ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	23/327	182/18367	1.79957708967245e-13	9.53775857526398e-11	RPL39/RPL17/RPS10/RPS29/RPL34/RPS3A/RPL36A/RPL3/RPL23/RPS15/ISG15/RPL7/RPS15A/RPL18A/RPS28/RPS20/RPL9/RPL5/MRPS21/UBA52/RPS6/MRPL52/RPL36	23
GO:0140297	DNA-binding transcription factor binding	25/327	394/18367	4.4778077615111e-08	1.18661905680044e-05	NFKBIA/FOS/KLF4/JUND/JUN/NR4A2/NR4A1/BHLHE40/HIF1A/YWHAH/PTMA/NLRP3/GABARAPL1/CTNNB1/ID2/DNAJA1/ETS2/DDX5/NPM1/CEBPB/CREM/HES1/NR4A3/HMGB1/MED13	25
GO:0035259	glucocorticoid receptor binding	6/327	14/18367	8.10074816262519e-08	1.34934821777335e-05	NR4A2/NR4A1/YWHAH/ETS2/CEBPB/NR4A3	6
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	21/327	299/18367	1.01837601341385e-07	1.34934821777335e-05	NFKBIA/FOS/KLF4/JUND/JUN/NR4A2/NR4A1/BHLHE40/HIF1A/YWHAH/GABARAPL1/CTNNB1/ID2/DNAJA1/ETS2/DDX5/NPM1/CEBPB/HES1/NR4A3/MED13	21
GO:0005126	cytokine receptor binding	19/327	271/18367	4.29068355768807e-07	4.54812457114935e-05	CXCL8/CCL3/IL1B/CCL4/CCL3L3/VEGFA/CXCL2/TNF/OSM/GRB2/CCRL2/PPBP/LRG1/IL1A/IL1RN/CCL20/PF4/DEFB1/CSH1	19
GO:0042379	chemokine receptor binding	10/327	72/18367	5.62676169908272e-07	4.97030616752307e-05	CXCL8/CCL3/CCL4/CCL3L3/CXCL2/CCRL2/PPBP/CCL20/PF4/DEFB1	10
GO:0005125	cytokine activity	17/327	235/18367	1.13757293925133e-06	8.61305225433152e-05	CXCL8/CCL3/IL1B/CCL4/CCL3L3/VEGFA/CXCL2/TNF/OSM/AREG/PPBP/IL1A/IL1RN/CCL20/SPP1/PF4/HMGB1	17
GO:0008009	chemokine activity	8/327	49/18367	2.21370411068399e-06	0.000137216666065644	CXCL8/CCL3/CCL4/CCL3L3/CXCL2/PPBP/CCL20/PF4	8
GO:0048018	receptor ligand activity	25/327	487/18367	2.3300943294166e-06	0.000137216666065644	CXCL8/CCL3/IL1B/CCL4/METRNL/CCL3L3/VEGFA/CXCL2/TNF/HBEGF/OSM/AREG/HMGB2/PPBP/SEMA4D/EREG/IL1A/IL1RN/CCL20/SPP1/TYMP/PF4/HMGB1/CSH1/RETN	25
GO:0030546	signaling receptor activator activity	25/327	495/18367	3.11029740654345e-06	0.000164845762546803	CXCL8/CCL3/IL1B/CCL4/METRNL/CCL3L3/VEGFA/CXCL2/TNF/HBEGF/OSM/AREG/HMGB2/PPBP/SEMA4D/EREG/IL1A/IL1RN/CCL20/SPP1/TYMP/PF4/HMGB1/CSH1/RETN	25
GO:0044389	ubiquitin-like protein ligase binding	19/327	316/18367	4.23358462660688e-06	0.000203981804736513	NFKBIA/JUN/TRIB1/CXCR4/HIF1A/CDKN1A/GABARAPL1/MAP1LC3B/GABARAP/DNAJA1/HSP90AB1/CEBPB/SUMO2/RPL23/ISG15/RPL5/UBA52/PIAS1/TUBB	19
GO:0023026	MHC class II protein complex binding	6/327	27/18367	6.56695923711432e-06	0.000277269038927506	HSP90AB1/CD81/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-DRB1	6
GO:0031625	ubiquitin protein ligase binding	18/327	297/18367	6.80093869067467e-06	0.000277269038927506	NFKBIA/JUN/TRIB1/CXCR4/HIF1A/CDKN1A/GABARAPL1/MAP1LC3B/GABARAP/DNAJA1/HSP90AB1/SUMO2/RPL23/ISG15/RPL5/UBA52/PIAS1/TUBB	18
GO:0046332	SMAD binding	9/327	79/18367	1.10916864935501e-05	0.000419899560112966	FOS/JUN/CTNNB1/DDX5/TGIF1/SKIL/ZMIZ1/TOB1/RGCC	9
GO:0055106	ubiquitin-protein transferase regulator activity	5/327	22/18367	3.56128724763606e-05	0.00117714688794513	TRIB1/RPL23/RPS15/RPS20/RPL5	5
GO:0023023	MHC protein complex binding	6/327	36/18367	3.77575416888061e-05	0.00117714688794513	HSP90AB1/CD81/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-DRB1	6
GO:0042605	peptide antigen binding	6/327	36/18367	3.77575416888061e-05	0.00117714688794513	HLA-DPB1/HLA-DQA1/HLA-C/HLA-A/HLA-DRA/HLA-DRB1	6
GO:0016922	nuclear receptor binding	11/327	144/18367	5.49049353058399e-05	0.00161664531733862	JUND/NR4A2/NR4A1/HIF1A/YWHAH/CTNNB1/ETS2/DDX5/CEBPB/NR4A3/MED13	11
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21/327	450/18367	6.13013153307251e-05	0.00170998405922549	FOS/FOSB/ATF3/KLF4/JUND/JUN/JUNB/NR4A2/KLF6/NR4A1/HIF1A/CSRNP1/LITAF/FOSL2/KLF10/CEBPB/EGR1/MAFF/NR4A3/CEBPD/STAT6	21
GO:0001216	DNA-binding transcription activator activity	21/327	456/18367	7.39812190360803e-05	0.00196050230445613	FOS/FOSB/ATF3/KLF4/JUND/JUN/JUNB/NR4A2/KLF6/NR4A1/HIF1A/CSRNP1/LITAF/FOSL2/KLF10/CEBPB/EGR1/MAFF/NR4A3/CEBPD/STAT6	21
GO:0043024	ribosomal small subunit binding	4/327	17/18367	0.000195441898314417	0.00478996975842744	EIF1B/PIM1/NPM1/EIF1	4
GO:0048020	CCR chemokine receptor binding	6/327	48/18367	0.000198828933368686	0.00478996975842744	CCL3/CCL4/CCL3L3/CCRL2/CCL20/DEFB1	6
GO:0004857	enzyme inhibitor activity	7/327	70/18367	0.000243802896127994	0.00547163716847629	OAZ1/ANXA5/RPL23/RPS15/RPS20/RPL5/APOC1	7
GO:0045236	CXCR chemokine receptor binding	4/327	18/18367	0.000247772249138549	0.00547163716847629	CXCL8/CXCL2/PPBP/PF4	4
GO:0005178	integrin binding	10/327	144/18367	0.000260687638800136	0.00552657794256288	IL1B/FN1/ICAM1/TLN1/CD81/SPP1/ISG15/FBLN1/HMGB1/THBS1	10
GO:0043021	ribonucleoprotein complex binding	10/327	149/18367	0.000342979961873941	0.00699151460743034	EIF1B/PIM1/SBDS/ETF1/DDX5/NPM1/EIF1/YBX3/HNRNPU/SERBP1	10
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/327	22/18367	0.000559942481720494	0.0108031293586556	BIRC3/PRDX3/SNCA/SERPINB9	4
GO:0030957	Tat protein binding	3/327	10/18367	0.000611497888225786	0.0108031293586556	GABARAPL1/DNAJA1/NPM1	3
GO:0032395	MHC class II receptor activity	3/327	10/18367	0.000611497888225786	0.0108031293586556	HLA-DQA1/HLA-DRA/HLA-DRB1	3
GO:0050786	RAGE receptor binding	3/327	10/18367	0.000611497888225786	0.0108031293586556	HMGB2/S100A8/HMGB1	3
GO:0070412	R-SMAD binding	4/327	23/18367	0.000668384113231132	0.0114272122584677	FOS/JUN/DDX5/RGCC	4
GO:0042608	T cell receptor binding	3/327	11/18367	0.000829750568430857	0.0137427437896361	HLA-A/HLA-DRA/HLA-DRB1	3
GO:0001664	G protein-coupled receptor binding	14/327	295/18367	0.000870813060452795	0.0139857855163631	CXCL8/CCL3/CCL4/CCL3L3/CXCL2/DNAJA1/CCRL2/PRNP/PPBP/CCL20/FCN1/PF4/DEFB1/C3	14
GO:0031386	protein tag	3/327	13/18367	0.00140069851832974	0.021834418079846	SUMO2/ISG15/UBA52	3
GO:0140678	molecular function inhibitor activity	8/327	128/18367	0.00208729583107024	0.0316076225847779	ID2/OAZ1/ANXA5/RPL23/RPS15/RPS20/RPL5/APOC1	8
GO:1990825	sequence-specific mRNA binding	3/327	15/18367	0.00217032844888394	0.0319520577196802	SRSF3/ETF1/SSB	3
GO:0005521	lamin binding	3/327	16/18367	0.00263619482618655	0.0364981283325011	BNIP3L/TMPO/PRNP	3
GO:0005154	epidermal growth factor receptor binding	4/327	33/18367	0.00268571133012744	0.0364981283325011	HBEGF/AREG/GRB2/EREG	4
GO:0019956	chemokine binding	4/327	33/18367	0.00268571133012744	0.0364981283325011	CXCR4/ZFP36/CCRL2/HMGB1	4
GO:0003924	GTPase activity	14/327	337/18367	0.00300716839339327	0.0398449812124609	ARL5B/RAB5C/RGS1/ARL4A/RGS10/ARL4C/EEF1A1/ARL5A/TUBA1A/MX2/GBP4/GBP1/GNG11/TUBB	14
GO:0019207	kinase regulator activity	11/327	233/18367	0.00315893072058784	0.0398662632068382	KLF4/SOCS3/TRIB1/CDKN1A/CCNL1/NPM1/SNCA/HSP90AB1/RGCC/HMGB1/NCKAP1L	11
GO:0005149	interleukin-1 receptor binding	3/327	17/18367	0.00315921331073058	0.0398662632068382	IL1B/IL1A/IL1RN	3
GO:0019887	protein kinase regulator activity	10/327	204/18367	0.00367908707409578	0.0453468871923434	SOCS3/TRIB1/CDKN1A/CCNL1/NPM1/SNCA/HSP90AB1/RGCC/HMGB1/NCKAP1L	10
GO:0070851	growth factor receptor binding	8/327	141/18367	0.0037926496083624	0.0456841884643652	IL1B/VEGFA/HBEGF/AREG/GRB2/EREG/IL1A/IL1RN	8
GO:0042056	chemoattractant activity	4/327	37/18367	0.00409998672668837	0.0482887325587741	CCL3/VEGFA/HMGB2/HMGB1	4
GO:0140375	immune receptor activity	8/327	144/18367	0.00430711607249006	0.0496254677917333	CXCR4/CCRL2/IFNGR2/HLA-DQA1/C5AR1/FPR3/HLA-DRA/HLA-DRB1	8
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	4/327	40/18367	0.00544183241989307	0.0606821673727387	BIRC3/PRDX3/SNCA/SERPINB9	4
GO:0140677	molecular function activator activity	8/327	150/18367	0.00549574346017256	0.0606821673727387	CCL3/DNAJB6/ATP1B3/DNAJA1/NCF2/APOE/APOC1/DAD1	8
