ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0001618	virus receptor activity	13/428	76/18367	2.00777765302449e-08	7.8324198578216e-06	ITGB1/CD46/EGFR/HSPA1A/DAG1/DPP4/CD55/SLC1A5/TFRC/ITGAV/CD81/ITGB5/HSPA1B	13
GO:0140272	exogenous protein binding	13/428	77/18367	2.36511073278218e-08	7.8324198578216e-06	ITGB1/CD46/EGFR/HSPA1A/DAG1/DPP4/CD55/SLC1A5/TFRC/ITGAV/CD81/ITGB5/HSPA1B	13
GO:0019838	growth factor binding	17/428	141/18367	3.2276455458056e-08	7.8324198578216e-06	HTRA4/ITGA6/LIFR/EGFR/NRP2/IGFBP3/LRP2/NRP1/DUSP1/HAP1/ITGB4/ITGAV/COL4A1/IL6ST/GLG1/CRIM1/SDCBP	17
GO:0005178	integrin binding	17/428	144/18367	4.42612325956469e-08	8.05554433240774e-06	FBN1/ITGB1/ITGB8/EGFR/LAMA5/LAMB1/UTRN/P4HB/ITGB4/DST/SEMA7A/ITGAV/CD81/ITGB5/FN1/PLPP3/PPIA	17
GO:0097718	disordered domain specific binding	9/428	36/18367	1.00387385550506e-07	1.46164033361536e-05	GAPDH/HSPA1A/GJA1/CALM1/GJA5/HSP90AB1/CLTC/EZR/FN1	9
GO:0045296	cadherin binding	24/428	332/18367	1.04821532616832e-06	0.000127183459575089	LDHA/ITGB1/CD46/EIF4H/ITGA6/ANXA1/EGFR/HSPA1A/RPL24/FLNB/EFHD2/ALDOA/HSP90AB1/CDH1/EZR/P2RX4/RPL23A/RAB1A/EPS8L1/ENO1/PRDX1/PKM/PFN1/RPL6	24
GO:0005520	insulin-like growth factor binding	7/428	29/18367	3.55790738251667e-06	0.000370022367781734	HTRA4/ITGA6/IGFBP3/LRP2/ITGB4/ITGAV/CRIM1	7
GO:0017154	semaphorin receptor activity	5/428	12/18367	4.6448369906486e-06	0.000422680166149022	MET/NRP2/NRP1/PLXNB1/PLXNB2	5
GO:0031994	insulin-like growth factor I binding	5/428	13/18367	7.40348904037697e-06	0.000598860002377159	ITGA6/IGFBP3/LRP2/ITGB4/ITGAV	5
GO:0050840	extracellular matrix binding	8/428	56/18367	4.34288625650439e-05	0.00316162119473519	ITGB1/ITGA6/DAG1/ADGRG1/BCAM/ITGAV/TINAGL1/SPARC	8
GO:0002020	protease binding	12/428	135/18367	7.6730360927169e-05	0.00507815479590719	SERPINB9/ITGB1/ADAMTSL4/PSAP/DPP4/UBC/CLTC/ITGAV/CST3/FN1/GSK3B/LRP1	12
GO:0005539	glycosaminoglycan binding	16/428	230/18367	0.000103882452163608	0.00621198281737855	FBN1/FSTL1/GNS/NRP2/NRP1/BMP7/GREM2/ADGRG1/PTPRF/EXTL2/APLP2/FN1/PGF/PPIA/CCDC80/APP	16
GO:0003779	actin binding	24/428	440/18367	0.000110928264596045	0.00621198281737855	ITGB1/SCIN/CFL1/EGFR/TMSB10/DAG1/FLNB/GAS2L3/UTRN/ALDOA/ADD3/P4HB/SLC6A4/DST/PHACTR2/EZR/DIAPH2/SORBS1/MYO5B/EPS8L1/RAI14/TMSB4X/SYNE2/PFN1	24
GO:0051082	unfolded protein binding	11/428	122/18367	0.000133577362607014	0.00692256990333812	NPM1/HSPA1A/NACA/SIL1/LMAN1/DNAJA1/HSP90AB1/PTGES3/PPIA/HSPA1B/ERO1B	11
GO:0008201	heparin binding	13/428	166/18367	0.000142635368887461	0.00692256990333812	FBN1/FSTL1/NRP2/NRP1/BMP7/GREM2/ADGRG1/PTPRF/APLP2/FN1/PGF/CCDC80/APP	13
GO:0030215	semaphorin receptor binding	5/428	23/18367	0.000159663879753391	0.00726470652877931	SEMA6D/PLXNB1/SEMA7A/SEMA3F/SEMA4B	5
GO:1901681	sulfur compound binding	17/428	265/18367	0.000170490675849062	0.00730101247165395	FBN1/FSTL1/NRP2/NRP1/BMP7/GREM2/ADGRG1/PTPRF/APLP2/FN1/GSTM3/PGF/PPIA/CCDC80/APP/HADHA/LRP1	17
GO:0005201	extracellular matrix structural constituent	13/428	172/18367	0.000203069282471469	0.00821302431329054	FBN1/FBN2/COL21A1/TFPI2/LAMC1/COL4A2/EFEMP1/LAMA5/LAMB1/TINAGL1/FN1/COL4A1/SPARC	13
GO:0050998	nitric-oxide synthase binding	4/428	15/18367	0.00032363721588405	0.0124004154296625	ACTB/CALM1/SLC6A4/ATP2B4	4
GO:0045499	chemorepellent activity	5/428	27/18367	0.000354773026591604	0.0129137381679344	SEMA6D/DPP4/SEMA7A/SEMA3F/SEMA4B	5
GO:0001968	fibronectin binding	5/428	28/18367	0.000423704403490692	0.0140207638973284	ITGB1/IGFBP3/SDC4/ITGAV/CCDC80	5
GO:0043236	laminin binding	5/428	28/18367	0.000423704403490692	0.0140207638973284	ITGB1/ITGA6/DAG1/BCAM/TINAGL1	5
GO:0004867	serine-type endopeptidase inhibitor activity	9/428	98/18367	0.000469883362056238	0.0148728298946496	SERPINB9/SPINT1/ITIH5/TFPI/TFPI2/SERPINF1/APLP2/APP/CRIM1	9
GO:0061134	peptidase regulator activity	14/428	230/18367	0.00104539318587144	0.0314520503905662	SERPINB9/GAPDH/SPINT1/ITIH5/TFPI/TFPI2/CTSC/SERPINF1/BIRC6/APLP2/CST3/FN1/APP/CRIM1	14
GO:0004866	endopeptidase inhibitor activity	12/428	180/18367	0.00108008414802769	0.0314520503905662	SERPINB9/GAPDH/SPINT1/ITIH5/TFPI/TFPI2/SERPINF1/BIRC6/APLP2/CST3/APP/CRIM1	12
GO:0008239	dipeptidyl-peptidase activity	3/428	10/18367	0.00133466448648936	0.0359865091171946	DPP7/DPP4/CTSC	3
GO:0030957	Tat protein binding	3/428	10/18367	0.00133466448648936	0.0359865091171946	NPM1/ACTB/DNAJA1	3
GO:0030414	peptidase inhibitor activity	12/428	187/18367	0.00149798428213148	0.0382650507440582	SERPINB9/GAPDH/SPINT1/ITIH5/TFPI/TFPI2/SERPINF1/BIRC6/APLP2/CST3/APP/CRIM1	12
GO:0072349	modified amino acid transmembrane transporter activity	4/428	22/18367	0.0015242946038155	0.0382650507440582	SLC6A8/GJA1/SLC16A12/SLC5A6	4
GO:0097493	structural molecule activity conferring elasticity	3/428	11/18367	0.00180356627818065	0.0437665416838503	FBN1/FBN2/LAMC1	3
GO:0051287	NAD binding	6/428	56/18367	0.00187574423795412	0.0440497356526001	LDHA/GAPDH/HPGD/GPD1L/HADHA/ALDH1A3	6
GO:0015293	symporter activity	10/428	144/18367	0.00203921922428672	0.0449847175395333	SLC6A8/SLC13A4/SLC16A12/SLC16A4/SLC6A4/SLC1A5/SLC22A18/SLC5A6/SLC17A5/SLC5A3	10
GO:0061135	endopeptidase regulator activity	12/428	194/18367	0.00204110369402651	0.0449847175395333	SERPINB9/GAPDH/SPINT1/ITIH5/TFPI/TFPI2/SERPINF1/BIRC6/APLP2/CST3/APP/CRIM1	12
GO:0038024	cargo receptor activity	7/428	77/18367	0.00210093461036282	0.0449847175395333	OLR1/COLEC12/LRP2/LGALS3BP/TFRC/ABCA1/LRP1	7
GO:0043021	ribonucleoprotein complex binding	10/428	149/18367	0.0026188355963344	0.0544717804037555	EIF4H/EIF1/NPM1/SECISBP2L/RPN2/EIF4A3/NEAT1/CPEB4/CCDC47/EIF5A	10
GO:0072542	protein phosphatase activator activity	3/428	13/18367	0.00301964382217473	0.0610639084039778	IGFBP3/CALM1/PPP1R15A	3
GO:0016853	isomerase activity	10/428	158/18367	0.00398937043098491	0.0764969770568903	TPI1/MIF/CYP2J2/ISYNA1/P4HB/PTGES3/TOP1/PPIA/ERO1B/FKBP14	10
GO:0044325	transmembrane transporter binding	9/428	133/18367	0.00399297407714537	0.0764969770568903	TCAF1/CALM1/HAP1/AKAP9/HSP90AB1/GPD1L/ITPR2/HERPUD1/SLC5A3	9
GO:0003727	single-stranded RNA binding	7/428	87/18367	0.00418919315422911	0.0779542214138327	EIF4H/HNRNPA1/MSI2/ANXA1/CBX4/EIF4A3/HNRNPC	7
GO:0015291	secondary active transmembrane transporter activity	13/428	240/18367	0.00428319897878201	0.0779542214138327	SLC26A2/SLC6A8/SLC13A4/SLC16A12/SLC35D1/SLC16A4/SLC6A4/SLC1A5/SLC22A18/ANKH/SLC5A6/SLC17A5/SLC5A3	13
GO:0016757	glycosyltransferase activity	14/428	270/18367	0.0045529469283493	0.0788220157709199	GALNT11/PNP/UPP1/AGL/RPN2/C1GALT1/B4GALT1/CHPF/EXTL2/TMTC3/GCNT4/UMPS/B3GNT2/HEXB	14
GO:0005041	low-density lipoprotein particle receptor activity	3/428	15/18367	0.00464064921824015	0.0788220157709199	OLR1/LRP2/LRP1	3
GO:0097110	scaffold protein binding	6/428	67/18367	0.00465569598646917	0.0788220157709199	DYNLL1/KRT8/PSAP/ITPR2/ATP2B4/IL6ST	6
GO:0015026	coreceptor activity	5/428	48/18367	0.00504498612467773	0.0834715886083042	ITGB1/NRP1/LRP5/ITGAV/LRP1	5
GO:0019955	cytokine binding	9/428	139/18367	0.00532674648720547	0.0861749209485685	ITGB1/CSF3R/LIFR/NRP2/NRP1/GREM2/ITGAV/CSF2RA/IL6ST	9
GO:0070403	NAD+ binding	3/428	16/18367	0.00561381174296482	0.0888446728017041	HPGD/HADHA/ALDH1A3	3
GO:0004601	peroxidase activity	5/428	51/18367	0.00653960986074247	0.0956426389829926	GPX3/PRDX4/GSTK1/GPX8/PRDX1	5
GO:0016860	intramolecular oxidoreductase activity	5/428	51/18367	0.00653960986074247	0.0956426389829926	TPI1/MIF/P4HB/PTGES3/ERO1B	5
GO:0051018	protein kinase A binding	5/428	51/18367	0.00653960986074247	0.0956426389829926	AKAP9/DACT2/EZR/GSK3B/RPS3	5
GO:0016758	hexosyltransferase activity	11/428	197/18367	0.00663609692715159	0.0956426389829926	GALNT11/AGL/RPN2/C1GALT1/B4GALT1/CHPF/EXTL2/TMTC3/GCNT4/B3GNT2/HEXB	11
GO:0043024	ribosomal small subunit binding	3/428	17/18367	0.00670023981886349	0.0956426389829926	EIF4H/EIF1/NPM1	3
GO:1901682	sulfur compound transmembrane transporter activity	5/428	52/18367	0.00710003978380283	0.0970297290448276	SLC26A2/GJA1/SLC13A4/SLC19A3/SLC5A6	5
GO:0008509	anion transmembrane transporter activity	15/428	314/18367	0.0071082622245537	0.0970297290448276	SLC26A2/SLC6A8/LRRC8D/GJA1/SLC35B4/SLC13A4/ANO6/CLIC3/SLC16A12/SLC35D1/SLC6A4/SLC1A5/SLC38A9/ANKH/SLC5A6	15
GO:0022804	active transmembrane transporter activity	18/428	406/18367	0.00719726012145699	0.0970297290448276	SLC26A2/SLC6A8/ATP2B1/SLC13A4/SLC16A12/SLC35D1/SLC16A4/SLC6A4/SLC1A5/ATP2B4/SLC22A18/ABCA1/ANKH/COX7A2L/SLC5A6/COX6A1/SLC17A5/SLC5A3	18
GO:0044389	ubiquitin-like protein ligase binding	15/428	316/18367	0.00751596523630358	0.0994840489459819	TPI1/CEBPB/EGFR/HSPA1A/ACTG1/UBC/DNAJA1/HSP90AB1/MID1/SLC22A18/USP25/UBE2B/GSK3B/HSPA1B/UBASH3B	15
GO:0030228	lipoprotein particle receptor activity	3/428	18/18367	0.00790300746801234	0.10273909708416	OLR1/LRP2/LRP1	3
GO:0051020	GTPase binding	14/428	291/18367	0.00861482213209164	0.110027903722153	TNPO1/SH3BP4/YIPF1/SOD1/DIAPH2/MYO5B/CHML/ABCA1/C9orf72/ENO1/RABGAP1L/RASA1/PFN1/NUTF2	14
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/428	55/18367	0.00898107261544223	0.112727945931758	GPX3/PRDX4/GSTK1/GPX8/PRDX1	5
GO:0043394	proteoglycan binding	4/428	36/18367	0.00950234640707795	0.117249291260216	PTPRF/FN1/SDCBP/LRP1	4
GO:0031625	ubiquitin protein ligase binding	14/428	297/18367	0.0101900338272684	0.122226825642189	TPI1/EGFR/HSPA1A/ACTG1/UBC/DNAJA1/HSP90AB1/MID1/SLC22A18/USP25/UBE2B/GSK3B/HSPA1B/UBASH3B	14
GO:0003735	structural constituent of ribosome	10/428	182/18367	0.0104788774425254	0.122226825642189	RPL24/RPL36A/RPL9/RPL3/RPL23A/RPS10/RPL6/RPL4/RPS3/RPL27A	10
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	3/428	20/18367	0.0106678370971387	0.122226825642189	SGMS2/CHPT1/CDS1	3
GO:0019211	phosphatase activator activity	3/428	20/18367	0.0106678370971387	0.122226825642189	IGFBP3/CALM1/PPP1R15A	3
GO:0031072	heat shock protein binding	8/428	129/18367	0.0107452154410716	0.122226825642189	HSPA1A/DNAJA1/HSP90AB1/NR3C1/PTGES3/DNAJC8/HSPA1B/RPS3	8
GO:0098631	cell adhesion mediator activity	5/428	59/18367	0.0119883707988914	0.134269752947584	ITGB1/DSC2/ANXA1/CD47/BCAM	5
GO:0051015	actin filament binding	11/428	217/18367	0.0131276529296231	0.144801989890388	SCIN/CFL1/EGFR/FLNB/GAS2L3/UTRN/ADD3/SLC6A4/EZR/MYO5B/SYNE2	11
GO:0044183	protein folding chaperone	4/428	40/18367	0.0137106515331668	0.148975437554409	HSPA1A/HSP90AB1/HSPA1B/CCDC47	4
GO:0004602	glutathione peroxidase activity	3/428	22/18367	0.0139251122547973	0.149080613551359	GPX3/GSTK1/GPX8	3
GO:0008013	beta-catenin binding	6/428	85/18367	0.0144176418098226	0.152116568660157	KANK1/GJA1/DACT2/CDH1/TBL1X/GSK3B	6
