ID Description GeneRatio BgRatio pvalue p.adjust geneID geneName Count hsa03010 Ribosome 40/494 91/5868 4.31798689256068e-20 8.16099522693968e-18 6147/6122/6157/23521/6138/6189/6204/6133/6128/6175/6160/6224/6205/6129/9349/6173/6194/6125/6187/6202/6217/6130/9045/6170/6188/6218/6139/6191/6154/6152/6227/6230/6207/3921/4736/6169/6203/11224/6155/6124 RPL23A/RPL3/RPL27A/RPL13A/RPL15/RPS3A/RPS10/RPL9/RPL6/RPLP0/RPL31/RPS20/RPS11/RPL7/RPL23/RPL36A/RPS6/RPL5/RPS2/RPS8/RPS16/RPL7A/RPL14/RPL39/RPS3/RPS17/RPL17/RPS4X/RPL26/RPL24/RPS21/RPS25/RPS13/RPSA/RPL10A/RPL38/RPS9/RPL35/RPL27/RPL4 40 hsa04142 Lysosome 35/494 121/5868 2.60913321142925e-11 2.46563088480064e-09 5660/2799/5641/427/2548/1075/2720/1508/1509/3074/26503/3988/1213/4126/3073/4891/2760/950/537/79158/8722/3920/4864/1203/2990/1200/6609/138050/1519/2517/4669/5476/1211/1201/535 PSAP/GNS/LGMN/ASAH1/GAA/CTSC/GLB1/CTSB/CTSD/HEXB/SLC17A5/LIPA/CLTC/MANBA/HEXA/SLC11A2/GM2A/SCARB2/ATP6AP1/GNPTAB/CTSF/LAMP2/NPC1/CLN5/GUSB/TPP1/SMPD1/HGSNAT/CTSO/FUCA1/NAGLU/CTSA/CLTA/CLN3/ATP6V0A1 35 hsa04141 Protein processing in endoplasmic reticulum 39/494 165/5868 1.44025027339616e-09 9.07357672239581e-08 6238/3998/23193/821/7184/7095/6185/10970/80267/201595/3326/6400/22926/27248/7841/11231/29927/10905/7991/5034/3309/2923/22872/3703/267/23471/6745/6184/5611/57134/64374/9601/56605/10277/6500/3301/11253/3303/7466 RRBP1/LMAN1/GANAB/CANX/HSP90B1/SEC62/RPN2/CKAP4/EDEM3/STT3B/HSP90AB1/SEL1L/ATF6/ERLEC1/MOGS/SEC63/SEC61A1/MAN1A2/TUSC3/P4HB/HSPA5/PDIA3/SEC31A/STT3A/AMFR/TRAM1/SSR1/RPN1/DNAJC3/MAN1C1/SIL1/PDIA4/ERO1B/UBE4B/SKP1/DNAJA1/MAN1B1/HSPA1A/WFS1 39 hsa04520 Adherens junction 23/494 73/5868 1.21020758397356e-08 5.71823083427507e-07 1956/999/4233/5792/8826/3480/71/1500/4008/81/7046/6934/10580/5797/8976/4087/60/3643/1387/2064/1499/387/10163 EGFR/CDH1/MET/PTPRF/IQGAP1/IGF1R/ACTG1/CTNND1/LMO7/ACTN4/TGFBR1/TCF7L2/SORBS1/PTPRM/WASL/SMAD2/ACTB/INSR/CREBBP/ERBB2/CTNNB1/RHOA/WASF2 23 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/494 74/5868 1.73195785747687e-06 6.54680070126255e-05 3655/1605/3688/3691/3685/1824/3696/3693/71/2697/1829/488/81/6934/1756/1832/5318/60/3694/1499 ITGA6/DAG1/ITGB1/ITGB4/ITGAV/DSC2/ITGB8/ITGB5/ACTG1/GJA1/DSG2/ATP2A2/ACTN4/TCF7L2/DMD/DSP/PKP2/ACTB/ITGB6/CTNNB1 20 hsa00510 N-Glycan biosynthesis 15/494 49/5868 6.54499552159292e-06 0.000206167358930177 23193/6185/201595/2683/7841/4124/10905/7991/3703/6184/57134/85365/144245/4245/11253 GANAB/RPN2/STT3B/B4GALT1/MOGS/MAN2A1/MAN1A2/TUSC3/STT3A/RPN1/MAN1C1/ALG2/ALG10B/MGAT1/MAN1B1 15 hsa04510 Focal adhesion 35/494 200/5868 1.98389961510822e-05 0.000535652896079218 1956/3655/3911/1284/3915/3912/4233/3688/3691/3685/2321/3480/3696/394/3693/71/1282/103910/10627/81/2335/1290/6093/4659/10451/10000/80310/857/595/331/60/3694/2064/1499/387 EGFR/ITGA6/LAMA5/COL4A2/LAMC1/LAMB1/MET/ITGB1/ITGB4/ITGAV/FLT1/IGF1R/ITGB8/ARHGAP5/ITGB5/ACTG1/COL4A1/MYL12B/MYL12A/ACTN4/FN1/COL5A2/ROCK1/PPP1R12A/VAV3/AKT3/PDGFD/CAV1/CCND1/XIAP/ACTB/ITGB6/ERBB2/CTNNB1/RHOA 35 hsa04810 Regulation of actin cytoskeleton 36/494 213/5868 3.30313873312417e-05 0.000780366525700586 1956/3655/3688/3691/5216/3685/10788/8826/3696/3693/71/1730/1072/85477/103910/10627/2768/6548/81/2335/6093/10787/4659/4628/7114/8976/10451/10094/80310/60/3694/10152/2263/26999/387/10163 EGFR/ITGA6/ITGB1/ITGB4/PFN1/ITGAV/IQGAP2/IQGAP1/ITGB8/ITGB5/ACTG1/DIAPH2/CFL1/SCIN/MYL12B/MYL12A/GNA12/SLC9A1/ACTN4/FN1/ROCK1/NCKAP1/PPP1R12A/MYH10/TMSB4X/WASL/VAV3/ARPC3/PDGFD/ACTB/ITGB6/ABI2/FGFR2/CYFIP2/RHOA/WASF2 36 hsa05100 Bacterial invasion of epithelial cells 15/494 70/5868 0.000571304543197893 0.00930005237309589 999/4233/3688/71/1213/2335/2549/8976/1211/10094/857/60/1499/387/10163 