GO:0001046	core promoter sequence-specific DNA binding	4/327	42/18367	0.0064825840840063	0.070117746214762	FOS/KLF10/NPM1/CEBPB	4
GO:0008022	protein C-terminus binding	9/327	189/18367	0.00689681775083921	0.0731062681588957	TNFAIP3/FN1/NCL/MAPRE1/PRDX3/CTNNB1/NCF2/FBLN1/PIAS1	9
GO:0019843	rRNA binding	5/327	68/18367	0.00724103467443517	0.0752499681853067	SBDS/NPM1/RPL23/RPL9/RPL5	5
GO:0004860	protein kinase inhibitor activity	5/327	70/18367	0.00816982069186478	0.082934927315024	SOCS3/TRIB1/CDKN1A/NPM1/SNCA	5
GO:0031072	heat shock protein binding	7/327	129/18367	0.00837250325000396	0.082934927315024	HIF1A/DNAJB6/ZFP36/DNAJA1/SNCA/HSP90AB1/GBP1	7
GO:0019957	C-C chemokine binding	3/327	24/18367	0.00857808041145325	0.082934927315024	CXCR4/ZFP36/CCRL2	3
GO:0008083	growth factor activity	8/327	162/18367	0.00860645472137041	0.082934927315024	VEGFA/HBEGF/OSM/AREG/PPBP/EREG/TYMP/CSH1	8
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	12/327	310/18367	0.00992424600484785	0.0939258996887386	ATF3/JUN/BHLHE40/NFIL3/BCL6/ETS2/MXD1/TGIF1/SKIL/CEBPB/CREM/HES1	12
GO:0019210	kinase inhibitor activity	5/327	74/18367	0.0102691349831348	0.0954849393168671	SOCS3/TRIB1/CDKN1A/NPM1/SNCA	5
GO:0002020	protease binding	7/327	135/18367	0.0106049562353909	0.095711200387881	TNFAIP3/FN1/TNF/PRNP/RIPK2/SERPINB9/TIMP3	7
GO:0001217	DNA-binding transcription repressor activity	12/327	313/18367	0.0106546430620471	0.095711200387881	ATF3/JUN/BHLHE40/NFIL3/BCL6/ETS2/MXD1/TGIF1/SKIL/CEBPB/CREM/HES1	12
GO:0003823	antigen binding	8/327	171/18367	0.0116898553295242	0.101899648061482	CD48/FCN1/HLA-DPB1/HLA-DQA1/HLA-C/HLA-A/HLA-DRA/HLA-DRB1	8
GO:0001671	ATPase activator activity	3/327	27/18367	0.0119203361883244	0.101899648061482	DNAJB6/ATP1B3/DNAJA1	3
GO:0048027	mRNA 5'-UTR binding	3/327	27/18367	0.0119203361883244	0.101899648061482	NCL/RPS3A/RPL5	3
GO:0051087	chaperone binding	6/327	107/18367	0.0122530312577905	0.101988560819163	FN1/DNAJB6/DNAJA1/PRNP/ERP29/HES1	6
GO:0019955	cytokine binding	7/327	139/18367	0.012315599797031	0.101988560819163	CXCR4/ZFP36/CCRL2/IL1RN/GBP1/HMGB1/THBS1	7
GO:0042277	peptide binding	12/327	321/18367	0.0128063764263256	0.102353922848444	NFKBIA/PPIF/PRNP/HSP90AB1/HLA-DPB1/HLA-DQA1/APOE/HLA-C/HLA-A/HLA-DRA/HLA-DRB1/PPP3CA	12
GO:0033218	amide binding	14/327	400/18367	0.012850840259085	0.102353922848444	NFKBIA/PPIF/MAP1LC3B/VDAC2/PRNP/HSP90AB1/HLA-DPB1/HLA-DQA1/APOE/HLA-C/HLA-A/HLA-DRA/HLA-DRB1/PPP3CA	14
GO:0008330	protein tyrosine/threonine phosphatase activity	2/327	10/18367	0.0129390808129164	0.102353922848444	DUSP2/DUSP1	2
GO:0001968	fibronectin binding	3/327	28/18367	0.013177858739947	0.102709781355469	VEGFA/FBLN1/THBS1	3
GO:0003712	transcription coregulator activity	16/327	489/18367	0.0147093807626417	0.112985098611596	CTNNB1/AKIRIN2/HMGB2/BTG1/NPM1/TLE3/BASP1/NMI/HNRNPU/ZMIZ1/TOB1/TRIM22/PAGE4/HMGB1/MED13/PIAS1	16
GO:0051400	BH domain binding	2/327	11/18367	0.0156300430894688	0.115054483853034	BCL2A1/MCL1	2
GO:0097371	MDM2/MDM4 family protein binding	2/327	11/18367	0.0156300430894688	0.115054483853034	RPS15/RPS20	2
GO:1990226	histone methyltransferase binding	2/327	11/18367	0.0156300430894688	0.115054483853034	CTNNB1/HSP90AB1	2
GO:0008135	translation factor activity, RNA binding	5/327	84/18367	0.0170661181059467	0.123904693097969	EIF1B/ETF1/EIF1/EIF1AX/EEF1A1	5
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/327	56/18367	0.0175362096512303	0.125597177231785	BIRC3/PRDX3/SNCA/SERPINB9	4
GO:0019903	protein phosphatase binding	7/327	150/18367	0.0180342139175424	0.125921752913587	PPP1R15A/PHACTR1/GRB2/CTNNB1/IRS2/SNX3/STAT6	7
GO:0005525	GTP binding	13/327	377/18367	0.0180567041913823	0.125921752913587	ARL5B/RAB5C/ARL4A/HSP90AB1/ARL4C/EEF1A1/ARL5A/TUBA1A/MX2/GBP4/IFI44L/GBP1/TUBB	13
GO:0004875	complement receptor activity	2/327	12/18367	0.0185376926258257	0.127068633473674	C5AR1/FPR3	2
GO:0016209	antioxidant activity	5/327	86/18367	0.0187126160879022	0.127068633473674	SOD2/PRDX3/PTGS2/HBG1/APOE	5
GO:0071889	14-3-3 protein binding	3/327	32/18367	0.0189404189517363	0.127068633473674	DDIT4/ZFP36/IRS2	3
GO:0003727	single-stranded RNA binding	5/327	87/18367	0.0195737208697582	0.129675900762148	HNRNPA1/HNRNPF/HNRNPU/SSB/HMGB1	5
GO:0036002	pre-mRNA binding	4/327	59/18367	0.020853888348812	0.136451368208276	HNRNPA1/RNU11/DDX5/HNRNPU	4
GO:0004859	phospholipase inhibitor activity	2/327	13/18367	0.0216535097362795	0.136623335240811	ANXA5/APOC1	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/327	13/18367	0.0216535097362795	0.136623335240811	PRDX3/PGK1	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/327	13/18367	0.0216535097362795	0.136623335240811	DUSP2/DUSP1	2
GO:0005539	glycosaminoglycan binding	9/327	230/18367	0.0224130732887553	0.138127079570236	FN1/VEGFA/NLRP3/HBEGF/PRNP/APOE/PF4/THBS1/AOC1	9
GO:0061134	peptidase regulator activity	9/327	230/18367	0.0224130732887553	0.138127079570236	FN1/BIRC3/PRDX3/PRNP/SNCA/SERPINB9/TIMP3/C3/FBLN1	9
GO:0005507	copper ion binding	4/327	61/18367	0.0232654526592132	0.141732067923942	PRNP/SNCA/IL1A/AOC1	4
GO:1990841	promoter-specific chromatin binding	4/327	62/18367	0.0245320869496959	0.14775006912885	KLF4/DDX5/HNRNPU/EGR1	4
GO:0043394	proteoglycan binding	3/327	36/18367	0.0258880728574004	0.152451984604691	FN1/APOE/THBS1	3
GO:0097718	disordered domain specific binding	3/327	36/18367	0.0258880728574004	0.152451984604691	FN1/CTNNB1/HSP90AB1	3
GO:0019001	guanyl nucleotide binding	13/327	398/18367	0.0266544577661391	0.153552854522323	ARL5B/RAB5C/ARL4A/HSP90AB1/ARL4C/EEF1A1/ARL5A/TUBA1A/MX2/GBP4/IFI44L/GBP1/TUBB	13
GO:0032561	guanyl ribonucleotide binding	13/327	398/18367	0.0266544577661391	0.153552854522323	ARL5B/RAB5C/ARL4A/HSP90AB1/ARL4C/EEF1A1/ARL5A/TUBA1A/MX2/GBP4/IFI44L/GBP1/TUBB	13
GO:0008201	heparin binding	7/327	166/18367	0.0293528067559229	0.167279436350958	FN1/VEGFA/HBEGF/APOE/PF4/THBS1/AOC1	7
GO:0044325	transmembrane transporter binding	6/327	133/18367	0.0318625852156331	0.179464875466895	YWHAH/PDE4B/CTNNB1/ID2/PRNP/HSP90AB1	6
GO:0035497	cAMP response element binding	2/327	16/18367	0.0321682323950095	0.179464875466895	JUN/NR4A3	2
GO:0000400	four-way junction DNA binding	2/327	17/18367	0.0360361016062467	0.197994589488181	HMGB2/HMGB1	2
GO:0048487	beta-tubulin binding	3/327	41/18367	0.0362367456233085	0.197994589488181	GABARAPL1/GABARAP/SNCA	3
GO:0031490	chromatin DNA binding	5/327	103/18367	0.036987264665378	0.200033166047452	KDM6B/BCL6/HMGN2/HNRNPU/HMGN1	5
GO:0008301	DNA binding, bending	2/327	18/18367	0.0400729266166464	0.208222069674731	HMGB2/HMGB1	2
GO:0033549	MAP kinase phosphatase activity	2/327	18/18367	0.0400729266166464	0.208222069674731	DUSP2/DUSP1	2
GO:0050811	GABA receptor binding	2/327	18/18367	0.0400729266166464	0.208222069674731	GABARAPL1/GABARAP	2
GO:0055102	lipase inhibitor activity	2/327	18/18367	0.0400729266166464	0.208222069674731	ANXA5/APOC1	2
GO:0004866	endopeptidase inhibitor activity	7/327	180/18367	0.0425493404359218	0.218943208068335	BIRC3/PRDX3/PRNP/SNCA/SERPINB9/TIMP3/C3	7
GO:0001784	phosphotyrosine residue binding	3/327	44/18367	0.0433183667894107	0.220757061522959	SOCS3/GRB2/SAMSN1	3
GO:0090079	translation regulator activity, nucleic acid binding	5/327	108/18367	0.0439010914275977	0.221595985301207	EIF1B/ETF1/EIF1/EIF1AX/EEF1A1	5
GO:0048156	tau protein binding	3/327	45/18367	0.0458212369127914	0.229106184563957	SNCA/HSP90AB1/APOE	3
GO:0008047	enzyme activator activity	5/327	110/18367	0.0468692709279685	0.232156201792741	CCL3/NCF2/APOE/APOC1/DAD1	5
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/327	20/18367	0.0486248366293525	0.232172643365377	FOS/CEBPB	2