GO:0016209	antioxidant activity	6/428	86/18367	0.0152042965981376	0.158124684620631	GPX3/PRDX4/GSTK1/SOD1/GPX8/PRDX1	6
GO:0008307	structural constituent of muscle	4/428	42/18367	0.0161952742813677	0.166058586997686	KRT19/DAG1/ASPH/MYL6	4
GO:0045182	translation regulator activity	8/428	140/18367	0.0169255645337619	0.171136263619148	EIF4H/EIF1/EEF1A1/IGF2BP3/EIF4A3/NEURL1/CPEB4/EIF5A	8
GO:0019888	protein phosphatase regulator activity	6/428	89/18367	0.0177418774806447	0.176932695971361	IGFBP3/CALM1/PPP1R15A/PHACTR2/RCAN1/PPP1R14B	6
GO:0031267	small GTPase binding	12/428	259/18367	0.0187877782887652	0.183893202068441	TNPO1/SH3BP4/YIPF1/SOD1/DIAPH2/MYO5B/CHML/ABCA1/C9orf72/RABGAP1L/PFN1/NUTF2	12
GO:0008375	acetylglucosaminyltransferase activity	4/428	44/18367	0.018945041421886	0.183893202068441	EXTL2/GCNT4/B3GNT2/HEXB	4
GO:0048156	tau protein binding	4/428	45/18367	0.0204216238123123	0.195617659675833	LGMN/ACTB/HSP90AB1/GSK3B	4
GO:0001664	G protein-coupled receptor binding	13/428	295/18367	0.0214510623342436	0.196017359338085	WLS/ADRB1/HSPA1A/CALM1/DNAJA1/ITGB4/RNF43/NPB/APELA/GNAQ/HSPA1B/ARRDC3/SDCBP	13
GO:0008330	protein tyrosine/threonine phosphatase activity	2/428	10/18367	0.0215403691580313	0.196017359338085	DUSP1/DUSP5	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/428	10/18367	0.0215403691580313	0.196017359338085	SLC35B4/SLC35D1	2
GO:0016783	sulfurtransferase activity	2/428	10/18367	0.0215403691580313	0.196017359338085	MOCS2/TSTD1	2
GO:0005518	collagen binding	5/428	69/18367	0.0223183746808623	0.200589836637873	ITGB1/ADGRG1/FN1/C1QTNF1/SPARC	5
GO:0022853	active ion transmembrane transporter activity	12/428	267/18367	0.0231710173326299	0.205713422172617	SLC26A2/SLC6A8/ATP2B1/SLC13A4/SLC6A4/ATP2B4/SLC22A18/COX7A2L/SLC5A6/COX6A1/SLC17A5/SLC5A3	12
GO:0023026	MHC class II protein complex binding	3/428	27/18367	0.0242848016275638	0.212071515251541	HSP90AB1/CD81/PKM	3
GO:0048029	monosaccharide binding	5/428	71/18367	0.0249099648845485	0.212071515251541	COLEC12/UGP2/LMAN1/ALDOA/P3H2	5
GO:0000774	adenyl-nucleotide exchange factor activity	2/428	11/18367	0.0259263253535537	0.212071515251541	SIL1/PFN1	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/428	11/18367	0.0259263253535537	0.212071515251541	P4HB/ERO1B	2
GO:0047676	arachidonate-CoA ligase activity	2/428	11/18367	0.0259263253535537	0.212071515251541	SLC27A2/ACSL3	2
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/428	11/18367	0.0259263253535537	0.212071515251541	DSC2/CD47	2
GO:0099186	structural constituent of postsynapse	2/428	11/18367	0.0259263253535537	0.212071515251541	ACTB/ACTG1	2
GO:0003785	actin monomer binding	3/428	28/18367	0.0267403586793738	0.21392286943499	TMSB10/TMSB4X/PFN1	3
GO:0070325	lipoprotein particle receptor binding	3/428	28/18367	0.0267403586793738	0.21392286943499	DNAJA1/CLTC/LRP1	3
GO:0015370	solute:sodium symporter activity	5/428	73/18367	0.0276872150265979	0.219090136297427	SLC6A8/SLC13A4/SLC6A4/SLC5A6/SLC5A3	5
GO:0051059	NF-kappaB binding	3/428	29/18367	0.0293235206098782	0.225304311994668	ANXA4/NPM1/GSK3B	3
GO:0008514	organic anion transmembrane transporter activity	9/428	185/18367	0.0297055493798059	0.225304311994668	SLC26A2/SLC6A8/GJA1/SLC35B4/SLC16A12/SLC35D1/SLC1A5/SLC38A9/SLC5A6	9
GO:0015631	tubulin binding	15/428	375/18367	0.0304377138908676	0.225304311994668	GAPDH/TPPP3/CAPN6/GJA1/DAG1/CCSAP/GAS2L3/ALDOA/BEX4/DST/MID1/EZR/REEP3/FNTA/RPS3	15
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/428	12/18367	0.0306389105597145	0.225304311994668	SLC35B4/SLC35D1	2
GO:0017166	vinculin binding	2/428	12/18367	0.0306389105597145	0.225304311994668	DAG1/UTRN	2
GO:0031543	peptidyl-proline dioxygenase activity	2/428	12/18367	0.0306389105597145	0.225304311994668	P4HB/P3H2	2
GO:0045295	gamma-catenin binding	2/428	12/18367	0.0306389105597145	0.225304311994668	DSC3/CDH1	2
GO:0008238	exopeptidase activity	6/428	103/18367	0.0334199560740273	0.242625359500469	DPP7/MME/DPP4/CTSC/TFRC/LNPEP	6
GO:0015294	solute:cation symporter activity	6/428	104/18367	0.0347985819697055	0.242625359500469	SLC6A8/SLC13A4/SLC6A4/SLC5A6/SLC17A5/SLC5A3	6
GO:0004859	phospholipase inhibitor activity	2/428	13/18367	0.0356605954210854	0.242625359500469	ANXA4/ANXA1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/428	13/18367	0.0356605954210854	0.242625359500469	SLC26A2/SLC13A4	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/428	13/18367	0.0356605954210854	0.242625359500469	DUSP1/DUSP5	2
GO:0034236	protein kinase A catalytic subunit binding	2/428	13/18367	0.0356605954210854	0.242625359500469	EZR/GSK3B	2
GO:0042301	phosphate ion binding	2/428	13/18367	0.0356605954210854	0.242625359500469	PNP/NCEH1	2
GO:0060590	ATPase regulator activity	2/428	13/18367	0.0356605954210854	0.242625359500469	SIL1/PFN1	2
GO:0015459	potassium channel regulator activity	4/428	54/18367	0.0368783224543278	0.248230081042718	SGK1/AKAP9/RASA1/SLC5A3	4
GO:0016835	carbon-oxygen lyase activity	5/428	79/18367	0.0371663170791982	0.248230081042718	TPI1/HACD3/ENO1/HADHA/RPS3	5
GO:0008378	galactosyltransferase activity	3/428	32/18367	0.037832046313253	0.250379361054983	C1GALT1/B4GALT1/B3GNT2	3
GO:0019208	phosphatase regulator activity	6/428	107/18367	0.0391524172588377	0.254490712182445	IGFBP3/CALM1/PPP1R15A/PHACTR2/RCAN1/PPP1R14B	6
GO:0051087	chaperone binding	6/428	107/18367	0.0391524172588377	0.254490712182445	LRP2/CTSC/DNAJA1/PTGES3/SOD1/FN1	6
GO:0015373	anion:sodium symporter activity	2/428	14/18367	0.0409744868549715	0.261661635354555	SLC13A4/SLC6A4	2
GO:0140666	annealing activity	2/428	14/18367	0.0409744868549715	0.261661635354555	EIF4H/ANXA1	2
GO:0047485	protein N-terminus binding	6/428	110/18367	0.0438379267563859	0.271190529965865	NPM1/HSPA1A/CALM1/HSPA1B/SDCBP/EIF5A	6
GO:0008376	acetylgalactosaminyltransferase activity	3/428	34/18367	0.0441271021499351	0.271190529965865	GALNT11/CHPF/EXTL2	3
GO:0099106	ion channel regulator activity	7/428	139/18367	0.0443496825980539	0.271190529965865	SGK1/CALM1/AKAP9/GPD1L/ATP2B4/RASA1/SLC5A3	7
GO:0008028	monocarboxylic acid transmembrane transporter activity	4/428	58/18367	0.0460662423220492	0.271190529965865	SLC27A2/SLC16A12/SLC16A4/SLC5A6	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	4/428	58/18367	0.0460662423220492	0.271190529965865	GSTK1/GSTM3/SMS/FNTA	4
GO:0008135	translation factor activity, RNA binding	5/428	84/18367	0.0464168026274563	0.271190529965865	EIF4H/EIF1/EEF1A1/CPEB4/EIF5A	5
GO:0030165	PDZ domain binding	5/428	84/18367	0.0464168026274563	0.271190529965865	ADRB1/ATP2B1/GJA1/ATP2B4/CRIM1	5
GO:0004467	long-chain fatty acid-CoA ligase activity	2/428	15/18367	0.0465643080298533	0.271190529965865	SLC27A2/ACSL3	2
GO:0030548	acetylcholine receptor regulator activity	2/428	15/18367	0.0465643080298533	0.271190529965865	FNTA/LY6E	2
GO:0032794	GTPase activating protein binding	2/428	15/18367	0.0465643080298533	0.271190529965865	PLXNB1/CDH1	2
GO:0099602	neurotransmitter receptor regulator activity	2/428	15/18367	0.0465643080298533	0.271190529965865	FNTA/LY6E	2
GO:0008194	UDP-glycosyltransferase activity	7/428	143/18367	0.0503024998240732	0.289290585745306	GALNT11/B4GALT1/CHPF/EXTL2/GCNT4/B3GNT2/HEXB	7
GO:0042562	hormone binding	5/428	86/18367	0.05046690163414	0.289290585745306	EGFR/LRP2/INHBA/NR3C1/ALDH1A3	5
GO:0023023	MHC protein complex binding	3/428	36/18367	0.0509081047916272	0.28953984600238	HSP90AB1/CD81/PKM	3
GO:0005092	GDP-dissociation inhibitor activity	2/428	16/18367	0.0524143789279802	0.291279907324959	SH3BP4/CHML	2
GO:0005402	carbohydrate:cation symporter activity	2/428	16/18367	0.0524143789279802	0.291279907324959	SLC17A5/SLC5A3	2
GO:0032183	SUMO binding	2/428	16/18367	0.0524143789279802	0.291279907324959	CBX4/USP25	2
GO:0016247	channel regulator activity	7/428	145/18367	0.0534594666619631	0.294837058559918	SGK1/CALM1/AKAP9/GPD1L/ATP2B4/RASA1/SLC5A3	7
GO:0048306	calcium-dependent protein binding	5/428	88/18367	0.05471799380642	0.297273876799058	ANXA4/ANXA1/CALM1/PDCD6/ATP2B4	5
GO:0051219	phosphoprotein binding	5/428	88/18367	0.05471799380642	0.297273876799058	CBX4/MID1/UBASH3B/RASA1/PFN1	5
GO:0140303	intramembrane lipid transporter activity	3/428	38/18367	0.0581620495273499	0.30643875512538	ANO6/ATP10D/ABCA1	3
GO:0008484	sulfuric ester hydrolase activity	2/428	17/18367	0.0585095974758624	0.30643875512538	GNS/STS	2
GO:0015116	sulfate transmembrane transporter activity	2/428	17/18367	0.0585095974758624	0.30643875512538	SLC26A2/SLC13A4	2
GO:0034185	apolipoprotein binding	2/428	17/18367	0.0585095974758624	0.30643875512538	ABCA1/LRP1	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/428	17/18367	0.0585095974758624	0.30643875512538	C1GALT1/B3GNT2	2
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/428	39/18367	0.0619617856530029	0.322201285395615	BIRC6/UBE2I/UBE2B	3
GO:0033549	MAP kinase phosphatase activity	2/428	18/18367	0.0648354212268436	0.32402906049434	DUSP1/DUSP5	2
GO:0046624	sphingolipid transporter activity	2/428	18/18367	0.0648354212268436	0.32402906049434	ATP10D/ABCA1	2
GO:0055102	lipase inhibitor activity	2/428	18/18367	0.0648354212268436	0.32402906049434	ANXA4/ANXA1	2
GO:0098918	structural constituent of synapse	2/428	18/18367	0.0648354212268436	0.32402906049434	ACTB/ACTG1	2
GO:0015103	inorganic anion transmembrane transporter activity	7/428	152/18367	0.0654697614717578	0.32402906049434	SLC26A2/LRRC8D/SLC13A4/ANO6/CLIC3/SLC6A4/ANKH	7
GO:0004177	aminopeptidase activity	3/428	40/18367	0.0658740397708274	0.32402906049434	DPP7/DPP4/LNPEP	3
GO:0015144	carbohydrate transmembrane transporter activity	3/428	40/18367	0.0658740397708274	0.32402906049434	SLC2A12/SLC17A5/SLC5A3	3
GO:0017080	sodium channel regulator activity	3/428	40/18367	0.0658740397708274	0.32402906049434	SGK1/GPD1L/ATP2B4	3
GO:0043022	ribosome binding	4/428	66/18367	0.0679006465399513	0.331756179067682	RPN2/CPEB4/CCDC47/EIF5A	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/428	41/18367	0.0698967025213448	0.336235962650303	SLC27A2/UBA5/ACSL3	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	3/428	41/18367	0.0698967025213448	0.336235962650303	COL21A1/COL4A2/COL4A1	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	6/428	124/18367	0.0702031130808325	0.336235962650303	MET/EGFR/NRP2/NRP1/EFEMP1/CRIM1	6
GO:0003746	translation elongation factor activity	2/428	19/18367	0.0713778495803653	0.337422561652636	EEF1A1/EIF5A	2
GO:0004129	cytochrome-c oxidase activity	2/428	19/18367	0.0713778495803653	0.337422561652636	COX7A2L/COX6A1	2
