ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	66/1123	332/18367	8.89878834632801e-18	8.56063438916754e-15	EGFR/AHNAK/ITGA6/RPL23A/CD46/CDH1/ITGB1/RPL15/ANXA1/RPL6/PFN1/IQGAP1/LDHA/PRDX1/KTN1/RPS2/S100P/MACF1/RTN4/RPL7A/ALDOA/RPL14/ANK3/PLEC/CTNND1/SPTBN1/P2RX4/HSP90AB1/S100A11/USO1/KRT18/PKN2/YWHAE/ENO1/RPL24/DLG1/LRRFIP1/ARHGAP18/MPP7/SPTAN1/COBLL1/NOTCH3/FMNL2/DOCK9/HSPA5/KIF5B/GAPVD1/EFHD2/PTPRM/F11R/BMPR2/ARGLU1/RANBP1/PKP2/ASAP1/RAN/CAST/IDH1/ANXA2/ESYT2/EEF1D/CTNNB1/FASN/HSPA1A/SND1/WASF2	66
GO:0003735	structural constituent of ribosome	40/1123	182/18367	9.55978147737379e-13	4.59825489061679e-10	RPL23A/RPL3/RPL27A/RPL13A/RPL15/RPS3A/RPS10/RPL9/RPL6/RPLP0/RPL31/RPS20/RPS11/RPL7/RPL23/RPL36A/RPS6/RPL5/RPS2/RPS8/RPS16/RPL7A/RPL14/RPL39/RPS3/RPS17/RPL17/RPS4X/RPL26/RPL24/RPS21/RPS25/RPS13/RPSA/RPL10A/RPL38/RPS9/RPL35/RPL27/RPL4	40
GO:0051020	GTPase binding	51/1123	291/18367	7.87096633680732e-12	2.52395653866955e-09	PFN1/IQGAP2/GOLGA4/IQGAP1/ABCA1/MYCBP2/DIAPH2/EXPH5/YBX1/DAAM1/SPTBN1/CDKL5/MYO1C/CHML/RASA1/PKN2/RANBP2/TRIP11/TNPO1/ENO1/AKAP13/GCC2/ATP6AP1/ROCK1/CCDC186/FMNL2/NCKAP1/PPP1R9A/DVL3/EVI5/RAB11FIP4/C9orf72/RHOBTB3/KPNB1/RAB3GAP1/CLTA/IPO7/INF2/RAB3GAP2/RANBP1/CAV1/TMEM127/RANBP17/ABI2/ANXA2/CYFIP2/IPO9/BIRC5/SOD1/CDC42SE1/YBX3	51
GO:0031267	small GTPase binding	45/1123	259/18367	1.80742944335594e-10	4.34686781127104e-08	PFN1/IQGAP2/GOLGA4/IQGAP1/ABCA1/MYCBP2/DIAPH2/EXPH5/DAAM1/CDKL5/MYO1C/CHML/PKN2/RANBP2/TRIP11/TNPO1/AKAP13/GCC2/ATP6AP1/ROCK1/CCDC186/FMNL2/NCKAP1/DVL3/EVI5/RAB11FIP4/C9orf72/RHOBTB3/KPNB1/RAB3GAP1/IPO7/INF2/RAB3GAP2/RANBP1/CAV1/TMEM127/RANBP17/ABI2/ANXA2/CYFIP2/IPO9/BIRC5/SOD1/CDC42SE1/YBX3	45
GO:0019838	growth factor binding	29/1123	141/18367	6.40793124077831e-09	1.23288597072575e-06	EGFR/LRP2/ITGA6/CRIM1/IL6ST/NRP2/ITGB4/ITGAV/FLT1/NRP1/GLG1/IGF1R/RPS2/COL4A1/TGFBR3/ERBB3/LTBP1/FURIN/LIFR/GPC1/LTBP3/TGFBR1/BMPR2/TSKU/INSR/FGFR2/ERBB2/ACVR2B/RHBDF1	29
GO:0005178	integrin binding	27/1123	144/18367	1.59468139803697e-07	2.55680584151927e-05	FBN1/EGFR/LAMA5/LAMB1/ITGB1/ITGB4/UTRN/ITGAV/ITGB8/FBLN1/ITGB5/DST/PLPP3/PPIA/ADAM10/ACTN4/FN1/P4HB/FERMT1/ADAM17/F11R/NISCH/HMGB1/SEMA7A/S1PR2/S1PR3/ITGB6	27
GO:0097718	disordered domain specific binding	12/1123	36/18367	8.17638901237407e-07	0.000112366946141484	GAPDH/GJA1/CALM1/NCOA3/HSP90AB1/CLTC/FN1/GJA5/SMAD2/AP2A2/CTNNB1/HSPA1A	12
GO:0001618	virus receptor activity	17/1123	76/18367	2.54616610930922e-06	0.000306176474644433	EGFR/DAG1/CD46/ITGB1/ITGAV/SLC52A1/ITGB5/DPP4/SLC1A5/SCARB2/TFRC/RPSA/NPC1/F11R/SLC52A2/ITGB6/HSPA1A	17
GO:0140272	exogenous protein binding	17/1123	77/18367	3.0834739176683e-06	0.000329589100977434	EGFR/DAG1/CD46/ITGB1/ITGAV/SLC52A1/ITGB5/DPP4/SLC1A5/SCARB2/TFRC/RPSA/NPC1/F11R/SLC52A2/ITGB6/HSPA1A	17
GO:0003712	transcription coregulator activity	55/1123	489/18367	9.07208324234745e-06	0.000872734407913825	N4BP2L2/NPM1/BRD4/NCOA3/TBL1X/SMARCA2/MAGED1/DDX17/SF1/KMT2C/MAML2/DNMT3A/TRIP11/NCOR1/CCAR1/PTPN14/ACTN4/ZNF451/TCERG1/NSD1/JMJD1C/ARID1A/RSF1/KDM5A/DCAF6/MED13/UBE2L3/MIER1/SMARCC1/SERTAD2/PARP14/SIAH2/TBL1XR1/PIAS1/TLE4/SPEN/JADE1/HMGB1/IRF2BP2/NCOA2/CCND1/ARID5B/ATF7IP/TRIM38/VGLL1/RERE/CREBBP/SUB1/TRIM13/CTNNB1/HSPA1A/SND1/SAP18/RCOR3/FUS	55
GO:0050998	nitric-oxide synthase binding	7/1123	15/18367	1.3061815129242e-05	0.00106839055497851	SLC6A4/ATP2B4/CD74/CALM1/DMD/CAV1/ACTB	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	18/1123	94/18367	1.33271171099191e-05	0.00106839055497851	AGL/GANAB/GAA/EDEM3/GLB1/HEXB/MANBA/HEXA/MOGS/MAN2A1/GM2A/MAN1A2/GUSB/FUCA1/NAGLU/MAN1C1/GNE/MAN1B1	18
GO:0017154	semaphorin receptor activity	6/1123	12/18367	3.46032774002505e-05	0.00256064252761853	MET/NRP2/NRP1/PLXNB1/PLXNB2/PLXNA1	6
GO:0030165	PDZ domain binding	16/1123	84/18367	4.24768971626392e-05	0.00289325357691864	CRIM1/ATP2B1/ADRB1/ATP2B4/GJA1/TGFBR3/KIDINS220/SLC22A5/ARHGAP29/CLCN3/ADAM17/F11R/ACOX1/FZD3/RAPGEF2/CADM1	16
GO:0098631	cell adhesion mediator activity	13/1123	59/18367	4.51131015112055e-05	0.00289325357691864	ITGB1/ANXA1/BCAM/DSC2/DSG2/S100A11/KRT18/CD47/PALLD/RPSA/DSP/PKP2/ANXA2	13
GO:0038024	cargo receptor activity	15/1123	77/18367	5.57473383770783e-05	0.00318049763389701	LRP2/LRP1/COLEC12/LGALS3BP/ABCA1/OLR1/LRP10/VLDLR/SCARB2/FOLR1/TFRC/MIA3/SCARA3/PRSS12/INSR	15
GO:0044325	transmembrane transporter binding	21/1123	133/18367	5.62042201416312e-05	0.00318049763389701	AKAP9/TCAF1/SLC5A3/CALM1/ANK3/HSP90AB1/ITPR2/YWHAE/DLG1/ATP2A2/ACTN4/GRINA/VDAC1/PPP1R9A/GPD1L/S100A10/PKP2/CAV1/PKD2/USP10/CTNNB1	21
GO:0031994	insulin-like growth factor I binding	6/1123	13/18367	6.09349400224867e-05	0.00319055459958068	LRP2/ITGA6/ITGB4/ITGAV/IGF1R/INSR	6
GO:0016798	hydrolase activity, acting on glycosyl bonds	22/1123	144/18367	6.30151116341299e-05	0.00319055459958068	AGL/GANAB/GAA/EDEM3/GLB1/HEXB/MANBA/HEXA/MOGS/MAN2A1/GM2A/MAN1A2/CLN5/GUSB/SMPD1/FUCA1/NAGLU/MAN1C1/GNE/TLR3/TDG/MAN1B1	22
GO:0035198	miRNA binding	9/1123	34/18367	0.00015076046701025	0.00725157846319304	NEAT1/HNRNPA1/KCNQ1OT1/YBX1/PUM2/PUM1/AGO2/HNRNPA2B1/RC3H1	9
GO:0015924	mannosyl-oligosaccharide mannosidase activity	5/1123	10/18367	0.000164720764097944	0.00754577976486774	EDEM3/MAN2A1/MAN1A2/MAN1C1/MAN1B1	5
GO:0019787	ubiquitin-like protein transferase activity	48/1123	458/18367	0.000187898622046893	0.00821629429132321	RNF43/MYCBP2/ZNRF3/RNF128/HECTD1/KLHL42/LMO7/SEL1L/UBR5/BIRC6/RANBP2/NHLRC3/RNF13/ZNF451/RNF217/TRIM56/UFL1/WWP1/TTC3/UBR4/HERC4/UBE2L3/TRIM44/AMFR/TRIM33/TRIP12/LTN1/SIAH2/PIAS1/MIB1/UBE4A/RBBP6/RNF19A/FBXL5/XIAP/RNF170/UBE2H/RNF167/UBE4B/RNF213/TRIM38/SHPRH/UBR3/HERC2/SMURF2/RC3H1/TRIM13/UBE2C	48
GO:0061659	ubiquitin-like protein ligase activity	36/1123	316/18367	0.000240077659209517	0.00972114895553748	RNF43/MYCBP2/ZNRF3/RNF128/HECTD1/UBR5/RANBP2/NHLRC3/RNF13/ZNF451/RNF217/TRIM56/UFL1/WWP1/UBR4/TRIM44/AMFR/TRIP12/LTN1/SIAH2/PIAS1/UBE4A/RBBP6/RNF19A/XIAP/RNF170/RNF167/UBE4B/TRIM38/SHPRH/UBR3/HERC2/SMURF2/RC3H1/TRIM13/UBE2C	36
GO:0015923	mannosidase activity	6/1123	16/18367	0.000242523466666216	0.00972114895553748	EDEM3/MANBA/MAN2A1/MAN1A2/MAN1C1/MAN1B1	6
GO:0003779	actin binding	46/1123	440/18367	0.000268041123079009	0.0103142224160803	EGFR/SYNE2/DAG1/ITGB1/UTRN/PFN1/IQGAP2/IQGAP1/MACF1/SLC6A4/DIAPH2/PHACTR2/CFL1/DST/SCIN/ALDOA/DAAM1/PLEC/SPTBN1/MYO1C/ADD3/ACTN4/SPTAN1/PALLD/RAI14/COBLL1/TRPM7/FMNL2/P4HB/FERMT1/PPP1R9A/MTSS1/DMD/SORBS1/TRPV4/MYH10/TMSB4X/WASL/MYO7A/ARPC3/INF2/COBL/MYO6/PHACTR4/WASF2/DSTN	46
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	5/1123	11/18367	0.00028678154752682	0.0106109172584923	DSC2/DSG2/CD47/DSP/PKP2	5
GO:0003713	transcription coactivator activity	31/1123	262/18367	0.000328138617303793	0.0116914574017129	NPM1/BRD4/NCOA3/SMARCA2/MAGED1/DDX17/KMT2C/MAML2/TRIP11/CCAR1/ACTN4/TCERG1/ARID1A/KDM5A/DCAF6/MED13/UBE2L3/SMARCC1/SERTAD2/JADE1/HMGB1/NCOA2/ARID5B/TRIM38/VGLL1/RERE/CREBBP/SUB1/TRIM13/CTNNB1/FUS	31
GO:0061980	regulatory RNA binding	10/1123	46/18367	0.000378993522028585	0.0130211345782678	NEAT1/HNRNPA1/DICER1/KCNQ1OT1/YBX1/PUM2/PUM1/AGO2/HNRNPA2B1/RC3H1	10
GO:0090482	vitamin transmembrane transporter activity	8/1123	31/18367	0.00042430120007863	0.0140364483051536	SLC2A1/SLC52A1/SLC19A1/SLC19A3/SLC5A6/LMBRD1/SLC52A2/SLC2A8	8
GO:0019199	transmembrane receptor protein kinase activity	20/1123	143/18367	0.000444205699764345	0.0140364483051536	EGFR/CRIM1/MET/NRP2/EFEMP1/FLT1/NRP1/IGF1R/TGFBR3/ERBB3/LTBP1/TGFBR1/EPHB4/BMPR2/DDR1/BMPR1A/INSR/FGFR2/ERBB2/ACVR2B	20
GO:0003714	transcription corepressor activity	24/1123	187/18367	0.000464144521410016	0.0140364483051536	N4BP2L2/TBL1X/SF1/DNMT3A/NCOR1/CCAR1/ZNF451/TCERG1/NSD1/MIER1/PARP14/SIAH2/TBL1XR1/PIAS1/TLE4/SPEN/IRF2BP2/CCND1/ATF7IP/RERE/CREBBP/HSPA1A/SAP18/RCOR3	24
GO:0005024	transforming growth factor beta-activated receptor activity	5/1123	12/18367	0.000466908883331513	0.0140364483051536	TGFBR3/LTBP1/TGFBR1/BMPR2/BMPR1A	5
GO:0008238	exopeptidase activity	16/1123	103/18367	0.000501452104715418	0.0146180886283707	MME/CPD/CTSC/DPP4/ENPEP/LNPEP/CPM/TFRC/TPP1/NPEPPS/MMP15/CTSA/NAALADL2/DPP7/ERAP1/GGH	16
GO:0098632	cell-cell adhesion mediator activity	10/1123	49/18367	0.000646702326548354	0.0180808562385469	ANXA1/DSC2/DSG2/S100A11/KRT18/CD47/PALLD/DSP/PKP2/ANXA2	10
GO:0004842	ubiquitin-protein transferase activity	44/1123	433/18367	0.000657827409926343	0.0180808562385469	RNF43/MYCBP2/ZNRF3/RNF128/HECTD1/KLHL42/LMO7/SEL1L/UBR5/BIRC6/NHLRC3/RNF13/RNF217/TRIM56/WWP1/TTC3/UBR4/HERC4/UBE2L3/TRIM44/AMFR/TRIM33/TRIP12/LTN1/SIAH2/MIB1/UBE4A/RBBP6/RNF19A/FBXL5/XIAP/RNF170/UBE2H/RNF167/UBE4B/RNF213/TRIM38/SHPRH/UBR3/HERC2/SMURF2/RC3H1/TRIM13/UBE2C	44
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	6/1123	19/18367	0.000701216376872946	0.0187380598486604	TGFBR3/LTBP1/TGFBR1/BMPR2/BMPR1A/ACVR2B	6
GO:0015291	secondary active transmembrane transporter activity	28/1123	240/18367	0.000778558152494646	0.0202425119648608	SLC26A2/SLC13A4/SLC6A4/SLC19A1/SLC38A2/SLC5A3/SLC22A11/SLC16A12/SLC1A5/SLC17A5/SLC11A2/SLC5A6/SLC16A4/SLC9A1/SLC7A6/ANKH/SLC28A2/SLC22A5/SLC35D1/SLC16A1/SLC4A2/SLC38A1/SLC1A3/CLCN3/SLC13A3/SLC22A18/SLC16A2/SLC35E1	28
GO:0008509	anion transmembrane transporter activity	34/1123	314/18367	0.000879253758946259	0.0221321002577362	SLC26A2/SLC2A1/SLC13A4/SLC6A4/SLC52A1/SLC19A1/SLC38A2/GABRE/SLC22A11/GJA1/ANO6/SLC16A12/SLC1A5/SLC5A6/SLC38A9/SLC9A1/ANKH/SERINC3/SLC35D1/SLC16A1/SLC4A2/VDAC1/SLC38A1/SLC7A2/SLC1A3/SLC35B4/CLCN3/SLC13A3/SLC29A1/CLDN4/SLC27A6/SLC52A2/SLC2A8/CLIC3	34
GO:0004197	cysteine-type endopeptidase activity	17/1123	119/18367	0.000908988429892547	0.0221321002577362	LGMN/CTSC/CTSB/CTSD/USP25/USP47/USP9X/CTSF/GPAA1/PDIA3/USP34/CTSO/SENP6/USP12/CFLAR/CAPN7/USP10	17
GO:0008514	organic anion transmembrane transporter activity	23/1123	185/18367	0.000940076565995459	0.0221321002577362	SLC26A2/SLC2A1/SLC52A1/SLC19A1/SLC38A2/SLC22A11/GJA1/SLC16A12/SLC1A5/SLC5A6/SLC38A9/SERINC3/SLC35D1/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC35B4/SLC13A3/SLC29A1/SLC27A6/SLC52A2/SLC2A8	23
GO:0048027	mRNA 5'-UTR binding	7/1123	27/18367	0.000943259990194579	0.0221321002577362	RPS3A/RPL5/RPL26/RPS13/MYH10/DHX36/NCL	7
GO:0016758	hexosyltransferase activity	24/1123	197/18367	0.000982455520071947	0.022502909769267	GALNT11/CHPF/AGL/EXTL2/RPN2/C1GALT1/GCNT2/HEXB/STT3B/HEXA/B4GALT1/B4GALT5/B3GNT2/B3GNT5/STT3A/GCNT4/B3GNT3/RPN1/TMTC3/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1	24
GO:0044548	S100 protein binding	5/1123	14/18367	0.00106482192275681	0.0238222951091175	AHNAK/IQGAP1/S100A11/ATP2A2/ANXA2	5
GO:0008375	acetylglucosaminyltransferase activity	9/1123	44/18367	0.00117429880689393	0.0256744420961809	EXTL2/GCNT2/HEXB/HEXA/B3GNT2/B3GNT5/GCNT4/B3GNT3/MGAT1	9
GO:0051082	unfolded protein binding	17/1123	122/18367	0.00120550459512747	0.025771009344725	LMAN1/NPM1/NACA/CANX/HSP90B1/PPIA/PTGES3/HSP90AB1/ERLEC1/HSPA5/SIL1/ERO1B/DNAJA1/TAPBP/HSPA1A/HSPE1/CCT3	17
GO:0030695	GTPase regulator activity	47/1123	488/18367	0.00137423474795335	0.028127953777258	IQGAP2/IQGAP1/NRP1/HACD3/ARHGAP5/MYCBP2/ADRB1/PLXNB1/NF1/DOCK8/ARHGAP21/GNAQ/CHML/RASA1/RANBP2/ARFGEF1/NET1/ARHGAP18/AKAP13/ARHGAP28/DOCK9/DENND4C/GAPVD1/EVI5/ARHGAP29/ARFGEF3/C9orf72/WASL/RAB3GAP1/VAV3/ARHGAP32/IPO7/RAB3GAP2/RANBP1/ASAP1/ARHGAP23/ITSN2/CYTH3/SRGAP1/HERC2/TBC1D2B/RAPGEF2/EEF1D/EEF1B2/ARF4/RASGEF1B/CDC42SE1	47
GO:0060589	nucleoside-triphosphatase regulator activity	47/1123	488/18367	0.00137423474795335	0.028127953777258	IQGAP2/IQGAP1/NRP1/HACD3/ARHGAP5/MYCBP2/ADRB1/PLXNB1/NF1/DOCK8/ARHGAP21/GNAQ/CHML/RASA1/RANBP2/ARFGEF1/NET1/ARHGAP18/AKAP13/ARHGAP28/DOCK9/DENND4C/GAPVD1/EVI5/ARHGAP29/ARFGEF3/C9orf72/WASL/RAB3GAP1/VAV3/ARHGAP32/IPO7/RAB3GAP2/RANBP1/ASAP1/ARHGAP23/ITSN2/CYTH3/SRGAP1/HERC2/TBC1D2B/RAPGEF2/EEF1D/EEF1B2/ARF4/RASGEF1B/CDC42SE1	47
GO:0005520	insulin-like growth factor binding	7/1123	29/18367	0.00148939041545121	0.0286208262688008	LRP2/ITGA6/CRIM1/ITGB4/ITGAV/IGF1R/INSR	7
GO:0004559	alpha-mannosidase activity	5/1123	15/18367	0.00151732031154765	0.0286208262688008	EDEM3/MAN2A1/MAN1A2/MAN1C1/MAN1B1	5
GO:0005041	low-density lipoprotein particle receptor activity	5/1123	15/18367	0.00151732031154765	0.0286208262688008	LRP2/LRP1/OLR1/LRP10/VLDLR	5
GO:0042813	Wnt-activated receptor activity	5/1123	15/18367	0.00151732031154765	0.0286208262688008	LRP5/RYK/FZD5/FZD6/FZD3	5
GO:0072349	modified amino acid transmembrane transporter activity	6/1123	22/18367	0.00164662060023534	0.0304624811043538	SLC19A1/GJA1/SLC16A12/SLC5A6/SLC22A5/SLC13A3	6
GO:0046966	thyroid hormone receptor binding	7/1123	30/18367	0.00184149960361105	0.0330244910282834	NCOA3/NCOR1/NSD1/JMJD1C/MED13/TRIP12/FUS	7
GO:0043021	ribonucleoprotein complex binding	19/1123	149/18367	0.00187109573704174	0.0330244910282834	NEAT1/NPM1/RPN2/EIF1/SEC61A1/NEMF/SECISBP2L/RICTOR/HSPA5/RPSA/CPEB4/LTN1/CCDC47/EIF5A/SNRPD2/SND1/SNRPD1/SNRPB/YBX3	19
GO:0008013	beta-catenin binding	13/1123	85/18367	0.00188809460140913	0.0330244910282834	CDH1/KANK1/GJA1/TBL1X/DLG5/TCF7L2/DVL3/TBL1XR1/GLI3/PTPRK/SKP1/FOXO4/CTNNB1	13
GO:0061630	ubiquitin protein ligase activity	32/1123	304/18367	0.0019410710455529	0.0333448276039623	RNF43/MYCBP2/ZNRF3/RNF128/HECTD1/UBR5/NHLRC3/RNF13/RNF217/TRIM56/WWP1/UBR4/TRIM44/AMFR/TRIP12/LTN1/SIAH2/UBE4A/RBBP6/RNF19A/XIAP/RNF170/RNF167/UBE4B/TRIM38/SHPRH/UBR3/HERC2/SMURF2/RC3H1/TRIM13/UBE2C	32
GO:0022804	active transmembrane transporter activity	40/1123	406/18367	0.00200695277154894	0.0338717292321067	SLC26A2/ATP2B1/SLC13A4/ABCA1/SLC6A4/ATP2B4/SLC19A1/SLC38A2/SLC5A3/ATP13A3/SLC22A11/SLC16A12/COX6A1/SLC1A5/SLC17A5/SLC11A2/SLC5A6/SLC16A4/SLC9A1/ATP2A2/SLC7A6/ANKH/SLC28A2/LMBRD1/SLC22A5/SLC35D1/SLC16A1/SLC4A2/SLC38A1/SLC1A3/CLCN3/ATP1A1/SLC13A3/SLC22A18/ABCD3/SLC16A2/ATP7B/TAPBP/SLC35E1/UQCRH	40
GO:0017134	fibroblast growth factor binding	6/1123	23/18367	0.00211382879139733	0.0344661575817666	ITGAV/GLG1/RPS2/TGFBR3/GPC1/FGFR2	6
GO:0030215	semaphorin receptor binding	6/1123	23/18367	0.00211382879139733	0.0344661575817666	SEMA6D/SEMA6A/PLXNB1/SEMA3F/SEMA4B/SEMA7A	6
GO:0046943	carboxylic acid transmembrane transporter activity	20/1123	163/18367	0.00229462066920722	0.0367904180629558	SLC26A2/SLC27A2/SLC19A1/SLC38A2/SLC43A2/SLC16A12/SLC1A5/SLC38A10/SLC5A6/SLC16A4/SLC38A9/SLC7A6/SERINC3/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC13A3/SLC27A6/SLC16A2	20
GO:0005096	GTPase activator activity	44/1123	462/18367	0.00238065798237938	0.037544147197524	IQGAP2/IQGAP1/NRP1/HACD3/ARHGAP5/MYCBP2/ADRB1/PLXNB1/NF1/DOCK8/ARHGAP21/GNAQ/CHML/RASA1/RANBP2/ARFGEF1/NET1/ARHGAP18/AKAP13/ARHGAP28/DOCK9/DENND4C/GAPVD1/EVI5/ARHGAP29/ARFGEF3/C9orf72/RAB3GAP1/VAV3/ARHGAP32/RAB3GAP2/RANBP1/ASAP1/ARHGAP23/ITSN2/CYTH3/SRGAP1/HERC2/TBC1D2B/RAPGEF2/EEF1D/EEF1B2/ARF4/RASGEF1B	44
GO:0005342	organic acid transmembrane transporter activity	20/1123	164/18367	0.00246713429511088	0.0382803740628494	SLC26A2/SLC27A2/SLC19A1/SLC38A2/SLC43A2/SLC16A12/SLC1A5/SLC38A10/SLC5A6/SLC16A4/SLC38A9/SLC7A6/SERINC3/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC13A3/SLC27A6/SLC16A2	20
GO:0031625	ubiquitin protein ligase binding	31/1123	297/18367	0.00257740293216551	0.0387880405410342	EGFR/RPL23/RPL5/RTN4/ACTG1/ERBB3/HSP90AB1/USP25/YWHAE/ATF6/UBXN7/PCBP2/UBC/TPI1/FZD5/HSPA5/UBE2L3/LRPPRC/PIAS1/SLC22A18/SMAD2/FZD6/JKAMP/HM13/ABI2/SHPRH/DNAJA1/HERC2/HSPA1A/WFS1/LTBR	31
GO:0048306	calcium-dependent protein binding	13/1123	88/18367	0.00259177227786099	0.0387880405410342	ANXA1/S100P/ATP2B4/CALM1/S100A11/VLDLR/SLC9A1/SEC31A/S100A10/CLN3/ALG2/ANXA2/WFS1	13
GO:0019843	rRNA binding	11/1123	68/18367	0.00262081355006988	0.0387880405410342	RPL23A/RPL9/RPLP0/RPS11/RPL23/NPM1/RPL5/RPS3/RPS4X/RPS13/RPS9	11
GO:0050431	transforming growth factor beta binding	6/1123	24/18367	0.00267446532017572	0.0389823581516521	ITGAV/TGFBR3/LTBP1/LTBP3/TGFBR1/TSKU	6
GO:0070064	proline-rich region binding	5/1123	17/18367	0.00282230812339693	0.0399945395675916	PFN1/RABAC1/GAREM1/CCND1/ABI2	5
GO:0047485	protein N-terminus binding	15/1123	110/18367	0.00282705685093163	0.0399945395675916	NPM1/NIPBL/CALM1/NCOA3/RPS21/SMARCC1/RBPJ/TBL1XR1/MYO7A/ALG2/ACOX1/EIF5A/ATM/HSPA1A/MORF4L1	15
GO:0015293	symporter activity	18/1123	144/18367	0.00302833821554736	0.0422211791790806	SLC13A4/SLC6A4/SLC38A2/SLC5A3/SLC16A12/SLC1A5/SLC17A5/SLC11A2/SLC5A6/SLC16A4/SLC28A2/SLC22A5/SLC16A1/SLC38A1/SLC1A3/SLC13A3/SLC22A18/SLC16A2	18