GO:0016018	cyclosporin A binding	2/327	20/18367	0.0486248366293525	0.232172643365377	PPIF/PPP3CA	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/327	20/18367	0.0486248366293525	0.232172643365377	KLF4/SOCS3	2
GO:0097001	ceramide binding	2/327	20/18367	0.0486248366293525	0.232172643365377	MAP1LC3B/VDAC2	2
GO:0030414	peptidase inhibitor activity	7/327	187/18367	0.0503903195819718	0.236693365204992	BIRC3/PRDX3/PRNP/SNCA/SERPINB9/TIMP3/C3	7
GO:0001221	transcription coregulator binding	4/327	78/18367	0.0504648118267246	0.236693365204992	KLF4/HIF1A/CTNNB1/RPL23	4
GO:0003779	actin binding	13/327	440/18367	0.0522802081610963	0.243057108117378	TMSB4X/PHACTR1/CXCR4/YWHAH/FRG1/SNCA/MARCKSL1/TLN1/HNRNPU/TPM3/MARCKS/COTL1/GBP1	13
GO:0070888	E-box binding	3/327	48/18367	0.0537475241821322	0.247705981013305	BHLHE40/HIF1A/HES1	3
GO:0005355	glucose transmembrane transporter activity	2/327	22/18367	0.0577687337722174	0.257289318481304	PPBP/SLC2A3	2
GO:0008320	protein transmembrane transporter activity	2/327	22/18367	0.0577687337722174	0.257289318481304	MCL1/TOMM22	2
GO:0015149	hexose transmembrane transporter activity	2/327	22/18367	0.0577687337722174	0.257289318481304	PPBP/SLC2A3	2
GO:0070182	DNA polymerase binding	2/327	22/18367	0.0577687337722174	0.257289318481304	HSP90AB1/HMGB1	2
GO:0061135	endopeptidase regulator activity	7/327	194/18367	0.0590902498221371	0.260981936714439	BIRC3/PRDX3/PRNP/SNCA/SERPINB9/TIMP3/C3	7
GO:0019902	phosphatase binding	7/327	196/18367	0.0617357601171886	0.265196152900199	PPP1R15A/PHACTR1/GRB2/CTNNB1/IRS2/SNX3/STAT6	7
GO:0003743	translation initiation factor activity	3/327	51/18367	0.0622841118384307	0.265196152900199	EIF1B/EIF1/EIF1AX	3
GO:0004601	peroxidase activity	3/327	51/18367	0.0622841118384307	0.265196152900199	PRDX3/PTGS2/HBG1	3
GO:0016493	C-C chemokine receptor activity	2/327	23/18367	0.062546262476462	0.265196152900199	CXCR4/CCRL2	2
GO:0050750	low-density lipoprotein particle receptor binding	2/327	23/18367	0.062546262476462	0.265196152900199	DNAJA1/APOE	2
GO:0008013	beta-catenin binding	4/327	85/18367	0.0651822047696992	0.268795520664544	KLF4/NR4A2/KDM6B/CTNNB1	4
GO:0004879	nuclear receptor activity	3/327	52/18367	0.0652613116322199	0.268795520664544	NR4A2/NR4A1/NR4A3	3
GO:0098531	ligand-activated transcription factor activity	3/327	52/18367	0.0652613116322199	0.268795520664544	NR4A2/NR4A1/NR4A3	3
GO:0051082	unfolded protein binding	5/327	122/18367	0.0671277161897567	0.268795520664544	DNAJB6/DNAJA1/NPM1/HSP90AB1/NACA	5
GO:0001965	G-protein alpha-subunit binding	2/327	24/18367	0.0674524608460083	0.268795520664544	RGS1/RGS10	2
GO:0015145	monosaccharide transmembrane transporter activity	2/327	24/18367	0.0674524608460083	0.268795520664544	PPBP/SLC2A3	2
GO:0019789	SUMO transferase activity	2/327	24/18367	0.0674524608460083	0.268795520664544	SUMO2/PIAS1	2
GO:0043274	phospholipase binding	2/327	24/18367	0.0674524608460083	0.268795520664544	SRSF3/SNCA	2
GO:0003730	mRNA 3'-UTR binding	7/327	201/18367	0.068662376691348	0.270908517161524	HNRNPA0/ZFP36/DDX5/YBX3/HNRNPU/SERBP1/RPL5	7
GO:0003697	single-stranded DNA binding	5/327	123/18367	0.0690049996543503	0.270908517161524	HNRNPA1/HMGB2/HNRNPU/YBX1/HMGB1	5
GO:0046982	protein heterodimerization activity	10/327	328/18367	0.0697389349326339	0.271288672297903	ATF3/NR4A2/BCL2A1/NR4A1/BHLHE40/HIF1A/MCL1/YWHAH/LSM6/CEBPB	10
GO:0016651	oxidoreductase activity, acting on NAD(P)H	4/327	88/18367	0.0721036775669872	0.271288672297903	NCF2/DCXR/NDUFS5/NDUFA6	4
GO:0051219	phosphoprotein binding	4/327	88/18367	0.0721036775669872	0.271288672297903	SOCS3/GRB2/SAMSN1/SNCA	4
GO:0030247	polysaccharide binding	2/327	25/18367	0.0724812650417555	0.271288672297903	HLA-DRA/HLA-DRB1	2
GO:0035035	histone acetyltransferase binding	2/327	25/18367	0.0724812650417555	0.271288672297903	CEBPB/EGR1	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/327	25/18367	0.0724812650417555	0.271288672297903	HNRNPA0/ZFP36	2
GO:0015631	tubulin binding	11/327	375/18367	0.0732422409163396	0.271288672297903	GABARAPL1/MAPRE1/PDE4B/MAP1LC3B/GABARAP/SBDS/PRNP/SNCA/ARL4C/MX2/S100A8	11
GO:0045296	cadherin binding	10/327	332/18367	0.0742550687208678	0.271288672297903	CHMP2B/MAPRE1/CHMP5/TMPO/LDHA/CTNNB1/TLN1/HSP90AB1/SERBP1/RPL34	10
GO:0019888	protein phosphatase regulator activity	4/327	89/18367	0.0744910040343375	0.271288672297903	PPP1R15A/PHACTR1/PPP1R15B/SET	4
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/327	55/18367	0.0745749365693181	0.271288672297903	PRDX3/PTGS2/HBG1	3
GO:0009055	electron transfer activity	5/327	126/18367	0.0748096392720979	0.271288672297903	CYCS/COX7A2L/NCF2/NDUFS5/NDUFA6	5
GO:0042826	histone deacetylase binding	5/327	127/18367	0.0768018114579514	0.271288672297903	KLF4/HIF1A/HSP90AB1/CEBPB/HES1	5
GO:0001637	G protein-coupled chemoattractant receptor activity	2/327	26/18367	0.0776267851819381	0.271288672297903	CXCR4/CCRL2	2
GO:0004950	chemokine receptor activity	2/327	26/18367	0.0776267851819381	0.271288672297903	CXCR4/CCRL2	2
GO:0008198	ferrous iron binding	2/327	26/18367	0.0776267851819381	0.271288672297903	SNCA/FTH1	2
GO:0045309	protein phosphorylated amino acid binding	3/327	56/18367	0.0778035437533608	0.271288672297903	SOCS3/GRB2/SAMSN1	3
GO:0050840	extracellular matrix binding	3/327	56/18367	0.0778035437533608	0.271288672297903	VEGFA/SPP1/THBS1	3
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	3/327	57/18367	0.0810924852472261	0.280908609026339	DCXR/NDUFS5/NDUFA6	3
GO:0004709	MAP kinase kinase kinase activity	2/327	27/18367	0.0828833011014272	0.281590702459977	MAP3K8/RIPK2	2
GO:0022884	macromolecule transmembrane transporter activity	2/327	27/18367	0.0828833011014272	0.281590702459977	MCL1/TOMM22	2
GO:0051119	sugar transmembrane transporter activity	2/327	27/18367	0.0828833011014272	0.281590702459977	PPBP/SLC2A3	2
GO:0008187	poly-pyrimidine tract binding	2/327	28/18367	0.0882452582061564	0.296012574995335	HNRNPU/SSB	2
GO:0070325	lipoprotein particle receptor binding	2/327	28/18367	0.0882452582061564	0.296012574995335	DNAJA1/APOE	2
GO:0001786	phosphatidylserine binding	3/327	60/18367	0.0913107079036688	0.302466719930903	TLN1/HMGB1/THBS1	3
GO:0032934	sterol binding	3/327	60/18367	0.0913107079036688	0.302466719930903	GPR183/VDAC2/CD81	3
GO:0046625	sphingolipid binding	2/327	29/18367	0.0937072634206429	0.306573145758894	MAP1LC3B/VDAC2	2
GO:0051059	NF-kappaB binding	2/327	29/18367	0.0937072634206429	0.306573145758894	NFKBIA/NPM1	2
GO:0003713	transcription coactivator activity	8/327	262/18367	0.0973577008671738	0.316561849445412	CTNNB1/HMGB2/NPM1/ZMIZ1/TRIM22/PAGE4/HMGB1/MED13	8
GO:0008157	protein phosphatase 1 binding	2/327	31/18367	0.104910629790832	0.330047099082463	PPP1R15A/PHACTR1	2
GO:0031210	phosphatidylcholine binding	2/327	31/18367	0.104910629790832	0.330047099082463	VDAC2/APOC1	2
GO:0071813	lipoprotein particle binding	2/327	31/18367	0.104910629790832	0.330047099082463	APOE/THBS1	2
GO:0071814	protein-lipid complex binding	2/327	31/18367	0.104910629790832	0.330047099082463	APOE/THBS1	2
GO:0140318	protein transporter activity	2/327	31/18367	0.104910629790832	0.330047099082463	MCL1/TOMM22	2
GO:0045182	translation regulator activity	5/327	140/18367	0.105241433481012	0.330047099082463	EIF1B/ETF1/EIF1/EIF1AX/EEF1A1	5
GO:0030295	protein kinase activator activity	4/327	101/18367	0.106133772241038	0.330887642869118	CDKN1A/RGCC/HMGB1/NCKAP1L	4
GO:0030145	manganese ion binding	3/327	65/18367	0.109446281707287	0.339219469619075	SOD2/PIM1/LAP3	3
GO:0001223	transcription coactivator binding	2/327	32/18367	0.110641977180105	0.340931673868929	HIF1A/RPL23	2
