ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0002181 cytoplasmic translation 46/1115 148/18722 2.44872607226728e-21 1.3073748499835e-17 RPL23A/RPL3/RPL27A/RPL13A/RPL15/RPS3A/RPS10/RPL9/RPL6/RPLP0/RPL31/RPS20/RPS11/RPL7/RPL23/RPL36A/RPS6/RPL5/RPS2/RPS8/RPS16/RPL7A/RPL14/RPL39/RPS3/RPS17/RPL17/RPS4X/RPL26/RPL24/RPS21/RPS25/RPS13/RPSA/RPL10A/RPL38/EIF3A/CPEB4/RPS9/DHX36/RPL35/RPL27/EIF2S2/EIF3H/RPL4/YBX3 46 GO:0042060 wound healing 61/1115 422/18722 1.06317796103017e-10 2.83815356697005e-07 EGFR/F5/DAG1/IL6ST/ITGB1/ANXA5/ANXA1/KANK1/LMAN1/FBLN1/MACF1/ACTG1/DST/PLPP3/NF1/PPIA/GJA1/TFPI/ANO6/ERBB3/PLEC/GNAQ/MYL12A/B4GALT1/GNA12/ARFGEF1/SYT7/FN1/TGFBR1/JMJD1C/FERMT1/SMPD1/ADAM17/GLI3/F11R/MIA3/HSPB1/DDR1/DSP/VAV3/CLDN4/SMAD2/C1QTNF1/AK3/HMGB1/FZD6/MAPK14/TSKU/CFLAR/HPS5/CAV1/MYOF/ACTB/PPP3CA/ITGB6/FGFR2/ANXA2/OCLN/PTK7/ERBB2/RHOA 61 GO:0001667 ameboidal-type cell migration 64/1115 475/18722 7.18289567854002e-10 1.27831600092417e-06 LAMA5/MET/ITGB1/NRP2/ITGB4/GRN/ANXA1/SEMA6D/FSTL1/KANK1/PFN1/LRP5/NRP1/SEMA6A/LGMN/S100P/MACF1/ATP2B4/RTN4/DPP4/PLPP3/NF1/SEMA3F/GJA1/SERPINF1/PLEC/BMP7/P2RX4/PKN2/GNA12/FOLR1/FN1/ROCK1/TGFBR1/SEMA4B/EPHB4/FERMT1/NR2F2/TPBG/AMOT/ADAM17/PTPRM/BMPR2/TMSB4X/MIA3/HSPB1/FOXP1/EMC10/CLN3/AGO2/AKT3/HMGB1/SEMA7A/RAB13/CAPN7/EDNRB/APPL1/ARID5B/PHACTR4/ISL1/SMURF2/GPC3/RHOA/WASF2 64 GO:0010232 vascular transport 23/1115 88/18722 1.1141283601343e-09 1.48708282868926e-06 LRP2/LRP1/SLC2A1/ATP2B4/SLC19A1/SLC38A2/SLC5A3/GJA1/SLC16A12/SLC1A5/SLC5A6/SLC28A2/SLC22A5/SLC16A1/TFRC/SLC38A1/SLC7A2/SLC1A3/SLC44A1/SLC13A3/SLC29A1/SLC16A2/INSR 23 GO:0001655 urogenital system development 50/1115 338/18722 2.36659842999942e-09 2.52705380355338e-06 FBN1/LRP2/LAMA5/ADAMTS6/LGR5/MME/ANXA1/PSAP/LGR4/IQGAP1/NRP1/PBX1/NIPBL/COL4A1/C1GALT1/NF1/SERPINF1/ENPEP/MAGED1/BMP7/DLG5/DLG1/SEC61A1/JAG1/ADAMTS1/TGFBR1/SMARCC1/MTSS1/GCNT4/GLI3/SMAD2/FRAS1/RRM2B/PDGFD/AHI1/CFLAR/FEM1B/ARID5B/PKD2/FGFR2/CAT/FREM2/PTK7/PLAG1/GPC3/CTNNB1/WFS1/IRX2/RHOA/HPGD 50 GO:0060070 canonical Wnt signaling pathway 46/1115 303/18722 4.50465754187142e-09 3.81987614282077e-06 EGFR/LGR5/KANK1/LRP5/LGR4/WLS/PLPP3/ZNRF3/TBL1X/CTNND1/USP47/GNAQ/UBR5/FOLR1/RYK/TCF7L2/FZD5/FERMT1/USP34/TNKS2/TPBG/DVL3/AMFR/SCYL2/RBPJ/SIAH2/LATS2/TBL1XR1/RBMS3/WNK1/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/CAV1/CSNK1A1/XIAP/FGFR2/ISL1/FZD3/SMURF2/PTK7/GPC3/CTNNB1 46 GO:0150104 transport across blood-brain barrier 22/1115 87/18722 5.00826615466293e-09 3.81987614282077e-06 LRP2/LRP1/SLC2A1/ATP2B4/SLC19A1/SLC38A2/SLC5A3/SLC16A12/SLC1A5/SLC5A6/SLC28A2/SLC22A5/SLC16A1/TFRC/SLC38A1/SLC7A2/SLC1A3/SLC44A1/SLC13A3/SLC29A1/SLC16A2/INSR 22 GO:0072001 renal system development 45/1115 302/18722 1.19038860311061e-08 7.94435594000944e-06 FBN1/LRP2/LAMA5/ADAMTS6/LGR5/MME/LGR4/IQGAP1/NRP1/PBX1/NIPBL/COL4A1/C1GALT1/NF1/SERPINF1/ENPEP/MAGED1/BMP7/DLG5/DLG1/SEC61A1/JAG1/ADAMTS1/TGFBR1/MTSS1/GCNT4/GLI3/SMAD2/FRAS1/RRM2B/PDGFD/AHI1/CFLAR/ARID5B/PKD2/FGFR2/CAT/FREM2/PTK7/GPC3/CTNNB1/WFS1/IRX2/RHOA/HPGD 45 GO:0048608 reproductive structure development 56/1115 424/18722 1.72251466252685e-08 1.02183397591454e-05 LRP2/SPINT1/KRT19/ADGRG1/KRT8/MME/ANXA1/PSAP/LGR4/ITGB8/RPS6/NIPBL/ASH1L/ZFP36L1/ATRX/GJA1/SERPINF1/CTSB/HECTD1/BMP7/BPTF/SF1/PRDX4/HSP90AB1/BIRC6/ST14/DLG1/ADAMTS1/TGFBR1/FZD5/HSPA5/KDM5A/NR2F2/SMARCC1/RHOBTB3/RBPJ/GLI3/BMPR2/ZFX/DHCR24/SETD2/MAPK14/RAB13/CCND1/FEM1B/ARID5B/PKD2/TLR3/FGFR2/IDH1/EIF2S2/PLAG1/CTNNB1/PRDX3/SOD1/YBX3 56 GO:0071559 response to transforming growth factor beta 40/1115 256/18722 2.01418088090835e-08 1.07266568091098e-05 FBN1/FBN2/COL4A2/GLG1/ITGB8/ITGB5/ZFP36L1/TGFBR3/ZFHX3/LTBP1/GCNT2/NR3C1/FURIN/HSP90AB1/FOLR1/ZNF451/USP9X/LTBP3/ROCK1/TGFBR1/HSPA5/FERMT1/CHST11/TRIM33/LATS2/ADAM17/SMAD2/PTPRK/PDGFD/CFLAR/CAV1/APPL1/BMPR1A/ITGB6/FGFR2/SMURF2/CREBBP/HSPA1A/HPGD/CDKN1C 40 GO:0061458 reproductive system development 56/1115 427/18722 2.21002481551242e-08 1.07266568091098e-05 LRP2/SPINT1/KRT19/ADGRG1/KRT8/MME/ANXA1/PSAP/LGR4/ITGB8/RPS6/NIPBL/ASH1L/ZFP36L1/ATRX/GJA1/SERPINF1/CTSB/HECTD1/BMP7/BPTF/SF1/PRDX4/HSP90AB1/BIRC6/ST14/DLG1/ADAMTS1/TGFBR1/FZD5/HSPA5/KDM5A/NR2F2/SMARCC1/RHOBTB3/RBPJ/GLI3/BMPR2/ZFX/DHCR24/SETD2/MAPK14/RAB13/CCND1/FEM1B/ARID5B/PKD2/TLR3/FGFR2/IDH1/EIF2S2/PLAG1/CTNNB1/PRDX3/SOD1/YBX3 56 GO:0032970 regulation of actin filament-based process 53/1115 396/18722 2.6626049807323e-08 1.18463733267748e-05 AKAP9/LRP1/MET/KANK1/PFN1/DSC2/IQGAP2/IQGAP1/NRP1/ACTG1/SCIN/DSG2/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/TAOK1/SLC9A1/DLG1/ATP2A2/ARHGAP18/AKAP13/SPTAN1/ARHGAP28/ROCK1/CD47/TGFBR1/RICTOR/NCKAP1/GJA5/PPP1R9A/MTSS1/C9orf72/KANK4/RHOBTB3/PPFIA1/ATP1A1/S100A10/F11R/TMSB4X/WASL/DSP/ARPC3/RHOBTB1/PKP2/CAV1/EFNA5/ABI2/CYFIP2/RHOA/WASF2/DSTN 53 GO:0016055 Wnt signaling pathway 57/1115 444/18722 3.53164480591252e-08 1.43851893334139e-05 EGFR/LRP1/LGR5/KANK1/LRP5/LGR4/WLS/RNF43/MACF1/APP/PLPP3/ZNRF3/TBL1X/DAAM1/CTNND1/USP47/GNAQ/UBR5/DDB1/FOLR1/RYK/TCF7L2/FZD5/FERMT1/USP34/TNKS2/TPBG/DVL3/AMFR/SCYL2/RBPJ/SIAH2/LATS2/TBL1XR1/RBMS3/WNK1/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/TSKU/CAV1/CCND1/CSNK1A1/XIAP/RNF213/PKD2/FGFR2/ISL1/FZD3/SMURF2/PTK7/GPC3/CTNNB1/RHOA 57 GO:0001822 kidney development 43/1115 293/18722 3.93675958915293e-08 1.43851893334139e-05 FBN1/LRP2/LAMA5/ADAMTS6/MME/LGR4/IQGAP1/NRP1/PBX1/NIPBL/C1GALT1/NF1/SERPINF1/ENPEP/MAGED1/BMP7/DLG5/DLG1/SEC61A1/JAG1/ADAMTS1/TGFBR1/MTSS1/GCNT4/GLI3/SMAD2/FRAS1/RRM2B/PDGFD/AHI1/CFLAR/ARID5B/PKD2/FGFR2/CAT/FREM2/PTK7/GPC3/CTNNB1/WFS1/IRX2/RHOA/HPGD 43 GO:0198738 cell-cell signaling by wnt 57/1115 446/18722 4.13645896171787e-08 1.43851893334139e-05 EGFR/LRP1/LGR5/KANK1/LRP5/LGR4/WLS/RNF43/MACF1/APP/PLPP3/ZNRF3/TBL1X/DAAM1/CTNND1/USP47/GNAQ/UBR5/DDB1/FOLR1/RYK/TCF7L2/FZD5/FERMT1/USP34/TNKS2/TPBG/DVL3/AMFR/SCYL2/RBPJ/SIAH2/LATS2/TBL1XR1/RBMS3/WNK1/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/TSKU/CAV1/CCND1/CSNK1A1/XIAP/RNF213/PKD2/FGFR2/ISL1/FZD3/SMURF2/PTK7/GPC3/CTNNB1/RHOA 57 GO:0060828 regulation of canonical Wnt signaling pathway 39/1115 253/18722 4.39955992059207e-08 1.43851893334139e-05 EGFR/LGR5/KANK1/LGR4/WLS/ZNRF3/TBL1X/CTNND1/USP47/GNAQ/UBR5/FOLR1/TCF7L2/FERMT1/USP34/TNKS2/TPBG/AMFR/SCYL2/RBPJ/SIAH2/LATS2/TBL1XR1/RBMS3/WNK1/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/CAV1/CSNK1A1/XIAP/FGFR2/ISL1/SMURF2/PTK7/GPC3 39 GO:0048732 gland development 56/1115 436/18722 4.58041241183809e-08 1.43851893334139e-05 EGFR/LAMA5/DAG1/CDH1/MET/ANXA1/LRP5/PSAP/WLS/NRP1/PBX1/PRLR/ARHGAP5/RTN4/RPS16/ASH1L/NF1/TGFBR3/PRKDC/SERPINF1/BMP7/KRT18/IGSF3/PLXNA1/RB1CC1/MAN2A1/SEC63/TGFBR1/SMARCC1/JARID2/RBPJ/SLC29A1/NFIB/GLI3/BTBD7/DDR1/SMAD2/LY6E/TFCP2L1/COBL/CFLAR/CAV1/CCND1/ZDHHC21/FEM1B/ARID5B/BMPR1A/PKD2/FGFR2/ISL1/PLAG1/CTNNB1/FASN/GPAT4/HNRNPD/SOD1 56 GO:0009101 glycoprotein biosynthetic process 45/1115 317/18722 5.25870808830112e-08 1.44933165757437e-05 GALNT11/CHPF/EXTL2/RPN2/GXYLT1/HS6ST2/C1GALT1/EDEM3/GCNT2/STT3B/B4GALT1/TRIP11/MOGS/MAN2A1/ARFGEF1/DSE/TET2/B4GALT5/MAN1A2/B3GNT2/TUSC3/ITM2B/TCF7L2/B3GNT5/NPC1/CHST11/STT3A/NCSTN/GCNT4/B3GNT3/BMPR2/RPN1/MAN1C1/CHST14/AGO2/CANT1/TMTC3/TRAK2/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1/CTNNB1/MAN1B1 45 GO:0032535 regulation of cellular component size 51/1115 382/18722 5.28304712748433e-08 1.44933165757437e-05 LRP1/SEMA6D/KANK1/PFN1/IQGAP2/GOLGA4/NRP1/NPM1/SEMA6A/MACF1/RTN4/SCIN/SEMA3F/ANO6/NRCAM/SPTBN1/CDKL5/HSP90AB1/MYO1C/RASA1/ADD3/RB1CC1/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/FN1/KCNN4/RYK/SEMA4B/RICTOR/NCKAP1/PPP1R9A/CLCN3/KANK4/TRPV4/BMPR2/TMSB4X/WASL/VAV3/ARPC3/CLN3/AKT3/SEMA7A/ABI2/TMEM123/CYFIP2/RHOA/WASF2/DSTN 51 GO:0030111 regulation of Wnt signaling pathway 46/1115 328/18722 5.42922516416696e-08 1.44933165757437e-05 EGFR/LRP1/LGR5/KANK1/LGR4/WLS/RNF43/MACF1/APP/PLPP3/ZNRF3/TBL1X/CTNND1/USP47/GNAQ/UBR5/FOLR1/TCF7L2/FERMT1/USP34/TNKS2/TPBG/AMFR/SCYL2/RBPJ/SIAH2/LATS2/TBL1XR1/RBMS3/WNK1/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/TSKU/CAV1/CSNK1A1/XIAP/RNF213/FGFR2/ISL1/SMURF2/PTK7/GPC3 46 GO:0009100 glycoprotein metabolic process 51/1115 387/18722 8.0503773224518e-08 2.0467125964081e-05 GALNT11/CHPF/EXTL2/GANAB/RPN2/GXYLT1/HS6ST2/C1GALT1/EDEM3/GCNT2/STT3B/MANBA/B4GALT1/TRIP11/MOGS/MAN2A1/ARFGEF1/DSE/TET2/GPC1/B4GALT5/MAN1A2/B3GNT2/TUSC3/GNPTAB/ITM2B/TCF7L2/B3GNT5/NPC1/CHST11/STT3A/NCSTN/AMFR/GCNT4/B3GNT3/BMPR2/RPN1/MAN1C1/CHST14/AGO2/CANT1/TMTC3/TRAK2/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1/TRIM13/CTNNB1/MAN1B1 51 GO:0071560 cellular response to transforming growth factor beta stimulus 38/1115 250/18722 9.52654575598108e-08 2.31191944505377e-05 FBN1/FBN2/COL4A2/GLG1/ITGB8/ITGB5/ZFP36L1/TGFBR3/LTBP1/GCNT2/NR3C1/FURIN/HSP90AB1/FOLR1/ZNF451/USP9X/LTBP3/TGFBR1/HSPA5/FERMT1/CHST11/TRIM33/LATS2/ADAM17/SMAD2/PTPRK/PDGFD/CFLAR/CAV1/APPL1/BMPR1A/ITGB6/FGFR2/SMURF2/CREBBP/HSPA1A/HPGD/CDKN1C 38 GO:0051701 biological process involved in interaction with host 33/1115 203/18722 1.33392065242185e-07 3.09643581012185e-05 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/SLC52A1/ITGB5/DPP4/CD74/PPIA/ANO6/CTSB/SLC1A5/SCARB2/DDB1/TFRC/P4HB/RPSA/WWP1/THOC2/NPC1/SMPD1/F11R/LY6E/SLC52A2/CAV1/INSR/ITGB6/TRIM38/SERPINB9/TRIM13/HSPA1A 33 GO:0048863 stem cell differentiation 33/1115 206/18722 1.89987903023743e-07 4.22643922601568e-05 LAMA5/NRP2/SEMA6D/N4BP2L2/NRP1/SEMA6A/MSI2/SEMA3F/PRKDC/BMP7/KRT18/FOLR1/FN1/LTBP3/JAG1/UFL1/SEMA4B/JARID2/RBPJ/DHX36/SETD2/PUM1/SEMA7A/EDNRB/PHACTR4/CDK12/BMPR1A/REST/FGFR2/ISL1/CDK13/FOXO4/CTNNB1 33 GO:0061564 axon development 57/1115 467/18722 2.01407410935678e-07 4.30125666794234e-05 LAMA5/LRP1/DAG1/ITGB1/NRP2/GRN/SEMA6D/PTPRF/GOLGA4/NRP1/MYCBP2/SEMA6A/MACF1/APP/RTN4/PLXNB1/SEMA3F/ANK3/NRCAM/BMP7/CDKL5/HSP90AB1/PLXNB2/RPS6KA5/PLXNA1/RPL24/FOLR1/B4GALT5/FN1/USP9X/B3GNT2/PALLD/RYK/NOTCH3/SEMA4B/EPHB4/KIF5B/TOP2B/C9orf72/MTR/PTPRM/NFIB/GLI3/BMPR2/DDR1/COBL/SEMA7A/ZDHHC17/CAMSAP2/TSKU/TRAK2/ACTB/EFNA5/FGFR2/ISL1/FZD3/ERBB2 57 GO:0007179 transforming growth factor beta receptor signaling pathway 32/1115 198/18722 2.36017965442484e-07 4.78670242718975e-05 FBN1/FBN2/GLG1/ITGB8/ITGB5/TGFBR3/LTBP1/GCNT2/FURIN/HSP90AB1/FOLR1/ZNF451/USP9X/LTBP3/TGFBR1/HSPA5/FERMT1/CHST11/TRIM33/LATS2/ADAM17/SMAD2/PTPRK/CAV1/APPL1/BMPR1A/ITGB6/SMURF2/CREBBP/HSPA1A/HPGD/CDKN1C 32 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 52/1115 412/18722 2.42069611414353e-07 4.78670242718975e-05 CANX/HSP90B1/EDEM3/TBL1X/HECTD1/KLHL42/STT3B/DNAJB14/HSP90AB1/SEL1L/NHLRC3/ERLEC1/GNA12/DDB1/PCBP2/RNF217/NEMF/UFL1/UBXN4/HSPA5/WWP1/ZYG11B/SMARCC1/AMFR/SKP2/LTN1/SIAH2/TBL1XR1/PIAS1/CCDC47/UBE4A/RNF19A/JKAMP/CAV1/DDA1/FBXL5/FEM1B/CSNK1A1/UBE2H/UBE4B/SKP1/UBR3/SMURF2/TRIM13/UBE2C/EIF3H/CTNNB1/MAN1B1/CDC20/HSPA1A/WFS1/PSMB5 52 GO:0036363 transforming growth factor beta activation 7/1115 10/18722 2.67106921557547e-07 5.09315662212765e-05 ITGAV/ITGB8/LTBP1/FURIN/HSP90AB1/LTBP3/ITGB6 7 GO:0016032 viral process 52/1115 415/18722 3.04390135463432e-07 5.60392735599746e-05 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/HACD3/CANX/SLC52A1/ITGB5/CFL1/DPP4/CD74/PPIA/ANO6/EEA1/CTSB/SLC1A5/FURIN/HSP90AB1/PKN2/MOGS/MAN2A1/SCARB2/DDB1/PCBP2/TFRC/SPCS3/P4HB/RPSA/RSF1/WWP1/MPHOSPH8/NPC1/TOP2B/SMPD1/EIF3A/F11R/LY6E/SLC52A2/CAV1/RAN/STOM/INSR/ITGB6/REST/TRIM38/MAVS/MGAT1/TRIM13/MAN1B1/HSPA1A 52 GO:0001890 placenta development 26/1115 144/18722 3.51527971389086e-07 6.00993938753277e-05 SPINT1/KRT19/KRT8/MME/ITGB8/RPS6/ASH1L/ZFP36L1/GJA1/CTSB/HECTD1/BMP7/BPTF/HSP90AB1/BIRC6/ST14/FZD5/NR2F2/RBPJ/BMPR2/SETD2/MAPK14/PKD2/FGFR2/PRDX3/SOD1 26 GO:0046718 viral entry into host cell 26/1115 144/18722 3.51527971389086e-07 6.00993938753277e-05 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/SLC52A1/ITGB5/DPP4/CD74/CTSB/SLC1A5/SCARB2/TFRC/P4HB/RPSA/WWP1/NPC1/SMPD1/F11R/LY6E/SLC52A2/CAV1/ITGB6/TRIM38/HSPA1A 26 GO:0003018 vascular process in circulatory system 38/1115 263/18722 3.60213636263436e-07 6.00993938753277e-05 EGFR/LRP2/LRP1/ATP2B1/SLC2A1/SLC6A4/ADRB1/ATP2B4/SLC19A1/SLC38A2/SLC5A3/GJA1/SLC16A12/PLEC/SLC1A5/SLC5A6/SLC28A2/ROCK1/SLC22A5/SLC16A1/TFRC/SLC38A1/SLC7A2/SLC1A3/GJA5/SLC44A1/SLC13A3/SLC29A1/TRPV4/BMPR2/CAV1/ZDHHC21/SLC16A2/EDNRB/INSR/OCLN/RHOA/SOD1 38 GO:0010498 proteasomal protein catabolic process 58/1115 490/18722 4.44139525488569e-07 7.18563917146506e-05 CANX/HSP90B1/EDEM3/TBL1X/HECTD1/KLHL42/STT3B/DNAJB14/HSP90AB1/SEL1L/USP25/NHLRC3/ERLEC1/GNA12/DDB1/PCBP2/RNF217/NEMF/UFL1/UBXN4/HSPA5/WWP1/ZYG11B/SMARCC1/AMFR/TMEM259/SKP2/LTN1/SIAH2/TBL1XR1/DDI2/PIAS1/CCDC47/UBE4A/RNF19A/TMTC3/JKAMP/CAV1/DDA1/FBXL5/FEM1B/CSNK1A1/HM13/UBE2H/UBE4B/SKP1/UBR3/SMURF2/TRIM13/UBE2C/EIF3H/CTNNB1/MAN1B1/RHBDF1/CDC20/HSPA1A/WFS1/PSMB5 58 GO:0022604 regulation of cell morphogenesis 42/1115 309/18722 4.84518115064569e-07 7.53111633768097e-05 DAG1/ANXA1/KANK1/NRP1/FBLN1/MACF1/CFL1/PLXNB1/ALDOA/BRWD1/PRKDC/CUX1/HEXB/MYL12B/CDKL5/PLXNB2/RASA1/PLXNA1/MYL12A/DLG1/ACTN4/ARHGAP18/FN1/LARP4/PHIP/FMNL2/P4HB/DVL3/RHOBTB3/S100A10/F11R/MYH10/DHX36/CLDN4/RHOBTB1/OBSL1/ITSN2/EFNA5/MKLN1/MOV10/RHOA/CDC42SE1 42 GO:0052126 movement in host environment 29/1115 175/18722 5.01474697166943e-07 7.53111633768097e-05 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/SLC52A1/ITGB5/DPP4/CD74/PPIA/CTSB/SLC1A5/SCARB2/DDB1/TFRC/P4HB/RPSA/WWP1/NPC1/SMPD1/F11R/LY6E/SLC52A2/CAV1/ITGB6/TRIM38/TRIM13/HSPA1A 29 GO:0034976 response to endoplasmic reticulum stress 37/1115 256/18722 5.07810803814413e-07 7.53111633768097e-05 CANX/HSP90B1/EDEM3/STT3B/DNAJB14/SEL1L/USP25/ATF6/ERLEC1/ATP2A2/GRINA/CREB3L2/SERINC3/UFL1/UBXN4/P4HB/HSPA5/PDIA3/AMFR/TMEM259/TMEM33/DNAJC3/CCDC47/PDIA4/UBE4A/TMTC3/JKAMP/CAV1/CCND1/PPP1R15B/HM13/LPCAT3/UBE4B/TRIM13/MAN1B1/HSPA1A/WFS1 37 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 46/1115 355/18722 5.64254482898801e-07 8.14203968701811e-05 FBN1/FBN2/LRP2/CRIM1/LRP1/FSTL1/GLG1/ITGB8/ITGB5/TGFBR3/LTBP1/GCNT2/SPTBN1/BMP7/FURIN/HSP90AB1/FOLR1/ZNF451/USP9X/LTBP3/TGFBR1/HSPA5/FERMT1/CHST11/TRIM33/NCEH1/RBPJ/LATS2/ADAM17/BMPR2/SMAD2/PTPRK/MAPK14/CAV1/APPL1/XIAP/BMPR1A/ITGB6/SMURF2/CREBBP/GPC3/SUB1/ACVR2B/HSPA1A/HPGD/CDKN1C 46 GO:0043484 regulation of RNA splicing 26/1115 148/18722 6.10658227205964e-07 8.57974809224379e-05 AHNAK/HNRNPA1/SON/NPM1/MBNL3/MBNL2/SLC38A2/RBM25/DDX17/SF1/RBM5/SRSF3/MBNL1/HNRNPH1/RPS13/PTBP3/CELF1/ESRP1/CDK12/TRA2B/REST/NCL/HSPA1A/SAP18/FUS/SRSF9 26 GO:0034975 protein folding in endoplasmic reticulum 7/1115 11/18722 6.96586742918816e-07 9.53609389857322e-05 CANX/HSP90B1/P4HB/HSPA5/PDIA3/DNAJC3/ERO1B 7 GO:0007015 actin filament organization 53/1115 441/18722 8.71679029929106e-07 0.000115707046494658 MET/KANK1/PFN1/IQGAP2/NRP1/HSP90B1/ITGB5/ACTG1/DIAPH2/CFL1/SCIN/ALDOA/PLEC/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/SLC9A1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/ROCK1/CD47/TGFBR1/TTC17/RICTOR/FAT1/NCKAP1/PRKCI/PPP1R9A/MTSS1/C9orf72/KANK4/RHOBTB3/SORBS1/PPFIA1/S100A10/TRPV4/F11R/TMSB4X/WASL/MYO7A/ARPC3/COBL/RHOBTB1/MYO6/ABI2/CYFIP2/RHOA/WASF2/DSTN 53 GO:0007409 axonogenesis 51/1115 418/18722 8.90340710441443e-07 0.000115707046494658 LAMA5/LRP1/DAG1/ITGB1/NRP2/SEMA6D/GOLGA4/NRP1/MYCBP2/SEMA6A/MACF1/APP/RTN4/PLXNB1/SEMA3F/ANK3/NRCAM/BMP7/CDKL5/HSP90AB1/PLXNB2/RPS6KA5/PLXNA1/RPL24/B4GALT5/FN1/USP9X/B3GNT2/PALLD/RYK/NOTCH3/SEMA4B/EPHB4/KIF5B/TOP2B/C9orf72/PTPRM/NFIB/GLI3/BMPR2/COBL/SEMA7A/ZDHHC17/TSKU/TRAK2/ACTB/EFNA5/FGFR2/ISL1/FZD3/ERBB2 51 GO:0044409 entry into host 26/1115 151/18722 9.10225876152021e-07 0.000115707046494658 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/SLC52A1/ITGB5/DPP4/CD74/CTSB/SLC1A5/SCARB2/TFRC/P4HB/RPSA/WWP1/NPC1/SMPD1/F11R/LY6E/SLC52A2/CAV1/ITGB6/TRIM38/HSPA1A 26 GO:0036503 ERAD pathway 21/1115 107/18722 1.1335056077077e-06 0.000139619186621831 CANX/HSP90B1/EDEM3/STT3B/DNAJB14/SEL1L/USP25/ERLEC1/UBXN4/HSPA5/AMFR/TMEM259/CCDC47/UBE4A/JKAMP/CAV1/HM13/UBE4B/TRIM13/MAN1B1/WFS1 21 GO:0010975 regulation of neuron projection development 53/1115 445/18722 1.15063573915725e-06 0.000139619186621831 ITGA6/TENM3/LRP1/GRN/SEMA6D/PTPRF/KANK1/GOLGA4/IQGAP1/NRP1/SEMA6A/MACF1/RTN4/CFL1/PLXNB1/SEMA3F/SERPINF1/CUX1/TMEM30A/BMP7/CDKL5/PLXNB2/ADAM10/P3H1/PLXNA1/VLDLR/SCARB2/KIDINS220/FN1/CREB3L2/RYK/TMEM106B/SEMA4B/HSPA5/THOC2/PRKCI/PPP1R9A/TRPV4/BMPR2/DHX36/COBL/SEMA7A/CAMSAP2/TSKU/CFLAR/TRAK2/OBSL1/PPP3CA/ABI2/PTK7/RAPGEF2/CDC20/RHOA 53 GO:0044403 biological process involved in symbiotic interaction 39/1115 290/18722 1.61045963624639e-06 0.00018684046040685 EGFR/GAPDH/DAG1/CD46/ITGB1/ITGAV/NRP1/SLC52A1/ITGB5/CFL1/DPP4/CD74/PPIA/ANO6/CTSB/SLC1A5/HSP90AB1/SCARB2/DDB1/FN1/TFRC/P4HB/RPSA/WWP1/THOC2/NPC1/SMPD1/F11R/LY6E/SLC52A2/CAV1/STOM/INSR/ITGB6/REST/TRIM38/SERPINB9/TRIM13/HSPA1A 39 GO:0006486 protein glycosylation 33/1115 226/18722 1.64478397436261e-06 0.00018684046040685 GALNT11/EXTL2/RPN2/GXYLT1/C1GALT1/EDEM3/GCNT2/STT3B/B4GALT1/TRIP11/MOGS/MAN2A1/ARFGEF1/TET2/B4GALT5/MAN1A2/B3GNT2/TUSC3/B3GNT5/NPC1/STT3A/GCNT4/B3GNT3/RPN1/MAN1C1/TMTC3/TRAK2/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1/MAN1B1 33 GO:0043413 macromolecule glycosylation 33/1115 226/18722 1.64478397436261e-06 0.00018684046040685 GALNT11/EXTL2/RPN2/GXYLT1/C1GALT1/EDEM3/GCNT2/STT3B/B4GALT1/TRIP11/MOGS/MAN2A1/ARFGEF1/TET2/B4GALT5/MAN1A2/B3GNT2/TUSC3/B3GNT5/NPC1/STT3A/GCNT4/B3GNT3/RPN1/MAN1C1/TMTC3/TRAK2/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1/MAN1B1 33 GO:0098901 regulation of cardiac muscle cell action potential 10/1115 27/18722 1.79036450523481e-06 0.000197969553260889 AKAP9/DSC2/CALM1/DSG2/DLG1/ATP2A2/GJA5/DSP/PKP2/CAV1 10 GO:0007411 axon guidance 33/1115 227/18722 1.81691479861089e-06 0.000197969553260889 LAMA5/LRP1/DAG1/NRP2/SEMA6D/NRP1/MYCBP2/SEMA6A/APP/PLXNB1/SEMA3F/NRCAM/BMP7/PLXNB2/RPS6KA5/PLXNA1/RPL24/B3GNT2/PALLD/RYK/NOTCH3/SEMA4B/EPHB4/KIF5B/PTPRM/NFIB/GLI3/BMPR2/SEMA7A/EFNA5/ISL1/FZD3/ERBB2 33 GO:1902903 regulation of supramolecular fiber organization 47/1115 382/18722 1.87818021732655e-06 0.000200552083606129 AKAP9/MET/KANK1/PFN1/IQGAP2/NRP1/CLIP1/APP/ACTG1/SCIN/RPS3/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/TAOK1/SLC9A1/DLG1/ARHGAP18/AKAP13/SPTAN1/ARHGAP28/ROCK1/CD47/TGFBR1/RICTOR/NCKAP1/PPP1R9A/MTSS1/C9orf72/KANK4/PPFIA1/S100A10/TRPV4/F11R/TMSB4X/WASL/ARPC3/CAMSAP2/ABI2/CYFIP2/OCLN/HSPA1A/RHOA/WASF2/DSTN 47 GO:0097485 neuron projection guidance 33/1115 228/18722 2.00557016289594e-06 0.000209955668621597 LAMA5/LRP1/DAG1/NRP2/SEMA6D/NRP1/MYCBP2/SEMA6A/APP/PLXNB1/SEMA3F/NRCAM/BMP7/PLXNB2/RPS6KA5/PLXNA1/RPL24/B3GNT2/PALLD/RYK/NOTCH3/SEMA4B/EPHB4/KIF5B/PTPRM/NFIB/GLI3/BMPR2/SEMA7A/EFNA5/ISL1/FZD3/ERBB2 33 GO:0030433 ubiquitin-dependent ERAD pathway 18/1115 85/18722 2.07947857556599e-06 0.000213506463748977 CANX/HSP90B1/EDEM3/STT3B/DNAJB14/SEL1L/ERLEC1/UBXN4/HSPA5/AMFR/CCDC47/UBE4A/JKAMP/CAV1/UBE4B/TRIM13/MAN1B1/WFS1 18 GO:0001503 ossification 49/1115 408/18722 2.28913487616661e-06 0.000227957820242266 FBN2/EGFR/SLC26A2/CRIM1/ATP2B1/IL6ST/RRBP1/LRP5/CDK6/LGR4/PBX1/NIPBL/PLXNB1/NF1/ANO6/BMP7/CLTC/ATP6V1B1/ANKH/LTBP3/COL5A2/ATP6AP1/JAG1/UFL1/SUCO/RPL38/KLF10/RBPJ/TMEM64/GLI3/BMPR2/CCDC47/DHX36/SEMA7A/MAPK14/BMPR1A/HNRNPC/REST/FGFR2/DHRS3/CAT/GPC3/ACVR2B/CTNNB1/FASN/ATRAID/SND1/HSPE1/RHOA 49 GO:0070085 glycosylation 34/1115 240/18722 2.30562320529732e-06 0.000227957820242266 GALNT11/EXTL2/RPN2/GXYLT1/C1GALT1/EDEM3/GCNT2/STT3B/B4GALT1/TRIP11/MOGS/MAN2A1/ARFGEF1/TET2/B4GALT5/MAN1A2/B3GNT2/TUSC3/B3GNT5/NPC1/CLN5/STT3A/GCNT4/B3GNT3/RPN1/MAN1C1/TMTC3/TRAK2/ALG2/DPY19L1/ALG10B/B3GAT3/MGAT1/MAN1B1 34 GO:0048864 stem cell development 18/1115 86/18722 2.485249992063e-06 0.000241249994684079 LAMA5/NRP2/SEMA6D/NRP1/SEMA6A/MSI2/SEMA3F/BMP7/FOLR1/FN1/JAG1/SEMA4B/SETD2/SEMA7A/EDNRB/PHACTR4/BMPR1A/ISL1 18 GO:0007044 cell-substrate junction assembly 19/1115 95/18722 2.70519133511072e-06 0.000254002678044311 ITGA6/LAMC1/LRP1/ITGB4/IQGAP1/NRP1/MACF1/ACTG1/DST/PLEC/SLC9A1/FN1/PTPRA/ROCK1/SORBS1/S100A10/PTPRK/EFNA5/RHOA 19 GO:0050767 regulation of neurogenesis 45/1115 364/18722 2.72201700361255e-06 0.000254002678044311 EGFR/LRP2/SPINT1/LRP1/DAG1/IL6ST/MME/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/DICER1/PLXNB1/NF1/SEMA3F/SERPINF1/CUX1/BMP7/CDKL5/PLXNB2/PLXNA1/MAN2A1/FN1/PCM1/UFL1/RYK/SEMA4B/PRTG/PRKCI/GLI3/BMPR2/DHX36/SPEN/SEMA7A/TRAK2/BMPR1A/OBSL1/PPP3CA/REST/FZD3/PLAG1/RAPGEF2/CTNNB1 45 GO:0045216 cell-cell junction organization 30/1115 200/18722 2.75934731720735e-06 0.000254002678044311 SVEP1/CDH1/ACTG1/GJA1/PLEC/DSG2/CTNND1/MYO1C/ADAM10/PKN2/DLG5/DLG1/MPP7/ROCK1/TGFBR1/FZD5/GJA5/PRKCI/MTSS1/TRPV4/F11R/DSP/CLDN4/PKP2/CAV1/RAB13/ACTB/OCLN/CTNNB1/RHOA 30 GO:0001755 neural crest cell migration 14/1115 55/18722 2.83904716054074e-06 0.000256909708307237 LAMA5/NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/BMP7/FOLR1/FN1/SEMA4B/SEMA7A/EDNRB/PHACTR4/ISL1 14 GO:0007029 endoplasmic reticulum organization 18/1115 87/18722 2.96122367177201e-06 0.000263499553059846 LMAN1/RTN4/SEC61A1/EMC1/SEC31A/TRAM1/TMEM170A/TMEM33/REEP5/MIA3/RAB3GAP1/CCDC47/EMC10/RAB3GAP2/LPCAT3/TRAM2/TOR1AIP2/ESYT2 18 GO:0048592 eye morphogenesis 25/1115 151/18722 3.06849949266997e-06 0.00026856916051418 FBN1/FBN2/TENM3/EFEMP1/LRP5/NIPBL/NF1/BMP7/TUG1/MAN2A1/COL5A2/JAG1/FZD5/FAT1/PRKCI/PTPRM/GLI3/MYO7A/NAGLU/AHI1/TSKU/PHACTR4/OBSL1/ABI2/CTNNB1 25 GO:0006457 protein folding 31/1115 212/18722 3.26777973554765e-06 0.000281398000130466 GRN/LMAN1/CANX/HSP90B1/CD74/NKTR/PPIA/PTGES3/PRDX4/DNAJB14/HSP90AB1/P3H1/RANBP2/ATF6/MOGS/P4HB/HSPA5/PPIG/PDIA3/CRTAP/DNAJC3/HSPB1/CCDC47/SIL1/PDIA4/ERO1B/DNAJA1/HSPA1A/WFS1/HSPE1/CCT3 31 GO:0110053 regulation of actin filament organization 37/1115 277/18722 3.47542695977795e-06 0.000294528643464357 MET/KANK1/PFN1/IQGAP2/NRP1/ACTG1/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/SLC9A1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/ROCK1/CD47/TGFBR1/RICTOR/NCKAP1/PPP1R9A/MTSS1/C9orf72/KANK4/PPFIA1/S100A10/F11R/TMSB4X/WASL/ARPC3/ABI2/CYFIP2/RHOA/WASF2/DSTN 37 GO:0032956 regulation of actin cytoskeleton organization 44/1115 357/18722 3.79713054320669e-06 0.000316763749534071 LRP1/MET/KANK1/PFN1/IQGAP2/IQGAP1/NRP1/ACTG1/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/TAOK1/SLC9A1/DLG1/ARHGAP18/AKAP13/SPTAN1/ARHGAP28/ROCK1/CD47/TGFBR1/RICTOR/NCKAP1/PPP1R9A/MTSS1/C9orf72/KANK4/RHOBTB3/PPFIA1/S100A10/F11R/TMSB4X/WASL/ARPC3/RHOBTB1/EFNA5/ABI2/CYFIP2/RHOA/WASF2/DSTN 44 GO:0007229 integrin-mediated signaling pathway 20/1115 107/18722 4.46084082358444e-06 0.000366406602417189 ITGA6/LAMA5/ITGB1/ITGB4/ITGAV/NRP1/ITGB8/ITGB5/DST/PLPP3/ADAM10/FN1/PTPRA/ADAMTS1/CD47/FERMT1/VAV3/SEMA7A/PHACTR4/ITGB6 20 GO:1905475 regulation of protein localization to membrane 27/1115 175/18722 5.00546811439701e-06 0.000404912034284328 EGFR/LRP1/DAG1/TCAF1/ITGB1/ATP2B4/SLC5A3/ANK3/HECTD1/SPTBN1/CLTC/MYO1C/ADAM10/DLG1/GPC1/KIF5B/PRKCI/LYPLA1/SORBS1/PPFIA1/CLN3/ACSL3/APPL1/STOM/ACTB/GPC3/ERBB2 27 GO:0071604 transforming growth factor beta production 12/1115 43/18722 5.14019521587514e-06 0.00040643297806198 CD46/ITGAV/ITGB8/LTBP1/FURIN/HSP90AB1/FN1/LTBP3/FERMT1/TSKU/BMPR1A/ITGB6 12 GO:0034329 cell junction assembly 49/1115 420/18722 5.17652041734682e-06 0.00040643297806198 ITGA6/LAMC1/LRP1/CDH1/ITGB4/IQGAP1/NRP1/MACF1/APP/ACTG1/DST/PLXNB1/GJA1/PLEC/NRCAM/CTNND1/PLXNB2/MYO1C/PKN2/DLG5/SLC9A1/DLG1/MPP7/FN1/PTPRA/ROCK1/RYK/FZD5/CLSTN1/GJA5/PPP1R9A/TPBG/SORBS1/S100A10/TRPV4/F11R/CLDN4/PTPRK/PKP2/CAV1/RAB13/OBSL1/ACTB/EFNA5/OCLN/VMP1/RAPGEF2/CTNNB1/RHOA 49 GO:0030048 actin filament-based movement 22/1115 127/18722 5.56476562960628e-06 0.000430583821687941 SYNE2/AKAP9/DSC2/GJA1/DSG2/MYO1C/SLC9A1/DLG1/ATP2A2/ACTN4/GJA5/GPD1L/ATP1A1/MYH10/WASL/MYO7A/DSP/PKP2/CAV1/MYO6/MYL6/WASF2 22 GO:0003151 outflow tract morphogenesis 16/1115 74/18722 5.7150330676523e-06 0.000435893736402795 LRP2/NRP2/NRP1/NIPBL/TGFBR3/BMP7/FOLR1/JAG1/GJA5/RBPJ/BMPR2/BMPR1A/FGFR2/DHRS3/ISL1/CTNNB1 16 GO:0007039 protein catabolic process in the vacuole 8/1115 19/18722 6.46194465217758e-06 0.000485920035182762 LRP2/LRP1/RNF128/TMEM106B/LAMP2/VPS13A/TPP1/CLN3 8 GO:0043588 skin development 35/1115 263/18722 6.87822415996727e-06 0.000509701467934188 EGFR/ITGA6/LAMA5/LGR5/MET/ITGB4/ANXA1/LGR4/ASAH1/ASH1L/ZFP36L1/NCOA3/EXPH5/PLEC/PTGES3/SGPP1/ST14/COL5A2/JAG1/ROCK1/PALLD/FERMT1/RBPJ/DSP/CLDN4/DHCR24/FZD6/FRAS1/OPN3/ZDHHC21/ITGB6/FGFR2/FZD3/ELOVL1/CTNNB1 35 GO:0150115 cell-substrate junction organization 19/1115 101/18722 6.96913413732829e-06 0.000509701467934188 ITGA6/LAMC1/LRP1/ITGB4/IQGAP1/NRP1/MACF1/ACTG1/DST/PLEC/SLC9A1/FN1/PTPRA/ROCK1/SORBS1/S100A10/PTPRK/EFNA5/RHOA 19 GO:0086001 cardiac muscle cell action potential 16/1115 76/18722 8.22354754917373e-06 0.000593317842770791 AKAP9/DSC2/GJA1/CALM1/ANK3/DSG2/YWHAE/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/DSP/PKP2/CAV1 16 GO:0007160 cell-matrix adhesion 32/1115 233/18722 8.75059919428749e-06 0.000620969808640525 LRP1/DAG1/ITGB1/ITGB4/BCAM/UTRN/ITGAV/CDK6/IQGAP1/NRP1/MACF1/ITGB5/ACTG1/NF1/RASA1/SLC9A1/FN1/JAG1/PTPRA/ROCK1/TRPM7/FERMT1/SORBS1/PPFIA1/S100A10/DDR1/PTPRK/EFNA5/MKLN1/ITGB6/CTNNB1/RHOA 32 GO:0090316 positive regulation of intracellular protein transport 25/1115 160/18722 8.83942788100392e-06 0.000620969808640525 CDH1/TCAF1/OAZ1/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/PCM1/TCF7L2/FZD5/KIF5B/UBE2L3/NPEPPS/GLI3/MAPK14/RAN/SREBF2/STOM/B3GAT3/TMEM30B/MAVS/ERBB2 25 GO:0050821 protein stabilization 28/1115 191/18722 9.15728105875585e-06 0.000634944461983085 GAPDH/GRN/PFN1/RPL23/NPM1/RPL5/RTN4/AAK1/PLPP3/TBL1X/CTNND1/PTGES3/HSP90AB1/SEL1L/P3H1/GNAQ/MDM4/GLMP/USP9X/LAMP2/TRIM44/DVL3/CRTAP/ZNF207/ATF7IP/HSPA1A/WFS1/CCT3 28 GO:0003279 cardiac septum development 19/1115 103/18722 9.3773786458343e-06 0.000641869546027043 LRP2/ADAMTS6/NRP2/NRP1/TGFBR3/HECTD1/BMP7/TRIP11/MDM4/JAG1/TGFBR1/GJA5/RBPJ/BMPR2/BMPR1A/FGFR2/DHRS3/ISL1/PTK7 19 GO:0008361 regulation of cell size 27/1115 181/18722 9.49831453489021e-06 0.0006419177379972 LRP1/SEMA6D/GOLGA4/NRP1/NPM1/SEMA6A/MACF1/RTN4/SEMA3F/ANO6/NRCAM/CDKL5/HSP90AB1/RB1CC1/FN1/KCNN4/RYK/SEMA4B/CLCN3/TRPV4/BMPR2/VAV3/CLN3/AKT3/SEMA7A/TMEM123/RHOA 27 GO:0051960 regulation of nervous system development 50/1115 443/18722 1.04541001681661e-05 0.000697680509972984 EGFR/LRP2/SPINT1/LRP1/DAG1/IL6ST/MME/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/DICER1/CTSC/PLXNB1/NF1/SEMA3F/SERPINF1/CUX1/BMP7/CDKL5/PLXNB2/PLXNA1/DLG5/MAN2A1/DLG1/FN1/PCM1/UFL1/RYK/SEMA4B/CLSTN1/PRTG/PRKCI/TPBG/GLI3/BMPR2/DHX36/SPEN/SEMA7A/TRAK2/BMPR1A/OBSL1/PPP3CA/REST/FZD3/PLAG1/RAPGEF2/CTNNB1 50 GO:0060562 epithelial tube morphogenesis 40/1115 325/18722 1.06995717488798e-05 0.000705247081077401 LRP2/LAMA5/SPINT1/DAG1/LGR5/MET/PFN1/LRP5/LGR4/NRP1/PBX1/COL4A1/MAGED1/HECTD1/BMP7/PLXNB2/DLG5/ST14/DLG1/FOLR1/DVL3/MTSS1/RBPJ/GLI3/MIB1/DDR1/FOXP1/SETD2/FZD6/COBL/AHI1/PHACTR4/PKD2/FGFR2/FZD3/PTK7/GPC3/CTNNB1/IRX2/RHOA 40 GO:1990138 neuron projection extension 26/1115 172/18722 1.08464704694901e-05 0.000706211046787895 LRP1/ITGB1/NRP2/SEMA6D/GOLGA4/IQGAP1/NRP1/SEMA6A/MACF1/RTN4/SEMA3F/NRCAM/CDKL5/HSP90AB1/PLXNA1/FN1/USP9X/RYK/SEMA4B/C9orf72/BMPR2/DDR1/SEMA7A/ITSN2/CYFIP2/CTNNB1 26 GO:1905146 lysosomal protein catabolic process 7/1115 15/18722 1.09911162160605e-05 0.000707006861175267 LRP2/LRP1/TMEM106B/LAMP2/VPS13A/TPP1/CLN3 7 GO:0051222 positive regulation of protein transport 38/1115 303/18722 1.14684974268054e-05 0.000728932235258502 EGFR/LRP1/CDH1/TCAF1/WLS/DYNLL1/OAZ1/PPIA/GJA1/EXPH5/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/KCNN4/PCM1/TCF7L2/FZD5/KIF5B/UBE2L3/NPEPPS/FRMD4A/GLI3/MYH10/CLN3/MAPK14/RAN/ACSL3/SREBF2/STOM/B3GAT3/TMEM30B/ISL1/MAVS/ERBB2 38 GO:0090150 establishment of protein localization to membrane 34/1115 260/18722 1.35122987127387e-05 0.000848731327380139 EGFR/TCAF1/GOLGA4/NACA/SEC62/MACF1/CALM1/ANK3/SPTBN1/MYO1C/KRT18/SEC63/SEC61A1/EMC1/CLSTN1/HSPA5/NPC1/PRKCI/TRAM1/SSR1/LYPLA1/ZDHHC20/RAB3GAP1/CCDC47/SIL1/EMC10/CLN3/RAB3GAP2/ACSL3/ZDHHC21/STOM/RAB31/TRAM2/ERBB2 34 GO:0019058 viral life cycle 39/1115 317/18722 1.38621879180632e-05 0.000860583968541155 EGFR/DAG1/CD46/ITGB1/ITGAV/NRP1/HACD3/SLC52A1/ITGB5/DPP4/CD74/PPIA/EEA1/CTSB/SLC1A5/FURIN/HSP90AB1/PKN2/SCARB2/DDB1/PCBP2/TFRC/P4HB/RPSA/WWP1/MPHOSPH8/NPC1/TOP2B/SMPD1/F11R/LY6E/SLC52A2/CAV1/STOM/ITGB6/TRIM38/MAVS/TRIM13/HSPA1A 39 GO:0090263 positive regulation of canonical Wnt signaling pathway 19/1115 106/18722 1.44026705838273e-05 0.000883860439621312 EGFR/LGR5/KANK1/LGR4/WLS/TBL1X/USP47/UBR5/USP34/TNKS2/RBPJ/TBL1XR1/WNK1/CAV1/XIAP/FGFR2/SMURF2/PTK7/GPC3 19 GO:0071526 semaphorin-plexin signaling pathway 11/1115 40/18722 1.48393940795458e-05 0.000897736587016395 MET/NRP2/SEMA6D/NRP1/SEMA6A/PLXNB1/SEMA3F/PLXNB2/PLXNA1/SEMA4B/SEMA7A 11 GO:0031346 positive regulation of cell projection organization 42/1115 353/18722 1.49650788995054e-05 0.000897736587016395 ITGA6/TENM3/LRP1/GRN/PFN1/GOLGA4/IQGAP1/NRP1/MACF1/PLXNB1/SERPINF1/CUX1/TMEM30A/BMP7/CDKL5/PLXNB2/P3H1/PLXNA1/VLDLR/SCARB2/KIDINS220/FN1/CREB3L2/TGFBR1/TMEM106B/HSPA5/NCKAP1/PRKCI/PPP1R9A/DVL3/BMPR2/WASL/DHX36/COBL/SEMA7A/CFLAR/OBSL1/ABI2/OCLN/PTK7/RAPGEF2/WASF2 42 GO:0015711 organic anion transport 42/1115 354/18722 1.60277054479358e-05 0.000934101757149437 LRP2/SLC26A2/ITGB1/ANXA1/SLC2A1/PSAP/SLC52A1/SLC19A1/SLC38A2/SLC22A11/SLC43A2/GJA1/SLC16A12/SLC1A5/SLC17A5/ARL6IP5/P2RX4/SLC5A6/SLC16A4/SLC38A9/FOLR1/SLC7A6/SERINC3/SLC35D1/CD47/SLC16A1/SLC4A2/SLC38A1/SLC7A2/SLC1A3/SLC35B4/SLC13A3/SLC29A1/PLEKHA8/RAB3GAP1/CLN3/SLC27A6/SLC52A2/ABCD3/SLC16A2/SLC2A8/PLA2R1 42 GO:1904951 positive regulation of establishment of protein localization 39/1115 319/18722 1.60407609572838e-05 0.000934101757149437 EGFR/LRP1/CDH1/TCAF1/WLS/DYNLL1/OAZ1/PPIA/GJA1/EXPH5/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/KCNN4/PCM1/TCF7L2/FZD5/KIF5B/UBE2L3/NPEPPS/FRMD4A/GLI3/MYH10/CLN3/MAPK14/RAN/ACSL3/SREBF2/STOM/B3GAT3/TMEM30B/ISL1/MAVS/ERBB2/CCT3 39 GO:0001649 osteoblast differentiation 31/1115 229/18722 1.60961531481079e-05 0.000934101757149437 FBN2/CRIM1/IL6ST/RRBP1/LRP5/CDK6/LGR4/NF1/BMP7/CLTC/ATP6AP1/JAG1/UFL1/SUCO/TMEM64/GLI3/BMPR2/CCDC47/SEMA7A/MAPK14/BMPR1A/HNRNPC/REST/FGFR2/CAT/ACVR2B/CTNNB1/FASN/ATRAID/SND1/HSPE1 31 GO:0050878 regulation of body fluid levels 44/1115 379/18722 1.75003396911544e-05 0.00100467003882874 EGFR/F5/IL6ST/MET/ANXA5/LMAN1/PRLR/FBLN1/ACTG1/PPIA/GJA1/TFPI/ANO6/PLEC/ATP6V1B1/GNAQ/MYL12A/COPA/GNA12/FN1/KCNN4/JMJD1C/GJA5/SLC29A1/WNK1/TRPV4/F11R/HSPB1/DDR1/VAV3/CLDN4/C1QTNF1/AK3/FZD6/MAPK14/HPS5/CAV1/CCND1/EDNRB/ACTB/ANXA2/ELOVL1/WFS1/GPAT4 44 GO:0086004 regulation of cardiac muscle cell contraction 10/1115 34/18722 1.8981643355383e-05 0.00106667071600984 AKAP9/DSC2/DSG2/DLG1/ATP2A2/GJA5/ATP1A1/DSP/PKP2/CAV1 10 GO:0071634 regulation of transforming growth factor beta production 11/1115 41/18722 1.91962576314145e-05 0.00106667071600984 CD46/ITGAV/ITGB8/LTBP1/FURIN/HSP90AB1/FN1/FERMT1/TSKU/BMPR1A/ITGB6 11 GO:0014032 neural crest cell development 16/1115 81/18722 1.92629560388325e-05 0.00106667071600984 LAMA5/NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/BMP7/FOLR1/FN1/JAG1/SEMA4B/SEMA7A/EDNRB/PHACTR4/BMPR1A/ISL1 16 GO:0006986 response to unfolded protein 22/1115 137/18722 1.9379482946798e-05 0.00106667071600984 EDEM3/STT3B/HSP90AB1/ATF6/ERLEC1/CREB3L2/UFL1/UBXN4/HSPA5/AMFR/TRAM1/TMEM33/DNAJC3/HSPB1/JKAMP/CCND1/PPP1R15B/CREBRF/DNAJA1/HSPA1A/WFS1/HSPE1 22 GO:1903829 positive regulation of cellular protein localization 35/1115 276/18722 1.97973219031138e-05 0.00107855001674208 EGFR/LRP1/CDH1/TCAF1/ITGB1/IQGAP1/NPM1/ATP2B4/RTN4/SLC5A3/ANK3/SPTBN1/TPR/HSP90AB1/MYO1C/UBR5/DLG1/TFRC/FZD5/KIF5B/UBE2L3/PRKCI/NPEPPS/GPD1L/SORBS1/GLI3/CLN3/MAPK14/RAN/ACSL3/SREBF2/STOM/MAVS/ERBB2/CCT3 35 GO:0016358 dendrite development 32/1115 243/18722 2.0814344332701e-05 0.00111470999452265 ITGB1/IQGAP1/NRP1/APP/CFL1/CUX1/BMP7/CDKL5/ADAM10/SLC11A2/DLG5/VLDLR/KIDINS220/TMEM106B/PPP1R9A/TPBG/WASL/DHX36/COBL/CAMSAP2/ASAP1/TRAK2/OBSL1/PPP3CA/ABI2/UBA6/RERE/C21orf91/RAPGEF2/CDC20/ARF4/RHOA 32 GO:0032271 regulation of protein polymerization 31/1115 232/18722 2.08786288541421e-05 0.00111470999452265 AKAP9/MET/KANK1/PFN1/IQGAP2/CLIP1/SCIN/RPS3/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/CAMSAP2/ABI2/CYFIP2/OCLN/HSPA1A/RHOA/WASF2 31 GO:0060840 artery development 18/1115 100/18722 2.26463804015022e-05 0.00119711905904574 LRP2/ADAMTS6/LRP1/NRP1/NF1/HECTD1/FOLR1/JAG1/TGFBR1/GJA5/RBPJ/GLI3/BMPR2/AKT3/BMPR1A/PKD2/ACVR2B/HPGD 18 GO:0090596 sensory organ morphogenesis 33/1115 256/18722 2.42134906335721e-05 0.00126741006365335 FBN1/FBN2/TENM3/EFEMP1/LRP5/NIPBL/NF1/BMP7/TUG1/ATP6V1B1/MAN2A1/COL5A2/JAG1/FZD5/FAT1/RPL38/PRKCI/PTPRM/GLI3/MYO7A/NAGLU/FZD6/AHI1/TSKU/MYO6/PHACTR4/OBSL1/ABI2/FGFR2/FZD3/PTK7/CTNNB1/SOD1 33 GO:0010721 negative regulation of cell development 26/1115 180/18722 2.45758481182846e-05 0.00127388789420895 FBN1/SEMA6D/KANK1/NRP1/SEMA6A/FBLN1/RTN4/DICER1/NF1/SEMA3F/BMP7/ACTN4/PCM1/RYK/SEMA4B/PRTG/SEMA7A/S1PR3/TRAK2/EDNRB/BMPR1A/EFNA5/PPP3CA/REST/RAPGEF2/CTNNB1 26 GO:0010765 positive regulation of sodium ion transport 10/1115 35/18722 2.5163801900788e-05 0.00129182248411834 PRSS8/ANK3/SLC9A1/ACTN4/KIF5B/AHCYL1/GPD1L/DMD/WNK1/PKP2 10 GO:0048675 axon extension 20/1115 120/18722 2.62920626724521e-05 0.00132213153552817 LRP1/ITGB1/NRP2/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/SEMA3F/NRCAM/CDKL5/HSP90AB1/FN1/USP9X/RYK/SEMA4B/C9orf72/BMPR2/SEMA7A 20 GO:0032388 positive regulation of intracellular transport 28/1115 202/18722 2.6351890416777e-05 0.00132213153552817 CDH1/TCAF1/PGAP1/OAZ1/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/PCM1/DYNC1H1/TCF7L2/FZD5/KIF5B/UBE2L3/NPEPPS/GLI3/MAPK14/RAN/SREBF2/STOM/B3GAT3/TMEM30B/ANXA2/MAVS/ERBB2 28 GO:0008380 RNA splicing 48/1115 434/18722 2.64971107513607e-05 0.00132213153552817 AHNAK/HNRNPA1/SON/NPM1/MBNL3/MBNL2/SLC38A2/RBM25/YBX1/LUC7L3/DDX17/SF1/RBM6/RBM5/SRSF3/MBNL1/HNRNPH1/TCERG1/ZC3H13/PNN/SCAF11/RPS13/PPIG/THOC2/SF3B1/PRPF38B/ZNF638/PTBP3/CELF1/HNRNPA2B1/ESRP1/CDK12/TRA2B/HNRNPC/REST/CDK13/SREK1/NCL/SNRPD2/HSPA1A/SNRPF/SAP18/SNRPD1/FUS/SRSF9/SNRPB/LSM3/HNRNPA3 48 GO:0031589 cell-substrate adhesion 42/1115 363/18722 2.92251360165997e-05 0.0014265988923478 ITGA6/LAMA5/LAMC1/LRP1/DAG1/LAMB1/ITGB1/ITGB4/BCAM/KANK1/UTRN/ITGAV/CDK6/IQGAP1/NRP1/FBLN1/MACF1/ITGB5/ACTG1/NF1/GCNT2/RASA1/CCDC80/SLC9A1/ACTN4/FN1/JAG1/PTPRA/ROCK1/TRPM7/P4HB/FERMT1/SORBS1/PPFIA1/S100A10/DDR1/PTPRK/EFNA5/MKLN1/ITGB6/CTNNB1/RHOA 42 GO:0000209 protein polyubiquitination 31/1115 236/18722 2.92657853225113e-05 0.0014265988923478 PPIA/HECTD1/KLHL42/UBR5/NHLRC3/LNPEP/RNF217/TRIM56/WWP1/TTC3/UBE2L3/TNKS2/NPEPPS/TRIM44/AMFR/TRIP12/SKP2/UBE4A/RNF19A/DDA1/XIAP/UBE2H/RNF167/UBE4B/SKP1/TRIM38/SHPRH/SMURF2/RC3H1/UBE2C/CTNNB1 31 GO:0050769 positive regulation of neurogenesis 30/1115 225/18722 2.93923727586174e-05 0.0014265988923478 EGFR/LRP2/SPINT1/LRP1/DAG1/IL6ST/MME/GOLGA4/NRP1/MACF1/DICER1/PLXNB1/SERPINF1/CUX1/CDKL5/PLXNB2/PLXNA1/MAN2A1/FN1/UFL1/PRKCI/GLI3/BMPR2/DHX36/SPEN/SEMA7A/OBSL1/FZD3/PLAG1/CTNNB1 30 GO:0098911 regulation of ventricular cardiac muscle cell action potential 6/1115 12/18722 2.98028007566004e-05 0.00143348786702243 DSC2/DSG2/DLG1/DSP/PKP2/CAV1 6 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 21/1115 131/18722 3.05279266149971e-05 0.00145525535890598 FBN1/FBN2/GLG1/TGFBR3/LTBP1/HSP90AB1/FOLR1/ZNF451/HSPA5/FERMT1/CHST11/TRIM33/LATS2/ADAM17/SMAD2/CFLAR/CAV1/SMURF2/CREBBP/HSPA1A/CDKN1C 21 GO:0050673 epithelial cell proliferation 48/1115 437/18722 3.1615752438139e-05 0.00149377435634711 EGFR/LAMC1/LGR5/LAMB1/NRP2/GRN/CDK6/LGR4/FLT1/NRP1/RTN4/ZFP36L1/NF1/GJA1/TGFBR3/PRKDC/SERPINF1/MAGED1/B4GALT1/DLG1/TGFBR1/TCF7L2/RICTOR/FERMT1/NR2F2/NCSTN/MTSS1/ADAM17/PTPRM/NFIB/BMPR2/EMC10/AKT3/HMGB1/PTPRK/CFLAR/CAV1/CCND1/SUZ12/EDNRB/BMPR1A/FGFR2/ISL1/GPC3/ERBB2/CTNNB1/CDKN1C/SERPINB1 48 GO:0071826 ribonucleoprotein complex subunit organization 30/1115 227/18722 3.48229985721707e-05 0.00163087709979666 RPL23A/RPL3/RPL13A/RPL6/RPLP0/RPL5/DICER1/PRKDC/LUC7L3/PTGES3/SF1/HSP90AB1/RBM5/RPL24/SCAF11/KIF5B/RPSA/SF3B1/RPL38/EIF3A/CELF1/AGO2/EIF2S2/ATM/SNRPD2/EIF3H/SNRPF/SNRPD1/SRSF9/SNRPB 30 GO:0072659 protein localization to plasma membrane 35/1115 284/18722 3.62991058889944e-05 0.00168522544644644 EGFR/LAMA5/LRP1/CDH1/ITGB1/GOLGA4/MACF1/ATP2B4/ANK3/HECTD1/SPTBN1/ARL6IP5/CLTC/KRT18/MYL12A/DLG1/ROCK1/DENND4C/KIF5B/PRKCI/TPBG/LYPLA1/SORBS1/PPFIA1/S100A10/F11R/CLN3/PKP2/RAB13/ACSL3/APPL1/RAB31/ACTB/ANXA2/RAPGEF2 35 GO:0048193 Golgi vesicle transport 36/1115 296/18722 3.7490259825712e-05 0.00171077348042288 LMAN1/GOLGA4/MACF1/PLPP3/PGAP1/CUX1/ANK3/SPTBN1/SCAMP2/USO1/KRT18/VPS13C/COPA/TRIP11/GCC2/CREB3L2/RAB6A/VPS13A/TMED4/SEC31A/PRKCI/MON2/LYPLA1/ERGIC2/MIA3/YIPF4/TMED1/CLN3/RAB13/ACSL3/RAB31/TMEM115/CYTH3/TAPBP/ARF4/ARF5 36 GO:0051258 protein polymerization 36/1115 296/18722 3.7490259825712e-05 0.00171077348042288 AKAP9/MET/KANK1/PFN1/IQGAP2/CLIP1/SCIN/RPS3/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/TTC17/RICTOR/NCKAP1/PPP1R9A/KANK4/TRPV4/TMSB4X/WASL/ARPC3/COBL/CAMSAP2/ZNF207/ABI2/CYFIP2/OCLN/UBE2C/HSPA1A/RHOA/WASF2 36 GO:0001763 morphogenesis of a branching structure 27/1115 196/18722 4.07273973702635e-05 0.00180402496767939 LAMA5/SPINT1/DAG1/MET/LRP5/LGR4/NRP1/PBX1/RTN4/COL4A1/MAGED1/BMP7/PLXNA1/DLG5/ST14/DLG1/FZD5/GLI3/BTBD7/DDR1/SETD2/FEM1B/PKD2/FGFR2/RERE/GPC3/CTNNB1 27 GO:0031032 actomyosin structure organization 27/1115 196/18722 4.07273973702635e-05 0.00180402496767939 KRT19/MET/ITGB1/KRT8/PFN1/NRP1/ITGB5/ACTG1/PLEC/FRMD6/SLC9A1/AKAP13/ARHGAP28/ROCK1/CD47/TGFBR1/TRPM7/PPP1R9A/SORBS1/PPFIA1/S100A10/F11R/MYH10/CFLAR/OBSL1/RHOA/WASF2 27 GO:0033157 regulation of intracellular protein transport 30/1115 229/18722 4.11478550920092e-05 0.00180402496767939 CDH1/TCAF1/LMAN1/OAZ1/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/ERLEC1/PTPN14/GCC2/PCM1/TCF7L2/FZD5/KIF5B/FERMT1/UBE2L3/NPEPPS/GLI3/MAPK14/RAN/SREBF2/STOM/B3GAT3/TMEM30B/MAVS/ERBB2 30 GO:0008360 regulation of cell shape 23/1115 154/18722 4.16570967755886e-05 0.00180402496767939 DAG1/ANXA1/PLXNB1/ALDOA/BRWD1/HEXB/MYL12B/PLXNB2/RASA1/PLXNA1/MYL12A/DLG1/ARHGAP18/FN1/PHIP/FMNL2/RHOBTB3/F11R/MYH10/RHOBTB1/MKLN1/RHOA/CDC42SE1 23 GO:0014031 mesenchymal cell development 16/1115 86/18722 4.18726073074565e-05 0.00180402496767939 LAMA5/NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/BMP7/FOLR1/FN1/JAG1/SEMA4B/SEMA7A/EDNRB/PHACTR4/BMPR1A/ISL1 16 GO:1990778 protein localization to cell periphery 39/1115 333/18722 4.2510957186591e-05 0.00180402496767939 EGFR/LAMA5/LRP1/DAG1/CDH1/ITGB1/GOLGA4/MACF1/ATP2B4/ANK3/HECTD1/SPTBN1/ARL6IP5/CLTC/ADAM10/KRT18/MYL12A/DLG1/ROCK1/CLSTN1/DENND4C/KIF5B/PRKCI/TPBG/LYPLA1/SORBS1/PPFIA1/S100A10/F11R/CLN3/PKP2/CAV1/RAB13/ACSL3/APPL1/RAB31/ACTB/ANXA2/RAPGEF2 39 GO:0048880 sensory system development 43/1115 381/18722 4.27192067614395e-05 0.00180402496767939 FBN1/FBN2/TENM3/ATP2B1/EFEMP1/LRP5/FLT1/NRP1/PBX1/ATP2B4/NIPBL/COL4A1/NF1/SERPINF1/BMP7/TUG1/ATF6/MAN2A1/RPL24/DLG1/COL5A2/JAG1/TGFBR1/FZD5/FAT1/MEIS2/PRKCI/PTPRM/GLI3/BMPR2/MYO7A/NAGLU/RAB3GAP1/HMGB1/AHI1/TSKU/PHACTR4/OBSL1/ABI2/ISL1/FREM2/ACVR2B/CTNNB1 43 GO:0050678 regulation of epithelial cell proliferation 43/1115 381/18722 4.27192067614395e-05 0.00180402496767939 EGFR/LAMC1/LAMB1/NRP2/GRN/CDK6/FLT1/NRP1/RTN4/ZFP36L1/NF1/GJA1/TGFBR3/PRKDC/SERPINF1/MAGED1/B4GALT1/DLG1/TGFBR1/TCF7L2/RICTOR/NR2F2/MTSS1/ADAM17/PTPRM/NFIB/BMPR2/EMC10/AKT3/HMGB1/PTPRK/CFLAR/CAV1/CCND1/SUZ12/EDNRB/BMPR1A/FGFR2/ISL1/GPC3/ERBB2/CTNNB1/CDKN1C 43 GO:0001508 action potential 21/1115 134/18722 4.3124593586325e-05 0.00180402496767939 AKAP9/DSC2/GJA1/CALM1/ANK3/DSG2/P2RX4/GNAQ/YWHAE/USP53/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/DSP/CLN3/PKP2/CAV1 21 GO:0010720 positive regulation of cell development 36/1115 298/18722 4.32506454135535e-05 0.00180402496767939 EGFR/LRP2/SPINT1/LRP1/DAG1/IL6ST/MME/GOLGA4/NRP1/MACF1/DICER1/PLXNB1/PRKDC/SERPINF1/CUX1/CDKL5/PLXNB2/PLXNA1/MAN2A1/FN1/ATP6AP1/UFL1/P4HB/PRKCI/S100A10/GLI3/F11R/BMPR2/DHX36/SPEN/SEMA7A/S1PR2/OBSL1/FZD3/PLAG1/CTNNB1 