CDH1/MET/ITGB1/ACTG1/CLTC/FN1/GAB1/WASL/CLTA/ARPC3/CAV1/ACTB/CTNNB1/RHOA/WASF2 15 hsa04512 ECM-receptor interaction 17/494 85/5868 0.000587786988915201 0.00930005237309589 3655/3911/1284/3915/1605/3912/3688/3691/3685/3696/3693/1282/2335/1290/961/3694/3161 ITGA6/LAMA5/COL4A2/LAMC1/DAG1/LAMB1/ITGB1/ITGB4/ITGAV/ITGB8/ITGB5/COL4A1/FN1/COL5A2/CD47/ITGB6/HMMR 17 hsa05222 Small cell lung cancer 17/494 85/5868 0.000587786988915201 0.00930005237309589 3655/3911/1284/3915/3912/3688/3685/1021/1282/2335/6502/8554/10000/595/331/1163/54205 ITGA6/LAMA5/COL4A2/LAMC1/LAMB1/ITGB1/ITGAV/CDK6/COL4A1/FN1/SKP2/PIAS1/AKT3/CCND1/XIAP/CKS1B/CYCS 17 hsa00531 Glycosaminoglycan degradation 7/494 19/5868 0.00059047951575212 0.00930005237309589 2799/2720/3074/3073/2990/138050/4669 GNS/GLB1/HEXB/HEXA/GUSB/HGSNAT/NAGLU 7 hsa05130 Pathogenic Escherichia coli infection 12/494 56/5868 0.00199663807868685 0.0290280459132166 999/3688/71/3875/6093/8976/10094/60/4691/100506658/1499/387 CDH1/ITGB1/ACTG1/KRT18/ROCK1/WASL/ARPC3/ACTB/NCL/OCLN/CTNNB1/RHOA 12 hsa04360 Axon guidance 21/494 129/5868 0.00234408951475754 0.0316452084492269 4233/3688/80031/8829/57556/1072/5364/6405/10725/23654/5921/5361/6093/10509/2050/8482/4775/1946/5530/57522/387 MET/ITGB1/SEMA6D/NRP1/SEMA6A/CFL1/PLXNB1/SEMA3F/NFAT5/PLXNB2/RASA1/PLXNA1/ROCK1/SEMA4B/EPHB4/SEMA7A/NFATC3/EFNA5/PPP3CA/SRGAP1/RHOA 21 hsa05200 Pathways in cancer 42/494 326/5868 0.00312651613710314 0.0393941033274995 1956/1441/3655/3911/1284/3915/999/3912/4233/3688/6513/3685/1021/3480/7184/1282/7175/3326/2335/2950/7046/6934/7855/1857/6502/2737/8554/4087/10000/8323/595/26060/331/2263/7976/1163/1387/2064/54205/1499/332/387 EGFR/CSF3R/ITGA6/LAMA5/COL4A2/LAMC1/CDH1/LAMB1/MET/ITGB1/SLC2A1/ITGAV/CDK6/IGF1R/HSP90B1/COL4A1/TPR/HSP90AB1/FN1/GSTP1/TGFBR1/TCF7L2/FZD5/DVL3/SKP2/GLI3/PIAS1/SMAD2/AKT3/FZD6/CCND1/APPL1/XIAP/FGFR2/FZD3/CKS1B/CREBBP/ERBB2/CYCS/CTNNB1/BIRC5/RHOA 42 hsa04120 Ubiquitin mediated proteolysis 21/494 135/5868 0.00410259631864944 0.0484619190140465 51366/57448/1642/11059/26091/7332/9320/6502/8554/7317/9354/9886/331/7328/10277/6500/55236/8924/64750/11065/991 UBR5/BIRC6/DDB1/WWP1/HERC4/UBE2L3/TRIP12/SKP2/PIAS1/UBA1/UBE4A/RHOBTB1/XIAP/UBE2H/UBE4B/SKP1/UBA6/HERC2/SMURF2/UBE2C/CDC20 21 hsa00511 Other glycan degradation 5/494 17/5868 0.0109328065927706 0.121547085060803 2720/3074/4126/3073/2517 GLB1/HEXB/MANBA/HEXA/FUCA1 5 hsa05215 Prostate cancer 14/494 89/5868 0.0158833046639018 0.164548105057994 1956/3480/7184/3326/2950/64764/6934/10000/80310/595/2263/1387/2064/1499 EGFR/IGF1R/HSP90B1/HSP90AB1/GSTP1/CREB3L2/TCF7L2/AKT3/PDGFD/CCND1/FGFR2/CREBBP/ERBB2/CTNNB1 14 hsa04144 Endocytosis 26/494 201/5868 0.0173337922662957 0.164548105057994 1956/4233/2321/3480/153/2065/8411/1213/2348/7037/7046/11059/5584/84440/1211/9829/4087/857/50807/161/11031/2263/55040/64750/3303/387 EGFR/MET/FLT1/IGF1R/ADRB1/ERBB3/EEA1/CLTC/FOLR1/TFRC/TGFBR1/WWP1/PRKCI/RAB11FIP4/CLTA/DNAJC6/SMAD2/CAV1/ASAP1/AP2A2/RAB31/FGFR2/EPN3/SMURF2/HSPA1A/RHOA 26 hsa05414 Dilated cardiomyopathy 14/494 90/5868 0.0174124978897348 0.164548105057994 3655/1605/3688/3691/3685/3696/153/3693/71/488/113/1756/60/3694 ITGA6/DAG1/ITGB1/ITGB4/ITGAV/ITGB8/ADRB1/ITGB5/ACTG1/ATP2A2/ADCY7/DMD/ACTB/ITGB6 14 hsa04310 Wnt signaling pathway 20/494 150/5868 0.0256763247195531 0.231086922475978 4041/6907/23002/10725/6093/6934/7855/1857/79718/4087/8323/595/4775/1452/5530/6500/7976/1387/1499/387 LRP5/TBL1X/DAAM1/NFAT5/ROCK1/TCF7L2/FZD5/DVL3/TBL1XR1/SMAD2/FZD6/CCND1/NFATC3/CSNK1A1/PPP3CA/SKP1/FZD3/CREBBP/CTNNB1/RHOA 20 hsa04670 Leukocyte transendothelial migration 16/494 116/5868 0.0327811754919346 0.25855301407179 3688/394/71/103910/1500/10627/81/6093/50848/10451/1364/1432/60/100506658/1499/387 