GO:0005200	structural constituent of cytoskeleton	4/327	103/18367	0.111918968906367	0.341904331051474	TLN1/TUBA1A/HLA-DRB1/TUBB	4
GO:0008017	microtubule binding	8/327	271/18367	0.11224783698671	0.341904331051474	MAPRE1/MAP1LC3B/GABARAP/SBDS/PRNP/SNCA/MX2/S100A8	8
GO:0043022	ribosome binding	3/327	66/18367	0.113228961491417	0.342921997659722	SBDS/ETF1/SERBP1	3
GO:0003714	transcription corepressor activity	6/327	187/18367	0.117778922485435	0.35467516430273	TLE3/BASP1/HNRNPU/TOB1/TRIM22/PIAS1	6
GO:0035198	miRNA binding	2/327	34/18367	0.122340068087827	0.366329017438127	HNRNPA1/YBX1	2
GO:0019208	phosphatase regulator activity	4/327	107/18367	0.12389714788351	0.366846303789164	PPP1R15A/PHACTR1/PPP1R15B/SET	4
GO:0019209	kinase activator activity	4/327	107/18367	0.12389714788351	0.366846303789164	CDKN1A/RGCC/HMGB1/NCKAP1L	4
GO:0000217	DNA secondary structure binding	2/327	36/18367	0.134321757978328	0.393317854853667	HMGB2/HMGB1	2
GO:0042162	telomeric DNA binding	2/327	36/18367	0.134321757978328	0.393317854853667	NCL/HNRNPA1	2
GO:0032182	ubiquitin-like protein binding	4/327	111/18367	0.136393796681418	0.396532278839119	TNFAIP3/CXCR4/SERBP1/RNF19B	4
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	3/327	72/18367	0.136915862316149	0.396532278839119	COX7A2L/NDUFS5/NDUFA6	3
GO:0070063	RNA polymerase binding	3/327	73/18367	0.141017760639237	0.401824801821483	ANP32B/ZFP36/HNRNPU	3
GO:0106306	protein serine phosphatase activity	3/327	73/18367	0.141017760639237	0.401824801821483	DUSP2/DUSP1/PPP3CA	3
GO:0106307	protein threonine phosphatase activity	3/327	73/18367	0.141017760639237	0.401824801821483	DUSP2/DUSP1/PPP3CA	3
GO:0003725	double-stranded RNA binding	3/327	74/18367	0.145160511390435	0.411417492176099	HSP90AB1/HNRNPU/HMGB1	3
GO:0042393	histone binding	7/327	244/18367	0.146337113098723	0.412546116714484	ANP32B/NPM1/SNCA/DEK/CHD1/SET/NAP1L1	7
GO:0005504	fatty acid binding	2/327	39/18367	0.152751301473311	0.419073729847682	S100A8/APOC1	2
GO:0019825	oxygen binding	2/327	39/18367	0.152751301473311	0.419073729847682	SOD2/HBG1	2
GO:0050997	quaternary ammonium group binding	2/327	39/18367	0.152751301473311	0.419073729847682	VDAC2/APOC1	2
GO:0001618	virus receptor activity	3/327	76/18367	0.153563814423099	0.419073729847682	CXCR4/ICAM1/CD81	3
GO:0140272	exogenous protein binding	3/327	77/18367	0.157821993703725	0.419073729847682	CXCR4/ICAM1/CD81	3
GO:0015144	carbohydrate transmembrane transporter activity	2/327	40/18367	0.159000294824641	0.419073729847682	PPBP/SLC2A3	2
GO:0017080	sodium channel regulator activity	2/327	40/18367	0.159000294824641	0.419073729847682	SGK1/YWHAH	2
GO:0031492	nucleosomal DNA binding	2/327	40/18367	0.159000294824641	0.419073729847682	HMGN2/HMGN1	2
GO:0042287	MHC protein binding	2/327	40/18367	0.159000294824641	0.419073729847682	CD81/TUBB	2
GO:0043014	alpha-tubulin binding	2/327	40/18367	0.159000294824641	0.419073729847682	SNCA/ARL4C	2
GO:0044183	protein folding chaperone	2/327	40/18367	0.159000294824641	0.419073729847682	DNAJB6/HSP90AB1	2
GO:0004955	prostaglandin receptor activity	1/327	10/18367	0.164466671336449	0.419073729847682	PTGER4	1
GO:0008097	5S rRNA binding	1/327	10/18367	0.164466671336449	0.419073729847682	RPL5	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/327	10/18367	0.164466671336449	0.419073729847682	NCF2	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/327	10/18367	0.164466671336449	0.419073729847682	NCF2	1
GO:0019203	carbohydrate phosphatase activity	1/327	10/18367	0.164466671336449	0.419073729847682	PFKFB3	1
GO:0031720	haptoglobin binding	1/327	10/18367	0.164466671336449	0.419073729847682	HBG1	1
GO:0045294	alpha-catenin binding	1/327	10/18367	0.164466671336449	0.419073729847682	CTNNB1	1
GO:0050308	sugar-phosphatase activity	1/327	10/18367	0.164466671336449	0.419073729847682	PFKFB3	1
GO:0098505	G-rich strand telomeric DNA binding	1/327	10/18367	0.164466671336449	0.419073729847682	HNRNPA1	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2/327	42/18367	0.171634378158859	0.42060034117437	NDUFS5/NDUFA6	2
GO:0016504	peptidase activator activity	2/327	43/18367	0.178012335276794	0.42060034117437	FN1/FBLN1	2
GO:0030544	Hsp70 protein binding	2/327	43/18367	0.178012335276794	0.42060034117437	DNAJA1/SNCA	2
GO:0050136	NADH dehydrogenase (quinone) activity	2/327	43/18367	0.178012335276794	0.42060034117437	NDUFS5/NDUFA6	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/327	11/18367	0.179350334161147	0.42060034117437	BCL6	1
GO:0004143	diacylglycerol kinase activity	1/327	11/18367	0.179350334161147	0.42060034117437	DGKZ	1
GO:0004954	prostanoid receptor activity	1/327	11/18367	0.179350334161147	0.42060034117437	PTGER4	1
GO:0005536	glucose binding	1/327	11/18367	0.179350334161147	0.42060034117437	SLC2A3	1
GO:0008199	ferric iron binding	1/327	11/18367	0.179350334161147	0.42060034117437	FTH1	1
GO:0016273	arginine N-methyltransferase activity	1/327	11/18367	0.179350334161147	0.42060034117437	PRMT9	1
GO:0016274	protein-arginine N-methyltransferase activity	1/327	11/18367	0.179350334161147	0.42060034117437	PRMT9	1
GO:0019864	IgG binding	1/327	11/18367	0.179350334161147	0.42060034117437	FCGR3A	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/327	11/18367	0.179350334161147	0.42060034117437	TRIB1	1
GO:0043560	insulin receptor substrate binding	1/327	11/18367	0.179350334161147	0.42060034117437	GRB2	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/327	11/18367	0.179350334161147	0.42060034117437	PGK1	1
GO:0061665	SUMO ligase activity	1/327	11/18367	0.179350334161147	0.42060034117437	PIAS1	1
GO:0070513	death domain binding	1/327	11/18367	0.179350334161147	0.42060034117437	MCL1	1
GO:1990459	transferrin receptor binding	1/327	11/18367	0.179350334161147	0.42060034117437	CD81	1
GO:0051879	Hsp90 protein binding	2/327	44/18367	0.184426333776194	0.428349677338336	HIF1A/GBP1	2
GO:0003954	NADH dehydrogenase activity	2/327	45/18367	0.190873082467515	0.428349677338336	NDUFS5/NDUFA6	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	2/327	45/18367	0.190873082467515	0.428349677338336	NDUFS5/NDUFA6	2
GO:0051015	actin filament binding	6/327	217/18367	0.191311435377447	0.428349677338336	FRG1/MARCKSL1/TLN1/TPM3/MARCKS/COTL1	6
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/327	12/18367	0.193969665209812	0.428349677338336	CDKN1A	1
GO:0005165	neurotrophin receptor binding	1/327	12/18367	0.193969665209812	0.428349677338336	GRB2	1
GO:0017166	vinculin binding	1/327	12/18367	0.193969665209812	0.428349677338336	TLN1	1
GO:0035256	G protein-coupled glutamate receptor binding	1/327	12/18367	0.193969665209812	0.428349677338336	PRNP	1
GO:0035325	Toll-like receptor binding	1/327	12/18367	0.193969665209812	0.428349677338336	S100A8	1
GO:0043047	single-stranded telomeric DNA binding	1/327	12/18367	0.193969665209812	0.428349677338336	HNRNPA1	1
GO:0043422	protein kinase B binding	1/327	12/18367	0.193969665209812	0.428349677338336	SRSF5	1
GO:0061578	Lys63-specific deubiquitinase activity	1/327	12/18367	0.193969665209812	0.428349677338336	TNFAIP3	1
GO:0070410	co-SMAD binding	1/327	12/18367	0.193969665209812	0.428349677338336	TGIF1	1
GO:0089720	caspase binding	1/327	12/18367	0.193969665209812	0.428349677338336	RIPK2	1
GO:1901681	sulfur compound binding	7/327	265/18367	0.194959386796765	0.428748858930644	FN1/VEGFA/HBEGF/APOE/PF4/THBS1/AOC1	7
GO:0004864	protein phosphatase inhibitor activity	2/327	46/18367	0.197349395257028	0.430432837391872	PHACTR1/SET	2
GO:0061980	regulatory RNA binding	2/327	46/18367	0.197349395257028	0.430432837391872	HNRNPA1/YBX1	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/327	47/18367	0.203852188467205	0.440986366888239	DUSP2/DUSP1	2