36 GO:0031647 regulation of protein stability 36/1115 298/18722 4.32506454135535e-05 0.00180402496767939 GAPDH/GRN/PFN1/RPL23/NPM1/RPL5/RTN4/AAK1/PLPP3/TBL1X/PRKDC/RNF128/CTNND1/PTGES3/HSP90AB1/SEL1L/P3H1/USP47/GNAQ/MDM4/GLMP/B4GALT5/USP9X/LAMP2/TRIM44/DVL3/CRTAP/CMTM6/DDI2/CTSA/ZNF207/ATF7IP/CREBBP/HSPA1A/WFS1/CCT3 36 GO:1903311 regulation of mRNA metabolic process 35/1115 288/18722 4.85723812055584e-05 0.00198777668525001 HNRNPA1/SON/NPM1/MBNL3/MBNL2/ZFP36L1/RBM25/YBX1/TNRC6B/DDX17/SF1/RBM5/SRSF3/MBNL1/ROCK1/AHCYL1/CNOT6L/PUM2/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/TRA2B/HNRNPC/REST/MOV10/NCL/RC3H1/HNRNPD/SAP18/FUS/SRSF9/YBX3 35 GO:0001654 eye development 42/1115 371/18722 4.86510119424633e-05 0.00198777668525001 FBN1/FBN2/TENM3/ATP2B1/EFEMP1/LRP5/FLT1/NRP1/PBX1/ATP2B4/NIPBL/COL4A1/NF1/SERPINF1/BMP7/TUG1/ATF6/MAN2A1/RPL24/DLG1/COL5A2/JAG1/TGFBR1/FZD5/FAT1/MEIS2/PRKCI/PTPRM/GLI3/BMPR2/MYO7A/NAGLU/RAB3GAP1/HMGB1/AHI1/TSKU/PHACTR4/OBSL1/ABI2/FREM2/ACVR2B/CTNNB1 42 GO:0022618 ribonucleoprotein complex assembly 29/1115 220/18722 4.89952408320757e-05 0.00198777668525001 RPL23A/RPL3/RPL13A/RPL6/RPLP0/RPL5/DICER1/PRKDC/LUC7L3/PTGES3/SF1/HSP90AB1/RBM5/RPL24/SCAF11/RPSA/SF3B1/RPL38/EIF3A/CELF1/AGO2/EIF2S2/ATM/SNRPD2/EIF3H/SNRPF/SNRPD1/SRSF9/SNRPB 29 GO:0035272 exocrine system development 11/1115 45/18722 4.95175686717085e-05 0.00198777668525001 LAMA5/DAG1/WLS/NRP1/BMP7/IGSF3/PLXNA1/NFIB/BTBD7/TFCP2L1/FGFR2 11 GO:0051180 vitamin transport 11/1115 45/18722 4.95175686717085e-05 0.00198777668525001 LRP2/SLC2A1/SLC52A1/SLC19A1/SLC19A3/SLC5A6/FOLR1/LMBRD1/TTPA/SLC52A2/SLC2A8 11 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 6/1115 13/18722 5.25554706963482e-05 0.0020939825227448 NRP2/NRP1/PLXNB1/SEMA3F/PLXNB2/PLXNA1 6 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 32/1115 256/18722 5.8592848475361e-05 0.00231723865192557 FBN1/FBN2/LRP2/CRIM1/LRP1/FSTL1/GLG1/TGFBR3/LTBP1/BMP7/HSP90AB1/FOLR1/ZNF451/TGFBR1/HSPA5/FERMT1/CHST11/TRIM33/RBPJ/LATS2/ADAM17/BMPR2/SMAD2/CAV1/XIAP/BMPR1A/SMURF2/CREBBP/GPC3/ACVR2B/HSPA1A/CDKN1C 32 GO:0060560 developmental growth involved in morphogenesis 30/1115 234/18722 6.17529786535796e-05 0.00242425847817251 LRP1/ITGB1/NRP2/SEMA6D/GOLGA4/IQGAP1/NRP1/SEMA6A/MACF1/APP/RTN4/SEMA3F/NRCAM/CDKL5/HSP90AB1/PLXNA1/FN1/USP9X/RYK/SEMA4B/C9orf72/BMPR2/DDR1/COBL/SEMA7A/ITSN2/FGFR2/CYFIP2/PTK7/CTNNB1 30 GO:0150063 visual system development 42/1115 375/18722 6.22563172441707e-05 0.0024261786698294 FBN1/FBN2/TENM3/ATP2B1/EFEMP1/LRP5/FLT1/NRP1/PBX1/ATP2B4/NIPBL/COL4A1/NF1/SERPINF1/BMP7/TUG1/ATF6/MAN2A1/RPL24/DLG1/COL5A2/JAG1/TGFBR1/FZD5/FAT1/MEIS2/PRKCI/PTPRM/GLI3/BMPR2/MYO7A/NAGLU/RAB3GAP1/HMGB1/AHI1/TSKU/PHACTR4/OBSL1/ABI2/FREM2/ACVR2B/CTNNB1 42 GO:0030041 actin filament polymerization 26/1115 190/18722 6.28926431968673e-05 0.00243321610165271 KANK1/PFN1/IQGAP2/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/TTC17/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/COBL/ABI2/CYFIP2/RHOA/WASF2 26 GO:0009791 post-embryonic development 15/1115 80/18722 6.57079820821426e-05 0.00250582083097542 FBN1/EFEMP1/ASH1L/ATRX/TGFBR1/FZD5/IREB2/CHST11/MYO7A/ZFX/CCDC47/SMAD2/AGO2/ARID5B/FGFR2 15 GO:0032204 regulation of telomere maintenance 15/1115 80/18722 6.57079820821426e-05 0.00250582083097542 HNRNPA1/ATRX/SMG1/TNKS2/PKIB/XRN1/DHX36/DCP2/HNRNPA2B1/YLPM1/HNRNPC/ATM/CTNNB1/HNRNPD/CCT3 15 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 20/1115 128/18722 6.79015564583272e-05 0.00257110929029084 FBN1/FBN2/GLG1/TGFBR3/LTBP1/HSP90AB1/FOLR1/ZNF451/HSPA5/FERMT1/CHST11/TRIM33/LATS2/ADAM17/SMAD2/CAV1/SMURF2/CREBBP/HSPA1A/CDKN1C 20 GO:0035966 response to topologically incorrect protein 23/1115 159/18722 6.92227318563371e-05 0.00260267722099284 EDEM3/STT3B/DNAJB14/HSP90AB1/ATF6/ERLEC1/CREB3L2/UFL1/UBXN4/HSPA5/AMFR/TRAM1/TMEM33/DNAJC3/HSPB1/JKAMP/CCND1/PPP1R15B/CREBRF/DNAJA1/HSPA1A/WFS1/HSPE1 23 GO:1903115 regulation of actin filament-based movement 10/1115 39/18722 7.00848182035377e-05 0.00261666324747334 AKAP9/DSC2/DSG2/DLG1/ATP2A2/GJA5/ATP1A1/DSP/PKP2/CAV1 10 GO:0030178 negative regulation of Wnt signaling pathway 24/1115 170/18722 7.21499242495695e-05 0.00267505864978091 LRP1/RNF43/ZNRF3/CTNND1/TCF7L2/FERMT1/TPBG/AMFR/SCYL2/SIAH2/LATS2/RBMS3/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/TSKU/CAV1/CSNK1A1/RNF213/ISL1/GPC3 24 GO:0072337 modified amino acid transport 9/1115 32/18722 7.35246762201231e-05 0.00270722928509819 LRP2/SLC19A1/SLC38A2/GJA1/SLC16A12/SLC5A6/FOLR1/SLC22A5/SLC13A3 9 GO:0002028 regulation of sodium ion transport 16/1115 90/18722 7.43180504925952e-05 0.00271769912041072 UTRN/ATP2B4/PRSS8/ANK3/P2RX4/SLC9A1/DLG1/ACTN4/KIF5B/AHCYL1/GPD1L/DMD/ATP1A1/WNK1/PKP2/STOM 16 GO:0042273 ribosomal large subunit biogenesis 14/1115 72/18722 7.55181144591116e-05 0.00274279736800814 RPL23A/RPL3/RPL6/RPLP0/RPL7/NPM1/RPL5/RPL7A/RPL14/RPL26/RPL24/RPL10A/RPL38/RPL35 14 GO:0048638 regulation of developmental growth 38/1115 330/18722 7.63181139811705e-05 0.0027531243955775 LRP1/SEMA6D/GOLGA4/NRP1/SEMA6A/LGMN/MACF1/SLC6A4/APP/ADRB1/RTN4/NIPBL/SEMA3F/GJA1/TGFBR3/PRKDC/NRCAM/CDKL5/FN1/TGFBR1/RYK/SEMA4B/TNKS2/JARID2/RBPJ/LATS2/BMPR2/WWC2/CELF1/SEMA7A/MAPK14/BMPR1A/ITSN2/INSR/FGFR2/GPAT4/SOD1/YBX3 38 GO:0030833 regulation of actin filament polymerization 24/1115 171/18722 7.92874615117782e-05 0.00284104534906969 KANK1/PFN1/IQGAP2/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/ABI2/CYFIP2/RHOA/WASF2 24 GO:0001701 in utero embryonic development 41/1115 367/18722 8.01967144038312e-05 0.0028544683880137 SPINT1/KRT19/ITGB1/KRT8/N4BP2L2/RTN4/ZFP36L1/YBX1/HECTD1/BMP7/BPTF/FURIN/ADAM10/BIRC6/BTF3/ST14/MAN2A1/MBNL1/KIDINS220/TGFBR1/FZD5/CHST11/NR2F2/AMOT/RBPJ/GLI3/MIB1/SMAD2/SETD2/LY6E/RBBP6/CPT2/SH3PXD2A/HM13/BMPR1A/PKD2/FGFR2/EIF2S2/MGAT1/CTNNB1/YBX3 41 GO:0051962 positive regulation of nervous system development 33/1115 272/18722 8.15543594621967e-05 0.00288172943290974 EGFR/LRP2/SPINT1/LRP1/DAG1/IL6ST/MME/GOLGA4/NRP1/MACF1/DICER1/PLXNB1/SERPINF1/CUX1/CDKL5/PLXNB2/PLXNA1/DLG5/MAN2A1/FN1/UFL1/CLSTN1/PRKCI/TPBG/GLI3/BMPR2/DHX36/SPEN/SEMA7A/OBSL1/FZD3/PLAG1/CTNNB1 33 GO:0071383 cellular response to steroid hormone stimulus 27/1115 204/18722 8.20421190863982e-05 0.00288172943290974 EGFR/ATP2B1/ANXA1/ZFP36L1/TFPI/SERPINF1/DDX17/BMP7/PTGES3/NR3C1/ESRRG/UBR5/NCOR1/GSTP1/UFL1/ARID1A/UBE2L3/NPC1/SKP2/ATP1A1/FOXP1/PAQR7/CFLAR/REST/ISL1/DNAJA1/RHOA 27 GO:0014812 muscle cell migration 18/1115 110/18722 8.38416637367478e-05 0.00291865495474924 LRP1/ANXA1/SEMA6D/IQGAP1/NRP1/S100A11/PLXNA1/GNA12/NET1/GSTP1/ADAMTS1/ROCK1/DDR1/S1PR2/PDGFD/BMPR1A/FOXO4/RHOA 18 GO:0003205 cardiac chamber development 23/1115 161/18722 8.41867134353592e-05 0.00291865495474924 LRP2/ADAMTS6/NRP2/NRP1/TGFBR3/HECTD1/BMP7/TRIP11/MDM4/JAG1/ADAMTS1/TGFBR1/GJA5/RBPJ/BMPR2/DSP/LY6E/PKP2/BMPR1A/FGFR2/DHRS3/ISL1/PTK7 23 GO:0014033 neural crest cell differentiation 16/1115 91/18722 8.52629728191953e-05 0.00293689685084957 LAMA5/NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/BMP7/FOLR1/FN1/JAG1/SEMA4B/SEMA7A/EDNRB/PHACTR4/BMPR1A/ISL1 16 GO:0001892 embryonic placenta development 15/1115 82/18722 8.82719798647106e-05 0.00302105192626724 SPINT1/KRT19/KRT8/ZFP36L1/HECTD1/BMP7/BPTF/BIRC6/ST14/FZD5/NR2F2/RBPJ/SETD2/PKD2/FGFR2 15 GO:0048024 regulation of mRNA splicing, via spliceosome 17/1115 101/18722 9.12897552928921e-05 0.00310443314336784 HNRNPA1/SON/NPM1/MBNL3/MBNL2/RBM25/DDX17/SF1/RBM5/SRSF3/MBNL1/CELF1/TRA2B/REST/NCL/SAP18/SRSF9 17 GO:0008154 actin polymerization or depolymerization 28/1115 217/18722 9.57153146711396e-05 0.00323432952550136 KANK1/PFN1/IQGAP2/CFL1/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/TTC17/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/COBL/ABI2/CYFIP2/RHOA/WASF2/DSTN 28 GO:0010976 positive regulation of neuron projection development 23/1115 163/18722 0.000101968977325789 0.00338302162939966 ITGA6/TENM3/LRP1/GRN/IQGAP1/SERPINF1/TMEM30A/BMP7/PLXNB2/P3H1/VLDLR/SCARB2/KIDINS220/CREB3L2/TMEM106B/HSPA5/PRKCI/PPP1R9A/DHX36/COBL/CFLAR/PTK7/RAPGEF2 23 GO:0007040 lysosome organization 14/1115 74/18722 0.00010311492968405 0.00338302162939966 GRN/ABCA1/GAA/HEXB/SCARB2/SYT7/GNPTAB/TMEM106B/CLN5/TPP1/HOOK2/MYO7A/NAGLU/CLN3 14 GO:0048844 artery morphogenesis 14/1115 74/18722 0.00010311492968405 0.00338302162939966 LRP2/LRP1/NRP1/NF1/FOLR1/JAG1/TGFBR1/GJA5/RBPJ/BMPR2/AKT3/BMPR1A/PKD2/HPGD 14 GO:0080171 lytic vacuole organization 14/1115 74/18722 0.00010311492968405 0.00338302162939966 GRN/ABCA1/GAA/HEXB/SCARB2/SYT7/GNPTAB/TMEM106B/CLN5/TPP1/HOOK2/MYO7A/NAGLU/CLN3 14 GO:0071900 regulation of protein serine/threonine kinase activity 40/1115 359/18722 0.000103283859447864 0.00338302162939966 EGFR/LRP5/IQGAP1/FLT1/ATP2B4/NF1/CALM1/MAGED1/RPS3/BMP7/HSP90AB1/TAOK1/AKAP13/GSTP1/FZD5/RICTOR/NR2F2/SMPD1/DVL3/PKIB/LATS2/ADAM17/BMPR2/TAOK3/IPO7/PDGFD/CAV1/CCND1/CDK12/BMPR1A/ACTB/INSR/PKD2/DNAJA1/CKS1B/ERBB2/RAPGEF2/RHOA/CDKN1C/CDKN3 40 GO:0007369 gastrulation 25/1115 185/18722 0.00010598586141545 0.00345035679327491 COL4A2/DAG1/LAMB1/ITGB1/ITGB4/ITGAV/LRP5/WLS/RPS6/ITGB5/GJA1/BMP7/FN1/COL5A2/LMBRD1/AMOT/MMP15/WNK1/BMPR2/SMAD2/SETD2/BMPR1A/FGFR2/GPC3/CTNNB1 25 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 25/1115 186/18722 0.000115666815108821 0.00374269773252119 GAPDH/WLS/CD74/GJA1/BRD4/SLC44A2/AKAP13/TFRC/TMED4/MIER1/DHX36/CANT1/ZDHHC17/CFLAR/TAB2/REL/TLR3/TRIM38/ANKRD17/MAVS/EEF1D/TRIM13/CTNNB1/LTBR/RHOA 25 GO:0061333 renal tubule morphogenesis 14/1115 75/18722 0.000119929309131543 0.0038572444665862 LAMA5/LGR5/LGR4/PBX1/COL4A1/MAGED1/DLG1/MTSS1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 14 GO:0007431 salivary gland development 9/1115 34/18722 0.000123441117945371 0.00393307491163444 LAMA5/DAG1/NRP1/BMP7/PLXNA1/NFIB/BTBD7/TFCP2L1/FGFR2 9 GO:0018126 protein hydroxylation 8/1115 27/18722 0.000123760364329385 0.00393307491163444 ASPH/PRDX4/P3H1/P3H2/P4HB/CRTAP/PLOD1/P4HTM 8 GO:0008064 regulation of actin polymerization or depolymerization 25/1115 187/18722 0.000126128362332584 0.0039846113993708 KANK1/PFN1/IQGAP2/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/ABI2/CYFIP2/RHOA/WASF2/DSTN 25 GO:0001738 morphogenesis of a polarized epithelium 16/1115 94/18722 0.000127016595926142 0.00398906826852748 LAMA5/ACTG1/ZNRF3/DAAM1/DLG5/RYK/FAT1/DVL3/FZD6/AHI1/ACTB/FZD3/SMURF2/PTK7/GPC3/RHOA 16 GO:1903076 regulation of protein localization to plasma membrane 17/1115 104/18722 0.00013254259434383 0.00413827433451293 EGFR/LRP1/ITGB1/ATP2B4/HECTD1/SPTBN1/CLTC/DLG1/KIF5B/PRKCI/LYPLA1/SORBS1/PPFIA1/CLN3/ACSL3/APPL1/ACTB 17 GO:0060485 mesenchyme development 34/1115 291/18722 0.000134706230494865 0.00418137537565166 LAMA5/DAG1/NRP2/SEMA6D/NRP1/SEMA6A/RTN4/ZFP36L1/SEMA3F/TGFBR3/GCNT2/DDX17/BMP7/DLG5/MDM4/FOLR1/FN1/JAG1/ROCK1/TGFBR1/TCF7L2/SEMA4B/RBPJ/BMPR2/SMAD2/SEMA7A/EDNRB/PHACTR4/BMPR1A/PKD2/FGFR2/ISL1/PTK7/CTNNB1 34 GO:0015849 organic acid transport 35/1115 303/18722 0.000135567811409253 0.00418379505846244 LRP2/SLC26A2/ITGB1/ANXA1/SLC2A1/PLIN2/SLC27A2/SLC19A1/SLC38A2/SLC43A2/GJA1/SLC1A5/SLC17A5/SLC38A10/ARL6IP5/P2RX4/SLC5A6/SLC38A9/FOLR1/SLC7A6/SERINC3/SLC16A1/SLC38A1/SLC7A2/SLC1A3/CROT/SLC13A3/RAB3GAP1/CLN3/SLC27A6/CPT2/ABCD3/ACSL3/SLC16A2/PLA2R1 35 GO:0030832 regulation of actin filament length 25/1115 188/18722 0.000137424456532272 0.00419336413229248 KANK1/PFN1/IQGAP2/SCIN/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/SPTAN1/ARHGAP28/RICTOR/NCKAP1/PPP1R9A/KANK4/TMSB4X/WASL/ARPC3/ABI2/CYFIP2/RHOA/WASF2/DSTN 25 GO:0019511 peptidyl-proline hydroxylation 6/1115 15/18722 0.000138234142589151 0.00419336413229248 PRDX4/P3H1/P3H2/P4HB/CRTAP/P4HTM 6 GO:1904424 regulation of GTP binding 6/1115 15/18722 0.000138234142589151 0.00419336413229248 MET/ARHGAP28/CLN5/CCPG1/C9orf72/CSNK1A1 6 GO:0043434 response to peptide hormone 44/1115 414/18722 0.000142267349338522 0.0042913298198778 FBN1/DAG1/ATP2B1/CSH1/ANXA1/SLC2A1/KANK1/LRP5/IQGAP1/IGF1R/ZFP36L1/GJA1/TGFBR3/PRKDC/BMP7/MYO1C/USO1/VPS13C/SLC9A1/GSTP1/PHIP/PTPRA/GAB1/ROCK1/DENND4C/AHCYL1/PRKCI/SMARCC1/EPM2AIP1/SORBS1/TRPV4/SOGA1/OSBPL8/CFLAR/CAV1/RAB13/EDNRB/APPL1/RAB31/SLC2A8/INSR/CAT/GGH/FOXO4 44 GO:0090287 regulation of cellular response to growth factor stimulus 35/1115 304/18722 0.000144659474065198 0.00431800715292322 FBN1/FBN2/LRP2/CRIM1/FSTL1/GLG1/SEMA6A/ATP2B4/TGFBR3/LTBP1/HSP90AB1/MYO1C/FOLR1/ZNF451/GPC1/HSPA5/FERMT1/CHST11/TRIM33/RBPJ/LATS2/ADAM17/BMPR2/SMAD2/ZDHHC17/CFLAR/CAV1/XIAP/SMURF2/CYFIP2/CREBBP/GPC3/CTNNB1/HSPA1A/CDKN1C 35 GO:0060445 branching involved in salivary gland morphogenesis 7/1115 21/18722 0.000144769297691189 0.00431800715292322 LAMA5/DAG1/NRP1/BMP7/PLXNA1/BTBD7/FGFR2 7 GO:0048568 embryonic organ development 45/1115 427/18722 0.000145821712522879 0.00432523401755362 FBN1/FBN2/SPINT1/KRT19/KRT8/EFEMP1/PBX1/NIPBL/ZFP36L1/TEAD1/HECTD1/BMP7/BPTF/ATP6V1B1/BIRC6/ST14/DLG1/FOLR1/TGFBR1/FZD5/RPL38/CHST11/NR2F2/RBPJ/GLI3/MIB1/MYO7A/NAGLU/SMAD2/SETD2/FZD6/COBL/RBBP6/KMT2A/AHI1/MYO6/PHACTR4/BMPR1A/PKD2/TRA2B/FGFR2/FZD3/PTK7/CTNNB1/SOD1 45 GO:0048588 developmental cell growth 29/1115 234/18722 0.000148526611132376 0.00436464295417023 LRP1/ITGB1/NRP2/SEMA6D/GOLGA4/IQGAP1/NRP1/SEMA6A/MACF1/APP/RTN4/SEMA3F/NRCAM/CDKL5/HSP90AB1/PLXNA1/AKAP13/FN1/USP9X/RYK/SEMA4B/C9orf72/BMPR2/DDR1/COBL/SEMA7A/ITSN2/CYFIP2/CTNNB1 29 GO:1904375 regulation of protein localization to cell periphery 19/1115 125/18722 0.000148785356369916 0.00436464295417023 EGFR/LRP1/DAG1/ITGB1/ATP2B4/HECTD1/SPTBN1/CLTC/ADAM10/DLG1/KIF5B/PRKCI/LYPLA1/SORBS1/PPFIA1/CLN3/ACSL3/APPL1/ACTB 19 GO:0007249 I-kappaB kinase/NF-kappaB signaling 33/1115 281/18722 0.000152456479269372 0.00443145283130765 GAPDH/WLS/HACD3/ASH1L/CD74/GJA1/BRD4/SLC44A2/PRDX4/AKAP13/GSTP1/ROCK1/UFL1/TFRC/TMED4/MIER1/HSPB1/DHX36/CANT1/ZDHHC17/CFLAR/TAB2/REL/TLR3/TRIM38/ANKRD17/MAVS/USP10/EEF1D/TRIM13/CTNNB1/LTBR/RHOA 33 GO:0007043 cell-cell junction assembly 21/1115 146/18722 0.000152722854647051 0.00443145283130765 ACTG1/GJA1/CTNND1/MYO1C/PKN2/DLG5/DLG1/MPP7/ROCK1/FZD5/GJA5/TRPV4/F11R/CLDN4/PKP2/CAV1/RAB13/ACTB/OCLN/CTNNB1/RHOA 21 GO:0042176 regulation of protein catabolic process 42/1115 391/18722 0.000158473861774159 0.00455012250924583 EGFR/LRP2/LRP1/CDH1/EEF1A1/RPL23/RPL5/MYCBP2/CTSC/OAZ1/GJA1/RNF128/HECTD1/FURIN/HSP90AB1/USP25/GNA12/MDM4/DDB1/RNF217/ROCK1/UFL1/WWP1/ZYG11B/SMARCC1/TMEM259/PIAS1/CTSA/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/ANXA2/SMURF2/GPC3/EIF3H/RHBDF1/CDC20/HSPA1A/ATRAID 42 GO:0003158 endothelium development 20/1115 136/18722 0.000160061764955496 0.00455012250924583 MET/FSTL1/NRP1/GJA1/JAG1/ROCK1/GJA5/NR2F2/RBPJ/F11R/BMPR2/FOXP1/S1PR2/S1PR3/ZDHHC21/ACVR2B/RAPGEF2/CTNNB1/FASN/RHOA 20 GO:0007492 endoderm development 14/1115 77/18722 0.000160793349780607 0.00455012250924583 COL4A2/LAMC1/LAMB1/ITGAV/ITGB5/ZFP36L1/BPTF/FN1/COL5A2/MMP15/SMAD2/SETD2/BMPR1A/CTNNB1 14 GO:0055117 regulation of cardiac muscle contraction 14/1115 77/18722 0.000160793349780607 0.00455012250924583 AKAP9/DSC2/CALM1/DSG2/P2RX4/SLC9A1/DLG1/ATP2A2/GJA5/DMD/ATP1A1/DSP/PKP2/CAV1 14 GO:0060411 cardiac septum morphogenesis 13/1115 68/18722 0.000161808574040989 0.00455012250924583 LRP2/NRP2/NRP1/TGFBR3/BMP7/JAG1/TGFBR1/RBPJ/BMPR2/BMPR1A/FGFR2/DHRS3/ISL1 13 GO:0033674 positive regulation of kinase activity 48/1115 467/18722 0.000161926067944692 0.00455012250924583 EGFR/DAG1/MET/IQGAP1/FLT1/IGF1R/NPM1/PRLR/ATP2B4/CD74/PPIA/CALM1/ERBB3/MAGED1/RPS3/HSP90AB1/RANBP2/VLDLR/TAOK1/DLG1/AKAP13/RYK/FZD5/RICTOR/EPHB4/PPP1R9A/DVL3/ADAM17/WNK1/BMPR2/DDR1/TAOK3/VAV3/HMGB1/OSBPL8/PDGFD/CCND1/TAB2/BMPR1A/INSR/PKD2/EFNA5/TLR3/FGFR2/CKS1B/ERBB2/RAPGEF2/RHOA 48 GO:0030038 contractile actin filament bundle assembly 17/1115 106/18722 0.000168374756461063 0.00465778665671304 MET/PFN1/NRP1/ITGB5/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/SORBS1/PPFIA1/S100A10/F11R/RHOA/WASF2 17 GO:0043149 stress fiber assembly 17/1115 106/18722 0.000168374756461063 0.00465778665671304 MET/PFN1/NRP1/ITGB5/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/SORBS1/PPFIA1/S100A10/F11R/RHOA/WASF2 17 GO:1905477 positive regulation of protein localization to membrane 17/1115 106/18722 0.000168374756461063 0.00465778665671304 EGFR/LRP1/TCAF1/ITGB1/ATP2B4/SLC5A3/ANK3/SPTBN1/MYO1C/DLG1/KIF5B/PRKCI/SORBS1/CLN3/ACSL3/STOM/ERBB2 17 GO:0048762 mesenchymal cell differentiation 29/1115 236/18722 0.000172311394503164 0.00471824754262053 LAMA5/DAG1/NRP2/SEMA6D/NRP1/SEMA6A/RTN4/SEMA3F/TGFBR3/GCNT2/DDX17/BMP7/DLG5/FOLR1/FN1/JAG1/ROCK1/TGFBR1/TCF7L2/SEMA4B/RBPJ/SMAD2/SEMA7A/EDNRB/PHACTR4/BMPR1A/FGFR2/ISL1/CTNNB1 29 GO:0071214 cellular response to abiotic stimulus 37/1115 331/18722 0.000173211559908901 0.00471824754262053 EGFR/DAG1/MME/SLC2A1/NPM1/NIPBL/SLC38A2/ZFP36L1/GJA1/PLEC/TMEM150C/ADIRF/USP47/RPL26/SLC9A1/DDB1/NET1/MAP3K2/HSPA5/SMPD1/ATP1A1/TRPV4/F11R/DHX36/CLN3/PTPRK/MAPK14/OPN3/PKD2/ITGB6/TLR3/REST/CREBBP/ATM/EEF1D/LTBR/YBX3 37 GO:0104004 cellular response to environmental stimulus 37/1115 331/18722 0.000173211559908901 0.00471824754262053 EGFR/DAG1/MME/SLC2A1/NPM1/NIPBL/SLC38A2/ZFP36L1/GJA1/PLEC/TMEM150C/ADIRF/USP47/RPL26/SLC9A1/DDB1/NET1/MAP3K2/HSPA5/SMPD1/ATP1A1/TRPV4/F11R/DHX36/CLN3/PTPRK/MAPK14/OPN3/PKD2/ITGB6/TLR3/REST/CREBBP/ATM/EEF1D/LTBR/YBX3 37 GO:0007266 Rho protein signal transduction 20/1115 137/18722 0.000177136468296652 0.00472591157111114 ADGRG1/MET/ITGB1/KANK1/NRP1/HACD3/ABCA1/ARHGAP5/CFL1/GNA12/NET1/AKAP13/RHOV/ROCK1/ARHGAP29/F11R/PHACTR4/CCDC125/RHOA/CDC42SE1 20 GO:0050684 regulation of mRNA processing 20/1115 137/18722 0.000177136468296652 0.00472591157111114 HNRNPA1/SON/NPM1/MBNL3/MBNL2/ZFP36L1/RBM25/DDX17/SF1/RBM5/SRSF3/MBNL1/AHCYL1/CELF1/DHX36/TRA2B/REST/NCL/SAP18/SRSF9 20 GO:0090090 negative regulation of canonical Wnt signaling pathway 20/1115 137/18722 0.000177136468296652 0.00472591157111114 ZNRF3/CTNND1/TCF7L2/FERMT1/TPBG/AMFR/SCYL2/SIAH2/LATS2/RBMS3/TMEM64/GLI3/TLE4/JADE1/FZD6/MAPK14/CAV1/CSNK1A1/ISL1/GPC3 20 GO:0007033 vacuole organization 24/1115 180/18722 0.000177889428177376 0.00472591157111114 GRN/ABCA1/GAA/HEXB/RB1CC1/MAN2A1/SCARB2/ATP2A2/SYT7/GNPTAB/TMEM106B/CLN5/TPP1/HOOK2/C9orf72/TMEM41B/MYO7A/NAGLU/RAB3GAP1/CLN3/RAB3GAP2/ATG9A/ANXA2/VMP1 24 GO:0016485 protein processing 28/1115 225/18722 0.000178721550985437 0.00472591157111114 MME/GLG1/CPD/LGMN/ASPH/ENPEP/FURIN/YME1L1/ADAM10/ENO1/CPM/SPCS3/CLN5/PCSK7/NCSTN/ADAM17/GLI3/DDI2/TMEM208/DHCR24/CLN3/PRSS12/CAST/PISD/XIAP/HM13/LPCAT3/CYFIP2 28 GO:2001233 regulation of apoptotic signaling pathway 39/1115 356/18722 0.000178803921589146 0.00472591157111114 TPT1/ITGA6/ITGAV/NRP1/MIF/CTSC/CD74/PPIA/MAGED1/RPS3/USP47/BIRC6/RPL26/RB1CC1/ENO1/GSTP1/GRINA/PHIP/SERINC3/TGFBR1/TCF7L2/P4HB/IFI6/PDIA3/SIAH2/HSPB1/RRM2B/CFLAR/CAV1/SLC35F6/FEM1B/DNAJA1/EIF5A/CTNNB1/HSPA1A/WFS1/LTBR/SOD1/YBX3 39 GO:0045669 positive regulation of osteoblast differentiation 13/1115 69/18722 0.000188653795687888 0.00495989613215767 FBN2/IL6ST/LRP5/BMP7/ATP6AP1/JAG1/SUCO/GLI3/BMPR2/BMPR1A/ACVR2B/CTNNB1/ATRAID 13 GO:0010631 epithelial cell migration 39/1115 357/18722 0.000189514667720578 0.00495989613215767 MET/ITGB1/NRP2/GRN/ANXA1/FSTL1/KANK1/PFN1/NRP1/LGMN/S100P/MACF1/ATP2B4/RTN4/DPP4/PLPP3/NF1/SERPINF1/P2RX4/PKN2/ROCK1/TGFBR1/EPHB4/FERMT1/NR2F2/AMOT/ADAM17/PTPRM/BMPR2/TMSB4X/MIA3/HSPB1/FOXP1/EMC10/AKT3/HMGB1/RAB13/CAPN7/RHOA 39 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 30/1115 249/18722 0.000190718666235439 0.00496705833673664 GAPDH/WLS/ASH1L/CD74/GJA1/BRD4/SLC44A2/AKAP13/GSTP1/UFL1/TFRC/TMED4/MIER1/HSPB1/DHX36/CANT1/ZDHHC17/CFLAR/TAB2/REL/TLR3/TRIM38/ANKRD17/MAVS/USP10/EEF1D/TRIM13/CTNNB1/LTBR/RHOA 30 GO:1905039 carboxylic acid transmembrane transport 21/1115 149/18722 0.000203990976807212 0.00527006315951219 LRP2/ITGB1/SLC2A1/SLC19A1/SLC38A2/SLC43A2/SLC1A5/SLC38A10/ARL6IP5/SLC5A6/SLC38A9/FOLR1/SLC7A6/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC13A3/CPT2/ABCD3/SLC16A2 21 GO:0001952 regulation of cell-matrix adhesion 19/1115 128/18722 0.000204327228698075 0.00527006315951219 LRP1/DAG1/UTRN/CDK6/IQGAP1/NRP1/MACF1/ACTG1/NF1/RASA1/SLC9A1/JAG1/PTPRA/ROCK1/FERMT1/S100A10/DDR1/EFNA5/RHOA 19 GO:0061337 cardiac conduction 16/1115 98/18722 0.000209767453314431 0.00533558435872845 AKAP9/ATP2B1/DSC2/ATP2B4/GJA1/CALM1/DSG2/YWHAE/SLC9A1/ATP2A2/GJA5/ATP1A1/DSP/PKP2/CAV1/ISL1 16 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 6/1115 16/18722 0.000210053978312045 0.00533558435872845 ANK3/SLC9A1/ACTN4/KIF5B/DMD/WNK1 6 GO:0030203 glycosaminoglycan metabolic process 18/1115 118/18722 0.00021019317370714 0.00533558435872845 ITIH5/CHPF/GNS/HS6ST2/GLB1/GCNT2/HEXB/CLTC/HEXA/DSE/B3GNT2/CHST11/GUSB/FUCA1/B3GNT3/NAGLU/CHST14/B3GAT3 18 GO:0061138 morphogenesis of a branching epithelium 24/1115 182/18722 0.00021086501211682 0.00533558435872845 LAMA5/SPINT1/DAG1/MET/LRP5/LGR4/NRP1/PBX1/COL4A1/MAGED1/BMP7/PLXNA1/DLG5/ST14/DLG1/FZD5/GLI3/BTBD7/DDR1/FEM1B/PKD2/FGFR2/GPC3/CTNNB1 24 GO:1903825 organic acid transmembrane transport 21/1115 150/18722 0.000224163212882979 0.00564471162130855 LRP2/ITGB1/SLC2A1/SLC19A1/SLC38A2/SLC43A2/SLC1A5/SLC38A10/ARL6IP5/SLC5A6/SLC38A9/FOLR1/SLC7A6/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC13A3/CPT2/ABCD3/SLC16A2 21 GO:0090132 epithelium migration 39/1115 360/18722 0.000225196399201858 0.00564471162130855 MET/ITGB1/NRP2/GRN/ANXA1/FSTL1/KANK1/PFN1/NRP1/LGMN/S100P/MACF1/ATP2B4/RTN4/DPP4/PLPP3/NF1/SERPINF1/P2RX4/PKN2/ROCK1/TGFBR1/EPHB4/FERMT1/NR2F2/AMOT/ADAM17/PTPRM/BMPR2/TMSB4X/MIA3/HSPB1/FOXP1/EMC10/AKT3/HMGB1/RAB13/CAPN7/RHOA 39 GO:0006022 aminoglycan metabolic process 19/1115 129/18722 0.00022650268698089 0.00565092451304193 ITIH5/CHPF/GNS/HS6ST2/GLB1/GCNT2/HEXB/CLTC/HEXA/DSE/B4GALT5/B3GNT2/CHST11/GUSB/FUCA1/B3GNT3/NAGLU/CHST14/B3GAT3 19 GO:0043087 regulation of GTPase activity 38/1115 348/18722 0.000229782486509055 0.005706086955683 ITGA6/MET/ITGB1/IQGAP2/IQGAP1/ADRB1/PLXNB1/NF1/DOCK8/SNX13/CDKL5/PLXNB2/RASA1/PLXNA1/ARFGEF1/SNX18/NET1/RICTOR/DOCK9/GAPVD1/AMOT/DVL3/EVI5/ARHGAP29/CCPG1/WNK1/S100A10/F11R/RAB3GAP1/VAV3/RAB3GAP2/ASAP1/EFNA5/CCDC125/TBC1D2B/ERBB2/RAPGEF2/SOD1 38 GO:0030177 positive regulation of Wnt signaling pathway 20/1115 140/18722 0.000238346402484188 0.00587670507647688 EGFR/LGR5/KANK1/LGR4/WLS/MACF1/TBL1X/USP47/UBR5/USP34/TNKS2/RBPJ/TBL1XR1/WNK1/CAV1/XIAP/FGFR2/SMURF2/PTK7/GPC3 20 GO:0032868 response to insulin 31/1115 264/18722 0.000238854654728504 0.00587670507647688 ATP2B1/SLC2A1/KANK1/IGF1R/ZFP36L1/PRKDC/MYO1C/USO1/VPS13C/SLC9A1/GSTP1/PHIP/PTPRA/GAB1/DENND4C/PRKCI/SMARCC1/EPM2AIP1/SORBS1/TRPV4/SOGA1/OSBPL8/CFLAR/RAB13/APPL1/RAB31/SLC2A8/INSR/CAT/GGH/FOXO4 31 GO:0120193 tight junction organization 14/1115 80/18722 0.000244435621314945 0.00598643019358024 SVEP1/ACTG1/GJA1/PLEC/MYO1C/DLG1/MPP7/ROCK1/TGFBR1/FZD5/F11R/CLDN4/RAB13/OCLN 14 GO:0048846 axon extension involved in axon guidance 9/1115 37/18722 0.000249134411274696 0.00604603918998002 NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/RYK/SEMA4B/BMPR2/SEMA7A 9 GO:1902284 neuron projection extension involved in neuron projection guidance 9/1115 37/18722 0.000249134411274696 0.00604603918998002 NRP2/SEMA6D/NRP1/SEMA6A/SEMA3F/RYK/SEMA4B/BMPR2/SEMA7A 9 GO:0071679 commissural neuron axon guidance 5/1115 11/18722 0.000253520306913415 0.00610593181453134 DAG1/NRP1/RYK/NFIB/FZD3 5 GO:0030850 prostate gland development 10/1115 45/18722 0.000253889654022468 0.00610593181453134 ANXA1/PSAP/SERPINF1/BMP7/SMARCC1/GLI3/FEM1B/FGFR2/PLAG1/CTNNB1 10 GO:0034109 homotypic cell-cell adhesion 15/1115 90/18722 0.000259705134846422 0.00621778347508989 IL6ST/DSC2/ACTG1/PLPP3/PPIA/ANK3/DSG2/MYL12A/FN1/F11R/HSPB1/DSP/C1QTNF1/PKP2/ACTB 15 GO:0110020 regulation of actomyosin structure organization 16/1115 100/18722 0.000266385463606245 0.00634008200839425 MET/PFN1/NRP1/ACTG1/SLC9A1/AKAP13/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/PPFIA1/S100A10/F11R/RHOA/WASF2 16 GO:0051235 maintenance of location 36/1115 326/18722 0.000267188322136862 0.00634008200839425 FBN1/FBN2/AKAP9/FTH1/ITGAV/PLIN2/ABCA1/HSP90B1/GAA/SCIN/GJA1/CALM1/LTBP1/HEXB/ANK3/ARHGAP21/CDS1/ITPR2/MCOLN3/VPS13C/MEST/GM2A/SLC30A7/GPAA1/VPS13A/HSPA5/DMD/TMSB4X/OSBPL8/CAV1/SREBF2/PKD2/SKP1/IBTK/ATP7B/FTL 36 GO:0050808 synapse organization 44/1115 426/18722 0.000268455860296229 0.00634197273505117 DAG1/CDH1/NRP2/PTPRF/PFN1/NRP1/IGF1R/LGMN/APP/ACTG1/CFL1/COL4A1/PLXNB1/SEMA3F/ANK3/NRCAM/CDKL5/PLXNB2/ADAM10/DLG5/DLG1/RYK/FZD5/CLSTN1/PPP1R9A/TPBG/PPFIA1/MYH10/WASL/DHX36/CLN3/MAPK14/CAST/OBSL1/ACTB/INSR/ABI2/REST/ERBB2/CTNNB1/CDC20/ARF4/RHOA/WASF2 44 GO:0000723 telomere maintenance 19/1115 131/18722 0.000277245595120575 0.00652076754338657 HNRNPA1/ATRX/PRKDC/PTGES3/HSP90AB1/SMG1/RIF1/TNKS2/PKIB/XRN1/DHX36/DCP2/HNRNPA2B1/YLPM1/HNRNPC/ATM/CTNNB1/HNRNPD/CCT3 19 GO:0048545 response to steroid hormone 37/1115 339/18722 0.000278629014211341 0.00652456274944891 EGFR/ATP2B1/ANXA1/AGL/ZFP36L1/CALM1/TFPI/GLB1/SERPINF1/DDX17/BMP7/PTGES3/NR3C1/ESRRG/UBR5/NCOR1/GSTP1/UFL1/ARID1A/UBE2L3/NPC1/SKP2/ATP1A1/FOXP1/CLDN4/HMGB1/NCOA2/PAQR7/CFLAR/CAV1/CCND1/RPL27/REST/IDH1/ISL1/DNAJA1/RHOA 37 GO:0001704 formation of primary germ layer 18/1115 121/18722 0.000289213621550198 0.00667535356252198 COL4A2/LAMB1/ITGB1/ITGB4/ITGAV/WLS/ITGB5/GJA1/BMP7/FN1/COL5A2/MMP15/BMPR2/SMAD2/SETD2/BMPR1A/FGFR2/CTNNB1 18 GO:0001838 embryonic epithelial tube formation 18/1115 121/18722 0.000289213621550198 0.00667535356252198 LRP2/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/MIB1/SETD2/FZD6/COBL/PHACTR4/FZD3/PTK7/CTNNB1/IRX2 18 GO:0002064 epithelial cell development 27/1115 220/18722 0.000290069680933714 0.00667535356252198 ADAMTSL4/IL6ST/MET/CDK6/IQGAP1/ATRX/EXPH5/PLEC/B4GALT1/ST14/JAG1/ROCK1/PALLD/FAT1/F11R/MYO7A/TFCP2L1/S1PR2/RAB13/S1PR3/ZDHHC21/FEM1B/ABI2/RAPGEF2/FASN/GPAT4/SOD1 27 GO:0044706 multi-multicellular organism process 27/1115 220/18722 0.000290069680933714 0.00667535356252198 ITGB4/SLC2A1/STS/PRLR/FBLN1/SLC6A4/SLC19A1/SLC38A2/ASH1L/GJA1/CTSB/HEXB/B4GALT1/LNPEP/SLC38A1/ADCY7/NR2F2/BMPR2/DDR1/CLDN4/AGO2/MAGED2/SMURF2/VMP1/PRDX3/SOD1/HPGD 27 GO:1903036 positive regulation of response to wounding 13/1115 72/18722 0.000293269987145855 0.00671104334692832 LRP1/ITGB1/GRN/ANXA1/KANK1/ACTG1/PLPP3/ANO6/ARFGEF1/FERMT1/CLDN4/HMGB1/OCLN 13 GO:0051492 regulation of stress fiber assembly 15/1115 91/18722 0.000294134508930741 0.00671104334692832 MET/PFN1/NRP1/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/PPFIA1/S100A10/F11R/RHOA/WASF2 15 GO:0090130 tissue migration 39/1115 365/18722 0.000298228590243491 0.00677549975876595 MET/ITGB1/NRP2/GRN/ANXA1/FSTL1/KANK1/PFN1/NRP1/LGMN/S100P/MACF1/ATP2B4/RTN4/DPP4/PLPP3/NF1/SERPINF1/P2RX4/PKN2/ROCK1/TGFBR1/EPHB4/FERMT1/NR2F2/AMOT/ADAM17/PTPRM/BMPR2/TMSB4X/MIA3/HSPB1/FOXP1/EMC10/AKT3/HMGB1/RAB13/CAPN7/RHOA 39 GO:1902905 positive regulation of supramolecular fiber organization 26/1115 209/18722 0.000301008755043271 0.00680968535244078 AKAP9/MET/PFN1/IQGAP2/NRP1/CLIP1/APP/SCIN/RPS3/MYO1C/DLG1/CD47/TGFBR1/RICTOR/NCKAP1/MTSS1/S100A10/TRPV4/WASL/ARPC3/ABI2/OCLN/HSPA1A/RHOA/WASF2/DSTN 26 GO:0072175 epithelial tube formation 19/1115 132/18722 0.000306145438886056 0.006836165814108 LRP2/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/MIB1/SETD2/FZD6/COBL/PHACTR4/FGFR2/FZD3/PTK7/CTNNB1/IRX2 19 GO:0006984 ER-nucleus signaling pathway 10/1115 46/18722 0.000307300954370841 0.006836165814108 ATF6/ATP2A2/HSPA5/AMFR/TMEM33/CCDC47/PPP1R15B/SREBF2/LPCAT3/WFS1 10 GO:0050919 negative chemotaxis 10/1115 46/18722 0.000307300954370841 0.006836165814108 NRP2/SEMA6D/ITGAV/SEMA6A/DPP4/SEMA3F/RYK/SEMA4B/SEMA7A/RHOA 10 GO:0055010 ventricular cardiac muscle tissue morphogenesis 10/1115 46/18722 0.000307300954370841 0.006836165814108 LRP2/TGFBR3/TGFBR1/RBPJ/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1 10 GO:0010810 regulation of cell-substrate adhesion 27/1115 221/18722 0.000312142896901329 0.00691506608529541 ITGA6/LRP1/DAG1/KANK1/UTRN/CDK6/IQGAP1/NRP1/FBLN1/MACF1/ACTG1/NF1/GCNT2/RASA1/CCDC80/SLC9A1/ACTN4/FN1/JAG1/PTPRA/ROCK1/P4HB/FERMT1/S100A10/DDR1/EFNA5/RHOA 27 GO:0030900 forebrain development 40/1115 379/18722 0.000323416461478144 0.00713058094333582 LRP2/LRP1/CDH1/ADGRG1/LAMB1/NRP2/SLC2A1/CDK6/NRP1/APP/ATP2B4/RTN4/SLC38A2/ATRX/PGAP1/NF1/TACC2/PCM1/RYK/KIF5B/TOP2B/NR2F2/SCYL2/RBPJ/NFIB/GLI3/RAB3GAP1/CELF1/SETD2/SEMA7A/TSKU/BMPR1A/TRA2B/FGFR2/ISL1/UBA6/C21orf91/RAPGEF2/CTNNB1/RHOA 40 GO:0031396 regulation of protein ubiquitination 26/1115 210/18722 0.000324542268070913 0.00713058094333582 RPS20/RPL23/NPM1/RPL5/MYCBP2/RPS2/PPIA/RPS3/HSP90AB1/UBR5/UFL1/TGFBR1/HSPA5/UBE2L3/TRIM44/TRIP12/SKP2/SIAH2/CAV1/XIAP/SKP1/DNAJA1/UBE2C/CDC20/HSPA1A/WFS1 26 GO:0006814 sodium ion transport 29/1115 245/18722 0.000326821805938059 0.00715123615534137 UTRN/SLC13A4/SLC6A4/ATP2B4/SLC38A2/PRSS8/SLC5A3/ANO6/ANK3/SLC38A10/P2RX4/ATP6V1B1/SLC5A6/SLC9A1/DLG1/ACTN4/SLC22A5/KIF5B/SLC38A1/AHCYL1/GPD1L/DMD/ATP1A1/SLC13A3/WNK1/PKP2/STOM/PKD2/MAGED2 29 GO:0001841 neural tube formation 16/1115 102/18722 0.00033576802838039 0.00727260760431339 LRP2/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/MIB1/SETD2/FZD6/COBL/PHACTR4/FZD3/PTK7 16 GO:0086003 cardiac muscle cell contraction 13/1115 73/18722 0.000337661790724758 0.00727260760431339 AKAP9/DSC2/GJA1/DSG2/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/ATP1A1/DSP/PKP2/CAV1 13 GO:0003229 ventricular cardiac muscle tissue development 11/1115 55/18722 0.000337817322695209 0.00727260760431339 LRP2/TGFBR3/DSG2/TGFBR1/RBPJ/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1 11 GO:0098900 regulation of action potential 11/1115 55/18722 0.000337817322695209 0.00727260760431339 AKAP9/DSC2/CALM1/DSG2/SLC9A1/DLG1/ATP2A2/GJA5/DSP/PKP2/CAV1 11 GO:0003007 heart morphogenesis 29/1115 246/18722 0.000349946635845779 0.00750347425213099 LRP2/NRP2/NRP1/RTN4/GAA/NIPBL/TGFBR3/BMP7/MDM4/FOLR1/JAG1/ADAMTS1/TGFBR1/EPHB4/GJA5/RBPJ/BMPR2/MIB1/DSP/LY6E/AHI1/PKP2/BMPR1A/INSR/PKD2/FGFR2/DHRS3/ISL1/CTNNB1 29 GO:0071902 positive regulation of protein serine/threonine kinase activity 25/1115 200/18722 0.00036223402392358 0.00773586981491198 EGFR/IQGAP1/FLT1/ATP2B4/CALM1/MAGED1/RPS3/HSP90AB1/TAOK1/AKAP13/FZD5/RICTOR/DVL3/ADAM17/BMPR2/TAOK3/PDGFD/CCND1/BMPR1A/INSR/PKD2/CKS1B/ERBB2/RAPGEF2/RHOA 25 GO:0003148 outflow tract septum morphogenesis 7/1115 24/18722 0.000368140192667528 0.00780328239906855 LRP2/NRP2/NRP1/BMPR2/BMPR1A/FGFR2/ISL1 7 GO:0048483 autonomic nervous system development 10/1115 47/18722 0.000369775322525631 0.00780328239906855 NRP2/NRP1/NF1/SEMA3F/FN1/EDNRB/PHACTR4/FZD3/NAV2/CTNNB1 10 GO:0072583 clathrin-dependent endocytosis 10/1115 47/18722 0.000369775322525631 0.00780328239906855 CANX/AAK1/CLTC/LMBRD1/SCYL2/WASL/CLTA/DNAJC6/AP2A2/ITSN2 10 GO:0045927 positive regulation of growth 30/1115 259/18722 0.000377586398799995 0.00793674717792588 EGFR/LRP1/CSH1/GOLGA4/NRP1/MACF1/NIPBL/TGFBR3/PRKDC/CDKL5/ADAM10/USP47/SLC9A1/FN1/TGFBR1/RBPJ/ADAM17/BMPR2/CELF1/TFCP2L1/SEMA7A/MAPK14/BMPR1A/ITSN2/INSR/FGFR2/ERBB2/WFS1/RHOA/YBX3 30 GO:0046326 positive regulation of glucose import 9/1115 39/18722 0.000381160845602133 0.00798046178301878 PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/INSR/OCLN/GPC3 9 GO:2001234 negative regulation of apoptotic signaling pathway 27/1115 224/18722 0.000387529897849564 0.00805310635489572 TPT1/ITGA6/ITGAV/NRP1/MIF/CD74/PPIA/USP47/BIRC6/RB1CC1/ENO1/GSTP1/GRINA/PHIP/TGFBR1/TCF7L2/IFI6/SIAH2/HSPB1/RRM2B/CFLAR/SLC35F6/DNAJA1/CTNNB1/HSPA1A/WFS1/YBX3 27 GO:0070972 protein localization to endoplasmic reticulum 13/1115 74/18722 0.000387647187339989 0.00805310635489572 SEC62/RTN4/GJA1/SEC63/SEC61A1/SPCS3/GPAA1/HSPA5/TRAM1/MIA3/RAB3GAP1/RAB3GAP2/TRAM2 13 GO:0030166 proteoglycan biosynthetic process 11/1115 56/18722 0.000398083535179438 0.00820605403213521 CHPF/EXTL2/HS6ST2/DSE/TCF7L2/CHST11/BMPR2/CHST14/CANT1/B3GAT3/CTNNB1 11 GO:0071385 cellular response to glucocorticoid stimulus 11/1115 56/18722 0.000398083535179438 0.00820605403213521 EGFR/ATP2B1/ANXA1/ZFP36L1/SERPINF1/NR3C1/GSTP1/UBE2L3/CFLAR/REST/ISL1 11 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 5/1115 12/18722 0.000413318525596852 0.00848733695446767 NRP1/PLXNB1/SEMA3F/PLXNB2/PLXNA1 5 GO:0048813 dendrite morphogenesis 20/1115 146/18722 0.000418319292809511 0.00855711380961679 ITGB1/NRP1/CFL1/CUX1/CDKL5/ADAM10/SLC11A2/VLDLR/KIDINS220/TMEM106B/PPP1R9A/TPBG/WASL/DHX36/TRAK2/OBSL1/PPP3CA/ABI2/RERE/RAPGEF2 20 GO:0014020 primary neural tube formation 15/1115 94/18722 0.000421983068408502 0.00856641673852848 LRP2/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/SETD2/FZD6/COBL/PHACTR4/FZD3/PTK7 15 GO:0061326 renal tubule development 15/1115 94/18722 0.000421983068408502 0.00856641673852848 LAMA5/LGR5/LGR4/PBX1/COL4A1/MAGED1/DLG1/JAG1/MTSS1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 15 GO:0046942 carboxylic acid transport 31/1115 273/18722 0.000429819664681244 0.00869245147626198 LRP2/SLC26A2/ITGB1/ANXA1/PSAP/SLC19A1/SLC38A2/SLC43A2/GJA1/SLC16A12/SLC1A5/SLC17A5/ARL6IP5/P2RX4/SLC5A6/SLC16A4/SLC38A9/FOLR1/SLC7A6/SERINC3/SLC35D1/SLC16A1/SLC38A1/SLC7A2/SLC1A3/SLC13A3/RAB3GAP1/CLN3/ABCD3/SLC16A2/PLA2R1 31 GO:0036507 protein demannosylation 6/1115 18/18722 0.000439290311339872 0.00881718410617886 EDEM3/MAN1A2/AMFR/MAN1C1/TRIM13/MAN1B1 6 GO:0036508 protein alpha-1,2-demannosylation 6/1115 18/18722 0.000439290311339872 0.00881718410617886 EDEM3/MAN1A2/AMFR/MAN1C1/TRIM13/MAN1B1 6 GO:0007435 salivary gland morphogenesis 8/1115 32/18722 0.000449441936381237 0.00892033642505361 LAMA5/DAG1/NRP1/BMP7/PLXNA1/NFIB/BTBD7/FGFR2 8 GO:0035767 endothelial cell chemotaxis 8/1115 32/18722 0.000449441936381237 0.00892033642505361 MET/NRP1/LGMN/P2RX4/TMSB4X/HSPB1/HMGB1/RAB13 8 GO:0048841 regulation of axon extension involved in axon guidance 8/1115 32/18722 0.000449441936381237 0.00892033642505361 SEMA6D/NRP1/SEMA6A/SEMA3F/RYK/SEMA4B/BMPR2/SEMA7A 8 GO:0006869 lipid transport 41/1115 398/18722 0.000451442467519247 0.00892685679290837 LRP1/ANXA1/SLC2A1/ITGAV/ATP10D/PSAP/PLIN2/ABCA1/SLC27A2/ANO6/TMEM30A/FURIN/P2RX4/SGPP1/LRP10/VLDLR/GM2A/SCARB2/SYT7/KCNN4/NPC1/CROT/TTPA/PLEKHA8/C1QTNF1/CLN3/SLC27A6/CPT2/OSBPL8/ABCD3/TSKU/CAV1/ACSL3/SREBF2/LPCAT3/TMEM30B/ANXA2/ATP11B/SPNS1/ESYT2/PLA2R1 41 GO:0032869 cellular response to insulin stimulus 25/1115 203/18722 0.000454079099787069 0.00894586093639543 ATP2B1/KANK1/IGF1R/ZFP36L1/PRKDC/MYO1C/USO1/SLC9A1/GSTP1/PHIP/PTPRA/GAB1/DENND4C/PRKCI/SMARCC1/SORBS1/SOGA1/OSBPL8/CFLAR/RAB13/APPL1/RAB31/SLC2A8/INSR/FOXO4 25 GO:0016331 morphogenesis of embryonic epithelium 20/1115 147/18722 0.000457679972710744 0.00898365211140684 LRP2/LAMA5/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/MIB1/SETD2/FZD6/COBL/PHACTR4/FGFR2/FZD3/PTK7/CTNNB1/IRX2 20 GO:0043001 Golgi to plasma membrane protein transport 9/1115 40/18722 0.000466126909286502 0.00911593981201698 GOLGA4/MACF1/ANK3/SPTBN1/KRT18/LYPLA1/CLN3/ACSL3/RAB31 9 GO:0032231 regulation of actin filament bundle assembly 16/1115 105/18722 0.000468869133932953 0.00913610330681765 MET/PFN1/NRP1/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/MTSS1/PPFIA1/S100A10/F11R/RHOA/WASF2 16 GO:0006942 regulation of striated muscle contraction 15/1115 95/18722 0.000474023400801312 0.0091696048437616 AKAP9/DSC2/CALM1/DSG2/P2RX4/SLC9A1/DLG1/ATP2A2/GJA5/DMD/ATP1A1/TRPV4/DSP/PKP2/CAV1 15 GO:0030516 regulation of axon extension 15/1115 95/18722 0.000474023400801312 0.0091696048437616 LRP1/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/SEMA3F/NRCAM/CDKL5/FN1/RYK/SEMA4B/BMPR2/SEMA7A 15 GO:0098657 import into cell 27/1115 227/18722 0.000478529535343879 0.00922335447364971 LRP2/ITGB1/SLC2A1/SLC27A2/SLC39A10/SLC6A4/ATP2B4/SLC19A1/SLC5A3/SLC43A2/SLC1A5/ARL6IP5/SLC11A2/SLC5A6/SLC9A1/DLG1/FOLR1/SLC38A1/SLC7A2/SLC1A3/ATP1A1/SLC29A1/WNK1/TRPV4/ACSL3/SLC16A2/ACTB 27 GO:0035148 tube formation 20/1115 148/18722 0.00050021851100441 0.00960671449731131 LRP2/SPINT1/PFN1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/NFIB/MIB1/SETD2/FZD6/COBL/PHACTR4/FGFR2/FZD3/PTK7/CTNNB1/IRX2 20 GO:0032386 regulation of intracellular transport 36/1115 337/18722 0.000502512257257468 0.00961617541755421 CDH1/TCAF1/LMAN1/PGAP1/OAZ1/ANK3/TMEM30A/TPR/HSP90AB1/MYO1C/UBR5/YWHAE/ERLEC1/PTPN14/GCC2/PCM1/DYNC1H1/TCF7L2/FZD5/KIF5B/FERMT1/UBE2L3/NPEPPS/REEP5/PPP1R12A/GLI3/SETD2/MAPK14/RAN/SREBF2/STOM/B3GAT3/TMEM30B/ANXA2/MAVS/ERBB2 36 GO:0140115 export across plasma membrane 13/1115 76/18722 0.000506658920008198 0.00964623644411262 ATP2B1/SLC40A1/ABCA1/GJA1/CALM1/ANO6/YWHAE/SLC9A1/DLG1/SLC22A5/ATP1A1/SLC22A18/ATP7B 13 GO:0007565 female pregnancy 24/1115 193/18722 0.000507696654953296 0.00964623644411262 ITGB4/SLC2A1/STS/PRLR/FBLN1/SLC19A1/SLC38A2/ASH1L/GJA1/CTSB/LNPEP/SLC38A1/ADCY7/NR2F2/BMPR2/DDR1/CLDN4/AGO2/MAGED2/SMURF2/VMP1/PRDX3/SOD1/HPGD 24 GO:0070849 response to epidermal growth factor 10/1115 49/18722 0.000526655037205166 0.00997096185687369 EGFR/EEF1A1/IQGAP1/ZFP36L1/TPR/GSTP1/CFLAR/GAREM1/NCL/ERBB2 10 GO:0009896 positive regulation of catabolic process 48/1115 492/18722 0.000533837510376128 0.0100187591888505 LRP2/LRP1/APP/CTSC/ZFP36L1/OAZ1/GJA1/KCNQ1OT1/TNRC6B/RNF128/HECTD1/FURIN/ATF6/DDB1/RNF217/ROCK1/UFL1/VDAC1/WWP1/ZYG11B/CNOT6L/TMEM259/C9orf72/PIAS1/RAB3GAP1/CELF1/DHX36/DCP2/PUM1/AGO2/HMGB1/RAB3GAP2/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/INSR/TRIM38/MOV10/SMURF2/RC3H1/GPC3/TRIM13/CDC20/HSPA1A/HNRNPD 48 GO:0043254 regulation of protein-containing complex assembly 43/1115 427/18722 0.00053425480303336 0.0100187591888505 AKAP9/MET/RPL13A/KANK1/PFN1/IQGAP2/ABCA1/CLIP1/SCIN/RPS3/SPTBN1/MYO1C/RASA1/ADD3/ARFGEF1/DLG1/ARHGAP18/MPP7/SPTAN1/ARHGAP28/TFRC/RICTOR/HSPA5/NCKAP1/FERMT1/PPP1R9A/KANK4/SENP6/TMSB4X/WASL/ARPC3/HMGB1/CAMSAP2/ASAP1/ABI2/ATF7IP/ISL1/CYFIP2/OCLN/ATM/HSPA1A/RHOA/WASF2 43 GO:0030198 extracellular matrix organization 33/1115 301/18722 0.000536685732910888 0.0100187591888505 ADAMTSL4/ADAMTS6/SPINT1/COL4A2/LAMC1/LRP1/DAG1/LAMB1/ITGB1/FBLN1/APP/COL14A1/COL4A1/DPP4/NF1/FURIN/PRDX4/ADAM10/CCDC80/B4GALT1/LTBP3/COL5A2/ADAMTS1/TGFBR1/FERMT1/VWA1/CRTAP/MMP15/DDR1/ADAMTS19/CFLAR/CAV1/ANXA2 33 GO:0042063 gliogenesis 33/1115 301/18722 0.000536685732910888 0.0100187591888505 EGFR/LRP2/SPINT1/LRP1/DAG1/ADGRG1/IL6ST/LAMB1/ITGB4/GRN/ANXA1/CDK6/APP/RTN4/DICER1/NF1/ERBB3/HEXB/PLEC/P2RX4/GPC1/B4GALT5/GSTP1/UFL1/PRKCI/NCSTN/NFIB/GLI3/PLAG1/ERBB2/CTNNB1/RHOA/SOD1 33 GO:0018208 peptidyl-proline modification 11/1115 58/18722 0.00054587528407758 0.0101548018874223 NKTR/PPIA/PRDX4/P3H1/RANBP2/P3H2/P4HB/PPIG/CRTAP/FKBP14/P4HTM 11 GO:0043062 extracellular structure organization 33/1115 302/18722 0.000569021957864435 0.0105486396980494 ADAMTSL4/ADAMTS6/SPINT1/COL4A2/LAMC1/LRP1/DAG1/LAMB1/ITGB1/FBLN1/APP/COL14A1/COL4A1/DPP4/NF1/FURIN/PRDX4/ADAM10/CCDC80/B4GALT1/LTBP3/COL5A2/ADAMTS1/TGFBR1/FERMT1/VWA1/CRTAP/MMP15/DDR1/ADAMTS19/CFLAR/CAV1/ANXA2 33 GO:0000380 alternative mRNA splicing, via spliceosome 13/1115 77/18722 0.00057691286396068 0.0106579161961456 HNRNPA1/MBNL3/MBNL2/RBM25/DDX17/RBM5/MBNL1/CELF1/TRA2B/REST/CDK13/SAP18/SRSF9 13 GO:0048736 appendage development 22/1115 172/18722 0.00058114084919116 0.0106622370922048 FBN2/ITGA6/ITGB4/LRP5/PBX1/NIPBL/ATRX/ZNRF3/BMP7/MBNL1/CHST11/NR2F2/GLI3/BMPR2/FZD6/FRAS1/BMPR1A/FGFR2/FREM2/CREBBP/GPC3/CTNNB1 22 GO:0060173 limb development 22/1115 172/18722 0.00058114084919116 0.0106622370922048 FBN2/ITGA6/ITGB4/LRP5/PBX1/NIPBL/ATRX/ZNRF3/BMP7/MBNL1/CHST11/NR2F2/GLI3/BMPR2/FZD6/FRAS1/BMPR1A/FGFR2/FREM2/CREBBP/GPC3/CTNNB1 22 GO:0006417 regulation of translation 46/1115 468/18722 0.000589133525120402 0.0107718626391021 GAPDH/RPL13A/NPM1/RPL5/APP/ZFP36L1/EIF1/PRKDC/YBX1/TNRC6B/RPS3/TPR/PLXNB2/RPS4X/RPL26/LARP4/ROCK1/NEMF/SECISBP2L/IREB2/RPL38/LRPPRC/CNOT6L/PUM2/CPEB4/LTN1/RPS9/XRN1/DNAJC3/HSPB1/CELF1/DHX36/DCP2/PUM1/AGO2/PPP1R15B/MOV10/EIF5A/NCL/RC3H1/ERBB2/PAIP2/EIF3H/HNRNPD/RHOA/YBX3 