GO:0030546	signaling receptor activator activity	17/428	495/18367	0.0728066635671628	0.341176587910321	FBN1/MIF/FAM3B/SEMA6D/EFEMP1/BMP7/GREM2/CMTM8/INHBA/DPP4/SEMA7A/APELA/PGF/APP/GAST/SEMA3F/SEMA4B	17
GO:0001046	core promoter sequence-specific DNA binding	3/428	42/18367	0.0740275816167276	0.341176587910321	CEBPB/NPM1/NR3C1	3
GO:0019843	rRNA binding	4/428	68/18367	0.0740638237980507	0.341176587910321	NPM1/RPL9/RPL23A/RPS3	4
GO:0042826	histone deacetylase binding	6/428	127/18367	0.0768261374584451	0.341176587910321	CEBPB/HSPA1A/BEX4/HSP90AB1/HNRNPD/HSPA1B	6
GO:0003756	protein disulfide isomerase activity	2/428	20/18367	0.0781234065229461	0.341176587910321	P4HB/ERO1B	2
GO:0016500	protein-hormone receptor activity	2/428	20/18367	0.0781234065229461	0.341176587910321	LGR5/LGR4	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/428	20/18367	0.0781234065229461	0.341176587910321	COX7A2L/COX6A1	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/428	20/18367	0.0781234065229461	0.341176587910321	P4HB/ERO1B	2
GO:0030506	ankyrin binding	2/428	20/18367	0.0781234065229461	0.341176587910321	NRCAM/CDH1	2
GO:0031690	adrenergic receptor binding	2/428	20/18367	0.0781234065229461	0.341176587910321	ADRB1/ARRDC3	2
GO:0061608	nuclear import signal receptor activity	2/428	20/18367	0.0781234065229461	0.341176587910321	TNPO1/NUTF2	2
GO:0016504	peptidase activator activity	3/428	43/18367	0.0782644095893181	0.341176587910321	CTSC/FN1/APP	3
GO:0030544	Hsp70 protein binding	3/428	43/18367	0.0782644095893181	0.341176587910321	DNAJA1/DNAJC8/RPS3	3
GO:0140678	molecular function inhibitor activity	6/428	128/18367	0.0791098316245591	0.342809270373089	ANXA4/DYNLL1/ANXA1/CALM1/OAZ1/RASA1	6
GO:0004857	enzyme inhibitor activity	4/428	70/18367	0.0805000958103221	0.346769643490618	ANXA4/DYNLL1/ANXA1/OAZ1	4
GO:0051879	Hsp90 protein binding	3/428	44/18367	0.0826048511625448	0.353743127331368	NR3C1/PTGES3/RPS3	3
GO:0001614	purinergic nucleotide receptor activity	2/428	21/18367	0.0850591238763059	0.353845955325433	P2RY6/P2RX4	2
GO:0005243	gap junction channel activity	2/428	21/18367	0.0850591238763059	0.353845955325433	GJA1/GJA5	2
GO:0015662	P-type ion transporter activity	2/428	21/18367	0.0850591238763059	0.353845955325433	ATP2B1/ATP2B4	2
GO:0016502	nucleotide receptor activity	2/428	21/18367	0.0850591238763059	0.353845955325433	P2RY6/P2RX4	2
GO:0140358	P-type transmembrane transporter activity	2/428	21/18367	0.0850591238763059	0.353845955325433	ATP2B1/ATP2B4	2
GO:0046943	carboxylic acid transmembrane transporter activity	7/428	163/18367	0.0873875075094657	0.361466508334608	SLC26A2/SLC27A2/SLC16A12/SLC16A4/SLC1A5/SLC38A9/SLC5A6	7
GO:0005342	organic acid transmembrane transporter activity	7/428	164/18367	0.0895640262837177	0.362711341772954	SLC26A2/SLC27A2/SLC16A12/SLC16A4/SLC1A5/SLC38A9/SLC5A6	7
GO:0035064	methylated histone binding	4/428	73/18367	0.090654075682418	0.362711341772954	MORC4/CBX4/MPHOSPH8/KMT2E	4
GO:0140034	methylation-dependent protein binding	4/428	73/18367	0.090654075682418	0.362711341772954	MORC4/CBX4/MPHOSPH8/KMT2E	4
GO:0005355	glucose transmembrane transporter activity	2/428	22/18367	0.0921725250384568	0.362711341772954	SLC2A12/SLC5A3	2
GO:0008093	cytoskeletal anchor activity	2/428	22/18367	0.0921725250384568	0.362711341772954	GAS2L3/SDCBP	2
GO:0015149	hexose transmembrane transporter activity	2/428	22/18367	0.0921725250384568	0.362711341772954	SLC2A12/SLC5A3	2
GO:0015296	anion:cation symporter activity	2/428	22/18367	0.0921725250384568	0.362711341772954	SLC13A4/SLC6A4	2
GO:0015645	fatty acid ligase activity	2/428	22/18367	0.0921725250384568	0.362711341772954	SLC27A2/ACSL3	2
GO:0070182	DNA polymerase binding	2/428	22/18367	0.0921725250384568	0.362711341772954	HSP90AB1/PTGES3	2
GO:0003725	double-stranded RNA binding	4/428	74/18367	0.0941687887028292	0.368574613847633	EIF4H/HSP90AB1/CLTC/TFRC	4
GO:0015085	calcium ion transmembrane transporter activity	6/428	135/18367	0.0961477412924158	0.372610661361055	ATP2B1/TMEM37/ITPR2/ITGAV/P2RX4/ATP2B4	6
GO:0005044	scavenger receptor activity	3/428	47/18367	0.0962236323295032	0.372610661361055	COLEC12/LGALS3BP/LRP1	3
GO:0004713	protein tyrosine kinase activity	6/428	136/18367	0.0987300904290378	0.37708735156503	MET/EGFR/NRP2/NRP1/EFEMP1/CRIM1	6
GO:0017134	fibroblast growth factor binding	2/428	23/18367	0.0994516092039639	0.37708735156503	ITGAV/GLG1	2
GO:0050750	low-density lipoprotein particle receptor binding	2/428	23/18367	0.0994516092039639	0.37708735156503	DNAJA1/CLTC	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/428	23/18367	0.0994516092039639	0.37708735156503	C1GALT1/GCNT4	2
GO:0008017	microtubule binding	10/428	271/18367	0.10319422342412	0.387125177335168	GAPDH/CAPN6/CCSAP/GAS2L3/DST/MID1/EZR/REEP3/FNTA/RPS3	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	7/428	170/18367	0.103258015807242	0.387125177335168	CYP2J2/SCD/ASPH/CYP11A1/P4HB/P3H2/HMOX1	7
GO:0016763	pentosyltransferase activity	3/428	49/18367	0.105775635957894	0.387125177335168	PNP/UPP1/UMPS	3
GO:0098632	cell-cell adhesion mediator activity	3/428	49/18367	0.105775635957894	0.387125177335168	DSC2/ANXA1/CD47	3
GO:0048018	receptor ligand activity	16/428	487/18367	0.106827579612981	0.387125177335168	FBN1/MIF/FAM3B/SEMA6D/EFEMP1/BMP7/GREM2/CMTM8/INHBA/DPP4/SEMA7A/APELA/PGF/GAST/SEMA3F/SEMA4B	16
GO:0015145	monosaccharide transmembrane transporter activity	2/428	24/18367	0.106884836049957	0.387125177335168	SLC2A12/SLC5A3	2
GO:0019789	SUMO transferase activity	2/428	24/18367	0.106884836049957	0.387125177335168	CBX4/UBE2I	2
GO:0043495	protein-membrane adaptor activity	2/428	24/18367	0.106884836049957	0.387125177335168	PDCD6/SYNE2	2
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	2/428	24/18367	0.106884836049957	0.387125177335168	BMP7/INHBA	2
GO:0090079	translation regulator activity, nucleic acid binding	5/428	108/18367	0.108091866944675	0.389558807602589	EIF4H/EIF1/EEF1A1/CPEB4/EIF5A	5
GO:0070851	growth factor receptor binding	6/428	141/18367	0.112184710854911	0.402317583755544	EFEMP1/FAM83B/PGF/IL6ST/APP/SDCBP	6
GO:0008266	poly(U) RNA binding	2/428	25/18367	0.114461110874833	0.402549220854483	MSI2/HNRNPC	2
GO:0034237	protein kinase A regulatory subunit binding	2/428	25/18367	0.114461110874833	0.402549220854483	AKAP9/EZR	2
GO:0035035	histone acetyltransferase binding	2/428	25/18367	0.114461110874833	0.402549220854483	CEBPB/EGR1	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/428	25/18367	0.114461110874833	0.402549220854483	MEX3D/HNRNPD	2
GO:0019199	transmembrane receptor protein kinase activity	6/428	143/18367	0.117815146498706	0.41235301274547	MET/EGFR/NRP2/NRP1/EFEMP1/CRIM1	6
GO:0004364	glutathione transferase activity	2/428	26/18367	0.122169770176939	0.421514657292946	GSTK1/GSTM3	2
GO:0008198	ferrous iron binding	2/428	26/18367	0.122169770176939	0.421514657292946	CDO1/FTL	2
GO:0099604	ligand-gated calcium channel activity	2/428	26/18367	0.122169770176939	0.421514657292946	ITPR2/P2RX4	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	4/428	82/18367	0.124496398620193	0.427515934884435	SCIN/TTPA/PFN1/SDCBP	4
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/428	53/18367	0.125920995447707	0.43037786237526	SLC35B4/SLC35D1/SLC17A5	3
GO:0004709	MAP kinase kinase kinase activity	2/428	27/18367	0.130000567660889	0.436130936668789	EGFR/MAP3K4	2
GO:0016405	CoA-ligase activity	2/428	27/18367	0.130000567660889	0.436130936668789	SLC27A2/ACSL3	2
GO:0051119	sugar transmembrane transporter activity	2/428	27/18367	0.130000567660889	0.436130936668789	SLC2A12/SLC5A3	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/428	27/18367	0.130000567660889	0.436130936668789	ATP10D/ABCA1	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/428	54/18367	0.131158799741435	0.437998193631947	ASPH/P4HB/P3H2	3
GO:0046873	metal ion transmembrane transporter activity	14/428	430/18367	0.131814761166361	0.438178749447994	SLC6A8/ATP2B1/TMEM37/SLC13A4/SLC39A10/SLC6A4/ITPR2/ITGAV/TUSC3/P2RX4/ATP2B4/SLC5A6/KCNK5/SLC5A3	14
GO:0005080	protein kinase C binding	3/428	55/18367	0.136471826146737	0.450327286816557	SDC4/DACT2/ITGAV	3
GO:0008187	poly-pyrimidine tract binding	2/428	28/18367	0.137943660659467	0.450327286816557	MSI2/HNRNPC	2
GO:0015101	organic cation transmembrane transporter activity	2/428	28/18367	0.137943660659467	0.450327286816557	SLC19A3/SLC44A1	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/428	28/18367	0.137943660659467	0.450327286816557	PDCD6/HERPUD1	2
GO:0005506	iron ion binding	6/428	151/18367	0.141697241695111	0.458987439915055	CYP2J2/SCD/CDO1/CYP11A1/P3H2/FTL	6
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/428	56/18367	0.141857381841878	0.458987439915055	SERPINB9/BIRC6/CST3	3
GO:0033612	receptor serine/threonine kinase binding	2/428	29/18367	0.145989596959437	0.466142221870482	BMP7/INHBA	2
GO:0035250	UDP-galactosyltransferase activity	2/428	29/18367	0.145989596959437	0.466142221870482	B4GALT1/B3GNT2	2
GO:0051787	misfolded protein binding	2/428	29/18367	0.145989596959437	0.466142221870482	HSPA1A/HSPA1B	2
GO:0008022	protein C-terminus binding	7/428	189/18367	0.153487699631108	0.481571381418284	BCAM/DST/EZR/TBL1X/FN1/SDC1/SDCBP	7
GO:0051117	ATPase binding	4/428	89/18367	0.153964830662772	0.481571381418284	EGFR/EZR/USP25/ABCA1	4
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/428	30/18367	0.154129302019863	0.481571381418284	SLC26A2/SLC1A5	2
GO:0017147	Wnt-protein binding	2/428	30/18367	0.154129302019863	0.481571381418284	WLS/LRP5	2
GO:0022829	wide pore channel activity	2/428	30/18367	0.154129302019863	0.481571381418284	GJA1/GJA5	2
GO:0000146	microfilament motor activity	2/428	31/18367	0.162354066571878	0.492474001934696	MYL6/MYO5B	2
GO:0016878	acid-thiol ligase activity	2/428	31/18367	0.162354066571878	0.492474001934696	SLC27A2/ACSL3	2
GO:0071813	lipoprotein particle binding	2/428	31/18367	0.162354066571878	0.492474001934696	COLEC12/ABCA1	2
GO:0071814	protein-lipid complex binding	2/428	31/18367	0.162354066571878	0.492474001934696	COLEC12/ABCA1	2
GO:0090482	vitamin transmembrane transporter activity	2/428	31/18367	0.162354066571878	0.492474001934696	SLC19A3/SLC5A6	2
GO:0140142	nucleocytoplasmic carrier activity	2/428	31/18367	0.162354066571878	0.492474001934696	TNPO1/NUTF2	2
GO:0140318	protein transporter activity	2/428	31/18367	0.162354066571878	0.492474001934696	LRP2/ABCA1	2
GO:0051213	dioxygenase activity	4/428	92/18367	0.16732944525879	0.505459901030701	ASPH/CDO1/P4HB/P3H2	4
GO:0005507	copper ion binding	3/428	61/18367	0.169779016671062	0.510740182382369	F5/P2RX4/SOD1	3
GO:0016829	lyase activity	7/428	196/18367	0.174413479009426	0.520381199667469	TPI1/HACD3/ALDOA/UMPS/ENO1/HADHA/RPS3	7