GO:0019829	ATPase-coupled cation transmembrane transporter activity	2/327	47/18367	0.203852188467205	0.440986366888239	ATP1B3/ATP6V1B2	2
GO:0048306	calcium-dependent protein binding	3/327	88/18367	0.206788679100001	0.445520324890246	DDX5/S100A6/S100A8	3
GO:0072542	protein phosphatase activator activity	1/327	13/18367	0.208329344832607	0.447022480814905	PPP1R15A	1
GO:0019212	phosphatase inhibitor activity	2/327	49/18367	0.216925377872814	0.459107560590008	PHACTR1/SET	2
GO:0015399	primary active transmembrane transporter activity	5/327	181/18367	0.221425510109211	0.459107560590008	ATP1B3/COX7A2L/NDUFS5/ATP6V1B2/NDUFA6	5
GO:0005172	vascular endothelial growth factor receptor binding	1/327	14/18367	0.222433970758276	0.459107560590008	VEGFA	1
GO:0005344	oxygen carrier activity	1/327	14/18367	0.222433970758276	0.459107560590008	HBG1	1
GO:0036041	long-chain fatty acid binding	1/327	14/18367	0.222433970758276	0.459107560590008	S100A8	1
GO:0043023	ribosomal large subunit binding	1/327	14/18367	0.222433970758276	0.459107560590008	NPM1	1
GO:0044548	S100 protein binding	1/327	14/18367	0.222433970758276	0.459107560590008	S100A6	1
GO:0070411	I-SMAD binding	1/327	14/18367	0.222433970758276	0.459107560590008	CTNNB1	1
GO:0071837	HMG box domain binding	1/327	14/18367	0.222433970758276	0.459107560590008	JUN	1
GO:0015485	cholesterol binding	2/327	50/18367	0.223490095532494	0.459107560590008	VDAC2/CD81	2
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	2/327	50/18367	0.223490095532494	0.459107560590008	CDKN1A/CCNL1	2
GO:0043130	ubiquitin binding	3/327	92/18367	0.225378917018183	0.46120010046192	TNFAIP3/CXCR4/RNF19B	3
GO:0072341	modified amino acid binding	3/327	93/18367	0.230077100016697	0.465548964909154	TLN1/HMGB1/THBS1	3
GO:0020037	heme binding	4/327	139/18367	0.235573826649298	0.465548964909154	CYCS/PTGS2/HMOX1/HBG1	4
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/327	15/18367	0.236288059548231	0.465548964909154	PDE4B	1
GO:0004953	icosanoid receptor activity	1/327	15/18367	0.236288059548231	0.465548964909154	PTGER4	1
GO:0005041	low-density lipoprotein particle receptor activity	1/327	15/18367	0.236288059548231	0.465548964909154	OLR1	1
GO:0005161	platelet-derived growth factor receptor binding	1/327	15/18367	0.236288059548231	0.465548964909154	VEGFA	1
GO:0032794	GTPase activating protein binding	1/327	15/18367	0.236288059548231	0.465548964909154	TUBB	1
GO:0042809	vitamin D receptor binding	1/327	15/18367	0.236288059548231	0.465548964909154	MED13	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/327	15/18367	0.236288059548231	0.465548964909154	NCF2	1
GO:0098847	sequence-specific single stranded DNA binding	1/327	15/18367	0.236288059548231	0.465548964909154	HNRNPA1	1
GO:0004896	cytokine receptor activity	3/327	97/18367	0.249040744083238	0.474712922771719	CXCR4/CCRL2/IFNGR2	3
GO:0004698	calcium-dependent protein kinase C activity	1/327	16/18367	0.249896048025113	0.474712922771719	CCL3	1
GO:0005159	insulin-like growth factor receptor binding	1/327	16/18367	0.249896048025113	0.474712922771719	YWHAH	1
GO:0005523	tropomyosin binding	1/327	16/18367	0.249896048025113	0.474712922771719	S100A6	1
GO:0008191	metalloendopeptidase inhibitor activity	1/327	16/18367	0.249896048025113	0.474712922771719	TIMP3	1
GO:0016004	phospholipase activator activity	1/327	16/18367	0.249896048025113	0.474712922771719	CCL3	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/327	16/18367	0.249896048025113	0.474712922771719	AOC1	1
GO:0032183	SUMO binding	1/327	16/18367	0.249896048025113	0.474712922771719	SERBP1	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/327	16/18367	0.249896048025113	0.474712922771719	SOCS3	1
GO:0050700	CARD domain binding	1/327	16/18367	0.249896048025113	0.474712922771719	RIPK2	1
GO:0004722	protein serine/threonine phosphatase activity	3/327	98/18367	0.253819265621151	0.474862782045286	DUSP2/DUSP1/PPP3CA	3
GO:0005080	protein kinase C binding	2/327	55/18367	0.25648956658221	0.474862782045286	PLEK/MARCKS	2
GO:0030374	nuclear receptor coactivator activity	2/327	56/18367	0.263107567427723	0.474862782045286	ZMIZ1/MED13	2
GO:0003951	NAD+ kinase activity	1/327	17/18367	0.263262294676292	0.474862782045286	DGKZ	1
GO:0004697	protein kinase C activity	1/327	17/18367	0.263262294676292	0.474862782045286	CCL3	1
GO:0008308	voltage-gated anion channel activity	1/327	17/18367	0.263262294676292	0.474862782045286	VDAC2	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/327	17/18367	0.263262294676292	0.474862782045286	FTH1	1
GO:0017081	chloride channel regulator activity	1/327	17/18367	0.263262294676292	0.474862782045286	SGK1	1
GO:0030169	low-density lipoprotein particle binding	1/327	17/18367	0.263262294676292	0.474862782045286	THBS1	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	1/327	17/18367	0.263262294676292	0.474862782045286	ATP6V1B2	1
GO:0043395	heparan sulfate proteoglycan binding	1/327	17/18367	0.263262294676292	0.474862782045286	APOE	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1/327	17/18367	0.263262294676292	0.474862782045286	ATP6V1B2	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1/327	17/18367	0.263262294676292	0.474862782045286	ATP6V1B2	1
GO:0046965	retinoid X receptor binding	1/327	17/18367	0.263262294676292	0.474862782045286	NR4A2	1
GO:0005496	steroid binding	3/327	100/18367	0.26341444890814	0.474862782045286	GPR183/VDAC2/CD81	3
GO:0008528	G protein-coupled peptide receptor activity	4/327	147/18367	0.266616377896946	0.479005695882648	CXCR4/GPR84/CCRL2/FPR3	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	2/327	57/18367	0.269726297688832	0.48295587086176	PRDX3/PGK1	2
GO:0046906	tetrapyrrole binding	4/327	149/18367	0.274495123751163	0.486668680888216	CYCS/PTGS2/HMOX1/HBG1	4
GO:0030228	lipoprotein particle receptor activity	1/327	18/18367	0.276391081032741	0.486668680888216	OLR1	1
GO:0042834	peptidoglycan binding	1/327	18/18367	0.276391081032741	0.486668680888216	NLRP3	1
GO:0048038	quinone binding	1/327	18/18367	0.276391081032741	0.486668680888216	AOC1	1
GO:0060229	lipase activator activity	1/327	18/18367	0.276391081032741	0.486668680888216	CCL3	1
GO:0005516	calmodulin binding	5/327	201/18367	0.288263569564946	0.501051976805773	RGS1/DDX5/MARCKSL1/MARCKS/PPP3CA	5
GO:0003746	translation elongation factor activity	1/327	19/18367	0.28928661302371	0.501051976805773	EEF1A1	1
GO:0004129	cytochrome-c oxidase activity	1/327	19/18367	0.28928661302371	0.501051976805773	COX7A2L	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/327	19/18367	0.28928661302371	0.501051976805773	SNX3	1
GO:0030627	pre-mRNA 5'-splice site binding	1/327	19/18367	0.28928661302371	0.501051976805773	RNU11	1
GO:0001653	peptide receptor activity	4/327	153/18367	0.290364608386465	0.501280920015721	CXCR4/GPR84/CCRL2/FPR3	4
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/327	20/18367	0.301953022307624	0.509665929372741	HNRNPU	1
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	1/327	20/18367	0.301953022307624	0.509665929372741	ATP6V1B2	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/327	20/18367	0.301953022307624	0.509665929372741	AOC1	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/327	20/18367	0.301953022307624	0.509665929372741	COX7A2L	1
GO:0019211	phosphatase activator activity	1/327	20/18367	0.301953022307624	0.509665929372741	PPP1R15A	1
GO:0031681	G-protein beta-subunit binding	1/327	20/18367	0.301953022307624	0.509665929372741	GNG11	1
GO:0042288	MHC class I protein binding	1/327	20/18367	0.301953022307624	0.509665929372741	TUBB	1