46 GO:1903320 regulation of protein modification by small protein conjugation or removal 28/1115 242/18722 0.000592437266097254 0.0107952988521954 RPS20/RPL23/NPM1/RPL5/MYCBP2/RPS2/PPIA/RPS3/HSP90AB1/UBR5/UFL1/TGFBR1/HSPA5/UBE2L3/TRIM44/TRIP12/SKP2/SIAH2/PIAS1/CAV1/XIAP/SKP1/DNAJA1/UBE2C/CTNNB1/CDC20/HSPA1A/WFS1 28 GO:0014909 smooth muscle cell migration 15/1115 97/18722 0.000594719054293346 0.0108000171118101 LRP1/SEMA6D/IQGAP1/NRP1/S100A11/PLXNA1/GNA12/GSTP1/ADAMTS1/DDR1/S1PR2/PDGFD/BMPR1A/FOXO4/RHOA 15 GO:0006491 N-glycan processing 6/1115 19/18722 0.00060987390334749 0.0110376839660076 GANAB/MAN2A1/MAN1A2/GNPTAB/MAN1C1/MAN1B1 6 GO:0016049 cell growth 47/1115 482/18722 0.000613980446745612 0.0110744648823474 EGFR/LRP1/ITGB1/NRP2/SEMA6D/GOLGA4/IQGAP1/NRP1/NPM1/SEMA6A/MACF1/APP/RTN4/SEMA3F/GJA1/SMARCA2/NRCAM/CDKL5/HSP90AB1/KIAA1109/ADAM10/USP47/PLXNA1/ENO1/SLC9A1/NET1/AKAP13/FN1/USP9X/TGFBR1/RYK/SEMA4B/CLSTN1/SERTAD2/C9orf72/ADAM17/BMPR2/DDR1/JADE1/COBL/SEMA7A/ITSN2/CYFIP2/ERBB2/CTNNB1/HSPA1A/RHOA 47 GO:0043542 endothelial cell migration 31/1115 279/18722 0.000622740087523944 0.0111771495891789 MET/ITGB1/NRP2/GRN/ANXA1/FSTL1/NRP1/LGMN/S100P/ATP2B4/DPP4/PLPP3/NF1/SERPINF1/P2RX4/TGFBR1/EPHB4/NR2F2/AMOT/ADAM17/PTPRM/BMPR2/TMSB4X/MIA3/HSPB1/FOXP1/EMC10/AKT3/HMGB1/RAB13/RHOA 31 GO:0002026 regulation of the force of heart contraction 7/1115 26/18722 0.00063014085528055 0.0111771495891789 ADRB1/ATP2B4/GAA/SLC9A1/ATP2A2/ATP1A1/CAV1 7 GO:0006517 protein deglycosylation 7/1115 26/18722 0.00063014085528055 0.0111771495891789 EDEM3/MAN2A1/MAN1A2/AMFR/MAN1C1/TRIM13/MAN1B1 7 GO:0048843 negative regulation of axon extension involved in axon guidance 7/1115 26/18722 0.00063014085528055 0.0111771495891789 SEMA6D/NRP1/SEMA6A/SEMA3F/RYK/SEMA4B/SEMA7A 7 GO:0060669 embryonic placenta morphogenesis 7/1115 26/18722 0.00063014085528055 0.0111771495891789 SPINT1/ZFP36L1/BMP7/ST14/FZD5/SETD2/FGFR2 7 GO:1903362 regulation of cellular protein catabolic process 29/1115 255/18722 0.000632454827111808 0.0111810474236753 LRP2/LRP1/RPL23/RPL5/CTSC/RNF128/HECTD1/FURIN/HSP90AB1/USP25/GNA12/RNF217/UFL1/ZYG11B/SMARCC1/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/ANXA2/EIF3H/RHBDF1/CDC20/HSPA1A/ATRAID 29 GO:0090303 positive regulation of wound healing 11/1115 59/18722 0.000635418274347514 0.011183788913533 ITGB1/ANXA1/KANK1/ACTG1/PLPP3/ANO6/ARFGEF1/FERMT1/CLDN4/HMGB1/OCLN 11 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 5/1115 13/18722 0.000638795434909668 0.011183788913533 BRD4/TCERG1/CDK12/CDK13/CTNNB1 5 GO:0045229 external encapsulating structure organization 33/1115 304/18722 0.000638894103507689 0.011183788913533 ADAMTSL4/ADAMTS6/SPINT1/COL4A2/LAMC1/LRP1/DAG1/LAMB1/ITGB1/FBLN1/APP/COL14A1/COL4A1/DPP4/NF1/FURIN/PRDX4/ADAM10/CCDC80/B4GALT1/LTBP3/COL5A2/ADAMTS1/TGFBR1/FERMT1/VWA1/CRTAP/MMP15/DDR1/ADAMTS19/CFLAR/CAV1/ANXA2 33 GO:0050768 negative regulation of neurogenesis 19/1115 140/18722 0.000648061691003602 0.0113071940139485 SEMA6D/NRP1/SEMA6A/RTN4/DICER1/NF1/SEMA3F/BMP7/PCM1/RYK/SEMA4B/PRTG/SEMA7A/TRAK2/BMPR1A/PPP3CA/REST/RAPGEF2/CTNNB1 19 GO:0043297 apical junction assembly 13/1115 78/18722 0.000655217874818938 0.0113948150933495 GJA1/MYO1C/PKN2/DLG5/DLG1/MPP7/ROCK1/FZD5/F11R/CLDN4/RAB13/OCLN/RHOA 13 GO:0001843 neural tube closure 14/1115 88/18722 0.00066945847569525 0.0116046714342108 LRP2/SPINT1/PFN1/HECTD1/PLXNB2/ST14/FOLR1/DVL3/SETD2/FZD6/COBL/PHACTR4/FZD3/PTK7 14 GO:0030099 myeloid cell differentiation 39/1115 381/18722 0.000694810714178051 0.012005159880248 FBN1/CSF3R/CDK6/ITGB8/RPS6/APP/ZFP36L1/SCIN/CD74/TGFBR3/PRKDC/SLC11A2/TET2/ATP6AP1/JAG1/UFL1/TFRC/IREB2/MEIS2/KLF10/RBPJ/PTBP3/TMEM64/PURB/FOXP1/HMGB1/MAPK14/SH3PXD2A/P4HTM/ITGB6/TLR3/ANXA2/GPC3/CTNNB1/FASN/HSPA1A/LTBR/PRDX3/WASF2 39 GO:0098656 anion transmembrane transport 28/1115 245/18722 0.000719901366384196 0.0123985593391136 LRP2/SLC26A2/TCAF1/ITGB1/SLC13A4/PCYOX1/SLC19A1/GABRE/SLC43A2/GJA1/ANO6/SLC16A12/SLC1A5/ARL6IP5/SLC5A6/SLC38A9/SLC9A1/FOLR1/ANKH/SLC35D1/SLC16A1/SLC4A2/VDAC1/SLC7A2/SLC1A3/SLC35B4/CLCN3/SLC13A3 28 GO:0051604 protein maturation 32/1115 294/18722 0.000731757403539888 0.0125622275803841 MME/GLG1/CPD/LGMN/ASPH/ENPEP/FURIN/PRDX4/YME1L1/ADAM10/ENO1/CPM/SPCS3/CLN5/PCSK7/NCSTN/ADAM17/GLI3/DDI2/TMEM208/DHCR24/CLN3/LMF2/PRSS12/CAST/PISD/XIAP/HM13/LPCAT3/CYFIP2/CREBBP/WFS1 32 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 11/1115 60/18722 0.000736857481906331 0.0126092374868523 HNRNPA1/MBNL3/MBNL2/RBM25/DDX17/RBM5/MBNL1/CELF1/TRA2B/REST/SAP18 11 GO:0048593 camera-type eye morphogenesis 17/1115 120/18722 0.000748473914351482 0.012700625478757 TENM3/LRP5/NF1/BMP7/MAN2A1/JAG1/FZD5/FAT1/PTPRM/GLI3/NAGLU/AHI1/TSKU/PHACTR4/OBSL1/ABI2/CTNNB1 17 GO:0051897 positive regulation of protein kinase B signaling 17/1115 120/18722 0.000748473914351482 0.012700625478757 EGFR/LRP2/MET/ITGB1/IGF1R/RTN4/GCNT2/P2RX4/HSP90AB1/ARFGEF1/TGFBR1/TCF7L2/RICTOR/TPBG/C1QTNF1/OSBPL8/INSR 17 GO:0014910 regulation of smooth muscle cell migration 14/1115 89/18722 0.000751713364166926 0.012700625478757 LRP1/SEMA6D/IQGAP1/NRP1/S100A11/PLXNA1/GNA12/GSTP1/ADAMTS1/S1PR2/PDGFD/BMPR1A/FOXO4/RHOA 14 GO:0060606 tube closure 14/1115 89/18722 0.000751713364166926 0.012700625478757 LRP2/SPINT1/PFN1/HECTD1/PLXNB2/ST14/FOLR1/DVL3/SETD2/FZD6/COBL/PHACTR4/FZD3/PTK7 14 GO:0015931 nucleobase-containing compound transport 26/1115 222/18722 0.000762090176594193 0.0128353295042158 HNRNPA1/NPM1/SLC19A1/ZFP36L1/GJA1/YBX1/TPR/MYO1C/SRSF3/RANBP2/SMG1/SLC28A2/SLC35D1/CD47/THOC2/SLC35B4/LRPPRC/SLC25A36/SLC29A1/SETD2/HNRNPA2B1/RAN/SLC29A3/RANBP17/EIF5A/HNRNPA3 26 GO:0072006 nephron development 19/1115 142/18722 0.000772877874626464 0.0129760848195934 LAMA5/LGR4/IQGAP1/PBX1/ENPEP/MAGED1/BMP7/DLG1/SEC61A1/JAG1/MTSS1/GLI3/PDGFD/AHI1/CFLAR/PKD2/GPC3/CTNNB1/IRX2 19 GO:0010876 lipid localization 44/1115 448/18722 0.000779552688340975 0.0130256643785135 LRP1/ANXA1/SLC2A1/ITGAV/ATP10D/PSAP/PLIN2/ABCA1/SLC27A2/ANO6/HEXB/TMEM30A/FURIN/P2RX4/CDS1/SGPP1/LRP10/MEST/VLDLR/GM2A/SCARB2/SYT7/KCNN4/NPC1/CROT/TTPA/PLEKHA8/C1QTNF1/CLN3/SLC27A6/CPT2/OSBPL8/ABCD3/TSKU/CAV1/ACSL3/SREBF2/LPCAT3/TMEM30B/ANXA2/ATP11B/SPNS1/ESYT2/PLA2R1 44 GO:0072594 establishment of protein localization to organelle 42/1115 422/18722 0.000780710357955479 0.0130256643785135 CDH1/LMAN1/RPL23/SEC62/NIPBL/CALM1/TPR/HSP90AB1/UBR5/VPS13C/RANBP2/TNPO1/SCARB2/SEC63/SEC61A1/GCC2/GNPTAB/SPCS3/FZD5/LAMP2/VPS13A/HSPA5/FERMT1/UBE2L3/NPEPPS/TRAM1/KPNB1/GLI3/RAB3GAP1/IPO7/RAB3GAP2/MAPK14/RAN/SREBF2/APPL1/RANBP17/TRAM2/PPP3CA/DNAJA1/MAVS/IPO9/CCT3 42 GO:0000027 ribosomal large subunit assembly 7/1115 27/18722 0.000807374027113455 0.0134285667624883 RPL23A/RPL3/RPL6/RPLP0/RPL5/RPL24/RPL38 7 GO:0050920 regulation of chemotaxis 26/1115 223/18722 0.000815053894340039 0.0134887484842847 MET/SEMA6D/NRP1/MYCBP2/SEMA6A/LGMN/MIF/DPP4/CD74/SEMA3F/ANO6/P2RX4/ADAM10/GSTP1/RYK/SEMA4B/TPBG/ADAM17/WNK1/TRPV4/BMPR2/TMSB4X/HSPB1/HMGB1/SEMA7A/PDGFD 26 GO:0006509 membrane protein ectodomain proteolysis 9/1115 43/18722 0.000818571737948726 0.0134887484842847 DAG1/SPPL2A/FURIN/ADAM10/ROCK1/NCSTN/ADAM17/SPPL2B/ERAP1 9 GO:0061383 trabecula morphogenesis 9/1115 43/18722 0.000818571737948726 0.0134887484842847 FBN2/PLXNB1/TGFBR3/BMP7/ADAMTS1/TGFBR1/RBPJ/BMPR1A/RHOA 9 GO:0003206 cardiac chamber morphogenesis 17/1115 121/18722 0.000823545308367075 0.0135289489272979 LRP2/NRP2/NRP1/TGFBR3/BMP7/JAG1/ADAMTS1/TGFBR1/RBPJ/BMPR2/DSP/LY6E/PKP2/BMPR1A/FGFR2/DHRS3/ISL1 17 GO:1901264 carbohydrate derivative transport 13/1115 80/18722 0.000838888871537828 0.0136184986700185 PSAP/SLC19A1/GJA1/VLDLR/SLC28A2/SLC35D1/CD47/SLC35B4/SLC29A1/PLEKHA8/CLN3/G6PC3/SLC29A3 13 GO:0045667 regulation of osteoblast differentiation 18/1115 132/18722 0.000839783834046704 0.0136184986700185 FBN2/CRIM1/IL6ST/LRP5/CDK6/BMP7/ATP6AP1/JAG1/SUCO/TMEM64/GLI3/BMPR2/BMPR1A/REST/FGFR2/ACVR2B/CTNNB1/ATRAID 18 GO:0030901 midbrain development 14/1115 90/18722 0.000842346459041759 0.0136184986700185 WLS/DYNLL1/CALM1/YWHAE/DLG5/RYK/HSPA5/FZD6/GNB4/ACTB/FGFR2/FZD3/CTNNB1/RHOA 14 GO:0022613 ribonucleoprotein complex biogenesis 45/1115 463/18722 0.00084936327364617 0.0136184986700185 RPL23A/RPL3/RPL13A/RPL6/RPLP0/RPL7/NPM1/RPS6/RPL5/RPS8/RPS16/DICER1/RPL7A/RPL14/PRKDC/LUC7L3/DDX17/PTGES3/RPS17/SF1/HSP90AB1/RBM5/RPL26/RPL24/RPS21/RPS25/SCAF11/RPSA/RPL10A/SF3B1/RPL38/EIF3A/CELF1/RPL35/AGO2/RAN/RPL27/EIF2S2/ATM/SNRPD2/EIF3H/SNRPF/SNRPD1/SRSF9/SNRPB 45 GO:0071384 cellular response to corticosteroid stimulus 11/1115 61/18722 0.000851383445231868 0.0136184986700185 EGFR/ATP2B1/ANXA1/ZFP36L1/SERPINF1/NR3C1/GSTP1/UBE2L3/CFLAR/REST/ISL1 11 GO:1904356 regulation of telomere maintenance via telomere lengthening 11/1115 61/18722 0.000851383445231868 0.0136184986700185 HNRNPA1/TNKS2/PKIB/XRN1/DHX36/DCP2/HNRNPA2B1/HNRNPC/ATM/CTNNB1/CCT3 11 GO:0048872 homeostasis of number of cells 30/1115 272/18722 0.000852322529746249 0.0136184986700185 ADGRG1/ANXA1/FSTL1/CDK6/LGR4/RPS6/PRDX1/ZFP36L1/CD74/TGFBR3/PRKDC/RPS17/LIPA/SLC11A2/UFL1/IREB2/NCSTN/GCNT4/ADAM17/PTBP3/ZFX/AKT3/HMGB1/MAPK14/LPCAT3/P4HTM/RC3H1/OCIAD2/HSPA1A/SOD1 30 GO:0015695 organic cation transport 8/1115 35/18722 0.000857822362792261 0.0136184986700185 SLC38A2/ATP13A3/SLC44A2/SLC19A3/SLC22A5/SLC44A1/SLC29A1/SLC22A18 8 GO:0035633 maintenance of blood-brain barrier 8/1115 35/18722 0.000857822362792261 0.0136184986700185 LAMC1/ITGB1/ACTG1/GJA1/DMD/F11R/ACTB/OCLN 8 GO:0030324 lung development 22/1115 177/18722 0.00085789339706492 0.0136184986700185 EGFR/LAMA5/DAG1/MME/PTGES3/LIPA/DLG5/MAN2A1/MAN1A2/LTBP3/RBPJ/NFIB/GLI3/BMPR2/SMAD2/HMGB1/BMPR1A/ITGB6/FGFR2/PTK7/GPC3/CTNNB1 22 GO:0021545 cranial nerve development 10/1115 52/18722 0.000862156312130786 0.0136184986700185 NRP2/NRP1/SEMA3F/ERBB3/RPL24/SLC1A3/GLI3/ISL1/NAV2/CTNNB1 10 GO:0032206 positive regulation of telomere maintenance 10/1115 52/18722 0.000862156312130786 0.0136184986700185 HNRNPA1/ATRX/TNKS2/PKIB/DHX36/HNRNPA2B1/ATM/CTNNB1/HNRNPD/CCT3 10 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 10/1115 52/18722 0.000862156312130786 0.0136184986700185 ZNRF3/DAAM1/RYK/DVL3/FZD6/FZD3/SMURF2/PTK7/GPC3/RHOA 10 GO:0045860 positive regulation of protein kinase activity 39/1115 386/18722 0.000890858274607692 0.0140303608499424 EGFR/DAG1/IQGAP1/FLT1/NPM1/PRLR/ATP2B4/PPIA/CALM1/ERBB3/MAGED1/RPS3/HSP90AB1/VLDLR/TAOK1/DLG1/AKAP13/FZD5/RICTOR/PPP1R9A/DVL3/ADAM17/WNK1/BMPR2/TAOK3/HMGB1/OSBPL8/PDGFD/CCND1/TAB2/BMPR1A/INSR/PKD2/EFNA5/TLR3/CKS1B/ERBB2/RAPGEF2/RHOA 39 GO:0006665 sphingolipid metabolic process 20/1115 155/18722 0.0009059814395176 0.014226573251719 PSAP/HACD3/ITGB8/ASAH1/PLPP3/GLB1/SERINC1/HEXB/ORMDL1/SGPP1/HEXA/GM2A/B4GALT5/SERINC3/SMPD1/DEGS1/SPTLC3/TECR/ELOVL1/SERINC2 20 GO:0003281 ventricular septum development 12/1115 71/18722 0.000918766463986678 0.0143850268364366 LRP2/TGFBR3/HECTD1/TRIP11/MDM4/TGFBR1/GJA5/RBPJ/BMPR2/BMPR1A/FGFR2/PTK7 12 GO:0010833 telomere maintenance via telomere lengthening 13/1115 81/18722 0.000945816326711646 0.0147221964090772 HNRNPA1/PTGES3/HSP90AB1/TNKS2/PKIB/XRN1/DHX36/DCP2/HNRNPA2B1/HNRNPC/ATM/CTNNB1/CCT3 13 GO:0071260 cellular response to mechanical stimulus 13/1115 81/18722 0.000945816326711646 0.0147221964090772 EGFR/DAG1/SLC2A1/SLC38A2/GJA1/PLEC/TMEM150C/SLC9A1/MAP3K2/ATP1A1/F11R/TLR3/LTBR 13 GO:0008544 epidermis development 34/1115 324/18722 0.000969635859602136 0.0150490867860924 EGFR/LAMA5/SVEP1/LGR5/ANXA1/LGR4/STS/ASAH1/ZFP36L1/NCOA3/EXPH5/YBX1/PLEC/SGPP1/MCOLN3/ST14/ATP2A2/JAG1/ROCK1/PALLD/FERMT1/RBPJ/MYO7A/DSP/PLOD1/ESRP1/FZD6/OPN3/ZDHHC21/MYO6/FGFR2/FZD3/CTNNB1/SOD1 34 GO:1903078 positive regulation of protein localization to plasma membrane 11/1115 62/18722 0.000980261510762785 0.0151699020462681 EGFR/LRP1/ITGB1/ATP2B4/SPTBN1/DLG1/KIF5B/PRKCI/SORBS1/CLN3/ACSL3 11 GO:0031331 positive regulation of cellular catabolic process 42/1115 427/18722 0.000985505626762832 0.0152005825539329 LRP2/LRP1/APP/CTSC/ZFP36L1/KCNQ1OT1/TNRC6B/RNF128/HECTD1/FURIN/ATF6/RNF217/ROCK1/UFL1/VDAC1/ZYG11B/CNOT6L/TMEM259/C9orf72/PIAS1/RAB3GAP1/CELF1/DHX36/DCP2/PUM1/AGO2/HMGB1/RAB3GAP2/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/INSR/TRIM38/MOV10/RC3H1/TRIM13/CDC20/HSPA1A/HNRNPD 42 GO:0062197 cellular response to chemical stress 35/1115 337/18722 0.000988768803550133 0.0152005825539329 EGFR/MET/ANXA1/SLC2A1/PRDX1/ZFP36L1/PPIA/PLEC/RPS3/BMP7/ARL6IP5/ATP2A2/NET1/P4HB/CHCHD2/TRPV4/HSPB1/CHD6/GPX8/CLN3/NFE2L1/PTPRK/PDGFD/CAV1/OXR1/PKD2/REST/DNAJA1/ATM/CTNNB1/HSPA1A/PLA2R1/PRDX3/SOD1/YBX3 35 GO:0003231 cardiac ventricle development 17/1115 123/18722 0.000993110282733289 0.0152005825539329 LRP2/TGFBR3/HECTD1/TRIP11/MDM4/JAG1/TGFBR1/GJA5/RBPJ/BMPR2/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1/PTK7 17 GO:0051495 positive regulation of cytoskeleton organization 26/1115 226/18722 0.00099363238646237 0.0152005825539329 AKAP9/MET/PFN1/IQGAP2/NRP1/CLIP1/SCIN/RPS3/MYO1C/DLG1/CD47/DYNC1H1/TGFBR1/RICTOR/NCKAP1/MTSS1/S100A10/TRPV4/WASL/ARPC3/ABI2/OCLN/HSPA1A/RHOA/WASF2/DSTN 26 GO:0051961 negative regulation of nervous system development 19/1115 145/18722 0.000998622679410595 0.0152332756724948 SEMA6D/NRP1/SEMA6A/RTN4/DICER1/NF1/SEMA3F/BMP7/PCM1/RYK/SEMA4B/PRTG/SEMA7A/TRAK2/BMPR1A/PPP3CA/REST/RAPGEF2/CTNNB1 19 GO:0033627 cell adhesion mediated by integrin 12/1115 72/18722 0.00104386575935484 0.0158165391701616 FBN1/ITGB1/ITGB4/ITGAV/ITGB8/ITGB5/DPP4/PLPP3/FERMT1/ADAM17/WNK1/ITGB6 12 GO:0035567 non-canonical Wnt signaling pathway 12/1115 72/18722 0.00104386575935484 0.0158165391701616 ZNRF3/DAAM1/RYK/FZD5/DVL3/FZD6/RNF213/FZD3/SMURF2/PTK7/GPC3/RHOA 12 GO:0006643 membrane lipid metabolic process 24/1115 203/18722 0.00104574608111389 0.0158165391701616 PSAP/HACD3/ITGB8/ASAH1/PLPP3/PGAP1/GLB1/SERINC1/HEXB/ORMDL1/SGPP1/HEXA/GM2A/B4GALT5/SERINC3/GPAA1/B3GNT5/SMPD1/DEGS1/FUCA1/SPTLC3/TECR/ELOVL1/SERINC2 24 GO:1905897 regulation of response to endoplasmic reticulum stress 13/1115 82/18722 0.00106391928624668 0.0160007466740029 USP25/ATF6/GRINA/SERINC3/UFL1/HSPA5/TMEM259/TMEM33/CAV1/PPP1R15B/LPCAT3/HSPA1A/WFS1 13 GO:2001252 positive regulation of chromosome organization 13/1115 82/18722 0.00106391928624668 0.0160007466740029 HNRNPA1/ATRX/TPR/MPHOSPH8/TNKS2/PKIB/DHX36/HNRNPA2B1/ATF7IP/ATM/CTNNB1/HNRNPD/CCT3 13 GO:0006913 nucleocytoplasmic transport 32/1115 301/18722 0.00108670013722235 0.0162517984107287 CDH1/HNRNPA1/RPL23/NPM1/TPR/HSP90AB1/UBR5/SRSF3/RANBP2/YWHAE/TNPO1/SMG1/PTPN14/AKAP13/NEMF/TCF7L2/THOC2/FERMT1/AHCYL1/KPNB1/PPP1R12A/GLI3/SETD2/IPO7/HNRNPA2B1/MAPK14/RAN/APPL1/RANBP17/PPP3CA/MAVS/IPO9 32 GO:0051169 nuclear transport 32/1115 301/18722 0.00108670013722235 0.0162517984107287 CDH1/HNRNPA1/RPL23/NPM1/TPR/HSP90AB1/UBR5/SRSF3/RANBP2/YWHAE/TNPO1/SMG1/PTPN14/AKAP13/NEMF/TCF7L2/THOC2/FERMT1/AHCYL1/KPNB1/PPP1R12A/GLI3/SETD2/IPO7/HNRNPA2B1/MAPK14/RAN/APPL1/RANBP17/PPP3CA/MAVS/IPO9 32 GO:0048485 sympathetic nervous system development 6/1115 21/18722 0.00110080644035341 0.0162803478810163 NRP2/NRP1/NF1/SEMA3F/FZD3/CTNNB1 6 GO:0099515 actin filament-based transport 6/1115 21/18722 0.00110080644035341 0.0162803478810163 SYNE2/MYO1C/ACTN4/WASL/MYO7A/MYO6 6 GO:0150105 protein localization to cell-cell junction 6/1115 21/18722 0.00110080644035341 0.0162803478810163 ACTG1/DLG5/MPP7/F11R/DSP/ACTB 6 GO:1902307 positive regulation of sodium ion transmembrane transport 6/1115 21/18722 0.00110080644035341 0.0162803478810163 ANK3/SLC9A1/ACTN4/KIF5B/DMD/WNK1 6 GO:0006937 regulation of muscle contraction 21/1115 169/18722 0.00111613979559349 0.016461520355452 AKAP9/ATP2B1/DSC2/CALM1/DSG2/P2RX4/ENO1/SLC9A1/DLG1/ATP2A2/GJA5/DMD/ATP1A1/TRPV4/DSP/PKP2/CAV1/ZDHHC21/PPP1R12B/RHOA/SOD1 21 GO:0030323 respiratory tube development 22/1115 181/18722 0.00115502438656331 0.0168563720544131 EGFR/LAMA5/DAG1/MME/PTGES3/LIPA/DLG5/MAN2A1/MAN1A2/LTBP3/RBPJ/NFIB/GLI3/BMPR2/SMAD2/HMGB1/BMPR1A/ITGB6/FGFR2/PTK7/GPC3/CTNNB1 22 GO:0035987 endodermal cell differentiation 9/1115 45/18722 0.0011558452205745 0.0168563720544131 COL4A2/LAMB1/ITGAV/ITGB5/FN1/COL5A2/MMP15/SETD2/CTNNB1 9 GO:0071364 cellular response to epidermal growth factor stimulus 9/1115 45/18722 0.0011558452205745 0.0168563720544131 EGFR/EEF1A1/IQGAP1/ZFP36L1/GSTP1/CFLAR/GAREM1/NCL/ERBB2 9 GO:0007041 lysosomal transport 16/1115 114/18722 0.00117029508128244 0.0168563720544131 LRP1/GRN/PSAP/SCARB2/GCC2/GNPTAB/TMEM106B/LAMP2/NPC1/HGSNAT/HOOK2/C9orf72/SCYL2/CLN3/TRAK2/HSPA1A 16 GO:0001706 endoderm formation 10/1115 54/18722 0.001170800004389 0.0168563720544131 COL4A2/LAMB1/ITGAV/ITGB5/FN1/COL5A2/MMP15/SMAD2/SETD2/CTNNB1 10 GO:0070839 metal ion export 10/1115 54/18722 0.001170800004389 0.0168563720544131 ATP2B1/SLC40A1/ATP2B4/CALM1/ANO6/YWHAE/SLC9A1/DLG1/ATP1A1/ATP7B 10 GO:0086002 cardiac muscle cell action potential involved in contraction 10/1115 54/18722 0.001170800004389 0.0168563720544131 DSC2/GJA1/DSG2/DLG1/GJA5/GPD1L/ATP1A1/DSP/PKP2/CAV1 10 GO:0045185 maintenance of protein location 14/1115 93/18722 0.00117132684626096 0.0168563720544131 FBN1/FBN2/SCIN/GJA1/LTBP1/ANK3/VPS13C/GPAA1/VPS13A/HSPA5/TMSB4X/CAV1/PKD2/SKP1 14 GO:0060993 kidney morphogenesis 14/1115 93/18722 0.00117132684626096 0.0168563720544131 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GCNT4/GLI3/FRAS1/AHI1/PKD2/GPC3/CTNNB1/IRX2 14 GO:2000027 regulation of animal organ morphogenesis 17/1115 125/18722 0.00119149544849373 0.0170754664047277 LGR4/ZNRF3/DAAM1/MAGED1/BMP7/RYK/DVL3/BTBD7/FZD6/AHI1/BMPR1A/FZD3/SMURF2/PTK7/GPC3/CTNNB1/RHOA 17 GO:0072073 kidney epithelium development 18/1115 136/18722 0.00119294792451085 0.0170754664047277 LAMA5/LGR4/IQGAP1/PBX1/MAGED1/BMP7/DLG1/JAG1/MTSS1/GLI3/SMAD2/AHI1/PKD2/FGFR2/CAT/GPC3/CTNNB1/IRX2 18 GO:0060348 bone development 24/1115 205/18722 0.00119873305896644 0.0171123951920369 FBN1/LRP5/GLG1/PLXNB1/BBX/GJA1/SLC38A10/P3H1/TRIP11/AKAP13/LTBP3/ATP6AP1/TRPV4/GLI3/BMPR2/FOXP1/MAPK14/TSKU/ITGB6/FGFR2/DHRS3/ANXA2/RHOA/WASF2 24 GO:0007596 blood coagulation 25/1115 217/18722 0.00120602623325808 0.0171705974916397 F5/IL6ST/ANXA5/LMAN1/FBLN1/ACTG1/PPIA/TFPI/ANO6/GNAQ/MYL12A/GNA12/FN1/JMJD1C/F11R/HSPB1/VAV3/C1QTNF1/AK3/FZD6/MAPK14/HPS5/CAV1/ACTB/ANXA2 25 GO:0140694 non-membrane-bounded organelle assembly 37/1115 367/18722 0.00123839194578097 0.0175845069109697 RPL23A/KRT19/RPL3/ITGB1/KRT8/RPL6/RPLP0/NPM1/RPL5/ACTG1/PRKDC/PRRC2C/PLEC/RPS3/TPR/CDS1/NCOR1/RPL24/AKAP13/DYNC1H1/RPSA/RPL38/CNOT6L/PUM2/C9orf72/KPNB1/SENP6/CEP152/CFLAR/ASAP1/ZNF207/OBSL1/RC3H1/CDC20/HSPA1A/RHOA/LSM3 37 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 8/1115 37/18722 0.00126591672761673 0.0179276642141796 HNRNPA1/TNKS2/PKIB/DHX36/HNRNPA2B1/ATM/CTNNB1/CCT3 8 GO:0019082 viral protein processing 7/1115 29/18722 0.00127839864134596 0.0180565353072648 CANX/FURIN/MOGS/MAN2A1/SPCS3/MGAT1/MAN1B1 7 GO:0045995 regulation of embryonic development 11/1115 64/18722 0.00128651333989786 0.0180857253720184 LAMA5/DAG1/NIPBL/CFL1/B4GALT5/AMOT/TRIP12/DHX36/INSR/TDG/CTNNB1 11 GO:0007163 establishment or maintenance of cell polarity 25/1115 218/18722 0.00128724024000131 0.0180857253720184 ITGB1/KANK1/DST/GJA1/DOCK8/HSP90AB1/DLG5/ARFGEF1/SLC9A1/DLG1/MPP7/ROCK1/RICTOR/FAT1/FERMT1/PRKCI/AMOT/FRMD4A/RHOBTB3/RHOBTB1/ACTB/CYTH3/PTK7/ARF4/RHOA 25 GO:0035637 multicellular organismal signaling 20/1115 160/18722 0.00134606022320688 0.0187020986645463 AKAP9/ATP2B1/DSC2/ATP2B4/GJA1/CALM1/ANK3/PLEC/DSG2/P2RX4/YWHAE/SLC9A1/ATP2A2/GJA5/ATP1A1/DSP/PKP2/CAV1/ISL1/SOD1 20 GO:0048569 post-embryonic animal organ development 5/1115 15/18722 0.00134862483346139 0.0187020986645463 FBN1/EFEMP1/LDHA/FZD5/MYO7A 5 GO:0051127 positive regulation of actin nucleation 5/1115 15/18722 0.00134862483346139 0.0187020986645463 SCIN/NCKAP1/WASL/ABI2/WASF2 5 GO:0086069 bundle of His cell to Purkinje myocyte communication 5/1115 15/18722 0.00134862483346139 0.0187020986645463 DSC2/DSG2/GJA5/DSP/PKP2 5 GO:2001028 positive regulation of endothelial cell chemotaxis 5/1115 15/18722 0.00134862483346139 0.0187020986645463 MET/LGMN/P2RX4/TMSB4X/HSPB1 5 GO:0010828 positive regulation of glucose transmembrane transport 9/1115 46/18722 0.00136224787992133 0.0187449521414948 PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/INSR/OCLN/GPC3 9 GO:0045851 pH reduction 9/1115 46/18722 0.00136224787992133 0.0187449521414948 GRN/ATP6V1B1/ATP6AP1/TMEM106B/CLN5/TTPA/CLCN3/CLN3/ATP6V0A1 9 GO:0072599 establishment of protein localization to endoplasmic reticulum 9/1115 46/18722 0.00136224787992133 0.0187449521414948 SEC62/SEC63/SEC61A1/SPCS3/HSPA5/TRAM1/RAB3GAP1/RAB3GAP2/TRAM2 9 GO:0034764 positive regulation of transmembrane transport 25/1115 219/18722 0.00137312549733408 0.0188460592037704 AKAP9/TCAF1/ITGB1/CALM1/ANO6/ANK3/SLC9A1/ACTN4/KCNN4/KIF5B/PRKCI/DMD/SORBS1/WNK1/TMSB4X/MAPK14/OSBPL8/OPN3/APPL1/ALG10B/INSR/PKD2/OCLN/GPC3/VMP1 25 GO:0032273 positive regulation of protein polymerization 18/1115 138/18722 0.00141240772702196 0.0193354996271032 AKAP9/MET/PFN1/IQGAP2/CLIP1/SCIN/RPS3/MYO1C/DLG1/RICTOR/NCKAP1/WASL/ARPC3/ABI2/OCLN/HSPA1A/RHOA/WASF2 18 GO:0060713 labyrinthine layer morphogenesis 6/1115 22/18722 0.00143805990434693 0.0196363218140876 SPINT1/ZFP36L1/BMP7/ST14/FZD5/FGFR2 6 GO:0006487 protein N-linked glycosylation 11/1115 65/18722 0.00146679670493268 0.0199267878056885 RPN2/STT3B/B4GALT1/MOGS/TUSC3/STT3A/RPN1/MAN1C1/ALG2/ALG10B/MGAT1 11 GO:0071677 positive regulation of mononuclear cell migration 11/1115 65/18722 0.00146679670493268 0.0199267878056885 LGMN/APP/ANO6/DOCK8/ADAM10/CD47/ADAM17/WNK1/HMGB1/PDGFD/RHOA 11 GO:0061008 hepaticobiliary system development 19/1115 150/18722 0.00150015185617141 0.0203281998987288 EGFR/MET/ANXA1/NIPBL/RPS16/NF1/TGFBR3/KRT18/RB1CC1/MAN2A1/SEC63/JARID2/GLI3/COBL/CFLAR/CCND1/ARID5B/PKD2/HNRNPD 19 GO:0033077 T cell differentiation in thymus 12/1115 75/18722 0.00150676774393371 0.0203504087908252 RPS6/ZFP36L1/CD74/PRKDC/FZD5/ADAM17/GLI3/CLPTM1/ERBB2/MR1/CTNNB1/SOD1 12 GO:0002062 chondrocyte differentiation 15/1115 106/18722 0.00151322575200554 0.0203504087908252 EFEMP1/GLG1/SCIN/TRIP11/LTBP3/CREB3L2/TGFBR1/CHST11/NFIB/GLI3/BMPR2/MAPK14/TSKU/BMPR1A/CTNNB1 15 GO:2000278 regulation of DNA biosynthetic process 15/1115 106/18722 0.00151322575200554 0.0203504087908252 HNRNPA1/GJA1/PTGES3/HSP90AB1/TNKS2/PKIB/BMPR2/XRN1/DCP2/HNRNPA2B1/HNRNPC/ATM/CTNNB1/HNRNPD/CCT3 15 GO:0031122 cytoplasmic microtubule organization 10/1115 56/18722 0.0015641298173807 0.0209295466039989 CLIP1/DST/DLG1/PCM1/DYNC1H1/HOOK2/KPNB1/TRPV4/CAMSAP2/RHOA 10 GO:0090175 regulation of establishment of planar polarity 10/1115 56/18722 0.0015641298173807 0.0209295466039989 ZNRF3/DAAM1/RYK/DVL3/FZD6/FZD3/SMURF2/PTK7/GPC3/RHOA 10 GO:1901653 cellular response to peptide 36/1115 359/18722 0.00157060119521161 0.0209635994530869 FBN1/LRP1/ATP2B1/CSH1/KANK1/IGF1R/RPL23/LGMN/APP/ZFP36L1/GJA1/PRKDC/MYO1C/USO1/SLC9A1/GSTP1/PHIP/PTPRA/GAB1/ROCK1/DENND4C/AHCYL1/PRKCI/KLF10/SMARCC1/SORBS1/SOGA1/OSBPL8/CFLAR/CAV1/RAB13/APPL1/RAB31/SLC2A8/INSR/FOXO4 36 GO:0140058 neuron projection arborization 7/1115 30/18722 0.00158283006800534 0.0210741389852381 LRP2/NRP1/MACF1/ROCK1/TPBG/DVL3/MOV10 7 GO:0050885 neuromuscular process controlling balance 9/1115 47/18722 0.00159730716983084 0.0211929837301453 APP/GAA/IGDCC3/HEXB/GM2A/SLC1A3/TPP1/MYO7A/CLN3 9 GO:0044262 cellular carbohydrate metabolic process 30/1115 283/18722 0.00159969515700478 0.0211929837301453 IL6ST/AGL/GAA/SLC5A3/GLB1/PTGES3/PHKB/RANBP2/B4GALT1/RB1CC1/NCOR1/SCARB2/DDB1/B4GALT5/B3GNT2/GNPTAB/TPI1/GUSB/SLC35B4/B3GNT3/EPM2AIP1/SORBS1/GNE/C1QTNF1/HMGB1/SOGA1/NCOA2/INSR/ISYNA1/IDH1 30 GO:0007599 hemostasis 25/1115 222/18722 0.00166101566127142 0.0218708951256412 F5/IL6ST/ANXA5/LMAN1/FBLN1/ACTG1/PPIA/TFPI/ANO6/GNAQ/MYL12A/GNA12/FN1/JMJD1C/F11R/HSPB1/VAV3/C1QTNF1/AK3/FZD6/MAPK14/HPS5/CAV1/ACTB/ANXA2 25 GO:0050817 coagulation 25/1115 222/18722 0.00166101566127142 0.0218708951256412 F5/IL6ST/ANXA5/LMAN1/FBLN1/ACTG1/PPIA/TFPI/ANO6/GNAQ/MYL12A/GNA12/FN1/JMJD1C/F11R/HSPB1/VAV3/C1QTNF1/AK3/FZD6/MAPK14/HPS5/CAV1/ACTB/ANXA2 25 GO:0051893 regulation of focal adhesion assembly 11/1115 66/18722 0.00166725122984379 0.0218708951256412 LRP1/IQGAP1/NRP1/MACF1/ACTG1/SLC9A1/PTPRA/ROCK1/S100A10/EFNA5/RHOA 11 GO:0090109 regulation of cell-substrate junction assembly 11/1115 66/18722 0.00166725122984379 0.0218708951256412 LRP1/IQGAP1/NRP1/MACF1/ACTG1/SLC9A1/PTPRA/ROCK1/S100A10/EFNA5/RHOA 11 GO:0045446 endothelial cell differentiation 16/1115 118/18722 0.00169236584108298 0.0221168812332837 MET/FSTL1/NRP1/JAG1/ROCK1/NR2F2/RBPJ/F11R/BMPR2/S1PR2/S1PR3/ZDHHC21/ACVR2B/RAPGEF2/CTNNB1/FASN 16 GO:0072028 nephron morphogenesis 12/1115 76/18722 0.00169428814841974 0.0221168812332837 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 12 GO:0048771 tissue remodeling 21/1115 175/18722 0.00173564252902141 0.0226014523474276 EGFR/LRP5/LGR4/NF1/GJA1/LIPA/SYT7/LTBP3/ATP6AP1/JAG1/ROCK1/TFRC/SUCO/TPP1/RBPJ/TMEM64/BMPR2/CAV1/PPP3CA/ACVR2B/CTNNB1 21 GO:0021915 neural tube development 19/1115 152/18722 0.00175353538279902 0.0227788939385985 LRP2/SPINT1/PFN1/ZFP36L1/HECTD1/BMP7/PLXNB2/ST14/FOLR1/DVL3/GLI3/MIB1/SETD2/FZD6/COBL/PHACTR4/PKD2/FZD3/PTK7 19 GO:0070252 actin-mediated cell contraction 14/1115 97/18722 0.00177158842303243 0.0229575499771121 AKAP9/DSC2/GJA1/DSG2/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/ATP1A1/DSP/PKP2/CAV1/MYL6 14 GO:0033619 membrane protein proteolysis 10/1115 57/18722 0.00179753791130659 0.0232374210858738 DAG1/SPPL2A/FURIN/ADAM10/ROCK1/NCSTN/ADAM17/SPPL2B/HM13/ERAP1 10 GO:0086091 regulation of heart rate by cardiac conduction 8/1115 39/18722 0.00181514545970786 0.0233417251603341 AKAP9/DSC2/DSG2/YWHAE/DSP/PKP2/CAV1/ISL1 8 GO:0050680 negative regulation of epithelial cell proliferation 20/1115 164/18722 0.00181872217020023 0.0233417251603341 CDK6/FLT1/NF1/GJA1/TGFBR3/SERPINF1/MAGED1/DLG1/TGFBR1/NR2F2/MTSS1/PTPRM/NFIB/PTPRK/CAV1/SUZ12/FGFR2/ISL1/GPC3/CDKN1C 20 GO:2001242 regulation of intrinsic apoptotic signaling pathway 20/1115 164/18722 0.00181872217020023 0.0233417251603341 TPT1/MIF/CD74/PPIA/RPS3/USP47/RPL26/ENO1/GRINA/SERINC3/P4HB/HSPB1/RRM2B/CAV1/DNAJA1/EIF5A/HSPA1A/WFS1/SOD1/YBX3 20 GO:0018279 protein N-linked glycosylation via asparagine 6/1115 23/18722 0.0018486222354964 0.0236119476442949 RPN2/STT3B/TUSC3/STT3A/RPN1/MGAT1 6 GO:1904666 regulation of ubiquitin protein ligase activity 6/1115 23/18722 0.0018486222354964 0.0236119476442949 RPS20/RPL23/RPL5/SKP1/UBE2C/CDC20 6 GO:0048041 focal adhesion assembly 13/1115 87/18722 0.00185485815585935 0.0236350541626088 LRP1/IQGAP1/NRP1/MACF1/ACTG1/SLC9A1/PTPRA/ROCK1/SORBS1/S100A10/PTPRK/EFNA5/RHOA 13 GO:0010649 regulation of cell communication by electrical coupling 5/1115 16/18722 0.00186615704034746 0.0236660627990857 GJA1/CALM1/ANK3/GJA5/CAV1 5 GO:0061548 ganglion development 5/1115 16/18722 0.00186615704034746 0.0236660627990857 NRP2/NRP1/SEMA3F/FZD3/CTNNB1 5 GO:0009880 embryonic pattern specification 11/1115 67/18722 0.00188952071821388 0.0239055713614784 NRP2/NRP1/PGAP1/SEMA3F/BMP7/FZD5/MEIS2/SMAD2/COBL/FGFR2/CTNNB1 11 GO:0021675 nerve development 12/1115 77/18722 0.00190057281631989 0.0239885538211156 DAG1/NRP2/NRP1/DICER1/SEMA3F/ERBB3/RPL24/SLC1A3/GLI3/ISL1/NAV2/CTNNB1 12 GO:0006613 cotranslational protein targeting to membrane 7/1115 31/18722 0.00194081223994912 0.0243811683507961 SEC62/SEC63/SEC61A1/TRAM1/SSR1/SIL1/TRAM2 7 GO:0030201 heparan sulfate proteoglycan metabolic process 7/1115 31/18722 0.00194081223994912 0.0243811683507961 EXTL2/HS6ST2/DSE/GPC1/TCF7L2/B3GAT3/CTNNB1 7 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 4/1115 10/18722 0.001966137219482 0.024641330081724 NCKAP1/WASL/ABI2/WASF2 4 GO:0006612 protein targeting to membrane 17/1115 131/18722 0.00199911523575376 0.024995963099975 TCAF1/NACA/SEC62/ANK3/MYO1C/SEC63/SEC61A1/HSPA5/PRKCI/TRAM1/SSR1/ZDHHC20/SIL1/ZDHHC21/STOM/TRAM2/ERBB2 17 GO:0043583 ear development 24/1115 213/18722 0.00201905951832545 0.0251276428166424 LGR5/NIPBL/ADAM10/ATP6V1B1/LRP10/MCOLN3/TRIP11/JAG1/RPL38/RBPJ/GLI3/MYO7A/NAGLU/DDR1/ESRP1/FZD6/AHI1/TSKU/MYO6/FGFR2/FZD3/FREM2/PTK7/SOD1 24 GO:0051651 maintenance of location in cell 24/1115 213/18722 0.00201905951832545 0.0251276428166424 AKAP9/FTH1/HSP90B1/GAA/SCIN/GJA1/CALM1/ANK3/ARHGAP21/ITPR2/MCOLN3/VPS13C/SLC30A7/GPAA1/VPS13A/HSPA5/DMD/TMSB4X/CAV1/PKD2/SKP1/IBTK/ATP7B/FTL 24 GO:0016052 carbohydrate catabolic process 19/1115 154/18722 0.00204220890214831 0.0253566356478369 GAPDH/LRP5/AGL/LDHA/APP/GAA/ALDOA/GLB1/HEXB/MANBA/RB1CC1/NCOR1/GM2A/ENO1/SCARB2/TPI1/GUSB/HMGB1/INSR 19 GO:0043666 regulation of phosphoprotein phosphatase activity 10/1115 58/18722 0.00205830095864596 0.0254971434297234 HSP90B1/SLC39A10/BOD1L1/CALM1/HSP90AB1/ROCK1/PPP6R2/PPP1R12A/PPP6R3/PPP1R15B 10 GO:0040013 negative regulation of locomotion 38/1115 391/18722 0.002071950266664 0.0256068112817572 LRP1/DAG1/CDH1/ADGRG1/TCAF1/SEMA6D/KANK1/NRP1/SEMA6A/FBLN1/ATP2B4/MIF/DPP4/CD74/NF1/SEMA3F/GJA1/SERPINF1/DLG5/GNA12/GSTP1/JAG1/RYK/SEMA4B/NR2F2/PTPRM/MIA3/WASL/NISCH/HMGB1/SEMA7A/S1PR2/PTPRK/OSBPL8/BMPR1A/CCDC125/SRGAP1/RHOA 38 GO:1902305 regulation of sodium ion transmembrane transport 11/1115 68/18722 0.002135323282745 0.0262662578758809 UTRN/ATP2B4/ANK3/SLC9A1/DLG1/ACTN4/KIF5B/GPD1L/DMD/WNK1/STOM 11 GO:0014037 Schwann cell differentiation 8/1115 40/18722 0.00215240009731321 0.0262662578758809 DAG1/ITGB4/DICER1/NF1/ERBB3/PLEC/GPC1/SOD1 8 GO:0030501 positive regulation of bone mineralization 8/1115 40/18722 0.00215240009731321 0.0262662578758809 FBN2/ATP2B1/ANO6/BMP7/BMPR2/BMPR1A/ACVR2B/ATRAID 8 GO:0060249 anatomical structure homeostasis 32/1115 314/18722 0.00215539158247131 0.0262662578758809 EGFR/LAMC1/ATP2B1/ITGB1/SLC2A1/PRDX1/GAA/ACTG1/ALDOA/NF1/GJA1/GCNT2/P2RX4/LIPA/TAOK1/LTBP3/SLC28A2/ATP6AP1/SLC22A5/TFRC/TPP1/DMD/CLCN3/TMEM64/F11R/HSPB1/AKT3/ACTB/ITGB6/OCLN/CTNNB1/SOD1 32 GO:0018198 peptidyl-cysteine modification 9/1115 49/18722 0.00216466631679857 0.0262662578758809 GAPDH/ATP2B4/RAB6A/DMD/ZDHHC20/ZDHHC17/ZDHHC21/OXR1/PRDX3 9 GO:0045778 positive regulation of ossification 9/1115 49/18722 0.00216466631679857 0.0262662578758809 FBN2/ATP2B1/NIPBL/ANO6/BMP7/BMPR2/BMPR1A/ACVR2B/ATRAID 9 GO:0060964 regulation of gene silencing by miRNA 9/1115 49/18722 0.00216466631679857 0.0262662578758809 EGFR/NEAT1/KCNQ1OT1/TNRC6B/NCOR1/PUM2/PUM1/AGO2/PPP3CA 9 GO:0070169 positive regulation of biomineral tissue development 9/1115 49/18722 0.00216466631679857 0.0262662578758809 FBN2/ATP2B1/ANO6/BMP7/SLC4A2/BMPR2/BMPR1A/ACVR2B/ATRAID 9 GO:0061387 regulation of extent of cell growth 15/1115 110/18722 0.00219977561720018 0.0266317506127704 LRP1/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/SEMA3F/NRCAM/CDKL5/FN1/RYK/SEMA4B/BMPR2/SEMA7A 15 GO:0090257 regulation of muscle system process 27/1115 252/18722 0.00229261925579813 0.0276929733183398 AKAP9/DAG1/ATP2B1/IL6ST/DSC2/ATP2B4/CALM1/DSG2/P2RX4/ENO1/SLC9A1/DLG1/ATP2A2/ROCK1/GJA5/DMD/JARID2/ATP1A1/TRPV4/DSP/PKP2/CAV1/ZDHHC21/PPP3CA/PPP1R12B/RHOA/SOD1 27 GO:0071375 cellular response to peptide hormone stimulus 30/1115 290/18722 0.00232659445124994 0.0280399272578407 FBN1/ATP2B1/CSH1/KANK1/IGF1R/ZFP36L1/PRKDC/MYO1C/USO1/SLC9A1/GSTP1/PHIP/PTPRA/GAB1/ROCK1/DENND4C/AHCYL1/PRKCI/SMARCC1/SORBS1/SOGA1/OSBPL8/CFLAR/CAV1/RAB13/APPL1/RAB31/SLC2A8/INSR/FOXO4 30 GO:0018196 peptidyl-asparagine modification 6/1115 24/18722 0.0023421162497727 0.0281634203998568 RPN2/STT3B/TUSC3/STT3A/RPN1/MGAT1 6 GO:0010644 cell communication by electrical coupling 7/1115 32/18722 0.00235839592494812 0.0282320086172602 GJA1/CALM1/ANK3/GJA5/ATP1A1/PKP2/CAV1 7 GO:0051497 negative regulation of stress fiber assembly 7/1115 32/18722 0.00235839592494812 0.0282320086172602 MET/PFN1/ARHGAP28/PPP1R9A/PPFIA1/F11R/WASF2 7 GO:0045807 positive regulation of endocytosis 14/1115 100/18722 0.00237316896165199 0.0282409185852001 LRP1/ANO6/SMPD1/SCYL2/MIB1/WASL/CLN3/AHI1/APPL1/RAB31/INSR/PPP3CA/ANXA2/GPC3 14 GO:0006023 aminoglycan biosynthetic process 12/1115 79/18722 0.00237500888644968 0.0282409185852001 CHPF/HS6ST2/GCNT2/CLTC/HEXA/DSE/B4GALT5/B3GNT2/CHST11/B3GNT3/CHST14/B3GAT3 12 GO:0006029 proteoglycan metabolic process 12/1115 79/18722 0.00237500888644968 0.0282409185852001 CHPF/EXTL2/HS6ST2/DSE/GPC1/TCF7L2/CHST11/BMPR2/CHST14/CANT1/B3GAT3/CTNNB1 12 GO:0071692 protein localization to extracellular region 36/1115 368/18722 0.00239679643509151 0.028362112777415 FBN1/FBN2/EGFR/LRP1/ANXA1/LRP5/WLS/ABCA1/CANX/DPP4/DYNLL1/PPIA/GJA1/FAM3B/EXPH5/LTBP1/SEL1L/P3H1/SYT7/KCNN4/GNPTAB/CCDC186/SLC16A1/TCF7L2/KIF5B/FRMD4A/MYH10/MIA3/PDIA4/SMAD2/RAB13/EFNA5/PPP3CA/REST/ISL1/RHBDF1 36 GO:0007004 telomere maintenance via telomerase 11/1115 69/18722 0.00240645010079958 0.028362112777415 HNRNPA1/PTGES3/HSP90AB1/TNKS2/PKIB/XRN1/DCP2/HNRNPC/ATM/CTNNB1/CCT3 11 GO:0015807 L-amino acid transport 11/1115 69/18722 0.00240645010079958 0.028362112777415 ITGB1/SLC38A2/SLC43A2/SLC1A5/ARL6IP5/SLC38A9/SLC7A6/SERINC3/SLC38A1/SLC7A2/SLC1A3 11 GO:1904377 positive regulation of protein localization to cell periphery 11/1115 69/18722 0.00240645010079958 0.028362112777415 EGFR/LRP1/ITGB1/ATP2B4/SPTBN1/DLG1/KIF5B/PRKCI/SORBS1/CLN3/ACSL3 11 GO:0097305 response to alcohol 27/1115 253/18722 0.00242510279666606 0.0285189952233482 DAG1/ATP2B1/CDH1/RPL15/ABCA1/CALM1/TGFBR3/GLB1/ITPR2/DNMT3A/GSTP1/TGFBR1/RPL10A/ADCY7/XRN1/SMAD2/CCND1/RPL27/FGFR2/CAT/GGH/CTNNB1/EEF1B2/HNRNPD/RHOA/SOD1/HPGD 27 GO:0110151 positive regulation of biomineralization 9/1115 50/18722 0.00250293285964517 0.0291300165930299 FBN2/ATP2B1/ANO6/BMP7/SLC4A2/BMPR2/BMPR1A/ACVR2B/ATRAID 9 GO:0048532 anatomical structure arrangement 5/1115 17/18722 0.00251525335257292 0.0291300165930299 NRP2/NRP1/SEMA3F/HSPA5/BMPR1A 5 GO:0060977 coronary vasculature morphogenesis 5/1115 17/18722 0.00251525335257292 0.0291300165930299 LRP2/NRP1/TGFBR3/TGFBR1/SETD2 5 GO:0061158 3'-UTR-mediated mRNA destabilization 5/1115 17/18722 0.00251525335257292 0.0291300165930299 ZFP36L1/DHX36/MOV10/RC3H1/HNRNPD 5 GO:0061298 retina vasculature development in camera-type eye 5/1115 17/18722 0.00251525335257292 0.0291300165930299 LRP5/NRP1/COL4A1/BMPR2/ACVR2B 5 GO:1901550 regulation of endothelial cell development 5/1115 17/18722 0.00251525335257292 0.0291300165930299 ROCK1/F11R/S1PR2/S1PR3/ZDHHC21 5 GO:1903140 regulation of establishment of endothelial barrier 5/1115 17/18722 0.00251525335257292 0.0291300165930299 ROCK1/F11R/S1PR2/S1PR3/ZDHHC21 5 GO:0035304 regulation of protein dephosphorylation 13/1115 90/18722 0.00252759395194202 0.0291464883572753 HSP90B1/SLC39A10/BOD1L1/PPIA/CALM1/HSP90AB1/YWHAE/ROCK1/SMPD1/PPP6R2/PPP1R12A/PPP6R3/PPP1R15B 13 GO:0046849 bone remodeling 13/1115 90/18722 0.00252759395194202 0.0291464883572753 EGFR/LRP5/LGR4/NF1/GJA1/SYT7/LTBP3/ATP6AP1/TFRC/SUCO/TPP1/TMEM64/CTNNB1 13 GO:0042307 positive regulation of protein import into nucleus 8/1115 41/18722 0.00253697058038483 0.0291915645014538 CDH1/TPR/HSP90AB1/UBR5/GLI3/MAPK14/RAN/MAVS 8 GO:0002262 myeloid cell homeostasis 19/1115 157/18722 0.00254969652190854 0.0292120809666732 ANXA1/CDK6/RPS6/PRDX1/ZFP36L1/TGFBR3/PRKDC/RPS17/SLC11A2/UFL1/IREB2/NCSTN/ADAM17/PTBP3/HMGB1/MAPK14/P4HTM/HSPA1A/SOD1 19 GO:0051017 actin filament bundle assembly 19/1115 157/18722 0.00254969652190854 0.0292120809666732 MET/PFN1/NRP1/HSP90B1/ITGB5/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/MTSS1/SORBS1/PPFIA1/S100A10/F11R/RHOA/WASF2 19 GO:0007422 peripheral nervous system development 12/1115 80/18722 0.00264608888908119 0.0302515387126434 DAG1/ITGB4/DICER1/SLC5A3/NF1/ERBB3/PLEC/GPC1/EDNRB/ISL1/ERBB2/SOD1 12 GO:0055008 cardiac muscle tissue morphogenesis 10/1115 60/18722 0.00267105071953637 0.0304716662213775 LRP2/TGFBR3/TGFBR1/RBPJ/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1 10 GO:0043488 regulation of mRNA stability 19/1115 158/18722 0.0027407456878805 0.0312000879053176 NPM1/ZFP36L1/YBX1/TNRC6B/ROCK1/CNOT6L/PUM2/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/RC3H1/HNRNPD/FUS/YBX3 19 GO:0001894 tissue homeostasis 28/1115 268/18722 0.00277208352411661 0.0314896892239544 EGFR/LAMC1/ITGB1/SLC2A1/PRDX1/ACTG1/NF1/GJA1/GCNT2/P2RX4/LIPA/LTBP3/SLC28A2/ATP6AP1/SLC22A5/TFRC/TPP1/DMD/CLCN3/TMEM64/F11R/HSPB1/AKT3/ACTB/ITGB6/OCLN/CTNNB1/SOD1 28 GO:0001657 ureteric bud development 13/1115 91/18722 0.00279185605075536 0.03157991409954 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GLI3/SMAD2/PKD2/FGFR2/CAT/GPC3/CTNNB1 13 GO:0072080 nephron tubule development 13/1115 91/18722 0.00279185605075536 0.03157991409954 LAMA5/LGR4/PBX1/MAGED1/DLG1/JAG1/MTSS1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 13 GO:0042326 negative regulation of phosphorylation 37/1115 385/18722 0.00284675761722767 0.0319785615839578 LRP1/LRP5/NPM1/FBLN1/PLPP3/DYNLL1/NF1/PPIA/CALM1/PRKDC/PLEC/BMP7/GNAQ/NCOR1/GSTP1/ROCK1/NR2F2/SMPD1/GPD1L/PARP14/PKIB/DMD/C9orf72/LATS2/WNK1/DNAJC3/HSPB1/IPO7/CAV1/PPP1R15B/SUZ12/PIK3IP1/IBTK/DNAJA1/OCLN/PRDX3/CDKN1C 37 GO:0001889 liver development 18/1115 147/18722 0.00287052275440902 0.0319785615839578 EGFR/MET/ANXA1/RPS16/NF1/TGFBR3/KRT18/RB1CC1/MAN2A1/SEC63/JARID2/GLI3/COBL/CFLAR/CCND1/ARID5B/PKD2/HNRNPD 18 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 32/1115 320/18722 0.00289682286296011 0.0319785615839578 HNRNPA1/SON/NPM1/MBNL3/MBNL2/RBM25/LUC7L3/DDX17/SF1/RBM6/RBM5/SRSF3/MBNL1/HNRNPH1/PNN/SCAF11/SF3B1/CELF1/HNRNPA2B1/TRA2B/HNRNPC/REST/CDK13/NCL/SNRPD2/SNRPF/SAP18/SNRPD1/SRSF9/SNRPB/LSM3/HNRNPA3 32 GO:0000398 mRNA splicing, via spliceosome 32/1115 320/18722 0.00289682286296011 0.0319785615839578 HNRNPA1/SON/NPM1/MBNL3/MBNL2/RBM25/LUC7L3/DDX17/SF1/RBM6/RBM5/SRSF3/MBNL1/HNRNPH1/PNN/SCAF11/SF3B1/CELF1/HNRNPA2B1/TRA2B/HNRNPC/REST/CDK13/NCL/SNRPD2/SNRPF/SAP18/SNRPD1/SRSF9/SNRPB/LSM3/HNRNPA3 32 GO:0015012 heparan sulfate proteoglycan biosynthetic process 6/1115 25/18722 0.00292850485652077 0.0319785615839578 EXTL2/HS6ST2/DSE/TCF7L2/B3GAT3/CTNNB1 6 GO:0031579 membrane raft organization 6/1115 25/18722 0.00292850485652077 0.0319785615839578 DLG1/NPC1/S100A10/CLN3/CAV1/ANXA2 6 GO:0060706 cell differentiation involved in embryonic placenta development 6/1115 25/18722 0.00292850485652077 0.0319785615839578 KRT19/KRT8/HECTD1/ST14/FZD5/NR2F2 6 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 6/1115 25/18722 0.00292850485652077 0.0319785615839578 GJA1/CALM1/GJA5/ATP1A1/PKP2/CAV1 6 GO:1901798 positive regulation of signal transduction by p53 class mediator 6/1115 25/18722 0.00292850485652077 0.0319785615839578 RPS20/RPL23/RPL26/EIF5A/ATM/PLA2R1 6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 12/1115 81/18722 0.00294178846514545 0.0319785615839578 FBN1/FBN2/GLG1/TGFBR3/LTBP1/ZNF451/HSPA5/CHST11/ADAM17/CAV1/SMURF2/HSPA1A 12 GO:0060968 regulation of gene silencing 12/1115 81/18722 0.00294178846514545 0.0319785615839578 EGFR/NEAT1/KCNQ1OT1/TNRC6B/TPR/NCOR1/MPHOSPH8/PUM2/PUM1/AGO2/PPP3CA/ATF7IP 12 GO:0032200 telomere organization 19/1115 159/18722 0.00294362876392989 0.0319785615839578 HNRNPA1/ATRX/PRKDC/PTGES3/HSP90AB1/SMG1/RIF1/TNKS2/PKIB/XRN1/DHX36/DCP2/HNRNPA2B1/YLPM1/HNRNPC/ATM/CTNNB1/HNRNPD/CCT3 19 GO:0051170 import into nucleus 19/1115 159/18722 0.00294362876392989 0.0319785615839578 CDH1/HNRNPA1/RPL23/TPR/HSP90AB1/UBR5/RANBP2/TNPO1/FERMT1/KPNB1/GLI3/IPO7/MAPK14/RAN/APPL1/RANBP17/PPP3CA/MAVS/IPO9 19 GO:0007042 lysosomal lumen acidification 4/1115 11/18722 0.00294477545523548 0.0319785615839578 GRN/TMEM106B/CLN5/CLN3 4 GO:0035581 sequestering of extracellular ligand from receptor 4/1115 11/18722 0.00294477545523548 0.0319785615839578 FBN1/FBN2/CD46/LTBP1 4 GO:0045793 positive regulation of cell size 4/1115 11/18722 0.00294477545523548 0.0319785615839578 HSP90AB1/RB1CC1/AKT3/TMEM123 4 GO:0060742 epithelial cell differentiation involved in prostate gland development 4/1115 11/18722 