GO:0019902	phosphatase binding	7/428	196/18367	0.174413479009426	0.520381199667469	MET/EGFR/CTSC/PPP1R15A/ATP2B4/SOD1/SH2D4A	7
GO:0005154	epidermal growth factor receptor binding	2/428	33/18367	0.17902569161836	0.527654670033061	EFEMP1/FAM83B	2
GO:0008200	ion channel inhibitor activity	2/428	33/18367	0.17902569161836	0.527654670033061	CALM1/RASA1	2
GO:0019956	chemokine binding	2/428	33/18367	0.17902569161836	0.527654670033061	ITGB1/ITGAV	2
GO:0030246	carbohydrate binding	9/428	271/18367	0.183214068329327	0.533195382351123	GALNT11/OLR1/COLEC12/AGL/UGP2/LMAN1/ALDOA/P3H2/MAN2A1	9
GO:0015078	proton transmembrane transporter activity	5/428	130/18367	0.1871277183496	0.533195382351123	SLC22A18/COX7A2L/COX6A1/ATP6V1B1/SLC17A5	5
GO:0016836	hydro-lyase activity	3/428	64/18367	0.18723113754194	0.533195382351123	HACD3/ENO1/HADHA	3
GO:0016248	channel inhibitor activity	2/428	34/18367	0.187456853460137	0.533195382351123	CALM1/RASA1	2
GO:0035198	miRNA binding	2/428	34/18367	0.187456853460137	0.533195382351123	HNRNPA1/NEAT1	2
GO:0043548	phosphatidylinositol 3-kinase binding	2/428	34/18367	0.187456853460137	0.533195382351123	CALM1/FAM83B	2
GO:0005516	calmodulin binding	7/428	201/18367	0.190071818186282	0.533195382351123	EGFR/ATP2B1/ADD3/ATP2B4/MYO5B/EDF1/PHKB	7
GO:0004896	cytokine receptor activity	4/428	97/18367	0.190462356245289	0.533195382351123	CSF3R/LIFR/CSF2RA/IL6ST	4
GO:0030145	manganese ion binding	3/428	65/18367	0.193149271276101	0.533195382351123	GLUL/B4GALT1/EXTL2	3
GO:0042887	amide transmembrane transporter activity	2/428	35/18367	0.195941655189463	0.533195382351123	GJA1/SLC5A6	2
GO:0002039	p53 binding	3/428	66/18367	0.199113491501632	0.533195382351123	SMYD2/SETD7/GSK3B	3
GO:0000217	DNA secondary structure binding	2/428	36/18367	0.204473040506983	0.533195382351123	HMGB3/HNRNPD	2
GO:0042162	telomeric DNA binding	2/428	36/18367	0.204473040506983	0.533195382351123	HNRNPA1/HNRNPD	2
GO:0061631	ubiquitin conjugating enzyme activity	2/428	36/18367	0.204473040506983	0.533195382351123	BIRC6/UBE2B	2
GO:0001094	TFIID-class transcription factor complex binding	1/428	10/18367	0.210095399324786	0.533195382351123	EDF1	1
GO:0004300	enoyl-CoA hydratase activity	1/428	10/18367	0.210095399324786	0.533195382351123	HADHA	1
GO:0004955	prostaglandin receptor activity	1/428	10/18367	0.210095399324786	0.533195382351123	HPGD	1
GO:0005522	profilin binding	1/428	10/18367	0.210095399324786	0.533195382351123	ACTG1	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/428	10/18367	0.210095399324786	0.533195382351123	UBA5	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/428	10/18367	0.210095399324786	0.533195382351123	MAN2A1	1
GO:0016595	glutamate binding	1/428	10/18367	0.210095399324786	0.533195382351123	GLUL	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/428	10/18367	0.210095399324786	0.533195382351123	SCD	1
GO:0019531	oxalate transmembrane transporter activity	1/428	10/18367	0.210095399324786	0.533195382351123	SLC26A2	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/428	10/18367	0.210095399324786	0.533195382351123	SLC27A2	1
GO:0032356	oxidized DNA binding	1/428	10/18367	0.210095399324786	0.533195382351123	RPS3	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/428	10/18367	0.210095399324786	0.533195382351123	FAM83B	1
GO:0043208	glycosphingolipid binding	1/428	10/18367	0.210095399324786	0.533195382351123	PSAP	1
GO:0045503	dynein light chain binding	1/428	10/18367	0.210095399324786	0.533195382351123	GLUL	1
GO:0070567	cytidylyltransferase activity	1/428	10/18367	0.210095399324786	0.533195382351123	CDS1	1
GO:0098505	G-rich strand telomeric DNA binding	1/428	10/18367	0.210095399324786	0.533195382351123	HNRNPA1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/428	10/18367	0.210095399324786	0.533195382351123	ADRB1	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3/428	68/18367	0.211170064289697	0.533195382351123	MOCS2/HS6ST2/TSTD1	3
GO:0005109	frizzled binding	2/428	37/18367	0.213044251411176	0.533195382351123	RNF43/SDCBP	2
GO:0015035	protein-disulfide reductase activity	2/428	37/18367	0.213044251411176	0.533195382351123	P4HB/ERO1B	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/428	37/18367	0.213044251411176	0.533195382351123	GAPDH/ALDH1A3	2
GO:0042056	chemoattractant activity	2/428	37/18367	0.213044251411176	0.533195382351123	MIF/PGF	2
GO:0004725	protein tyrosine phosphatase activity	4/428	102/18367	0.214532568936089	0.533195382351123	DUSP1/PTPRF/DUSP5/UBASH3B	4
GO:0042277	peptide binding	10/428	321/18367	0.217700066547386	0.533195382351123	ITM2B/TNPO1/MME/INHBA/HSP90AB1/CST3/GSTM3/PPIA/LNPEP/LRP1	10
GO:0005200	structural constituent of cytoskeleton	4/428	103/18367	0.219445185587901	0.533195382351123	KRT19/ACTB/ACTG1/ADD3	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/428	38/18367	0.2216488181825	0.533195382351123	PPIA/FKBP14	2
GO:0008395	steroid hydroxylase activity	2/428	38/18367	0.2216488181825	0.533195382351123	CYP2J2/CYP11A1	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/428	38/18367	0.2216488181825	0.533195382351123	SLC1A5/SLC38A9	2
GO:0033218	amide binding	12/428	400/18367	0.225177466390801	0.533195382351123	ITM2B/TNPO1/MME/PSAP/INHBA/HSP90AB1/CST3/GSTM3/PPIA/LNPEP/HADHA/LRP1	12
GO:0002162	dystroglycan binding	1/428	11/18367	0.22851230672191	0.533195382351123	DAG1	1
GO:0004954	prostanoid receptor activity	1/428	11/18367	0.22851230672191	0.533195382351123	HPGD	1
GO:0005247	voltage-gated chloride channel activity	1/428	11/18367	0.22851230672191	0.533195382351123	ANO6	1
GO:0005536	glucose binding	1/428	11/18367	0.22851230672191	0.533195382351123	UGP2	1
GO:0008199	ferric iron binding	1/428	11/18367	0.22851230672191	0.533195382351123	FTL	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/428	11/18367	0.22851230672191	0.533195382351123	PKIB	1
GO:0015378	sodium:chloride symporter activity	1/428	11/18367	0.22851230672191	0.533195382351123	SLC6A4	1
GO:0016832	aldehyde-lyase activity	1/428	11/18367	0.22851230672191	0.533195382351123	ALDOA	1
GO:0017128	phospholipid scramblase activity	1/428	11/18367	0.22851230672191	0.533195382351123	ANO6	1
GO:0019855	calcium channel inhibitor activity	1/428	11/18367	0.22851230672191	0.533195382351123	CALM1	1
GO:0022889	serine transmembrane transporter activity	1/428	11/18367	0.22851230672191	0.533195382351123	SLC1A5	1
GO:0035673	oligopeptide transmembrane transporter activity	1/428	11/18367	0.22851230672191	0.533195382351123	GJA1	1
GO:0042608	T cell receptor binding	1/428	11/18367	0.22851230672191	0.533195382351123	EPS8L1	1
GO:0043295	glutathione binding	1/428	11/18367	0.22851230672191	0.533195382351123	GSTM3	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/428	11/18367	0.22851230672191	0.533195382351123	SMYD2	1
GO:0048407	platelet-derived growth factor binding	1/428	11/18367	0.22851230672191	0.533195382351123	COL4A1	1
GO:0061665	SUMO ligase activity	1/428	11/18367	0.22851230672191	0.533195382351123	CBX4	1
GO:0070697	activin receptor binding	1/428	11/18367	0.22851230672191	0.533195382351123	INHBA	1
GO:1901474	azole transmembrane transporter activity	1/428	11/18367	0.22851230672191	0.533195382351123	SLC19A3	1
GO:1901612	cardiolipin binding	1/428	11/18367	0.22851230672191	0.533195382351123	MME	1
GO:1990226	histone methyltransferase binding	1/428	11/18367	0.22851230672191	0.533195382351123	HSP90AB1	1
GO:1990459	transferrin receptor binding	1/428	11/18367	0.22851230672191	0.533195382351123	CD81	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/428	40/18367	0.238933523875831	0.539683572990537	CYP2J2/HMOX1	2
GO:0031492	nucleosomal DNA binding	2/428	40/18367	0.238933523875831	0.539683572990537	ACTB/HNRNPC	2
GO:0042169	SH2 domain binding	2/428	40/18367	0.238933523875831	0.539683572990537	DAG1/ARHGAP5	2
GO:0043014	alpha-tubulin binding	2/428	40/18367	0.238933523875831	0.539683572990537	BEX4/FNTA	2
GO:1902936	phosphatidylinositol bisphosphate binding	4/428	107/18367	0.239382192682248	0.539683572990537	SCIN/TTPA/PFN1/SDCBP	4
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/428	12/18367	0.246500797282109	0.539683572990537	RPS3	1
GO:0003964	RNA-directed DNA polymerase activity	1/428	12/18367	0.246500797282109	0.539683572990537	PTGES3	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/428	12/18367	0.246500797282109	0.539683572990537	CDK6	1
GO:0015166	polyol transmembrane transporter activity	1/428	12/18367	0.246500797282109	0.539683572990537	SLC5A3	1
GO:0030955	potassium ion binding	1/428	12/18367	0.246500797282109	0.539683572990537	PKM	1
GO:0033130	acetylcholine receptor binding	1/428	12/18367	0.246500797282109	0.539683572990537	LY6E	1
GO:0034452	dynactin binding	1/428	12/18367	0.246500797282109	0.539683572990537	GSK3B	1
GO:0035256	G protein-coupled glutamate receptor binding	1/428	12/18367	0.246500797282109	0.539683572990537	CALM1	1
GO:0043047	single-stranded telomeric DNA binding	1/428	12/18367	0.246500797282109	0.539683572990537	HNRNPA1	1
GO:0043176	amine binding	1/428	12/18367	0.246500797282109	0.539683572990537	SLC6A4	1
GO:0043422	protein kinase B binding	1/428	12/18367	0.246500797282109	0.539683572990537	SRSF5	1
GO:0046790	virion binding	1/428	12/18367	0.246500797282109	0.539683572990537	PPIA	1
GO:0051378	serotonin binding	1/428	12/18367	0.246500797282109	0.539683572990537	SLC6A4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/428	12/18367	0.246500797282109	0.539683572990537	USP27X	1
GO:1900750	oligopeptide binding	1/428	12/18367	0.246500797282109	0.539683572990537	GSTM3	1
GO:0015399	primary active transmembrane transporter activity	6/428	181/18367	0.247576029841282	0.539683572990537	SLC26A2/ATP2B1/ATP2B4/ABCA1/COX7A2L/COX6A1	6
GO:0016859	cis-trans isomerase activity	2/428	41/18367	0.247602078817087	0.539683572990537	PPIA/FKBP14	2
GO:0042626	ATPase-coupled transmembrane transporter activity	4/428	109/18367	0.249505113762296	0.540284185241659	SLC26A2/ATP2B1/ATP2B4/ABCA1	4
GO:0030695	GTPase regulator activity	14/428	488/18367	0.250104080256098	0.540284185241659	SYDE1/ADRB1/HACD3/NRP1/PLXNB1/SH3BP4/DEPDC1B/GNAQ/CHML/C9orf72/EPS8L1/RABGAP1L/RASA1/ARHGAP5	14
GO:0060589	nucleoside-triphosphatase regulator activity	14/428	488/18367	0.250104080256098	0.540284185241659	SYDE1/ADRB1/HACD3/NRP1/PLXNB1/SH3BP4/DEPDC1B/GNAQ/CHML/C9orf72/EPS8L1/RABGAP1L/RASA1/ARHGAP5	14
GO:0019003	GDP binding	3/428	75/18367	0.25445624690134	0.546442430591173	RHOB/RAB2A/ARF1	3
GO:0015036	disulfide oxidoreductase activity	2/428	42/18367	0.256280803677105	0.546442430591173	P4HB/ERO1B	2
