cell proliferation 10/308 171/18722 0.000549949334645102 0.00716864109798437 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 10 GO:0050921 positive regulation of chemotaxis 9/308 141/18722 0.000551289689460477 0.00716864109798437 CCL3/TMSB4X/CCL4/CXCL8/SWAP70/CXCR4/RAC1/HMGB1/CXCL10 9 GO:0002708 positive regulation of lymphocyte mediated immunity 8/308 113/18722 0.000562498937211487 0.0072896048710492 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2 8 GO:0002221 pattern recognition receptor signaling pathway 10/308 172/18722 0.000575578225682496 0.00743390390805467 NFKBIA/HSPA1A/TNFAIP3/NMI/OAS1/IFIH1/RSAD2/OAS3/HSPA1B/HMGB1 10 GO:0031343 positive regulation of cell killing 6/308 63/18722 0.000583704704467488 0.00750643124968868 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 6 GO:1901361 organic cyclic compound catabolic process 19/308 495/18722 0.000585120719960038 0.00750643124968868 YWHAH/HSPA1A/ZFP36/OAS2/COMT/BLVRA/RNASET2/SSB/HNRNPM/TYMP/CIRBP/HSPA1B/DNASE2/NPM1/APOE/EIF3E/HNRNPU/DDX5/APOBEC3A 19 GO:0002726 positive regulation of T cell cytokine production 4/308 24/18722 0.000588538574303013 0.00752502665404822 B2M/HLA-A/IL1B/RSAD2 4 GO:0002286 T cell activation involved in immune response 8/308 114/18722 0.000596475207489592 0.00760108239410903 HLA-DRB1/HLA-DRA/NFKBIZ/GPR183/PTGER4/APBB1IP/HMGB1/ANXA1 8 GO:0002440 production of molecular mediator of immune response 14/308 308/18722 0.000616032585092155 0.00782422781663557 B2M/HLA-A/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/IL1B/HLA-F/HLA-DPA1/BST2/RSAD2/LAPTM5 14 GO:0080164 regulation of nitric oxide metabolic process 6/308 64/18722 0.00063531671283986 0.00804243640128074 KLF2/KLF4/IL1B/HSP90AB1/RAC1/HSP90AA1 6 GO:0090084 negative regulation of inclusion body assembly 3/308 11/18722 0.000659639789790214 0.00832278190220459 HSPA1A/HSPA1B/DNAJB6 3 GO:0007006 mitochondrial membrane organization 8/308 116/18722 0.000669402995151872 0.00837751161892256 SNCA/HSPA1A/BNIP3L/HK2/VDAC2/BID/HSP90AA1/CALM1 8 GO:1990748 cellular detoxification 8/308 116/18722 0.000669402995151872 0.00837751161892256 SOD2/PRDX3/GLRX/HBA2/APOE/HBA1/S100A9/PRDX1 8 GO:0034142 toll-like receptor 4 signaling pathway 5/308 43/18722 0.000672742889617898 0.00837751161892256 NFKBIA/TNFAIP3/NMI/OAS1/HMGB1 5 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 5/308 43/18722 0.000672742889617898 0.00837751161892256 HSPA1A/IFI6/IL1B/MCL1/HSPA1B 5 GO:0002573 myeloid leukocyte differentiation 11/308 208/18722 0.000686176163158237 0.00844763950718576 JUN/FOS/CCL3/HLA-DRB1/JUNB/CEBPB/GPR183/TRIB1/MAFB/C1QC/FBN1 11 GO:0002720 positive regulation of cytokine production involved in immune response 6/308 65/18722 0.000690396427492844 0.00844763950718576 B2M/HLA-A/IL1B/HLA-F/RSAD2/LAPTM5 6 GO:0038034 signal transduction in absence of ligand 6/308 65/18722 0.000690396427492844 0.00844763950718576 HSPA1A/IFI6/IL1B/BCL2A1/MCL1/HSPA1B 6 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 6/308 65/18722 0.000690396427492844 0.00844763950718576 HSPA1A/IFI6/IL1B/BCL2A1/MCL1/HSPA1B 6 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 4/308 25/18722 0.000691632530930982 0.00844763950718576 NFKBIA/HSPA1A/TNFAIP3/HSPA1B 4 GO:1901798 positive regulation of signal transduction by p53 class mediator 4/308 25/18722 0.000691632530930982 0.00844763950718576 DDX5/RPL37/RPS15/UBB 4 GO:0048608 reproductive structure development 17/308 424/18722 0.000698557157016143 0.00850504462188762 JUNB/CEBPB/PHLDA2/HMGB2/NUPR1/PRDX3/GRB2/BASP1/HSP90AB1/SOCS3/SERPINF1/KRT8/DNAJB6/TNFSF10/UBB/HES1/ANXA1 17 GO:0045638 negative regulation of myeloid cell differentiation 7/308 90/18722 0.000709117076697151 0.00860620502924828 NFKBIA/CCL3/ZFP36/TRIB1/MAFB/C1QC/FBN1 7 GO:0002685 regulation of leukocyte migration 11/308 210/18722 0.000742598901214269 0.00898403670677895 CCL3/DUSP1/CCL4/CXCL8/SWAP70/PTGER4/RAC1/HMGB1/CD9/ANXA1/CXCL10 11 GO:0060711 labyrinthine layer development 5/308 44/18722 0.000748895677692719 0.00899503235028404 JUNB/GRB2/SOCS3/DNAJB6/HES1 5 GO:2000573 positive regulation of DNA biosynthetic process 6/308 66/18722 0.000749100247828026 0.00899503235028404 KLF4/PTGES3/HSP90AB1/HNRNPA1/PKIB/HSP90AA1 6 GO:0031331 positive regulation of cellular catabolic process 17/308 427/18722 0.000755272138226832 0.00899503235028404 SNCA/HSPA1A/BNIP3L/ZFP36/NUPR1/TNFAIP3/IL1B/TRIM22/BID/TRIB1/HERPUD1/SUMO2/HSPA1B/APOE/HMGB1/HSP90AA1/LAPTM5 17 GO:0043254 regulation of protein-containing complex assembly 17/308 427/18722 0.000755272138226832 0.00899503235028404 SNCA/ISG15/TMSB4X/HSPA1A/VDAC2/EIF2AK2/GRB2/PTGER4/BID/HSPA1B/RAC1/MYADM/APOE/HMGB1/ARPC3/HSP90AA1/IQGAP2 17 GO:0061458 reproductive system development 17/308 427/18722 0.000755272138226832 0.00899503235028404 JUNB/CEBPB/PHLDA2/HMGB2/NUPR1/PRDX3/GRB2/BASP1/HSP90AB1/SOCS3/SERPINF1/KRT8/DNAJB6/TNFSF10/UBB/HES1/ANXA1 17 GO:0006469 negative regulation of protein kinase activity 11/308 212/18722 0.000802824792496056 0.00943069814766478 GADD45B/SNCA/DUSP1/TNFAIP3/IL1B/TRIB1/NPM1/APOE/MLLT1/DNAJA1/PKIB 11 GO:0009749 response to glucose 11/308 212/18722 0.000802824792496056 0.00943069814766478 HLA-DRB1/MPC2/ENSA/VAMP2/EGR1/SRI/LDHA/SERPINF1/RAC1/LGALS1/TXNIP 11 GO:0043523 regulation of neuron apoptotic process 11/308 212/18722 0.000802824792496056 0.00943069814766478 JUN/CCL3/SNCA/CEBPB/NUPR1/SOD2/HSP90AB1/MCL1/NR4A2/SET/APOE 11 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 4/308 26/18722 0.000806879942052981 0.00943069814766478 NFKBIA/HSPA1A/TNFAIP3/HSPA1B 4 GO:1903312 negative regulation of mRNA metabolic process 7/308 92/18722 0.00080863391164899 0.00943069814766478 ZFP36/SRSF4/SRSF9/CIRBP/SAP18/NPM1/HNRNPU 7 GO:0051402 neuron apoptotic process 12/308 246/18722 0.000810534086737145 0.00943069814766478 JUN/CCL3/SNCA/CEBPB/NUPR1/SOD2/HSP90AB1/BID/MCL1/NR4A2/SET/APOE 12 GO:0035914 skeletal muscle cell differentiation 6/308 67/18722 0.000811587677369007 0.00943069814766478 FOS/SAP30/NUPR1/ATF3/EGR1/DDX5 6 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 6/308 67/18722 0.000811587677369007 0.00943069814766478 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/ANXA1 6 GO:0043409 negative regulation of MAPK cascade 10/308 180/18722 0.000818389725389345 0.00947100327221788 FBLN1/KLF4/DUSP1/DUSP2/IL1B/ATF3/GBP1/APOE/TIMP3/DNAJA1 10 GO:0051592 response to calcium ion 9/308 149/18722 0.000820011007874475 0.00947100327221788 JUND/FOSB/FOS/DUSP1/JUNB/CACYBP/EGFR/CALM1/TXNIP 9 GO:0051051 negative regulation of transport 18/308 470/18722 0.000832752094941927 0.00958919053904514 SNCA/PLSCR1/IL1B/HLA-F/COMT/SRI/C4orf3/BST2/RSAD2/SDCBP/SNX3/RAC1/APOE/OAZ1/HMGB1/CALM1/ANXA1/APOC1 18 GO:0070661 leukocyte proliferation 14/308 318/18722 0.00084066349039348 0.00965122079211493 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/TNFAIP3/IL1B/GPR183/PSMB10/HLA-DPA1/BST2/TNFSF13B/HMGB1/HES1/ANXA1 14 GO:0002424 T cell mediated immune response to tumor cell 3/308 12/18722 0.000868839795288699 0.00994483394427753 HLA-A/HLA-DRB1/HMGB1 3 GO:0046637 regulation of alpha-beta T cell differentiation 6/308 68/18722 0.00087802124635293 0.00999010483573587 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/ANXA1 6 GO:0046686 response to cadmium ion 6/308 68/18722 0.00087802124635293 0.00999010483573587 B2M/JUN/FOS/NCF1/SOD2/EGFR 6 GO:0002690 positive regulation of leukocyte chemotaxis 7/308 94/18722 0.000918869649000432 0.0103318784356725 CCL3/CCL4/CXCL8/SWAP70/RAC1/HMGB1/CXCL10 7 GO:0019080 viral gene expression 7/308 94/18722 0.000918869649000432 0.0103318784356725 JUN/CCL3/CCL4/ZFP36/IFITM3/SSB/LARP7 7 GO:0030316 osteoclast differentiation 7/308 94/18722 0.000918869649000432 0.0103318784356725 FOS/CCL3/JUNB/CEBPB/GPR183/MAFB/FBN1 7 GO:0051702 biological process involved in interaction with symbiont 7/308 94/18722 0.000918869649000432 0.0103318784356725 JUN/CCL3/CCL4/SAP30/IFI27/APOE/FN1 7 GO:0002688 regulation of leukocyte chemotaxis 8/308 122/18722 0.000932298504344577 0.010421570707922 CCL3/DUSP1/CCL4/CXCL8/SWAP70/RAC1/HMGB1/CXCL10 8 GO:0019730 antimicrobial humoral response 8/308 122/18722 0.000932298504344577 0.010421570707922 RPL39/HLA-A/CXCL8/CXCL2/CXCL3/DEFB1/S100A9/CXCL10 8 GO:0032703 negative regulation of interleukin-2 production 4/308 27/18722 0.000935041255375642 0.0104217571991285 ZFP36/TNFAIP3/GBP1/LAPTM5 4 GO:0051092 positive regulation of NF-kappaB transcription factor activity 9/308 152/18722 0.000944835765341831 0.010480836608513 HSPA1A/IL1B/TRIM22/EIF2AK2/PRDX3/HSPA1B/S100A8/NPM1/S100A9 9 GO:0007004 telomere maintenance via telomerase 6/308 69/18722 0.000948566431217763 0.010480836608513 PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 6 GO:1901224 positive regulation of NIK/NF-kappaB signaling 6/308 69/18722 0.000948566431217763 0.010480836608513 IL1B/NMI/EIF2AK2/EGFR/HMGB1/LAPTM5 6 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 7/308 95/18722 0.000978253652064163 0.0107777052214447 ISG15/HSPA1A/TNFAIP3/HSPA1B/DNAJA1/RPL37/RPS15 7 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 5/308 47/18722 0.00101616155967766 0.011127346801182 HSPA1A/CASP1/TNFAIP3/HSPA1B/LAPTM5 5 GO:0051972 regulation of telomerase activity 5/308 47/18722 0.00101616155967766 0.011127346801182 KLF4/PTGES3/HSP90AB1/PKIB/HSP90AA1 5 GO:1903311 regulation of mRNA metabolic process 13/308 288/18722 0.00101872126089816 0.011127346801182 NCL/ZFP36/SRSF4/SRSF9/HNRNPM/SRSF3/CIRBP/LARP7/HNRNPA1/SAP18/NPM1/HNRNPU/DDX5 13 GO:0009743 response to carbohydrate 12/308 253/18722 0.00103345255447307 0.0112233296045926 HLA-DRB1/MPC2/ENSA/VAMP2/SOD2/EGR1/SRI/LDHA/SERPINF1/RAC1/LGALS1/TXNIP 12 GO:0001909 leukocyte mediated cytotoxicity 8/308 124/18722 0.00103631581229955 0.0112233296045926 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F/CTSH/PRDX1 8 GO:0097237 cellular response to toxic substance 8/308 124/18722 0.00103631581229955 0.0112233296045926 SOD2/PRDX3/GLRX/HBA2/APOE/HBA1/S100A9/PRDX1 8 GO:0002718 regulation of cytokine production involved in immune response 7/308 96/18722 0.00104061677229851 0.0112380732217435 B2M/HLA-A/IL1B/HLA-F/BST2/RSAD2/LAPTM5 7 GO:0009746 response to hexose 11/308 219/18722 0.00104644598763398 0.0112691915795063 HLA-DRB1/MPC2/ENSA/VAMP2/EGR1/SRI/LDHA/SERPINF1/RAC1/LGALS1/TXNIP 11 GO:0031342 negative regulation of cell killing 4/308 28/18722 0.00107687819319226 0.0114997355658492 HLA-B/HLA-A/HLA-F/HSP90AB1 4 GO:0032607 interferon-alpha production 4/308 28/18722 0.00107687819319226 0.0114997355658492 NMI/IFIH1/STAT1/HMGB1 4 GO:0032647 regulation of interferon-alpha production 4/308 28/18722 0.00107687819319226 0.0114997355658492 NMI/IFIH1/STAT1/HMGB1 4 GO:0022618 ribonucleoprotein complex assembly 11/308 220/18722 0.00108576659862338 0.0115623557285158 SRSF5/RPS28/SRSF9/PTGES3/HSP90AB1/RPS27/RPL3/EIF3E/RPS27L/HSP90AA1/RPS15 11 GO:0070585 protein localization to mitochondrion 8/308 125/18722 0.00109169466852143 0.0115931908826595 ISG15/BNIP3L/HK2/RALA/BID/DNAJA1/HSP90AA1/CALM1 8 GO:0032722 positive regulation of chemokine production 6/308 71/18722 0.00110266778175252 0.0116772823535731 IL1B/OAS1/EIF2AK2/EGR1/OAS3/HMGB1 6 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 7/308 97/18722 0.0011060624462765 0.0116808749505941 HSPA1A/HMGB2/IFI6/TNFAIP3/IL1B/MCL1/HSPA1B 7 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 3/308 13/18722 0.00111578748750888 0.0116867275746478 HSPA1A/TNFAIP3/HSPA1B 3 GO:0070486 leukocyte aggregation 3/308 13/18722 0.00111578748750888 0.0116867275746478 IL1B/S100A8/S100A9 3 GO:1902947 regulation of tau-protein kinase activity 3/308 13/18722 0.00111578748750888 0.0116867275746478 EGR1/HSP90AB1/HSP90AA1 3 GO:1905710 positive regulation of membrane permeability 5/308 48/18722 0.00111925492103248 0.0116910151997464 HSPA1A/BNIP3L/VDAC2/BID/LAPTM5 5 GO:0034976 response to endoplasmic reticulum stress 12/308 256/18722 0.00114348743708575 0.0119115871171085 JUN/PPP1R15A/CEBPB/HSPA1A/CXCL8/NUPR1/ATF3/EIF2AK2/TXNDC12/BID/NRBF2/HERPUD1 12 GO:0002367 cytokine production involved in immune response 7/308 98/18722 0.00117469581062924 0.0121495731662439 B2M/HLA-A/IL1B/HLA-F/BST2/RSAD2/LAPTM5 7 GO:0032642 regulation of chemokine production 7/308 98/18722 0.00117469581062924 0.0121495731662439 KLF4/IL1B/OAS1/EIF2AK2/EGR1/OAS3/HMGB1 7 GO:0001701 in utero embryonic development 15/308 367/18722 0.0011758676619174 0.0121495731662439 KLF2/KLF4/JUNB/CEBPB/PHLDA2/UBE2B/SF3B6/LY6E/SBDS/SYF2/GRB2/SOCS3/KRT8/DNAJB6/HES1 15 GO:0032729 positive regulation of interferon-gamma production 6/308 72/18722 0.00118656886625818 0.0121644277843504 HLA-A/ISG15/IRF8/HLA-DPB1/IL1B/HLA-DPA1 6 GO:1902107 positive regulation of leukocyte differentiation 9/308 157/18722 0.00118685104984637 0.0121644277843504 JUN/FOS/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/TRIB1/HMGB1/ANXA1 9 GO:1903708 positive regulation of hemopoiesis 9/308 157/18722 0.00118685104984637 0.0121644277843504 JUN/FOS/HLA-DRB1/HLA-DRA/CD83/NFKBIZ/TRIB1/HMGB1/ANXA1 9 GO:0050920 regulation of chemotaxis 11/308 223/18722 0.00121110891418824 0.0123798646495766 CCL3/DUSP1/TMSB4X/CCL4/CXCL8/SWAP70/GPR183/CXCR4/RAC1/HMGB1/CXCL10 11 GO:0002762 negative regulation of myeloid leukocyte differentiation 5/308 49/18722 0.00122989556722697 0.012538140998733 CCL3/TRIB1/MAFB/C1QC/FBN1 5 GO:0050686 negative regulation of mRNA processing 4/308 29/18722 0.0012331522405241 0.012538140998733 SRSF4/SRSF9/SAP18/NPM1 4 GO:0031341 regulation of cell killing 7/308 99/18722 0.00124662367324775 0.012608048420175 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F/HSP90AB1 7 GO:0032602 chemokine production 7/308 99/18722 0.00124662367324775 0.012608048420175 KLF4/IL1B/OAS1/EIF2AK2/EGR1/OAS3/HMGB1 7 GO:0050670 regulation of lymphocyte proliferation 11/308 225/18722 0.00130110862403061 0.0131243753817125 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/GPR183/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 11 GO:0032872 regulation of stress-activated MAPK cascade 10/308 192/18722 0.00133548594152806 0.0134356914591099 GADD45B/DUSP1/NCF1/IL1B/EIF2AK2/EGFR/SDCBP/HMGB1/DNAJA1/PRDX1 10 GO:0001961 positive regulation of cytokine-mediated signaling pathway 5/308 50/18722 0.00134841602737923 0.0134947499284576 HSPA1A/CASP1/CXCR4/HSPA1B/LAPTM5 5 GO:0046638 positive regulation of alpha-beta T cell differentiation 5/308 50/18722 0.00134841602737923 0.0134947499284576 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/ANXA1 5 GO:0051881 regulation of mitochondrial membrane potential 6/308 74/18722 0.00136895375661292 0.0136645175235802 BNIP3L/CASP1/IFI6/PRDX3/BID/UBB 6 GO:0009896 positive regulation of catabolic process 18/308 492/18722 0.001393066808443 0.0137871431160275 SNCA/HSPA1A/BNIP3L/ZFP36/NUPR1/TNFAIP3/IL1B/TRIM22/BID/TRIB1/HERPUD1/SUMO2/HSPA1B/APOE/OAZ1/HMGB1/HSP90AA1/LAPTM5 18 GO:0032944 regulation of mononuclear cell proliferation 11/308 227/18722 0.00139653501455866 0.0137871431160275 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/GPR183/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 11 GO:0071826 ribonucleoprotein complex subunit organization 11/308 227/18722 0.00139653501455866 0.0137871431160275 SRSF5/RPS28/SRSF9/PTGES3/HSP90AB1/RPS27/RPL3/EIF3E/RPS27L/HSP90AA1/RPS15 11 GO:0006576 cellular biogenic amine metabolic process 7/308 101/18722 0.00140079829912501 0.0137871431160275 SNCA/AOC1/LY6E/COMT/SMS/NR4A2/OAZ1 7 GO:0043558 regulation of translational initiation in response to stress 3/308 14/18722 0.00140287697413934 0.0137871431160275 PPP1R15A/EIF2AK2/NPM1 3 GO:0043922 negative regulation by host of viral transcription 3/308 14/18722 0.00140287697413934 0.0137871431160275 JUN/CCL3/CCL4 3 GO:0050777 negative regulation of immune response 10/308 194/18722 0.00144312030019252 0.0141462792503487 HLA-B/HLA-A/HLA-DRB1/ISG15/TNFAIP3/NMI/HLA-F/OAS1/OAS3/ANXA1 10 GO:0043434 response to peptide hormone 16/308 414/18722 0.00145718494186072 0.014247616452004 JUND/SRSF5/SRSF4/IL1B/VAMP2/CACYBP/EGR1/GRB2/RAB8A/STAT1/SOCS3/NR4A2/BTG1/TNFSF10/FBN1/ANXA1 16 GO:0006278 RNA-dependent DNA biosynthetic process 6/308 75/18722 0.00146779777223651 0.014278348303461 PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 6 GO:0048662 negative regulation of smooth muscle cell proliferation 6/308 75/18722 0.00146779777223651 0.014278348303461 KLF4/TNFAIP3/SOD2/COMT/TRIB1/APOE 6 GO:0032677 regulation of interleukin-8 production 7/308 102/18722 0.00148326675695225 0.0143922051061636 KLF4/TMSB4X/HSPA1A/IL1B/HSPA1B/HMGB1/ANXA1 7 GO:0045444 fat cell differentiation 11/308 229/18722 0.00149763207158234 0.0144764608465835 KLF4/CEBPB/ZFP36/MAFB/PSMB8/ARL4A/METRNL/NR4A2/HNRNPU/ADIRF/HES1 11 GO:0070302 regulation of stress-activated protein kinase signaling cascade 10/308 195/18722 0.00149952354047792 0.0144764608465835 GADD45B/DUSP1/NCF1/IL1B/EIF2AK2/EGFR/SDCBP/HMGB1/DNAJA1/PRDX1 10 GO:0030522 intracellular receptor signaling pathway 12/308 265/18722 0.00153345346119526 0.0147667319449609 NFKBIA/KLF2/YWHAH/HSPA1A/TNFAIP3/IFIH1/PTGES3/OAS3/NR4A2/HSPA1B/DNAJA1/DDX5 12 GO:0072331 signal transduction by p53 class mediator 9/308 163/18722 0.00154093282920664 0.0147837233212394 NUPR1/DDIT4/NPM1/SGK1/DDX5/RPL37/RPS27L/RPS15/UBB 9 GO:0002697 regulation of immune effector process 14/308 339/18722 0.00154295202855729 0.0147837233212394 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/NCF1/NFKBIZ/IL1B/HLA-F/BST2/RSAD2/HMGB1/LAPTM5/ANXA1 14 GO:0032637 interleukin-8 production 7/308 103/18722 0.00156947303562415 0.0149867976811295 KLF4/TMSB4X/HSPA1A/IL1B/HSPA1B/HMGB1/ANXA1 7 GO:0006809 nitric oxide biosynthetic process 6/308 76/18722 0.00157198688729608 0.0149867976811295 KLF2/KLF4/IL1B/HSP90AB1/RAC1/HSP90AA1 6 GO:0001516 prostaglandin biosynthetic process 4/308 31/18722 0.00159204791780952 0.0151027275180789 IL1B/PTGES3/CBR1/ANXA1 4 GO:0046457 prostanoid biosynthetic process 4/308 31/18722 0.00159204791780952 0.0151027275180789 IL1B/PTGES3/CBR1/ANXA1 4 GO:0007162 negative regulation of cell adhesion 13/308 303/18722 0.00160713450005216 0.0152081069150975 FBLN1/HLA-DRB1/KLF4/DUSP1/CEBPB/SWAP70/GBP1/MYADM/HMGB1/LAPTM5/CD9/LGALS1/ANXA1 13 GO:0032271 regulation of protein polymerization 11/308 232/18722 0.0016604597652322 0.015673920203661 SNCA/TMSB4X/HSPA1A/VDAC2/GRB2/HSPA1B/RAC1/MYADM/ARPC3/HSP90AA1/IQGAP2 11 GO:0045765 regulation of angiogenesis 14/308 342/18722 0.00167490274148779 0.0157713132529749 KLF2/KLF4/RHOB/CXCL8/TNFAIP3/IL1B/HK2/CXCR4/STAT1/SERPINF1/BTG1/HMGB1/CTSH/CXCL10 14 GO:0000380 alternative mRNA splicing, via spliceosome 6/308 77/18722 0.00168170692665476 0.0157964756280126 SRSF9/HNRNPM/HNRNPA1/SAP18/HNRNPU/DDX5 6 GO:0002705 positive regulation of leukocyte mediated immunity 8/308 134/18722 0.00170402968554624 0.0159669252153022 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2 8 GO:0032897 negative regulation of viral transcription 3/308 15/18722 0.0017323541564252 0.0161138441362859 ZFP36/IFITM3/LARP7 3 GO:0042994 cytoplasmic sequestering of transcription factor 3/308 15/18722 0.0017323541564252 0.0161138441362859 NFKBIA/TMSB4X/SRI 3 GO:0048569 post-embryonic animal organ development 3/308 15/18722 0.0017323541564252 0.0161138441362859 KLF4/LDHA/FBN1 3 GO:0097345 mitochondrial outer membrane permeabilization 4/308 32/18722 0.00179617885580284 0.0165553939206263 HSPA1A/BNIP3L/VDAC2/BID 4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/308 78/18722 0.00179714582188331 0.0165553939206263 KLF4/SNCA/IFI6/PRDX3/HERPUD1/DNAJB6 6 GO:0070373 negative regulation of ERK1 and ERK2 cascade 6/308 78/18722 0.00179714582188331 0.0165553939206263 FBLN1/KLF4/DUSP1/ATF3/GBP1/TIMP3 6 GO:0090559 regulation of membrane permeability 6/308 78/18722 0.00179714582188331 0.0165553939206263 HSPA1A/BNIP3L/HK2/VDAC2/BID/LAPTM5 6 GO:0007254 JNK cascade 9/308 167/18722 0.00182084911956224 0.0167334283271309 GADD45B/NCF1/IL1B/PTGER4/EGFR/TRIB1/SDCBP/HMGB1/DNAJA1 9 GO:0002699 positive regulation of immune effector process 11/308 235/18722 0.00183748382387016 0.0168458049368241 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/NFKBIZ/IL1B/HLA-F/RSAD2/LAPTM5/ANXA1 11 GO:0035821 modulation of process of other organism 7/308 106/18722 0.00185167298943508 0.016935277125862 JUN/CCL3/CCL4/SAP30/IFI27/APOE/S100A9 7 GO:0002706 regulation of lymphocyte mediated immunity 9/308 168/18722 0.00189682165344553 0.0173067999549457 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/RSAD2/HMGB1 9 GO:1901342 regulation of vasculature development 14/308 348/18722 0.00196710174482056 0.01790530945345 KLF2/KLF4/RHOB/CXCL8/TNFAIP3/IL1B/HK2/CXCR4/STAT1/SERPINF1/BTG1/HMGB1/CTSH/CXCL10 14 GO:0019439 aromatic compound catabolic process 17/308 467/18722 0.0019778362149968 0.0179602561756123 HSPA1A/ZFP36/OAS2/COMT/BLVRA/RNASET2/SSB/HNRNPM/TYMP/CIRBP/HSPA1B/DNASE2/NPM1/EIF3E/HNRNPU/DDX5/APOBEC3A 17 GO:0038066 p38MAPK cascade 5/308 55/18722 0.00207106285274056 0.0186951007141452 GADD45B/DUSP1/ZFP36/NCF1/IL1B 5 GO:0061614 pri-miRNA transcription by RNA polymerase II 5/308 55/18722 0.00207106285274056 0.0186951007141452 JUN/FOS/KLF4/EGR1/DDX5 5 GO:0042742 defense response to bacterium 14/308 350/18722 0.00207342995103258 0.0186951007141452 RPL39/HLA-A/ISG15/CEBPB/IRF8/HMGB2/GBP4/CASP1/OAS1/OAS2/OAS3/S100A8/DEFB1/S100A9 14 GO:0071383 cellular response to steroid hormone stimulus 10/308 204/18722 0.00209221886676073 0.018820124065003 YWHAH/ZFP36/DDIT4/PTGES3/EGFR/SERPINF1/DNAJA1/HNRNPU/DDX5/ANXA1 10 GO:0051238 sequestering of metal ion 3/308 16/18722 0.00210632188806973 0.0188582402297203 SRI/S100A8/S100A9 3 GO:0061684 chaperone-mediated autophagy 3/308 16/18722 0.00210632188806973 0.0188582402297203 SNCA/EEF1A1/HSP90AA1 3 GO:0010833 telomere maintenance via telomere lengthening 6/308 81/18722 0.00217968437871573 0.0193789148368145 PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 6 GO:0046209 nitric oxide metabolic process 6/308 81/18722 0.00217968437871573 0.0193789148368145 KLF2/KLF4/IL1B/HSP90AB1/RAC1/HSP90AA1 6 GO:0051817 modulation of process of other organism involved in symbiotic interaction 6/308 81/18722 0.00217968437871573 0.0193789148368145 JUN/CCL3/CCL4/SAP30/IFI27/APOE 6 GO:0046034 ATP metabolic process 12/308 277/18722 0.00221810779218083 0.0196747705092977 SNCA/TMSB4X/HSPA1A/NUPR1/HK2/DDIT4/SDHD/BID/LDHA/HSPA1B/ALDOA/UQCR11 12 GO:0043388 positive regulation of DNA binding 5/308 56/18722 0.00224400397827017 0.0198583963169603 KLF4/HMGB2/HMGB1/CALM1/HES1 5 GO:0051085 chaperone cofactor-dependent protein refolding 4/308 34/18722 0.00225754087131049 0.0199320525427714 HSPA1A/PTGES3/HSPA1B/HSPH1 4 GO:0006401 RNA catabolic process 12/308 278/18722 0.00228493430804784 0.0201274282480804 HSPA1A/ZFP36/OAS2/RNASET2/SSB/HNRNPM/CIRBP/HSPA1B/NPM1/EIF3E/HNRNPU/DDX5 12 GO:0051099 positive regulation of binding 9/308 173/18722 0.0023155726556902 0.0202952878261098 B2M/KLF4/HMGB2/HSP90AB1/APOE/EIF3E/HMGB1/CALM1/HES1 9 GO:0001910 regulation of leukocyte mediated cytotoxicity 6/308 82/18722 0.0023199165001334 0.0202952878261098 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F 6 GO:2001057 reactive nitrogen species metabolic process 6/308 82/18722 0.0023199165001334 0.0202952878261098 KLF2/KLF4/IL1B/HSP90AB1/RAC1/HSP90AA1 6 GO:0016064 immunoglobulin mediated immune response 10/308 207/18722 0.00232720682808895 0.0203125837985937 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/HLA-DPA1/C1QC/C1QA 10 GO:0097421 liver regeneration 4/308 35/18722 0.00251624504213384 0.0218052959312811 SRSF5/CEBPB/EGFR/RPS15 4 GO:0016045 detection of bacterium 3/308 17/18722 0.00252674499020599 0.0218052959312811 HLA-B/HLA-A/HLA-DRB1 3 GO:0042053 regulation of dopamine metabolic process 3/308 17/18722 0.00252674499020599 0.0218052959312811 SNCA/COMT/NR4A2 3 GO:0042069 regulation of catecholamine metabolic process 3/308 17/18722 0.00252674499020599 0.0218052959312811 SNCA/COMT/NR4A2 3 GO:0090083 regulation of inclusion body assembly 3/308 17/18722 0.00252674499020599 0.0218052959312811 HSPA1A/HSPA1B/DNAJB6 3 GO:0019724 B cell mediated immunity 10/308 210/18722 0.00258295761847739 0.0222401958906285 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/HLA-DPA1/C1QC/C1QA 10 GO:0050728 negative regulation of inflammatory response 9/308 176/18722 0.00260012128861028 0.0223376712052968 HLA-DRB1/KLF4/ZFP36/TNFAIP3/PTGER4/SOCS3/SERPINF1/METRNL/APOE 9 GO:0051052 regulation of DNA metabolic process 14/308 359/18722 0.00261263328013837 0.022394836390065 KLF4/DUSP1/UBE2B/SUB1/PPP4C/PTGES3/HSP90AB1/EGFR/HNRNPA1/NPM1/HMGB1/HNRNPU/PKIB/HSP90AA1 14 GO:0098586 cellular response to virus 6/308 84/18722 0.00262063844212838 0.0224132008148922 IFI6/OAS1/IFIH1/OAS3/HSP90AA1/CXCL10 6 GO:0044106 cellular amine metabolic process 7/308 113/18722 0.00266304516181367 0.022725048333959 SNCA/AOC1/LY6E/COMT/SMS/NR4A2/OAZ1 7 GO:0006457 protein folding 10/308 212/18722 0.00276562895096957 0.0235478830279659 B2M/HSPA1A/TTC1/PTGES3/HSP90AB1/HSPA1B/DNAJB6/HSPH1/DNAJA1/HSP90AA1 10 GO:0001656 metanephros development 6/308 85/18722 0.00278152632826351 0.0236306114510031 EGR1/BASP1/STAT1/CTSH/FBN1/HES1 6 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 4/308 36/18722 0.00279459957507888 0.0236366242821384 HLA-DRB1/MPC2/SRI/RAC1 4 GO:0060338 regulation of type I interferon-mediated signaling pathway 4/308 36/18722 0.00279459957507888 0.0236366242821384 ISG15/OAS1/HSP90AB1/OAS3 4 GO:0001836 release of cytochrome c from mitochondria 5/308 59/18722 0.00282590457453494 0.0237961083445971 JUN/IFI6/SOD2/BID/TNFSF10 5 GO:0032768 regulation of monooxygenase activity 5/308 59/18722 0.00282590457453494 0.0237961083445971 SNCA/IL1B/EGFR/APOE/CALM1 5 GO:2000117 negative regulation of cysteine-type endopeptidase activity 6/308 86/18722 0.00294969968525796 0.024783960212618 KLF4/SNCA/IFI6/PRDX3/HERPUD1/DNAJB6 6 GO:0002544 chronic inflammatory response 3/308 18/18722 0.00299545512599224 0.0249349192486745 TNFAIP3/S100A8/S100A9 3 GO:0006595 polyamine metabolic process 3/308 18/18722 0.00299545512599224 0.0249349192486745 AOC1/SMS/OAZ1 3 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 3/308 18/18722 0.00299545512599224 0.0249349192486745 HLA-B/HLA-A/HLA-F 3 GO:0150078 positive regulation of neuroinflammatory response 3/308 18/18722 0.00299545512599224 0.0249349192486745 CCL3/NUPR1/IL1B 3 GO:0046700 heterocycle catabolic process 16/308 445/18722 0.00300027801579656 0.0249349192486745 HSPA1A/ZFP36/OAS2/BLVRA/RNASET2/SSB/HNRNPM/TYMP/CIRBP/HSPA1B/DNASE2/NPM1/EIF3E/HNRNPU/DDX5/APOBEC3A 16 GO:0048660 regulation of smooth muscle cell proliferation 9/308 180/18722 0.00302188791907512 0.0250600379926771 JUN/KLF4/TNFAIP3/SOD2/COMT/EGFR/TRIB1/STAT1/APOE 9 GO:0031663 lipopolysaccharide-mediated signaling pathway 5/308 60/18722 0.00304206326148802 0.0251690304721702 NFKBIA/CCL3/TNFAIP3/IL1B/TRIB1 5 GO:0046651 lymphocyte proliferation 12/308 288/18722 0.00304819804044332 0.0251690304721702 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/GPR183/PSMB10/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 12 GO:0033120 positive regulation of RNA splicing 4/308 37/18722 0.00309331887049277 0.025431737724503 SRSF5/HSPA1A/NCL/CIRBP 4 GO:0042401 cellular biogenic amine biosynthetic process 4/308 37/18722 0.00309331887049277 0.025431737724503 SNCA/SMS/NR4A2/OAZ1 4 GO:0010959 regulation of metal ion transport 15/308 406/18722 0.00311262270130815 0.0255355291568692 B2M/CCL3/YWHAH/SNCA/SARAF/CCL4/VAMP2/GLRX/CXCR4/SRI/C4orf3/FXYD3/CALM1/VMP1/CXCL10 15 GO:0001776 leukocyte homeostasis 6/308 87/18722 0.00312536060447559 0.0255572683565569 TSC22D3/TNFAIP3/GPR183/TNFSF13B/HMGB1/ANXA1 6 GO:0045766 positive regulation of angiogenesis 9/308 181/18722 0.00313532797782505 0.0255572683565569 KLF4/RHOB/CXCL8/IL1B/HK2/CXCR4/BTG1/HMGB1/CTSH 9 GO:1904018 positive regulation of vasculature development 9/308 181/18722 0.00313532797782505 0.0255572683565569 KLF4/RHOB/CXCL8/IL1B/HK2/CXCR4/BTG1/HMGB1/CTSH 9 GO:0140694 non-membrane-bounded organelle assembly 14/308 367/18722 0.00318429247751222 0.0258514139434908 CHMP1B/CHMP5/HSPA1A/RPS28/SBDS/CIRBP/KRT8/HSPA1B/RPS27/NPM1/RPL3/HNRNPU/RPS27L/RPS15 14 GO:0034655 nucleobase-containing compound catabolic process 15/308 407/18722 0.00318493747512011 0.0258514139434908 HSPA1A/ZFP36/OAS2/RNASET2/SSB/HNRNPM/TYMP/CIRBP/HSPA1B/DNASE2/NPM1/EIF3E/HNRNPU/DDX5/APOBEC3A 15 GO:0010498 proteasomal protein catabolic process 17/308 490/18722 0.00324135609056175 0.0262536108775796 HSPA1A/UBE2B/GABARAPL2/NUPR1/PSMB10/HSP90AB1/IFI27/TRIB1/HERPUD1/SDCBP/PSMB8/PSME2/SUMO2/HSPA1B/PSMB9/APOE/UBB 17 GO:0032943 mononuclear cell proliferation 12/308 291/18722 0.00331369089012525 0.0267827489914352 HLA-A/HLA-DRB1/CEBPB/HLA-DPB1/IL1B/GPR183/PSMB10/HLA-DPA1/TNFSF13B/HMGB1/HES1/ANXA1 12 GO:0006413 translational initiation 7/308 118/18722 0.0033923523350257 0.0273030799511647 PPP1R15A/EIF1B/PAIP2/EIF2AK2/EIF4A2/NPM1/EIF3E 7 GO:0009308 amine metabolic process 7/308 118/18722 0.0033923523350257 0.0273030799511647 SNCA/AOC1/LY6E/COMT/SMS/NR4A2/OAZ1 7 GO:0009309 amine biosynthetic process 4/308 38/18722 0.00341310683607245 0.0273334498898214 SNCA/SMS/NR4A2/OAZ1 4 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 4/308 38/18722 0.00341310683607245 0.0273334498898214 HSPA1A/BNIP3L/VDAC2/BID 4 GO:0044270 cellular nitrogen compound catabolic process 16/308 451/18722 0.00341757495352724 0.0273334498898214 HSPA1A/ZFP36/OAS2/BLVRA/RNASET2/SSB/HNRNPM/TYMP/CIRBP/HSPA1B/DNASE2/NPM1/EIF3E/HNRNPU/DDX5/APOBEC3A 16 GO:0048659 smooth muscle cell proliferation 9/308 184/18722 0.0034959084049475 0.0278726485953006 JUN/KLF4/TNFAIP3/SOD2/COMT/EGFR/TRIB1/STAT1/APOE 9 GO:0002716 negative regulation of natural killer cell mediated immunity 3/308 19/18722 0.00351415553830365 0.0278726485953006 HLA-B/HLA-A/HLA-F 3 GO:0046782 regulation of viral transcription 3/308 19/18722 0.00351415553830365 0.0278726485953006 ZFP36/IFITM3/LARP7 3 GO:0070262 peptidyl-serine dephosphorylation 3/308 19/18722 0.00351415553830365 0.0278726485953006 PPP1R15A/DUSP1/SWAP70 3 GO:0043433 negative regulation of DNA-binding transcription factor activity 9/308 185/18722 0.00362308117658396 0.0286771000788416 NFKBIA/KLF4/TMSB4X/NUPR1/TNFAIP3/SRI/TRIB1/TAX1BP1/HES1 9 GO:0035304 regulation of protein dephosphorylation 6/308 90/18722 0.00369930430993153 0.0292199181340253 PPP1R15A/SWAP70/ENSA/CAMTA1/HSP90AB1/CALM1 6 GO:0098754 detoxification 8/308 152/18722 0.0037228479512128 0.0292879686342263 SOD2/PRDX3/GLRX/HBA2/APOE/HBA1/S100A9/PRDX1 8 GO:0072655 establishment of protein localization to mitochondrion 7/308 120/18722 0.00372324163124091 0.0292879686342263 BNIP3L/HK2/RALA/BID/DNAJA1/HSP90AA1/CALM1 7 GO:0045622 regulation of T-helper cell differentiation 4/308 39/18722 0.00375465607098615 0.0293514060316742 HLA-DRB1/HLA-DRA/NFKBIZ/ANXA1 4 GO:0051084 'de novo' posttranslational protein folding 4/308 39/18722 0.00375465607098615 0.0293514060316742 HSPA1A/PTGES3/HSPA1B/HSPH1 4 GO:0046902 regulation of mitochondrial membrane permeability 5/308 63/18722 0.00376201646757006 0.0293514060316742 HSPA1A/BNIP3L/HK2/VDAC2/BID 5 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 5/308 63/18722 0.00376201646757006 0.0293514060316742 PPP1R15A/CEBPB/HSPA1A/TXNDC12/HERPUD1 5 GO:0002253 activation of immune response 14/308 375/18722 0.0038546589818126 0.0300129557789604 HLA-A/HLA-DRB1/PLSCR1/HLA-DPB1/HLA-DQB1/NFKBIZ/IL1B/GBP1/CFD/HMGB1/C1QC/HSP90AA1/LAPTM5/C1QA 14 GO:0042177 negative regulation of protein catabolic process 7/308 121/18722 0.00389761020871023 0.0302856988371935 SNCA/GABARAPL2/HSP90AB1/EGFR/SDCBP/SNX3/TIMP3 7 GO:0001906 cell killing 9/308 188/18722 0.00402650089747586 0.0309816652280018 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/HLA-F/HSP90AB1/CTSH/PRDX1 9 GO:0045670 regulation of osteoclast differentiation 5/308 64/18722 0.00402699102305567 0.0309816652280018 FOS/CCL3/CEBPB/MAFB/FBN1 5 GO:0048247 lymphocyte chemotaxis 5/308 64/18722 0.00402699102305567 0.0309816652280018 CCL3/CCL3L3/CCL4/GPR183/CXCL10 5 GO:0051168 nuclear export 8/308 154/18722 0.00402911186631014 0.0309816652280018 ANP32B/IL1B/SSB/IFI27/SRSF3/HNRNPA1/NPM1/RPS15 8 GO:0051928 positive regulation of calcium ion transport 7/308 122/18722 0.00407810744288901 0.0309816652280018 CCL3/SNCA/CCL4/SRI/CALM1/VMP1/CXCL10 7 GO:0003159 morphogenesis of an endothelium 3/308 20/18722 0.00408442565391392 0.0309816652280018 RHOB/CXCR4/CXCL10 3 GO:0032495 response to muramyl dipeptide 3/308 20/18722 0.00408442565391392 0.0309816652280018 NFKBIA/CHMP5/TNFAIP3 3 GO:0043555 regulation of translation in response to stress 3/308 20/18722 0.00408442565391392 0.0309816652280018 PPP1R15A/EIF2AK2/NPM1 3 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 3/308 20/18722 0.00408442565391392 0.0309816652280018 ISG15/OAS1/OAS3 3 GO:0061154 endothelial tube morphogenesis 3/308 20/18722 0.00408442565391392 0.0309816652280018 RHOB/CXCR4/CXCL10 3 GO:0098543 detection of other organism 3/308 20/18722 0.00408442565391392 0.0309816652280018 HLA-B/HLA-A/HLA-DRB1 3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/308 20/18722 0.00408442565391392 0.0309816652280018 HSPA1A/TXNDC12/HERPUD1 3 GO:0045740 positive regulation of DNA replication 4/308 40/18722 0.00411864710584059 0.0309952517433633 JUN/CACYBP/EGFR/RAC1 4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 4/308 40/18722 0.00411864710584059 0.0309952517433633 SNCA/SRI/CALM1/CXCL10 4 GO:0071276 cellular response to cadmium ion 4/308 40/18722 0.00411864710584059 0.0309952517433633 JUN/FOS/NCF1/EGFR 4 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 4/308 40/18722 0.00411864710584059 0.0309952517433633 HSPA1A/BNIP3L/VDAC2/BID 4 GO:0031330 negative regulation of cellular catabolic process 11/308 262/18722 0.00422907464737788 0.0317637571255907 SNCA/ZFP36/GABARAPL2/NUPR1/HSP90AB1/CIRBP/SDCBP/MCL1/TIMP3/HNRNPU/APOC1 11 GO:0050852 T cell receptor signaling pathway 7/308 123/18722 0.004264868707426 0.0319697903303717 HLA-A/HLA-DRB1/HLA-DPB1/HLA-DQB1/NFKBIZ/GBP1/LAPTM5 7 GO:0090307 mitotic spindle assembly 5/308 65/18722 0.0043050405726859 0.0321994479418144 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:0006913 nucleocytoplasmic transport 12/308 301/18722 0.0043367357069962 0.0321994479418144 NFKBIA/MX2/ANP32B/IL1B/SSB/HSP90AB1/IFI27/SRSF3/HNRNPA1/NPM1/RPS15/TXNIP 12 GO:0051169 nuclear transport 12/308 301/18722 0.0043367357069962 0.0321994479418144 NFKBIA/MX2/ANP32B/IL1B/SSB/HSP90AB1/IFI27/SRSF3/HNRNPA1/NPM1/RPS15/TXNIP 12 GO:0051591 response to cAMP 6/308 93/18722 0.00434799668853344 0.0321994479418144 JUN/FOSB/FOS/DUSP1/STAT1/LDHA 6 GO:1901796 regulation of signal transduction by p53 class mediator 6/308 93/18722 0.00434799668853344 0.0321994479418144 NPM1/SGK1/DDX5/RPL37/RPS15/UBB 6 GO:0002703 regulation of leukocyte mediated immunity 10/308 226/18722 0.00435258807901391 0.0321994479418144 B2M/HLA-B/HLA-A/HLA-DRB1/HLA-DRA/IL1B/HLA-F/BST2/RSAD2/HMGB1 10 GO:0009267 cellular response to starvation 8/308 156/18722 0.00435446366359352 0.0321994479418144 JUN/AOC1/GABARAPL2/COMT/ATF3/EIF2AK2/MAP1LC3B/HNRNPA1 8 GO:0045600 positive regulation of fat cell differentiation 5/308 66/18722 0.00459651109111688 0.0338583080950671 CEBPB/ZFP36/METRNL/HNRNPU/ADIRF 5 GO:0050918 positive chemotaxis 5/308 66/18722 0.00459651109111688 0.0338583080950671 CCL3/HMGB2/CXCL8/HMGB1/CXCL10 5 GO:0032516 positive regulation of phosphoprotein phosphatase activity 3/308 21/18722 0.00470772555748229 0.0346108361658746 PPP1R15A/HSP90AB1/CALM1 3 GO:0007565 female pregnancy 9/308 193/18722 0.00477609031469888 0.0350460523475889 FOSB/FOS/FBLN1/JUNB/IL1B/COMT/PRDX3/IGFBP7/VMP1 9 GO:0061077 chaperone-mediated protein folding 5/308 67/18722 0.00490174685029009 0.0358991919706112 HSPA1A/PTGES3/HSPA1B/DNAJB6/HSPH1 5 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/308 42/18722 0.00491661216819309 0.0359392128470405 JUN/FOS/KLF4/EGR1 4 GO:0034620 cellular response to unfolded protein 6/308 96/18722 0.00507701122102055 0.0369703121865934 PPP1R15A/HSPA1A/ATF3/EIF2AK2/HERPUD1/HSPA1B 6 GO:1901655 cellular response to ketone 6/308 96/18722 0.00507701122102055 0.0369703121865934 KLF2/KLF4/DDIT4/PTGER4/EGFR/SERPINF1 6 GO:0006402 mRNA catabolic process 10/308 232/18722 0.00522112703953354 0.0379474689584349 HSPA1A/ZFP36/SSB/HNRNPM/CIRBP/HSPA1B/NPM1/EIF3E/HNRNPU/DDX5 10 GO:0022408 negative regulation of cell-cell adhesion 9/308 196/18722 0.00527533139813837 0.0381961968467481 HLA-DRB1/KLF4/CEBPB/SWAP70/MYADM/HMGB1/LAPTM5/CD9/ANXA1 9 GO:0071674 mononuclear cell migration 9/308 196/18722 0.00527533139813837 0.0381961968467481 CCL3/CCL3L3/DUSP1/CCL4/GPR183/CXCR4/HMGB1/ANXA1/CXCL10 9 GO:0006458 'de novo' protein folding 4/308 43/18722 0.00535188081214953 0.0382683745249321 HSPA1A/PTGES3/HSPA1B/HSPH1 4 GO:0014002 astrocyte development 4/308 43/18722 0.00535188081214953 0.0382683745249321 EGFR/S100A8/S100A9/C1QA 4 GO:0035794 positive regulation of mitochondrial membrane permeability 4/308 43/18722 0.00535188081214953 0.0382683745249321 HSPA1A/BNIP3L/VDAC2/BID 4 GO:0042088 T-helper 1 type immune response 4/308 43/18722 0.00535188081214953 0.0382683745249321 HLA-DRB1/IL1B/HMGB1/ANXA1 4 GO:0010310 regulation of hydrogen peroxide metabolic process 3/308 22/18722 0.00538540033858579 0.0382683745249321 SNCA/SOD2/RAC1 3 GO:0032727 positive regulation of interferon-alpha production 3/308 22/18722 0.00538540033858579 0.0382683745249321 IFIH1/STAT1/HMGB1 3 GO:0051220 cytoplasmic sequestering of protein 3/308 22/18722 0.00538540033858579 0.0382683745249321 NFKBIA/TMSB4X/SRI 3 GO:0051412 response to corticosterone 3/308 22/18722 0.00538540033858579 0.0382683745249321 FOSB/FOS/CALM1 3 GO:0060713 labyrinthine layer morphogenesis 3/308 22/18722 0.00538540033858579 0.0382683745249321 GRB2/SOCS3/DNAJB6 3 GO:0071359 cellular response to dsRNA 3/308 22/18722 0.00538540033858579 0.0382683745249321 IFIT1/IFIH1/NPM1 3 GO:0042594 response to starvation 9/308 197/18722 0.00545043051485746 0.0386034894188488 JUN/AOC1/ZFP36/GABARAPL2/COMT/ATF3/EIF2AK2/MAP1LC3B/HNRNPA1 9 GO:0051100 negative regulation of binding 8/308 162/18722 0.00545275550253161 0.0386034894188488 B2M/NFKBIA/JUN/IFIT1/TMSB4X/IFIT2/SRI/C4orf3 8 GO:0031667 response to nutrient levels 16/308 474/18722 0.00548485040277578 0.0387589336225726 JUN/AOC1/ZFP36/GABARAPL2/ENSA/SOD2/COMT/ATF3/EIF2AK2/MAP1LC3B/EGFR/HNRNPA1/STAT1/LDHA/APOE/CXCL10 16 GO:0050688 regulation of defense response to virus 5/308 69/18722 0.0055548810678908 0.039181384358942 IFIT1/TNFAIP3/HERC5/STAT1/HSP90AA1 5 GO:0045861 negative regulation of proteolysis 13/308 351/18722 0.00562345513570053 0.0395920239112028 KLF4/SNCA/GABARAPL2/IFI6/PRDX3/HSP90AB1/BST2/HERPUD1/SDCBP/SERPINF1/DNAJB6/TIMP3/ITIH5 13 GO:0050999 regulation of nitric-oxide synthase activity 4/308 44/18722 0.0058121793255952 0.0406959002962463 IL1B/EGFR/APOE/CALM1 4 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 4/308 44/18722 0.0058121793255952 0.0406959002962463 HSPA1A/RSAD2/HSPA1B/HMGB1 4 GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/308 44/18722 0.0058121793255952 0.0406959002962463 PPP1R15A/HSPA1A/TXNDC12/HERPUD1 4 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 8/308 164/18722 0.0058622060914488 0.0409711405623561 HSPA1A/HSP90AB1/TRIB1/HERPUD1/SDCBP/SUMO2/HSPA1B/LAPTM5 8 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 6/308 99/18722 0.00589194047132291 0.0411038109888093 NUPR1/DDIT4/BID/BCL2A1/MCL1/RPS27L 6 GO:0046683 response to organophosphorus 7/308 131/18722 0.00600088818078046 0.041787605674178 JUN/FOSB/FOS/DUSP1/CASP1/STAT1/LDHA 7 GO:0043270 positive regulation of ion transport 11/308 275/18722 0.00604207870041732 0.0419348854014634 CCL3/SNCA/TMSB4X/CEBPB/CCL4/IL1B/GLRX/SRI/CALM1/VMP1/CXCL10 11 GO:0031334 positive regulation of protein-containing complex assembly 10/308 237/18722 0.00604397642066606 0.0419348854014634 SNCA/ISG15/HSPA1A/GRB2/BID/HSPA1B/RAC1/ARPC3/HSP90AA1/IQGAP2 10 GO:0050765 negative regulation of phagocytosis 3/308 23/18722 0.00611868431496222 0.0422996928320082 PLSCR1/SNX3/HMGB1 3 GO:0072677 eosinophil migration 3/308 23/18722 0.00611868431496222 0.0422996928320082 CCL3/CCL4/PTGER4 3 GO:0051054 positive regulation of DNA metabolic process 9/308 201/18722 0.00619623050557673 0.0427584643011189 KLF4/UBE2B/PTGES3/HSP90AB1/EGFR/HNRNPA1/HMGB1/PKIB/HSP90AA1 9 GO:0043112 receptor metabolic process 8/308 166/18722 0.00629465327577985 0.0431500112226217 SNCA/CHMP5/CXCL8/GRB2/SDCBP/APOE/LAPTM5/CD9 8 GO:0035307 positive regulation of protein dephosphorylation 4/308 45/18722 0.00629811830034604 0.0431500112226217 PPP1R15A/CAMTA1/HSP90AB1/CALM1 4 GO:0071364 cellular response to epidermal growth factor stimulus 4/308 45/18722 0.00629811830034604 0.0431500112226217 NCL/ZFP36/EEF1A1/EGFR 4 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 4/308 45/18722 0.00629811830034604 0.0431500112226217 HSPA1A/BNIP3L/VDAC2/BID 4 GO:0019722 calcium-mediated signaling 9/308 202/18722 0.00639440560783956 0.0437313285130065 CCL3/CCL4/CXCL8/CAMTA1/GBP1/CXCR4/EGFR/DEFB1/CALM1 9 GO:0016049 cell growth 16/308 482/18722 0.00640664817487501 0.0437368142366914 HSPA1A/CXCR4/HSP90AB1/BST2/EGFR/IGFBP7/SDCBP/HSPA1B/S100A8/BTG1/NPM1/APOE/SGK1/FN1/HSP90AA1/S100A9 16 GO:0046328 regulation of JNK cascade 7/308 133/18722 0.00650715914470841 0.044264892189004 GADD45B/NCF1/IL1B/EGFR/SDCBP/HMGB1/DNAJA1 7 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 7/308 133/18722 0.00650715914470841 0.044264892189004 HSPA1A/NUPR1/TRIB1/HERPUD1/SUMO2/HSPA1B/LAPTM5 7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7/308 134/18722 0.00677189856371736 0.0459839577426136 HSPA1A/HSP90AB1/TRIB1/HERPUD1/SDCBP/SUMO2/HSPA1B 7 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 3/308 24/18722 0.00690870513505639 0.0464999643157052 HLA-B/HLA-A/HLA-F 3 GO:0006213 pyrimidine nucleoside metabolic process 3/308 24/18722 0.00690870513505639 0.0464999643157052 TYMP/NT5C3A/APOBEC3A 3 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 3/308 24/18722 0.00690870513505639 0.0464999643157052 KLF2/CEBPB/ATF3 3 GO:0051043 regulation of membrane protein ectodomain proteolysis 3/308 24/18722 0.00690870513505639 0.0464999643157052 IL1B/APOE/TIMP3 3 GO:0070841 inclusion body assembly 3/308 24/18722 0.00690870513505639 0.0464999643157052 HSPA1A/HSPA1B/DNAJB6 3 GO:0042274 ribosomal small subunit biogenesis 5/308 73/18722 0.00704123013833895 0.0470827827543025 RPS28/RPS27/NPM1/RPS27L/RPS15 5 GO:0050848 regulation of calcium-mediated signaling 5/308 73/18722 0.00704123013833895 0.0470827827543025 CCL3/CCL4/CAMTA1/GBP1/CALM1 5 GO:1904427 positive regulation of calcium ion transmembrane transport 5/308 73/18722 0.00704123013833895 0.0470827827543025 SNCA/SRI/CALM1/VMP1/CXCL10 5 GO:0002687 positive regulation of leukocyte migration 7/308 135/18722 0.00704455970061759 0.0470827827543025 CCL3/CCL4/CXCL8/SWAP70/RAC1/HMGB1/CXCL10 7 GO:0032760 positive regulation of tumor necrosis factor production 6/308 103/18722 0.00712180597442808 0.0475159934384617 CCL3/OAS1/OAS2/IFIH1/OAS3/HMGB1 6 GO:0042311 vasodilation 4/308 47/18722 0.00734928170211646 0.048863137299463 KLF2/SOD2/EGFR/APOE 4 GO:1900744 regulation of p38MAPK cascade 4/308 47/18722 0.00734928170211646 0.048863137299463 GADD45B/DUSP1/NCF1/IL1B 4 GO:1901215 negative regulation of neuron death 9/308 208/18722 0.00768777372528281 0.0510249287356878 SNCA/CEBPB/SOD2/HLA-F/HSP90AB1/SERPINF1/NR4A2/SET/APOE 9 GO:0060706 cell differentiation involved in embryonic placenta development 3/308 25/18722 0.00775648776289167 0.0512142533981604 SOCS3/KRT8/DNAJB6 3 GO:0098581 detection of external biotic stimulus 3/308 25/18722 0.00775648776289167 0.0512142533981604 HLA-B/HLA-A/HLA-DRB1 3 GO:1901623 regulation of lymphocyte chemotaxis 3/308 25/18722 0.00775648776289167 0.0512142533981604 CCL3/CCL4/CXCL10 3 GO:0031668 cellular response to extracellular stimulus 10/308 246/18722 0.0077764903001078 0.0512577972712278 JUN/FOS/AOC1/GABARAPL2/COMT/ATF3/EIF2AK2/MAP1LC3B/HNRNPA1/NR4A2 10 GO:0032273 positive regulation of protein polymerization 7/308 138/18722 0.00791146621450925 0.0519957413000918 HSPA1A/GRB2/HSPA1B/RAC1/ARPC3/HSP90AA1/IQGAP2 7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 4/308 48/18722 0.0079156477731241 0.0519957413000918 ATF3/BID/TNFSF10/TIMP3 4 GO:0001503 ossification 14/308 408/18722 0.00793620193121413 0.0520413378782704 JUND/CCL3/ISG15/FBN2/JUNB/CEBPB/SRGN/SBDS/PTGER4/EGFR/HNRNPU/DDX5/RPS15/IFITM1 14 GO:0051271 negative regulation of cellular component movement 13/308 367/18722 0.00804724611461279 0.0526791470824738 FBLN1/KLF4/DUSP1/RHOB/PTGER4/BST2/TRIB1/SERPINF1/RAC1/APOE/HMGB1/CD9/IFITM1 13 GO:0002793 positive regulation of peptide secretion 6/308 106/18722 0.00815885784976093 0.0530569355297091 HLA-DRB1/MPC2/SRI/EGFR/S100A8/RAC1 6 GO:0006090 pyruvate metabolic process 6/308 106/18722 0.00815885784976093 0.0530569355297091 MPC2/NUPR1/HK2/DDIT4/LDHA/ALDOA 6 GO:0042116 macrophage activation 6/308 106/18722 0.00815885784976093 0.0530569355297091 JUND/CCL3/SNCA/NMI/HMGB1/C1QA 6 GO:0050866 negative regulation of cell activation 9/308 210/18722 0.00816047033519983 0.0530569355297091 HLA-DRB1/CEBPB/TNFAIP3/HLA-F/APOE/HMGB1/LAPTM5/CD9/ANXA1 9 GO:0007517 muscle organ development 12/308 327/18722 0.00820944661360202 0.0532787795766123 FOS/SAP30/LY6E/NUPR1/ATF3/EGR1/SRI/BASP1/DSP/CHD2/DDX5/CXCL10 12 GO:0071692 protein localization to extracellular region 13/308 368/18722 0.00822246402045546 0.0532787795766123 HLA-DRB1/FBN2/MPC2/ENSA/IL1B/SRI/RAB8A/EGFR/RSAD2/RAC1/APOE/FBN1/ANXA1 13 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 5/308 76/18722 0.00832393359977739 0.0537540509323462 NUPR1/DDIT4/DDX5/RPS27L/UBB 5 GO:2000379 positive regulation of reactive oxygen species metabolic process 5/308 76/18722 0.00832393359977739 0.0537540509323462 SNCA/SOD2/GRB2/EGFR/CBR1 5 GO:0006692 prostanoid metabolic process 4/308 49/18722 0.00850993685809273 0.0542437502423448 IL1B/PTGES3/CBR1/ANXA1 4 GO:0006693 prostaglandin metabolic process 4/308 49/18722 0.00850993685809273 0.0542437502423448 IL1B/PTGES3/CBR1/ANXA1 4 GO:0006953 acute-phase response 4/308 49/18722 0.00850993685809273 0.0542437502423448 PLSCR1/CEBPB/IL1B/FN1 4 GO:0060964 regulation of gene silencing by miRNA 4/308 49/18722 0.00850993685809273 0.0542437502423448 ZFP36/EGFR/NEAT1/DDX5 4 GO:0070849 response to epidermal growth factor 4/308 49/18722 0.00850993685809273 0.0542437502423448 NCL/ZFP36/EEF1A1/EGFR 4 GO:0072091 regulation of stem cell proliferation 4/308 49/18722 0.00850993685809273 0.0542437502423448 FBLN1/HMGB2/EIF2AK2/HNRNPU 4 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/308 49/18722 0.00850993685809273 0.0542437502423448 HMGB2/TNFAIP3/ATF3/TIMP3 4 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 6/308 107/18722 0.00852746374461135 0.0542437502423448 CCL3/OAS1/OAS2/IFIH1/OAS3/HMGB1 6 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 6/308 107/18722 0.00852746374461135 0.0542437502423448 HSPA1A/TRIB1/HERPUD1/SUMO2/HSPA1B/LAPTM5 6 GO:0002407 dendritic cell chemotaxis 3/308 26/18722 0.00866295834821845 0.0546509732099655 GPR183/CXCR4/HMGB1 3 GO:0002418 immune response to tumor cell 3/308 26/18722 0.00866295834821845 0.0546509732099655 HLA-A/HLA-DRB1/HMGB1 3 GO:0032682 negative regulation of chemokine production 3/308 26/18722 0.00866295834821845 0.0546509732099655 KLF4/OAS1/OAS3 3 GO:0034114 regulation of heterotypic cell-cell adhesion 3/308 26/18722 0.00866295834821845 0.0546509732099655 KLF4/IL1B/MYADM 3 GO:0060669 embryonic placenta morphogenesis 3/308 26/18722 0.00866295834821845 0.0546509732099655 GRB2/SOCS3/DNAJB6 3 GO:0009314 response to radiation 15/308 456/18722 0.0088354068375308 0.0556470516307747 JUND/JUN/FOS/DUSP1/RHOB/UBE2B/SOD2/EGR1/GRB2/CIRBP/EGFR/NPM1/ADIRF/ANXA1/CXCL10 15 GO:0001558 regulation of cell growth 14/308 414/18722 0.00895530224988861 0.0563094087192832 HSPA1A/CXCR4/BST2/EGFR/IGFBP7/SDCBP/HSPA1B/S100A8/BTG1/NPM1/APOE/SGK1/FN1/S100A9 14 GO:0010951 negative regulation of endopeptidase activity 10/308 252/18722 0.00912898138774054 0.0572364380803187 KLF4/SNCA/IFI6/PRDX3/BST2/HERPUD1/SERPINF1/DNAJB6/TIMP3/ITIH5 10 GO:0050873 brown fat cell differentiation 4/308 50/18722 0.00913267779989391 0.0572364380803187 CEBPB/ARL4A/METRNL/HNRNPU 4 GO:0097305 response to alcohol 10/308 253/18722 0.00937088939182474 0.0586332408264255 FOSB/KLF2/FOS/CCL3/KLF4/SOD2/PTGER4/IGFBP7/S100A8/CALM1 10 GO:0062012 regulation of small molecule metabolic process 12/308 334/18722 0.00961502375946649 0.0599535311823802 SNCA/TMSB4X/PHLDA2/NUPR1/IL1B/DDIT4/COMT/EGR1/APOE/HMGB1/ANXA1/APOC1 12 GO:0060333 interferon-gamma-mediated signaling pathway 3/308 27/18722 0.00962894798482381 0.0599535311823802 NMI/HSP90AB1/STAT1 3 GO:1903421 regulation of synaptic vesicle recycling 3/308 27/18722 0.00962894798482381 0.0599535311823802 SNCA/VAMP2/CALM1 3 GO:0006636 unsaturated fatty acid biosynthetic process 4/308 51/18722 0.00978438211646097 0.0608222647662281 IL1B/PTGES3/CBR1/ANXA1 4 GO:0007611 learning or memory 10/308 255/18722 0.00986939382296621 0.06115185183987 B2M/JUN/FOS/CEBPB/PAIP2/COMT/EGFR/SERPINF1/APOE/SGK1 10 GO:0051924 regulation of calcium ion transport 10/308 255/18722 0.00986939382296621 0.06115185183987 CCL3/SNCA/SARAF/CCL4/CXCR4/SRI/C4orf3/CALM1/VMP1/CXCL10 10 GO:0071897 DNA biosynthetic process 8/308 180/18722 0.0100332398168791 0.0620664657280402 KLF4/DUSP1/PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 8 GO:0050890 cognition 11/308 296/18722 0.0102046475535276 0.0629231735437678 B2M/JUN/FOS/CEBPB/HLA-DRA/PAIP2/COMT/EGFR/SERPINF1/APOE/SGK1 11 GO:0051258 protein polymerization 11/308 296/18722 0.0102046475535276 0.0629231735437678 SNCA/TMSB4X/HSPA1A/VDAC2/GRB2/HSPA1B/RAC1/MYADM/ARPC3/HSP90AA1/IQGAP2 11 GO:0043524 negative regulation of neuron apoptotic process 7/308 145/18722 0.0102374414198044 0.0630237335715172 SNCA/CEBPB/SOD2/HSP90AB1/NR4A2/SET/APOE 7 GO:0032640 tumor necrosis factor production 8/308 181/18722 0.0103522183990319 0.0634420315368846 CCL3/ZFP36/TNFAIP3/OAS1/OAS2/IFIH1/OAS3/HMGB1 8 GO:0032680 regulation of tumor necrosis factor production 8/308 181/18722 0.0103522183990319 0.0634420315368846 CCL3/ZFP36/TNFAIP3/OAS1/OAS2/IFIH1/OAS3/HMGB1 8 GO:0051346 negative regulation of hydrolase activity 13/308 379/18722 0.0103551733400513 0.0634420315368846 PPP1R15A/KLF4/SNCA/IFI6/PRDX3/BST2/HERPUD1/SERPINF1/DNAJB6/TIMP3/ITIH5/ANXA1/APOC1 13 GO:0043392 negative regulation of DNA binding 4/308 52/18722 0.0104655437578453 0.0638505258827455 NFKBIA/JUN/TMSB4X/SRI 4 GO:0060147 regulation of posttranscriptional gene silencing 4/308 52/18722 0.0104655437578453 0.0638505258827455 ZFP36/EGFR/NEAT1/DDX5 4 GO:0072594 establishment of protein localization to organelle 14/308 422/18722 0.010471953891834 0.0638505258827455 NFKBIA/BNIP3L/TNFAIP3/HK2/RALA/HSP90AB1/BID/HERPUD1/DNAJA1/GCC2/HSP90AA1/LAPTM5/CALM1/TXNIP 14 GO:0002526 acute inflammatory response 6/308 112/18722 0.0105513884179854 0.064232417073182 PLSCR1/CEBPB/NUPR1/IL1B/S100A8/FN1 6 GO:0002313 mature B cell differentiation involved in immune response 3/308 28/18722 0.0106551963598196 0.0644538222841619 IRF8/GPR183/LGALS1 3 GO:0002507 tolerance induction 3/308 28/18722 0.0106551963598196 0.0644538222841619 HLA-B/TNFAIP3/HMGB1 3 GO:0010818 T cell chemotaxis 3/308 28/18722 0.0106551963598196 0.0644538222841619 CCL3/GPR183/CXCL10 3 GO:0045671 negative regulation of osteoclast differentiation 3/308 28/18722 0.0106551963598196 0.0644538222841619 CCL3/MAFB/FBN1 3 GO:0007568 aging 12/308 339/18722 0.010728657776036 0.0647956693171971 JUND/B2M/JUN/FOS/SNCA/SOD2/CACYBP/GRB2/SERPINF1/BCL2A1/NPM1/C1QA 12 GO:0006096 glycolytic process 5/308 81/18722 0.0108069681257348 0.064960753372145 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0048708 astrocyte differentiation 5/308 81/18722 0.0108069681257348 0.064960753372145 EGFR/S100A8/HES1/S100A9/C1QA 5 GO:0071260 cellular response to mechanical stimulus 5/308 81/18722 0.0108069681257348 0.064960753372145 CASP1/IL1B/PTGER4/EGFR/RAC1 5 GO:0044706 multi-multicellular organism process 9/308 220/18722 0.0108635207374089 0.0651981786171339 FOSB/FOS/FBLN1/JUNB/IL1B/COMT/PRDX3/IGFBP7/VMP1 9 GO:0001889 liver development 7/308 147/18722 0.0109849283573415 0.0657401957683762 SRSF5/CEBPB/TNFAIP3/EGFR/RPS15/HES1/ANXA1 7 GO:0010968 regulation of microtubule nucleation 2/308 10/18722 0.0111257930060527 0.0657401957683762 HSPA1A/HSPA1B 2 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 2/308 10/18722 0.0111257930060527 0.0657401957683762 EIF2AK2/NPM1 2 GO:0031340 positive regulation of vesicle fusion 2/308 10/18722 0.0111257930060527 0.0657401957683762 SNCA/ANXA1 2 GO:0032070 regulation of deoxyribonuclease activity 2/308 10/18722 0.0111257930060527 