0.00294477545523548 0.0319785615839578 PSAP/FEM1B/FGFR2/CTNNB1 4 GO:0072497 mesenchymal stem cell differentiation 4/1115 11/18722 0.00294477545523548 0.0319785615839578 KRT18/LTBP3/REST/CTNNB1 4 GO:1902915 negative regulation of protein polyubiquitination 4/1115 11/18722 0.00294477545523548 0.0319785615839578 PPIA/UBR5/TRIM44/TRIP12 4 GO:0006898 receptor-mediated endocytosis 26/1115 244/18722 0.00294689123418379 0.0319785615839578 LRP2/LRP1/ITGB1/ITGAV/CANX/AAK1/CLTC/VLDLR/SCARB2/FOLR1/LMBRD1/TFRC/SCYL2/WASL/CLTA/DNAJC6/CLN3/AHI1/CAV1/AP2A2/RAB31/ITSN2/INSR/MKLN1/ANXA2/PLA2R1 26 GO:0045773 positive regulation of axon extension 8/1115 42/18722 0.00297323660161673 0.0321990065233909 LRP1/GOLGA4/NRP1/MACF1/CDKL5/FN1/BMPR2/SEMA7A 8 GO:0006402 mRNA catabolic process 25/1115 232/18722 0.00302353013177848 0.0323777961435552 NPM1/ZFP36L1/YBX1/TNRC6B/SMG1/ROCK1/TTC37/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/RC3H1/ATM/HSPA1A/HNRNPD/SND1/FUS/YBX3 25 GO:0030865 cortical cytoskeleton organization 10/1115 61/18722 0.00302784822430195 0.0323777961435552 PLEC/DLG1/ROCK1/FMNL2/NCKAP1/RHOBTB3/TRPV4/RHOBTB1/RAB13/RHOA 10 GO:0034113 heterotypic cell-cell adhesion 10/1115 61/18722 0.00302784822430195 0.0323777961435552 ITGB1/ITGAV/DSC2/GCNT2/DSG2/BMP7/CD47/WNK1/DSP/PKP2 10 GO:0042255 ribosome assembly 10/1115 61/18722 0.00302784822430195 0.0323777961435552 RPL23A/RPL3/RPL6/RPLP0/NPM1/RPL5/PRKDC/RPL24/RPSA/RPL38 10 GO:0003208 cardiac ventricle morphogenesis 11/1115 71/18722 0.00303219667948634 0.0323777961435552 LRP2/TGFBR3/JAG1/TGFBR1/RBPJ/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1 11 GO:0072078 nephron tubule morphogenesis 11/1115 71/18722 0.00303219667948634 0.0323777961435552 LAMA5/LGR4/PBX1/MAGED1/DLG1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 11 GO:0150116 regulation of cell-substrate junction organization 11/1115 71/18722 0.00303219667948634 0.0323777961435552 LRP1/IQGAP1/NRP1/MACF1/ACTG1/SLC9A1/PTPRA/ROCK1/S100A10/EFNA5/RHOA 11 GO:0072163 mesonephric epithelium development 13/1115 92/18722 0.00307825416634944 0.0327386434146208 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GLI3/SMAD2/PKD2/FGFR2/CAT/GPC3/CTNNB1 13 GO:0072164 mesonephric tubule development 13/1115 92/18722 0.00307825416634944 0.0327386434146208 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GLI3/SMAD2/PKD2/FGFR2/CAT/GPC3/CTNNB1 13 GO:0050773 regulation of dendrite development 14/1115 103/18722 0.0031339502163876 0.033264732018476 IQGAP1/CUX1/BMP7/CDKL5/VLDLR/TMEM106B/DHX36/COBL/CAMSAP2/OBSL1/PPP3CA/RAPGEF2/CDC20/RHOA 14 GO:0043010 camera-type eye development 32/1115 322/18722 0.00318812434984137 0.0337598446628789 FBN1/FBN2/TENM3/ATP2B1/EFEMP1/LRP5/FLT1/NRP1/ATP2B4/COL4A1/NF1/SERPINF1/BMP7/MAN2A1/RPL24/DLG1/JAG1/TGFBR1/FZD5/FAT1/PTPRM/GLI3/BMPR2/NAGLU/RAB3GAP1/AHI1/TSKU/PHACTR4/OBSL1/ABI2/ACVR2B/CTNNB1 32 GO:0007219 Notch signaling pathway 20/1115 172/18722 0.00319324247139049 0.0337598446628789 KRT19/CD46/IL6ST/GALNT11/APP/AAK1/BMP7/SEL1L/ADAM10/MAML2/JAG1/NOTCH3/PRKCI/NCSTN/RBPJ/ADAM17/MIB1/SPEN/S1PR3/SREBF2 20 GO:0060048 cardiac muscle contraction 17/1115 137/18722 0.00322257112873442 0.0340025835105001 AKAP9/DSC2/GAA/GJA1/CALM1/DSG2/P2RX4/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/DSP/PKP2/CAV1 17 GO:0035196 production of miRNAs involved in gene silencing by miRNA 9/1115 52/18722 0.00330448959815221 0.0346220115652182 EGFR/DICER1/NCOR1/PUM2/SMAD2/PUM1/AGO2/HNRNPA2B1/PPP3CA 9 GO:0060147 regulation of posttranscriptional gene silencing 9/1115 52/18722 0.00330448959815221 0.0346220115652182 EGFR/NEAT1/KCNQ1OT1/TNRC6B/NCOR1/PUM2/PUM1/AGO2/PPP3CA 9 GO:0071786 endoplasmic reticulum tubular network organization 5/1115 18/18722 0.00331370067612409 0.0346220115652182 RTN4/TMEM170A/TMEM33/RAB3GAP1/RAB3GAP2 5 GO:1900006 positive regulation of dendrite development 5/1115 18/18722 0.00331370067612409 0.0346220115652182 IQGAP1/BMP7/VLDLR/TMEM106B/COBL 5 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 5/1115 18/18722 0.00331370067612409 0.0346220115652182 ZFP36L1/TNRC6B/DHX36/AGO2/RC3H1 5 GO:0051592 response to calcium ion 18/1115 149/18722 0.00332527573467022 0.034675092084774 EGFR/IQGAP1/LGMN/CALM1/SYT7/HSPA5/AHCYL1/SEC31A/SMPD1/NCSTN/WNK1/CAV1/CCND1/ALG2/PKD2/PPP3CA/HNRNPD/FUS 18 GO:0061572 actin filament bundle organization 19/1115 161/18722 0.00338714530025028 0.03525140108779 MET/PFN1/NRP1/HSP90B1/ITGB5/ACTG1/SLC9A1/ARHGAP28/ROCK1/CD47/TGFBR1/PPP1R9A/MTSS1/SORBS1/PPFIA1/S100A10/F11R/RHOA/WASF2 19 GO:0000038 very long-chain fatty acid metabolic process 7/1115 34/18722 0.00339776398575448 0.0352800541286624 HACD3/SLC27A2/TECR/SLC27A6/ABCD3/ACOX1/ELOVL1 7 GO:0030278 regulation of ossification 15/1115 115/18722 0.00340311441773013 0.0352800541286624 FBN2/ATP2B1/PBX1/NIPBL/ANO6/BMP7/ANKH/LTBP3/RBPJ/BMPR2/MAPK14/BMPR1A/DHRS3/ACVR2B/ATRAID 15 GO:0046824 positive regulation of nucleocytoplasmic transport 10/1115 62/18722 0.00342161489998256 0.0353346265976923 CDH1/TPR/HSP90AB1/UBR5/YWHAE/TCF7L2/GLI3/MAPK14/RAN/MAVS 10 GO:0060113 inner ear receptor cell differentiation 10/1115 62/18722 0.00342161489998256 0.0353346265976923 MCOLN3/TRIP11/JAG1/RBPJ/MYO7A/NAGLU/ESRP1/TSKU/MYO6/SOD1 10 GO:0016266 O-glycan processing 8/1115 43/18722 0.00346573142759799 0.0354935454836766 GALNT11/GXYLT1/C1GALT1/B4GALT5/B3GNT2/B3GNT5/GCNT4/B3GNT3 8 GO:0030517 negative regulation of axon extension 8/1115 43/18722 0.00346573142759799 0.0354935454836766 SEMA6D/NRP1/SEMA6A/RTN4/SEMA3F/RYK/SEMA4B/SEMA7A 8 GO:0032365 intracellular lipid transport 8/1115 43/18722 0.00346573142759799 0.0354935454836766 ABCA1/SGPP1/SYT7/NPC1/PLEKHA8/CPT2/ABCD3/ANXA2 8 GO:1904591 positive regulation of protein import 8/1115 43/18722 0.00346573142759799 0.0354935454836766 CDH1/TPR/HSP90AB1/UBR5/GLI3/MAPK14/RAN/MAVS 8 GO:0035107 appendage morphogenesis 17/1115 138/18722 0.00347689160666096 0.0354935454836766 FBN2/LRP5/PBX1/NIPBL/ATRX/BMP7/MBNL1/CHST11/GLI3/FZD6/FRAS1/BMPR1A/FGFR2/FREM2/CREBBP/GPC3/CTNNB1 17 GO:0035108 limb morphogenesis 17/1115 138/18722 0.00347689160666096 0.0354935454836766 FBN2/LRP5/PBX1/NIPBL/ATRX/BMP7/MBNL1/CHST11/GLI3/FZD6/FRAS1/BMPR1A/FGFR2/FREM2/CREBBP/GPC3/CTNNB1 17 GO:0007265 Ras protein signal transduction 33/1115 337/18722 0.0034962073117075 0.0356226161015388 ADGRG1/MET/ITGB1/KANK1/NRP1/HACD3/ABCA1/ARHGAP5/CFL1/NF1/RASA1/GNA12/ARFGEF1/NET1/AKAP13/RHOV/ROCK1/DENND4C/NCKAP1/ARHGAP29/ARFGEF3/KPNB1/F11R/NISCH/DHCR24/PHACTR4/ABI2/CYTH3/CCDC125/RAPGEF2/RHOA/WASF2/CDC42SE1 33 GO:0000375 RNA splicing, via transesterification reactions 32/1115 324/18722 0.00350404328773739 0.0356344516442475 HNRNPA1/SON/NPM1/MBNL3/MBNL2/RBM25/LUC7L3/DDX17/SF1/RBM6/RBM5/SRSF3/MBNL1/HNRNPH1/PNN/SCAF11/SF3B1/CELF1/HNRNPA2B1/TRA2B/HNRNPC/REST/CDK13/NCL/SNRPD2/SNRPF/SAP18/SNRPD1/SRSF9/SNRPB/LSM3/HNRNPA3 32 GO:0031397 negative regulation of protein ubiquitination 12/1115 83/18722 0.00361350376720636 0.0366538463942142 RPS20/RPL23/RPL5/PPIA/RPS3/UBR5/UFL1/TRIM44/TRIP12/CAV1/DNAJA1/HSPA1A 12 GO:0060037 pharyngeal system development 6/1115 26/18722 0.00361801405689284 0.0366538463942142 BMP7/FOLR1/TGFBR1/BMPR2/BMPR1A/ISL1 6 GO:0030326 embryonic limb morphogenesis 15/1115 116/18722 0.00369895470713021 0.0373321723655353 FBN2/LRP5/PBX1/NIPBL/BMP7/MBNL1/CHST11/GLI3/FZD6/FRAS1/BMPR1A/FREM2/CREBBP/GPC3/CTNNB1 15 GO:0035113 embryonic appendage morphogenesis 15/1115 116/18722 0.00369895470713021 0.0373321723655353 FBN2/LRP5/PBX1/NIPBL/BMP7/MBNL1/CHST11/GLI3/FZD6/FRAS1/BMPR1A/FREM2/CREBBP/GPC3/CTNNB1 15 GO:0030316 osteoclast differentiation 13/1115 94/18722 0.00372286667105174 0.0375026135032929 FBN1/ATP6AP1/TFRC/IREB2/KLF10/TMEM64/FOXP1/MAPK14/SH3PXD2A/TLR3/ANXA2/GPC3/CTNNB1 13 GO:0007566 embryo implantation 9/1115 53/18722 0.00377446364075959 0.0377375681236244 ITGB4/PRLR/FBLN1/GJA1/DDR1/AGO2/SMURF2/VMP1/SOD1 9 GO:0032210 regulation of telomere maintenance via telomerase 9/1115 53/18722 0.00377446364075959 0.0377375681236244 HNRNPA1/TNKS2/PKIB/XRN1/DCP2/HNRNPC/ATM/CTNNB1/CCT3 9 GO:0051438 regulation of ubiquitin-protein transferase activity 9/1115 53/18722 0.00377446364075959 0.0377375681236244 RPS20/RPL23/RPL5/RPS2/UBE2L3/FEM1B/SKP1/UBE2C/CDC20 9 GO:0060966 regulation of gene silencing by RNA 9/1115 53/18722 0.00377446364075959 0.0377375681236244 EGFR/NEAT1/KCNQ1OT1/TNRC6B/NCOR1/PUM2/PUM1/AGO2/PPP3CA 9 GO:0072088 nephron epithelium morphogenesis 11/1115 73/18722 0.0037824824680677 0.0377470540131093 LAMA5/LGR4/PBX1/MAGED1/DLG1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 11 GO:0048754 branching morphogenesis of an epithelial tube 18/1115 151/18722 0.00383826881974617 0.0382323082623597 LAMA5/DAG1/MET/LRP5/LGR4/NRP1/PBX1/COL4A1/MAGED1/BMP7/DLG5/DLG1/GLI3/DDR1/PKD2/FGFR2/GPC3/CTNNB1 18 GO:0033044 regulation of chromosome organization 21/1115 187/18722 0.0038734211191897 0.0385106058758916 HNRNPA1/ATRX/TPR/SMG1/MPHOSPH8/TNKS2/PKIB/SENP6/XRN1/DHX36/DCP2/HNRNPA2B1/ZNF207/YLPM1/HNRNPC/ATF7IP/ATM/UBE2C/CTNNB1/HNRNPD/CCT3 21 GO:0043270 positive regulation of ion transport 28/1115 275/18722 0.00398813523835625 0.0394566042373713 AKAP9/ATP2B1/TCAF1/ITGB1/SLC6A4/PRSS8/CALM1/ANO6/ANK3/P2RX4/SLC9A1/DLG1/ACTN4/KCNN4/KIF5B/AHCYL1/GPD1L/DMD/WNK1/TMSB4X/RAB3GAP1/PKP2/CAV1/ALG10B/PKD2/VMP1/WFS1/PLA2R1 28 GO:0061157 mRNA destabilization 12/1115 84/18722 0.00399287724171128 0.0394566042373713 ZFP36L1/TNRC6B/ROCK1/CNOT6L/CELF1/DHX36/DCP2/PUM1/AGO2/MOV10/RC3H1/HNRNPD 12 GO:0060711 labyrinthine layer development 8/1115 44/18722 0.00401912638767219 0.0394566042373713 SPINT1/ZFP36L1/BMP7/BIRC6/ST14/FZD5/RBPJ/FGFR2 8 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 8/1115 44/18722 0.00401912638767219 0.0394566042373713 RTN4/PUM2/PUM1/HMGB1/CAV1/TLR3/ANKRD17/HSPA1A 8 GO:1903573 negative regulation of response to endoplasmic reticulum stress 8/1115 44/18722 0.00401912638767219 0.0394566042373713 USP25/GRINA/UFL1/HSPA5/PPP1R15B/LPCAT3/HSPA1A/WFS1 8 GO:0032232 negative regulation of actin filament bundle assembly 7/1115 35/18722 0.00403274939149504 0.0394566042373713 MET/PFN1/ARHGAP28/PPP1R9A/PPFIA1/F11R/WASF2 7 GO:0034405 response to fluid shear stress 7/1115 35/18722 0.00403274939149504 0.0394566042373713 ABCA1/GJA1/PLEC/P2RX4/MTSS1/SREBF2/PKD2 7 GO:0086005 ventricular cardiac muscle cell action potential 7/1115 35/18722 0.00403274939149504 0.0394566042373713 DSC2/DSG2/DLG1/GPD1L/DSP/PKP2/CAV1 7 GO:0042886 amide transport 30/1115 301/18722 0.00403508258355585 0.0394566042373713 EGFR/LRP2/LRP1/ANXA1/LRP5/PSAP/ABCA1/SLC19A1/DPP4/CD74/DYNLL1/GJA1/FAM3B/SGPP1/SLC5A6/FOLR1/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/SLC13A3/PLEKHA8/TRPV4/SMAD2/EFNA5/PPP3CA/REST/ISL1/TAPBP 30 GO:0046822 regulation of nucleocytoplasmic transport 14/1115 106/18722 0.00408360017239673 0.0397881083054039 CDH1/TPR/HSP90AB1/UBR5/YWHAE/PTPN14/TCF7L2/FERMT1/PPP1R12A/GLI3/SETD2/MAPK14/RAN/MAVS 14 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 13/1115 95/18722 0.00408388899632166 0.0397881083054039 RPS20/RPL23/RPL5/PPIA/RPS3/UBR5/UFL1/TRIM44/TRIP12/CAV1/DNAJA1/CTNNB1/HSPA1A 13 GO:0052547 regulation of peptidase activity 42/1115 461/18722 0.00410069696008298 0.0398790912019727 GAPDH/SPINT1/CRIM1/LRP1/ITIH5/GRN/APLP2/FBLN1/LGMN/APP/ASPH/TFPI/SERPINF1/CTSD/RPS3/ARL6IP5/FURIN/USP47/BIRC6/FN1/ROCK1/IFI6/NCSTN/SIAH2/CLDN4/DHCR24/HMGB1/CFLAR/CAV1/CAST/XIAP/REST/ANXA2/CYFIP2/SERPINB9/GPC3/CYCS/BIRC5/HSPE1/PRDX3/RHOA/SERPINB1 42 GO:0048839 inner ear development 21/1115 188/18722 0.00412294209337378 0.040022523339132 LGR5/ADAM10/ATP6V1B1/LRP10/MCOLN3/TRIP11/JAG1/RBPJ/GLI3/MYO7A/NAGLU/ESRP1/FZD6/AHI1/TSKU/MYO6/FGFR2/FZD3/FREM2/PTK7/SOD1 21 GO:0120192 tight junction assembly 11/1115 74/18722 0.00420952560476546 0.0404314396208139 ACTG1/GJA1/MYO1C/DLG1/MPP7/ROCK1/FZD5/F11R/CLDN4/RAB13/OCLN 11 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 4/1115 12/18722 0.0042105039200548 0.0404314396208139 SEC62/SEC63/SEC61A1/HSPA5 4 GO:0009886 post-embryonic animal morphogenesis 4/1115 12/18722 0.0042105039200548 0.0404314396208139 FBN1/EFEMP1/ATRX/MYO7A 4 GO:0042118 endothelial cell activation 4/1115 12/18722 0.0042105039200548 0.0404314396208139 PPIA/P2RX4/TGFBR1/FOXP1 4 GO:0071635 negative regulation of transforming growth factor beta production 4/1115 12/18722 0.0042105039200548 0.0404314396208139 FURIN/HSP90AB1/FN1/TSKU 4 GO:0098974 postsynaptic actin cytoskeleton organization 4/1115 12/18722 0.0042105039200548 0.0404314396208139 ACTG1/PPP1R9A/ACTB/WASF2 4 GO:0030050 vesicle transport along actin filament 5/1115 19/18722 0.00427935309497287 0.0408720325117355 MYO1C/ACTN4/WASL/MYO7A/MYO6 5 GO:0035461 vitamin transmembrane transport 5/1115 19/18722 0.00427935309497287 0.0408720325117355 LRP2/SLC19A1/SLC19A3/SLC5A6/FOLR1 5 GO:0045780 positive regulation of bone resorption 5/1115 19/18722 0.00427935309497287 0.0408720325117355 EGFR/LTBP3/ATP6AP1/TFRC/TMEM64 5 GO:0031050 dsRNA processing 9/1115 54/18722 0.00429519636803371 0.0408771005506809 EGFR/DICER1/NCOR1/PUM2/SMAD2/PUM1/AGO2/HNRNPA2B1/PPP3CA 9 GO:0070918 production of small RNA involved in gene silencing by RNA 9/1115 54/18722 0.00429519636803371 0.0408771005506809 EGFR/DICER1/NCOR1/PUM2/SMAD2/PUM1/AGO2/HNRNPA2B1/PPP3CA 9 GO:0032507 maintenance of protein location in cell 10/1115 64/18722 0.00433061019493831 0.0411407968519139 SCIN/GJA1/ANK3/VPS13C/GPAA1/VPS13A/HSPA5/TMSB4X/CAV1/SKP1 10 GO:0032355 response to estradiol 17/1115 141/18722 0.00434113226899403 0.041141781366159 EGFR/ANXA1/SLC6A4/GJA1/TFPI/NCOA3/BMP7/DNMT3A/GSTP1/NR2F2/MMP15/CFLAR/CCND1/CAT/CTNNB1/HNRNPD/HPGD 17 GO:0006413 translational initiation 15/1115 118/18722 0.00435383151749014 0.041141781366159 RPL13A/RPS3A/NPM1/EIF1/RPS3/RPS17/TPR/EIF3A/DNAJC3/HSPB1/AGO2/PPP1R15B/EIF2S2/PAIP2/EIF3H 15 GO:0022612 gland morphogenesis 15/1115 118/18722 0.00435383151749014 0.041141781366159 LAMA5/DAG1/LRP5/NRP1/BMP7/PLXNA1/NFIB/GLI3/BTBD7/DDR1/CFLAR/CAV1/FEM1B/FGFR2/PLAG1 15 GO:0001656 metanephros development 12/1115 85/18722 0.0044035821100516 0.0414833174959177 FBN1/LGR4/NIPBL/NF1/BMP7/DLG5/GLI3/FRAS1/PKD2/GPC3/CTNNB1/IRX2 12 GO:0010586 miRNA metabolic process 6/1115 27/18722 0.00442105406540123 0.0414833174959177 DICER1/KCNQ1OT1/DDX17/AGO2/RC3H1/SND1 6 GO:0033688 regulation of osteoblast proliferation 6/1115 27/18722 0.00442105406540123 0.0414833174959177 ITGAV/LRP5/PLXNB1/FGFR2/ATRAID/RHOA 6 GO:1902914 regulation of protein polyubiquitination 6/1115 27/18722 0.00442105406540123 0.0414833174959177 PPIA/UBR5/TRIM44/TRIP12/SKP2/XIAP 6 GO:0098739 import across plasma membrane 20/1115 177/18722 0.00442966957251162 0.0414912383291922 LRP2/ITGB1/SLC2A1/SLC39A10/ATP2B4/SLC19A1/SLC5A3/SLC43A2/SLC1A5/ARL6IP5/SLC5A6/SLC9A1/DLG1/FOLR1/SLC7A2/SLC1A3/ATP1A1/WNK1/TRPV4/SLC16A2 20 GO:0005976 polysaccharide metabolic process 14/1115 107/18722 0.00444765370457864 0.0415140264488555 IL6ST/AGL/GAA/PTGES3/CLTC/PHKB/RB1CC1/B4GALT5/B3GNT2/B3GNT3/EPM2AIP1/SORBS1/HMGB1/INSR 14 GO:0031532 actin cytoskeleton reorganization 14/1115 107/18722 0.00444765370457864 0.0415140264488555 ANXA1/THSD7A/IQGAP2/NRP1/PLEC/GAB1/RICTOR/TRPV4/F11R/S1PR2/MKLN1/PTK7/NRK/RHOA 14 GO:0001823 mesonephros development 13/1115 96/18722 0.004472660732507 0.0415595307206819 LAMA5/LGR4/PBX1/MAGED1/BMP7/DLG1/GLI3/SMAD2/PKD2/FGFR2/CAT/GPC3/CTNNB1 13 GO:0044264 cellular polysaccharide metabolic process 13/1115 96/18722 0.004472660732507 0.0415595307206819 IL6ST/AGL/GAA/PTGES3/PHKB/RB1CC1/B4GALT5/B3GNT2/B3GNT3/EPM2AIP1/SORBS1/HMGB1/INSR 13 GO:0000082 G1/S transition of mitotic cell cycle 23/1115 214/18722 0.00447588128196144 0.0415595307206819 EGFR/ITGB1/ANXA1/CDK6/RPS6/BRD4/PRKDC/BCAT1/RPL26/DLG1/ADAMTS1/SKP2/LATS2/ADAM17/PIAS1/JADE1/CCND1/APPL1/PKD2/PPP3CA/ANKRD17/ATM/CDKN3 23 GO:0006401 RNA catabolic process 28/1115 278/18722 0.00463267580761583 0.0429175487942762 NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/RC3H1/ATM/HSPA1A/HNRNPD/SND1/FUS/YBX3 28 GO:0003197 endocardial cushion development 8/1115 45/18722 0.0046382142075852 0.0429175487942762 BMP7/MDM4/JAG1/TGFBR1/RBPJ/BMPR2/BMPR1A/ISL1 8 GO:0006024 glycosaminoglycan biosynthetic process 11/1115 75/18722 0.00467406211209592 0.043099857714128 CHPF/HS6ST2/GCNT2/CLTC/HEXA/DSE/B3GNT2/CHST11/B3GNT3/CHST14/B3GAT3 11 GO:0006278 RNA-dependent DNA biosynthetic process 11/1115 75/18722 0.00467406211209592 0.043099857714128 HNRNPA1/PTGES3/HSP90AB1/TNKS2/PKIB/XRN1/DCP2/HNRNPC/ATM/CTNNB1/CCT3 11 GO:0050770 regulation of axonogenesis 18/1115 154/18722 0.00472902829592554 0.0435315208137008 LRP1/SEMA6D/GOLGA4/NRP1/SEMA6A/MACF1/RTN4/PLXNB1/SEMA3F/CDKL5/PLXNB2/PLXNA1/FN1/RYK/SEMA4B/BMPR2/SEMA7A/TRAK2 18 GO:0061013 regulation of mRNA catabolic process 19/1115 166/18722 0.00474402916217796 0.0435944435402205 NPM1/ZFP36L1/YBX1/TNRC6B/ROCK1/CNOT6L/PUM2/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/RC3H1/HNRNPD/FUS/YBX3 19 GO:0048524 positive regulation of viral process 10/1115 65/18722 0.00485130355675751 0.0444674235391735 HACD3/CD74/PPIA/PKN2/DDB1/P4HB/RSF1/TOP2B/STOM/TRIM38 10 GO:0060541 respiratory system development 22/1115 203/18722 0.0048556860691774 0.0444674235391735 EGFR/LAMA5/DAG1/MME/PTGES3/LIPA/DLG5/MAN2A1/MAN1A2/LTBP3/RBPJ/NFIB/GLI3/BMPR2/SMAD2/HMGB1/BMPR1A/ITGB6/FGFR2/PTK7/GPC3/CTNNB1 22 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 13/1115 97/18722 0.00489068382802092 0.0447035734906996 ITGA6/ITGAV/NRP1/BIRC6/RB1CC1/GSTP1/PHIP/TGFBR1/TCF7L2/IFI6/SIAH2/CFLAR/HSPA1A 13 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 16/1115 131/18722 0.00489821885972266 0.0447035734906996 FBN1/FBN2/LRP2/CRIM1/LRP1/GLG1/TGFBR3/LTBP1/ZNF451/HSPA5/CHST11/TRIM33/ADAM17/CAV1/SMURF2/HSPA1A 16 GO:0006865 amino acid transport 17/1115 143/18722 0.0050097381896555 0.0455655744370881 ITGB1/SLC38A2/SLC43A2/GJA1/SLC1A5/SLC17A5/SLC38A10/ARL6IP5/SLC38A9/SLC7A6/SERINC3/SLC38A1/SLC7A2/SLC1A3/RAB3GAP1/CLN3/SLC16A2 17 GO:0030010 establishment of cell polarity 17/1115 143/18722 0.0050097381896555 0.0455655744370881 ITGB1/KANK1/GJA1/DOCK8/HSP90AB1/ARFGEF1/MPP7/ROCK1/RICTOR/FAT1/FERMT1/PRKCI/AMOT/FRMD4A/CYTH3/PTK7/RHOA 17 GO:0006606 protein import into nucleus 18/1115 155/18722 0.00506118502004246 0.045893582303279 CDH1/RPL23/TPR/HSP90AB1/UBR5/RANBP2/TNPO1/FERMT1/KPNB1/GLI3/IPO7/MAPK14/RAN/APPL1/RANBP17/PPP3CA/MAVS/IPO9 18 GO:1903034 regulation of response to wounding 19/1115 167/18722 0.0050629930654863 0.045893582303279 LRP1/ITGB1/GRN/ANXA1/PTPRF/KANK1/ACTG1/PLPP3/GJA1/TFPI/ANO6/ARFGEF1/FERMT1/CLDN4/C1QTNF1/HMGB1/CAV1/ANXA2/OCLN 19 GO:1901888 regulation of cell junction assembly 22/1115 204/18722 0.00514583714446745 0.0465654652784945 LRP1/IQGAP1/NRP1/MACF1/APP/ACTG1/GJA1/MYO1C/DLG5/SLC9A1/PTPRA/ROCK1/FZD5/CLSTN1/PPP1R9A/TPBG/S100A10/F11R/CAV1/EFNA5/RAPGEF2/RHOA 22 GO:0051052 regulation of DNA metabolic process 34/1115 359/18722 0.00515620235417237 0.0465803119609582 EGFR/HNRNPA1/NPM1/ATRX/GJA1/PRKDC/RPS3/PTGES3/HSP90AB1/UBR5/SMG1/RIF1/USP9X/TFRC/MPHOSPH8/TNKS2/TRIP12/PKIB/BMPR2/XRN1/DHX36/SETD2/DCP2/HNRNPA2B1/HMGB1/KMT2A/YLPM1/HNRNPC/ATM/SUB1/CTNNB1/HNRNPD/CCT3/FUS 34 GO:0072009 nephron epithelium development 14/1115 109/18722 0.00525457222569976 0.0473887856638699 LAMA5/LGR4/IQGAP1/PBX1/MAGED1/DLG1/JAG1/MTSS1/GLI3/AHI1/PKD2/GPC3/CTNNB1/IRX2 14 GO:0061014 positive regulation of mRNA catabolic process 12/1115 87/18722 0.00532622714368835 0.0478077509354481 ZFP36L1/TNRC6B/ROCK1/CNOT6L/CELF1/DHX36/DCP2/PUM1/AGO2/MOV10/RC3H1/HNRNPD 12 GO:0060976 coronary vasculature development 8/1115 46/18722 0.00532789132919865 0.0478077509354481 LRP2/ADAMTS6/NRP1/TGFBR3/TGFBR1/SETD2/PTK7/GPC3 8 GO:0061462 protein localization to lysosome 8/1115 46/18722 0.00532789132919865 0.0478077509354481 RTN4/RNF128/SCARB2/GLMP/GCC2/LMBRD1/GNPTAB/LAMP2 8 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 13/1115 98/18722 0.00533949665970569 0.047831497762028 TPT1/MIF/CD74/PPIA/USP47/ENO1/GRINA/HSPB1/RRM2B/DNAJA1/HSPA1A/WFS1/YBX3 13 GO:0001666 response to hypoxia 30/1115 307/18722 0.00534904201219612 0.0478367425512815 MALAT1/SLC2A1/LDHA/HSP90B1/SLC6A4/ZFP36L1/DPP4/NF1/TGFBR3/BMP7/ITPR2/DNMT3A/SLC11A2/MDM4/ENO1/SLC9A1/P4HB/NPEPPS/CHCHD2/RBPJ/ADAM17/SLC29A1/PLOD1/CFLAR/CAV1/SLC2A8/REST/CAT/CREBBP/RHOA 30 GO:0050922 negative regulation of chemotaxis 10/1115 66/18722 0.00541988432942068 0.0483892348407642 SEMA6D/NRP1/SEMA6A/MIF/DPP4/SEMA3F/GSTP1/RYK/SEMA4B/SEMA7A 10 GO:0046931 pore complex assembly 5/1115 20/18722 0.00542991980295671 0.0483978995458863 RTN4/ANO6/ADAM10/TMEM170A/CCT3 5 GO:0001658 branching involved in ureteric bud morphogenesis 9/1115 56/18722 0.00550336623801407 0.0489707872412619 LAMA5/LGR4/PBX1/MAGED1/DLG1/GLI3/PKD2/GPC3/CTNNB1 9 GO:0031112 positive regulation of microtubule polymerization or depolymerization 7/1115 37/18722 0.00556748100118116 0.049435133893734 AKAP9/MET/CLIP1/RPS3/TRPV4/OCLN/HSPA1A 7 GO:1903522 regulation of blood circulation 26/1115 256/18722 0.00557406829069636 0.049435133893734 EGFR/AKAP9/ATP2B1/DSC2/ADRB1/ATP2B4/GAA/GJA1/CALM1/DSG2/P2RX4/YWHAE/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/BMPR2/DSP/PKP2/CAV1/ZDHHC21/ISL1/RHOA 26 GO:0010595 positive regulation of endothelial cell migration 16/1115 133/18722 0.00567383618086595 0.0502365031005693 MET/NRP2/GRN/ANXA1/NRP1/LGMN/PLPP3/P2RX4/ADAM17/BMPR2/TMSB4X/HSPB1/FOXP1/EMC10/AKT3/HMGB1 16 GO:0045732 positive regulation of protein catabolic process 24/1115 231/18722 0.00571977284535906 0.0504155501757713 LRP2/LRP1/CTSC/OAZ1/GJA1/RNF128/HECTD1/FURIN/DDB1/RNF217/WWP1/ZYG11B/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/SMURF2/GPC3/CDC20/HSPA1A 24 GO:0048644 muscle organ morphogenesis 11/1115 77/18722 0.00572462467473312 0.0504155501757713 LRP2/TGFBR3/TGFBR1/RBPJ/DSP/LY6E/PKP2/ARID5B/BMPR1A/FGFR2/ISL1 11 GO:0008016 regulation of heart contraction 22/1115 206/18722 0.00576927002657071 0.0504155501757713 AKAP9/ATP2B1/DSC2/ADRB1/ATP2B4/GAA/GJA1/CALM1/DSG2/P2RX4/YWHAE/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/DSP/PKP2/CAV1/ISL1 22 GO:0007034 vacuolar transport 18/1115 157/18722 0.00578290323683049 0.0504155501757713 LRP1/GRN/PSAP/VPS13C/SCARB2/GCC2/GNPTAB/TMEM106B/LAMP2/VPS13A/NPC1/HGSNAT/HOOK2/C9orf72/SCYL2/CLN3/TRAK2/HSPA1A 18 GO:0006983 ER overload response 4/1115 13/18722 0.00579792991345263 0.0504155501757713 HSPA5/CCDC47/PPP1R15B/WFS1 4 GO:0010960 magnesium ion homeostasis 4/1115 13/18722 0.00579792991345263 0.0504155501757713 EGFR/ANK3/TRPM7/CNNM2 4 GO:0032429 regulation of phospholipase A2 activity 4/1115 13/18722 0.00579792991345263 0.0504155501757713 EGFR/LRP1/ANXA1/PLA2R1 4 GO:0044090 positive regulation of vacuole organization 4/1115 13/18722 0.00579792991345263 0.0504155501757713 GRN/RAB3GAP1/RAB3GAP2/ANXA2 4 GO:0060670 branching involved in labyrinthine layer morphogenesis 4/1115 13/18722 0.00579792991345263 0.0504155501757713 SPINT1/ST14/FZD5/FGFR2 4 GO:1900115 extracellular regulation of signal transduction 4/1115 13/18722 0.00579792991345263 0.0504155501757713 FBN1/FBN2/CD46/LTBP1 4 GO:1900116 extracellular negative regulation of signal transduction 4/1115 13/18722 0.00579792991345263 0.0504155501757713 FBN1/FBN2/CD46/LTBP1 4 GO:0036293 response to decreased oxygen levels 31/1115 322/18722 0.00581542530115424 0.0504854563948984 MALAT1/SLC2A1/LDHA/HSP90B1/SLC6A4/ZFP36L1/DPP4/NF1/TGFBR3/BMP7/ITPR2/DNMT3A/SLC11A2/MDM4/ENO1/SLC9A1/P4HB/NPEPPS/CHCHD2/CPEB4/RBPJ/ADAM17/SLC29A1/PLOD1/CFLAR/CAV1/SLC2A8/REST/CAT/CREBBP/RHOA 31 GO:0050779 RNA destabilization 12/1115 88/18722 0.00584189551894108 0.0506329223630299 ZFP36L1/TNRC6B/ROCK1/CNOT6L/CELF1/DHX36/DCP2/PUM1/AGO2/MOV10/RC3H1/HNRNPD 12 GO:0007346 regulation of mitotic cell cycle 41/1115 457/18722 0.00588413484848545 0.0509163629757922 EGFR/ANXA1/LRP5/IQGAP1/PBX1/LGMN/APP/ZFP36L1/BRD4/PRKDC/BMP7/TPR/USP47/PKN2/YWHAE/RPL26/TAOK1/DLG1/DDB1/PHIP/ADAMTS1/MEIS2/ADAM17/TAOK3/JADE1/CCND1/ZNF207/APPL1/OBSL1/INSR/PKD2/CDK13/ANKRD17/FZD3/FOXO4/CKS1B/ATM/UBE2C/NUSAP1/CTNNB1/CDKN1C 41 GO:0042490 mechanoreceptor differentiation 10/1115 67/18722 0.0060392463664745 0.0520057037913022 MCOLN3/TRIP11/JAG1/RBPJ/MYO7A/NAGLU/ESRP1/TSKU/MYO6/SOD1 10 GO:0061077 chaperone-mediated protein folding 10/1115 67/18722 0.0060392463664745 0.0520057037913022 CD74/PTGES3/DNAJB14/P3H1/HSPA5/CRTAP/HSPB1/PDIA4/HSPA1A/HSPE1 10 GO:0072665 protein localization to vacuole 10/1115 67/18722 0.0060392463664745 0.0520057037913022 RTN4/RNF128/VPS13C/SCARB2/GLMP/GCC2/LMBRD1/GNPTAB/LAMP2/VPS13A 10 GO:0014911 positive regulation of smooth muscle cell migration 8/1115 47/18722 0.00609313936188948 0.0521393346761837 LRP1/SEMA6D/IQGAP1/NRP1/S100A11/ADAMTS1/PDGFD/FOXO4 8 GO:0035315 hair cell differentiation 8/1115 47/18722 0.00609313936188948 0.0521393346761837 MCOLN3/JAG1/RBPJ/MYO7A/ESRP1/MYO6/CTNNB1/SOD1 8 GO:0042552 myelination 16/1115 134/18722 0.0060973710637942 0.0521393346761837 DAG1/ITGB4/DICER1/CTSC/NF1/HEXB/PLEC/DLG1/GPC1/B4GALT5/NCSTN/DEGS1/CMTM8/ERBB2/CTNNB1/SOD1 16 GO:0061041 regulation of wound healing 16/1115 134/18722 0.0060973710637942 0.0521393346761837 ITGB1/ANXA1/KANK1/ACTG1/PLPP3/GJA1/TFPI/ANO6/ARFGEF1/FERMT1/CLDN4/C1QTNF1/HMGB1/CAV1/ANXA2/OCLN 16 GO:0050679 positive regulation of epithelial cell proliferation 22/1115 207/18722 0.0061035932145748 0.0521393346761837 EGFR/LAMC1/LAMB1/NRP2/GRN/NRP1/RTN4/B4GALT1/TGFBR1/TCF7L2/RICTOR/ADAM17/BMPR2/EMC10/AKT3/HMGB1/CFLAR/CCND1/BMPR1A/FGFR2/ERBB2/CTNNB1 22 GO:0043487 regulation of RNA stability 19/1115 170/18722 0.00612717456989031 0.052257164582499 NPM1/ZFP36L1/YBX1/TNRC6B/ROCK1/CNOT6L/PUM2/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/RC3H1/HNRNPD/FUS/YBX3 19 GO:0048705 skeletal system morphogenesis 23/1115 220/18722 0.00624862105638807 0.0532079550559106 FBN2/LRP5/GLG1/NIPBL/BMP7/ANKRD11/TRIP11/DLG1/LTBP3/TGFBR1/RYK/CHST11/TRPV4/GLI3/BMPR2/SMAD2/SETD2/MAPK14/TSKU/ARID5B/FGFR2/DHRS3/CTNNB1 23 GO:0006656 phosphatidylcholine biosynthetic process 6/1115 29/18722 0.0064098113181212 0.0541487066890017 SLC44A2/CDS1/SLC44A1/ACSL3/LPCAT3/GPAT4 6 GO:0022011 myelination in peripheral nervous system 6/1115 29/18722 0.0064098113181212 0.0541487066890017 DAG1/ITGB4/DICER1/NF1/PLEC/SOD1 6 GO:0032292 peripheral nervous system axon ensheathment 6/1115 29/18722 0.0064098113181212 0.0541487066890017 DAG1/ITGB4/DICER1/NF1/PLEC/SOD1 6 GO:0034067 protein localization to Golgi apparatus 6/1115 29/18722 0.0064098113181212 0.0541487066890017 VPS13C/GCC2/RAB6A/VPS13A/ARL5B/OBSL1 6 GO:2000406 positive regulation of T cell migration 6/1115 29/18722 0.0064098113181212 0.0541487066890017 APP/DOCK8/ADAM10/ADAM17/WNK1/RHOA 6 GO:0002573 myeloid leukocyte differentiation 22/1115 208/18722 0.0064536981182859 0.0544210834006546 FBN1/CDK6/ITGB8/APP/ZFP36L1/CD74/ATP6AP1/TFRC/IREB2/KLF10/RBPJ/TMEM64/FOXP1/MAPK14/SH3PXD2A/ITGB6/TLR3/ANXA2/GPC3/CTNNB1/FASN/LTBR 22 GO:0042491 inner ear auditory receptor cell differentiation 7/1115 38/18722 0.00648120369862711 0.0544210834006546 MCOLN3/JAG1/RBPJ/MYO7A/ESRP1/MYO6/SOD1 7 GO:0097242 amyloid-beta clearance 7/1115 38/18722 0.00648120369862711 0.0544210834006546 LRP2/LRP1/MME/IGF1R/CLTC/ROCK1/INSR 7 GO:0048562 embryonic organ morphogenesis 28/1115 285/18722 0.00648282619269831 0.0544210834006546 FBN1/FBN2/EFEMP1/NIPBL/BMP7/ATP6V1B1/DLG1/FOLR1/TGFBR1/FZD5/RPL38/CHST11/GLI3/MIB1/MYO7A/NAGLU/SMAD2/SETD2/FZD6/AHI1/MYO6/PHACTR4/PKD2/FGFR2/FZD3/PTK7/CTNNB1/SOD1 28 GO:0048640 negative regulation of developmental growth 14/1115 112/18722 0.00668188831660533 0.0560040843365084 SEMA6D/NRP1/SEMA6A/LGMN/SLC6A4/ADRB1/RTN4/SEMA3F/GJA1/RYK/SEMA4B/JARID2/WWC2/SEMA7A 14 GO:0032516 positive regulation of phosphoprotein phosphatase activity 5/1115 21/18722 0.00678276772877026 0.0565831201623507 SLC39A10/CALM1/HSP90AB1/PPP1R12A/PPP1R15B 5 GO:0038083 peptidyl-tyrosine autophosphorylation 5/1115 21/18722 0.00678276772877026 0.0565831201623507 EGFR/IQGAP1/IGF1R/DDR1/CAV1 5 GO:0045056 transcytosis 5/1115 21/18722 0.00678276772877026 0.0565831201623507 LRP2/LRP1/IGF1R/CLTC/USO1 5 GO:0050772 positive regulation of axonogenesis 11/1115 79/18722 0.00695267599610469 0.057779109126597 LRP1/GOLGA4/NRP1/MACF1/PLXNB1/CDKL5/PLXNB2/PLXNA1/FN1/BMPR2/SEMA7A 11 GO:0086065 cell communication involved in cardiac conduction 9/1115 58/18722 0.00695860033122342 0.057779109126597 DSC2/GJA1/CALM1/DSG2/GJA5/ATP1A1/DSP/PKP2/CAV1 9 GO:2000649 regulation of sodium ion transmembrane transporter activity 9/1115 58/18722 0.00695860033122342 0.057779109126597 UTRN/ANK3/SLC9A1/ACTN4/KIF5B/GPD1L/DMD/WNK1/STOM 9 GO:0007272 ensheathment of neurons 16/1115 136/18722 0.00702106130197777 0.0580270066428163 DAG1/ITGB4/DICER1/CTSC/NF1/HEXB/PLEC/DLG1/GPC1/B4GALT5/NCSTN/DEGS1/CMTM8/ERBB2/CTNNB1/SOD1 16 GO:0008366 axon ensheathment 16/1115 136/18722 0.00702106130197777 0.0580270066428163 DAG1/ITGB4/DICER1/CTSC/NF1/HEXB/PLEC/DLG1/GPC1/B4GALT5/NCSTN/DEGS1/CMTM8/ERBB2/CTNNB1/SOD1 16 GO:0045727 positive regulation of translation 16/1115 136/18722 0.00702106130197777 0.0580270066428163 NPM1/RPL5/PRKDC/PLXNB2/RPS4X/RPL26/LARP4/RPS9/DNAJC3/DHX36/AGO2/EIF5A/ERBB2/HNRNPD/RHOA/YBX3 16 GO:0051384 response to glucocorticoid 17/1115 148/18722 0.00705484178102938 0.0582160746041976 EGFR/ATP2B1/ANXA1/AGL/ZFP36L1/CALM1/GLB1/SERPINF1/NR3C1/GSTP1/UBE2L3/HMGB1/CFLAR/CCND1/REST/ISL1/RHOA 17 GO:0006605 protein targeting 30/1115 314/18722 0.00731751836055026 0.0602904792082991 TCAF1/LMAN1/NACA/SEC62/ANK3/MYO1C/VPS13C/SCARB2/SEC63/SEC61A1/GCC2/GNPTAB/SPCS3/FZD5/LAMP2/VPS13A/HSPA5/UBE2L3/PRKCI/NPEPPS/TRAM1/SSR1/ZDHHC20/SIL1/ZDHHC21/SREBF2/TRAK2/STOM/TRAM2/ERBB2 30 GO:0045665 negative regulation of neuron differentiation 10/1115 69/18722 0.00744214781646422 0.0611286572186192 PBX1/SLC6A4/APP/BMP7/JAG1/GLI3/MIB1/REST/ISL1/RHOA 10 GO:1901224 positive regulation of NIK/NF-kappaB signaling 10/1115 69/18722 0.00744214781646422 0.0611286572186192 EGFR/APP/NFAT5/RPS3/ACTN4/TRIM44/HMGB1/TLR3/RC3H1/RHOA 10 GO:0010463 mesenchymal cell proliferation 7/1115 39/18722 0.00750190393839068 0.0615248312243745 LRP5/BMP7/NFIB/BMPR1A/FGFR2/GPC3/CTNNB1 7 GO:0030100 regulation of endocytosis 22/1115 211/18722 0.00760419754644767 0.061939878284266 LRP1/ITGAV/AAK1/CALM1/ANO6/STON1/ROCK1/SMPD1/SCYL2/MIB1/WASL/DNAJC6/CLN3/AHI1/CAV1/APPL1/RAB31/INSR/PPP3CA/MKLN1/ANXA2/GPC3 22 GO:0006884 cell volume homeostasis 6/1115 30/18722 0.00761655663065015 0.061939878284266 NPM1/ANO6/KCNN4/CLCN3/TRPV4/CLN3 6 GO:0060674 placenta blood vessel development 6/1115 30/18722 0.00761655663065015 0.061939878284266 SPINT1/ITGB8/FZD5/NR2F2/RBPJ/PKD2 6 GO:0061384 heart trabecula morphogenesis 6/1115 30/18722 0.00761655663065015 0.061939878284266 TGFBR3/BMP7/ADAMTS1/TGFBR1/RBPJ/BMPR1A 6 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 6/1115 30/18722 0.00761655663065015 0.061939878284266 ATF6/UFL1/HSPA5/TMEM33/PPP1R15B/WFS1 6 GO:0006885 regulation of pH 12/1115 91/18722 0.00762946556266213 0.061939878284266 GRN/ATP6V1B1/SLC9A1/ATP6AP1/TMEM106B/SLC4A2/CLN5/TTPA/CLCN3/CLN3/EDNRB/ATP6V0A1 12 GO:0048145 regulation of fibroblast proliferation 11/1115 80/18722 0.00763923336099249 0.061939878284266 FTH1/CDK6/MIF/CD74/NF1/PRKDC/FN1/GSTP1/PDGFD/ANXA2/CTNNB1 11 GO:0008217 regulation of blood pressure 20/1115 186/18722 0.00764532305475395 0.061939878284266 ATP2B1/MME/LRP5/ADRB1/GJA1/ENPEP/P2RX4/LNPEP/GJA5/NR2F2/ATP1A1/WNK1/F11R/BMPR2/NISCH/EDNRB/ERAP1/NAV2/RHOA/SOD1 20 GO:0045785 positive regulation of cell adhesion 39/1115 437/18722 0.00772324513382998 0.0619471072312271 ITGA6/DAG1/CD46/ADGRG1/IL6ST/ANXA1/UTRN/ITGAV/CDK6/IQGAP1/NRP1/DPP4/PLPP3/CD74/ZFHX3/GCNT2/NFAT5/ANK3/RPS3/DOCK8/BMP7/CCDC80/FN1/ROCK1/CD47/TFRC/P4HB/FERMT1/S100A10/GLI3/F11R/VAV3/HMGB1/CAV1/PPP3CA/CYTH3/ATM/ERBB2/RHOA 39 GO:0032984 protein-containing complex disassembly 23/1115 224/18722 0.0077249133304527 0.0619471072312271 IGF1R/RPL23/CFL1/SCIN/CALM1/SPTBN1/ADD3/TAOK1/ATP2A2/SPTAN1/SNX14/LAMP2/KIF5B/ARID1A/SMARCC1/TRPV4/DNAJC6/CLN3/CAMSAP2/INSR/EIF5A/VMP1/DSTN 23 GO:0006465 signal peptide processing 4/1115 14/18722 0.00773903737089875 0.0619471072312271 FURIN/SPCS3/CLN5/HM13 4 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 4/1115 14/18722 0.00773903737089875 0.0619471072312271 KANK1/FBLN1/ACTN4/EFNA5 4 GO:0070141 response to UV-A 4/1115 14/18722 0.00773903737089875 0.0619471072312271 EGFR/MME/OPN3/CCND1 4 GO:0072531 pyrimidine-containing compound transmembrane transport 4/1115 14/18722 0.00773903737089875 0.0619471072312271 SLC19A3/SLC28A2/SLC25A36/SLC29A1 4 GO:0099188 postsynaptic cytoskeleton organization 4/1115 14/18722 0.00773903737089875 0.0619471072312271 ACTG1/PPP1R9A/ACTB/WASF2 4 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/1115 14/18722 0.00773903737089875 0.0619471072312271 KANK1/FBLN1/ACTN4/EFNA5 4 GO:0046324 regulation of glucose import 9/1115 59/18722 0.00778838505845599 0.0621836648871612 PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/INSR/OCLN/GPC3 9 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 14/1115 114/18722 0.00779417966870043 0.0621836648871612 TGFBR3/BMP7/HSP90AB1/TGFBR1/FERMT1/RBPJ/ADAM17/BMPR2/SMAD2/BMPR1A/CREBBP/GPC3/ACVR2B/CDKN1C 14 GO:0031334 positive regulation of protein-containing complex assembly 24/1115 237/18722 0.00780353164907249 0.0621836648871612 AKAP9/MET/PFN1/IQGAP2/ABCA1/CLIP1/SCIN/RPS3/MYO1C/DLG1/MPP7/TFRC/RICTOR/NCKAP1/FERMT1/WASL/ARPC3/ASAP1/ABI2/OCLN/ATM/HSPA1A/RHOA/WASF2 24 GO:0048639 positive regulation of developmental growth 19/1115 174/18722 0.00782325521910526 0.0622479278909135 LRP1/GOLGA4/NRP1/MACF1/NIPBL/TGFBR3/PRKDC/CDKL5/FN1/RBPJ/BMPR2/CELF1/SEMA7A/MAPK14/BMPR1A/ITSN2/INSR/FGFR2/YBX3 19 GO:0006692 prostanoid metabolic process 8/1115 49/18722 0.00787058425227694 0.0623457705087635 ANXA1/MIF/CD74/PTGES3/ATP6V1B1/GSTP1/ACOX1/HPGD 8 GO:0006693 prostaglandin metabolic process 8/1115 49/18722 0.00787058425227694 0.0623457705087635 ANXA1/MIF/CD74/PTGES3/ATP6V1B1/GSTP1/ACOX1/HPGD 8 GO:0034332 adherens junction organization 8/1115 49/18722 0.00787058425227694 0.0623457705087635 CDH1/PLEC/ADAM10/DLG5/MTSS1/DSP/ACTB/CTNNB1 8 GO:0051494 negative regulation of cytoskeleton organization 18/1115 162/18722 0.00795947193722693 0.0629564750708957 MET/KANK1/PFN1/NPM1/SCIN/SPTBN1/ADD3/ARFGEF1/TAOK1/SPTAN1/ARHGAP28/PPP1R9A/KANK4/PPFIA1/F11R/TMSB4X/CAMSAP2/WASF2 18 GO:0002027 regulation of heart rate 13/1115 103/18722 0.00810156553848035 0.0639855893638263 AKAP9/DSC2/ADRB1/CALM1/DSG2/YWHAE/ATP2A2/GPD1L/DMD/DSP/PKP2/CAV1/ISL1 13 GO:0010001 glial cell differentiation 23/1115 225/18722 0.00813541243071413 0.0641580014292212 EGFR/SPINT1/LRP1/DAG1/IL6ST/ITGB4/GRN/CDK6/APP/DICER1/NF1/ERBB3/PLEC/GPC1/B4GALT5/GSTP1/NCSTN/NFIB/GLI3/ERBB2/CTNNB1/RHOA/SOD1 23 GO:0034504 protein localization to nucleus 28/1115 290/18722 0.0081499953929248 0.0641782085587397 CDH1/RPL23/NPM1/MAGED1/BMP7/TPR/HSP90AB1/UBR5/RANBP2/YWHAE/TNPO1/TFRC/FERMT1/KPNB1/LATS2/GLI3/IPO7/MAPK14/OSBPL8/RAN/APPL1/RANBP17/TOR1AIP2/PPP3CA/SKP1/MAVS/IPO9/CCT3 28 GO:0060415 muscle tissue morphogenesis 10/1115 70/18722 0.008231711814342 0.0646310432011352 LRP2/TGFBR3/TGFBR1/RBPJ/DSP/LY6E/PKP2/BMPR1A/FGFR2/ISL1 10 GO:0070830 bicellular tight junction assembly 10/1115 70/18722 0.008231711814342 0.0646310432011352 GJA1/MYO1C/DLG1/MPP7/ROCK1/FZD5/F11R/CLDN4/RAB13/OCLN 10 GO:0032727 positive regulation of interferon-alpha production 5/1115 22/18722 0.00835474061830653 0.0651047395569126 DHX36/SETD2/HMGB1/TLR3/MAVS 5 GO:0045048 protein insertion into ER membrane 5/1115 22/18722 0.00835474061830653 0.0651047395569126 EMC1/TRAM1/CCDC47/EMC10/TRAM2 5 GO:0071359 cellular response to dsRNA 5/1115 22/18722 0.00835474061830653 0.0651047395569126 COLEC12/NPM1/CAV1/TLR3/MAVS 5 GO:0099563 modification of synaptic structure 5/1115 22/18722 0.00835474061830653 0.0651047395569126 PFN1/MYH10/CLN3/REST/RHOA 5 GO:2000114 regulation of establishment of cell polarity 5/1115 22/18722 0.00835474061830653 0.0651047395569126 KANK1/DOCK8/ARFGEF1/ROCK1/RICTOR 5 GO:0001942 hair follicle development 11/1115 81/18722 0.00837740327319703 0.0651047395569126 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ/FZD6/ZDHHC21/FGFR2/FZD3/CTNNB1 11 GO:0048144 fibroblast proliferation 11/1115 81/18722 0.00837740327319703 0.0651047395569126 FTH1/CDK6/MIF/CD74/NF1/PRKDC/FN1/GSTP1/PDGFD/ANXA2/CTNNB1 11 GO:0071675 regulation of mononuclear cell migration 14/1115 115/18722 0.00840284217873593 0.0652075209189987 LGMN/APP/ANO6/DOCK8/ADAM10/CD47/ADAM17/WNK1/TRPV4/MIA3/WASL/HMGB1/PDGFD/RHOA 14 GO:0071241 cellular response to inorganic substance 23/1115 226/18722 0.00856353825088069 0.066252273243887 EGFR/CDH1/IQGAP1/LGMN/APP/ATRX/SERPINF1/ANK3/P2RX4/SYT7/HSPA5/AOC1/ADCY7/SMPD1/NCSTN/MTR/WNK1/DDI2/CFLAR/PKD2/HNRNPD/FUS/SOD1 23 GO:0006575 cellular modified amino acid metabolic process 20/1115 188/18722 0.00857015566413274 0.066252273243887 PCYOX1/SLC19A1/CTSB/SERINC1/ARL6IP5/FOLR1/GSTP1/SERINC3/CROT/GCNT4/CPT2/OSBPL8/SLC16A2/LPCAT3/CLIC3/ALDH4A1/IDH1/GGH/SERINC2/SOD1 20 GO:2001236 regulation of extrinsic apoptotic signaling pathway 17/1115 151/18722 0.00857469953390633 0.066252273243887 ITGA6/ITGAV/NRP1/BIRC6/RB1CC1/GSTP1/PHIP/TGFBR1/TCF7L2/IFI6/PDIA3/SIAH2/CFLAR/CAV1/FEM1B/HSPA1A/LTBR 17 GO:0044275 cellular carbohydrate catabolic process 7/1115 40/18722 0.00863664717740712 0.0665383250796199 AGL/GAA/RB1CC1/SCARB2/TPI1/GUSB/HMGB1 7 GO:1901998 toxin transport 7/1115 40/18722 0.00863664717740712 0.0665383250796199 NRP1/ADAM10/HSPA5/ANTXR2/ATP6V0A1/DNAJA1/CCT3 7 GO:0006893 Golgi to plasma membrane transport 9/1115 60/18722 0.00869144405944181 0.0666718675766664 GOLGA4/MACF1/ANK3/SPTBN1/KRT18/LYPLA1/CLN3/ACSL3/RAB31 9 GO:0042306 regulation of protein import into nucleus 9/1115 60/18722 0.00869144405944181 0.0666718675766664 CDH1/TPR/HSP90AB1/UBR5/FERMT1/GLI3/MAPK14/RAN/MAVS 9 GO:0061951 establishment of protein localization to plasma membrane 9/1115 60/18722 0.00869144405944181 0.0666718675766664 GOLGA4/MACF1/ANK3/SPTBN1/KRT18/LYPLA1/CLN3/ACSL3/RAB31 9 GO:0045862 positive regulation of proteolysis 34/1115 372/18722 0.0087436857533123 0.0669763819755156 GRN/FBLN1/LGMN/APP/CTSC/ASPH/CTSD/HECTD1/RPS3/ARL6IP5/FURIN/ENO1/FN1/RNF217/ZYG11B/NCSTN/TMEM259/PIAS1/CLDN4/HMGB1/RNF19A/TMTC3/CFLAR/CAV1/DDA1/CSNK1A1/LPCAT3/REST/CYFIP2/CYCS/CDC20/HSPA1A/HSPE1/RHOA 34 GO:0006892 post-Golgi vesicle-mediated transport 13/1115 104/18722 0.00876922236827098 0.0670061477175703 GOLGA4/MACF1/ANK3/SPTBN1/SCAMP2/KRT18/VPS13C/VPS13A/MON2/LYPLA1/CLN3/ACSL3/RAB31 13 GO:0006403 RNA localization 21/1115 201/18722 0.00877267227094617 0.0670061477175703 HNRNPA1/NPM1/ZFP36L1/YBX1/TPR/MYO1C/SRSF3/RANBP2/SMG1/THOC2/LRPPRC/DHX36/SETD2/DCP2/HNRNPA2B1/RAN/RANBP17/EIF5A/ATM/CCT3/HNRNPA3 21 GO:0010634 positive regulation of epithelial cell migration 19/1115 176/18722 0.00880359825655164 0.0671463015596132 MET/NRP2/GRN/ANXA1/PFN1/NRP1/LGMN/RTN4/PLPP3/P2RX4/ADAM17/BMPR2/TMSB4X/HSPB1/FOXP1/EMC10/AKT3/HMGB1/CAPN7 19 GO:0045936 negative regulation of phosphate metabolic process 39/1115 441/18722 0.0089145490711704 0.0678955456362036 LRP1/LRP5/NPM1/FBLN1/PLPP3/BOD1L1/DYNLL1/NF1/PPIA/CALM1/PRKDC/PLEC/BMP7/GNAQ/YWHAE/NCOR1/GSTP1/ROCK1/NR2F2/SMPD1/GPD1L/PARP14/PKIB/DMD/C9orf72/LATS2/WNK1/DNAJC3/HSPB1/IPO7/CAV1/PPP1R15B/SUZ12/PIK3IP1/IBTK/DNAJA1/OCLN/PRDX3/CDKN1C 39 GO:0009306 protein secretion 33/1115 359/18722 0.0089346625028268 0.067951799291442 EGFR/LRP1/ANXA1/LRP5/WLS/ABCA1/CANX/DPP4/DYNLL1/PPIA/GJA1/FAM3B/EXPH5/SEL1L/P3H1/SYT7/KCNN4/GNPTAB/CCDC186/SLC16A1/TCF7L2/KIF5B/FRMD4A/MYH10/MIA3/PDIA4/SMAD2/RAB13/EFNA5/PPP3CA/REST/ISL1/RHBDF1 33 GO:0071711 basement membrane organization 6/1115 31/18722 0.00897873528441839 0.0680929938686219 DAG1/LAMB1/ITGB1/COL4A1/FERMT1/CAV1 6 GO:0090162 establishment of epithelial cell polarity 6/1115 31/18722 0.00897873528441839 0.0680929938686219 FAT1/FERMT1/FRMD4A/CYTH3/PTK7/RHOA 6 GO:0021782 glial cell development 14/1115 116/18722 0.00904847379248571 0.0685245412455052 