ITGB1/ARHGAP5/ACTG1/MYL12B/CTNND1/MYL12A/ACTN4/ROCK1/F11R/VAV3/CLDN4/MAPK14/ACTB/OCLN/CTNNB1/RHOA 16 hsa05210 Colorectal cancer 10/494 62/5868 0.0328028849071211 0.25855301407179 7046/6934/4087/10000/595/26060/54205/1499/332/387 TGFBR1/TCF7L2/SMAD2/AKT3/CCND1/APPL1/CYCS/CTNNB1/BIRC5/RHOA 10 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 5/494 22/5868 0.0328321287710209 0.25855301407179 79586/29940/50515/113189/26229 CHPF/DSE/CHST11/CHST14/B3GAT3 5 hsa03040 Spliceosome 17/494 127/5868 0.0365449197456526 0.276279593277133 3178/58517/6428/10915/57187/23451/55119/6434/3183/6633/3303/6636/6632/8683/6628/27258/220988 HNRNPA1/RBM25/SRSF3/TCERG1/THOC2/SF3B1/PRPF38B/TRA2B/HNRNPC/SNRPD2/HSPA1A/SNRPF/SNRPD1/SRSF9/SNRPB/LSM3/HNRNPA3 17 hsa03060 Protein export 5/494 23/5868 0.0391487823257773 0.282591297275068 7095/11231/29927/60559/3309 SEC62/SEC63/SEC61A1/SPCS3/HSPA5 5 hsa04330 Notch signaling pathway 8/494 47/5868 0.0403701853250097 0.282591297275068 84441/182/4854/1857/23385/3516/6868/1387 MAML2/JAG1/NOTCH3/DVL3/NCSTN/RBPJ/ADAM17/CREBBP 8 hsa05410 Hypertrophic cardiomyopathy (HCM) 12/494 83/5868 0.0438423034114869 0.295429983474528 3655/1605/3688/3691/3685/3696/3693/71/488/1756/60/3694 ITGA6/DAG1/ITGB1/ITGB4/ITGAV/ITGB8/ITGB5/ACTG1/ATP2A2/DMD/ACTB/ITGB6 12 hsa00600 Sphingolipid metabolism 7/494 40/5868 0.0469519083286885 0.295429983474528 427/8613/2720/81537/6609/8560/55304 ASAH1/PLPP3/GLB1/SGPP1/SMPD1/DEGS1/SPTLC3 7 hsa04350 TGF-beta signaling pathway 12/494 84/5868 0.0474250116282103 0.295429983474528 4052/655/6093/7046/659/4087/657/6500/64750/1387/93/387 LTBP1/BMP7/ROCK1/TGFBR1/BMPR2/SMAD2/BMPR1A/SKP1/SMURF2/CREBBP/ACVR2B/RHOA 12 hsa04614 Renin-angiotensin system 4/494 17/5868 0.0489081534610309 0.295429983474528 4311/2028/4012/5476 MME/ENPEP/LNPEP/CTSA 4 hsa04530 Tight junction 17/494 132/5868 0.0500198913819307 0.295429983474528 71/55870/103910/10627/81/6709/5584/50848/4628/1364/10000/5872/60/100506658/1499/387/8531 ACTG1/ASH1L/MYL12B/MYL12A/ACTN4/SPTAN1/PRKCI/F11R/MYH10/CLDN4/AKT3/RAB13/ACTB/OCLN/CTNNB1/RHOA/YBX3 17 hsa00290 Valine, leucine and isoleucine biosynthesis 3/494 11/5868 0.0587644223148887 0.336559873257999 586/55699/587 BCAT1/IARS2/BCAT2 3 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/494 26/5868 0.062264588322526 0.346117858616395 2651/2683/10678/84002/10331 GCNT2/B4GALT1/B3GNT2/B3GNT5/B3GNT3 5 hsa05131 Shigellosis 9/494 61/5868 0.0673898778461796 0.36390534036937 3688/5216/71/6093/8976/10094/1432/60/10163 ITGB1/PFN1/ACTG1/ROCK1/WASL/ARPC3/MAPK14/ACTB/WASF2 9 hsa00270 Cysteine and methionine metabolism 6/494 36/5868 0.0774271198731882 0.406492379334238 3939/1788/6611/10768/4548/3945 LDHA/DNMT3A/SMS/AHCYL1/MTR/LDHB 6 hsa05216 Thyroid cancer 5/494 29/5868 0.0916201059868667 0.468005406257238 999/7175/6934/595/1499 CDH1/TPR/TCF7L2/CCND1/CTNNB1 5 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 9/494 68/5868 0.114937036130959 0.571660521809243 1956/4233/102/525/537/6868/50848/1432/535 EGFR/MET/ADAM10/ATP6V1B1/ATP6AP1/ADAM17/F11R/MAPK14/ATP6V0A1 9 hsa04970 Salivary secretion 11/494 89/5868 0.125875679954373 0.597718385886934 490/153/493/801/2776/3709/6548/3783/6522/113/476 ATP2B1/ADRB1/ATP2B4/CALM1/GNAQ/ITPR2/SLC9A1/KCNN4/SLC4A2/ADCY7/ATP1A1 11 hsa00604 Glycosphingolipid biosynthesis - ganglio series 3/494 15/5868 0.126501245690356 0.597718385886934 2720/3074/3073 GLB1/HEXB/HEXA 3 hsa04977 Vitamin digestion and absorption 4/494 24/5868 0.138044218575009 0.603568541911657 6573/80704/8884/55788 SLC19A1/SLC19A3/SLC5A6/LMBRD1 4 hsa04916 Melanogenesis 12/494 101/5868 0.140145569462992 0.603568541911657 801/2776/64764/6934/7855/113/1857/8323/1910/7976/1387/1499 CALM1/GNAQ/CREB3L2/TCF7L2/FZD5/ADCY7/DVL3/FZD6/EDNRB/FZD3/CREBBP/CTNNB1 