0.0657401957683762 NPM1/HMGB1 2 GO:0035747 natural killer cell chemotaxis 2/308 10/18722 0.0111257930060527 0.0657401957683762 CCL3/CCL4 2 GO:0072203 cell proliferation involved in metanephros development 2/308 10/18722 0.0111257930060527 0.0657401957683762 EGR1/STAT1 2 GO:0072378 blood coagulation, fibrin clot formation 2/308 10/18722 0.0111257930060527 0.0657401957683762 FBLN1/FN1 2 GO:1904896 ESCRT complex disassembly 2/308 10/18722 0.0111257930060527 0.0657401957683762 CHMP1B/CHMP5 2 GO:1904903 ESCRT III complex disassembly 2/308 10/18722 0.0111257930060527 0.0657401957683762 CHMP1B/CHMP5 2 GO:0007566 embryo implantation 4/308 53/18722 0.0111766388954059 0.0658371194100719 FBLN1/IL1B/IGFBP7/VMP1 4 GO:0060966 regulation of gene silencing by RNA 4/308 53/18722 0.0111766388954059 0.0658371194100719 ZFP36/EGFR/NEAT1/DDX5 4 GO:0006757 ATP generation from ADP 5/308 82/18722 0.0113580753741505 0.0664826332066735 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 5/308 82/18722 0.0113580753741505 0.0664826332066735 HMGB2/TNFAIP3/ATF3/BID/TIMP3 5 GO:1905897 regulation of response to endoplasmic reticulum stress 5/308 82/18722 0.0113580753741505 0.0664826332066735 PPP1R15A/HSPA1A/NUPR1/TXNDC12/HERPUD1 5 GO:0014074 response to purine-containing compound 7/308 148/18722 0.0113731734546598 0.0664826332066735 JUN/FOSB/FOS/DUSP1/CASP1/STAT1/LDHA 7 GO:0070507 regulation of microtubule cytoskeleton organization 7/308 148/18722 0.0113731734546598 0.0664826332066735 SNCA/CHMP1B/CHMP5/HSPA1A/HSPA1B/RAC1/HNRNPU 7 GO:1901800 positive regulation of proteasomal protein catabolic process 6/308 114/18722 0.0114490300950019 0.0667944832186487 HSPA1A/NUPR1/TRIB1/HERPUD1/SUMO2/HSPA1B 6 GO:0042063 gliogenesis 11/308 301/18722 0.0114614650775395 0.0667944832186487 CCL3/IL1B/GPR183/CXCR4/EGFR/S100A8/CD9/HES1/S100A9/ANXA1/C1QA 11 GO:0071549 cellular response to dexamethasone stimulus 3/308 29/18722 0.0117423552966614 0.0682234411840979 DDIT4/EGFR/SERPINF1 3 GO:0090025 regulation of monocyte chemotaxis 3/308 29/18722 0.0117423552966614 0.0682234411840979 DUSP1/HMGB1/CXCL10 3 GO:0010466 negative regulation of peptidase activity 10/308 262/18722 0.0117748562004508 0.0683062977187088 KLF4/SNCA/IFI6/PRDX3/BST2/HERPUD1/SERPINF1/DNAJB6/TIMP3/ITIH5 10 GO:0002274 myeloid leukocyte activation 9/308 223/18722 0.0117923506393795 0.0683062977187088 JUND/CCL3/SNCA/PLSCR1/CXCL8/VAMP2/NMI/HMGB1/C1QA 9 GO:0006584 catecholamine metabolic process 4/308 54/18722 0.0119181257416953 0.068618967937502 SNCA/LY6E/COMT/NR4A2 4 GO:0009712 catechol-containing compound metabolic process 4/308 54/18722 0.0119181257416953 0.068618967937502 SNCA/LY6E/COMT/NR4A2 4 GO:0010524 positive regulation of calcium ion transport into cytosol 4/308 54/18722 0.0119181257416953 0.068618967937502 SNCA/SRI/CALM1/CXCL10 4 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 4/308 54/18722 0.0119181257416953 0.068618967937502 JUN/FOS/KLF4/EGR1 4 GO:0071706 tumor necrosis factor superfamily cytokine production 8/308 186/18722 0.0120610727700368 0.0691296569712903 CCL3/ZFP36/TNFAIP3/OAS1/OAS2/IFIH1/OAS3/HMGB1 8 GO:1902115 regulation of organelle assembly 8/308 186/18722 0.0120610727700368 0.0691296569712903 CHMP1B/CHMP5/HSPA1A/NUPR1/SDCBP/HSPA1B/NPM1/HNRNPU 8 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 8/308 186/18722 0.0120610727700368 0.0691296569712903 CCL3/ZFP36/TNFAIP3/OAS1/OAS2/IFIH1/OAS3/HMGB1 8 GO:0061008 hepaticobiliary system development 7/308 150/18722 0.0121793388950616 0.0697030128679946 SRSF5/CEBPB/TNFAIP3/EGFR/RPS15/HES1/ANXA1 7 GO:0032868 response to insulin 10/308 264/18722 0.0123672236088712 0.0706724900698277 SRSF5/SRSF4/IL1B/VAMP2/EGR1/GRB2/RAB8A/STAT1/SOCS3/TNFSF10 10 GO:0035967 cellular response to topologically incorrect protein 6/308 116/18722 0.0123992985434061 0.0707500273603603 PPP1R15A/HSPA1A/ATF3/EIF2AK2/HERPUD1/HSPA1B 6 GO:1904064 positive regulation of cation transmembrane transport 7/308 151/18722 0.0125975258032608 0.0717739808433175 SNCA/TMSB4X/GLRX/SRI/CALM1/VMP1/CXCL10 7 GO:0031113 regulation of microtubule polymerization 4/308 55/18722 0.0126904443996526 0.0720885125406715 SNCA/HSPA1A/HSPA1B/RAC1 4 GO:0043331 response to dsRNA 4/308 55/18722 0.0126904443996526 0.0720885125406715 NFKBIA/IFIT1/IFIH1/NPM1 4 GO:0046825 regulation of protein export from nucleus 3/308 30/18722 0.0128909921945866 0.0727082472096872 ANP32B/IL1B/IFI27 3 GO:0060674 placenta blood vessel development 3/308 30/18722 0.0128909921945866 0.0727082472096872 JUNB/SOCS3/HES1 3 GO:1903579 negative regulation of ATP metabolic process 3/308 30/18722 0.0128909921945866 0.0727082472096872 SNCA/NUPR1/DDIT4 3 GO:2000637 positive regulation of gene silencing by miRNA 3/308 30/18722 0.0128909921945866 0.0727082472096872 ZFP36/EGFR/DDX5 3 GO:0002702 positive regulation of production of molecular mediator of immune response 6/308 117/18722 0.012894635523978 0.0727082472096872 B2M/HLA-A/IL1B/HLA-F/RSAD2/LAPTM5 6 GO:0042391 regulation of membrane potential 14/308 434/18722 0.0131167211440902 0.0737811840348793 JUN/YWHAH/SNCA/BNIP3L/CASP1/IFI6/SOD2/PRDX3/GLRX/SRI/BID/DSP/UBB/CALM1 14 GO:0071277 cellular response to calcium ion 5/308 85/18722 0.0131255753523742 0.0737811840348793 JUND/FOSB/FOS/JUNB/CACYBP 5 GO:0007613 memory 6/308 118/18722 0.0134036864091005 0.0737811840348793 CEBPB/PAIP2/COMT/SERPINF1/APOE/SGK1 6 GO:0002357 defense response to tumor cell 2/308 11/18722 0.0134516048318888 0.0737811840348793 KLF4/LAPTM5 2 GO:0034115 negative regulation of heterotypic cell-cell adhesion 2/308 11/18722 0.0134516048318888 0.0737811840348793 KLF4/MYADM 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/308 11/18722 0.0134516048318888 0.0737811840348793 RSAD2/HMGB1 2 GO:0035457 cellular response to interferon-alpha 2/308 11/18722 0.0134516048318888 0.0737811840348793 IFIT3/IFIT2 2 GO:0035581 sequestering of extracellular ligand from receptor 2/308 11/18722 0.0134516048318888 0.0737811840348793 FBN2/FBN1 2 GO:0039530 MDA-5 signaling pathway 2/308 11/18722 0.0134516048318888 0.0737811840348793 IFIH1/OAS3 2 GO:0042416 dopamine biosynthetic process 2/308 11/18722 0.0134516048318888 0.0737811840348793 SNCA/NR4A2 2 GO:0045657 positive regulation of monocyte differentiation 2/308 11/18722 0.0134516048318888 0.0737811840348793 JUN/HLA-DRB1 2 GO:0046598 positive regulation of viral entry into host cell 2/308 11/18722 0.0134516048318888 0.0737811840348793 HLA-DRB1/LGALS1 2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 2/308 11/18722 0.0134516048318888 0.0737811840348793 SRI/CALM1 2 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 2/308 11/18722 0.0134516048318888 0.0737811840348793 KLF4/MYADM 2 GO:0075294 positive regulation by symbiont of entry into host 2/308 11/18722 0.0134516048318888 0.0737811840348793 HLA-DRB1/LGALS1 2 GO:0098883 synapse pruning 2/308 11/18722 0.0134516048318888 0.0737811840348793 C1QC/C1QA 2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 2/308 11/18722 0.0134516048318888 0.0737811840348793 SRI/CALM1 2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/308 11/18722 0.0134516048318888 0.0737811840348793 CEBPB/ATF3 2 GO:2000644 regulation of receptor catabolic process 2/308 11/18722 0.0134516048318888 0.0737811840348793 APOE/LAPTM5 2 GO:0046456 icosanoid biosynthetic process 4/308 56/18722 0.013494016739759 0.0739077736333789 IL1B/PTGES3/CBR1/ANXA1 4 GO:0050708 regulation of protein secretion 10/308 268/18722 0.0136190986767436 0.0744861434065678 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RSAD2/RAC1/APOE/ANXA1 10 GO:0001649 osteoblast differentiation 9/308 229/18722 0.0138265039070259 0.0755124634808002 JUND/CCL3/FBN2/JUNB/CEBPB/HNRNPU/DDX5/RPS15/IFITM1 9 GO:0032409 regulation of transporter activity 11/308 310/18722 0.0140181185198263 0.0764497390888671 YWHAH/SNCA/TMSB4X/VAMP2/GLRX/SRI/C4orf3/SGK1/FXYD3/CALM1/VMP1 11 GO:0033238 regulation of cellular amine metabolic process 3/308 31/18722 0.0141015933670985 0.0766861898185169 SNCA/COMT/NR4A2 3 GO:0060148 positive regulation of posttranscriptional gene silencing 3/308 31/18722 0.0141015933670985 0.0766861898185169 ZFP36/EGFR/DDX5 3 GO:0033619 membrane protein proteolysis 4/308 57/18722 0.0143292463038598 0.0777031327938382 IL1B/APOE/TIMP3/CTSH 4 GO:1900024 regulation of substrate adhesion-dependent cell spreading 4/308 57/18722 0.0143292463038598 0.0777031327938382 FBLN1/GBP1/RAC1/MYADM 4 GO:0019915 lipid storage 5/308 87/18722 0.0144017862659687 0.0778755712797714 NFKBIA/PLIN2/IL1B/APOE/MEST 5 GO:0051262 protein tetramerization 5/308 87/18722 0.0144017862659687 0.0778755712797714 B2M/HLA-DRB1/SNCA/SOD2/ALDOA 5 GO:0007052 mitotic spindle organization 6/308 120/18722 0.014463653148077 0.0779894865798283 CHMP1B/CHMP5/HSPA1A/SBDS/HSPA1B/HNRNPU 6 GO:0071901 negative regulation of protein serine/threonine kinase activity 6/308 120/18722 0.014463653148077 0.0779894865798283 DUSP1/TNFAIP3/IL1B/APOE/DNAJA1/PKIB 6 GO:0019932 second-messenger-mediated signaling 11/308 312/18722 0.0146406284129223 0.0788325667923973 CCL3/UBE2B/CCL4/CXCL8/CAMTA1/GBP1/CXCR4/EGFR/APOE/DEFB1/CALM1 11 GO:0002224 toll-like receptor signaling pathway 6/308 121/18722 0.0150149249536092 0.0807342589277747 NFKBIA/TNFAIP3/NMI/OAS1/RSAD2/HMGB1 6 GO:0002763 positive regulation of myeloid leukocyte differentiation 4/308 58/18722 0.0151965182343972 0.0814814715429179 JUN/FOS/HLA-DRB1/TRIB1 4 GO:0043525 positive regulation of neuron apoptotic process 4/308 58/18722 0.0151965182343972 0.0814814715429179 JUN/CCL3/NUPR1/MCL1 4 GO:0051250 negative regulation of lymphocyte activation 7/308 157/18722 0.0153263672853823 0.0816346815546051 HLA-DRB1/CEBPB/TNFAIP3/HLA-F/HMGB1/LAPTM5/ANXA1 7 GO:2000377 regulation of reactive oxygen species metabolic process 7/308 157/18722 0.0153263672853823 0.0816346815546051 SNCA/HK2/SOD2/GRB2/EGFR/CBR1/RAC1 7 GO:0003338 metanephros morphogenesis 3/308 32/18722 0.0153745672820601 0.0816346815546051 BASP1/STAT1/HES1 3 GO:0010039 response to iron ion 3/308 32/18722 0.0153745672820601 0.0816346815546051 B2M/SNCA/C1QA 3 GO:0050850 positive regulation of calcium-mediated signaling 3/308 32/18722 0.0153745672820601 0.0816346815546051 CCL3/CCL4/CAMTA1 3 GO:1900745 positive regulation of p38MAPK cascade 3/308 32/18722 0.0153745672820601 0.0816346815546051 GADD45B/NCF1/IL1B 3 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/308 32/18722 0.0153745672820601 0.0816346815546051 HSPA1A/TXNDC12/HERPUD1 3 GO:0022411 cellular component disassembly 14/308 443/18722 0.0154197126115155 0.0817608339997554 CHMP1B/CHMP5/BNIP3L/SWAP70/GABARAPL2/HK2/DDIT4/MAP1LC3B/DNASE2/SET/C1QC/CALM1/VMP1/C1QA 14 GO:0046330 positive regulation of JNK cascade 5/308 89/18722 0.0157587392901705 0.0830561461487011 GADD45B/NCF1/IL1B/SDCBP/HMGB1 5 GO:0007614 short-term memory 2/308 12/18722 0.0159681578392088 0.0830561461487011 COMT/SERPINF1 2 GO:0033127 regulation of histone phosphorylation 2/308 12/18722 0.0159681578392088 0.0830561461487011 UBE2B/IL1B 2 GO:0042762 regulation of sulfur metabolic process 2/308 12/18722 0.0159681578392088 0.0830561461487011 SNCA/COMT 2 GO:0043129 surfactant homeostasis 2/308 12/18722 0.0159681578392088 0.0830561461487011 OAS1/CTSH 2 GO:0043380 regulation of memory T cell differentiation 2/308 12/18722 0.0159681578392088 0.0830561461487011 HLA-DRB1/HLA-DRA 2 GO:0070493 thrombin-activated receptor signaling pathway 2/308 12/18722 0.0159681578392088 0.0830561461487011 SNCA/IQGAP2 2 GO:0070586 cell-cell adhesion involved in gastrulation 2/308 12/18722 0.0159681578392088 0.0830561461487011 KLF4/MYADM 2 GO:0071635 negative regulation of transforming growth factor beta production 2/308 12/18722 0.0159681578392088 0.0830561461487011 HSP90AB1/FN1 2 GO:0072376 protein activation cascade 2/308 12/18722 0.0159681578392088 0.0830561461487011 FBLN1/FN1 2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 2/308 12/18722 0.0159681578392088 0.0830561461487011 JUN/HSPA1A 2 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 2/308 12/18722 0.0159681578392088 0.0830561461487011 C4orf3/VMP1 2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/308 12/18722 0.0159681578392088 0.0830561461487011 EGFR/DDX5 2 GO:1904667 negative regulation of ubiquitin protein ligase activity 2/308 12/18722 0.0159681578392088 0.0830561461487011 RPL37/RPS15 2 GO:0035306 positive regulation of dephosphorylation 4/308 59/18722 0.0160961992278417 0.0833818016911096 PPP1R15A/CAMTA1/HSP90AB1/CALM1 4 GO:0043407 negative regulation of MAP kinase activity 4/308 59/18722 0.0160961992278417 0.0833818016911096 DUSP1/IL1B/APOE/DNAJA1 4 GO:0051353 positive regulation of oxidoreductase activity 4/308 59/18722 0.0160961992278417 0.0833818016911096 SNCA/IL1B/APOE/CALM1 4 GO:0006091 generation of precursor metabolites and energy 15/308 490/18722 0.0161297934470899 0.0834427609583552 SNCA/PHLDA2/NUPR1/NCF1/HK2/DDIT4/SDHD/PTGES3/ALDH2/TKT/BID/LDHA/HMGB1/ALDOA/UQCR11 15 GO:0071900 regulation of protein serine/threonine kinase activity 12/308 359/18722 0.0162088823115807 0.083512880157915 SNCA/DUSP1/TNFAIP3/IL1B/HERC5/HSP90AB1/EGFR/TRIB1/APOE/DNAJA1/PKIB/CALM1 12 GO:1901653 cellular response to peptide 12/308 359/18722 0.0162088823115807 0.083512880157915 KLF2/KLF4/SRSF5/CHMP5/IL1B/VAMP2/GRB2/RAB8A/STAT1/SOCS3/NR4A2/FBN1 12 GO:2000146 negative regulation of cell motility 12/308 359/18722 0.0162088823115807 0.083512880157915 FBLN1/KLF4/DUSP1/RHOB/PTGER4/BST2/TRIB1/SERPINF1/RAC1/APOE/HMGB1/IFITM1 12 GO:0030901 midbrain development 5/308 90/18722 0.0164681178184199 0.084506864993046 YWHAH/BASP1/NR4A2/CALM1/HES1 5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 5/308 90/18722 0.0164681178184199 0.084506864993046 HSPA1A/TRIB1/HERPUD1/SUMO2/HSPA1B 5 GO:0046031 ADP metabolic process 5/308 90/18722 0.0164681178184199 0.084506864993046 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0002335 mature B cell differentiation 3/308 33/18722 0.0167102477059057 0.0848383492425994 IRF8/GPR183/LGALS1 3 GO:0031116 positive regulation of microtubule polymerization 3/308 33/18722 0.0167102477059057 0.0848383492425994 HSPA1A/HSPA1B/RAC1 3 GO:0032633 interleukin-4 production 3/308 33/18722 0.0167102477059057 0.0848383492425994 HLA-DRB1/CEBPB/CD83 3 GO:0032673 regulation of interleukin-4 production 3/308 33/18722 0.0167102477059057 0.0848383492425994 HLA-DRB1/CEBPB/CD83 3 GO:0036336 dendritic cell migration 3/308 33/18722 0.0167102477059057 0.0848383492425994 GPR183/CXCR4/HMGB1 3 GO:0045920 negative regulation of exocytosis 3/308 33/18722 0.0167102477059057 0.0848383492425994 SNCA/HLA-F/ANXA1 3 GO:0046685 response to arsenic-containing substance 3/308 33/18722 0.0167102477059057 0.0848383492425994 ATF3/HNRNPA1/SERPINF1 3 GO:0071353 cellular response to interleukin-4 3/308 33/18722 0.0167102477059057 0.0848383492425994 HSP90AB1/RPL3/TUBA1B 3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 4/308 60/18722 0.0170286375111527 0.0863401607495183 HNRNPA1/SAP18/HNRNPU/DDX5 4 GO:0022898 regulation of transmembrane transporter activity 10/308 278/18722 0.0171633231665571 0.0869077939943679 YWHAH/SNCA/TMSB4X/VAMP2/GLRX/SRI/C4orf3/FXYD3/CALM1/VMP1 10 GO:0045582 positive regulation of T cell differentiation 5/308 91/18722 0.0171984179734329 0.0869703067624788 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/ANXA1 5 GO:0002791 regulation of peptide secretion 8/308 200/18722 0.0179439486866535 0.0904971402511478 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/S100A8/RAC1 8 GO:0032874 positive regulation of stress-activated MAPK cascade 6/308 126/18722 0.0179910692361825 0.0904971402511478 GADD45B/NCF1/IL1B/EIF2AK2/SDCBP/HMGB1 6 GO:0034113 heterotypic cell-cell adhesion 4/308 61/18722 0.0179941628401366 0.0904971402511478 KLF4/IL1B/DSP/MYADM 4 GO:0010922 positive regulation of phosphatase activity 3/308 34/18722 0.0181088967544149 0.0904971402511478 PPP1R15A/HSP90AB1/CALM1 3 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/308 34/18722 0.0181088967544149 0.0904971402511478 CCL3/SRI/CALM1 3 GO:0032743 positive regulation of interleukin-2 production 3/308 34/18722 0.0181088967544149 0.0904971402511478 CD83/IL1B/ANXA1 3 GO:0032770 positive regulation of monooxygenase activity 3/308 34/18722 0.0181088967544149 0.0904971402511478 IL1B/APOE/CALM1 3 GO:0035308 negative regulation of protein dephosphorylation 3/308 34/18722 0.0181088967544149 0.0904971402511478 PPP1R15A/SWAP70/ENSA 3 GO:0048261 negative regulation of receptor-mediated endocytosis 3/308 34/18722 0.0181088967544149 0.0904971402511478 SDCBP/RAC1/APOC1 3 GO:0032886 regulation of microtubule-based process 9/308 240/18722 0.0182145166832858 0.0909061322195842 SNCA/CHMP1B/CHMP5/HSPA1A/HSPA1B/RAC1/NPM1/HNRNPU/DEFB1 9 GO:0007249 I-kappaB kinase/NF-kappaB signaling 10/308 281/18722 0.0183487739198405 0.0912660038736743 NFKBIA/HLA-DRB1/CASP1/TNFAIP3/IL1B/TRIM22/BST2/STAT1/TNFSF10/LGALS1 10 GO:0002551 mast cell chemotaxis 2/308 13/18722 0.0186685888122452 0.0912660038736743 SWAP70/RAC1 2 GO:0006995 cellular response to nitrogen starvation 2/308 13/18722 0.0186685888122452 0.0912660038736743 GABARAPL2/MAP1LC3B 2 GO:0031392 regulation of prostaglandin biosynthetic process 2/308 13/18722 0.0186685888122452 0.0912660038736743 IL1B/ANXA1 2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 2/308 13/18722 0.0186685888122452 0.0912660038736743 TNFAIP3/TRIB1 2 GO:0032429 regulation of phospholipase A2 activity 2/308 13/18722 0.0186685888122452 0.0912660038736743 EGFR/ANXA1 2 GO:0033700 phospholipid efflux 2/308 13/18722 0.0186685888122452 0.0912660038736743 APOE/APOC1 2 GO:0034135 regulation of toll-like receptor 2 signaling pathway 2/308 13/18722 0.0186685888122452 0.0912660038736743 TNFAIP3/HMGB1 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/308 13/18722 0.0186685888122452 0.0912660038736743 ATF3/TIMP3 2 GO:0043379 memory T cell differentiation 2/308 13/18722 0.0186685888122452 0.0912660038736743 HLA-DRB1/HLA-DRA 2 GO:0043562 cellular response to nitrogen levels 2/308 13/18722 0.0186685888122452 0.0912660038736743 GABARAPL2/MAP1LC3B 2 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/308 13/18722 0.0186685888122452 0.0912660038736743 SRI/CALM1 2 GO:0060670 branching involved in labyrinthine layer morphogenesis 2/308 13/18722 0.0186685888122452 0.0912660038736743 GRB2/SOCS3 2 GO:1900115 extracellular regulation of signal transduction 2/308 13/18722 0.0186685888122452 0.0912660038736743 FBN2/FBN1 2 GO:1900116 extracellular negative regulation of signal transduction 2/308 13/18722 0.0186685888122452 0.0912660038736743 FBN2/FBN1 2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/308 13/18722 0.0186685888122452 0.0912660038736743 ATF3/TIMP3 2 GO:0032088 negative regulation of NF-kappaB transcription factor activity 5/308 93/18722 0.0187227058738306 0.0914136712077322 NFKBIA/KLF4/TMSB4X/TNFAIP3/TAX1BP1 5 GO:0017157 regulation of exocytosis 8/308 202/18722 0.0189272510501573 0.0917763985332645 SNCA/VAMP2/RALA/HLA-F/RAB8A/SDCBP/CALM1/ANXA1 8 GO:0090087 regulation of peptide transport 8/308 202/18722 0.0189272510501573 0.0917763985332645 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/S100A8/RAC1 8 GO:0032613 interleukin-10 production 4/308 62/18722 0.0189930865186119 0.0917763985332645 HLA-DRB1/ISG15/CD83/HMGB1 4 GO:0032615 interleukin-12 production 4/308 62/18722 0.0189930865186119 0.0917763985332645 HLA-B/IRF8/HMGB1/LAPTM5 4 GO:0032653 regulation of interleukin-10 production 4/308 62/18722 0.0189930865186119 0.0917763985332645 HLA-DRB1/ISG15/CD83/HMGB1 4 GO:0032655 regulation of interleukin-12 production 4/308 62/18722 0.0189930865186119 0.0917763985332645 HLA-B/IRF8/HMGB1/LAPTM5 4 GO:0032731 positive regulation of interleukin-1 beta production 4/308 62/18722 0.0189930865186119 0.0917763985332645 CCL3/CASP1/EGR1/HMGB1 4 GO:0032757 positive regulation of interleukin-8 production 4/308 62/18722 0.0189930865186119 0.0917763985332645 HSPA1A/IL1B/HSPA1B/HMGB1 4 GO:0002700 regulation of production of molecular mediator of immune response 7/308 164/18722 0.0190130545745084 0.0917763985332645 B2M/HLA-A/IL1B/HLA-F/BST2/RSAD2/LAPTM5 7 GO:0002790 peptide secretion 9/308 242/18722 0.0191100869398933 0.0921284519183003 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/S100A8/RAC1/ANXA1 9 GO:0032612 interleukin-1 production 6/308 128/18722 0.0192871932326029 0.0925156081910176 CCL3/CASP1/TNFAIP3/EGR1/HMGB1/ANXA1 6 GO:0032652 regulation of interleukin-1 production 6/308 128/18722 0.0192871932326029 0.0925156081910176 CCL3/CASP1/TNFAIP3/EGR1/HMGB1/ANXA1 6 GO:0035303 regulation of dephosphorylation 6/308 128/18722 0.0192871932326029 0.0925156081910176 PPP1R15A/SWAP70/ENSA/CAMTA1/HSP90AB1/CALM1 6 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 6/308 128/18722 0.0192871932326029 0.0925156081910176 GADD45B/NCF1/IL1B/EIF2AK2/SDCBP/HMGB1 6 GO:0018149 peptide cross-linking 3/308 35/18722 0.0195707078524412 0.0931052435630646 DSP/FN1/ANXA1 3 GO:0019068 virion assembly 3/308 35/18722 0.0195707078524412 0.0931052435630646 CHMP1B/CHMP5/APOE 3 GO:0021955 central nervous system neuron axonogenesis 3/308 35/18722 0.0195707078524412 0.0931052435630646 HSP90AB1/NR4A2/HSP90AA1 3 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 3/308 35/18722 0.0195707078524412 0.0931052435630646 CCL3/SRI/CALM1 3 GO:2000403 positive regulation of lymphocyte migration 3/308 35/18722 0.0195707078524412 0.0931052435630646 CCL3/CCL4/CXCL10 3 GO:0032635 interleukin-6 production 7/308 165/18722 0.0195862371404517 0.0931052435630646 KLF2/HLA-B/CEBPB/TNFAIP3/IL1B/IFIH1/HMGB1 7 GO:0032675 regulation of interleukin-6 production 7/308 165/18722 0.0195862371404517 0.0931052435630646 KLF2/HLA-B/CEBPB/TNFAIP3/IL1B/IFIH1/HMGB1 7 GO:0007346 regulation of mitotic cell cycle 14/308 457/18722 0.0196049492723691 0.0931052435630646 KLF4/DUSP1/IL1B/SYF2/BID/EGFR/IK/SDCBP/PSME2/BTG1/HNRNPU/RPS27L/HES1/ANXA1 14 GO:0002704 negative regulation of leukocyte mediated immunity 4/308 63/18722 0.0200257014373266 0.0949221729749188 HLA-B/HLA-A/HLA-F/BST2 4 GO:0006898 receptor-mediated endocytosis 9/308 244/18722 0.02003719424294 0.0949221729749188 B2M/SNCA/CXCL8/GRB2/SDCBP/RAC1/APOE/CD9/APOC1 9 GO:0060538 skeletal muscle organ development 7/308 166/18722 0.0201714012099655 0.095439686665468 FOS/SAP30/NUPR1/ATF3/EGR1/BASP1/DDX5 7 GO:0034767 positive regulation of ion transmembrane transport 7/308 167/18722 0.0207686609355158 0.0980229515512063 SNCA/TMSB4X/GLRX/SRI/CALM1/VMP1/CXCL10 7 GO:1903034 regulation of response to wounding 7/308 167/18722 0.0207686609355158 0.0980229515512063 KLF4/TNFAIP3/CXCR4/APOE/HMGB1/CD9/ANXA1 7 GO:0032507 maintenance of protein location in cell 4/308 64/18722 0.0210922821316114 0.0986480851361992 TMSB4X/SRGN/HK2/HNRNPU 4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 4/308 64/18722 0.0210922821316114 0.0986480851361992 HLA-DRB1/MPC2/SRI/RAC1 4 GO:0051385 response to mineralocorticoid 3/308 36/18722 0.0210958086049287 0.0986480851361992 FOSB/FOS/CALM1 3 GO:0060251 regulation of glial cell proliferation 3/308 36/18722 0.0210958086049287 0.0986480851361992 IL1B/EGFR/HES1 3 GO:0070670 response to interleukin-4 3/308 36/18722 0.0210958086049287 0.0986480851361992 HSP90AB1/RPL3/TUBA1B 3 GO:0000723 telomere maintenance 6/308 131/18722 0.0213485548194693 0.0986480851361992 PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 6 GO:0045089 positive regulation of innate immune response 6/308 131/18722 0.0213485548194693 0.0986480851361992 PLSCR1/HMGB2/NMI/HLA-F/HMGB1/HSP90AA1 6 GO:1904950 negative regulation of establishment of protein localization 6/308 131/18722 0.0213485548194693 0.0986480851361992 IL1B/RSAD2/SNX3/APOE/DNAJA1/ANXA1 6 GO:0002833 positive regulation of response to biotic stimulus 7/308 168/18722 0.0213781289425129 0.0986480851361992 HLA-DRB1/PLSCR1/HMGB2/NMI/HLA-F/HMGB1/HSP90AA1 7 GO:0000054 ribosomal subunit export from nucleus 2/308 14/18722 0.0215462074519295 0.0986480851361992 NPM1/RPS15 2 GO:0002467 germinal center formation 2/308 14/18722 0.0215462074519295 0.0986480851361992 TNFAIP3/TNFSF13B 2 GO:0002475 antigen processing and presentation via MHC class Ib 2/308 14/18722 0.0215462074519295 0.0986480851361992 B2M/HLA-F 2 GO:0006596 polyamine biosynthetic process 2/308 14/18722 0.0215462074519295 0.0986480851361992 SMS/OAZ1 2 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 2/308 14/18722 0.0215462074519295 0.0986480851361992 FBLN1/GBP1 2 GO:0010872 regulation of cholesterol esterification 2/308 14/18722 0.0215462074519295 0.0986480851361992 APOE/APOC1 2 GO:0033750 ribosome localization 2/308 14/18722 0.0215462074519295 0.0986480851361992 NPM1/RPS15 2 GO:0034616 response to laminar fluid shear stress 2/308 14/18722 0.0215462074519295 0.0986480851361992 KLF2/KLF4 2 GO:0042921 glucocorticoid receptor signaling pathway 2/308 14/18722 0.0215462074519295 0.0986480851361992 YWHAH/PTGES3 2 GO:0045820 negative regulation of glycolytic process 2/308 14/18722 0.0215462074519295 0.0986480851361992 NUPR1/DDIT4 2 GO:0048875 chemical homeostasis within a tissue 2/308 14/18722 0.0215462074519295 0.0986480851361992 OAS1/CTSH 2 GO:0060081 membrane hyperpolarization 2/308 14/18722 0.0215462074519295 0.0986480851361992 CASP1/SOD2 2 GO:0061043 regulation of vascular wound healing 2/308 14/18722 0.0215462074519295 0.0986480851361992 TNFAIP3/CXCR4 2 GO:0090715 immunological memory formation process 2/308 14/18722 0.0215462074519295 0.0986480851361992 HLA-DRB1/HLA-DRA 2 GO:0097531 mast cell migration 2/308 14/18722 0.0215462074519295 0.0986480851361992 SWAP70/RAC1 2 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 2/308 14/18722 0.0215462074519295 0.0986480851361992 FBLN1/GBP1 2 GO:0033002 muscle cell proliferation 9/308 248/18722 0.0219882900408142 0.100551713906738 JUN/KLF4/TNFAIP3/SOD2/COMT/EGFR/TRIB1/STAT1/APOE 9 GO:0070167 regulation of biomineral tissue development 5/308 97/18722 0.0220321245048317 0.100631794482642 CCL3/ISG15/FBN2/CEBPB/SRGN 5 GO:0070936 protein K48-linked ubiquitination 4/308 65/18722 0.0221930848567868 0.101125343751485 UBE2B/TNFAIP3/NMI/IFI27 4 GO:0071677 positive regulation of mononuclear cell migration 4/308 65/18722 0.0221930848567868 0.101125343751485 CCL3/CCL4/HMGB1/CXCL10 4 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 9/308 249/18722 0.0224966547556558 0.102386560870086 HLA-DRB1/CASP1/TNFAIP3/IL1B/TRIM22/BST2/STAT1/TNFSF10/LGALS1 9 GO:1902905 positive regulation of supramolecular fiber organization 8/308 209/18722 0.0226723616365807 0.102873000797226 HSPA1A/SWAP70/GRB2/HSPA1B/RAC1/APOE/ARPC3/IQGAP2 8 GO:0031112 positive regulation of microtubule polymerization or depolymerization 3/308 37/18722 0.0226842635814966 0.102873000797226 HSPA1A/HSPA1B/RAC1 3 GO:0032570 response to progesterone 3/308 37/18722 0.0226842635814966 0.102873000797226 FOSB/FOS/TXNIP 3 GO:0010565 regulation of cellular ketone metabolic process 6/308 133/18722 0.022802659343242 0.103287401266841 SNCA/IL1B/COMT/EGR1/ANXA1/APOC1 6 GO:0070301 cellular response to hydrogen peroxide 5/308 98/18722 0.0229150125900418 0.10367348299613 KLF2/KLF4/RHOB/TNFAIP3/ANXA1 5 GO:0046890 regulation of lipid biosynthetic process 7/308 171/18722 0.0232808852166526 0.10508007577717 IL1B/EGR1/IGFBP7/APOE/ASAH1/ANXA1/APOC1 7 GO:0051048 negative regulation of secretion 7/308 171/18722 0.0232808852166526 0.10508007577717 SNCA/IL1B/HLA-F/COMT/RSAD2/APOE/ANXA1 7 GO:0014015 positive regulation of gliogenesis 4/308 66/18722 0.0233283476803784 0.105170133469442 IL1B/CXCR4/EGFR/HES1 4 GO:0061041 regulation of wound healing 6/308 134/18722 0.0235541012547823 0.106062814012995 TNFAIP3/CXCR4/APOE/HMGB1/CD9/ANXA1 6 GO:0006165 nucleoside diphosphate phosphorylation 5/308 99/18722 0.0238204951495482 0.107010285495561 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0110149 regulation of biomineralization 5/308 99/18722 0.0238204951495482 0.107010285495561 CCL3/ISG15/FBN2/CEBPB/SRGN 5 GO:0001678 cellular glucose homeostasis 7/308 172/18722 0.0239402807634013 0.107422175303384 HLA-DRB1/MPC2/HK2/SRI/SERPINF1/RAC1/LGALS1 7 GO:0009595 detection of biotic stimulus 3/308 38/18722 0.0243360770168186 0.108573608673909 HLA-B/HLA-A/HLA-DRB1 3 GO:0032717 negative regulation of interleukin-8 production 3/308 38/18722 0.0243360770168186 0.108573608673909 KLF4/TMSB4X/ANXA1 3 GO:2000279 negative regulation of DNA biosynthetic process 3/308 38/18722 0.0243360770168186 0.108573608673909 DUSP1/HNRNPA1/HNRNPU 3 GO:0072665 protein localization to vacuole 4/308 67/18722 0.0244982905902253 0.108573608673909 TNFAIP3/GBP1/GCC2/LAPTM5 4 GO:0002468 dendritic cell antigen processing and presentation 2/308 15/18722 0.0245944925743148 0.108573608673909 HLA-DRB1/HLA-DRA 2 GO:0015671 oxygen transport 2/308 15/18722 0.0245944925743148 0.108573608673909 HBA2/HBA1 2 GO:0030852 regulation of granulocyte differentiation 2/308 15/18722 0.0245944925743148 0.108573608673909 TRIB1/C1QC 2 GO:0031958 corticosteroid receptor signaling pathway 2/308 15/18722 0.0245944925743148 0.108573608673909 YWHAH/PTGES3 2 GO:0035493 SNARE complex assembly 2/308 15/18722 0.0245944925743148 0.108573608673909 SNCA/VAMP2 2 GO:0051284 positive regulation of sequestering of calcium ion 2/308 15/18722 0.0245944925743148 0.108573608673909 SRI/CALM1 2 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 2/308 15/18722 0.0245944925743148 0.108573608673909 NPM1/RPS15 2 GO:0072075 metanephric mesenchyme development 2/308 15/18722 0.0245944925743148 0.108573608673909 BASP1/STAT1 2 GO:1901841 regulation of high voltage-gated calcium channel activity 2/308 15/18722 0.0245944925743148 0.108573608673909 SRI/CALM1 2 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 2/308 15/18722 0.0245944925743148 0.108573608673909 IL1B/ANXA1 2 GO:0019218 regulation of steroid metabolic process 5/308 100/18722 0.0247487505940186 0.109128573841907 EGR1/IGFBP7/APOE/ASAH1/APOC1 5 GO:0032535 regulation of cellular component size 12/308 382/18722 0.0248730273245448 0.109424146676334 PPP1R15A/TMSB4X/SWAP70/GRB2/HSP90AB1/RAC1/MYADM/NPM1/APOE/FN1/ARPC3/IQGAP2 12 GO:1902903 regulation of supramolecular fiber organization 12/308 382/18722 0.0248730273245448 0.109424146676334 SNCA/TMSB4X/HSPA1A/SWAP70/GRB2/PTGER4/HSPA1B/RAC1/MYADM/APOE/ARPC3/IQGAP2 12 GO:0048568 embryonic organ development 13/308 427/18722 0.025074883182308 0.110185377478119 FBN2/JUNB/CEBPB/PHLDA2/CXCL8/SYF2/GRB2/MAFB/SOCS3/KRT8/DNAJB6/FBN1/HES1 13 GO:0003158 endothelium development 6/308 136/18722 0.0251064502177967 0.110197427304979 RHOB/IL1B/CXCR4/BTG1/MYADM/CXCL10 6 GO:0046939 nucleotide phosphorylation 5/308 101/18722 0.0256999503111572 0.112429074377682 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0050830 defense response to Gram-positive bacterium 5/308 101/18722 0.0256999503111572 0.112429074377682 RPL39/HLA-A/HMGB2/GBP4/DEFB1 5 GO:0042267 natural killer cell mediated cytotoxicity 4/308 68/18722 0.0257031156176025 0.112429074377682 HLA-B/HLA-A/HLA-F/PRDX1 4 GO:0042417 dopamine metabolic process 3/308 39/18722 0.0260511954289713 0.11369146132986 SNCA/COMT/NR4A2 3 GO:0071548 response to dexamethasone 3/308 39/18722 0.0260511954289713 0.11369146132986 DDIT4/EGFR/SERPINF1 3 GO:0010720 positive regulation of cell development 10/308 298/18722 0.0262315203217132 0.114347893032964 IL1B/CXCR4/EGFR/TRIB1/SERPINF1/RAC1/MYADM/FN1/NAP1L1/HES1 10 GO:0031669 cellular response to nutrient levels 8/308 215/18722 0.0262751168862986 0.114407485029977 JUN/AOC1/GABARAPL2/COMT/ATF3/EIF2AK2/MAP1LC3B/HNRNPA1 8 GO:0002377 immunoglobulin production 8/308 216/18722 0.0269121633613681 0.11691613582695 B2M/HLA-DRB1/HLA-DQA1/HLA-DRA/HLA-DPB1/HLA-DQB1/SWAP70/HLA-DPA1 8 GO:0045669 positive regulation of osteoblast differentiation 4/308 69/18722 0.0269430069745078 0.11691613582695 JUND/FBN2/CEBPB/IFITM1 4 GO:0050810 regulation of steroid biosynthetic process 4/308 69/18722 0.0269430069745078 0.11691613582695 EGR1/IGFBP7/APOE/ASAH1 4 GO:0016050 vesicle organization 10/308 300/18722 0.0272969858943804 0.117301231900277 SNCA/CHMP1B/CHMP5/SRGN/SAMD9/VAMP2/RAB8A/SDCBP/SNX3/ANXA1 10 GO:0070374 positive regulation of ERK1 and ERK2 cascade 8/308 217/18722 0.0275598733023378 0.117301231900277 CCL3/HLA-DRB1/CCL3L3/CCL4/GPR183/EGFR/APOE/HMGB1 8 GO:0045598 regulation of fat cell differentiation 6/308 139/18722 0.0275605952793727 0.117301231900277 CEBPB/ZFP36/METRNL/HNRNPU/ADIRF/HES1 6 GO:0009135 purine nucleoside diphosphate metabolic process 5/308 103/18722 0.0276718327354044 0.117301231900277 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0009179 purine ribonucleoside diphosphate metabolic process 5/308 103/18722 0.0276718327354044 0.117301231900277 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0090277 positive regulation of peptide hormone secretion 5/308 103/18722 0.0276718327354044 0.117301231900277 HLA-DRB1/MPC2/SRI/EGFR/RAC1 5 GO:0030336 negative regulation of cell migration 11/308 344/18722 0.0276768110194918 0.117301231900277 KLF4/DUSP1/RHOB/PTGER4/BST2/TRIB1/SERPINF1/RAC1/APOE/HMGB1/IFITM1 11 GO:0009048 dosage compensation by inactivation of X chromosome 2/308 16/18722 0.0278070883866355 0.117301231900277 HNRNPU/XIST 2 GO:0009415 response to water 2/308 16/18722 0.0278070883866355 0.117301231900277 KRT8/CD9 2 GO:0010649 regulation of cell communication by electrical coupling 2/308 16/18722 0.0278070883866355 0.117301231900277 SRI/CALM1 2 GO:0017014 protein nitrosylation 2/308 16/18722 0.0278070883866355 0.117301231900277 S100A8/S100A9 2 GO:0018119 peptidyl-cysteine S-nitrosylation 2/308 16/18722 0.0278070883866355 0.117301231900277 S100A8/S100A9 2 GO:0034138 toll-like receptor 3 signaling pathway 2/308 16/18722 0.0278070883866355 0.117301231900277 TNFAIP3/OAS1 2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 2/308 16/18722 0.0278070883866355 0.117301231900277 LARP7/HNRNPU 2 GO:0034375 high-density lipoprotein particle remodeling 2/308 16/18722 0.0278070883866355 0.117301231900277 APOE/APOC1 2 GO:0035067 negative regulation of histone acetylation 2/308 16/18722 0.0278070883866355 0.117301231900277 SNCA/SET 2 GO:0045838 positive regulation of membrane potential 2/308 16/18722 0.0278070883866355 0.117301231900277 GLRX/BID 2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 2/308 16/18722 0.0278070883866355 0.117301231900277 IL1B/APOE 2 GO:0090336 positive regulation of brown fat cell differentiation 2/308 16/18722 0.0278070883866355 0.117301231900277 METRNL/HNRNPU 2 GO:0097284 hepatocyte apoptotic process 2/308 16/18722 0.0278070883866355 0.117301231900277 BID/KRT8 2 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/308 16/18722 0.0278070883866355 0.117301231900277 VAMP2/RAB8A 2 GO:0072210 metanephric nephron development 3/308 40/18722 0.0278295101578738 0.117301231900277 EGR1/STAT1/HES1 3 GO:0097352 autophagosome maturation 3/308 40/18722 0.0278295101578738 0.117301231900277 MAP1LC3B/CALM1/VMP1 3 GO:0150077 regulation of neuroinflammatory response 3/308 40/18722 0.0278295101578738 0.117301231900277 CCL3/NUPR1/IL1B 3 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 3/308 40/18722 0.0278295101578738 0.117301231900277 SRI/C4orf3/CALM1 3 GO:2000142 regulation of DNA-templated transcription, initiation 3/308 40/18722 0.0278295101578738 0.117301231900277 JUN/SUB1/HMGB1 3 GO:0043410 positive regulation of MAPK cascade 14/308 480/18722 0.0282758443977732 0.119051269969919 CCL3/HLA-DRB1/GADD45B/CCL3L3/CCL4/NCF1/IL1B/GPR183/EIF2AK2/EGFR/SDCBP/APOE/HMGB1/LAPTM5 14 GO:0031333 negative regulation of protein-containing complex assembly 6/308 140/18722 0.028412641461731 0.119495630702088 SNCA/TMSB4X/VDAC2/PTGER4/MYADM/HMGB1 6 GO:0051091 positive regulation of DNA-binding transcription factor activity 9/308 260/18722 0.0286559284910337 0.12038638969365 HSPA1A/IL1B/TRIM22/EIF2AK2/PRDX3/HSPA1B/S100A8/NPM1/S100A9 9 GO:0045621 positive regulation of lymphocyte differentiation 5/308 104/18722 0.0286928227259539 0.120409068365886 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/ANXA1 5 GO:2001020 regulation of response to DNA damage stimulus 8/308 219/18722 0.0288875875690567 0.121093472890903 IER3/PPP4C/BID/EGFR/MCL1/NPM1/HMGB1/DDX5 8 GO:0051222 positive regulation of protein transport 10/308 303/18722 0.0289526590262593 0.121233313753986 HLA-DRB1/MPC2/ANP32B/IL1B/VAMP2/SRI/HSP90AB1/EGFR/RAC1/OAZ1 10 GO:0040013 negative regulation of locomotion 12/308 391/18722 0.0290536816304785 0.121523221962056 FBLN1/KLF4/DUSP1/RHOB/PTGER4/BST2/TRIB1/SERPINF1/RAC1/APOE/HMGB1/IFITM1 12 GO:0010639 negative regulation of organelle organization 11/308 347/18722 0.0292268053355127 0.12211374513406 SNCA/DUSP1/TMSB4X/HSPA1A/SWAP70/NUPR1/HNRNPA1/IK/MYADM/NPM1/HNRNPU 11 GO:1903038 negative regulation of leukocyte cell-cell adhesion 6/308 141/18722 0.0292818843331245 0.12221030983137 HLA-DRB1/KLF4/CEBPB/HMGB1/LAPTM5/ANXA1 6 GO:0002228 natural killer cell mediated immunity 4/308 71/18722 0.0295286373448621 0.122943804684521 HLA-B/HLA-A/HLA-F/PRDX1 4 GO:0031503 protein-containing complex localization 8/308 220/18722 0.0295677410344019 0.122943804684521 TNFAIP2/VAMP2/SSB/RAB8A/SRSF3/NPM1/HNRNPU/RPS15 8 GO:0032733 positive regulation of interleukin-10 production 3/308 41/18722 0.0296708598258932 0.122943804684521 ISG15/CD83/HMGB1 3 GO:0032735 positive regulation of interleukin-12 production 3/308 41/18722 0.0296708598258932 0.122943804684521 IRF8/HMGB1/LAPTM5 3 GO:0050691 regulation of defense response to virus by host 3/308 41/18722 0.0296708598258932 0.122943804684521 TNFAIP3/STAT1/HSP90AA1 3 GO:0070296 sarcoplasmic reticulum calcium ion transport 3/308 41/18722 0.0296708598258932 0.122943804684521 CCL3/SRI/CALM1 3 GO:0010721 negative regulation of cell development 7/308 180/18722 0.0296827443692945 0.122943804684521 B2M/FBLN1/YWHAH/IL1B/GBP1/FBN1/HES1 7 GO:0062207 regulation of pattern recognition receptor signaling pathway 5/308 105/18722 0.0297373714929532 0.12303676538697 HSPA1A/TNFAIP3/RSAD2/HSPA1B/HMGB1 5 GO:2000045 regulation of G1/S transition of mitotic cell cycle 6/308 142/18722 0.0301684373082202 0.124685336031703 KLF4/BID/EGFR/PSME2/RPS27L/ANXA1 6 GO:0006906 vesicle fusion 5/308 106/18722 0.0308056147426162 0.126666028277769 SNCA/SAMD9/VAMP2/RAB8A/ANXA1 5 GO:0009185 ribonucleoside diphosphate metabolic process 5/308 106/18722 0.0308056147426162 0.126666028277769 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0046822 regulation of nucleocytoplasmic transport 5/308 106/18722 0.0308056147426162 0.126666028277769 MX2/ANP32B/IL1B/HSP90AB1/IFI27 5 GO:0050709 negative regulation of protein secretion 4/308 72/18722 0.0308746571036437 0.126666028277769 IL1B/RSAD2/APOE/ANXA1 4 GO:0062013 positive regulation of small molecule metabolic process 6/308 143/18722 0.0310724102520454 0.126666028277769 SNCA/TMSB4X/IL1B/COMT/HMGB1/ANXA1 6 GO:0015833 peptide transport 9/308 264/18722 0.0311637545819192 0.126666028277769 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/S100A8/RAC1/ANXA1 9 GO:0001780 neutrophil homeostasis 2/308 17/18722 0.0311778008394928 0.126666028277769 HMGB1/ANXA1 2 GO:0033151 V(D)J recombination 2/308 17/18722 0.0311778008394928 0.126666028277769 HMGB2/HMGB1 2 GO:0045591 positive regulation of regulatory T cell differentiation 2/308 17/18722 0.0311778008394928 0.126666028277769 HLA-DRB1/HLA-DRA 2 GO:0046827 positive regulation of protein export from nucleus 2/308 17/18722 0.0311778008394928 0.126666028277769 ANP32B/IL1B 2 GO:0060263 regulation of respiratory burst 2/308 17/18722 0.0311778008394928 0.126666028277769 NCF1/RAC1 2 GO:0061952 midbody abscission 2/308 17/18722 0.0311778008394928 0.126666028277769 CHMP1B/CHMP5 2 GO:0090713 immunological memory process 2/308 17/18722 0.0311778008394928 0.126666028277769 HLA-DRB1/HLA-DRA 2 GO:0097067 cellular response to thyroid hormone stimulus 2/308 17/18722 0.0311778008394928 0.126666028277769 LMO2/CTSH 2 GO:1900034 regulation of cellular response to heat 2/308 17/18722 0.0311778008394928 0.126666028277769 IER5/DNAJB6 2 GO:1903540 establishment of protein localization to postsynaptic membrane 2/308 17/18722 0.0311778008394928 0.126666028277769 VAMP2/RAB8A 2 GO:0007015 actin filament organization 13/308 441/18722 0.0314026259359023 0.127443990395918 TMSB4X/RHOB/SWAP70/GRB2/PTGER4/PHACTR1/RAC1/MYADM/MARCKS/ALDOA/ARPC3/IQGAP2/TPM3 13 GO:0021879 forebrain neuron differentiation 3/308 42/18722 0.0315750327226394 0.127777913252473 B2M/UBB/HES1 3 GO:0032689 negative regulation of interferon-gamma production 3/308 42/18722 0.0315750327226394 0.127777913252473 HLA-DRB1/HMGB1/LAPTM5 3 GO:0032970 regulation of actin filament-based process 12/308 396/18722 0.0315851760459292 0.127777913252473 TMSB4X/RHOB/SWAP70/GRB2/SRI/PTGER4/BST2/DSP/RAC1/MYADM/ARPC3/IQGAP2 12 GO:0031532 actin cytoskeleton reorganization 5/308 107/18722 0.0318976809680085 0.128633791498625 RALA/GRB2/PHACTR1/IQGAP2/ANXA1 5 GO:0032526 response to retinoic acid 5/308 107/18722 0.0318976809680085 0.128633791498625 KLF4/DUSP1/IGFBP7/SERPINF1/CTSH 5 GO:0051341 regulation of oxidoreductase activity 5/308 107/18722 0.0318976809680085 0.128633791498625 SNCA/IL1B/EGFR/APOE/CALM1 5 GO:0032732 positive regulation of interleukin-1 production 4/308 73/18722 0.0322563050436614 0.129669667909482 CCL3/CASP1/EGR1/HMGB1 4 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 4/308 73/18722 0.0322563050436614 0.129669667909482 HLA-DRB1/MPC2/SRI/RAC1 4 GO:0072089 stem cell proliferation 4/308 73/18722 0.0322563050436614 0.129669667909482 FBLN1/HMGB2/EIF2AK2/HNRNPU 4 GO:0032984 protein-containing complex disassembly 8/308 224/18722 0.0323986821193614 0.1301052119142 CHMP1B/CHMP5/SWAP70/DDIT4/MAP1LC3B/SET/CALM1/VMP1 8 GO:0022604 regulation of cell morphogenesis 10/308 309/18722 0.0324759403801307 0.130278614977167 CCL3/FBLN1/RHOB/GBP1/CXCR4/RAC1/MYADM/FN1/ALDOA/ANXA1 10 GO:0034446 substrate adhesion-dependent cell spreading 5/308 108/18722 0.0330136914350733 0.132297004566337 FBLN1/GBP1/RAC1/MYADM/FN1 5 GO:0051047 positive regulation of secretion 10/308 310/18722 0.0330912011088075 0.132468755852326 HLA-DRB1/SNCA/MPC2/IL1B/HLA-F/SRI/EGFR/SDCBP/S100A8/RAC1 10 GO:0032412 regulation of ion transmembrane transporter activity 9/308 267/18722 0.0331422762813749 0.132534437472486 YWHAH/TMSB4X/VAMP2/GLRX/SRI/C4orf3/FXYD3/CALM1/VMP1 9 GO:0001709 cell fate determination 3/308 43/18722 0.0335417691159261 0.13357310763561 KLF4/MCL1/HES1 3 GO:0006509 membrane protein ectodomain proteolysis 3/308 43/18722 0.0335417691159261 0.13357310763561 IL1B/APOE/TIMP3 3 GO:0036230 granulocyte activation 3/308 43/18722 0.0335417691159261 0.13357310763561 CCL3/CXCL8/VAMP2 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/308 43/18722 0.0335417691159261 0.13357310763561 NUPR1/DDIT4/RPS27L 3 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 11/308 355/18722 0.0336633030445214 0.133680658334079 JUN/FOS/FBN2/HSPA1A/SUB1/EGR1/HSP90AB1/SDCBP/DDX5/FBN1/HES1 11 GO:0006801 superoxide metabolic process 4/308 74/18722 0.0336736787799418 0.133680658334079 NCF1/SOD2/EGFR/PRDX1 4 GO:0030968 endoplasmic reticulum unfolded protein response 4/308 74/18722 0.0336736787799418 0.133680658334079 PPP1R15A/ATF3/EIF2AK2/HERPUD1 4 GO:0045580 regulation of T cell differentiation 6/308 146/18722 0.0338898936287506 0.13439944330157 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/ANXA1 6 GO:0002643 regulation of tolerance induction 2/308 18/18722 0.0347005940536803 0.13550599700431 HLA-B/HMGB1 2 GO:0007549 dosage compensation 2/308 18/18722 0.0347005940536803 0.13550599700431 HNRNPU/XIST 2 GO:0030730 sequestering of triglyceride 2/308 18/18722 0.0347005940536803 0.13550599700431 PLIN2/IL1B 2 GO:0032785 negative regulation of DNA-templated transcription, elongation 2/308 18/18722 0.0347005940536803 0.13550599700431 LARP7/HNRNPU 2 GO:0034134 toll-like receptor 2 signaling pathway 2/308 18/18722 0.0347005940536803 0.13550599700431 TNFAIP3/HMGB1 2 GO:0034162 toll-like receptor 9 signaling pathway 2/308 18/18722 0.0347005940536803 0.13550599700431 RSAD2/HMGB1 2 GO:0034433 steroid esterification 2/308 18/18722 0.0347005940536803 0.13550599700431 APOE/APOC1 2 GO:0034434 sterol esterification 2/308 18/18722 0.0347005940536803 0.13550599700431 APOE/APOC1 2 GO:0034435 cholesterol esterification 2/308 18/18722 0.0347005940536803 0.13550599700431 APOE/APOC1 2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 2/308 18/18722 0.0347005940536803 0.13550599700431 IL1B/RSAD2 2 GO:0060192 negative regulation of lipase activity 2/308 18/18722 0.0347005940536803 0.13550599700431 ANXA1/APOC1 2 GO:0060716 labyrinthine layer blood vessel development 2/308 18/18722 0.0347005940536803 0.13550599700431 JUNB/HES1 2 GO:0071360 cellular response to exogenous dsRNA 2/308 18/18722 0.0347005940536803 0.13550599700431 IFIT1/IFIH1 2 GO:0072234 metanephric nephron tubule development 2/308 18/18722 0.0347005940536803 0.13550599700431 STAT1/HES1 2 GO:0098877 neurotransmitter receptor transport to plasma membrane 2/308 18/18722 0.0347005940536803 0.13550599700431 VAMP2/RAB8A 2 GO:1904062 regulation of cation transmembrane transport 11/308 357/18722 0.0348431236988097 0.135730409966043 YWHAH/SNCA/TMSB4X/VAMP2/GLRX/SRI/C4orf3/FXYD3/CALM1/VMP1/CXCL10 11 GO:1902850 microtubule cytoskeleton organization involved in mitosis 6/308 147/18722 0.0348645730020021 0.135730409966043 CHMP1B/CHMP5/HSPA1A/SBDS/HSPA1B/HNRNPU 6 GO:1903531 negative regulation of secretion by cell 6/308 147/18722 0.0348645730020021 0.135730409966043 SNCA/IL1B/HLA-F/RSAD2/APOE/ANXA1 6 GO:0045787 positive regulation of cell cycle 10/308 313/18722 0.0349860125856287 0.13606462473536 PLSCR1/UBE2B/NUPR1/IL1B/EGFR/NPM1/HNRNPU/HES1/RPS15A/ANXA1 10 GO:0002698 negative regulation of immune effector process 5/308 110/18722 0.035317993971767 0.136799078980816 HLA-B/HLA-A/HLA-F/BST2/ANXA1 5 GO:0032611 interleukin-1 beta production 5/308 110/18722 0.035317993971767 0.136799078980816 CCL3/CASP1/TNFAIP3/EGR1/HMGB1 5 GO:0032651 regulation of interleukin-1 beta production 5/308 110/18722 0.035317993971767 0.136799078980816 CCL3/CASP1/TNFAIP3/EGR1/HMGB1 5 GO:0090174 organelle membrane fusion 5/308 110/18722 0.035317993971767 0.136799078980816 SNCA/SAMD9/VAMP2/RAB8A/ANXA1 5 GO:0002695 negative regulation of leukocyte activation 7/308 187/18722 0.0354150320227202 0.137036100630424 HLA-DRB1/CEBPB/TNFAIP3/HLA-F/HMGB1/LAPTM5/ANXA1 7 GO:0021762 substantia nigra development 3/308 44/18722 0.0355707634908284 0.137222027069058 YWHAH/BASP1/CALM1 3 GO:0042269 regulation of natural killer cell mediated cytotoxicity 3/308 44/18722 0.0355707634908284 0.137222027069058 HLA-B/HLA-A/HLA-F 3 GO:0150076 neuroinflammatory response 3/308 44/18722 0.0355707634908284 0.137222027069058 CCL3/NUPR1/IL1B 3 GO:0009306 protein secretion 11/308 359/18722 0.0360518602662967 0.138937763909327 HLA-DRB1/MPC2/ENSA/IL1B/SRI/RAB8A/EGFR/RSAD2/RAC1/APOE/ANXA1 11 GO:0033157 regulation of intracellular protein transport 8/308 229/18722 0.0361907347602613 0.139332506534219 BNIP3L/ANP32B/IL1B/VAMP2/HSP90AB1/IFI27/OAZ1/GCC2 8 GO:0031100 animal organ regeneration 4/308 76/18722 0.0366159106070518 0.140686056533426 SRSF5/CEBPB/EGFR/RPS15 4 GO:0071426 ribonucleoprotein complex export from nucleus 4/308 76/18722 0.0366159106070518 0.140686056533426 SSB/SRSF3/NPM1/RPS15 4 GO:0035592 establishment of protein localization to extracellular region 11/308 360/18722 0.0366671681502719 0.140741550038644 HLA-DRB1/MPC2/ENSA/IL1B/SRI/RAB8A/EGFR/RSAD2/RAC1/APOE/ANXA1 11 GO:0010506 regulation of autophagy 10/308 317/18722 0.0376285237329864 0.144124676542209 SNCA/BNIP3L/CASP1/NUPR1/TRIM22/RAB8A/EEF1A1/BID/MCL1/HMGB1 10 GO:0010824 regulation of centrosome duplication 3/308 45/18722 0.03766166671872 0.144124676542209 CHMP1B/CHMP5/NPM1 3 GO:0035305 negative regulation of dephosphorylation 3/308 45/18722 0.03766166671872 0.144124676542209 PPP1R15A/SWAP70/ENSA 3 GO:0071166 ribonucleoprotein complex localization 4/308 77/18722 0.0381408810873852 0.145090930181609 SSB/SRSF3/NPM1/RPS15 4 GO:0002281 macrophage activation involved in immune response 2/308 19/18722 0.0383695868201952 0.145090930181609 NMI/HMGB1 2 GO:0002523 leukocyte migration involved in inflammatory response 2/308 19/18722 0.0383695868201952 0.145090930181609 S100A8/S100A9 2 GO:0010544 negative regulation of platelet activation 2/308 19/18722 0.0383695868201952 0.145090930181609 APOE/CD9 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/308 19/18722 0.0383695868201952 0.145090930181609 CXCL8/APOBEC3A 2 GO:0045947 negative regulation of translational initiation 2/308 19/18722 0.0383695868201952 0.145090930181609 PAIP2/EIF3E 2 GO:0048245 eosinophil chemotaxis 2/308 19/18722 0.0383695868201952 0.145090930181609 CCL3/CCL4 2 GO:0051444 negative regulation of ubiquitin-protein transferase activity 2/308 19/18722 0.0383695868201952 0.145090930181609 RPL37/RPS15 2 GO:0072074 kidney mesenchyme development 2/308 19/18722 0.0383695868201952 0.145090930181609 BASP1/STAT1 2 GO:0140131 positive regulation of lymphocyte chemotaxis 2/308 19/18722 0.0383695868201952 0.145090930181609 CCL3/CCL4 2 GO:1903975 regulation of glial cell migration 2/308 19/18722 0.0383695868201952 0.145090930181609 CCL3/GPR183 2 GO:2000269 regulation of fibroblast apoptotic process 2/308 19/18722 0.0383695868201952 0.145090930181609 BID/BTG1 2 GO:0010594 regulation of endothelial cell migration 8/308 232/18722 0.0386041901940111 0.145833813351486 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/ANXA1 8 GO:0031497 chromatin assembly 6/308 151/18722 0.0389433010198098 0.146605937276761 HMGB2/ANP32B/SET/NPM1/HMGB1/NAP1L1 6 GO:0071333 cellular response to glucose stimulus 6/308 151/18722 0.0389433010198098 0.146605937276761 HLA-DRB1/MPC2/SRI/SERPINF1/RAC1/LGALS1 6 GO:0031623 receptor internalization 5/308 113/18722 0.0389566450309286 0.146605937276761 SNCA/CXCL8/GRB2/SDCBP/CD9 5 GO:0050821 protein stabilization 7/308 191/18722 0.0389987916819978 0.146605937276761 HSPA1A/UBE2B/PTGES3/HSP90AB1/HSPA1B/NPM1/HSP90AA1 7 GO:1904951 positive regulation of establishment of protein localization 10/308 319/18722 0.0390003238845059 0.146605937276761 HLA-DRB1/MPC2/ANP32B/IL1B/VAMP2/SRI/HSP90AB1/EGFR/RAC1/OAZ1 10 GO:0050767 regulation of neurogenesis 11/308 364/18722 0.0392022039283711 0.14722006445792 B2M/YWHAH/HMGB2/IL1B/CXCR4/BHLHE41/EGFR/SERPINF1/FN1/NAP1L1/HES1 11 GO:0030500 regulation of bone mineralization 4/308 78/18722 0.0397018025978578 0.148803913070206 CCL3/ISG15/FBN2/SRGN 4 GO:0032024 positive regulation of insulin secretion 4/308 78/18722 0.0397018025978578 0.148803913070206 HLA-DRB1/MPC2/SRI/RAC1 4 GO:0031057 negative regulation of histone modification 3/308 46/18722 0.0398140881581314 0.148932738775476 SNCA/UBE2B/SET 3 GO:0033047 regulation of mitotic sister chromatid segregation 3/308 46/18722 0.0398140881581314 0.148932738775476 DUSP1/IK/HNRNPU 3 GO:0007041 lysosomal transport 5/308 114/18722 0.0402184622298243 0.15029831975036 CHMP5/HSPA1A/RHOB/GCC2/LAPTM5 5 GO:0071331 cellular response to hexose stimulus 6/308 153/18722 0.0410918107168032 0.153041909446016 HLA-DRB1/MPC2/SRI/SERPINF1/RAC1/LGALS1 6 GO:0032272 negative regulation of protein polymerization 4/308 79/18722 0.0412986912763683 0.153041909446016 SNCA/TMSB4X/VDAC2/MYADM 4 GO:0051279 regulation of release of sequestered calcium ion into cytosol 4/308 79/18722 0.0412986912763683 0.153041909446016 SNCA/SRI/CALM1/CXCL10 4 GO:0030278 regulation of ossification 5/308 115/18722 0.0415048699704538 0.153041909446016 CCL3/ISG15/FBN2/SRGN/PTGER4 5 GO:0043279 response to alkaloid 5/308 115/18722 0.0415048699704538 0.153041909446016 FOSB/SNCA/SRSF9/CXCR4/HSP90AB1 5 GO:0051209 release of sequestered calcium ion into cytosol 5/308 115/18722 0.0415048699704538 0.153041909446016 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0071675 regulation of mononuclear cell migration 5/308 115/18722 0.0415048699704538 0.153041909446016 CCL3/DUSP1/CCL4/HMGB1/CXCL10 5 GO:0043542 endothelial cell migration 9/308 279/18722 0.0419245322681677 0.153041909446016 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/ANXA1/S100P 9 GO:0030072 peptide hormone secretion 8/308 236/18722 0.0419866972556372 0.153041909446016 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RAC1/ANXA1 8 GO:0001774 microglial cell activation 3/308 47/18722 0.0420275976892233 0.153041909446016 CCL3/SNCA/C1QA 3 GO:0097300 programmed necrotic cell death 3/308 47/18722 0.0420275976892233 0.153041909446016 CASP1/NUPR1/ASAH1 3 GO:1903170 negative regulation of calcium ion transmembrane transport 3/308 47/18722 0.0420275976892233 0.153041909446016 SRI/C4orf3/CALM1 3 GO:0002834 regulation of response to tumor cell 2/308 20/18722 0.0421790491720043 0.153041909446016 HLA-DRB1/HMGB1 2 GO:0002837 regulation of immune response to tumor cell 2/308 20/18722 0.0421790491720043 