EGFR/LRP1/DAG1/ITGB4/GRN/CDK6/APP/DICER1/NF1/PLEC/B4GALT5/GSTP1/NCSTN/SOD1 14 GO:0015748 organophosphate ester transport 16/1115 140/18722 0.00920502871779652 0.0696113998927983 ATP10D/ABCA1/SLC19A1/GJA1/ANO6/TMEM30A/SCARB2/KCNN4/CD47/SLC25A36/SLC29A1/PLEKHA8/OSBPL8/G6PC3/TMEM30B/ATP11B 16 GO:0010563 negative regulation of phosphorus metabolic process 39/1115 442/18722 0.00923512277644722 0.0697401987318978 LRP1/LRP5/NPM1/FBLN1/PLPP3/BOD1L1/DYNLL1/NF1/PPIA/CALM1/PRKDC/PLEC/BMP7/GNAQ/YWHAE/NCOR1/GSTP1/ROCK1/NR2F2/SMPD1/GPD1L/PARP14/PKIB/DMD/C9orf72/LATS2/WNK1/DNAJC3/HSPB1/IPO7/CAV1/PPP1R15B/SUZ12/PIK3IP1/IBTK/DNAJA1/OCLN/PRDX3/CDKN1C 39 GO:0035592 establishment of protein localization to extracellular region 33/1115 360/18722 0.00929350698223612 0.0700819686132184 EGFR/LRP1/ANXA1/LRP5/WLS/ABCA1/CANX/DPP4/DYNLL1/PPIA/GJA1/FAM3B/EXPH5/SEL1L/P3H1/SYT7/KCNN4/GNPTAB/CCDC186/SLC16A1/TCF7L2/KIF5B/FRMD4A/MYH10/MIA3/PDIA4/SMAD2/RAB13/EFNA5/PPP3CA/REST/ISL1/RHBDF1 33 GO:0043405 regulation of MAP kinase activity 19/1115 177/18722 0.00932957702235393 0.0702547414983747 EGFR/IQGAP1/FLT1/NF1/MAGED1/RPS3/BMP7/AKAP13/GSTP1/FZD5/SMPD1/DVL3/TAOK3/PDGFD/CAV1/CDK12/INSR/DNAJA1/ERBB2 19 GO:0006936 muscle contraction 32/1115 347/18722 0.00949018231846545 0.0712631271424571 AKAP9/ATP2B1/UTRN/DSC2/ATP2B4/GAA/ALDOA/ASPH/GJA1/CALM1/DSG2/P2RX4/ENO1/SLC9A1/DLG1/ATP2A2/ROCK1/GJA5/GPD1L/DMD/ATP1A1/TRPV4/DSP/PKP2/CAV1/ZDHHC21/EDNRB/MYOF/MYL6/PPP1R12B/RHOA/SOD1 32 GO:0070482 response to oxygen levels 32/1115 347/18722 0.00949018231846545 0.0712631271424571 MALAT1/SLC2A1/LDHA/HSP90B1/SLC6A4/ZFP36L1/DPP4/NF1/TGFBR3/BMP7/ITPR2/DNMT3A/SLC11A2/MDM4/ENO1/SLC9A1/ATP6AP1/P4HB/NPEPPS/CHCHD2/CPEB4/RBPJ/ADAM17/SLC29A1/PLOD1/CFLAR/CAV1/SLC2A8/REST/CAT/CREBBP/RHOA 32 GO:0044843 cell cycle G1/S phase transition 24/1115 241/18722 0.00951079909234709 0.0713176353287094 EGFR/ITGB1/ANXA1/CDK6/RPS6/ATP2B4/BRD4/PRKDC/BCAT1/RPL26/DLG1/ADAMTS1/SKP2/LATS2/ADAM17/PIAS1/JADE1/CCND1/APPL1/PKD2/PPP3CA/ANKRD17/ATM/CDKN3 24 GO:0046661 male sex differentiation 18/1115 165/18722 0.00955433734159849 0.071524690643466 LRP2/ADGRG1/LGR4/ATRX/SF1/PRDX4/TGFBR1/KDM5A/RHOBTB3/DHCR24/RAB13/CCND1/ARID5B/BMPR1A/TLR3/EIF2S2/CTNNB1/YBX3 18 GO:0022411 cellular component disassembly 39/1115 443/18722 0.00956520492965625 0.071524690643466 LAMC1/LRP1/IGF1R/RPL23/DICER1/CFL1/DPP4/SCIN/CALM1/SPTBN1/FURIN/ADAM10/VPS13C/ADD3/RB1CC1/TAOK1/ATP2A2/SPTAN1/SNX14/UFL1/TGFBR1/FZD5/LAMP2/KIF5B/ARID1A/VDAC1/SMARCC1/MMP15/TRPV4/DDR1/DNAJC6/CLN3/CAMSAP2/ATG9A/SREBF2/INSR/EIF5A/VMP1/DSTN 39 GO:0009755 hormone-mediated signaling pathway 20/1115 190/18722 0.00958338034543594 0.0715603743556398 LGR5/LGR4/PRLR/DDX17/BMP7/PTGES3/NR3C1/ESRRG/UBR5/NCOR1/UFL1/ARID1A/SKP2/LATS2/FOXP1/PAQR7/APPL1/ISL1/DNAJA1/RHOA 20 GO:0019080 viral gene expression 12/1115 94/18722 0.00981998713807595 0.0728974436789226 CANX/FURIN/MOGS/MAN2A1/PCBP2/SPCS3/RSF1/EIF3A/REST/MGAT1/TRIM13/MAN1B1 12 GO:1902414 protein localization to cell junction 12/1115 94/18722 0.00981998713807595 0.0728974436789226 DAG1/ACTG1/ADAM10/DLG5/DLG1/MPP7/CLSTN1/KIF5B/F11R/HSPB1/DSP/ACTB 12 GO:1990830 cellular response to leukemia inhibitory factor 12/1115 94/18722 0.00981998713807595 0.0728974436789226 NRP2/RPS16/SRSF3/RIF1/B3GNT2/TFRC/JARID2/RNMT/TLE4/ARID5B/BCAT2/NCL 12 GO:0050921 positive regulation of chemotaxis 16/1115 141/18722 0.00982760746324328 0.0728974436789226 MET/NRP1/LGMN/CD74/ANO6/P2RX4/ADAM10/TPBG/ADAM17/WNK1/TRPV4/BMPR2/TMSB4X/HSPB1/HMGB1/PDGFD 16 GO:0035265 organ growth 19/1115 178/18722 0.00988049641331477 0.0728974436789226 PSAP/SLC6A4/GJA1/TGFBR3/AKAP13/TGFBR1/JARID2/RBPJ/LATS2/WWC2/SMAD2/LY6E/MAPK14/TSKU/BMPR1A/FGFR2/PLAG1/SOD1/YBX3 19 GO:0009612 response to mechanical stimulus 22/1115 216/18722 0.00988994031310933 0.0728974436789226 EGFR/DAG1/SLC2A1/SLC38A2/GJA1/PLEC/TMEM150C/USP53/SLC9A1/MAP3K2/MEIS2/SLC1A3/DMD/ATP1A1/TRPV4/F11R/MAPK14/PKD2/TLR3/CTNNB1/LTBR/RHOA 22 GO:0048286 lung alveolus development 7/1115 41/18722 0.0098924629473823 0.0728974436789226 PTGES3/MAN2A1/MAN1A2/LTBP3/BMPR2/ITGB6/FGFR2 7 GO:0001736 establishment of planar polarity 10/1115 72/18722 0.0100023725039622 0.0728974436789226 ZNRF3/DAAM1/RYK/DVL3/FZD6/FZD3/SMURF2/PTK7/GPC3/RHOA 10 GO:0005977 glycogen metabolic process 10/1115 72/18722 0.0100023725039622 0.0728974436789226 IL6ST/AGL/GAA/PTGES3/PHKB/RB1CC1/EPM2AIP1/SORBS1/HMGB1/INSR 10 GO:0007164 establishment of tissue polarity 10/1115 72/18722 0.0100023725039622 0.0728974436789226 ZNRF3/DAAM1/RYK/DVL3/FZD6/FZD3/SMURF2/PTK7/GPC3/RHOA 10 GO:0030330 DNA damage response, signal transduction by p53 class mediator 10/1115 72/18722 0.0100023725039622 0.0728974436789226 NPM1/MIF/ATRX/CD74/RPL26/MDM4/MYO6/ATM/USP10/PLA2R1 10 GO:0045104 intermediate filament cytoskeleton organization 8/1115 51/18722 0.0100113598038558 0.0728974436789226 MACF1/DST/PLEC/KRT18/DSP/PKP2/CSNK1A1/SOD1 8 GO:0046850 regulation of bone remodeling 8/1115 51/18722 0.0100113598038558 0.0728974436789226 EGFR/NF1/SYT7/LTBP3/ATP6AP1/TFRC/SUCO/TMEM64 8 GO:0060043 regulation of cardiac muscle cell proliferation 8/1115 51/18722 0.0100113598038558 0.0728974436789226 GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 8 GO:0010452 histone H3-K36 methylation 4/1115 15/18722 0.0100628237481487 0.0728974436789226 ASH1L/BRD4/NSD1/SETD2 4 GO:0045475 locomotor rhythm 4/1115 15/18722 0.0100628237481487 0.0728974436789226 ZFHX3/NCOR1/NAGLU/NCOA2 4 GO:0098760 response to interleukin-7 4/1115 15/18722 0.0100628237481487 0.0728974436789226 YBX1/P4HB/PDIA3/HMGB1 4 GO:0098761 cellular response to interleukin-7 4/1115 15/18722 0.0100628237481487 0.0728974436789226 YBX1/P4HB/PDIA3/HMGB1 4 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 4/1115 15/18722 0.0100628237481487 0.0728974436789226 UFL1/HSPA5/PPP1R15B/WFS1 4 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/1115 15/18722 0.0100628237481487 0.0728974436789226 ZFP36L1/TNRC6B/DHX36/AGO2 4 GO:1901660 calcium ion export 4/1115 15/18722 0.0100628237481487 0.0728974436789226 ATP2B1/ATP2B4/CALM1/YWHAE 4 GO:1904380 endoplasmic reticulum mannose trimming 4/1115 15/18722 0.0100628237481487 0.0728974436789226 EDEM3/AMFR/TRIM13/MAN1B1 4 GO:0051236 establishment of RNA localization 18/1115 166/18722 0.0101393748228794 0.0731198048165328 HNRNPA1/NPM1/ZFP36L1/YBX1/TPR/MYO1C/SRSF3/RANBP2/SMG1/THOC2/LRPPRC/SETD2/HNRNPA2B1/RAN/RANBP17/EIF5A/ATM/HNRNPA3 18 GO:0021884 forebrain neuron development 5/1115 23/18722 0.0101619957246427 0.0731198048165328 NRP2/NRP1/SCYL2/FGFR2/RAPGEF2 5 GO:0030325 adrenal gland development 5/1115 23/18722 0.0101619957246427 0.0731198048165328 PBX1/NF1/SMAD2/LY6E/ARID5B 5 GO:2000737 negative regulation of stem cell differentiation 5/1115 23/18722 0.0101619957246427 0.0731198048165328 N4BP2L2/JAG1/CDK12/REST/CDK13 5 GO:2000810 regulation of bicellular tight junction assembly 5/1115 23/18722 0.0101619957246427 0.0731198048165328 GJA1/MYO1C/ROCK1/FZD5/F11R 5 GO:0046620 regulation of organ growth 13/1115 106/18722 0.0102335280808342 0.0735354056844872 SLC6A4/GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/LATS2/WWC2/MAPK14/BMPR1A/FGFR2/SOD1/YBX3 13 GO:0051098 regulation of binding 33/1115 363/18722 0.0104419828167499 0.0744943360308778 LRP1/MET/PTPRF/NRP1/APP/CALM1/TGFBR3/HSP90AB1/ATP2A2/C4orf3/ARHGAP28/ROCK1/NSD1/TGFBR1/TCF7L2/RSF1/CLN5/AMFR/CCPG1/C9orf72/S100A10/TMSB4X/SMAD2/HMGB1/CAV1/RAN/CSNK1A1/ACTB/PPP3CA/ANXA2/ISL1/RAPGEF2/CTNNB1 33 GO:1903313 positive regulation of mRNA metabolic process 14/1115 118/18722 0.0104566264241961 0.0744943360308778 ZFP36L1/TNRC6B/ROCK1/CNOT6L/CELF1/DHX36/DCP2/PUM1/AGO2/TRA2B/MOV10/NCL/RC3H1/HNRNPD 14 GO:0006941 striated muscle contraction 19/1115 179/18722 0.0104571703351225 0.0744943360308778 AKAP9/DSC2/GAA/ALDOA/GJA1/CALM1/DSG2/P2RX4/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/TRPV4/DSP/PKP2/CAV1 19 GO:0007009 plasma membrane organization 16/1115 142/18722 0.0104830956815093 0.0744943360308778 ANO6/ANK3/PLEC/SPTBN1/ATP2A2/FOLR1/SYT7/SMPD1/DEGS1/MTSS1/WASL/CLN3/CAV1/ASAP1/MYOF/SOD1 16 GO:0014044 Schwann cell development 6/1115 32/18722 0.0105065059058346 0.0744943360308778 DAG1/ITGB4/DICER1/NF1/PLEC/SOD1 6 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 6/1115 32/18722 0.0105065059058346 0.0744943360308778 TGFBR3/HSP90AB1/FERMT1/ADAM17/CREBBP/CDKN1C 6 GO:0033687 osteoblast proliferation 6/1115 32/18722 0.0105065059058346 0.0744943360308778 ITGAV/LRP5/PLXNB1/FGFR2/ATRAID/RHOA 6 GO:0060914 heart formation 6/1115 32/18722 0.0105065059058346 0.0744943360308778 LRP2/FOLR1/RBPJ/BMPR1A/ISL1/CTNNB1 6 GO:0071875 adrenergic receptor signaling pathway 6/1115 32/18722 0.0105065059058346 0.0744943360308778 ADRB1/ATP2B4/AKAP13/ZDHHC21/LMBRD2/RAPGEF2 6 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 6/1115 32/18722 0.0105065059058346 0.0744943360308778 TGFBR3/HSP90AB1/FERMT1/ADAM17/CREBBP/CDKN1C 6 GO:0006979 response to oxidative stress 39/1115 446/18722 0.0106146004060266 0.0751609437238408 EGFR/MET/ANXA1/LDHA/PRDX1/APP/PPIA/RPS3/BMP7/ARL6IP5/PRDX4/GPX3/ATP2A2/NET1/GSTP1/P4HB/CHCHD2/HSPB1/DHCR24/CHD6/GPX8/SCARA3/NFE2L1/PTPRK/RRM2B/PDGFD/PPP1R15B/OXR1/PKD2/TRA2B/REST/IDH1/CAT/CTNNB1/HSPA1A/PLA2R1/PRDX3/SOD1/PSMB5 39 GO:1990823 response to leukemia inhibitory factor 12/1115 95/18722 0.0106493025320645 0.0753067896936324 NRP2/RPS16/SRSF3/RIF1/B3GNT2/TFRC/JARID2/RNMT/TLE4/ARID5B/BCAT2/NCL 12 GO:0048488 synaptic vesicle endocytosis 9/1115 62/18722 0.01073301391526 0.0755983658226557 CANX/ACTG1/CALM1/KIAA1109/STON1/ROCK1/DNAJC6/ITSN2/ACTB 9 GO:0060675 ureteric bud morphogenesis 9/1115 62/18722 0.01073301391526 0.0755983658226557 LAMA5/LGR4/PBX1/MAGED1/DLG1/GLI3/PKD2/GPC3/CTNNB1 9 GO:0140238 presynaptic endocytosis 9/1115 62/18722 0.01073301391526 0.0755983658226557 CANX/ACTG1/CALM1/KIAA1109/STON1/ROCK1/DNAJC6/ITSN2/ACTB 9 GO:0031960 response to corticosteroid 18/1115 167/18722 0.0107526289949134 0.0756367407165254 EGFR/ATP2B1/ANXA1/AGL/ZFP36L1/CALM1/GLB1/SERPINF1/NR3C1/GSTP1/UBE2L3/HMGB1/CFLAR/CCND1/RPL27/REST/ISL1/RHOA 18 GO:0006835 dicarboxylic acid transport 11/1115 84/18722 0.0109264980171886 0.0761522844800308 LRP2/SLC26A2/ITGB1/SLC19A1/GJA1/SLC1A5/ARL6IP5/FOLR1/SLC1A3/SLC13A3/RAB3GAP1 11 GO:0006970 response to osmotic stress 11/1115 84/18722 0.0109264980171886 0.0761522844800308 EGFR/SLC2A1/ZFP36L1/NFAT5/HSP90AB1/TRPV4/CLN3/PKD2/TLR3/TSC22D2/YBX3 11 GO:0022404 molting cycle process 11/1115 84/18722 0.0109264980171886 0.0761522844800308 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ/FZD6/ZDHHC21/FGFR2/FZD3/CTNNB1 11 GO:0022405 hair cycle process 11/1115 84/18722 0.0109264980171886 0.0761522844800308 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ/FZD6/ZDHHC21/FGFR2/FZD3/CTNNB1 11 GO:0045445 myoblast differentiation 11/1115 84/18722 0.0109264980171886 0.0761522844800308 MBNL3/ZFP36L1/PLEC/DDX17/MBNL1/JAG1/TCF7L2/RBPJ/MAPK14/REST/ISL1 11 GO:0005996 monosaccharide metabolic process 25/1115 257/18722 0.0109331186553939 0.0761522844800308 GAPDH/SLC2A1/LRP5/GAA/ALDOA/GLB1/RANBP2/B4GALT1/MAN2A1/ENO1/DDB1/TPI1/SLC35B4/FUCA1/EPM2AIP1/SORBS1/NISCH/C1QTNF1/UXS1/HMGB1/SOGA1/NCOA2/MAPK14/G6PC3/INSR 25 GO:0006073 cellular glucan metabolic process 10/1115 73/18722 0.0109896566366439 0.0761522844800308 IL6ST/AGL/GAA/PTGES3/PHKB/RB1CC1/EPM2AIP1/SORBS1/HMGB1/INSR 10 GO:0035924 cellular response to vascular endothelial growth factor stimulus 10/1115 73/18722 0.0109896566366439 0.0761522844800308 NRP2/ANXA1/FLT1/NRP1/SEMA6A/ATP2B4/MYO1C/GAB1/HSPB1/MAPK14 10 GO:0042274 ribosomal small subunit biogenesis 10/1115 73/18722 0.0109896566366439 0.0761522844800308 NPM1/RPS6/RPS8/RPS16/PRKDC/RPS17/RPS21/RPS25/RPSA/RPL38 10 GO:0044042 glucan metabolic process 10/1115 73/18722 0.0109896566366439 0.0761522844800308 IL6ST/AGL/GAA/PTGES3/PHKB/RB1CC1/EPM2AIP1/SORBS1/HMGB1/INSR 10 GO:0099518 vesicle cytoskeletal trafficking 10/1115 73/18722 0.0109896566366439 0.0761522844800308 MYO1C/ACTN4/CCDC186/DYNC1H1/KIF5B/WASL/MYO7A/CLN3/TRAK2/MYO6 10 GO:1903364 positive regulation of cellular protein catabolic process 17/1115 155/18722 0.0109970802274028 0.0761522844800308 LRP2/LRP1/CTSC/RNF128/HECTD1/RNF217/ZYG11B/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/FBXL5/CSNK1A1/CDC20/HSPA1A 17 GO:0042303 molting cycle 13/1115 107/18722 0.0110337021966994 0.0762081966729338 EGFR/LAMA5/LGR5/LGR4/NIPBL/FERMT1/RBPJ/FZD6/TSKU/ZDHHC21/FGFR2/FZD3/CTNNB1 13 GO:0042633 hair cycle 13/1115 107/18722 0.0110337021966994 0.0762081966729338 EGFR/LAMA5/LGR5/LGR4/NIPBL/FERMT1/RBPJ/FZD6/TSKU/ZDHHC21/FGFR2/FZD3/CTNNB1 13 GO:0045861 negative regulation of proteolysis 32/1115 351/18722 0.0111077270969567 0.0766203552592404 GAPDH/SPINT1/CRIM1/LRP1/ITIH5/APLP2/GLG1/RPL23/RPL5/APP/TFPI/SERPINF1/FURIN/HSP90AB1/USP25/USP47/BIRC6/ROCK1/IFI6/SMARCC1/SIAH2/DHCR24/CLN3/CAST/XIAP/ANXA2/SERPINB9/GPC3/EIF3H/BIRC5/PRDX3/SERPINB1 32 GO:0030282 bone mineralization 14/1115 119/18722 0.011222176623093 0.0770709406376664 FBN2/ATP2B1/LGR4/ANO6/BMP7/ANKH/LTBP3/KLF10/BMPR2/BMPR1A/FGFR2/GPC3/ACVR2B/ATRAID 14 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 8/1115 52/18722 0.0112307907503473 0.0770709406376664 PLPP3/COPA/RAB6A/ERGIC2/TMEM115/TAPBP/ARF4/ARF5 8 GO:0010718 positive regulation of epithelial to mesenchymal transition 8/1115 52/18722 0.0112307907503473 0.0770709406376664 GCNT2/BMP7/JAG1/TGFBR1/TCF7L2/SMAD2/ISL1/CTNNB1 8 GO:0045103 intermediate filament-based process 8/1115 52/18722 0.0112307907503473 0.0770709406376664 MACF1/DST/PLEC/KRT18/DSP/PKP2/CSNK1A1/SOD1 8 GO:0014912 negative regulation of smooth muscle cell migration 7/1115 42/18722 0.0112763082165354 0.0770860557849969 LRP1/SEMA6D/GNA12/GSTP1/S1PR2/BMPR1A/RHOA 7 GO:0045047 protein targeting to ER 7/1115 42/18722 0.0112763082165354 0.0770860557849969 SEC62/SEC63/SEC61A1/SPCS3/HSPA5/TRAM1/TRAM2 7 GO:0051452 intracellular pH reduction 7/1115 42/18722 0.0112763082165354 0.0770860557849969 GRN/TMEM106B/CLN5/TTPA/CLCN3/CLN3/ATP6V0A1 7 GO:0099173 postsynapse organization 18/1115 168/18722 0.0113950197082906 0.077797967036526 NRP2/NRP1/IGF1R/LGMN/ACTG1/CFL1/SEMA3F/CDKL5/ADAM10/DLG1/PPP1R9A/WASL/DHX36/ACTB/INSR/ABI2/ARF4/WASF2 18 GO:0097191 extrinsic apoptotic signaling pathway 22/1115 219/18722 0.0115085508844925 0.0784727371293812 ITGA6/KRT8/ITGAV/NRP1/ERBB3/KRT18/SGPP1/BIRC6/RB1CC1/GSTP1/PHIP/TGFBR1/TCF7L2/IFI6/PDIA3/SIAH2/CFLAR/CAV1/FEM1B/TLR3/HSPA1A/LTBR 22 GO:0010769 regulation of cell morphogenesis involved in differentiation 12/1115 96/18722 0.0115316799320014 0.0785301519859123 KANK1/NRP1/FBLN1/PRKDC/CUX1/CDKL5/ACTN4/P4HB/S100A10/DHX36/OBSL1/EFNA5 12 GO:0007568 aging 31/1115 339/18722 0.0118131784542921 0.0803446621241602 COL4A2/LRP1/DAG1/ATP2B1/MME/CDK6/NPM1/CANX/APP/RPN2/MIF/CTSC/PRKDC/SERPINF1/YBX1/DNMT3A/SEC63/BAZ2B/PPP1R9A/AMFR/AKT3/TFCP2L1/MAPK14/EDNRB/BMPR1A/PPP3CA/CAT/FOXO4/ATM/PLA2R1/SOD1 31 GO:0072171 mesonephric tubule morphogenesis 9/1115 63/18722 0.0118793545575803 0.0803966938749438 LAMA5/LGR4/PBX1/MAGED1/DLG1/GLI3/PKD2/GPC3/CTNNB1 9 GO:1904589 regulation of protein import 9/1115 63/18722 0.0118793545575803 0.0803966938749438 CDH1/TPR/HSP90AB1/UBR5/FERMT1/GLI3/MAPK14/RAN/MAVS 9 GO:0034446 substrate adhesion-dependent cell spreading 13/1115 108/18722 0.0118815973995791 0.0803966938749438 LAMA5/LAMC1/LAMB1/KANK1/ITGAV/NRP1/FBLN1/ACTN4/FN1/P4HB/S100A10/EFNA5/RHOA 13 GO:0060021 roof of mouth development 11/1115 85/18722 0.0118961206520333 0.0803966938749438 ITGB8/TGFBR3/DLG1/TGFBR1/GLI3/SMAD2/FRAS1/ARID5B/BMPR1A/ITGB6/DHRS3 11 GO:0098773 skin epidermis development 11/1115 85/18722 0.0118961206520333 0.0803966938749438 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ/FZD6/ZDHHC21/FGFR2/FZD3/CTNNB1 11 GO:0035264 multicellular organism growth 15/1115 132/18722 0.0120239702394634 0.0808448895118459 LGMN/APP/ADRB1/NIPBL/ZFP36L1/ATRX/PLEC/TNKS2/ZFX/CELF1/RBBP6/ARID5B/PLAG1/GPAT4/SOD1 15 GO:0032411 positive regulation of transporter activity 14/1115 120/18722 0.0120307500476218 0.0808448895118459 AKAP9/TCAF1/CALM1/ANK3/SLC9A1/ACTN4/KIF5B/DMD/WNK1/TMSB4X/KMT2A/ALG10B/PKD2/VMP1 14 GO:0030968 endoplasmic reticulum unfolded protein response 10/1115 74/18722 0.0120490521103749 0.0808448895118459 ATF6/ERLEC1/CREB3L2/UFL1/HSPA5/AMFR/TMEM33/CCND1/PPP1R15B/WFS1 10 GO:0046323 glucose import 10/1115 74/18722 0.0120490521103749 0.0808448895118459 SLC2A1/PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/INSR/OCLN/GPC3 10 GO:0048332 mesoderm morphogenesis 10/1115 74/18722 0.0120490521103749 0.0808448895118459 ITGB1/ITGB4/WLS/GJA1/BMP7/BMPR2/SMAD2/SETD2/BMPR1A/FGFR2 10 GO:0021543 pallium development 18/1115 169/18722 0.012067475360136 0.0808448895118459 LRP1/ADGRG1/LAMB1/SLC2A1/CDK6/ATP2B4/RTN4/SLC38A2/NF1/TACC2/KIF5B/GLI3/CELF1/TSKU/TRA2B/UBA6/CTNNB1/RHOA 18 GO:0051271 negative regulation of cellular component movement 33/1115 367/18722 0.0121519280187127 0.0808448895118459 LRP1/DAG1/CDH1/ADGRG1/TCAF1/SEMA6D/KANK1/FBLN1/ATP2B4/MIF/DPP4/CD74/NF1/GJA1/TGFBR3/SERPINF1/DLG5/GNA12/GSTP1/JAG1/NR2F2/PTPRM/MIA3/WASL/NISCH/HMGB1/S1PR2/PTPRK/OSBPL8/BMPR1A/CCDC125/SRGAP1/RHOA 33 GO:0031116 positive regulation of microtubule polymerization 6/1115 33/18722 0.0122097568608785 0.0808448895118459 AKAP9/MET/CLIP1/RPS3/OCLN/HSPA1A 6 GO:0048048 embryonic eye morphogenesis 6/1115 33/18722 0.0122097568608785 0.0808448895118459 FBN1/FBN2/EFEMP1/BMP7/FZD5/PHACTR4 6 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 6/1115 33/18722 0.0122097568608785 0.0808448895118459 ZNF451/MED13/DHX36/HMGB1/ATF7IP/SUB1 6 GO:0071353 cellular response to interleukin-4 6/1115 33/18722 0.0122097568608785 0.0808448895118459 RPL3/RPLP0/HSP90AB1/HSPA5/PARP14/FASN 6 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 6/1115 33/18722 0.0122097568608785 0.0808448895118459 EGFR/HSP90AB1/ADAM17/CCND1/PKD2/CKS1B 6 GO:0007035 vacuolar acidification 5/1115 24/18722 0.0122198587443453 0.0808448895118459 GRN/TMEM106B/CLN5/CLN3/ATP6V0A1 5 GO:0021801 cerebral cortex radial glia-guided migration 5/1115 24/18722 0.0122198587443453 0.0808448895118459 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1 5 GO:0022030 telencephalon glial cell migration 5/1115 24/18722 0.0122198587443453 0.0808448895118459 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1 5 GO:0030859 polarized epithelial cell differentiation 5/1115 24/18722 0.0122198587443453 0.0808448895118459 DLG5/FAT1/AHI1/PTK7/RHOA 5 GO:2001026 regulation of endothelial cell chemotaxis 5/1115 24/18722 0.0122198587443453 0.0808448895118459 MET/LGMN/P2RX4/TMSB4X/HSPB1 5 GO:0007030 Golgi organization 17/1115 157/18722 0.0123962117726919 0.0819101171465374 AKAP9/GOLGB1/LMAN1/ARHGAP21/USO1/TRIP11/ARFGEF1/GCC2/TMED4/SURF4/YIPF4/TMED1/CAMSAP2/CSNK1A1/OBSL1/VMP1/RAB2A 17 GO:0070167 regulation of biomineral tissue development 12/1115 97/18722 0.0124692323231515 0.0822907680757797 FBN2/ATP2B1/ANO6/BMP7/ANKH/LTBP3/ROCK1/SLC4A2/BMPR2/BMPR1A/ACVR2B/ATRAID 12 GO:0030705 cytoskeleton-dependent intracellular transport 20/1115 195/18722 0.0125416194878592 0.0825847643221415 SYNE2/APP/DST/ARHGAP21/MYO1C/ACTN4/PCM1/CCDC186/RAB6A/DYNC1H1/KIF5B/LRPPRC/HOOK2/WASL/MYO7A/HSPB1/CLN3/TRAK2/MYO6/SOD1 20 GO:0008347 glial cell migration 8/1115 53/18722 0.0125563600142741 0.0825847643221415 LRP1/ADGRG1/LAMB1/RTN4/HEXB/P2RX4/GLI3/CTNNB1 8 GO:0007517 muscle organ development 30/1115 327/18722 0.0125601851713015 0.0825847643221415 LRP2/LAMA5/DAG1/UTRN/TGFBR3/ZFHX3/PLEC/DDX17/GPC1/TGFBR1/NR2F2/DMD/RBPJ/DSP/LY6E/MAPK14/ZNF609/CFLAR/PKP2/CAV1/ARID5B/MYL6/BMPR1A/PPP3CA/FGFR2/ISL1/FOXO4/CTNNB1/RHOA/YBX3 30 GO:0061351 neural precursor cell proliferation 16/1115 145/18722 0.0126586596441896 0.0827030877833128 LRP2/SPINT1/ADGRG1/SLC6A4/NF1/PLXNB2/PCM1/RYK/GLI3/FZD6/SLC16A2/FGFR2/FZD3/RERE/CTNNB1/RHOA 16 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 22/1115 221/18722 0.0127009295965735 0.0827030877833128 RPL23/RPL5/CTSC/HECTD1/HSP90AB1/USP25/GNA12/RNF217/UFL1/ZYG11B/SMARCC1/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/CSNK1A1/EIF3H/RHBDF1/CDC20/HSPA1A 22 GO:0032414 positive regulation of ion transmembrane transporter activity 13/1115 109/18722 0.012779007058542 0.0827030877833128 AKAP9/TCAF1/CALM1/ANK3/SLC9A1/ACTN4/KIF5B/DMD/WNK1/TMSB4X/ALG10B/PKD2/VMP1 13 GO:0005980 glycogen catabolic process 4/1115 16/18722 0.0127950459840825 0.0827030877833128 AGL/GAA/RB1CC1/HMGB1 4 GO:0009415 response to water 4/1115 16/18722 0.0127950459840825 0.0827030877833128 KRT8/ATP2B4/PLEC/PKD2 4 GO:0017014 protein nitrosylation 4/1115 16/18722 0.0127950459840825 0.0827030877833128 GAPDH/ATP2B4/DMD/OXR1 4 GO:0018119 peptidyl-cysteine S-nitrosylation 4/1115 16/18722 0.0127950459840825 0.0827030877833128 GAPDH/ATP2B4/DMD/OXR1 4 GO:0019377 glycolipid catabolic process 4/1115 16/18722 0.0127950459840825 0.0827030877833128 HEXB/HEXA/GM2A/FUCA1 4 GO:0021783 preganglionic parasympathetic fiber development 4/1115 16/18722 0.0127950459840825 0.0827030877833128 NRP2/NRP1/SEMA3F/NAV2 4 GO:0033631 cell-cell adhesion mediated by integrin 4/1115 16/18722 0.0127950459840825 0.0827030877833128 ITGB1/DPP4/PLPP3/WNK1 4 GO:0035751 regulation of lysosomal lumen pH 4/1115 16/18722 0.0127950459840825 0.0827030877833128 GRN/TMEM106B/CLN5/CLN3 4 GO:0072148 epithelial cell fate commitment 4/1115 16/18722 0.0127950459840825 0.0827030877833128 NRP1/NR2F2/RBPJ/ESRP1 4 GO:0097284 hepatocyte apoptotic process 4/1115 16/18722 0.0127950459840825 0.0827030877833128 KRT8/KRT18/DNMT3A/CFLAR 4 GO:2001224 positive regulation of neuron migration 4/1115 16/18722 0.0127950459840825 0.0827030877833128 SEMA6A/NIPBL/ZNF609/RAPGEF2 4 GO:0042177 negative regulation of protein catabolic process 14/1115 121/18722 0.0128838897564067 0.0831721669394615 EGFR/RPL23/RPL5/MYCBP2/FURIN/HSP90AB1/USP25/MDM4/ROCK1/SMARCC1/CTSA/ANXA2/EIF3H/ATRAID 14 GO:0006493 protein O-linked glycosylation 11/1115 86/18722 0.012929930428873 0.0831721669394615 GALNT11/GXYLT1/C1GALT1/TET2/B4GALT5/B3GNT2/B3GNT5/GCNT4/B3GNT3/TMTC3/TRAK2 11 GO:0015908 fatty acid transport 11/1115 86/18722 0.012929930428873 0.0831721669394615 ANXA1/SLC2A1/PLIN2/SLC27A2/P2RX4/CROT/SLC27A6/CPT2/ABCD3/ACSL3/PLA2R1 11 GO:0035023 regulation of Rho protein signal transduction 11/1115 86/18722 0.012929930428873 0.0831721669394615 ADGRG1/MET/ITGB1/KANK1/NRP1/ABCA1/NET1/AKAP13/F11R/CCDC125/CDC42SE1 11 GO:0043410 positive regulation of MAPK cascade 41/1115 480/18722 0.0129737059656538 0.0833533287011136 EGFR/LRP1/IQGAP1/FLT1/NRP1/IGF1R/APP/MIF/CD74/PPIA/GCNT2/MAGED1/RPS3/ARL6IP5/RB1CC1/TAOK1/AKAP13/ATP6AP1/ROCK1/TGFBR1/RYK/FZD5/TPBG/DVL3/TRPV4/TAOK3/C1QTNF1/EMC10/HMGB1/SEMA7A/PDGFD/CFLAR/GAREM1/INSR/TLR3/FGFR2/ERBB2/RAPGEF2/CTNNB1/LTBR/SOD1 41 GO:0030837 negative regulation of actin filament polymerization 9/1115 64/18722 0.0131146036351035 0.0840562650754113 KANK1/PFN1/SCIN/SPTBN1/ADD3/ARFGEF1/SPTAN1/KANK4/TMSB4X 9 GO:0050771 negative regulation of axonogenesis 9/1115 64/18722 0.0131146036351035 0.0840562650754113 SEMA6D/NRP1/SEMA6A/RTN4/SEMA3F/RYK/SEMA4B/SEMA7A/TRAK2 9 GO:0036465 synaptic vesicle recycling 10/1115 75/18722 0.0131836659562639 0.0843975929742124 CANX/ACTG1/CALM1/KIAA1109/STON1/SYT7/ROCK1/DNAJC6/ITSN2/ACTB 10 GO:0033002 muscle cell proliferation 24/1115 248/18722 0.0132206846003192 0.0845332156659929 EGFR/GJA1/TGFBR3/PRKDC/SF1/GNA12/GSTP1/ADAMTS1/TGFBR1/TCF7L2/SKP2/JARID2/RBPJ/BMPR2/FOXP1/S1PR2/MAPK14/PDGFD/CFLAR/BMPR1A/FGFR2/CTNNB1/RHOA/HPGD 24 GO:0001933 negative regulation of protein phosphorylation 31/1115 342/18722 0.0132691603883534 0.0847416833892569 LRP1/LRP5/NPM1/FBLN1/PLPP3/NF1/PPIA/CALM1/PRKDC/PLEC/BMP7/GNAQ/GSTP1/NR2F2/SMPD1/GPD1L/PARP14/PKIB/DMD/C9orf72/LATS2/DNAJC3/HSPB1/IPO7/CAV1/PPP1R15B/SUZ12/IBTK/DNAJA1/OCLN/CDKN1C 31 GO:0003333 amino acid transmembrane transport 12/1115 98/18722 0.0134640791599114 0.0857812871536599 ITGB1/SLC38A2/SLC43A2/SLC1A5/SLC38A10/ARL6IP5/SLC38A9/SLC7A6/SLC38A1/SLC7A2/SLC1A3/SLC16A2 12 GO:1904029 regulation of cyclin-dependent protein kinase activity 12/1115 98/18722 0.0134640791599114 0.0857812871536599 EGFR/HSP90AB1/NR2F2/LATS2/ADAM17/IPO7/CCND1/ACTB/PKD2/CKS1B/CDKN1C/CDKN3 12 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 15/1115 134/18722 0.0136799914614202 0.0870530088349491 HECTD1/HSP90AB1/GNA12/RNF217/UFL1/ZYG11B/SMARCC1/PIAS1/RNF19A/CAV1/DDA1/CSNK1A1/EIF3H/CDC20/HSPA1A 15 GO:0007623 circadian rhythm 21/1115 210/18722 0.0139847878890607 0.0888866458805894 EGFR/LGR4/MYCBP2/SLC6A4/ADRB1/PRKDC/ZFHX3/MAGED1/GNAQ/NCOR1/DDB1/USP9X/KDM5A/KLF10/SIAH2/NAGLU/CLDN4/NCOA2/KMT2A/OPN3/HNRNPD 21 GO:1900182 positive regulation of protein localization to nucleus 11/1115 87/18722 0.0140304664306761 0.0890709396829721 CDH1/NPM1/TPR/HSP90AB1/UBR5/TFRC/GLI3/MAPK14/RAN/MAVS/CCT3 11 GO:0032212 positive regulation of telomere maintenance via telomerase 6/1115 34/18722 0.0140980410484051 0.0891040730881411 HNRNPA1/TNKS2/PKIB/ATM/CTNNB1/CCT3 6 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 6/1115 34/18722 0.0140980410484051 0.0891040730881411 NPM1/MIF/CD74/RPL26/ATM/PLA2R1 6 GO:0051085 chaperone cofactor-dependent protein refolding 6/1115 34/18722 0.0140980410484051 0.0891040730881411 CD74/PTGES3/DNAJB14/HSPA5/HSPA1A/HSPE1 6 GO:0007548 sex differentiation 26/1115 276/18722 0.014102442734497 0.0891040730881411 LRP2/ADGRG1/LGR4/PBX1/NIPBL/ATRX/SF1/PRDX4/ADAMTS1/TGFBR1/HSPA5/KDM5A/NR2F2/RHOBTB3/ZFX/DHCR24/RAB13/CCND1/ARID5B/BMPR1A/TLR3/IDH1/EIF2S2/CTNNB1/SOD1/YBX3 26 GO:0007162 negative regulation of cell adhesion 28/1115 303/18722 0.0141860329192961 0.0895262763074726 LRP1/CDH1/ANXA1/KANK1/SEMA6A/FBLN1/PLXNB1/CD74/ERBB3/GCNT2/PLXNB2/ADAM10/RASA1/PLXNA1/DLG5/DLG1/ACTN4/JAG1/WNK1/TRPV4/GLI3/MIA3/C1QTNF1/HMGB1/EFNA5/RC3H1/ERBB2/RHOA 28 GO:1901136 carbohydrate derivative catabolic process 18/1115 172/18722 0.0142746258155772 0.0898651162474923 GNS/EDEM3/GLB1/HEXB/STT3B/MANBA/HEXA/GM2A/GPC1/GUSB/GPD1L/FUCA1/NAGLU/PDE10A/PDE7A/TDG/MGAT1/MAN1B1 18 GO:0015909 long-chain fatty acid transport 9/1115 65/18722 0.0144426340048377 0.0898651162474923 ANXA1/SLC2A1/PLIN2/SLC27A2/SLC27A6/CPT2/ABCD3/ACSL3/PLA2R1 9 GO:0048645 animal organ formation 9/1115 65/18722 0.0144426340048377 0.0898651162474923 LRP2/BMP7/FOLR1/RBPJ/GLI3/BMPR1A/FGFR2/ISL1/CTNNB1 9 GO:0070936 protein K48-linked ubiquitination 9/1115 65/18722 0.0144426340048377 0.0898651162474923 PPIA/UBR5/TTC3/TRIM44/AMFR/SKP2/UBE2H/SKP1/UBE2C 9 GO:1902475 L-alpha-amino acid transmembrane transport 9/1115 65/18722 0.0144426340048377 0.0898651162474923 ITGB1/SLC43A2/SLC1A5/ARL6IP5/SLC38A9/SLC7A6/SLC38A1/SLC7A2/SLC1A3 9 GO:0021762 substantia nigra development 7/1115 44/18722 0.0144553378500687 0.0898651162474923 DYNLL1/CALM1/YWHAE/HSPA5/GNB4/ACTB/RHOA 7 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 7/1115 44/18722 0.0144553378500687 0.0898651162474923 DLG5/DLG1/FAT1/PRKCI/PTK7/ARF4/RHOA 7 GO:0089718 amino acid import across plasma membrane 7/1115 44/18722 0.0144553378500687 0.0898651162474923 ITGB1/SLC43A2/SLC1A5/ARL6IP5/SLC7A2/SLC1A3/SLC16A2 7 GO:0051896 regulation of protein kinase B signaling 19/1115 185/18722 0.0145046722304092 0.0898651162474923 EGFR/LRP2/DAG1/MET/ITGB1/IGF1R/RTN4/GCNT2/P2RX4/HSP90AB1/ARFGEF1/DLG1/TGFBR1/TCF7L2/RICTOR/TPBG/C1QTNF1/OSBPL8/INSR 19 GO:0030838 positive regulation of actin filament polymerization 12/1115 99/18722 0.0145183421797161 0.0898651162474923 PFN1/IQGAP2/SCIN/MYO1C/DLG1/RICTOR/NCKAP1/WASL/ARPC3/ABI2/RHOA/WASF2 12 GO:0060996 dendritic spine development 12/1115 99/18722 0.0145183421797161 0.0898651162474923 CFL1/CDKL5/ADAM10/DLG5/PPP1R9A/WASL/DHX36/ASAP1/ABI2/UBA6/C21orf91/ARF4 12 GO:0110149 regulation of biomineralization 12/1115 99/18722 0.0145183421797161 0.0898651162474923 FBN2/ATP2B1/ANO6/BMP7/ANKH/LTBP3/ROCK1/SLC4A2/BMPR2/BMPR1A/ACVR2B/ATRAID 12 GO:0006658 phosphatidylserine metabolic process 5/1115 25/18722 0.0145426972163014 0.0898651162474923 SERINC1/SERINC3/OSBPL8/LPCAT3/SERINC2 5 GO:0010560 positive regulation of glycoprotein biosynthetic process 5/1115 25/18722 0.0145426972163014 0.0898651162474923 ARFGEF1/TCF7L2/NCSTN/ALG10B/CTNNB1 5 GO:0032469 endoplasmic reticulum calcium ion homeostasis 5/1115 25/18722 0.0145426972163014 0.0898651162474923 APP/ATP2A2/GRINA/CCDC47/WFS1 5 GO:0032878 regulation of establishment or maintenance of cell polarity 5/1115 25/18722 0.0145426972163014 0.0898651162474923 KANK1/DOCK8/ARFGEF1/ROCK1/RICTOR 5 GO:0033119 negative regulation of RNA splicing 5/1115 25/18722 0.0145426972163014 0.0898651162474923 NPM1/RPS13/PTBP3/SAP18/SRSF9 5 GO:0062009 secondary palate development 5/1115 25/18722 0.0145426972163014 0.0898651162474923 ITGB8/TGFBR3/DLG1/SMAD2/ITGB6 5 GO:0002687 positive regulation of leukocyte migration 15/1115 135/18722 0.0145717285062453 0.0899404144449059 LGMN/APP/CD74/ANO6/DOCK8/P2RX4/ADAM10/CD47/ADAM17/WNK1/TRPV4/MIA3/HMGB1/PDGFD/RHOA 15 GO:0019318 hexose metabolic process 23/1115 237/18722 0.0145958271765437 0.0899851285168208 GAPDH/LRP5/GAA/ALDOA/GLB1/RANBP2/B4GALT1/MAN2A1/ENO1/DDB1/TPI1/SLC35B4/FUCA1/EPM2AIP1/SORBS1/NISCH/C1QTNF1/HMGB1/SOGA1/NCOA2/MAPK14/G6PC3/INSR 23 GO:2000146 negative regulation of cell motility 32/1115 359/18722 0.0150191141883237 0.0924879476948793 LRP1/DAG1/CDH1/ADGRG1/TCAF1/SEMA6D/KANK1/FBLN1/ATP2B4/MIF/DPP4/CD74/NF1/GJA1/SERPINF1/DLG5/GNA12/GSTP1/JAG1/NR2F2/PTPRM/MIA3/WASL/NISCH/HMGB1/S1PR2/PTPRK/OSBPL8/BMPR1A/CCDC125/SRGAP1/RHOA 32 GO:0003015 heart process 24/1115 251/18722 0.0151292721669105 0.093008419177981 AKAP9/ATP2B1/DSC2/ADRB1/ATP2B4/GAA/GJA1/CALM1/DSG2/P2RX4/YWHAE/SLC9A1/DLG1/ATP2A2/AKAP13/GJA5/GPD1L/DMD/ATP1A1/DSP/PKP2/CAV1/ISL1/SOD1 24 GO:0010038 response to metal ion 33/1115 373/18722 0.0151384746704749 0.093008419177981 EGFR/CDH1/IQGAP1/LGMN/APP/CALM1/SERPINF1/ANK3/P2RX4/DNMT3A/SLC11A2/SYT7/HSPA5/AOC1/NPC1/AHCYL1/ADCY7/SEC31A/SMPD1/NCSTN/WNK1/CUTA/CAV1/CCND1/ALG2/PKD2/PPP3CA/CAT/GGH/ATP7B/HNRNPD/FUS/SOD1 33 GO:0070507 regulation of microtubule cytoskeleton organization 16/1115 148/18722 0.0151726921385601 0.0931114980778994 AKAP9/MET/CLIP1/RPS3/TPR/CLTC/TAOK1/ROCK1/DYNC1H1/TRPV4/SENP6/CAMSAP2/EFNA5/OCLN/HSPA1A/RHOA 16 GO:0022898 regulation of transmembrane transporter activity 26/1115 278/18722 0.0153452062526922 0.0940620622079488 AHNAK/AKAP9/TCAF1/ITGB1/UTRN/APP/GJA1/CALM1/ANK3/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KIF5B/AHCYL1/GPD1L/DMD/WNK1/TMSB4X/CAV1/STOM/ALG10B/ACTB/PKD2/VMP1 26 GO:0043401 steroid hormone mediated signaling pathway 15/1115 136/18722 0.0155077616307413 0.0949494717276693 DDX17/BMP7/PTGES3/NR3C1/ESRRG/UBR5/NCOR1/UFL1/ARID1A/SKP2/FOXP1/PAQR7/ISL1/DNAJA1/RHOA 15 GO:0031016 pancreas development 10/1115 77/18722 0.0156909194019931 0.0959608461480424 MET/ANXA1/CDK6/WLS/TCF7L2/MEIS2/SMAD2/ISL1/CTNNB1/WFS1 10 GO:1901222 regulation of NIK/NF-kappaB signaling 13/1115 112/18722 0.0157863416417507 0.0964339565506947 EGFR/PRDX1/APP/NFAT5/RPS3/BMP7/ACTN4/TRIM44/TMSB4X/HMGB1/TLR3/RC3H1/RHOA 13 GO:0014015 positive regulation of gliogenesis 9/1115 66/18722 0.0158672786904299 0.0967083740553329 EGFR/LRP2/SPINT1/DAG1/IL6ST/DICER1/UFL1/PRKCI/PLAG1 9 GO:0009251 glucan catabolic process 4/1115 17/18722 0.01595805910147 0.0967083740553329 AGL/GAA/RB1CC1/HMGB1 4 GO:0036035 osteoclast development 4/1115 17/18722 0.01595805910147 0.0967083740553329 FBN1/ATP6AP1/FOXP1/ANXA2 4 GO:0042339 keratan sulfate metabolic process 4/1115 17/18722 0.01595805910147 0.0967083740553329 GNS/GLB1/B3GNT2/B3GNT3 4 GO:0042953 lipoprotein transport 4/1115 17/18722 0.01595805910147 0.0967083740553329 LRP1/MIA3/ZDHHC17/VMP1 4 GO:0061450 trophoblast cell migration 4/1115 17/18722 0.01595805910147 0.0967083740553329 ITGB4/GJA1/AGO2/SMURF2 4 GO:0070875 positive regulation of glycogen metabolic process 4/1115 17/18722 0.01595805910147 0.0967083740553329 EPM2AIP1/SORBS1/HMGB1/INSR 4 GO:0010639 negative regulation of organelle organization 31/1115 347/18722 0.0160159295717097 0.0969490339947369 MET/HNRNPA1/KANK1/PFN1/NPM1/SCIN/ATRX/SPTBN1/BMP7/TPR/ADD3/ARFGEF1/TAOK1/SPTAN1/ARHGAP28/TFRC/TNKS2/PPP1R9A/KANK4/PPFIA1/F11R/TMSB4X/XRN1/DCP2/CAMSAP2/SLC35F6/ZNF207/HNRNPC/ATM/HSPA1A/WASF2 31 GO:0009411 response to UV 16/1115 149/18722 0.0160914924342138 0.0972254193442922 EGFR/MME/NPM1/USP47/RPL26/DDB1/SMPD1/TP53I13/DHX36/SCARA3/PTPRK/OPN3/CCND1/UBE4B/CAT/CREBBP 16 GO:0061136 regulation of proteasomal protein catabolic process 19/1115 187/18722 0.0160980091216247 0.0972254193442922 HECTD1/HSP90AB1/USP25/GNA12/RNF217/UFL1/ZYG11B/SMARCC1/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/CSNK1A1/EIF3H/RHBDF1/CDC20/HSPA1A 19 GO:0001893 maternal placenta development 6/1115 35/18722 0.0161805151843175 0.0973932024454012 ASH1L/GJA1/CTSB/NR2F2/BMPR2/PRDX3 6 GO:0032205 negative regulation of telomere maintenance 6/1115 35/18722 0.0161805151843175 0.0973932024454012 HNRNPA1/TNKS2/XRN1/DCP2/HNRNPC/ATM 6 GO:2000403 positive regulation of lymphocyte migration 6/1115 35/18722 0.0161805151843175 0.0973932024454012 APP/DOCK8/ADAM10/ADAM17/WNK1/RHOA 6 GO:0035307 positive regulation of protein dephosphorylation 7/1115 45/18722 0.0162637553631577 0.0976740043688403 SLC39A10/PPIA/CALM1/HSP90AB1/SMPD1/PPP1R12A/PPP1R15B 7 GO:0044088 regulation of vacuole organization 7/1115 45/18722 0.0162637553631577 0.0976740043688403 GRN/SCARB2/TMEM106B/C9orf72/RAB3GAP1/RAB3GAP2/ANXA2 7 GO:0060537 muscle tissue development 35/1115 403/18722 0.0163734769718362 0.0982224646658805 LRP2/ITGB1/NF1/GJA1/TGFBR3/PLEC/DSG2/DDX17/BMP7/SLC9A1/DLG1/AKAP13/GPC1/TGFBR1/GJA5/NR2F2/DMD/JARID2/RBPJ/DSP/LY6E/MAPK14/CFLAR/PKP2/CAV1/MYL6/BMPR1A/OBSL1/PKD2/PPP3CA/FGFR2/ISL1/CTNNB1/RHOA/YBX3 35 GO:0010977 negative regulation of neuron projection development 15/1115 137/18722 0.0164894526925979 0.0988071693892035 LRP1/SEMA6D/KANK1/NRP1/SEMA6A/RTN4/SEMA3F/RYK/SEMA4B/THOC2/TRPV4/SEMA7A/TSKU/TRAK2/RHOA 15 GO:0051053 negative regulation of DNA metabolic process 14/1115 125/18722 0.0167731793159038 0.100394623730505 HNRNPA1/GJA1/RPS3/UBR5/RIF1/TNKS2/TRIP12/BMPR2/XRN1/DCP2/KMT2A/HNRNPC/ATM/SUB1 14 GO:0051054 positive regulation of DNA metabolic process 20/1115 201/18722 0.0170019411910152 0.101649903716495 EGFR/HNRNPA1/ATRX/PRKDC/RPS3/PTGES3/HSP90AB1/RIF1/USP9X/TFRC/TNKS2/PKIB/DHX36/HNRNPA2B1/HMGB1/ATM/CTNNB1/HNRNPD/CCT3/FUS 20 GO:0030500 regulation of bone mineralization 10/1115 78/18722 0.0170696900037641 0.101826899363236 FBN2/ATP2B1/ANO6/BMP7/ANKH/LTBP3/BMPR2/BMPR1A/ACVR2B/ATRAID 10 GO:0034637 cellular carbohydrate biosynthetic process 10/1115 78/18722 0.0170696900037641 0.101826899363236 AGL/PTGES3/B4GALT1/B4GALT5/B3GNT2/B3GNT3/EPM2AIP1/SORBS1/INSR/ISYNA1 10 GO:0001573 ganglioside metabolic process 5/1115 26/18722 0.0171438122542559 0.102041040831073 ITGB8/HEXB/HEXA/GM2A/B4GALT5 5 GO:0006027 glycosaminoglycan catabolic process 5/1115 26/18722 0.0171438122542559 0.102041040831073 GNS/GLB1/GUSB/FUCA1/NAGLU 5 GO:0042733 embryonic digit morphogenesis 8/1115 56/18722 0.0172196588440985 0.102378350299156 LRP5/CHST11/GLI3/FZD6/BMPR1A/FREM2/CREBBP/CTNNB1 8 GO:0006470 protein dephosphorylation 26/1115 281/18722 0.0173713959120975 0.10316560931556 PTPRF/HSP90B1/SLC39A10/BOD1L1/PPIA/CALM1/HSP90AB1/YWHAE/DLG1/PTPN14/PTPRA/ROCK1/SMPD1/NCEH1/PDP2/PPP6R2/PTP4A1/PPP1R12A/PTPRM/PPP6R3/PPP4R1/DNAJC6/PTPRK/PPP1R15B/PPP3CA/CDKN3 26 GO:0070527 platelet aggregation 9/1115 67/18722 0.0173923181889747 0.103175096456595 IL6ST/ACTG1/PPIA/MYL12A/FN1/F11R/HSPB1/C1QTNF1/ACTB 9 GO:0050657 nucleic acid transport 17/1115 163/18722 0.0174460340315012 0.103264274605526 HNRNPA1/NPM1/ZFP36L1/YBX1/TPR/MYO1C/SRSF3/RANBP2/SMG1/THOC2/LRPPRC/SETD2/HNRNPA2B1/RAN/RANBP17/EIF5A/HNRNPA3 17 GO:0050658 RNA transport 17/1115 163/18722 0.0174460340315012 0.103264274605526 HNRNPA1/NPM1/ZFP36L1/YBX1/TPR/MYO1C/SRSF3/RANBP2/SMG1/THOC2/LRPPRC/SETD2/HNRNPA2B1/RAN/RANBP17/EIF5A/HNRNPA3 17 GO:0060047 heart contraction 23/1115 241/18722 0.0174838143254311 0.103373294223119 AKAP9/ATP2B1/DSC2/ADRB1/ATP2B4/GAA/GJA1/CALM1/DSG2/P2RX4/YWHAE/SLC9A1/DLG1/ATP2A2/GJA5/GPD1L/DMD/ATP1A1/DSP/PKP2/CAV1/ISL1/SOD1 23 GO:0009913 epidermal cell differentiation 20/1115 202/18722 0.0178527914595915 0.105438112392432 ANXA1/ASAH1/ZFP36L1/NCOA3/EXPH5/PLEC/SGPP1/MCOLN3/ST14/JAG1/ROCK1/PALLD/RBPJ/MYO7A/DSP/ESRP1/OPN3/MYO6/CTNNB1/SOD1 20 GO:0006672 ceramide metabolic process 12/1115 102/18722 0.0180587901312704 0.105556053756082 ITGB8/ASAH1/PLPP3/HEXB/ORMDL1/HEXA/GM2A/B4GALT5/SMPD1/DEGS1/SPTLC3/ELOVL1 12 GO:0021987 cerebral cortex development 13/1115 114/18722 0.0180718493481381 0.105556053756082 LRP1/ADGRG1/LAMB1/SLC2A1/RTN4/SLC38A2/NF1/TACC2/GLI3/CELF1/TRA2B/CTNNB1/RHOA 13 GO:0048701 embryonic cranial skeleton morphogenesis 7/1115 46/18722 0.0182266027538683 0.105556053756082 NIPBL/TGFBR1/CHST11/GLI3/SMAD2/SETD2/FGFR2 7 GO:0061028 establishment of endothelial barrier 7/1115 46/18722 0.0182266027538683 0.105556053756082 ROCK1/F11R/S1PR2/S1PR3/ZDHHC21/RAPGEF2/FASN 7 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 17/1115 164/18722 0.0184231787609236 0.105556053756082 RPL23/RPL5/HECTD1/HSP90AB1/GNA12/RNF217/UFL1/ZYG11B/SMARCC1/PIAS1/RNF19A/CAV1/DDA1/CSNK1A1/EIF3H/CDC20/HSPA1A 17 GO:0002934 desmosome organization 3/1115 10/18722 0.0184340137189596 0.105556053756082 DSG2/DSP/PKP2 3 GO:0003056 regulation of vascular associated smooth muscle contraction 3/1115 10/18722 0.0184340137189596 0.105556053756082 ATP2B1/ZDHHC21/RHOA 3 GO:0009950 dorsal/ventral axis specification 3/1115 10/18722 0.0184340137189596 0.105556053756082 SMAD2/BMPR1A/CTNNB1 3 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 3/1115 10/18722 0.0184340137189596 0.105556053756082 NPM1/DNAJC3/PPP1R15B 3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 3/1115 10/18722 0.0184340137189596 0.105556053756082 PRDX4/P4HB/P4HTM 3 GO:0031340 positive regulation of vesicle fusion 3/1115 10/18722 0.0184340137189596 0.105556053756082 ANXA1/KIF5B/ANXA2 3 GO:0032070 regulation of deoxyribonuclease activity 3/1115 10/18722 0.0184340137189596 0.105556053756082 NPM1/RPS3/HMGB1 3 GO:0042996 regulation of Golgi to plasma membrane protein transport 3/1115 10/18722 0.0184340137189596 0.105556053756082 LYPLA1/CLN3/ACSL3 3 GO:0048755 branching morphogenesis of a nerve 3/1115 10/18722 0.0184340137189596 0.105556053756082 RTN4/FGFR2/RERE 3 GO:0060736 prostate gland growth 3/1115 10/18722 0.0184340137189596 0.105556053756082 PSAP/FGFR2/PLAG1 3 GO:0061299 retina vasculature morphogenesis in camera-type eye 3/1115 10/18722 0.0184340137189596 0.105556053756082 LRP5/NRP1/COL4A1 3 GO:0072070 loop of Henle development 3/1115 10/18722 0.0184340137189596 0.105556053756082 JAG1/PKD2/IRX2 3 GO:0072124 regulation of glomerular mesangial cell proliferation 3/1115 10/18722 0.0184340137189596 0.105556053756082 BMP7/PDGFD/CFLAR 3 GO:0098885 modification of postsynaptic actin cytoskeleton 3/1115 10/18722 0.0184340137189596 0.105556053756082 PFN1/MYH10/RHOA 3 GO:1900246 positive regulation of RIG-I signaling pathway 3/1115 10/18722 0.0184340137189596 0.105556053756082 PUM2/PUM1/ANKRD17 3 GO:1904350 regulation of protein catabolic process in the vacuole 3/1115 10/18722 0.0184340137189596 0.105556053756082 LRP2/LRP1/RNF128 3 GO:1904668 positive regulation of ubiquitin protein ligase activity 3/1115 10/18722 0.0184340137189596 0.105556053756082 SKP1/UBE2C/CDC20 3 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 3/1115 10/18722 0.0184340137189596 0.105556053756082 ATP2B4/DMD/OXR1 3 GO:2000674 regulation of type B pancreatic cell apoptotic process 3/1115 10/18722 0.0184340137189596 0.105556053756082 TCF7L2/CAST/WFS1 3 GO:0003203 endocardial cushion morphogenesis 6/1115 36/18722 0.0184658839123769 0.105556053756082 BMP7/MDM4/TGFBR1/RBPJ/BMPR1A/ISL1 6 GO:0010092 specification of animal organ identity 6/1115 36/18722 0.0184658839123769 0.105556053756082 LRP2/RBPJ/GLI3/FGFR2/ISL1/CTNNB1 6 GO:0046466 membrane lipid catabolic process 6/1115 36/18722 0.0184658839123769 0.105556053756082 ASAH1/HEXB/HEXA/GM2A/SMPD1/FUCA1 