12 hsa04974 Protein digestion and absorption 10/494 81/5868 0.140760673830824 0.603568541911657 1284/4311/7373/54407/1282/1803/6510/3783/1290/476 COL4A2/MME/COL14A1/SLC38A2/COL4A1/DPP4/SLC1A5/KCNN4/COL5A2/ATP1A1 10 hsa04145 Phagosome 17/494 153/5868 0.143363291617021 0.603568541911657 3688/3685/81035/821/3693/71/4973/8411/525/29927/537/7037/1778/3920/60/535/22925 ITGB1/ITGAV/COLEC12/CANX/ITGB5/ACTG1/OLR1/EEA1/ATP6V1B1/SEC61A1/ATP6AP1/TFRC/DYNC1H1/LAMP2/ACTB/ATP6V0A1/PLA2R1 17 hsa05213 Endometrial cancer 7/494 52/5868 0.143706795693252 0.603568541911657 1956/999/6934/10000/595/2064/1499 EGFR/CDH1/TCF7L2/AKT3/CCND1/ERBB2/CTNNB1 7 hsa05110 Vibrio cholerae infection 7/494 54/5868 0.165414063491448 0.679636043475734 71/525/29927/537/9601/60/535 ACTG1/ATP6V1B1/SEC61A1/ATP6AP1/PDIA4/ACTB/ATP6V0A1 7 hsa05217 Basal cell carcinoma 7/494 55/5868 0.176784408477198 0.704223569952618 6934/7855/1857/2737/8323/7976/1499 TCF7L2/FZD5/DVL3/GLI3/FZD6/FZD3/CTNNB1 7 hsa05146 Amoebiasis 12/494 106/5868 0.178850430464157 0.704223569952618 3911/1284/3915/3912/1282/2776/81/2335/1290/3315/5272/1992 LAMA5/COL4A2/LAMC1/LAMB1/COL4A1/GNAQ/ACTN4/FN1/COL5A2/HSPB1/SERPINB9/SERPINB1 12 hsa04612 Antigen processing and presentation 9/494 76/5868 0.186786690308149 0.720462948331433 821/5641/972/1508/3326/3309/2923/6892/3303 CANX/LGMN/CD74/CTSB/HSP90AB1/HSPA5/PDIA3/TAPBP/HSPA1A 9 hsa04146 Peroxisome 9/494 79/5868 0.217898034843431 0.817682936907217 5052/11001/54677/5825/2181/51/3417/847/6647 PRDX1/SLC27A2/CROT/ABCD3/ACSL3/ACOX1/IDH1/CAT/SOD1 9 hsa04514 Cell adhesion molecules (CAMs) 14/494 133/5868 0.227309225053535 0.817682936907217 3655/999/3688/5792/3685/2734/3696/4897/9019/5797/50848/1364/100506658/23705 ITGA6/CDH1/ITGB1/PTPRF/ITGAV/GLG1/ITGB8/NRCAM/MPZL1/PTPRM/F11R/CLDN4/OCLN/CADM1 14 hsa00564 Glycerophospholipid metabolism 9/494 80/5868 0.228695457938191 0.817682936907217 8613/1040/23171/10434/23761/10162/10554/137964/55500 PLPP3/CDS1/GPD1L/LYPLA1/PISD/LPCAT3/AGPAT1/GPAT4/ETNK1 9 hsa03320 PPAR signaling pathway 8/494 70/5868 0.233623696259205 0.817682936907217 11001/4973/7316/10580/28965/1376/2181/51 SLC27A2/OLR1/UBC/SORBS1/SLC27A6/CPT2/ACSL3/ACOX1 8 hsa05416 Viral myocarditis 8/494 70/5868 0.233623696259205 0.817682936907217 1605/71/1756/4628/857/595/60/54205 DAG1/ACTG1/DMD/MYH10/CAV1/CCND1/ACTB/CYCS 8 hsa00512 Mucin type O-Glycan biosynthesis 4/494 30/5868 0.242839663236282 0.828682473417824 63917/56913/9334/51301 GALNT11/C1GALT1/B4GALT5/GCNT4 4 hsa05218 Melanoma 8/494 71/5868 0.245535547679355 0.828682473417824 1956/999/4233/1021/3480/10000/80310/595 EGFR/CDH1/MET/CDK6/IGF1R/AKT3/PDGFD/CCND1 8 hsa05219 Bladder cancer 5/494 42/5868 0.276843833137226 0.917955867770802 1956/999/9252/595/2064 EGFR/CDH1/RPS6KA5/CCND1/ERBB2 5 hsa04971 Gastric acid secretion 8/494 74/5868 0.282378100324911 0.920163120024278 801/2776/3709/6548/6522/113/476/60 CALM1/GNAQ/ITPR2/SLC9A1/SLC4A2/ADCY7/ATP1A1/ACTB 8 hsa00010 Glycolysis / Gluconeogenesis 7/494 65/5868 0.305192721167392 0.977651259332833 2597/3939/226/84532/2023/7167/3945 GAPDH/LDHA/ALDOA/ACSS1/ENO1/TPI1/LDHB 7 hsa05010 Alzheimer's disease 16/494 167/5868 0.330675295902467 1 2597/4035/4311/351/801/1337/102/2776/3709/22926/488/23385/6868/5530/54205/7388 GAPDH/LRP1/MME/APP/CALM1/COX6A1/ADAM10/GNAQ/ITPR2/ATF6/ATP2A2/NCSTN/ADAM17/PPP3CA/CYCS/UQCRH 16 hsa00603 Glycosphingolipid biosynthesis - globo series 2/494 14/5868 0.332375685929233 1 3074/3073 HEXB/HEXA 2 hsa05020 Prion diseases 4/494 35/5868 0.33999864766619 1 3915/3309/3303/6647 LAMC1/HSPA5/HSPA1A/SOD1 4 hsa04972 Pancreatic secretion 10/494 101/5868 0.343700748715817 1 490/493/2776/3709/6548/488/6522/113/476/387 