0.153041909446016 HLA-DRB1/HMGB1 2 GO:0009713 catechol-containing compound biosynthetic process 2/308 20/18722 0.0421790491720043 0.153041909446016 SNCA/NR4A2 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/308 20/18722 0.0421790491720043 0.153041909446016 SRI/CALM1 2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 2/308 20/18722 0.0421790491720043 0.153041909446016 DDIT4/CALM1 2 GO:0015669 gas transport 2/308 20/18722 0.0421790491720043 0.153041909446016 HBA2/HBA1 2 GO:0032211 negative regulation of telomere maintenance via telomerase 2/308 20/18722 0.0421790491720043 0.153041909446016 HNRNPA1/HNRNPU 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/308 20/18722 0.0421790491720043 0.153041909446016 CXCL8/APOBEC3A 2 GO:0042423 catecholamine biosynthetic process 2/308 20/18722 0.0421790491720043 0.153041909446016 SNCA/NR4A2 2 GO:0045063 T-helper 1 cell differentiation 2/308 20/18722 0.0421790491720043 0.153041909446016 HMGB1/ANXA1 2 GO:0060231 mesenchymal to epithelial transition 2/308 20/18722 0.0421790491720043 0.153041909446016 BASP1/STAT1 2 GO:0060252 positive regulation of glial cell proliferation 2/308 20/18722 0.0421790491720043 0.153041909446016 IL1B/EGFR 2 GO:0071243 cellular response to arsenic-containing substance 2/308 20/18722 0.0421790491720043 0.153041909446016 ATF3/HNRNPA1 2 GO:2000678 negative regulation of transcription regulatory region DNA binding 2/308 20/18722 0.0421790491720043 0.153041909446016 TMSB4X/SRI 2 GO:2000757 negative regulation of peptidyl-lysine acetylation 2/308 20/18722 0.0421790491720043 0.153041909446016 SNCA/SET 2 GO:0008360 regulation of cell shape 6/308 154/18722 0.0421936103991892 0.153041909446016 CCL3/RHOB/RAC1/FN1/ALDOA/ANXA1 6 GO:0016052 carbohydrate catabolic process 6/308 154/18722 0.0421936103991892 0.153041909446016 NUPR1/HK2/DDIT4/LDHA/HMGB1/ALDOA 6 GO:0030856 regulation of epithelial cell differentiation 6/308 154/18722 0.0421936103991892 0.153041909446016 CEBPB/ZFP36/IL1B/STAT1/BTG1/HES1 6 GO:0071326 cellular response to monosaccharide stimulus 6/308 154/18722 0.0421936103991892 0.153041909446016 HLA-DRB1/MPC2/SRI/SERPINF1/RAC1/LGALS1 6 GO:0030073 insulin secretion 7/308 195/18722 0.0428123890939698 0.154858379438663 HLA-DRB1/MPC2/ENSA/IL1B/SRI/RAC1/ANXA1 7 GO:0021782 glial cell development 5/308 116/18722 0.0428159317464469 0.154858379438663 EGFR/S100A8/CD9/S100A9/C1QA 5 GO:0051283 negative regulation of sequestering of calcium ion 5/308 116/18722 0.0428159317464469 0.154858379438663 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0051303 establishment of chromosome localization 4/308 80/18722 0.0429315476726882 0.155129779539402 CHMP1B/CHMP5/UBE2B/HNRNPU 4 GO:0007519 skeletal muscle tissue development 6/308 155/18722 0.0433138616077935 0.156363449411326 FOS/SAP30/NUPR1/ATF3/EGR1/DDX5 6 GO:0022613 ribonucleoprotein complex biogenesis 13/308 463/18722 0.0435716602755681 0.157145714371224 SRSF5/RPS28/SRSF9/SBDS/PTGES3/HSP90AB1/RPS27/NPM1/RPL3/EIF3E/RPS27L/HSP90AA1/RPS15 13 GO:0090276 regulation of peptide hormone secretion 7/308 196/18722 0.0438021707078477 0.157828179657023 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RAC1 7 GO:0051225 spindle assembly 5/308 117/18722 0.0441517038992357 0.158788301041183 CHMP1B/CHMP5/HSPA1A/HSPA1B/HNRNPU 5 GO:0072676 lymphocyte migration 5/308 117/18722 0.0441517038992357 0.158788301041183 CCL3/CCL3L3/CCL4/GPR183/CXCL10 5 GO:0002715 regulation of natural killer cell mediated immunity 3/308 48/18722 0.0443017276836299 0.159028643131002 HLA-B/HLA-A/HLA-F 3 GO:0035036 sperm-egg recognition 3/308 48/18722 0.0443017276836299 0.159028643131002 VDAC2/ALDOA/CD9 3 GO:1903532 positive regulation of secretion by cell 9/308 282/18722 0.0443438599393273 0.159030559613554 HLA-DRB1/SNCA/MPC2/IL1B/HLA-F/SRI/EGFR/SDCBP/RAC1 9 GO:0000422 autophagy of mitochondrion 4/308 81/18722 0.0446003569998027 0.159352490476865 BNIP3L/GABARAPL2/HK2/MAP1LC3B 4 GO:0021954 central nervous system neuron development 4/308 81/18722 0.0446003569998027 0.159352490476865 HSP90AB1/NR4A2/HSP90AA1/UBB 4 GO:0060968 regulation of gene silencing 4/308 81/18722 0.0446003569998027 0.159352490476865 ZFP36/EGFR/NEAT1/DDX5 4 GO:0061726 mitochondrion disassembly 4/308 81/18722 0.0446003569998027 0.159352490476865 BNIP3L/GABARAPL2/HK2/MAP1LC3B 4 GO:0051282 regulation of sequestering of calcium ion 5/308 118/18722 0.0455122356465868 0.162458708568535 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0007034 vacuolar transport 6/308 157/18722 0.0456099605667893 0.162655670939212 CHMP1B/CHMP5/HSPA1A/RHOB/GCC2/LAPTM5 6 GO:0007179 transforming growth factor beta receptor signaling pathway 7/308 198/18722 0.0458257880388199 0.162665825163309 JUN/FOS/FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1 7 GO:0031099 regeneration 7/308 198/18722 0.0458257880388199 0.162665825163309 KLF4/SRSF5/CEBPB/EGFR/CD9/RPS15/ANXA1 7 GO:0030502 negative regulation of bone mineralization 2/308 21/18722 0.0461233990261644 0.162665825163309 CCL3/SRGN 2 GO:0044766 multi-organism transport 2/308 21/18722 0.0461233990261644 0.162665825163309 IFIT1/BST2 2 GO:0045655 regulation of monocyte differentiation 2/308 21/18722 0.0461233990261644 0.162665825163309 JUN/HLA-DRB1 2 GO:0071498 cellular response to fluid shear stress 2/308 21/18722 0.0461233990261644 0.162665825163309 KLF2/KLF4 2 GO:0072111 cell proliferation involved in kidney development 2/308 21/18722 0.0461233990261644 0.162665825163309 EGR1/STAT1 2 GO:0072170 metanephric tubule development 2/308 21/18722 0.0461233990261644 0.162665825163309 STAT1/HES1 2 GO:0072243 metanephric nephron epithelium development 2/308 21/18722 0.0461233990261644 0.162665825163309 STAT1/HES1 2 GO:0090026 positive regulation of monocyte chemotaxis 2/308 21/18722 0.0461233990261644 0.162665825163309 HMGB1/CXCL10 2 GO:0150146 cell junction disassembly 2/308 21/18722 0.0461233990261644 0.162665825163309 C1QC/C1QA 2 GO:1902579 multi-organism localization 2/308 21/18722 0.0461233990261644 0.162665825163309 IFIT1/BST2 2 GO:0002312 B cell activation involved in immune response 4/308 82/18722 0.0463050893908618 0.162821307841292 IRF8/SWAP70/GPR183/LGALS1 4 GO:0050000 chromosome localization 4/308 82/18722 0.0463050893908618 0.162821307841292 CHMP1B/CHMP5/UBE2B/HNRNPU 4 GO:0018198 peptidyl-cysteine modification 3/308 49/18722 0.0466359749113823 0.162821307841292 PRDX3/S100A8/S100A9 3 GO:0030225 macrophage differentiation 3/308 49/18722 0.0466359749113823 0.162821307841292 HLA-DRB1/TRIB1/C1QC 3 GO:0042304 regulation of fatty acid biosynthetic process 3/308 49/18722 0.0466359749113823 0.162821307841292 IL1B/ANXA1/APOC1 3 GO:0043330 response to exogenous dsRNA 3/308 49/18722 0.0466359749113823 0.162821307841292 NFKBIA/IFIT1/IFIH1 3 GO:0046605 regulation of centrosome cycle 3/308 49/18722 0.0466359749113823 0.162821307841292 CHMP1B/CHMP5/NPM1 3 GO:0048168 regulation of neuronal synaptic plasticity 3/308 49/18722 0.0466359749113823 0.162821307841292 SNCA/RAB8A/APOE 3 GO:0070169 positive regulation of biomineral tissue development 3/308 49/18722 0.0466359749113823 0.162821307841292 ISG15/FBN2/CEBPB 3 GO:0072666 establishment of protein localization to vacuole 3/308 49/18722 0.0466359749113823 0.162821307841292 TNFAIP3/GCC2/LAPTM5 3 GO:1901799 negative regulation of proteasomal protein catabolic process 3/308 49/18722 0.0466359749113823 0.162821307841292 GABARAPL2/HSP90AB1/SDCBP 3 GO:0030282 bone mineralization 5/308 119/18722 0.0468975691147602 0.163585225114716 CCL3/ISG15/FBN2/SRGN/SBDS 5 GO:0042060 wound healing 12/308 422/18722 0.0473422536975959 0.16498581211113 FBLN1/PLSCR1/TNFAIP3/CXCR4/EGFR/DSP/S100A8/APOE/HMGB1/FN1/CD9/ANXA1 12 GO:0071214 cellular response to abiotic stimulus 10/308 331/18722 0.0479591204235551 0.166526483877113 RHOB/CASP1/IL1B/EGR1/GRB2/PTGER4/EGFR/RAC1/NPM1/ADIRF 10 GO:0104004 cellular response to environmental stimulus 10/308 331/18722 0.0479591204235551 0.166526483877113 RHOB/CASP1/IL1B/EGR1/GRB2/PTGER4/EGFR/RAC1/NPM1/ADIRF 10 GO:0032200 telomere organization 6/308 159/18722 0.0479805531501554 0.166526483877113 PTGES3/HSP90AB1/HNRNPA1/HNRNPU/PKIB/HSP90AA1 6 GO:1903169 regulation of calcium ion transmembrane transport 6/308 159/18722 0.0479805531501554 0.166526483877113 SNCA/SRI/C4orf3/CALM1/VMP1/CXCL10 6 GO:0046785 microtubule polymerization 4/308 83/18722 0.0480457001612491 0.166526483877113 SNCA/HSPA1A/HSPA1B/RAC1 4 GO:0051899 membrane depolarization 4/308 83/18722 0.0480457001612491 0.166526483877113 JUN/YWHAH/CASP1/IFI6 4 GO:0032411 positive regulation of transporter activity 5/308 120/18722 0.0483077393741812 0.167283050387223 TMSB4X/GLRX/SGK1/CALM1/VMP1 5 GO:0006403 RNA localization 7/308 201/18722 0.0489721106217543 0.169170518523384 MX2/ZFP36/SSB/SRSF3/HNRNPA1/NPM1/HNRNPU 7 GO:0007080 mitotic metaphase plate congression 3/308 50/18722 0.0490298023865837 0.169170518523384 CHMP1B/CHMP5/HNRNPU 3 GO:0110151 positive regulation of biomineralization 3/308 50/18722 0.0490298023865837 0.169170518523384 ISG15/FBN2/CEBPB 3 GO:2000677 regulation of transcription regulatory region DNA binding 3/308 50/18722 0.0490298023865837 0.169170518523384 KLF4/TMSB4X/SRI 3 GO:1904019 epithelial cell apoptotic process 5/308 121/18722 0.0497427744785161 0.170581236778034 ZFP36/NUPR1/TNFAIP3/BID/KRT8 5 GO:0006405 RNA export from nucleus 4/308 84/18722 0.0498221300752932 0.170581236778034 SSB/SRSF3/HNRNPA1/NPM1 4 GO:0045445 myoblast differentiation 4/308 84/18722 0.0498221300752932 0.170581236778034 BTG1/DDX5/LGALS1/CXCL10 4 GO:1900542 regulation of purine nucleotide metabolic process 4/308 84/18722 0.0498221300752932 0.170581236778034 SNCA/TMSB4X/NUPR1/DDIT4 4 GO:0009913 epidermal cell differentiation 7/308 202/18722 0.0500506440422732 0.170581236778034 KLF4/ZFP36/DSP/HES1/ASAH1/ANXA1/TXNIP 7 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 2/308 22/18722 0.0501971988949223 0.170581236778034 HMGB1/ANXA1 2 GO:0044346 fibroblast apoptotic process 2/308 22/18722 0.0501971988949223 0.170581236778034 BID/BTG1 2 GO:0045624 positive regulation of T-helper cell differentiation 2/308 22/18722 0.0501971988949223 0.170581236778034 NFKBIZ/ANXA1 2 GO:0048026 positive regulation of mRNA splicing, via spliceosome 2/308 22/18722 0.0501971988949223 0.170581236778034 NCL/CIRBP 2 GO:0048169 regulation of long-term neuronal synaptic plasticity 2/308 22/18722 0.0501971988949223 0.170581236778034 SNCA/RAB8A 2 GO:0050860 negative regulation of T cell receptor signaling pathway 2/308 22/18722 0.0501971988949223 0.170581236778034 GBP1/LAPTM5 2 GO:0060563 neuroepithelial cell differentiation 2/308 22/18722 0.0501971988949223 0.170581236778034 CEBPB/HES1 2 GO:0061042 vascular wound healing 2/308 22/18722 0.0501971988949223 0.170581236778034 TNFAIP3/CXCR4 2 GO:0072574 hepatocyte proliferation 2/308 22/18722 0.0501971988949223 0.170581236778034 CEBPB/TNFAIP3 2 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 2/308 22/18722 0.0501971988949223 0.170581236778034 CEBPB/TNFAIP3 2 GO:1900120 regulation of receptor binding 2/308 22/18722 0.0501971988949223 0.170581236778034 B2M/PHLDA2 2 GO:1900543 negative regulation of purine nucleotide metabolic process 2/308 22/18722 0.0501971988949223 0.170581236778034 NUPR1/DDIT4 2 GO:0032869 cellular response to insulin stimulus 7/308 203/18722 0.0511441281076144 0.173380461127287 SRSF5/IL1B/VAMP2/GRB2/RAB8A/STAT1/SOCS3 7 GO:0060541 respiratory system development 7/308 203/18722 0.0511441281076144 0.173380461127287 KLF2/PTGES3/BASP1/EGFR/HMGB1/CTSH/HES1 7 GO:0050868 negative regulation of T cell activation 5/308 122/18722 0.0512026955070399 0.173380461127287 HLA-DRB1/CEBPB/HMGB1/LAPTM5/ANXA1 5 GO:0051208 sequestering of calcium ion 5/308 122/18722 0.0512026955070399 0.173380461127287 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0071375 cellular response to peptide hormone stimulus 9/308 290/18722 0.0512476905764673 0.173380461127287 SRSF5/IL1B/VAMP2/GRB2/RAB8A/STAT1/SOCS3/NR4A2/FBN1 9 GO:0050678 regulation of epithelial cell proliferation 11/308 381/18722 0.0513387048459865 0.173534808688069 B2M/HMGB2/ZFP36/NUPR1/TNFAIP3/EGFR/STAT1/SERPINF1/APOE/HMGB1/HES1 11 GO:0014009 glial cell proliferation 3/308 51/18722 0.0514826411534663 0.17371415457167 IL1B/EGFR/HES1 3 GO:0021872 forebrain generation of neurons 3/308 51/18722 0.0514826411534663 0.17371415457167 B2M/UBB/HES1 3 GO:0021953 central nervous system neuron differentiation 6/308 162/18722 0.0516769408545906 0.174216000782275 B2M/HSP90AB1/NR4A2/HSP90AA1/UBB/HES1 6 GO:0032386 regulation of intracellular transport 10/308 337/18722 0.0529195623858596 0.177713090896099 BNIP3L/MX2/ANP32B/IL1B/VAMP2/HSP90AB1/IFI27/SNX3/OAZ1/GCC2 10 GO:0050657 nucleic acid transport 6/308 163/18722 0.0529466938348566 0.177713090896099 MX2/ZFP36/SSB/SRSF3/HNRNPA1/NPM1 6 GO:0050658 RNA transport 6/308 163/18722 0.0529466938348566 0.177713090896099 MX2/ZFP36/SSB/SRSF3/HNRNPA1/NPM1 6 GO:0061025 membrane fusion 6/308 163/18722 0.0529466938348566 0.177713090896099 SNCA/SAMD9/VAMP2/RAB8A/CD9/ANXA1 6 GO:0071322 cellular response to carbohydrate stimulus 6/308 163/18722 0.0529466938348566 0.177713090896099 HLA-DRB1/MPC2/SRI/SERPINF1/RAC1/LGALS1 6 GO:0010632 regulation of epithelial cell migration 9/308 292/18722 0.0530780578589121 0.17799773262686 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/CTSH/ANXA1 9 GO:0006140 regulation of nucleotide metabolic process 4/308 86/18722 0.0534821392655322 0.178569623067362 SNCA/TMSB4X/NUPR1/DDIT4 4 GO:0015908 fatty acid transport 4/308 86/18722 0.0534821392655322 0.178569623067362 PLIN2/IL1B/APOE/ANXA1 4 GO:0022406 membrane docking 4/308 86/18722 0.0534821392655322 0.178569623067362 RAB8A/SNX3/CALM1/VMP1 4 GO:0060761 negative regulation of response to cytokine stimulus 4/308 86/18722 0.0534821392655322 0.178569623067362 KLF4/ISG15/OAS1/OAS3 4 GO:2001251 negative regulation of chromosome organization 4/308 86/18722 0.0534821392655322 0.178569623067362 DUSP1/HNRNPA1/IK/HNRNPU 4 GO:0043277 apoptotic cell clearance 3/308 52/18722 0.0539938920144228 0.178653495391892 RAC1/HMGB1/ANXA1 3 GO:0009132 nucleoside diphosphate metabolic process 5/308 124/18722 0.0541972450581735 0.178653495391892 NUPR1/HK2/DDIT4/LDHA/ALDOA 5 GO:0046883 regulation of hormone secretion 8/308 249/18722 0.0543156874189387 0.178653495391892 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RAC1/ANXA1 8 GO:0001919 regulation of receptor recycling 2/308 23/18722 0.0543951526644423 0.178653495391892 SNCA/CHMP5 2 GO:0002082 regulation of oxidative phosphorylation 2/308 23/18722 0.0543951526644423 0.178653495391892 SNCA/NUPR1 2 GO:0006622 protein targeting to lysosome 2/308 23/18722 0.0543951526644423 0.178653495391892 GCC2/LAPTM5 2 GO:0006929 substrate-dependent cell migration 2/308 23/18722 0.0543951526644423 0.178653495391892 SDCBP/FN1 2 GO:0019430 removal of superoxide radicals 2/308 23/18722 0.0543951526644423 0.178653495391892 SOD2/PRDX1 2 GO:0031338 regulation of vesicle fusion 2/308 23/18722 0.0543951526644423 0.178653495391892 SNCA/ANXA1 2 GO:0035994 response to muscle stretch 2/308 23/18722 0.0543951526644423 0.178653495391892 NFKBIA/FOS 2 GO:0045723 positive regulation of fatty acid biosynthetic process 2/308 23/18722 0.0543951526644423 0.178653495391892 IL1B/ANXA1 2 GO:0045980 negative regulation of nucleotide metabolic process 2/308 23/18722 0.0543951526644423 0.178653495391892 NUPR1/DDIT4 2 GO:0051882 mitochondrial depolarization 2/308 23/18722 0.0543951526644423 0.178653495391892 CASP1/IFI6 2 GO:0060353 regulation of cell adhesion molecule production 2/308 23/18722 0.0543951526644423 0.178653495391892 CXCL8/IL1B 2 GO:0072576 liver morphogenesis 2/308 23/18722 0.0543951526644423 0.178653495391892 CEBPB/TNFAIP3 2 GO:0090335 regulation of brown fat cell differentiation 2/308 23/18722 0.0543951526644423 0.178653495391892 METRNL/HNRNPU 2 GO:1902410 mitotic cytokinetic process 2/308 23/18722 0.0543951526644423 0.178653495391892 CHMP1B/CHMP5 2 GO:1904666 regulation of ubiquitin protein ligase activity 2/308 23/18722 0.0543951526644423 0.178653495391892 RPL37/RPS15 2 GO:2000737 negative regulation of stem cell differentiation 2/308 23/18722 0.0543951526644423 0.178653495391892 HNRNPU/HES1 2 GO:0045786 negative regulation of cell cycle 11/308 385/18722 0.0545258626130732 0.178929075338866 KLF4/DUSP1/RHOB/NUPR1/TNFAIP3/SYF2/EGFR/IK/BTG1/NPM1/RPS27L 11 GO:0045860 positive regulation of protein kinase activity 11/308 386/18722 0.0553428899224434 0.181373110811122 SNCA/NCF1/IL1B/EGR1/HSP90AB1/RPLP1/EGFR/NPM1/HMGB1/HSP90AA1/CALM1 11 GO:1903578 regulation of ATP metabolic process 4/308 87/18722 0.0553655297715354 0.181373110811122 SNCA/TMSB4X/NUPR1/DDIT4 4 GO:0050796 regulation of insulin secretion 6/308 165/18722 0.0555428253456456 0.181798134671578 HLA-DRB1/MPC2/ENSA/IL1B/SRI/RAC1 6 GO:0002707 negative regulation of lymphocyte mediated immunity 3/308 53/18722 0.0565629272015637 0.184347886352581 HLA-B/HLA-A/HLA-F 3 GO:0008347 glial cell migration 3/308 53/18722 0.0565629272015637 0.184347886352581 CCL3/GPR183/CD9 3 GO:0016925 protein sumoylation 3/308 53/18722 0.0565629272015637 0.184347886352581 IFIH1/EGR1/SUMO2 3 GO:0032210 regulation of telomere maintenance via telomerase 3/308 53/18722 0.0565629272015637 0.184347886352581 HNRNPA1/HNRNPU/PKIB 3 GO:0045806 negative regulation of endocytosis 3/308 53/18722 0.0565629272015637 0.184347886352581 SDCBP/RAC1/APOC1 3 GO:0030307 positive regulation of cell growth 6/308 166/18722 0.0568692537507337 0.185030771990685 CXCR4/EGFR/SDCBP/S100A8/FN1/S100A9 6 GO:0051236 establishment of RNA localization 6/308 166/18722 0.0568692537507337 0.185030771990685 MX2/ZFP36/SSB/SRSF3/HNRNPA1/NPM1 6 GO:0031110 regulation of microtubule polymerization or depolymerization 4/308 88/18722 0.057284362439711 0.186222889121612 SNCA/HSPA1A/HSPA1B/RAC1 4 GO:0048732 gland development 12/308 436/18722 0.0577561285585763 0.187597008903515 SRSF5/CEBPB/LY6E/TNFAIP3/HK2/OAS2/EGFR/MAFB/SERPINF1/RPS15/HES1/ANXA1 12 GO:0034728 nucleosome organization 6/308 167/18722 0.0582146174581331 0.188925706742311 HMGB2/ANP32E/ANP32B/SET/NPM1/NAP1L1 6 GO:0050673 epithelial cell proliferation 12/308 437/18722 0.0585542968564015 0.189414656225749 B2M/CEBPB/HMGB2/ZFP36/NUPR1/TNFAIP3/EGFR/STAT1/SERPINF1/APOE/HMGB1/HES1 12 GO:0035458 cellular response to interferon-beta 2/308 24/18722 0.058712102439841 0.189414656225749 OAS1/STAT1 2 GO:0045649 regulation of macrophage differentiation 2/308 24/18722 0.058712102439841 0.189414656225749 TRIB1/C1QC 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/308 24/18722 0.058712102439841 0.189414656225749 APOE/CALM1 2 GO:0051156 glucose 6-phosphate metabolic process 2/308 24/18722 0.058712102439841 0.189414656225749 HK2/TKT 2 GO:0090023 positive regulation of neutrophil chemotaxis 2/308 24/18722 0.058712102439841 0.189414656225749 CXCL8/RAC1 2 GO:1901984 negative regulation of protein acetylation 2/308 24/18722 0.058712102439841 0.189414656225749 SNCA/SET 2 GO:0031647 regulation of protein stability 9/308 298/18722 0.0588238724890299 0.189455488227095 SNCA/HSPA1A/UBE2B/PTGES3/HSP90AB1/HSPA1B/NPM1/CTSH/HSP90AA1 9 GO:0048511 rhythmic process 9/308 298/18722 0.0588238724890299 0.189455488227095 JUND/JUN/EGR1/CREM/BHLHE41/EGFR/SERPINF1/HNRNPU/DDX5 9 GO:0051224 negative regulation of protein transport 5/308 127/18722 0.0588758450734793 0.189463262387131 IL1B/RSAD2/SNX3/APOE/ANXA1 5 GO:0001706 endoderm formation 3/308 54/18722 0.0591890919933207 0.190151175370139 DUSP1/DUSP2/FN1 3 GO:0035065 regulation of histone acetylation 3/308 54/18722 0.0591890919933207 0.190151175370139 SNCA/IL1B/SET 3 GO:0072503 cellular divalent inorganic cation homeostasis 13/308 486/18722 0.0594846975284241 0.190922260229151 CCL3/SNCA/SWAP70/CXCR4/SRI/PTGER4/HERPUD1/S100A8/APOE/HMGB1/CALM1/S100A9/CXCL10 13 GO:1902806 regulation of cell cycle G1/S phase transition 6/308 168/18722 0.0595789318476005 0.190922260229151 KLF4/BID/EGFR/PSME2/RPS27L/ANXA1 6 GO:2000241 regulation of reproductive process 6/308 168/18722 0.0595789318476005 0.190922260229151 DUSP1/PHLDA2/UBE2B/NUPR1/SERPINF1/DEFB1 6 GO:1901990 regulation of mitotic cell cycle phase transition 9/308 299/18722 0.0598189440312637 0.191530840059901 KLF4/DUSP1/SYF2/BID/EGFR/IK/PSME2/RPS27L/ANXA1 9 GO:0030100 regulation of endocytosis 7/308 211/18722 0.060434419665346 0.193177915033961 B2M/SNCA/SDCBP/RAC1/APOE/CALM1/APOC1 7 GO:0042180 cellular ketone metabolic process 7/308 211/18722 0.060434419665346 0.193177915033961 SNCA/IL1B/COMT/EGR1/CBR1/ANXA1/APOC1 7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 5/308 128/18722 0.0604851398637587 0.193178521051921 FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1 5 GO:0031214 biomineral tissue development 6/308 169/18722 0.0609622084938289 0.19453966867438 CCL3/ISG15/FBN2/CEBPB/SRGN/SBDS 6 GO:0032392 DNA geometric change 4/308 90/18722 0.061227829950665 0.195061661584494 HMGB2/CHD2/HMGB1/ANXA1 4 GO:0034109 homotypic cell-cell adhesion 4/308 90/18722 0.061227829950665 0.195061661584494 DSP/FN1/CD9/LGALS1 4 GO:0042886 amide transport 9/308 301/18722 0.0618413960869974 0.19678496930046 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/S100A8/RAC1/ANXA1 9 GO:0006414 translational elongation 3/308 55/18722 0.0618717062775709 0.19678496930046 RPLP2/EEF1A1/RPLP1 3 GO:0006334 nucleosome assembly 5/308 129/18722 0.0621192770503783 0.197408143111884 HMGB2/ANP32B/SET/NPM1/NAP1L1 5 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 2/308 25/18722 0.0631430254552279 0.198207416971707 TNFAIP3/TRIB1 2 GO:0033622 integrin activation 2/308 25/18722 0.0631430254552279 0.198207416971707 PTGER4/FN1 2 GO:0035902 response to immobilization stress 2/308 25/18722 0.0631430254552279 0.198207416971707 FOS/SOD2 2 GO:0042832 defense response to protozoan 2/308 25/18722 0.0631430254552279 0.198207416971707 IRF8/GBP4 2 GO:0045109 intermediate filament organization 2/308 25/18722 0.0631430254552279 0.198207416971707 DSP/DNAJB6 2 GO:0045324 late endosome to vacuole transport 2/308 25/18722 0.0631430254552279 0.198207416971707 CHMP1B/CHMP5 2 GO:0048143 astrocyte activation 2/308 25/18722 0.0631430254552279 0.198207416971707 EGFR/C1QA 2 GO:0050995 negative regulation of lipid catabolic process 2/308 25/18722 0.0631430254552279 0.198207416971707 IL1B/APOC1 2 GO:0071450 cellular response to oxygen radical 2/308 25/18722 0.0631430254552279 0.198207416971707 SOD2/PRDX1 2 GO:0071451 cellular response to superoxide 2/308 25/18722 0.0631430254552279 0.198207416971707 SOD2/PRDX1 2 GO:0072012 glomerulus vasculature development 2/308 25/18722 0.0631430254552279 0.198207416971707 EGR1/HES1 2 GO:0072207 metanephric epithelium development 2/308 25/18722 0.0631430254552279 0.198207416971707 STAT1/HES1 2 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 2/308 25/18722 0.0631430254552279 0.198207416971707 SRI/CALM1 2 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/308 25/18722 0.0631430254552279 0.198207416971707 EGFR/DDX5 2 GO:0002275 myeloid cell activation involved in immune response 4/308 91/18722 0.0632521707312275 0.198207416971707 CCL3/VAMP2/NMI/HMGB1 4 GO:0051983 regulation of chromosome segregation 4/308 91/18722 0.0632521707312275 0.198207416971707 PLSCR1/DUSP1/IK/HNRNPU 4 GO:0060191 regulation of lipase activity 4/308 91/18722 0.0632521707312275 0.198207416971707 SNCA/EGFR/ANXA1/APOC1 4 GO:0051960 regulation of nervous system development 12/308 443/18722 0.0634984242616656 0.198816114621087 B2M/YWHAH/HMGB2/IL1B/CXCR4/TYMP/BHLHE41/EGFR/SERPINF1/FN1/NAP1L1/HES1 12 GO:0043467 regulation of generation of precursor metabolites and energy 5/308 130/18722 0.0637782238021588 0.199388911678656 SNCA/PHLDA2/NUPR1/DDIT4/HMGB1 5 GO:0110148 biomineralization 6/308 171/18722 0.0637856759045243 0.199388911678656 CCL3/ISG15/FBN2/CEBPB/SRGN/SBDS 6 GO:0042593 glucose homeostasis 8/308 258/18722 0.0640816679740149 0.200150503810996 HLA-DRB1/MPC2/HK2/OAS1/SRI/SERPINF1/RAC1/LGALS1 8 GO:0043470 regulation of carbohydrate catabolic process 3/308 56/18722 0.06461006606273 0.201471682347322 NUPR1/DDIT4/HMGB1 3 GO:0048255 mRNA stabilization 3/308 56/18722 0.06461006606273 0.201471682347322 ZFP36/CIRBP/HNRNPU 3 GO:0042770 signal transduction in response to DNA damage 6/308 172/18722 0.0652258709096252 0.203073617353083 SYF2/GRB2/BID/NPM1/DDX5/RPS27L 6 GO:0033500 carbohydrate homeostasis 8/308 259/18722 0.0652300293250292 0.203073617353083 HLA-DRB1/MPC2/HK2/OAS1/SRI/SERPINF1/RAC1/LGALS1 8 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 5/308 131/18722 0.0654619408252813 0.20362978012616 FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1 5 GO:0090150 establishment of protein localization to membrane 8/308 260/18722 0.0663911118911878 0.206352212000009 NCF1/VAMP2/RAB8A/BID/EGFR/SDCBP/HSP90AA1/CALM1 8 GO:0006887 exocytosis 10/308 352/18722 0.0667750983910103 0.207001782155609 CCL3/SNCA/TNFAIP2/VAMP2/RALA/HLA-F/RAB8A/SDCBP/CALM1/ANXA1 10 GO:0045667 regulation of osteoblast differentiation 5/308 132/18722 0.0671703824327358 0.207001782155609 JUND/FBN2/CEBPB/DDX5/IFITM1 5 GO:0006611 protein export from nucleus 3/308 57/18722 0.0674034449382228 0.207001782155609 ANP32B/IL1B/IFI27 3 GO:0010883 regulation of lipid storage 3/308 57/18722 0.0674034449382228 0.207001782155609 NFKBIA/PLIN2/MEST 3 GO:0051289 protein homotetramerization 3/308 57/18722 0.0674034449382228 0.207001782155609 B2M/SOD2/ALDOA 3 GO:0061005 cell differentiation involved in kidney development 3/308 57/18722 0.0674034449382228 0.207001782155609 BASP1/STAT1/HES1 3 GO:0019217 regulation of fatty acid metabolic process 4/308 93/18722 0.0674052384968634 0.207001782155609 SNCA/IL1B/ANXA1/APOC1 4 GO:0097306 cellular response to alcohol 4/308 93/18722 0.0674052384968634 0.207001782155609 KLF2/KLF4/SOD2/PTGER4 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 4/308 93/18722 0.0674052384968634 0.207001782155609 SRI/C4orf3/CALM1/VMP1 4 GO:0001562 response to protozoan 2/308 26/18722 0.0676830310474787 0.207001782155609 IRF8/GBP4 2 GO:0006706 steroid catabolic process 2/308 26/18722 0.0676830310474787 0.207001782155609 YWHAH/APOE 2 GO:0010875 positive regulation of cholesterol efflux 2/308 26/18722 0.0676830310474787 0.207001782155609 NFKBIA/APOE 2 GO:0046639 negative regulation of alpha-beta T cell differentiation 2/308 26/18722 0.0676830310474787 0.207001782155609 HMGB1/ANXA1 2 GO:0046755 viral budding 2/308 26/18722 0.0676830310474787 0.207001782155609 CHMP1B/CHMP5 2 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/308 26/18722 0.0676830310474787 0.207001782155609 SRI/CALM1 2 GO:0060352 cell adhesion molecule production 2/308 26/18722 0.0676830310474787 0.207001782155609 CXCL8/IL1B 2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/308 26/18722 0.0676830310474787 0.207001782155609 EGFR/DDX5 2 GO:0072273 metanephric nephron morphogenesis 2/308 26/18722 0.0676830310474787 0.207001782155609 STAT1/HES1 2 GO:0097066 response to thyroid hormone 2/308 26/18722 0.0676830310474787 0.207001782155609 LMO2/CTSH 2 GO:0099637 neurotransmitter receptor transport 2/308 26/18722 0.0676830310474787 0.207001782155609 VAMP2/RAB8A 2 GO:0008154 actin polymerization or depolymerization 7/308 217/18722 0.0680403100394277 0.207822085705334 TMSB4X/SWAP70/GRB2/RAC1/MYADM/ARPC3/IQGAP2 7 GO:0007584 response to nutrient 6/308 174/18722 0.0681631659868464 0.207822085705334 ENSA/SOD2/EGFR/STAT1/LDHA/CXCL10 6 GO:0045619 regulation of lymphocyte differentiation 6/308 174/18722 0.0681631659868464 0.207822085705334 HLA-DRB1/HLA-DRA/CD83/NFKBIZ/HMGB1/ANXA1 6 GO:0001666 response to hypoxia 9/308 307/18722 0.0681686883270964 0.207822085705334 BNIP3L/CASP1/HK2/SOD2/DDIT4/EGR1/CXCR4/LDHA/NR4A2 9 GO:0010595 positive regulation of endothelial cell migration 5/308 133/18722 0.0689034966159191 0.209727760798295 TMSB4X/RHOB/RAC1/HMGB1/ANXA1 5 GO:0046887 positive regulation of hormone secretion 5/308 133/18722 0.0689034966159191 0.209727760798295 HLA-DRB1/MPC2/SRI/EGFR/RAC1 5 GO:0022900 electron transport chain 6/308 175/18722 0.0696602478660127 0.211862472228931 SNCA/NCF1/SDHD/ALDH2/BID/UQCR11 6 GO:0002931 response to ischemia 3/308 58/18722 0.0702510954857042 0.212812946150434 HK2/EGR1/BID 3 GO:0043666 regulation of phosphoprotein phosphatase activity 3/308 58/18722 0.0702510954857042 0.212812946150434 PPP1R15A/HSP90AB1/CALM1 3 GO:0086065 cell communication involved in cardiac conduction 3/308 58/18722 0.0702510954857042 0.212812946150434 SRI/DSP/CALM1 3 GO:2000649 regulation of sodium ion transmembrane transporter activity 3/308 58/18722 0.0702510954857042 0.212812946150434 YWHAH/GLRX/FXYD3 3 GO:2000736 regulation of stem cell differentiation 3/308 58/18722 0.0702510954857042 0.212812946150434 EIF2AK2/HNRNPU/HES1 3 GO:0034764 positive regulation of transmembrane transport 7/308 219/18722 0.0706978186962401 0.213996643607067 SNCA/TMSB4X/GLRX/SRI/CALM1/VMP1/CXCL10 7 GO:0010634 positive regulation of epithelial cell migration 6/308 176/18722 0.0711762676773482 0.215274423520967 TMSB4X/RHOB/RAC1/HMGB1/CTSH/ANXA1 6 GO:0042773 ATP synthesis coupled electron transport 4/308 95/18722 0.0716962453069311 0.21602147535812 SNCA/SDHD/BID/UQCR11 4 GO:0042775 mitochondrial ATP synthesis coupled electron transport 4/308 95/18722 0.0716962453069311 0.21602147535812 SNCA/SDHD/BID/UQCR11 4 GO:0050764 regulation of phagocytosis 4/308 95/18722 0.0716962453069311 0.21602147535812 PLSCR1/IL1B/SNX3/HMGB1 4 GO:0010631 epithelial cell migration 10/308 357/18722 0.0718648965549866 0.21602147535812 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/CTSH/ANXA1/S100P 10 GO:0032956 regulation of actin cytoskeleton organization 10/308 357/18722 0.0718648965549866 0.21602147535812 TMSB4X/RHOB/SWAP70/GRB2/PTGER4/BST2/RAC1/MYADM/ARPC3/IQGAP2 10 GO:0002227 innate immune response in mucosa 2/308 27/18722 0.0723273576924911 0.21602147535812 RPL39/DEFB1 2 GO:0002719 negative regulation of cytokine production involved in immune response 2/308 27/18722 0.0723273576924911 0.21602147535812 HLA-F/BST2 2 GO:0002825 regulation of T-helper 1 type immune response 2/308 27/18722 0.0723273576924911 0.21602147535812 IL1B/ANXA1 2 GO:0007263 nitric oxide mediated signal transduction 2/308 27/18722 0.0723273576924911 0.21602147535812 EGFR/APOE 2 GO:0034143 regulation of toll-like receptor 4 signaling pathway 2/308 27/18722 0.0723273576924911 0.21602147535812 TNFAIP3/HMGB1 2 GO:0034377 plasma lipoprotein particle assembly 2/308 27/18722 0.0723273576924911 0.21602147535812 APOE/APOC1 2 GO:0061437 renal system vasculature development 2/308 27/18722 0.0723273576924911 0.21602147535812 EGR1/HES1 2 GO:0061440 kidney vasculature development 2/308 27/18722 0.0723273576924911 0.21602147535812 EGR1/HES1 2 GO:0071624 positive regulation of granulocyte chemotaxis 2/308 27/18722 0.0723273576924911 0.21602147535812 CXCL8/RAC1 2 GO:0098901 regulation of cardiac muscle cell action potential 2/308 27/18722 0.0723273576924911 0.21602147535812 DSP/CALM1 2 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 2/308 27/18722 0.0723273576924911 0.21602147535812 HNRNPA1/HNRNPU 2 GO:0006333 chromatin assembly or disassembly 6/308 177/18722 0.0727112071063164 0.216660128423576 HMGB2/ANP32B/SET/NPM1/HMGB1/NAP1L1 6 GO:0030324 lung development 6/308 177/18722 0.0727112071063164 0.216660128423576 KLF2/PTGES3/EGFR/HMGB1/CTSH/HES1 6 GO:0043405 regulation of MAP kinase activity 6/308 177/18722 0.0727112071063164 0.216660128423576 DUSP1/IL1B/EGFR/TRIB1/APOE/DNAJA1 6 GO:0090303 positive regulation of wound healing 3/308 59/18722 0.0731522506423754 0.217804559350313 CXCR4/HMGB1/ANXA1 3 GO:0010769 regulation of cell morphogenesis involved in differentiation 4/308 96/18722 0.0738929670372006 0.219838764967485 FBLN1/GBP1/RAC1/MYADM 4 GO:0045727 positive regulation of translation 5/308 136/18722 0.0742502612702558 0.220729975766865 PPP1R15A/CIRBP/NPM1/EIF3E/RPS27L 5 GO:0090132 epithelium migration 10/308 360/18722 0.0750333550404335 0.222884628064939 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/CTSH/ANXA1/S100P 10 GO:0050714 positive regulation of protein secretion 5/308 137/18722 0.0760814218568168 0.225422383344113 HLA-DRB1/MPC2/SRI/EGFR/RAC1 5 GO:0019731 antibacterial humoral response 3/308 60/18722 0.0761061250177029 0.225422383344113 RPL39/HLA-A/DEFB1 3 GO:1903670 regulation of sprouting angiogenesis 3/308 60/18722 0.0761061250177029 0.225422383344113 KLF2/KLF4/HMGB1 3 GO:0010596 negative regulation of endothelial cell migration 4/308 97/18722 0.0761235409095605 0.225422383344113 KLF4/SERPINF1/APOE/HMGB1 4 GO:0000303 response to superoxide 2/308 28/18722 0.0770713701026966 0.226823593458514 SOD2/PRDX1 2 GO:0032801 receptor catabolic process 2/308 28/18722 0.0770713701026966 0.226823593458514 APOE/LAPTM5 2 GO:0034123 positive regulation of toll-like receptor signaling pathway 2/308 28/18722 0.0770713701026966 0.226823593458514 RSAD2/HMGB1 2 GO:0045589 regulation of regulatory T cell differentiation 2/308 28/18722 0.0770713701026966 0.226823593458514 HLA-DRB1/HLA-DRA 2 GO:0071280 cellular response to copper ion 2/308 28/18722 0.0770713701026966 0.226823593458514 SNCA/AOC1 2 GO:0090200 positive regulation of release of cytochrome c from mitochondria 2/308 28/18722 0.0770713701026966 0.226823593458514 BID/TNFSF10 2 GO:1902624 positive regulation of neutrophil migration 2/308 28/18722 0.0770713701026966 0.226823593458514 CXCL8/RAC1 2 GO:1903672 positive regulation of sprouting angiogenesis 2/308 28/18722 0.0770713701026966 0.226823593458514 KLF4/HMGB1 2 GO:0002768 immune response-regulating cell surface receptor signaling pathway 9/308 315/18722 0.0772162125770427 0.227075062063103 HLA-A/HLA-DRB1/PLSCR1/HLA-DPB1/HLA-DQB1/NFKBIZ/GBP1/FCGR1B/LAPTM5 9 GO:0007033 vacuole organization 6/308 180/18722 0.0774293053760741 0.22752669827266 CHMP5/GABARAPL2/NUPR1/MAP1LC3B/LAPTM5/VMP1 6 GO:1904029 regulation of cyclin-dependent protein kinase activity 4/308 98/18722 0.0783877336040082 0.23016613330885 TNFAIP3/HERC5/HSP90AB1/EGFR 4 GO:0010001 glial cell differentiation 7/308 225/18722 0.0790372377558387 0.231226953744725 CXCR4/EGFR/S100A8/CD9/HES1/S100A9/C1QA 7 GO:0050769 positive regulation of neurogenesis 7/308 225/18722 0.0790372377558387 0.231226953744725 IL1B/CXCR4/EGFR/SERPINF1/FN1/NAP1L1/HES1 7 GO:0030323 respiratory tube development 6/308 181/18722 0.0790396675304362 0.231226953744725 KLF2/PTGES3/EGFR/HMGB1/CTSH/HES1 6 GO:0043030 regulation of macrophage activation 3/308 61/18722 0.0791119161648184 0.231226953744725 JUND/CCL3/SNCA 3 GO:1904356 regulation of telomere maintenance via telomere lengthening 3/308 61/18722 0.0791119161648184 0.231226953744725 HNRNPA1/HNRNPU/PKIB 3 GO:2000401 regulation of lymphocyte migration 3/308 61/18722 0.0791119161648184 0.231226953744725 CCL3/CCL4/CXCL10 3 GO:0030216 keratinocyte differentiation 5/308 139/18722 0.0798166157637446 0.233108420217567 ZFP36/DSP/ASAH1/ANXA1/TXNIP 5 GO:0051495 positive regulation of cytoskeleton organization 7/308 226/18722 0.080480577538497 0.234762958792803 HSPA1A/SWAP70/GRB2/HSPA1B/RAC1/ARPC3/IQGAP2 7 GO:0090130 tissue migration 10/308 365/18722 0.080505947940718 0.234762958792803 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/CTSH/ANXA1/S100P 10 GO:0000045 autophagosome assembly 4/308 99/18722 0.0806853015389328 0.234927576377258 GABARAPL2/NUPR1/MAP1LC3B/VMP1 4 GO:0060291 long-term synaptic potentiation 4/308 99/18722 0.0806853015389328 0.234927576377258 SNCA/VAMP2/PAIP2/APOE 4 GO:0000305 response to oxygen radical 2/308 29/18722 0.0819105563846252 0.236722942429084 SOD2/PRDX1 2 GO:0034067 protein localization to Golgi apparatus 2/308 29/18722 0.0819105563846252 0.236722942429084 ARL5A/GCC2 2 GO:0062098 regulation of programmed necrotic cell death 2/308 29/18722 0.0819105563846252 0.236722942429084 NUPR1/ASAH1 2 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/308 29/18722 0.0819105563846252 0.236722942429084 SOD2/MCL1 2 GO:1903902 positive regulation of viral life cycle 2/308 29/18722 0.0819105563846252 0.236722942429084 HLA-DRB1/LGALS1 2 GO:0007204 positive regulation of cytosolic calcium ion concentration 9/308 319/18722 0.0820032808348971 0.236722942429084 CCL3/SNCA/SWAP70/CXCR4/SRI/PTGER4/HMGB1/CALM1/CXCL10 9 GO:0002260 lymphocyte homeostasis 3/308 62/18722 0.0821688058078458 0.236722942429084 TSC22D3/TNFAIP3/TNFSF13B 3 GO:0009116 nucleoside metabolic process 3/308 62/18722 0.0821688058078458 0.236722942429084 TYMP/NT5C3A/APOBEC3A 3 GO:0032835 glomerulus development 3/308 62/18722 0.0821688058078458 0.236722942429084 EGR1/BASP1/HES1 3 GO:0046173 polyol biosynthetic process 3/308 62/18722 0.0821688058078458 0.236722942429084 SNCA/ISYNA1/ASAH1 3 GO:0046824 positive regulation of nucleocytoplasmic transport 3/308 62/18722 0.0821688058078458 0.236722942429084 ANP32B/IL1B/HSP90AB1 3 GO:0048488 synaptic vesicle endocytosis 3/308 62/18722 0.0821688058078458 0.236722942429084 SNCA/VAMP2/CALM1 3 GO:0070265 necrotic cell death 3/308 62/18722 0.0821688058078458 0.236722942429084 CASP1/NUPR1/ASAH1 3 GO:0140238 presynaptic endocytosis 3/308 62/18722 0.0821688058078458 0.236722942429084 SNCA/VAMP2/CALM1 3 GO:0006119 oxidative phosphorylation 5/308 141/18722 0.0836483557200946 0.239900723119221 SNCA/NUPR1/SDHD/BID/UQCR11 5 GO:0030183 B cell differentiation 5/308 141/18722 0.0836483557200946 0.239900723119221 KLF6/IRF8/GPR183/TNFSF13B/LGALS1 5 GO:0032355 response to estradiol 5/308 141/18722 0.0836483557200946 0.239900723119221 DUSP1/BID/EGFR/ANXA1/TXNIP 5 GO:0035296 regulation of tube diameter 5/308 141/18722 0.0836483557200946 0.239900723119221 KLF2/SCPEP1/SOD2/EGFR/APOE 5 GO:0048284 organelle fusion 5/308 141/18722 0.0836483557200946 0.239900723119221 SNCA/SAMD9/VAMP2/RAB8A/ANXA1 5 GO:0097746 blood vessel diameter maintenance 5/308 141/18722 0.0836483557200946 0.239900723119221 KLF2/SCPEP1/SOD2/EGFR/APOE 5 GO:0007051 spindle organization 6/308 184/18722 0.0839832340748865 0.240680587607415 CHMP1B/CHMP5/HSPA1A/SBDS/HSPA1B/HNRNPU 6 GO:1902373 negative regulation of mRNA catabolic process 3/308 63/18722 0.0852759610263718 0.2440194603322 ZFP36/CIRBP/HNRNPU 3 GO:2000756 regulation of peptidyl-lysine acetylation 3/308 63/18722 0.0852759610263718 0.2440194603322 SNCA/IL1B/SET 3 GO:0035150 regulation of tube size 5/308 142/18722 0.0856001775599441 0.244526394975167 KLF2/SCPEP1/SOD2/EGFR/APOE 5 GO:0097553 calcium ion transmembrane import into cytosol 5/308 142/18722 0.0856001775599441 0.244526394975167 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0007369 gastrulation 6/308 185/18722 0.0856684385897892 0.244526394975167 KLF4/DUSP1/DUSP2/SYF2/MYADM/FN1 6 GO:0036293 response to decreased oxygen levels 9/308 322/18722 0.0857089639724625 0.244526394975167 BNIP3L/CASP1/HK2/SOD2/DDIT4/EGR1/CXCR4/LDHA/NR4A2 9 GO:0033674 positive regulation of kinase activity 12/308 467/18722 0.0859897559923267 0.245012050222268 HLA-DRB1/SNCA/NCF1/IL1B/EGR1/HSP90AB1/RPLP1/EGFR/NPM1/HMGB1/HSP90AA1/CALM1 12 GO:0016197 endosomal transport 7/308 230/18722 0.0864060954413565 0.245012050222268 CHMP1B/CHMP5/RAB8A/SNX2/SNX3/GCC2/TINAGL1 7 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/308 30/18722 0.0868405252553422 0.245012050222268 SRI/CALM1 2 GO:0019674 NAD metabolic process 2/308 30/18722 0.0868405252553422 0.245012050222268 HK2/LDHA 2 GO:0034368 protein-lipid complex remodeling 2/308 30/18722 0.0868405252553422 0.245012050222268 APOE/APOC1 2 GO:0034369 plasma lipoprotein particle remodeling 2/308 30/18722 0.0868405252553422 0.245012050222268 APOE/APOC1 2 GO:0036258 multivesicular body assembly 2/308 30/18722 0.0868405252553422 0.245012050222268 CHMP1B/CHMP5 2 GO:0043032 positive regulation of macrophage activation 2/308 30/18722 0.0868405252553422 0.245012050222268 JUND/CCL3 2 GO:0044788 modulation by host of viral process 2/308 30/18722 0.0868405252553422 0.245012050222268 IFI27/APOE 2 GO:0045940 positive regulation of steroid metabolic process 2/308 30/18722 0.0868405252553422 0.245012050222268 APOE/APOC1 2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 2/308 30/18722 0.0868405252553422 0.245012050222268 GBP1/LAPTM5 2 GO:0060218 hematopoietic stem cell differentiation 2/308 30/18722 0.0868405252553422 0.245012050222268 EIF2AK2/CHD2 2 GO:0070168 negative regulation of biomineral tissue development 2/308 30/18722 0.0868405252553422 0.245012050222268 CCL3/SRGN 2 GO:0070498 interleukin-1-mediated signaling pathway 2/308 30/18722 0.0868405252553422 0.245012050222268 IL1B/EGR1 2 GO:0090151 establishment of protein localization to mitochondrial membrane 2/308 30/18722 0.0868405252553422 0.245012050222268 HSP90AA1/CALM1 2 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 6/308 186/18722 0.0873722367894593 0.246330428647568 HLA-DRB1/CASP1/TRIM22/BST2/TNFSF10/LGALS1 6 GO:0034763 negative regulation of transmembrane transport 5/308 143/18722 0.0875758213029839 0.246722450140978 IL1B/SRI/C4orf3/OAZ1/CALM1 5 GO:0010522 regulation of calcium ion transport into cytosol 4/308 102/18722 0.0877756731406868 0.246921558805626 SNCA/SRI/CALM1/CXCL10 4 GO:0062014 negative regulation of small molecule metabolic process 4/308 102/18722 0.0877756731406868 0.246921558805626 NUPR1/DDIT4/APOE/APOC1 4 GO:0110053 regulation of actin filament organization 8/308 277/18722 0.0880836094546127 0.247605616871312 TMSB4X/SWAP70/GRB2/PTGER4/RAC1/MYADM/ARPC3/IQGAP2 8 GO:0008544 epidermis development 9/308 324/18722 0.0882343415797621 0.247847088801933 HLA-DRB1/KLF4/ZFP36/EGFR/DSP/HES1/ASAH1/ANXA1/TXNIP 9 GO:0048857 neural nucleus development 3/308 64/18722 0.0884325353982452 0.247857465416049 YWHAH/BASP1/CALM1 3 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 3/308 64/18722 0.0884325353982452 0.247857465416049 GABARAPL2/HSP90AB1/SDCBP 3 GO:1903409 reactive oxygen species biosynthetic process 3/308 64/18722 0.0884325353982452 0.247857465416049 SNCA/NCF1/SOD2 3 GO:0008064 regulation of actin polymerization or depolymerization 6/308 187/18722 0.0890945750690195 0.249530080944221 TMSB4X/SWAP70/GRB2/MYADM/ARPC3/IQGAP2 6 GO:0010821 regulation of mitochondrion organization 5/308 144/18722 0.0895751706503111 0.250509054422926 HSPA1A/BNIP3L/RALA/BID/TNFSF10 5 GO:0033135 regulation of peptidyl-serine phosphorylation 5/308 144/18722 0.0895751706503111 0.250509054422926 SNCA/DDIT4/HSP90AB1/EGFR/HSP90AA1 5 GO:0014013 regulation of gliogenesis 4/308 103/18722 0.0902041111368599 0.251899427959252 IL1B/CXCR4/EGFR/HES1 4 GO:1905037 autophagosome organization 4/308 103/18722 0.0902041111368599 0.251899427959252 GABARAPL2/NUPR1/MAP1LC3B/VMP1 4 GO:0030832 regulation of actin filament length 6/308 188/18722 0.0908353964583659 0.253003835503864 TMSB4X/SWAP70/GRB2/MYADM/ARPC3/IQGAP2 6 GO:0015909 long-chain fatty acid transport 3/308 65/18722 0.0916376701018642 0.253003835503864 PLIN2/APOE/ANXA1 3 GO:0043489 RNA stabilization 3/308 65/18722 0.0916376701018642 0.253003835503864 ZFP36/CIRBP/HNRNPU 3 GO:0045453 bone resorption 3/308 65/18722 0.0916376701018642 0.253003835503864 TNFAIP3/EGFR/RAC1 3 GO:0048524 positive regulation of viral process 3/308 65/18722 0.0916376701018642 0.253003835503864 HLA-DRB1/IFIT1/LGALS1 3 GO:0051310 metaphase plate congression 3/308 65/18722 0.0916376701018642 0.253003835503864 CHMP1B/CHMP5/HNRNPU 3 GO:0001782 B cell homeostasis 2/308 31/18722 0.0918570033166004 0.253003835503864 TNFAIP3/TNFSF13B 2 GO:0002230 positive regulation of defense response to virus by host 2/308 31/18722 0.0918570033166004 0.253003835503864 STAT1/HSP90AA1 2 GO:0002828 regulation of type 2 immune response 2/308 31/18722 0.0918570033166004 0.253003835503864 RSAD2/ANXA1 2 GO:0030212 hyaluronan metabolic process 2/308 31/18722 0.0918570033166004 0.253003835503864 IL1B/ITIH5 2 GO:0032509 endosome transport via multivesicular body sorting pathway 2/308 31/18722 0.0918570033166004 0.253003835503864 CHMP1B/CHMP5 2 GO:0036257 multivesicular body organization 2/308 31/18722 0.0918570033166004 0.253003835503864 CHMP1B/CHMP5 2 GO:0045066 regulatory T cell differentiation 2/308 31/18722 0.0918570033166004 0.253003835503864 HLA-DRB1/HLA-DRA 2 GO:0060055 angiogenesis involved in wound healing 2/308 31/18722 0.0918570033166004 0.253003835503864 TNFAIP3/CXCR4 2 GO:0065005 protein-lipid complex assembly 2/308 31/18722 0.0918570033166004 0.253003835503864 APOE/APOC1 2 GO:0090183 regulation of kidney development 2/308 31/18722 0.0918570033166004 0.253003835503864 BASP1/STAT1 2 GO:0110150 negative regulation of biomineralization 2/308 31/18722 0.0918570033166004 0.253003835503864 CCL3/SRGN 2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/308 31/18722 0.0918570033166004 0.253003835503864 HMGB2/TNFAIP3 2 GO:2000144 positive regulation of DNA-templated transcription, initiation 2/308 31/18722 0.0918570033166004 0.253003835503864 JUN/SUB1 2 GO:0044772 mitotic cell cycle phase transition 11/308 424/18722 0.0925834912493583 0.254821228975016 KLF4/DUSP1/ENSA/SYF2/BID/EGFR/IK/PSME2/RPS27L/CALM1/ANXA1 11 GO:0010675 regulation of cellular carbohydrate metabolic process 5/308 146/18722 0.0936444944126414 0.257556044704697 SNCA/PHLDA2/NUPR1/DDIT4/HMGB1 5 GO:0006470 protein dephosphorylation 8/308 281/18722 0.0937237493865967 0.257588708774234 PPP1R15A/DUSP1/SWAP70/ENSA/PPP4C/CAMTA1/HSP90AB1/CALM1 8 GO:0045930 negative regulation of mitotic cell cycle 7/308 235/18722 0.0941536037428091 0.258584214876982 KLF4/DUSP1/SYF2/EGFR/IK/BTG1/RPS27L 7 GO:0030041 actin filament polymerization 6/308 190/18722 0.0943722440615307 0.25899862817461 TMSB4X/GRB2/RAC1/MYADM/ARPC3/IQGAP2 6 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 3/308 66/18722 0.0948904949790779 0.259861291049438 HMGB2/SWAP70/HMGB1 3 GO:0016444 somatic cell DNA recombination 3/308 66/18722 0.0948904949790779 0.259861291049438 HMGB2/SWAP70/HMGB1 3 GO:0072678 T cell migration 3/308 66/18722 0.0948904949790779 0.259861291049438 CCL3/GPR183/CXCL10 3 GO:0090068 positive regulation of cell cycle process 7/308 236/18722 0.0957482253384868 0.262022523599882 PLSCR1/UBE2B/IL1B/EGFR/NPM1/HNRNPU/ANXA1 7 GO:0044262 cellular carbohydrate metabolic process 8/308 283/18722 0.0966198927998039 0.263067528183132 SNCA/PHLDA2/NUPR1/HK2/DDIT4/PTGES3/ISYNA1/HMGB1 8 GO:0010644 cell communication by electrical coupling 2/308 32/18722 0.0969558323855697 0.263067528183132 SRI/CALM1 2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 2/308 32/18722 0.0969558323855697 0.263067528183132 HSP90AB1/SDCBP 2 GO:0033687 osteoblast proliferation 2/308 32/18722 0.0969558323855697 0.263067528183132 JUNB/EIF2AK2 2 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 2/308 32/18722 0.0969558323855697 0.263067528183132 LARP7/HNRNPU 2 GO:0034367 protein-containing complex remodeling 2/308 32/18722 0.0969558323855697 0.263067528183132 APOE/APOC1 2 GO:0035767 endothelial cell chemotaxis 2/308 32/18722 0.0969558323855697 0.263067528183132 TMSB4X/HMGB1 2 GO:0050685 positive regulation of mRNA processing 2/308 32/18722 0.0969558323855697 0.263067528183132 NCL/CIRBP 2 GO:0090022 regulation of neutrophil chemotaxis 2/308 32/18722 0.0969558323855697 0.263067528183132 CXCL8/RAC1 2 GO:1901532 regulation of hematopoietic progenitor cell differentiation 2/308 32/18722 0.0969558323855697 0.263067528183132 EIF2AK2/HES1 2 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 2/308 32/18722 0.0969558323855697 0.263067528183132 HSP90AB1/SDCBP 2 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 2/308 32/18722 0.0969558323855697 0.263067528183132 HMGB1/ANXA1 2 GO:0001824 blastocyst development 4/308 106/18722 0.0976803017554608 0.264845243695835 KLF4/JUNB/SF3B6/SBDS 4 GO:0010212 response to ionizing radiation 5/308 148/18722 0.0978071135428989 0.26500113045677 RHOB/EGR1/GRB2/ANXA1/CXCL10 5 GO:0010517 regulation of phospholipase activity 3/308 67/18722 0.0981901295598054 0.265850471180691 SNCA/EGFR/ANXA1 3 GO:0016525 negative regulation of angiogenesis 5/308 149/18722 0.0999230631583025 0.270350934504027 KLF2/KLF4/STAT1/SERPINF1/CXCL10 5 GO:0006275 regulation of DNA replication 4/308 107/18722 0.10023496664041 0.271003025082241 JUN/CACYBP/EGFR/RAC1 4 GO:0042113 B cell activation 9/308 334/18722 0.101518201730195 0.27316743147152 KLF6/IRF8/SWAP70/TNFAIP3/GPR183/BST2/TNFSF13B/LAPTM5/LGALS1 9 GO:0009988 cell-cell recognition 3/308 68/18722 0.101535684049446 0.27316743147152 VDAC2/ALDOA/CD9 3 GO:0010812 negative regulation of cell-substrate adhesion 3/308 68/18722 0.101535684049446 0.27316743147152 FBLN1/GBP1/LGALS1 3 GO:0032922 circadian regulation of gene expression 3/308 68/18722 0.101535684049446 0.27316743147152 EGR1/BHLHE41/HNRNPU 3 GO:0042698 ovulation cycle 3/308 68/18722 0.101535684049446 0.27316743147152 EGR1/EGFR/SERPINF1 3 GO:0051926 negative regulation of calcium ion transport 3/308 68/18722 0.101535684049446 0.27316743147152 SRI/C4orf3/CALM1 3 GO:1902305 regulation of sodium ion transmembrane transport 3/308 68/18722 0.101535684049446 0.27316743147152 YWHAH/GLRX/FXYD3 3 GO:0001881 receptor recycling 2/308 33/18722 0.102132966881032 0.273427403631782 SNCA/CHMP5 2 GO:0001975 response to amphetamine 2/308 33/18722 0.102132966881032 0.273427403631782 NR4A2/CALM1 2 GO:0034110 regulation of homotypic cell-cell adhesion 2/308 33/18722 0.102132966881032 0.273427403631782 CD9/LGALS1 2 GO:0048048 embryonic eye morphogenesis 2/308 33/18722 0.102132966881032 0.273427403631782 FBN2/FBN1 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/308 33/18722 0.102132966881032 0.273427403631782 SUB1/HMGB1 2 GO:1903715 regulation of aerobic respiration 2/308 33/18722 0.102132966881032 0.273427403631782 SNCA/NUPR1 2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/308 33/18722 0.102132966881032 0.273427403631782 HSP90AB1/EGFR 2 GO:0050851 antigen receptor-mediated signaling pathway 7/308 240/18722 0.102275870323224 0.273618371060662 HLA-A/HLA-DRB1/HLA-DPB1/HLA-DQB1/NFKBIZ/GBP1/LAPTM5 7 GO:0140014 mitotic nuclear division 8/308 287/18722 0.102563464238453 0.274195890757766 DUSP1/CHMP1B/CHMP5/HSPA1A/IL1B/IK/HSPA1B/HNRNPU 8 GO:0007173 epidermal growth factor receptor signaling pathway 4/308 108/18722 0.102820400302154 0.274498875946323 IFI6/NCF1/GRB2/EGFR 4 GO:0033138 positive regulation of peptidyl-serine phosphorylation 4/308 108/18722 0.102820400302154 0.274498875946323 SNCA/HSP90AB1/EGFR/HSP90AA1 4 GO:0014706 striated muscle tissue development 10/308 384/18722 0.103494625486527 0.276106038545004 FOS/SAP30/LY6E/NUPR1/ATF3/CACYBP/EGR1/DSP/HNRNPU/DDX5 10 GO:0071824 protein-DNA complex subunit organization 7/308 241/18722 0.103944855213919 0.277113794618418 HMGB2/ANP32E/ANP32B/SET/NPM1/HMGB1/NAP1L1 7 GO:0043535 regulation of blood vessel endothelial cell migration 5/308 151/18722 0.104223508185297 0.277469687877709 KLF4/TMSB4X/APOE/HMGB1/ANXA1 5 GO:2000181 negative regulation of blood vessel morphogenesis 5/308 151/18722 0.104223508185297 0.277469687877709 KLF2/KLF4/STAT1/SERPINF1/CXCL10 5 GO:0033344 cholesterol efflux 3/308 69/18722 0.104926260280124 0.279146202540651 NFKBIA/APOE/APOC1 3 GO:0043393 regulation of protein binding 6/308 196/18722 0.105419439842274 0.27991865904853 B2M/IFIT1/PHLDA2/IFIT2/HSP90AB1/APOE 6 GO:0032410 negative regulation of transporter activity 4/308 109/18722 0.105436272307058 0.27991865904853 SNCA/SRI/C4orf3/CALM1 4 GO:0032414 positive regulation of ion transmembrane transporter activity 4/308 109/18722 0.105436272307058 0.27991865904853 TMSB4X/GLRX/CALM1/VMP1 4 GO:1901343 negative regulation of vasculature development 5/308 152/18722 0.10640769563083 0.282151775699013 KLF2/KLF4/STAT1/SERPINF1/CXCL10 5 GO:0071103 DNA conformation change 8/308 290/18722 0.107152679787917 0.282151775699013 HMGB2/ANP32B/CHD2/SET/NPM1/HMGB1/NAP1L1/ANXA1 8 GO:0000096 sulfur amino acid metabolic process 2/308 34/18722 0.107384471263945 0.282151775699013 COMT/SMS 2 GO:0002183 cytoplasmic translational initiation 2/308 34/18722 0.107384471263945 0.282151775699013 EIF4A2/EIF3E 2 GO:0007616 long-term memory 2/308 34/18722 0.107384471263945 0.282151775699013 APOE/SGK1 2 GO:0014072 response to isoquinoline alkaloid 2/308 34/18722 0.107384471263945 0.282151775699013 FOSB/CXCR4 2 GO:0030851 granulocyte differentiation 2/308 34/18722 0.107384471263945 0.282151775699013 TRIB1/C1QC 2 GO:0032212 positive regulation of telomere maintenance via telomerase 2/308 34/18722 0.107384471263945 0.282151775699013 HNRNPA1/PKIB 2 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2/308 34/18722 0.107384471263945 0.282151775699013 IFIH1/OAS3 2 GO:0043278 response to morphine 2/308 34/18722 0.107384471263945 0.282151775699013 FOSB/CXCR4 2 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 2/308 34/18722 0.107384471263945 0.282151775699013 NPM1/DDX5 2 GO:0050869 negative regulation of B cell activation 2/308 34/18722 0.107384471263945 0.282151775699013 TNFAIP3/LAPTM5 2 GO:0055094 response to lipoprotein particle 