6 GO:0070670 response to interleukin-4 6/1115 36/18722 0.0184658839123769 0.105556053756082 RPL3/RPLP0/HSP90AB1/HSPA5/PARP14/FASN 6 GO:0071402 cellular response to lipoprotein particle stimulus 6/1115 36/18722 0.0184658839123769 0.105556053756082 ITGB1/ABCA1/NPC1/ADAM17/MIA3/SREBF2 6 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 6/1115 36/18722 0.0184658839123769 0.105556053756082 TPT1/MIF/CD74/RPS3/USP47/RPL26 6 GO:0006446 regulation of translational initiation 10/1115 79/18722 0.0185359239179176 0.105843099248944 RPL13A/NPM1/EIF1/TPR/DNAJC3/HSPB1/AGO2/PPP1R15B/PAIP2/EIF3H 10 GO:0032409 regulation of transporter activity 28/1115 310/18722 0.0186860709837231 0.106498025412843 AHNAK/AKAP9/TCAF1/ITGB1/UTRN/APP/SLC5A3/GJA1/CALM1/ANK3/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KIF5B/AHCYL1/GPD1L/DMD/WNK1/TMSB4X/KMT2A/CAV1/STOM/ALG10B/ACTB/PKD2/VMP1 28 GO:0051346 negative regulation of hydrolase activity 33/1115 379/18722 0.0186905131694764 0.106498025412843 GAPDH/SPINT1/CRIM1/LRP1/ITIH5/ANXA1/APLP2/APP/BOD1L1/TFPI/SERPINF1/FURIN/USP47/BIRC6/ARFGEF1/ROCK1/IFI6/KDM5A/AMOT/SIAH2/WNK1/F11R/DHCR24/GCHFR/CAST/XIAP/ANXA2/SERPINB9/GPC3/BIRC5/PLA2R1/PRDX3/SERPINB1 33 GO:0002011 morphogenesis of an epithelial sheet 8/1115 57/18722 0.0190190792187641 0.108152947048245 DAG1/BMP7/JAG1/FERMT1/ADAM17/DDR1/PHACTR4/RHOA 8 GO:0010812 negative regulation of cell-substrate adhesion 9/1115 68/18722 0.019021467930006 0.108152947048245 LRP1/KANK1/FBLN1/GCNT2/RASA1/ACTN4/JAG1/EFNA5/RHOA 9 GO:0030509 BMP signaling pathway 16/1115 152/18722 0.0191070910960557 0.108524212087065 FBN1/LRP2/CRIM1/FSTL1/TGFBR3/BMP7/USP9X/TRIM33/RBPJ/BMPR2/SMAD2/XIAP/BMPR1A/SMURF2/GPC3/ACVR2B 16 GO:0030004 cellular monovalent inorganic cation homeostasis 12/1115 103/18722 0.019371830736913 0.109910950376598 GRN/SLC9A1/ATP6AP1/TMEM106B/SLC4A2/SLC1A3/CLN5/TTPA/CLCN3/ATP1A1/CLN3/ATP6V0A1 12 GO:0071772 response to BMP 17/1115 165/18722 0.0194418970320623 0.11007453685491 FBN1/LRP2/SPINT1/CRIM1/FSTL1/TGFBR3/BMP7/USP9X/TRIM33/RBPJ/BMPR2/SMAD2/XIAP/BMPR1A/SMURF2/GPC3/ACVR2B 17 GO:0071773 cellular response to BMP stimulus 17/1115 165/18722 0.0194418970320623 0.11007453685491 FBN1/LRP2/SPINT1/CRIM1/FSTL1/TGFBR3/BMP7/USP9X/TRIM33/RBPJ/BMPR2/SMAD2/XIAP/BMPR1A/SMURF2/GPC3/ACVR2B 17 GO:0006595 polyamine metabolic process 4/1115 18/18722 0.0195707329372831 0.11010341744168 OAZ1/SMS/AOC1/SAT1 4 GO:0044247 cellular polysaccharide catabolic process 4/1115 18/18722 0.0195707329372831 0.11010341744168 AGL/GAA/RB1CC1/HMGB1 4 GO:0044872 lipoprotein localization 4/1115 18/18722 0.0195707329372831 0.11010341744168 LRP1/MIA3/ZDHHC17/VMP1 4 GO:0048486 parasympathetic nervous system development 4/1115 18/18722 0.0195707329372831 0.11010341744168 NRP2/NRP1/SEMA3F/NAV2 4 GO:0071360 cellular response to exogenous dsRNA 4/1115 18/18722 0.0195707329372831 0.11010341744168 COLEC12/CAV1/TLR3/MAVS 4 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 4/1115 18/18722 0.0195707329372831 0.11010341744168 RBPJ/BMPR2/ISL1/CTNNB1 4 GO:0032786 positive regulation of DNA-templated transcription, elongation 5/1115 27/18722 0.0200353482062683 0.112244201545925 BRD4/TCERG1/CDK12/CDK13/CTNNB1 5 GO:0061437 renal system vasculature development 5/1115 27/18722 0.0200353482062683 0.112244201545925 NRP1/BMP7/PDGFD/CFLAR/PKD2 5 GO:0061440 kidney vasculature development 5/1115 27/18722 0.0200353482062683 0.112244201545925 NRP1/BMP7/PDGFD/CFLAR/PKD2 5 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 5/1115 27/18722 0.0200353482062683 0.112244201545925 HNRNPA1/TNKS2/XRN1/DCP2/HNRNPC 5 GO:0001570 vasculogenesis 10/1115 80/18722 0.0200925939974783 0.112446917560311 ITGAV/ITGB8/ZFP36L1/TGFBR3/RASA1/AMOT/SETD2/CAV1/RAPGEF2/CTNNB1 10 GO:0045332 phospholipid translocation 7/1115 47/18722 0.0203499588474646 0.113648985655454 ATP10D/ABCA1/ANO6/TMEM30A/KCNN4/TMEM30B/ATP11B 7 GO:0045601 regulation of endothelial cell differentiation 7/1115 47/18722 0.0203499588474646 0.113648985655454 JAG1/ROCK1/F11R/S1PR2/S1PR3/ZDHHC21/CTNNB1 7 GO:0003012 muscle system process 38/1115 452/18722 0.0204121557138948 0.113877219808238 AKAP9/DAG1/ATP2B1/IL6ST/UTRN/DSC2/ATP2B4/GAA/ALDOA/ASPH/GJA1/CALM1/DSG2/P2RX4/ENO1/SLC9A1/DLG1/ATP2A2/AKAP13/ROCK1/GJA5/GPD1L/DMD/JARID2/ATP1A1/TRPV4/DSP/CFLAR/PKP2/CAV1/ZDHHC21/EDNRB/MYOF/MYL6/PPP3CA/PPP1R12B/RHOA/SOD1 38 GO:0030307 positive regulation of cell growth 17/1115 166/18722 0.0205032586263986 0.114146921591597 EGFR/LRP1/GOLGA4/NRP1/MACF1/CDKL5/ADAM10/USP47/SLC9A1/FN1/TGFBR1/ADAM17/BMPR2/SEMA7A/ITSN2/ERBB2/RHOA 17 GO:1902904 negative regulation of supramolecular fiber organization 17/1115 166/18722 0.0205032586263986 0.114146921591597 MET/KANK1/PFN1/SCIN/SPTBN1/ADD3/ARFGEF1/TAOK1/SPTAN1/ARHGAP28/PPP1R9A/KANK4/PPFIA1/F11R/TMSB4X/CAMSAP2/WASF2 17 GO:0008286 insulin receptor signaling pathway 13/1115 116/18722 0.0205985825290113 0.114458011163661 KANK1/IGF1R/PHIP/PTPRA/GAB1/SMARCC1/SORBS1/SOGA1/OSBPL8/APPL1/SLC2A8/INSR/FOXO4 13 GO:0044772 mitotic cell cycle phase transition 36/1115 424/18722 0.0206020132474768 0.114458011163661 EGFR/ITGB1/ANXA1/CDK6/PBX1/RPS6/APP/ZFP36L1/CALM1/BRD4/PRKDC/TPR/USP47/BCAT1/RPL26/TAOK1/RPL24/DLG1/DDB1/ADAMTS1/SKP2/LATS2/ADAM17/PIAS1/TAOK3/JADE1/CCND1/ZNF207/APPL1/PKD2/PPP3CA/ANKRD17/FOXO4/ATM/UBE2C/CDKN3 36 GO:0007626 locomotory behavior 18/1115 179/18722 0.0206541511159444 0.114628391692336 APP/GAA/DPP4/ZFHX3/HEXB/MCOLN3/NCOR1/ANKH/VPS13A/NPC1/CLCN3/NAGLU/PUM1/NCOA2/OXR1/UBA6/NAV2/SOD1 18 GO:0034605 cellular response to heat 9/1115 69/18722 0.0207583659470374 0.115087139970127 TPR/HSP90AB1/YWHAE/ATP2A2/TRPV4/DHX36/CREBBP/ATM/HSPA1A 9 GO:0045787 positive regulation of cell cycle 28/1115 313/18722 0.0209308100596375 0.115498432681209 EGFR/ANXA1/LRP5/PBX1/NPM1/LGMN/SLC6A4/APP/ATRX/BRD4/TPR/PKN2/PHIP/ADAMTS1/DYNC1H1/MEIS2/CCPG1/ADAM17/RANBP1/CCND1/INSR/PKD2/FGFR2/ANKRD17/CKS1B/UBE2C/NUSAP1/RHOA 28 GO:0001954 positive regulation of cell-matrix adhesion 8/1115 58/18722 0.0209487558407705 0.115498432681209 DAG1/UTRN/CDK6/IQGAP1/NRP1/ROCK1/FERMT1/S100A10 8 GO:0035904 aorta development 8/1115 58/18722 0.0209487558407705 0.115498432681209 LRP2/ADAMTS6/LRP1/HECTD1/JAG1/RBPJ/BMPR1A/PKD2 8 GO:0042743 hydrogen peroxide metabolic process 8/1115 58/18722 0.0209487558407705 0.115498432681209 EGFR/PRDX1/PRDX4/GPX3/ACOX1/CAT/PRDX3/SOD1 8 GO:2000736 regulation of stem cell differentiation 8/1115 58/18722 0.0209487558407705 0.115498432681209 N4BP2L2/PRKDC/LTBP3/JAG1/DHX36/CDK12/REST/CDK13 8 GO:0006623 protein targeting to vacuole 6/1115 37/18722 0.0209623489919632 0.115498432681209 VPS13C/SCARB2/GCC2/GNPTAB/LAMP2/VPS13A 6 GO:0010594 regulation of endothelial cell migration 22/1115 232/18722 0.0211258890316542 0.11627950674227 MET/NRP2/GRN/ANXA1/NRP1/LGMN/ATP2B4/PLPP3/NF1/SERPINF1/P2RX4/NR2F2/ADAM17/PTPRM/BMPR2/TMSB4X/HSPB1/FOXP1/EMC10/AKT3/HMGB1/RHOA 22 GO:0007605 sensory perception of sound 16/1115 154/18722 0.0213454943717301 0.117246496348423 LRP2/NIPBL/PGAP1/TBL1X/HEXB/ATP6V1B1/USP53/SCARB2/RPL38/SLC1A3/MYO7A/MYO6/NAV2/WFS1/BIRC5/SOD1 16 GO:0051168 nuclear export 16/1115 154/18722 0.0213454943717301 0.117246496348423 HNRNPA1/NPM1/TPR/SRSF3/YWHAE/SMG1/PTPN14/AKAP13/NEMF/TCF7L2/THOC2/AHCYL1/SETD2/HNRNPA2B1/RAN/RANBP17 16 GO:0034101 erythrocyte homeostasis 14/1115 129/18722 0.0214998698731347 0.117973078368619 CDK6/RPS6/PRDX1/ZFP36L1/TGFBR3/PRKDC/RPS17/SLC11A2/UFL1/IREB2/PTBP3/MAPK14/P4HTM/HSPA1A 14 GO:0051402 neuron apoptotic process 23/1115 246/18722 0.0217050807939118 0.118573904772037 GAPDH/LRP1/GRN/NRP1/LGMN/APP/NF1/ERBB3/HSP90AB1/RASA1/USP53/HSPA5/PRKCI/NCSTN/CPEB4/CLN3/XIAP/OXR1/ISL1/CTNNB1/WFS1/RHOA/SOD1 23 GO:0048660 regulation of smooth muscle cell proliferation 18/1115 180/18722 0.0217201210638867 0.118573904772037 EGFR/GJA1/PRKDC/SF1/GNA12/GSTP1/ADAMTS1/TCF7L2/SKP2/BMPR2/FOXP1/S1PR2/PDGFD/BMPR1A/FGFR2/CTNNB1/RHOA/HPGD 18 GO:0071897 DNA biosynthetic process 18/1115 180/18722 0.0217201210638867 0.118573904772037 HNRNPA1/GJA1/PTGES3/HSP90AB1/TNKS2/REV3L/PKIB/BMPR2/XRN1/DCP2/HNRNPA2B1/HNRNPC/ATM/USP10/CTNNB1/USP43/HNRNPD/CCT3 18 GO:0021954 central nervous system neuron development 10/1115 81/18722 0.0217426208600532 0.118573904772037 NRP2/NRP1/MYCBP2/HSP90AB1/B4GALT5/SCYL2/NFIB/TSKU/FGFR2/RAPGEF2 10 GO:0030641 regulation of cellular pH 10/1115 81/18722 0.0217426208600532 0.118573904772037 GRN/SLC9A1/ATP6AP1/TMEM106B/SLC4A2/CLN5/TTPA/CLCN3/CLN3/ATP6V0A1 10 GO:1903533 regulation of protein targeting 10/1115 81/18722 0.0217426208600532 0.118573904772037 TCAF1/LMAN1/ANK3/MYO1C/FZD5/UBE2L3/NPEPPS/SREBF2/STOM/ERBB2 10 GO:0007589 body fluid secretion 11/1115 93/18722 0.0221756804989224 0.120689050136337 EGFR/PRLR/COPA/KCNN4/SLC29A1/WNK1/DDR1/CAV1/CCND1/ANXA2/GPAT4 11 GO:1901796 regulation of signal transduction by p53 class mediator 11/1115 93/18722 0.0221756804989224 0.120689050136337 RPS20/RPL23/NPM1/RPL5/MIF/CD74/RPL26/RRM2B/EIF5A/ATM/PLA2R1 11 GO:0031098 stress-activated protein kinase signaling cascade 23/1115 247/18722 0.0226369841253261 0.122838419330684 EGFR/IGF1R/HACD3/PRDX1/APP/ZFP36L1/PPIA/ARL6IP5/RB1CC1/NCOR1/TAOK1/DLG1/RNF13/GSTP1/TRPV4/TAOK3/EMC10/HMGB1/MAPK14/TLR3/DNAJA1/LTBR/RHOA 23 GO:0032527 protein exit from endoplasmic reticulum 7/1115 48/18722 0.0226396337556459 0.122838419330684 HSP90B1/TMEM30A/SEL1L/ERLEC1/GCC2/HM13/TMEM30B 7 GO:0048146 positive regulation of fibroblast proliferation 7/1115 48/18722 0.0226396337556459 0.122838419330684 CDK6/MIF/CD74/PRKDC/FN1/PDGFD/ANXA2 7 GO:0051028 mRNA transport 14/1115 130/18722 0.022823955143313 0.123712788335176 HNRNPA1/ZFP36L1/TPR/MYO1C/SRSF3/RANBP2/SMG1/THOC2/LRPPRC/SETD2/HNRNPA2B1/RANBP17/EIF5A/HNRNPA3 14 GO:0034599 cellular response to oxidative stress 26/1115 288/18722 0.0229240149581619 0.124129123591913 EGFR/MET/ANXA1/PRDX1/PPIA/RPS3/BMP7/ARL6IP5/ATP2A2/NET1/P4HB/CHCHD2/HSPB1/CHD6/GPX8/NFE2L1/PTPRK/PDGFD/OXR1/PKD2/REST/CTNNB1/HSPA1A/PLA2R1/PRDX3/SOD1 26 GO:0006767 water-soluble vitamin metabolic process 8/1115 59/18722 0.0230131277281925 0.124356945972748 SLC2A1/SLC52A1/SLC19A1/SLC19A3/FOLR1/LMBRD1/MTR/SLC52A2 8 GO:0009314 response to radiation 38/1115 456/18722 0.023063161665579 0.124356945972748 EGFR/ITGB1/MME/ANXA1/LRP5/NPM1/APP/NIPBL/NF1/PRKDC/ADIRF/CDS1/USP47/GNAQ/DNMT3A/RPL26/DDB1/NET1/HSPA5/MEIS2/SLC1A3/SMPD1/TP53I13/F11R/PIAS1/DHX36/SCARA3/PTPRK/MAPK14/OPN3/CCND1/UBE4B/ITGB6/CAT/CREBBP/ATM/EEF1D/TRIM13 38 GO:0051056 regulation of small GTPase mediated signal transduction 27/1115 302/18722 0.0231838857985929 0.124356945972748 ADGRG1/MET/ITGB1/KANK1/ITGAV/NRP1/ABCA1/ARHGAP5/DOCK8/ARHGAP21/RASA1/ARFGEF1/NET1/ARHGAP18/AKAP13/ARHGAP28/DENND4C/AMOT/ARHGAP29/ARFGEF3/F11R/VAV3/ARHGAP32/ARHGAP23/CYTH3/CCDC125/CDC42SE1 27 GO:0001945 lymph vessel development 5/1115 28/18722 0.0232282196141912 0.124356945972748 SVEP1/PTPN14/NR2F2/BMPR2/ACVR2B 5 GO:0006516 glycoprotein catabolic process 5/1115 28/18722 0.0232282196141912 0.124356945972748 EDEM3/STT3B/MANBA/GPC1/MAN1B1 5 GO:0010464 regulation of mesenchymal cell proliferation 5/1115 28/18722 0.0232282196141912 0.124356945972748 LRP5/NFIB/BMPR1A/FGFR2/CTNNB1 5 GO:0032607 interferon-alpha production 5/1115 28/18722 0.0232282196141912 0.124356945972748 DHX36/SETD2/HMGB1/TLR3/MAVS 5 GO:0032647 regulation of interferon-alpha production 5/1115 28/18722 0.0232282196141912 0.124356945972748 DHX36/SETD2/HMGB1/TLR3/MAVS 5 GO:0032801 receptor catabolic process 5/1115 28/18722 0.0232282196141912 0.124356945972748 RNF43/LGMN/ZNRF3/FURIN/ANXA2 5 GO:0090344 negative regulation of cell aging 5/1115 28/18722 0.0232282196141912 0.124356945972748 CDK6/MIF/PRKDC/YBX1/AKT3 5 GO:1903020 positive regulation of glycoprotein metabolic process 5/1115 28/18722 0.0232282196141912 0.124356945972748 ARFGEF1/TCF7L2/NCSTN/ALG10B/CTNNB1 5 GO:0034219 carbohydrate transmembrane transport 13/1115 118/18722 0.0233806698908718 0.124356945972748 SLC2A1/SLC5A3/SLC17A5/PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/SLC2A8/INSR/OCLN/GPC3 13 GO:0038061 NIK/NF-kappaB signaling 15/1115 143/18722 0.0234144414723026 0.124356945972748 EGFR/PRDX1/APP/DICER1/NFAT5/RPS3/BMP7/ACTN4/TRIM44/TMSB4X/HMGB1/REL/TLR3/RC3H1/RHOA 15 GO:0001558 regulation of cell growth 35/1115 414/18722 0.0234869253800126 0.124356945972748 EGFR/LRP1/SEMA6D/GOLGA4/NRP1/NPM1/SEMA6A/MACF1/RTN4/SEMA3F/GJA1/SMARCA2/NRCAM/CDKL5/KIAA1109/ADAM10/USP47/ENO1/SLC9A1/NET1/FN1/TGFBR1/RYK/SEMA4B/CLSTN1/SERTAD2/ADAM17/BMPR2/DDR1/JADE1/SEMA7A/ITSN2/ERBB2/HSPA1A/RHOA 35 GO:0016575 histone deacetylation 10/1115 82/18722 0.0234888646208427 0.124356945972748 NIPBL/TBL1X/MORF4L2/KDM5A/MIER1/TBL1XR1/REST/ELK4/MORF4L1/RCOR3 10 GO:0060395 SMAD protein signal transduction 10/1115 82/18722 0.0234888646208427 0.124356945972748 LRP1/SPTBN1/BMP7/TGFBR1/NCEH1/BMPR2/SMAD2/BMPR1A/ITGB6/SUB1 10 GO:0030336 negative regulation of cell migration 30/1115 344/18722 0.0236172674652634 0.124356945972748 LRP1/DAG1/CDH1/ADGRG1/TCAF1/SEMA6D/KANK1/ATP2B4/MIF/DPP4/CD74/NF1/GJA1/SERPINF1/DLG5/GNA12/GSTP1/JAG1/NR2F2/PTPRM/MIA3/WASL/NISCH/HMGB1/S1PR2/PTPRK/OSBPL8/BMPR1A/SRGAP1/RHOA 30 GO:0006670 sphingosine metabolic process 4/1115 19/18722 0.0236484342285659 0.124356945972748 ASAH1/PLPP3/SGPP1/SPTLC3 4 GO:0010002 cardioblast differentiation 4/1115 19/18722 0.0236484342285659 0.124356945972748 RBPJ/DHX36/REST/ISL1 4 GO:0015802 basic amino acid transport 4/1115 19/18722 0.0236484342285659 0.124356945972748 SLC38A9/SLC7A6/SLC7A2/CLN3 4 GO:0031290 retinal ganglion cell axon guidance 4/1115 19/18722 0.0236484342285659 0.124356945972748 NRP1/RPL24/PTPRM/ISL1 4 GO:0035728 response to hepatocyte growth factor 4/1115 19/18722 0.0236484342285659 0.124356945972748 NRP1/LGMN/GAB1/APPL1 4 GO:0044003 modulation by symbiont of host process 4/1115 19/18722 0.0236484342285659 0.124356945972748 DAG1/ANO6/INSR/SERPINB9 4 GO:0045947 negative regulation of translational initiation 4/1115 19/18722 0.0236484342285659 0.124356945972748 RPL13A/TPR/AGO2/PAIP2 4 GO:0046716 muscle cell cellular homeostasis 4/1115 19/18722 0.0236484342285659 0.124356945972748 GAA/ALDOA/DMD/SOD1 4 GO:0061323 cell proliferation involved in heart morphogenesis 4/1115 19/18722 0.0236484342285659 0.124356945972748 RBPJ/BMPR2/ISL1/CTNNB1 4 GO:2000369 regulation of clathrin-dependent endocytosis 4/1115 19/18722 0.0236484342285659 0.124356945972748 AAK1/SCYL2/WASL/DNAJC6 4 GO:1901215 negative regulation of neuron death 20/1115 208/18722 0.0236746324761016 0.124356945972748 LRP1/GRN/NRP1/LGMN/ERBB3/SERPINF1/HSP90AB1/RASA1/PRKCI/TMEM259/CPEB4/CLN3/OXR1/REL/REST/ISL1/CTNNB1/WFS1/RHOA/SOD1 20 GO:2000279 negative regulation of DNA biosynthetic process 6/1115 38/18722 0.0236775637344637 0.124356945972748 HNRNPA1/GJA1/BMPR2/XRN1/DCP2/HNRNPC 6 GO:0001764 neuron migration 16/1115 156/18722 0.0237774281844279 0.124356945972748 ADGRG1/NRP2/NRP1/SEMA6A/NIPBL/NRCAM/CDKL5/PLXNB2/USP9X/PCM1/TOP2B/NR2F2/ZNF609/FZD3/RAPGEF2/CTNNB1 16 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 11/1115 94/18722 0.023813182028673 0.124356945972748 EGFR/NR2F2/LATS2/ADAM17/IPO7/CCND1/ACTB/PKD2/CKS1B/CDKN1C/CDKN3 11 GO:0070302 regulation of stress-activated protein kinase signaling cascade 19/1115 195/18722 0.0238767904031949 0.124356945972748 EGFR/IGF1R/PRDX1/APP/PPIA/ARL6IP5/RB1CC1/NCOR1/TAOK1/DLG1/RNF13/GSTP1/TRPV4/TAOK3/EMC10/HMGB1/TLR3/DNAJA1/LTBR 19 GO:0031214 biomineral tissue development 17/1115 169/18722 0.0239538429789268 0.124356945972748 FBN2/ATP2B1/LGR4/ANO6/BMP7/ANKH/LTBP3/ROCK1/SLC4A2/KLF10/BMPR2/BMPR1A/ITGB6/FGFR2/GPC3/ACVR2B/ATRAID 17 GO:0010466 negative regulation of peptidase activity 24/1115 262/18722 0.0240632806375919 0.124356945972748 GAPDH/SPINT1/CRIM1/LRP1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/USP47/BIRC6/ROCK1/IFI6/SIAH2/DHCR24/CAST/XIAP/ANXA2/SERPINB9/GPC3/BIRC5/PRDX3/SERPINB1 24 GO:0031330 negative regulation of cellular catabolic process 24/1115 262/18722 0.0240632806375919 0.124356945972748 MET/RPL23/RPL5/ATP2B4/YBX1/FURIN/HSP90AB1/USP25/SMG1/ROCK1/NPC1/LRPPRC/SMARCC1/CTSA/DHX36/MAPK14/TAB2/HNRNPC/ANXA2/EIF3H/ATRAID/HNRNPD/FUS/YBX3 24 GO:0019827 stem cell population maintenance 14/1115 131/18722 0.0242080376316408 0.124356945972748 TPT1/LRP5/NIPBL/NCOA3/BMP7/RIF1/JAG1/ZC3H13/PCM1/KLF10/RBPJ/BMPR1A/REST/CTNNB1 14 GO:0001765 membrane raft assembly 3/1115 11/18722 0.0242424780678562 0.124356945972748 S100A10/CAV1/ANXA2 3 GO:0003139 secondary heart field specification 3/1115 11/18722 0.0242424780678562 0.124356945972748 LRP2/RBPJ/ISL1 3 GO:0003174 mitral valve development 3/1115 11/18722 0.0242424780678562 0.124356945972748 GJA5/BMPR2/BMPR1A 3 GO:0009313 oligosaccharide catabolic process 3/1115 11/18722 0.0242424780678562 0.124356945972748 HEXB/MANBA/GM2A 3 GO:0019048 modulation by virus of host process 3/1115 11/18722 0.0242424780678562 0.124356945972748 DAG1/ANO6/INSR 3 GO:0021561 facial nerve development 3/1115 11/18722 0.0242424780678562 0.124356945972748 NRP2/NRP1/SEMA3F 3 GO:0021604 cranial nerve structural organization 3/1115 11/18722 0.0242424780678562 0.124356945972748 NRP2/NRP1/SEMA3F 3 GO:0021610 facial nerve morphogenesis 3/1115 11/18722 0.0242424780678562 0.124356945972748 NRP2/NRP1/SEMA3F 3 GO:0032329 serine transport 3/1115 11/18722 0.0242424780678562 0.124356945972748 SLC38A2/SLC1A5/SERINC3 3 GO:0046598 positive regulation of viral entry into host cell 3/1115 11/18722 0.0242424780678562 0.124356945972748 CD74/P4HB/TRIM38 3 GO:0060379 cardiac muscle cell myoblast differentiation 3/1115 11/18722 0.0242424780678562 0.124356945972748 RBPJ/REST/ISL1 3 GO:0061314 Notch signaling involved in heart development 3/1115 11/18722 0.0242424780678562 0.124356945972748 GALNT11/JAG1/RBPJ 3 GO:0071044 histone mRNA catabolic process 3/1115 11/18722 0.0242424780678562 0.124356945972748 XRN1/DCP2/ATM 3 GO:0072110 glomerular mesangial cell proliferation 3/1115 11/18722 0.0242424780678562 0.124356945972748 BMP7/PDGFD/CFLAR 3 GO:0075294 positive regulation by symbiont of entry into host 3/1115 11/18722 0.0242424780678562 0.124356945972748 CD74/P4HB/TRIM38 3 GO:0097050 type B pancreatic cell apoptotic process 3/1115 11/18722 0.0242424780678562 0.124356945972748 TCF7L2/CAST/WFS1 3 GO:1903897 regulation of PERK-mediated unfolded protein response 3/1115 11/18722 0.0242424780678562 0.124356945972748 HSPA5/TMEM33/PPP1R15B 3 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 3/1115 11/18722 0.0242424780678562 0.124356945972748 LRP1/CD74/HMGB1 3 GO:0010506 regulation of autophagy 28/1115 317/18722 0.0242471587858459 0.124356945972748 GAPDH/MET/EEF1A1/PSAP/ATP6V1B1/VPS13C/ATF6/SMG1/ROCK1/UFL1/FZD5/VDAC1/NPC1/C9orf72/HSPB1/CTSA/RAB3GAP1/CLN3/HMGB1/SOGA1/RAB3GAP2/SREBF2/TAB2/TRIM38/ATP6V0A1/ATM/USP10/TRIM13 28 GO:0003002 regionalization 29/1115 331/18722 0.0243741174644505 0.124888112421018 LRP2/ADGRG1/NRP2/LRP5/WLS/NRP1/PBX1/PGAP1/SEMA3F/PRKDC/BPTF/TGFBR1/FZD5/NR2F2/RBPJ/GLI3/BMPR2/MIB1/SMAD2/COBL/AHI1/BMPR1A/TRA2B/FGFR2/ISL1/GPC3/ACVR2B/CTNNB1/IRX2 29 GO:0000281 mitotic cytokinesis 9/1115 71/18722 0.0245694999363301 0.125648046130332 SON/ANK3/SPTBN1/RASA1/SNX18/ROCK1/MYH10/NUSAP1/RHOA 9 GO:0061515 myeloid cell development 9/1115 71/18722 0.0245694999363301 0.125648046130332 FBN1/RPS6/APP/SLC11A2/ATP6AP1/PTBP3/FOXP1/ANXA2/WASF2 9 GO:0001837 epithelial to mesenchymal transition 16/1115 157/18722 0.0250689137346958 0.127876905697654 DAG1/RTN4/TGFBR3/GCNT2/DDX17/BMP7/DLG5/JAG1/ROCK1/TGFBR1/TCF7L2/RBPJ/SMAD2/FGFR2/ISL1/CTNNB1 16 GO:0035088 establishment or maintenance of apical/basal cell polarity 7/1115 49/18722 0.0251011420062074 0.127876905697654 DLG5/DLG1/FAT1/PRKCI/PTK7/ARF4/RHOA 7 GO:0038084 vascular endothelial growth factor signaling pathway 7/1115 49/18722 0.0251011420062074 0.127876905697654 NRP2/FLT1/NRP1/SEMA6A/MYO1C/GAB1/HSPB1 7 GO:0061245 establishment or maintenance of bipolar cell polarity 7/1115 49/18722 0.0251011420062074 0.127876905697654 DLG5/DLG1/FAT1/PRKCI/PTK7/ARF4/RHOA 7 GO:0060038 cardiac muscle cell proliferation 8/1115 60/18722 0.025216463677231 0.128341944301941 GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 8 GO:0048678 response to axon injury 10/1115 83/18722 0.0253341167787637 0.128742416371973 LRP1/DAG1/GRN/PTPRF/P2RX4/FOLR1/MTR/ISL1/ARF4/SOD1 10 GO:0010927 cellular component assembly involved in morphogenesis 12/1115 107/18722 0.0253433750902684 0.128742416371973 DAG1/KRT19/ITGB1/KRT8/ITGB4/DICER1/ACTG1/PLEC/AKAP13/GPC1/CFLAR/OBSL1 12 GO:0045637 regulation of myeloid cell differentiation 20/1115 210/18722 0.0259072452640738 0.131481732381074 FBN1/CSF3R/CDK6/ZFP36L1/SCIN/CD74/PRKDC/ATP6AP1/JAG1/MEIS2/KLF10/TMEM64/PURB/FOXP1/HMGB1/MAPK14/P4HTM/TLR3/CTNNB1/HSPA1A 20 GO:0043524 negative regulation of neuron apoptotic process 15/1115 145/18722 0.0261491999386605 0.132583645273037 LRP1/GRN/NRP1/LGMN/ERBB3/HSP90AB1/RASA1/PRKCI/CPEB4/CLN3/OXR1/ISL1/WFS1/RHOA/SOD1 15 GO:0010952 positive regulation of peptidase activity 19/1115 197/18722 0.0262075599374499 0.13275347486342 GRN/FBLN1/LGMN/APP/ASPH/CTSD/RPS3/ARL6IP5/FN1/NCSTN/CLDN4/HMGB1/CFLAR/CAV1/REST/CYFIP2/CYCS/HSPE1/RHOA 19 GO:0048659 smooth muscle cell proliferation 18/1115 184/18722 0.0264088007268654 0.133646054104962 EGFR/GJA1/PRKDC/SF1/GNA12/GSTP1/ADAMTS1/TCF7L2/SKP2/BMPR2/FOXP1/S1PR2/PDGFD/BMPR1A/FGFR2/CTNNB1/RHOA/HPGD 18 GO:0110148 biomineralization 17/1115 171/18722 0.0264868493710952 0.133914099235111 FBN2/ATP2B1/LGR4/ANO6/BMP7/ANKH/LTBP3/ROCK1/SLC4A2/KLF10/BMPR2/BMPR1A/ITGB6/FGFR2/GPC3/ACVR2B/ATRAID 17 GO:0034314 Arp2/3 complex-mediated actin nucleation 6/1115 39/18722 0.0266185927882952 0.134137631498574 IQGAP2/NCKAP1/WASL/ARPC3/ABI2/WASF2 6 GO:0051084 'de novo' posttranslational protein folding 6/1115 39/18722 0.0266185927882952 0.134137631498574 CD74/PTGES3/DNAJB14/HSPA5/HSPA1A/HSPE1 6 GO:0000271 polysaccharide biosynthetic process 9/1115 72/18722 0.0266505181409541 0.134137631498574 AGL/PTGES3/CLTC/B4GALT5/B3GNT2/B3GNT3/EPM2AIP1/SORBS1/INSR 9 GO:0001707 mesoderm formation 9/1115 72/18722 0.0266505181409541 0.134137631498574 ITGB1/ITGB4/WLS/GJA1/BMP7/BMPR2/SMAD2/BMPR1A/FGFR2 9 GO:0010632 regulation of epithelial cell migration 26/1115 292/18722 0.0266661517065073 0.134137631498574 MET/NRP2/GRN/ANXA1/PFN1/NRP1/LGMN/MACF1/ATP2B4/RTN4/PLPP3/NF1/SERPINF1/P2RX4/NR2F2/ADAM17/PTPRM/BMPR2/TMSB4X/HSPB1/FOXP1/EMC10/AKT3/HMGB1/CAPN7/RHOA 26 GO:0001773 myeloid dendritic cell activation 5/1115 29/18722 0.0267320546758725 0.134137631498574 ITGB8/RBPJ/HMGB1/ITGB6/LTBR 5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 5/1115 29/18722 0.0267320546758725 0.134137631498574 EGFR/ADAM17/CCND1/PKD2/CKS1B 5 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 5/1115 29/18722 0.0267320546758725 0.134137631498574 MIF/CD74/RPL26/RRM2B/EIF5A 5 GO:0009895 negative regulation of catabolic process 28/1115 320/18722 0.0269921625552077 0.13531563932606 EGFR/MET/RPL23/RPL5/MYCBP2/ATP2B4/YBX1/FURIN/HSP90AB1/USP25/MDM4/NCOR1/SMG1/ROCK1/NPC1/LRPPRC/SMARCC1/CTSA/DHX36/MAPK14/TAB2/HNRNPC/ANXA2/EIF3H/ATRAID/HNRNPD/FUS/YBX3 28 GO:0043491 protein kinase B signaling 20/1115 211/18722 0.0270818247647946 0.135637769624051 EGFR/LRP2/DAG1/MET/ITGB1/IGF1R/RTN4/ZFP36L1/GCNT2/P2RX4/HSP90AB1/ARFGEF1/DLG1/TGFBR1/TCF7L2/RICTOR/TPBG/C1QTNF1/OSBPL8/INSR 20 GO:0006112 energy reserve metabolic process 10/1115 84/18722 0.0272810922870847 0.136252340243915 IL6ST/AGL/GAA/PTGES3/PHKB/RB1CC1/EPM2AIP1/SORBS1/HMGB1/INSR 10 GO:0010921 regulation of phosphatase activity 10/1115 84/18722 0.0272810922870847 0.136252340243915 HSP90B1/SLC39A10/BOD1L1/CALM1/HSP90AB1/ROCK1/PPP6R2/PPP1R12A/PPP6R3/PPP1R15B 10 GO:0042310 vasoconstriction 10/1115 84/18722 0.0272810922870847 0.136252340243915 EGFR/ATP2B1/SLC6A4/GJA1/GJA5/BMPR2/CAV1/ZDHHC21/EDNRB/RHOA 10 GO:0030510 regulation of BMP signaling pathway 11/1115 96/18722 0.0273494796037072 0.136338815690189 FBN1/LRP2/CRIM1/FSTL1/TRIM33/RBPJ/BMPR2/SMAD2/XIAP/SMURF2/GPC3 11 GO:0034620 cellular response to unfolded protein 11/1115 96/18722 0.0273494796037072 0.136338815690189 ATF6/ERLEC1/CREB3L2/UFL1/HSPA5/AMFR/TMEM33/CCND1/PPP1R15B/HSPA1A/WFS1 11 GO:0040014 regulation of multicellular organism growth 8/1115 61/18722 0.0275628458473582 0.137146350399856 LGMN/APP/ADRB1/NIPBL/TNKS2/CELF1/GPAT4/SOD1 8 GO:2000401 regulation of lymphocyte migration 8/1115 61/18722 0.0275628458473582 0.137146350399856 APP/DOCK8/ADAM10/ADAM17/WNK1/MIA3/WASL/RHOA 8 GO:0001961 positive regulation of cytokine-mediated signaling pathway 7/1115 50/18722 0.0277396777214168 0.137641393452271 CD74/TRIM44/PARP14/ADAM17/AGPAT1/MAVS/HSPA1A 7 GO:0043268 positive regulation of potassium ion transport 7/1115 50/18722 0.0277396777214168 0.137641393452271 AKAP9/ANO6/DLG1/KCNN4/KIF5B/WNK1/ALG10B 7 GO:0060688 regulation of morphogenesis of a branching structure 7/1115 50/18722 0.0277396777214168 0.137641393452271 LGR4/RTN4/MAGED1/BMP7/BTBD7/FGFR2/CTNNB1 7 GO:0042770 signal transduction in response to DNA damage 17/1115 172/18722 0.0278262545352488 0.137942778982074 NPM1/MIF/ATRX/CD74/PRKDC/RPL26/MDM4/TAOK1/TAOK3/MAPK14/CCND1/FEM1B/MYO6/FOXO4/ATM/USP10/PLA2R1 17 GO:0042391 regulation of membrane potential 36/1115 434/18722 0.0280582447375897 0.138397198966815 AKAP9/DSC2/APP/ADRB1/GABRE/GJA1/CALM1/ANK3/DSG2/ARL6IP5/P2RX4/GNAQ/YWHAE/USP53/SLC9A1/DLG1/ATP2A2/KCNN4/IFI6/KIF5B/GJA5/PPP1R9A/GPD1L/DMD/SLC25A36/ATP1A1/SLC29A1/RAB3GAP1/DSP/CLN3/S1PR2/PKP2/CAV1/PPP3CA/PRDX3/SOD1 36 GO:0038127 ERBB signaling pathway 13/1115 121/18722 0.0280627172531472 0.138397198966815 EGFR/EFEMP1/IQGAP1/LGMN/RTN4/RPS6KA5/GAB1/IFI6/RBPJ/ADAM17/GAREM1/RHBDF1/ARF4 13 GO:0045931 positive regulation of mitotic cell cycle 13/1115 121/18722 0.0280627172531472 0.138397198966815 EGFR/ANXA1/PBX1/LGMN/APP/BRD4/PKN2/ADAMTS1/MEIS2/ADAM17/CCND1/ANKRD17/UBE2C 13 GO:0000272 polysaccharide catabolic process 4/1115 20/18722 0.0282030628349682 0.138397198966815 AGL/GAA/RB1CC1/HMGB1 4 GO:0003159 morphogenesis of an endothelium 4/1115 20/18722 0.0282030628349682 0.138397198966815 RBPJ/FOXP1/CTNNB1/RHOA 4 GO:0032211 negative regulation of telomere maintenance via telomerase 4/1115 20/18722 0.0282030628349682 0.138397198966815 HNRNPA1/XRN1/DCP2/HNRNPC 4 GO:0043011 myeloid dendritic cell differentiation 4/1115 20/18722 0.0282030628349682 0.138397198966815 ITGB8/RBPJ/ITGB6/LTBR 4 GO:0060252 positive regulation of glial cell proliferation 4/1115 20/18722 0.0282030628349682 0.138397198966815 EGFR/UFL1/PRKCI/PLAG1 4 GO:0061154 endothelial tube morphogenesis 4/1115 20/18722 0.0282030628349682 0.138397198966815 RBPJ/FOXP1/CTNNB1/RHOA 4 GO:0072567 chemokine (C-X-C motif) ligand 2 production 4/1115 20/18722 0.0282030628349682 0.138397198966815 LRP1/CD74/FOXP1/HMGB1 4 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 4/1115 20/18722 0.0282030628349682 0.138397198966815 LRP1/CD74/FOXP1/HMGB1 4 GO:0010959 regulation of metal ion transport 34/1115 406/18722 0.028485239546274 0.139653529786554 AHNAK/AKAP9/ATP2B1/ITGB1/UTRN/ATP2B4/PRSS8/GJA1/CALM1/ANO6/ANK3/P2RX4/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KCNN4/KIF5B/VDAC1/AHCYL1/GPD1L/DMD/ATP1A1/WNK1/PKP2/CAV1/STOM/ALG10B/PKD2/VMP1/CTNNB1/WFS1/RHOA 34 GO:0098727 maintenance of cell number 14/1115 134/18722 0.0287350397713297 0.140748970035898 TPT1/LRP5/NIPBL/NCOA3/BMP7/RIF1/JAG1/ZC3H13/PCM1/KLF10/RBPJ/BMPR1A/REST/CTNNB1 14 GO:0071478 cellular response to radiation 18/1115 186/18722 0.0290211807898968 0.142020242197304 MME/NPM1/NIPBL/ADIRF/USP47/RPL26/DDB1/NET1/HSPA5/SMPD1/DHX36/PTPRK/MAPK14/OPN3/ITGB6/CREBBP/ATM/EEF1D 18 GO:0051099 positive regulation of binding 17/1115 173/18722 0.0292156219466343 0.142840847594396 LRP1/MET/NRP1/APP/CALM1/HSP90AB1/TCF7L2/CLN5/AMFR/S100A10/HMGB1/CAV1/RAN/ANXA2/ISL1/RAPGEF2/CTNNB1 17 GO:0032412 regulation of ion transmembrane transporter activity 24/1115 267/18722 0.0292737266264166 0.142993985780822 AHNAK/AKAP9/TCAF1/ITGB1/UTRN/APP/CALM1/ANK3/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KIF5B/AHCYL1/GPD1L/DMD/WNK1/TMSB4X/CAV1/STOM/ALG10B/PKD2/VMP1 24 GO:0032092 positive regulation of protein binding 10/1115 85/18722 0.0293324218384249 0.14314972595553 LRP1/NRP1/APP/HSP90AB1/TCF7L2/AMFR/CAV1/RAN/ANXA2/RAPGEF2 10 GO:0030866 cortical actin cytoskeleton organization 6/1115 40/18722 0.0297918773078637 0.144730512235381 PLEC/DLG1/ROCK1/FMNL2/NCKAP1/RAB13 6 GO:0035329 hippo signaling 6/1115 40/18722 0.0297918773078637 0.144730512235381 TEAD1/DLG5/AMOT/LATS2/WWC2/MAPK14 6 GO:0060412 ventricular septum morphogenesis 6/1115 40/18722 0.0297918773078637 0.144730512235381 TGFBR3/TGFBR1/RBPJ/BMPR2/BMPR1A/FGFR2 6 GO:0097352 autophagosome maturation 6/1115 40/18722 0.0297918773078637 0.144730512235381 CALM1/ATP2A2/SNX14/LAMP2/CLN3/VMP1 6 GO:2000142 regulation of DNA-templated transcription, initiation 6/1115 40/18722 0.0297918773078637 0.144730512235381 ZNF451/MED13/DHX36/HMGB1/ATF7IP/SUB1 6 GO:0032835 glomerulus development 8/1115 62/18722 0.030056154281743 0.145616885399479 LGR4/IQGAP1/ENPEP/BMP7/JAG1/MTSS1/PDGFD/CFLAR 8 GO:0045428 regulation of nitric oxide biosynthetic process 8/1115 62/18722 0.030056154281743 0.145616885399479 ATP2B4/DYNLL1/P2RX4/HSP90AB1/CD47/CAV1/INSR/PKD2 8 GO:0048002 antigen processing and presentation of peptide antigen 8/1115 62/18722 0.030056154281743 0.145616885399479 LGMN/CD74/CTSD/LNPEP/CTSF/ERAP1/TAPBP/MR1 8 GO:0046777 protein autophosphorylation 21/1115 227/18722 0.0302454299244323 0.146089227489075 EGFR/IQGAP1/FLT1/IGF1R/AAK1/CALM1/CDKL5/SMG1/TAOK1/TRPM7/EPHB4/WNK1/DDR1/TAOK3/PDGFD/CAV1/CDK12/INSR/FGFR2/ATM/ERBB2 21 GO:0001101 response to acid chemical 14/1115 135/18722 0.0303737700003476 0.146089227489075 KRT8/ATP2B4/COL4A1/PLEC/DNMT3A/SLC38A9/GSTP1/COL5A2/UFL1/CPEB4/PDGFD/PKD2/HNRNPD/RHOA 14 GO:0051348 negative regulation of transferase activity 24/1115 268/18722 0.0304116415135208 0.146089227489075 LRP5/RPS20/RPL23/NPM1/RPL5/NF1/PPIA/PLEC/BMP7/GNAQ/GSTP1/NR2F2/SMPD1/PKIB/LATS2/WNK1/HSPB1/IPO7/CAV1/PIK3IP1/IBTK/DNAJA1/PRDX3/CDKN1C 24 GO:0045070 positive regulation of viral genome replication 5/1115 30/18722 0.0305551542849169 0.146089227489075 HACD3/PPIA/PKN2/DDB1/TOP2B 5 GO:0051125 regulation of actin nucleation 5/1115 30/18722 0.0305551542849169 0.146089227489075 SCIN/NCKAP1/WASL/ABI2/WASF2 5 GO:0061311 cell surface receptor signaling pathway involved in heart development 5/1115 30/18722 0.0305551542849169 0.146089227489075 GALNT11/JAG1/RBPJ/BMPR1A/CTNNB1 5 GO:0090314 positive regulation of protein targeting to membrane 5/1115 30/18722 0.0305551542849169 0.146089227489075 TCAF1/ANK3/MYO1C/STOM/ERBB2 5 GO:1902751 positive regulation of cell cycle G2/M phase transition 5/1115 30/18722 0.0305551542849169 0.146089227489075 PBX1/NPM1/APP/BRD4/CCND1 5 GO:2000637 positive regulation of gene silencing by miRNA 5/1115 30/18722 0.0305551542849169 0.146089227489075 EGFR/TNRC6B/PUM2/PUM1/AGO2 5 GO:0021872 forebrain generation of neurons 7/1115 51/18722 0.0305600919355742 0.146089227489075 NRP2/NRP1/SCYL2/GLI3/FGFR2/RAPGEF2/RHOA 7 GO:1904659 glucose transmembrane transport 12/1115 110/18722 0.03063281484344 0.146089227489075 SLC2A1/SLC5A3/PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/SLC2A8/INSR/OCLN/GPC3 12 GO:0002903 negative regulation of B cell apoptotic process 3/1115 12/18722 0.03091980278379 0.146089227489075 SLC39A10/CD74/FOXP1 3 GO:0021559 trigeminal nerve development 3/1115 12/18722 0.03091980278379 0.146089227489075 NRP1/SEMA3F/ISL1 3 GO:0031453 positive regulation of heterochromatin assembly 3/1115 12/18722 0.03091980278379 0.146089227489075 TPR/MPHOSPH8/ATF7IP 3 GO:0034333 adherens junction assembly 3/1115 12/18722 0.03091980278379 0.146089227489075 DLG5/ACTB/CTNNB1 3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 3/1115 12/18722 0.03091980278379 0.146089227489075 COL4A2/COL4A1/DDR1 3 GO:0043696 dedifferentiation 3/1115 12/18722 0.03091980278379 0.146089227489075 CDK6/NCOA3/HNRNPD 3 GO:0043697 cell dedifferentiation 3/1115 12/18722 0.03091980278379 0.146089227489075 CDK6/NCOA3/HNRNPD 3 GO:0048548 regulation of pinocytosis 3/1115 12/18722 0.03091980278379 0.146089227489075 CLN3/CAV1/APPL1 3 GO:0060442 branching involved in prostate gland morphogenesis 3/1115 12/18722 0.03091980278379 0.146089227489075 BMP7/FEM1B/FGFR2 3 GO:0061307 cardiac neural crest cell differentiation involved in heart development 3/1115 12/18722 0.03091980278379 0.146089227489075 BMP7/FOLR1/JAG1 3 GO:0061308 cardiac neural crest cell development involved in heart development 3/1115 12/18722 0.03091980278379 0.146089227489075 BMP7/FOLR1/JAG1 3 GO:0070493 thrombin-activated receptor signaling pathway 3/1115 12/18722 0.03091980278379 0.146089227489075 MET/IQGAP2/HPGD 3 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 3/1115 12/18722 0.03091980278379 0.146089227489075 BRD4/CDK12/CDK13 3 GO:0090557 establishment of endothelial intestinal barrier 3/1115 12/18722 0.03091980278379 0.146089227489075 F11R/RAPGEF2/FASN 3 GO:0120263 positive regulation of heterochromatin organization 3/1115 12/18722 0.03091980278379 0.146089227489075 TPR/MPHOSPH8/ATF7IP 3 GO:1904667 negative regulation of ubiquitin protein ligase activity 3/1115 12/18722 0.03091980278379 0.146089227489075 RPS20/RPL23/RPL5 3 GO:1990034 calcium ion export across plasma membrane 3/1115 12/18722 0.03091980278379 0.146089227489075 ATP2B1/CALM1/YWHAE 3 GO:0060326 cell chemotaxis 27/1115 310/18722 0.030972334173362 0.146208039037648 CSF3R/MET/ANXA1/FLT1/NRP1/LGMN/MIF/DPP4/CD74/PPIA/ANO6/PLEC/P2RX4/ADAM10/GSTP1/GAB1/TPBG/ADAM17/WNK1/TRPV4/TMSB4X/HSPB1/VAV3/HMGB1/PDGFD/RAB13/EDNRB 27 GO:0007611 learning or memory 23/1115 255/18722 0.0312468515713253 0.14712399779701 EGFR/ITGB1/MME/LGMN/SLC6A4/APP/NF1/SERPINF1/ARL6IP5/SLC11A2/VLDLR/GM2A/VDAC1/MEIS2/TPBG/NCSTN/AMFR/PIAS1/CLN3/INSR/UBA6/PAIP2/ARF4 23 GO:0043547 positive regulation of GTPase activity 23/1115 255/18722 0.0312468515713253 0.14712399779701 ITGA6/ITGB1/ADRB1/PLXNB1/NF1/DOCK8/SNX13/CDKL5/RASA1/SNX18/NET1/DOCK9/DVL3/EVI5/ARHGAP29/S100A10/F11R/RAB3GAP1/ASAP1/CCDC125/TBC1D2B/ERBB2/RAPGEF2 23 GO:0032642 regulation of chemokine production 11/1115 98/18722 0.03124903792879 0.14712399779701 LRP1/APP/CD74/GSTP1/ADAM17/TRPV4/FOXP1/HMGB1/SUZ12/TLR3/MAVS 11 GO:0009952 anterior/posterior pattern specification 19/1115 201/18722 0.0313802238774197 0.147611467208409 LRP5/WLS/PBX1/PGAP1/PRKDC/BPTF/TGFBR1/FZD5/NR2F2/RBPJ/GLI3/BMPR2/MIB1/SMAD2/COBL/BMPR1A/GPC3/ACVR2B/CTNNB1 19 GO:0034103 regulation of tissue remodeling 10/1115 86/18722 0.0314906443923132 0.147870316983782 EGFR/NF1/SYT7/LTBP3/ATP6AP1/ROCK1/TFRC/SUCO/TMEM64/PPP3CA 10 GO:1903510 mucopolysaccharide metabolic process 10/1115 86/18722 0.0314906443923132 0.147870316983782 ITIH5/CHPF/GNS/GLB1/CLTC/DSE/B3GNT2/CHST11/B3GNT3/CHST14 10 GO:0098876 vesicle-mediated transport to the plasma membrane 14/1115 136/18722 0.0320797053870238 0.150371858701774 GOLGA4/MACF1/ANK3/SPTBN1/KIAA1109/KRT18/CLSTN1/RAB11FIP4/LYPLA1/CMTM6/CLN3/RAB13/ACSL3/RAB31 14 GO:1900180 regulation of protein localization to nucleus 14/1115 136/18722 0.0320797053870238 0.150371858701774 CDH1/NPM1/MAGED1/TPR/HSP90AB1/UBR5/TFRC/FERMT1/LATS2/GLI3/MAPK14/RAN/MAVS/CCT3 14 GO:0050954 sensory perception of mechanical stimulus 17/1115 175/18722 0.0321482487310533 0.150560964890433 LRP2/NIPBL/PGAP1/TBL1X/HEXB/P2RX4/ATP6V1B1/USP53/SCARB2/RPL38/SLC1A3/MYO7A/MYO6/NAV2/WFS1/BIRC5/SOD1 17 GO:0034250 positive regulation of cellular amide metabolic process 16/1115 162/18722 0.0323274927357466 0.151267733318275 NPM1/RPL5/PRKDC/PLXNB2/RPS4X/RPL26/LARP4/RPS9/DNAJC3/DHX36/AGO2/EIF5A/ERBB2/HNRNPD/RHOA/YBX3 16 GO:0030239 myofibril assembly 8/1115 63/18722 0.0327000524234394 0.152877040182787 KRT19/ITGB1/KRT8/ACTG1/PLEC/AKAP13/CFLAR/OBSL1 8 GO:0016051 carbohydrate biosynthetic process 19/1115 202/18722 0.0327847113962107 0.153138735034444 AGL/PTGES3/CLTC/RANBP2/B4GALT1/DDB1/B4GALT5/B3GNT2/TPI1/CHST11/SLC35B4/B3GNT3/EPM2AIP1/SORBS1/CHST14/SOGA1/G6PC3/INSR/ISYNA1 19 GO:0071470 cellular response to osmotic stress 6/1115 41/18722 0.0332032054839462 0.153533808995429 SLC2A1/ZFP36L1/TRPV4/CLN3/PKD2/YBX3 6 GO:0003177 pulmonary valve development 4/1115 21/18722 0.0332431322717206 0.153533808995429 JAG1/GJA5/RBPJ/BMPR2 4 GO:0007350 blastoderm segmentation 4/1115 21/18722 0.0332431322717206 0.153533808995429 NRP2/NRP1/SEMA3F/FZD5 4 GO:0008090 retrograde axonal transport 4/1115 21/18722 0.0332431322717206 0.153533808995429 DST/DYNC1H1/KIF5B/SOD1 4 GO:0033962 P-body assembly 4/1115 21/18722 0.0332431322717206 0.153533808995429 DYNC1H1/CNOT6L/RC3H1/LSM3 4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 4/1115 21/18722 0.0332431322717206 0.153533808995429 NCKAP1/WASL/ABI2/WASF2 4 GO:0045655 regulation of monocyte differentiation 4/1115 21/18722 0.0332431322717206 0.153533808995429 CDK6/ZFP36L1/CD74/FOXP1 4 GO:0046514 ceramide catabolic process 4/1115 21/18722 0.0332431322717206 0.153533808995429 ASAH1/HEXB/HEXA/GM2A 4 GO:0046519 sphingoid metabolic process 4/1115 21/18722 0.0332431322717206 0.153533808995429 ASAH1/PLPP3/SGPP1/SPTLC3 4 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 4/1115 21/18722 0.0332431322717206 0.153533808995429 CD74/DHX36/SEMA7A/MAVS 4 GO:0071498 cellular response to fluid shear stress 4/1115 21/18722 0.0332431322717206 0.153533808995429 PLEC/MTSS1/SREBF2/PKD2 4 GO:0072111 cell proliferation involved in kidney development 4/1115 21/18722 0.0332431322717206 0.153533808995429 BMP7/PDGFD/CFLAR/GPC3 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/1115 21/18722 0.0332431322717206 0.153533808995429 SPINT1/SLC6A4/NF1/SLC16A2 4 GO:0032602 chemokine production 11/1115 99/18722 0.0333403748974242 0.153849837145504 LRP1/APP/CD74/GSTP1/ADAM17/TRPV4/FOXP1/HMGB1/SUZ12/TLR3/MAVS 11 GO:0031103 axon regeneration 7/1115 52/18722 0.0335668721199428 0.154228511401355 LRP1/DAG1/GRN/PTPRF/FOLR1/MTR/ISL1 7 GO:0034204 lipid translocation 7/1115 52/18722 0.0335668721199428 0.154228511401355 ATP10D/ABCA1/ANO6/TMEM30A/KCNN4/TMEM30B/ATP11B 7 GO:0043090 amino acid import 7/1115 52/18722 0.0335668721199428 0.154228511401355 ITGB1/SLC43A2/SLC1A5/ARL6IP5/SLC7A2/SLC1A3/SLC16A2 7 GO:0045010 actin nucleation 7/1115 52/18722 0.0335668721199428 0.154228511401355 IQGAP2/SCIN/NCKAP1/WASL/ARPC3/ABI2/WASF2 7 GO:0072132 mesenchyme morphogenesis 7/1115 52/18722 0.0335668721199428 0.154228511401355 BMP7/MDM4/TGFBR1/RBPJ/SMAD2/BMPR1A/ISL1 7 GO:0051453 regulation of intracellular pH 9/1115 75/18722 0.0336334811015314 0.154269034021543 GRN/SLC9A1/TMEM106B/SLC4A2/CLN5/TTPA/CLCN3/CLN3/ATP6V0A1 9 GO:1903363 negative regulation of cellular protein catabolic process 9/1115 75/18722 0.0336334811015314 0.154269034021543 RPL23/RPL5/FURIN/HSP90AB1/USP25/SMARCC1/ANXA2/EIF3H/ATRAID 9 GO:0019915 lipid storage 10/1115 87/18722 0.0337581999717468 0.154575497126206 ITGAV/PLIN2/ABCA1/HEXB/CDS1/MEST/GM2A/OSBPL8/CAV1/SREBF2 10 GO:2000177 regulation of neural precursor cell proliferation 10/1115 87/18722 0.0337581999717468 0.154575497126206 LRP2/SPINT1/ADGRG1/SLC6A4/NF1/GLI3/SLC16A2/FZD3/CTNNB1/RHOA 10 GO:0045471 response to ethanol 14/1115 137/18722 0.0338542056937064 0.154882265808653 RPL15/ITPR2/DNMT3A/GSTP1/RPL10A/ADCY7/CCND1/FGFR2/CAT/GGH/EEF1B2/RHOA/SOD1/HPGD 14 GO:0043406 positive regulation of MAP kinase activity 12/1115 112/18722 0.0345733769510563 0.157691184684935 EGFR/IQGAP1/FLT1/MAGED1/RPS3/AKAP13/FZD5/DVL3/TAOK3/PDGFD/INSR/ERBB2 12 GO:0030149 sphingolipid catabolic process 5/1115 31/18722 0.0347044656311666 0.157691184684935 ASAH1/HEXB/HEXA/GM2A/SMPD1 5 GO:0043171 peptide catabolic process 5/1115 31/18722 0.0347044656311666 0.157691184684935 ENPEP/LNPEP/TPP1/NPEPPS/ERAP1 5 GO:0051443 positive regulation of ubiquitin-protein transferase activity 5/1115 31/18722 0.0347044656311666 0.157691184684935 RPS2/UBE2L3/SKP1/UBE2C/CDC20 5 GO:0060045 positive regulation of cardiac muscle cell proliferation 5/1115 31/18722 0.0347044656311666 0.157691184684935 