ATP2B1/ATP2B4/GNAQ/ITPR2/SLC9A1/ATP2A2/SLC4A2/ADCY7/ATP1A1/RHOA 10 hsa04115 p53 signaling pathway 7/494 68/5868 0.347123436822572 1 1021/4194/50484/595/64393/472/54205 CDK6/MDM4/RRM2B/CCND1/ZMAT3/ATM/CYCS 7 hsa04110 Cell cycle 12/494 124/5868 0.350190011848233 1 1021/5591/7531/7029/6502/4087/595/6500/1387/472/991/1028 CDK6/PRKDC/YWHAE/TFDP2/SKP2/SMAD2/CCND1/SKP1/CREBBP/ATM/CDC20/CDKN1C 12 hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 2/494 15/5868 0.364048676735214 1 2683/10678 B4GALT1/B3GNT2 2 hsa05212 Pancreatic cancer 7/494 70/5868 0.375440769224366 1 1956/1021/7046/4087/10000/595/2064 EGFR/CDK6/TGFBR1/SMAD2/AKT3/CCND1/ERBB2 7 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 3/494 26/5868 0.376470672582175 1 2135/90161/26229 EXTL2/HS6ST2/B3GAT3 3 hsa03018 RNA degradation 7/494 71/5868 0.389649152830851 1 2023/9652/246175/54464/170506/167227/27258 ENO1/TTC37/CNOT6L/XRN1/DHX36/DCP2/LSM3 7 hsa04666 Fc gamma R-mediated phagocytosis 9/494 94/5868 0.394532088376367 1 1072/8613/85477/8976/10451/10094/10000/50807/10163 CFL1/PLPP3/SCIN/WASL/VAV3/ARPC3/AKT3/ASAP1/WASF2 9 hsa00770 Pantothenate and CoA biosynthesis 2/494 16/5868 0.395131437171412 1 586/587 BCAT1/BCAT2 2 hsa00052 Galactose metabolism 3/494 27/5868 0.400021873865696 1 2548/2720/2683 GAA/GLB1/B4GALT1 3 hsa00480 Glutathione metabolism 5/494 50/5868 0.413791389764067 1 6611/2878/2950/50484/3417 SMS/GPX3/GSTP1/RRM2B/IDH1 5 hsa04020 Calcium signaling pathway 16/494 177/5868 0.420919054929214 1 1956/490/153/493/801/2065/5025/5257/2776/3709/488/7416/113/1910/5530/2064 EGFR/ATP2B1/ADRB1/ATP2B4/CALM1/ERBB3/P2RX4/PHKB/GNAQ/ITPR2/ATP2A2/VDAC1/ADCY7/EDNRB/PPP3CA/ERBB2 16 hsa05145 Toxoplasmosis 12/494 132/5868 0.434720661662641 1 3655/3911/3915/3912/3688/3588/10000/1432/331/23118/54205/3303 ITGA6/LAMA5/LAMC1/LAMB1/ITGB1/IL10RB/AKT3/MAPK14/XIAP/TAB2/CYCS/HSPA1A 12 hsa05014 Amyotrophic lateral sclerosis (ALS) 5/494 53/5868 0.464817233673765 1 1432/5530/847/54205/6647 MAPK14/PPP3CA/CAT/CYCS/SOD1 5 hsa05214 Glioma 6/494 65/5868 0.470212818816866 1 1956/1021/3480/801/10000/595 EGFR/CDK6/IGF1R/CALM1/AKT3/CCND1 6 hsa00330 Arginine and proline metabolism 5/494 54/5868 0.481545562818509 1 6611/26/6303/5832/8659 SMS/AOC1/SAT1/ALDH18A1/ALDH4A1 5 hsa05223 Non-small cell lung cancer 5/494 54/5868 0.481545562818509 1 1956/1021/10000/595/2064 EGFR/CDK6/AKT3/CCND1/ERBB2 5 hsa00100 Steroid biosynthesis 2/494 19/5868 0.483710275506451 1 3988/1718 LIPA/DHCR24 2 hsa04540 Gap junction 8/494 90/5868 0.490829127916916 1 1956/153/2697/2776/3709/10746/113/80310 EGFR/ADRB1/GJA1/GNAQ/ITPR2/MAP3K2/ADCY7/PDGFD 8 hsa00640 Propanoate metabolism 3/494 32/5868 0.512809125191991 1 3939/84532/3945 LDHA/ACSS1/LDHB 3 hsa00310 Lysine degradation 4/494 44/5868 0.513688474866695 1 55870/64324/29072/5351 ASH1L/NSD1/SETD2/PLOD1 4 hsa04270 Vascular smooth muscle contraction 10/494 116/5868 0.517632806028886 1 801/2776/3709/2768/6093/113/4659/4637/4660/387 CALM1/GNAQ/ITPR2/GNA12/ROCK1/ADCY7/PPP1R12A/MYL6/PPP1R12B/RHOA 10 hsa01040 Biosynthesis of unsaturated fatty acids 2/494 21/5868 0.538128001604131 1 9524/51 TECR/ACOX1 2 hsa04720 Long-term potentiation 6/494 70/5868 0.544252671171914 1 801/2776/3709/4659/5530/1387 CALM1/GNAQ/ITPR2/PPP1R12A/PPP3CA/CREBBP 6 hsa04621 NOD-like receptor signaling pathway 5/494 58/5868 0.546434190932496 1 7184/3326/1432/331/23118 HSP90B1/HSP90AB1/MAPK14/XIAP/TAB2 5 hsa04976 Bile secretion 6/494 71/5868 0.558523765172627 1 6513/6548/6522/113/57552/476 SLC2A1/SLC9A1/SLC4A2/ADCY7/NCEH1/ATP1A1 6 hsa00520 Amino sugar and nucleotide sugar metabolism 4/494 48/5868 0.584156691480652 1 3074/3073/10020/80146 HEXB/HEXA/GNE/UXS1 4 hsa04320 Dorso-ventral axis formation 2/494 24/5868 