2/308 34/18722 0.107384471263945 0.282151775699013 APOE/CD9 2 GO:0086004 regulation of cardiac muscle cell contraction 2/308 34/18722 0.107384471263945 0.282151775699013 SRI/DSP 2 GO:1990000 amyloid fibril formation 2/308 34/18722 0.107384471263945 0.282151775699013 B2M/APOE 2 GO:0018958 phenol-containing compound metabolic process 4/308 110/18722 0.108082245074428 0.283400838765115 SNCA/LY6E/COMT/NR4A2 4 GO:0048259 regulation of receptor-mediated endocytosis 4/308 110/18722 0.108082245074428 0.283400838765115 B2M/SDCBP/RAC1/APOC1 4 GO:1905954 positive regulation of lipid localization 4/308 110/18722 0.108082245074428 0.283400838765115 NFKBIA/PLIN2/IL1B/APOE 4 GO:0002429 immune response-activating cell surface receptor signaling pathway 8/308 291/18722 0.10870731094771 0.284649349145955 HLA-A/HLA-DRB1/PLSCR1/HLA-DPB1/HLA-DQB1/NFKBIZ/GBP1/LAPTM5 8 GO:0002757 immune response-activating signal transduction 8/308 291/18722 0.10870731094771 0.284649349145955 HLA-A/HLA-DRB1/PLSCR1/HLA-DPB1/HLA-DQB1/NFKBIZ/GBP1/LAPTM5 8 GO:0048167 regulation of synaptic plasticity 6/308 198/18722 0.109245311235398 0.285862303116309 YWHAH/SNCA/VAMP2/PAIP2/RAB8A/APOE 6 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 4/308 111/18722 0.110757974147195 0.289622253874641 KLF4/NCF1/EGFR/FN1 4 GO:0006323 DNA packaging 6/308 199/18722 0.111184759432032 0.290539531994982 HMGB2/ANP32B/SET/NPM1/HMGB1/NAP1L1 6 GO:1901987 regulation of cell cycle phase transition 10/308 390/18722 0.111472245823184 0.291091800397562 KLF4/DUSP1/SYF2/BID/EGFR/IK/PSME2/NPM1/RPS27L/ANXA1 10 GO:0000281 mitotic cytokinesis 3/308 71/18722 0.111838848889242 0.291451887732496 CHMP1B/CHMP5/RHOB 3 GO:0033555 multicellular organismal response to stress 3/308 71/18722 0.111838848889242 0.291451887732496 COMT/NR4A2/APOE 3 GO:0043550 regulation of lipid kinase activity 3/308 71/18722 0.111838848889242 0.291451887732496 KLF4/NRBF2/SOCS3 3 GO:0001893 maternal placenta development 2/308 35/18722 0.112706517531309 0.291922097914767 JUNB/PRDX3 2 GO:0007020 microtubule nucleation 2/308 35/18722 0.112706517531309 0.291922097914767 HSPA1A/HSPA1B 2 GO:0032205 negative regulation of telomere maintenance 2/308 35/18722 0.112706517531309 0.291922097914767 HNRNPA1/HNRNPU 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/308 35/18722 0.112706517531309 0.291922097914767 HSP90AB1/SDCBP 2 GO:0034405 response to fluid shear stress 2/308 35/18722 0.112706517531309 0.291922097914767 KLF2/KLF4 2 GO:0039694 viral RNA genome replication 2/308 35/18722 0.112706517531309 0.291922097914767 CXCL8/APOBEC3A 2 GO:0045454 cell redox homeostasis 2/308 35/18722 0.112706517531309 0.291922097914767 PRDX3/PRDX1 2 GO:0046627 negative regulation of insulin receptor signaling pathway 2/308 35/18722 0.112706517531309 0.291922097914767 IL1B/SOCS3 2 GO:0070536 protein K63-linked deubiquitination 2/308 35/18722 0.112706517531309 0.291922097914767 TNFAIP3/OTUD1 2 GO:0000956 nuclear-transcribed mRNA catabolic process 4/308 112/18722 0.113463108459937 0.293484075536089 ZFP36/SSB/EIF3E/DDX5 4 GO:0010633 negative regulation of epithelial cell migration 4/308 112/18722 0.113463108459937 0.293484075536089 KLF4/SERPINF1/APOE/HMGB1 4 GO:0046879 hormone secretion 8/308 295/18722 0.115049368897513 0.296602770139467 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RAC1/ANXA1 8 GO:0065004 protein-DNA complex assembly 6/308 201/18722 0.115116208242383 0.296602770139467 HMGB2/ANP32B/SET/NPM1/HMGB1/NAP1L1 6 GO:0005977 glycogen metabolic process 3/308 72/18722 0.11535903114079 0.296602770139467 PHLDA2/PTGES3/HMGB1 3 GO:0030330 DNA damage response, signal transduction by p53 class mediator 3/308 72/18722 0.11535903114079 0.296602770139467 NPM1/DDX5/RPS27L 3 GO:0033045 regulation of sister chromatid segregation 3/308 72/18722 0.11535903114079 0.296602770139467 DUSP1/IK/HNRNPU 3 GO:0071479 cellular response to ionizing radiation 3/308 72/18722 0.11535903114079 0.296602770139467 RHOB/EGR1/GRB2 3 GO:1903036 positive regulation of response to wounding 3/308 72/18722 0.11535903114079 0.296602770139467 CXCR4/HMGB1/ANXA1 3 GO:1905818 regulation of chromosome separation 3/308 72/18722 0.11535903114079 0.296602770139467 PLSCR1/DUSP1/IK 3 GO:0001764 neuron migration 5/308 156/18722 0.115367072769392 0.296602770139467 DDIT4/CXCR4/PHACTR1/NR4A2/RAC1 5 GO:0051017 actin filament bundle assembly 5/308 157/18722 0.117661714618162 0.302194543708279 SWAP70/PTGER4/PHACTR1/RAC1/MARCKS 5 GO:0030224 monocyte differentiation 2/308 36/18722 0.118095382762273 0.302194543708279 JUN/HLA-DRB1 2 GO:0042092 type 2 immune response 2/308 36/18722 0.118095382762273 0.302194543708279 RSAD2/ANXA1 2 GO:0070873 regulation of glycogen metabolic process 2/308 36/18722 0.118095382762273 0.302194543708279 PHLDA2/HMGB1 2 GO:0071402 cellular response to lipoprotein particle stimulus 2/308 36/18722 0.118095382762273 0.302194543708279 APOE/CD9 2 GO:0097009 energy homeostasis 2/308 36/18722 0.118095382762273 0.302194543708279 METRNL/UBB 2 GO:1903539 protein localization to postsynaptic membrane 2/308 36/18722 0.118095382762273 0.302194543708279 VAMP2/RAB8A 2 GO:0006073 cellular glucan metabolic process 3/308 73/18722 0.118920576544952 0.30278607227485 PHLDA2/PTGES3/HMGB1 3 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 3/308 73/18722 0.118920576544952 0.30278607227485 IFI6/NCF1/EGFR 3 GO:0043299 leukocyte degranulation 3/308 73/18722 0.118920576544952 0.30278607227485 CCL3/VAMP2/HLA-F 3 GO:0044042 glucan metabolic process 3/308 73/18722 0.118920576544952 0.30278607227485 PHLDA2/PTGES3/HMGB1 3 GO:0051298 centrosome duplication 3/308 73/18722 0.118920576544952 0.30278607227485 CHMP1B/CHMP5/NPM1 3 GO:0002244 hematopoietic progenitor cell differentiation 4/308 114/18722 0.118960157090459 0.30278607227485 SBDS/EIF2AK2/CHD2/HES1 4 GO:0022904 respiratory electron transport chain 4/308 114/18722 0.118960157090459 0.30278607227485 SNCA/SDHD/BID/UQCR11 4 GO:1903008 organelle disassembly 4/308 114/18722 0.118960157090459 0.30278607227485 BNIP3L/GABARAPL2/HK2/MAP1LC3B 4 GO:0071560 cellular response to transforming growth factor beta stimulus 7/308 250/18722 0.119622317582267 0.304268875660019 JUN/FOS/FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1 7 GO:0043488 regulation of mRNA stability 5/308 158/18722 0.11997791706617 0.304970463393595 ZFP36/HNRNPM/CIRBP/NPM1/HNRNPU 5 GO:0070482 response to oxygen levels 9/308 347/18722 0.120405435777457 0.305853807958285 BNIP3L/CASP1/HK2/SOD2/DDIT4/EGR1/CXCR4/LDHA/NR4A2 9 GO:0006874 cellular calcium ion homeostasis 11/308 448/18722 0.122435616408371 0.310406719530637 CCL3/SNCA/SWAP70/CXCR4/SRI/PTGER4/HERPUD1/APOE/HMGB1/CALM1/CXCL10 11 GO:0002437 inflammatory response to antigenic stimulus 3/308 74/18722 0.122522558140657 0.310406719530637 HLA-DRB1/HMGB2/HMGB1 3 GO:0010822 positive regulation of mitochondrion organization 3/308 74/18722 0.122522558140657 0.310406719530637 RALA/BID/TNFSF10 3 GO:0070972 protein localization to endoplasmic reticulum 3/308 74/18722 0.122522558140657 0.310406719530637 PPP1R15A/GABARAPL2/HERPUD1 3 GO:0006623 protein targeting to vacuole 2/308 37/18722 0.12354744671546 0.311352596435863 GCC2/LAPTM5 2 GO:0043403 skeletal muscle tissue regeneration 2/308 37/18722 0.12354744671546 0.311352596435863 CD9/ANXA1 2 GO:0045730 respiratory burst 2/308 37/18722 0.12354744671546 0.311352596435863 NCF1/RAC1 2 GO:0062237 protein localization to postsynapse 2/308 37/18722 0.12354744671546 0.311352596435863 VAMP2/RAB8A 2 GO:0071985 multivesicular body sorting pathway 2/308 37/18722 0.12354744671546 0.311352596435863 CHMP1B/CHMP5 2 GO:0072529 pyrimidine-containing compound catabolic process 2/308 37/18722 0.12354744671546 0.311352596435863 TYMP/APOBEC3A 2 GO:1900077 negative regulation of cellular response to insulin stimulus 2/308 37/18722 0.12354744671546 0.311352596435863 IL1B/SOCS3 2 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 2/308 37/18722 0.12354744671546 0.311352596435863 HNRNPA1/PKIB 2 GO:0030518 intracellular steroid hormone receptor signaling pathway 4/308 116/18722 0.124570460281935 0.313365993196306 YWHAH/PTGES3/DNAJA1/DDX5 4 GO:0033559 unsaturated fatty acid metabolic process 4/308 116/18722 0.124570460281935 0.313365993196306 IL1B/PTGES3/CBR1/ANXA1 4 GO:0060402 calcium ion transport into cytosol 5/308 160/18722 0.1246742546826 0.313365993196306 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0090316 positive regulation of intracellular protein transport 5/308 160/18722 0.1246742546826 0.313365993196306 ANP32B/IL1B/VAMP2/HSP90AB1/OAZ1 5 GO:0033077 T cell differentiation in thymus 3/308 75/18722 0.126164045597117 0.316071524454639 B2M/IL1B/MAFB 3 GO:0034121 regulation of toll-like receptor signaling pathway 3/308 75/18722 0.126164045597117 0.316071524454639 TNFAIP3/RSAD2/HMGB1 3 GO:0036465 synaptic vesicle recycling 3/308 75/18722 0.126164045597117 0.316071524454639 SNCA/VAMP2/CALM1 3 GO:1902369 negative regulation of RNA catabolic process 3/308 75/18722 0.126164045597117 0.316071524454639 ZFP36/CIRBP/HNRNPU 3 GO:1903363 negative regulation of cellular protein catabolic process 3/308 75/18722 0.126164045597117 0.316071524454639 GABARAPL2/HSP90AB1/SDCBP 3 GO:0006839 mitochondrial transport 7/308 254/18722 0.12696213997821 0.317862646454943 HSPA1A/BNIP3L/MPC2/HK2/VDAC2/BID/HSP90AA1 7 GO:0061572 actin filament bundle organization 5/308 161/18722 0.127054005684822 0.317884465793898 SWAP70/PTGER4/PHACTR1/RAC1/MARCKS 5 GO:0001825 blastocyst formation 2/308 38/18722 0.129059189476496 0.319762334004306 JUNB/SF3B6 2 GO:0002385 mucosal immune response 2/308 38/18722 0.129059189476496 0.319762334004306 RPL39/DEFB1 2 GO:0006882 cellular zinc ion homeostasis 2/308 38/18722 0.129059189476496 0.319762334004306 S100A8/S100A9 2 GO:0007094 mitotic spindle assembly checkpoint signaling 2/308 38/18722 0.129059189476496 0.319762334004306 DUSP1/IK 2 GO:0010742 macrophage derived foam cell differentiation 2/308 38/18722 0.129059189476496 0.319762334004306 NFKBIA/STAT1 2 GO:0030279 negative regulation of ossification 2/308 38/18722 0.129059189476496 0.319762334004306 CCL3/SRGN 2 GO:0032373 positive regulation of sterol transport 2/308 38/18722 0.129059189476496 0.319762334004306 NFKBIA/APOE 2 GO:0032376 positive regulation of cholesterol transport 2/308 38/18722 0.129059189476496 0.319762334004306 NFKBIA/APOE 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/308 38/18722 0.129059189476496 0.319762334004306 SOD2/HES1 2 GO:0048713 regulation of oligodendrocyte differentiation 2/308 38/18722 0.129059189476496 0.319762334004306 CXCR4/HES1 2 GO:0051930 regulation of sensory perception of pain 2/308 38/18722 0.129059189476496 0.319762334004306 CCL3/COMT 2 GO:0071173 spindle assembly checkpoint signaling 2/308 38/18722 0.129059189476496 0.319762334004306 DUSP1/IK 2 GO:0071174 mitotic spindle checkpoint signaling 2/308 38/18722 0.129059189476496 0.319762334004306 DUSP1/IK 2 GO:0090077 foam cell differentiation 2/308 38/18722 0.129059189476496 0.319762334004306 NFKBIA/STAT1 2 GO:1903580 positive regulation of ATP metabolic process 2/308 38/18722 0.129059189476496 0.319762334004306 TMSB4X/NUPR1 2 GO:0034250 positive regulation of cellular amide metabolic process 5/308 162/18722 0.129454549150753 0.320326693464938 PPP1R15A/CIRBP/NPM1/EIF3E/RPS27L 5 GO:0051494 negative regulation of cytoskeleton organization 5/308 162/18722 0.129454549150753 0.320326693464938 SNCA/TMSB4X/SWAP70/MYADM/NPM1 5 GO:0051480 regulation of cytosolic calcium ion concentration 9/308 353/18722 0.129726500849429 0.320436140323272 CCL3/SNCA/SWAP70/CXCR4/SRI/PTGER4/HMGB1/CALM1/CXCL10 9 GO:0014823 response to activity 3/308 76/18722 0.129844105939174 0.320436140323272 SOD2/CXCR4/METRNL 3 GO:0021536 diencephalon development 3/308 76/18722 0.129844105939174 0.320436140323272 NR4A2/UBB/HES1 3 GO:0043536 positive regulation of blood vessel endothelial cell migration 3/308 76/18722 0.129844105939174 0.320436140323272 TMSB4X/HMGB1/ANXA1 3 GO:0060537 muscle tissue development 10/308 403/18722 0.129917870128452 0.320436140323272 FOS/SAP30/LY6E/NUPR1/ATF3/CACYBP/EGR1/DSP/HNRNPU/DDX5 10 GO:0045446 endothelial cell differentiation 4/308 118/18722 0.130290998284404 0.321149249800952 IL1B/CXCR4/BTG1/MYADM 4 GO:0071559 response to transforming growth factor beta 7/308 256/18722 0.130715870915682 0.321988901102224 JUN/FOS/FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1 7 GO:0006633 fatty acid biosynthetic process 5/308 163/18722 0.131875683812649 0.324636664015297 IL1B/PTGES3/CBR1/ANXA1/APOC1 5 GO:0031398 positive regulation of protein ubiquitination 4/308 119/18722 0.133191639299 0.327312036938925 NMI/NPM1/LAPTM5/UBB 4 GO:0009914 hormone transport 8/308 306/18722 0.133490799182998 0.327312036938925 HLA-DRB1/MPC2/ENSA/IL1B/SRI/EGFR/RAC1/ANXA1 8 GO:0002200 somatic diversification of immune receptors 3/308 77/18722 0.133561804243977 0.327312036938925 HMGB2/SWAP70/HMGB1 3 GO:0007492 endoderm development 3/308 77/18722 0.133561804243977 0.327312036938925 DUSP1/DUSP2/FN1 3 GO:0055117 regulation of cardiac muscle contraction 3/308 77/18722 0.133561804243977 0.327312036938925 SRI/DSP/CALM1 3 GO:0140056 organelle localization by membrane tethering 3/308 77/18722 0.133561804243977 0.327312036938925 RAB8A/CALM1/VMP1 3 GO:1901983 regulation of protein acetylation 3/308 77/18722 0.133561804243977 0.327312036938925 SNCA/IL1B/SET 3 GO:0007623 circadian rhythm 6/308 210/18722 0.133654190507265 0.327328616469745 JUND/JUN/EGR1/BHLHE41/EGFR/HNRNPU 6 GO:0050680 negative regulation of epithelial cell proliferation 5/308 164/18722 0.1343172049059 0.327404417390949 B2M/NUPR1/STAT1/SERPINF1/APOE 5 GO:0050806 positive regulation of synaptic transmission 5/308 164/18722 0.1343172049059 0.327404417390949 SNCA/VAMP2/PAIP2/EGFR/APOE 5 GO:0002701 negative regulation of production of molecular mediator of immune response 2/308 39/18722 0.13462718915474 0.327404417390949 HLA-F/BST2 2 GO:0016572 histone phosphorylation 2/308 39/18722 0.13462718915474 0.327404417390949 UBE2B/IL1B 2 GO:0031577 spindle checkpoint signaling 2/308 39/18722 0.13462718915474 0.327404417390949 DUSP1/IK 2 GO:0032506 cytokinetic process 2/308 39/18722 0.13462718915474 0.327404417390949 CHMP1B/CHMP5 2 GO:0034314 Arp2/3 complex-mediated actin nucleation 2/308 39/18722 0.13462718915474 0.327404417390949 ARPC3/IQGAP2 2 GO:0045923 positive regulation of fatty acid metabolic process 2/308 39/18722 0.13462718915474 0.327404417390949 IL1B/ANXA1 2 GO:0051931 regulation of sensory perception 2/308 39/18722 0.13462718915474 0.327404417390949 CCL3/COMT 2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 2/308 39/18722 0.13462718915474 0.327404417390949 CALM1/VMP1 2 GO:1903115 regulation of actin filament-based movement 2/308 39/18722 0.13462718915474 0.327404417390949 SRI/DSP 2 GO:0043491 protein kinase B signaling 6/308 211/18722 0.135797208190443 0.330039877248609 CCL3/KLF4/IL1B/HSP90AB1/EGFR/HSP90AA1 6 GO:0048675 axon extension 4/308 120/18722 0.136118670330891 0.330191419210022 HSP90AB1/APOE/FN1/HSP90AA1 4 GO:0051897 positive regulation of protein kinase B signaling 4/308 120/18722 0.136118670330891 0.330191419210022 CCL3/HSP90AB1/EGFR/HSP90AA1 4 GO:0071774 response to fibroblast growth factor 4/308 120/18722 0.136118670330891 0.330191419210022 IER2/SNCA/CXCL8/ZFP36 4 GO:0045927 positive regulation of growth 7/308 259/18722 0.136449522411361 0.330784099035278 CXCR4/BASP1/EGFR/SDCBP/S100A8/FN1/S100A9 7 GO:0032371 regulation of sterol transport 3/308 78/18722 0.137316204309822 0.332042915291871 NFKBIA/APOE/APOC1 3 GO:0032374 regulation of cholesterol transport 3/308 78/18722 0.137316204309822 0.332042915291871 NFKBIA/APOE/APOC1 3 GO:0043537 negative regulation of blood vessel endothelial cell migration 3/308 78/18722 0.137316204309822 0.332042915291871 KLF4/APOE/HMGB1 3 GO:1901616 organic hydroxy compound catabolic process 3/308 78/18722 0.137316204309822 0.332042915291871 COMT/ALDH2/APOE 3 GO:0001704 formation of primary germ layer 4/308 121/18722 0.139071692411314 0.33568295130047 KLF4/DUSP1/DUSP2/FN1 4 GO:0038127 ERBB signaling pathway 4/308 121/18722 0.139071692411314 0.33568295130047 IFI6/NCF1/GRB2/EGFR 4 GO:0055074 calcium ion homeostasis 11/308 460/18722 0.139170118032641 0.33568295130047 CCL3/SNCA/SWAP70/CXCR4/SRI/PTGER4/HERPUD1/APOE/HMGB1/CALM1/CXCL10 11 GO:0061013 regulation of mRNA catabolic process 5/308 166/18722 0.139260570432264 0.33568295130047 ZFP36/HNRNPM/CIRBP/NPM1/HNRNPU 5 GO:1902904 negative regulation of supramolecular fiber organization 5/308 166/18722 0.139260570432264 0.33568295130047 SNCA/TMSB4X/SWAP70/MYADM/APOE 5 GO:0007339 binding of sperm to zona pellucida 2/308 40/18722 0.14024811962826 0.33657787905765 VDAC2/ALDOA 2 GO:0010543 regulation of platelet activation 2/308 40/18722 0.14024811962826 0.33657787905765 APOE/CD9 2 GO:0030501 positive regulation of bone mineralization 2/308 40/18722 0.14024811962826 0.33657787905765 ISG15/FBN2 2 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/308 40/18722 0.14024811962826 0.33657787905765 DUSP1/IK 2 GO:0055069 zinc ion homeostasis 2/308 40/18722 0.14024811962826 0.33657787905765 S100A8/S100A9 2 GO:1901223 negative regulation of NIK/NF-kappaB signaling 2/308 40/18722 0.14024811962826 0.33657787905765 TMSB4X/NMI 2 GO:1901998 toxin transport 2/308 40/18722 0.14024811962826 0.33657787905765 CASP1/DNAJA1 2 GO:1901184 regulation of ERBB signaling pathway 3/308 79/18722 0.141106369297984 0.338425125361476 IFI6/NCF1/EGFR 3 GO:0031109 microtubule polymerization or depolymerization 4/308 122/18722 0.142050302475865 0.340475427188234 SNCA/HSPA1A/HSPA1B/RAC1 4 GO:0000082 G1/S transition of mitotic cell cycle 6/308 214/18722 0.142322968194606 0.340915230205501 KLF4/BID/EGFR/PSME2/RPS27L/ANXA1 6 GO:0023061 signal release 11/308 463/18722 0.143536652289051 0.343607151973101 HLA-DRB1/SNCA/MPC2/ENSA/IL1B/VAMP2/SRI/EGFR/RAC1/CALM1/ANXA1 11 GO:0000070 mitotic sister chromatid segregation 5/308 168/18722 0.14428294139916 0.344962533794644 DUSP1/CHMP1B/CHMP5/IK/HNRNPU 5 GO:0043588 skin development 7/308 263/18722 0.144283309321903 0.344962533794644 ZFP36/PTGES3/EGFR/DSP/ASAH1/ANXA1/TXNIP 7 GO:0009791 post-embryonic development 3/308 80/18722 0.14493136234832 0.345724314104029 KLF4/NR4A2/FBN1 3 GO:0032204 regulation of telomere maintenance 3/308 80/18722 0.14493136234832 0.345724314104029 HNRNPA1/HNRNPU/PKIB 3 GO:0048145 regulation of fibroblast proliferation 3/308 80/18722 0.14493136234832 0.345724314104029 NUPR1/FN1/S100A6 3 GO:0006690 icosanoid metabolic process 4/308 123/18722 0.145054093597401 0.345724314104029 IL1B/PTGES3/CBR1/ANXA1 4 GO:0030168 platelet activation 4/308 123/18722 0.145054093597401 0.345724314104029 PLSCR1/APOE/FN1/CD9 4 GO:0002251 organ or tissue specific immune response 2/308 41/18722 0.145918748336073 0.346059165563777 RPL39/DEFB1 2 GO:0050856 regulation of T cell receptor signaling pathway 2/308 41/18722 0.145918748336073 0.346059165563777 GBP1/LAPTM5 2 GO:0071634 regulation of transforming growth factor beta production 2/308 41/18722 0.145918748336073 0.346059165563777 HSP90AB1/FN1 2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 2/308 41/18722 0.145918748336073 0.346059165563777 RAC1/MYADM 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/308 41/18722 0.145918748336073 0.346059165563777 SNCA/TMSB4X 2 GO:1901385 regulation of voltage-gated calcium channel activity 2/308 41/18722 0.145918748336073 0.346059165563777 SRI/CALM1 2 GO:1902622 regulation of neutrophil migration 2/308 41/18722 0.145918748336073 0.346059165563777 CXCL8/RAC1 2 GO:1905521 regulation of macrophage migration 2/308 41/18722 0.145918748336073 0.346059165563777 CCL3/CD9 2 GO:0006605 protein targeting 8/308 314/18722 0.147795467157186 0.347908190435096 BNIP3L/NCF1/BID/HERPUD1/SDCBP/GCC2/HSP90AA1/LAPTM5 8 GO:0060249 anatomical structure homeostasis 8/308 314/18722 0.147795467157186 0.347908190435096 B2M/TNFAIP3/OAS1/EGFR/RAC1/ALDOA/CTSH/PRDX1 8 GO:0010508 positive regulation of autophagy 4/308 124/18722 0.148082655215375 0.347908190435096 BNIP3L/TRIM22/BID/HMGB1 4 GO:0001960 negative regulation of cytokine-mediated signaling pathway 3/308 81/18722 0.148790247169417 0.347908190435096 ISG15/OAS1/OAS3 3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 3/308 81/18722 0.148790247169417 0.347908190435096 FBN2/HSPA1A/FBN1 3 GO:0048144 fibroblast proliferation 3/308 81/18722 0.148790247169417 0.347908190435096 NUPR1/FN1/S100A6 3 GO:0043487 regulation of RNA stability 5/308 170/18722 0.149382563781656 0.347908190435096 ZFP36/HNRNPM/CIRBP/NPM1/HNRNPU 5 GO:0006417 regulation of translation 11/308 468/18722 0.150973343323561 0.347908190435096 PPP1R15A/NCL/ZFP36/EIF1B/PAIP2/EIF2AK2/CIRBP/EIF4A2/NPM1/EIF3E/RPS27L 11 GO:0051053 negative regulation of DNA metabolic process 4/308 125/18722 0.151135573361582 0.347908190435096 DUSP1/SUB1/HNRNPA1/HNRNPU 4 GO:0007163 establishment or maintenance of cell polarity 6/308 218/18722 0.151244687196027 0.347908190435096 RHOB/CCL4/HSP90AB1/RAC1/HSP90AA1/HES1 6 GO:0007520 myoblast fusion 2/308 42/18722 0.151635934116745 0.347908190435096 CD9/CXCL10 2 GO:0010677 negative regulation of cellular carbohydrate metabolic process 2/308 42/18722 0.151635934116745 0.347908190435096 NUPR1/DDIT4 2 GO:0010939 regulation of necrotic cell death 2/308 42/18722 0.151635934116745 0.347908190435096 NUPR1/ASAH1 2 GO:0030808 regulation of nucleotide biosynthetic process 2/308 42/18722 0.151635934116745 0.347908190435096 SNCA/TMSB4X 2 GO:0030890 positive regulation of B cell proliferation 2/308 42/18722 0.151635934116745 0.347908190435096 GPR183/TNFSF13B 2 GO:0045687 positive regulation of glial cell differentiation 2/308 42/18722 0.151635934116745 0.347908190435096 CXCR4/HES1 2 GO:0046688 response to copper ion 2/308 42/18722 0.151635934116745 0.347908190435096 SNCA/AOC1 2 GO:0072595 maintenance of protein localization in organelle 2/308 42/18722 0.151635934116745 0.347908190435096 HK2/HNRNPU 2 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/308 42/18722 0.151635934116745 0.347908190435096 DUSP1/IK 2 GO:0030833 regulation of actin filament polymerization 5/308 171/18722 0.151960783296028 0.347908190435096 TMSB4X/GRB2/MYADM/ARPC3/IQGAP2 5 GO:0048469 cell maturation 5/308 171/18722 0.151960783296028 0.347908190435096 KLF2/NR4A2/DEFB1/HES1/C1QA 5 GO:0007032 endosome organization 3/308 82/18722 0.152682088604046 0.347908190435096 CHMP1B/CHMP5/SNX3 3 GO:0046889 positive regulation of lipid biosynthetic process 3/308 82/18722 0.152682088604046 0.347908190435096 IL1B/APOE/ANXA1 3 GO:0060395 SMAD protein signal transduction 3/308 82/18722 0.152682088604046 0.347908190435096 JUN/FOS/SUB1 3 GO:0072527 pyrimidine-containing compound metabolic process 3/308 82/18722 0.152682088604046 0.347908190435096 TYMP/NT5C3A/APOBEC3A 3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1/308 10/18722 0.152886675367764 0.347908190435096 APBB1IP 1 GO:0002934 desmosome organization 1/308 10/18722 0.152886675367764 0.347908190435096 DSP 1 GO:0006735 NADH regeneration 1/308 10/18722 0.152886675367764 0.347908190435096 HK2 1 GO:0010728 regulation of hydrogen peroxide biosynthetic process 1/308 10/18722 0.152886675367764 0.347908190435096 SOD2 1 GO:0010944 negative regulation of transcription by competitive promoter binding 1/308 10/18722 0.152886675367764 0.347908190435096 BHLHE41 1 GO:0017085 response to insecticide 1/308 10/18722 0.152886675367764 0.347908190435096 UBA52 1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 1/308 10/18722 0.152886675367764 0.347908190435096 P4HA1 1 GO:0019062 virion attachment to host cell 1/308 10/18722 0.152886675367764 0.347908190435096 HSP90AB1 1 GO:0019614 catechol-containing compound catabolic process 1/308 10/18722 0.152886675367764 0.347908190435096 COMT 1 GO:0021903 rostrocaudal neural tube patterning 1/308 10/18722 0.152886675367764 0.347908190435096 HES1 1 GO:0030388 fructose 1,6-bisphosphate metabolic process 1/308 10/18722 0.152886675367764 0.347908190435096 ALDOA 1 GO:0032025 response to cobalt ion 1/308 10/18722 0.152886675367764 0.347908190435096 SERPINF1 1 GO:0033080 immature T cell proliferation in thymus 1/308 10/18722 0.152886675367764 0.347908190435096 IL1B 1 GO:0034756 regulation of iron ion transport 1/308 10/18722 0.152886675367764 0.347908190435096 B2M 1 GO:0035871 protein K11-linked deubiquitination 1/308 10/18722 0.152886675367764 0.347908190435096 TNFAIP3 1 GO:0036363 transforming growth factor beta activation 1/308 10/18722 0.152886675367764 0.347908190435096 HSP90AB1 1 GO:0042424 catecholamine catabolic process 1/308 10/18722 0.152886675367764 0.347908190435096 COMT 1 GO:0042989 sequestering of actin monomers 1/308 10/18722 0.152886675367764 0.347908190435096 TMSB4X 1 GO:0045625 regulation of T-helper 1 cell differentiation 1/308 10/18722 0.152886675367764 0.347908190435096 ANXA1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/308 10/18722 0.152886675367764 0.347908190435096 HMGB1 1 GO:0048241 epinephrine transport 1/308 10/18722 0.152886675367764 0.347908190435096 LY6E 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/308 10/18722 0.152886675367764 0.347908190435096 CALM1 1 GO:0051351 positive regulation of ligase activity 1/308 10/18722 0.152886675367764 0.347908190435096 TMSB4X 1 GO:0051409 response to nitrosative stress 1/308 10/18722 0.152886675367764 0.347908190435096 DNAJA1 1 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 1/308 10/18722 0.152886675367764 0.347908190435096 PLSCR1 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/308 10/18722 0.152886675367764 0.347908190435096 SERPINF1 1 GO:0061621 canonical glycolysis 1/308 10/18722 0.152886675367764 0.347908190435096 HK2 1 GO:0061718 glucose catabolic process to pyruvate 1/308 10/18722 0.152886675367764 0.347908190435096 HK2 1 GO:0070383 DNA cytosine deamination 1/308 10/18722 0.152886675367764 0.347908190435096 APOBEC3A 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/308 10/18722 0.152886675367764 0.347908190435096 EGR1 1 GO:0090043 regulation of tubulin deacetylation 1/308 10/18722 0.152886675367764 0.347908190435096 BEX4 1 GO:0090209 negative regulation of triglyceride metabolic process 1/308 10/18722 0.152886675367764 0.347908190435096 APOE 1 GO:0090647 modulation of age-related behavioral decline 1/308 10/18722 0.152886675367764 0.347908190435096 B2M 1 GO:0097084 vascular associated smooth muscle cell development 1/308 10/18722 0.152886675367764 0.347908190435096 HES1 1 GO:0097278 complement-dependent cytotoxicity 1/308 10/18722 0.152886675367764 0.347908190435096 HSP90AB1 1 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/308 10/18722 0.152886675367764 0.347908190435096 RAB8A 1 GO:0140059 dendrite arborization 1/308 10/18722 0.152886675367764 0.347908190435096 PHACTR1 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/308 10/18722 0.152886675367764 0.347908190435096 APOC1 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/308 10/18722 0.152886675367764 0.347908190435096 NCL 1 GO:1903867 extraembryonic membrane development 1/308 10/18722 0.152886675367764 0.347908190435096 DNAJB6 1 GO:1903980 positive regulation of microglial cell activation 1/308 10/18722 0.152886675367764 0.347908190435096 CCL3 1 GO:1905456 regulation of lymphoid progenitor cell differentiation 1/308 10/18722 0.152886675367764 0.347908190435096 HES1 1 GO:2000425 regulation of apoptotic cell clearance 1/308 10/18722 0.152886675367764 0.347908190435096 HMGB1 1 GO:0001894 tissue homeostasis 7/308 268/18722 0.154371236232965 0.351077475382882 B2M/TNFAIP3/OAS1/EGFR/RAC1/CTSH/PRDX1 7 GO:1990138 neuron projection extension 5/308 172/18722 0.154557636960291 0.351292417419259 CXCR4/HSP90AB1/APOE/FN1/HSP90AA1 5 GO:0015980 energy derivation by oxidation of organic compounds 8/308 318/18722 0.155218848166861 0.352585654510939 SNCA/PHLDA2/NUPR1/SDHD/PTGES3/BID/HMGB1/UQCR11 8 GO:0033046 negative regulation of sister chromatid segregation 2/308 43/18722 0.157396625092395 0.356051655460488 DUSP1/IK 2 GO:0033048 negative regulation of mitotic sister chromatid segregation 2/308 43/18722 0.157396625092395 0.356051655460488 DUSP1/IK 2 GO:0045776 negative regulation of blood pressure 2/308 43/18722 0.157396625092395 0.356051655460488 SCPEP1/SOD2 2 GO:0046636 negative regulation of alpha-beta T cell activation 2/308 43/18722 0.157396625092395 0.356051655460488 HMGB1/ANXA1 2 GO:0071604 transforming growth factor beta production 2/308 43/18722 0.157396625092395 0.356051655460488 HSP90AB1/FN1 2 GO:1903793 positive regulation of anion transport 2/308 43/18722 0.157396625092395 0.356051655460488 CEBPB/IL1B 2 GO:2000816 negative regulation of mitotic sister chromatid separation 2/308 43/18722 0.157396625092395 0.356051655460488 DUSP1/IK 2 GO:0008406 gonad development 6/308 221/18722 0.158096662359998 0.35721249420938 CEBPB/HMGB2/NUPR1/BASP1/TNFSF10/UBB 6 GO:0010810 regulation of cell-substrate adhesion 6/308 221/18722 0.158096662359998 0.35721249420938 FBLN1/GBP1/RAC1/MYADM/FN1/LGALS1 6 GO:0006816 calcium ion transport 10/308 422/18722 0.159634615808643 0.360474386436175 CCL3/SNCA/SARAF/CCL4/CXCR4/SRI/C4orf3/CALM1/VMP1/CXCL10 10 GO:0015931 nucleobase-containing compound transport 6/308 222/18722 0.16041049278031 0.360946116240421 MX2/ZFP36/SSB/SRSF3/HNRNPA1/NPM1 6 GO:0006112 energy reserve metabolic process 3/308 84/18722 0.16056090958159 0.360946116240421 PHLDA2/PTGES3/HMGB1 3 GO:0006970 response to osmotic stress 3/308 84/18722 0.16056090958159 0.360946116240421 TSC22D3/HSP90AB1/EGFR 3 GO:0010921 regulation of phosphatase activity 3/308 84/18722 0.16056090958159 0.360946116240421 PPP1R15A/HSP90AB1/CALM1 3 GO:0032370 positive regulation of lipid transport 3/308 84/18722 0.16056090958159 0.360946116240421 NFKBIA/IL1B/APOE 3 GO:0001667 ameboidal-type cell migration 11/308 475/18722 0.161712574367063 0.360946116240421 KLF4/TMSB4X/RHOB/SERPINF1/RAC1/APOE/HMGB1/FN1/CTSH/ANXA1/S100P 11 GO:0051962 positive regulation of nervous system development 7/308 272/18722 0.162670766839658 0.360946116240421 IL1B/CXCR4/EGFR/SERPINF1/FN1/NAP1L1/HES1 7 GO:0030521 androgen receptor signaling pathway 2/308 44/18722 0.163197856597231 0.360946116240421 DNAJA1/DDX5 2 GO:0031295 T cell costimulation 2/308 44/18722 0.163197856597231 0.360946116240421 TNFSF13B/LGALS1 2 GO:0032881 regulation of polysaccharide metabolic process 2/308 44/18722 0.163197856597231 0.360946116240421 PHLDA2/HMGB1 2 GO:0042554 superoxide anion generation 2/308 44/18722 0.163197856597231 0.360946116240421 NCF1/EGFR 2 GO:0044058 regulation of digestive system process 2/308 44/18722 0.163197856597231 0.360946116240421 TYMP/SGK1 2 GO:0045124 regulation of bone resorption 2/308 44/18722 0.163197856597231 0.360946116240421 TNFAIP3/EGFR 2 GO:0007093 mitotic cell cycle checkpoint signaling 4/308 129/18722 0.163582424931481 0.360946116240421 DUSP1/SYF2/IK/RPS27L 4 GO:0010507 negative regulation of autophagy 3/308 85/18722 0.164546029238825 0.360946116240421 SNCA/NUPR1/MCL1 3 GO:0032092 positive regulation of protein binding 3/308 85/18722 0.164546029238825 0.360946116240421 B2M/HSP90AB1/APOE 3 GO:0034249 negative regulation of cellular amide metabolic process 7/308 273/18722 0.164776650457385 0.360946116240421 NCL/ZFP36/PAIP2/EIF2AK2/CIRBP/APOE/EIF3E 7 GO:0043534 blood vessel endothelial cell migration 5/308 176/18722 0.16512671866627 0.360946116240421 KLF4/TMSB4X/APOE/HMGB1/ANXA1 5 GO:0006956 complement activation 4/308 130/18722 0.166750812268919 0.360946116240421 IL1B/CFD/C1QC/C1QA 4 GO:0051028 mRNA transport 4/308 130/18722 0.166750812268919 0.360946116240421 MX2/ZFP36/SRSF3/HNRNPA1 4 GO:0001660 fever generation 1/308 11/18722 0.166830182421351 0.360946116240421 IL1B 1 GO:0002725 negative regulation of T cell cytokine production 1/308 11/18722 0.166830182421351 0.360946116240421 HLA-F 1 GO:0003263 cardioblast proliferation 1/308 11/18722 0.166830182421351 0.360946116240421 HES1 1 GO:0003264 regulation of cardioblast proliferation 1/308 11/18722 0.166830182421351 0.360946116240421 HES1 1 GO:0006002 fructose 6-phosphate metabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 HK2 1 GO:0006020 inositol metabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 ISYNA1 1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/308 11/18722 0.166830182421351 0.360946116240421 MPC2 1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1/308 11/18722 0.166830182421351 0.360946116240421 UQCR11 1 GO:0006707 cholesterol catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 APOE 1 GO:0007144 female meiosis I 1/308 11/18722 0.166830182421351 0.360946116240421 UBB 1 GO:0010269 response to selenium ion 1/308 11/18722 0.166830182421351 0.360946116240421 SOD2 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/308 11/18722 0.166830182421351 0.360946116240421 BID 1 GO:0016127 sterol catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 APOE 1 GO:0031652 positive regulation of heat generation 1/308 11/18722 0.166830182421351 0.360946116240421 IL1B 1 GO:0032308 positive regulation of prostaglandin secretion 1/308 11/18722 0.166830182421351 0.360946116240421 IL1B 1 GO:0032610 interleukin-1 alpha production 1/308 11/18722 0.166830182421351 0.360946116240421 CASP1 1 GO:0032650 regulation of interleukin-1 alpha production 1/308 11/18722 0.166830182421351 0.360946116240421 CASP1 1 GO:0033083 regulation of immature T cell proliferation 1/308 11/18722 0.166830182421351 0.360946116240421 IL1B 1 GO:0033483 gas homeostasis 1/308 11/18722 0.166830182421351 0.360946116240421 SOD2 1 GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/308 11/18722 0.166830182421351 0.360946116240421 SWAP70 1 GO:0034379 very-low-density lipoprotein particle assembly 1/308 11/18722 0.166830182421351 0.360946116240421 APOC1 1 GO:0034776 response to histamine 1/308 11/18722 0.166830182421351 0.360946116240421 AOC1 1 GO:0035246 peptidyl-arginine N-methylation 1/308 11/18722 0.166830182421351 0.360946116240421 PRMT9 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/308 11/18722 0.166830182421351 0.360946116240421 PPP1R15A 1 GO:0042135 neurotransmitter catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 COMT 1 GO:0042167 heme catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 BLVRA 1 GO:0045628 regulation of T-helper 2 cell differentiation 1/308 11/18722 0.166830182421351 0.360946116240421 ANXA1 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/308 11/18722 0.166830182421351 0.360946116240421 HMGB2 1 GO:0045793 positive regulation of cell size 1/308 11/18722 0.166830182421351 0.360946116240421 HSP90AB1 1 GO:0046149 pigment catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 BLVRA 1 GO:0048102 autophagic cell death 1/308 11/18722 0.166830182421351 0.360946116240421 LAPTM5 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/308 11/18722 0.166830182421351 0.360946116240421 HES1 1 GO:0051132 NK T cell activation 1/308 11/18722 0.166830182421351 0.360946116240421 HSPH1 1 GO:0051610 serotonin uptake 1/308 11/18722 0.166830182421351 0.360946116240421 SNCA 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/308 11/18722 0.166830182421351 0.360946116240421 SERPINF1 1 GO:0070417 cellular response to cold 1/308 11/18722 0.166830182421351 0.360946116240421 NFKBIA 1 GO:0071044 histone mRNA catabolic process 1/308 11/18722 0.166830182421351 0.360946116240421 SSB 1 GO:0071609 chemokine (C-C motif) ligand 5 production 1/308 11/18722 0.166830182421351 0.360946116240421 OAS3 1 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 1/308 11/18722 0.166830182421351 0.360946116240421 OAS3 1 GO:0072110 glomerular mesangial cell proliferation 1/308 11/18722 0.166830182421351 0.360946116240421 EGR1 1 GO:0072173 metanephric tubule morphogenesis 1/308 11/18722 0.166830182421351 0.360946116240421 HES1 1 GO:0075522 IRES-dependent viral translational initiation 1/308 11/18722 0.166830182421351 0.360946116240421 SSB 1 GO:0075733 intracellular transport of virus 1/308 11/18722 0.166830182421351 0.360946116240421 BST2 1 GO:0090160 Golgi to lysosome transport 1/308 11/18722 0.166830182421351 0.360946116240421 LAPTM5 1 GO:0098935 dendritic transport 1/308 11/18722 0.166830182421351 0.360946116240421 HNRNPU 1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 1/308 11/18722 0.166830182421351 0.360946116240421 HES1 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/308 11/18722 0.166830182421351 0.360946116240421 EIF2AK2 1 GO:1902093 positive regulation of flagellated sperm motility 1/308 11/18722 0.166830182421351 0.360946116240421 DEFB1 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/308 11/18722 0.166830182421351 0.360946116240421 PPP1R15A 1 GO:1904869 regulation of protein localization to Cajal body 1/308 11/18722 0.166830182421351 0.360946116240421 LARP7 1 GO:1904871 positive regulation of protein localization to Cajal body 1/308 11/18722 0.166830182421351 0.360946116240421 LARP7 1 GO:2000155 positive regulation of cilium-dependent cell motility 1/308 11/18722 0.166830182421351 0.360946116240421 DEFB1 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/308 11/18722 0.166830182421351 0.360946116240421 HMGB1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/308 11/18722 0.166830182421351 0.360946116240421 PKIB 1 GO:0071466 cellular response to xenobiotic stimulus 5/308 177/18722 0.167813216095339 0.362845307130477 IL1B/CXCR4/EGFR/CBR1/APOBEC3A 5 GO:0032413 negative regulation of ion transmembrane transporter activity 3/308 86/18722 0.168560386707739 0.362845307130477 SRI/C4orf3/CALM1 3 GO:0045921 positive regulation of exocytosis 3/308 86/18722 0.168560386707739 0.362845307130477 SNCA/HLA-F/SDCBP 3 GO:0006110 regulation of glycolytic process 2/308 45/18722 0.16903674914972 0.362845307130477 NUPR1/DDIT4 2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 2/308 45/18722 0.16903674914972 0.362845307130477 SOD2/MCL1 2 GO:0030850 prostate gland development 2/308 45/18722 0.16903674914972 0.362845307130477 SERPINF1/ANXA1 2 GO:0032309 icosanoid secretion 2/308 45/18722 0.16903674914972 0.362845307130477 IL1B/ANXA1 2 GO:0035384 thioester biosynthetic process 2/308 45/18722 0.16903674914972 0.362845307130477 SNCA/MPC2 2 GO:0042551 neuron maturation 2/308 45/18722 0.16903674914972 0.362845307130477 NR4A2/C1QA 2 GO:0046189 phenol-containing compound biosynthetic process 2/308 45/18722 0.16903674914972 0.362845307130477 SNCA/NR4A2 2 GO:0048538 thymus development 2/308 45/18722 0.16903674914972 0.362845307130477 MAFB/HES1 2 GO:0051985 negative regulation of chromosome segregation 2/308 45/18722 0.16903674914972 0.362845307130477 DUSP1/IK 2 GO:0071616 acyl-CoA biosynthetic process 2/308 45/18722 0.16903674914972 0.362845307130477 SNCA/MPC2 2 GO:1905819 negative regulation of chromosome separation 2/308 45/18722 0.16903674914972 0.362845307130477 DUSP1/IK 2 GO:0006109 regulation of carbohydrate metabolic process 5/308 178/18722 0.170516920485656 0.365817164431348 SNCA/PHLDA2/NUPR1/DDIT4/HMGB1 5 GO:0045137 development of primary sexual characteristics 6/308 227/18722 0.172196675747251 0.369213623882076 CEBPB/HMGB2/NUPR1/BASP1/TNFSF10/UBB 6 GO:0019646 aerobic electron transport chain 3/308 87/18722 0.172603060169746 0.369463325324155 SNCA/SDHD/UQCR11 3 GO:0044070 regulation of anion transport 3/308 87/18722 0.172603060169746 0.369463325324155 SNCA/CEBPB/IL1B 3 GO:1900182 positive regulation of protein localization to nucleus 3/308 87/18722 0.172603060169746 0.369463325324155 HSP90AB1/LARP7/NPM1 3 GO:0006941 striated muscle contraction 5/308 179/18722 0.17323758620816 0.369856152436342 CXCR4/SRI/DSP/ALDOA/CALM1 5 GO:1901991 negative regulation of mitotic cell cycle phase transition 5/308 179/18722 0.17323758620816 0.369856152436342 KLF4/DUSP1/SYF2/IK/RPS27L 5 GO:0006984 ER-nucleus signaling pathway 2/308 46/18722 0.17491050646752 0.369856152436342 PPP1R15A/BID 2 GO:0031018 endocrine pancreas development 2/308 46/18722 0.17491050646752 0.369856152436342 HES1/ANXA1 2 GO:0031294 lymphocyte costimulation 2/308 46/18722 0.17491050646752 0.369856152436342 TNFSF13B/LGALS1 2 GO:0031648 protein destabilization 2/308 46/18722 0.17491050646752 0.369856152436342 SNCA/CTSH 2 GO:0034198 cellular response to amino acid starvation 2/308 46/18722 0.17491050646752 0.369856152436342 ATF3/EIF2AK2 2 GO:0055010 ventricular cardiac muscle tissue morphogenesis 2/308 46/18722 0.17491050646752 0.369856152436342 LY6E/DSP 2 GO:0061028 establishment of endothelial barrier 2/308 46/18722 0.17491050646752 0.369856152436342 IL1B/MYADM 2 GO:0061462 protein localization to lysosome 2/308 46/18722 0.17491050646752 0.369856152436342 GCC2/LAPTM5 2 GO:0071827 plasma lipoprotein particle organization 2/308 46/18722 0.17491050646752 0.369856152436342 APOE/APOC1 2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 2/308 46/18722 0.17491050646752 0.369856152436342 EGFR/ANXA1 2 GO:1900271 regulation of long-term synaptic potentiation 2/308 46/18722 0.17491050646752 0.369856152436342 PAIP2/APOE 2 GO:0050829 defense response to Gram-negative bacterium 3/308 88/18722 0.176673131854336 0.369856152436342 HMGB2/CASP1/DEFB1 3 GO:1901657 glycosyl compound metabolic process 3/308 88/18722 0.176673131854336 0.369856152436342 TYMP/NT5C3A/APOBEC3A 3 GO:0008361 regulation of cell size 5/308 181/18722 0.178728809357382 0.369856152436342 HSP90AB1/RAC1/NPM1/APOE/FN1 5 GO:1905952 regulation of lipid localization 5/308 181/18722 0.178728809357382 0.369856152436342 NFKBIA/PLIN2/IL1B/APOE/APOC1 5 GO:0001508 action potential 4/308 134/18722 0.179638168418417 0.369856152436342 YWHAH/SRI/DSP/CALM1 4 GO:0019216 regulation of lipid metabolic process 8/308 331/18722 0.180528373106667 0.369856152436342 SNCA/IL1B/EGR1/IGFBP7/APOE/ASAH1/ANXA1/APOC1 8 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/308 12/18722 0.180544911928819 0.369856152436342 SOD2 1 GO:0002182 cytoplasmic translational elongation 1/308 12/18722 0.180544911928819 0.369856152436342 RPLP2 1 GO:0002328 pro-B cell differentiation 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0002664 regulation of T cell tolerance induction 1/308 12/18722 0.180544911928819 0.369856152436342 HLA-B 1 GO:0003353 positive regulation of cilium movement 1/308 12/18722 0.180544911928819 0.369856152436342 DEFB1 1 GO:0006068 ethanol catabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 ALDH2 1 GO:0006216 cytidine catabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 APOBEC3A 1 GO:0006787 porphyrin-containing compound catabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 BLVRA 1 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 TYMP 1 GO:0009886 post-embryonic animal morphogenesis 1/308 12/18722 0.180544911928819 0.369856152436342 FBN1 1 GO:0009972 cytidine deamination 1/308 12/18722 0.180544911928819 0.369856152436342 APOBEC3A 1 GO:0010454 negative regulation of cell fate commitment 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0010459 negative regulation of heart rate 1/308 12/18722 0.180544911928819 0.369856152436342 SRI 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/308 12/18722 0.180544911928819 0.369856152436342 SNCA 1 GO:0010826 negative regulation of centrosome duplication 1/308 12/18722 0.180544911928819 0.369856152436342 NPM1 1 GO:0016554 cytidine to uridine editing 1/308 12/18722 0.180544911928819 0.369856152436342 APOBEC3A 1 GO:0031126 sno(s)RNA 3'-end processing 1/308 12/18722 0.180544911928819 0.369856152436342 LARP7 1 GO:0032306 regulation of prostaglandin secretion 1/308 12/18722 0.180544911928819 0.369856152436342 IL1B 1 GO:0033015 tetrapyrrole catabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 BLVRA 1 GO:0033079 immature T cell proliferation 1/308 12/18722 0.180544911928819 0.369856152436342 IL1B 1 GO:0033629 negative regulation of cell adhesion mediated by integrin 1/308 12/18722 0.180544911928819 0.369856152436342 SWAP70 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/308 12/18722 0.180544911928819 0.369856152436342 HMGB1 1 GO:0034154 toll-like receptor 7 signaling pathway 1/308 12/18722 0.180544911928819 0.369856152436342 RSAD2 1 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1/308 12/18722 0.180544911928819 0.369856152436342 APOE 1 GO:0034372 very-low-density lipoprotein particle remodeling 1/308 12/18722 0.180544911928819 0.369856152436342 APOE 1 GO:0042118 endothelial cell activation 1/308 12/18722 0.180544911928819 0.369856152436342 CXCL10 1 GO:0043301 negative regulation of leukocyte degranulation 1/308 12/18722 0.180544911928819 0.369856152436342 HLA-F 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 HMGB1 1 GO:0044650 adhesion of symbiont to host cell 1/308 12/18722 0.180544911928819 0.369856152436342 HSP90AB1 1 GO:0045605 negative regulation of epidermal cell differentiation 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0045683 negative regulation of epidermis development 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0046087 cytidine metabolic process 1/308 12/18722 0.180544911928819 0.369856152436342 APOBEC3A 1 GO:0046606 negative regulation of centrosome cycle 1/308 12/18722 0.180544911928819 0.369856152436342 NPM1 1 GO:0051095 regulation of helicase activity 1/308 12/18722 0.180544911928819 0.369856152436342 IFIT1 1 GO:0051340 regulation of ligase activity 1/308 12/18722 0.180544911928819 0.369856152436342 TMSB4X 1 GO:0051583 dopamine uptake involved in synaptic transmission 1/308 12/18722 0.180544911928819 0.369856152436342 SNCA 1 GO:0051934 catecholamine uptake involved in synaptic transmission 1/308 12/18722 0.180544911928819 0.369856152436342 SNCA 1 GO:0060019 radial glial cell differentiation 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0060453 regulation of gastric acid secretion 1/308 12/18722 0.180544911928819 0.369856152436342 SGK1 1 GO:0060907 positive regulation of macrophage cytokine production 1/308 12/18722 0.180544911928819 0.369856152436342 LAPTM5 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/308 12/18722 0.180544911928819 0.369856152436342 HES1 1 GO:0061430 bone trabecula morphogenesis 1/308 12/18722 0.180544911928819 0.369856152436342 FBN2 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/308 12/18722 0.180544911928819 0.369856152436342 HK2 1 GO:0071872 cellular response to epinephrine stimulus 1/308 12/18722 0.180544911928819 0.369856152436342 SNCA 1 GO:0072182 regulation of nephron tubule epithelial cell differentiation 1/308 12/18722 0.180544911928819 0.369856152436342 STAT1 1 GO:0072520 seminiferous tubule development 1/308 12/18722 0.180544911928819 0.369856152436342 UBB 1 GO:0090331 negative regulation of platelet aggregation 1/308 12/18722 0.180544911928819 0.369856152436342 CD9 1 GO:0090677 reversible differentiation 1/308 12/18722 0.180544911928819 0.369856152436342 SOD2 1 GO:0098911 regulation of ventricular cardiac muscle cell action potential 1/308 12/18722 0.180544911928819 0.369856152436342 DSP 1 GO:1902950 regulation of dendritic spine maintenance 1/308 12/18722 0.180544911928819 0.369856152436342 APOE 1 GO:1903405 protein localization to nuclear body 1/308 12/18722 0.180544911928819 0.369856152436342 LARP7 1 GO:1904867 protein localization to Cajal body 1/308 12/18722 0.180544911928819 0.369856152436342 LARP7 1 GO:1905214 regulation of RNA binding 1/308 12/18722 0.180544911928819 0.369856152436342 EIF3E 1 GO:1905709 negative regulation of membrane permeability 1/308 12/18722 0.180544911928819 0.369856152436342 HK2 1 GO:1990034 calcium ion export across plasma membrane 1/308 12/18722 0.180544911928819 0.369856152436342 CALM1 1 GO:2001204 regulation of osteoclast development 1/308 12/18722 0.180544911928819 0.369856152436342 FBN1 1 GO:0007595 lactation 2/308 47/18722 0.180816413524333 0.369856152436342 HK2/OAS2 2 GO:0010799 regulation of peptidyl-threonine phosphorylation 2/308 47/18722 0.180816413524333 0.369856152436342 DDIT4/CALM1 2 GO:0035850 epithelial cell differentiation involved in kidney development 2/308 47/18722 0.180816413524333 0.369856152436342 BASP1/STAT1 2 GO:0045581 negative regulation of T cell differentiation 2/308 47/18722 0.180816413524333 0.369856152436342 HMGB1/ANXA1 2 GO:0045601 regulation of endothelial cell differentiation 2/308 47/18722 0.180816413524333 0.369856152436342 IL1B/BTG1 2 GO:0046677 response to antibiotic 2/308 47/18722 0.180816413524333 0.369856152436342 AOC1/HSP90AA1 2 GO:0048483 autonomic nervous system development 2/308 47/18722 0.180816413524333 0.369856152436342 FN1/HES1 2 GO:0060401 cytosolic calcium ion transport 5/308 182/18722 0.181498866020078 0.371053564061369 CCL3/SNCA/SRI/CALM1/CXCL10 5 GO:0048285 organelle fission 11/308 488/18722 0.182634611722407 0.373175906261229 DUSP1/CHMP1B/CHMP5/HSPA1A/UBE2B/IL1B/RALA/IK/HSPA1B/HNRNPU/UBB 11 GO:0001101 response to acid chemical 4/308 135/18722 0.182911287957576 0.373541588601395 KLF2/CEBPB/KRT8/CD9 4 GO:0002028 regulation of sodium ion transport 3/308 90/18722 0.184891821502923 0.376982097923026 YWHAH/GLRX/FXYD3 3 GO:0046849 bone remodeling 3/308 90/18722 0.184891821502923 0.376982097923026 TNFAIP3/EGFR/RAC1 3 GO:0070664 negative regulation of leukocyte proliferation 3/308 90/18722 0.184891821502923 0.376982097923026 HLA-DRB1/CEBPB/TNFAIP3 3 GO:0043401 steroid hormone mediated signaling pathway 4/308 136/18722 0.18620404634204 0.379156805023207 YWHAH/PTGES3/DNAJA1/DDX5 4 GO:0002686 negative regulation of leukocyte migration 2/308 48/18722 0.186751834647842 0.379156805023207 DUSP1/PTGER4 2 GO:0032527 protein exit from endoplasmic reticulum 2/308 48/18722 0.186751834647842 0.379156805023207 HERPUD1/GCC2 2 GO:0045839 negative regulation of mitotic nuclear division 2/308 48/18722 0.186751834647842 0.379156805023207 DUSP1/IK 2 GO:0045912 negative regulation of carbohydrate metabolic process 2/308 48/18722 0.186751834647842 0.379156805023207 NUPR1/DDIT4 2 GO:0048146 positive regulation of fibroblast proliferation 2/308 48/18722 0.186751834647842 0.379156805023207 FN1/S100A6 2 GO:0090199 regulation of release of cytochrome c from mitochondria 2/308 48/18722 0.186751834647842 0.379156805023207 BID/TNFSF10 2 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2/308 48/18722 0.186751834647842 0.379156805023207 HSP90AB1/SDCBP 2 GO:0034765 regulation of ion transmembrane transport 11/308 491/18722 0.187636262768975 0.379822988689245 YWHAH/SNCA/TMSB4X/VAMP2/GLRX/SRI/C4orf3/FXYD3/CALM1/VMP1/CXCL10 11 GO:0000280 nuclear division 10/308 439/18722 0.188816118657438 0.379822988689245 DUSP1/CHMP1B/CHMP5/HSPA1A/UBE2B/IL1B/IK/HSPA1B/HNRNPU/UBB 10 GO:0050804 modulation of chemical synaptic transmission 10/308 439/18722 0.188816118657438 0.379822988689245 YWHAH/SNCA/SRGN/IL1B/VAMP2/PAIP2/RAB8A/EGFR/APOE/CALM1 10 GO:0019935 cyclic-nucleotide-mediated signaling 3/308 91/18722 0.18903862777923 0.379822988689245 UBE2B/APOE/DEFB1 3 GO:0042147 retrograde transport, endosome to Golgi 3/308 91/18722 0.18903862777923 0.379822988689245 SNX2/SNX3/GCC2 3 GO:0060048 cardiac muscle contraction 4/308 137/18722 0.189516004973174 0.379822988689245 CXCR4/SRI/DSP/CALM1 4 GO:0051896 regulation of protein kinase B signaling 5/308 185/18722 0.189903775973562 0.379822988689245 CCL3/KLF4/HSP90AB1/EGFR/HSP90AA1 5 GO:0099177 regulation of trans-synaptic signaling 10/308 440/18722 0.190603871810984 0.379822988689245 YWHAH/SNCA/SRGN/IL1B/VAMP2/PAIP2/RAB8A/EGFR/APOE/CALM1 10 GO:0006376 mRNA splice site selection 2/308 49/18722 0.192714211657904 0.379822988689245 SRSF5/SRSF9 2 GO:0014075 response to amine 2/308 49/18722 0.192714211657904 0.379822988689245 NR4A2/CALM1 2 GO:0030195 negative regulation of blood coagulation 2/308 49/18722 0.192714211657904 0.379822988689245 APOE/CD9 2 GO:0030857 negative regulation of epithelial cell differentiation 2/308 49/18722 0.192714211657904 0.379822988689245 STAT1/HES1 2 GO:0043457 regulation of cellular respiration 2/308 49/18722 0.192714211657904 0.379822988689245 SNCA/NUPR1 2 GO:0045778 positive regulation of ossification 2/308 49/18722 0.192714211657904 0.379822988689245 ISG15/FBN2 2 GO:0050832 defense response to fungus 2/308 49/18722 0.192714211657904 0.379822988689245 S100A8/S100A9 2 GO:0051445 regulation of meiotic cell cycle 2/308 49/18722 0.192714211657904 0.379822988689245 DUSP1/UBE2B 2 GO:1990928 response to amino acid starvation 2/308 49/18722 0.192714211657904 0.379822988689245 ATF3/EIF2AK2 2 GO:0071478 cellular response to radiation 5/308 186/18722 0.192736138934448 0.379822988689245 RHOB/EGR1/GRB2/NPM1/ADIRF 5 GO:0055076 transition metal ion homeostasis 4/308 138/18722 0.192846724441129 0.379822988689245 B2M/SRI/S100A8/S100A9 4 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 4/308 138/18722 0.192846724441129 0.379822988689245 NMI/NPM1/LAPTM5/UBB 4 GO:0001682 tRNA 5'-leader removal 1/308 13/18722 0.194034605521866 0.379822988689245 