GO:0097493	structural molecule activity conferring elasticity	4/1123	11/18367	0.00324157813021756	0.0445485451609899	FBN1/FBN2/AHNAK/LAMC1	4
GO:0004857	enzyme inhibitor activity	11/1123	70/18367	0.00331023870287122	0.0448514032698889	ANXA5/ANXA1/RPS20/RPL23/RPL5/DYNLL1/OAZ1/PPP1R12A/GCHFR/ANXA2/PPP1R12B	11
GO:0044389	ubiquitin-like protein ligase binding	32/1123	316/18367	0.00354760454295275	0.0473999384766742	EGFR/RPL23/RPL5/RTN4/ACTG1/ERBB3/HSP90AB1/USP25/YWHAE/ATF6/UBXN7/PCBP2/UBC/TPI1/FZD5/HSPA5/UBE2L3/LRPPRC/PIAS1/SLC22A18/SMAD2/FZD6/JKAMP/HM13/ABI2/SHPRH/DNAJA1/HERC2/UBE2C/HSPA1A/WFS1/LTBR	32
GO:0051015	actin filament binding	24/1123	217/18367	0.00360438946504145	0.0474989406215051	EGFR/SYNE2/UTRN/IQGAP2/IQGAP1/MACF1/SLC6A4/CFL1/SCIN/SPTBN1/MYO1C/ADD3/ACTN4/SPTAN1/FMNL2/FERMT1/PPP1R9A/DMD/TRPV4/MYH10/MYO7A/ARPC3/MYO6/DSTN	24
GO:0030228	lipoprotein particle receptor activity	5/1123	18/18367	0.00371327872626783	0.0482726234414819	LRP2/LRP1/OLR1/LRP10/VLDLR	5
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	4/1123	12/18367	0.00462891275366058	0.0578313515457334	CDK6/BRD4/CDK12/CDK13	4
GO:0031543	peptidyl-proline dioxygenase activity	4/1123	12/18367	0.00462891275366058	0.0578313515457334	P3H1/P3H2/P4HB/P4HTM	4
GO:0045295	gamma-catenin binding	4/1123	12/18367	0.00462891275366058	0.0578313515457334	CDH1/DSC3/TCF7L2/PTPRK	4
GO:0019955	cytokine binding	17/1123	139/18367	0.00486918111066474	0.0600532336981985	CSF3R/IL6ST/ITGB1/NRP2/ITGAV/NRP1/PRLR/CD74/TGFBR3/LTBP1/LIFR/LTBP3/TGFBR1/BMPR2/HMGB1/TSKU/BMPR1A	17
GO:0004190	aspartic-type endopeptidase activity	6/1123	27/18367	0.00502789481945246	0.0604604352039158	SPPL2A/CTSD/NCSTN/DDI2/SPPL2B/HM13	6
GO:0045499	chemorepellent activity	6/1123	27/18367	0.00502789481945246	0.0604604352039158	SEMA6D/SEMA6A/DPP4/SEMA3F/SEMA4B/SEMA7A	6
GO:0003725	double-stranded RNA binding	11/1123	74/18367	0.00512260467079514	0.0608388357198139	DICER1/HSP90AB1/CLTC/MBNL1/LRRFIP1/TFRC/DHX36/AGO2/HMGB1/TLR3/RC3H1	11
GO:0019208	phosphatase regulator activity	14/1123	107/18367	0.00559032161310122	0.0647938480940166	PHACTR2/BOD1L1/CALM1/PPP1R14B/PPP6R2/PPP1R12A/BMPR2/PPP6R3/PPP4R1/PPP1R15B/PHACTR4/BMPR1A/B3GAT3/PPP1R12B	14
GO:0051087	chaperone binding	14/1123	107/18367	0.00559032161310122	0.0647938480940166	LRP2/GRN/CTSC/PTGES3/SCARB2/FN1/HSPA5/AMFR/ATP1A1/DNAJC3/DNAJA1/BIRC5/HSPE1/SOD1	14
GO:0005516	calmodulin binding	22/1123	201/18367	0.00584664492266752	0.064924721090415	EGFR/ATP2B1/IQGAP2/IQGAP1/ATP2B4/EEA1/SPTBN1/MYO1C/PHKB/ADD3/SLC9A1/SYT7/SPTAN1/KCNN4/UBR4/TRPV4/MYH10/MYO7A/CAMSAP2/MYO6/PPP3CA/WFS1	22
GO:0008022	protein C-terminus binding	21/1123	189/18367	0.0058887101570075	0.064924721090415	BCAM/FBLN1/NIPBL/DST/TBL1X/PRRC2C/MYO1C/DLG1/FN1/FIGN/TOP2B/PPP1R9A/PIAS1/AGO2/RABAC1/SREBF2/NCL/ERBB2/CTNNB1/CDC20/PRDX3	21
GO:0019211	phosphatase activator activity	5/1123	20/18367	0.00606858753262777	0.064924721090415	CALM1/BMPR2/PHACTR4/BMPR1A/B3GAT3	5
GO:0030506	ankyrin binding	5/1123	20/18367	0.00606858753262777	0.064924721090415	CDH1/PLEC/NRCAM/SPTBN1/ATP1A1	5
GO:0015101	organic cation transmembrane transporter activity	6/1123	28/18367	0.00607403835565213	0.064924721090415	ATP13A3/SLC44A2/SLC19A3/SLC22A5/SLC44A1/SLC29A1	6
GO:0043236	laminin binding	6/1123	28/18367	0.00607403835565213	0.064924721090415	ITGA6/DAG1/ITGB1/BCAM/GPC1/RPSA	6
GO:0070001	aspartic-type peptidase activity	6/1123	28/18367	0.00607403835565213	0.064924721090415	SPPL2A/CTSD/NCSTN/DDI2/SPPL2B/HM13	6
GO:0034450	ubiquitin-ubiquitin ligase activity	4/1123	13/18367	0.00636592171177654	0.067296886667352	UBR5/AMFR/UBE4A/UBE4B	4
GO:0050840	extracellular matrix binding	9/1123	56/18367	0.00651401243287063	0.0681139126132776	ITGA6/DAG1/ADGRG1/ITGB1/BCAM/ITGAV/GPC1/RPSA/ANXA2	9
GO:0015662	P-type ion transporter activity	5/1123	21/18367	0.00757058720198899	0.0774777115778022	ATP2B1/ATP2B4/ATP2A2/ATP1A1/ATP7B	5
GO:0140358	P-type transmembrane transporter activity	5/1123	21/18367	0.00757058720198899	0.0774777115778022	ATP2B1/ATP2B4/ATP2A2/ATP1A1/ATP7B	5
GO:0051117	ATPase binding	12/1123	89/18367	0.00782431567625501	0.0792314913742875	EGFR/ABCA1/USP25/TMEM106B/NCSTN/CAV1/UBE4B/TOR1AIP2/PKD2/PPP3CA/ATP6V0A1/WFS1	12
GO:0015026	coreceptor activity	8/1123	48/18367	0.00808767211325151	0.0810452143015411	LRP1/ITGB1/ITGAV/LRP5/NRP1/TGFBR3/RYK/PTK7	8
GO:0016757	glycosyltransferase activity	27/1123	270/18367	0.00822967166774794	0.0816179808698301	GALNT11/CHPF/AGL/EXTL2/RPN2/GXYLT1/C1GALT1/GCNT2/HEXB/STT3B/HEXA/B4GALT1/B4GALT5/B3GNT2/B3GNT5/TNKS2/STT3A/PARP14/GCNT4/B3GNT3/RPN1/TMTC3/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1	27
GO:0002020	protease binding	16/1123	135/18367	0.008331729036611	0.0816364767859033	ADAMTSL4/LRP1/ITGB1/ITGAV/PSAP/DPP4/FURIN/CLTC/FN1/UBC/DVL3/AMFR/CFLAR/SH3PXD2A/ANXA2/SERPINB9	16
GO:0046332	SMAD binding	11/1123	79/18367	0.00840125904553475	0.0816364767859033	TGFBR3/USP9X/COL5A2/TGFBR1/TRIM33/PURB/SMAD2/IPO7/BMPR1A/SMURF2/CTNNB1	11
GO:0015926	glucosidase activity	4/1123	14/18367	0.00848636162738445	0.0816387988554384	AGL/GANAB/GAA/MOGS	4
GO:0017147	Wnt-protein binding	6/1123	30/18367	0.0086271669372062	0.0821716296395283	LRP5/WLS/RYK/FZD5/FZD6/FZD3	6
GO:0004175	endopeptidase activity	39/1123	430/18367	0.00901140963111069	0.0849899614228283	ADAMTS6/MME/LGMN/SPPL2A/CTSC/DPP4/PRSS8/CTSB/CTSD/FURIN/YME1L1/USP25/ADAM10/USP47/ST14/USP9X/ADAMTS1/CTSF/GPAA1/PDIA3/USP34/TPP1/PCSK7/NCSTN/CTSO/MMP15/ADAM17/SENP6/USP12/DDI2/ADAMTS19/PRSS12/SPPL2B/CFLAR/CAPN7/HM13/ERAP1/USP10/PSMB5	39
GO:0055106	ubiquitin-protein transferase regulator activity	5/1123	22/18367	0.00931293032015186	0.0861446054614047	RPS20/RPL23/RPL5/UBE2L3/CDC20	5
GO:0070034	telomerase RNA binding	5/1123	22/18367	0.00931293032015186	0.0861446054614047	XRN1/DHX36/DCP2/HNRNPC/SNRPB	5
GO:0004177	aminopeptidase activity	7/1123	40/18367	0.00991110522454839	0.0899479549624109	DPP4/ENPEP/LNPEP/NPEPPS/MMP15/DPP7/ERAP1	7
GO:0044183	protein folding chaperone	7/1123	40/18367	0.00991110522454839	0.0899479549624109	CD74/HSP90AB1/HSPA5/HSPB1/CCDC47/HSPA1A/CCT3	7
GO:0001786	phosphatidylserine binding	9/1123	60/18367	0.0102306611884614	0.0919803370401855	MME/SCIN/SCARB2/SYT7/HMGB1/OSBPL8/ASAP1/APPL1/ANXA2	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	8/1123	50/18367	0.0103367423882268	0.0920735757173531	SLC19A1/SLC28A2/SLC35D1/SLC35B4/SLC25A36/SLC29A1/SLC29A3/HNRNPA3	8
GO:0140297	DNA-binding transcription factor binding	36/1123	394/18367	0.0105559560626901	0.09316357552576	PTMA/NPM1/NCOA3/TACC2/RPS3/NCOR1/ACTN4/TCERG1/NSD1/GTF2I/TCF7L2/JMJD1C/ARID1A/MED13/CHCHD2/TRIP12/RBPJ/HSPB1/TLE4/PURB/FOXP1/SPEN/SMAD2/HMGB1/NCOA2/MAPK14/ACTB/REST/ISL1/DNAJA1/FOXO4/TDG/CREBBP/CTNNB1/WFS1/FUS	36
GO:0048029	monosaccharide binding	10/1123	71/18367	0.0108118725279859	0.0945547397447494	LMAN1/COLEC12/ALDOA/MANBA/P3H1/P3H2/CLN5/PLOD1/SLC2A8/P4HTM	10
GO:0072341	modified amino acid binding	12/1123	93/18367	0.0109979694430808	0.094658725425586	MME/SLC19A1/SCIN/SCARB2/FOLR1/SYT7/HMGB1/OSBPL8/ASAP1/APPL1/ANXA2/FASN	12
GO:0015929	hexosaminidase activity	4/1123	15/18367	0.0110205584695069	0.094658725425586	HEXB/HEXA/GM2A/NAGLU	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	7/1123	41/18367	0.0113369093941044	0.0959368418407727	SLC27A2/ACSS1/AASDH/SLC27A6/UBA1/ACSL3/UBA6	7
GO:0015179	L-amino acid transmembrane transporter activity	9/1123	61/18367	0.011368814937472	0.0959368418407727	SLC38A2/SLC43A2/SLC1A5/SLC38A9/SLC7A6/SERINC3/SLC38A1/SLC7A2/SLC1A3	9
GO:0140678	molecular function inhibitor activity	15/1123	128/18367	0.0115010013334544	0.0962083763720275	ANXA5/ANXA1/RPS20/RPL23/RPL5/DYNLL1/OAZ1/CALM1/RASA1/PPP1R12A/WNK1/GCHFR/CAV1/ANXA2/PPP1R12B	15
GO:0008378	galactosyltransferase activity	6/1123	32/18367	0.0118689039710707	0.0984300484497415	C1GALT1/B4GALT1/B4GALT5/B3GNT2/B3GNT5/B3GNT3	6
GO:0005543	phospholipid binding	41/1123	466/18367	0.0122678419110042	0.100868922379368	ANXA5/MME/ANXA1/PFN1/PSAP/IQGAP2/IQGAP1/ABCA1/SCIN/NF1/EEA1/SNX13/SPTBN1/ITPR2/SNX18/SCARB2/SLC9A1/SYT7/JAG1/SNX14/GPAA1/VDAC1/PRKCI/TPP1/MTSS1/TTPA/PLEKHA8/NISCH/ARHGAP32/WDFY3/HMGB1/OSBPL8/ASAP1/SH3PXD2A/APPL1/MYOF/ANXA2/CYTH3/EPN3/ESYT2/RAPGEF2	41
GO:0008234	cysteine-type peptidase activity	20/1123	190/18367	0.0125156971432066	0.102034751286142	LGMN/CTSC/CTSB/CTSD/USP25/USP47/USP9X/CTSF/GPAA1/PDIA3/USP34/CTSO/SENP6/USP12/CFLAR/CAPN7/GGH/USP10/EIF3H/USP43	20
GO:0022853	active ion transmembrane transporter activity	26/1123	267/18367	0.0129397131452595	0.104605076014619	SLC26A2/ATP2B1/SLC13A4/SLC6A4/ATP2B4/SLC19A1/SLC38A2/SLC5A3/ATP13A3/SLC22A11/COX6A1/SLC17A5/SLC11A2/SLC5A6/SLC9A1/ATP2A2/SLC28A2/SLC4A2/SLC38A1/SLC1A3/CLCN3/ATP1A1/SLC13A3/SLC22A18/ATP7B/UQCRH	26
GO:0015171	amino acid transmembrane transporter activity	11/1123	84/18367	0.0131110507156749	0.105106923237327	SLC38A2/SLC43A2/SLC1A5/SLC38A10/SLC38A9/SLC7A6/SERINC3/SLC38A1/SLC7A2/SLC1A3/SLC16A2	11
GO:0019887	protein kinase regulator activity	21/1123	204/18367	0.0135287728575536	0.107559334619558	IQGAP1/NPM1/CALM1/ERBB3/HSP90AB1/TAOK1/KIDINS220/RICTOR/PKIB/WNK1/BMPR2/DNAJC3/HSPB1/TAOK3/HMGB1/CCND1/BMPR1A/EFNA5/IBTK/CKS1B/CDKN1C	21
GO:0061134	peptidase regulator activity	23/1123	230/18367	0.0139494448774046	0.109994803049699	GAPDH/SPINT1/CRIM1/ITIH5/APLP2/FBLN1/APP/CTSC/TFPI/SERPINF1/FURIN/BIRC6/FN1/ROCK1/CAV1/CAST/XIAP/ANXA2/SERPINB9/GPC3/BIRC5/PRDX3/SERPINB1	23
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	8/1123	54/18367	0.0161765969556616	0.126519400580052	ASPH/P3H1/TET2/P3H2/P4HB/KDM5A/PLOD1/P4HTM	8
GO:0019902	phosphatase binding	20/1123	196/18367	0.0171070101304386	0.129003845228276	EGFR/MET/IQGAP1/HSP90B1/ATP2B4/CTSC/BOD1L1/SLC9A1/DLG1/KCNN4/PPP1R9A/PPP6R2/WNK1/PPP6R3/SMAD2/MAPK14/PHACTR4/ERBB2/CTNNB1/SOD1	20
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	4/1123	17/18367	0.0174329520578751	0.129003845228276	PTPRF/PTPRA/PTPRM/PTPRK	4
GO:0005324	long-chain fatty acid transporter activity	4/1123	17/18367	0.0174329520578751	0.129003845228276	SLC2A1/SLC27A2/SLC27A6/ABCD3	4
GO:0008381	mechanosensitive ion channel activity	4/1123	17/18367	0.0174329520578751	0.129003845228276	TMEM150C/TMC5/TRPV4/TMEM63A	4
GO:0019198	transmembrane receptor protein phosphatase activity	4/1123	17/18367	0.0174329520578751	0.129003845228276	PTPRF/PTPRA/PTPRM/PTPRK	4
GO:0034185	apolipoprotein binding	4/1123	17/18367	0.0174329520578751	0.129003845228276	LRP1/ABCA1/CANX/VLDLR	4
GO:0048531	beta-1,3-galactosyltransferase activity	4/1123	17/18367	0.0174329520578751	0.129003845228276	C1GALT1/B3GNT2/B3GNT5/B3GNT3	4
GO:0005085	guanyl-nucleotide exchange factor activity	22/1123	223/18367	0.0183561592795448	0.134798665854367	MYCBP2/ADRB1/DOCK8/ARFGEF1/NET1/AKAP13/DOCK9/DENND4C/GAPVD1/ARFGEF3/C9orf72/RAB3GAP1/VAV3/RAB3GAP2/ITSN2/CYTH3/HERC2/RAPGEF2/EEF1D/EEF1B2/ARF4/RASGEF1B	22
GO:0004714	transmembrane receptor protein tyrosine kinase activity	14/1123	124/18367	0.0192959733765172	0.138878295435842	EGFR/CRIM1/MET/NRP2/EFEMP1/FLT1/NRP1/IGF1R/ERBB3/EPHB4/DDR1/INSR/FGFR2/ERBB2	14
GO:0008172	S-methyltransferase activity	3/1123	10/18367	0.0197778861483475	0.138878295435842	DNMT3A/MTR/KMT2A	3
GO:0008239	dipeptidyl-peptidase activity	3/1123	10/18367	0.0197778861483475	0.138878295435842	CTSC/DPP4/DPP7	3
GO:0017002	activin-activated receptor activity	3/1123	10/18367	0.0197778861483475	0.138878295435842	TGFBR1/BMPR2/ACVR2B	3
GO:0030957	Tat protein binding	3/1123	10/18367	0.0197778861483475	0.138878295435842	NPM1/ACTB/DNAJA1	3
GO:0070008	serine-type exopeptidase activity	3/1123	10/18367	0.0197778861483475	0.138878295435842	CPD/TPP1/CTSA	3
GO:0097110	scaffold protein binding	9/1123	67/18367	0.0202773116799382	0.141353433594931	IL6ST/KRT8/PSAP/ATP2B4/DYNLL1/KRT18/ITPR2/YWHAE/DSP	9
GO:0030414	peptidase inhibitor activity	19/1123	187/18367	0.0205721802190637	0.142377247271505	GAPDH/SPINT1/CRIM1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/BIRC6/ROCK1/CAST/XIAP/ANXA2/SERPINB9/GPC3/BIRC5/PRDX3/SERPINB1	19
GO:0033218	amide binding	35/1123	400/18367	0.0210221468740172	0.144452180662889	LRP1/SLC40A1/MME/PSAP/IGF1R/PRLR/SLC19A1/CD74/NKTR/PPIA/ENPEP/FURIN/HSP90AB1/TNPO1/LNPEP/FOLR1/SEC61A1/ITM2B/FZD5/CLSTN1/VDAC1/PPIG/TPP1/NPEPPS/KPNB1/PLEKHA8/CLTA/DHCR24/EDNRB/INSR/PPP3CA/ERAP1/CAT/TAPBP/FASN	35
GO:0019903	protein phosphatase binding	16/1123	150/18367	0.0212468529456214	0.144658099243203	EGFR/MET/IQGAP1/HSP90B1/ATP2B4/BOD1L1/SLC9A1/KCNN4/PPP1R9A/PPP6R2/PPP6R3/MAPK14/PHACTR4/ERBB2/CTNNB1/SOD1	16
GO:0098641	cadherin binding involved in cell-cell adhesion	4/1123	18/18367	0.0213528587240487	0.144658099243203	ANXA1/S100A11/KRT18/ANXA2	4
GO:0070006	metalloaminopeptidase activity	5/1123	27/18367	0.0221891403059483	0.148235784543904	ENPEP/LNPEP/NPEPPS/MMP15/ERAP1	5
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	5/1123	27/18367	0.0221891403059483	0.148235784543904	ATP10D/ABCA1/TMEM30A/TMEM30B/ATP11B	5
GO:0042277	peptide binding	29/1123	321/18367	0.0230601471039017	0.152992148372093	LRP1/SLC40A1/MME/IGF1R/PRLR/CD74/NKTR/PPIA/ENPEP/FURIN/HSP90AB1/TNPO1/LNPEP/SEC61A1/ITM2B/FZD5/CLSTN1/PPIG/TPP1/NPEPPS/KPNB1/CLTA/DHCR24/EDNRB/INSR/PPP3CA/ERAP1/CAT/TAPBP	29
GO:0005518	collagen binding	9/1123	69/18367	0.0241363504176665	0.159035404806816	ADGRG1/ITGB1/COL14A1/CTSB/P3H1/FN1/CRTAP/DDR1/C1QTNF1	9
GO:0008201	heparin binding	17/1123	166/18367	0.0256318424391785	0.159183436893316	FBN1/ADGRG1/NRP2/FSTL1/PTPRF/APLP2/NRP1/APP/TGFBR3/BMP7/CCDC80/FN1/ADAMTS1/AOC1/ZNF207/FGFR2/NAV2	17
GO:0003785	actin monomer binding	5/1123	28/18367	0.0256924233386213	0.159183436893316	PFN1/COBLL1/MTSS1/TMSB4X/COBL	5
GO:0051861	glycolipid binding	5/1123	28/18367	0.0256924233386213	0.159183436893316	PSAP/GPAA1/TPP1/PLEKHA8/CLN3	5
GO:0003746	translation elongation factor activity	4/1123	19/18367	0.0257698836425621	0.159183436893316	EEF1A1/EIF5A/EEF1D/EEF1B2	4
GO:0002162	dystroglycan binding	3/1123	11/18367	0.0259790016551462	0.159183436893316	DAG1/PLEC/DMD	3
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	3/1123	11/18367	0.0259790016551462	0.159183436893316	PCYOX1/P4HB/ERO1B	3
GO:0022889	serine transmembrane transporter activity	3/1123	11/18367	0.0259790016551462	0.159183436893316	SLC38A2/SLC1A5/SERINC3	3
GO:0046975	histone methyltransferase activity (H3-K36 specific)	3/1123	11/18367	0.0259790016551462	0.159183436893316	ASH1L/NSD1/SETD2	3
GO:0047676	arachidonate-CoA ligase activity	3/1123	11/18367	0.0259790016551462	0.159183436893316	SLC27A2/SLC27A6/ACSL3	3
GO:0061665	SUMO ligase activity	3/1123	11/18367	0.0259790016551462	0.159183436893316	RANBP2/ZNF451/PIAS1	3
GO:0099186	structural constituent of postsynapse	3/1123	11/18367	0.0259790016551462	0.159183436893316	ACTG1/DLG1/ACTB	3
GO:0015175	neutral amino acid transmembrane transporter activity	6/1123	38/18367	0.0265380007126806	0.159559729284992	SLC38A2/SLC43A2/SLC1A5/SLC38A9/SERINC3/SLC38A1	6
GO:0044390	ubiquitin-like protein conjugating enzyme binding	6/1123	38/18367	0.0265380007126806	0.159559729284992	RPS3/TCERG1/RNF217/SIAH2/ZMYM2/RNF19A	6
GO:0140303	intramembrane lipid transporter activity	6/1123	38/18367	0.0265380007126806	0.159559729284992	ATP10D/ABCA1/ANO6/TMEM30A/TMEM30B/ATP11B	6
GO:0004866	endopeptidase inhibitor activity	18/1123	180/18367	0.0273189174482143	0.163234773821007	GAPDH/SPINT1/CRIM1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/BIRC6/ROCK1/CAST/XIAP/ANXA2/SERPINB9/BIRC5/PRDX3/SERPINB1	18
GO:0043539	protein serine/threonine kinase activator activity	7/1123	49/18367	0.0284614655452862	0.168412158866161	IQGAP1/CALM1/TAOK1/RICTOR/BMPR2/BMPR1A/CKS1B	7
GO:0019207	kinase regulator activity	22/1123	233/18367	0.0285448254427804	0.168412158866161	IQGAP1/NPM1/CALM1/ERBB3/HSP90AB1/TAOK1/KIDINS220/GSTP1/RICTOR/PKIB/WNK1/BMPR2/DNAJC3/HSPB1/TAOK3/HMGB1/CCND1/BMPR1A/EFNA5/IBTK/CKS1B/CDKN1C	22
GO:0008194	UDP-glycosyltransferase activity	15/1123	143/18367	0.0287105967297821	0.168412158866161	GALNT11/CHPF/EXTL2/GXYLT1/GCNT2/HEXB/HEXA/B4GALT1/B4GALT5/B3GNT2/B3GNT5/GCNT4/B3GNT3/B3GAT3/MGAT1	15
GO:0035250	UDP-galactosyltransferase activity	5/1123	29/18367	0.029530421227816	0.170631920808831	B4GALT1/B4GALT5/B3GNT2/B3GNT5/B3GNT3	5
GO:0050997	quaternary ammonium group binding	6/1123	39/18367	0.0297957122640603	0.170631920808831	ABCA1/NF1/SCARB2/VDAC1/ESYT2/TKT	6