0.612056404807904 1 1956/4854 EGFR/NOTCH3 2 hsa00790 Folate biosynthesis 1/494 11/5868 0.62024065136285 1 8836 GGH 1 hsa04370 VEGF signaling pathway 6/494 76/5868 0.626493540287093 1 10725/3315/10000/1432/4775/5530 NFAT5/HSPB1/AKT3/MAPK14/NFATC3/PPP3CA 6 hsa03013 RNA transport 12/494 151/5868 0.627351996704307 1 1915/10209/7175/5903/5411/57187/8661/3837/5901/8894/8667/10284 EEF1A1/EIF1/TPR/RANBP2/PNN/THOC2/EIF3A/KPNB1/RAN/EIF2S2/EIF3H/SAP18 12 hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 2/494 25/5868 0.634605978207554 1 80055/8733 PGAP1/GPAA1 2 hsa00620 Pyruvate metabolism 3/494 40/5868 0.666580756127854 1 3939/84532/3945 LDHA/ACSS1/LDHB 3 hsa00030 Pentose phosphate pathway 2/494 27/5868 0.676604884061187 1 226/7086 ALDOA/TKT 2 hsa04966 Collecting duct acid secretion 2/494 27/5868 0.676604884061187 1 525/535 ATP6V1B1/ATP6V0A1 2 hsa00500 Starch and sucrose metabolism 4/494 54/5868 0.677881523862223 1 178/2548/2990/80146 AGL/GAA/GUSB/UXS1 4 hsa00920 Sulfur metabolism 1/494 13/5868 0.681604597305177 1 50515 CHST11 1 hsa03450 Non-homologous end-joining 1/494 13/5868 0.681604597305177 1 5591 PRKDC 1 hsa04660 T cell receptor signaling pathway 8/494 108/5868 0.69957736095912 1 10725/1739/10451/10000/1432/4775/5530/387 NFAT5/DLG1/VAV3/AKT3/MAPK14/NFATC3/PPP3CA/RHOA 8 hsa04340 Hedgehog signaling pathway 4/494 56/5868 0.705640018572756 1 4036/655/2737/1452 LRP2/BMP7/GLI3/CSNK1A1 4 hsa05211 Renal cell carcinoma 5/494 70/5868 0.713462902288756 1 4233/6513/2549/10000/1387 MET/SLC2A1/GAB1/AKT3/CREBBP 5 hsa00071 Fatty acid degradation 3/494 43/5868 0.714265865995747 1 1376/2181/51 CPT2/ACSL3/ACOX1 3 hsa00860 Porphyrin and chlorophyll metabolism 3/494 43/5868 0.714265865995747 1 2495/2990/2512 FTH1/GUSB/FTL 3 hsa04962 Vasopressin-regulated water reabsorption 3/494 44/5868 0.728942260468605 1 8655/64764/1778 DYNLL1/CREB3L2/DYNC1H1 3 hsa04114 Oocyte meiosis 8/494 112/5868 0.737635083120195 1 3480/801/3709/7531/113/5530/6500/991 IGF1R/CALM1/ITPR2/YWHAE/ADCY7/PPP3CA/SKP1/CDC20 8 hsa04210 Apoptosis 6/494 87/5868 0.752570187641974 1 10000/8837/331/5530/472/54205 AKT3/CFLAR/XIAP/PPP3CA/ATM/CYCS 6 hsa04722 Neurotrophin signaling pathway 9/494 127/5868 0.753691932715314 1 801/9500/9252/7531/57498/2549/10000/1432/387 CALM1/MAGED1/RPS6KA5/YWHAE/KIDINS220/GAB1/AKT3/MAPK14/RHOA 9 hsa04975 Fat digestion and absorption 3/494 46/5868 0.756512803107988 1 19/8613/10554 ABCA1/PLPP3/AGPAT1 3 hsa04912 GnRH signaling pathway 7/494 101/5868 0.758112080766567 1 1956/801/2776/3709/10746/113/1432 EGFR/CALM1/GNAQ/ITPR2/MAP3K2/ADCY7/MAPK14 7 hsa04662 B cell receptor signaling pathway 5/494 75/5868 0.768681248380354 1 10725/10451/10000/4775/5530 NFAT5/VAV3/AKT3/NFATC3/PPP3CA 5 hsa00360 Phenylalanine metabolism 1/494 17/5868 0.776230241842615 1 4282 MIF 1 hsa00450 Selenocompound metabolism 1/494 17/5868 0.776230241842615 1 4548 MTR 1 hsa03410 Base excision repair 2/494 33/5868 0.779363727403338 1 3146/6996 HMGB1/TDG 2 hsa05016 Huntington's disease 13/494 183/5868 0.780125021852203 1 1337/1213/2776/64764/7416/548644/1211/161/5978/1387/54205/7388/6647 COX6A1/CLTC/GNAQ/CREB3L2/VDAC1/POLR2J3/CLTA/AP2A2/REST/CREBBP/CYCS/UQCRH/SOD1 13 hsa04260 Cardiac muscle contraction 5/494 77/5868 0.788371626317412 1 1337/6548/488/476/7388 COX6A1/SLC9A1/ATP2A2/ATP1A1/UQCRH 5 hsa00670 One carbon pool by folate 1/494 18/5868 0.795123125200973 1 4548 MTR 1 hsa00561 Glycerolipid metabolism 3/494 50/5868 0.804845724976787 1 8613/10554/137964 PLPP3/AGPAT1/GPAT4 3 hsa00051 Fructose and mannose metabolism 2/494 36/5868 0.81913604519137 1 226/7167 ALDOA/TPI1 2 hsa03022 Basal transcription factors 2/494 36/5868 0.81913604519137 1 11037/2969 STON1/GTF2I 2 hsa04150 mTOR signaling pathway 