SSB 1 GO:0001833 inner cell mass cell proliferation 1/308 13/18722 0.194034605521866 0.379822988689245 SBDS 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/308 13/18722 0.194034605521866 0.379822988689245 STAT1 1 GO:0005513 detection of calcium ion 1/308 13/18722 0.194034605521866 0.379822988689245 CALM1 1 GO:0006000 fructose metabolic process 1/308 13/18722 0.194034605521866 0.379822988689245 ALDOA 1 GO:0006983 ER overload response 1/308 13/18722 0.194034605521866 0.379822988689245 BID 1 GO:0007494 midgut development 1/308 13/18722 0.194034605521866 0.379822988689245 EGFR 1 GO:0008298 intracellular mRNA localization 1/308 13/18722 0.194034605521866 0.379822988689245 ZFP36 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/308 13/18722 0.194034605521866 0.379822988689245 NFKBIA 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/308 13/18722 0.194034605521866 0.379822988689245 BNIP3L 1 GO:0010960 magnesium ion homeostasis 1/308 13/18722 0.194034605521866 0.379822988689245 EGFR 1 GO:0014745 negative regulation of muscle adaptation 1/308 13/18722 0.194034605521866 0.379822988689245 KLF4 1 GO:0016322 neuron remodeling 1/308 13/18722 0.194034605521866 0.379822988689245 C1QA 1 GO:0019336 phenol-containing compound catabolic process 1/308 13/18722 0.194034605521866 0.379822988689245 COMT 1 GO:0021984 adenohypophysis development 1/308 13/18722 0.194034605521866 0.379822988689245 HES1 1 GO:0032352 positive regulation of hormone metabolic process 1/308 13/18722 0.194034605521866 0.379822988689245 EGR1 1 GO:0033689 negative regulation of osteoblast proliferation 1/308 13/18722 0.194034605521866 0.379822988689245 EIF2AK2 1 GO:0034112 positive regulation of homotypic cell-cell adhesion 1/308 13/18722 0.194034605521866 0.379822988689245 LGALS1 1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 1/308 13/18722 0.194034605521866 0.379822988689245 TNFAIP3 1 GO:0035745 T-helper 2 cell cytokine production 1/308 13/18722 0.194034605521866 0.379822988689245 RSAD2 1 GO:0042541 hemoglobin biosynthetic process 1/308 13/18722 0.194034605521866 0.379822988689245 KLF4 1 GO:0042769 DNA damage response, detection of DNA damage 1/308 13/18722 0.194034605521866 0.379822988689245 DNAJA1 1 GO:0044794 positive regulation by host of viral process 1/308 13/18722 0.194034605521866 0.379822988689245 APOE 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/308 13/18722 0.194034605521866 0.379822988689245 NCF1 1 GO:0046512 sphingosine biosynthetic process 1/308 13/18722 0.194034605521866 0.379822988689245 ASAH1 1 GO:0046520 sphingoid biosynthetic process 1/308 13/18722 0.194034605521866 0.379822988689245 ASAH1 1 GO:0048012 hepatocyte growth factor receptor signaling pathway 1/308 13/18722 0.194034605521866 0.379822988689245 RAC1 1 GO:0048711 positive regulation of astrocyte differentiation 1/308 13/18722 0.194034605521866 0.379822988689245 HES1 1 GO:0051451 myoblast migration 1/308 13/18722 0.194034605521866 0.379822988689245 ANXA1 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/308 13/18722 0.194034605521866 0.379822988689245 HNRNPU 1 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/308 13/18722 0.194034605521866 0.379822988689245 ZFP36 1 GO:0060707 trophoblast giant cell differentiation 1/308 13/18722 0.194034605521866 0.379822988689245 SOCS3 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/308 13/18722 0.194034605521866 0.379822988689245 EGR1 1 GO:0061469 regulation of type B pancreatic cell proliferation 1/308 13/18722 0.194034605521866 0.379822988689245 NUPR1 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/308 13/18722 0.194034605521866 0.379822988689245 HK2 1 GO:0070254 mucus secretion 1/308 13/18722 0.194034605521866 0.379822988689245 EGFR 1 GO:0072578 neurotransmitter-gated ion channel clustering 1/308 13/18722 0.194034605521866 0.379822988689245 APOE 1 GO:0090042 tubulin deacetylation 1/308 13/18722 0.194034605521866 0.379822988689245 BEX4 1 GO:0090161 Golgi ribbon formation 1/308 13/18722 0.194034605521866 0.379822988689245 GCC2 1 GO:1900121 negative regulation of receptor binding 1/308 13/18722 0.194034605521866 0.379822988689245 B2M 1 GO:1900272 negative regulation of long-term synaptic potentiation 1/308 13/18722 0.194034605521866 0.379822988689245 APOE 1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1/308 13/18722 0.194034605521866 0.379822988689245 TMSB4X 1 GO:1903977 positive regulation of glial cell migration 1/308 13/18722 0.194034605521866 0.379822988689245 CCL3 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/308 13/18722 0.194034605521866 0.379822988689245 HK2 1 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/308 13/18722 0.194034605521866 0.379822988689245 KLF4 1 GO:1905907 negative regulation of amyloid fibril formation 1/308 13/18722 0.194034605521866 0.379822988689245 APOE 1 GO:1905939 regulation of gonad development 1/308 13/18722 0.194034605521866 0.379822988689245 NUPR1 1 GO:2000318 positive regulation of T-helper 17 type immune response 1/308 13/18722 0.194034605521866 0.379822988689245 NFKBIZ 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/308 13/18722 0.194034605521866 0.379822988689245 RSAD2 1 GO:2001023 regulation of response to drug 1/308 13/18722 0.194034605521866 0.379822988689245 ADIRF 1 GO:0000209 protein polyubiquitination 6/308 236/18722 0.194273617179926 0.379901809963609 UBE2B/TNFAIP3/NMI/TRIM22/UBE2L6/IFI27 6 GO:0048762 mesenchymal cell differentiation 6/308 236/18722 0.194273617179926 0.379901809963609 IL1B/STAT1/SDCBP/FN1/DDX5/HES1 6 GO:0001655 urogenital system development 8/308 338/18722 0.194862316156818 0.380858197682778 EGR1/BASP1/STAT1/SERPINF1/CTSH/FBN1/HES1/ANXA1 8 GO:0033044 regulation of chromosome organization 5/308 187/18722 0.195583434645037 0.382072289549298 DUSP1/HNRNPA1/IK/HNRNPU/PKIB 5 GO:0051783 regulation of nuclear division 4/308 139/18722 0.196195764698237 0.383072731583943 DUSP1/UBE2B/IL1B/IK 4 GO:0019318 hexose metabolic process 6/308 237/18722 0.19679091103269 0.384038618110247 PHLDA2/HK2/OAS1/ATF3/HMGB1/ALDOA 6 GO:0007589 body fluid secretion 3/308 93/18722 0.197402675337239 0.384447492518729 HK2/OAS2/EGFR 3 GO:0032755 positive regulation of interleukin-6 production 3/308 93/18722 0.197402675337239 0.384447492518729 IL1B/IFIH1/HMGB1 3 GO:0033273 response to vitamin 3/308 93/18722 0.197402675337239 0.384447492518729 SOD2/EGFR/CXCL10 3 GO:0060993 kidney morphogenesis 3/308 93/18722 0.197402675337239 0.384447492518729 BASP1/STAT1/HES1 3 GO:0016055 Wnt signaling pathway 10/308 444/18722 0.197830153722398 0.385083848106277 KLF4/UBE2B/TNFAIP3/EGR1/RPS12/EGFR/NR4A2/SNX3/RAC1/APOE 10 GO:0043628 ncRNA 3'-end processing 2/308 50/18722 0.198701062044209 0.385405459256727 SSB/LARP7 2 GO:0071825 protein-lipid complex subunit organization 2/308 50/18722 0.198701062044209 0.385405459256727 APOE/APOC1 2 GO:0099054 presynapse assembly 2/308 50/18722 0.198701062044209 0.385405459256727 SNCA/SDCBP 2 GO:1900047 negative regulation of hemostasis 2/308 50/18722 0.198701062044209 0.385405459256727 APOE/CD9 2 GO:1902930 regulation of alcohol biosynthetic process 2/308 50/18722 0.198701062044209 0.385405459256727 SNCA/APOE 2 GO:1903747 regulation of establishment of protein localization to mitochondrion 2/308 50/18722 0.198701062044209 0.385405459256727 BNIP3L/DNAJA1 2 GO:1904036 negative regulation of epithelial cell apoptotic process 2/308 50/18722 0.198701062044209 0.385405459256727 NUPR1/TNFAIP3 2 GO:0051259 protein complex oligomerization 6/308 238/18722 0.199320444094814 0.386292731964138 B2M/HLA-DRB1/SNCA/ISG15/SOD2/ALDOA 6 GO:0030177 positive regulation of Wnt signaling pathway 4/308 140/18722 0.199562685228661 0.386292731964138 UBE2B/TNFAIP3/RPS12/EGFR 4 GO:0046165 alcohol biosynthetic process 4/308 140/18722 0.199562685228661 0.386292731964138 SNCA/ISYNA1/APOE/ASAH1 4 GO:0050768 negative regulation of neurogenesis 4/308 140/18722 0.199562685228661 0.386292731964138 B2M/YWHAH/IL1B/HES1 4 GO:0009060 aerobic respiration 5/308 189/18722 0.201321782310358 0.386594709405351 SNCA/NUPR1/SDHD/BID/UQCR11 5 GO:0198738 cell-cell signaling by wnt 10/308 446/18722 0.201487674706394 0.386594709405351 KLF4/UBE2B/TNFAIP3/EGR1/RPS12/EGFR/NR4A2/SNX3/RAC1/APOE 10 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 3/308 94/18722 0.20161813940926 0.386594709405351 TNFAIP3/HERC5/EGFR 3 GO:0032091 negative regulation of protein binding 3/308 94/18722 0.20161813940926 0.386594709405351 B2M/IFIT1/IFIT2 3 GO:1902414 protein localization to cell junction 3/308 94/18722 0.20161813940926 0.386594709405351 VAMP2/RAB8A/DSP 3 GO:0034504 protein localization to nucleus 7/308 290/18722 0.202351887553036 0.386594709405351 NFKBIA/HSP90AB1/LARP7/DNAJB6/NPM1/HNRNPU/TXNIP 7 GO:0008584 male gonad development 4/308 141/18722 0.202947045214313 0.386594709405351 HMGB2/NUPR1/TNFSF10/UBB 4 GO:0046390 ribose phosphate biosynthetic process 5/308 190/18722 0.204212310371138 0.386594709405351 SNCA/TMSB4X/MPC2/TKT/ALDOA 5 GO:0060485 mesenchyme development 7/308 291/18722 0.204660028525702 0.386594709405351 IL1B/BASP1/STAT1/SDCBP/FN1/DDX5/HES1 7 GO:0010874 regulation of cholesterol efflux 2/308 51/18722 0.204709977182606 0.386594709405351 NFKBIA/APOE 2 GO:0032873 negative regulation of stress-activated MAPK cascade 2/308 51/18722 0.204709977182606 0.386594709405351 DUSP1/DNAJA1 2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 2/308 51/18722 0.204709977182606 0.386594709405351 TNFAIP3/STAT1 2 GO:0045104 intermediate filament cytoskeleton organization 2/308 51/18722 0.204709977182606 0.386594709405351 DSP/DNAJB6 2 GO:0045661 regulation of myoblast differentiation 2/308 51/18722 0.204709977182606 0.386594709405351 BTG1/CXCL10 2 GO:0046850 regulation of bone remodeling 2/308 51/18722 0.204709977182606 0.386594709405351 TNFAIP3/EGFR 2 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 2/308 51/18722 0.204709977182606 0.386594709405351 DUSP1/DNAJA1 2 GO:0071622 regulation of granulocyte chemotaxis 2/308 51/18722 0.204709977182606 0.386594709405351 CXCL8/RAC1 2 GO:0006942 regulation of striated muscle contraction 3/308 95/18722 0.205854722912597 0.386594709405351 SRI/DSP/CALM1 3 GO:0008585 female gonad development 3/308 95/18722 0.205854722912597 0.386594709405351 CEBPB/NUPR1/UBB 3 GO:0048709 oligodendrocyte differentiation 3/308 95/18722 0.205854722912597 0.386594709405351 CXCR4/CD9/HES1 3 GO:0007009 plasma membrane organization 4/308 142/18722 0.206348403697048 0.386594709405351 PLSCR1/CXCR4/CD9/S100A9 4 GO:0046546 development of primary male sexual characteristics 4/308 142/18722 0.206348403697048 0.386594709405351 HMGB2/NUPR1/TNFSF10/UBB 4 GO:0072006 nephron development 4/308 142/18722 0.206348403697048 0.386594709405351 EGR1/BASP1/STAT1/HES1 4 GO:0019693 ribose phosphate metabolic process 9/308 396/18722 0.206765321557661 0.386594709405351 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/TKT/LDHA/ALDOA 9 GO:0044843 cell cycle G1/S phase transition 6/308 241/18722 0.206980743904786 0.386594709405351 KLF4/BID/EGFR/PSME2/RPS27L/ANXA1 6 GO:0001921 positive regulation of receptor recycling 1/308 14/18722 0.207302943834938 0.386594709405351 SNCA 1 GO:0002091 negative regulation of receptor internalization 1/308 14/18722 0.207302943834938 0.386594709405351 SDCBP 1 GO:0002517 T cell tolerance induction 1/308 14/18722 0.207302943834938 0.386594709405351 HLA-B 1 GO:0002829 negative regulation of type 2 immune response 1/308 14/18722 0.207302943834938 0.386594709405351 ANXA1 1 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/308 14/18722 0.207302943834938 0.386594709405351 RAC1 1 GO:0006465 signal peptide processing 1/308 14/18722 0.207302943834938 0.386594709405351 SEC11A 1 GO:0006521 regulation of cellular amino acid metabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 COMT 1 GO:0009159 deoxyribonucleoside monophosphate catabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 TYMP 1 GO:0018158 protein oxidation 1/308 14/18722 0.207302943834938 0.386594709405351 PRDX3 1 GO:0030213 hyaluronan biosynthetic process 1/308 14/18722 0.207302943834938 0.386594709405351 IL1B 1 GO:0031115 negative regulation of microtubule polymerization 1/308 14/18722 0.207302943834938 0.386594709405351 SNCA 1 GO:0031650 regulation of heat generation 1/308 14/18722 0.207302943834938 0.386594709405351 IL1B 1 GO:0032688 negative regulation of interferon-beta production 1/308 14/18722 0.207302943834938 0.386594709405351 NMI 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/308 14/18722 0.207302943834938 0.386594709405351 CD9 1 GO:0035641 locomotory exploration behavior 1/308 14/18722 0.207302943834938 0.386594709405351 APOE 1 GO:0042415 norepinephrine metabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 LY6E 1 GO:0043144 sno(s)RNA processing 1/308 14/18722 0.207302943834938 0.386594709405351 LARP7 1 GO:0043249 erythrocyte maturation 1/308 14/18722 0.207302943834938 0.386594709405351 KLF2 1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1/308 14/18722 0.207302943834938 0.386594709405351 DDX5 1 GO:0043951 negative regulation of cAMP-mediated signaling 1/308 14/18722 0.207302943834938 0.386594709405351 UBE2B 1 GO:0045006 DNA deamination 1/308 14/18722 0.207302943834938 0.386594709405351 APOBEC3A 1 GO:0045837 negative regulation of membrane potential 1/308 14/18722 0.207302943834938 0.386594709405351 BNIP3L 1 GO:0046131 pyrimidine ribonucleoside metabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 APOBEC3A 1 GO:0046133 pyrimidine ribonucleoside catabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 APOBEC3A 1 GO:0048148 behavioral response to cocaine 1/308 14/18722 0.207302943834938 0.386594709405351 SNCA 1 GO:0050667 homocysteine metabolic process 1/308 14/18722 0.207302943834938 0.386594709405351 COMT 1 GO:0050930 induction of positive chemotaxis 1/308 14/18722 0.207302943834938 0.386594709405351 CXCL8 1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 1/308 14/18722 0.207302943834938 0.386594709405351 CXCR4 1 GO:0051589 negative regulation of neurotransmitter transport 1/308 14/18722 0.207302943834938 0.386594709405351 SNCA 1 GO:0051764 actin crosslink formation 1/308 14/18722 0.207302943834938 0.386594709405351 MARCKS 1 GO:0051984 positive regulation of chromosome segregation 1/308 14/18722 0.207302943834938 0.386594709405351 HNRNPU 1 GO:0060354 negative regulation of cell adhesion molecule production 1/308 14/18722 0.207302943834938 0.386594709405351 CXCL8 1 GO:0060732 positive regulation of inositol phosphate biosynthetic process 1/308 14/18722 0.207302943834938 0.386594709405351 SNCA 1 GO:0070141 response to UV-A 1/308 14/18722 0.207302943834938 0.386594709405351 EGFR 1 GO:0072160 nephron tubule epithelial cell differentiation 1/308 14/18722 0.207302943834938 0.386594709405351 STAT1 1 GO:0099638 endosome to plasma membrane protein transport 1/308 14/18722 0.207302943834938 0.386594709405351 RAB8A 1 GO:1901077 regulation of relaxation of muscle 1/308 14/18722 0.207302943834938 0.386594709405351 SRI 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/308 14/18722 0.207302943834938 0.386594709405351 EGR1 1 GO:1901857 positive regulation of cellular respiration 1/308 14/18722 0.207302943834938 0.386594709405351 NUPR1 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/308 14/18722 0.207302943834938 0.386594709405351 EIF2AK2 1 GO:1902916 positive regulation of protein polyubiquitination 1/308 14/18722 0.207302943834938 0.386594709405351 NMI 1 GO:1904294 positive regulation of ERAD pathway 1/308 14/18722 0.207302943834938 0.386594709405351 HERPUD1 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/308 14/18722 0.207302943834938 0.386594709405351 HK2 1 GO:1905049 negative regulation of metallopeptidase activity 1/308 14/18722 0.207302943834938 0.386594709405351 TIMP3 1 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 1/308 14/18722 0.207302943834938 0.386594709405351 SOD2 1 GO:1905208 negative regulation of cardiocyte differentiation 1/308 14/18722 0.207302943834938 0.386594709405351 EGFR 1 GO:1990173 protein localization to nucleoplasm 1/308 14/18722 0.207302943834938 0.386594709405351 LARP7 1 GO:2001140 positive regulation of phospholipid transport 1/308 14/18722 0.207302943834938 0.386594709405351 APOE 1 GO:2001171 positive regulation of ATP biosynthetic process 1/308 14/18722 0.207302943834938 0.386594709405351 TMSB4X 1 GO:2001256 regulation of store-operated calcium entry 1/308 14/18722 0.207302943834938 0.386594709405351 SARAF 1 GO:0001822 kidney development 7/308 293/18722 0.209306497349243 0.390140779798224 EGR1/BASP1/STAT1/SERPINF1/CTSH/FBN1/HES1 7 GO:0031023 microtubule organizing center organization 4/308 143/18722 0.209766319737165 0.390336117496619 CHMP1B/CHMP5/NPM1/GCC2 4 GO:0015914 phospholipid transport 3/308 96/18722 0.210111553747287 0.390336117496619 PLSCR1/APOE/APOC1 3 GO:0044264 cellular polysaccharide metabolic process 3/308 96/18722 0.210111553747287 0.390336117496619 PHLDA2/PTGES3/HMGB1 3 GO:0051304 chromosome separation 3/308 96/18722 0.210111553747287 0.390336117496619 PLSCR1/DUSP1/IK 3 GO:1904035 regulation of epithelial cell apoptotic process 3/308 96/18722 0.210111553747287 0.390336117496619 ZFP36/NUPR1/TNFAIP3 3 GO:0002218 activation of innate immune response 2/308 52/18722 0.210738620589334 0.390336117496619 HMGB1/HSP90AA1 2 GO:0010718 positive regulation of epithelial to mesenchymal transition 2/308 52/18722 0.210738620589334 0.390336117496619 IL1B/SDCBP 2 GO:0021545 cranial nerve development 2/308 52/18722 0.210738620589334 0.390336117496619 MAFB/HES1 2 GO:0032206 positive regulation of telomere maintenance 2/308 52/18722 0.210738620589334 0.390336117496619 HNRNPA1/PKIB 2 GO:0035196 production of miRNAs involved in gene silencing by miRNA 2/308 52/18722 0.210738620589334 0.390336117496619 EGFR/DDX5 2 GO:0045010 actin nucleation 2/308 52/18722 0.210738620589334 0.390336117496619 ARPC3/IQGAP2 2 GO:0045103 intermediate filament-based process 2/308 52/18722 0.210738620589334 0.390336117496619 DSP/DNAJB6 2 GO:1903426 regulation of reactive oxygen species biosynthetic process 2/308 52/18722 0.210738620589334 0.390336117496619 SNCA/SOD2 2 GO:0007059 chromosome segregation 8/308 346/18722 0.21180060316264 0.392113174765508 PLSCR1/DUSP1/CHMP1B/CHMP5/UBE2B/BEX4/IK/HNRNPU 8 GO:0014065 phosphatidylinositol 3-kinase signaling 4/308 144/18722 0.213200352568218 0.394513527525798 KLF4/NCF1/EGFR/FN1 4 GO:0048193 Golgi vesicle transport 7/308 296/18722 0.21634976948095 0.396242526847969 GABARAPL2/VAMP2/RAB8A/SNX2/SNX3/GCC2/LAPTM5 7 GO:0051961 negative regulation of nervous system development 4/308 145/18722 0.216650061748172 0.396242526847969 B2M/YWHAH/IL1B/HES1 4 GO:0032784 regulation of DNA-templated transcription, elongation 2/308 53/18722 0.216784726212384 0.396242526847969 LARP7/HNRNPU 2 GO:0034381 plasma lipoprotein particle clearance 2/308 53/18722 0.216784726212384 0.396242526847969 APOE/APOC1 2 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/308 53/18722 0.216784726212384 0.396242526847969 SNCA/CXCL8 2 GO:0050819 negative regulation of coagulation 2/308 53/18722 0.216784726212384 0.396242526847969 APOE/CD9 2 GO:0051438 regulation of ubiquitin-protein transferase activity 2/308 53/18722 0.216784726212384 0.396242526847969 RPL37/RPS15 2 GO:0071715 icosanoid transport 2/308 53/18722 0.216784726212384 0.396242526847969 IL1B/ANXA1 2 GO:0099172 presynapse organization 2/308 53/18722 0.216784726212384 0.396242526847969 SNCA/SDCBP 2 GO:0017148 negative regulation of translation 6/308 245/18722 0.217355216903516 0.396242526847969 NCL/ZFP36/PAIP2/EIF2AK2/CIRBP/EIF3E 6 GO:0061337 cardiac conduction 3/308 98/18722 0.218682504817242 0.396242526847969 SRI/DSP/CALM1 3 GO:0002679 respiratory burst involved in defense response 1/308 15/18722 0.220353547496412 0.396242526847969 NCF1 1 GO:0002730 regulation of dendritic cell cytokine production 1/308 15/18722 0.220353547496412 0.396242526847969 BST2 1 GO:0002836 positive regulation of response to tumor cell 1/308 15/18722 0.220353547496412 0.396242526847969 HLA-DRB1 1 GO:0002839 positive regulation of immune response to tumor cell 1/308 15/18722 0.220353547496412 0.396242526847969 HLA-DRB1 1 GO:0006089 lactate metabolic process 1/308 15/18722 0.220353547496412 0.396242526847969 LDHA 1 GO:0006098 pentose-phosphate shunt 1/308 15/18722 0.220353547496412 0.396242526847969 TKT 1 GO:0010832 negative regulation of myotube differentiation 1/308 15/18722 0.220353547496412 0.396242526847969 BHLHE41 1 GO:0010889 regulation of sequestering of triglyceride 1/308 15/18722 0.220353547496412 0.396242526847969 PLIN2 1 GO:0014048 regulation of glutamate secretion 1/308 15/18722 0.220353547496412 0.396242526847969 SNCA 1 GO:0018216 peptidyl-arginine methylation 1/308 15/18722 0.220353547496412 0.396242526847969 PRMT9 1 GO:0019511 peptidyl-proline hydroxylation 1/308 15/18722 0.220353547496412 0.396242526847969 P4HA1 1 GO:0023035 CD40 signaling pathway 1/308 15/18722 0.220353547496412 0.396242526847969 TNFAIP3 1 GO:0032310 prostaglandin secretion 1/308 15/18722 0.220353547496412 0.396242526847969 IL1B 1 GO:0032488 Cdc42 protein signal transduction 1/308 15/18722 0.220353547496412 0.396242526847969 APOE 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/308 15/18722 0.220353547496412 0.396242526847969 IL1B 1 GO:0034310 primary alcohol catabolic process 1/308 15/18722 0.220353547496412 0.396242526847969 ALDH2 1 GO:0034380 high-density lipoprotein particle assembly 1/308 15/18722 0.220353547496412 0.396242526847969 APOE 1 GO:0034384 high-density lipoprotein particle clearance 1/308 15/18722 0.220353547496412 0.396242526847969 APOE 1 GO:0034638 phosphatidylcholine catabolic process 1/308 15/18722 0.220353547496412 0.396242526847969 APOC1 1 GO:0042159 lipoprotein catabolic process 1/308 15/18722 0.220353547496412 0.396242526847969 APOE 1 GO:0043508 negative regulation of JUN kinase activity 1/308 15/18722 0.220353547496412 0.396242526847969 DNAJA1 1 GO:0044406 adhesion of symbiont to host 1/308 15/18722 0.220353547496412 0.396242526847969 HSP90AB1 1 GO:0045064 T-helper 2 cell differentiation 1/308 15/18722 0.220353547496412 0.396242526847969 ANXA1 1 GO:0045475 locomotor rhythm 1/308 15/18722 0.220353547496412 0.396242526847969 EGR1 1 GO:0045836 positive regulation of meiotic nuclear division 1/308 15/18722 0.220353547496412 0.396242526847969 UBE2B 1 GO:0046184 aldehyde biosynthetic process 1/308 15/18722 0.220353547496412 0.396242526847969 TKT 1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 1/308 15/18722 0.220353547496412 0.396242526847969 HNRNPU 1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/308 15/18722 0.220353547496412 0.396242526847969 ZFP36 1 GO:0060253 negative regulation of glial cell proliferation 1/308 15/18722 0.220353547496412 0.396242526847969 HES1 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/308 15/18722 0.220353547496412 0.396242526847969 CAMTA1 1 GO:0071380 cellular response to prostaglandin E stimulus 1/308 15/18722 0.220353547496412 0.396242526847969 PTGER4 1 GO:0071871 response to epinephrine 1/308 15/18722 0.220353547496412 0.396242526847969 SNCA 1 GO:0072224 metanephric glomerulus development 1/308 15/18722 0.220353547496412 0.396242526847969 EGR1 1 GO:0086069 bundle of His cell to Purkinje myocyte communication 1/308 15/18722 0.220353547496412 0.396242526847969 DSP 1 GO:0098760 response to interleukin-7 1/308 15/18722 0.220353547496412 0.396242526847969 HMGB1 1 GO:0098761 cellular response to interleukin-7 1/308 15/18722 0.220353547496412 0.396242526847969 HMGB1 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/308 15/18722 0.220353547496412 0.396242526847969 CAMTA1 1 GO:0110156 methylguanosine-cap decapping 1/308 15/18722 0.220353547496412 0.396242526847969 ZFP36 1 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 1/308 15/18722 0.220353547496412 0.396242526847969 PPP1R15A 1 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/308 15/18722 0.220353547496412 0.396242526847969 ZFP36 1 GO:1901660 calcium ion export 1/308 15/18722 0.220353547496412 0.396242526847969 CALM1 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/308 15/18722 0.220353547496412 0.396242526847969 NCL 1 GO:1902902 negative regulation of autophagosome assembly 1/308 15/18722 0.220353547496412 0.396242526847969 NUPR1 1 GO:1903543 positive regulation of exosomal secretion 1/308 15/18722 0.220353547496412 0.396242526847969 SDCBP 1 GO:1905288 vascular associated smooth muscle cell apoptotic process 1/308 15/18722 0.220353547496412 0.396242526847969 SOD2 1 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 1/308 15/18722 0.220353547496412 0.396242526847969 SOD2 1 GO:2000345 regulation of hepatocyte proliferation 1/308 15/18722 0.220353547496412 0.396242526847969 TNFAIP3 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/308 15/18722 0.220353547496412 0.396242526847969 TMSB4X 1 GO:2001138 regulation of phospholipid transport 1/308 15/18722 0.220353547496412 0.396242526847969 APOE 1 GO:0006006 glucose metabolic process 5/308 196/18722 0.221837781318174 0.398723948274274 PHLDA2/HK2/OAS1/ATF3/HMGB1 5 GO:0031050 dsRNA processing 2/308 54/18722 0.222846096759271 0.400159994321602 EGFR/DDX5 2 GO:0070918 production of small RNA involved in gene silencing by RNA 2/308 54/18722 0.222846096759271 0.400159994321602 EGFR/DDX5 2 GO:0030838 positive regulation of actin filament polymerization 3/308 99/18722 0.222994917419689 0.40023923441102 GRB2/ARPC3/IQGAP2 3 GO:0042254 ribosome biogenesis 7/308 299/18722 0.223478244322709 0.400918502133137 RPS28/SBDS/RPS27/NPM1/RPL3/RPS27L/RPS15 7 GO:0044839 cell cycle G2/M phase transition 4/308 148/18722 0.227088850899829 0.404668763636205 ENSA/SYF2/NPM1/CALM1 4 GO:0006626 protein targeting to mitochondrion 3/308 100/18722 0.227324162561691 0.404668763636205 BNIP3L/BID/HSP90AA1 3 GO:0045807 positive regulation of endocytosis 3/308 100/18722 0.227324162561691 0.404668763636205 B2M/SNCA/APOE 3 GO:0046545 development of primary female sexual characteristics 3/308 100/18722 0.227324162561691 0.404668763636205 CEBPB/NUPR1/UBB 3 GO:0061640 cytoskeleton-dependent cytokinesis 3/308 100/18722 0.227324162561691 0.404668763636205 CHMP1B/CHMP5/RHOB 3 GO:0000768 syncytium formation by plasma membrane fusion 2/308 55/18722 0.228920602060467 0.404668763636205 CD9/CXCL10 2 GO:0003229 ventricular cardiac muscle tissue development 2/308 55/18722 0.228920602060467 0.404668763636205 LY6E/DSP 2 GO:0008333 endosome to lysosome transport 2/308 55/18722 0.228920602060467 0.404668763636205 CHMP5/RHOB 2 GO:0010676 positive regulation of cellular carbohydrate metabolic process 2/308 55/18722 0.228920602060467 0.404668763636205 SNCA/HMGB1 2 GO:0042220 response to cocaine 2/308 55/18722 0.228920602060467 0.404668763636205 SNCA/HSP90AB1 2 GO:0045620 negative regulation of lymphocyte differentiation 2/308 55/18722 0.228920602060467 0.404668763636205 HMGB1/ANXA1 2 GO:0046164 alcohol catabolic process 2/308 55/18722 0.228920602060467 0.404668763636205 ALDH2/APOE 2 GO:0098900 regulation of action potential 2/308 55/18722 0.228920602060467 0.404668763636205 DSP/CALM1 2 GO:0140253 cell-cell fusion 2/308 55/18722 0.228920602060467 0.404668763636205 CD9/CXCL10 2 GO:1905517 macrophage migration 2/308 55/18722 0.228920602060467 0.404668763636205 CCL3/CD9 2 GO:0009411 response to UV 4/308 149/18722 0.23059687263063 0.404668763636205 UBE2B/CIRBP/EGFR/NPM1 4 GO:0032368 regulation of lipid transport 4/308 149/18722 0.23059687263063 0.404668763636205 NFKBIA/IL1B/APOE/APOC1 4 GO:0045834 positive regulation of lipid metabolic process 4/308 149/18722 0.23059687263063 0.404668763636205 IL1B/APOE/ANXA1/APOC1 4 GO:0072001 renal system development 7/308 302/18722 0.23068840295767 0.404668763636205 EGR1/BASP1/STAT1/SERPINF1/CTSH/FBN1/HES1 7 GO:0060070 canonical Wnt signaling pathway 7/308 303/18722 0.233109325177113 0.404668763636205 KLF4/UBE2B/EGR1/RPS12/EGFR/NR4A2/APOE 7 GO:0006325 chromatin organization 9/308 409/18722 0.233148530798101 0.404668763636205 HMGB2/ANP32E/ANP32B/CHD2/SET/NPM1/HMGB1/HNRNPU/NAP1L1 9 GO:0001732 formation of cytoplasmic translation initiation complex 1/308 16/18722 0.23318997810373 0.404668763636205 EIF3E 1 GO:0002371 dendritic cell cytokine production 1/308 16/18722 0.23318997810373 0.404668763636205 BST2 1 GO:0002827 positive regulation of T-helper 1 type immune response 1/308 16/18722 0.23318997810373 0.404668763636205 IL1B 1 GO:0002830 positive regulation of type 2 immune response 1/308 16/18722 0.23318997810373 0.404668763636205 RSAD2 1 GO:0005980 glycogen catabolic process 1/308 16/18722 0.23318997810373 0.404668763636205 HMGB1 1 GO:0006206 pyrimidine nucleobase metabolic process 1/308 16/18722 0.23318997810373 0.404668763636205 TYMP 1 GO:0006266 DNA ligation 1/308 16/18722 0.23318997810373 0.404668763636205 HMGB1 1 GO:0006555 methionine metabolic process 1/308 16/18722 0.23318997810373 0.404668763636205 SMS 1 GO:0006740 NADPH regeneration 1/308 16/18722 0.23318997810373 0.404668763636205 TKT 1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1/308 16/18722 0.23318997810373 0.404668763636205 RPS27L 1 GO:0009299 mRNA transcription 1/308 16/18722 0.23318997810373 0.404668763636205 DDX5 1 GO:0010819 regulation of T cell chemotaxis 1/308 16/18722 0.23318997810373 0.404668763636205 CXCL10 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/308 16/18722 0.23318997810373 0.404668763636205 SNCA 1 GO:0016074 sno(s)RNA metabolic process 1/308 16/18722 0.23318997810373 0.404668763636205 LARP7 1 GO:0019081 viral translation 1/308 16/18722 0.23318997810373 0.404668763636205 SSB 1 GO:0021783 preganglionic parasympathetic fiber development 1/308 16/18722 0.23318997810373 0.404668763636205 HES1 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 1/308 16/18722 0.23318997810373 0.404668763636205 IL1B 1 GO:0033631 cell-cell adhesion mediated by integrin 1/308 16/18722 0.23318997810373 0.404668763636205 SWAP70 1 GO:0034116 positive regulation of heterotypic cell-cell adhesion 1/308 16/18722 0.23318997810373 0.404668763636205 IL1B 1 GO:0034374 low-density lipoprotein particle remodeling 1/308 16/18722 0.23318997810373 0.404668763636205 APOE 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/308 16/18722 0.23318997810373 0.404668763636205 SOD2 1 GO:0035970 peptidyl-threonine dephosphorylation 1/308 16/18722 0.23318997810373 0.404668763636205 DUSP1 1 GO:0042795 snRNA transcription by RNA polymerase II 1/308 16/18722 0.23318997810373 0.404668763636205 LARP7 1 GO:0043923 positive regulation by host of viral transcription 1/308 16/18722 0.23318997810373 0.404668763636205 JUN 1 GO:0044849 estrous cycle 1/308 16/18722 0.23318997810373 0.404668763636205 EGR1 1 GO:0045651 positive regulation of macrophage differentiation 1/308 16/18722 0.23318997810373 0.404668763636205 TRIB1 1 GO:0045779 negative regulation of bone resorption 1/308 16/18722 0.23318997810373 0.404668763636205 TNFAIP3 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/308 16/18722 0.23318997810373 0.404668763636205 APOBEC3A 1 GO:0046135 pyrimidine nucleoside catabolic process 1/308 16/18722 0.23318997810373 0.404668763636205 APOBEC3A 1 GO:0048385 regulation of retinoic acid receptor signaling pathway 1/308 16/18722 0.23318997810373 0.404668763636205 KLF2 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/308 16/18722 0.23318997810373 0.404668763636205 CXCR4 1 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 1/308 16/18722 0.23318997810373 0.404668763636205 STAT1 1 GO:0051969 regulation of transmission of nerve impulse 1/308 16/18722 0.23318997810373 0.404668763636205 TYMP 1 GO:0055089 fatty acid homeostasis 1/308 16/18722 0.23318997810373 0.404668763636205 APOE 1 GO:0060330 regulation of response to interferon-gamma 1/308 16/18722 0.23318997810373 0.404668763636205 HSP90AB1 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/308 16/18722 0.23318997810373 0.404668763636205 HSP90AB1 1 GO:0070365 hepatocyte differentiation 1/308 16/18722 0.23318997810373 0.404668763636205 ANXA1 1 GO:0071361 cellular response to ethanol 1/308 16/18722 0.23318997810373 0.404668763636205 SOD2 1 GO:0072109 glomerular mesangium development 1/308 16/18722 0.23318997810373 0.404668763636205 EGR1 1 GO:0072283 metanephric renal vesicle morphogenesis 1/308 16/18722 0.23318997810373 0.404668763636205 STAT1 1 GO:0090231 regulation of spindle checkpoint 1/308 16/18722 0.23318997810373 0.404668763636205 DUSP1 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/308 16/18722 0.23318997810373 0.404668763636205 DUSP1 1 GO:0090520 sphingolipid mediated signaling pathway 1/308 16/18722 0.23318997810373 0.404668763636205 RAC1 1 GO:0099116 tRNA 5'-end processing 1/308 16/18722 0.23318997810373 0.404668763636205 SSB 1 GO:1902570 protein localization to nucleolus 1/308 16/18722 0.23318997810373 0.404668763636205 NPM1 1 GO:1902931 negative regulation of alcohol biosynthetic process 1/308 16/18722 0.23318997810373 0.404668763636205 APOE 1 GO:1903504 regulation of mitotic spindle checkpoint 1/308 16/18722 0.23318997810373 0.404668763636205 DUSP1 1 GO:1904683 regulation of metalloendopeptidase activity 1/308 16/18722 0.23318997810373 0.404668763636205 TIMP3 1 GO:1904948 midbrain dopaminergic neuron differentiation 1/308 16/18722 0.23318997810373 0.404668763636205 NR4A2 1 GO:1905906 regulation of amyloid fibril formation 1/308 16/18722 0.23318997810373 0.404668763636205 APOE 1 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 1/308 16/18722 0.23318997810373 0.404668763636205 GLRX 1 GO:0071902 positive regulation of protein serine/threonine kinase activity 5/308 200/18722 0.233837385972567 0.405608133653868 SNCA/IL1B/HSP90AB1/EGFR/CALM1 5 GO:0010332 response to gamma radiation 2/308 56/18722 0.23500617746779 0.406897018323987 EGR1/CXCL10 2 GO:0048008 platelet-derived growth factor receptor signaling pathway 2/308 56/18722 0.23500617746779 0.406897018323987 SNCA/TXNIP 2 GO:0051784 negative regulation of nuclear division 2/308 56/18722 0.23500617746779 0.406897018323987 DUSP1/IK 2 GO:0098781 ncRNA transcription 2/308 56/18722 0.23500617746779 0.406897018323987 NCL/LARP7 2 GO:0090287 regulation of cellular response to growth factor stimulus 7/308 304/18722 0.235538793400779 0.407634589031768 FBN2/HSPA1A/IL1B/HSP90AB1/SDCBP/FBN1/HES1 7 GO:0045833 negative regulation of lipid metabolic process 3/308 102/18722 0.236029822284103 0.40811488493538 IL1B/APOE/APOC1 3 GO:1904063 negative regulation of cation transmembrane transport 3/308 102/18722 0.236029822284103 0.40811488493538 SRI/C4orf3/CALM1 3 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 9/308 412/18722 0.23940730307852 0.413767685203066 HSPA1A/UBE2B/HSP90AB1/IFI27/TRIB1/HERPUD1/SDCBP/SUMO2/HSPA1B 9 GO:0000819 sister chromatid segregation 5/308 202/18722 0.239905529988859 0.414254219127104 DUSP1/CHMP1B/CHMP5/IK/HNRNPU 5 GO:0032388 positive regulation of intracellular transport 5/308 202/18722 0.239905529988859 0.414254219127104 ANP32B/IL1B/VAMP2/HSP90AB1/OAZ1 5 GO:0002027 regulation of heart rate 3/308 103/18722 0.24040459361852 0.414741318322925 SRI/DSP/CALM1 3 GO:0019233 sensory perception of pain 3/308 103/18722 0.24040459361852 0.414741318322925 CCL3/COMT/CXCR4 3 GO:0006754 ATP biosynthetic process 2/308 57/18722 0.241100822287047 0.414803413015722 TMSB4X/ALDOA 2 GO:0006949 syncytium formation 2/308 57/18722 0.241100822287047 0.414803413015722 CD9/CXCL10 2 GO:0051205 protein insertion into membrane 2/308 57/18722 0.241100822287047 0.414803413015722 EGFR/HSP90AA1 2 GO:0051785 positive regulation of nuclear division 2/308 57/18722 0.241100822287047 0.414803413015722 UBE2B/IL1B 2 GO:0097120 receptor localization to synapse 2/308 57/18722 0.241100822287047 0.414803413015722 VAMP2/RAB8A 2 GO:0030509 BMP signaling pathway 4/308 152/18722 0.241200101264439 0.414803413015722 EGR1/DDX5/FBN1/HES1 4 GO:0031056 regulation of histone modification 4/308 152/18722 0.241200101264439 0.414803413015722 SNCA/UBE2B/IL1B/SET 4 GO:0006338 chromatin remodeling 6/308 255/18722 0.244023863647592 0.414902238806019 HMGB2/ANP32E/ANP32B/SET/NPM1/NAP1L1 6 GO:0048661 positive regulation of smooth muscle cell proliferation 3/308 104/18722 0.244792911369368 0.414902238806019 JUN/EGFR/STAT1 3 GO:0006909 phagocytosis 7/308 308/18722 0.245339437885753 0.414902238806019 PLSCR1/IRF8/IL1B/SNX3/RAC1/HMGB1/ANXA1 7 GO:0001710 mesodermal cell fate commitment 1/308 17/18722 0.245815739182745 0.414902238806019 KLF4 1 GO:0001829 trophectodermal cell differentiation 1/308 17/18722 0.245815739182745 0.414902238806019 JUNB 1 GO:0007351 tripartite regional subdivision 1/308 17/18722 0.245815739182745 0.414902238806019 BASP1 1 GO:0007379 segment specification 1/308 17/18722 0.245815739182745 0.414902238806019 MAFB 1 GO:0008334 histone mRNA metabolic process 1/308 17/18722 0.245815739182745 0.414902238806019 SSB 1 GO:0008595 anterior/posterior axis specification, embryo 1/308 17/18722 0.245815739182745 0.414902238806019 BASP1 1 GO:0009251 glucan catabolic process 1/308 17/18722 0.245815739182745 0.414902238806019 HMGB1 1 GO:0010566 regulation of ketone biosynthetic process 1/308 17/18722 0.245815739182745 0.414902238806019 EGR1 1 GO:0010934 macrophage cytokine production 1/308 17/18722 0.245815739182745 0.414902238806019 LAPTM5 1 GO:0010935 regulation of macrophage cytokine production 1/308 17/18722 0.245815739182745 0.414902238806019 LAPTM5 1 GO:0016264 gap junction assembly 1/308 17/18722 0.245815739182745 0.414902238806019 IL1B 1 GO:0020027 hemoglobin metabolic process 1/308 17/18722 0.245815739182745 0.414902238806019 KLF4 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/308 17/18722 0.245815739182745 0.414902238806019 CHMP5 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/308 17/18722 0.245815739182745 0.414902238806019 IL1B 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/308 17/18722 0.245815739182745 0.414902238806019 IL1B 1 GO:0033623 regulation of integrin activation 1/308 17/18722 0.245815739182745 0.414902238806019 PTGER4 1 GO:0034349 glial cell apoptotic process 1/308 17/18722 0.245815739182745 0.414902238806019 BID 1 GO:0036035 osteoclast development 1/308 17/18722 0.245815739182745 0.414902238806019 FBN1 1 GO:0036166 phenotypic switching 1/308 17/18722 0.245815739182745 0.414902238806019 SOD2 1 GO:0042448 progesterone metabolic process 1/308 17/18722 0.245815739182745 0.414902238806019 EGR1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/308 17/18722 0.245815739182745 0.414902238806019 SOCS3 1 GO:0042772 DNA damage response, signal transduction resulting in transcription 1/308 17/18722 0.245815739182745 0.414902238806019 RPS27L 1 GO:0042953 lipoprotein transport 1/308 17/18722 0.245815739182745 0.414902238806019 VMP1 1 GO:0043117 positive regulation of vascular permeability 1/308 17/18722 0.245815739182745 0.414902238806019 APOE 1 GO:0051580 regulation of neurotransmitter uptake 1/308 17/18722 0.245815739182745 0.414902238806019 SNCA 1 GO:0060644 mammary gland epithelial cell differentiation 1/308 17/18722 0.245815739182745 0.414902238806019 CEBPB 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/308 17/18722 0.245815739182745 0.414902238806019 ZFP36 1 GO:0070293 renal absorption 1/308 17/18722 0.245815739182745 0.414902238806019 SGK1 1 GO:0070875 positive regulation of glycogen metabolic process 1/308 17/18722 0.245815739182745 0.414902238806019 HMGB1 1 GO:0072673 lamellipodium morphogenesis 1/308 17/18722 0.245815739182745 0.414902238806019 SNX2 1 GO:0090036 regulation of protein kinase C signaling 1/308 17/18722 0.245815739182745 0.414902238806019 MYADM 1 GO:0090136 epithelial cell-cell adhesion 1/308 17/18722 0.245815739182745 0.414902238806019 DSP 1 GO:0090494 dopamine uptake 1/308 17/18722 0.245815739182745 0.414902238806019 SNCA 1 GO:1901550 regulation of endothelial cell development 1/308 17/18722 0.245815739182745 0.414902238806019 IL1B 1 GO:1903140 regulation of establishment of endothelial barrier 1/308 17/18722 0.245815739182745 0.414902238806019 IL1B 1 GO:1903541 regulation of exosomal secretion 1/308 17/18722 0.245815739182745 0.414902238806019 SDCBP 1 GO:1904355 positive regulation of telomere capping 1/308 17/18722 0.245815739182745 0.414902238806019 PKIB 1 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 1/308 17/18722 0.245815739182745 0.414902238806019 STAT1 1 GO:2000811 negative regulation of anoikis 1/308 17/18722 0.245815739182745 0.414902238806019 MCL1 1 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 6/308 256/18722 0.246743255473159 0.416283965434195 FBN2/HSPA1A/HSP90AB1/SDCBP/FBN1/HES1 6 GO:0010043 response to zinc ion 2/308 58/18722 0.247202598244238 0.416324023386662 SOD2/S100A8 2 GO:0045604 regulation of epidermal cell differentiation 2/308 58/18722 0.247202598244238 0.416324023386662 ZFP36/HES1 2 GO:0050432 catecholamine secretion 2/308 58/18722 0.247202598244238 0.416324023386662 SNCA/LY6E 2 GO:1902808 positive regulation of cell cycle G1/S phase transition 2/308 58/18722 0.247202598244238 0.416324023386662 EGFR/ANXA1 2 GO:0016079 synaptic vesicle exocytosis 3/308 105/18722 0.249193975566684 0.418939564024377 SNCA/VAMP2/CALM1 3 GO:0032231 regulation of actin filament bundle assembly 3/308 105/18722 0.249193975566684 0.418939564024377 SWAP70/PTGER4/RAC1 3 GO:0040029 regulation of gene expression, epigenetic 3/308 105/18722 0.249193975566684 0.418939564024377 KLF2/HNRNPU/XIST 3 GO:2001022 positive regulation of response to DNA damage stimulus 3/308 105/18722 0.249193975566684 0.418939564024377 EGFR/HMGB1/DDX5 3 GO:0005996 monosaccharide metabolic process 6/308 257/18722 0.249471458544899 0.419221708139406 PHLDA2/HK2/OAS1/ATF3/HMGB1/ALDOA 6 GO:0016311 dephosphorylation 9/308 417/18722 0.249969289321628 0.419873722792875 PPP1R15A/DUSP1/SWAP70/ENSA/PPP4C/CAMTA1/HSP90AB1/NT5C3A/CALM1 9 GO:0017038 protein import 5/308 206/18722 0.252167714172236 0.423194544021272 NFKBIA/HSP90AB1/APOE/HSP90AA1/TXNIP 5 GO:0048863 stem cell differentiation 5/308 206/18722 0.252167714172236 0.423194544021272 EIF2AK2/CHD2/HNRNPU/FN1/HES1 5 GO:0019369 arachidonic acid metabolic process 2/308 59/18722 0.253309627984654 0.424306145566733 PTGES3/CBR1 2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/308 59/18722 0.253309627984654 0.424306145566733 KLF4/SOCS3 2 GO:0051055 negative regulation of lipid biosynthetic process 2/308 59/18722 0.253309627984654 0.424306145566733 APOE/APOC1 2 GO:2001258 negative regulation of cation channel activity 2/308 59/18722 0.253309627984654 0.424306145566733 SRI/CALM1 2 GO:0030038 contractile actin filament bundle assembly 3/308 106/18722 0.253606995192253 0.424306145566733 PTGER4/PHACTR1/RAC1 3 GO:0043149 stress fiber assembly 3/308 106/18722 0.253606995192253 0.424306145566733 PTGER4/PHACTR1/RAC1 3 GO:0090263 positive regulation of canonical Wnt signaling pathway 3/308 106/18722 0.253606995192253 0.424306145566733 UBE2B/RPS12/EGFR 3 GO:0070588 calcium ion transmembrane transport 7/308 312/18722 0.255266007394083 0.424980474160041 CCL3/SNCA/SRI/C4orf3/CALM1/VMP1/CXCL10 7 GO:0035051 cardiocyte differentiation 4/308 156/18722 0.255506285151829 0.424980474160041 CACYBP/EGFR/HNRNPU/HES1 4 GO:0006260 DNA replication 6/308 260/18722 0.257707073399894 0.424980474160041 JUN/CACYBP/EGFR/RAC1/SET/NAP1L1 6 GO:0005976 polysaccharide metabolic process 3/308 107/18722 0.258031188323557 0.424980474160041 PHLDA2/PTGES3/HMGB1 3 GO:0001956 positive regulation of neurotransmitter secretion 1/308 18/18722 0.258234277131513 0.424980474160041 SNCA 1 GO:0002076 osteoblast development 1/308 18/18722 0.258234277131513 0.424980474160041 JUND 1 GO:0006085 acetyl-CoA biosynthetic process 1/308 18/18722 0.258234277131513 0.424980474160041 MPC2 1 GO:0006337 nucleosome disassembly 1/308 18/18722 0.258234277131513 0.424980474160041 SET 1 GO:0006957 complement activation, alternative pathway 1/308 18/18722 0.258234277131513 0.424980474160041 CFD 1 GO:0009125 nucleoside monophosphate catabolic process 1/308 18/18722 0.258234277131513 0.424980474160041 TYMP 1 GO:0010985 negative regulation of lipoprotein particle clearance 1/308 18/18722 0.258234277131513 0.424980474160041 APOC1 1 GO:0015732 prostaglandin transport 1/308 18/18722 0.258234277131513 0.424980474160041 IL1B 1 GO:0031649 heat generation 1/308 18/18722 0.258234277131513 0.424980474160041 IL1B 1 GO:0032305 positive regulation of icosanoid secretion 1/308 18/18722 0.258234277131513 0.424980474160041 IL1B 1 GO:0032769 negative regulation of monooxygenase activity 1/308 18/18722 0.258234277131513 0.424980474160041 SNCA 1 GO:0035372 protein localization to microtubule 1/308 18/18722 0.258234277131513 0.424980474160041 HNRNPU 1 GO:0036499 PERK-mediated unfolded protein response 1/308 18/18722 0.258234277131513 0.424980474160041 PPP1R15A 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/308 18/18722 0.258234277131513 0.424980474160041 NCL 1 GO:0043217 myelin maintenance 1/308 18/18722 0.258234277131513 0.424980474160041 CXCR4 1 GO:0044247 cellular polysaccharide catabolic process 1/308 18/18722 0.258234277131513 0.424980474160041 HMGB1 1 GO:0044872 lipoprotein localization 1/308 18/18722 0.258234277131513 0.424980474160041 VMP1 1 GO:0045623 negative regulation of T-helper cell differentiation 1/308 18/18722 0.258234277131513 0.424980474160041 ANXA1 1 GO:0046851 negative regulation of bone remodeling 1/308 18/18722 0.258234277131513 0.424980474160041 TNFAIP3 1 GO:0048486 parasympathetic nervous system development 1/308 18/18722 0.258234277131513 0.424980474160041 HES1 1 GO:0050665 hydrogen peroxide biosynthetic process 1/308 18/18722 0.258234277131513 0.424980474160041 SOD2 1 GO:0051447 negative regulation of meiotic cell cycle 1/308 18/18722 0.258234277131513 0.424980474160041 DUSP1 1 GO:0051782 negative regulation of cell division 1/308 18/18722 0.258234277131513 0.424980474160041 TXNIP 1 GO:0090493 catecholamine uptake 1/308 18/18722 0.258234277131513 0.424980474160041 SNCA 1 GO:0110154 RNA decapping 1/308 18/18722 0.258234277131513 0.424980474160041 ZFP36 1 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/308 18/18722 0.258234277131513 0.424980474160041 ZFP36 1 GO:1900225 regulation of NLRP3 inflammasome complex assembly 1/308 18/18722 0.258234277131513 0.424980474160041 EIF2AK2 1 GO:1900242 regulation of synaptic vesicle endocytosis 1/308 18/18722 0.258234277131513 0.424980474160041 CALM1 1 GO:1901317 regulation of flagellated sperm motility 1/308 18/18722 0.258234277131513 0.424980474160041 DEFB1 1 GO:1902074 response to salt 1/308 18/18722 0.258234277131513 0.424980474160041 HNRNPA1 1 GO:1903209 positive regulation of oxidative stress-induced cell death 1/308 18/18722 0.258234277131513 0.424980474160041 MCL1 1 GO:1905820 positive regulation of chromosome separation 1/308 18/18722 0.258234277131513 0.424980474160041 PLSCR1 1 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 1/308 18/18722 0.258234277131513 0.424980474160041 HES1 1 GO:2000641 regulation of early endosome to late endosome transport 1/308 18/18722 0.258234277131513 0.424980474160041 SNX3 1 GO:0009620 response to fungus 2/308 60/18722 0.259420093604204 0.425649363883637 S100A8/S100A9 2 GO:0030071 regulation of mitotic metaphase/anaphase transition 2/308 60/18722 0.259420093604204 0.425649363883637 DUSP1/IK 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/308 60/18722 0.259420093604204 0.425649363883637 SNCA/MPC2 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/308 60/18722 0.259420093604204 0.425649363883637 SNCA/MPC2 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/308 60/18722 0.259420093604204 0.425649363883637 SNCA/MPC2 2 GO:0055008 cardiac muscle tissue morphogenesis 2/308 60/18722 0.259420093604204 0.425649363883637 LY6E/DSP 2 GO:0061951 establishment of protein localization to plasma membrane 2/308 60/18722 0.259420093604204 0.425649363883637 VAMP2/RAB8A 2 GO:0009150 purine ribonucleotide metabolic process 8/308 368/18722 0.261052336754412 0.42814375092755 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/LDHA/ALDOA 8 GO:0006900 vesicle budding from membrane 2/308 61/18722 0.265532235212319 0.434931334711524 CHMP5/SNX3 2 GO:0030865 cortical cytoskeleton organization 2/308 61/18722 0.265532235212319 0.434931334711524 RHOB/RAC1 2 GO:0050994 regulation of lipid catabolic process 2/308 61/18722 0.265532235212319 0.434931334711524 IL1B/APOC1 2 GO:0051170 import into nucleus 4/308 159/18722 0.266347329191363 0.436079588650355 NFKBIA/HSP90AB1/HNRNPA1/TXNIP 4 GO:0034766 negative regulation of ion transmembrane transport 3/308 109/18722 0.266910013680986 0.436255889769998 SRI/C4orf3/CALM1 3 GO:0072009 nephron epithelium development 3/308 109/18722 0.266910013680986 0.436255889769998 BASP1/STAT1/HES1 3 GO:0035637 multicellular organismal signaling 4/308 160/18722 0.269979972127484 0.436255889769998 SRI/TYMP/DSP/CALM1 4 GO:0043271 negative regulation of ion transport 4/308 160/18722 0.269979972127484 0.436255889769998 SNCA/SRI/C4orf3/CALM1 4 GO:0001696 gastric acid secretion 1/308 19/18722 0.270448982148809 0.436255889769998 SGK1 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/308 19/18722 0.270448982148809 0.436255889769998 SOD2 1 GO:0006007 glucose catabolic process 1/308 19/18722 0.270448982148809 0.436255889769998 HK2 1 GO:0006309 apoptotic DNA fragmentation 1/308 19/18722 0.270448982148809 0.436255889769998 DNASE2 1 GO:0006670 sphingosine metabolic process 1/308 19/18722 0.270448982148809 0.436255889769998 ASAH1 1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 1/308 19/18722 0.270448982148809 0.436255889769998 TYMP 1 GO:0009301 snRNA transcription 1/308 19/18722 0.270448982148809 0.436255889769998 LARP7 1 GO:0010829 negative regulation of glucose transmembrane transport 1/308 19/18722 0.270448982148809 0.436255889769998 IL1B 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/308 19/18722 0.270448982148809 0.436255889769998 KLF4 1 GO:0016082 synaptic vesicle priming 1/308 19/18722 0.270448982148809 0.436255889769998 SNCA 1 GO:0032026 response to magnesium ion 1/308 19/18722 0.270448982148809 0.436255889769998 SNCA 1 GO:0034501 protein localization to kinetochore 1/308 19/18722 0.270448982148809 0.436255889769998 IK 1 GO:0043652 engulfment of apoptotic cell 1/308 19/18722 0.270448982148809 0.436255889769998 RAC1 1 GO:0044546 NLRP3 inflammasome complex assembly 1/308 19/18722 0.270448982148809 0.436255889769998 EIF2AK2 1 GO:0044827 modulation by host of viral genome replication 1/308 19/18722 0.270448982148809 0.436255889769998 IFI27 1 GO:0045603 positive regulation of endothelial cell differentiation 1/308 19/18722 0.270448982148809 0.436255889769998 BTG1 1 GO:0045780 positive regulation of bone resorption 1/308 19/18722 0.270448982148809 0.436255889769998 EGFR 1 GO:0046716 muscle cell cellular homeostasis 1/308 19/18722 0.270448982148809 0.436255889769998 ALDOA 1 GO:0046794 transport of virus 1/308 19/18722 0.270448982148809 0.436255889769998 BST2 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/308 19/18722 0.270448982148809 0.436255889769998 CXCR4 1 GO:0061323 cell proliferation involved in heart morphogenesis 1/308 19/18722 0.270448982148809 0.436255889769998 HES1 1 GO:0062099 negative regulation of programmed necrotic cell death 1/308 19/18722 0.270448982148809 0.436255889769998 NUPR1 1 GO:0070233 negative regulation of T cell apoptotic process 1/308 19/18722 0.270448982148809 0.436255889769998 TSC22D3 1 GO:0072077 renal vesicle morphogenesis 1/308 19/18722 0.270448982148809 0.436255889769998 STAT1 1 GO:0098780 response to mitochondrial depolarisation 1/308 19/18722 0.270448982148809 0.436255889769998 HK2 1 GO:1900221 regulation of amyloid-beta clearance 1/308 19/18722 0.270448982148809 0.436255889769998 APOE 1 GO:1901739 regulation of myoblast fusion 1/308 19/18722 0.270448982148809 0.436255889769998 CXCL10 1 GO:1903083 protein localization to condensed chromosome 1/308 19/18722 0.270448982148809 0.436255889769998 IK 1 GO:1903978 regulation of microglial cell activation 1/308 19/18722 0.270448982148809 0.436255889769998 CCL3 1 GO:2000319 regulation of T-helper 17 cell differentiation 1/308 19/18722 0.270448982148809 0.436255889769998 NFKBIZ 1 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 1/308 19/18722 0.270448982148809 0.436255889769998 HLA-A 1 GO:0007088 regulation of mitotic nuclear division 3/308 110/18722 0.271363128688647 0.436893709817896 DUSP1/IL1B/IK 3 GO:0030317 flagellated sperm motility 3/308 110/18722 0.271363128688647 0.436893709817896 UBE2B/DNAJA1/DEFB1 3 GO:0097722 sperm motility 3/308 110/18722 0.271363128688647 0.436893709817896 UBE2B/DNAJA1/DEFB1 3 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 2/308 62/18722 0.271644349525802 0.436893709817896 DUSP1/IK 2 GO:0019933 