GO:0001848	complement binding	1/327	21/18367	0.314394367579625	0.520715671303755	C5AR1	1
GO:0015662	P-type ion transporter activity	1/327	21/18367	0.314394367579625	0.520715671303755	ATP1B3	1
GO:0019200	carbohydrate kinase activity	1/327	21/18367	0.314394367579625	0.520715671303755	PFKFB3	1
GO:0051010	microtubule plus-end binding	1/327	21/18367	0.314394367579625	0.520715671303755	MAPRE1	1
GO:0140358	P-type transmembrane transporter activity	1/327	21/18367	0.314394367579625	0.520715671303755	ATP1B3	1
GO:0140416	transcription regulator inhibitor activity	1/327	21/18367	0.314394367579625	0.520715671303755	ID2	1
GO:0004843	thiol-dependent deubiquitinase	3/327	113/18367	0.326537159682743	0.53412917910906	TNFAIP3/OTUD1/JOSD1	3
GO:0033691	sialic acid binding	1/327	22/18367	0.326614635856169	0.53412917910906	FCN1	1
GO:0070034	telomerase RNA binding	1/327	22/18367	0.326614635856169	0.53412917910906	HNRNPU	1
GO:0120020	cholesterol transfer activity	1/327	22/18367	0.326614635856169	0.53412917910906	APOE	1
GO:0101005	deubiquitinase activity	3/327	114/18367	0.331414179293306	0.53412917910906	TNFAIP3/OTUD1/JOSD1	3
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/327	23/18367	0.338617743737064	0.53412917910906	PDE4B	1
GO:0005158	insulin receptor binding	1/327	23/18367	0.338617743737064	0.53412917910906	IRS2	1
GO:0008143	poly(A) binding	1/327	23/18367	0.338617743737064	0.53412917910906	HNRNPU	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/327	23/18367	0.338617743737064	0.53412917910906	CCL3	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/327	23/18367	0.338617743737064	0.53412917910906	PTGS2	1
GO:0017134	fibroblast growth factor binding	1/327	23/18367	0.338617743737064	0.53412917910906	THBS1	1
GO:0019865	immunoglobulin binding	1/327	23/18367	0.338617743737064	0.53412917910906	FCGR3A	1
GO:0030215	semaphorin receptor binding	1/327	23/18367	0.338617743737064	0.53412917910906	SEMA4D	1
GO:0030552	cAMP binding	1/327	23/18367	0.338617743737064	0.53412917910906	PDE4B	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/327	23/18367	0.338617743737064	0.53412917910906	TNFAIP3	1
GO:0120015	sterol transfer activity	1/327	23/18367	0.338617743737064	0.53412917910906	APOE	1
GO:0003684	damaged DNA binding	2/327	68/18367	0.342025889598653	0.537904218063163	HMGB2/HMGB1	2
GO:0005518	collagen binding	2/327	69/18367	0.348508239083179	0.541446050968066	FN1/THBS1	2
GO:0003707	steroid hormone receptor activity	1/327	24/18367	0.350407538645371	0.541446050968066	NR4A3	1
GO:0010857	calcium-dependent protein kinase activity	1/327	24/18367	0.350407538645371	0.541446050968066	CCL3	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/327	24/18367	0.350407538645371	0.541446050968066	PTGS2	1
GO:0050431	transforming growth factor beta binding	1/327	24/18367	0.350407538645371	0.541446050968066	THBS1	1
GO:0070840	dynein complex binding	1/327	24/18367	0.350407538645371	0.541446050968066	SNCA	1
GO:0030246	carbohydrate binding	6/327	271/18367	0.352789818208874	0.543542452472975	OLR1/CD69/SLC2A3/FCN1/HLA-DRA/HLA-DRB1	6
GO:0031491	nucleosome binding	2/327	71/18367	0.361407148105186	0.54972359319234	HMGN2/HMGN1	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/327	25/18367	0.361987800045522	0.54972359319234	PDE4B	1
GO:0005160	transforming growth factor beta receptor binding	1/327	25/18367	0.361987800045522	0.54972359319234	LRG1	1
GO:0008266	poly(U) RNA binding	1/327	25/18367	0.361987800045522	0.54972359319234	SSB	1
GO:0051019	mitogen-activated protein kinase binding	1/327	25/18367	0.361987800045522	0.54972359319234	DUSP1	1
GO:0000049	tRNA binding	2/327	72/18367	0.367821184842015	0.556986365617909	EEF1A1/SSB	2
GO:0005179	hormone activity	3/327	122/18367	0.370331202787214	0.559189565462175	METRNL/CSH1/RETN	3
GO:0038187	pattern recognition receptor activity	1/327	26/18367	0.373362240640066	0.560257930105036	FCN1	1
GO:0042974	retinoic acid receptor binding	1/327	26/18367	0.373362240640066	0.560257930105036	NR4A2	1
GO:0033293	monocarboxylic acid binding	2/327	73/18367	0.374210013692798	0.560257930105036	S100A8/APOC1	2
GO:0008139	nuclear localization sequence binding	1/327	27/18367	0.384534507545397	0.566559798253794	NFKBIA	1
GO:0030507	spectrin binding	1/327	27/18367	0.384534507545397	0.566559798253794	GBP1	1
GO:0043425	bHLH transcription factor binding	1/327	27/18367	0.384534507545397	0.566559798253794	BHLHE40	1
GO:0045499	chemorepellent activity	1/327	27/18367	0.384534507545397	0.566559798253794	SEMA4D	1
GO:0070006	metalloaminopeptidase activity	1/327	27/18367	0.384534507545397	0.566559798253794	LAP3	1
GO:0019783	ubiquitin-like protein-specific protease activity	3/327	125/18367	0.384833070512011	0.566559798253794	TNFAIP3/OTUD1/JOSD1	3
GO:0019003	GDP binding	2/327	75/18367	0.386907556707425	0.568036025082923	RAB5C/GBP1	2
GO:0008242	omega peptidase activity	3/327	126/18367	0.389650585836963	0.570482901915996	TNFAIP3/OTUD1/JOSD1	3
GO:0003785	actin monomer binding	1/327	28/18367	0.395508183446851	0.571169856203899	TMSB4X	1
GO:0043236	laminin binding	1/327	28/18367	0.395508183446851	0.571169856203899	THBS1	1
GO:0046875	ephrin receptor binding	1/327	28/18367	0.395508183446851	0.571169856203899	GRB2	1
GO:0050681	androgen receptor binding	1/327	28/18367	0.395508183446851	0.571169856203899	DDX5	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/327	28/18367	0.395508183446851	0.571169856203899	SNX3	1
GO:0032452	histone demethylase activity	1/327	29/18367	0.406286787733501	0.578849455641816	KDM6B	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/327	29/18367	0.406286787733501	0.578849455641816	PLEK	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/327	29/18367	0.406286787733501	0.578849455641816	SNX3	1
GO:0070717	poly-purine tract binding	1/327	29/18367	0.406286787733501	0.578849455641816	HNRNPU	1
GO:0140457	protein demethylase activity	1/327	29/18367	0.406286787733501	0.578849455641816	KDM6B	1
GO:0022829	wide pore channel activity	1/327	30/18367	0.416873777613049	0.590756957579989	VDAC2	1
GO:0046966	thyroid hormone receptor binding	1/327	30/18367	0.416873777613049	0.590756957579989	MED13	1
GO:0005164	tumor necrosis factor receptor binding	1/327	31/18367	0.427272549207123	0.600674936551127	TNF	1
GO:0043015	gamma-tubulin binding	1/327	31/18367	0.427272549207123	0.600674936551127	PDE4B	1
GO:0090482	vitamin transmembrane transporter activity	1/327	31/18367	0.427272549207123	0.600674936551127	SLC2A3	1
GO:0030332	cyclin binding	1/327	32/18367	0.437486438627349	0.606983802284019	CDKN1A	1
GO:0031624	ubiquitin conjugating enzyme binding	1/327	32/18367	0.437486438627349	0.606983802284019	RNF19B	1
GO:0048019	receptor antagonist activity	1/327	32/18367	0.437486438627349	0.606983802284019	IL1RN	1
GO:0050699	WW domain binding	1/327	32/18367	0.437486438627349	0.606983802284019	LITAF	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/327	32/18367	0.437486438627349	0.606983802284019	CHD1	1
GO:0001540	amyloid-beta binding	2/327	84/18367	0.442531597136931	0.612380539118991	PRNP/APOE	2
GO:0001530	lipopolysaccharide binding	1/327	33/18367	0.447518723032523	0.616064735603213	HMGB1	1
GO:0051427	hormone receptor binding	1/327	33/18367	0.447518723032523	0.616064735603213	CSH1	1
GO:0005543	phospholipid binding	9/327	466/18367	0.449632758115916	0.617371403630661	VDAC2/SNX3/SNCA/TLN1/ANXA5/APOE/HMGB1/THBS1/APOC1	9
GO:0030291	protein serine/threonine kinase inhibitor activity	1/327	34/18367	0.457372621667211	0.624761570834076	CDKN1A	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/327	34/18367	0.457372621667211	0.624761570834076	IRS2	1