GO:0000287	magnesium ion binding	7/428	221/18367	0.257718138881379	0.546442430591173	GLUL/PDCD6/ATP10D/ENO1/PKM/ARF1/RPS6KA5	7
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/428	13/18367	0.264070814103861	0.546442430591173	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/428	13/18367	0.264070814103861	0.546442430591173	ABCA1	1
GO:0008179	adenylate cyclase binding	1/428	13/18367	0.264070814103861	0.546442430591173	CALM1	1
GO:0008195	phosphatidate phosphatase activity	1/428	13/18367	0.264070814103861	0.546442430591173	PLPP3	1
GO:0031386	protein tag	1/428	13/18367	0.264070814103861	0.546442430591173	UBC	1
GO:0031404	chloride ion binding	1/428	13/18367	0.264070814103861	0.546442430591173	CTSC	1
GO:0031432	titin binding	1/428	13/18367	0.264070814103861	0.546442430591173	CALM1	1
GO:0032036	myosin heavy chain binding	1/428	13/18367	0.264070814103861	0.546442430591173	MYL12B	1
GO:0052650	NADP-retinol dehydrogenase activity	1/428	13/18367	0.264070814103861	0.546442430591173	RDH13	1
GO:0070679	inositol 1,4,5 trisphosphate binding	1/428	13/18367	0.264070814103861	0.546442430591173	ITPR2	1
GO:0070700	BMP receptor binding	1/428	13/18367	0.264070814103861	0.546442430591173	BMP7	1
GO:0005246	calcium channel regulator activity	2/428	43/18367	0.264964530217973	0.546442430591173	SGK1/CALM1	2
GO:0018024	histone-lysine N-methyltransferase activity	2/428	43/18367	0.264964530217973	0.546442430591173	SMYD2/SETD7	2
GO:0003714	transcription corepressor activity	6/428	187/18367	0.271089608139063	0.554842674779265	HSPA1A/CBX4/SAP18/BASP1/TBL1X/CREG1	6
GO:0019903	protein phosphatase binding	5/428	150/18367	0.272133555606962	0.554842674779265	MET/EGFR/PPP1R15A/ATP2B4/SOD1	5
GO:0001784	phosphotyrosine residue binding	2/428	44/18367	0.273648324458708	0.554842674779265	RASA1/PFN1	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/428	44/18367	0.273648324458708	0.554842674779265	GAPDH/ALDH1A3	2
GO:0015081	sodium ion transmembrane transporter activity	5/428	152/18367	0.281082548399897	0.554842674779265	SLC6A8/SLC13A4/SLC6A4/SLC5A6/SLC5A3	5
GO:0004065	arylsulfatase activity	1/428	14/18367	0.281232070046083	0.554842674779265	STS	1
GO:0005172	vascular endothelial growth factor receptor binding	1/428	14/18367	0.281232070046083	0.554842674779265	PGF	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/428	14/18367	0.281232070046083	0.554842674779265	B3GNT2	1
GO:0015562	efflux transmembrane transporter activity	1/428	14/18367	0.281232070046083	0.554842674779265	GJA1	1
GO:0015926	glucosidase activity	1/428	14/18367	0.281232070046083	0.554842674779265	AGL	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/428	14/18367	0.281232070046083	0.554842674779265	MIF	1
GO:0019992	diacylglycerol binding	1/428	14/18367	0.281232070046083	0.554842674779265	CHPT1	1
GO:0035259	glucocorticoid receptor binding	1/428	14/18367	0.281232070046083	0.554842674779265	CEBPB	1
GO:0043023	ribosomal large subunit binding	1/428	14/18367	0.281232070046083	0.554842674779265	NPM1	1
GO:0044548	S100 protein binding	1/428	14/18367	0.281232070046083	0.554842674779265	EZR	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/428	14/18367	0.281232070046083	0.554842674779265	P2RY6	1
GO:0005096	GTPase activator activity	13/428	462/18367	0.282661876885983	0.554887769926228	SYDE1/ADRB1/HACD3/NRP1/PLXNB1/DEPDC1B/GNAQ/CHML/C9orf72/EPS8L1/RABGAP1L/RASA1/ARHGAP5	13
GO:0005319	lipid transporter activity	5/428	154/18367	0.290088497405982	0.554887769926228	SLC27A2/ANO6/ATP10D/TTPA/ABCA1	5
GO:0004864	protein phosphatase inhibitor activity	2/428	46/18367	0.290997503241517	0.554887769926228	PHACTR2/PPP1R14B	2
GO:0061980	regulatory RNA binding	2/428	46/18367	0.290997503241517	0.554887769926228	HNRNPA1/NEAT1	2
GO:0001846	opsonin binding	1/428	15/18367	0.297994053047243	0.554887769926228	ITGAV	1
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/428	15/18367	0.297994053047243	0.554887769926228	ALDH1A3	1
GO:0004559	alpha-mannosidase activity	1/428	15/18367	0.297994053047243	0.554887769926228	MAN2A1	1
GO:0004953	icosanoid receptor activity	1/428	15/18367	0.297994053047243	0.554887769926228	HPGD	1
GO:0005545	1-phosphatidylinositol binding	1/428	15/18367	0.297994053047243	0.554887769926228	SCIN	1
GO:0010851	cyclase regulator activity	1/428	15/18367	0.297994053047243	0.554887769926228	CALM1	1
GO:0015929	hexosaminidase activity	1/428	15/18367	0.297994053047243	0.554887769926228	HEXB	1
GO:0034483	heparan sulfate sulfotransferase activity	1/428	15/18367	0.297994053047243	0.554887769926228	HS6ST2	1
GO:0042043	neurexin family protein binding	1/428	15/18367	0.297994053047243	0.554887769926228	SDCBP	1
GO:0042813	Wnt-activated receptor activity	1/428	15/18367	0.297994053047243	0.554887769926228	LRP5	1
GO:0098847	sequence-specific single stranded DNA binding	1/428	15/18367	0.297994053047243	0.554887769926228	HNRNPA1	1
GO:1901611	phosphatidylglycerol binding	1/428	15/18367	0.297994053047243	0.554887769926228	MME	1
GO:1904680	peptide transmembrane transporter activity	1/428	15/18367	0.297994053047243	0.554887769926228	GJA1	1
GO:1990825	sequence-specific mRNA binding	1/428	15/18367	0.297994053047243	0.554887769926228	SRSF3	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/428	47/18367	0.299654119726496	0.554887769926228	DUSP1/DUSP5	2
GO:0019829	ATPase-coupled cation transmembrane transporter activity	2/428	47/18367	0.299654119726496	0.554887769926228	ATP2B1/ATP2B4	2
GO:0005262	calcium channel activity	4/428	119/18367	0.301272866295839	0.554887769926228	TMEM37/ITPR2/ITGAV/P2RX4	4
GO:0120013	lipid transfer activity	2/428	48/18367	0.30829325287032	0.554887769926228	TTPA/ABCA1	2
GO:0001540	amyloid-beta binding	3/428	84/18367	0.311609922304571	0.554887769926228	ITM2B/CST3/LRP1	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/428	16/18367	0.31436603132186	0.554887769926228	CPEB4	1
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/428	16/18367	0.31436603132186	0.554887769926228	ALDH1A3	1
GO:0005521	lamin binding	1/428	16/18367	0.31436603132186	0.554887769926228	BNIP3L	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/428	16/18367	0.31436603132186	0.554887769926228	SLC1A5	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/428	16/18367	0.31436603132186	0.554887769926228	SLC1A5	1
GO:0015923	mannosidase activity	1/428	16/18367	0.31436603132186	0.554887769926228	MAN2A1	1
GO:0016004	phospholipase activator activity	1/428	16/18367	0.31436603132186	0.554887769926228	ARF1	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/428	16/18367	0.31436603132186	0.554887769926228	MAOA	1
GO:0017070	U6 snRNA binding	1/428	16/18367	0.31436603132186	0.554887769926228	EIF5A	1
GO:0022841	potassium ion leak channel activity	1/428	16/18367	0.31436603132186	0.554887769926228	KCNK5	1
GO:0036122	BMP binding	1/428	16/18367	0.31436603132186	0.554887769926228	GREM2	1
GO:0042577	lipid phosphatase activity	1/428	16/18367	0.31436603132186	0.554887769926228	PLPP3	1
GO:0140327	flippase activity	1/428	16/18367	0.31436603132186	0.554887769926228	ATP10D	1
GO:1990380	Lys48-specific deubiquitinase activity	1/428	16/18367	0.31436603132186	0.554887769926228	USP27X	1
GO:0019212	phosphatase inhibitor activity	2/428	49/18367	0.316911023802763	0.554887769926228	PHACTR2/PPP1R14B	2
GO:0005179	hormone activity	4/428	122/18367	0.317063041957784	0.554887769926228	FBN1/INHBA/APELA/GAST	4
GO:0140030	modification-dependent protein binding	5/428	160/18367	0.317387949276435	0.554887769926228	MORC4/AGL/CBX4/MPHOSPH8/KMT2E	5
GO:0003697	single-stranded DNA binding	4/428	123/18367	0.322342500134552	0.554887769926228	HNRNPA1/ANXA1/SUB1/TOP1	4
GO:0015485	cholesterol binding	2/428	50/18367	0.32550374307552	0.554887769926228	CD81/ABCA1	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	2/428	50/18367	0.32550374307552	0.554887769926228	SLC35B4/SLC35D1	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4/428	124/18367	0.327628179992464	0.554887769926228	LDHA/RDH13/HPGD/HADHA	4
GO:0003730	mRNA 3'-UTR binding	6/428	201/18367	0.327762881258434	0.554887769926228	MEX3D/SECISBP2L/IGF2BP3/HNRNPD/HNRNPC/CPEB4	6
GO:0000400	four-way junction DNA binding	1/428	17/18367	0.330357058437235	0.554887769926228	HMGB3	1
GO:0004659	prenyltransferase activity	1/428	17/18367	0.330357058437235	0.554887769926228	FNTA	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/428	17/18367	0.330357058437235	0.554887769926228	PTPRF	1
GO:0005324	long-chain fatty acid transporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	SLC27A2	1
GO:0008308	voltage-gated anion channel activity	1/428	17/18367	0.330357058437235	0.554887769926228	ANO6	1
GO:0008381	mechanosensitive ion channel activity	1/428	17/18367	0.330357058437235	0.554887769926228	TMEM150C	1
GO:0008392	arachidonic acid epoxygenase activity	1/428	17/18367	0.330357058437235	0.554887769926228	CYP2J2	1
GO:0008525	phosphatidylcholine transporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	ABCA1	1
GO:0015095	magnesium ion transmembrane transporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	SLC38A9	1
GO:0015278	calcium-release channel activity	1/428	17/18367	0.330357058437235	0.554887769926228	ITPR2	1
GO:0015377	cation:chloride symporter activity	1/428	17/18367	0.330357058437235	0.554887769926228	SLC6A4	1
GO:0017081	chloride channel regulator activity	1/428	17/18367	0.330357058437235	0.554887769926228	SGK1	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/428	17/18367	0.330357058437235	0.554887769926228	PTPRF	1
GO:0030169	low-density lipoprotein particle binding	1/428	17/18367	0.330357058437235	0.554887769926228	COLEC12	1
GO:0031420	alkali metal ion binding	1/428	17/18367	0.330357058437235	0.554887769926228	PKM	1
GO:0043395	heparan sulfate proteoglycan binding	1/428	17/18367	0.330357058437235	0.554887769926228	LRP1	1
GO:0070064	proline-rich region binding	1/428	17/18367	0.330357058437235	0.554887769926228	PFN1	1
GO:0005253	anion channel activity	3/428	87/18367	0.330798478225251	0.554887769926228	LRRC8D/ANO6/CLIC3	3
GO:0003743	translation initiation factor activity	2/428	51/18367	0.334067903975948	0.559083756539058	EIF4H/EIF1	2
GO:0004879	nuclear receptor activity	2/428	52/18367	0.34260017604839	0.566001150972688	NR3C1/NR2F2	2
GO:0016830	carbon-carbon lyase activity	2/428	52/18367	0.34260017604839	0.566001150972688	ALDOA/UMPS	2
GO:0098531	ligand-activated transcription factor activity	2/428	52/18367	0.34260017604839	0.566001150972688	NR3C1/NR2F2	2
GO:0015297	antiporter activity	3/428	89/18367	0.343585306482191	0.566001150972688	SLC26A2/SLC35D1/SLC22A18	3
GO:0043178	alcohol binding	3/428	89/18367	0.343585306482191	0.566001150972688	ITPR2/CD81/ABCA1	3