GO:0016922	nuclear receptor binding	15/1123	144/18367	0.0303107076238792	0.170631920808831	NCOA3/TACC2/NCOR1/ACTN4/NSD1/TCF7L2/JMJD1C/ARID1A/MED13/TRIP12/FOXP1/NCOA2/ISL1/CTNNB1/FUS	15
GO:0003756	protein disulfide isomerase activity	4/1123	20/18367	0.0306952076700457	0.170631920808831	P4HB/PDIA3/PDIA4/ERO1B	4
GO:0016018	cyclosporin A binding	4/1123	20/18367	0.0306952076700457	0.170631920808831	NKTR/PPIA/PPIG/PPP3CA	4
GO:0016500	protein-hormone receptor activity	4/1123	20/18367	0.0306952076700457	0.170631920808831	LGR5/LGR4/IGF1R/INSR	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4/1123	20/18367	0.0306952076700457	0.170631920808831	P4HB/PDIA3/PDIA4/ERO1B	4
GO:0031418	L-ascorbic acid binding	4/1123	20/18367	0.0306952076700457	0.170631920808831	P3H1/P3H2/PLOD1/P4HTM	4
GO:0008235	metalloexopeptidase activity	9/1123	72/18367	0.030862738275194	0.170631920808831	CPD/ENPEP/LNPEP/CPM/TFRC/NPEPPS/MMP15/NAALADL2/ERAP1	9
GO:0030276	clathrin binding	9/1123	72/18367	0.030862738275194	0.170631920808831	LRP1/STON1/CLTC/SYT7/LMBRD1/CLTA/DNAJC6/AP2A2/EPN3	9
GO:0008135	translation factor activity, RNA binding	10/1123	84/18367	0.0318976788161876	0.175346097263843	EEF1A1/EIF1/EIF3A/CPEB4/AGO2/EIF5A/EIF2S2/EEF1D/EIF3H/EEF1B2	10
GO:0090079	translation regulator activity, nucleic acid binding	12/1123	108/18367	0.0321984524282851	0.175993813840968	EEF1A1/EIF1/EIF3A/CPEB4/CELF1/AGO2/EIF5A/EIF2S2/PAIP2/EEF1D/EIF3H/EEF1B2	12
GO:0016853	isomerase activity	16/1123	158/18367	0.0325434648891532	0.176874650979466	MIF/NKTR/PPIA/PTGES3/DSE/TPI1/P4HB/PPIG/PDIA3/TOP2B/DEGS1/GNE/PDIA4/FKBP14/ERO1B/ISYNA1	16
GO:0005095	GTPase inhibitor activity	3/1123	12/18367	0.0330956979556414	0.176878119074039	IQGAP2/IQGAP1/CDC42SE1	3
GO:0017166	vinculin binding	3/1123	12/18367	0.0330956979556414	0.176878119074039	DAG1/UTRN/DMD	3
GO:0070410	co-SMAD binding	3/1123	12/18367	0.0330956979556414	0.176878119074039	USP9X/TRIM33/SMAD2	3
GO:0015370	solute:sodium symporter activity	9/1123	73/18367	0.0333685433790244	0.177351042710616	SLC13A4/SLC6A4/SLC38A2/SLC5A3/SLC5A6/SLC28A2/SLC38A1/SLC1A3/SLC13A3	9
GO:0004601	peroxidase activity	7/1123	51/18367	0.0345606029849197	0.181679235363348	PRDX1/PRDX4/GPX3/GSTP1/GPX8/CAT/PRDX3	7
GO:0016860	intramolecular oxidoreductase activity	7/1123	51/18367	0.0345606029849197	0.181679235363348	MIF/PTGES3/TPI1/P4HB/PDIA3/PDIA4/ERO1B	7
GO:0017022	myosin binding	9/1123	74/18367	0.0360113858518972	0.18808029501612	MYL12B/ARFGEF1/RAB6A/TRPM7/DMD/VEZT/TRAK2/RHOA/FUS	9
GO:1901981	phosphatidylinositol phosphate binding	17/1123	173/18367	0.0361692875031	0.18808029501612	PFN1/IQGAP2/IQGAP1/SCIN/SNX13/SNX18/SLC9A1/SYT7/SNX14/TTPA/PLEKHA8/ARHGAP32/OSBPL8/ASAP1/SH3PXD2A/ANXA2/CYTH3	17
GO:0004867	serine-type endopeptidase inhibitor activity	11/1123	98/18367	0.0367844922938045	0.190250976272258	SPINT1/CRIM1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/ANXA2/SERPINB9/SERPINB1	11
GO:0000146	microfilament motor activity	5/1123	31/18367	0.0382407930238063	0.192605460151318	MYO1C/MYH10/MYO7A/MYO6/MYL6	5
GO:0016878	acid-thiol ligase activity	5/1123	31/18367	0.0382407930238063	0.192605460151318	SLC27A2/ACSS1/AASDH/SLC27A6/ACSL3	5
GO:0031210	phosphatidylcholine binding	5/1123	31/18367	0.0382407930238063	0.192605460151318	ABCA1/NF1/SCARB2/VDAC1/ESYT2	5
GO:0140142	nucleocytoplasmic carrier activity	5/1123	31/18367	0.0382407930238063	0.192605460151318	TNPO1/KPNB1/RAN/RANBP17/IPO9	5
GO:0140318	protein transporter activity	5/1123	31/18367	0.0382407930238063	0.192605460151318	LRP2/IGF1R/ABCA1/SEC63/SEC61A1	5
GO:0004713	protein tyrosine kinase activity	14/1123	136/18367	0.0387144223781134	0.193975387123672	EGFR/CRIM1/MET/NRP2/EFEMP1/FLT1/NRP1/IGF1R/ERBB3/EPHB4/DDR1/INSR/FGFR2/ERBB2	14
GO:0003727	single-stranded RNA binding	10/1123	87/18367	0.0393124509739202	0.195951180502131	HNRNPA1/ANXA1/MSI2/HNRNPH1/LARP4/RBMS3/AGO2/HMGB1/HNRNPC/L1TD1	10
GO:0001046	core promoter sequence-specific DNA binding	6/1123	42/18367	0.0410982200380529	0.200772968818814	NPM1/NR3C1/KLF10/FOXP1/AGO2/REST	6
GO:0008307	structural constituent of muscle	6/1123	42/18367	0.0410982200380529	0.200772968818814	DAG1/KRT19/ASPH/PLEC/DMD/MYL6	6
GO:0004859	phospholipase inhibitor activity	3/1123	13/18367	0.0411146308288009	0.200772968818814	ANXA5/ANXA1/ANXA2	3
GO:0072542	protein phosphatase activator activity	3/1123	13/18367	0.0411146308288009	0.200772968818814	CALM1/PHACTR4/B3GAT3	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	7/1123	53/18367	0.0414688471131585	0.201479954155851	SLC19A1/SLC17A5/SLC28A2/SLC35D1/SLC35B4/SLC29A1/SLC29A3	7
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/1123	22/18367	0.0420970425098554	0.203504295952165	XIAP/SERPINB9/BIRC5/PRDX3	4
GO:0005539	glycosaminoglycan binding	21/1123	230/18367	0.0432989096827458	0.208267755574007	FBN1/ADGRG1/NRP2/FSTL1/PTPRF/APLP2/EXTL2/NRP1/GNS/APP/PPIA/TGFBR3/BMP7/CCDC80/FN1/ADAMTS1/AOC1/ZNF207/FGFR2/NAV2/HMMR	21
GO:0035091	phosphatidylinositol binding	24/1123	271/18367	0.0439094030053859	0.210153461150155	PFN1/IQGAP2/IQGAP1/SCIN/EEA1/SNX13/ITPR2/SNX18/SLC9A1/SYT7/SNX14/GPAA1/TTPA/PLEKHA8/NISCH/ARHGAP32/WDFY3/OSBPL8/ASAP1/SH3PXD2A/APPL1/ANXA2/CYTH3/ESYT2	24
GO:0030295	protein kinase activator activity	11/1123	101/18367	0.044336072947358	0.211145060274052	IQGAP1/CALM1/ERBB3/TAOK1/RICTOR/WNK1/BMPR2/HMGB1/BMPR1A/EFNA5/CKS1B	11
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	26/1123	299/18367	0.0448049509093492	0.211577788705837	NPM1/NCOA3/TACC2/NCOR1/ACTN4/TCERG1/NSD1/GTF2I/TCF7L2/JMJD1C/ARID1A/MED13/TRIP12/RBPJ/HSPB1/FOXP1/SPEN/NCOA2/MAPK14/ACTB/REST/ISL1/DNAJA1/CREBBP/CTNNB1/FUS	26
GO:0019888	protein phosphatase regulator activity	10/1123	89/18367	0.0448668075841899	0.211577788705837	PHACTR2/BOD1L1/CALM1/PPP1R14B/PPP6R2/PPP6R3/PPP4R1/PPP1R15B/PHACTR4/B3GAT3	10
GO:0015459	potassium channel regulator activity	7/1123	54/18367	0.0452357779876793	0.212277163044622	AKAP9/SLC5A3/RASA1/YWHAE/DLG1/WNK1/CAV1	7
GO:0042826	histone deacetylase binding	13/1123	127/18367	0.0469505150827066	0.219254347133805	NIPBL/HSP90AB1/PKN2/YWHAE/NCOR1/TOP2B/MIER1/GLI3/DHX36/CCND1/CDC20/HSPA1A/HNRNPD	13
GO:0043022	ribosome binding	8/1123	66/18367	0.0472952136300805	0.21979707976878	RPN2/SEC61A1/RICTOR/HSPA5/RPSA/CPEB4/CCDC47/EIF5A	8
GO:0045182	translation regulator activity	14/1123	140/18367	0.0475335441854917	0.219842641857899	EEF1A1/EIF1/IREB2/EIF3A/CPEB4/RPS9/CELF1/AGO2/EIF5A/EIF2S2/PAIP2/EEF1D/EIF3H/EEF1B2	14
GO:0005158	insulin receptor binding	4/1123	23/18367	0.0485779607761817	0.222533325079461	IGF1R/LMBRD1/PHIP/SORBS1	4
GO:0140103	catalytic activity, acting on a glycoprotein	4/1123	23/18367	0.0485779607761817	0.222533325079461	C1GALT1/GCNT4/B3GNT3/MGAT1	4
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	7/1123	55/18367	0.0492153225205399	0.222988794380341	PRDX1/PRDX4/GPX3/GSTP1/GPX8/CAT/PRDX3	7
GO:0005200	structural constituent of cytoskeleton	11/1123	103/18367	0.0499230694041758	0.222988794380341	KRT19/ACTG1/ANK3/PLEC/SPTBN1/ADD3/SPTAN1/DMD/DSP/ARPC3/ACTB	11
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	3/1123	14/18367	0.0500132497019144	0.222988794380341	B3GNT2/B3GNT5/B3GNT3	3
GO:0043023	ribosomal large subunit binding	3/1123	14/18367	0.0500132497019144	0.222988794380341	NPM1/NEMF/LTN1	3
GO:0070411	I-SMAD binding	3/1123	14/18367	0.0500132497019144	0.222988794380341	TGFBR1/SMAD2/CTNNB1	3
GO:0005319	lipid transporter activity	15/1123	154/18367	0.0500681700479768	0.222988794380341	SLC2A1/ATP10D/ABCA1/SLC27A2/ANO6/TMEM30A/GM2A/NPC1/TTPA/PLEKHA8/SLC27A6/OSBPL8/ABCD3/TMEM30B/ATP11B	15
GO:0061135	endopeptidase regulator activity	18/1123	194/18367	0.0511037235423437	0.226551991003386	GAPDH/SPINT1/CRIM1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/BIRC6/ROCK1/CAST/XIAP/ANXA2/SERPINB9/BIRC5/PRDX3/SERPINB1	18
GO:0015294	solute:cation symporter activity	11/1123	104/18367	0.0528872144652626	0.233383028970562	SLC13A4/SLC6A4/SLC38A2/SLC5A3/SLC17A5/SLC11A2/SLC5A6/SLC28A2/SLC38A1/SLC1A3/SLC13A3	11
GO:0043548	phosphatidylinositol 3-kinase binding	5/1123	34/18367	0.053965742450058	0.23705499651578	IGF1R/CALM1/ATP1A1/PIK3IP1/INSR	5
GO:0048156	tau protein binding	6/1123	45/18367	0.0547862122339736	0.239565164404921	LGMN/HSP90AB1/TAOK1/ROCK1/SMAD2/ACTB	6
GO:0004467	long-chain fatty acid-CoA ligase activity	3/1123	15/18367	0.0597614225100163	0.255081666701897	SLC27A2/SLC27A6/ACSL3	3
GO:0005545	1-phosphatidylinositol binding	3/1123	15/18367	0.0597614225100163	0.255081666701897	SCIN/EEA1/WDFY3	3
GO:0032794	GTPase activating protein binding	3/1123	15/18367	0.0597614225100163	0.255081666701897	CDH1/PLXNB1/GAPVD1	3
GO:0048185	activin binding	3/1123	15/18367	0.0597614225100163	0.255081666701897	TGFBR3/TGFBR1/ACVR2B	3
GO:1904680	peptide transmembrane transporter activity	3/1123	15/18367	0.0597614225100163	0.255081666701897	GJA1/SLC13A3/TAPBP	3
GO:0042887	amide transmembrane transporter activity	5/1123	35/18367	0.0599256306389071	0.255081666701897	SLC19A1/GJA1/SLC5A6/SLC13A3/TAPBP	5
GO:0005201	extracellular matrix structural constituent	16/1123	172/18367	0.0619835667132229	0.258252532301956	FBN1/FBN2/LAMA5/COL4A2/LAMC1/LAMB1/EFEMP1/FBLN1/COL14A1/COL4A1/LTBP1/COL21A1/FN1/COL5A2/VWA1/FRAS1	16
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	9/1123	82/18367	0.0623884019016735	0.258252532301956	PFN1/SCIN/SNX18/SLC9A1/SYT7/TTPA/ASAP1/SH3PXD2A/ANXA2	9
GO:0008028	monocarboxylic acid transmembrane transporter activity	7/1123	58/18367	0.0624516984112742	0.258252532301956	SLC27A2/SLC16A12/SLC5A6/SLC16A4/SLC16A1/SLC27A6/SLC16A2	7
GO:0019209	kinase activator activity	11/1123	107/18367	0.06247849051484	0.258252532301956	IQGAP1/CALM1/ERBB3/TAOK1/RICTOR/WNK1/BMPR2/HMGB1/BMPR1A/EFNA5/CKS1B	11
GO:0004860	protein kinase inhibitor activity	8/1123	70/18367	0.0630245642833246	0.258252532301956	NPM1/PKIB/WNK1/DNAJC3/HSPB1/TAOK3/IBTK/CDKN1C	8
GO:0005112	Notch binding	4/1123	25/18367	0.0630866373086898	0.258252532301956	GALNT11/AAK1/JAG1/ADAM17	4
GO:0005160	transforming growth factor beta receptor binding	4/1123	25/18367	0.0630866373086898	0.258252532301956	TGFBR3/TGFBR1/SMAD2/SMURF2	4
GO:0008266	poly(U) RNA binding	4/1123	25/18367	0.0630866373086898	0.258252532301956	MSI2/HNRNPH1/RBMS3/HNRNPC	4
GO:0035925	mRNA 3'-UTR AU-rich region binding	4/1123	25/18367	0.0630866373086898	0.258252532301956	ZFP36L1/RBMS3/DHX36/HNRNPD	4
GO:0005044	scavenger receptor activity	6/1123	47/18367	0.0652708720722999	0.264939151618365	LRP1/COLEC12/LGALS3BP/SCARB2/SCARA3/PRSS12	6
GO:0019829	ATPase-coupled cation transmembrane transporter activity	6/1123	47/18367	0.0652708720722999	0.264939151618365	ATP2B1/ATP2B4/ATP13A3/ATP2A2/ATP1A1/ATP7B	6
GO:0042162	telomeric DNA binding	5/1123	36/18367	0.0662441658899747	0.267760031874604	HNRNPA1/SMG1/HNRNPA2B1/NCL/HNRNPD	5
GO:0060090	molecular adaptor activity	30/1123	369/18367	0.0682715850957174	0.274800271389457	SYNE2/AKAP9/IQGAP1/COL14A1/SERINC1/CUX1/ANK3/STON1/DLG5/RB1CC1/SLC9A1/DLG1/DDB1/MPP7/AKAP13/NCSTN/FRMD4A/AMFR/SORBS1/WWC2/PKP2/CAV1/FEM1B/AP2A2/GNB4/OBSL1/ITSN2/SKP1/ABI2/MAVS	30
GO:0019842	vitamin binding	14/1123	148/18367	0.0691698723089415	0.275002439748686	GLDC/SLC19A1/P3H1/FOLR1/P3H2/LMBRD1/TTPA/SPTLC3/MTR/PLOD1/OPN3/P4HTM/TKT/FASN	14
GO:0042626	ATPase-coupled transmembrane transporter activity	11/1123	109/18367	0.0694660538196984	0.275002439748686	SLC26A2/ATP2B1/ABCA1/ATP2B4/ATP13A3/ATP2A2/LMBRD1/ATP1A1/ABCD3/ATP7B/TAPBP	11
GO:0015085	calcium ion transmembrane transporter activity	13/1123	135/18367	0.0696980349739393	0.275002439748686	ATP2B1/ITGAV/ATP2B4/P2RX4/ITPR2/MCOLN3/ATP2A2/SEC61A1/TMEM37/TRPM7/TRPV4/PKD2/ANXA2	13
GO:0000900	translation repressor activity, mRNA regulatory element binding	3/1123	16/18367	0.070322869208084	0.275002439748686	CPEB4/CELF1/PAIP2	3
GO:0005283	amino acid:sodium symporter activity	3/1123	16/18367	0.070322869208084	0.275002439748686	SLC38A2/SLC38A1/SLC1A3	3
GO:0032183	SUMO binding	3/1123	16/18367	0.070322869208084	0.275002439748686	USP25/HERC2/TDG	3
GO:0140327	flippase activity	3/1123	16/18367	0.070322869208084	0.275002439748686	ATP10D/TMEM30A/TMEM30B	3
GO:0030371	translation repressor activity	4/1123	26/18367	0.0711003655679929	0.275800611598424	IREB2/CPEB4/CELF1/PAIP2	4
GO:0099604	ligand-gated calcium channel activity	4/1123	26/18367	0.0711003655679929	0.275800611598424	P2RX4/ITPR2/MCOLN3/PKD2	4
GO:0042393	histone binding	21/1123	244/18367	0.0718013609138103	0.277401241763396	NPM1/ATRX/BRD4/TBL1X/SMARCA2/MORC4/BPTF/KMT2C/PHIP/RSF1/KDM5A/MPHOSPH8/SMARCC1/SBNO1/TBL1XR1/IPO7/KMT2A/SUZ12/PHC3/IPO9/CKS1B	21
GO:0016409	palmitoyltransferase activity	5/1123	37/18367	0.0729189826313529	0.280592245165446	SPTLC3/ZDHHC20/CPT2/ZDHHC17/ZDHHC21	5
GO:0004674	protein serine/threonine kinase activity	31/1123	386/18367	0.073387468602665	0.281269899584716	EGFR/CDK6/AAK1/BRD4/TGFBR3/PRKDC/LTBP1/CDKL5/RPS6KA5/PKN2/SMG1/TAOK1/AKAP13/ROCK1/MAP3K2/TGFBR1/PRKCI/LATS2/WNK1/BMPR2/TAOK3/AKT3/MAPK14/CSNK1A1/MAST4/CDK12/BMPR1A/CDK13/ATM/ACVR2B/NRK	31
GO:0008237	metallopeptidase activity	17/1123	190/18367	0.0742521112199106	0.283454488069659	ADAMTS6/MME/CPD/ENPEP/YME1L1/ADAM10/LNPEP/CPM/ADAMTS1/TFRC/NPEPPS/MMP15/ADAM17/ADAMTS19/NAALADL2/ERAP1/EIF3H	17
GO:0140677	molecular function activator activity	14/1123	150/18367	0.0754534876899979	0.286902194299518	PSAP/CALM1/GM2A/MMP15/BMPR2/CTSA/RAB3GAP2/CFLAR/SH3PXD2A/SUZ12/BMPR1A/TOR1AIP2/DNAJA1/PPP1R12B	14
GO:0032182	ubiquitin-like protein binding	11/1123	111/18367	0.0769361247908847	0.291388000192248	N4BP2/USP25/UBR5/UBXN7/AMFR/DDI2/HSPB1/TAB2/HERC2/TDG/CKS1B	11
GO:0005507	copper ion binding	7/1123	61/18367	0.0776602165155678	0.291832532374907	F5/P2RX4/GPC1/AOC1/CUTA/ATP7B/SOD1	7
GO:0043621	protein self-association	7/1123	61/18367	0.0776602165155678	0.291832532374907	SLC2A1/CTSC/PLEC/FOXP1/ABCD3/TMEM43/TDG	7
GO:0042562	hormone binding	9/1123	86/18367	0.0792492946628333	0.295347476745297	EGFR/LRP2/SLC40A1/IGF1R/PRLR/NR3C1/ATP1A1/EDNRB/INSR	9
GO:0016405	CoA-ligase activity	4/1123	27/18367	0.0796066656135658	0.295347476745297	SLC27A2/ACSS1/SLC27A6/ACSL3	4
GO:0022884	macromolecule transmembrane transporter activity	4/1123	27/18367	0.0796066656135658	0.295347476745297	ABCA1/SEC63/SEC61A1/HNRNPA3	4
GO:0004697	protein kinase C activity	3/1123	17/18367	0.0816564228831287	0.295347476745297	PKN2/SMG1/PRKCI	3
GO:0008308	voltage-gated anion channel activity	3/1123	17/18367	0.0816564228831287	0.295347476745297	ANO6/VDAC1/CLCN3	3
GO:0015095	magnesium ion transmembrane transporter activity	3/1123	17/18367	0.0816564228831287	0.295347476745297	TUSC3/ZDHHC17/CNNM2	3
GO:0015174	basic amino acid transmembrane transporter activity	3/1123	17/18367	0.0816564228831287	0.295347476745297	SLC38A9/SLC7A6/SLC7A2	3
GO:0015278	calcium-release channel activity	3/1123	17/18367	0.0816564228831287	0.295347476745297	ITPR2/MCOLN3/PKD2	3
GO:0042800	histone methyltransferase activity (H3-K4 specific)	3/1123	17/18367	0.0816564228831287	0.295347476745297	ASH1L/KMT2C/KMT2A	3
GO:0019210	kinase inhibitor activity	8/1123	74/18367	0.0816657264181383	0.295347476745297	NPM1/PKIB/WNK1/DNAJC3/HSPB1/TAOK3/IBTK/CDKN1C	8
GO:0015485	cholesterol binding	6/1123	50/18367	0.0830439862632811	0.299207171480436	ABCA1/SCARB2/VDAC1/NPC1/OSBPL8/CAV1	6
GO:0005496	steroid binding	10/1123	100/18367	0.0848087433203042	0.304425414455719	ABCA1/NR3C1/ESRRG/SCARB2/VDAC1/NPC1/ATP1A1/PAQR7/OSBPL8/CAV1	10
GO:0001968	fibronectin binding	4/1123	28/18367	0.0885923726593899	0.313438248663859	ITGB1/ITGAV/FBLN1/CCDC80	4
GO:0008187	poly-pyrimidine tract binding	4/1123	28/18367	0.0885923726593899	0.313438248663859	MSI2/HNRNPH1/RBMS3/HNRNPC	4
GO:0070325	lipoprotein particle receptor binding	4/1123	28/18367	0.0885923726593899	0.313438248663859	LRP1/HSP90B1/CLTC/DNAJA1	4
GO:0008276	protein methyltransferase activity	9/1123	88/18367	0.0886228728030868	0.313438248663859	ASH1L/KMT2C/DNMT3A/NSD1/PRMT9/SETD2/KMT2A/PCMTD1/SUZ12	9
GO:0015297	antiporter activity	9/1123	89/18367	0.0935454301402127	0.325472507428797	SLC26A2/SLC19A1/SLC9A1/SLC7A6/SLC35D1/SLC4A2/CLCN3/SLC22A18/SLC35E1	9
GO:0008409	5'-3' exonuclease activity	3/1123	18/18367	0.0937171357149447	0.325472507428797	PLD3/XRN1/DCP2	3
GO:0046624	sphingolipid transporter activity	3/1123	18/18367	0.0937171357149447	0.325472507428797	ATP10D/ABCA1/PLEKHA8	3
GO:0055102	lipase inhibitor activity	3/1123	18/18367	0.0937171357149447	0.325472507428797	ANXA5/ANXA1/ANXA2	3