cAMP-mediated signaling 2/308 62/18722 0.271644349525802 0.436893709817896 UBE2B/DEFB1 2 GO:0060135 maternal process involved in female pregnancy 2/308 62/18722 0.271644349525802 0.436893709817896 JUNB/PRDX3 2 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 2/308 62/18722 0.271644349525802 0.436893709817896 VAMP2/RAB8A 2 GO:0008202 steroid metabolic process 7/308 319/18722 0.272914103648628 0.438751311290456 YWHAH/COMT/EGR1/IGFBP7/APOE/ASAH1/APOC1 7 GO:0009416 response to light stimulus 7/308 320/18722 0.275461783261177 0.442660948889231 JUND/FOS/DUSP1/UBE2B/CIRBP/EGFR/NPM1 7 GO:0015718 monocarboxylic acid transport 3/308 111/18722 0.275824382981465 0.443057401738715 MPC2/IL1B/ANXA1 3 GO:0072330 monocarboxylic acid biosynthetic process 5/308 214/18722 0.277135308657556 0.444976180175487 IL1B/PTGES3/CBR1/ANXA1/APOC1 5 GO:0032233 positive regulation of actin filament bundle assembly 2/308 63/18722 0.277754788492996 0.445222874804496 SWAP70/RAC1 2 GO:0050854 regulation of antigen receptor-mediated signaling pathway 2/308 63/18722 0.277754788492996 0.445222874804496 GBP1/LAPTM5 2 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 2/308 63/18722 0.277754788492996 0.445222874804496 DUSP1/IK 2 GO:2000242 negative regulation of reproductive process 2/308 63/18722 0.277754788492996 0.445222874804496 DUSP1/SERPINF1 2 GO:0010976 positive regulation of neuron projection development 4/308 163/18722 0.28092894029173 0.446775660782469 SERPINF1/SNX3/APOE/S100A9 4 GO:0000272 polysaccharide catabolic process 1/308 20/18722 0.282463189147588 0.446775660782469 HMGB1 1 GO:0001832 blastocyst growth 1/308 20/18722 0.282463189147588 0.446775660782469 SBDS 1 GO:0002115 store-operated calcium entry 1/308 20/18722 0.282463189147588 0.446775660782469 SARAF 1 GO:0006700 C21-steroid hormone biosynthetic process 1/308 20/18722 0.282463189147588 0.446775660782469 EGR1 1 GO:0006837 serotonin transport 1/308 20/18722 0.282463189147588 0.446775660782469 SNCA 1 GO:0006896 Golgi to vacuole transport 1/308 20/18722 0.282463189147588 0.446775660782469 LAPTM5 1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 1/308 20/18722 0.282463189147588 0.446775660782469 TYMP 1 GO:0010042 response to manganese ion 1/308 20/18722 0.282463189147588 0.446775660782469 SOD2 1 GO:0014047 glutamate secretion 1/308 20/18722 0.282463189147588 0.446775660782469 SNCA 1 GO:0016553 base conversion or substitution editing 1/308 20/18722 0.282463189147588 0.446775660782469 APOBEC3A 1 GO:0017121 plasma membrane phospholipid scrambling 1/308 20/18722 0.282463189147588 0.446775660782469 PLSCR1 1 GO:0031498 chromatin disassembly 1/308 20/18722 0.282463189147588 0.446775660782469 SET 1 GO:0032930 positive regulation of superoxide anion generation 1/308 20/18722 0.282463189147588 0.446775660782469 EGFR 1 GO:0032986 protein-DNA complex disassembly 1/308 20/18722 0.282463189147588 0.446775660782469 SET 1 GO:0034104 negative regulation of tissue remodeling 1/308 20/18722 0.282463189147588 0.446775660782469 TNFAIP3 1 GO:0043586 tongue development 1/308 20/18722 0.282463189147588 0.446775660782469 EGFR 1 GO:0043691 reverse cholesterol transport 1/308 20/18722 0.282463189147588 0.446775660782469 APOE 1 GO:0051004 regulation of lipoprotein lipase activity 1/308 20/18722 0.282463189147588 0.446775660782469 APOC1 1 GO:0051900 regulation of mitochondrial depolarization 1/308 20/18722 0.282463189147588 0.446775660782469 IFI6 1 GO:0061318 renal filtration cell differentiation 1/308 20/18722 0.282463189147588 0.446775660782469 BASP1 1 GO:0071379 cellular response to prostaglandin stimulus 1/308 20/18722 0.282463189147588 0.446775660782469 PTGER4 1 GO:0072087 renal vesicle development 1/308 20/18722 0.282463189147588 0.446775660782469 STAT1 1 GO:0072112 glomerular visceral epithelial cell differentiation 1/308 20/18722 0.282463189147588 0.446775660782469 BASP1 1 GO:0097150 neuronal stem cell population maintenance 1/308 20/18722 0.282463189147588 0.446775660782469 HES1 1 GO:0140632 inflammasome complex assembly 1/308 20/18722 0.282463189147588 0.446775660782469 EIF2AK2 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/308 20/18722 0.282463189147588 0.446775660782469 CALM1 1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1/308 20/18722 0.282463189147588 0.446775660782469 SOD2 1 GO:1904292 regulation of ERAD pathway 1/308 20/18722 0.282463189147588 0.446775660782469 HERPUD1 1 GO:1990182 exosomal secretion 1/308 20/18722 0.282463189147588 0.446775660782469 SDCBP 1 GO:2000010 positive regulation of protein localization to cell surface 1/308 20/18722 0.282463189147588 0.446775660782469 HSP90AB1 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/308 20/18722 0.282463189147588 0.446775660782469 PKIB 1 GO:0001885 endothelial cell development 2/308 64/18722 0.283861957947665 0.448061216033825 IL1B/MYADM 2 GO:0030837 negative regulation of actin filament polymerization 2/308 64/18722 0.283861957947665 0.448061216033825 TMSB4X/MYADM 2 GO:0030888 regulation of B cell proliferation 2/308 64/18722 0.283861957947665 0.448061216033825 GPR183/TNFSF13B 2 GO:0045995 regulation of embryonic development 2/308 64/18722 0.283861957947665 0.448061216033825 PHLDA2/HES1 2 GO:1900076 regulation of cellular response to insulin stimulus 2/308 64/18722 0.283861957947665 0.448061216033825 IL1B/SOCS3 2 GO:0044344 cellular response to fibroblast growth factor stimulus 3/308 113/18722 0.284768380585318 0.449306446131931 SNCA/CXCL8/ZFP36 3 GO:0009117 nucleotide metabolic process 10/308 489/18722 0.286303611951059 0.45154237148882 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/TYMP/LDHA/NT5C3A/ALDOA 10 GO:0007596 blood coagulation 5/308 217/18722 0.286628396408496 0.451868189472034 FBLN1/PLSCR1/APOE/FN1/CD9 5 GO:0050878 regulation of body fluid levels 8/308 379/18722 0.286893057161967 0.452098993211129 FBLN1/PLSCR1/HK2/OAS2/EGFR/APOE/FN1/CD9 8 GO:0046661 male sex differentiation 4/308 165/18722 0.288266664220704 0.453702534917971 HMGB2/NUPR1/TNFSF10/UBB 4 GO:0071772 response to BMP 4/308 165/18722 0.288266664220704 0.453702534917971 EGR1/DDX5/FBN1/HES1 4 GO:0071773 cellular response to BMP stimulus 4/308 165/18722 0.288266664220704 0.453702534917971 EGR1/DDX5/FBN1/HES1 4 GO:0019751 polyol metabolic process 3/308 114/18722 0.289249683923017 0.454008524210225 SNCA/ISYNA1/ASAH1 3 GO:0046660 female sex differentiation 3/308 114/18722 0.289249683923017 0.454008524210225 CEBPB/NUPR1/UBB 3 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3/308 114/18722 0.289249683923017 0.454008524210225 HSP90AB1/SDCBP/HES1 3 GO:0010965 regulation of mitotic sister chromatid separation 2/308 65/18722 0.289964316291977 0.454008524210225 DUSP1/IK 2 GO:0035418 protein localization to synapse 2/308 65/18722 0.289964316291977 0.454008524210225 VAMP2/RAB8A 2 GO:0044784 metaphase/anaphase transition of cell cycle 2/308 65/18722 0.289964316291977 0.454008524210225 DUSP1/IK 2 GO:0045682 regulation of epidermis development 2/308 65/18722 0.289964316291977 0.454008524210225 ZFP36/HES1 2 GO:0046916 cellular transition metal ion homeostasis 3/308 115/18722 0.293736246743946 0.454008524210225 SRI/S100A8/S100A9 3 GO:1901989 positive regulation of cell cycle phase transition 3/308 115/18722 0.293736246743946 0.454008524210225 EGFR/NPM1/ANXA1 3 GO:0000002 mitochondrial genome maintenance 1/308 21/18722 0.294280178653659 0.454008524210225 TYMP 1 GO:0002689 negative regulation of leukocyte chemotaxis 1/308 21/18722 0.294280178653659 0.454008524210225 DUSP1 1 GO:0006067 ethanol metabolic process 1/308 21/18722 0.294280178653659 0.454008524210225 ALDH2 1 GO:0006244 pyrimidine nucleotide catabolic process 1/308 21/18722 0.294280178653659 0.454008524210225 TYMP 1 GO:0006925 inflammatory cell apoptotic process 1/308 21/18722 0.294280178653659 0.454008524210225 ANXA1 1 GO:0007289 spermatid nucleus differentiation 1/308 21/18722 0.294280178653659 0.454008524210225 HMGB2 1 GO:0007350 blastoderm segmentation 1/308 21/18722 0.294280178653659 0.454008524210225 BASP1 1 GO:0030449 regulation of complement activation 1/308 21/18722 0.294280178653659 0.454008524210225 IL1B 1 GO:0032288 myelin assembly 1/308 21/18722 0.294280178653659 0.454008524210225 CD9 1 GO:0032303 regulation of icosanoid secretion 1/308 21/18722 0.294280178653659 0.454008524210225 IL1B 1 GO:0034312 diol biosynthetic process 1/308 21/18722 0.294280178653659 0.454008524210225 ASAH1 1 GO:0034471 ncRNA 5'-end processing 1/308 21/18722 0.294280178653659 0.454008524210225 SSB 1 GO:0035813 regulation of renal sodium excretion 1/308 21/18722 0.294280178653659 0.454008524210225 COMT 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/308 21/18722 0.294280178653659 0.454008524210225 EGFR 1 GO:0039702 viral budding via host ESCRT complex 1/308 21/18722 0.294280178653659 0.454008524210225 CHMP1B 1 GO:0042454 ribonucleoside catabolic process 1/308 21/18722 0.294280178653659 0.454008524210225 APOBEC3A 1 GO:0043576 regulation of respiratory gaseous exchange 1/308 21/18722 0.294280178653659 0.454008524210225 NR4A2 1 GO:0044342 type B pancreatic cell proliferation 1/308 21/18722 0.294280178653659 0.454008524210225 NUPR1 1 GO:0045717 negative regulation of fatty acid biosynthetic process 1/308 21/18722 0.294280178653659 0.454008524210225 APOC1 1 GO:0046514 ceramide catabolic process 1/308 21/18722 0.294280178653659 0.454008524210225 ASAH1 1 GO:0046519 sphingoid metabolic process 1/308 21/18722 0.294280178653659 0.454008524210225 ASAH1 1 GO:0046599 regulation of centriole replication 1/308 21/18722 0.294280178653659 0.454008524210225 NPM1 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/308 21/18722 0.294280178653659 0.454008524210225 HLA-A 1 GO:0046885 regulation of hormone biosynthetic process 1/308 21/18722 0.294280178653659 0.454008524210225 EGR1 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/308 21/18722 0.294280178653659 0.454008524210225 CXCR4 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/308 21/18722 0.294280178653659 0.454008524210225 SOD2 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/308 21/18722 0.294280178653659 0.454008524210225 STAT1 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/308 21/18722 0.294280178653659 0.454008524210225 STAT1 1 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 1/308 21/18722 0.294280178653659 0.454008524210225 LAPTM5 1 GO:0070269 pyroptosis 1/308 21/18722 0.294280178653659 0.454008524210225 CASP1 1 GO:0072311 glomerular epithelial cell differentiation 1/308 21/18722 0.294280178653659 0.454008524210225 BASP1 1 GO:0090141 positive regulation of mitochondrial fission 1/308 21/18722 0.294280178653659 0.454008524210225 RALA 1 GO:0097062 dendritic spine maintenance 1/308 21/18722 0.294280178653659 0.454008524210225 APOE 1 GO:0097734 extracellular exosome biogenesis 1/308 21/18722 0.294280178653659 0.454008524210225 SDCBP 1 GO:0150105 protein localization to cell-cell junction 1/308 21/18722 0.294280178653659 0.454008524210225 DSP 1 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/308 21/18722 0.294280178653659 0.454008524210225 HSPA1A 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/308 21/18722 0.294280178653659 0.454008524210225 VAMP2 1 GO:1902307 positive regulation of sodium ion transmembrane transport 1/308 21/18722 0.294280178653659 0.454008524210225 GLRX 1 GO:2000774 positive regulation of cellular senescence 1/308 21/18722 0.294280178653659 0.454008524210225 B2M 1 GO:2001014 regulation of skeletal muscle cell differentiation 1/308 21/18722 0.294280178653659 0.454008524210225 DDX5 1 GO:0030111 regulation of Wnt signaling pathway 7/308 328/18722 0.296055166172907 0.455468332705916 UBE2B/TNFAIP3/EGR1/RPS12/EGFR/SNX3/APOE 7 GO:0006303 double-strand break repair via nonhomologous end joining 2/308 66/18722 0.296060373208005 0.455468332705916 HMGB2/HMGB1 2 GO:0030193 regulation of blood coagulation 2/308 66/18722 0.296060373208005 0.455468332705916 APOE/CD9 2 GO:0032715 negative regulation of interleukin-6 production 2/308 66/18722 0.296060373208005 0.455468332705916 KLF2/TNFAIP3 2 GO:0046626 regulation of insulin receptor signaling pathway 2/308 66/18722 0.296060373208005 0.455468332705916 IL1B/SOCS3 2 GO:0071300 cellular response to retinoic acid 2/308 66/18722 0.296060373208005 0.455468332705916 KLF4/SERPINF1 2 GO:1905953 negative regulation of lipid localization 2/308 66/18722 0.296060373208005 0.455468332705916 NFKBIA/APOC1 2 GO:0008286 insulin receptor signaling pathway 3/308 116/18722 0.298227373818159 0.458617558369599 IL1B/GRB2/SOCS3 3 GO:0042692 muscle cell differentiation 8/308 384/18722 0.298852373612977 0.459393897998557 SOD2/CACYBP/BHLHE41/KRT8/HNRNPU/CD9/HES1/CXCL10 8 GO:0016482 cytosolic transport 4/308 168/18722 0.299322743862805 0.459932013580186 SNX2/SNX3/GCC2/LAPTM5 4 GO:0009259 ribonucleotide metabolic process 8/308 385/18722 0.301258395446283 0.462720307670205 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/LDHA/ALDOA 8 GO:0006513 protein monoubiquitination 2/308 67/18722 0.30214868839718 0.463124726296281 UBE2B/UBB 2 GO:0032890 regulation of organic acid transport 2/308 67/18722 0.30214868839718 0.463124726296281 SNCA/IL1B 2 GO:0042130 negative regulation of T cell proliferation 2/308 67/18722 0.30214868839718 0.463124726296281 HLA-DRB1/CEBPB 2 GO:0051306 mitotic sister chromatid separation 2/308 67/18722 0.30214868839718 0.463124726296281 DUSP1/IK 2 GO:0070527 platelet aggregation 2/308 67/18722 0.30214868839718 0.463124726296281 FN1/CD9 2 GO:0007599 hemostasis 5/308 222/18722 0.30257978434279 0.463124726296281 FBLN1/PLSCR1/APOE/FN1/CD9 5 GO:0050817 coagulation 5/308 222/18722 0.30257978434279 0.463124726296281 FBLN1/PLSCR1/APOE/FN1/CD9 5 GO:0014902 myotube differentiation 3/308 117/18722 0.302722379920642 0.463124726296281 BHLHE41/CD9/CXCL10 3 GO:0030301 cholesterol transport 3/308 117/18722 0.302722379920642 0.463124726296281 NFKBIA/APOE/APOC1 3 GO:0007548 sex differentiation 6/308 276/18722 0.30273311300403 0.463124726296281 CEBPB/HMGB2/NUPR1/BASP1/TNFSF10/UBB 6 GO:0000075 cell cycle checkpoint signaling 4/308 169/18722 0.303019702316539 0.463192451801731 DUSP1/SYF2/IK/RPS27L 4 GO:0009152 purine ribonucleotide biosynthetic process 4/308 169/18722 0.303019702316539 0.463192451801731 SNCA/TMSB4X/MPC2/ALDOA 4 GO:0006753 nucleoside phosphate metabolic process 10/308 497/18722 0.303143705369313 0.463196796813303 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/TYMP/LDHA/NT5C3A/ALDOA 10 GO:0002053 positive regulation of mesenchymal cell proliferation 1/308 22/18722 0.305903177689789 0.46389045946373 STAT1 1 GO:0002320 lymphoid progenitor cell differentiation 1/308 22/18722 0.305903177689789 0.46389045946373 HES1 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/308 22/18722 0.305903177689789 0.46389045946373 CD9 1 GO:0008211 glucocorticoid metabolic process 1/308 22/18722 0.305903177689789 0.46389045946373 YWHAH 1 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1/308 22/18722 0.305903177689789 0.46389045946373 CALM1 1 GO:0021854 hypothalamus development 1/308 22/18722 0.305903177689789 0.46389045946373 UBB 1 GO:0032816 positive regulation of natural killer cell activation 1/308 22/18722 0.305903177689789 0.46389045946373 HLA-F 1 GO:0034629 cellular protein-containing complex localization 1/308 22/18722 0.305903177689789 0.46389045946373 TNFAIP2 1 GO:0035584 calcium-mediated signaling using intracellular calcium source 1/308 22/18722 0.305903177689789 0.46389045946373 DEFB1 1 GO:0043486 histone exchange 1/308 22/18722 0.305903177689789 0.46389045946373 ANP32E 1 GO:0045540 regulation of cholesterol biosynthetic process 1/308 22/18722 0.305903177689789 0.46389045946373 APOE 1 GO:0045663 positive regulation of myoblast differentiation 1/308 22/18722 0.305903177689789 0.46389045946373 BTG1 1 GO:0060343 trabecula formation 1/308 22/18722 0.305903177689789 0.46389045946373 FBN2 1 GO:0060965 negative regulation of gene silencing by miRNA 1/308 22/18722 0.305903177689789 0.46389045946373 NEAT1 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/308 22/18722 0.305903177689789 0.46389045946373 CD9 1 GO:0090280 positive regulation of calcium ion import 1/308 22/18722 0.305903177689789 0.46389045946373 CCL3 1 GO:0106118 regulation of sterol biosynthetic process 1/308 22/18722 0.305903177689789 0.46389045946373 APOE 1 GO:0140467 integrated stress response signaling 1/308 22/18722 0.305903177689789 0.46389045946373 PPP1R15A 1 GO:2000193 positive regulation of fatty acid transport 1/308 22/18722 0.305903177689789 0.46389045946373 IL1B 1 GO:0007259 receptor signaling pathway via JAK-STAT 4/308 170/18722 0.306721802040271 0.464947442188722 NMI/STAT1/SOCS3/HES1 4 GO:1903313 positive regulation of mRNA metabolic process 3/308 118/18722 0.30722058987637 0.465518951683457 NCL/ZFP36/CIRBP 3 GO:0007585 respiratory gaseous exchange by respiratory system 2/308 68/18722 0.308227870347112 0.466490557536424 MAFB/NR4A2 2 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 2/308 68/18722 0.308227870347112 0.466490557536424 TMSB4X/ALDOA 2 GO:1900046 regulation of hemostasis 2/308 68/18722 0.308227870347112 0.466490557536424 APOE/CD9 2 GO:0010975 regulation of neuron projection development 9/308 445/18722 0.311665253457464 0.471506238214439 B2M/YWHAH/KLF4/SERPINF1/SNX3/APOE/FN1/S100A9/LGALS1 9 GO:0051656 establishment of organelle localization 8/308 390/18722 0.313353263373362 0.473872439033371 SNCA/CHMP1B/CHMP5/UBE2B/NPM1/HNRNPU/RPS15/UBB 8 GO:0006368 transcription elongation from RNA polymerase II promoter 2/308 69/18722 0.314296575125231 0.474735601226297 LARP7/HNRNPU 2 GO:0009145 purine nucleoside triphosphate biosynthetic process 2/308 69/18722 0.314296575125231 0.474735601226297 TMSB4X/ALDOA 2 GO:0045665 negative regulation of neuron differentiation 2/308 69/18722 0.314296575125231 0.474735601226297 B2M/HES1 2 GO:0098813 nuclear chromosome segregation 6/308 281/18722 0.3171062793362 0.475381302408972 DUSP1/CHMP1B/CHMP5/UBE2B/IK/HNRNPU 6 GO:0000966 RNA 5'-end processing 1/308 23/18722 0.317335360645487 0.475381302408972 SSB 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/308 23/18722 0.317335360645487 0.475381302408972 TYMP 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/308 23/18722 0.317335360645487 0.475381302408972 SNCA 1 GO:0010888 negative regulation of lipid storage 1/308 23/18722 0.317335360645487 0.475381302408972 NFKBIA 1 GO:0021884 forebrain neuron development 1/308 23/18722 0.317335360645487 0.475381302408972 UBB 1 GO:0030325 adrenal gland development 1/308 23/18722 0.317335360645487 0.475381302408972 LY6E 1 GO:0034695 response to prostaglandin E 1/308 23/18722 0.317335360645487 0.475381302408972 PTGER4 1 GO:0035640 exploration behavior 1/308 23/18722 0.317335360645487 0.475381302408972 APOE 1 GO:0035812 renal sodium excretion 1/308 23/18722 0.317335360645487 0.475381302408972 COMT 1 GO:0045662 negative regulation of myoblast differentiation 1/308 23/18722 0.317335360645487 0.475381302408972 CXCL10 1 GO:0045932 negative regulation of muscle contraction 1/308 23/18722 0.317335360645487 0.475381302408972 SRI 1 GO:0045943 positive regulation of transcription by RNA polymerase I 1/308 23/18722 0.317335360645487 0.475381302408972 NCL 1 GO:0051446 positive regulation of meiotic cell cycle 1/308 23/18722 0.317335360645487 0.475381302408972 UBE2B 1 GO:0051457 maintenance of protein location in nucleus 1/308 23/18722 0.317335360645487 0.475381302408972 HNRNPU 1 GO:0051590 positive regulation of neurotransmitter transport 1/308 23/18722 0.317335360645487 0.475381302408972 SNCA 1 GO:0060487 lung epithelial cell differentiation 1/308 23/18722 0.317335360645487 0.475381302408972 KLF2 1 GO:0060547 negative regulation of necrotic cell death 1/308 23/18722 0.317335360645487 0.475381302408972 NUPR1 1 GO:0140112 extracellular vesicle biogenesis 1/308 23/18722 0.317335360645487 0.475381302408972 SDCBP 1 GO:1903306 negative regulation of regulated secretory pathway 1/308 23/18722 0.317335360645487 0.475381302408972 HLA-F 1 GO:2001169 regulation of ATP biosynthetic process 1/308 23/18722 0.317335360645487 0.475381302408972 TMSB4X 1 GO:0000910 cytokinesis 4/308 173/18722 0.317855062114656 0.475786962593707 CHMP1B/CHMP5/RHOB/CALM1 4 GO:0006694 steroid biosynthetic process 4/308 173/18722 0.317855062114656 0.475786962593707 EGR1/IGFBP7/APOE/ASAH1 4 GO:0010876 lipid localization 9/308 448/18722 0.318483405549443 0.476540923450301 NFKBIA/PLSCR1/PLIN2/IL1B/APOL6/APOE/MEST/ANXA1/APOC1 9 GO:0007265 Ras protein signal transduction 7/308 337/18722 0.319608956509637 0.478037965859289 JUN/RHOB/RALA/GRB2/SDCBP/RAC1/APOE 7 GO:0060415 muscle tissue morphogenesis 2/308 70/18722 0.320353505198713 0.478964196470349 LY6E/DSP 2 GO:0003206 cardiac chamber morphogenesis 3/308 121/18722 0.320727842610413 0.47914909820227 LY6E/DSP/HES1 3 GO:0045931 positive regulation of mitotic cell cycle 3/308 121/18722 0.320727842610413 0.47914909820227 EGFR/HES1/ANXA1 3 GO:0001659 temperature homeostasis 4/308 174/18722 0.321573856122184 0.480225332794965 CEBPB/IL1B/EGR1/CXCR4 4 GO:0051146 striated muscle cell differentiation 6/308 283/18722 0.322885952039949 0.481996483658229 CACYBP/BHLHE41/KRT8/HNRNPU/CD9/CXCL10 6 GO:0071695 anatomical structure maturation 5/308 229/18722 0.325129180510194 0.483324650656895 KLF2/NR4A2/DEFB1/HES1/C1QA 5 GO:0003208 cardiac ventricle morphogenesis 2/308 71/18722 0.326397408280148 0.483324650656895 LY6E/DSP 2 GO:0008344 adult locomotory behavior 2/308 71/18722 0.326397408280148 0.483324650656895 SNCA/NR4A2 2 GO:0050795 regulation of behavior 2/308 71/18722 0.326397408280148 0.483324650656895 CCL3/APOE 2 GO:0050818 regulation of coagulation 2/308 71/18722 0.326397408280148 0.483324650656895 APOE/CD9 2 GO:0061515 myeloid cell development 2/308 71/18722 0.326397408280148 0.483324650656895 KLF2/FBN1 2 GO:0006163 purine nucleotide metabolic process 8/308 396/18722 0.327995088211841 0.483324650656895 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/LDHA/ALDOA 8 GO:0045055 regulated exocytosis 5/308 230/18722 0.328366797552377 0.483324650656895 CCL3/SNCA/VAMP2/HLA-F/CALM1 5 GO:0045333 cellular respiration 5/308 230/18722 0.328366797552377 0.483324650656895 SNCA/NUPR1/SDHD/BID/UQCR11 5 GO:0002021 response to dietary excess 1/308 24/18722 0.328579850132689 0.483324650656895 APOE 1 GO:0002922 positive regulation of humoral immune response 1/308 24/18722 0.328579850132689 0.483324650656895 IL1B 1 GO:0006817 phosphate ion transport 1/308 24/18722 0.328579850132689 0.483324650656895 CEBPB 1 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 1/308 24/18722 0.328579850132689 0.483324650656895 TYMP 1 GO:0010155 regulation of proton transport 1/308 24/18722 0.328579850132689 0.483324650656895 TMSB4X 1 GO:0010288 response to lead ion 1/308 24/18722 0.328579850132689 0.483324650656895 PLSCR1 1 GO:0016048 detection of temperature stimulus 1/308 24/18722 0.328579850132689 0.483324650656895 CXCR4 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/308 24/18722 0.328579850132689 0.483324650656895 TMSB4X 1 GO:0032928 regulation of superoxide anion generation 1/308 24/18722 0.328579850132689 0.483324650656895 EGFR 1 GO:0033032 regulation of myeloid cell apoptotic process 1/308 24/18722 0.328579850132689 0.483324650656895 ANXA1 1 GO:0043302 positive regulation of leukocyte degranulation 1/308 24/18722 0.328579850132689 0.483324650656895 HLA-F 1 GO:0044062 regulation of excretion 1/308 24/18722 0.328579850132689 0.483324650656895 COMT 1 GO:0048011 neurotrophin TRK receptor signaling pathway 1/308 24/18722 0.328579850132689 0.483324650656895 DDIT4 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/308 24/18722 0.328579850132689 0.483324650656895 HMGB1 1 GO:0060149 negative regulation of posttranscriptional gene silencing 1/308 24/18722 0.328579850132689 0.483324650656895 NEAT1 1 GO:0060479 lung cell differentiation 1/308 24/18722 0.328579850132689 0.483324650656895 KLF2 1 GO:0060967 negative regulation of gene silencing by RNA 1/308 24/18722 0.328579850132689 0.483324650656895 NEAT1 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/308 24/18722 0.328579850132689 0.483324650656895 ZFP36 1 GO:0071676 negative regulation of mononuclear cell migration 1/308 24/18722 0.328579850132689 0.483324650656895 DUSP1 1 GO:0072010 glomerular epithelium development 1/308 24/18722 0.328579850132689 0.483324650656895 BASP1 1 GO:0090343 positive regulation of cell aging 1/308 24/18722 0.328579850132689 0.483324650656895 B2M 1 GO:0120255 olefinic compound biosynthetic process 1/308 24/18722 0.328579850132689 0.483324650656895 EGR1 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/308 24/18722 0.328579850132689 0.483324650656895 TMSB4X 1 GO:1903077 negative regulation of protein localization to plasma membrane 1/308 24/18722 0.328579850132689 0.483324650656895 GBP1 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/308 24/18722 0.328579850132689 0.483324650656895 SOD2 1 GO:1903861 positive regulation of dendrite extension 1/308 24/18722 0.328579850132689 0.483324650656895 CXCR4 1 GO:2000209 regulation of anoikis 1/308 24/18722 0.328579850132689 0.483324650656895 MCL1 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/308 24/18722 0.328579850132689 0.483324650656895 KLF4 1 GO:2001026 regulation of endothelial cell chemotaxis 1/308 24/18722 0.328579850132689 0.483324650656895 TMSB4X 1 GO:0003231 cardiac ventricle development 3/308 123/18722 0.329736774032492 0.484653474481437 LY6E/DSP/HES1 3 GO:0010811 positive regulation of cell-substrate adhesion 3/308 123/18722 0.329736774032492 0.484653474481437 RAC1/MYADM/FN1 3 GO:0033627 cell adhesion mediated by integrin 2/308 72/18722 0.332427076198415 0.488044820394217 SWAP70/FBN1 2 GO:0042246 tissue regeneration 2/308 72/18722 0.332427076198415 0.488044820394217 CD9/ANXA1 2 GO:0042273 ribosomal large subunit biogenesis 2/308 72/18722 0.332427076198415 0.488044820394217 NPM1/RPL3 2 GO:0006869 lipid transport 8/308 398/18722 0.332902923956276 0.488555807403011 NFKBIA/PLSCR1/PLIN2/IL1B/APOL6/APOE/ANXA1/APOC1 8 GO:0048015 phosphatidylinositol-mediated signaling 4/308 178/18722 0.336477529558404 0.491834333808655 KLF4/NCF1/EGFR/FN1 4 GO:0032456 endocytic recycling 2/308 73/18722 0.338441343794287 0.491834333808655 RAB8A/SNX3 2 GO:0045739 positive regulation of DNA repair 2/308 73/18722 0.338441343794287 0.491834333808655 EGFR/HMGB1 2 GO:0051145 smooth muscle cell differentiation 2/308 73/18722 0.338441343794287 0.491834333808655 SOD2/HES1 2 GO:0051937 catecholamine transport 2/308 73/18722 0.338441343794287 0.491834333808655 SNCA/LY6E 2 GO:0070988 demethylation 2/308 73/18722 0.338441343794287 0.491834333808655 UBE2B/APOBEC3A 2 GO:0072088 nephron epithelium morphogenesis 2/308 73/18722 0.338441343794287 0.491834333808655 STAT1/HES1 2 GO:0086003 cardiac muscle cell contraction 2/308 73/18722 0.338441343794287 0.491834333808655 SRI/DSP 2 GO:0060294 cilium movement involved in cell motility 3/308 125/18722 0.338743177663434 0.491834333808655 UBE2B/DNAJA1/DEFB1 3 GO:0006658 phosphatidylserine metabolic process 1/308 25/18722 0.339639717827583 0.491834333808655 PLSCR1 1 GO:0007288 sperm axoneme assembly 1/308 25/18722 0.339639717827583 0.491834333808655 UBE2B 1 GO:0010447 response to acidic pH 1/308 25/18722 0.339639717827583 0.491834333808655 SERPINF1 1 GO:0010996 response to auditory stimulus 1/308 25/18722 0.339639717827583 0.491834333808655 CXCL10 1 GO:0015874 norepinephrine transport 1/308 25/18722 0.339639717827583 0.491834333808655 SNCA 1 GO:0016540 protein autoprocessing 1/308 25/18722 0.339639717827583 0.491834333808655 CASP1 1 GO:0031579 membrane raft organization 1/308 25/18722 0.339639717827583 0.491834333808655 MYADM 1 GO:0032469 endoplasmic reticulum calcium ion homeostasis 1/308 25/18722 0.339639717827583 0.491834333808655 HERPUD1 1 GO:0032753 positive regulation of interleukin-4 production 1/308 25/18722 0.339639717827583 0.491834333808655 CEBPB 1 GO:0033233 regulation of protein sumoylation 1/308 25/18722 0.339639717827583 0.491834333808655 EGR1 1 GO:0045822 negative regulation of heart contraction 1/308 25/18722 0.339639717827583 0.491834333808655 SRI 1 GO:0046835 carbohydrate phosphorylation 1/308 25/18722 0.339639717827583 0.491834333808655 HK2 1 GO:0050927 positive regulation of positive chemotaxis 1/308 25/18722 0.339639717827583 0.491834333808655 CXCL8 1 GO:0050951 sensory perception of temperature stimulus 1/308 25/18722 0.339639717827583 0.491834333808655 CXCR4 1 GO:0051204 protein insertion into mitochondrial membrane 1/308 25/18722 0.339639717827583 0.491834333808655 HSP90AA1 1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 1/308 25/18722 0.339639717827583 0.491834333808655 SUB1 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/308 25/18722 0.339639717827583 0.491834333808655 CXCR4 1 GO:0071459 protein localization to chromosome, centromeric region 1/308 25/18722 0.339639717827583 0.491834333808655 IK 1 GO:0072202 cell differentiation involved in metanephros development 1/308 25/18722 0.339639717827583 0.491834333808655 STAT1 1 GO:0090330 regulation of platelet aggregation 1/308 25/18722 0.339639717827583 0.491834333808655 CD9 1 GO:0120316 sperm flagellum assembly 1/308 25/18722 0.339639717827583 0.491834333808655 UBE2B 1 GO:0140448 signaling receptor ligand precursor processing 1/308 25/18722 0.339639717827583 0.491834333808655 CASP1 1 GO:1902932 positive regulation of alcohol biosynthetic process 1/308 25/18722 0.339639717827583 0.491834333808655 SNCA 1 GO:1905048 regulation of metallopeptidase activity 1/308 25/18722 0.339639717827583 0.491834333808655 TIMP3 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/308 25/18722 0.339639717827583 0.491834333808655 HMGB1 1 GO:2000316 regulation of T-helper 17 type immune response 1/308 25/18722 0.339639717827583 0.491834333808655 NFKBIZ 1 GO:0001936 regulation of endothelial cell proliferation 4/308 179/18722 0.340208728263552 0.492285377801498 HMGB2/STAT1/APOE/HMGB1 4 GO:0007626 locomotory behavior 4/308 179/18722 0.340208728263552 0.492285377801498 SNCA/EGR1/NR4A2/APOE 4 GO:0048588 developmental cell growth 5/308 234/18722 0.341347933817962 0.493560193262507 CXCR4/HSP90AB1/APOE/FN1/HSP90AA1 5 GO:0060560 developmental growth involved in morphogenesis 5/308 234/18722 0.341347933817962 0.493560193262507 CXCR4/HSP90AB1/APOE/FN1/HSP90AA1 5 GO:0007040 lysosome organization 2/308 74/18722 0.344439087840221 0.497089706611237 CHMP5/LAPTM5 2 GO:0009201 ribonucleoside triphosphate biosynthetic process 2/308 74/18722 0.344439087840221 0.497089706611237 TMSB4X/ALDOA 2 GO:0048844 artery morphogenesis 2/308 74/18722 0.344439087840221 0.497089706611237 APOE/HES1 2 GO:0080171 lytic vacuole organization 2/308 74/18722 0.344439087840221 0.497089706611237 CHMP5/LAPTM5 2 GO:1903201 regulation of oxidative stress-induced cell death 2/308 74/18722 0.344439087840221 0.497089706611237 SOD2/MCL1 2 GO:0016236 macroautophagy 6/308 291/18722 0.346142070907751 0.499358919652955 BNIP3L/GABARAPL2/NUPR1/MAP1LC3B/CALM1/VMP1 6 GO:0097696 receptor signaling pathway via STAT 4/308 181/18722 0.347674929696351 0.499638425726049 NMI/STAT1/SOCS3/HES1 4 GO:0035270 endocrine system development 3/308 127/18722 0.347742261131581 0.499638425726049 LY6E/HES1/ANXA1 3 GO:0048565 digestive tract development 3/308 127/18722 0.347742261131581 0.499638425726049 CXCL8/EGFR/HES1 3 GO:0043627 response to estrogen 2/308 75/18722 0.350419225983868 0.499638425726049 COMT/LDHA 2 GO:0045913 positive regulation of carbohydrate metabolic process 2/308 75/18722 0.350419225983868 0.499638425726049 SNCA/HMGB1 2 GO:2001259 positive regulation of cation channel activity 2/308 75/18722 0.350419225983868 0.499638425726049 TMSB4X/CALM1 2 GO:0001963 synaptic transmission, dopaminergic 1/308 26/18722 0.350517985298787 0.499638425726049 SNCA 1 GO:0002710 negative regulation of T cell mediated immunity 1/308 26/18722 0.350517985298787 0.499638425726049 HLA-F 1 GO:0009164 nucleoside catabolic process 1/308 26/18722 0.350517985298787 0.499638425726049 APOBEC3A 1 GO:0021952 central nervous system projection neuron axonogenesis 1/308 26/18722 0.350517985298787 0.499638425726049 NR4A2 1 GO:0032515 negative regulation of phosphoprotein phosphatase activity 1/308 26/18722 0.350517985298787 0.499638425726049 PPP1R15A 1 GO:0033522 histone H2A ubiquitination 1/308 26/18722 0.350517985298787 0.499638425726049 UBE2B 1 GO:0033598 mammary gland epithelial cell proliferation 1/308 26/18722 0.350517985298787 0.499638425726049 CEBPB 1 GO:0034063 stress granule assembly 1/308 26/18722 0.350517985298787 0.499638425726049 CIRBP 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/308 26/18722 0.350517985298787 0.499638425726049 UBB 1 GO:0045026 plasma membrane fusion 1/308 26/18722 0.350517985298787 0.499638425726049 CD9 1 GO:0045672 positive regulation of osteoclast differentiation 1/308 26/18722 0.350517985298787 0.499638425726049 FOS 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/308 26/18722 0.350517985298787 0.499638425726049 HLA-F 1 GO:0046697 decidualization 1/308 26/18722 0.350517985298787 0.499638425726049 JUNB 1 GO:0047497 mitochondrion transport along microtubule 1/308 26/18722 0.350517985298787 0.499638425726049 UBB 1 GO:0050926 regulation of positive chemotaxis 1/308 26/18722 0.350517985298787 0.499638425726049 CXCL8 1 GO:0060037 pharyngeal system development 1/308 26/18722 0.350517985298787 0.499638425726049 HES1 1 GO:0060295 regulation of cilium movement involved in cell motility 1/308 26/18722 0.350517985298787 0.499638425726049 DEFB1 1 GO:0070193 synaptonemal complex organization 1/308 26/18722 0.350517985298787 0.499638425726049 UBE2B 1 GO:0071425 hematopoietic stem cell proliferation 1/308 26/18722 0.350517985298787 0.499638425726049 EIF2AK2 1 GO:1902019 regulation of cilium-dependent cell motility 1/308 26/18722 0.350517985298787 0.499638425726049 DEFB1 1 GO:1903523 negative regulation of blood circulation 1/308 26/18722 0.350517985298787 0.499638425726049 SRI 1 GO:1904353 regulation of telomere capping 1/308 26/18722 0.350517985298787 0.499638425726049 PKIB 1 GO:1904376 negative regulation of protein localization to cell periphery 1/308 26/18722 0.350517985298787 0.499638425726049 GBP1 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/308 26/18722 0.350517985298787 0.499638425726049 SOD2 1 GO:1905523 positive regulation of macrophage migration 1/308 26/18722 0.350517985298787 0.499638425726049 CCL3 1 GO:2000108 positive regulation of leukocyte apoptotic process 1/308 26/18722 0.350517985298787 0.499638425726049 ANXA1 1 GO:1901617 organic hydroxy compound biosynthetic process 5/308 237/18722 0.351109124410132 0.50029451458067 SNCA/ISYNA1/NR4A2/APOE/ASAH1 5 GO:0009260 ribonucleotide biosynthetic process 4/308 182/18722 0.35140922326211 0.500349147311376 SNCA/TMSB4X/MPC2/ALDOA 4 GO:0048017 inositol lipid-mediated signaling 4/308 182/18722 0.35140922326211 0.500349147311376 KLF4/NCF1/EGFR/FN1 4 GO:0010948 negative regulation of cell cycle process 6/308 294/18722 0.354907023896021 0.505141307652452 KLF4/DUSP1/SYF2/IK/NPM1/RPS27L 6 GO:0001937 negative regulation of endothelial cell proliferation 2/308 76/18722 0.356380715714805 0.506296349378558 STAT1/APOE 2 GO:0045685 regulation of glial cell differentiation 2/308 76/18722 0.356380715714805 0.506296349378558 CXCR4/HES1 2 GO:0072028 nephron morphogenesis 2/308 76/18722 0.356380715714805 0.506296349378558 STAT1/HES1 2 GO:0086001 cardiac muscle cell action potential 2/308 76/18722 0.356380715714805 0.506296349378558 DSP/CALM1 2 GO:0140029 exocytic process 2/308 76/18722 0.356380715714805 0.506296349378558 SNCA/RAB8A 2 GO:0006638 neutral lipid metabolic process 3/308 129/18722 0.35672939465279 0.506603445675192 SNCA/APOE/APOC1 3 GO:2001257 regulation of cation channel activity 4/308 184/18722 0.358878450747362 0.507510099116102 TMSB4X/VAMP2/SRI/CALM1 4 GO:0006282 regulation of DNA repair 3/308 130/18722 0.361217077701228 0.507510099116102 PPP4C/EGFR/HMGB1 3 GO:0006352 DNA-templated transcription, initiation 3/308 130/18722 0.361217077701228 0.507510099116102 JUN/SUB1/HMGB1 3 GO:0007098 centrosome cycle 3/308 130/18722 0.361217077701228 0.507510099116102 CHMP1B/CHMP5/NPM1 3 GO:0015918 sterol transport 3/308 130/18722 0.361217077701228 0.507510099116102 NFKBIA/APOE/APOC1 3 GO:0000027 ribosomal large subunit assembly 1/308 27/18722 0.361217624822106 0.507510099116102 RPL3 1 GO:0000737 DNA catabolic process, endonucleolytic 1/308 27/18722 0.361217624822106 0.507510099116102 DNASE2 1 GO:0009651 response to salt stress 1/308 27/18722 0.361217624822106 0.507510099116102 HSP90AB1 1 GO:0010528 regulation of transposition 1/308 27/18722 0.361217624822106 0.507510099116102 APOBEC3A 1 GO:0010529 negative regulation of transposition 1/308 27/18722 0.361217624822106 0.507510099116102 APOBEC3A 1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 1/308 27/18722 0.361217624822106 0.507510099116102 CALM1 1 GO:0010894 negative regulation of steroid biosynthetic process 1/308 27/18722 0.361217624822106 0.507510099116102 APOE 1 GO:0014850 response to muscle activity 1/308 27/18722 0.361217624822106 0.507510099116102 METRNL 1 GO:0018126 protein hydroxylation 1/308 27/18722 0.361217624822106 0.507510099116102 P4HA1 1 GO:0018195 peptidyl-arginine modification 1/308 27/18722 0.361217624822106 0.507510099116102 PRMT9 1 GO:0031954 positive regulation of protein autophosphorylation 1/308 27/18722 0.361217624822106 0.507510099116102 CALM1 1 GO:0032781 positive regulation of ATPase activity 1/308 27/18722 0.361217624822106 0.507510099116102 GABARAPL2 1 GO:0033688 regulation of osteoblast proliferation 1/308 27/18722 0.361217624822106 0.507510099116102 EIF2AK2 1 GO:0034453 microtubule anchoring 1/308 27/18722 0.361217624822106 0.507510099116102 GCC2 1 GO:0036037 CD8-positive, alpha-beta T cell activation 1/308 27/18722 0.361217624822106 0.507510099116102 HLA-A 1 GO:0039529 RIG-I signaling pathway 1/308 27/18722 0.361217624822106 0.507510099116102 OAS3 1 GO:0042104 positive regulation of activated T cell proliferation 1/308 27/18722 0.361217624822106 0.507510099116102 HMGB1 1 GO:0042402 cellular biogenic amine catabolic process 1/308 27/18722 0.361217624822106 0.507510099116102 COMT 1 GO:0051953 negative regulation of amine transport 1/308 27/18722 0.361217624822106 0.507510099116102 SNCA 1 GO:0060142 regulation of syncytium formation by plasma membrane fusion 1/308 27/18722 0.361217624822106 0.507510099116102 CXCL10 1 GO:0070861 regulation of protein exit from endoplasmic reticulum 1/308 27/18722 0.361217624822106 0.507510099116102 GCC2 1 GO:1902914 regulation of protein polyubiquitination 1/308 27/18722 0.361217624822106 0.507510099116102 NMI 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/308 27/18722 0.361217624822106 0.507510099116102 MCL1 1 GO:1903859 regulation of dendrite extension 1/308 27/18722 0.361217624822106 0.507510099116102 CXCR4 1 GO:0031346 positive regulation of cell projection organization 7/308 353/18722 0.362186757065161 0.507756276199578 RALA/SERPINF1/SNX3/RAC1/APOE/FN1/S100A9 7 GO:0061564 axon development 9/308 467/18722 0.362289932362012 0.507756276199578 KLF4/HSP90AB1/RAB8A/NR4A2/RAC1/APOE/FN1/HSP90AA1/S100A6 9 GO:0006367 transcription initiation from RNA polymerase II promoter 2/308 77/18722 0.362322553354028 0.507756276199578 SUB1/HMGB1 2 GO:0010827 regulation of glucose transmembrane transport 2/308 77/18722 0.362322553354028 0.507756276199578 IL1B/HK2 2 GO:0021675 nerve development 2/308 77/18722 0.362322553354028 0.507756276199578 MAFB/HES1 2 GO:0031016 pancreas development 2/308 77/18722 0.362322553354028 0.507756276199578 HES1/ANXA1 2 GO:0048644 muscle organ morphogenesis 2/308 77/18722 0.362322553354028 0.507756276199578 LY6E/DSP 2 GO:0002040 sprouting angiogenesis 4/308 185/18722 0.362612697703689 0.507976673990914 KLF2/KLF4/HMGB1/ANXA1 4 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3/308 131/18722 0.365700110468969 0.512114110740977 FBN2/HSPA1A/FBN1 3 GO:0031345 negative regulation of cell projection organization 4/308 186/18722 0.36634624844587 0.512831090372963 B2M/YWHAH/APOE/LGALS1 4 GO:0034637 cellular carbohydrate biosynthetic process 2/308 78/18722 0.368243773065717 0.514921706082749 PTGES3/ISYNA1 2 GO:0061045 negative regulation of wound healing 2/308 78/18722 0.368243773065717 0.514921706082749 APOE/CD9 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2/308 78/18722 0.368243773065717 0.514921706082749 KLF4/ANXA1 2 GO:0000423 mitophagy 1/308 28/18722 0.371741560182085 0.516037757652908 MAP1LC3B 1 GO:0002675 positive regulation of acute inflammatory response 1/308 28/18722 0.371741560182085 0.516037757652908 IL1B 1 GO:0007141 male meiosis I 1/308 28/18722 0.371741560182085 0.516037757652908 UBB 1 GO:0007271 synaptic transmission, cholinergic 1/308 28/18722 0.371741560182085 0.516037757652908 APOE 1 GO:0010464 regulation of mesenchymal cell proliferation 1/308 28/18722 0.371741560182085 0.516037757652908 STAT1 1 GO:0010575 positive regulation of vascular endothelial growth factor production 1/308 28/18722 0.371741560182085 0.516037757652908 IL1B 1 GO:0010884 positive regulation of lipid storage 1/308 28/18722 0.371741560182085 0.516037757652908 PLIN2 1 GO:0030262 apoptotic nuclear changes 1/308 28/18722 0.371741560182085 0.516037757652908 DNASE2 1 GO:0032958 inositol phosphate biosynthetic process 1/308 28/18722 0.371741560182085 0.516037757652908 SNCA 1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1/308 28/18722 0.371741560182085 0.516037757652908 EGFR 1 GO:0045686 negative regulation of glial cell differentiation 1/308 28/18722 0.371741560182085 0.516037757652908 HES1 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/308 28/18722 0.371741560182085 0.516037757652908 SOCS3 1 GO:0050996 positive regulation of lipid catabolic process 1/308 28/18722 0.371741560182085 0.516037757652908 IL1B 1 GO:0051894 positive regulation of focal adhesion assembly 1/308 28/18722 0.371741560182085 0.516037757652908 RAC1 1 GO:0060765 regulation of androgen receptor signaling pathway 1/308 28/18722 0.371741560182085 0.516037757652908 DDX5 1 GO:0061082 myeloid leukocyte cytokine production 1/308 28/18722 0.371741560182085 0.516037757652908 LAPTM5 1 GO:0070076 histone lysine demethylation 1/308 28/18722 0.371741560182085 0.516037757652908 UBE2B 1 GO:0080111 DNA demethylation 1/308 28/18722 0.371741560182085 0.516037757652908 APOBEC3A 1 GO:1903649 regulation of cytoplasmic transport 1/308 28/18722 0.371741560182085 0.516037757652908 SNX3 1 GO:1903671 negative regulation of sprouting angiogenesis 1/308 28/18722 0.371741560182085 0.516037757652908 KLF2 1 GO:0030308 negative regulation of cell growth 4/308 188/18722 0.373809929097946 0.518430733468914 HSPA1A/BST2/HSPA1B/BTG1 4 GO:0000245 spliceosomal complex assembly 2/308 79/18722 0.374143445890853 0.518430733468914 SRSF5/SRSF9 2 GO:0001895 retina homeostasis 2/308 79/18722 0.374143445890853 0.518430733468914 B2M/PRDX1 2 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 2/308 79/18722 0.374143445890853 0.518430733468914 RAC1/MYADM 2 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 2/308 79/18722 0.374143445890853 0.518430733468914 NCF1/FN1 2 GO:0006997 nucleus organization 3/308 133/18722 0.374650101993122 0.518944688376705 CHMP1B/CHMP5/HMGB2 3 GO:0072521 purine-containing compound metabolic process 8/308 416/18722 0.377516713761967 0.522626213846777 SNCA/TMSB4X/MPC2/NUPR1/HK2/DDIT4/LDHA/ALDOA 8 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3/308 134/18722 0.379116024136054 0.522626213846777 SNCA/CXCL8/RGS1 3 GO:0042552 myelination 3/308 134/18722 0.379116024136054 0.522626213846777 CXCR4/TYMP/CD9 3 GO:0071229 cellular response to acid chemical 2/308 80/18722 0.3800206788022 0.522626213846777 KLF2/CEBPB 2 GO:0009755 hormone-mediated signaling pathway 4/308 190/18722 0.381266866889763 0.522626213846777 YWHAH/PTGES3/DNAJA1/DDX5 4 GO:0015849 organic acid transport 6/308 303/18722 0.381282753030406 0.522626213846777 SNCA/MPC2/PLIN2/IL1B/APOE/ANXA1 6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 1/308 29/18722 0.382092667460565 0.522626213846777 ZFP36 1 GO:0001773 myeloid dendritic cell activation 1/308 29/18722 0.382092667460565 0.522626213846777 HMGB1 1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 1/308 29/18722 0.382092667460565 0.522626213846777 HLA-DRB1 1 GO:0006734 NADH metabolic process 1/308 29/18722 0.382092667460565 0.522626213846777 HK2 1 GO:0007143 female meiotic nuclear division 1/308 29/18722 0.382092667460565 0.522626213846777 UBB 1 GO:0009310 amine catabolic process 1/308 29/18722 0.382092667460565 0.522626213846777 COMT 1 GO:0010592 positive regulation of lamellipodium assembly 1/308 29/18722 0.382092667460565 0.522626213846777 RAC1 1 GO:0021591 ventricular system development 1/308 29/18722 0.382092667460565 0.522626213846777 ANP32B 1 GO:0021602 cranial nerve morphogenesis 1/308 29/18722 0.382092667460565 0.522626213846777 MAFB 1 GO:0030970 retrograde protein transport, ER to cytosol 1/308 29/18722 0.382092667460565 0.522626213846777 HERPUD1 1 GO:0032372 negative regulation of sterol transport 1/308 29/18722 0.382092667460565 0.522626213846777 APOC1 1 GO:0032375 negative regulation of cholesterol transport 1/308 29/18722 0.382092667460565 0.522626213846777 APOC1 1 GO:0033028 myeloid cell apoptotic process 1/308 29/18722 0.382092667460565 0.522626213846777 ANXA1 1 GO:0034311 diol metabolic process 1/308 29/18722 0.382092667460565 0.522626213846777 ASAH1 1 GO:0035066 positive regulation of histone acetylation 1/308 29/18722 0.382092667460565 0.522626213846777 IL1B 1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1/308 29/18722 0.382092667460565 0.522626213846777 EGFR 1 GO:0048265 response to pain 1/308 29/18722 0.382092667460565 0.522626213846777 COMT 1 GO:0048679 regulation of axon regeneration 1/308 29/18722 0.382092667460565 0.522626213846777 KLF4 1 GO:0051654 establishment of mitochondrion localization 1/308 29/18722 0.382092667460565 0.522626213846777 UBB 1 GO:0060441 epithelial tube branching involved in lung morphogenesis 1/308 29/18722 0.382092667460565 0.522626213846777 CTSH 1 GO:0060969 negative regulation of gene silencing 1/308 29/18722 0.382092667460565 0.522626213846777 NEAT1 1 GO:0070979 protein K11-linked ubiquitination 1/308 29/18722 0.382092667460565 0.522626213846777 UBE2B 1 GO:0072539 T-helper 17 cell differentiation 1/308 29/18722 0.382092667460565 0.522626213846777 NFKBIZ 1 GO:0095500 acetylcholine receptor signaling pathway 1/308 29/18722 0.382092667460565 0.522626213846777 LY6E 1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/308 29/18722 0.382092667460565 0.522626213846777 BID 1 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1/308 29/18722 0.382092667460565 0.522626213846777 UBB 1 GO:1902430 negative regulation of amyloid-beta formation 1/308 29/18722 0.382092667460565 0.522626213846777 APOE 1 GO:1903513 endoplasmic reticulum to cytosol transport 1/308 29/18722 0.382092667460565 0.522626213846777 HERPUD1 1 GO:2000406 positive regulation of T cell migration 1/308 29/18722 0.382092667460565 0.522626213846777 CXCL10 1 GO:0007409 axonogenesis 8/308 418/18722 0.382507352947133 0.523006298396598 HSP90AB1/RAB8A/NR4A2/RAC1/APOE/FN1/HSP90AA1/S100A6 8 GO:0042157 lipoprotein metabolic process 3/308 135/18722 0.383575222685566 0.524278897506942 APOL6/APOE/APOC1 3 GO:0006164 purine nucleotide biosynthetic process 4/308 191/18722 0.38499200364552 0.526027315917377 SNCA/TMSB4X/MPC2/ALDOA 4 GO:0014032 neural crest cell development 2/308 81/18722 0.385874613780245 0.526480602598815 FN1/HES1 2 GO:0044773 mitotic DNA damage checkpoint signaling 2/308 81/18722 0.385874613780245 0.526480602598815 SYF2/RPS27L 2 GO:2000106 regulation of leukocyte apoptotic process 2/308 81/18722 0.385874613780245 0.526480602598815 TSC22D3/ANXA1 2 GO:2000243 positive regulation of reproductive process 2/308 81/18722 0.385874613780245 0.526480602598815 UBE2B/DEFB1 2 GO:0007272 ensheathment of neurons 3/308 136/18722 0.388027204106848 0.52775887652083 CXCR4/TYMP/CD9 3 GO:0008366 axon ensheathment 3/308 136/18722 0.388027204106848 0.52775887652083 CXCR4/TYMP/CD9 3 GO:0072073 kidney epithelium development 3/308 136/18722 0.388027204106848 0.52775887652083 BASP1/STAT1/HES1 3 GO:0098876 vesicle-mediated transport to the plasma membrane 3/308 136/18722 0.388027204106848 0.52775887652083 VAMP2/RAB8A/SNX3 3 GO:1900180 regulation of protein localization to nucleus 3/308 136/18722 0.388027204106848 0.52775887652083 HSP90AB1/LARP7/NPM1 3 GO:1901988 negative regulation of cell cycle phase transition 5/308 249/18722 0.390235954582509 0.52775887652083 KLF4/DUSP1/SYF2/IK/RPS27L 5 GO:0009205 purine ribonucleoside triphosphate metabolic process 2/308 82/18722 0.39170442690965 0.52775887652083 TMSB4X/ALDOA 2 GO:2001252 positive regulation of chromosome organization 2/308 82/18722 0.39170442690965 0.52775887652083 HNRNPA1/PKIB 2 GO:0006099 tricarboxylic acid cycle 1/308 30/18722 0.392273775812469 0.52775887652083 SDHD 1 GO:0006884 cell volume homeostasis 1/308 30/18722 0.392273775812469 0.52775887652083 NPM1 1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/308 30/18722 0.392273775812469 0.52775887652083 DNASE2 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/308 30/18722 0.392273775812469 0.52775887652083 NCF1 1 GO:0007202 activation of phospholipase C activity 1/308 30/18722 0.392273775812469 0.52775887652083 EGFR 1 GO:0009264 deoxyribonucleotide catabolic process 1/308 30/18722 0.392273775812469 0.52775887652083 TYMP 1 GO:0010453 regulation of cell fate commitment 1/308 30/18722 0.392273775812469 0.52775887652083 HES1 1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 1/308 30/18722 0.392273775812469 0.52775887652083 CALM1 1 GO:0031571 mitotic G1 DNA damage checkpoint signaling 1/308 30/18722 0.392273775812469 0.52775887652083 RPS27L 1 GO:0032480 negative regulation of type I interferon production 1/308 30/18722 0.392273775812469 0.52775887652083 NMI 1 GO:0033137 negative regulation of peptidyl-serine phosphorylation 1/308 30/18722 0.392273775812469 0.52775887652083 DDIT4 1 GO:0034390 smooth muscle cell apoptotic process 1/308 30/18722 0.392273775812469 0.52775887652083 SOD2 1 GO:0034391 regulation of smooth muscle cell apoptotic process 1/308 30/18722 0.392273775812469 0.52775887652083 SOD2 1 GO:0034694 response to prostaglandin 1/308 30/18722 0.392273775812469 0.52775887652083 PTGER4 1 GO:0045070 positive regulation of viral genome replication 1/308 30/18722 0.392273775812469 0.52775887652083 IFIT1 1 GO:0045939 negative regulation of steroid metabolic process 1/308 30/18722 0.392273775812469 0.52775887652083 APOE 1 GO:0045948 positive regulation of translational initiation 1/308 30/18722 0.392273775812469 0.52775887652083 PPP1R15A 1 GO:0048147 negative regulation of fibroblast proliferation 1/308 30/18722 0.392273775812469 0.52775887652083 NUPR1 1 GO:0048240 sperm capacitation 1/308 30/18722 0.392273775812469 0.52775887652083 DEFB1 1 GO:0051491 positive regulation of filopodium assembly 1/308 30/18722 0.392273775812469 0.52775887652083 RALA 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/308 30/18722 0.392273775812469 0.52775887652083 EGFR 1 GO:0070229 negative regulation of lymphocyte apoptotic process 1/308 30/18722 0.392273775812469 0.52775887652083 TSC22D3 1 GO:0140058 neuron projection arborization 1/308 30/18722 0.392273775812469 0.52775887652083 PHACTR1 1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 1/308 30/18722 0.392273775812469 0.52775887652083 PPP1R15A 1 GO:1902751 positive regulation of cell cycle G2/M phase transition 1/308 30/18722 0.392273775812469 0.52775887652083 NPM1 1 GO:2000648 positive regulation of stem cell proliferation 1/308 30/18722 0.392273775812469 0.52775887652083 HNRNPU 1 GO:0001935 endothelial cell proliferation 4/308 193/18722 0.392434040080975 0.52775887652083 HMGB2/STAT1/APOE/HMGB1 4 GO:0000086 G2/M transition of mitotic cell cycle 3/308 137/18722 0.392471484684468 0.52775887652083 ENSA/SYF2/CALM1 3 GO:0007266 Rho protein signal transduction 3/308 137/18722 0.392471484684468 0.52775887652083 RHOB/RAC1/APOE 3 GO:0010977 negative regulation of neuron projection development 3/308 137/18722 0.392471484684468 0.52775887652083 B2M/APOE/LGALS1 3 GO:0030879 mammary gland development 3/308 137/18722 0.392471484684468 0.52775887652083 CEBPB/HK2/OAS2 3 GO:0034754 cellular hormone metabolic process 3/308 137/18722 0.392471484684468 0.52775887652083 SCPEP1/COMT/EGR1 3 GO:0055123 digestive system development 3/308 137/18722 0.392471484684468 0.52775887652083 CXCL8/EGFR/HES1 3 GO:0001539 cilium or flagellum-dependent cell motility 3/308 138/18722 0.396907590467653 