TGFBR3/RBPJ/MAPK14/BMPR1A/FGFR2 5 GO:0060148 positive regulation of posttranscriptional gene silencing 5/1115 31/18722 0.0347044656311666 0.157691184684935 EGFR/TNRC6B/PUM2/PUM1/AGO2 5 GO:0060390 regulation of SMAD protein signal transduction 5/1115 31/18722 0.0347044656311666 0.157691184684935 LRP1/SPTBN1/TGFBR1/BMPR2/BMPR1A 5 GO:0070633 transepithelial transport 5/1115 31/18722 0.0347044656311666 0.157691184684935 ACTG1/SLC1A3/AHCYL1/EDNRB/ACTB 5 GO:0014706 striated muscle tissue development 32/1115 384/18722 0.0347442876192568 0.157737884012936 LRP2/ITGB1/GJA1/TGFBR3/PLEC/DSG2/DDX17/BMP7/SLC9A1/AKAP13/GPC1/TGFBR1/GJA5/NR2F2/DMD/JARID2/RBPJ/DSP/LY6E/MAPK14/CFLAR/PKP2/CAV1/MYL6/BMPR1A/OBSL1/PPP3CA/FGFR2/ISL1/CTNNB1/RHOA/YBX3 32 GO:0051216 cartilage development 18/1115 190/18722 0.034818639737935 0.157941136415323 EFEMP1/GLG1/ITGB8/SCIN/BMP7/TRIP11/LTBP3/CREB3L2/TGFBR1/CHST11/NFIB/TRPV4/GLI3/BMPR2/MAPK14/TSKU/BMPR1A/CTNNB1 18 GO:0001885 endothelial cell development 8/1115 64/18722 0.0354979736789159 0.16034152408776 MET/ROCK1/F11R/S1PR2/S1PR3/ZDHHC21/RAPGEF2/FASN 8 GO:0030104 water homeostasis 8/1115 64/18722 0.0354979736789159 0.16034152408776 MET/PLEC/ATP6V1B1/TRPV4/CLDN4/CLN3/ELOVL1/WFS1 8 GO:0048857 neural nucleus development 8/1115 64/18722 0.0354979736789159 0.16034152408776 DYNLL1/CALM1/YWHAE/HSPA5/NFIB/GNB4/ACTB/RHOA 8 GO:0055002 striated muscle cell development 8/1115 64/18722 0.0354979736789159 0.16034152408776 KRT19/ITGB1/KRT8/ACTG1/PLEC/AKAP13/CFLAR/OBSL1 8 GO:0080164 regulation of nitric oxide metabolic process 8/1115 64/18722 0.0354979736789159 0.16034152408776 ATP2B4/DYNLL1/P2RX4/HSP90AB1/CD47/CAV1/INSR/PKD2 8 GO:0006664 glycolipid metabolic process 11/1115 100/18722 0.0355287858107124 0.160345044330848 ITGB8/PGAP1/GLB1/HEXB/HEXA/GM2A/B4GALT5/GPAA1/B3GNT5/SMPD1/FUCA1 11 GO:0055076 transition metal ion homeostasis 14/1115 138/18722 0.035698597537892 0.16097534818818 FTH1/SLC40A1/SLC39A10/APP/SLC11A2/ATP6AP1/SLC30A7/TFRC/IREB2/FBXL5/XIAP/ATP7B/SOD1/FTL 14 GO:0017148 negative regulation of translation 22/1115 245/18722 0.0360491234194556 0.162418793195336 GAPDH/RPL13A/ZFP36L1/YBX1/TNRC6B/RPS3/TPR/ROCK1/IREB2/CNOT6L/CPEB4/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MOV10/NCL/RC3H1/PAIP2/HNRNPD 22 GO:0006809 nitric oxide biosynthetic process 9/1115 76/18722 0.0362175403733347 0.162902652108874 ATP2B4/DYNLL1/P2RX4/HSP90AB1/CD47/GCHFR/CAV1/INSR/PKD2 9 GO:0014855 striated muscle cell proliferation 9/1115 76/18722 0.0362175403733347 0.162902652108874 GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/MAPK14/CFLAR/BMPR1A/FGFR2 9 GO:0034249 negative regulation of cellular amide metabolic process 24/1115 273/18722 0.0366105953253523 0.16453195996806 GAPDH/RPL13A/RTN4/ZFP36L1/YBX1/TNRC6B/RPS3/TPR/ORMDL1/ROCK1/IREB2/CNOT6L/CPEB4/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MOV10/NCL/RC3H1/PAIP2/HNRNPD 24 GO:0071320 cellular response to cAMP 7/1115 53/18722 0.0367641239621097 0.164948196281565 AKAP9/APP/ZFP36L1/ITPR2/HSPA5/PKD2/RAPGEF2 7 GO:0021795 cerebral cortex cell migration 6/1115 42/18722 0.036857688361848 0.164948196281565 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1/RHOA 6 GO:0045214 sarcomere organization 6/1115 42/18722 0.036857688361848 0.164948196281565 KRT19/ITGB1/KRT8/ACTG1/PLEC/AKAP13 6 GO:2000404 regulation of T cell migration 6/1115 42/18722 0.036857688361848 0.164948196281565 APP/DOCK8/ADAM10/ADAM17/WNK1/RHOA 6 GO:2001222 regulation of neuron migration 6/1115 42/18722 0.036857688361848 0.164948196281565 ADGRG1/SEMA6A/NIPBL/PLXNB2/ZNF609/RAPGEF2 6 GO:0008643 carbohydrate transport 15/1115 152/18722 0.0376028702326439 0.167911424785629 SLC2A1/SLC5A3/SLC17A5/SLC35D1/PRKCI/SLC35B4/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/SLC2A8/INSR/OCLN/GPC3 15 GO:0051092 positive regulation of NF-kappaB transcription factor activity 15/1115 152/18722 0.0376028702326439 0.167911424785629 NPM1/APP/PPIA/RPS3/RPS6KA5/TFRC/PRKCI/CFLAR/CAV1/TLR3/TRIM38/CAT/TRIM13/HSPA1A/PRDX3 15 GO:0030216 keratinocyte differentiation 14/1115 139/18722 0.0376141719504798 0.167911424785629 ANXA1/ASAH1/ZFP36L1/NCOA3/EXPH5/PLEC/SGPP1/ST14/JAG1/ROCK1/PALLD/RBPJ/DSP/OPN3 14 GO:1903509 liposaccharide metabolic process 11/1115 101/18722 0.0378161986902804 0.168156044913246 ITGB8/PGAP1/GLB1/HEXB/HEXA/GM2A/B4GALT5/GPAA1/B3GNT5/SMPD1/FUCA1 11 GO:0032872 regulation of stress-activated MAPK cascade 18/1115 192/18722 0.0380177933655049 0.168156044913246 EGFR/IGF1R/PRDX1/APP/PPIA/ARL6IP5/RB1CC1/NCOR1/TAOK1/DLG1/GSTP1/TRPV4/TAOK3/EMC10/HMGB1/TLR3/DNAJA1/LTBR 18 GO:0097193 intrinsic apoptotic signaling pathway 25/1115 288/18722 0.0380558922938774 0.168156044913246 TPT1/MIF/CD74/PPIA/PRKDC/RPS3/ARL6IP5/USP47/SGPP1/RPL26/ENO1/GRINA/SERINC3/P4HB/IFI6/HSPB1/RRM2B/CAV1/DNAJA1/EIF5A/ATM/HSPA1A/WFS1/SOD1/YBX3 25 GO:0003170 heart valve development 8/1115 65/18722 0.0384531090717691 0.168156044913246 HECTD1/MDM4/JAG1/ROCK1/GJA5/RBPJ/BMPR2/BMPR1A 8 GO:0033692 cellular polysaccharide biosynthetic process 8/1115 65/18722 0.0384531090717691 0.168156044913246 AGL/PTGES3/B4GALT5/B3GNT2/B3GNT3/EPM2AIP1/SORBS1/INSR 8 GO:0045453 bone resorption 8/1115 65/18722 0.0384531090717691 0.168156044913246 EGFR/NF1/LTBP3/ATP6AP1/TFRC/TPP1/TMEM64/CTNNB1 8 GO:0001778 plasma membrane repair 3/1115 13/18722 0.0384563646448912 0.168156044913246 SYT7/SMPD1/MYOF 3 GO:0003222 ventricular trabecula myocardium morphogenesis 3/1115 13/18722 0.0384563646448912 0.168156044913246 TGFBR1/RBPJ/BMPR1A 3 GO:0003334 keratinocyte development 3/1115 13/18722 0.0384563646448912 0.168156044913246 EXPH5/PLEC/PALLD 3 GO:0010958 regulation of amino acid import across plasma membrane 3/1115 13/18722 0.0384563646448912 0.168156044913246 ITGB1/SLC43A2/ARL6IP5 3 GO:0015809 arginine transport 3/1115 13/18722 0.0384563646448912 0.168156044913246 SLC38A9/SLC7A2/CLN3 3 GO:0016024 CDP-diacylglycerol biosynthetic process 3/1115 13/18722 0.0384563646448912 0.168156044913246 CDS1/AGPAT1/GPAT4 3 GO:0016246 RNA interference 3/1115 13/18722 0.0384563646448912 0.168156044913246 DICER1/CELF1/AGO2 3 GO:0021554 optic nerve development 3/1115 13/18722 0.0384563646448912 0.168156044913246 RPL24/GLI3/NAV2 3 GO:0021819 layer formation in cerebral cortex 3/1115 13/18722 0.0384563646448912 0.168156044913246 ADGRG1/GLI3/CTNNB1 3 GO:0030497 fatty acid elongation 3/1115 13/18722 0.0384563646448912 0.168156044913246 HACD3/TECR/ELOVL1 3 GO:0034112 positive regulation of homotypic cell-cell adhesion 3/1115 13/18722 0.0384563646448912 0.168156044913246 IL6ST/ANK3/F11R 3 GO:0035331 negative regulation of hippo signaling 3/1115 13/18722 0.0384563646448912 0.168156044913246 DLG5/WWC2/MAPK14 3 GO:0042761 very long-chain fatty acid biosynthetic process 3/1115 13/18722 0.0384563646448912 0.168156044913246 HACD3/TECR/ELOVL1 3 GO:0048820 hair follicle maturation 3/1115 13/18722 0.0384563646448912 0.168156044913246 FERMT1/RBPJ/CTNNB1 3 GO:0051451 myoblast migration 3/1115 13/18722 0.0384563646448912 0.168156044913246 ANXA1/NET1/ROCK1 3 GO:0051481 negative regulation of cytosolic calcium ion concentration 3/1115 13/18722 0.0384563646448912 0.168156044913246 LRP1/ATP2B1/GTF2I 3 GO:0098814 spontaneous synaptic transmission 3/1115 13/18722 0.0384563646448912 0.168156044913246 ITGB1/APP/PPP1R9A 3 GO:1903789 regulation of amino acid transmembrane transport 3/1115 13/18722 0.0384563646448912 0.168156044913246 ITGB1/SLC43A2/ARL6IP5 3 GO:1905269 positive regulation of chromatin organization 3/1115 13/18722 0.0384563646448912 0.168156044913246 TPR/MPHOSPH8/ATF7IP 3 GO:0002053 positive regulation of mesenchymal cell proliferation 4/1115 22/18722 0.0387738859724793 0.168303883908184 LRP5/BMPR1A/FGFR2/CTNNB1 4 GO:0007398 ectoderm development 4/1115 22/18722 0.0387738859724793 0.168303883908184 TPT1/ITGA6/BMPR1A/CTNNB1 4 GO:0032069 regulation of nuclease activity 4/1115 22/18722 0.0387738859724793 0.168303883908184 NPM1/RPS3/HMGB1/HSPA1A 4 GO:0035024 negative regulation of Rho protein signal transduction 4/1115 22/18722 0.0387738859724793 0.168303883908184 MET/ITGB1/KANK1/CCDC125 4 GO:0035089 establishment of apical/basal cell polarity 4/1115 22/18722 0.0387738859724793 0.168303883908184 FAT1/PRKCI/PTK7/RHOA 4 GO:0060965 negative regulation of gene silencing by miRNA 4/1115 22/18722 0.0387738859724793 0.168303883908184 NEAT1/KCNQ1OT1/NCOR1/PPP3CA 4 GO:0071404 cellular response to low-density lipoprotein particle stimulus 4/1115 22/18722 0.0387738859724793 0.168303883908184 ITGB1/ABCA1/NPC1/SREBF2 4 GO:1900120 regulation of receptor binding 4/1115 22/18722 0.0387738859724793 0.168303883908184 PTPRF/NRP1/ATP2A2/ANXA2 4 GO:2000773 negative regulation of cellular senescence 4/1115 22/18722 0.0387738859724793 0.168303883908184 CDK6/PRKDC/YBX1/AKT3 4 GO:0008645 hexose transmembrane transport 12/1115 114/18722 0.0388615984309165 0.168319100774347 SLC2A1/SLC5A3/PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/SLC2A8/INSR/OCLN/GPC3 12 GO:1901800 positive regulation of proteasomal protein catabolic process 12/1115 114/18722 0.0388615984309165 0.168319100774347 HECTD1/RNF217/ZYG11B/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/CSNK1A1/CDC20/HSPA1A 12 GO:0017038 protein import 19/1115 206/18722 0.0388719706414627 0.168319100774347 CDH1/RPL23/TPR/HSP90AB1/UBR5/RANBP2/TNPO1/LAMP2/FERMT1/KPNB1/GLI3/IPO7/MAPK14/RAN/APPL1/RANBP17/PPP3CA/MAVS/IPO9 19 GO:0010827 regulation of glucose transmembrane transport 9/1115 77/18722 0.0389342990313065 0.168452368337233 PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/INSR/OCLN/GPC3 9 GO:0043112 receptor metabolic process 16/1115 166/18722 0.0391617701126663 0.168583202584454 LRP1/ITGB1/RNF43/LGMN/ZNRF3/FURIN/CLTC/LMBRD1/TFRC/SCYL2/AHI1/CAV1/RAB31/INSR/MKLN1/ANXA2 16 GO:0006026 aminoglycan catabolic process 5/1115 32/18722 0.0391855692840059 0.168583202584454 GNS/GLB1/GUSB/FUCA1/NAGLU 5 GO:0021799 cerebral cortex radially oriented cell migration 5/1115 32/18722 0.0391855692840059 0.168583202584454 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1 5 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 5/1115 32/18722 0.0391855692840059 0.168583202584454 BRD4/TCERG1/CDK12/CDK13/CTNNB1 5 GO:0042744 hydrogen peroxide catabolic process 5/1115 32/18722 0.0391855692840059 0.168583202584454 PRDX1/PRDX4/GPX3/CAT/PRDX3 5 GO:0051642 centrosome localization 5/1115 32/18722 0.0391855692840059 0.168583202584454 SYNE2/AKAP9/RANBP2/DLG1/KIF5B 5 GO:0060317 cardiac epithelial to mesenchymal transition 5/1115 32/18722 0.0391855692840059 0.168583202584454 RTN4/TGFBR3/JAG1/TGFBR1/RBPJ 5 GO:0052548 regulation of endopeptidase activity 35/1115 432/18722 0.040129539128305 0.17233963860495 GAPDH/SPINT1/CRIM1/ITIH5/APLP2/LGMN/APP/ASPH/TFPI/SERPINF1/CTSD/RPS3/ARL6IP5/FURIN/USP47/BIRC6/ROCK1/IFI6/NCSTN/SIAH2/DHCR24/HMGB1/CFLAR/CAST/XIAP/REST/ANXA2/CYFIP2/SERPINB9/CYCS/BIRC5/HSPE1/PRDX3/RHOA/SERPINB1 35 GO:0032330 regulation of chondrocyte differentiation 7/1115 54/18722 0.0401555554269635 0.17233963860495 EFEMP1/GLG1/SCIN/LTBP3/TGFBR1/GLI3/CTNNB1 7 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 7/1115 54/18722 0.0401555554269635 0.17233963860495 TEAD1/NR3C1/NFIB/SREBF2/NFATC3/BMPR1A/REST 7 GO:0006458 'de novo' protein folding 6/1115 43/18722 0.0407597408290042 0.174511833429073 CD74/PTGES3/DNAJB14/HSPA5/HSPA1A/HSPE1 6 GO:0010171 body morphogenesis 6/1115 43/18722 0.0407597408290042 0.174511833429073 DAG1/NIPBL/ANKRD11/RAB3GAP1/ARID5B/GPC3 6 GO:0014002 astrocyte development 6/1115 43/18722 0.0407597408290042 0.174511833429073 EGFR/LRP1/GRN/CDK6/APP/NF1 6 GO:0034767 positive regulation of ion transmembrane transport 16/1115 167/18722 0.0410217372785507 0.175453971288646 AKAP9/TCAF1/ITGB1/CALM1/ANO6/ANK3/SLC9A1/ACTN4/KCNN4/KIF5B/DMD/WNK1/TMSB4X/ALG10B/PKD2/VMP1 16 GO:0070997 neuron death 30/1115 361/18722 0.0411385441269363 0.175453971288646 GAPDH/LRP1/GRN/NRP1/LGMN/APP/NF1/ERBB3/SERPINF1/ARL6IP5/HSP90AB1/RASA1/USP53/SLC9A1/HSPA5/PRKCI/NCSTN/TMEM259/CPEB4/DHCR24/CLN3/XIAP/OXR1/REL/REST/ISL1/CTNNB1/WFS1/RHOA/SOD1 30 GO:0034968 histone lysine methylation 12/1115 115/18722 0.0411401333403868 0.175453971288646 ASH1L/ATRX/BRD4/KMT2C/TET2/RIF1/NSD1/JARID2/SETD2/KMT2A/SUZ12/CTNNB1 12 GO:0046916 cellular transition metal ion homeostasis 12/1115 115/18722 0.0411401333403868 0.175453971288646 FTH1/SLC40A1/SLC39A10/APP/SLC11A2/ATP6AP1/SLC30A7/TFRC/IREB2/ATP7B/SOD1/FTL 12 GO:0008406 gonad development 20/1115 221/18722 0.041144104149351 0.175453971288646 LRP2/ADGRG1/ATRX/SF1/PRDX4/ADAMTS1/TGFBR1/HSPA5/KDM5A/NR2F2/RHOBTB3/ZFX/RAB13/CCND1/ARID5B/TLR3/IDH1/EIF2S2/SOD1/YBX3 20 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 10/1115 90/18722 0.0412396381737066 0.175580883739569 HECTD1/RNF217/ZYG11B/PIAS1/RNF19A/CAV1/DDA1/CSNK1A1/CDC20/HSPA1A 10 GO:0034644 cellular response to UV 10/1115 90/18722 0.0412396381737066 0.175580883739569 MME/NPM1/USP47/RPL26/DDB1/SMPD1/DHX36/PTPRK/OPN3/CREBBP 10 GO:0030856 regulation of epithelial cell differentiation 15/1115 154/18722 0.0414526864012259 0.176306226990535 ZFP36L1/NCOA3/KIAA1109/SGPP1/JAG1/ROCK1/F11R/ESRP1/S1PR2/AHI1/CAV1/CCND1/S1PR3/ZDHHC21/CTNNB1 15 GO:0019229 regulation of vasoconstriction 8/1115 66/18722 0.0415683960209193 0.176306226990535 EGFR/ATP2B1/GJA1/GJA5/BMPR2/CAV1/ZDHHC21/RHOA 8 GO:0072678 T cell migration 8/1115 66/18722 0.0415683960209193 0.176306226990535 APP/PLEC/DOCK8/ADAM10/ADAM17/WNK1/F11R/RHOA 8 GO:2000573 positive regulation of DNA biosynthetic process 8/1115 66/18722 0.0415683960209193 0.176306226990535 HNRNPA1/PTGES3/HSP90AB1/TNKS2/PKIB/ATM/CTNNB1/CCT3 8 GO:0035303 regulation of dephosphorylation 13/1115 128/18722 0.041588582585029 0.176306226990535 HSP90B1/SLC39A10/BOD1L1/PPIA/CALM1/HSP90AB1/YWHAE/ROCK1/SMPD1/PPP6R2/PPP1R12A/PPP6R3/PPP1R15B 13 GO:2000116 regulation of cysteine-type endopeptidase activity 21/1115 235/18722 0.0416081374804408 0.176306226990535 LGMN/ASPH/CTSD/RPS3/ARL6IP5/USP47/IFI6/SIAH2/DHCR24/HMGB1/CFLAR/CAST/XIAP/REST/CYFIP2/SERPINB9/CYCS/BIRC5/HSPE1/PRDX3/RHOA 21 GO:0008584 male gonad development 14/1115 141/18722 0.0416638403596373 0.17640225509921 LRP2/ADGRG1/ATRX/SF1/PRDX4/TGFBR1/KDM5A/RHOBTB3/RAB13/CCND1/ARID5B/TLR3/EIF2S2/YBX3 14 GO:0006479 protein methylation 17/1115 181/18722 0.0422464373682766 0.178585692089651 ASH1L/ATRX/BRD4/KMT2C/TET2/RIF1/NSD1/RAB6A/PRMT9/JARID2/SETD2/KMT2A/PCMTD1/SUZ12/CREBBP/CTNNB1/SNRPB 17 GO:0008213 protein alkylation 17/1115 181/18722 0.0422464373682766 0.178585692089651 ASH1L/ATRX/BRD4/KMT2C/TET2/RIF1/NSD1/RAB6A/PRMT9/JARID2/SETD2/KMT2A/PCMTD1/SUZ12/CREBBP/CTNNB1/SNRPB 17 GO:0014013 regulation of gliogenesis 11/1115 103/18722 0.0426953143399076 0.180197852380053 EGFR/LRP2/SPINT1/DAG1/IL6ST/DICER1/NF1/UFL1/PRKCI/PLAG1/CTNNB1 11 GO:0045639 positive regulation of myeloid cell differentiation 11/1115 103/18722 0.0426953143399076 0.180197852380053 ZFP36L1/SCIN/CD74/PRKDC/ATP6AP1/JAG1/KLF10/TMEM64/HMGB1/MAPK14/HSPA1A 11 GO:0016482 cytosolic transport 16/1115 168/18722 0.0429442177433005 0.181105196312386 EEA1/CLTC/VPS13C/SYT7/GCC2/TMEM87A/RAB6A/VPS13A/KIF5B/CLN5/EVI5/HOOK2/HEATR5A/RHOBTB3/MON2/CLN3 16 GO:0048738 cardiac muscle tissue development 21/1115 236/18722 0.0432220037243189 0.181989178142065 LRP2/ITGB1/GJA1/TGFBR3/PLEC/DSG2/BMP7/SLC9A1/AKAP13/TGFBR1/GJA5/JARID2/RBPJ/DSP/LY6E/MAPK14/PKP2/BMPR1A/OBSL1/FGFR2/ISL1 21 GO:0090068 positive regulation of cell cycle process 21/1115 236/18722 0.0432220037243189 0.181989178142065 EGFR/ANXA1/LRP5/PBX1/NPM1/APP/ATRX/BRD4/TPR/PKN2/PHIP/ADAMTS1/DYNC1H1/ADAM17/RANBP1/CCND1/INSR/ANKRD17/UBE2C/NUSAP1/RHOA 21 GO:0015749 monosaccharide transmembrane transport 12/1115 116/18722 0.0435103122801608 0.182770698083225 SLC2A1/SLC5A3/PRKCI/SORBS1/MAPK14/OSBPL8/OPN3/APPL1/SLC2A8/INSR/OCLN/GPC3 12 GO:0030518 intracellular steroid hormone receptor signaling pathway 12/1115 116/18722 0.0435103122801608 0.182770698083225 DDX17/PTGES3/NR3C1/UBR5/NCOR1/UFL1/ARID1A/SKP2/FOXP1/ISL1/DNAJA1/RHOA 12 GO:0035967 cellular response to topologically incorrect protein 12/1115 116/18722 0.0435103122801608 0.182770698083225 DNAJB14/ATF6/ERLEC1/CREB3L2/UFL1/HSPA5/AMFR/TMEM33/CCND1/PPP1R15B/HSPA1A/WFS1 12 GO:0015833 peptide transport 23/1115 264/18722 0.0436587407930837 0.183177794928008 EGFR/LRP1/ANXA1/LRP5/ABCA1/DPP4/CD74/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/SLC13A3/TRPV4/SMAD2/EFNA5/PPP3CA/REST/ISL1/TAPBP 23 GO:0006414 translational elongation 7/1115 55/18722 0.0437444631079246 0.183177794928008 EEF1A1/NEMF/SECISBP2L/LTN1/EIF5A/EEF1D/EEF1B2 7 GO:0031113 regulation of microtubule polymerization 7/1115 55/18722 0.0437444631079246 0.183177794928008 AKAP9/MET/CLIP1/RPS3/CAMSAP2/OCLN/HSPA1A 7 GO:0061614 pri-miRNA transcription by RNA polymerase II 7/1115 55/18722 0.0437444631079246 0.183177794928008 TEAD1/NR3C1/NFIB/SREBF2/NFATC3/BMPR1A/REST 7 GO:0046546 development of primary male sexual characteristics 14/1115 142/18722 0.0438003172089677 0.18326794167608 LRP2/ADGRG1/ATRX/SF1/PRDX4/TGFBR1/KDM5A/RHOBTB3/RAB13/CCND1/ARID5B/TLR3/EIF2S2/YBX3 14 GO:0007498 mesoderm development 13/1115 129/18722 0.0438399038372241 0.183289934680454 ITGB1/ITGB4/WLS/ZFP36L1/GJA1/BMP7/MEST/RPL38/BMPR2/SMAD2/SETD2/BMPR1A/FGFR2 13 GO:0060191 regulation of lipase activity 10/1115 91/18722 0.043966712296301 0.18353929788058 EGFR/LRP1/ANXA1/FLT1/FURIN/GNAQ/FGFR2/PLA2R1/ARF4/RHOA 10 GO:0048333 mesodermal cell differentiation 5/1115 33/18722 0.0440026786452786 0.18353929788058 ITGB1/ITGB4/GJA1/BMPR1A/FGFR2 5 GO:0061842 microtubule organizing center localization 5/1115 33/18722 0.0440026786452786 0.18353929788058 SYNE2/AKAP9/RANBP2/DLG1/KIF5B 5 GO:0000245 spliceosomal complex assembly 9/1115 79/18722 0.0447755263530449 0.185309789796983 LUC7L3/SF1/RBM5/SCAF11/SF3B1/CELF1/SNRPD2/SNRPD1/SRSF9 9 GO:0032272 negative regulation of protein polymerization 9/1115 79/18722 0.0447755263530449 0.185309789796983 KANK1/PFN1/SCIN/SPTBN1/ADD3/ARFGEF1/SPTAN1/KANK4/TMSB4X 9 GO:0003283 atrial septum development 4/1115 23/18722 0.0447974418141291 0.185309789796983 MDM4/GJA5/BMPR2/ISL1 4 GO:0006622 protein targeting to lysosome 4/1115 23/18722 0.0447974418141291 0.185309789796983 SCARB2/GCC2/GNPTAB/LAMP2 4 GO:0021871 forebrain regionalization 4/1115 23/18722 0.0447974418141291 0.185309789796983 ADGRG1/PGAP1/GLI3/TRA2B 4 GO:0035994 response to muscle stretch 4/1115 23/18722 0.0447974418141291 0.185309789796983 SLC9A1/DMD/MAPK14/CTNNB1 4 GO:0036303 lymph vessel morphogenesis 4/1115 23/18722 0.0447974418141291 0.185309789796983 SVEP1/PTPN14/BMPR2/ACVR2B 4 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 4/1115 23/18722 0.0447974418141291 0.185309789796983 CHPF/DSE/CHST11/B3GAT3 4 GO:0071636 positive regulation of transforming growth factor beta production 4/1115 23/18722 0.0447974418141291 0.185309789796983 CD46/FURIN/FERMT1/BMPR1A 4 GO:0006879 cellular iron ion homeostasis 8/1115 67/18722 0.0448465082693186 0.185309789796983 FTH1/SLC40A1/SLC11A2/ATP6AP1/TFRC/IREB2/SOD1/FTL 8 GO:0010517 regulation of phospholipase activity 8/1115 67/18722 0.0448465082693186 0.185309789796983 EGFR/LRP1/ANXA1/FLT1/GNAQ/FGFR2/PLA2R1/ARF4 8 GO:0033673 negative regulation of kinase activity 21/1115 237/18722 0.0448809501753846 0.185309789796983 LRP5/NPM1/NF1/PPIA/PLEC/BMP7/GNAQ/GSTP1/NR2F2/SMPD1/PKIB/LATS2/WNK1/HSPB1/IPO7/CAV1/PIK3IP1/IBTK/DNAJA1/PRDX3/CDKN1C 21 GO:0030521 androgen receptor signaling pathway 6/1115 44/18722 0.044913067615152 0.185309789796983 DDX17/NCOR1/ARID1A/FOXP1/DNAJA1/RHOA 6 GO:0045124 regulation of bone resorption 6/1115 44/18722 0.044913067615152 0.185309789796983 EGFR/NF1/LTBP3/ATP6AP1/TFRC/TMEM64 6 GO:0006006 glucose metabolic process 18/1115 196/18722 0.0450502648846733 0.185589015601289 GAPDH/LRP5/GAA/RANBP2/ENO1/DDB1/TPI1/SLC35B4/EPM2AIP1/SORBS1/NISCH/C1QTNF1/HMGB1/SOGA1/NCOA2/MAPK14/G6PC3/INSR 18 GO:0071674 mononuclear cell migration 18/1115 196/18722 0.0450502648846733 0.185589015601289 ANXA1/FLT1/LGMN/APP/ANO6/PLEC/DOCK8/ADAM10/CD47/ADAM17/WNK1/TRPV4/F11R/MIA3/WASL/HMGB1/PDGFD/RHOA 18 GO:0035051 cardiocyte differentiation 15/1115 156/18722 0.0455753561174043 0.187607421982129 EGFR/ITGB1/TGFBR3/PLEC/BMP7/SLC9A1/FOLR1/AKAP13/JAG1/RBPJ/DHX36/BMPR1A/OBSL1/REST/ISL1 15 GO:0002685 regulation of leukocyte migration 19/1115 210/18722 0.0457464931813556 0.188166815943958 ANXA1/LGMN/APP/MIF/DPP4/CD74/ANO6/DOCK8/P2RX4/ADAM10/CD47/ADAM17/WNK1/TRPV4/MIA3/WASL/HMGB1/PDGFD/RHOA 19 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 13/1115 130/18722 0.0461750092476586 0.18957221518901 LMAN1/PGAP1/USO1/COPA/TRIP11/CREB3L2/TMED4/SEC31A/ERGIC2/MIA3/YIPF4/TMED1/ARF4 13 GO:0010951 negative regulation of endopeptidase activity 22/1115 252/18722 0.0467786044206492 0.18957221518901 GAPDH/SPINT1/CRIM1/ITIH5/APLP2/APP/TFPI/SERPINF1/FURIN/USP47/BIRC6/ROCK1/IFI6/SIAH2/DHCR24/CAST/XIAP/ANXA2/SERPINB9/BIRC5/PRDX3/SERPINB1 22 GO:0061448 connective tissue development 22/1115 252/18722 0.0467786044206492 0.18957221518901 EFEMP1/LRP5/GLG1/ITGB8/SCIN/BMP7/TRIP11/LTBP3/CREB3L2/TGFBR1/CHST11/NFIB/TRPV4/GLI3/BMPR2/MAPK14/PDGFD/TSKU/CFLAR/ARID5B/BMPR1A/CTNNB1 22 GO:0006596 polyamine biosynthetic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 OAZ1/SMS/SAT1 3 GO:0006999 nuclear pore organization 3/1115 14/18722 0.0468338175377981 0.18957221518901 RTN4/TPR/TMEM170A 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/1115 14/18722 0.0468338175377981 0.18957221518901 GJA1/GPAA1/HSPA5 3 GO:0038166 angiotensin-activated signaling pathway 3/1115 14/18722 0.0468338175377981 0.18957221518901 ROCK1/AHCYL1/CAV1 3 GO:0042921 glucocorticoid receptor signaling pathway 3/1115 14/18722 0.0468338175377981 0.18957221518901 PTGES3/NR3C1/ARID1A 3 GO:0043455 regulation of secondary metabolic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 OPN3/APPL1/RAPGEF2 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/1115 14/18722 0.0468338175377981 0.18957221518901 RPL26/ATM/PLA2R1 3 GO:0043558 regulation of translational initiation in response to stress 3/1115 14/18722 0.0468338175377981 0.18957221518901 NPM1/DNAJC3/PPP1R15B 3 GO:0046341 CDP-diacylglycerol metabolic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 CDS1/AGPAT1/GPAT4 3 GO:0046479 glycosphingolipid catabolic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 HEXB/HEXA/GM2A 3 GO:0047484 regulation of response to osmotic stress 3/1115 14/18722 0.0468338175377981 0.18957221518901 TRPV4/CLN3/YBX3 3 GO:0048021 regulation of melanin biosynthetic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 OPN3/APPL1/RAPGEF2 3 GO:0071236 cellular response to antibiotic 3/1115 14/18722 0.0468338175377981 0.18957221518901 RPL23/SLC9A1/HSPA5 3 GO:0072176 nephric duct development 3/1115 14/18722 0.0468338175377981 0.18957221518901 AHI1/PKD2/GPC3 3 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 3/1115 14/18722 0.0468338175377981 0.18957221518901 ATP2B4/AKAP13/CAV1 3 GO:1900376 regulation of secondary metabolite biosynthetic process 3/1115 14/18722 0.0468338175377981 0.18957221518901 OPN3/APPL1/RAPGEF2 3 GO:1901722 regulation of cell proliferation involved in kidney development 3/1115 14/18722 0.0468338175377981 0.18957221518901 BMP7/PDGFD/CFLAR 3 GO:1903894 regulation of IRE1-mediated unfolded protein response 3/1115 14/18722 0.0468338175377981 0.18957221518901 UFL1/HSPA5/TMEM33 3 GO:0071248 cellular response to metal ion 18/1115 197/18722 0.046945062030204 0.189878550135802 EGFR/CDH1/IQGAP1/LGMN/APP/SERPINF1/ANK3/P2RX4/SYT7/HSPA5/AOC1/ADCY7/SMPD1/NCSTN/WNK1/PKD2/FUS/SOD1 18 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 7/1115 56/18722 0.0475337208598998 0.191823534142861 ZFP36L1/TNRC6B/CNOT6L/DHX36/DCP2/AGO2/RC3H1 7 GO:0006687 glycosphingolipid metabolic process 7/1115 56/18722 0.0475337208598998 0.191823534142861 ITGB8/GLB1/HEXB/HEXA/GM2A/B4GALT5/SMPD1 7 GO:0051653 spindle localization 7/1115 56/18722 0.0475337208598998 0.191823534142861 ITGB1/CFL1/GJA1/DYNC1H1/KPNB1/WASL/NUSAP1 7 GO:0071229 cellular response to acid chemical 9/1115 80/18722 0.047904348764314 0.193173200946127 COL4A1/PLEC/DNMT3A/SLC38A9/COL5A2/CPEB4/PDGFD/PKD2/HNRNPD 9 GO:0062207 regulation of pattern recognition receptor signaling pathway 11/1115 105/18722 0.0479913701768625 0.193378056886241 LGR4/RTN4/PUM2/PUM1/HMGB1/CAV1/APPL1/XIAP/TLR3/ANKRD17/HSPA1A 11 GO:1904888 cranial skeletal system development 8/1115 68/18722 0.0482898469812268 0.194434006812044 NIPBL/TGFBR1/CHST11/GLI3/SMAD2/SETD2/FGFR2/CTNNB1 8 GO:0051403 stress-activated MAPK cascade 21/1115 239/18722 0.0483364192286793 0.194474862292328 EGFR/IGF1R/HACD3/PRDX1/APP/ZFP36L1/PPIA/ARL6IP5/RB1CC1/NCOR1/TAOK1/DLG1/GSTP1/TRPV4/TAOK3/EMC10/HMGB1/MAPK14/TLR3/DNAJA1/LTBR 21 GO:0010922 positive regulation of phosphatase activity 5/1115 34/18722 0.0491586506447396 0.19704056741161 SLC39A10/CALM1/HSP90AB1/PPP1R12A/PPP1R15B 5 GO:0048536 spleen development 5/1115 34/18722 0.0491586506447396 0.19704056741161 PBX1/PRKDC/JARID2/ADAM17/RC3H1 5 GO:0048854 brain morphogenesis 5/1115 34/18722 0.0491586506447396 0.19704056741161 SLC6A4/NF1/AKT3/FZD6/FZD3 5 GO:0055094 response to lipoprotein particle 5/1115 34/18722 0.0491586506447396 0.19704056741161 ITGB1/ABCA1/NPC1/MIA3/SREBF2 5 GO:0098751 bone cell development 5/1115 34/18722 0.0491586506447396 0.19704056741161 FBN1/ATP6AP1/FOXP1/ANXA2/WASF2 5 GO:0048538 thymus development 6/1115 45/18722 0.0493206541154588 0.197393532475588 PBX1/PRKDC/TGFBR1/JARID2/CTNNB1/SOD1 6 GO:0048546 digestive tract morphogenesis 6/1115 45/18722 0.0493206541154588 0.197393532475588 NIPBL/GLI3/SMAD2/AHI1/FGFR2/CTNNB1 6 GO:0060349 bone morphogenesis 10/1115 93/18722 0.0497820298181317 0.198793012115935 LRP5/GLG1/TRIP11/LTBP3/TRPV4/GLI3/BMPR2/TSKU/FGFR2/DHRS3 10 GO:0106027 neuron projection organization 10/1115 93/18722 0.0497820298181317 0.198793012115935 IGF1R/LGMN/APP/CFL1/ADAM10/PPP1R9A/WASL/DHX36/INSR/ABI2 10 GO:1901992 positive regulation of mitotic cell cycle phase transition 10/1115 93/18722 0.0497820298181317 0.198793012115935 EGFR/ANXA1/PBX1/APP/BRD4/ADAMTS1/ADAM17/CCND1/ANKRD17/UBE2C 10 GO:0050890 cognition 25/1115 296/18722 0.0498517342111277 0.198922577692983 EGFR/ITGB1/MME/LGMN/SLC6A4/APP/NIPBL/NF1/SERPINF1/ARL6IP5/SLC11A2/VLDLR/GM2A/TUSC3/VDAC1/MEIS2/TPBG/NCSTN/AMFR/PIAS1/CLN3/INSR/UBA6/PAIP2/ARF4 25 GO:0050708 regulation of protein secretion 23/1115 268/18722 0.0502032283324047 0.200175531043098 EGFR/LRP1/ANXA1/LRP5/WLS/DPP4/DYNLL1/PPIA/GJA1/EXPH5/P3H1/SYT7/KCNN4/SLC16A1/TCF7L2/KIF5B/FRMD4A/MYH10/EFNA5/PPP3CA/REST/ISL1/RHBDF1 23 GO:0006766 vitamin metabolic process 11/1115 106/18722 0.0507995912333183 0.202402251936333 LRP2/SLC2A1/LGMN/SLC52A1/SLC19A1/SLC19A3/FOLR1/LMBRD1/TTPA/MTR/SLC52A2 11 GO:0046209 nitric oxide metabolic process 9/1115 81/18722 0.0511745647523465 0.203234336088687 ATP2B4/DYNLL1/P2RX4/HSP90AB1/CD47/GCHFR/CAV1/INSR/PKD2 9 GO:0031398 positive regulation of protein ubiquitination 12/1115 119/18722 0.051184649301193 0.203234336088687 NPM1/MYCBP2/RPS2/HSPA5/UBE2L3/SKP2/CAV1/XIAP/SKP1/UBE2C/CDC20/WFS1 12 GO:0016486 peptide hormone processing 4/1115 24/18722 0.0513129584280859 0.203234336088687 MME/ENPEP/FURIN/PCSK7 4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 4/1115 24/18722 0.0513129584280859 0.203234336088687 ATF6/HSPA5/RBPJ/CHD6 4 GO:0060149 negative regulation of posttranscriptional gene silencing 4/1115 24/18722 0.0513129584280859 0.203234336088687 NEAT1/KCNQ1OT1/NCOR1/PPP3CA 4 GO:0060967 negative regulation of gene silencing by RNA 4/1115 24/18722 0.0513129584280859 0.203234336088687 NEAT1/KCNQ1OT1/NCOR1/PPP3CA 4 GO:0061162 establishment of monopolar cell polarity 4/1115 24/18722 0.0513129584280859 0.203234336088687 FAT1/PRKCI/PTK7/RHOA 4 GO:1903077 negative regulation of protein localization to plasma membrane 4/1115 24/18722 0.0513129584280859 0.203234336088687 HECTD1/CLTC/LYPLA1/PPFIA1 4 GO:0006611 protein export from nucleus 7/1115 57/18722 0.0515257706896589 0.20347343913616 TPR/YWHAE/PTPN14/TCF7L2/AHCYL1/RAN/RANBP17 7 GO:0050891 multicellular organismal water homeostasis 7/1115 57/18722 0.0515257706896589 0.20347343913616 MET/PLEC/ATP6V1B1/TRPV4/CLDN4/ELOVL1/WFS1 7 GO:0060760 positive regulation of response to cytokine stimulus 7/1115 57/18722 0.0515257706896589 0.20347343913616 CD74/TRIM44/PARP14/ADAM17/AGPAT1/MAVS/HSPA1A 7 GO:1900024 regulation of substrate adhesion-dependent cell spreading 7/1115 57/18722 0.0515257706896589 0.20347343913616 KANK1/NRP1/FBLN1/ACTN4/P4HB/S100A10/EFNA5 7 GO:0045137 development of primary sexual characteristics 20/1115 227/18722 0.0517952299636285 0.204386350905996 LRP2/ADGRG1/ATRX/SF1/PRDX4/ADAMTS1/TGFBR1/HSPA5/KDM5A/NR2F2/RHOBTB3/ZFX/RAB13/CCND1/ARID5B/TLR3/IDH1/EIF2S2/SOD1/YBX3 20 GO:0006368 transcription elongation from RNA polymerase II promoter 8/1115 69/18722 0.0519005330184977 0.204650624657134 BRD4/TCERG1/ARID1A/SERTAD2/SETD2/CDK12/CDK13/CTNNB1 8 GO:0031345 negative regulation of cell projection organization 17/1115 186/18722 0.0522575674465164 0.205906385680407 LRP1/SEMA6D/KANK1/NRP1/SEMA6A/RTN4/SEMA3F/RYK/SEMA4B/THOC2/TRPV4/SEMA7A/TSKU/TRAK2/PPP3CA/RAPGEF2/RHOA 17 GO:0048704 embryonic skeletal system morphogenesis 10/1115 94/18722 0.0528735593168767 0.208179891735107 NIPBL/BMP7/DLG1/TGFBR1/CHST11/GLI3/SMAD2/SETD2/FGFR2/CTNNB1 10 GO:0048511 rhythmic process 25/1115 298/18722 0.0531747297239343 0.209211408987535 EGFR/LGR4/MYCBP2/SLC6A4/ADRB1/PRKDC/ZFHX3/SERPINF1/MAGED1/GNAQ/NCOR1/DDB1/USP9X/ADAMTS1/HSPA5/KDM5A/KLF10/SIAH2/NAGLU/CLDN4/NCOA2/KMT2A/OPN3/CREBBP/HNRNPD 25 GO:0046328 regulation of JNK cascade 13/1115 133/18722 0.0536947251272323 0.21094638517608 EGFR/IGF1R/APP/RB1CC1/NCOR1/TAOK1/GSTP1/TRPV4/TAOK3/HMGB1/TLR3/DNAJA1/LTBR 13 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 13/1115 133/18722 0.0536947251272323 0.21094638517608 CTSC/HECTD1/RNF217/ZYG11B/TMEM259/PIAS1/RNF19A/TMTC3/CAV1/DDA1/CSNK1A1/CDC20/HSPA1A 13 GO:0002790 peptide secretion 21/1115 242/18722 0.0538719321540784 0.211463421390583 EGFR/LRP1/ANXA1/LRP5/ABCA1/DPP4/CD74/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/TRPV4/SMAD2/EFNA5/PPP3CA/REST/ISL1 21 GO:0071901 negative regulation of protein serine/threonine kinase activity 12/1115 120/18722 0.0539349509864742 0.211463421390583 LRP5/NF1/BMP7/GSTP1/NR2F2/SMPD1/PKIB/LATS2/IPO7/CAV1/DNAJA1/CDKN1C 12 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 6/1115 46/18722 0.0539847618196974 0.211463421390583 EGFR/ANXA1/ADAMTS1/ADAM17/CCND1/ANKRD17 6 GO:1900271 regulation of long-term synaptic potentiation 6/1115 46/18722 0.0539847618196974 0.211463421390583 MME/LGMN/APP/PPP1R9A/NCSTN/PAIP2 6 GO:0045786 negative regulation of cell cycle 31/1115 385/18722 0.0544425656080799 0.213100335616964 EGFR/CDK6/NPM1/ZFP36L1/ATRX/PRKDC/BMP7/TPR/USP47/RPL26/TAOK1/DLG1/NR2F2/TP53I13/LATS2/TAOK3/JADE1/IPO7/PTPRK/MAPK14/CCND1/ZNF207/FEM1B/RNF167/PKD2/FZD3/FOXO4/ATM/CTNNB1/HPGD/CDKN1C 31 GO:2001057 reactive nitrogen species metabolic process 9/1115 82/18722 0.0545878702480113 0.213150533233112 ATP2B4/DYNLL1/P2RX4/HSP90AB1/CD47/GCHFR/CAV1/INSR/PKD2 9 GO:0021955 central nervous system neuron axonogenesis 5/1115 35/18722 0.05465500655481 0.213150533233112 MYCBP2/HSP90AB1/B4GALT5/NFIB/TSKU 5 GO:0043243 positive regulation of protein-containing complex disassembly 5/1115 35/18722 0.05465500655481 0.213150533233112 IGF1R/TRPV4/INSR/EIF5A/DSTN 5 GO:0045907 positive regulation of vasoconstriction 5/1115 35/18722 0.05465500655481 0.213150533233112 EGFR/GJA1/GJA5/CAV1/RHOA 5 GO:1905898 positive regulation of response to endoplasmic reticulum stress 5/1115 35/18722 0.05465500655481 0.213150533233112 ATF6/SERINC3/TMEM259/TMEM33/CAV1 5 GO:0042254 ribosome biogenesis 25/1115 299/18722 0.0548946407644322 0.213772784129324 RPL23A/RPL3/RPL6/RPLP0/RPL7/NPM1/RPS6/RPL5/RPS8/RPS16/RPL7A/RPL14/PRKDC/DDX17/RPS17/RPL26/RPL24/RPS21/RPS25/RPSA/RPL10A/RPL38/RPL35/RAN/RPL27 25 GO:1901990 regulation of mitotic cell cycle phase transition 25/1115 299/18722 0.0548946407644322 0.213772784129324 EGFR/ANXA1/PBX1/APP/ZFP36L1/BRD4/PRKDC/TPR/USP47/RPL26/TAOK1/DLG1/DDB1/ADAMTS1/ADAM17/TAOK3/JADE1/CCND1/ZNF207/APPL1/PKD2/ANKRD17/FOXO4/ATM/UBE2C 25 GO:0060041 retina development in camera-type eye 14/1115 147/18722 0.0556426770421835 0.214361126569149 ATP2B1/LRP5/NRP1/ATP2B4/COL4A1/SERPINF1/MAN2A1/RPL24/PTPRM/BMPR2/NAGLU/AHI1/OBSL1/ACVR2B 14 GO:1902652 secondary alcohol metabolic process 14/1115 147/18722 0.0556426770421835 0.214361126569149 LRP5/ABCA1/APP/VLDLR/NPC1/SMPD1/DHCR24/NFE2L1/TSKU/SREBF2/LPCAT3/IDH1/CAT/SOD1 14 GO:1902850 microtubule cytoskeleton organization involved in mitosis 14/1115 147/18722 0.0556426770421835 0.214361126569149 ITGB1/GJA1/TACC2/TPR/CLTC/DYNC1H1/KPNB1/SETD2/RAN/ZNF207/NUSAP1/CDC20/HSPA1A/RHOA 14 GO:0006826 iron ion transport 7/1115 58/18722 0.0557226158649964 0.214361126569149 FTH1/SLC40A1/CLTC/SLC11A2/TFRC/IREB2/FTL 7 GO:0010559 regulation of glycoprotein biosynthetic process 7/1115 58/18722 0.0557226158649964 0.214361126569149 ARFGEF1/ITM2B/TCF7L2/NCSTN/AGO2/ALG10B/CTNNB1 7 GO:0032481 positive regulation of type I interferon production 7/1115 58/18722 0.0557226158649964 0.214361126569149 GAPDH/TRIM56/DHX36/SETD2/HMGB1/TLR3/MAVS 7 GO:0097035 regulation of membrane lipid distribution 7/1115 58/18722 0.0557226158649964 0.214361126569149 ATP10D/ABCA1/ANO6/TMEM30A/KCNN4/TMEM30B/ATP11B 7 GO:0002070 epithelial cell maturation 3/1115 15/18722 0.0560265659852105 0.214361126569149 TFCP2L1/FEM1B/GPAT4 3 GO:0002730 regulation of dendritic cell cytokine production 3/1115 15/18722 0.0560265659852105 0.214361126569149 DHX36/TLR3/MAVS 3 GO:0010820 positive regulation of T cell chemotaxis 3/1115 15/18722 0.0560265659852105 0.214361126569149 ADAM10/ADAM17/WNK1 3 GO:0031958 corticosteroid receptor signaling pathway 3/1115 15/18722 0.0560265659852105 0.214361126569149 PTGES3/NR3C1/ARID1A 3 GO:0032488 Cdc42 protein signal transduction 3/1115 15/18722 0.0560265659852105 0.214361126569149 NRP1/ABCA1/RHOV 3 GO:0032933 SREBP signaling pathway 3/1115 15/18722 0.0560265659852105 0.214361126569149 AMFR/SREBF2/LPCAT3 3 GO:0035627 ceramide transport 3/1115 15/18722 0.0560265659852105 0.214361126569149 PSAP/SGPP1/PLEKHA8 3 GO:0042074 cell migration involved in gastrulation 3/1115 15/18722 0.0560265659852105 0.214361126569149 LRP5/AMOT/GPC3 3 GO:0045176 apical protein localization 3/1115 15/18722 0.0560265659852105 0.214361126569149 DLG5/ACTB/ARF4 3 GO:0045725 positive regulation of glycogen biosynthetic process 3/1115 15/18722 0.0560265659852105 0.214361126569149 EPM2AIP1/SORBS1/INSR 3 GO:0046184 aldehyde biosynthetic process 3/1115 15/18722 0.0560265659852105 0.214361126569149 TPI1/REST/TKT 3 GO:0050746 regulation of lipoprotein metabolic process 3/1115 15/18722 0.0560265659852105 0.214361126569149 ITGAV/RAB3GAP1/RAB3GAP2 3 GO:0051938 L-glutamate import 3/1115 15/18722 0.0560265659852105 0.214361126569149 ITGB1/ARL6IP5/SLC1A3 3 GO:0098712 L-glutamate import across plasma membrane 3/1115 15/18722 0.0560265659852105 0.214361126569149 ITGB1/ARL6IP5/SLC1A3 3 GO:0099170 postsynaptic modulation of chemical synaptic transmission 3/1115 15/18722 0.0560265659852105 0.214361126569149 CDH1/RNF19A/PPP3CA 3 GO:0150011 regulation of neuron projection arborization 3/1115 15/18722 0.0560265659852105 0.214361126569149 MACF1/DVL3/MOV10 3 GO:1990822 basic amino acid transmembrane transport 3/1115 15/18722 0.0560265659852105 0.214361126569149 SLC38A9/SLC7A6/SLC7A2 3 GO:0042982 amyloid precursor protein metabolic process 10/1115 95/18722 0.0560896223669417 0.214361126569149 RTN4/ADAM10/DLG1/ROCK1/ITM2B/NCSTN/ADAM17/DHCR24/CLN3/AGO2 10 GO:1901379 regulation of potassium ion transmembrane transport 10/1115 95/18722 0.0560896223669417 0.214361126569149 AKAP9/ITGB1/ANO6/ANK3/YWHAE/DLG1/KCNN4/WNK1/CAV1/ALG10B 10 GO:0043244 regulation of protein-containing complex disassembly 12/1115 121/18722 0.0567832702965651 0.216547057223829 IGF1R/SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/TRPV4/CLN3/CAMSAP2/INSR/EIF5A/DSTN 12 GO:0048706 embryonic skeletal system development 12/1115 121/18722 0.0567832702965651 0.216547057223829 PBX1/NIPBL/BMP7/DLG1/TGFBR1/KIAA1217/CHST11/GLI3/SMAD2/SETD2/FGFR2/CTNNB1 12 GO:1904019 epithelial cell apoptotic process 12/1115 121/18722 0.0567832702965651 0.216547057223829 KRT8/ZFP36L1/ANO6/KRT18/DNMT3A/TCF7L2/PRKCI/BMPR2/CFLAR/CAST/WFS1/PLA2R1 12 GO:0018105 peptidyl-serine phosphorylation 26/1115 315/18722 0.0579006206761424 0.220349249635609 EGFR/AKAP9/APP/ATP2B4/MIF/PRKDC/HSP90AB1/RPS6KA5/PKN2/SMG1/ROCK1/NSD1/TFRC/TGFBR1/RICTOR/PRKCI/GPD1L/DMD/LATS2/WNK1/AKT3/MAPK14/CAV1/CSNK1A1/MAST4/ATM 26 GO:0006091 generation of precursor metabolites and energy 38/1115 490/18722 0.0579479625559016 0.220349249635609 GAPDH/IL6ST/AGL/LDHA/GLDC/APP/GAA/ALDOA/ACSS1/ASPH/COX6A1/PLEC/PTGES3/PHKB/IL10RB/RB1CC1/NCOR1/ENO1/TPI1/IREB2/CHCHD2/CROT/DEGS1/EPM2AIP1/SORBS1/TRPV4/HMGB1/OPN3/ACOX1/INSR/ALDH4A1/DHRS3/IDH1/CAT/TKT/CYCS/RHOA/UQCRH 38 GO:0046785 microtubule polymerization 9/1115 83/18722 0.0581457591834604 0.220349249635609 AKAP9/MET/CLIP1/RPS3/TRPV4/CAMSAP2/ZNF207/OCLN/HSPA1A 9 GO:0010212 response to ionizing radiation 14/1115 148/18722 0.0582499810709161 0.220349249635609 ANXA1/NIPBL/PRKDC/DNMT3A/RPL26/NET1/HSPA5/SMPD1/MAPK14/CCND1/ITGB6/ATM/EEF1D/TRIM13 14 GO:0032331 negative regulation of chondrocyte differentiation 4/1115 25/18722 0.058316817706521 0.220349249635609 EFEMP1/LTBP3/TGFBR1/CTNNB1 4 GO:0048143 astrocyte activation 4/1115 25/18722 0.058316817706521 0.220349249635609 EGFR/LRP1/GRN/APP 4 GO:0061339 establishment or maintenance of monopolar cell polarity 4/1115 25/18722 0.058316817706521 0.220349249635609 FAT1/PRKCI/PTK7/RHOA 4 GO:0061436 establishment of skin barrier 4/1115 25/18722 0.058316817706521 0.220349249635609 MET/PLEC/CLDN4/ELOVL1 4 GO:0090169 regulation of spindle assembly 4/1115 25/18722 0.058316817706521 0.220349249635609 TPR/DYNC1H1/SENP6/HSPA1A 4 GO:0090382 phagosome maturation 4/1115 25/18722 0.058316817706521 0.220349249635609 SYT7/MYO7A/CLN3/RAB31 4 GO:0140448 signaling receptor ligand precursor processing 4/1115 25/18722 0.058316817706521 0.220349249635609 MME/ENPEP/FURIN/PCSK7 4 GO:1903792 negative regulation of anion transport 4/1115 25/18722 0.058316817706521 0.220349249635609 GABRE/SLC43A2/ARL6IP5/PLA2R1 4 GO:1903959 regulation of anion transmembrane transport 4/1115 25/18722 0.058316817706521 0.220349249635609 TCAF1/ITGB1/SLC43A2/ARL6IP5 4 GO:0007595 lactation 6/1115 47/18722 0.0589069281083167 0.221170245548736 PRLR/SLC29A1/DDR1/CAV1/CCND1/GPAT4 6 GO:0010761 fibroblast migration 6/1115 47/18722 0.0589069281083167 0.221170245548736 ITGB1/PLEC/GNA12/CLN3/APPL1/ARID5B 6 GO:0019884 antigen processing and presentation of exogenous antigen 6/1115 47/18722 0.0589069281083167 0.221170245548736 LGMN/CD74/CTSD/LNPEP/CTSF/MR1 6 GO:0042311 vasodilation 6/1115 47/18722 0.0589069281083167 0.221170245548736 EGFR/ADRB1/GJA1/GJA5/EDNRB/SOD1 6 GO:0045581 negative regulation of T cell differentiation 6/1115 47/18722 0.0589069281083167 0.221170245548736 ANXA1/CD74/GLI3/HMGB1/RC3H1/ERBB2 6 GO:0045646 regulation of erythrocyte differentiation 6/1115 47/18722 0.0589069281083167 0.221170245548736 CDK6/ZFP36L1/PRKDC/MAPK14/P4HTM/HSPA1A 6 GO:0046677 response to antibiotic 6/1115 47/18722 0.0589069281083167 0.221170245548736 RPL23/SLC9A1/HSPA5/AOC1/SLC1A3/SOD1 6 GO:0051972 regulation of telomerase activity 6/1115 47/18722 0.0589069281083167 0.221170245548736 PTGES3/HSP90AB1/PKIB/HNRNPA2B1/CTNNB1/HNRNPD 6 GO:0097300 programmed necrotic cell death 6/1115 47/18722 0.0589069281083167 0.221170245548736 ASAH1/TRPM7/CFLAR/CAV1/TLR3/YBX3 6 GO:0070371 ERK1 and ERK2 cascade 27/1115 330/18722 0.0590187740515773 0.221434458651701 EGFR/LRP1/ITGAV/NRP1/SEMA6A/FBLN1/APP/MIF/ZFP36L1/CD74/GCNT2/DLG1/FN1/GSTP1/ATP6AP1/TPBG/EIF3A/TRPV4/HMGB1/SEMA7A/ZDHHC17/PDGFD/CFLAR/GAREM1/FGFR2/ERBB2/RAPGEF2 27 