GO:0098918	structural constituent of synapse	3/1123	18/18367	0.0937171357149447	0.325472507428797	ACTG1/DLG1/ACTB	3
GO:1901682	sulfur compound transmembrane transporter activity	6/1123	52/18367	0.0962384605604109	0.333026615320559	SLC26A2/SLC13A4/GJA1/SLC19A3/SLC5A6/SLC13A3	6
GO:0030674	protein-macromolecule adaptor activity	24/1123	296/18367	0.0967441300199149	0.3335765343339	SYNE2/IQGAP1/COL14A1/SERINC1/CUX1/ANK3/STON1/DLG5/SLC9A1/DDB1/MPP7/AKAP13/NCSTN/FRMD4A/AMFR/SORBS1/CAV1/FEM1B/AP2A2/GNB4/OBSL1/SKP1/ABI2/MAVS	24
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	4/1123	29/18367	0.0980422848884418	0.335646541148331	CDK6/CDKL5/CDK12/CDK13	4
GO:0097472	cyclin-dependent protein kinase activity	4/1123	29/18367	0.0980422848884418	0.335646541148331	CDK6/CDKL5/CDK12/CDK13	4
GO:0016859	cis-trans isomerase activity	5/1123	41/18367	0.103089226264257	0.349196604458505	NKTR/PPIA/PPIG/DEGS1/FKBP14	5
GO:0030020	extracellular matrix structural constituent conferring tensile strength	5/1123	41/18367	0.103089226264257	0.349196604458505	COL4A2/COL14A1/COL4A1/COL21A1/COL5A2	5
GO:0048487	beta-tubulin binding	5/1123	41/18367	0.103089226264257	0.349196604458505	TAOK1/EML4/LRPPRC/TRPV4/APPL1	5
GO:0005326	neurotransmitter transmembrane transporter activity	3/1123	19/18367	0.106457245478516	0.359339895264326	SLC6A4/SLC28A2/SLC29A1	3
GO:0005310	dicarboxylic acid transmembrane transporter activity	4/1123	30/18367	0.107939394550365	0.360547560963373	SLC26A2/SLC19A1/SLC1A5/SLC13A3	4
GO:0005343	organic acid:sodium symporter activity	4/1123	30/18367	0.107939394550365	0.360547560963373	SLC38A2/SLC38A1/SLC1A3/SLC13A3	4
GO:0016417	S-acyltransferase activity	4/1123	30/18367	0.107939394550365	0.360547560963373	ZDHHC20/ZDHHC17/ZDHHC21/FASN	4
GO:0043130	ubiquitin binding	9/1123	92/18367	0.10924889738285	0.36240496304242	N4BP2/USP25/UBR5/UBXN7/AMFR/DDI2/HSPB1/TAB2/CKS1B	9
GO:0051213	dioxygenase activity	9/1123	92/18367	0.10924889738285	0.36240496304242	ASPH/P3H1/TET2/P3H2/P4HB/JMJD1C/KDM5A/PLOD1/P4HTM	9
GO:0008374	O-acyltransferase activity	6/1123	54/18367	0.110479644621767	0.3652282409833	CASD1/CROT/CPT2/LPCAT3/AGPAT1/GPAT4	6
GO:0005080	protein kinase C binding	6/1123	55/18367	0.117981398348448	0.380176790722682	ITGAV/TOP2B/TRPV4/HSPB1/DSP/PKP2	6
GO:1902936	phosphatidylinositol bisphosphate binding	10/1123	107/18367	0.118814097354953	0.380176790722682	PFN1/SCIN/SNX18/SLC9A1/SYT7/SNX14/TTPA/ASAP1/SH3PXD2A/ANXA2	10
GO:0061608	nuclear import signal receptor activity	3/1123	20/18367	0.119827016856482	0.380176790722682	TNPO1/KPNB1/IPO9	3
GO:0097001	ceramide binding	3/1123	20/18367	0.119827016856482	0.380176790722682	PSAP/VDAC1/PLEKHA8	3
GO:0016504	peptidase activator activity	5/1123	43/18367	0.120160473334261	0.380176790722682	FBLN1/APP/CTSC/FN1/CAV1	5
GO:0018024	histone-lysine N-methyltransferase activity	5/1123	43/18367	0.120160473334261	0.380176790722682	ASH1L/KMT2C/NSD1/SETD2/KMT2A	5
GO:0035591	signaling adaptor activity	8/1123	81/18367	0.121294187941071	0.380176790722682	IQGAP1/DLG5/MPP7/AKAP13/SORBS1/GNB4/ABI2/MAVS	8
GO:0008641	ubiquitin-like modifier activating enzyme activity	2/1123	10/18367	0.121324609929172	0.380176790722682	UBA1/UBA6	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	2/1123	10/18367	0.121324609929172	0.380176790722682	SLC35D1/SLC35B4	2
GO:0031419	cobalamin binding	2/1123	10/18367	0.121324609929172	0.380176790722682	LMBRD1/MTR	2
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/1123	10/18367	0.121324609929172	0.380176790722682	SLC27A2/SLC27A6	2
GO:0035612	AP-2 adaptor complex binding	2/1123	10/18367	0.121324609929172	0.380176790722682	AAK1/LMBRD1	2
GO:0045294	alpha-catenin binding	2/1123	10/18367	0.121324609929172	0.380176790722682	PKP2/CTNNB1	2
GO:0051880	G-quadruplex DNA binding	2/1123	10/18367	0.121324609929172	0.380176790722682	XRN1/DHX36	2
GO:0097027	ubiquitin-protein transferase activator activity	2/1123	10/18367	0.121324609929172	0.380176790722682	UBE2L3/CDC20	2
GO:0098505	G-rich strand telomeric DNA binding	2/1123	10/18367	0.121324609929172	0.380176790722682	HNRNPA1/HNRNPA2B1	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	6/1123	56/18367	0.125729974192884	0.388913939464805	BIRC6/CAST/XIAP/SERPINB9/BIRC5/PRDX3	6
GO:0030374	nuclear receptor coactivator activity	6/1123	56/18367	0.125729974192884	0.388913939464805	NCOA3/CCAR1/ACTN4/DCAF6/MED13/NCOA2	6
GO:0042054	histone methyltransferase activity	6/1123	56/18367	0.125729974192884	0.388913939464805	ASH1L/KMT2C/NSD1/SETD2/KMT2A/SUZ12	6
GO:0051287	NAD binding	6/1123	56/18367	0.125729974192884	0.388913939464805	GAPDH/LDHA/GPD1L/UXS1/IDH1/HPGD	6
GO:0031624	ubiquitin conjugating enzyme binding	4/1123	32/18367	0.128999490025515	0.396477665829219	RNF217/SIAH2/ZMYM2/RNF19A	4
GO:0140658	ATP-dependent chromatin remodeler activity	4/1123	32/18367	0.128999490025515	0.396477665829219	ATRX/SMARCA2/CHD6/SHPRH	4
GO:0005548	phospholipid transporter activity	6/1123	57/18367	0.133719198212172	0.404691832220352	ABCA1/ANO6/TMEM30A/PLEKHA8/OSBPL8/TMEM30B	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	6/1123	57/18367	0.133719198212172	0.404691832220352	PCYOX1/P4HB/PDIA3/PDIA4/ERO1B/PRDX3	6
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	3/1123	21/18367	0.133775470526062	0.404691832220352	LPCAT3/AGPAT1/GPAT4	3
GO:0070577	lysine-acetylated histone binding	3/1123	21/18367	0.133775470526062	0.404691832220352	BRD4/PHIP/KMT2A	3
GO:0140033	acetylation-dependent protein binding	3/1123	21/18367	0.133775470526062	0.404691832220352	BRD4/PHIP/KMT2A	3
GO:1901681	sulfur compound binding	21/1123	265/18367	0.13473516600527	0.406317334473574	FBN1/LRP1/ADGRG1/NRP2/FSTL1/PTPRF/APLP2/NRP1/APP/PPIA/TGFBR3/BMP7/CCDC80/FN1/GSTP1/ADAMTS1/AOC1/ZNF207/FGFR2/NAV2/TKT	21
GO:0008047	enzyme activator activity	10/1123	110/18367	0.13540232639071	0.407053243712073	PSAP/CALM1/GM2A/MMP15/CTSA/RAB3GAP2/CFLAR/SH3PXD2A/SUZ12/PPP1R12B	10
GO:0008200	ion channel inhibitor activity	4/1123	33/18367	0.140121419919047	0.411702843872538	CALM1/RASA1/WNK1/CAV1	4
GO:0000774	adenyl-nucleotide exchange factor activity	2/1123	11/18367	0.142512522878955	0.411702843872538	PFN1/SIL1	2
GO:0005049	nuclear export signal receptor activity	2/1123	11/18367	0.142512522878955	0.411702843872538	RAN/RANBP17	2
GO:0005078	MAP-kinase scaffold activity	2/1123	11/18367	0.142512522878955	0.411702843872538	IQGAP1/AKAP13	2
GO:0005247	voltage-gated chloride channel activity	2/1123	11/18367	0.142512522878955	0.411702843872538	ANO6/CLCN3	2
GO:0008199	ferric iron binding	2/1123	11/18367	0.142512522878955	0.411702843872538	FTH1/FTL	2
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	2/1123	11/18367	0.142512522878955	0.411702843872538	DSE/GNE	2
GO:0019107	myristoyltransferase activity	2/1123	11/18367	0.142512522878955	0.411702843872538	ZDHHC20/ZDHHC17	2
GO:0035197	siRNA binding	2/1123	11/18367	0.142512522878955	0.411702843872538	DICER1/AGO2	2
GO:0035673	oligopeptide transmembrane transporter activity	2/1123	11/18367	0.142512522878955	0.411702843872538	GJA1/SLC13A3	2
GO:0043560	insulin receptor substrate binding	2/1123	11/18367	0.142512522878955	0.411702843872538	IGF1R/INSR	2
GO:1901474	azole transmembrane transporter activity	2/1123	11/18367	0.142512522878955	0.411702843872538	SLC19A3/SLC28A2	2
GO:1990226	histone methyltransferase binding	2/1123	11/18367	0.142512522878955	0.411702843872538	HSP90AB1/CTNNB1	2
GO:0099106	ion channel regulator activity	12/1123	139/18367	0.143603465969224	0.413612378031117	AKAP9/ATP2B4/PRSS8/SLC5A3/CALM1/RASA1/YWHAE/DLG1/GPD1L/WNK1/PKP2/CAV1	12
GO:0046873	metal ion transmembrane transporter activity	32/1123	430/18367	0.14483195164318	0.414585678324684	ATP2B1/SLC40A1/ITGAV/SLC13A4/SLC39A10/SLC6A4/ATP2B4/SLC38A2/SLC5A3/P2RX4/ITPR2/MCOLN3/SLC11A2/SLC5A6/SLC9A1/ATP2A2/SEC61A1/KCNN4/SLC28A2/TMEM37/TUSC3/TRPM7/SLC38A1/SLC1A3/ATP1A1/SLC13A3/TRPV4/ZDHHC17/CNNM2/PKD2/ANXA2/ATP7B	32
GO:0004602	glutathione peroxidase activity	3/1123	22/18367	0.148251011791779	0.414585678324684	GPX3/GSTP1/GPX8	3
GO:0005355	glucose transmembrane transporter activity	3/1123	22/18367	0.148251011791779	0.414585678324684	SLC2A1/SLC5A3/SLC2A8	3
GO:0005416	amino acid:cation symporter activity	3/1123	22/18367	0.148251011791779	0.414585678324684	SLC38A2/SLC38A1/SLC1A3	3
GO:0005537	mannose binding	3/1123	22/18367	0.148251011791779	0.414585678324684	LMAN1/MANBA/CLN5	3
GO:0008093	cytoskeletal anchor activity	3/1123	22/18367	0.148251011791779	0.414585678324684	ANK3/OBSL1/ABI2	3
GO:0008320	protein transmembrane transporter activity	3/1123	22/18367	0.148251011791779	0.414585678324684	ABCA1/SEC63/SEC61A1	3
GO:0015149	hexose transmembrane transporter activity	3/1123	22/18367	0.148251011791779	0.414585678324684	SLC2A1/SLC5A3/SLC2A8	3
GO:0015645	fatty acid ligase activity	3/1123	22/18367	0.148251011791779	0.414585678324684	SLC27A2/SLC27A6/ACSL3	3
GO:0070182	DNA polymerase binding	3/1123	22/18367	0.148251011791779	0.414585678324684	PTGES3/HSP90AB1/HMGB1	3
GO:0016248	channel inhibitor activity	4/1123	34/18367	0.151608843581579	0.421525166258609	CALM1/RASA1/WNK1/CAV1	4
GO:0030291	protein serine/threonine kinase inhibitor activity	4/1123	34/18367	0.151608843581579	0.421525166258609	PKIB/WNK1/HSPB1/CDKN1C	4
GO:0016209	antioxidant activity	8/1123	86/18367	0.154801427068182	0.429161305013231	PRDX1/PRDX4/GPX3/GSTP1/GPX8/CAT/PRDX3/SOD1	8
GO:0030246	carbohydrate binding	21/1123	271/18367	0.157301365612512	0.43327623612488	GALNT11/LMAN1/COLEC12/AGL/GANAB/CANX/GAA/ALDOA/OLR1/MANBA/P3H1/MAN2A1/P3H2/CLN5/GUSB/CHID1/PLOD1/MLEC/SLC2A8/P4HTM/PLA2R1	21
GO:0070063	RNA polymerase binding	7/1123	73/18367	0.157636884245019	0.43327623612488	BRD4/NCOA3/PKN2/TCERG1/AGO2/STOM/ERBB2	7
GO:0140104	molecular carrier activity	7/1123	73/18367	0.157636884245019	0.43327623612488	TNPO1/EMC1/KPNB1/EMC10/RAN/RANBP17/IPO9	7
GO:0032934	sterol binding	6/1123	60/18367	0.159061361789345	0.435945954533759	ABCA1/SCARB2/VDAC1/NPC1/OSBPL8/CAV1	6
GO:0016887	ATP hydrolysis activity	21/1123	272/18367	0.161254688840974	0.439302344791113	ATP2B1/ATP10D/ATP2B4/ATRX/ATP13A3/DDX17/ATP2A2/HSPA5/KIF5B/RHOBTB3/ATP1A1/DHX36/CHD6/ABCD3/RNF213/MOV10/ATP11B/NAV2/ATP7B/HSPA1A/MLH3	21
GO:0015299	solute:proton antiporter activity	3/1123	23/18367	0.163201969444119	0.439302344791113	SLC9A1/CLCN3/SLC22A18	3
GO:0042171	lysophosphatidic acid acyltransferase activity	3/1123	23/18367	0.163201969444119	0.439302344791113	LPCAT3/AGPAT1/GPAT4	3
GO:0050750	low-density lipoprotein particle receptor binding	3/1123	23/18367	0.163201969444119	0.439302344791113	HSP90B1/CLTC/DNAJA1	3
GO:0071617	lysophospholipid acyltransferase activity	3/1123	23/18367	0.163201969444119	0.439302344791113	LPCAT3/AGPAT1/GPAT4	3
GO:0005338	nucleotide-sugar transmembrane transporter activity	2/1123	12/18367	0.164395887863618	0.439302344791113	SLC35D1/SLC35B4	2
GO:0008429	phosphatidylethanolamine binding	2/1123	12/18367	0.164395887863618	0.439302344791113	NF1/ESYT2	2
GO:0043047	single-stranded telomeric DNA binding	2/1123	12/18367	0.164395887863618	0.439302344791113	HNRNPA1/HNRNPA2B1	2
GO:0046790	virion binding	2/1123	12/18367	0.164395887863618	0.439302344791113	PPIA/ANXA2	2
GO:0003730	mRNA 3'-UTR binding	16/1123	201/18367	0.169399301016103	0.451418635948728	RPL5/ZFP36L1/LARP4/SECISBP2L/PUM2/CPEB4/RBMS3/CELF1/DHX36/PUM1/HNRNPA2B1/HNRNPC/RC3H1/HNRNPD/FUS/YBX3	16
GO:0000217	DNA secondary structure binding	4/1123	36/18367	0.175588281784707	0.463048858368675	HMGB3/HMGB1/KMT2A/HNRNPD	4
GO:0043394	proteoglycan binding	4/1123	36/18367	0.175588281784707	0.463048858368675	LRP1/PTPRF/CTSB/FN1	4
GO:0061631	ubiquitin conjugating enzyme activity	4/1123	36/18367	0.175588281784707	0.463048858368675	BIRC6/UBE2L3/UBE2H/UBE2C	4
GO:0016247	channel regulator activity	12/1123	145/18367	0.176900922801044	0.463048858368675	AKAP9/ATP2B4/PRSS8/SLC5A3/CALM1/RASA1/YWHAE/DLG1/GPD1L/WNK1/PKP2/CAV1	12
GO:0031490	chromatin DNA binding	9/1123	103/18367	0.178230467394295	0.463048858368675	ACTN4/JMJD1C/SMARCC1/SBNO1/ZFX/SUZ12/ACTB/HNRNPC/CREBBP	9
GO:0000030	mannosyltransferase activity	3/1123	24/18367	0.178577054526797	0.463048858368675	TMTC3/ALG2/DPY19L1	3
GO:0003707	steroid hormone receptor activity	3/1123	24/18367	0.178577054526797	0.463048858368675	NR3C1/ESRRG/PAQR7	3
GO:0015145	monosaccharide transmembrane transporter activity	3/1123	24/18367	0.178577054526797	0.463048858368675	SLC2A1/SLC5A3/SLC2A8	3
GO:0016769	transferase activity, transferring nitrogenous groups	3/1123	24/18367	0.178577054526797	0.463048858368675	GAPDH/BCAT1/BCAT2	3
GO:0019789	SUMO transferase activity	3/1123	24/18367	0.178577054526797	0.463048858368675	RANBP2/ZNF451/PIAS1	3
GO:0004312	fatty acid synthase activity	2/1123	13/18367	0.186810661869949	0.472291878841635	ELOVL1/FASN	2
GO:0005542	folic acid binding	2/1123	13/18367	0.186810661869949	0.472291878841635	SLC19A1/FOLR1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/1123	13/18367	0.186810661869949	0.472291878841635	SLC26A2/SLC13A4	2
GO:0031404	chloride ion binding	2/1123	13/18367	0.186810661869949	0.472291878841635	CTSC/TDG	2
GO:0042301	phosphate ion binding	2/1123	13/18367	0.186810661869949	0.472291878841635	NCEH1/CHST14	2
GO:0051011	microtubule minus-end binding	2/1123	13/18367	0.186810661869949	0.472291878841635	MACF1/CAMSAP2	2
GO:0060590	ATPase regulator activity	2/1123	13/18367	0.186810661869949	0.472291878841635	PFN1/SIL1	2
GO:0140299	small molecule sensor activity	2/1123	13/18367	0.186810661869949	0.472291878841635	TRPV4/TMEM63A	2
GO:0005109	frizzled binding	4/1123	37/18367	0.188033045318447	0.472291878841635	RNF43/ZNRF3/RYK/DVL3	4
GO:0015035	protein-disulfide reductase activity	4/1123	37/18367	0.188033045318447	0.472291878841635	P4HB/PDIA3/PDIA4/ERO1B	4
GO:0043531	ADP binding	4/1123	37/18367	0.188033045318447	0.472291878841635	ATP1A1/MYH10/MYO7A/MYO6	4
GO:0046915	transition metal ion transmembrane transporter activity	4/1123	37/18367	0.188033045318447	0.472291878841635	SLC40A1/SLC39A10/SLC11A2/ATP7B	4
GO:0140359	ABC-type transporter activity	5/1123	50/18367	0.188955749114772	0.473373517313568	ABCA1/ATP13A3/LMBRD1/ABCD3/TAPBP	5
GO:0005262	calcium channel activity	10/1123	119/18367	0.191875558416039	0.479439707003194	ITGAV/P2RX4/ITPR2/MCOLN3/SEC61A1/TMEM37/TRPM7/TRPV4/PKD2/ANXA2	10
GO:0005227	calcium activated cation channel activity	3/1123	25/18367	0.194325747783811	0.481807653010377	ANO6/KCNN4/TMEM63A	3
GO:0034237	protein kinase A regulatory subunit binding	3/1123	25/18367	0.194325747783811	0.481807653010377	AKAP9/ARFGEF1/WASF2	3
GO:0051019	mitogen-activated protein kinase binding	3/1123	25/18367	0.194325747783811	0.481807653010377	IQGAP1/TPR/MAPK14	3
GO:0003743	translation initiation factor activity	5/1123	51/18367	0.199765239522131	0.492754257487924	EIF1/EIF3A/AGO2/EIF2S2/EIF3H	5
GO:0051018	protein kinase A binding	5/1123	51/18367	0.199765239522131	0.492754257487924	AKAP9/RPS3/ARFGEF1/AKAP13/WASF2	5
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	4/1123	38/18367	0.20074912075189	0.493914716530226	NKTR/PPIA/PPIG/FKBP14	4
GO:0016835	carbon-oxygen lyase activity	7/1123	79/18367	0.207738261304299	0.506922837582953	HACD3/RPS3/ENO1/TPI1/IREB2/ECHDC2/FASN	7
GO:0015373	anion:sodium symporter activity	2/1123	14/18367	0.209610230564621	0.506922837582953	SLC13A4/SLC6A4	2
GO:0030983	mismatched DNA binding	2/1123	14/18367	0.209610230564621	0.506922837582953	TDG/MLH3	2
GO:0032977	membrane insertase activity	2/1123	14/18367	0.209610230564621	0.506922837582953	EMC1/EMC10	2
GO:0008198	ferrous iron binding	3/1123	26/18367	0.210398623725005	0.506922837582953	FTH1/TET2/FTL	3
GO:0019706	protein-cysteine S-palmitoyltransferase activity	3/1123	26/18367	0.210398623725005	0.506922837582953	ZDHHC20/ZDHHC17/ZDHHC21	3
GO:0019707	protein-cysteine S-acyltransferase activity	3/1123	26/18367	0.210398623725005	0.506922837582953	ZDHHC20/ZDHHC17/ZDHHC21	3
GO:0042974	retinoic acid receptor binding	3/1123	26/18367	0.210398623725005	0.506922837582953	ACTN4/NSD1/FUS	3
GO:0017046	peptide hormone binding	5/1123	52/18367	0.210778726645719	0.506922837582953	SLC40A1/IGF1R/PRLR/EDNRB/INSR	5
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	4/1123	39/18367	0.213712276737273	0.511420920948399	IQGAP2/IQGAP1/ASAP1/CYTH3	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4/1123	39/18367	0.213712276737273	0.511420920948399	BIRC6/UBE2L3/UBE2H/UBE2C	4