3/494 52/5868 0.825828795461618 1 6194/253260/10000 RPS6/RICTOR/AKT3 3 hsa00592 alpha-Linolenic acid metabolism 1/494 20/5868 0.828266311888413 1 51 ACOX1 1 hsa04910 Insulin signaling pathway 9/494 138/5868 0.833108546106723 1 5792/6194/801/5257/5584/10580/10000/3643/2194 PTPRF/RPS6/CALM1/PHKB/PRKCI/SORBS1/AKT3/INSR/FASN 9 hsa03015 mRNA surveillance pathway 5/494 83/5868 0.839655214570213 1 124540/23049/5411/8731/10284 MSI2/SMG1/PNN/RNMT/SAP18 5 hsa04630 Jak-STAT signaling pathway 10/494 155/5868 0.852283696596134 1 1441/3572/1442/5618/3977/3588/8554/10000/595/1387 CSF3R/IL6ST/CSH1/PRLR/LIFR/IL10RB/PIAS1/AKT3/CCND1/CREBBP 10 hsa04730 Long-term depression 4/494 70/5868 0.852352376160018 1 3480/2776/3709/2768 IGF1R/GNAQ/ITPR2/GNA12 4 hsa00410 beta-Alanine metabolism 1/494 22/5868 0.856056967040579 1 6611 SMS 1 hsa04710 Circadian rhythm 1/494 22/5868 0.856056967040579 1 6500 SKP1 1 hsa04914 Progesterone-mediated oocyte maturation 5/494 86/5868 0.861209503780297 1 3480/3326/113/10000/1432 IGF1R/HSP90AB1/ADCY7/AKT3/MAPK14 5 hsa04012 ErbB signaling pathway 5/494 87/5868 0.867833852325317 1 1956/2065/2549/10000/2064 EGFR/ERBB3/GAB1/AKT3/ERBB2 5 hsa03430 Mismatch repair 1/494 23/5868 0.868220473417923 1 27030 MLH3 1 hsa04964 Proximal tubule bicarbonate reclamation 1/494 23/5868 0.868220473417923 1 476 ATP1A1 1 hsa05221 Acute myeloid leukemia 3/494 57/5868 0.870008855705839 1 6934/10000/595 TCF7L2/AKT3/CCND1 3 hsa05220 Chronic myeloid leukemia 4/494 73/5868 0.874131066525543 1 1021/7046/10000/595 CDK6/TGFBR1/AKT3/CCND1 4 hsa04010 MAPK signaling pathway 18/494 268/5868 0.875073733528355 1 1956/4763/9252/5921/2768/57551/10746/7046/3315/51347/10000/1432/23118/5530/2263/9693/3303/2005 EGFR/NF1/RPS6KA5/RASA1/GNA12/TAOK1/MAP3K2/TGFBR1/HSPB1/TAOK3/AKT3/MAPK14/TAB2/PPP3CA/FGFR2/RAPGEF2/HSPA1A/ELK4 18 hsa00380 Tryptophan metabolism 2/494 42/5868 0.879944156314342 1 26/847 AOC1/CAT 2 hsa04960 Aldosterone-regulated sodium reabsorption 2/494 42/5868 0.879944156314342 1 476/3643 ATP1A1/INSR 2 hsa05142 Chagas disease (American trypanosomiasis) 6/494 104/5868 0.881751181380375 1 2776/7046/4087/10000/1432/8837 GNAQ/TGFBR1/SMAD2/AKT3/MAPK14/CFLAR 6 hsa05160 Hepatitis C 8/494 134/5868 0.887547187156515 1 1956/8554/1364/10000/1432/7098/100506658/57506 EGFR/PIAS1/CLDN4/AKT3/MAPK14/TLR3/OCLN/MAVS 8 hsa00280 Valine, leucine and isoleucine degradation 2/494 44/5868 0.895601441452197 1 586/587 BCAT1/BCAT2 2 hsa02010 ABC transporters 2/494 44/5868 0.895601441452197 1 19/5825 ABCA1/ABCD3 2 hsa03050 Proteasome 2/494 44/5868 0.895601441452197 1 51371/5693 POMP/PSMB5 2 hsa04973 Carbohydrate digestion and absorption 2/494 44/5868 0.895601441452197 1 476/10000 ATP1A1/AKT3 2 hsa00514 Other types of O-glycan biosynthesis 2/494 46/5868 0.909342982708184 1 283464/2683 GXYLT1/B4GALT1 2 hsa00340 Histidine metabolism 1/494 29/5868 0.922438250608387 1 26 AOC1 1 hsa03020 RNA polymerase 1/494 29/5868 0.922438250608387 1 548644 POLR2J3 1 hsa04744 Phototransduction 1/494 29/5868 0.922438250608387 1 801 CALM1 1 hsa00020 Citrate cycle (TCA cycle) 1/494 30/5868 0.929000248244875 1 3417 IDH1 1 hsa04920 Adipocytokine signaling pathway 3/494 68/5868 0.934075630611548 1 6513/10000/2181 SLC2A1/AKT3/ACSL3 3 hsa05144 Malaria 2/494 51/5868 0.93664560741291 1 4035/4233 LRP1/MET 2 hsa04610 Complement and coagulation cascades 3/494 69/5868 0.938151075875893 1 2153/4179/7035 F5/CD46/TFPI 3 hsa00040 Pentose and glucuronate interconversions 1/494 32/5868 0.940508534149227 1 2990 GUSB 1 hsa00250 Alanine, aspartate and glutamate metabolism 1/494 32/5868 0.940508534149227 1 8659 ALDH4A1 1 hsa00260 Glycine, serine and threonine metabolism 1/494 32/5868 0.940508534149227 1 2731 GLDC 