0.533348934396427 UBE2B/DNAJA1/DEFB1 3 GO:0060285 cilium-dependent cell motility 3/308 138/18722 0.396907590467653 0.533348934396427 UBE2B/DNAJA1/DEFB1 3 GO:0048678 response to axon injury 2/308 83/18722 0.397509327495799 0.53378228275955 KLF4/LGALS1 2 GO:0050672 negative regulation of lymphocyte proliferation 2/308 83/18722 0.397509327495799 0.53378228275955 HLA-DRB1/CEBPB 2 GO:0002323 natural killer cell activation involved in immune response 1/308 31/18722 0.402287668228999 0.535310043731104 HLA-F 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/308 31/18722 0.402287668228999 0.535310043731104 HLA-F 1 GO:0006301 postreplication repair 1/308 31/18722 0.402287668228999 0.535310043731104 UBE2B 1 GO:0007190 activation of adenylate cyclase activity 1/308 31/18722 0.402287668228999 0.535310043731104 CALM1 1 GO:0008045 motor neuron axon guidance 1/308 31/18722 0.402287668228999 0.535310043731104 RAC1 1 GO:0016577 histone demethylation 1/308 31/18722 0.402287668228999 0.535310043731104 UBE2B 1 GO:0030149 sphingolipid catabolic process 1/308 31/18722 0.402287668228999 0.535310043731104 ASAH1 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/308 31/18722 0.402287668228999 0.535310043731104 APOBEC3A 1 GO:0035510 DNA dealkylation 1/308 31/18722 0.402287668228999 0.535310043731104 APOBEC3A 1 GO:0036475 neuron death in response to oxidative stress 1/308 31/18722 0.402287668228999 0.535310043731104 MCL1 1 GO:0042133 neurotransmitter metabolic process 1/308 31/18722 0.402287668228999 0.535310043731104 COMT 1 GO:0043171 peptide catabolic process 1/308 31/18722 0.402287668228999 0.535310043731104 CTSH 1 GO:0044819 mitotic G1/S transition checkpoint signaling 1/308 31/18722 0.402287668228999 0.535310043731104 RPS27L 1 GO:0046386 deoxyribose phosphate catabolic process 1/308 31/18722 0.402287668228999 0.535310043731104 TYMP 1 GO:0048384 retinoic acid receptor signaling pathway 1/308 31/18722 0.402287668228999 0.535310043731104 KLF2 1 GO:0048566 embryonic digestive tract development 1/308 31/18722 0.402287668228999 0.535310043731104 CXCL8 1 GO:0048710 regulation of astrocyte differentiation 1/308 31/18722 0.402287668228999 0.535310043731104 HES1 1 GO:0050482 arachidonic acid secretion 1/308 31/18722 0.402287668228999 0.535310043731104 ANXA1 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/308 31/18722 0.402287668228999 0.535310043731104 KLF4 1 GO:0070528 protein kinase C signaling 1/308 31/18722 0.402287668228999 0.535310043731104 MYADM 1 GO:0070723 response to cholesterol 1/308 31/18722 0.402287668228999 0.535310043731104 CCL3 1 GO:0071480 cellular response to gamma radiation 1/308 31/18722 0.402287668228999 0.535310043731104 EGR1 1 GO:0090162 establishment of epithelial cell polarity 1/308 31/18722 0.402287668228999 0.535310043731104 HES1 1 GO:1903963 arachidonate transport 1/308 31/18722 0.402287668228999 0.535310043731104 ANXA1 1 GO:1905144 response to acetylcholine 1/308 31/18722 0.402287668228999 0.535310043731104 LY6E 1 GO:1905145 cellular response to acetylcholine 1/308 31/18722 0.402287668228999 0.535310043731104 LY6E 1 GO:0060828 regulation of canonical Wnt signaling pathway 5/308 253/18722 0.403261409814781 0.535523499193995 UBE2B/EGR1/RPS12/EGFR/APOE 5 GO:0010660 regulation of muscle cell apoptotic process 2/308 84/18722 0.403288557201023 0.535523499193995 NUPR1/SOD2 2 GO:0015844 monoamine transport 2/308 84/18722 0.403288557201023 0.535523499193995 SNCA/LY6E 2 GO:0032508 DNA duplex unwinding 2/308 84/18722 0.403288557201023 0.535523499193995 CHD2/ANXA1 2 GO:0032945 negative regulation of mononuclear cell proliferation 2/308 84/18722 0.403288557201023 0.535523499193995 HLA-DRB1/CEBPB 2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 2/308 84/18722 0.403288557201023 0.535523499193995 KLF4/RPS27L 2 GO:0031032 actomyosin structure organization 4/308 196/18722 0.403571902473202 0.535713674706615 PTGER4/PHACTR1/KRT8/RAC1 4 GO:0015748 organophosphate ester transport 3/308 140/18722 0.405753430321703 0.538422549156498 PLSCR1/APOE/APOC1 3 GO:0009142 nucleoside triphosphate biosynthetic process 2/308 85/18722 0.409041389200112 0.541657509841368 TMSB4X/ALDOA 2 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 2/308 85/18722 0.409041389200112 0.541657509841368 SOCS3/HES1 2 GO:0044774 mitotic DNA integrity checkpoint signaling 2/308 85/18722 0.409041389200112 0.541657509841368 SYF2/RPS27L 2 GO:0055072 iron ion homeostasis 2/308 85/18722 0.409041389200112 0.541657509841368 B2M/SRI 2 GO:0097006 regulation of plasma lipoprotein particle levels 2/308 85/18722 0.409041389200112 0.541657509841368 APOE/APOC1 2 GO:0097194 execution phase of apoptosis 2/308 85/18722 0.409041389200112 0.541657509841368 PLSCR1/DNASE2 2 GO:0050864 regulation of B cell activation 4/308 198/18722 0.410976864876116 0.542748903061935 TNFAIP3/GPR183/TNFSF13B/LAPTM5 4 GO:0006308 DNA catabolic process 1/308 32/18722 0.412137082288464 0.542748903061935 DNASE2 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/308 32/18722 0.412137082288464 0.542748903061935 NUPR1 1 GO:0010743 regulation of macrophage derived foam cell differentiation 1/308 32/18722 0.412137082288464 0.542748903061935 NFKBIA 1 GO:0019934 cGMP-mediated signaling 1/308 32/18722 0.412137082288464 0.542748903061935 APOE 1 GO:0030431 sleep 1/308 32/18722 0.412137082288464 0.542748903061935 FOS 1 GO:0032196 transposition 1/308 32/18722 0.412137082288464 0.542748903061935 APOBEC3A 1 GO:0035883 enteroendocrine cell differentiation 1/308 32/18722 0.412137082288464 0.542748903061935 HES1 1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1/308 32/18722 0.412137082288464 0.542748903061935 TNFAIP3 1 GO:0046475 glycerophospholipid catabolic process 1/308 32/18722 0.412137082288464 0.542748903061935 APOC1 1 GO:0060914 heart formation 1/308 32/18722 0.412137082288464 0.542748903061935 HES1 1 GO:0090140 regulation of mitochondrial fission 1/308 32/18722 0.412137082288464 0.542748903061935 RALA 1 GO:1901185 negative regulation of ERBB signaling pathway 1/308 32/18722 0.412137082288464 0.542748903061935 EGFR 1 GO:1901889 negative regulation of cell junction assembly 1/308 32/18722 0.412137082288464 0.542748903061935 IL1B 1 GO:1905476 negative regulation of protein localization to membrane 1/308 32/18722 0.412137082288464 0.542748903061935 GBP1 1 GO:2000191 regulation of fatty acid transport 1/308 32/18722 0.412137082288464 0.542748903061935 IL1B 1 GO:0014031 mesenchymal cell development 2/308 86/18722 0.414767127354692 0.545085846640422 FN1/HES1 2 GO:0034103 regulation of tissue remodeling 2/308 86/18722 0.414767127354692 0.545085846640422 TNFAIP3/EGFR 2 GO:0035023 regulation of Rho protein signal transduction 2/308 86/18722 0.414767127354692 0.545085846640422 RAC1/APOE 2 GO:0046928 regulation of neurotransmitter secretion 2/308 86/18722 0.414767127354692 0.545085846640422 SNCA/CALM1 2 GO:0048864 stem cell development 2/308 86/18722 0.414767127354692 0.545085846640422 FN1/HES1 2 GO:1903510 mucopolysaccharide metabolic process 2/308 86/18722 0.414767127354692 0.545085846640422 IL1B/ITIH5 2 GO:0018105 peptidyl-serine phosphorylation 6/308 315/18722 0.416470534834333 0.547136376175826 SNCA/DDIT4/HSP90AB1/EGFR/SGK1/HSP90AA1 6 GO:0072522 purine-containing compound biosynthetic process 4/308 200/18722 0.418362900701226 0.549075883469996 SNCA/TMSB4X/MPC2/ALDOA 4 GO:0099003 vesicle-mediated transport in synapse 4/308 200/18722 0.418362900701226 0.549075883469996 SNCA/VAMP2/RAB8A/CALM1 4 GO:0030010 establishment of cell polarity 3/308 143/18722 0.418949585206454 0.549075883469996 HSP90AB1/HSP90AA1/HES1 3 GO:0016101 diterpenoid metabolic process 2/308 87/18722 0.420465105406103 0.549075883469996 SCPEP1/EGFR 2 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/308 33/18722 0.421824710894946 0.549075883469996 PLSCR1 1 GO:0006482 protein demethylation 1/308 33/18722 0.421824710894946 0.549075883469996 UBE2B 1 GO:0006891 intra-Golgi vesicle-mediated transport 1/308 33/18722 0.421824710894946 0.549075883469996 GABARAPL2 1 GO:0008214 protein dealkylation 1/308 33/18722 0.421824710894946 0.549075883469996 UBE2B 1 GO:0010165 response to X-ray 1/308 33/18722 0.421824710894946 0.549075883469996 ANXA1 1 GO:0010984 regulation of lipoprotein particle clearance 1/308 33/18722 0.421824710894946 0.549075883469996 APOC1 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/308 33/18722 0.421824710894946 0.549075883469996 IL1B 1 GO:0033198 response to ATP 1/308 33/18722 0.421824710894946 0.549075883469996 CASP1 1 GO:0035025 positive regulation of Rho protein signal transduction 1/308 33/18722 0.421824710894946 0.549075883469996 RAC1 1 GO:0040020 regulation of meiotic nuclear division 1/308 33/18722 0.421824710894946 0.549075883469996 UBE2B 1 GO:0048333 mesodermal cell differentiation 1/308 33/18722 0.421824710894946 0.549075883469996 KLF4 1 GO:0048730 epidermis morphogenesis 1/308 33/18722 0.421824710894946 0.549075883469996 KLF4 1 GO:0050974 detection of mechanical stimulus involved in sensory perception 1/308 33/18722 0.421824710894946 0.549075883469996 CXCR4 1 GO:0060122 inner ear receptor cell stereocilium organization 1/308 33/18722 0.421824710894946 0.549075883469996 HES1 1 GO:0070570 regulation of neuron projection regeneration 1/308 33/18722 0.421824710894946 0.549075883469996 KLF4 1 GO:0099174 regulation of presynapse organization 1/308 33/18722 0.421824710894946 0.549075883469996 SNCA 1 GO:0150117 positive regulation of cell-substrate junction organization 1/308 33/18722 0.421824710894946 0.549075883469996 RAC1 1 GO:1901976 regulation of cell cycle checkpoint 1/308 33/18722 0.421824710894946 0.549075883469996 DUSP1 1 GO:1902275 regulation of chromatin organization 1/308 33/18722 0.421824710894946 0.549075883469996 HNRNPU 1 GO:1902992 negative regulation of amyloid precursor protein catabolic process 1/308 33/18722 0.421824710894946 0.549075883469996 APOE 1 GO:1903146 regulation of autophagy of mitochondrion 1/308 33/18722 0.421824710894946 0.549075883469996 BNIP3L 1 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 1/308 33/18722 0.421824710894946 0.549075883469996 TNFAIP3 1 GO:1905606 regulation of presynapse assembly 1/308 33/18722 0.421824710894946 0.549075883469996 SNCA 1 GO:0006473 protein acetylation 4/308 201/18722 0.422048117214037 0.549179697790764 SNCA/NUPR1/IL1B/SET 4 GO:0007612 learning 3/308 144/18722 0.423327228454076 0.550469385843515 JUN/FOS/COMT 3 GO:0031644 regulation of nervous system process 3/308 144/18722 0.423327228454076 0.550469385843515 CCL3/COMT/TYMP 3 GO:0016051 carbohydrate biosynthetic process 4/308 202/18722 0.425727765440808 0.55336715532966 SNCA/ATF3/PTGES3/ISYNA1 4 GO:0007260 tyrosine phosphorylation of STAT protein 2/308 88/18722 0.426134686186377 0.55336715532966 SOCS3/HES1 2 GO:0009144 purine nucleoside triphosphate metabolic process 2/308 88/18722 0.426134686186377 0.55336715532966 TMSB4X/ALDOA 2 GO:0030101 natural killer cell activation 2/308 88/18722 0.426134686186377 0.55336715532966 HLA-F/PRDX1 2 GO:0007269 neurotransmitter secretion 3/308 145/18722 0.42769364746899 0.555014533018991 SNCA/VAMP2/CALM1 3 GO:0099643 signal release from synapse 3/308 145/18722 0.42769364746899 0.555014533018991 SNCA/VAMP2/CALM1 3 GO:0001662 behavioral fear response 1/308 34/18722 0.431353203004976 0.556345406881669 APOE 1 GO:0006356 regulation of transcription by RNA polymerase I 1/308 34/18722 0.431353203004976 0.556345406881669 NCL 1 GO:0007095 mitotic G2 DNA damage checkpoint signaling 1/308 34/18722 0.431353203004976 0.556345406881669 SYF2 1 GO:0009112 nucleobase metabolic process 1/308 34/18722 0.431353203004976 0.556345406881669 TYMP 1 GO:0009303 rRNA transcription 1/308 34/18722 0.431353203004976 0.556345406881669 NCL 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/308 34/18722 0.431353203004976 0.556345406881669 SOD2 1 GO:0016242 negative regulation of macroautophagy 1/308 34/18722 0.431353203004976 0.556345406881669 NUPR1 1 GO:0019320 hexose catabolic process 1/308 34/18722 0.431353203004976 0.556345406881669 HK2 1 GO:0035909 aorta morphogenesis 1/308 34/18722 0.431353203004976 0.556345406881669 HES1 1 GO:0042573 retinoic acid metabolic process 1/308 34/18722 0.431353203004976 0.556345406881669 SCPEP1 1 GO:0043276 anoikis 1/308 34/18722 0.431353203004976 0.556345406881669 MCL1 1 GO:0070232 regulation of T cell apoptotic process 1/308 34/18722 0.431353203004976 0.556345406881669 TSC22D3 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/308 34/18722 0.431353203004976 0.556345406881669 CAMTA1 1 GO:0090075 relaxation of muscle 1/308 34/18722 0.431353203004976 0.556345406881669 SRI 1 GO:0098751 bone cell development 1/308 34/18722 0.431353203004976 0.556345406881669 FBN1 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/308 34/18722 0.431353203004976 0.556345406881669 SOCS3 1 GO:2000352 negative regulation of endothelial cell apoptotic process 1/308 34/18722 0.431353203004976 0.556345406881669 TNFAIP3 1 GO:2000758 positive regulation of peptidyl-lysine acetylation 1/308 34/18722 0.431353203004976 0.556345406881669 IL1B 1 GO:0009199 ribonucleoside triphosphate metabolic process 2/308 89/18722 0.431775260846955 0.556345406881669 TMSB4X/ALDOA 2 GO:0010657 muscle cell apoptotic process 2/308 89/18722 0.431775260846955 0.556345406881669 NUPR1/SOD2 2 GO:1900407 regulation of cellular response to oxidative stress 2/308 89/18722 0.431775260846955 0.556345406881669 SOD2/MCL1 2 GO:0030900 forebrain development 7/308 379/18722 0.432056208818446 0.556519840401927 B2M/CXCR4/PHACTR1/BCL2A1/NR4A2/UBB/HES1 7 GO:0003018 vascular process in circulatory system 5/308 263/18722 0.435658944332355 0.560971419394609 KLF2/SCPEP1/SOD2/EGFR/APOE 5 GO:0097581 lamellipodium organization 2/308 90/18722 0.437386248104775 0.5621929607211 SNX2/RAC1 2 GO:0099175 regulation of postsynapse organization 2/308 90/18722 0.437386248104775 0.5621929607211 SRGN/APOE 2 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 2/308 90/18722 0.437386248104775 0.5621929607211 JUN/SOD2 2 GO:0002209 behavioral defense response 1/308 35/18722 0.440725164342437 0.5621929607211 APOE 1 GO:0006084 acetyl-CoA metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 MPC2 1 GO:0006298 mismatch repair 1/308 35/18722 0.440725164342437 0.5621929607211 HMGB1 1 GO:0006739 NADP metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 TKT 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/308 35/18722 0.440725164342437 0.5621929607211 HNRNPU 1 GO:0009119 ribonucleoside metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 APOBEC3A 1 GO:0010664 negative regulation of striated muscle cell apoptotic process 1/308 35/18722 0.440725164342437 0.5621929607211 NUPR1 1 GO:0010765 positive regulation of sodium ion transport 1/308 35/18722 0.440725164342437 0.5621929607211 GLRX 1 GO:0010837 regulation of keratinocyte proliferation 1/308 35/18722 0.440725164342437 0.5621929607211 ZFP36 1 GO:0032350 regulation of hormone metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 EGR1 1 GO:0032814 regulation of natural killer cell activation 1/308 35/18722 0.440725164342437 0.5621929607211 HLA-F 1 GO:0033280 response to vitamin D 1/308 35/18722 0.440725164342437 0.5621929607211 CXCL10 1 GO:0045907 positive regulation of vasoconstriction 1/308 35/18722 0.440725164342437 0.5621929607211 EGFR 1 GO:0045922 negative regulation of fatty acid metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 APOC1 1 GO:0046640 regulation of alpha-beta T cell proliferation 1/308 35/18722 0.440725164342437 0.5621929607211 HLA-A 1 GO:0048821 erythrocyte development 1/308 35/18722 0.440725164342437 0.5621929607211 KLF2 1 GO:0071108 protein K48-linked deubiquitination 1/308 35/18722 0.440725164342437 0.5621929607211 TNFAIP3 1 GO:0086005 ventricular cardiac muscle cell action potential 1/308 35/18722 0.440725164342437 0.5621929607211 DSP 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/308 35/18722 0.440725164342437 0.5621929607211 ANXA1 1 GO:0090181 regulation of cholesterol metabolic process 1/308 35/18722 0.440725164342437 0.5621929607211 APOE 1 GO:0098801 regulation of renal system process 1/308 35/18722 0.440725164342437 0.5621929607211 COMT 1 GO:0098810 neurotransmitter reuptake 1/308 35/18722 0.440725164342437 0.5621929607211 SNCA 1 GO:0106056 regulation of calcineurin-mediated signaling 1/308 35/18722 0.440725164342437 0.5621929607211 CAMTA1 1 GO:1905207 regulation of cardiocyte differentiation 1/308 35/18722 0.440725164342437 0.5621929607211 EGFR 1 GO:1905898 positive regulation of response to endoplasmic reticulum stress 1/308 35/18722 0.440725164342437 0.5621929607211 HERPUD1 1 GO:0001657 ureteric bud development 2/308 91/18722 0.442967093505349 0.563736084710702 BASP1/HES1 2 GO:0002065 columnar/cuboidal epithelial cell differentiation 2/308 91/18722 0.442967093505349 0.563736084710702 CEBPB/HES1 2 GO:0006354 DNA-templated transcription, elongation 2/308 91/18722 0.442967093505349 0.563736084710702 LARP7/HNRNPU 2 GO:0014033 neural crest cell differentiation 2/308 91/18722 0.442967093505349 0.563736084710702 FN1/HES1 2 GO:0051492 regulation of stress fiber assembly 2/308 91/18722 0.442967093505349 0.563736084710702 PTGER4/RAC1 2 GO:0072080 nephron tubule development 2/308 91/18722 0.442967093505349 0.563736084710702 STAT1/HES1 2 GO:1990874 vascular associated smooth muscle cell proliferation 2/308 91/18722 0.442967093505349 0.563736084710702 JUN/SOD2 2 GO:0050679 positive regulation of epithelial cell proliferation 4/308 207/18722 0.444033157736838 0.564904746099145 HMGB2/TNFAIP3/EGFR/HMGB1 4 GO:0060562 epithelial tube morphogenesis 6/308 325/18722 0.445631502001015 0.566749578226839 RHOB/RALA/CXCR4/CTSH/HES1/CXCL10 6 GO:0072163 mesonephric epithelium development 2/308 92/18722 0.448517268702519 0.567700558885627 BASP1/HES1 2 GO:0072164 mesonephric tubule development 2/308 92/18722 0.448517268702519 0.567700558885627 BASP1/HES1 2 GO:0002691 regulation of cellular extravasation 1/308 36/18722 0.44994315810187 0.567700558885627 PTGER4 1 GO:0003352 regulation of cilium movement 1/308 36/18722 0.44994315810187 0.567700558885627 DEFB1 1 GO:0008207 C21-steroid hormone metabolic process 1/308 36/18722 0.44994315810187 0.567700558885627 EGR1 1 GO:0010762 regulation of fibroblast migration 1/308 36/18722 0.44994315810187 0.567700558885627 RAC1 1 GO:0010923 negative regulation of phosphatase activity 1/308 36/18722 0.44994315810187 0.567700558885627 PPP1R15A 1 GO:0014046 dopamine secretion 1/308 36/18722 0.44994315810187 0.567700558885627 SNCA 1 GO:0014059 regulation of dopamine secretion 1/308 36/18722 0.44994315810187 0.567700558885627 SNCA 1 GO:0036314 response to sterol 1/308 36/18722 0.44994315810187 0.567700558885627 CCL3 1 GO:0038179 neurotrophin signaling pathway 1/308 36/18722 0.44994315810187 0.567700558885627 DDIT4 1 GO:0042119 neutrophil activation 1/308 36/18722 0.44994315810187 0.567700558885627 CXCL8 1 GO:0043949 regulation of cAMP-mediated signaling 1/308 36/18722 0.44994315810187 0.567700558885627 UBE2B 1 GO:0045652 regulation of megakaryocyte differentiation 1/308 36/18722 0.44994315810187 0.567700558885627 HMGB2 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/308 36/18722 0.44994315810187 0.567700558885627 NCF1 1 GO:0045746 negative regulation of Notch signaling pathway 1/308 36/18722 0.44994315810187 0.567700558885627 NFKBIA 1 GO:0046466 membrane lipid catabolic process 1/308 36/18722 0.44994315810187 0.567700558885627 ASAH1 1 GO:0051354 negative regulation of oxidoreductase activity 1/308 36/18722 0.44994315810187 0.567700558885627 SNCA 1 GO:0051955 regulation of amino acid transport 1/308 36/18722 0.44994315810187 0.567700558885627 SNCA 1 GO:0070897 transcription preinitiation complex assembly 1/308 36/18722 0.44994315810187 0.567700558885627 HMGB1 1 GO:0086010 membrane depolarization during action potential 1/308 36/18722 0.44994315810187 0.567700558885627 YWHAH 1 GO:0090322 regulation of superoxide metabolic process 1/308 36/18722 0.44994315810187 0.567700558885627 EGFR 1 GO:1901658 glycosyl compound catabolic process 1/308 36/18722 0.44994315810187 0.567700558885627 APOBEC3A 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/308 36/18722 0.44994315810187 0.567700558885627 BID 1 GO:1901992 positive regulation of mitotic cell cycle phase transition 2/308 93/18722 0.454036270754503 0.572487026086564 EGFR/ANXA1 2 GO:1902807 negative regulation of cell cycle G1/S phase transition 2/308 93/18722 0.454036270754503 0.572487026086564 KLF4/RPS27L 2 GO:0016573 histone acetylation 3/308 152/18722 0.457912001918285 0.576287062286759 SNCA/IL1B/SET 3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1/308 37/18722 0.459009705640382 0.576287062286759 EIF3E 1 GO:0006904 vesicle docking involved in exocytosis 1/308 37/18722 0.459009705640382 0.576287062286759 RAB8A 1 GO:0021532 neural tube patterning 1/308 37/18722 0.459009705640382 0.576287062286759 HES1 1 GO:0030513 positive regulation of BMP signaling pathway 1/308 37/18722 0.459009705640382 0.576287062286759 HES1 1 GO:0033363 secretory granule organization 1/308 37/18722 0.459009705640382 0.576287062286759 SRGN 1 GO:0043029 T cell homeostasis 1/308 37/18722 0.459009705640382 0.576287062286759 TSC22D3 1 GO:0045616 regulation of keratinocyte differentiation 1/308 37/18722 0.459009705640382 0.576287062286759 ZFP36 1 GO:0060416 response to growth hormone 1/308 37/18722 0.459009705640382 0.576287062286759 CACYBP 1 GO:0060428 lung epithelium development 1/308 37/18722 0.459009705640382 0.576287062286759 KLF2 1 GO:0071542 dopaminergic neuron differentiation 1/308 37/18722 0.459009705640382 0.576287062286759 NR4A2 1 GO:0097484 dendrite extension 1/308 37/18722 0.459009705640382 0.576287062286759 CXCR4 1 GO:1902745 positive regulation of lamellipodium organization 1/308 37/18722 0.459009705640382 0.576287062286759 RAC1 1 GO:0002042 cell migration involved in sprouting angiogenesis 2/308 94/18722 0.459523621435921 0.576364437253782 KLF4/ANXA1 2 GO:0061326 renal tubule development 2/308 94/18722 0.459523621435921 0.576364437253782 STAT1/HES1 2 GO:1903035 negative regulation of response to wounding 2/308 94/18722 0.459523621435921 0.576364437253782 APOE/CD9 2 GO:0006631 fatty acid metabolic process 7/308 390/18722 0.461419603886201 0.578552687981944 SNCA/IL1B/PTGES3/CBR1/ASAH1/ANXA1/APOC1 7 GO:0007338 single fertilization 3/308 153/18722 0.462175052931146 0.579120035187077 VDAC2/ALDOA/CD9 3 GO:0120254 olefinic compound metabolic process 3/308 153/18722 0.462175052931146 0.579120035187077 PTGES3/EGR1/CBR1 3 GO:0007044 cell-substrate junction assembly 2/308 95/18722 0.464978866565455 0.581870444150486 RAC1/FN1 2 GO:0008593 regulation of Notch signaling pathway 2/308 95/18722 0.464978866565455 0.581870444150486 NFKBIA/HES1 2 GO:0030516 regulation of axon extension 2/308 95/18722 0.464978866565455 0.581870444150486 APOE/FN1 2 GO:0036473 cell death in response to oxidative stress 2/308 95/18722 0.464978866565455 0.581870444150486 SOD2/MCL1 2 GO:0001505 regulation of neurotransmitter levels 4/308 213/18722 0.465761927119188 0.58250928648853 SNCA/VAMP2/COMT/CALM1 4 GO:0003012 muscle system process 8/308 452/18722 0.467249926589339 0.58250928648853 KLF4/IL1B/CXCR4/SRI/DSP/ALDOA/CALM1/TPM3 8 GO:0000578 embryonic axis specification 1/308 38/18722 0.467927287158325 0.58250928648853 BASP1 1 GO:0008210 estrogen metabolic process 1/308 38/18722 0.467927287158325 0.58250928648853 COMT 1 GO:0032941 secretion by tissue 1/308 38/18722 0.467927287158325 0.58250928648853 EGFR 1 GO:0042491 inner ear auditory receptor cell differentiation 1/308 38/18722 0.467927287158325 0.58250928648853 HES1 1 GO:0042596 fear response 1/308 38/18722 0.467927287158325 0.58250928648853 APOE 1 GO:0046329 negative regulation of JNK cascade 1/308 38/18722 0.467927287158325 0.58250928648853 DNAJA1 1 GO:0046633 alpha-beta T cell proliferation 1/308 38/18722 0.467927287158325 0.58250928648853 HLA-A 1 GO:0048246 macrophage chemotaxis 1/308 38/18722 0.467927287158325 0.58250928648853 CCL3 1 GO:0071392 cellular response to estradiol stimulus 1/308 38/18722 0.467927287158325 0.58250928648853 EGFR 1 GO:0072538 T-helper 17 type immune response 1/308 38/18722 0.467927287158325 0.58250928648853 NFKBIZ 1 GO:0097242 amyloid-beta clearance 1/308 38/18722 0.467927287158325 0.58250928648853 APOE 1 GO:0098926 postsynaptic signal transduction 1/308 38/18722 0.467927287158325 0.58250928648853 LY6E 1 GO:1901186 positive regulation of ERBB signaling pathway 1/308 38/18722 0.467927287158325 0.58250928648853 NCF1 1 GO:1903725 regulation of phospholipid metabolic process 1/308 38/18722 0.467927287158325 0.58250928648853 APOC1 1 GO:0001823 mesonephros development 2/308 96/18722 0.47040157534882 0.584637588608108 BASP1/HES1 2 GO:0006637 acyl-CoA metabolic process 2/308 96/18722 0.47040157534882 0.584637588608108 SNCA/MPC2 2 GO:0030510 regulation of BMP signaling pathway 2/308 96/18722 0.47040157534882 0.584637588608108 FBN1/HES1 2 GO:0035282 segmentation 2/308 96/18722 0.47040157534882 0.584637588608108 BASP1/MAFB 2 GO:0035383 thioester metabolic process 2/308 96/18722 0.47040157534882 0.584637588608108 SNCA/MPC2 2 GO:0006606 protein import into nucleus 3/308 155/18722 0.470657381959569 0.584765411514927 NFKBIA/HSP90AB1/TXNIP 3 GO:0006721 terpenoid metabolic process 2/308 97/18722 0.475791339736733 0.590161192641346 SCPEP1/EGFR 2 GO:0070252 actin-mediated cell contraction 2/308 97/18722 0.475791339736733 0.590161192641346 SRI/DSP 2 GO:0120162 positive regulation of cold-induced thermogenesis 2/308 97/18722 0.475791339736733 0.590161192641346 CEBPB/CXCR4 2 GO:0001941 postsynaptic membrane organization 1/308 39/18722 0.476698342368945 0.590161192641346 APOE 1 GO:0010463 mesenchymal cell proliferation 1/308 39/18722 0.476698342368945 0.590161192641346 STAT1 1 GO:0016233 telomere capping 1/308 39/18722 0.476698342368945 0.590161192641346 PKIB 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/308 39/18722 0.476698342368945 0.590161192641346 BHLHE41 1 GO:0086091 regulation of heart rate by cardiac conduction 1/308 39/18722 0.476698342368945 0.590161192641346 DSP 1 GO:0090207 regulation of triglyceride metabolic process 1/308 39/18722 0.476698342368945 0.590161192641346 APOE 1 GO:2000249 regulation of actin cytoskeleton reorganization 1/308 39/18722 0.476698342368945 0.590161192641346 IQGAP2 1 GO:2000785 regulation of autophagosome assembly 1/308 39/18722 0.476698342368945 0.590161192641346 NUPR1 1 GO:0001837 epithelial to mesenchymal transition 3/308 157/18722 0.479079264023264 0.592533169317676 IL1B/SDCBP/DDX5 3 GO:0007030 Golgi organization 3/308 157/18722 0.479079264023264 0.592533169317676 RAB2A/GCC2/VMP1 3 GO:1990845 adaptive thermogenesis 3/308 157/18722 0.479079264023264 0.592533169317676 CEBPB/CXCR4/HNRNPU 3 GO:1902882 regulation of response to oxidative stress 2/308 98/18722 0.481147773797556 0.594899074782683 SOD2/MCL1 2 GO:0018209 peptidyl-serine modification 6/308 338/18722 0.483067474213938 0.597079519534395 SNCA/DDIT4/HSP90AB1/EGFR/SGK1/HSP90AA1 6 GO:0018393 internal peptidyl-lysine acetylation 3/308 158/18722 0.483266787453546 0.597132814620203 SNCA/IL1B/SET 3 GO:0009394 2'-deoxyribonucleotide metabolic process 1/308 40/18722 0.485325271157168 0.597167206834198 TYMP 1 GO:0010863 positive regulation of phospholipase C activity 1/308 40/18722 0.485325271157168 0.597167206834198 EGFR 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization 1/308 40/18722 0.485325271157168 0.597167206834198 SNCA 1 GO:0032892 positive regulation of organic acid transport 1/308 40/18722 0.485325271157168 0.597167206834198 IL1B 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/308 40/18722 0.485325271157168 0.597167206834198 TNFAIP3 1 GO:0043001 Golgi to plasma membrane protein transport 1/308 40/18722 0.485325271157168 0.597167206834198 VAMP2 1 GO:0044275 cellular carbohydrate catabolic process 1/308 40/18722 0.485325271157168 0.597167206834198 HMGB1 1 GO:0045022 early endosome to late endosome transport 1/308 40/18722 0.485325271157168 0.597167206834198 SNX3 1 GO:0046365 monosaccharide catabolic process 1/308 40/18722 0.485325271157168 0.597167206834198 HK2 1 GO:0060412 ventricular septum morphogenesis 1/308 40/18722 0.485325271157168 0.597167206834198 HES1 1 GO:0071526 semaphorin-plexin signaling pathway 1/308 40/18722 0.485325271157168 0.597167206834198 RAC1 1 GO:1901661 quinone metabolic process 1/308 40/18722 0.485325271157168 0.597167206834198 CBR1 1 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 1/308 40/18722 0.485325271157168 0.597167206834198 KLF4 1 GO:0002444 myeloid leukocyte mediated immunity 2/308 99/18722 0.486470513104316 0.597998961928553 CCL3/VAMP2 2 GO:0010717 regulation of epithelial to mesenchymal transition 2/308 99/18722 0.486470513104316 0.597998961928553 IL1B/SDCBP 2 GO:0042100 B cell proliferation 2/308 99/18722 0.486470513104316 0.597998961928553 GPR183/TNFSF13B 2 GO:0021700 developmental maturation 5/308 280/18722 0.489737300068309 0.601821182308307 KLF2/NR4A2/DEFB1/HES1/C1QA 5 GO:0006475 internal protein amino acid acetylation 3/308 160/18722 0.491593570465895 0.603142597254141 SNCA/IL1B/SET 3 GO:0006641 triglyceride metabolic process 2/308 100/18722 0.491759214135798 0.603142597254141 APOE/APOC1 2 GO:0044728 DNA methylation or demethylation 2/308 100/18722 0.491759214135798 0.603142597254141 FOS/APOBEC3A 2 GO:0051588 regulation of neurotransmitter transport 2/308 100/18722 0.491759214135798 0.603142597254141 SNCA/CALM1 2 GO:0060840 artery development 2/308 100/18722 0.491759214135798 0.603142597254141 APOE/HES1 2 GO:0110020 regulation of actomyosin structure organization 2/308 100/18722 0.491759214135798 0.603142597254141 PTGER4/RAC1 2 GO:0007099 centriole replication 1/308 41/18722 0.493810434227696 0.604301309235749 NPM1 1 GO:0010907 positive regulation of glucose metabolic process 1/308 41/18722 0.493810434227696 0.604301309235749 HMGB1 1 GO:0042307 positive regulation of protein import into nucleus 1/308 41/18722 0.493810434227696 0.604301309235749 HSP90AB1 1 GO:0048286 lung alveolus development 1/308 41/18722 0.493810434227696 0.604301309235749 PTGES3 1 GO:0060612 adipose tissue development 1/308 41/18722 0.493810434227696 0.604301309235749 UBB 1 GO:1902116 negative regulation of organelle assembly 1/308 41/18722 0.493810434227696 0.604301309235749 NUPR1 1 GO:2000008 regulation of protein localization to cell surface 1/308 41/18722 0.493810434227696 0.604301309235749 HSP90AB1 1 GO:0003205 cardiac chamber development 3/308 161/18722 0.495732282600865 0.606459045242595 LY6E/DSP/HES1 3 GO:0150115 cell-substrate junction organization 2/308 101/18722 0.497013553691414 0.60783199480559 RAC1/FN1 2 GO:0000266 mitochondrial fission 1/308 42/18722 0.502156153742597 0.608955798244744 RALA 1 GO:0010591 regulation of lamellipodium assembly 1/308 42/18722 0.502156153742597 0.608955798244744 RAC1 1 GO:0014003 oligodendrocyte development 1/308 42/18722 0.502156153742597 0.608955798244744 CD9 1 GO:0014912 negative regulation of smooth muscle cell migration 1/308 42/18722 0.502156153742597 0.608955798244744 TRIB1 1 GO:0016601 Rac protein signal transduction 1/308 42/18722 0.502156153742597 0.608955798244744 RAC1 1 GO:0019692 deoxyribose phosphate metabolic process 1/308 42/18722 0.502156153742597 0.608955798244744 TYMP 1 GO:0021575 hindbrain morphogenesis 1/308 42/18722 0.502156153742597 0.608955798244744 HES1 1 GO:0032691 negative regulation of interleukin-1 beta production 1/308 42/18722 0.502156153742597 0.608955798244744 TNFAIP3 1 GO:0033003 regulation of mast cell activation 1/308 42/18722 0.502156153742597 0.608955798244744 PLSCR1 1 GO:0033574 response to testosterone 1/308 42/18722 0.502156153742597 0.608955798244744 DUSP1 1 GO:0035019 somatic stem cell population maintenance 1/308 42/18722 0.502156153742597 0.608955798244744 HES1 1 GO:0042168 heme metabolic process 1/308 42/18722 0.502156153742597 0.608955798244744 BLVRA 1 GO:0045047 protein targeting to ER 1/308 42/18722 0.502156153742597 0.608955798244744 HERPUD1 1 GO:0045214 sarcomere organization 1/308 42/18722 0.502156153742597 0.608955798244744 KRT8 1 GO:0045773 positive regulation of axon extension 1/308 42/18722 0.502156153742597 0.608955798244744 FN1 1 GO:0048489 synaptic vesicle transport 1/308 42/18722 0.502156153742597 0.608955798244744 SNCA 1 GO:0051602 response to electrical stimulus 1/308 42/18722 0.502156153742597 0.608955798244744 SOD2 1 GO:0055090 acylglycerol homeostasis 1/308 42/18722 0.502156153742597 0.608955798244744 APOE 1 GO:0060999 positive regulation of dendritic spine development 1/308 42/18722 0.502156153742597 0.608955798244744 APOE 1 GO:0070328 triglyceride homeostasis 1/308 42/18722 0.502156153742597 0.608955798244744 APOE 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/308 42/18722 0.502156153742597 0.608955798244744 KLF4 1 GO:1900274 regulation of phospholipase C activity 1/308 42/18722 0.502156153742597 0.608955798244744 EGFR 1 GO:2000404 regulation of T cell migration 1/308 42/18722 0.502156153742597 0.608955798244744 CXCL10 1 GO:2001222 regulation of neuron migration 1/308 42/18722 0.502156153742597 0.608955798244744 PHACTR1 1 GO:0015850 organic hydroxy compound transport 5/308 284/18722 0.502204410152545 0.608955798244744 NFKBIA/SNCA/LY6E/APOE/APOC1 5 GO:0072659 protein localization to plasma membrane 5/308 284/18722 0.502204410152545 0.608955798244744 VAMP2/GBP1/RAB8A/EGFR/MYADM 5 GO:1902749 regulation of cell cycle G2/M phase transition 2/308 102/18722 0.50223322831956 0.608955798244744 SYF2/NPM1 2 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 2/308 103/18722 0.507417953759184 0.614140478887416 SOCS3/HES1 2 GO:0006364 rRNA processing 4/308 225/18722 0.508251709659629 0.614140478887416 RPS28/SBDS/RPS27/RPS15 4 GO:0008037 cell recognition 4/308 225/18722 0.508251709659629 0.614140478887416 VDAC2/CXCR4/ALDOA/CD9 4 GO:0016485 protein processing 4/308 225/18722 0.508251709659629 0.614140478887416 SRGN/CASP1/SEC11A/CTSH 4 GO:0006936 muscle contraction 6/308 347/18722 0.508533351233183 0.614140478887416 CXCR4/SRI/DSP/ALDOA/CALM1/TPM3 6 GO:0001504 neurotransmitter uptake 1/308 43/18722 0.510364713948554 0.614140478887416 SNCA 1 GO:0002861 regulation of inflammatory response to antigenic stimulus 1/308 43/18722 0.510364713948554 0.614140478887416 HLA-DRB1 1 GO:0006284 base-excision repair 1/308 43/18722 0.510364713948554 0.614140478887416 HMGB1 1 GO:0009268 response to pH 1/308 43/18722 0.510364713948554 0.614140478887416 SERPINF1 1 GO:0014014 negative regulation of gliogenesis 1/308 43/18722 0.510364713948554 0.614140478887416 HES1 1 GO:0021983 pituitary gland development 1/308 43/18722 0.510364713948554 0.614140478887416 HES1 1 GO:0031952 regulation of protein autophosphorylation 1/308 43/18722 0.510364713948554 0.614140478887416 CALM1 1 GO:0033173 calcineurin-NFAT signaling cascade 1/308 43/18722 0.510364713948554 0.614140478887416 CAMTA1 1 GO:0042181 ketone biosynthetic process 1/308 43/18722 0.510364713948554 0.614140478887416 EGR1 1 GO:0045840 positive regulation of mitotic nuclear division 1/308 43/18722 0.510364713948554 0.614140478887416 IL1B 1 GO:0045981 positive regulation of nucleotide metabolic process 1/308 43/18722 0.510364713948554 0.614140478887416 TMSB4X 1 GO:0046717 acid secretion 1/308 43/18722 0.510364713948554 0.614140478887416 SGK1 1 GO:0061383 trabecula morphogenesis 1/308 43/18722 0.510364713948554 0.614140478887416 FBN2 1 GO:0098927 vesicle-mediated transport between endosomal compartments 1/308 43/18722 0.510364713948554 0.614140478887416 SNX3 1 GO:0120178 steroid hormone biosynthetic process 1/308 43/18722 0.510364713948554 0.614140478887416 EGR1 1 GO:0140353 lipid export from cell 1/308 43/18722 0.510364713948554 0.614140478887416 IL1B 1 GO:1900544 positive regulation of purine nucleotide metabolic process 1/308 43/18722 0.510364713948554 0.614140478887416 TMSB4X 1 GO:1904591 positive regulation of protein import 1/308 43/18722 0.510364713948554 0.614140478887416 HSP90AB1 1 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 1/308 43/18722 0.510364713948554 0.614140478887416 SOD2 1 GO:0007286 spermatid development 3/308 165/18722 0.512116579819335 0.616015534856752 UBE2B/HMGB2/DEFB1 3 GO:0006892 post-Golgi vesicle-mediated transport 2/308 104/18722 0.512567464394279 0.616015534856752 VAMP2/LAPTM5 2 GO:0022600 digestive system process 2/308 104/18722 0.512567464394279 0.616015534856752 TYMP/SGK1 2 GO:1903076 regulation of protein localization to plasma membrane 2/308 104/18722 0.512567464394279 0.616015534856752 GBP1/EGFR 2 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 2/308 105/18722 0.517681512721028 0.620924140707458 RALA/RAC1 2 GO:0005978 glycogen biosynthetic process 1/308 44/18722 0.518438361793933 0.620924140707458 PTGES3 1 GO:0006775 fat-soluble vitamin metabolic process 1/308 44/18722 0.518438361793933 0.620924140707458 CBR1 1 GO:0009250 glucan biosynthetic process 1/308 44/18722 0.518438361793933 0.620924140707458 PTGES3 1 GO:0009262 deoxyribonucleotide metabolic process 1/308 44/18722 0.518438361793933 0.620924140707458 TYMP 1 GO:0032007 negative regulation of TOR signaling 1/308 44/18722 0.518438361793933 0.620924140707458 DDIT4 1 GO:0046006 regulation of activated T cell proliferation 1/308 44/18722 0.518438361793933 0.620924140707458 HMGB1 1 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 1/308 44/18722 0.518438361793933 0.620924140707458 HES1 1 GO:0051150 regulation of smooth muscle cell differentiation 1/308 44/18722 0.518438361793933 0.620924140707458 SOD2 1 GO:0097178 ruffle assembly 1/308 44/18722 0.518438361793933 0.620924140707458 RAC1 1 GO:1903214 regulation of protein targeting to mitochondrion 1/308 44/18722 0.518438361793933 0.620924140707458 BNIP3L 1 GO:0009451 RNA modification 3/308 167/18722 0.520203024499927 0.622842518842224 SSB/LARP7/APOBEC3A 3 GO:0071887 leukocyte apoptotic process 2/308 106/18722 0.522759868827351 0.625707883070433 TSC22D3/ANXA1 2 GO:0002920 regulation of humoral immune response 1/308 45/18722 0.526379307535847 0.628073686863154 IL1B 1 GO:0003254 regulation of membrane depolarization 1/308 45/18722 0.526379307535847 0.628073686863154 IFI6 1 GO:0030835 negative regulation of actin filament depolymerization 1/308 45/18722 0.526379307535847 0.628073686863154 SWAP70 1 GO:0035987 endodermal cell differentiation 1/308 45/18722 0.526379307535847 0.628073686863154 FN1 1 GO:0044088 regulation of vacuole organization 1/308 45/18722 0.526379307535847 0.628073686863154 NUPR1 1 GO:0060119 inner ear receptor cell development 1/308 45/18722 0.526379307535847 0.628073686863154 HES1 1 GO:0060421 positive regulation of heart growth 1/308 45/18722 0.526379307535847 0.628073686863154 BASP1 1 GO:0098534 centriole assembly 1/308 45/18722 0.526379307535847 0.628073686863154 NPM1 1 GO:1901985 positive regulation of protein acetylation 1/308 45/18722 0.526379307535847 0.628073686863154 IL1B 1 GO:2000273 positive regulation of signaling receptor activity 1/308 45/18722 0.526379307535847 0.628073686863154 NCF1 1 GO:0000018 regulation of DNA recombination 2/308 107/18722 0.527802319884566 0.629182497324196 UBE2B/PPP4C 2 GO:0007229 integrin-mediated signaling pathway 2/308 107/18722 0.527802319884566 0.629182497324196 ISG15/FN1 2 GO:0010927 cellular component assembly involved in morphogenesis 2/308 107/18722 0.527802319884566 0.629182497324196 KRT8/CD9 2 GO:0006937 regulation of muscle contraction 3/308 169/18722 0.528216607806382 0.62928391762038 SRI/DSP/CALM1 3 GO:0018394 peptidyl-lysine acetylation 3/308 169/18722 0.528216607806382 0.62928391762038 SNCA/IL1B/SET 3 GO:0006958 complement activation, classical pathway 2/308 108/18722 0.532808669650934 0.634422901511261 C1QC/C1QA 2 GO:0010830 regulation of myotube differentiation 1/308 46/18722 0.534189725337366 0.634422901511261 BHLHE41 1 GO:0035094 response to nicotine 1/308 46/18722 0.534189725337366 0.634422901511261 B2M 1 GO:0042398 cellular modified amino acid biosynthetic process 1/308 46/18722 0.534189725337366 0.634422901511261 PLSCR1 1 GO:0043300 regulation of leukocyte degranulation 1/308 46/18722 0.534189725337366 0.634422901511261 HLA-F 1 GO:0043462 regulation of ATPase activity 1/308 46/18722 0.534189725337366 0.634422901511261 GABARAPL2 1 GO:0043616 keratinocyte proliferation 1/308 46/18722 0.534189725337366 0.634422901511261 ZFP36 1 GO:0044818 mitotic G2/M transition checkpoint 1/308 46/18722 0.534189725337366 0.634422901511261 SYF2 1 GO:0072599 establishment of protein localization to endoplasmic reticulum 1/308 46/18722 0.534189725337366 0.634422901511261 HERPUD1 1 GO:2000107 negative regulation of leukocyte apoptotic process 1/308 46/18722 0.534189725337366 0.634422901511261 TSC22D3 1 GO:0034329 cell junction assembly 7/308 420/18722 0.539403905572893 0.639572619631929 SNCA/IL1B/SDCBP/RAC1/FN1/CD9/VMP1 7 GO:0007219 Notch signaling pathway 3/308 172/18722 0.540096788784996 0.639572619631929 NFKBIA/CFD/HES1 3 GO:0048515 spermatid differentiation 3/308 172/18722 0.540096788784996 0.639572619631929 UBE2B/HMGB2/DEFB1 3 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 1/308 47/18722 0.54187175385504 0.639572619631929 SOD2 1 GO:0010761 fibroblast migration 1/308 47/18722 0.54187175385504 0.639572619631929 RAC1 1 GO:0016073 snRNA metabolic process 1/308 47/18722 0.54187175385504 0.639572619631929 LARP7 1 GO:0016574 histone ubiquitination 1/308 47/18722 0.54187175385504 0.639572619631929 UBE2B 1 GO:0031641 regulation of myelination 1/308 47/18722 0.54187175385504 0.639572619631929 TYMP 1 GO:0032369 negative regulation of lipid transport 1/308 47/18722 0.54187175385504 0.639572619631929 APOC1 1 GO:0035315 hair cell differentiation 1/308 47/18722 0.54187175385504 0.639572619631929 HES1 1 GO:0043114 regulation of vascular permeability 1/308 47/18722 0.54187175385504 0.639572619631929 APOE 1 GO:0045332 phospholipid translocation 1/308 47/18722 0.54187175385504 0.639572619631929 PLSCR1 1 GO:0045747 positive regulation of Notch signaling pathway 1/308 47/18722 0.54187175385504 0.639572619631929 HES1 1 GO:0045911 positive regulation of DNA recombination 1/308 47/18722 0.54187175385504 0.639572619631929 UBE2B 1 GO:0048512 circadian behavior 1/308 47/18722 0.54187175385504 0.639572619631929 EGR1 1 GO:0050798 activated T cell proliferation 1/308 47/18722 0.54187175385504 0.639572619631929 HMGB1 1 GO:0051489 regulation of filopodium assembly 1/308 47/18722 0.54187175385504 0.639572619631929 RALA 1 GO:0090279 regulation of calcium ion import 1/308 47/18722 0.54187175385504 0.639572619631929 CCL3 1 GO:0101023 vascular endothelial cell proliferation 1/308 47/18722 0.54187175385504 0.639572619631929 HMGB1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/308 47/18722 0.54187175385504 0.639572619631929 HMGB1 1 GO:0003014 renal system process 2/308 110/18722 0.542712360381232 0.639774700504918 COMT/SGK1 2 GO:0014812 muscle cell migration 2/308 110/18722 0.542712360381232 0.639774700504918 TRIB1/ANXA1 2 GO:0061387 regulation of extent of cell growth 2/308 110/18722 0.542712360381232 0.639774700504918 APOE/FN1 2 GO:1904659 glucose transmembrane transport 2/308 110/18722 0.542712360381232 0.639774700504918 IL1B/HK2 2 GO:0010469 regulation of signaling receptor activity 3/308 173/18722 0.54401870160859 0.641116984047361 PHLDA2/LY6E/NCF1 3 GO:0016072 rRNA metabolic process 4/308 236/18722 0.545827489640858 0.642852277540666 RPS28/SBDS/RPS27/RPS15 4 GO:0048738 cardiac muscle tissue development 4/308 236/18722 0.545827489640858 0.642852277540666 LY6E/CACYBP/DSP/HNRNPU 4 GO:0001938 positive regulation of endothelial cell proliferation 2/308 111/18722 0.547609387489485 0.644752290844564 HMGB2/HMGB1 2 GO:0048639 positive regulation of developmental growth 3/308 174/18722 0.547921242757474 0.644906760924468 CXCR4/BASP1/FN1 3 GO:0002673 regulation of acute inflammatory response 1/308 48/18722 0.549427496816896 0.644906760924468 IL1B 1 GO:0010569 regulation of double-strand break repair via homologous recombination 1/308 48/18722 0.549427496816896 0.644906760924468 PPP4C 1 GO:0033628 regulation of cell adhesion mediated by integrin 1/308 48/18722 0.549427496816896 0.644906760924468 SWAP70 1 GO:0042149 cellular response to glucose starvation 1/308 48/18722 0.549427496816896 0.644906760924468 HNRNPA1 1 GO:0044458 motile cilium assembly 1/308 48/18722 0.549427496816896 0.644906760924468 UBE2B 1 GO:0090311 regulation of protein deacetylation 1/308 48/18722 0.549427496816896 0.644906760924468 BEX4 1 GO:0097720 calcineurin-mediated signaling 1/308 48/18722 0.549427496816896 0.644906760924468 CAMTA1 1 GO:0120009 intermembrane lipid transfer 1/308 48/18722 0.549427496816896 0.644906760924468 APOE 1 GO:1902003 regulation of amyloid-beta formation 1/308 48/18722 0.549427496816896 0.644906760924468 APOE 1 GO:0003341 cilium movement 3/308 175/18722 0.551804243407943 0.647299055706833 UBE2B/DNAJA1/DEFB1 3 GO:0048771 tissue remodeling 3/308 175/18722 0.551804243407943 0.647299055706833 TNFAIP3/EGFR/RAC1 3 GO:0001676 long-chain fatty acid metabolic process 2/308 112/18722 0.55246968468178 0.64744400028059 PTGES3/CBR1 2 GO:0009141 nucleoside triphosphate metabolic process 2/308 112/18722 0.55246968468178 0.64744400028059 TMSB4X/ALDOA 2 GO:0043406 positive regulation of MAP kinase activity 2/308 112/18722 0.55246968468178 0.64744400028059 IL1B/EGFR 2 GO:0031589 cell-substrate adhesion 6/308 363/18722 0.552605224408989 0.64744400028059 FBLN1/GBP1/RAC1/MYADM/FN1/LGALS1 6 GO:0032259 methylation 6/308 364/18722 0.555301285414246 0.64924429618437 FOS/PRMT9/COMT/PCMT1/LARP7/BTG1 6 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 1/308 49/18722 0.556859023591041 0.64924429618437 SWAP70 1 GO:0002208 somatic diversification of immunoglobulins involved in immune response 1/308 49/18722 0.556859023591041 0.64924429618437 SWAP70 1 GO:0006778 porphyrin-containing compound metabolic process 1/308 49/18722 0.556859023591041 0.64924429618437 BLVRA 1 GO:0007622 rhythmic behavior 1/308 49/18722 0.556859023591041 0.64924429618437 EGR1 1 GO:0008038 neuron recognition 1/308 49/18722 0.556859023591041 0.64924429618437 CXCR4 1 GO:0009066 aspartate family amino acid metabolic process 1/308 49/18722 0.556859023591041 0.64924429618437 SMS 1 GO:0009395 phospholipid catabolic process 1/308 49/18722 0.556859023591041 0.64924429618437 APOC1 1 GO:0010823 negative regulation of mitochondrion organization 1/308 49/18722 0.556859023591041 0.64924429618437 HSPA1A 1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1/308 49/18722 0.556859023591041 0.64924429618437 SDCBP 1 GO:0032692 negative regulation of interleukin-1 production 1/308 49/18722 0.556859023591041 0.64924429618437 TNFAIP3 1 GO:0034332 adherens junction organization 1/308 49/18722 0.556859023591041 0.64924429618437 DSP 1 GO:0045190 isotype switching 1/308 49/18722 0.556859023591041 0.64924429618437 SWAP70 1 GO:0060986 endocrine hormone secretion 1/308 49/18722 0.556859023591041 0.64924429618437 IL1B 1 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 1/308 49/18722 0.556859023591041 0.64924429618437 JUN 1 GO:1904894 positive regulation of receptor signaling pathway via STAT 1/308 49/18722 0.556859023591041 0.64924429618437 HES1 1 GO:0051302 regulation of cell division 3/308 177/18722 0.559510980248174 0.652137340697796 IL1B/CALM1/TXNIP 3 GO:0008645 hexose transmembrane transport 2/308 114/18722 0.562079621739569 0.654532559826492 IL1B/HK2 2 GO:0021987 cerebral cortex development 2/308 114/18722 0.562079621739569 0.654532559826492 PHACTR1/BCL2A1 2 GO:1904892 regulation of receptor signaling pathway via STAT 2/308 114/18722 0.562079621739569 0.654532559826492 SOCS3/HES1 2 GO:0060047 heart contraction 4/308 241/18722 0.562411971400942 0.654572284532734 CXCR4/SRI/DSP/CALM1 4 GO:0035725 sodium ion transmembrane transport 3/308 178/18722 0.563334410831428 0.654572284532734 YWHAH/GLRX/FXYD3 3 GO:0006220 pyrimidine nucleotide metabolic process 1/308 50/18722 0.564168369745058 0.654572284532734 TYMP 1 GO:0007140 male meiotic nuclear division 1/308 50/18722 0.564168369745058 0.654572284532734 UBB 1 GO:0010665 regulation of cardiac muscle cell apoptotic process 1/308 50/18722 0.564168369745058 0.654572284532734 NUPR1 1 GO:0015872 dopamine transport 1/308 50/18722 0.564168369745058 0.654572284532734 SNCA 1 GO:0030490 maturation of SSU-rRNA 1/308 50/18722 0.564168369745058 0.654572284532734 RPS28 1 GO:0038093 Fc receptor signaling pathway 1/308 50/18722 0.564168369745058 0.654572284532734 FCGR1B 1 GO:0051646 mitochondrion localization 1/308 50/18722 0.564168369745058 0.654572284532734 UBB 1 GO:0060425 lung morphogenesis 1/308 50/18722 0.564168369745058 0.654572284532734 CTSH 1 GO:0070231 T cell apoptotic process 1/308 50/18722 0.564168369745058 0.654572284532734 TSC22D3 1 GO:0090102 cochlea development 1/308 50/18722 0.564168369745058 0.654572284532734 HES1 1 GO:0006310 DNA recombination 5/308 305/18722 0.56552189911902 0.65594363480947 UBE2B/HMGB2/SWAP70/PPP4C/HMGB1 5 GO:0000077 DNA damage checkpoint signaling 2/308 115/18722 0.566829062004979 0.657260389458609 SYF2/RPS27L 2 GO:0043543 protein acylation 4/308 243/18722 0.568953314037221 0.659523505022528 SNCA/NUPR1/IL1B/SET 4 GO:0015698 inorganic anion transport 3/308 180/18722 0.570920678930788 0.660321144271631 CEBPB/VDAC2/FXYD3 3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/308 51/18722 0.571357537596307 0.660321144271631 SNCA 1 GO:0009948 anterior/posterior axis specification 1/308 51/18722 0.571357537596307 0.660321144271631 BASP1 1 GO:0010656 negative regulation of muscle cell apoptotic process 1/308 51/18722 0.571357537596307 0.660321144271631 NUPR1 1 GO:0050982 detection of mechanical stimulus 1/308 51/18722 0.571357537596307 0.660321144271631 CXCR4 1 GO:0060632 regulation of microtubule-based movement 1/308 51/18722 0.571357537596307 0.660321144271631 DEFB1 1 GO:1903307 positive regulation of regulated secretory pathway 1/308 51/18722 0.571357537596307 0.660321144271631 HLA-F 1 GO:0006720 isoprenoid metabolic process 2/308 116/18722 0.571541372324046 0.660321144271631 SCPEP1/EGFR 2 GO:0015749 monosaccharide transmembrane transport 2/308 116/18722 0.571541372324046 0.660321144271631 IL1B/HK2 2 GO:0018107 peptidyl-threonine phosphorylation 2/308 116/18722 0.571541372324046 0.660321144271631 DDIT4/CALM1 2 GO:0031123 RNA 3'-end processing 2/308 116/18722 0.571541372324046 0.660321144271631 SSB/LARP7 2 GO:0006479 protein methylation 3/308 181/18722 0.574683247738109 0.663349654620408 PRMT9/PCMT1/BTG1 3 GO:0008213 protein alkylation 3/308 181/18722 0.574683247738109 0.663349654620408 PRMT9/PCMT1/BTG1 3 GO:0099504 synaptic vesicle cycle 3/308 181/18722 0.574683247738109 0.663349654620408 SNCA/VAMP2/CALM1 3 GO:0006814 sodium ion transport 4/308 245/18722 0.57544039039396 0.664023124804138 YWHAH/GLRX/SGK1/FXYD3 4 GO:1903828 negative regulation of cellular protein localization 2/308 117/18722 0.576216485235409 0.664718051615863 GBP1/DNAJA1 2 GO:0051260 protein homooligomerization 3/308 182/18722 0.57842527049469 0.66506229867305 B2M/SOD2/ALDOA 3 GO:0061138 morphogenesis of a branching epithelium 3/308 182/18722 0.57842527049469 0.66506229867305 GRB2/SOCS3/CTSH 3 GO:0007129 homologous chromosome pairing at meiosis 1/308 52/18722 0.578428496753307 0.66506229867305 UBE2B 1 GO:0010662 regulation of striated muscle cell apoptotic process 1/308 52/18722 0.578428496753307 0.66506229867305 NUPR1 1 GO:0030514 negative regulation of BMP signaling pathway 1/308 52/18722 0.578428496753307 0.66506229867305 FBN1 1 GO:0031103 axon regeneration 1/308 52/18722 0.578428496753307 0.66506229867305 KLF4 1 GO:0034204 lipid translocation 1/308 52/18722 0.578428496753307 0.66506229867305 PLSCR1 1 GO:0048260 positive regulation of receptor-mediated endocytosis 1/308 52/18722 0.578428496753307 0.66506229867305 B2M 1 GO:0051496 positive regulation of stress fiber assembly 1/308 52/18722 0.578428496753307 0.66506229867305 RAC1 1 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 1/308 52/18722 0.578428496753307 0.66506229867305 RAC1 1 GO:2000378 negative regulation of reactive oxygen species metabolic process 1/308 52/18722 0.578428496753307 0.66506229867305 HK2 1 GO:0022612 gland morphogenesis 2/308 118/18722 0.58085434550022 0.667249447970956 CEBPB/TNFAIP3 2 GO:0030203 glycosaminoglycan metabolic process 2/308 118/18722 0.58085434550022 0.667249447970956 IL1B/ITIH5 2 GO:0034219 carbohydrate transmembrane transport 2/308 118/18722 0.58085434550022 0.667249447970956 IL1B/HK2 2 GO:0150063 visual system development 6/308 375/18722 0.58445037044154 0.670519508646643 KLF4/FBN2/SERPINF1/HMGB1/FBN1/C1QA 6 GO:0021537 telencephalon development 4/308 248/18722 