GO:0003697	single-stranded DNA binding	10/1123	123/18367	0.219863699648732	0.522457713016479	HNRNPA1/ANXA1/YBX1/PCBP2/LRPPRC/PURB/DHX36/HNRNPA2B1/HMGB1/SUB1	10
GO:0015081	sodium ion transmembrane transporter activity	12/1123	152/18367	0.219953610989266	0.522457713016479	SLC13A4/SLC6A4/SLC38A2/SLC5A3/SLC5A6/SLC9A1/SLC28A2/SLC38A1/SLC1A3/ATP1A1/SLC13A3/PKD2	12
GO:0015103	inorganic anion transmembrane transporter activity	12/1123	152/18367	0.219953610989266	0.522457713016479	SLC26A2/SLC13A4/SLC6A4/GABRE/SLC22A11/ANO6/ANKH/SLC4A2/VDAC1/CLCN3/CLDN4/CLIC3	12
GO:0015215	nucleotide transmembrane transporter activity	3/1123	27/18367	0.226747618488935	0.525966631703989	SLC19A1/SLC25A36/SLC29A1	3
GO:0023026	MHC class II protein complex binding	3/1123	27/18367	0.226747618488935	0.525966631703989	CD74/HSP90AB1/YWHAE	3
GO:0030507	spectrin binding	3/1123	27/18367	0.226747618488935	0.525966631703989	ANK3/MYO7A/CAMSAP2	3
GO:0051119	sugar transmembrane transporter activity	3/1123	27/18367	0.226747618488935	0.525966631703989	SLC2A1/SLC5A3/SLC2A8	3
GO:0051393	alpha-actinin binding	3/1123	27/18367	0.226747618488935	0.525966631703989	DAG1/PALLD/PKD2	3
GO:0051959	dynein light intermediate chain binding	3/1123	27/18367	0.226747618488935	0.525966631703989	DYNLL1/DYNC1H1/HOOK2	3
GO:0015144	carbohydrate transmembrane transporter activity	4/1123	40/18367	0.22689828706565	0.525966631703989	SLC2A1/SLC5A3/SLC17A5/SLC2A8	4
GO:0017080	sodium channel regulator activity	4/1123	40/18367	0.22689828706565	0.525966631703989	ATP2B4/PRSS8/GPD1L/PKP2	4
GO:0043014	alpha-tubulin binding	4/1123	40/18367	0.22689828706565	0.525966631703989	TAOK1/EML4/TRPV4/SETD2	4
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	4/1123	40/18367	0.22689828706565	0.525966631703989	XIAP/SERPINB9/BIRC5/PRDX3	4
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/1123	15/18367	0.232663893342253	0.531645285974458	PDE10A/PDE7A	2
GO:0005452	inorganic anion exchanger activity	2/1123	15/18367	0.232663893342253	0.531645285974458	SLC22A11/SLC4A2	2
GO:0045125	bioactive lipid receptor activity	2/1123	15/18367	0.232663893342253	0.531645285974458	S1PR2/S1PR3	2
GO:0051371	muscle alpha-actinin binding	2/1123	15/18367	0.232663893342253	0.531645285974458	PALLD/PKD2	2
GO:0071933	Arp2/3 complex binding	2/1123	15/18367	0.232663893342253	0.531645285974458	IQGAP2/WASF2	2
GO:0098847	sequence-specific single stranded DNA binding	2/1123	15/18367	0.232663893342253	0.531645285974458	HNRNPA1/HNRNPA2B1	2
GO:0005544	calcium-dependent phospholipid binding	5/1123	54/18367	0.233359444261041	0.531971055400761	ANXA5/ANXA1/SYT7/ANXA2/ESYT2	5
GO:0008094	ATP-dependent activity, acting on DNA	9/1123	111/18367	0.238132160091798	0.541567702147304	ANXA1/ATRX/SMARCA2/BPTF/TOP2B/DHX36/CHD6/SHPRH/NAV2	9
GO:0030331	estrogen receptor binding	4/1123	41/18367	0.24028305039553	0.545170505850236	NSD1/ISL1/CTNNB1/FUS	4
GO:0015036	disulfide oxidoreductase activity	4/1123	42/18367	0.253842698935292	0.561947398233464	P4HB/PDIA3/PDIA4/ERO1B	4
GO:0019894	kinesin binding	4/1123	42/18367	0.253842698935292	0.561947398233464	KTN1/CLSTN1/TRAK2/ACTB	4
GO:0004698	calcium-dependent protein kinase C activity	2/1123	16/18367	0.255855468218562	0.561947398233464	PKN2/PRKCI	2
GO:0005092	GDP-dissociation inhibitor activity	2/1123	16/18367	0.255855468218562	0.561947398233464	CHML/RANBP1	2
GO:0005159	insulin-like growth factor receptor binding	2/1123	16/18367	0.255855468218562	0.561947398233464	INSL4/INSR	2
GO:0005402	carbohydrate:cation symporter activity	2/1123	16/18367	0.255855468218562	0.561947398233464	SLC5A3/SLC17A5	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/1123	16/18367	0.255855468218562	0.561947398233464	SLC1A5/SLC1A3	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/1123	16/18367	0.255855468218562	0.561947398233464	SLC1A5/SLC13A3	2
GO:0017070	U6 snRNA binding	2/1123	16/18367	0.255855468218562	0.561947398233464	EIF5A/LSM3	2
GO:0035497	cAMP response element binding	2/1123	16/18367	0.255855468218562	0.561947398233464	ATF6/CREB3L2	2
GO:0036122	BMP binding	2/1123	16/18367	0.255855468218562	0.561947398233464	BMPR2/BMPR1A	2
GO:0042577	lipid phosphatase activity	2/1123	16/18367	0.255855468218562	0.561947398233464	PLPP3/SGPP1	2
GO:0070403	NAD+ binding	2/1123	16/18367	0.255855468218562	0.561947398233464	UXS1/HPGD	2
GO:1990404	protein ADP-ribosylase activity	2/1123	16/18367	0.255855468218562	0.561947398233464	TNKS2/PARP14	2
GO:0015301	anion:anion antiporter activity	3/1123	29/18367	0.260089782192331	0.562261506671961	SLC26A2/SLC19A1/SLC4A2	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	3/1123	29/18367	0.260089782192331	0.562261506671961	DHCR24/TECR/FASN	3
GO:0032452	histone demethylase activity	3/1123	29/18367	0.260089782192331	0.562261506671961	JMJD1C/KDM5A/JARID2	3
GO:0046625	sphingolipid binding	3/1123	29/18367	0.260089782192331	0.562261506671961	PSAP/VDAC1/PLEKHA8	3
GO:0051787	misfolded protein binding	3/1123	29/18367	0.260089782192331	0.562261506671961	HSPA5/DNAJC3/HSPA1A	3
GO:0070273	phosphatidylinositol-4-phosphate binding	3/1123	29/18367	0.260089782192331	0.562261506671961	PLEKHA8/OSBPL8/SH3PXD2A	3
GO:0140457	protein demethylase activity	3/1123	29/18367	0.260089782192331	0.562261506671961	JMJD1C/KDM5A/JARID2	3
GO:0031072	heat shock protein binding	10/1123	129/18367	0.264585634140053	0.570698161530787	RPS3/PTGES3/NR3C1/TPR/DNAJB14/HSP90AB1/HSPA5/KPNB1/DNAJA1/HSPA1A	10
GO:0005217	intracellular ligand-gated ion channel activity	3/1123	30/18367	0.276995380819216	0.588765112517431	ITPR2/MCOLN3/PKD2	3
GO:0022829	wide pore channel activity	3/1123	30/18367	0.276995380819216	0.588765112517431	GJA1/VDAC1/GJA5	3
GO:0000400	four-way junction DNA binding	2/1123	17/18367	0.27908200759662	0.588765112517431	HMGB3/HMGB1	2
GO:0008484	sulfuric ester hydrolase activity	2/1123	17/18367	0.27908200759662	0.588765112517431	STS/GNS	2
GO:0015116	sulfate transmembrane transporter activity	2/1123	17/18367	0.27908200759662	0.588765112517431	SLC26A2/SLC13A4	2
GO:0016854	racemase and epimerase activity	2/1123	17/18367	0.27908200759662	0.588765112517431	DSE/GNE	2
GO:0031420	alkali metal ion binding	2/1123	17/18367	0.27908200759662	0.588765112517431	ATP1A1/TDG	2
GO:0031489	myosin V binding	2/1123	17/18367	0.27908200759662	0.588765112517431	RAB6A/FUS	2
GO:0043024	ribosomal small subunit binding	2/1123	17/18367	0.27908200759662	0.588765112517431	NPM1/EIF1	2
GO:0046965	retinoid X receptor binding	2/1123	17/18367	0.27908200759662	0.588765112517431	NSD1/FUS	2
GO:0051879	Hsp90 protein binding	4/1123	44/18367	0.281392925877337	0.592341345063454	RPS3/PTGES3/NR3C1/KPNB1	4
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	16/1123	222/18367	0.283922610551307	0.596361465830475	NCOA3/CASD1/HGSNAT/CROT/SPTLC3/ZDHHC20/SAT1/CPT2/ZDHHC17/ZDHHC21/LPCAT3/AGPAT1/CREBBP/ELOVL1/FASN/GPAT4	16
GO:0004725	protein tyrosine phosphatase activity	8/1123	102/18367	0.285301288192097	0.597951719478862	PTPRF/PTPN14/PTPRA/PTP4A1/PTPRM/DNAJC6/PTPRK/CDKN3	8
GO:0035064	methylated histone binding	6/1123	73/18367	0.287632134435356	0.600221503962717	ATRX/MORC4/BPTF/KDM5A/MPHOSPH8/SUZ12	6
GO:0140034	methylation-dependent protein binding	6/1123	73/18367	0.287632134435356	0.600221503962717	ATRX/MORC4/BPTF/KDM5A/MPHOSPH8/SUZ12	6
GO:0016279	protein-lysine N-methyltransferase activity	5/1123	59/18367	0.292353916934875	0.606931570341906	ASH1L/KMT2C/NSD1/SETD2/KMT2A	5
GO:0016411	acylglycerol O-acyltransferase activity	3/1123	31/18367	0.294002195196807	0.606931570341906	LPCAT3/AGPAT1/GPAT4	3
GO:0042910	xenobiotic transmembrane transporter activity	3/1123	31/18367	0.294002195196807	0.606931570341906	SLC2A1/SLC19A1/SLC22A5	3
GO:0071813	lipoprotein particle binding	3/1123	31/18367	0.294002195196807	0.606931570341906	COLEC12/ABCA1/VLDLR	3
GO:0071814	protein-lipid complex binding	3/1123	31/18367	0.294002195196807	0.606931570341906	COLEC12/ABCA1/VLDLR	3
GO:0043178	alcohol binding	7/1123	89/18367	0.301729623454087	0.617339739175627	ABCA1/ITPR2/SCARB2/VDAC1/NPC1/OSBPL8/CAV1	7
GO:0000295	adenine nucleotide transmembrane transporter activity	2/1123	18/18367	0.30225261658183	0.617339739175627	SLC19A1/SLC29A1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/1123	18/18367	0.30225261658183	0.617339739175627	SLC19A1/SLC29A1	2
GO:0008301	DNA binding, bending	2/1123	18/18367	0.30225261658183	0.617339739175627	HMGB3/HMGB1	2
GO:0140597	protein carrier activity	2/1123	18/18367	0.30225261658183	0.617339739175627	EMC1/EMC10	2
GO:0016278	lysine N-methyltransferase activity	5/1123	60/18367	0.304471421948105	0.620554042190842	ASH1L/KMT2C/NSD1/SETD2/KMT2A	5
GO:0015605	organophosphate ester transmembrane transporter activity	3/1123	32/18367	0.311071440559354	0.630001528038101	SLC19A1/SLC25A36/SLC29A1	3
GO:0030332	cyclin binding	3/1123	32/18367	0.311071440559354	0.630001528038101	CDK6/CDK12/CDK13	3
GO:0071889	14-3-3 protein binding	3/1123	32/18367	0.311071440559354	0.630001528038101	ZFP36L1/TMCC3/PPP1R12A	3
GO:0043177	organic acid binding	10/1123	135/18367	0.311892141768355	0.630336639456212	GLDC/SLC19A1/P3H1/FOLR1/P3H2/SLC1A3/NR2F2/PLOD1/GCHFR/P4HTM	10
GO:0016829	lyase activity	14/1123	196/18367	0.312668387283799	0.630580688819736	HACD3/GLDC/ALDOA/RPS3/ENO1/TPI1/IREB2/ADCY7/ECHDC2/UXS1/APMAP/HMGB1/PISD/FASN	14
GO:0015399	primary active transmembrane transporter activity	13/1123	181/18367	0.314741851938418	0.633434438419996	SLC26A2/ATP2B1/ABCA1/ATP2B4/ATP13A3/COX6A1/ATP2A2/LMBRD1/ATP1A1/ABCD3/ATP7B/TAPBP/UQCRH	13
GO:0035254	glutamate receptor binding	4/1123	47/18367	0.323456694323493	0.649614488390816	CANX/CALM1/MYL12A/FUS	4
GO:0035613	RNA stem-loop binding	2/1123	19/18367	0.325287366123396	0.650574732246791	MYH10/RC3H1	2
GO:0035615	clathrin adaptor activity	2/1123	19/18367	0.325287366123396	0.650574732246791	STON1/AP2A2	2
GO:0140097	catalytic activity, acting on DNA	16/1123	229/18367	0.326919096278175	0.650919830523085	ANXA1/DICER1/ATRX/PLD3/SMARCA2/RPS3/PTGES3/BPTF/DNMT3A/TOP2B/REV3L/DHX36/CHD6/SHPRH/NAV2/TDG	16
GO:0005154	epidermal growth factor receptor binding	3/1123	33/18367	0.328166442623385	0.650919830523085	EFEMP1/VAV3/ARF4	3
GO:0019956	chemokine binding	3/1123	33/18367	0.328166442623385	0.650919830523085	ITGB1/ITGAV/HMGB1	3
GO:0140323	solute:anion antiporter activity	3/1123	33/18367	0.328166442623385	0.650919830523085	SLC26A2/SLC19A1/SLC4A2	3
GO:0120013	lipid transfer activity	4/1123	48/18367	0.337588597990777	0.668230928533183	ABCA1/TTPA/PLEKHA8/OSBPL8	4
GO:0001221	transcription coregulator binding	6/1123	78/18367	0.342132664479009	0.675834955295292	RPL23/CHD6/SUZ12/ZNF644/CREBBP/CTNNB1	6
GO:0008376	acetylgalactosaminyltransferase activity	3/1123	34/18367	0.345252661885495	0.677910677438402	GALNT11/CHPF/EXTL2	3
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/1123	20/18367	0.34811629381972	0.677910677438402	GLDC/AOC1	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/1123	20/18367	0.34811629381972	0.677910677438402	CDS1/GNPTAB	2
GO:0030296	protein tyrosine kinase activator activity	2/1123	20/18367	0.34811629381972	0.677910677438402	ERBB3/EFNA5	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/1123	20/18367	0.34811629381972	0.677910677438402	GNAQ/GNA12	2
GO:0031690	adrenergic receptor binding	2/1123	20/18367	0.34811629381972	0.677910677438402	ADRB1/RAPGEF2	2
GO:0140312	cargo adaptor activity	2/1123	20/18367	0.34811629381972	0.677910677438402	STON1/AP2A2	2
GO:0016836	hydro-lyase activity	5/1123	64/18367	0.353530016463594	0.687062375430257	HACD3/ENO1/IREB2/ECHDC2/FASN	5
GO:0019783	ubiquitin-like protein-specific protease activity	9/1123	125/18367	0.355887715094084	0.690249963549413	USP25/USP47/USP9X/USP34/SENP6/USP12/USP10/EIF3H/USP43	9
GO:0004386	helicase activity	11/1123	156/18367	0.357233418866013	0.691465893257756	ANXA1/DICER1/ATRX/SMARCA2/DDX17/HELZ/DHX36/CHD6/MOV10/SHPRH/NAV2	11
GO:0016746	acyltransferase activity	17/1123	250/18367	0.360731790337935	0.696835305833522	NCOA3/KMT2C/CASD1/HGSNAT/CROT/SPTLC3/ZDHHC20/SAT1/CPT2/ZDHHC17/ZDHHC21/LPCAT3/AGPAT1/CREBBP/ELOVL1/FASN/GPAT4	17
GO:0015298	solute:cation antiporter activity	3/1123	35/18367	0.362297698727181	0.698457687726549	SLC9A1/CLCN3/SLC22A18	3
GO:0005048	signal sequence binding	4/1123	50/18367	0.365897157328898	0.703986130700801	TNPO1/SEC61A1/KPNB1/CAT	4
GO:0004222	metalloendopeptidase activity	8/1123	111/18367	0.368358806092343	0.704728662622617	ADAMTS6/MME/YME1L1/ADAM10/ADAMTS1/MMP15/ADAM17/ADAMTS19	8
GO:0005123	death receptor binding	2/1123	21/18367	0.370678485745368	0.704728662622617	CFLAR/FEM1B	2
GO:0005243	gap junction channel activity	2/1123	21/18367	0.370678485745368	0.704728662622617	GJA1/GJA5	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/1123	21/18367	0.370678485745368	0.704728662622617	SLC19A1/SLC29A1	2
GO:0051010	microtubule plus-end binding	2/1123	21/18367	0.370678485745368	0.704728662622617	CLIP1/DST	2
GO:1990381	ubiquitin-specific protease binding	2/1123	21/18367	0.370678485745368	0.704728662622617	CLTC/AMFR	2
GO:0004721	phosphoprotein phosphatase activity	12/1123	174/18367	0.376033309563826	0.713499100198028	PTPRF/DLG1/PTPN14/PTPRA/PDP2/PTP4A1/PTPRM/PPP4R1/DNAJC6/PTPRK/PPP3CA/CDKN3	12
GO:0015248	sterol transporter activity	3/1123	36/18367	0.379271282085588	0.715409751698697	ABCA1/NPC1/OSBPL8	3
GO:0023023	MHC protein complex binding	3/1123	36/18367	0.379271282085588	0.715409751698697	CD74/HSP90AB1/YWHAE	3
GO:0042805	actinin binding	3/1123	36/18367	0.379271282085588	0.715409751698697	DAG1/PALLD/PKD2	3
GO:0008170	N-methyltransferase activity	7/1123	97/18367	0.38211597374713	0.719365101261721	ASH1L/KMT2C/NSD1/PRMT9/RNMT/SETD2/KMT2A	7
GO:0140030	modification-dependent protein binding	11/1123	160/18367	0.388734124057199	0.730394975279347	AGL/ATRX/BRD4/MORC4/BPTF/PHIP/KDM5A/MPHOSPH8/KMT2A/SUZ12/TAB2	11
GO:0031406	carboxylic acid binding	12/1123	176/18367	0.391100538117189	0.732325417683728	PSAP/GLDC/SLC19A1/P3H1/FOLR1/P3H2/GSTP1/SLC1A3/NR2F2/PLOD1/ACOX1/P4HTM	12
GO:0015296	anion:cation symporter activity	2/1123	22/18367	0.392921233140727	0.732325417683728	SLC13A4/SLC6A4	2
GO:0030742	GTP-dependent protein binding	2/1123	22/18367	0.392921233140727	0.732325417683728	EEA1/GCHFR	2
GO:0050321	tau-protein kinase activity	2/1123	22/18367	0.392921233140727	0.732325417683728	TAOK1/ROCK1	2
GO:0008146	sulfotransferase activity	4/1123	52/18367	0.394140820392837	0.732325417683728	HS6ST2/TPST2/CHST11/CHST14	4
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3/1123	37/18367	0.396145244153276	0.732325417683728	GAPDH/ALDH18A1/ALDH4A1	3
GO:0030551	cyclic nucleotide binding	3/1123	37/18367	0.396145244153276	0.732325417683728	SLC19A1/PDE10A/RAPGEF2	3
GO:0071949	FAD binding	3/1123	37/18367	0.396145244153276	0.732325417683728	DHCR24/ERO1B/ACOX1	3
GO:0101005	deubiquitinase activity	8/1123	114/18367	0.396612830159275	0.732325417683728	USP25/USP47/USP9X/USP34/USP12/USP10/EIF3H/USP43	8
GO:0015078	proton transmembrane transporter activity	9/1123	130/18367	0.399928361049689	0.737032726685442	COX6A1/SLC17A5/ATP6V1B1/SLC11A2/SLC9A1/CLCN3/SLC22A18/ATP6V0A1/UQCRH	9
GO:0003684	damaged DNA binding	5/1123	68/18367	0.402893812827873	0.739663831947354	RPS3/DDB1/HMGB1/TDG/CREBBP	5
GO:0016782	transferase activity, transferring sulphur-containing groups	5/1123	68/18367	0.402893812827873	0.739663831947354	HS6ST2/TPST2/CHST11/CHST14/TSTD1	5
GO:0001540	amyloid-beta binding	6/1123	84/18367	0.408616940582634	0.748662075874318	LRP1/CD74/ITM2B/FZD5/CLSTN1/INSR	6
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	3/1123	38/18367	0.412893483301967	0.748662075874318	CNOT6L/XRN1/DCP2	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/1123	23/18367	0.414799258254689	0.748662075874318	TNKS2/PARP14	2
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/1123	23/18367	0.414799258254689	0.748662075874318	PDE10A/PDE7A	2
GO:0008143	poly(A) binding	2/1123	23/18367	0.414799258254689	0.748662075874318	LARP4/RBMS3	2
GO:0008483	transaminase activity	2/1123	23/18367	0.414799258254689	0.748662075874318	BCAT1/BCAT2	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/1123	23/18367	0.414799258254689	0.748662075874318	PKN2/PRKCI	2
GO:0030552	cAMP binding	2/1123	23/18367	0.414799258254689	0.748662075874318	PDE10A/RAPGEF2	2
GO:0070412	R-SMAD binding	2/1123	23/18367	0.414799258254689	0.748662075874318	TRIM33/SMAD2	2
GO:0032451	demethylase activity	3/1123	39/18367	0.429491917182358	0.773728884512038	JMJD1C/KDM5A/JARID2	3