GO:0019838	growth factor binding	3/327	141/18367	0.4604933762273	0.627407427764701	DUSP1/IL1RN/THBS1	3
GO:0008081	phosphoric diester hydrolase activity	2/327	89/18367	0.472213348196238	0.638451720775526	PDE4B/HMOX1	2
GO:0043178	alcohol binding	2/327	89/18367	0.472213348196238	0.638451720775526	VDAC2/CD81	2
GO:0051117	ATPase binding	2/327	89/18367	0.472213348196238	0.638451720775526	ATP1B3/PPP3CA	2
GO:0005484	SNAP receptor activity	1/327	36/18367	0.476557855136508	0.64105498279784	STX11	1
GO:0015248	sterol transporter activity	1/327	36/18367	0.476557855136508	0.64105498279784	APOE	1
GO:0015035	protein-disulfide reductase activity	1/327	37/18367	0.485895347983072	0.647046568922181	PGK1	1
GO:0030551	cyclic nucleotide binding	1/327	37/18367	0.485895347983072	0.647046568922181	PDE4B	1
GO:0043531	ADP binding	1/327	37/18367	0.485895347983072	0.647046568922181	PGK1	1
GO:0046915	transition metal ion transmembrane transporter activity	1/327	37/18367	0.485895347983072	0.647046568922181	SLC25A37	1
GO:0051213	dioxygenase activity	2/327	92/18367	0.489561361011537	0.650294539689511	KDM6B/PTGS2	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/327	38/18367	0.495066773035419	0.654327655134096	PPIF	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/327	38/18367	0.495066773035419	0.654327655134096	RNF19B	1
GO:0032451	demethylase activity	1/327	39/18367	0.504075074918633	0.662927517883065	KDM6B	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/327	39/18367	0.504075074918633	0.662927517883065	UFC1	1
GO:0003925	G protein activity	1/327	40/18367	0.512923146203094	0.669579476570542	RAB5C	1
GO:0004177	aminopeptidase activity	1/327	40/18367	0.512923146203094	0.669579476570542	LAP3	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/327	40/18367	0.512923146203094	0.669579476570542	HMOX1	1
GO:0016859	cis-trans isomerase activity	1/327	41/18367	0.521613828321912	0.677586590712288	PPIF	1
GO:0030331	estrogen receptor binding	1/327	41/18367	0.521613828321912	0.677586590712288	CTNNB1	1
GO:0015036	disulfide oxidoreductase activity	1/327	42/18367	0.530149912472231	0.685315740512884	PGK1	1
GO:0019894	kinesin binding	1/327	42/18367	0.530149912472231	0.685315740512884	SNCA	1
GO:0004674	protein serine/threonine kinase activity	7/327	386/18367	0.533658659853171	0.687766492687633	CCL3/PIM3/MAP3K8/SGK1/PIM1/STK17B/RIPK2	7
GO:0004180	carboxypeptidase activity	1/327	43/18367	0.538534140500694	0.687766492687633	LAP3	1
GO:0005246	calcium channel regulator activity	1/327	43/18367	0.538534140500694	0.687766492687633	SGK1	1
GO:0030547	signaling receptor inhibitor activity	1/327	43/18367	0.538534140500694	0.687766492687633	IL1RN	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/327	43/18367	0.538534140500694	0.687766492687633	SNX3	1
GO:0004725	protein tyrosine phosphatase activity	2/327	102/18367	0.544727707938544	0.694004050979395	DUSP2/DUSP1	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/327	44/18367	0.546769205773357	0.694934482157983	SGK1	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1/327	45/18367	0.554857754030307	0.703527774248955	RIPK2	1
GO:0140296	general transcription initiation factor binding	1/327	46/18367	0.562802384225269	0.711898003912632	HNRNPU	1
GO:0035254	glutamate receptor binding	1/327	47/18367	0.570605649350444	0.719760569319927	PRNP	1
GO:0019787	ubiquitin-like protein transferase activity	8/327	458/18367	0.571734339025829	0.719760569319927	TNFAIP3/BIRC3/UFC1/TRIM22/SUMO2/RNF19B/HERC5/PIAS1	8
GO:0015026	coreceptor activity	1/327	48/18367	0.578270057246864	0.723774709135734	CXCR4	1
GO:0120013	lipid transfer activity	1/327	48/18367	0.578270057246864	0.723774709135734	APOE	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2/327	109/18367	0.580804998014761	0.723774709135734	ATP1B3/ATP6V1B2	2
GO:0000149	SNARE binding	2/327	110/18367	0.585784576297236	0.723774709135734	STX11/SNCA	2
GO:0047485	protein N-terminus binding	2/327	110/18367	0.585784576297236	0.723774709135734	NPM1/SNCA	2
GO:0016763	pentosyltransferase activity	1/327	49/18367	0.58579807140049	0.723774709135734	TYMP	1
GO:0032813	tumor necrosis factor receptor superfamily binding	1/327	49/18367	0.58579807140049	0.723774709135734	TNF	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3/327	170/18367	0.585847830602321	0.723774709135734	KDM6B/PTGS2/HMOX1	3
GO:0000993	RNA polymerase II complex binding	1/327	50/18367	0.593192111724327	0.728490019412932	HNRNPU	1
GO:0005048	signal sequence binding	1/327	50/18367	0.593192111724327	0.728490019412932	NFKBIA	1
GO:0005201	extracellular matrix structural constituent	3/327	172/18367	0.593788091295069	0.728490019412932	FN1/FBLN1/THBS1	3
GO:0004721	phosphoprotein phosphatase activity	3/327	174/18367	0.601629384082758	0.736405481671737	DUSP2/DUSP1/PPP3CA	3
GO:0031593	polyubiquitin modification-dependent protein binding	1/327	52/18367	0.607587737266513	0.740748929769039	TNFAIP3	1
GO:0030674	protein-macromolecule adaptor activity	5/327	296/18367	0.609106278225835	0.740748929769039	KLF4/ATP1B3/STX11/GRB2/TRIM22	5
GO:0031406	carboxylic acid binding	3/327	176/18367	0.609370817696794	0.740748929769039	FCN1/S100A8/APOC1	3
GO:0017069	snRNA binding	1/327	53/18367	0.614593951294023	0.745388545047672	HNRNPU	1
GO:0005544	calcium-dependent phospholipid binding	1/327	54/18367	0.62147545058019	0.747028110233171	ANXA5	1
GO:0015459	potassium channel regulator activity	1/327	54/18367	0.62147545058019	0.747028110233171	SGK1	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/327	54/18367	0.62147545058019	0.747028110233171	KDM6B	1
GO:0106310	protein serine kinase activity	6/327	360/18367	0.621583767194016	0.747028110233171	PIM3/MAP3K8/SGK1/PIM1/STK17B/RIPK2	6
GO:0051287	NAD binding	1/327	56/18367	0.634873118995719	0.761273196985816	LDHA	1
GO:0042578	phosphoric ester hydrolase activity	6/327	366/18367	0.637479812939652	0.762673365367981	DUSP2/DUSP1/PDE4B/HMOX1/PFKFB3/PPP3CA	6
GO:0043175	RNA polymerase core enzyme binding	1/327	57/18367	0.641393597947627	0.765627493045591	HNRNPU	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/327	124/18367	0.650910045050003	0.775241177250565	LDHA/DCXR	2
GO:0008234	cysteine-type peptidase activity	3/327	190/18367	0.660712608042882	0.785151753952304	TNFAIP3/OTUD1/JOSD1	3
GO:0061659	ubiquitin-like protein ligase activity	5/327	316/18367	0.66608247057786	0.788298105500839	BIRC3/TRIM22/RNF19B/HERC5/PIAS1	5
GO:0043621	protein self-association	1/327	61/18367	0.666335002385615	0.788298105500839	TNFAIP3	1
GO:0015078	proton transmembrane transporter activity	2/327	130/18367	0.676229689527043	0.798222127949516	COX7A2L/ATP6V1B2	2
GO:0002039	p53 binding	1/327	66/18367	0.695093483219634	0.81811955941955	HIF1A	1
GO:0043177	organic acid binding	2/327	135/18367	0.69617343641173	0.81811955941955	HBG1/S100A8	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	2/327	136/18367	0.70003836759713	0.819618108145279	LDHA/DCXR	2
GO:0097110	scaffold protein binding	1/327	67/18367	0.700541515075116	0.819618108145279	TREM1	1
GO:0008080	N-acetyltransferase activity	1/327	68/18367	0.705892494559839	0.82405952008087	SAT1	1
GO:0099106	ion channel regulator activity	2/327	139/18367	0.711389370886035	0.828651355098019	SGK1/YWHAH	2
GO:0001098	basal transcription machinery binding	1/327	70/18367	0.716310160703149	0.830731696220282	HNRNPU	1
GO:0001099	basal RNA polymerase II transcription machinery binding	1/327	70/18367	0.716310160703149	0.830731696220282	HNRNPU	1
GO:0005096	GTPase activator activity	7/327	462/18367	0.718924746511705	0.831943483954593	JUN/TAGAP/RASGEF1B/RGS1/SMAP2/RGS10/NCKAP1L	7
GO:0048029	monosaccharide binding	1/327	71/18367	0.721380203740262	0.832966248327536	SLC2A3	1