GO:0005229	intracellular calcium activated chloride channel activity	1/428	18/18367	0.34597597827314	0.566001150972688	ANO6	1
GO:0008301	DNA binding, bending	1/428	18/18367	0.34597597827314	0.566001150972688	HMGB3	1
GO:0060229	lipase activator activity	1/428	18/18367	0.34597597827314	0.566001150972688	ARF1	1
GO:0061778	intracellular chloride channel activity	1/428	18/18367	0.34597597827314	0.566001150972688	ANO6	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/428	18/18367	0.34597597827314	0.566001150972688	ANXA1	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/428	53/18367	0.351097398817044	0.573091718248448	SLC6A4/SLC5A3	2
GO:0005544	calcium-dependent phospholipid binding	2/428	54/18367	0.359556575704567	0.581806373768384	ANXA4/ANXA1	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/428	19/18367	0.361231429867183	0.581806373768384	GALNT11	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/428	19/18367	0.361231429867183	0.581806373768384	SLC6A4	1
GO:0022840	leak channel activity	1/428	19/18367	0.361231429867183	0.581806373768384	KCNK5	1
GO:0022842	narrow pore channel activity	1/428	19/18367	0.361231429867183	0.581806373768384	KCNK5	1
GO:0035613	RNA stem-loop binding	1/428	19/18367	0.361231429867183	0.581806373768384	EIF4A3	1
GO:0072341	modified amino acid binding	3/428	93/18367	0.369084973341775	0.586686298532745	SCIN/MME/GSTM3	3
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	3/428	94/18367	0.375435245432529	0.586686298532745	AGL/MAN2A1/HEXB	3
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/428	20/18367	0.376131852148459	0.586686298532745	CEBPB	1
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/428	20/18367	0.376131852148459	0.586686298532745	EDF1	1
GO:0001972	retinoic acid binding	1/428	20/18367	0.376131852148459	0.586686298532745	NR2F2	1
GO:0016018	cyclosporin A binding	1/428	20/18367	0.376131852148459	0.586686298532745	PPIA	1
GO:0016408	C-acyltransferase activity	1/428	20/18367	0.376131852148459	0.586686298532745	HADHA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/428	20/18367	0.376131852148459	0.586686298532745	CTSC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/428	20/18367	0.376131852148459	0.586686298532745	MAOA	1
GO:0030296	protein tyrosine kinase activator activity	1/428	20/18367	0.376131852148459	0.586686298532745	CD24	1
GO:0031418	L-ascorbic acid binding	1/428	20/18367	0.376131852148459	0.586686298532745	P3H2	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/428	20/18367	0.376131852148459	0.586686298532745	GNAQ	1
GO:0097001	ceramide binding	1/428	20/18367	0.376131852148459	0.586686298532745	PSAP	1
GO:0042054	histone methyltransferase activity	2/428	56/18367	0.376349589855484	0.586686298532745	SMYD2/SETD7	2
GO:0045309	protein phosphorylated amino acid binding	2/428	56/18367	0.376349589855484	0.586686298532745	RASA1/PFN1	2
GO:0005548	phospholipid transporter activity	2/428	57/18367	0.384678201351451	0.597112431948521	ANO6/ABCA1	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	2/428	57/18367	0.384678201351451	0.597112431948521	P4HB/ERO1B	2
GO:0001848	complement binding	1/428	21/18367	0.390685488562067	0.599516679572483	CD59	1
GO:0005385	zinc ion transmembrane transporter activity	1/428	21/18367	0.390685488562067	0.599516679572483	SLC39A10	1
GO:0008391	arachidonic acid monooxygenase activity	1/428	21/18367	0.390685488562067	0.599516679572483	CYP2J2	1
GO:0051010	microtubule plus-end binding	1/428	21/18367	0.390685488562067	0.599516679572483	DST	1
GO:1990381	ubiquitin-specific protease binding	1/428	21/18367	0.390685488562067	0.599516679572483	CLTC	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	4/428	136/18367	0.391168163182595	0.599516679572483	LDHA/RDH13/HPGD/HADHA	4
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	8/428	299/18367	0.396306176688609	0.605272043275845	ANXA4/CEBPB/NPM1/ACTB/JUND/DNAJA1/GSK3B/GTF2I	8
GO:0016279	protein-lysine N-methyltransferase activity	2/428	59/18367	0.401187637606367	0.605272043275845	SMYD2/SETD7	2
GO:0000062	fatty-acyl-CoA binding	1/428	22/18367	0.404900391587001	0.605272043275845	HADHA	1
GO:0005537	mannose binding	1/428	22/18367	0.404900391587001	0.605272043275845	LMAN1	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/428	22/18367	0.404900391587001	0.605272043275845	RDH13	1
GO:0008320	protein transmembrane transporter activity	1/428	22/18367	0.404900391587001	0.605272043275845	ABCA1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/428	22/18367	0.404900391587001	0.605272043275845	SLC26A2	1
GO:0017075	syntaxin-1 binding	1/428	22/18367	0.404900391587001	0.605272043275845	SLC6A4	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/428	22/18367	0.404900391587001	0.605272043275845	SERPINB9	1
GO:0050321	tau-protein kinase activity	1/428	22/18367	0.404900391587001	0.605272043275845	GSK3B	1
GO:0070034	telomerase RNA binding	1/428	22/18367	0.404900391587001	0.605272043275845	HNRNPC	1
GO:0120020	cholesterol transfer activity	1/428	22/18367	0.404900391587001	0.605272043275845	ABCA1	1
GO:0020037	heme binding	4/428	139/18367	0.406970055053835	0.606959354132454	CYP2J2/CYP11A1/HMOX1/BACH1	4
GO:0001786	phosphatidylserine binding	2/428	60/18367	0.409364069888784	0.606959354132454	SCIN/MME	2
GO:0016278	lysine N-methyltransferase activity	2/428	60/18367	0.409364069888784	0.606959354132454	SMYD2/SETD7	2
GO:0032934	sterol binding	2/428	60/18367	0.409364069888784	0.606959354132454	CD81/ABCA1	2
GO:0005496	steroid binding	3/428	100/18367	0.413218232371085	0.610972070070345	NR3C1/CD81/ABCA1	3
GO:0015179	L-amino acid transmembrane transporter activity	2/428	61/18367	0.417485597116503	0.610972070070345	SLC1A5/SLC38A9	2
GO:0005158	insulin receptor binding	1/428	23/18367	0.418784427149866	0.610972070070345	SORBS1	1
GO:0008143	poly(A) binding	1/428	23/18367	0.418784427149866	0.610972070070345	EIF4A3	1
GO:0015299	solute:proton antiporter activity	1/428	23/18367	0.418784427149866	0.610972070070345	SLC22A18	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/428	23/18367	0.418784427149866	0.610972070070345	CDO1	1
GO:0120015	sterol transfer activity	1/428	23/18367	0.418784427149866	0.610972070070345	ABCA1	1
GO:1901567	fatty acid derivative binding	1/428	23/18367	0.418784427149866	0.610972070070345	HADHA	1
GO:0004497	monooxygenase activity	3/428	102/18367	0.425659493983967	0.618251305703952	CYP2J2/CYP11A1/HMOX1	3
GO:0031490	chromatin DNA binding	3/428	103/18367	0.431845923235848	0.618251305703952	ACTB/HNRNPC/ZFX	3
GO:0000030	mannosyltransferase activity	1/428	24/18367	0.432345278936818	0.618251305703952	TMTC3	1
GO:0003707	steroid hormone receptor activity	1/428	24/18367	0.432345278936818	0.618251305703952	NR3C1	1
GO:0015295	solute:proton symporter activity	1/428	24/18367	0.432345278936818	0.618251305703952	SLC17A5	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/428	24/18367	0.432345278936818	0.618251305703952	CDO1	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/428	24/18367	0.432345278936818	0.618251305703952	GAPDH	1
GO:0043274	phospholipase binding	1/428	24/18367	0.432345278936818	0.618251305703952	SRSF3	1
GO:0050431	transforming growth factor beta binding	1/428	24/18367	0.432345278936818	0.618251305703952	ITGAV	1
GO:0070840	dynein complex binding	1/428	24/18367	0.432345278936818	0.618251305703952	DCTN6	1
GO:0140375	immune receptor activity	4/428	144/18367	0.433115612512384	0.618251305703952	CSF3R/LIFR/CSF2RA/IL6ST	4
GO:0140297	DNA-binding transcription factor binding	10/428	394/18367	0.436958951356751	0.622516862206878	ANXA4/CEBPB/NPM1/ACTB/JUND/DNAJA1/PTMA/GSK3B/GTF2I/RPS3	10
GO:0005112	Notch binding	1/428	25/18367	0.445590452606068	0.628662499025615	GALNT11	1
GO:0005227	calcium activated cation channel activity	1/428	25/18367	0.445590452606068	0.628662499025615	ANO6	1
GO:0030247	polysaccharide binding	1/428	25/18367	0.445590452606068	0.628662499025615	AGL	1
GO:0051019	mitogen-activated protein kinase binding	1/428	25/18367	0.445590452606068	0.628662499025615	DUSP1	1
GO:0120227	acyl-CoA binding	1/428	25/18367	0.445590452606068	0.628662499025615	HADHA	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/428	26/18367	0.458527279903233	0.640052099285044	GLUL	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/428	26/18367	0.458527279903233	0.640052099285044	GLUL	1
GO:0030371	translation repressor activity	1/428	26/18367	0.458527279903233	0.640052099285044	CPEB4	1
GO:0038187	pattern recognition receptor activity	1/428	26/18367	0.458527279903233	0.640052099285044	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/428	26/18367	0.458527279903233	0.640052099285044	SLC26A2	1
GO:0046906	tetrapyrrole binding	4/428	149/18367	0.458938455806034	0.640052099285044	CYP2J2/CYP11A1/HMOX1/BACH1	4
GO:0140677	molecular function activator activity	4/428	150/18367	0.464056398277242	0.642334471371422	PSAP/CALM1/DNAJA1/ARF1	4
GO:0005125	cytokine activity	6/428	235/18367	0.468453470030183	0.642334471371422	MIF/FAM3B/BMP7/GREM2/CMTM8/INHBA	6
GO:0003712	transcription coregulator activity	12/428	489/18367	0.468927502988829	0.642334471371422	NPM1/HSPA1A/MAGED1/PAGE4/CBX4/SUB1/SAP18/BASP1/TBL1X/CREG1/EDF1/MED8	12
GO:0001671	ATPase activator activity	1/428	27/18367	0.471162922681785	0.642334471371422	DNAJA1	1
GO:0004190	aspartic-type endopeptidase activity	1/428	27/18367	0.471162922681785	0.642334471371422	SPPL2A	1
GO:0008139	nuclear localization sequence binding	1/428	27/18367	0.471162922681785	0.642334471371422	TNPO1	1
GO:0016866	intramolecular transferase activity	1/428	27/18367	0.471162922681785	0.642334471371422	CYP2J2	1
GO:0022884	macromolecule transmembrane transporter activity	1/428	27/18367	0.471162922681785	0.642334471371422	ABCA1	1
GO:0048027	mRNA 5'-UTR binding	1/428	27/18367	0.471162922681785	0.642334471371422	IGF2BP3	1
GO:0051393	alpha-actinin binding	1/428	27/18367	0.471162922681785	0.642334471371422	DAG1	1
GO:0051959	dynein light intermediate chain binding	1/428	27/18367	0.471162922681785	0.642334471371422	DYNLL1	1
GO:0070006	metalloaminopeptidase activity	1/428	27/18367	0.471162922681785	0.642334471371422	LNPEP	1
GO:0008047	enzyme activator activity	3/428	110/18367	0.474412405865958	0.645555572841901	PSAP/CALM1/ARF1	3
GO:0017171	serine hydrolase activity	5/428	195/18367	0.477971668318911	0.649185400254044	HTRA4/DPP7/DPP4/CTSC/NCEH1	5
GO:0032182	ubiquitin-like protein binding	3/428	111/18367	0.480376145541474	0.650630658655809	CBX4/USP25/N4BP2	3
GO:0017056	structural constituent of nuclear pore	1/428	28/18367	0.483504376830759	0.650630658655809	NUTF2	1