GO:0010857	calcium-dependent protein kinase activity	2/1123	24/18367	0.436274004048134	0.781556037047123	PKN2/PRKCI	2
GO:0015295	solute:proton symporter activity	2/1123	24/18367	0.436274004048134	0.781556037047123	SLC17A5/SLC11A2	2
GO:0043274	phospholipase binding	2/1123	24/18367	0.436274004048134	0.781556037047123	SRSF3/PLA2R1	2
GO:0015631	tubulin binding	24/1123	375/18367	0.438573303747782	0.782949649858232	GAPDH/DAG1/CLIP1/MACF1/DST/ALDOA/GJA1/RPS3/CEP350/TPR/TAOK1/EML4/GPAA1/KIF5B/LRPPRC/HOOK2/TRPV4/SETD2/CAMSAP2/ZNF207/APPL1/NUSAP1/BIRC5/CAPN6	24
GO:0005253	anion channel activity	6/1123	87/18367	0.441728735405024	0.782949649858232	GABRE/ANO6/VDAC1/CLCN3/CLDN4/CLIC3	6
GO:0106310	protein serine kinase activity	23/1123	360/18367	0.444531566109653	0.782949649858232	CDK6/AAK1/PRKDC/CDKL5/RPS6KA5/PKN2/SMG1/TAOK1/ROCK1/MAP3K2/TRPM7/PRKCI/LATS2/WNK1/TAOK3/AKT3/MAPK14/CSNK1A1/MAST4/CDK12/CDK13/ATM/NRK	23
GO:0004532	exoribonuclease activity	3/1123	40/18367	0.445918427732361	0.782949649858232	CNOT6L/XRN1/DCP2	3
GO:0031492	nucleosomal DNA binding	3/1123	40/18367	0.445918427732361	0.782949649858232	SMARCC1/ACTB/HNRNPC	3
GO:0042169	SH2 domain binding	3/1123	40/18367	0.445918427732361	0.782949649858232	DAG1/ARHGAP5/TRPV4	3
GO:0003678	DNA helicase activity	5/1123	72/18367	0.451789882801036	0.782949649858232	ANXA1/ATRX/DHX36/CHD6/NAV2	5
GO:0004112	cyclic-nucleotide phosphodiesterase activity	2/1123	25/18367	0.457312982853728	0.782949649858232	PDE10A/PDE7A	2
GO:0008327	methyl-CpG binding	2/1123	25/18367	0.457312982853728	0.782949649858232	ZBTB38/ERH	2
GO:0043175	RNA polymerase core enzyme binding	4/1123	57/18367	0.463592359361115	0.782949649858232	BRD4/NCOA3/AGO2/ERBB2	4
GO:0004300	enoyl-CoA hydratase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	ECHDC2	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	AKAP13	1
GO:0004955	prostaglandin receptor activity	1/1123	10/18367	0.467979260570149	0.782949649858232	HPGD	1
GO:0005384	manganese ion transmembrane transporter activity	1/1123	10/18367	0.467979260570149	0.782949649858232	SLC11A2	1
GO:0005522	profilin binding	1/1123	10/18367	0.467979260570149	0.782949649858232	ACTG1	1
GO:0008097	5S rRNA binding	1/1123	10/18367	0.467979260570149	0.782949649858232	RPL5	1
GO:0015643	toxic substance binding	1/1123	10/18367	0.467979260570149	0.782949649858232	TMEM181	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/1123	10/18367	0.467979260570149	0.782949649858232	SH3PXD2A	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	ATM	1
GO:0016595	glutamate binding	1/1123	10/18367	0.467979260570149	0.782949649858232	SLC1A3	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1/1123	10/18367	0.467979260570149	0.782949649858232	ACOX1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/1123	10/18367	0.467979260570149	0.782949649858232	DEGS1	1
GO:0016783	sulfurtransferase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	TSTD1	1
GO:0019203	carbohydrate phosphatase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	G6PC3	1
GO:0019531	oxalate transmembrane transporter activity	1/1123	10/18367	0.467979260570149	0.782949649858232	SLC26A2	1
GO:0019869	chloride channel inhibitor activity	1/1123	10/18367	0.467979260570149	0.782949649858232	WNK1	1
GO:0032356	oxidized DNA binding	1/1123	10/18367	0.467979260570149	0.782949649858232	RPS3	1
GO:0034511	U3 snoRNA binding	1/1123	10/18367	0.467979260570149	0.782949649858232	PRKDC	1
GO:0034713	type I transforming growth factor beta receptor binding	1/1123	10/18367	0.467979260570149	0.782949649858232	SMAD2	1
GO:0043208	glycosphingolipid binding	1/1123	10/18367	0.467979260570149	0.782949649858232	PSAP	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/1123	10/18367	0.467979260570149	0.782949649858232	ASH1L	1
GO:0050308	sugar-phosphatase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	G6PC3	1
GO:0050786	RAGE receptor binding	1/1123	10/18367	0.467979260570149	0.782949649858232	HMGB1	1
GO:0070016	armadillo repeat domain binding	1/1123	10/18367	0.467979260570149	0.782949649858232	TCF7L2	1
GO:0070567	cytidylyltransferase activity	1/1123	10/18367	0.467979260570149	0.782949649858232	CDS1	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/1123	10/18367	0.467979260570149	0.782949649858232	CFLAR	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/1123	10/18367	0.467979260570149	0.782949649858232	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/1123	10/18367	0.467979260570149	0.782949649858232	PLEKHA8	1
GO:0005254	chloride channel activity	5/1123	74/18367	0.475850041025312	0.78806210938523	GABRE/ANO6/CLCN3/CLDN4/CLIC3	5
GO:0097602	cullin family protein binding	2/1123	26/18367	0.477889179447788	0.78806210938523	DDB1/SKP1	2
GO:0019205	nucleobase-containing compound kinase activity	3/1123	42/18367	0.478176653526765	0.78806210938523	N4BP2/DLG1/AK3	3
GO:0016407	acetyltransferase activity	6/1123	91/18367	0.485252275902079	0.78806210938523	NCOA3/CASD1/HGSNAT/SAT1/CREBBP/FASN	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	10/1123	156/18367	0.485602000131352	0.78806210938523	ASH1L/KMT2C/DNMT3A/NSD1/PRMT9/RNMT/SETD2/KMT2A/PCMTD1/TARBP1	10
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	4/1123	59/18367	0.490608860439983	0.78806210938523	PLD3/CNOT6L/XRN1/DCP2	4
GO:0036002	pre-mRNA binding	4/1123	59/18367	0.490608860439983	0.78806210938523	HNRNPA1/SF1/CELF1/TRA2B	4
GO:0004180	carboxypeptidase activity	3/1123	43/18367	0.49397337530881	0.78806210938523	CPD/CPM/CTSA	3
GO:0016790	thiolester hydrolase activity	3/1123	43/18367	0.49397337530881	0.78806210938523	LYPLA1/ABCD3/FASN	3
GO:0030544	Hsp70 protein binding	3/1123	43/18367	0.49397337530881	0.78806210938523	RPS3/DNAJB14/DNAJA1	3
GO:0070851	growth factor receptor binding	9/1123	141/18367	0.496452499770814	0.78806210938523	IL6ST/EFEMP1/APP/NCSTN/ADAM17/VAV3/PDGFD/ERAP1/ARF4	9
GO:0001671	ATPase activator activity	2/1123	27/18367	0.497980504324496	0.78806210938523	TOR1AIP2/DNAJA1	2
GO:0004709	MAP kinase kinase kinase activity	2/1123	27/18367	0.497980504324496	0.78806210938523	EGFR/MAP3K2	2
GO:0008139	nuclear localization sequence binding	2/1123	27/18367	0.497980504324496	0.78806210938523	TNPO1/KPNB1	2
GO:0035255	ionotropic glutamate receptor binding	2/1123	27/18367	0.497980504324496	0.78806210938523	CANX/FUS	2
GO:0043425	bHLH transcription factor binding	2/1123	27/18367	0.497980504324496	0.78806210938523	ISL1/CREBBP	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/1123	11/18367	0.500525934339268	0.78806210938523	NCOA2	1
GO:0004016	adenylate cyclase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	ADCY7	1
GO:0004954	prostanoid receptor activity	1/1123	11/18367	0.500525934339268	0.78806210938523	HPGD	1
GO:0005536	glucose binding	1/1123	11/18367	0.500525934339268	0.78806210938523	SLC2A8	1
GO:0008503	benzodiazepine receptor activity	1/1123	11/18367	0.500525934339268	0.78806210938523	GABRE	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/1123	11/18367	0.500525934339268	0.78806210938523	PKIB	1
GO:0015378	sodium:chloride symporter activity	1/1123	11/18367	0.500525934339268	0.78806210938523	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/1123	11/18367	0.500525934339268	0.78806210938523	SLC9A1	1
GO:0016273	arginine N-methyltransferase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	PRMT9	1
GO:0016274	protein-arginine N-methyltransferase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	PRMT9	1
GO:0016832	aldehyde-lyase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	ALDOA	1
GO:0017128	phospholipid scramblase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	ANO6	1
GO:0019855	calcium channel inhibitor activity	1/1123	11/18367	0.500525934339268	0.78806210938523	CALM1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/1123	11/18367	0.500525934339268	0.78806210938523	DLG1	1
GO:0035252	UDP-xylosyltransferase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	GXYLT1	1
GO:0042285	xylosyltransferase activity	1/1123	11/18367	0.500525934339268	0.78806210938523	GXYLT1	1
GO:0042608	T cell receptor binding	1/1123	11/18367	0.500525934339268	0.78806210938523	MR1	1
GO:0048407	platelet-derived growth factor binding	1/1123	11/18367	0.500525934339268	0.78806210938523	COL4A1	1
GO:0097371	MDM2/MDM4 family protein binding	1/1123	11/18367	0.500525934339268	0.78806210938523	RPS20	1
GO:1901612	cardiolipin binding	1/1123	11/18367	0.500525934339268	0.78806210938523	MME	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	4/1123	60/18367	0.503904391760831	0.792085007963921	DHCR24/TECR/ACOX1/FASN	4
GO:0008242	omega peptidase activity	8/1123	126/18367	0.508538917157979	0.7957239882004	USP25/USP47/USP9X/USP34/USP12/GGH/USP10/USP43	8
GO:0009055	electron transfer activity	8/1123	126/18367	0.508538917157979	0.7957239882004	GLDC/ASPH/COX6A1/DEGS1/ALDH4A1/DHRS3/CYCS/UQCRH	8
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3/1123	44/18367	0.509528042340381	0.7957239882004	GAPDH/ALDH18A1/ALDH4A1	3
GO:0022839	ion gated channel activity	3/1123	44/18367	0.509528042340381	0.7957239882004	ANO6/KCNN4/TMEM63A	3
GO:0050681	androgen receptor binding	2/1123	28/18367	0.51756929327342	0.803305108903332	NSD1/FOXP1	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/1123	28/18367	0.51756929327342	0.803305108903332	FEM1B/SKP1	2
GO:1990841	promoter-specific chromatin binding	4/1123	62/18367	0.53001897872608	0.803305108903332	NIPBL/ZNF609/ISL1/FOXO4	4
GO:0000340	RNA 7-methylguanosine cap binding	1/1123	12/18367	0.5310832112916	0.803305108903332	AGO2	1
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/1123	12/18367	0.5310832112916	0.803305108903332	RPS3	1
GO:0003964	RNA-directed DNA polymerase activity	1/1123	12/18367	0.5310832112916	0.803305108903332	PTGES3	1
GO:0003995	acyl-CoA dehydrogenase activity	1/1123	12/18367	0.5310832112916	0.803305108903332	TECR	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/1123	12/18367	0.5310832112916	0.803305108903332	CDKN1C	1
GO:0005165	neurotrophin receptor binding	1/1123	12/18367	0.5310832112916	0.803305108903332	EFNA5	1
GO:0008174	mRNA methyltransferase activity	1/1123	12/18367	0.5310832112916	0.803305108903332	RNMT	1
GO:0015166	polyol transmembrane transporter activity	1/1123	12/18367	0.5310832112916	0.803305108903332	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/1123	12/18367	0.5310832112916	0.803305108903332	KCNN4	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/1123	12/18367	0.5310832112916	0.803305108903332	SLC22A5	1
GO:0030955	potassium ion binding	1/1123	12/18367	0.5310832112916	0.803305108903332	ATP1A1	1
GO:0033130	acetylcholine receptor binding	1/1123	12/18367	0.5310832112916	0.803305108903332	LY6E	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/1123	12/18367	0.5310832112916	0.803305108903332	ATM	1
GO:0035256	G protein-coupled glutamate receptor binding	1/1123	12/18367	0.5310832112916	0.803305108903332	CALM1	1
GO:0043176	amine binding	1/1123	12/18367	0.5310832112916	0.803305108903332	SLC6A4	1
GO:0043422	protein kinase B binding	1/1123	12/18367	0.5310832112916	0.803305108903332	APPL1	1
GO:0051378	serotonin binding	1/1123	12/18367	0.5310832112916	0.803305108903332	SLC6A4	1
GO:0017171	serine hydrolase activity	12/1123	195/18367	0.533448387651392	0.80561593237149	CPD/CTSC/DPP4/PRSS8/FURIN/ST14/TPP1/PCSK7/NCEH1/CTSA/PRSS12/DPP7	12
GO:0004181	metallocarboxypeptidase activity	2/1123	29/18367	0.536641849649797	0.806139568824084	CPD/CPM	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/1123	29/18367	0.536641849649797	0.806139568824084	TTPA/SH3PXD2A	2
GO:0070717	poly-purine tract binding	2/1123	29/18367	0.536641849649797	0.806139568824084	LARP4/RBMS3	2
GO:0004864	protein phosphatase inhibitor activity	3/1123	46/18367	0.539859523125229	0.806139568824084	PHACTR2/BOD1L1/PPP1R14B	3
GO:0004843	thiol-dependent deubiquitinase	7/1123	113/18367	0.541403537427061	0.806139568824084	USP25/USP47/USP9X/USP34/USP12/USP10/USP43	7
GO:0017124	SH3 domain binding	8/1123	130/18367	0.544502626523855	0.806139568824084	LRP2/GJA1/ADAM10/SH3BGRL2/ADAM17/DNAJC6/ABI2/WASF2	8
GO:0004896	cytokine receptor activity	6/1123	97/18367	0.548313234952368	0.806139568824084	CSF3R/IL6ST/PRLR/CD74/LIFR/IL10RB	6
GO:0008168	methyltransferase activity	13/1123	214/18367	0.550579553692234	0.806139568824084	ASH1L/METTL7A/KMT2C/DNMT3A/NSD1/PRMT9/MTR/RNMT/SETD2/KMT2A/PCMTD1/SUZ12/TARBP1	13
GO:0003774	cytoskeletal motor activity	7/1123	114/18367	0.550875826687571	0.806139568824084	MYO1C/DYNC1H1/KIF5B/MYH10/MYO7A/MYO6/MYL6	7
GO:0002161	aminoacyl-tRNA editing activity	1/1123	13/18367	0.559772590410071	0.806139568824084	IARS2	1
GO:0004535	poly(A)-specific ribonuclease activity	1/1123	13/18367	0.559772590410071	0.806139568824084	CNOT6L	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/1123	13/18367	0.559772590410071	0.806139568824084	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/1123	13/18367	0.559772590410071	0.806139568824084	ABCA1	1
GO:0008179	adenylate cyclase binding	1/1123	13/18367	0.559772590410071	0.806139568824084	CALM1	1
GO:0008195	phosphatidate phosphatase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	PLPP3	1
GO:0015271	outward rectifier potassium channel activity	1/1123	13/18367	0.559772590410071	0.806139568824084	PKD2	1
GO:0015385	sodium:proton antiporter activity	1/1123	13/18367	0.559772590410071	0.806139568824084	SLC9A1	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	TARBP1	1
GO:0016594	glycine binding	1/1123	13/18367	0.559772590410071	0.806139568824084	GLDC	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/1123	13/18367	0.559772590410071	0.806139568824084	PRDX3	1
GO:0016840	carbon-nitrogen lyase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	APMAP	1
GO:0019104	DNA N-glycosylase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	TDG	1
GO:0022851	GABA-gated chloride ion channel activity	1/1123	13/18367	0.559772590410071	0.806139568824084	GABRE	1
GO:0031386	protein tag	1/1123	13/18367	0.559772590410071	0.806139568824084	UBC	1
GO:0031432	titin binding	1/1123	13/18367	0.559772590410071	0.806139568824084	CALM1	1
GO:0032036	myosin heavy chain binding	1/1123	13/18367	0.559772590410071	0.806139568824084	MYL12B	1
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	JMJD1C	1
GO:0052650	NADP-retinol dehydrogenase activity	1/1123	13/18367	0.559772590410071	0.806139568824084	DHRS3	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/1123	13/18367	0.559772590410071	0.806139568824084	CKS1B	1
GO:0070679	inositol 1,4,5 trisphosphate binding	1/1123	13/18367	0.559772590410071	0.806139568824084	ITPR2	1
GO:0070700	BMP receptor binding	1/1123	13/18367	0.559772590410071	0.806139568824084	BMP7	1
GO:0030145	manganese ion binding	4/1123	65/18367	0.567869790944404	0.816578085035152	EXTL2/B4GALT1/DCP2/MGAT1	4
GO:0008157	protein phosphatase 1 binding	2/1123	31/18367	0.573200841911944	0.821562222129623	PPP1R9A/PHACTR4	2
GO:0002039	p53 binding	4/1123	66/18367	0.580104975539904	0.821562222129623	BRD4/MDM4/CREBBP/USP10	4
GO:0005506	iron ion binding	9/1123	151/18367	0.58020308927115	0.821562222129623	FTH1/P3H1/TET2/P3H2/PLOD1/FBXL5/P4HTM/CYP20A1/FTL	9
GO:0016763	pentosyltransferase activity	3/1123	49/18367	0.583257038647936	0.821562222129623	GXYLT1/TNKS2/PARP14	3
GO:0019212	phosphatase inhibitor activity	3/1123	49/18367	0.583257038647936	0.821562222129623	PHACTR2/BOD1L1/PPP1R14B	3
GO:0004065	arylsulfatase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	STS	1
GO:0004298	threonine-type endopeptidase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	PSMB5	1
GO:0004707	MAP kinase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	MAPK14	1
GO:0005313	L-glutamate transmembrane transporter activity	1/1123	14/18367	0.586708156552028	0.821562222129623	SLC1A3	1
GO:0005451	monovalent cation:proton antiporter activity	1/1123	14/18367	0.586708156552028	0.821562222129623	SLC9A1	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	LYPLA1	1
GO:0015562	efflux transmembrane transporter activity	1/1123	14/18367	0.586708156552028	0.821562222129623	GJA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/1123	14/18367	0.586708156552028	0.821562222129623	MIF	1
GO:0017110	nucleoside-diphosphatase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	CANT1	1
GO:0019992	diacylglycerol binding	1/1123	14/18367	0.586708156552028	0.821562222129623	RAPGEF2	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	PDE10A	1