GO:0016791	phosphatase activity	4/327	275/18367	0.724644789355036	0.833270024594907	DUSP2/DUSP1/PFKFB3/PPP3CA	4
GO:0003678	DNA helicase activity	1/327	72/18367	0.726359908231787	0.833270024594907	CHD1	1
GO:0008235	metalloexopeptidase activity	1/327	72/18367	0.726359908231787	0.833270024594907	LAP3	1
GO:0035064	methylated histone binding	1/327	73/18367	0.731250878989273	0.833468743794225	CHD1	1
GO:0140034	methylation-dependent protein binding	1/327	73/18367	0.731250878989273	0.833468743794225	CHD1	1
GO:0140104	molecular carrier activity	1/327	73/18367	0.731250878989273	0.833468743794225	HBG1	1
GO:0016247	channel regulator activity	2/327	145/18367	0.733015254834182	0.833686877815701	SGK1/YWHAH	2
GO:0017022	myosin binding	1/327	74/18367	0.736054692401895	0.835351149835127	CXCR4	1
GO:0003724	RNA helicase activity	1/327	77/18367	0.749958536603951	0.847501118123868	DDX5	1
GO:0038024	cargo receptor activity	1/327	77/18367	0.749958536603951	0.847501118123868	OLR1	1
GO:0005506	iron ion binding	2/327	151/18367	0.753251095945226	0.84893277013751	SNCA/FTH1	2
GO:0030971	receptor tyrosine kinase binding	1/327	78/18367	0.754428933461825	0.84893277013751	TOB1	1
GO:0000287	magnesium ion binding	3/327	221/18367	0.756547598118358	0.849513192802393	MAP3K8/PPA1/SNCA	3
GO:0008186	ATP-dependent activity, acting on RNA	1/327	79/18367	0.758819645844021	0.850263028112751	DDX5	1
GO:0051020	GTPase binding	4/327	291/18367	0.764260345553309	0.854552707053278	BRK1/NCF2/YBX3/YBX1	4
GO:0004386	helicase activity	2/327	156/18367	0.769093714800199	0.854876302814023	DDX5/CHD1	2
GO:0030695	GTPase regulator activity	7/327	488/18367	0.769388672532621	0.854876302814023	JUN/TAGAP/RASGEF1B/RGS1/SMAP2/RGS10/NCKAP1L	7
GO:0060589	nucleoside-triphosphatase regulator activity	7/327	488/18367	0.769388672532621	0.854876302814023	JUN/TAGAP/RASGEF1B/RGS1/SMAP2/RGS10/NCKAP1L	7
GO:0140030	modification-dependent protein binding	2/327	160/18367	0.781124710599573	0.866100620539275	TNFAIP3/CHD1	2
GO:0060090	molecular adaptor activity	5/327	369/18367	0.789334791270965	0.873376700153677	KLF4/ATP1B3/STX11/GRB2/TRIM22	5
GO:0005253	anion channel activity	1/327	87/18367	0.791241475827591	0.873662462892965	VDAC2	1
GO:0061630	ubiquitin protein ligase activity	4/327	304/18367	0.793074292570938	0.873865644620785	BIRC3/TRIM22/RNF19B/HERC5	4
GO:0008276	protein methyltransferase activity	1/327	88/18367	0.794975832359559	0.874143550104909	PRMT9	1
GO:0016407	acetyltransferase activity	1/327	91/18367	0.805784011697101	0.884193636023734	SAT1	1
GO:0016410	N-acyltransferase activity	1/327	94/18367	0.816024070917199	0.893580077657263	SAT1	1
GO:0008170	N-methyltransferase activity	1/327	97/18367	0.825725785848747	0.902339518556363	PRMT9	1
GO:0004867	serine-type endopeptidase inhibitor activity	1/327	98/18367	0.828844979501044	0.903884442665747	SERPINB9	1
GO:0004497	monooxygenase activity	1/327	102/18367	0.840774966422505	0.914359020742013	HMOX1	1
GO:0031267	small GTPase binding	3/327	259/18367	0.842955329501201	0.914359020742013	BRK1/NCF2/YBX3	3
GO:0008238	exopeptidase activity	1/327	103/18367	0.843625587061971	0.914359020742013	LAP3	1
GO:0004620	phospholipase activity	1/327	104/18367	0.846425326058397	0.915521271042756	HMOX1	1
GO:1990782	protein tyrosine kinase binding	1/327	105/18367	0.849175088878246	0.916624841355337	TOB1	1
GO:0022804	active transmembrane transporter activity	5/327	406/18367	0.85217078087838	0.917988849320207	ATP1B3/COX7A2L/NDUFS5/ATP6V1B2/NDUFA6	5
GO:1902936	phosphatidylinositol bisphosphate binding	1/327	107/18367	0.85452822781537	0.918661177975955	SNX3	1
GO:0022853	active ion transmembrane transporter activity	3/327	267/18367	0.857343329642582	0.919821790912082	ATP1B3/COX7A2L/ATP6V1B2	3
GO:0008094	ATP-dependent activity, acting on DNA	1/327	111/18367	0.864672883460644	0.925811370169983	CHD1	1
GO:0004842	ubiquitin-protein transferase activity	5/327	433/18367	0.887521277964472	0.948359430083004	TNFAIP3/BIRC3/TRIM22/RNF19B/HERC5	5
GO:0004714	transmembrane receptor protein tyrosine kinase activity	1/327	124/18367	0.89301899045858	0.952314013969915	RIPK2	1
GO:0016298	lipase activity	1/327	129/18367	0.902270354307181	0.960184332639161	HMOX1	1
GO:0017124	SH3 domain binding	1/327	130/18367	0.904022607522531	0.960184332639161	GRB2	1
GO:0005085	guanyl-nucleotide exchange factor activity	2/327	223/18367	0.909539075256125	0.964111419771493	TAGAP/RASGEF1B	2
GO:0004713	protein tyrosine kinase activity	1/327	136/18367	0.913897541911708	0.966797798828753	RIPK2	1
GO:0019199	transmembrane receptor protein kinase activity	1/327	143/18367	0.924145131825043	0.975691075432814	RIPK2	1
GO:0015081	sodium ion transmembrane transporter activity	1/327	152/18367	0.935553911975285	0.982704616386506	ATP1B3	1
GO:0015103	inorganic anion transmembrane transporter activity	1/327	152/18367	0.935553911975285	0.982704616386506	VDAC2	1
GO:0005319	lipid transporter activity	1/327	154/18367	0.937847107401351	0.982704616386506	APOE	1
GO:0015079	potassium ion transmembrane transporter activity	1/327	155/18367	0.938963013395957	0.982704616386506	ATP1B3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/327	156/18367	0.940058944354639	0.982704616386506	PRMT9	1
GO:0016853	isomerase activity	1/327	158/18367	0.942192300748018	0.982995904323719	PPIF	1
GO:0035091	phosphatidylinositol binding	2/327	271/18367	0.955628432772934	0.99185120010504	SNX3/TLN1	2
GO:1901981	phosphatidylinositol phosphate binding	1/327	173/18367	0.955955692643188	0.99185120010504	SNX3	1
GO:0016887	ATP hydrolysis activity	2/327	272/18367	0.956294270289953	0.99185120010504	DDX5/CHD1	2
GO:0008514	organic anion transmembrane transporter activity	1/327	185/18367	0.964572353440495	0.997982781364931	SLC2A3	1
GO:0008237	metallopeptidase activity	1/327	190/18367	0.967645929046488	0.997982781364931	LAP3	1
GO:0016829	lyase activity	1/327	196/18367	0.970985275834493	0.997982781364931	HMGB1	1
GO:0016758	hexosyltransferase activity	1/327	197/18367	0.9715074163222	0.997982781364931	TYMP	1
GO:0005244	voltage-gated ion channel activity	1/327	201/18367	0.973503958425791	0.997982781364931	VDAC2	1
GO:0022832	voltage-gated channel activity	1/327	201/18367	0.973503958425791	0.997982781364931	VDAC2	1
GO:0008509	anion transmembrane transporter activity	2/327	314/18367	0.977040065071234	0.999154776834748	VDAC2/SLC2A3	2
GO:0008168	methyltransferase activity	1/327	214/18367	0.979078522959639	0.999154776834748	PRMT9	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	1/327	222/18367	0.981910606470453	0.999154776834748	SAT1	1
GO:0016741	transferase activity, transferring one-carbon groups	1/327	225/18367	0.982871133083089	0.999154776834748	PRMT9	1
GO:0140097	catalytic activity, acting on DNA	1/327	229/18367	0.984073195297619	0.999154776834748	CHD1	1
GO:0016746	acyltransferase activity	1/327	250/18367	0.989132909172887	0.999842594743037	SAT1	1
GO:0016757	glycosyltransferase activity	1/327	270/18367	0.992452158138605	0.999842594743037	TYMP	1
GO:0046873	metal ion transmembrane transporter activity	2/327	430/18367	0.996381015482131	0.999842594743037	ATP1B3/SLC25A37	2
GO:0022836	gated channel activity	1/327	340/18367	0.997899065844123	0.999842594743037	VDAC2	1
GO:0140098	catalytic activity, acting on RNA	1/327	386/18367	0.999095846528927	0.999842594743037	DDX5	1
GO:0005216	ion channel activity	1/327	432/18367	0.999611737663926	0.999842594743037	VDAC2	1
GO:0015267	channel activity	1/327	480/18367	0.999839663563138	0.999842594743037	VDAC2	1
GO:0022803	passive transmembrane transporter activity	1/327	481/18367	0.999842594743037	0.999842594743037	VDAC2	1