1 hsa04640 Hematopoietic cell lineage 4/494 88/5868 0.946092982912196 1 1441/3655/4311/7037 CSF3R/ITGA6/MME/TFRC 4 hsa05140 Leishmaniasis 3/494 72/5868 0.949021892158293 1 3688/1432/23118 ITGB1/MAPK14/TAB2 3 hsa05143 African trypanosomiasis 1/494 35/5868 0.954375321178102 1 2776 GNAQ 1 hsa05323 Rheumatoid arthritis 4/494 91/5868 0.954899831061664 1 2321/525/537/535 FLT1/ATP6V1B1/ATP6AP1/ATP6V0A1 4 hsa00565 Ether lipid metabolism 1/494 36/5868 0.958239300492009 1 8613 PLPP3 1 hsa00562 Inositol phosphate metabolism 2/494 57/5868 0.959160130096763 1 7167/51477 TPI1/ISYNA1 2 hsa04070 Phosphatidylinositol signaling system 3/494 78/5868 0.965635750806885 1 801/1040/3709 CALM1/CDS1/ITPR2 3 hsa04664 Fc epsilon RI signaling pathway 3/494 79/5868 0.967852122698046 1 10451/10000/1432 VAV3/AKT3/MAPK14 3 hsa05012 Parkinson's disease 6/494 130/5868 0.968307328718362 1 1337/7416/7332/7317/54205/7388 COX6A1/VDAC1/UBE2L3/UBA1/CYCS/UQCRH 6 hsa00240 Pyrimidine metabolism 4/494 99/5868 0.97231326345877 1 548644/50808/124583/50484 POLR2J3/AK3/CANT1/RRM2B 4 hsa00350 Tyrosine metabolism 1/494 41/5868 0.973177201750074 1 4282 MIF 1 hsa04620 Toll-like receptor signaling pathway 4/494 102/5868 0.977040810954158 1 10000/1432/23118/7098 AKT3/MAPK14/TAB2/TLR3 4 hsa03420 Nucleotide excision repair 1/494 44/5868 0.979438108559562 1 1642 DDB1 1 hsa04060 Cytokine-cytokine receptor interaction 14/494 265/5868 0.98219522188648 1 1956/1441/3572/4233/2321/5618/655/3977/3588/7046/659/657/93/4055 EGFR/CSF3R/IL6ST/MET/FLT1/PRLR/BMP7/LIFR/IL10RB/TGFBR1/BMPR2/BMPR1A/ACVR2B/LTBR 14 hsa04672 Intestinal immune network for IgA production 1/494 48/5868 0.985577353890106 1 4055 LTBR 1 hsa04930 Type II diabetes mellitus 1/494 48/5868 0.985577353890106 1 3643 INSR 1 hsa04622 RIG-I-like receptor signaling pathway 2/494 71/5868 0.985782327910955 1 1432/57506 MAPK14/MAVS 2 hsa04380 Osteoclast differentiation 5/494 128/5868 0.986429267871259 1 7046/10000/1432/23118/5530 TGFBR1/AKT3/MAPK14/TAB2/PPP3CA 5 hsa00190 Oxidative phosphorylation 5/494 132/5868 0.989376549399206 1 1337/525/537/535/7388 COX6A1/ATP6V1B1/ATP6AP1/ATP6V0A1/UQCRH 5 hsa00983 Drug metabolism - other enzymes 1/494 52/5868 0.989886159229292 1 2990 GUSB 1 hsa03008 Ribosome biogenesis in eukaryotes 2/494 79/5868 0.992338574077791 1 54464/5901 XRN1/RAN 2 hsa00140 Steroid hormone biosynthesis 1/494 56/5868 0.992909507591181 1 412 STS 1 hsa04623 Cytosolic DNA-sensing pathway 1/494 56/5868 0.992909507591181 1 57506 MAVS 1 hsa00590 Arachidonic acid metabolism 1/494 59/5868 0.994568450415918 1 2878 GPX3 1 hsa00230 Purine metabolism 6/494 162/5868 0.995013216505422 1 548644/113/124583/50484/10846/5150 POLR2J3/ADCY7/CANT1/RRM2B/PDE10A/PDE7A 6 hsa00970 Aminoacyl-tRNA biosynthesis 1/494 63/5868 0.996193817500931 1 55699 IARS2 1 hsa00830 Retinol metabolism 1/494 64/5868 0.996517720025399 1 9249 DHRS3 1 hsa04062 Chemokine signaling pathway 7/494 189/5868 0.997172479197268 1 6093/113/8976/10451/10000/59345/387 ROCK1/ADCY7/WASL/VAV3/AKT3/GNB4/RHOA 7 hsa04650 Natural killer cell mediated cytotoxicity 4/494 136/5868 0.997586873866231 1 10725/10451/4775/5530 NFAT5/VAV3/NFATC3/PPP3CA 4 hsa00980 Metabolism of xenobiotics by cytochrome P450 1/494 71/5868 0.998132385636725 1 2950 GSTP1 1 hsa00982 Drug metabolism - cytochrome P450 1/494 73/5868 0.998437151505785 1 2950 GSTP1 1 hsa05322 Systemic lupus erythematosus 3/494 136/5868 0.999473648460715 1 81/6632/6628 ACTN4/SNRPD1/SNRPB 3 hsa04080 Neuroactive ligand-receptor interaction 9/494 272/5868 0.999843828249871 1 1442/5618/153/2564/2908/5025/9294/1903/1910 CSH1/PRLR/ADRB1/GABRE/NR3C1/P2RX4/S1PR2/S1PR3/EDNRB 9 hsa04740 Olfactory transduction 1/494 388/5868 1 1 801 CALM1 1