GO:0046875	ephrin receptor binding	1/428	28/18367	0.483504376830759	0.650630658655809	SDCBP	1
GO:0051861	glycolipid binding	1/428	28/18367	0.483504376830759	0.650630658655809	PSAP	1
GO:0070001	aspartic-type peptidase activity	1/428	28/18367	0.483504376830759	0.650630658655809	SPPL2A	1
GO:0001098	basal transcription machinery binding	2/428	70/18367	0.487834643639084	0.651203196045933	SMYD2/EDF1	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/428	70/18367	0.487834643639084	0.651203196045933	SMYD2/EDF1	2
GO:0004860	protein kinase inhibitor activity	2/428	70/18367	0.487834643639084	0.651203196045933	NPM1/PKIB	2
GO:0060090	molecular adaptor activity	9/428	369/18367	0.492193841367341	0.651203196045933	GAS2L3/PDCD6/AKAP9/CUX1/SORBS1/SYNE2/SDCBP/HERPUD1/PDE4DIP	9
GO:0031491	nucleosome binding	2/428	71/18367	0.495321501945307	0.651203196045933	ACTB/HNRNPC	2
GO:0004033	aldo-keto reductase (NADP) activity	1/428	29/18367	0.495558476111878	0.651203196045933	RDH13	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/428	29/18367	0.495558476111878	0.651203196045933	CDK6	1
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/428	29/18367	0.495558476111878	0.651203196045933	P2RX4	1
GO:0015301	anion:anion antiporter activity	1/428	29/18367	0.495558476111878	0.651203196045933	SLC26A2	1
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	1/428	29/18367	0.495558476111878	0.651203196045933	TTPA	1
GO:0046625	sphingolipid binding	1/428	29/18367	0.495558476111878	0.651203196045933	PSAP	1
GO:0070717	poly-purine tract binding	1/428	29/18367	0.495558476111878	0.651203196045933	EIF4A3	1
GO:0097472	cyclin-dependent protein kinase activity	1/428	29/18367	0.495558476111878	0.651203196045933	CDK6	1
GO:0008235	metalloexopeptidase activity	2/428	72/18367	0.502738502705181	0.656080842131979	TFRC/LNPEP	2
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	2/428	72/18367	0.502738502705181	0.656080842131979	COX7A2L/COX6A1	2
GO:0030276	clathrin binding	2/428	72/18367	0.502738502705181	0.656080842131979	CLTC/LRP1	2
GO:0005244	voltage-gated ion channel activity	5/428	201/18367	0.504575026514787	0.656080842131979	TMEM37/ANO6/CLIC3/ITGAV/KCNK5	5
GO:0022832	voltage-gated channel activity	5/428	201/18367	0.504575026514787	0.656080842131979	TMEM37/ANO6/CLIC3/ITGAV/KCNK5	5
GO:0042393	histone binding	6/428	244/18367	0.50475195794853	0.656080842131979	MORC4/NPM1/CBX4/TBL1X/MPHOSPH8/KMT2E	6
GO:0005217	intracellular ligand-gated ion channel activity	1/428	30/18367	0.507331895908154	0.656080842131979	ITPR2	1
GO:0016417	S-acyltransferase activity	1/428	30/18367	0.507331895908154	0.656080842131979	GLUL	1
GO:0033293	monocarboxylic acid binding	2/428	73/18367	0.510084830558654	0.656080842131979	PSAP/NR2F2	2
GO:0106306	protein serine phosphatase activity	2/428	73/18367	0.510084830558654	0.656080842131979	DUSP1/DUSP5	2
GO:0106307	protein threonine phosphatase activity	2/428	73/18367	0.510084830558654	0.656080842131979	DUSP1/DUSP5	2
GO:0140104	molecular carrier activity	2/428	73/18367	0.510084830558654	0.656080842131979	TNPO1/NUTF2	2
GO:0005254	chloride channel activity	2/428	74/18367	0.517359745819476	0.659178153949441	ANO6/CLIC3	2
GO:0017022	myosin binding	2/428	74/18367	0.517359745819476	0.659178153949441	HAP1/MYL12B	2
GO:0019210	kinase inhibitor activity	2/428	74/18367	0.517359745819476	0.659178153949441	NPM1/PKIB	2
GO:0019905	syntaxin binding	2/428	74/18367	0.517359745819476	0.659178153949441	SLC6A4/ABCA1	2
GO:0019887	protein kinase regulator activity	5/428	204/18367	0.517677265402985	0.659178153949441	NPM1/CALM1/CD24/HSP90AB1/PKIB	5
GO:0008157	protein phosphatase 1 binding	1/428	31/18367	0.51883115688603	0.659178153949441	PPP1R15A	1
GO:0031210	phosphatidylcholine binding	1/428	31/18367	0.51883115688603	0.659178153949441	ABCA1	1
GO:0008083	growth factor activity	4/428	162/18367	0.52396704817925	0.664543573300512	EFEMP1/BMP7/INHBA/PGF	4
GO:0004197	cysteine-type endopeptidase activity	3/428	119/18367	0.526872179443658	0.667065994147796	LGMN/CTSC/USP25	3
GO:0003924	GTPase activity	8/428	337/18367	0.528872743640258	0.667622134258069	EEF1A1/GNAQ/RAB1A/RHOB/RAB2A/RASA1/ARHGAP5/ARF1	8
GO:0030332	cyclin binding	1/428	32/18367	0.530062628573027	0.667622134258069	CDK6	1
GO:0071889	14-3-3 protein binding	1/428	32/18367	0.530062628573027	0.667622134258069	TMCC3	1
GO:0030674	protein-macromolecule adaptor activity	7/428	296/18367	0.53760820070351	0.675325225352788	GAS2L3/PDCD6/CUX1/SORBS1/SYNE2/SDCBP/HERPUD1	7
GO:0016874	ligase activity	4/428	165/18367	0.538445680660635	0.675325225352788	SLC27A2/GLUL/UBA5/ACSL3	4
GO:0022836	gated channel activity	8/428	340/18367	0.538961477925783	0.675325225352788	TMEM37/ANO6/CLIC3/ITPR2/ITGAV/P2RX4/TMEM150C/KCNK5	8
GO:0140323	solute:anion antiporter activity	1/428	33/18367	0.54103253285286	0.676755470647564	SLC26A2	1
GO:0015020	glucuronosyltransferase activity	1/428	34/18367	0.551746947379913	0.685446719611905	CHPF	1
GO:0016831	carboxy-lyase activity	1/428	34/18367	0.551746947379913	0.685446719611905	UMPS	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/428	34/18367	0.551746947379913	0.685446719611905	PKIB	1
GO:0045505	dynein intermediate chain binding	1/428	34/18367	0.551746947379913	0.685446719611905	DYNLL1	1
GO:0015298	solute:cation antiporter activity	1/428	35/18367	0.562211808914926	0.697257575621919	SLC22A18	1
GO:0015267	channel activity	11/428	480/18367	0.565503877095612	0.699083064756306	LRRC8D/GJA1/TMEM37/ANO6/CLIC3/GJA5/ITPR2/ITGAV/P2RX4/TMEM150C/KCNK5	11
GO:0009055	electron transfer activity	3/428	126/18367	0.565604292776736	0.699083064756306	ASPH/COX7A2L/COX6A1	3
GO:0022803	passive transmembrane transporter activity	11/428	481/18367	0.568296142869811	0.701219647473259	LRRC8D/GJA1/TMEM37/ANO6/CLIC3/GJA5/ITPR2/ITGAV/P2RX4/TMEM150C/KCNK5	11
GO:0015248	sterol transporter activity	1/428	36/18367	0.572432916583724	0.702750696918974	ABCA1	1
GO:0034061	DNA polymerase activity	1/428	36/18367	0.572432916583724	0.702750696918974	PTGES3	1
GO:0042805	actinin binding	1/428	36/18367	0.572432916583724	0.702750696918974	DAG1	1
GO:1901981	phosphatidylinositol phosphate binding	4/428	173/18367	0.575927430527298	0.705850453575544	SCIN/TTPA/PFN1/SDCBP	4
GO:0004721	phosphoprotein phosphatase activity	4/428	174/18367	0.580490735559597	0.706664667873697	DUSP1/PTPRF/DUSP5/UBASH3B	4
GO:0016298	lipase activity	3/428	129/18367	0.581599856180469	0.706664667873697	LIPA/NCEH1/HMOX1	3
GO:0016409	palmitoyltransferase activity	1/428	37/18367	0.58241593506074	0.706664667873697	GLUL	1
GO:0046915	transition metal ion transmembrane transporter activity	1/428	37/18367	0.58241593506074	0.706664667873697	SLC39A10	1
GO:0071855	neuropeptide receptor binding	1/428	37/18367	0.58241593506074	0.706664667873697	APELA	1
GO:0071949	FAD binding	1/428	37/18367	0.58241593506074	0.706664667873697	ERO1B	1
GO:0015171	amino acid transmembrane transporter activity	2/428	84/18367	0.586066731884355	0.708307007269036	SLC1A5/SLC38A9	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7/428	310/18367	0.586647427843006	0.708307007269036	CEBPB/ATF3/NR3C1/ENO1/NFE2L3/ZFHX3/BACH1	7
GO:0017124	SH3 domain binding	3/428	130/18367	0.586848336039813	0.708307007269036	GJA1/LRP2/SH3BGRL2	3
GO:0031406	carboxylic acid binding	4/428	176/18367	0.589532585602947	0.708307007269036	PSAP/GLUL/P3H2/NR2F2	4
GO:0004520	endodeoxyribonuclease activity	1/428	38/18367	0.592166397679071	0.708307007269036	RPS3	1
GO:0005501	retinoid binding	1/428	38/18367	0.592166397679071	0.708307007269036	NR2F2	1
GO:0019840	isoprenoid binding	1/428	38/18367	0.592166397679071	0.708307007269036	NR2F2	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/428	38/18367	0.592166397679071	0.708307007269036	RPS3	1
GO:0050660	flavin adenine dinucleotide binding	2/428	85/18367	0.592526054157751	0.708307007269036	MAOA/ERO1B	2
GO:0001217	DNA-binding transcription repressor activity	7/428	313/18367	0.596820616792066	0.711579329428586	CEBPB/ATF3/NR3C1/ENO1/NFE2L3/ZFHX3/BACH1	7
GO:0016779	nucleotidyltransferase activity	3/428	132/18367	0.597218365770421	0.711579329428586	UGP2/PTGES3/CDS1	3
GO:0050997	quaternary ammonium group binding	1/428	39/18367	0.601689709468768	0.71573547139422	ABCA1	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	10/428	450/18367	0.605480717680891	0.719070085598187	CEBPB/TFDP2/JUND/ATF3/NR3C1/JUNB/ZFAT/GTF2I/EGR1/BACH1	10
GO:0016887	ATP hydrolysis activity	6/428	272/18367	0.610901663382482	0.720286039984685	ATP2B1/HSPA1A/ATP10D/ATP2B4/EIF4A3/HSPA1B	6
GO:0003925	G protein activity	1/428	40/18367	0.610991150124997	0.720286039984685	RAB1A	1
GO:0042287	MHC protein binding	1/428	40/18367	0.610991150124997	0.720286039984685	CD81	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/428	40/18367	0.610991150124997	0.720286039984685	SERPINB9	1
GO:0008276	protein methyltransferase activity	2/428	88/18367	0.61145161086612	0.720286039984685	SMYD2/SETD7	2
GO:0043177	organic acid binding	3/428	135/18367	0.612452163247296	0.720299151605866	GLUL/P3H2/NR2F2	3
GO:0001216	DNA-binding transcription activator activity	10/428	456/18367	0.622143539087356	0.730516929767089	CEBPB/TFDP2/JUND/ATF3/NR3C1/JUNB/ZFAT/GTF2I/EGR1/BACH1	10
GO:0019205	nucleobase-containing compound kinase activity	1/428	42/18367	0.628948927474294	0.736133149841296	N4BP2	1
GO:0019894	kinesin binding	1/428	42/18367	0.628948927474294	0.736133149841296	ACTB	1
GO:0019207	kinase regulator activity	5/428	233/18367	0.635515331893908	0.741571351825515	NPM1/CALM1/CD24/HSP90AB1/PKIB	5
GO:0043130	ubiquitin binding	2/428	92/18367	0.635632587279013	0.741571351825515	USP25/N4BP2	2
GO:0030547	signaling receptor inhibitor activity	1/428	43/18367	0.637615222647064	0.7426942113393	LY6E	1
GO:0046982	protein heterodimerization activity	7/428	328/18367	0.645682478265139	0.748958481396267	ITGB1/ADRB1/CEBPB/TENM3/P4HB/ATF3/SDCBP	7
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/428	44/18367	0.64607956911656	0.748958481396267	SGK1	1
GO:0022839	ion gated channel activity	1/428	44/18367	0.64607956911656	0.748958481396267	ANO6	1
GO:0005543	phospholipid binding	10/428	466/18367	0.649097611512675	0.749355412939126	SCIN/ANXA4/ANXA1/MME/PSAP/ITPR2/TTPA/ABCA1/PFN1/SDCBP	10
GO:0008234	cysteine-type peptidase activity	4/428	190/18367	0.649509980171138	0.749355412939126	LGMN/CTSC/USP25/USP27X	4
GO:0008237	metallopeptidase activity	4/428	190/18367	0.649509980171138	0.749355412939126	ADAMTS6/MME/TFRC/LNPEP	4
GO:0008236	serine-type peptidase activity	4/428	191/18367	0.653564149950404	0.751839250440317	HTRA4/DPP7/DPP4/CTSC	4