GO:0098599	palmitoyl hydrolase activity	1/1123	14/18367	0.586708156552028	0.821562222129623	LYPLA1	1
GO:0140666	annealing activity	1/1123	14/18367	0.586708156552028	0.821562222129623	ANXA1	1
GO:0001222	transcription corepressor binding	2/1123	32/18367	0.59067613533545	0.823414189175876	SUZ12/ZNF644	2
GO:0001223	transcription coactivator binding	2/1123	32/18367	0.59067613533545	0.823414189175876	RPL23/CREBBP	2
GO:0008017	microtubule binding	16/1123	271/18367	0.594427246407651	0.823414189175876	GAPDH/CLIP1/MACF1/DST/RPS3/CEP350/EML4/KIF5B/LRPPRC/HOOK2/TRPV4/CAMSAP2/ZNF207/NUSAP1/BIRC5/CAPN6	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	10/1123	170/18367	0.596365276719803	0.823414189175876	ASPH/P3H1/TET2/P3H2/P4HB/KDM5A/DEGS1/PLOD1/P4HTM/CYP20A1	10
GO:0000993	RNA polymerase II complex binding	3/1123	50/18367	0.597131073625747	0.823414189175876	BRD4/NCOA3/AGO2	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/1123	50/18367	0.597131073625747	0.823414189175876	CCND1/CKS1B/CDKN1C	3
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	3/1123	50/18367	0.597131073625747	0.823414189175876	MAN2A1/TLR3/TDG	3
GO:0030159	signaling receptor complex adaptor activity	3/1123	50/18367	0.597131073625747	0.823414189175876	DLG5/SORBS1/GNB4	3
GO:0008080	N-acetyltransferase activity	4/1123	68/18367	0.603966880605574	0.823414189175876	NCOA3/HGSNAT/SAT1/CREBBP	4
GO:0031369	translation initiation factor binding	2/1123	33/18367	0.60761224454268	0.823414189175876	CELF1/EIF2S2	2
GO:0001846	opsonin binding	1/1123	15/18367	0.611997032495583	0.823414189175876	ITGAV	1
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/1123	15/18367	0.611997032495583	0.823414189175876	ALDH4A1	1
GO:0004953	icosanoid receptor activity	1/1123	15/18367	0.611997032495583	0.823414189175876	HPGD	1
GO:0005161	platelet-derived growth factor receptor binding	1/1123	15/18367	0.611997032495583	0.823414189175876	PDGFD	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/1123	15/18367	0.611997032495583	0.823414189175876	GABRE	1
GO:0008020	G protein-coupled photoreceptor activity	1/1123	15/18367	0.611997032495583	0.823414189175876	OPN3	1
GO:0010851	cyclase regulator activity	1/1123	15/18367	0.611997032495583	0.823414189175876	CALM1	1
GO:0019215	intermediate filament binding	1/1123	15/18367	0.611997032495583	0.823414189175876	PKP2	1
GO:0030548	acetylcholine receptor regulator activity	1/1123	15/18367	0.611997032495583	0.823414189175876	LY6E	1
GO:0030553	cGMP binding	1/1123	15/18367	0.611997032495583	0.823414189175876	PDE10A	1
GO:0034483	heparan sulfate sulfotransferase activity	1/1123	15/18367	0.611997032495583	0.823414189175876	HS6ST2	1
GO:0042809	vitamin D receptor binding	1/1123	15/18367	0.611997032495583	0.823414189175876	MED13	1
GO:0043138	3'-5' DNA helicase activity	1/1123	15/18367	0.611997032495583	0.823414189175876	NAV2	1
GO:0051139	metal ion:proton antiporter activity	1/1123	15/18367	0.611997032495583	0.823414189175876	SLC9A1	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/1123	15/18367	0.611997032495583	0.823414189175876	CFLAR	1
GO:0099602	neurotransmitter receptor regulator activity	1/1123	15/18367	0.611997032495583	0.823414189175876	LY6E	1
GO:1901611	phosphatidylglycerol binding	1/1123	15/18367	0.611997032495583	0.823414189175876	MME	1
GO:1990825	sequence-specific mRNA binding	1/1123	15/18367	0.611997032495583	0.823414189175876	SRSF3	1
GO:0016791	phosphatase activity	16/1123	275/18367	0.61811611455804	0.827996343665271	PTPRF/PLPP3/SGPP1/DLG1/PTPN14/PTPRA/PDP2/PTP4A1/ATP1A1/PTPRM/PPP4R1/DNAJC6/PTPRK/G6PC3/PPP3CA/CDKN3	16
GO:0004879	nuclear receptor activity	3/1123	52/18367	0.623958208444982	0.827996343665271	NR3C1/ESRRG/NR2F2	3
GO:0016597	amino acid binding	3/1123	52/18367	0.623958208444982	0.827996343665271	GLDC/SLC1A3/GCHFR	3
GO:0016830	carbon-carbon lyase activity	3/1123	52/18367	0.623958208444982	0.827996343665271	ALDOA/UXS1/PISD	3
GO:0098531	ligand-activated transcription factor activity	3/1123	52/18367	0.623958208444982	0.827996343665271	NR3C1/ESRRG/NR2F2	3
GO:0016741	transferase activity, transferring one-carbon groups	13/1123	225/18367	0.623990265572258	0.827996343665271	ASH1L/METTL7A/KMT2C/DNMT3A/NSD1/PRMT9/MTR/RNMT/SETD2/KMT2A/PCMTD1/SUZ12/TARBP1	13
GO:0015020	glucuronosyltransferase activity	2/1123	34/18367	0.624009718458754	0.827996343665271	CHPF/B3GAT3	2
GO:0016831	carboxy-lyase activity	2/1123	34/18367	0.624009718458754	0.827996343665271	UXS1/PISD	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/1123	34/18367	0.624009718458754	0.827996343665271	DICER1/AGO2	2
GO:0045505	dynein intermediate chain binding	2/1123	34/18367	0.624009718458754	0.827996343665271	DYNLL1/DYNC1H1	2
GO:0008236	serine-type peptidase activity	11/1123	191/18367	0.624980538896985	0.828142256775344	CPD/CTSC/DPP4/PRSS8/FURIN/ST14/TPP1/PCSK7/CTSA/PRSS12/DPP7	11
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/1123	16/18367	0.635739803447385	0.829095629802775	ALDH4A1	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/1123	16/18367	0.635739803447385	0.829095629802775	CAPN7	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/1123	16/18367	0.635739803447385	0.829095629802775	SLC22A11	1
GO:0016004	phospholipase activator activity	1/1123	16/18367	0.635739803447385	0.829095629802775	GM2A	1
GO:0016208	AMP binding	1/1123	16/18367	0.635739803447385	0.829095629802775	ACSS1	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/1123	16/18367	0.635739803447385	0.829095629802775	AOC1	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1123	16/18367	0.635739803447385	0.829095629802775	DICER1	1
GO:0022821	potassium ion antiporter activity	1/1123	16/18367	0.635739803447385	0.829095629802775	SLC9A1	1
GO:0050700	CARD domain binding	1/1123	16/18367	0.635739803447385	0.829095629802775	MAVS	1
GO:0070492	oligosaccharide binding	1/1123	16/18367	0.635739803447385	0.829095629802775	CHID1	1
GO:1990380	Lys48-specific deubiquitinase activity	1/1123	16/18367	0.635739803447385	0.829095629802775	USP9X	1
GO:0050661	NADP binding	3/1123	53/18367	0.636904023310032	0.829095629802775	GAPDH/IDH1/CAT	3
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/1123	53/18367	0.636904023310032	0.829095629802775	SLC6A4/SLC5A3/SLC16A1	3
GO:0031491	nucleosome binding	4/1123	71/18367	0.638170704364816	0.82962191567426	ARID1A/SMARCC1/ACTB/HNRNPC	4
GO:0008081	phosphoric diester hydrolase activity	5/1123	89/18367	0.641085460497184	0.832286387312134	PLD3/PDIA3/SMPD1/PDE10A/PDE7A	5
GO:0042578	phosphoric ester hydrolase activity	21/1123	366/18367	0.650880519089441	0.834026009080252	PTPRF/PLPP3/PLD3/SGPP1/DLG1/PTPN14/PTPRA/PDIA3/SMPD1/PDP2/PTP4A1/ATP1A1/PTPRM/PPP4R1/DNAJC6/PTPRK/G6PC3/PPP3CA/PDE10A/PDE7A/CDKN3	21
GO:0034061	DNA polymerase activity	2/1123	36/18367	0.655200451276314	0.834026009080252	PTGES3/REV3L	2
GO:0042605	peptide antigen binding	2/1123	36/18367	0.655200451276314	0.834026009080252	DHCR24/TAPBP	2
GO:0004659	prenyltransferase activity	1/1123	17/18367	0.658030915688058	0.834026009080252	PTAR1	1
GO:0005005	transmembrane-ephrin receptor activity	1/1123	17/18367	0.658030915688058	0.834026009080252	EPHB4	1
GO:0005149	interleukin-1 receptor binding	1/1123	17/18367	0.658030915688058	0.834026009080252	ERAP1	1
GO:0008525	phosphatidylcholine transporter activity	1/1123	17/18367	0.658030915688058	0.834026009080252	ABCA1	1
GO:0008574	plus-end-directed microtubule motor activity	1/1123	17/18367	0.658030915688058	0.834026009080252	KIF5B	1
GO:0009881	photoreceptor activity	1/1123	17/18367	0.658030915688058	0.834026009080252	OPN3	1
GO:0015108	chloride transmembrane transporter activity	1/1123	17/18367	0.658030915688058	0.834026009080252	SLC26A2	1
GO:0015377	cation:chloride symporter activity	1/1123	17/18367	0.658030915688058	0.834026009080252	SLC6A4	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/1123	17/18367	0.658030915688058	0.834026009080252	FTH1	1
GO:0017081	chloride channel regulator activity	1/1123	17/18367	0.658030915688058	0.834026009080252	WNK1	1
GO:0030169	low-density lipoprotein particle binding	1/1123	17/18367	0.658030915688058	0.834026009080252	COLEC12	1
GO:0032393	MHC class I receptor activity	1/1123	17/18367	0.658030915688058	0.834026009080252	MR1	1
GO:0043395	heparan sulfate proteoglycan binding	1/1123	17/18367	0.658030915688058	0.834026009080252	LRP1	1
GO:0050780	dopamine receptor binding	1/1123	17/18367	0.658030915688058	0.834026009080252	GNA12	1
GO:0070628	proteasome binding	1/1123	17/18367	0.658030915688058	0.834026009080252	WFS1	1
GO:0033293	monocarboxylic acid binding	4/1123	73/18367	0.659874802488144	0.83526257893894	PSAP/GSTP1/NR2F2/ACOX1	4
GO:0042056	chemoattractant activity	2/1123	37/18367	0.670003605969059	0.846060371754243	MIF/HMGB1	2
GO:0045309	protein phosphorylated amino acid binding	3/1123	56/18367	0.673846556814903	0.846060371754243	PFN1/RASA1/YWHAE	3
GO:0004708	MAP kinase kinase activity	1/1123	18/18367	0.678959050929601	0.846060371754243	MAPK14	1
GO:0005229	intracellular calcium activated chloride channel activity	1/1123	18/18367	0.678959050929601	0.846060371754243	ANO6	1
GO:0008569	minus-end-directed microtubule motor activity	1/1123	18/18367	0.678959050929601	0.846060371754243	DYNC1H1	1
GO:0046527	glucosyltransferase activity	1/1123	18/18367	0.678959050929601	0.846060371754243	ALG10B	1
GO:0048038	quinone binding	1/1123	18/18367	0.678959050929601	0.846060371754243	AOC1	1
GO:0050811	GABA receptor binding	1/1123	18/18367	0.678959050929601	0.846060371754243	TRAK2	1
GO:0060229	lipase activator activity	1/1123	18/18367	0.678959050929601	0.846060371754243	GM2A	1
GO:0061778	intracellular chloride channel activity	1/1123	18/18367	0.678959050929601	0.846060371754243	ANO6	1
GO:0070122	isopeptidase activity	1/1123	18/18367	0.678959050929601	0.846060371754243	EIF3H	1
GO:0099095	ligand-gated anion channel activity	1/1123	18/18367	0.678959050929601	0.846060371754243	GABRE	1
GO:0019003	GDP binding	4/1123	75/18367	0.680680094086245	0.846412271775304	RAN/RAB31/RHOA/RAB2A	4
GO:0016298	lipase activity	7/1123	129/18367	0.681001141740213	0.846412271775304	PLD3/LIPA/PDIA3/SMPD1/NCEH1/LYPLA1/PLBD1	7
GO:0004520	endodeoxyribonuclease activity	2/1123	38/18367	0.684287501672786	0.846569071156569	DICER1/RPS3	2
GO:0005501	retinoid binding	2/1123	38/18367	0.684287501672786	0.846569071156569	NR2F2/OPN3	2
GO:0019840	isoprenoid binding	2/1123	38/18367	0.684287501672786	0.846569071156569	NR2F2/OPN3	2
GO:0016874	ligase activity	9/1123	165/18367	0.685404558052674	0.846569071156569	SLC27A2/ACSS1/IARS2/AASDH/SLC27A6/UBA1/ACSL3/RIMKLB/UBA6	9
GO:0004536	deoxyribonuclease activity	3/1123	57/18367	0.685527345562336	0.846569071156569	DICER1/PLD3/RPS3	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3/1123	58/18367	0.696892409102773	0.847491038719387	SMS/GSTP1/PTAR1	3
GO:0004402	histone acetyltransferase activity	2/1123	39/18367	0.698060235969566	0.847491038719387	NCOA3/CREBBP	2
GO:0005504	fatty acid binding	2/1123	39/18367	0.698060235969566	0.847491038719387	GSTP1/ACOX1	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/1123	39/18367	0.698060235969566	0.847491038719387	DLG1/AK3	2
GO:0000339	RNA cap binding	1/1123	19/18367	0.698607477863279	0.847491038719387	AGO2	1
GO:0004129	cytochrome-c oxidase activity	1/1123	19/18367	0.698607477863279	0.847491038719387	COX6A1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/1123	19/18367	0.698607477863279	0.847491038719387	GALNT11	1
GO:0004745	NAD-retinol dehydrogenase activity	1/1123	19/18367	0.698607477863279	0.847491038719387	DHRS3	1
GO:0004890	GABA-A receptor activity	1/1123	19/18367	0.698607477863279	0.847491038719387	GABRE	1
GO:0005003	ephrin receptor activity	1/1123	19/18367	0.698607477863279	0.847491038719387	EPHB4	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/1123	19/18367	0.698607477863279	0.847491038719387	SH3PXD2A	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/1123	19/18367	0.698607477863279	0.847491038719387	ALDH4A1	1
GO:0016918	retinal binding	1/1123	19/18367	0.698607477863279	0.847491038719387	OPN3	1
GO:0052742	phosphatidylinositol kinase activity	1/1123	19/18367	0.698607477863279	0.847491038719387	ATM	1
GO:0000287	magnesium ion binding	12/1123	221/18367	0.705518651627399	0.854797157261407	ATP10D/S100P/RPS6KA5/ENO1/WNK1/DHX36/RAN/MAST4/IDH1/ATP11B/TDG/TKT	12
GO:0042287	MHC protein binding	2/1123	40/18367	0.711330857455735	0.859036507795432	CD74/TAPBP	2
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/1123	20/18367	0.717054382286624	0.859036507795432	REST	1
GO:0001972	retinoic acid binding	1/1123	20/18367	0.717054382286624	0.859036507795432	NR2F2	1
GO:0016408	C-acyltransferase activity	1/1123	20/18367	0.717054382286624	0.859036507795432	SPTLC3	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/1123	20/18367	0.717054382286624	0.859036507795432	CTSC	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/1123	20/18367	0.717054382286624	0.859036507795432	COX6A1	1
GO:0042288	MHC class I protein binding	1/1123	20/18367	0.717054382286624	0.859036507795432	TAPBP	1
GO:0050145	nucleoside monophosphate kinase activity	1/1123	20/18367	0.717054382286624	0.859036507795432	DLG1	1
GO:0070300	phosphatidic acid binding	1/1123	20/18367	0.717054382286624	0.859036507795432	RAPGEF2	1
GO:0019001	guanyl nucleotide binding	22/1123	398/18367	0.719136261237284	0.85933165114594	EEF1A1/ARHGAP5/SLC19A1/HSP90AB1/GNAQ/GNA12/RHOV/RAB6A/RHOBTB3/ARL5B/AK3/RHOBTB1/RAN/RAB13/RANBP17/RAB31/INSR/PDE10A/ARF4/RHOA/ARF5/RAB2A	22
GO:0032561	guanyl ribonucleotide binding	22/1123	398/18367	0.719136261237284	0.85933165114594	EEF1A1/ARHGAP5/SLC19A1/HSP90AB1/GNAQ/GNA12/RHOV/RAB6A/RHOBTB3/ARL5B/AK3/RHOBTB1/RAN/RAB13/RANBP17/RAB31/INSR/PDE10A/ARF4/RHOA/ARF5/RAB2A	22
GO:0004540	ribonuclease activity	6/1123	116/18367	0.719980572581733	0.85933165114594	DICER1/CNOT6L/XRN1/DCP2/AGO2/SND1	6
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/1123	41/18367	0.724109219395651	0.863188437495187	NCOA3/CREBBP	2
GO:0001664	G protein-coupled receptor binding	16/1123	295/18367	0.725675165375346	0.863984540954311	ITGB4/WLS/RNF43/ADRB1/ZNRF3/CALM1/GNAQ/GNA12/ATP2A2/RYK/DVL3/S1PR2/EDNRB/DNAJA1/RAPGEF2/HSPA1A	16
GO:0004527	exonuclease activity	4/1123	80/18367	0.728721139347233	0.866538610694732	PLD3/CNOT6L/XRN1/DCP2	4
GO:0001614	purinergic nucleotide receptor activity	1/1123	21/18367	0.734373177113687	0.867895572952539	P2RX4	1
GO:0004407	histone deacetylase activity	1/1123	21/18367	0.734373177113687	0.867895572952539	MIER1	1
GO:0005385	zinc ion transmembrane transporter activity	1/1123	21/18367	0.734373177113687	0.867895572952539	SLC39A10	1
GO:0016502	nucleotide receptor activity	1/1123	21/18367	0.734373177113687	0.867895572952539	P2RX4	1
GO:0019200	carbohydrate kinase activity	1/1123	21/18367	0.734373177113687	0.867895572952539	GNE	1
GO:0051539	4 iron, 4 sulfur cluster binding	2/1123	42/18367	0.736405847689095	0.869229969910319	IREB2/REV3L	2
GO:0005246	calcium channel regulator activity	2/1123	43/18367	0.748231821951548	0.875283330109823	CALM1/YWHAE	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/1123	43/18367	0.748231821951548	0.875283330109823	SNX13/SH3PXD2A	2
GO:0005540	hyaluronic acid binding	1/1123	22/18367	0.750632793493351	0.875283330109823	HMMR	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/1123	22/18367	0.750632793493351	0.875283330109823	DHRS3	1
GO:0009975	cyclase activity	1/1123	22/18367	0.750632793493351	0.875283330109823	ADCY7	1
GO:0015106	bicarbonate transmembrane transporter activity	1/1123	22/18367	0.750632793493351	0.875283330109823	SLC26A2	1
GO:0016917	GABA receptor activity	1/1123	22/18367	0.750632793493351	0.875283330109823	GABRE	1
GO:0017075	syntaxin-1 binding	1/1123	22/18367	0.750632793493351	0.875283330109823	SLC6A4	1
GO:0033558	protein deacetylase activity	1/1123	22/18367	0.750632793493351	0.875283330109823	MIER1	1
GO:0120020	cholesterol transfer activity	1/1123	22/18367	0.750632793493351	0.875283330109823	ABCA1	1
GO:0001784	phosphotyrosine residue binding	2/1123	44/18367	0.759598668599699	0.884506400872688	PFN1/RASA1	2
GO:0004529	exodeoxyribonuclease activity	1/1123	23/18367	0.765897954186018	0.884506400872688	PLD3	1
GO:0005248	voltage-gated sodium channel activity	1/1123	23/18367	0.765897954186018	0.884506400872688	PKD2	1