0.585067332000106 0.670519508646643 CXCR4/PHACTR1/BCL2A1/HES1 4 GO:0001541 ovarian follicle development 1/308 53/18722 0.585383184648324 0.670519508646643 CEBPB 1 GO:0031279 regulation of cyclase activity 1/308 53/18722 0.585383184648324 0.670519508646643 CALM1 1 GO:0043113 receptor clustering 1/308 53/18722 0.585383184648324 0.670519508646643 APOE 1 GO:0097479 synaptic vesicle localization 1/308 53/18722 0.585383184648324 0.670519508646643 SNCA 1 GO:1903202 negative regulation of oxidative stress-induced cell death 1/308 53/18722 0.585383184648324 0.670519508646643 SOD2 1 GO:1990090 cellular response to nerve growth factor stimulus 1/308 53/18722 0.585383184648324 0.670519508646643 ARPC3 1 GO:2000772 regulation of cellular senescence 1/308 53/18722 0.585383184648324 0.670519508646643 B2M 1 GO:0010906 regulation of glucose metabolic process 2/308 119/18722 0.585454909720768 0.670519508646643 PHLDA2/HMGB1 2 GO:0055001 muscle cell development 3/308 184/18722 0.585847205096186 0.670767854172722 KRT8/HNRNPU/HES1 3 GO:0018205 peptidyl-lysine modification 6/308 376/18722 0.587052128809789 0.671946194143659 SNCA/IL1B/IFIH1/EGR1/SUMO2/SET 6 GO:0045926 negative regulation of growth 4/308 249/18722 0.588248252447741 0.673113759086415 HSPA1A/BST2/HSPA1B/BTG1 4 GO:0006304 DNA modification 2/308 120/18722 0.590018145968274 0.674633631554067 FOS/APOBEC3A 2 GO:0046394 carboxylic acid biosynthetic process 5/308 314/18722 0.591382795534968 0.674633631554067 IL1B/PTGES3/CBR1/ANXA1/APOC1 5 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/308 54/18722 0.592223507061326 0.674633631554067 HLA-F 1 GO:0006968 cellular defense response 1/308 54/18722 0.592223507061326 0.674633631554067 NCF1 1 GO:0010659 cardiac muscle cell apoptotic process 1/308 54/18722 0.592223507061326 0.674633631554067 NUPR1 1 GO:0030520 intracellular estrogen receptor signaling pathway 1/308 54/18722 0.592223507061326 0.674633631554067 DDX5 1 GO:0030834 regulation of actin filament depolymerization 1/308 54/18722 0.592223507061326 0.674633631554067 SWAP70 1 GO:0043647 inositol phosphate metabolic process 1/308 54/18722 0.592223507061326 0.674633631554067 SNCA 1 GO:0070228 regulation of lymphocyte apoptotic process 1/308 54/18722 0.592223507061326 0.674633631554067 TSC22D3 1 GO:0070839 metal ion export 1/308 54/18722 0.592223507061326 0.674633631554067 CALM1 1 GO:0072698 protein localization to microtubule cytoskeleton 1/308 54/18722 0.592223507061326 0.674633631554067 HNRNPU 1 GO:0086002 cardiac muscle cell action potential involved in contraction 1/308 54/18722 0.592223507061326 0.674633631554067 DSP 1 GO:1902743 regulation of lamellipodium organization 1/308 54/18722 0.592223507061326 0.674633631554067 RAC1 1 GO:2000179 positive regulation of neural precursor cell proliferation 1/308 54/18722 0.592223507061326 0.674633631554067 NAP1L1 1 GO:2000300 regulation of synaptic vesicle exocytosis 1/308 54/18722 0.592223507061326 0.674633631554067 CALM1 1 GO:0008217 regulation of blood pressure 3/308 186/18722 0.593185593898687 0.675528306665082 SCPEP1/SOD2/SGK1 3 GO:0002455 humoral immune response mediated by circulating immunoglobulin 2/308 121/18722 0.594544033419667 0.67649739493358 C1QC/C1QA 2 GO:0043500 muscle adaptation 2/308 121/18722 0.594544033419667 0.67649739493358 KLF4/IL1B 2 GO:0003015 heart process 4/308 251/18722 0.594567420082874 0.67649739493358 CXCR4/SRI/DSP/CALM1 4 GO:0016053 organic acid biosynthetic process 5/308 316/18722 0.597014374749659 0.678877440412833 IL1B/PTGES3/CBR1/ANXA1/APOC1 5 GO:0043414 macromolecule methylation 5/308 316/18722 0.597014374749659 0.678877440412833 FOS/PRMT9/PCMT1/LARP7/BTG1 5 GO:0090257 regulation of muscle system process 4/308 252/18722 0.59770548372978 0.679461214480805 KLF4/SRI/DSP/CALM1 4 GO:0001755 neural crest cell migration 1/308 55/18722 0.598951338635415 0.679463195134479 FN1 1 GO:0002067 glandular epithelial cell differentiation 1/308 55/18722 0.598951338635415 0.679463195134479 HES1 1 GO:0006360 transcription by RNA polymerase I 1/308 55/18722 0.598951338635415 0.679463195134479 NCL 1 GO:0048016 inositol phosphate-mediated signaling 1/308 55/18722 0.598951338635415 0.679463195134479 CAMTA1 1 GO:0051898 negative regulation of protein kinase B signaling 1/308 55/18722 0.598951338635415 0.679463195134479 KLF4 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/308 55/18722 0.598951338635415 0.679463195134479 NCF1 1 GO:1902991 regulation of amyloid precursor protein catabolic process 1/308 55/18722 0.598951338635415 0.679463195134479 APOE 1 GO:0048880 sensory system development 6/308 381/18722 0.599934456940194 0.680376573385453 KLF4/FBN2/SERPINF1/HMGB1/FBN1/C1QA 6 GO:0048839 inner ear development 3/308 188/18722 0.60043963667871 0.680747547752879 ANP32B/MAFB/HES1 3 GO:0031570 DNA integrity checkpoint signaling 2/308 123/18722 0.603483732052227 0.683521837879161 SYF2/RPS27L 2 GO:0009165 nucleotide biosynthetic process 4/308 254/18722 0.603938134619687 0.683521837879161 SNCA/TMSB4X/MPC2/ALDOA 4 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/308 56/18722 0.605568523383918 0.683521837879161 ZFP36 1 GO:0002090 regulation of receptor internalization 1/308 56/18722 0.605568523383918 0.683521837879161 SDCBP 1 GO:0010518 positive regulation of phospholipase activity 1/308 56/18722 0.605568523383918 0.683521837879161 EGFR 1 GO:0010658 striated muscle cell apoptotic process 1/308 56/18722 0.605568523383918 0.683521837879161 NUPR1 1 GO:0015800 acidic amino acid transport 1/308 56/18722 0.605568523383918 0.683521837879161 SNCA 1 GO:0022029 telencephalon cell migration 1/308 56/18722 0.605568523383918 0.683521837879161 CXCR4 1 GO:0031529 ruffle organization 1/308 56/18722 0.605568523383918 0.683521837879161 RAC1 1 GO:0046622 positive regulation of organ growth 1/308 56/18722 0.605568523383918 0.683521837879161 BASP1 1 GO:0050433 regulation of catecholamine secretion 1/308 56/18722 0.605568523383918 0.683521837879161 SNCA 1 GO:0055078 sodium ion homeostasis 1/308 56/18722 0.605568523383918 0.683521837879161 COMT 1 GO:0070534 protein K63-linked ubiquitination 1/308 56/18722 0.605568523383918 0.683521837879161 UBE2B 1 GO:0090175 regulation of establishment of planar polarity 1/308 56/18722 0.605568523383918 0.683521837879161 RAC1 1 GO:1990089 response to nerve growth factor 1/308 56/18722 0.605568523383918 0.683521837879161 ARPC3 1 GO:0043547 positive regulation of GTPase activity 4/308 255/18722 0.607032556418265 0.684972096572322 CCL3/CCL3L3/CCL4/RGS1 4 GO:0009566 fertilization 3/308 190/18722 0.607608618882153 0.685419814100464 VDAC2/ALDOA/CD9 3 GO:0016042 lipid catabolic process 5/308 320/18722 0.608147030099784 0.68582480710073 YWHAH/IL1B/APOE/ASAH1/APOC1 5 GO:1901293 nucleoside phosphate biosynthetic process 4/308 256/18722 0.610112270403472 0.68763538023363 SNCA/TMSB4X/MPC2/ALDOA 4 GO:1903522 regulation of blood circulation 4/308 256/18722 0.610112270403472 0.68763538023363 SRI/EGFR/DSP/CALM1 4 GO:0006695 cholesterol biosynthetic process 1/308 57/18722 0.612076875189219 0.688245717463007 APOE 1 GO:0016447 somatic recombination of immunoglobulin gene segments 1/308 57/18722 0.612076875189219 0.688245717463007 SWAP70 1 GO:0030219 megakaryocyte differentiation 1/308 57/18722 0.612076875189219 0.688245717463007 HMGB2 1 GO:0034205 amyloid-beta formation 1/308 57/18722 0.612076875189219 0.688245717463007 APOE 1 GO:0061756 leukocyte adhesion to vascular endothelial cell 1/308 57/18722 0.612076875189219 0.688245717463007 KLF4 1 GO:1902653 secondary alcohol biosynthetic process 1/308 57/18722 0.612076875189219 0.688245717463007 APOE 1 GO:0018210 peptidyl-threonine modification 2/308 125/18722 0.61227404789215 0.688245717463007 DDIT4/CALM1 2 GO:0055007 cardiac muscle cell differentiation 2/308 125/18722 0.61227404789215 0.688245717463007 CACYBP/HNRNPU 2 GO:1904375 regulation of protein localization to cell periphery 2/308 125/18722 0.61227404789215 0.688245717463007 GBP1/EGFR 2 GO:0001954 positive regulation of cell-matrix adhesion 1/308 58/18722 0.618478178293517 0.692978334002378 RAC1 1 GO:0006826 iron ion transport 1/308 58/18722 0.618478178293517 0.692978334002378 B2M 1 GO:0007131 reciprocal meiotic recombination 1/308 58/18722 0.618478178293517 0.692978334002378 UBE2B 1 GO:0010574 regulation of vascular endothelial growth factor production 1/308 58/18722 0.618478178293517 0.692978334002378 IL1B 1 GO:0018208 peptidyl-proline modification 1/308 58/18722 0.618478178293517 0.692978334002378 P4HA1 1 GO:0032387 negative regulation of intracellular transport 1/308 58/18722 0.618478178293517 0.692978334002378 SNX3 1 GO:0035904 aorta development 1/308 58/18722 0.618478178293517 0.692978334002378 HES1 1 GO:0043506 regulation of JUN kinase activity 1/308 58/18722 0.618478178293517 0.692978334002378 DNAJA1 1 GO:0044380 protein localization to cytoskeleton 1/308 58/18722 0.618478178293517 0.692978334002378 HNRNPU 1 GO:0097035 regulation of membrane lipid distribution 1/308 58/18722 0.618478178293517 0.692978334002378 PLSCR1 1 GO:0140527 reciprocal homologous recombination 1/308 58/18722 0.618478178293517 0.692978334002378 UBE2B 1 GO:0030048 actin filament-based movement 2/308 127/18722 0.620915179096966 0.695505048253062 SRI/DSP 2 GO:0002820 negative regulation of adaptive immune response 1/308 59/18722 0.624774187781601 0.696728305311326 HLA-F 1 GO:0006406 mRNA export from nucleus 1/308 59/18722 0.624774187781601 0.696728305311326 SRSF3 1 GO:0021885 forebrain cell migration 1/308 59/18722 0.624774187781601 0.696728305311326 CXCR4 1 GO:0030042 actin filament depolymerization 1/308 59/18722 0.624774187781601 0.696728305311326 SWAP70 1 GO:0033013 tetrapyrrole metabolic process 1/308 59/18722 0.624774187781601 0.696728305311326 BLVRA 1 GO:0046324 regulation of glucose import 1/308 59/18722 0.624774187781601 0.696728305311326 HK2 1 GO:0048010 vascular endothelial growth factor receptor signaling pathway 1/308 59/18722 0.624774187781601 0.696728305311326 IL1B 1 GO:0048278 vesicle docking 1/308 59/18722 0.624774187781601 0.696728305311326 RAB8A 1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 1/308 59/18722 0.624774187781601 0.696728305311326 SOCS3 1 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 1/308 59/18722 0.624774187781601 0.696728305311326 SRSF3 1 GO:0071806 protein transmembrane transport 1/308 59/18722 0.624774187781601 0.696728305311326 MCL1 1 GO:2000351 regulation of endothelial cell apoptotic process 1/308 59/18722 0.624774187781601 0.696728305311326 TNFAIP3 1 GO:0030705 cytoskeleton-dependent intracellular transport 3/308 195/18722 0.625154984151817 0.696728305311326 HNRNPU/TUBA1B/UBB 3 GO:0006639 acylglycerol metabolic process 2/308 128/18722 0.625179902500739 0.696728305311326 APOE/APOC1 2 GO:0033865 nucleoside bisphosphate metabolic process 2/308 128/18722 0.625179902500739 0.696728305311326 SNCA/MPC2 2 GO:0033875 ribonucleoside bisphosphate metabolic process 2/308 128/18722 0.625179902500739 0.696728305311326 SNCA/MPC2 2 GO:0034032 purine nucleoside bisphosphate metabolic process 2/308 128/18722 0.625179902500739 0.696728305311326 SNCA/MPC2 2 GO:0090305 nucleic acid phosphodiester bond hydrolysis 4/308 261/18722 0.625287683893057 0.696728305311326 PLSCR1/ZFP36/RNASET2/DNASE2 4 GO:0001763 morphogenesis of a branching structure 3/308 196/18722 0.62859928075822 0.700010209827753 GRB2/SOCS3/CTSH 3 GO:0045664 regulation of neuron differentiation 3/308 196/18722 0.62859928075822 0.700010209827753 B2M/YWHAH/HES1 3 GO:0006022 aminoglycan metabolic process 2/308 129/18722 0.629407469553463 0.700298241007825 IL1B/ITIH5 2 GO:0007127 meiosis I 2/308 129/18722 0.629407469553463 0.700298241007825 UBE2B/UBB 2 GO:0007498 mesoderm development 2/308 129/18722 0.629407469553463 0.700298241007825 KLF4/MEST 2 GO:0006081 cellular aldehyde metabolic process 1/308 60/18722 0.630966630055794 0.700402272561934 TKT 1 GO:0006289 nucleotide-excision repair 1/308 60/18722 0.630966630055794 0.700402272561934 HMGB1 1 GO:0006893 Golgi to plasma membrane transport 1/308 60/18722 0.630966630055794 0.700402272561934 VAMP2 1 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 1/308 60/18722 0.630966630055794 0.700402272561934 SYF2 1 GO:0031102 neuron projection regeneration 1/308 60/18722 0.630966630055794 0.700402272561934 KLF4 1 GO:0031638 zymogen activation 1/308 60/18722 0.630966630055794 0.700402272561934 CTSH 1 GO:0035825 homologous recombination 1/308 60/18722 0.630966630055794 0.700402272561934 UBE2B 1 GO:0042306 regulation of protein import into nucleus 1/308 60/18722 0.630966630055794 0.700402272561934 HSP90AB1 1 GO:0030534 adult behavior 2/308 130/18722 0.633597944426154 0.703118996093233 SNCA/NR4A2 2 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 4/308 264/18722 0.634212047474359 0.703596244194566 NCF1/EGFR/SOCS3/HES1 4 GO:0034470 ncRNA processing 6/308 395/18722 0.634829429905719 0.704076852488995 RPS28/SBDS/SSB/LARP7/RPS27/RPS15 6 GO:0030199 collagen fibril organization 1/308 61/18722 0.637057203303185 0.705728683925841 P4HA1 1 GO:0043954 cellular component maintenance 1/308 61/18722 0.637057203303185 0.705728683925841 APOE 1 GO:0060998 regulation of dendritic spine development 1/308 61/18722 0.637057203303185 0.705728683925841 APOE 1 GO:0090342 regulation of cell aging 1/308 61/18722 0.637057203303185 0.705728683925841 B2M 1 GO:0006612 protein targeting to membrane 2/308 131/18722 0.637751399216188 0.705974922833214 NCF1/SDCBP 2 GO:0019827 stem cell population maintenance 2/308 131/18722 0.637751399216188 0.705974922833214 KLF4/HES1 2 GO:0003002 regionalization 5/308 331/18722 0.637833477234089 0.705974922833214 BASP1/BHLHE41/MAFB/HES1/C1QA 5 GO:0007569 cell aging 2/308 132/18722 0.64186791367086 0.709318111774611 B2M/NPM1 2 GO:0045216 cell-cell junction organization 3/308 200/18722 0.642158245784138 0.709318111774611 IL1B/DSP/CD9 3 GO:0007588 excretion 1/308 62/18722 0.643047577955274 0.709318111774611 COMT 1 GO:0010573 vascular endothelial growth factor production 1/308 62/18722 0.643047577955274 0.709318111774611 IL1B 1 GO:0045576 mast cell activation 1/308 62/18722 0.643047577955274 0.709318111774611 PLSCR1 1 GO:0046847 filopodium assembly 1/308 62/18722 0.643047577955274 0.709318111774611 RALA 1 GO:0060113 inner ear receptor cell differentiation 1/308 62/18722 0.643047577955274 0.709318111774611 HES1 1 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 1/308 62/18722 0.643047577955274 0.709318111774611 SDCBP 1 GO:0060675 ureteric bud morphogenesis 1/308 62/18722 0.643047577955274 0.709318111774611 HES1 1 GO:1902750 negative regulation of cell cycle G2/M phase transition 1/308 62/18722 0.643047577955274 0.709318111774611 SYF2 1 GO:1903078 positive regulation of protein localization to plasma membrane 1/308 62/18722 0.643047577955274 0.709318111774611 EGFR 1 GO:1990778 protein localization to cell periphery 5/308 333/18722 0.643080453939524 0.709318111774611 VAMP2/GBP1/RAB8A/EGFR/MYADM 5 GO:0009952 anterior/posterior pattern specification 3/308 201/18722 0.64549324773217 0.711774065786007 BASP1/BHLHE41/HES1 3 GO:0016239 positive regulation of macroautophagy 1/308 63/18722 0.648939397140149 0.714543581586057 BNIP3L 1 GO:0030239 myofibril assembly 1/308 63/18722 0.648939397140149 0.714543581586057 KRT8 1 GO:0045143 homologous chromosome segregation 1/308 63/18722 0.648939397140149 0.714543581586057 UBE2B 1 GO:0072171 mesonephric tubule morphogenesis 1/308 63/18722 0.648939397140149 0.714543581586057 HES1 1 GO:1904589 regulation of protein import 1/308 63/18722 0.648939397140149 0.714543581586057 HSP90AB1 1 GO:0032147 activation of protein kinase activity 2/308 134/18722 0.649990477202421 0.715288887261041 RPLP1/HMGB1 2 GO:0098727 maintenance of cell number 2/308 134/18722 0.649990477202421 0.715288887261041 KLF4/HES1 2 GO:0061982 meiosis I cell cycle process 2/308 135/18722 0.653996721631246 0.718853860269325 UBE2B/UBB 2 GO:0016126 sterol biosynthetic process 1/308 64/18722 0.654734277127331 0.718853860269325 APOE 1 GO:0017156 calcium-ion regulated exocytosis 1/308 64/18722 0.654734277127331 0.718853860269325 VAMP2 1 GO:0030858 positive regulation of epithelial cell differentiation 1/308 64/18722 0.654734277127331 0.718853860269325 BTG1 1 GO:0046579 positive regulation of Ras protein signal transduction 1/308 64/18722 0.654734277127331 0.718853860269325 RAC1 1 GO:0046854 phosphatidylinositol phosphate biosynthetic process 1/308 64/18722 0.654734277127331 0.718853860269325 SOCS3 1 GO:0046888 negative regulation of hormone secretion 1/308 64/18722 0.654734277127331 0.718853860269325 IL1B 1 GO:0055002 striated muscle cell development 1/308 64/18722 0.654734277127331 0.718853860269325 KRT8 1 GO:1901888 regulation of cell junction assembly 3/308 204/18722 0.655366441930049 0.719341345822158 SNCA/IL1B/RAC1 3 GO:1903305 regulation of regulated secretory pathway 2/308 136/18722 0.657966415922655 0.721987832397334 HLA-F/CALM1 2 GO:0060348 bone development 3/308 205/18722 0.65861350865138 0.722490514655445 SBDS/PTGER4/FBN1 3 GO:0046942 carboxylic acid transport 4/308 273/18722 0.660154793319213 0.722828069592631 SNCA/MPC2/IL1B/ANXA1 4 GO:0033692 cellular polysaccharide biosynthetic process 1/308 65/18722 0.660433807765384 0.722828069592631 PTGES3 1 GO:0046503 glycerolipid catabolic process 1/308 65/18722 0.660433807765384 0.722828069592631 APOC1 1 GO:0046513 ceramide biosynthetic process 1/308 65/18722 0.660433807765384 0.722828069592631 ASAH1 1 GO:0048645 animal organ formation 1/308 65/18722 0.660433807765384 0.722828069592631 HES1 1 GO:0060389 pathway-restricted SMAD protein phosphorylation 1/308 65/18722 0.660433807765384 0.722828069592631 SDCBP 1 GO:0072577 endothelial cell apoptotic process 1/308 65/18722 0.660433807765384 0.722828069592631 TNFAIP3 1 GO:1905330 regulation of morphogenesis of an epithelium 1/308 65/18722 0.660433807765384 0.722828069592631 CXCL10 1 GO:0008016 regulation of heart contraction 3/308 206/18722 0.661838555671525 0.723603790199026 SRI/DSP/CALM1 3 GO:0007586 digestion 2/308 137/18722 0.661899674163221 0.723603790199026 TYMP/SGK1 2 GO:0045471 response to ethanol 2/308 137/18722 0.661899674163221 0.723603790199026 SOD2/S100A8 2 GO:0090090 negative regulation of canonical Wnt signaling pathway 2/308 137/18722 0.661899674163221 0.723603790199026 EGR1/APOE 2 GO:0019229 regulation of vasoconstriction 1/308 66/18722 0.66603955291242 0.726675003077678 EGFR 1 GO:0042446 hormone biosynthetic process 1/308 66/18722 0.66603955291242 0.726675003077678 EGR1 1 GO:0050766 positive regulation of phagocytosis 1/308 66/18722 0.66603955291242 0.726675003077678 IL1B 1 GO:0050922 negative regulation of chemotaxis 1/308 66/18722 0.66603955291242 0.726675003077678 DUSP1 1 GO:0051893 regulation of focal adhesion assembly 1/308 66/18722 0.66603955291242 0.726675003077678 RAC1 1 GO:0090109 regulation of cell-substrate junction assembly 1/308 66/18722 0.66603955291242 0.726675003077678 RAC1 1 GO:2000272 negative regulation of signaling receptor activity 1/308 66/18722 0.66603955291242 0.726675003077678 LY6E 1 GO:0006836 neurotransmitter transport 3/308 208/18722 0.668222567226075 0.728848751642021 SNCA/VAMP2/CALM1 3 GO:1903829 positive regulation of cellular protein localization 4/308 276/18722 0.668521924190458 0.728967289269858 HSP90AB1/EGFR/LARP7/NPM1 4 GO:0016579 protein deubiquitination 2/308 139/18722 0.669657369261865 0.729997183543801 TNFAIP3/OTUD1 2 GO:0006879 cellular iron ion homeostasis 1/308 67/18722 0.671553050859621 0.730189793355043 SRI 1 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/308 67/18722 0.671553050859621 0.730189793355043 ANXA1 1 GO:0009880 embryonic pattern specification 1/308 67/18722 0.671553050859621 0.730189793355043 BASP1 1 GO:0016445 somatic diversification of immunoglobulins 1/308 67/18722 0.671553050859621 0.730189793355043 SWAP70 1 GO:0042490 mechanoreceptor differentiation 1/308 67/18722 0.671553050859621 0.730189793355043 HES1 1 GO:0048814 regulation of dendrite morphogenesis 1/308 67/18722 0.671553050859621 0.730189793355043 YWHAH 1 GO:0050435 amyloid-beta metabolic process 1/308 67/18722 0.671553050859621 0.730189793355043 APOE 1 GO:0061180 mammary gland epithelium development 1/308 67/18722 0.671553050859621 0.730189793355043 CEBPB 1 GO:1902117 positive regulation of organelle assembly 1/308 67/18722 0.671553050859621 0.730189793355043 SDCBP 1 GO:0034394 protein localization to cell surface 1/308 68/18722 0.676975814747867 0.73462348560349 HSP90AB1 1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 1/308 68/18722 0.676975814747867 0.73462348560349 HES1 1 GO:0042987 amyloid precursor protein catabolic process 1/308 68/18722 0.676975814747867 0.73462348560349 APOE 1 GO:0051148 negative regulation of muscle cell differentiation 1/308 68/18722 0.676975814747867 0.73462348560349 BHLHE41 1 GO:0060411 cardiac septum morphogenesis 1/308 68/18722 0.676975814747867 0.73462348560349 HES1 1 GO:0061912 selective autophagy 1/308 68/18722 0.676975814747867 0.73462348560349 MAP1LC3B 1 GO:1901016 regulation of potassium ion transmembrane transporter activity 1/308 68/18722 0.676975814747867 0.73462348560349 VAMP2 1 GO:0016241 regulation of macroautophagy 2/308 141/18722 0.677270838119021 0.734735077789165 BNIP3L/NUPR1 2 GO:0050807 regulation of synapse organization 3/308 211/18722 0.677633385192863 0.734919838749593 SNCA/SRGN/APOE 3 GO:0043087 regulation of GTPase activity 5/308 348/18722 0.680903425024112 0.738256889922627 CCL3/CCL3L3/CCL4/RGS1/IQGAP2 5 GO:0003143 embryonic heart tube morphogenesis 1/308 69/18722 0.682309332977612 0.73831547692426 HES1 1 GO:0019226 transmission of nerve impulse 1/308 69/18722 0.682309332977612 0.73831547692426 TYMP 1 GO:0050805 negative regulation of synaptic transmission 1/308 69/18722 0.682309332977612 0.73831547692426 IL1B 1 GO:0051966 regulation of synaptic transmission, glutamatergic 1/308 69/18722 0.682309332977612 0.73831547692426 EGFR 1 GO:0060193 positive regulation of lipase activity 1/308 69/18722 0.682309332977612 0.73831547692426 EGFR 1 GO:0070192 chromosome organization involved in meiotic cell cycle 1/308 69/18722 0.682309332977612 0.73831547692426 UBE2B 1 GO:1904377 positive regulation of protein localization to cell periphery 1/308 69/18722 0.682309332977612 0.73831547692426 EGFR 1 GO:0043583 ear development 3/308 213/18722 0.683797217118023 0.739716118008546 ANP32B/MAFB/HES1 3 GO:0045123 cellular extravasation 1/308 70/18722 0.687555069612089 0.743570871605945 PTGER4 1 GO:0010324 membrane invagination 2/308 144/18722 0.688423086163431 0.743878309328094 SNX3/RAC1 2 GO:0106106 cold-induced thermogenesis 2/308 144/18722 0.688423086163431 0.743878309328094 CEBPB/CXCR4 2 GO:0120161 regulation of cold-induced thermogenesis 2/308 144/18722 0.688423086163431 0.743878309328094 CEBPB/CXCR4 2 GO:0003281 ventricular septum development 1/308 71/18722 0.692714464773974 0.747448197626195 HES1 1 GO:0071230 cellular response to amino acid stimulus 1/308 71/18722 0.692714464773974 0.747448197626195 CEBPB 1 GO:0072078 nephron tubule morphogenesis 1/308 71/18722 0.692714464773974 0.747448197626195 HES1 1 GO:0150116 regulation of cell-substrate junction organization 1/308 71/18722 0.692714464773974 0.747448197626195 RAC1 1 GO:0048562 embryonic organ morphogenesis 4/308 285/18722 0.692771885338121 0.747448197626195 FBN2/MAFB/FBN1/HES1 4 GO:0006066 alcohol metabolic process 5/308 353/18722 0.692899924767783 0.747448197626195 SNCA/ALDH2/ISYNA1/APOE/ASAH1 5 GO:0007043 cell-cell junction assembly 2/308 146/18722 0.695681057401019 0.74981355580606 IL1B/CD9 2 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/308 146/18722 0.695681057401019 0.74981355580606 PTGER4/CXCL10 2 GO:0048813 dendrite morphogenesis 2/308 146/18722 0.695681057401019 0.74981355580606 YWHAH/PHACTR1 2 GO:0000271 polysaccharide biosynthetic process 1/308 72/18722 0.697788935035601 0.750181973746092 PTGES3 1 GO:0001707 mesoderm formation 1/308 72/18722 0.697788935035601 0.750181973746092 KLF4 1 GO:0001736 establishment of planar polarity 1/308 72/18722 0.697788935035601 0.750181973746092 RAC1 1 GO:0007164 establishment of tissue polarity 1/308 72/18722 0.697788935035601 0.750181973746092 RAC1 1 GO:0030032 lamellipodium assembly 1/308 72/18722 0.697788935035601 0.750181973746092 RAC1 1 GO:0035567 non-canonical Wnt signaling pathway 1/308 72/18722 0.697788935035601 0.750181973746092 RAC1 1 GO:0051057 positive regulation of small GTPase mediated signal transduction 1/308 72/18722 0.697788935035601 0.750181973746092 RAC1 1 GO:0070227 lymphocyte apoptotic process 1/308 72/18722 0.697788935035601 0.750181973746092 TSC22D3 1 GO:1901880 negative regulation of protein depolymerization 1/308 72/18722 0.697788935035601 0.750181973746092 SWAP70 1 GO:0042445 hormone metabolic process 3/308 218/18722 0.698822637442731 0.750870978904879 SCPEP1/COMT/EGR1 3 GO:0050803 regulation of synapse structure or activity 3/308 218/18722 0.698822637442731 0.750870978904879 SNCA/SRGN/APOE 3 GO:0009166 nucleotide catabolic process 1/308 73/18722 0.702779873802842 0.754295561513484 TYMP 1 GO:0035924 cellular response to vascular endothelial growth factor stimulus 1/308 73/18722 0.702779873802842 0.754295561513484 ANXA1 1 GO:0051865 protein autoubiquitination 1/308 73/18722 0.702779873802842 0.754295561513484 UBE2B 1 GO:0044272 sulfur compound biosynthetic process 2/308 148/18722 0.70279905574445 0.754295561513484 SNCA/MPC2 2 GO:0002064 epithelial cell development 3/308 220/18722 0.704679696960745 0.756101734909046 IL1B/CXCR4/MYADM 3 GO:0050808 synapse organization 6/308 426/18722 0.705403595186487 0.756666089898412 SNCA/SRGN/SDCBP/APOE/C1QC/C1QA 6 GO:0003151 outflow tract morphogenesis 1/308 74/18722 0.707688651692741 0.758053716845432 HES1 1 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 1/308 74/18722 0.707688651692741 0.758053716845432 DDX5 1 GO:0046323 glucose import 1/308 74/18722 0.707688651692741 0.758053716845432 HK2 1 GO:0046470 phosphatidylcholine metabolic process 1/308 74/18722 0.707688651692741 0.758053716845432 APOC1 1 GO:0048332 mesoderm morphogenesis 1/308 74/18722 0.707688651692741 0.758053716845432 KLF4 1 GO:0006024 glycosaminoglycan biosynthetic process 1/308 75/18722 0.712516616905023 0.762370844228352 IL1B 1 GO:0006094 gluconeogenesis 1/308 75/18722 0.712516616905023 0.762370844228352 ATF3 1 GO:0008088 axo-dendritic transport 1/308 75/18722 0.712516616905023 0.762370844228352 HNRNPU 1 GO:0061333 renal tubule morphogenesis 1/308 75/18722 0.712516616905023 0.762370844228352 HES1 1 GO:0030902 hindbrain development 2/308 151/18722 0.713216624302346 0.76247962939258 MAFB/HES1 2 GO:0048592 eye morphogenesis 2/308 151/18722 0.713216624302346 0.76247962939258 FBN2/FBN1 2 GO:0071456 cellular response to hypoxia 2/308 151/18722 0.713216624302346 0.76247962939258 BNIP3L/EGR1 2 GO:0051604 protein maturation 4/308 294/18722 0.715738677879194 0.764882694680959 SRGN/CASP1/SEC11A/CTSH 4 GO:0008643 carbohydrate transport 2/308 152/18722 0.716620685934133 0.764882694680959 IL1B/HK2 2 GO:0021915 neural tube development 2/308 152/18722 0.716620685934133 0.764882694680959 RALA/HES1 2 GO:0050871 positive regulation of B cell activation 2/308 152/18722 0.716620685934133 0.764882694680959 GPR183/TNFSF13B 2 GO:0006305 DNA alkylation 1/308 76/18722 0.717265095587559 0.764882694680959 FOS 1 GO:0006306 DNA methylation 1/308 76/18722 0.717265095587559 0.764882694680959 FOS 1 GO:0009123 nucleoside monophosphate metabolic process 1/308 76/18722 0.717265095587559 0.764882694680959 TYMP 1 GO:0032720 negative regulation of tumor necrosis factor production 1/308 76/18722 0.717265095587559 0.764882694680959 TNFAIP3 1 GO:0140115 export across plasma membrane 1/308 76/18722 0.717265095587559 0.764882694680959 CALM1 1 GO:0046777 protein autophosphorylation 3/308 227/18722 0.724495958365072 0.772378150816975 EIF2AK2/EGFR/CALM1 3 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1/308 78/18722 0.726528789846936 0.772929024925934 RGS1 1 GO:0008306 associative learning 1/308 78/18722 0.726528789846936 0.772929024925934 FOS 1 GO:0019319 hexose biosynthetic process 1/308 78/18722 0.726528789846936 0.772929024925934 ATF3 1 GO:0035050 embryonic heart tube development 1/308 78/18722 0.726528789846936 0.772929024925934 HES1 1 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 1/308 78/18722 0.726528789846936 0.772929024925934 TNFAIP3 1 GO:0010970 transport along microtubule 2/308 155/18722 0.726630111321948 0.772929024925934 HNRNPU/UBB 2 GO:0046434 organophosphate catabolic process 2/308 155/18722 0.726630111321948 0.772929024925934 TYMP/APOC1 2 GO:0051147 regulation of muscle cell differentiation 2/308 155/18722 0.726630111321948 0.772929024925934 SOD2/BHLHE41 2 GO:0006023 aminoglycan biosynthetic process 1/308 79/18722 0.731046550666886 0.776978305031833 IL1B 1 GO:0050772 positive regulation of axonogenesis 1/308 79/18722 0.731046550666886 0.776978305031833 FN1 1 GO:0060420 regulation of heart growth 1/308 79/18722 0.731046550666886 0.776978305031833 BASP1 1 GO:0070646 protein modification by small protein removal 2/308 157/18722 0.733136036844163 0.778982509409459 TNFAIP3/OTUD1 2 GO:0001654 eye development 5/308 371/18722 0.733513133146097 0.779166631847049 KLF4/FBN2/SERPINF1/HMGB1/FBN1 5 GO:0051056 regulation of small GTPase mediated signal transduction 4/308 302/18722 0.735078239588667 0.780612252763187 SWAP70/TAGAP/RAC1/APOE 4 GO:0001570 vasculogenesis 1/308 80/18722 0.735489916133527 0.780832532457227 JUNB 1 GO:0001523 retinoid metabolic process 1/308 81/18722 0.739860107412943 0.784383025690428 SCPEP1 1 GO:0001942 hair follicle development 1/308 81/18722 0.739860107412943 0.784383025690428 EGFR 1 GO:0051149 positive regulation of muscle cell differentiation 1/308 81/18722 0.739860107412943 0.784383025690428 SOD2 1 GO:1903533 regulation of protein targeting 1/308 81/18722 0.739860107412943 0.784383025690428 BNIP3L 1 GO:2001021 negative regulation of response to DNA damage stimulus 1/308 81/18722 0.739860107412943 0.784383025690428 BID 1 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 3/308 233/18722 0.740644971770015 0.784997429186794 RGS1/PTGER4/CXCL10 3 GO:0018108 peptidyl-tyrosine phosphorylation 5/308 375/18722 0.741989844970415 0.786204871763276 NCF1/EIF2AK2/EGFR/SOCS3/HES1 5 GO:0035082 axoneme assembly 1/308 82/18722 0.744158325690762 0.787629368525964 UBE2B 1 GO:0043242 negative regulation of protein-containing complex disassembly 1/308 82/18722 0.744158325690762 0.787629368525964 SWAP70 1 GO:0046364 monosaccharide biosynthetic process 1/308 82/18722 0.744158325690762 0.787629368525964 ATF3 1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 1/308 82/18722 0.744158325690762 0.787629368525964 RNASET2 1 GO:0036294 cellular response to decreased oxygen levels 2/308 161/18722 0.745754252562217 0.789100057444051 BNIP3L/EGR1 2 GO:0018212 peptidyl-tyrosine modification 5/308 378/18722 0.748216971181924 0.791008772960996 NCF1/EIF2AK2/EGFR/SOCS3/HES1 5 GO:0001510 RNA methylation 1/308 83/18722 0.748385752498018 0.791008772960996 LARP7 1 GO:0050886 endocrine process 1/308 83/18722 0.748385752498018 0.791008772960996 IL1B 1 GO:1901292 nucleoside phosphate catabolic process 1/308 83/18722 0.748385752498018 0.791008772960996 TYMP 1 GO:0006835 dicarboxylic acid transport 1/308 84/18722 0.752543550031716 0.793866995521868 SNCA 1 GO:0022404 molting cycle process 1/308 84/18722 0.752543550031716 0.793866995521868 EGFR 1 GO:0022405 hair cycle process 1/308 84/18722 0.752543550031716 0.793866995521868 EGFR 1 GO:0042310 vasoconstriction 1/308 84/18722 0.752543550031716 0.793866995521868 EGFR 1 GO:0042440 pigment metabolic process 1/308 84/18722 0.752543550031716 0.793866995521868 BLVRA 1 GO:0061157 mRNA destabilization 1/308 84/18722 0.752543550031716 0.793866995521868 ZFP36 1 GO:0097061 dendritic spine organization 1/308 84/18722 0.752543550031716 0.793866995521868 APOE 1 GO:0007018 microtubule-based movement 5/308 382/18722 0.756346593211648 0.796642090168143 UBE2B/DNAJA1/HNRNPU/UBB/DEFB1 5 GO:0030433 ubiquitin-dependent ERAD pathway 1/308 85/18722 0.756632861470188 0.796642090168143 HERPUD1 1 GO:0055013 cardiac muscle cell development 1/308 85/18722 0.756632861470188 0.796642090168143 HNRNPU 1 GO:0060021 roof of mouth development 1/308 85/18722 0.756632861470188 0.796642090168143 ANP32B 1 GO:0072384 organelle transport along microtubule 1/308 85/18722 0.756632861470188 0.796642090168143 UBB 1 GO:0098773 skin epidermis development 1/308 85/18722 0.756632861470188 0.796642090168143 EGFR 1 GO:2000779 regulation of double-strand break repair 1/308 85/18722 0.756632861470188 0.796642090168143 PPP4C 1 GO:0006644 phospholipid metabolic process 5/308 383/18722 0.75834817304959 0.798228266951702 SNCA/PLSCR1/SOCS3/ISYNA1/APOC1 5 GO:0022412 cellular process involved in reproduction in multicellular organism 5/308 384/18722 0.760337458278278 0.800101872556525 UBE2B/HMGB2/CD9/UBB/DEFB1 5 GO:0009798 axis specification 1/308 86/18722 0.760654811283311 0.800215559586158 BASP1 1 GO:0048041 focal adhesion assembly 1/308 87/18722 0.764610505537697 0.803271767702835 RAC1 1 GO:0061014 positive regulation of mRNA catabolic process 1/308 87/18722 0.764610505537697 0.803271767702835 ZFP36 1 GO:0150104 transport across blood-brain barrier 1/308 87/18722 0.764610505537697 0.803271767702835 APOE 1 GO:1901879 regulation of protein depolymerization 1/308 87/18722 0.764610505537697 0.803271767702835 SWAP70 1 GO:2000177 regulation of neural precursor cell proliferation 1/308 87/18722 0.764610505537697 0.803271767702835 NAP1L1 1 GO:0016358 dendrite development 3/308 243/18722 0.765883595822602 0.804388183195002 YWHAH/PHACTR1/APOE 3 GO:0099173 postsynapse organization 2/308 168/18722 0.76660813416551 0.804928013434426 SRGN/APOE 2 GO:0001843 neural tube closure 1/308 88/18722 0.768501032196908 0.806251220112179 RALA 1 GO:0010232 vascular transport 1/308 88/18722 0.768501032196908 0.806251220112179 APOE 1 GO:0050779 RNA destabilization 1/308 88/18722 0.768501032196908 0.806251220112179 ZFP36 1 GO:0021543 pallium development 2/308 169/18722 0.769463122505141 0.807039099406626 PHACTR1/BCL2A1 2 GO:0030178 negative regulation of Wnt signaling pathway 2/308 170/18722 0.77228773638719 0.809155353520527 EGR1/APOE 2 GO:0014910 regulation of smooth muscle cell migration 1/308 89/18722 0.772327461416794 0.809155353520527 TRIB1 1 GO:0051781 positive regulation of cell division 1/308 89/18722 0.772327461416794 0.809155353520527 IL1B 1 GO:0060606 tube closure 1/308 89/18722 0.772327461416794 0.809155353520527 RALA 1 GO:0003007 heart morphogenesis 3/308 246/18722 0.773055945027375 0.80969667886018 LY6E/DSP/HES1 3 GO:0006400 tRNA modification 1/308 90/18722 0.77609084583603 0.811763420966113 SSB 1 GO:0034644 cellular response to UV 1/308 90/18722 0.77609084583603 0.811763420966113 NPM1 1 GO:0035278 miRNA mediated inhibition of translation 1/308 90/18722 0.77609084583603 0.811763420966113 ZFP36 1 GO:0040033 negative regulation of translation, ncRNA-mediated 1/308 90/18722 0.77609084583603 0.811763420966113 ZFP36 1 GO:0061097 regulation of protein tyrosine kinase activity 1/308 90/18722 0.77609084583603 0.811763420966113 NCF1 1 GO:1901136 carbohydrate derivative catabolic process 2/308 172/18722 0.777846732829679 0.813377478010904 TYMP/APOBEC3A 2 GO:0043010 camera-type eye development 4/308 322/18722 0.779074040449608 0.814438079474666 KLF4/FBN2/SERPINF1/FBN1 4 GO:0045974 regulation of translation, ncRNA-mediated 1/308 91/18722 0.779792220861926 0.814520672228182 ZFP36 1 GO:0051952 regulation of amine transport 1/308 91/18722 0.779792220861926 0.814520672228182 SNCA 1 GO:0055006 cardiac cell development 1/308 91/18722 0.779792220861926 0.814520672228182 HNRNPU 1 GO:0031058 positive regulation of histone modification 1/308 92/18722 0.78343260495159 0.817206780008166 IL1B 1 GO:0032465 regulation of cytokinesis 1/308 92/18722 0.78343260495159 0.817206780008166 CALM1 1 GO:0034502 protein localization to chromosome 1/308 92/18722 0.78343260495159 0.817206780008166 IK 1 GO:0035249 synaptic transmission, glutamatergic 1/308 92/18722 0.78343260495159 0.817206780008166 EGFR 1 GO:0070509 calcium ion import 1/308 92/18722 0.78343260495159 0.817206780008166 CCL3 1 GO:0006302 double-strand break repair 3/308 251/18722 0.784610612286118 0.818212321541143 HMGB2/PPP4C/HMGB1 3 GO:1905475 regulation of protein localization to membrane 2/308 175/18722 0.78596301643535 0.819399130578768 GBP1/EGFR 2 GO:0045132 meiotic chromosome segregation 1/308 93/18722 0.787012999888515 0.819823078630461 UBE2B 1 GO:0090398 cellular senescence 1/308 93/18722 0.787012999888515 0.819823078630461 B2M 1 GO:0106027 neuron projection organization 1/308 93/18722 0.787012999888515 0.819823078630461 APOE 1 GO:0008654 phospholipid biosynthetic process 3/308 253/18722 0.789094882080799 0.821767838244318 PLSCR1/SOCS3/ISYNA1 3 GO:0001738 morphogenesis of a polarized epithelium 1/308 94/18722 0.790534391054672 0.822594713391946 RAC1 1 GO:0010389 regulation of G2/M transition of mitotic cell cycle 1/308 94/18722 0.790534391054672 0.822594713391946 SYF2 1 GO:0014020 primary neural tube formation 1/308 94/18722 0.790534391054672 0.822594713391946 RALA 1 GO:0071453 cellular response to oxygen levels 2/308 177/18722 0.791228366412981 0.823092801305259 BNIP3L/EGR1 2 GO:0035265 organ growth 2/308 178/18722 0.793818070453681 0.825075669869563 LY6E/BASP1 2 GO:0002532 production of molecular mediator involved in inflammatory response 1/308 95/18722 0.793997747698174 0.825075669869563 NCF1 1 GO:0042982 amyloid precursor protein metabolic process 1/308 95/18722 0.793997747698174 0.825075669869563 APOE 1 GO:1901379 regulation of potassium ion transmembrane transport 1/308 95/18722 0.793997747698174 0.825075669869563 VAMP2 1 GO:0048638 regulation of developmental growth 4/308 330/18722 0.794980095614225 0.825871985199235 CXCR4/BASP1/APOE/FN1 4 GO:0090596 sensory organ morphogenesis 3/308 256/18722 0.795676242958734 0.82637062668602 FBN2/MAFB/FBN1 3 GO:0007416 synapse assembly 2/308 179/18722 0.796379430690315 0.826876307313708 SNCA/SDCBP 2 GO:0003073 regulation of systemic arterial blood pressure 1/308 96/18722 0.797404023196588 0.827041665946977 SOD2 1 GO:0042158 lipoprotein biosynthetic process 1/308 96/18722 0.797404023196588 0.827041665946977 APOE 1 GO:0042472 inner ear morphogenesis 1/308 96/18722 0.797404023196588 0.827041665946977 MAFB 1 GO:0042632 cholesterol homeostasis 1/308 96/18722 0.797404023196588 0.827041665946977 APOE 1 GO:0045165 cell fate commitment 3/308 258/18722 0.799968266596346 0.829391258675948 KLF4/MCL1/HES1 3 GO:0014909 smooth muscle cell migration 1/308 97/18722 0.800754155315962 0.829391258675948 TRIB1 1 GO:0035335 peptidyl-tyrosine dephosphorylation 1/308 97/18722 0.800754155315962 0.829391258675948 DUSP1 1 GO:0043255 regulation of carbohydrate biosynthetic process 1/308 97/18722 0.800754155315962 0.829391258675948 SNCA 1 GO:0055092 sterol homeostasis 1/308 97/18722 0.800754155315962 0.829391258675948 APOE 1 GO:0043502 regulation of muscle adaptation 1/308 98/18722 0.804049066465636 0.832578434750305 KLF4 1 GO:0051321 meiotic cell cycle 3/308 261/18722 0.806264983572763 0.834646908258509 DUSP1/UBE2B/UBB 3 GO:0007631 feeding behavior 1/308 99/18722 0.807289663948915 0.834803458284204 FOS 1 GO:0015837 amine transport 1/308 99/18722 0.807289663948915 0.834803458284204 SNCA 1 GO:0051153 regulation of striated muscle cell differentiation 1/308 99/18722 0.807289663948915 0.834803458284204 BHLHE41 1 GO:0060996 dendritic spine development 1/308 99/18722 0.807289663948915 0.834803458284204 APOE 1 GO:0060079 excitatory postsynaptic potential 1/308 100/18722 0.810476840209654 0.837872623072338 SNCA 1 GO:0140013 meiotic nuclear division 2/308 185/18722 0.811165148344729 0.838357491787483 UBE2B/UBB 2 GO:0006790 sulfur compound metabolic process 4/308 339/18722 0.811763952495734 0.838749619024646 SNCA/MPC2/COMT/SMS 4 GO:0034660 ncRNA metabolic process 6/308 485/18722 0.812684354624682 0.839473733512607 RPS28/SBDS/SSB/LARP7/RPS27/RPS15 6 GO:0120032 regulation of plasma membrane bounded cell projection assembly 2/308 186/18722 0.813534491327838 0.839750718565091 RALA/RAC1 2 GO:0006476 protein deacetylation 1/308 101/18722 0.813611473074836 0.839750718565091 BEX4 1 GO:0051963 regulation of synapse assembly 1/308 101/18722 0.813611473074836 0.839750718565091 SNCA 1 GO:0001841 neural tube formation 1/308 102/18722 0.816694425993205 0.842023406303135 RALA 1 GO:0006672 ceramide metabolic process 1/308 102/18722 0.816694425993205 0.842023406303135 ASAH1 1 GO:0034308 primary alcohol metabolic process 1/308 102/18722 0.816694425993205 0.842023406303135 ALDH2 1 GO:1990542 mitochondrial transmembrane transport 1/308 102/18722 0.816694425993205 0.842023406303135 MPC2 1 GO:0060491 regulation of cell projection assembly 2/308 188/18722 0.818193850229719 0.843341895235432 RALA/RAC1 2 GO:0003279 cardiac septum development 1/308 103/18722 0.819726548270009 0.844238845376144 HES1 1 GO:0030148 sphingolipid biosynthetic process 1/308 103/18722 0.819726548270009 0.844238845376144 ASAH1 1 GO:0050773 regulation of dendrite development 1/308 103/18722 0.819726548270009 0.844238845376144 YWHAH 1 GO:0046578 regulation of Ras protein signal transduction 2/308 189/18722 0.820484321336503 0.844791694174374 RAC1/APOE 2 GO:0032006 regulation of TOR signaling 1/308 104/18722 0.822708675297929 0.846211799994881 DDIT4 1 GO:0060419 heart growth 1/308 104/18722 0.822708675297929 0.846211799994881 BASP1 1 GO:1901890 positive regulation of cell junction assembly 1/308 104/18722 0.822708675297929 0.846211799994881 RAC1 1 GO:0099111 microtubule-based transport 2/308 190/18722 0.822748956468996 0.846211799994881 HNRNPU/UBB 2 GO:0000041 transition metal ion transport 1/308 105/18722 0.825641628784245 0.848958565584231 B2M 1 GO:0006766 vitamin metabolic process 1/308 106/18722 0.828526216974311 0.851009061658461 CBR1 1 GO:0046620 regulation of organ growth 1/308 106/18722 0.828526216974311 0.851009061658461 BASP1 1 GO:0099565 chemical synaptic transmission, postsynaptic 1/308 106/18722 0.828526216974311 0.851009061658461 SNCA 1 GO:1905477 positive regulation of protein localization to membrane 1/308 106/18722 0.828526216974311 0.851009061658461 EGFR 1 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2/308 193/18722 0.829390110892652 0.851667578281657 NCF1/HES1 2 GO:0021761 limbic system development 1/308 107/18722 0.831363234871384 0.852320098394556 UBB 1 GO:0036503 ERAD pathway 1/308 107/18722 0.831363234871384 0.852320098394556 HERPUD1 1 GO:0042303 molting cycle 1/308 107/18722 0.831363234871384 0.852320098394556 EGFR 1 GO:0042633 hair cycle 1/308 107/18722 0.831363234871384 0.852320098394556 EGFR 1 GO:0071868 cellular response to monoamine stimulus 1/308 107/18722 0.831363234871384 0.852320098394556 SNCA 1 GO:0071870 cellular response to catecholamine stimulus 1/308 107/18722 0.831363234871384 0.852320098394556 SNCA 1 GO:1901605 alpha-amino acid metabolic process 2/308 195/18722 0.833692511036898 0.854478946298676 COMT/SMS 2 GO:0006821 chloride transport 1/308 109/18722 0.836897674883125 0.857304343804444 FXYD3 1 GO:0043266 regulation of potassium ion transport 1/308 109/18722 0.836897674883125 0.857304343804444 VAMP2 1 GO:0015711 organic anion transport 4/308 354/18722 0.837235918632596 0.857421086775359 SNCA/MPC2/IL1B/ANXA1 4 GO:0007281 germ cell development 3/308 278/18722 0.838873513472412 0.858868088378423 UBE2B/HMGB2/DEFB1 3 GO:0006805 xenobiotic metabolic process 1/308 111/18722 0.842251052133802 0.86140336337815 CBR1 1 GO:0071867 response to monoamine 1/308 111/18722 0.842251052133802 0.86140336337815 SNCA 1 GO:0071869 response to catecholamine 1/308 111/18722 0.842251052133802 0.86140336337815 SNCA 1 GO:0090288 negative regulation of cellular response to growth factor stimulus 1/308 111/18722 0.842251052133802 0.86140336337815 FBN1 1 GO:0035601 protein deacylation 1/308 112/18722 0.84486169508382 0.863842273416808 BEX4 1 GO:0001578 microtubule bundle formation 1/308 113/18722 0.847429271543475 0.866124310237045 UBE2B 1 GO:0007389 pattern specification process 5/308 436/18722 0.847546702745694 0.866124310237045 BASP1/BHLHE41/MAFB/HES1/C1QA 5 GO:1903046 meiotic cell cycle process 2/308 202/18722 0.847991364793835 0.866347137254631 UBE2B/UBB 2 GO:0051261 protein depolymerization 1/308 114/18722 0.849954489683333 0.868120762505846 SWAP70 1 GO:0042471 ear morphogenesis 1/308 115/18722 0.852438046066476 0.870424853128242 MAFB 1 GO:0030326 embryonic limb morphogenesis 1/308 116/18722 0.85488062583815 0.871987361947504 FBN2 1 GO:0035113 embryonic appendage morphogenesis 1/308 116/18722 0.85488062583815 0.871987361947504 FBN2 1 GO:0043200 response to amino acid 1/308 116/18722 0.85488062583815 0.871987361947504 CEBPB 1 GO:0098732 macromolecule deacylation 1/308 116/18722 0.85488062583815 0.871987361947504 BEX4 1 GO:0046474 glycerophospholipid biosynthetic process 2/308 211/18722 0.864734367116041 0.881803010265304 PLSCR1/SOCS3 2 GO:0030258 lipid modification 2/308 212/18722 0.866486824921522 0.882899107237506 APOE/APOC1 2 GO:0001838 embryonic epithelial tube formation 1/308 121/18722 0.866502079611594 0.882899107237506 RALA 1 GO:0043244 regulation of protein-containing complex disassembly 1/308 121/18722 0.866502079611594 0.882899107237506 SWAP70 1 GO:0044282 small molecule catabolic process 4/308 376/18722 0.869343984801027 0.885558767357934 HK2/ALDH2/APOE/APOBEC3A 4 GO:0044242 cellular lipid catabolic process 2/308 214/18722 0.869929539582632 0.885919187486522 ASAH1/APOC1 2 GO:0071482 cellular response to light stimulus 1/308 123/18722 0.870886578373315 0.886657626929742 NPM1 1 GO:2000027 regulation of animal organ morphogenesis 1/308 125/18722 0.875127528366744 0.890738163191178 RAC1 1 GO:0030198 extracellular matrix organization 3/308 301/18722 0.875394470118931 0.89077270675131 FBLN1/P4HA1/DNAJB6 3 GO:0043062 extracellular structure organization 3/308 302/18722 0.876802325274753 0.891967879064763 FBLN1/P4HA1/DNAJB6 3 GO:0031929 TOR signaling 1/308 126/18722 0.877195642646631 0.89213060437299 DDIT4 1 GO:0006911 phagocytosis, engulfment 1/308 127/18722 0.879229614579564 0.893723694904992 RAC1 1 GO:0008033 tRNA processing 1/308 127/18722 0.879229614579564 0.893723694904992 SSB 1 GO:0045229 external encapsulating structure organization 3/308 304/18722 0.879575901505123 0.893838030689549 FBLN1/P4HA1/DNAJB6 3 GO:0001952 regulation of cell-matrix adhesion 1/308 128/18722 0.881230006013256 0.895280976079904 RAC1 1 GO:0006650 glycerophospholipid metabolic process 3/308 306/18722 0.882294025760259 0.89612382053174 PLSCR1/SOCS3/APOC1 3 GO:0006661 phosphatidylinositol biosynthetic process 1/308 131/18722 0.887035178456624 0.900699996610803 SOCS3 1 GO:0035264 multicellular organism growth 1/308 132/18722 0.888906684294683 0.902121118677614 KLF2 1 GO:0072175 epithelial tube formation 1/308 132/18722 0.888906684294683 0.902121118677614 RALA 1 GO:0046486 glycerolipid metabolic process 4/308 392/18722 0.889144414217354 0.902122902216811 PLSCR1/SOCS3/APOE/APOC1 4 GO:0009581 detection of external stimulus 1/308 135/18722 0.894337789365506 0.907151331585123 CXCR4 1 GO:0043624 cellular protein complex disassembly 1/308 136/18722 0.896088688428045 0.90844525480255 SWAP70 1 GO:0099024 plasma membrane invagination 1/308 136/18722 0.896088688428045 0.90844525480255 RAC1 1 GO:0008203 cholesterol metabolic process 1/308 137/18722 0.89781066647411 0.909708501969394 APOE 1 GO:0060078 regulation of postsynaptic membrane potential 1/308 137/18722 0.89781066647411 0.909708501969394 SNCA 1 GO:0007160 cell-matrix adhesion 2/308 233/18722 0.898793338056163 0.909977389625849 RAC1/FN1 2 GO:0000724 double-strand break repair via homologous recombination 1/308 138/18722 0.899504199685085 0.909977389625849 PPP4C 1 GO:0007224 smoothened signaling pathway 1/308 138/18722 0.899504199685085 0.909977389625849 HES1 1 GO:0009582 detection of abiotic stimulus 1/308 138/18722 0.899504199685085 0.909977389625849 CXCR4 1 GO:0035107 appendage morphogenesis 1/308 138/18722 0.899504199685085 0.909977389625849 FBN2 1 GO:0035108 limb morphogenesis 1/308 138/18722 0.899504199685085 0.909977389625849 FBN2 1 GO:0000725 recombinational repair 1/308 140/18722 0.902807797379788 0.9128363420743 PPP4C 1 GO:0007292 female gamete generation 1/308 140/18722 0.902807797379788 0.9128363420743 UBB 1 GO:0046467 membrane lipid biosynthetic process 1/308 142/18722 0.906003136948454 0.91582495836963 ASAH1 1 GO:0006865 amino acid transport 1/308 143/18722 0.907561319608297 0.917157527058556 SNCA 1 GO:0006813 potassium ion transport 2/308 241/18722 0.909066615120312 0.918435959197926 VAMP2/FXYD3 2 GO:0061351 neural precursor cell proliferation 1/308 145/18722 0.910600866634071 0.919742962521018 NAP1L1 1 GO:0016331 morphogenesis of embryonic epithelium 1/308 147/18722 0.913540781827272 0.921981628544261 RALA 1 GO:0060041 retina development in camera-type eye 1/308 147/18722 0.913540781827272 0.921981628544261 SERPINF1 1 GO:1902652 secondary alcohol metabolic process 1/308 147/18722 0.913540781827272 0.921981628544261 APOE 1 GO:0098656 anion transmembrane transport 2/308 245/18722 0.913830245808258 0.922030358861169 MPC2/VDAC2 2 GO:0035148 tube formation 1/308 148/18722 0.914974399011509 0.922941194570184 RALA 1 GO:1905039 carboxylic acid transmembrane transport 1/308 149/18722 0.916384320681825 0.924119561584441 MPC2 1 GO:1903825 organic acid transmembrane transport 1/308 150/18722 0.917770937234348 0.925273811457519 MPC2 1 GO:0048754 branching morphogenesis of an epithelial tube 1/308 151/18722 0.919134632653894 0.926160174126473 CTSH 1 GO:0055067 monovalent inorganic cation homeostasis 1/308 151/18722 0.919134632653894 0.926160174126473 COMT 1 GO:0016125 sterol metabolic process 1/308 152/18722 0.920475784618926 0.92702289899846 APOE 1 GO:0090501 RNA phosphodiester bond hydrolysis 1/308 152/18722 0.920475784618926 0.92702289899846 RNASET2 1 GO:0045017 glycerolipid biosynthetic process 2/308 252/18722 0.921609024871594 0.927675434987916 PLSCR1/SOCS3 2 GO:0061448 connective tissue development 2/308 252/18722 0.921609024871594 0.927675434987916 EGR1/UBB 2 GO:0050770 regulation of axonogenesis 1/308 154/18722 0.923091937985241 0.928923526959089 FN1 1 GO:0006665 sphingolipid metabolic process 1/308 155/18722 0.924367664132406 0.929962521046891 ASAH1 1 GO:1902600 proton transmembrane transport 1/308 157/18722 0.926856182794919 0.93222078053801 TMSB4X 1 GO:0046488 phosphatidylinositol metabolic process 1/308 159/18722 0.929263079230003 0.934395779036376 SOCS3 1 GO:0051650 establishment of vesicle localization 1/308 161/18722 0.931591022173148 0.936490264992886 SNCA 1 GO:0055088 lipid homeostasis 1/308 167/18722 0.938126529545814 0.942812229877404 APOE 1 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 2/308 273/18722 0.941168753594218 0.945621063072456 KLF4/MYADM 2 GO:0048736 appendage development 1/308 172/18722 0.943094650964094 0.947058274398669 FBN2 1 GO:0060173 limb development 1/308 172/18722 0.943094650964094 0.947058274398669 FBN2 1 GO:0050954 sensory perception of mechanical stimulus 1/308 175/18722 0.94588252591878 0.949608428725708 CXCR4 1 GO:0051648 vesicle localization 1/308 177/18722 0.947665048610935 0.951148196597428 SNCA 1 GO:0016570 histone modification 4/308 463/18722 0.948660927746928 0.951897828550264 SNCA/UBE2B/IL1B/SET 4 GO:0006399 tRNA metabolic process 1/308 179/18722 0.949389042880664 0.952211287326075 SSB 1 GO:0006520 cellular amino acid metabolic process 2/308 284/18722 0.949471469340047 0.952211287326075 COMT/SMS 2 GO:0006575 cellular modified amino acid metabolic process 1/308 188/18722 0.956472649881613 0.958981101625336 PLSCR1 1 GO:0006643 membrane lipid metabolic process 1/308 203/18722 0.966150384674456 0.968430236132786 ASAH1 1 GO:0007601 visual perception 1/308 215/18722 0.972322764987718 0.974361711808137 TIMP3 1 GO:0050953 sensory perception of light stimulus 1/308 219/18722 0.974119878054331 0.975651111816009 TIMP3 1 GO:0071805 potassium ion transmembrane transport 1/308 219/18722 0.974119878054331 0.975651111816009 VAMP2 1 GO:0048705 skeletal system morphogenesis 1/308 220/18722 0.974550677252259 0.975826935341903 FBN2 1 GO:0060271 cilium assembly 2/308 337/18722 0.976081053778478 0.977103395809144 UBE2B/RAB8A 2 GO:0007411 axon guidance 1/308 227/18722 0.977372609122864 0.97788418860945 RAC1 1 GO:0098657 import into cell 1/308 227/18722 0.977372609122864 0.97788418860945 SNCA 1 GO:0097485 neuron projection guidance 1/308 228/18722 0.977749426445933 0.978005247855259 RAC1 1 GO:0044782 cilium organization 2/308 368/18722 0.984706776529136 0.984706776529136 UBE2B/RAB8A 2