GO:0005245	voltage-gated calcium channel activity	1/428	45/18367	0.654346662082675	0.751839250440317	ITGAV	1
GO:0005525	GTP binding	8/428	377/18367	0.655191608664426	0.751839250440317	EEF1A1/HSP90AB1/GNAQ/RAB1A/RHOB/RAB2A/ARHGAP5/ARF1	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3/428	144/18367	0.655793851689012	0.751839250440317	AGL/MAN2A1/HEXB	3
GO:0140296	general transcription initiation factor binding	1/428	46/18367	0.6624210878347	0.758243006200726	EDF1	1
GO:0008170	N-methyltransferase activity	2/428	97/18367	0.664182700775209	0.759065943743095	SMYD2/SETD7	2
GO:0004722	protein serine/threonine phosphatase activity	2/428	98/18367	0.669672055797672	0.762474583634213	DUSP1/DUSP5	2
GO:0035254	glutamate receptor binding	1/428	47/18367	0.670307326271835	0.762474583634213	CALM1	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/428	47/18367	0.670307326271835	0.762474583634213	ADRB1	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/428	48/18367	0.678009753365485	0.770032918018834	GLUL	1
GO:0005216	ion channel activity	9/428	432/18367	0.680087105704671	0.771189116749222	LRRC8D/TMEM37/ANO6/CLIC3/ITPR2/ITGAV/P2RX4/TMEM150C/KCNK5	9
GO:0043539	protein serine/threonine kinase activator activity	1/428	49/18367	0.685532643564708	0.775145191085412	CALM1	1
GO:0030295	protein kinase activator activity	2/428	101/18367	0.685705361344787	0.775145191085412	CALM1/CD24	2
GO:0000993	RNA polymerase II complex binding	1/428	50/18367	0.69288017214612	0.777221518216295	SMYD2	1
GO:0005048	signal sequence binding	1/428	50/18367	0.69288017214612	0.777221518216295	TNPO1	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/428	50/18367	0.69288017214612	0.777221518216295	MAN2A1	1
GO:0030159	signaling receptor complex adaptor activity	1/428	50/18367	0.69288017214612	0.777221518216295	SORBS1	1
GO:0140359	ABC-type transporter activity	1/428	50/18367	0.69288017214612	0.777221518216295	ABCA1	1
GO:0008227	G protein-coupled amine receptor activity	1/428	51/18367	0.700056417509523	0.784063187610666	ADRB1	1
GO:1990782	protein tyrosine kinase binding	2/428	105/18367	0.70608489739708	0.785868068046019	ITGB1/FNTA	2
GO:0008146	sulfotransferase activity	1/428	52/18367	0.707065363420526	0.785868068046019	HS6ST2	1
GO:0016597	amino acid binding	1/428	52/18367	0.707065363420526	0.785868068046019	GLUL	1
GO:0017046	peptide hormone binding	1/428	52/18367	0.707065363420526	0.785868068046019	INHBA	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/428	52/18367	0.707065363420526	0.785868068046019	AGL	1
GO:0019001	guanyl nucleotide binding	8/428	398/18367	0.712933256906985	0.788660297533523	EEF1A1/HSP90AB1/GNAQ/RAB1A/RHOB/RAB2A/ARHGAP5/ARF1	8
GO:0032561	guanyl ribonucleotide binding	8/428	398/18367	0.712933256906985	0.788660297533523	EEF1A1/HSP90AB1/GNAQ/RAB1A/RHOB/RAB2A/ARHGAP5/ARF1	8
GO:0017069	snRNA binding	1/428	53/18367	0.713910901201362	0.788660297533523	EIF5A	1
GO:0050661	NADP binding	1/428	53/18367	0.713910901201362	0.788660297533523	GAPDH	1
GO:0019209	kinase activator activity	2/428	107/18367	0.715855496087689	0.789610304775512	CALM1/CD24	2
GO:0000149	SNARE binding	2/428	110/18367	0.729999249189646	0.803993121649111	SLC6A4/ABCA1	2
GO:0003713	transcription coactivator activity	5/428	262/18367	0.733940727182272	0.806597086645475	NPM1/MAGED1/PAGE4/SUB1/EDF1	5
GO:0004222	metalloendopeptidase activity	2/428	111/18367	0.734579489623557	0.806597086645475	ADAMTS6/MME	2
GO:0004536	deoxyribonuclease activity	1/428	57/18367	0.739733680426878	0.809813713309425	RPS3	1
GO:0043175	RNA polymerase core enzyme binding	1/428	57/18367	0.739733680426878	0.809813713309425	SMYD2	1
GO:0004843	thiol-dependent deubiquitinase	2/428	113/18367	0.743541924625157	0.811542010685329	USP25/USP27X	2
GO:0099094	ligand-gated cation channel activity	2/428	113/18367	0.743541924625157	0.811542010685329	ITPR2/P2RX4	2
GO:0003774	cytoskeletal motor activity	2/428	114/18367	0.747925308217595	0.813885836147099	MYL6/MYO5B	2
GO:0101005	deubiquitinase activity	2/428	114/18367	0.747925308217595	0.813885836147099	USP25/USP27X	2
GO:0036002	pre-mRNA binding	1/428	59/18367	0.751759352422494	0.81683702770683	HNRNPA1	1
GO:0005126	cytokine receptor binding	5/428	271/18367	0.760223258100067	0.823575196275073	MIF/LIFR/PGF/IL6ST/SDCBP	5
GO:0035091	phosphatidylinositol binding	5/428	271/18367	0.760223258100067	0.823575196275073	SCIN/ITPR2/TTPA/PFN1/SDCBP	5
GO:0043621	protein self-association	1/428	61/18367	0.763230613382271	0.825604586244121	CTSC	1
GO:0098960	postsynaptic neurotransmitter receptor activity	1/428	62/18367	0.768766355623743	0.8291287509542	ADRB1	1
GO:1990841	promoter-specific chromatin binding	1/428	62/18367	0.768766355623743	0.8291287509542	EGR1	1
GO:0016791	phosphatase activity	5/428	275/18367	0.771261004039461	0.830588773580957	DUSP1/PTPRF/DUSP5/PLPP3/UBASH3B	5
GO:0004252	serine-type endopeptidase activity	3/428	174/18367	0.77462701184018	0.832981483928584	HTRA4/DPP4/CTSC	3
GO:0140097	catalytic activity, acting on DNA	4/428	229/18367	0.784179077789679	0.842009393260894	ANXA1/PTGES3/TOP1/RPS3	4
GO:0004175	endopeptidase activity	8/428	430/18367	0.787962706093185	0.844825994161766	ADAMTS6/LGMN/HTRA4/MME/DPP4/CTSC/SPPL2A/USP25	8
GO:0019783	ubiquitin-like protein-specific protease activity	2/428	125/18367	0.79202874385953	0.847936655190791	USP25/USP27X	2
GO:0008242	omega peptidase activity	2/428	126/18367	0.795680751135059	0.848312946916112	USP25/USP27X	2
GO:0005261	cation channel activity	6/428	335/18367	0.796153181085503	0.848312946916112	TMEM37/ANO6/ITPR2/ITGAV/P2RX4/KCNK5	6
GO:0004674	protein serine/threonine kinase activity	7/428	386/18367	0.798850955730135	0.848312946916112	EGFR/SGK1/CDK6/TOP1/MAP3K4/GSK3B/RPS6KA5	7
GO:0003684	damaged DNA binding	1/428	68/18367	0.79937181536326	0.848312946916112	RPS3	1
GO:0051536	iron-sulfur cluster binding	1/428	68/18367	0.79937181536326	0.848312946916112	RPS3	1
GO:0051540	metal cluster binding	1/428	68/18367	0.79937181536326	0.848312946916112	RPS3	1
GO:0004519	endonuclease activity	2/428	129/18367	0.806298860111726	0.854418588298889	N4BP2/RPS3	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/428	71/18367	0.813123482981965	0.860398104085568	ASAH1	1
GO:0000049	tRNA binding	1/428	72/18367	0.817495102422483	0.862516571831257	EEF1A1	1
GO:0003678	DNA helicase activity	1/428	72/18367	0.817495102422483	0.862516571831257	ANXA1	1
GO:0005230	extracellular ligand-gated ion channel activity	1/428	73/18367	0.821764689531703	0.864515453726994	P2RX4	1
GO:0070063	RNA polymerase binding	1/428	73/18367	0.821764689531703	0.864515453726994	SMYD2	1
GO:0003724	RNA helicase activity	1/428	77/18367	0.837869413453418	0.880186050496521	EIF4A3	1
GO:0019787	ubiquitin-like protein transferase activity	8/428	458/18367	0.840844804209111	0.880360560787913	CBX4/BIRC6/RNF128/UBE2I/RNF43/NEURL1/UBE2B/NHLRC3	8
GO:0001221	transcription coregulator binding	1/428	78/18367	0.841663393280752	0.880360560787913	UBE2I	1
GO:0030971	receptor tyrosine kinase binding	1/428	78/18367	0.841663393280752	0.880360560787913	FNTA	1
GO:0008186	ATP-dependent activity, acting on RNA	1/428	79/18367	0.845368793667643	0.882967692668643	EIF4A3	1
GO:0015276	ligand-gated ion channel activity	2/428	143/18367	0.84961365317892	0.884862288289347	ITPR2/P2RX4	2
GO:0022834	ligand-gated channel activity	2/428	143/18367	0.84961365317892	0.884862288289347	ITPR2/P2RX4	2
GO:0016922	nuclear receptor binding	2/428	144/18367	0.852343509537933	0.885358146744001	CEBPB/JUND	2
GO:0035591	signaling adaptor activity	1/428	81/18367	0.852522061631243	0.885358146744001	SORBS1	1
GO:0042578	phosphoric ester hydrolase activity	6/428	366/18367	0.858246091915844	0.889591706251767	DUSP1/PTPRF/DUSP5/HMOX1/PLPP3/UBASH3B	6
GO:0008528	G protein-coupled peptide receptor activity	2/428	147/18367	0.860264507144566	0.889591706251767	LGR5/LGR4	2
GO:0052689	carboxylic ester hydrolase activity	2/428	147/18367	0.860264507144566	0.889591706251767	LIPA/NCEH1	2
GO:0019842	vitamin binding	2/428	148/18367	0.862817357576661	0.889871605496222	TTPA/P3H2	2
GO:0061659	ubiquitin-like protein ligase activity	5/428	316/18367	0.862979881154303	0.889871605496222	CBX4/RNF128/RNF43/NEURL1/NHLRC3	5
GO:0001653	peptide receptor activity	2/428	153/18367	0.874952561663215	0.900941251613608	LGR5/LGR4	2
GO:0008081	phosphoric diester hydrolase activity	1/428	89/18367	0.87798198909436	0.90278374019872	HMOX1	1
GO:0004386	helicase activity	2/428	156/18367	0.881751591235647	0.904105856928945	ANXA1/EIF4A3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/428	156/18367	0.881751591235647	0.904105856928945	SMYD2/SETD7	2
GO:0016407	acetyltransferase activity	1/428	91/18367	0.883629616334252	0.904757188032821	HADHA	1
GO:0005085	guanyl-nucleotide exchange factor activity	3/428	223/18367	0.895184320511385	0.91530082209591	ADRB1/C9orf72/EPS8L1	3
GO:0004620	phospholipase activity	1/428	104/18367	0.914491891376549	0.933730851223181	HMOX1	1
GO:0106310	protein serine kinase activity	5/428	360/18367	0.924973643483774	0.941803246942759	SGK1/CDK6/MAP3K4/GSK3B/RPS6KA5	5
GO:0061630	ubiquitin protein ligase activity	4/428	304/18367	0.92653534015225	0.941803246942759	RNF128/RNF43/NEURL1/NHLRC3	4
GO:0008094	ATP-dependent activity, acting on DNA	1/428	111/18367	0.927572703376317	0.941803246942759	ANXA1	1
GO:0030594	neurotransmitter receptor activity	1/428	111/18367	0.927572703376317	0.941803246942759	ADRB1	1
GO:0004842	ubiquitin-protein transferase activity	6/428	433/18367	0.940526316062177	0.95362556837502	BIRC6/RNF128/RNF43/NEURL1/UBE2B/NHLRC3	6
GO:0005267	potassium channel activity	1/428	121/18367	0.942872324954034	0.954674621093931	KCNK5	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/428	125/18367	0.948047284187864	0.958581142901062	ASAH1	1
GO:0004518	nuclease activity	2/428	210/18367	0.958287288152127	0.967591048231274	N4BP2/RPS3	2
GO:0008168	methyltransferase activity	2/428	214/18367	0.961473231541239	0.969463313797814	SMYD2/SETD7	2
GO:0022843	voltage-gated cation channel activity	1/428	143/18367	0.966121621063344	0.97250302766526	ITGAV	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	2/428	222/18367	0.96715960443633	0.97250302766526	GLUL/HADHA	2
GO:0016741	transferase activity, transferring one-carbon groups	2/428	225/18367	0.969076624208569	0.973086596446674	SMYD2/SETD7	2
GO:0015079	potassium ion transmembrane transporter activity	1/428	155/18367	0.974529993135391	0.977214648763863	KCNK5	1
GO:0016746	acyltransferase activity	2/428	250/18367	0.981362694628483	0.982712574538563	GLUL/HADHA	2
GO:0140098	catalytic activity, acting on RNA	1/428	386/18367	0.999898879443443	0.999898879443443	EIF4A3	1