GO:0016849	phosphorus-oxygen lyase activity	1/1123	23/18367	0.765897954186018	0.884506400872688	ADCY7	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1123	23/18367	0.765897954186018	0.884506400872688	PLD3	1
GO:0047617	acyl-CoA hydrolase activity	1/1123	23/18367	0.765897954186018	0.884506400872688	ABCD3	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/1123	23/18367	0.765897954186018	0.884506400872688	TAB2	1
GO:0120015	sterol transfer activity	1/1123	23/18367	0.765897954186018	0.884506400872688	ABCA1	1
GO:0004620	phospholipase activity	5/1123	104/18367	0.769638731638299	0.886649008198322	PLD3/PDIA3/SMPD1/LYPLA1/PLBD1	5
GO:0005245	voltage-gated calcium channel activity	2/1123	45/18367	0.770518264920787	0.886649008198322	ITGAV/PKD2	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/1123	45/18367	0.770518264920787	0.886649008198322	DICER1/AGO2	2
GO:0005525	GTP binding	20/1123	377/18367	0.776060979186531	0.887211243414147	EEF1A1/ARHGAP5/HSP90AB1/GNAQ/GNA12/RHOV/RAB6A/RHOBTB3/ARL5B/AK3/RHOBTB1/RAN/RAB13/RANBP17/RAB31/INSR/ARF4/RHOA/ARF5/RAB2A	20
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6/1123	124/18367	0.776934642536177	0.887211243414147	LDHA/DHRS3/IDH1/FASN/HPGD/LDHB	6
GO:0005126	cytokine receptor binding	14/1123	271/18367	0.77942867115892	0.887211243414147	IL6ST/CSH1/PRLR/MIF/TGFBR3/LIFR/TGFBR1/ADAM17/SMAD2/CFLAR/FEM1B/EFNA5/ERAP1/SMURF2	14
GO:0004622	lysophospholipase activity	1/1123	24/18367	0.780229430278969	0.887211243414147	LYPLA1	1
GO:0008171	O-methyltransferase activity	1/1123	24/18367	0.780229430278969	0.887211243414147	PCMTD1	1
GO:0043495	protein-membrane adaptor activity	1/1123	24/18367	0.780229430278969	0.887211243414147	SYNE2	1
GO:0070003	threonine-type peptidase activity	1/1123	24/18367	0.780229430278969	0.887211243414147	PSMB5	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/1123	24/18367	0.780229430278969	0.887211243414147	BMP7	1
GO:0070840	dynein complex binding	1/1123	24/18367	0.780229430278969	0.887211243414147	TPR	1
GO:0120014	phospholipid transfer activity	1/1123	24/18367	0.780229430278969	0.887211243414147	PLEKHA8	1
GO:0140375	immune receptor activity	7/1123	144/18367	0.784452468072854	0.890960182155945	CSF3R/IL6ST/PRLR/CD74/LIFR/IL10RB/MR1	7
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/1123	47/18367	0.791064463927848	0.89231071358982	PTP4A1/CDKN3	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/1123	47/18367	0.791064463927848	0.89231071358982	ADRB1/GABRE	2
GO:0003887	DNA-directed DNA polymerase activity	1/1123	25/18367	0.793684282255021	0.89231071358982	REV3L	1
GO:0016289	CoA hydrolase activity	1/1123	25/18367	0.793684282255021	0.89231071358982	ABCD3	1
GO:0030247	polysaccharide binding	1/1123	25/18367	0.793684282255021	0.89231071358982	AGL	1
GO:0035035	histone acetyltransferase binding	1/1123	25/18367	0.793684282255021	0.89231071358982	GLI3	1
GO:0051536	iron-sulfur cluster binding	3/1123	68/18367	0.793771018211117	0.89231071358982	RPS3/IREB2/REV3L	3
GO:0051540	metal cluster binding	3/1123	68/18367	0.793771018211117	0.89231071358982	RPS3/IREB2/REV3L	3
GO:0051219	phosphoprotein binding	4/1123	88/18367	0.793989574670359	0.89231071358982	PFN1/RASA1/YWHAE/PKD2	4
GO:0004521	endoribonuclease activity	3/1123	69/18367	0.801870430697457	0.90011593270823	DICER1/AGO2/SND1	3
GO:0004364	glutathione transferase activity	1/1123	26/18367	0.80631608636731	0.901840944708819	GSTP1	1
GO:0038187	pattern recognition receptor activity	1/1123	26/18367	0.80631608636731	0.901840944708819	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/1123	26/18367	0.80631608636731	0.901840944708819	SLC26A2	1
GO:0001098	basal transcription machinery binding	3/1123	70/18367	0.809701062077637	0.901840944708819	BRD4/NCOA3/AGO2	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/1123	70/18367	0.809701062077637	0.901840944708819	BRD4/NCOA3/AGO2	3
GO:0032813	tumor necrosis factor receptor superfamily binding	2/1123	49/18367	0.809969413958857	0.901840944708819	CFLAR/FEM1B	2
GO:0034212	peptide N-acetyltransferase activity	2/1123	49/18367	0.809969413958857	0.901840944708819	NCOA3/CREBBP	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/1123	71/18367	0.817268577859085	0.908873546906394	ASAH1/MIER1/CAT	3
GO:0015491	cation:cation antiporter activity	1/1123	27/18367	0.818175147215111	0.908873546906394	SLC9A1	1
GO:0000049	tRNA binding	3/1123	72/18367	0.824578764631051	0.913854486668245	EEF1A1/IARS2/NEMF	3
GO:0003924	GTPase activity	17/1123	337/18367	0.826245652760401	0.913854486668245	EEF1A1/ARHGAP5/GNAQ/RASA1/GNA12/RHOV/RAB6A/RHOBTB3/ARL5B/RHOBTB1/RAN/RAB13/RAB31/ARF4/RHOA/ARF5/RAB2A	17
GO:0003953	NAD+ nucleosidase activity	1/1123	28/18367	0.8293086973611	0.913854486668245	TLR3	1
GO:0004629	phospholipase C activity	1/1123	28/18367	0.8293086973611	0.913854486668245	PDIA3	1
GO:0017056	structural constituent of nuclear pore	1/1123	28/18367	0.8293086973611	0.913854486668245	TPR	1
GO:0046875	ephrin receptor binding	1/1123	28/18367	0.8293086973611	0.913854486668245	EFNA5	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/1123	28/18367	0.8293086973611	0.913854486668245	SNX14	1
GO:0016410	N-acyltransferase activity	4/1123	94/18367	0.834154625965749	0.916969538658053	NCOA3/HGSNAT/SAT1/CREBBP	4
GO:0031593	polyubiquitin modification-dependent protein binding	2/1123	52/18367	0.835468109652295	0.916969538658053	AGL/TAB2	2
GO:0019905	syntaxin binding	3/1123	74/18367	0.838450759501913	0.916969538658053	ABCA1/SLC6A4/SYT7	3
GO:0004033	aldo-keto reductase (NADP) activity	1/1123	29/18367	0.83976108477936	0.916969538658053	DHRS3	1
GO:0005231	excitatory extracellular ligand-gated ion channel activity	1/1123	29/18367	0.83976108477936	0.916969538658053	P2RX4	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/1123	29/18367	0.83976108477936	0.916969538658053	ALDH4A1	1
GO:0033612	receptor serine/threonine kinase binding	1/1123	29/18367	0.83976108477936	0.916969538658053	BMP7	1
GO:0051059	NF-kappaB binding	1/1123	29/18367	0.83976108477936	0.916969538658053	NPM1	1
GO:0004252	serine-type endopeptidase activity	8/1123	174/18367	0.841516850849066	0.917844909882995	CTSC/DPP4/PRSS8/FURIN/ST14/TPP1/PCSK7/PRSS12	8
GO:0017069	snRNA binding	2/1123	53/18367	0.843254936567678	0.918699036215296	EIF5A/LSM3	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	6/1123	136/18367	0.845356405683643	0.919946676773376	LDHA/DHRS3/IDH1/FASN/HPGD/LDHB	6
GO:0003724	RNA helicase activity	3/1123	77/18367	0.857477867378416	0.931416192302043	DDX17/DHX36/MOV10	3
GO:0030170	pyridoxal phosphate binding	2/1123	55/18367	0.857832376693981	0.931416192302043	GLDC/SPTLC3	2
GO:0070279	vitamin B6 binding	2/1123	56/18367	0.864646666319132	0.936557317167337	GLDC/SPTLC3	2
GO:0008175	tRNA methyltransferase activity	1/1123	32/18367	0.867435103530247	0.936557317167337	TARBP1	1
GO:0030515	snoRNA binding	1/1123	32/18367	0.867435103530247	0.936557317167337	PRKDC	1
GO:0050699	WW domain binding	1/1123	32/18367	0.867435103530247	0.936557317167337	RAPGEF2	1
GO:0051721	protein phosphatase 2A binding	1/1123	32/18367	0.867435103530247	0.936557317167337	BOD1L1	1
GO:0008186	ATP-dependent activity, acting on RNA	3/1123	79/18367	0.869045976742165	0.937244652047043	DDX17/DHX36/MOV10	3
GO:0001530	lipopolysaccharide binding	1/1123	33/18367	0.875554567873609	0.942151559613436	HMGB1	1
GO:0051427	hormone receptor binding	1/1123	33/18367	0.875554567873609	0.942151559613436	CSH1	1
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	22/1123	450/18367	0.887404248136265	0.953835627605684	PBX1/NFAT5/NR3C1/ESRRG/ATF6/TFDP2/CREB3L2/GTF2I/MEIS2/KLF10/RBPJ/NFIB/ZFAT/SMAD2/TFCP2L1/NFATC3/CREBRF/REL/ISL1/FOXO4/PLAG1/ELK4	22
GO:0022836	gated channel activity	16/1123	340/18367	0.890077930603585	0.954307163775085	ITGAV/GABRE/ANO6/TMEM150C/P2RX4/ITPR2/MCOLN3/TMC5/KCNN4/TMEM37/VDAC1/CLCN3/TRPV4/CLIC3/PKD2/TMEM63A	16
GO:0000175	3'-5'-exoribonuclease activity	1/1123	35/18367	0.890333200423294	0.954307163775085	CNOT6L	1
GO:1990782	protein tyrosine kinase binding	4/1123	105/18367	0.890818953295246	0.954307163775085	ITGB1/PTPN14/EIF3A/BMPR2	4
GO:0052689	carboxylic ester hydrolase activity	6/1123	147/18367	0.892080339231407	0.954595424183107	PGAP1/LIPA/IARS2/NCEH1/LYPLA1/APMAP	6
GO:0050660	flavin adenine dinucleotide binding	3/1123	85/18367	0.898918245725417	0.959683889900519	DHCR24/ERO1B/ACOX1	3
GO:0098960	postsynaptic neurotransmitter receptor activity	2/1123	62/18367	0.899599937710953	0.959683889900519	ADRB1/GABRE	2
GO:0001216	DNA-binding transcription activator activity	22/1123	456/18367	0.900197992596541	0.959683889900519	PBX1/NFAT5/NR3C1/ESRRG/ATF6/TFDP2/CREB3L2/GTF2I/MEIS2/KLF10/RBPJ/NFIB/ZFAT/SMAD2/TFCP2L1/NFATC3/CREBRF/REL/ISL1/FOXO4/PLAG1/ELK4	22
GO:0004518	nuclease activity	9/1123	210/18367	0.901299749912528	0.959683889900519	N4BP2/DICER1/PLD3/RPS3/CNOT6L/XRN1/DCP2/AGO2/SND1	9
GO:0004519	endonuclease activity	5/1123	129/18367	0.901823530634168	0.959683889900519	N4BP2/DICER1/RPS3/AGO2/SND1	5
GO:0019213	deacetylase activity	1/1123	38/18367	0.909278987346297	0.966548492626672	MIER1	1
GO:0008173	RNA methyltransferase activity	2/1123	65/18367	0.913734230137704	0.97021228409765	RNMT/TARBP1	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	1/1123	39/18367	0.914837375540422	0.970312629845519	POLR2J3	1
GO:0003925	G protein activity	1/1123	40/18367	0.920055491388747	0.97429497895099	RHOA	1
GO:0099094	ligand-gated cation channel activity	4/1123	113/18367	0.92061760485078	0.97429497895099	P2RX4/ITPR2/MCOLN3/PKD2	4
GO:0005216	ion channel activity	20/1123	432/18367	0.924779481693624	0.975664353681369	ITGAV/GABRE/ANO6/TMEM150C/P2RX4/ITPR2/MCOLN3/TMC5/SEC61A1/KCNN4/TMEM37/TRPM7/VDAC1/CLCN3/TRPV4/CLDN4/CLIC3/PKD2/ANXA2/TMEM63A	20
GO:0004812	aminoacyl-tRNA ligase activity	1/1123	41/18367	0.924954148188575	0.975664353681369	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/1123	41/18367	0.924954148188575	0.975664353681369	IARS2	1
GO:0003777	microtubule motor activity	2/1123	69/18367	0.929689246928083	0.976775318094346	DYNC1H1/KIF5B	2
GO:0030547	signaling receptor inhibitor activity	1/1123	43/18367	0.933870055445947	0.976775318094346	LY6E	1
GO:0034062	5'-3' RNA polymerase activity	1/1123	43/18367	0.933870055445947	0.976775318094346	POLR2J3	1
GO:0097747	RNA polymerase activity	1/1123	43/18367	0.933870055445947	0.976775318094346	POLR2J3	1
GO:0008083	growth factor activity	6/1123	162/18367	0.936033149696519	0.976775318094346	CSH1/GRN/EFEMP1/BMP7/JAG1/PDGFD	6
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/1123	44/18367	0.93792287839586	0.976775318094346	MAPK14	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/1123	44/18367	0.93792287839586	0.976775318094346	GABRE	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	2/1123	72/18367	0.939779184692393	0.976775318094346	COX6A1/UQCRH	2
GO:0015267	channel activity	22/1123	480/18367	0.94017274546504	0.976775318094346	ITGAV/GABRE/GJA1/ANO6/TMEM150C/P2RX4/ITPR2/MCOLN3/TMC5/SEC61A1/KCNN4/TMEM37/TRPM7/VDAC1/GJA5/CLCN3/TRPV4/CLDN4/CLIC3/PKD2/ANXA2/TMEM63A	22
GO:0022803	passive transmembrane transporter activity	22/1123	481/18367	0.94149274981272	0.976775318094346	ITGAV/GABRE/GJA1/ANO6/TMEM150C/P2RX4/ITPR2/MCOLN3/TMC5/SEC61A1/KCNN4/TMEM37/TRPM7/VDAC1/GJA5/CLCN3/TRPV4/CLDN4/CLIC3/PKD2/ANXA2/TMEM63A	22
GO:0015276	ligand-gated ion channel activity	5/1123	143/18367	0.942065032719227	0.976775318094346	GABRE/P2RX4/ITPR2/MCOLN3/PKD2	5
GO:0022834	ligand-gated channel activity	5/1123	143/18367	0.942065032719227	0.976775318094346	GABRE/P2RX4/ITPR2/MCOLN3/PKD2	5
GO:0046982	protein heterodimerization activity	14/1123	328/18367	0.9427060703558	0.976775318094346	TENM3/ITGB1/ADRB1/ERBB3/HEXA/YWHAE/ATF6/P4HB/TOP2B/ATP1A1/CAV1/RAN/ALG2/ERBB2	14
GO:0005230	extracellular ligand-gated ion channel activity	2/1123	73/18367	0.942825429166383	0.976775318094346	GABRE/P2RX4	2
GO:0106306	protein serine phosphatase activity	2/1123	73/18367	0.942825429166383	0.976775318094346	PPP3CA/CDKN3	2
GO:0106307	protein threonine phosphatase activity	2/1123	73/18367	0.942825429166383	0.976775318094346	PPP3CA/CDKN3	2
GO:0004722	protein serine/threonine phosphatase activity	3/1123	98/18367	0.943602937989758	0.976775318094346	PDP2/PPP3CA/CDKN3	3
GO:0005179	hormone activity	4/1123	122/18367	0.94525214594325	0.976775318094346	FBN1/CSH1/COPA/INSL4	4
GO:0005272	sodium channel activity	1/1123	46/18367	0.945299190380287	0.976775318094346	PKD2	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/1123	48/18367	0.951799699462945	0.98138404167562	RIMKLB	1
GO:0070888	E-box binding	1/1123	48/18367	0.951799699462945	0.98138404167562	SREBF2	1
GO:0046906	tetrapyrrole binding	5/1123	149/18367	0.954209029004409	0.98281486713302	LMBRD1/MTR/CYP20A1/CAT/CYCS	5
GO:0030971	receptor tyrosine kinase binding	2/1123	78/18367	0.955979906425601	0.983585743295645	PTPN14/EIF3A	2
GO:0030546	signaling receptor activator activity	22/1123	495/18367	0.957530620155376	0.98412869293747	FBN1/CSH1/GRN/EFEMP1/SEMA6D/SEMA6A/APP/MIF/DPP4/SEMA3F/FAM3B/BMP7/COPA/JAG1/SEMA4B/BMPR2/CMTM8/HMGB1/SEMA7A/PDGFD/INSL4/EFNA5	22
GO:0008227	G protein-coupled amine receptor activity	1/1123	51/18367	0.960132213634146	0.985749401831428	ADRB1	1
GO:0016779	nucleotidyltransferase activity	4/1123	132/18367	0.964282991874843	0.988385698812257	PTGES3/CDS1/POLR2J3/REV3L	4
GO:0005244	voltage-gated ion channel activity	7/1123	201/18367	0.965951816108353	0.988385698812257	ITGAV/ANO6/TMEM37/VDAC1/CLCN3/CLIC3/PKD2	7
GO:0022832	voltage-gated channel activity	7/1123	201/18367	0.965951816108353	0.988385698812257	ITGAV/ANO6/TMEM37/VDAC1/CLCN3/CLIC3/PKD2	7
GO:0008408	3'-5' exonuclease activity	1/1123	54/18367	0.967025322201214	0.988385698812257	CNOT6L	1
GO:0000149	SNARE binding	3/1123	110/18367	0.967837139585391	0.988385698812257	ABCA1/SLC6A4/SYT7	3
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	12/1123	310/18367	0.96962647094555	0.989162953393021	PEG3/NFE2L3/ZFHX3/NR3C1/ENO1/LRRFIP1/PURB/FOXP1/SREBF2/NFATC3/REST/IRX2	12
GO:0001217	DNA-binding transcription repressor activity	12/1123	313/18367	0.972297790427665	0.990837366940057	PEG3/NFE2L3/ZFHX3/NR3C1/ENO1/LRRFIP1/PURB/FOXP1/SREBF2/NFATC3/REST/IRX2	12
GO:0005261	cation channel activity	13/1123	335/18367	0.973461510613966	0.990973516625011	ITGAV/ANO6/P2RX4/ITPR2/MCOLN3/SEC61A1/KCNN4/TMEM37/TRPM7/TRPV4/PKD2/ANXA2/TMEM63A	13
GO:0022824	transmitter-gated ion channel activity	1/1123	60/18367	0.977444336627762	0.992926559488814	GABRE	1
GO:0022835	transmitter-gated channel activity	1/1123	60/18367	0.977444336627762	0.992926559488814	GABRE	1
GO:0008528	G protein-coupled peptide receptor activity	4/1123	147/18367	0.981634853118828	0.99613157035898	LGR5/LGR4/S1PR2/EDNRB	4
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/1123	125/18367	0.984457476853539	0.997943195714547	ASAH1/MIER1/CAT	3
GO:0001653	peptide receptor activity	4/1123	153/18367	0.986027401985389	0.998482484957835	LGR5/LGR4/S1PR2/EDNRB	4
GO:0015079	potassium ion transmembrane transporter activity	4/1123	155/18367	0.987255102392119	0.998674456888768	SLC9A1/KCNN4/ATP1A1/PKD2	4
GO:0048018	receptor ligand activity	19/1123	487/18367	0.988758436426852	0.999144554456546	FBN1/CSH1/GRN/EFEMP1/SEMA6D/SEMA6A/MIF/DPP4/SEMA3F/FAM3B/BMP7/COPA/JAG1/SEMA4B/CMTM8/HMGB1/SEMA7A/PDGFD/INSL4	19
GO:0020037	heme binding	3/1123	139/18367	0.992279022967088	0.999754696801047	CYP20A1/CAT/CYCS	3
GO:0030594	neurotransmitter receptor activity	2/1123	111/18367	0.992639386120474	0.999754696801047	ADRB1/GABRE	2
GO:0140098	catalytic activity, acting on RNA	13/1123	386/18367	0.994880005790999	0.999754696801047	DICER1/DDX17/IARS2/POLR2J3/CNOT6L/XRN1/RNMT/DHX36/DCP2/AGO2/MOV10/TARBP1/SND1	13
GO:0005267	potassium channel activity	2/1123	121/18367	0.99578837057446	0.999754696801047	KCNN4/PKD2	2
GO:0140101	catalytic activity, acting on a tRNA	2/1123	124/18367	0.996441978351559	0.999754696801047	IARS2/TARBP1	2
GO:0005249	voltage-gated potassium channel activity	1/1123	90/18367	0.996628734636853	0.999754696801047	PKD2	1
GO:0005125	cytokine activity	6/1123	235/18367	0.996636958661334	0.999754696801047	GRN/MIF/FAM3B/BMP7/CMTM8/HMGB1	6
GO:0004497	monooxygenase activity	1/1123	102/18367	0.998425233554915	0.999760077594151	CYP20A1	1
GO:0022843	voltage-gated cation channel activity	2/1123	143/18367	0.998790321950895	0.999760077594151	ITGAV/PKD2	2
GO:0003823	antigen binding	2/1123	171/18367	0.999760077594151	0.999760077594151	DHCR24/TAPBP	2