GO:0042157 lipoprotein metabolic process 13/1115 135/18722 0.0591471103199025 0.221760127807556 LRP1/ITGAV/ABCA1/PGAP1/OLR1/CTSD/GPAA1/LYPLA1/ZDHHC20/RAB3GAP1/RAB3GAP2/ZDHHC17/ZDHHC21 13 GO:0003073 regulation of systemic arterial blood pressure 10/1115 96/18722 0.0594314994324343 0.222357936559052 MME/ADRB1/GJA1/ENPEP/GJA5/NR2F2/WNK1/BMPR2/NAV2/RHOA 10 GO:0015914 phospholipid transport 10/1115 96/18722 0.0594314994324343 0.222357936559052 ATP10D/ABCA1/ANO6/TMEM30A/SCARB2/KCNN4/PLEKHA8/OSBPL8/TMEM30B/ATP11B 10 GO:0035282 segmentation 10/1115 96/18722 0.0594314994324343 0.222357936559052 NRP2/NRP1/SEMA3F/PRKDC/FZD5/RBPJ/MIB1/COBL/BMPR1A/IRX2 10 GO:0032722 positive regulation of chemokine production 8/1115 71/18722 0.0596309909340192 0.222792064798271 LRP1/APP/CD74/ADAM17/TRPV4/HMGB1/TLR3/MAVS 8 GO:0033555 multicellular organismal response to stress 8/1115 71/18722 0.0596309909340192 0.222792064798271 ADRB1/DPP4/GJA1/P2RX4/VDAC1/VWA1/EDNRB/PPP3CA 8 GO:0043266 regulation of potassium ion transport 11/1115 109/18722 0.0598809477331219 0.22356949646653 AKAP9/ITGB1/ANO6/ANK3/YWHAE/DLG1/KCNN4/KIF5B/WNK1/CAV1/ALG10B 11 GO:0035306 positive regulation of dephosphorylation 7/1115 59/18722 0.0601258161911046 0.22417020436055 SLC39A10/PPIA/CALM1/HSP90AB1/SMPD1/PPP1R12A/PPP1R15B 7 GO:0071806 protein transmembrane transport 7/1115 59/18722 0.0601258161911046 0.22417020436055 ABCA1/SEC62/SEC63/SEC61A1/HSPA5/TRAM1/TRAM2 7 GO:0009410 response to xenobiotic stimulus 36/1115 462/18722 0.0601776063624677 0.2242067274035 EGFR/CDH1/ANXA1/LDHA/PLIN2/ABCA1/SLC6A4/RPN2/HSP90AB1/ADIRF/USP47/DNMT3A/GNA12/GSTP1/TFRC/HSPA5/SLC1A3/NPC1/SMPD1/DVL3/NCEH1/ADAM17/PPP1R12A/ATP1A1/PTPRM/S100A10/VAV3/ABCD3/MYO6/TLR3/REST/CAT/GGH/FZD3/RHOA/SOD1 36 GO:0030224 monocyte differentiation 5/1115 36/18722 0.0604919618197184 0.224907092030276 CDK6/ZFP36L1/CD74/FOXP1/FASN 5 GO:0060251 regulation of glial cell proliferation 5/1115 36/18722 0.0604919618197184 0.224907092030276 EGFR/DICER1/UFL1/PRKCI/PLAG1 5 GO:0090313 regulation of protein targeting to membrane 5/1115 36/18722 0.0604919618197184 0.224907092030276 TCAF1/ANK3/MYO1C/STOM/ERBB2 5 GO:0006405 RNA export from nucleus 9/1115 84/18722 0.0618495192110255 0.22947504035279 HNRNPA1/NPM1/TPR/SRSF3/SMG1/THOC2/SETD2/HNRNPA2B1/RAN 9 GO:0032370 positive regulation of lipid transport 9/1115 84/18722 0.0618495192110255 0.22947504035279 LRP1/ABCA1/TMEM30A/P2RX4/C1QTNF1/CAV1/LPCAT3/ANXA2/PLA2R1 9 GO:0097061 dendritic spine organization 9/1115 84/18722 0.0618495192110255 0.22947504035279 IGF1R/LGMN/CFL1/ADAM10/PPP1R9A/WASL/DHX36/INSR/ABI2 9 GO:0072331 signal transduction by p53 class mediator 15/1115 163/18722 0.0622628319994211 0.230848097253409 RPS20/RPL23/NPM1/RPL5/MIF/ATRX/CD74/RPL26/MDM4/RRM2B/MYO6/EIF5A/ATM/USP10/PLA2R1 15 GO:0010811 positive regulation of cell-substrate adhesion 12/1115 123/18722 0.0627779727512401 0.232435226434723 ITGA6/DAG1/UTRN/CDK6/IQGAP1/NRP1/CCDC80/FN1/ROCK1/P4HB/FERMT1/S100A10 12 GO:0030168 platelet activation 12/1115 123/18722 0.0627779727512401 0.232435226434723 IL6ST/ACTG1/PPIA/MYL12A/FN1/F11R/HSPB1/VAV3/C1QTNF1/FZD6/MAPK14/ACTB 12 GO:0003014 renal system process 11/1115 110/18722 0.06313074027642 0.233256070820627 LGMN/GJA1/ATP6V1B1/GJA5/CLDN4/CLN3/RRM2B/EDNRB/MAGED2/WFS1/RHOA 11 GO:0009408 response to heat 11/1115 110/18722 0.06313074027642 0.233256070820627 TPR/HSP90AB1/YWHAE/ATP2A2/TRPV4/DHX36/DNAJA1/CREBBP/ATM/HSPA1A/SOD1 11 GO:1905954 positive regulation of lipid localization 11/1115 110/18722 0.06313074027642 0.233256070820627 LRP1/PLIN2/ABCA1/TMEM30A/P2RX4/C1QTNF1/CAV1/SREBF2/LPCAT3/ANXA2/PLA2R1 11 GO:0071453 cellular response to oxygen levels 16/1115 177/18722 0.0632019706351807 0.233357760180657 MALAT1/ZFP36L1/BMP7/DNMT3A/MDM4/ENO1/SLC9A1/ATP6AP1/P4HB/NPEPPS/CHCHD2/CPEB4/RBPJ/SLC29A1/CFLAR/CAV1 16 GO:0043903 regulation of biological process involved in symbiotic interaction 8/1115 72/18722 0.0637535500331523 0.234906972827467 ITGAV/CD74/DDB1/P4HB/LY6E/CAV1/TRIM38/TRIM13 8 GO:0055021 regulation of cardiac muscle tissue growth 8/1115 72/18722 0.0637535500331523 0.234906972827467 GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 8 GO:0071479 cellular response to ionizing radiation 8/1115 72/18722 0.0637535500331523 0.234906972827467 NIPBL/RPL26/NET1/HSPA5/MAPK14/ITGB6/ATM/EEF1D 8 GO:0015804 neutral amino acid transport 6/1115 48/18722 0.0640879701586983 0.235651289722652 SLC38A2/SLC43A2/SLC1A5/SLC38A9/SERINC3/SLC38A1 6 GO:0042908 xenobiotic transport 6/1115 48/18722 0.0640879701586983 0.235651289722652 SLC2A1/GJA1/TMEM30A/SLC22A5/SLC22A18/ATP7B 6 GO:0061647 histone H3-K9 modification 6/1115 48/18722 0.0640879701586983 0.235651289722652 ASH1L/ATRX/RIF1/ZNF451/JARID2/KMT2A 6 GO:2001020 regulation of response to DNA damage stimulus 19/1115 219/18722 0.0643178328264354 0.235870410935721 EGFR/TPT1/NPM1/MIF/CD74/PRKDC/RPS3/USP47/UBR5/RPL26/SMG1/RIF1/TRIP12/SETD2/HMGB1/FEM1B/ATM/PLA2R1/FUS 19 GO:0031102 neuron projection regeneration 7/1115 60/18722 0.0647364853910503 0.235870410935721 LRP1/DAG1/GRN/PTPRF/FOLR1/MTR/ISL1 7 GO:0031638 zymogen activation 7/1115 60/18722 0.0647364853910503 0.235870410935721 LGMN/ASPH/FURIN/ENO1/DHCR24/PRSS12/CYFIP2 7 GO:0008203 cholesterol metabolic process 13/1115 137/18722 0.0649594892002294 0.235870410935721 LRP5/ABCA1/APP/VLDLR/NPC1/SMPD1/DHCR24/NFE2L1/TSKU/SREBF2/LPCAT3/CAT/SOD1 13 GO:0050714 positive regulation of protein secretion 13/1115 137/18722 0.0649594892002294 0.235870410935721 EGFR/LRP1/WLS/DYNLL1/PPIA/GJA1/EXPH5/KCNN4/TCF7L2/KIF5B/FRMD4A/MYH10/ISL1 13 GO:0055123 digestive system development 13/1115 137/18722 0.0649594892002294 0.235870410935721 EGFR/IL6ST/LGR4/WLS/NIPBL/SLC4A2/GLI3/SMAD2/COBL/AHI1/EDNRB/FGFR2/CTNNB1 13 GO:1901342 regulation of vasculature development 28/1115 348/18722 0.065365934306928 0.235870410935721 COL4A2/ITGB1/GRN/FLT1/NRP1/ITGB8/SEMA6A/ATP2B4/NF1/SERPINF1/ADAM10/ADAMTS1/GAB1/ROCK1/GTF2I/AMOT/PTPRM/HSPB1/EMC10/AGO2/AKT3/HMGB1/TLR3/ERAP1/ISL1/FOXO4/ERBB2/CTNNB1 28 GO:0007389 pattern specification process 34/1115 436/18722 0.0656509778196279 0.235870410935721 LRP2/ADGRG1/GALNT11/NRP2/LRP5/WLS/NRP1/PBX1/PGAP1/SEMA3F/PRKDC/BMP7/BPTF/FOLR1/TGFBR1/FZD5/MEIS2/NR2F2/RBPJ/GLI3/BMPR2/MIB1/SMAD2/COBL/AHI1/BMPR1A/PKD2/TRA2B/FGFR2/ISL1/GPC3/ACVR2B/CTNNB1/IRX2 34 GO:0055072 iron ion homeostasis 9/1115 85/18722 0.0657002281104125 0.235870410935721 FTH1/SLC40A1/SLC11A2/ATP6AP1/TFRC/IREB2/FBXL5/SOD1/FTL 9 GO:0071277 cellular response to calcium ion 9/1115 85/18722 0.0657002281104125 0.235870410935721 IQGAP1/LGMN/SYT7/HSPA5/SMPD1/NCSTN/WNK1/PKD2/FUS 9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 4/1115 26/18722 0.0658028186978419 0.235870410935721 SEC63/SEC61A1/TRAM1/TRAM2 4 GO:0014829 vascular associated smooth muscle contraction 4/1115 26/18722 0.0658028186978419 0.235870410935721 ATP2B1/ZDHHC21/EDNRB/RHOA 4 GO:0033522 histone H2A ubiquitination 4/1115 26/18722 0.0658028186978419 0.235870410935721 UBR5/DDB1/TRIP12/SKP1 4 GO:0034063 stress granule assembly 4/1115 26/18722 0.0658028186978419 0.235870410935721 PRRC2C/DYNC1H1/PUM2/C9orf72 4 GO:0046639 negative regulation of alpha-beta T cell differentiation 4/1115 26/18722 0.0658028186978419 0.235870410935721 ANXA1/GLI3/HMGB1/RC3H1 4 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 4/1115 26/18722 0.0658028186978419 0.235870410935721 SLC39A10/RPS3/KCNN4/FOXP1 4 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 4/1115 26/18722 0.0658028186978419 0.235870410935721 ADRB1/ATP2B4/AKAP13/RAPGEF2 4 GO:1904353 regulation of telomere capping 4/1115 26/18722 0.0658028186978419 0.235870410935721 TNKS2/PKIB/ATM/HNRNPD 4 GO:1904376 negative regulation of protein localization to cell periphery 4/1115 26/18722 0.0658028186978419 0.235870410935721 HECTD1/CLTC/LYPLA1/PPFIA1 4 GO:0001732 formation of cytoplasmic translation initiation complex 3/1115 16/18722 0.0660030706008554 0.235870410935721 EIF3A/EIF2S2/EIF3H 3 GO:0001845 phagolysosome assembly 3/1115 16/18722 0.0660030706008554 0.235870410935721 SYT7/MYO7A/CLN3 3 GO:0002371 dendritic cell cytokine production 3/1115 16/18722 0.0660030706008554 0.235870410935721 DHX36/TLR3/MAVS 3 GO:0003084 positive regulation of systemic arterial blood pressure 3/1115 16/18722 0.0660030706008554 0.235870410935721 NR2F2/WNK1/RHOA 3 GO:0007635 chemosensory behavior 3/1115 16/18722 0.0660030706008554 0.235870410935721 ATP6V1B1/TPBG/WFS1 3 GO:0010819 regulation of T cell chemotaxis 3/1115 16/18722 0.0660030706008554 0.235870410935721 ADAM10/ADAM17/WNK1 3 GO:0034138 toll-like receptor 3 signaling pathway 3/1115 16/18722 0.0660030706008554 0.235870410935721 COLEC12/CAV1/TLR3 3 GO:0048557 embryonic digestive tract morphogenesis 3/1115 16/18722 0.0660030706008554 0.235870410935721 NIPBL/GLI3/FGFR2 3 GO:0051014 actin filament severing 3/1115 16/18722 0.0660030706008554 0.235870410935721 CFL1/SCIN/DSTN 3 GO:0051238 sequestering of metal ion 3/1115 16/18722 0.0660030706008554 0.235870410935721 FTH1/SLC30A7/FTL 3 GO:0060572 morphogenesis of an epithelial bud 3/1115 16/18722 0.0660030706008554 0.235870410935721 BMP7/FGFR2/CTNNB1 3 GO:0061684 chaperone-mediated autophagy 3/1115 16/18722 0.0660030706008554 0.235870410935721 EEF1A1/LAMP2/CTSA 3 GO:0071361 cellular response to ethanol 3/1115 16/18722 0.0660030706008554 0.235870410935721 ITPR2/DNMT3A/ADCY7 3 GO:0071501 cellular response to sterol depletion 3/1115 16/18722 0.0660030706008554 0.235870410935721 AMFR/SREBF2/LPCAT3 3 GO:0071732 cellular response to nitric oxide 3/1115 16/18722 0.0660030706008554 0.235870410935721 MTR/CFLAR/HNRNPD 3 GO:0072109 glomerular mesangium development 3/1115 16/18722 0.0660030706008554 0.235870410935721 BMP7/PDGFD/CFLAR 3 GO:0097202 activation of cysteine-type endopeptidase activity 3/1115 16/18722 0.0660030706008554 0.235870410935721 LGMN/ASPH/CYFIP2 3 GO:0099010 modification of postsynaptic structure 3/1115 16/18722 0.0660030706008554 0.235870410935721 PFN1/MYH10/RHOA 3 GO:0099633 protein localization to postsynaptic specialization membrane 3/1115 16/18722 0.0660030706008554 0.235870410935721 DAG1/ADAM10/DLG1 3 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 3/1115 16/18722 0.0660030706008554 0.235870410935721 DAG1/ADAM10/DLG1 3 GO:1901163 regulation of trophoblast cell migration 3/1115 16/18722 0.0660030706008554 0.235870410935721 GJA1/AGO2/SMURF2 3 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/1115 16/18722 0.0660030706008554 0.235870410935721 MIF/CD74/RPL26 3 GO:2000765 regulation of cytoplasmic translation 3/1115 16/18722 0.0660030706008554 0.235870410935721 CPEB4/DHX36/YBX3 3 GO:0021537 telencephalon development 21/1115 248/18722 0.066261600080305 0.236635908246654 LRP1/ADGRG1/LAMB1/SLC2A1/CDK6/ATP2B4/RTN4/SLC38A2/NF1/TACC2/RYK/KIF5B/NFIB/GLI3/CELF1/SEMA7A/TSKU/TRA2B/UBA6/CTNNB1/RHOA 21 GO:0034655 nucleobase-containing compound catabolic process 32/1115 407/18722 0.0663845419687186 0.236916490354939 NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/PDE10A/PDE7A/TDG/RC3H1/ATM/MGAT1/HSPA1A/HNRNPD/SND1/FUS/YBX3 32 GO:0055067 monovalent inorganic cation homeostasis 14/1115 151/18722 0.0665646927548902 0.237242252749238 GRN/ATP6V1B1/SLC9A1/ATP6AP1/TMEM106B/SLC4A2/SLC1A3/CLN5/TTPA/CLCN3/ATP1A1/CLN3/EDNRB/ATP6V0A1 14 GO:1904064 positive regulation of cation transmembrane transport 14/1115 151/18722 0.0665646927548902 0.237242252749238 AKAP9/CALM1/ANO6/ANK3/SLC9A1/ACTN4/KCNN4/KIF5B/DMD/WNK1/TMSB4X/ALG10B/PKD2/VMP1 14 GO:0003161 cardiac conduction system development 5/1115 37/18722 0.0666684638240553 0.237295285571088 GJA1/DSG2/GJA5/BMPR1A/ISL1 5 GO:0006862 nucleotide transport 5/1115 37/18722 0.0666684638240553 0.237295285571088 SLC19A1/GJA1/CD47/SLC25A36/SLC29A1 5 GO:0018212 peptidyl-tyrosine modification 30/1115 378/18722 0.0669251609825213 0.238050256153019 EGFR/IL6ST/MET/CSH1/EFEMP1/IQGAP1/FLT1/NRP1/IGF1R/PRLR/APP/MIF/CD74/ERBB3/TPST2/RICTOR/EPHB4/PARP14/ADAM17/DDR1/PDGFD/CAV1/SUZ12/INSR/EFNA5/ABI2/IBTK/FGFR2/ISL1/ERBB2 30 GO:0071496 cellular response to external stimulus 26/1115 320/18722 0.0672037025446603 0.238881869431386 EGFR/DAG1/ATP2B1/HNRNPA1/SLC2A1/SLC38A2/GJA1/PLEC/TMEM150C/SLC9A1/FOLR1/GSTP1/MAP3K2/LAMP2/HSPA5/AOC1/KLF10/SKP2/CPEB4/ATP1A1/F11R/BMPR2/SREBF2/TLR3/ITFG2/LTBR 26 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 13/1115 138/18722 0.0680026219331125 0.241404476636 NPM1/MYCBP2/RPS2/HSPA5/UBE2L3/SKP2/PIAS1/CAV1/XIAP/SKP1/UBE2C/CDC20/WFS1 13 GO:0061035 regulation of cartilage development 8/1115 73/18722 0.0680490236630792 0.241404476636 EFEMP1/GLG1/SCIN/LTBP3/TGFBR1/GLI3/BMPR2/CTNNB1 8 GO:0072089 stem cell proliferation 8/1115 73/18722 0.0680490236630792 0.241404476636 N4BP2L2/RNF43/FBLN1/ZFP36L1/GJA1/ZNRF3/LTBP3/FERMT1 8 GO:0045926 negative regulation of growth 21/1115 249/18722 0.0685027760106031 0.242852802868931 SEMA6D/NRP1/SEMA6A/LGMN/SLC6A4/ADRB1/RTN4/SEMA3F/GJA1/SMARCA2/ENO1/RYK/SEMA4B/SERTAD2/JARID2/BMPR2/WWC2/JADE1/SEMA7A/GPC3/HSPA1A 21 GO:0016125 sterol metabolic process 14/1115 152/18722 0.0695028486629442 0.245301009204028 LRP5/ABCA1/APP/LIPA/VLDLR/NPC1/SMPD1/DHCR24/NFE2L1/TSKU/SREBF2/LPCAT3/CAT/SOD1 14 GO:0031056 regulation of histone modification 14/1115 152/18722 0.0695028486629442 0.245301009204028 NIPBL/ATRX/BRD4/UBR5/RPS6KA5/RIF1/ZNF451/NSD1/KDM5A/TRIP12/JARID2/KMT2A/ISL1/CTNNB1 14 GO:0014075 response to amine 6/1115 49/18722 0.069527992691604 0.245301009204028 GLDC/CALM1/RANBP2/RRM2B/PPP3CA/SOD1 6 GO:0051932 synaptic transmission, GABAergic 6/1115 49/18722 0.069527992691604 0.245301009204028 GABRE/KIF5B/TPBG/CLCN3/NISCH/CLN3 6 GO:0052372 modulation by symbiont of entry into host 6/1115 49/18722 0.069527992691604 0.245301009204028 ITGAV/CD74/P4HB/LY6E/CAV1/TRIM38 6 GO:0072091 regulation of stem cell proliferation 6/1115 49/18722 0.069527992691604 0.245301009204028 N4BP2L2/FBLN1/ZFP36L1/GJA1/LTBP3/FERMT1 6 GO:0072666 establishment of protein localization to vacuole 6/1115 49/18722 0.069527992691604 0.245301009204028 VPS13C/SCARB2/GCC2/GNPTAB/LAMP2/VPS13A 6 GO:0009798 axis specification 9/1115 86/18722 0.0696987508826578 0.245301009204028 WLS/PGAP1/FZD5/SMAD2/COBL/AHI1/BMPR1A/GPC3/CTNNB1 9 GO:0022406 membrane docking 9/1115 86/18722 0.0696987508826578 0.245301009204028 CALM1/USO1/ATP2A2/ROCK1/AHCYL1/CLN3/RAB13/ESYT2/VMP1 9 GO:2000117 negative regulation of cysteine-type endopeptidase activity 9/1115 86/18722 0.0696987508826578 0.245301009204028 USP47/IFI6/SIAH2/DHCR24/CAST/XIAP/SERPINB9/BIRC5/PRDX3 9 GO:2001251 negative regulation of chromosome organization 9/1115 86/18722 0.0696987508826578 0.245301009204028 HNRNPA1/ATRX/TPR/TNKS2/XRN1/DCP2/ZNF207/HNRNPC/ATM 9 GO:0000956 nuclear-transcribed mRNA catabolic process 11/1115 112/18722 0.0699699145274672 0.245931121568234 ZFP36L1/TNRC6B/SMG1/TTC37/CNOT6L/XRN1/DHX36/DCP2/AGO2/RC3H1/ATM 11 GO:0035601 protein deacylation 11/1115 112/18722 0.0699699145274672 0.245931121568234 NIPBL/TBL1X/MORF4L2/KDM5A/MIER1/LYPLA1/TBL1XR1/REST/ELK4/MORF4L1/RCOR3 11 GO:0033209 tumor necrosis factor-mediated signaling pathway 10/1115 99/18722 0.0702225255201994 0.2466566208897 KRT8/SPPL2A/KRT18/ACTN4/GSTP1/ADAM17/TMSB4X/SPPL2B/EIF5A/HSPA1A 10 GO:0043409 negative regulation of MAPK cascade 16/1115 180/18722 0.0711943036923839 0.249905580153608 DAG1/IGF1R/SEMA6A/FBLN1/ASH1L/NF1/PPIA/BMP7/NCOR1/DLG1/GSTP1/SMPD1/EIF3A/TAOK3/CAV1/DNAJA1 16 GO:1903201 regulation of oxidative stress-induced cell death 8/1115 74/18722 0.0725180564362889 0.254384956184853 MET/PPIA/P4HB/HSPB1/OXR1/REST/CTNNB1/SOD1 8 GO:0002478 antigen processing and presentation of exogenous peptide antigen 5/1115 38/18722 0.0731822365649024 0.256209810504927 LGMN/CD74/CTSD/LNPEP/CTSF 5 GO:0032373 positive regulation of sterol transport 5/1115 38/18722 0.0731822365649024 0.256209810504927 LRP1/ABCA1/CAV1/LPCAT3/ANXA2 5 GO:0032376 positive regulation of cholesterol transport 5/1115 38/18722 0.0731822365649024 0.256209810504927 LRP1/ABCA1/CAV1/LPCAT3/ANXA2 5 GO:0031623 receptor internalization 11/1115 113/18722 0.0735607362735973 0.256893242220623 LRP1/ITGB1/CLTC/LMBRD1/TFRC/SCYL2/AHI1/CAV1/RAB31/INSR/MKLN1 11 GO:0003171 atrioventricular valve development 4/1115 27/18722 0.073762378783333 0.256893242220623 MDM4/GJA5/BMPR2/BMPR1A 4 GO:0003272 endocardial cushion formation 4/1115 27/18722 0.073762378783333 0.256893242220623 BMP7/TGFBR1/RBPJ/BMPR1A 4 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 4/1115 27/18722 0.073762378783333 0.256893242220623 CALM1/SLC9A1/ATP2A2/DMD 4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 4/1115 27/18722 0.073762378783333 0.256893242220623 PBX1/APP/BRD4/CCND1 4 GO:0033561 regulation of water loss via skin 4/1115 27/18722 0.073762378783333 0.256893242220623 MET/PLEC/CLDN4/ELOVL1 4 GO:0034453 microtubule anchoring 4/1115 27/18722 0.073762378783333 0.256893242220623 DAG1/CEP350/GCC2/PCM1 4 GO:0070861 regulation of protein exit from endoplasmic reticulum 4/1115 27/18722 0.073762378783333 0.256893242220623 TMEM30A/ERLEC1/GCC2/TMEM30B 4 GO:0044070 regulation of anion transport 9/1115 87/18722 0.0738457375262245 0.257015901338013 TCAF1/ITGB1/GABRE/SLC43A2/ARL6IP5/P2RX4/AHCYL1/RAB3GAP1/PLA2R1 9 GO:0061640 cytoskeleton-dependent cytokinesis 10/1115 100/18722 0.0740773854879201 0.257654176625411 SON/ANK3/PLEC/SPTBN1/RASA1/SNX18/ROCK1/MYH10/NUSAP1/RHOA 10 GO:0030073 insulin secretion 17/1115 195/18722 0.0742473167291244 0.258065922375687 LRP1/ANXA1/LRP5/DPP4/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/SMAD2/EFNA5/PPP3CA/REST/ISL1 17 GO:0070372 regulation of ERK1 and ERK2 cascade 25/1115 309/18722 0.0743222009018787 0.258065922375687 EGFR/LRP1/NRP1/SEMA6A/FBLN1/APP/MIF/CD74/GCNT2/DLG1/FN1/GSTP1/ATP6AP1/TPBG/EIF3A/TRPV4/HMGB1/SEMA7A/ZDHHC17/PDGFD/CFLAR/GAREM1/FGFR2/ERBB2/RAPGEF2 25 GO:0031333 negative regulation of protein-containing complex assembly 13/1115 140/18722 0.0743660077354477 0.258065922375687 RPL13A/KANK1/PFN1/SCIN/SPTBN1/ADD3/ARFGEF1/SPTAN1/HSPA5/KANK4/TMSB4X/HMGB1/ISL1 13 GO:0009311 oligosaccharide metabolic process 7/1115 62/18722 0.0745824533106733 0.258065922375687 GAA/HEXB/MANBA/B4GALT1/MOGS/GM2A/MAN1B1 7 GO:0046847 filopodium assembly 7/1115 62/18722 0.0745824533106733 0.258065922375687 ITGB4/NRP1/TGFBR1/PPP1R9A/WASL/CLN3/S1PR2 7 GO:0060135 maternal process involved in female pregnancy 7/1115 62/18722 0.0745824533106733 0.258065922375687 ASH1L/GJA1/CTSB/ADCY7/NR2F2/BMPR2/PRDX3 7 GO:0070265 necrotic cell death 7/1115 62/18722 0.0745824533106733 0.258065922375687 ASAH1/TRPM7/CFLAR/CAV1/TLR3/TMEM123/YBX3 7 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 7/1115 62/18722 0.0745824533106733 0.258065922375687 DAG1/CTNND1/ADAM10/YWHAE/DLG1/CLSTN1/PRKCI 7 GO:1903747 regulation of establishment of protein localization to mitochondrion 6/1115 50/18722 0.0752263992784477 0.260125482997171 LMAN1/FZD5/UBE2L3/NPEPPS/SREBF2/DNAJA1 6 GO:0035270 endocrine system development 12/1115 127/18722 0.0759825919213881 0.261420205320321 CDH1/ANXA1/CDK6/PBX1/NF1/TGFBR1/RBPJ/SMAD2/LY6E/ARID5B/BMPR1A/ISL1 12 GO:0048565 digestive tract development 12/1115 127/18722 0.0759825919213881 0.261420205320321 EGFR/IL6ST/LGR4/NIPBL/SLC4A2/GLI3/SMAD2/COBL/AHI1/EDNRB/FGFR2/CTNNB1 12 GO:0006895 Golgi to endosome transport 3/1115 17/18722 0.0767270016364379 0.261420205320321 VPS13C/VPS13A/MON2 3 GO:0008334 histone mRNA metabolic process 3/1115 17/18722 0.0767270016364379 0.261420205320321 XRN1/DCP2/ATM 3 GO:0010715 regulation of extracellular matrix disassembly 3/1115 17/18722 0.0767270016364379 0.261420205320321 LRP1/DPP4/DDR1 3 GO:0016264 gap junction assembly 3/1115 17/18722 0.0767270016364379 0.261420205320321 GJA1/GJA5/CAV1 3 GO:0031445 regulation of heterochromatin assembly 3/1115 17/18722 0.0767270016364379 0.261420205320321 TPR/MPHOSPH8/ATF7IP 3 GO:0035729 cellular response to hepatocyte growth factor stimulus 3/1115 17/18722 0.0767270016364379 0.261420205320321 NRP1/LGMN/APPL1 3 GO:0038065 collagen-activated signaling pathway 3/1115 17/18722 0.0767270016364379 0.261420205320321 COL4A2/COL4A1/DDR1 3 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 3/1115 17/18722 0.0767270016364379 0.261420205320321 PARP14/CAV1/SUZ12 3 GO:0044539 long-chain fatty acid import into cell 3/1115 17/18722 0.0767270016364379 0.261420205320321 SLC2A1/SLC27A2/ACSL3 3 GO:0045198 establishment of epithelial cell apical/basal polarity 3/1115 17/18722 0.0767270016364379 0.261420205320321 FAT1/PTK7/RHOA 3 GO:0046827 positive regulation of protein export from nucleus 3/1115 17/18722 0.0767270016364379 0.261420205320321 TPR/YWHAE/TCF7L2 3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 3/1115 17/18722 0.0767270016364379 0.261420205320321 ATP2A2/SYT7/RAB3GAP1 3 GO:0055119 relaxation of cardiac muscle 3/1115 17/18722 0.0767270016364379 0.261420205320321 P2RX4/ATP2A2/ATP1A1 3 GO:0060033 anatomical structure regression 3/1115 17/18722 0.0767270016364379 0.261420205320321 LRP5/FLT1/BMPR1A 3 GO:0070206 protein trimerization 3/1115 17/18722 0.0767270016364379 0.261420205320321 MIF/CD74/SLC1A5 3 GO:0090399 replicative senescence 3/1115 17/18722 0.0767270016364379 0.261420205320321 MME/ATM/PLA2R1 3 GO:0120261 regulation of heterochromatin organization 3/1115 17/18722 0.0767270016364379 0.261420205320321 TPR/MPHOSPH8/ATF7IP 3 GO:0140354 lipid import into cell 3/1115 17/18722 0.0767270016364379 0.261420205320321 SLC2A1/SLC27A2/ACSL3 3 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 3/1115 17/18722 0.0767270016364379 0.261420205320321 NFIB/NFATC3/REST 3 GO:1903830 magnesium ion transmembrane transport 3/1115 17/18722 0.0767270016364379 0.261420205320321 TUSC3/ZDHHC17/CNNM2 3 GO:1904355 positive regulation of telomere capping 3/1115 17/18722 0.0767270016364379 0.261420205320321 TNKS2/PKIB/HNRNPD 3 GO:1902369 negative regulation of RNA catabolic process 8/1115 75/18722 0.077160990804618 0.262731205297102 YBX1/LRPPRC/DHX36/MAPK14/HNRNPC/HNRNPD/FUS/YBX3 8 GO:0016571 histone methylation 13/1115 141/18722 0.0776873216095536 0.263952185255626 ASH1L/ATRX/BRD4/KMT2C/TET2/RIF1/NSD1/JARID2/SETD2/KMT2A/SUZ12/CREBBP/CTNNB1 13 GO:0035296 regulation of tube diameter 13/1115 141/18722 0.0776873216095536 0.263952185255626 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/ROCK1/GJA5/BMPR2/CAV1/ZDHHC21/EDNRB/RHOA/SOD1 13 GO:0097746 blood vessel diameter maintenance 13/1115 141/18722 0.0776873216095536 0.263952185255626 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/ROCK1/GJA5/BMPR2/CAV1/ZDHHC21/EDNRB/RHOA/SOD1 13 GO:0050900 leukocyte migration 29/1115 369/18722 0.0777173319389106 0.263952185255626 CSF3R/ITGB1/ANXA1/FLT1/LGMN/APP/MIF/DPP4/CD74/PPIA/ANO6/PLEC/DOCK8/P2RX4/ADAM10/B4GALT1/ROCK1/CD47/ADAM17/WNK1/TRPV4/F11R/MIA3/WASL/VAV3/HMGB1/PDGFD/EDNRB/RHOA 29 GO:0009743 response to carbohydrate 21/1115 253/18722 0.0779850775419195 0.264693152572351 LRP1/COLEC12/LRP5/IGF1R/LDHA/ZFP36L1/DYNLL1/GJA1/SERPINF1/KRT18/GSTP1/CCDC186/TCF7L2/KIF5B/SLC29A1/SMAD2/EFNA5/PPP3CA/TRA2B/CAT/RHOA 21 GO:0006476 protein deacetylation 10/1115 101/18722 0.0780621312898587 0.264786352577227 NIPBL/TBL1X/MORF4L2/KDM5A/MIER1/TBL1XR1/REST/ELK4/MORF4L1/RCOR3 10 GO:0031110 regulation of microtubule polymerization or depolymerization 9/1115 88/18722 0.0781416214876908 0.26488769341129 AKAP9/MET/CLIP1/RPS3/TAOK1/TRPV4/CAMSAP2/OCLN/HSPA1A 9 GO:0042692 muscle cell differentiation 30/1115 384/18722 0.0782862835725705 0.265209687813423 KRT19/ITGB1/KRT8/ACTG1/PLD3/YBX1/PLEC/MORF4L2/SLC9A1/ATP2A2/ACTN4/AKAP13/DMD/RBPJ/BMPR2/PIAS1/MAPK14/CFLAR/NFATC3/EDNRB/MYOF/BMPR1A/OBSL1/PPP3CA/ERVW-1/FGFR2/ISL1/ANKRD17/FOXO4/CTNNB1 30 GO:0072593 reactive oxygen species metabolic process 20/1115 239/18722 0.0786798330544431 0.266373892630103 EGFR/PRDX1/SLC5A3/BMP7/PRDX4/GPX3/GSTP1/IFI6/VDAC1/CLCN3/MAPK14/CFLAR/SH3PXD2A/ACOX1/CAT/PLA2R1/ARF4/PRDX3/RHOA/SOD1 20 GO:0034284 response to monosaccharide 19/1115 225/18722 0.0792444368303809 0.268115366436884 LRP1/LRP5/IGF1R/LDHA/DYNLL1/GJA1/SERPINF1/KRT18/GSTP1/CCDC186/TCF7L2/KIF5B/SLC29A1/SMAD2/EFNA5/PPP3CA/TRA2B/CAT/RHOA 19 GO:0050807 regulation of synapse organization 18/1115 211/18722 0.0796499102883756 0.269316574432956 DAG1/NRP2/APP/CFL1/SEMA3F/CDKL5/ADAM10/DLG5/CLSTN1/PPP1R9A/TPBG/DHX36/CLN3/MAPK14/ABI2/CDC20/ARF4/RHOA 18 GO:0022617 extracellular matrix disassembly 7/1115 63/18722 0.0798177534215774 0.269542685337003 LAMC1/LRP1/DPP4/FURIN/ADAM10/MMP15/DDR1 7 GO:0032233 positive regulation of actin filament bundle assembly 7/1115 63/18722 0.0798177534215774 0.269542685337003 PFN1/NRP1/CD47/TGFBR1/MTSS1/S100A10/RHOA 7 GO:0016233 telomere capping 5/1115 39/18722 0.080029831237933 0.269917415653395 PRKDC/TNKS2/PKIB/ATM/HNRNPD 5 GO:0090224 regulation of spindle organization 5/1115 39/18722 0.080029831237933 0.269917415653395 TPR/CLTC/DYNC1H1/SENP6/HSPA1A 5 GO:0042471 ear morphogenesis 11/1115 115/18722 0.0810875242211627 0.272084244236104 NIPBL/ATP6V1B1/RPL38/MYO7A/NAGLU/FZD6/MYO6/FGFR2/FZD3/PTK7/SOD1 11 GO:1901989 positive regulation of cell cycle phase transition 11/1115 115/18722 0.0810875242211627 0.272084244236104 EGFR/ANXA1/PBX1/NPM1/APP/BRD4/ADAMTS1/ADAM17/CCND1/ANKRD17/UBE2C 11 GO:0035150 regulation of tube size 13/1115 142/18722 0.0811022910452718 0.272084244236104 EGFR/ATP2B1/SLC6A4/ADRB1/GJA1/ROCK1/GJA5/BMPR2/CAV1/ZDHHC21/EDNRB/RHOA/SOD1 13 GO:0046467 membrane lipid biosynthetic process 13/1115 142/18722 0.0811022910452718 0.272084244236104 HACD3/ASAH1/PLPP3/PGAP1/ORMDL1/SGPP1/B4GALT5/GPAA1/B3GNT5/SMPD1/DEGS1/SPTLC3/ELOVL1 13 GO:2000045 regulation of G1/S transition of mitotic cell cycle 13/1115 142/18722 0.0811022910452718 0.272084244236104 EGFR/ANXA1/PRKDC/RPL26/DLG1/ADAMTS1/ADAM17/JADE1/CCND1/APPL1/PKD2/ANKRD17/ATM 13 GO:0006636 unsaturated fatty acid biosynthetic process 6/1115 51/18722 0.0811819069241643 0.272084244236104 ANXA1/MIF/CD74/PTGES3/DEGS1/ELOVL1 6 GO:0032873 negative regulation of stress-activated MAPK cascade 6/1115 51/18722 0.0811819069241643 0.272084244236104 PPIA/NCOR1/DLG1/GSTP1/TAOK3/DNAJA1 6 GO:0051293 establishment of spindle localization 6/1115 51/18722 0.0811819069241643 0.272084244236104 ITGB1/CFL1/GJA1/DYNC1H1/KPNB1/NUSAP1 6 GO:0065002 intracellular protein transmembrane transport 6/1115 51/18722 0.0811819069241643 0.272084244236104 SEC62/SEC63/SEC61A1/HSPA5/TRAM1/TRAM2 6 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 6/1115 51/18722 0.0811819069241643 0.272084244236104 PPIA/NCOR1/DLG1/GSTP1/TAOK3/DNAJA1 6 GO:0032886 regulation of microtubule-based process 20/1115 240/18722 0.0812749021331664 0.272225032929094 AKAP9/MET/NPM1/CLIP1/MACF1/RPS3/TPR/KLHL42/CLTC/TAOK1/ROCK1/DYNC1H1/TRPV4/SENP6/CAMSAP2/EFNA5/OCLN/ERBB2/HSPA1A/RHOA 20 GO:0008652 cellular amino acid biosynthetic process 8/1115 76/18722 0.0819778673259456 0.272367672020416 ATP2B4/BCAT1/SERINC3/SLC1A3/MTR/CLN3/ALDH18A1/BCAT2 8 GO:0043536 positive regulation of blood vessel endothelial cell migration 8/1115 76/18722 0.0819778673259456 0.272367672020416 ANXA1/NRP1/P2RX4/ADAM17/TMSB4X/HSPB1/AKT3/HMGB1 8 GO:0071426 ribonucleoprotein complex export from nucleus 8/1115 76/18722 0.0819778673259456 0.272367672020416 NPM1/TPR/SRSF3/SMG1/THOC2/SETD2/HNRNPA2B1/RAN 8 GO:1902106 negative regulation of leukocyte differentiation 10/1115 102/18722 0.082177095900958 0.272367672020416 FBN1/ANXA1/CDK6/CD74/GLI3/HMGB1/TLR3/RC3H1/ERBB2/CTNNB1 10 GO:1902749 regulation of cell cycle G2/M phase transition 10/1115 102/18722 0.082177095900958 0.272367672020416 PBX1/NPM1/APP/BRD4/USP47/TAOK1/TAOK3/CCND1/FOXO4/ATM 10 GO:0000470 maturation of LSU-rRNA 4/1115 28/18722 0.0821847386448567 0.272367672020416 RPL7/RPL7A/RPL10A/RPL35 4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 4/1115 28/18722 0.0821847386448567 0.272367672020416 LNPEP/ERAP1/TAPBP/MR1 4 GO:0006972 hyperosmotic response 4/1115 28/18722 0.0821847386448567 0.272367672020416 SLC2A1/TRPV4/TLR3/YBX3 4 GO:0007064 mitotic sister chromatid cohesion 4/1115 28/18722 0.0821847386448567 0.272367672020416 NIPBL/ATRX/PDS5B/CDC20 4 GO:0010818 T cell chemotaxis 4/1115 28/18722 0.0821847386448567 0.272367672020416 PLEC/ADAM10/ADAM17/WNK1 4 GO:0034123 positive regulation of toll-like receptor signaling pathway 4/1115 28/18722 0.0821847386448567 0.272367672020416 RTN4/HMGB1/CAV1/TLR3 4 GO:0051503 adenine nucleotide transport 4/1115 28/18722 0.0821847386448567 0.272367672020416 SLC19A1/GJA1/CD47/SLC29A1 4 GO:0051894 positive regulation of focal adhesion assembly 4/1115 28/18722 0.0821847386448567 0.272367672020416 IQGAP1/NRP1/ROCK1/S100A10 4 GO:0060325 face morphogenesis 4/1115 28/18722 0.0821847386448567 0.272367672020416 NIPBL/ANKRD11/RAB3GAP1/ARID5B 4 GO:0061082 myeloid leukocyte cytokine production 4/1115 28/18722 0.0821847386448567 0.272367672020416 CD74/DHX36/SEMA7A/MAVS 4 GO:1903779 regulation of cardiac conduction 4/1115 28/18722 0.0821847386448567 0.272367672020416 ATP2B1/ATP2B4/ATP2A2/GJA5 4 GO:1990776 response to angiotensin 4/1115 28/18722 0.0821847386448567 0.272367672020416 IQGAP1/ROCK1/AHCYL1/CAV1 4 GO:0006469 negative regulation of protein kinase activity 18/1115 212/18722 0.0824479513478638 0.273070479060946 LRP5/NPM1/NF1/PPIA/PLEC/BMP7/GNAQ/GSTP1/NR2F2/SMPD1/PKIB/LATS2/HSPB1/IPO7/CAV1/IBTK/DNAJA1/CDKN1C 18 GO:1900407 regulation of cellular response to oxidative stress 9/1115 89/18722 0.082586618776745 0.273360172132078 MET/PPIA/BMP7/P4HB/HSPB1/OXR1/REST/CTNNB1/SOD1 9 GO:0045765 regulation of angiogenesis 27/1115 342/18722 0.0827122151947389 0.273606268230924 COL4A2/ITGB1/GRN/FLT1/NRP1/ITGB8/SEMA6A/ATP2B4/NF1/SERPINF1/ADAMTS1/GAB1/ROCK1/GTF2I/AMOT/PTPRM/HSPB1/EMC10/AGO2/AKT3/HMGB1/TLR3/ERAP1/ISL1/FOXO4/ERBB2/CTNNB1 27 GO:0098732 macromolecule deacylation 11/1115 116/18722 0.0850241845197438 0.281079951177035 NIPBL/TBL1X/MORF4L2/KDM5A/MIER1/LYPLA1/TBL1XR1/REST/ELK4/MORF4L1/RCOR3 11 GO:0030888 regulation of B cell proliferation 7/1115 64/18722 0.0852605333899746 0.281512670234431 SLC39A10/MIF/CD74/TFRC/VAV3/RC3H1/ATM 7 GO:1903018 regulation of glycoprotein metabolic process 7/1115 64/18722 0.0852605333899746 0.281512670234431 ARFGEF1/ITM2B/TCF7L2/NCSTN/AGO2/ALG10B/CTNNB1 7 GO:1990845 adaptive thermogenesis 14/1115 157/18722 0.085467300481481 0.282020962466395 LGR4/IGF1R/PRLR/ADRB1/GJA1/ESRRG/LNPEP/DYNC1H1/RBPJ/ADAM17/TRPV4/CPT2/CAV1/ACVR2B 14 GO:0009135 purine nucleoside diphosphate metabolic process 10/1115 103/18722 0.086422448756985 0.284644943808478 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/DLG1/TPI1/AK3/INSR 10 GO:0009179 purine ribonucleoside diphosphate metabolic process 10/1115 103/18722 0.086422448756985 0.284644943808478 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/DLG1/TPI1/AK3/INSR 10 GO:0030148 sphingolipid biosynthetic process 10/1115 103/18722 0.086422448756985 0.284644943808478 HACD3/ASAH1/PLPP3/ORMDL1/SGPP1/B4GALT5/SMPD1/DEGS1/SPTLC3/ELOVL1 10 GO:0042476 odontogenesis 12/1115 130/18722 0.0869676792516925 0.285817356738394 CSF3R/LAMA5/LAMB1/BMP7/ANKRD11/SLC4A2/GLI3/BMPR1A/ITGB6/FGFR2/CTNNB1/RHOA 12 GO:0071166 ribonucleoprotein complex localization 8/1115 77/18722 0.0869684259688022 0.285817356738394 NPM1/TPR/SRSF3/SMG1/THOC2/SETD2/HNRNPA2B1/RAN 8 GO:0140056 organelle localization by membrane tethering 8/1115 77/18722 0.0869684259688022 0.285817356738394 CALM1/USO1/ATP2A2/AHCYL1/CLN3/RAB13/ESYT2/VMP1 8 GO:0042475 odontogenesis of dentin-containing tooth 9/1115 90/18722 0.0871807277326383 0.285817356738394 CSF3R/LAMA5/BMP7/ANKRD11/SLC4A2/GLI3/BMPR1A/ITGB6/CTNNB1 9 GO:0046031 ADP metabolic process 9/1115 90/18722 0.0871807277326383 0.285817356738394 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/AK3/INSR 9 GO:0099175 regulation of postsynapse organization 9/1115 90/18722 0.0871807277326383 0.285817356738394 NRP2/CFL1/SEMA3F/CDKL5/ADAM10/PPP1R9A/DHX36/ABI2/ARF4 9 GO:0045777 positive regulation of blood pressure 5/1115 40/18722 0.0872066817993713 0.285817356738394 ADRB1/NR2F2/WNK1/F11R/RHOA 5 GO:0070266 necroptotic process 5/1115 40/18722 0.0872066817993713 0.285817356738394 TRPM7/CFLAR/CAV1/TLR3/YBX3 5 GO:0016570 histone modification 35/1115 463/18722 0.0875356883807476 0.285960458018336 NIPBL/ASH1L/ATRX/BRD4/NCOA3/TBL1X/MORF4L2/KMT2C/UBR5/RPS6KA5/TET2/RIF1/DDB1/ZNF451/UFL1/NSD1/JMJD1C/KDM5A/MIER1/TRIP12/JARID2/TBL1XR1/JADE1/SETD2/KMT2A/SUZ12/SKP1/REST/ISL1/CREBBP/ATM/CTNNB1/ELK4/MORF4L1/RCOR3 35 GO:0001946 lymphangiogenesis 3/1115 18/18722 0.088158255376269 0.285960458018336 PTPN14/BMPR2/ACVR2B 3 GO:0003128 heart field specification 3/1115 18/18722 0.088158255376269 0.285960458018336 LRP2/RBPJ/ISL1 3 GO:0006991 response to sterol depletion 3/1115 18/18722 0.088158255376269 0.285960458018336 AMFR/SREBF2/LPCAT3 3 GO:0015693 magnesium ion transport 3/1115 18/18722 0.088158255376269 0.285960458018336 TUSC3/ZDHHC17/CNNM2 3 GO:0030206 chondroitin sulfate biosynthetic process 3/1115 18/18722 0.088158255376269 0.285960458018336 CHPF/DSE/CHST11 3 GO:0036499 PERK-mediated unfolded protein response 3/1115 18/18722 0.088158255376269 0.285960458018336 HSPA5/TMEM33/PPP1R15B 3 GO:0043217 myelin maintenance 3/1115 18/18722 0.088158255376269 0.285960458018336 PLEC/DEGS1/SOD1 3 GO:0055070 copper ion homeostasis 3/1115 18/18722 0.088158255376269 0.285960458018336 APP/XIAP/ATP7B 3 GO:0060391 positive regulation of SMAD protein signal transduction 3/1115 18/18722 0.088158255376269 0.285960458018336 TGFBR1/BMPR2/BMPR1A 3 GO:0061484 hematopoietic stem cell homeostasis 3/1115 18/18722 0.088158255376269 0.285960458018336 ADGRG1/FSTL1/OCIAD2 3 GO:0071318 cellular response to ATP 3/1115 18/18722 0.088158255376269 0.285960458018336 HSP90B1/P2RX4/SOD1 3 GO:1902001 fatty acid transmembrane transport 3/1115 18/18722 0.088158255376269 0.285960458018336 SLC2A1/CPT2/ABCD3 3 GO:1902074 response to salt 3/1115 18/18722 0.088158255376269 0.285960458018336 HNRNPA1/HSPA5/HNRNPD 3 GO:1902170 cellular response to reactive nitrogen species 3/1115 18/18722 0.088158255376269 0.285960458018336 MTR/CFLAR/HNRNPD 3 GO:0014065 phosphatidylinositol 3-kinase signaling 13/1115 144/18722 0.0882144361034274 0.285960458018336 EGFR/FLT1/IGF1R/ZFP36L1/PLXNB1/NF1/ERBB3/FN1/PDGFD/PIK3IP1/INSR/CAT/ERBB2 13 GO:0106106 cold-induced thermogenesis 13/1115 144/18722 0.0882144361034274 0.285960458018336 LGR4/IGF1R/PRLR/ADRB1/GJA1/ESRRG/LNPEP/DYNC1H1/RBPJ/ADAM17/CPT2/CAV1/ACVR2B 13 GO:0120161 regulation of cold-induced thermogenesis 13/1115 144/18722 0.0882144361034274 0.285960458018336 LGR4/IGF1R/PRLR/ADRB1/GJA1/ESRRG/LNPEP/DYNC1H1/RBPJ/ADAM17/CPT2/CAV1/ACVR2B 13 GO:0018108 peptidyl-tyrosine phosphorylation 29/1115 375/18722 0.0905457174706141 0.291110311603925 EGFR/IL6ST/MET/CSH1/EFEMP1/IQGAP1/FLT1/NRP1/IGF1R/PRLR/APP/MIF/CD74/ERBB3/RICTOR/EPHB4/PARP14/ADAM17/DDR1/PDGFD/CAV1/SUZ12/INSR/EFNA5/ABI2/IBTK/FGFR2/ISL1/ERBB2 29 GO:0018022 peptidyl-lysine methylation 12/1115 131/18722 0.0908371831082382 0.291110311603925 ASH1L/ATRX/BRD4/KMT2C/TET2/RIF1/NSD1/JARID2/SETD2/KMT2A/SUZ12/CTNNB1 12 GO:0046683 response to organophosphorus 12/1115 131/18722 0.0908371831082382 0.291110311603925 AKAP9/LDHA/HSP90B1/SLC6A4/APP/ZFP36L1/P2RX4/ITPR2/HSPA5/PKD2/RAPGEF2/SOD1 12 GO:0043489 RNA stabilization 7/1115 65/18722 0.0909097052904476 0.291110311603925 YBX1/DHX36/MAPK14/HNRNPC/HNRNPD/FUS/YBX3 7 GO:0046513 ceramide biosynthetic process 7/1115 65/18722 0.0909097052904476 0.291110311603925 ASAH1/ORMDL1/B4GALT5/SMPD1/DEGS1/SPTLC3/ELOVL1 7 GO:1905330 regulation of morphogenesis of an epithelium 7/1115 65/18722 0.0909097052904476 0.291110311603925 LGR4/GJA1/MAGED1/BMP7/BTBD7/FOXP1/CTNNB1 7 GO:0010592 positive regulation of lamellipodium assembly 4/1115 29/18722 0.0910571680798941 0.291110311603925 NCKAP1/ABI2/OCLN/WASF2 4 GO:0015868 purine ribonucleotide transport 4/1115 29/18722 0.0910571680798941 0.291110311603925 SLC19A1/GJA1/CD47/SLC29A1 4 GO:0021591 ventricular system development 4/1115 29/18722 0.0910571680798941 0.291110311603925 SEMA6D/CDK6/TSKU/RAPGEF2 4 GO:0021602 cranial nerve morphogenesis 4/1115 29/18722 0.0910571680798941 0.291110311603925 NRP2/NRP1/SEMA3F/GLI3 4 GO:0030970 retrograde protein transport, ER to cytosol 4/1115 29/18722 0.0910571680798941 0.291110311603925 HSP90B1/SEL1L/ERLEC1/HM13 4 GO:0032366 intracellular sterol transport 4/1115 29/18722 0.0910571680798941 0.291110311603925 ABCA1/SYT7/NPC1/ANXA2 4 GO:0032367 intracellular cholesterol transport 4/1115 29/18722 0.0910571680798941 0.291110311603925 ABCA1/SYT7/NPC1/ANXA2 4 GO:0034311 diol metabolic process 4/1115 29/18722 0.0910571680798941 0.291110311603925 ASAH1/PLPP3/SGPP1/SPTLC3 4 GO:0060441 epithelial tube branching involved in lung morphogenesis 4/1115 29/18722 0.0910571680798941 0.291110311603925 DAG1/DLG5/FGFR2/CTNNB1 4 GO:0060969 negative regulation of gene silencing 4/1115 29/18722 0.0910571680798941 0.291110311603925 NEAT1/KCNQ1OT1/NCOR1/PPP3CA 4 GO:0062098 regulation of programmed necrotic cell death 4/1115 29/18722 0.0910571680798941 0.291110311603925 ASAH1/CFLAR/CAV1/YBX3 4 GO:0070198 protein localization to chromosome, telomeric region 4/1115 29/18722 0.0910571680798941 0.291110311603925 ATRX/TNKS2/TPP1/CCT3 4 GO:0071549 cellular response to dexamethasone stimulus 4/1115 29/18722 0.0910571680798941 0.291110311603925 EGFR/SERPINF1/NR3C1/CFLAR 4 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/1115 29/18722 0.0910571680798941 0.291110311603925 PPIA/P4HB/HSPB1/SOD1 4 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 4/1115 29/18722 0.0910571680798941 0.291110311603925 TPT1/MIF/CD74/USP47 4 GO:1903513 endoplasmic reticulum to cytosol transport 4/1115 29/18722 0.0910571680798941 0.291110311603925 HSP90B1/SEL1L/ERLEC1/HM13 4 GO:1903902 positive regulation of viral life cycle 4/1115 29/18722 0.0910571680798941 0.291110311603925 CD74/DDB1/P4HB/TRIM38 4 GO:0098661 inorganic anion transmembrane transport 9/1115 91/18722 0.0919237294268704 0.293704842256171 SLC26A2/SLC13A4/PCYOX1/GABRE/ANO6/SLC5A6/ANKH/SLC1A3/CLCN3 9 GO:0008306 associative learning 8/1115 78/18722 0.0921321084159068 0.294018724944726 ITGB1/LGMN/APP/NF1/MEIS2/TPBG/PIAS1/CLN3 8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 8/1115 78/18722 0.0921321084159068 0.294018724944726 USP47/IFI6/SIAH2/DHCR24/XIAP/SERPINB9/BIRC5/PRDX3 8 GO:0000910 cytokinesis 15/1115 173/18722 0.0925784590365725 0.295266662363358 SON/CALM1/ANK3/PLEC/SPTBN1/RASA1/BIRC6/PKN2/SNX18/ROCK1/RAB11FIP4/MYH10/SETD2/NUSAP1/RHOA 15 GO:1903202 negative regulation of oxidative stress-induced cell death 6/1115 53/18722 0.0938557687027347 0.298983263188485 MET/PPIA/HSPB1/OXR1/REST/CTNNB1 6 GO:1990090 cellular response to nerve growth factor stimulus 6/1115 53/18722 0.0938557687027347 0.298983263188485 APP/BPTF/KIDINS220/HSPA5/ARPC3/RAPGEF2 6 GO:0010907 positive regulation of glucose metabolic process 5/1115 41/18722 0.0947071646209582 0.300977114232914 DDB1/EPM2AIP1/SORBS1/HMGB1/INSR 5 GO:0031062 positive regulation of histone methylation 5/1115 41/18722 0.0947071646209582 0.300977114232914 BRD4/RIF1/JARID2/KMT2A/CTNNB1 5 GO:0055023 positive regulation of cardiac muscle tissue growth 5/1115 41/18722 0.0947071646209582 0.300977114232914 TGFBR3/RBPJ/MAPK14/BMPR1A/FGFR2 5 GO:1905314 semi-lunar valve development 5/1115 41/18722 0.0947071646209582 0.300977114232914 JAG1/ROCK1/GJA5/RBPJ/BMPR2 5 GO:0007569 cell aging 12/1115 132/18722 0.094810770117664 0.301127127696733 MME/CDK6/NPM1/MIF/PRKDC/YBX1/AKT3/MAPK14/BMPR1A/ATM/PLA2R1/SOD1 12 GO:0000041 transition metal ion transport 10/1115 105/18722 0.0953041768809674 0.302514268946186 FTH1/SLC40A1/SLC39A10/CLTC/SLC11A2/SLC30A7/TFRC/IREB2/ATP7B/FTL 10 GO:0007584 response to nutrient 15/1115 174/18722 0.0960441992279223 0.304682103195411 EGFR/ATP2B1/AGL/LDHA/ABCA1/SLC6A4/BMP7/DNMT3A/FOLR1/GSTP1/SLC16A1/TTPA/CCND1/ACSL3/CAT 15 GO:0051091 positive regulation of DNA-binding transcription factor activity 21/1115 260/18722 0.0966156503383943 0.306312919926774 LRP5/NPM1/APP/PLPP3/PPIA/RPS3/RPS6KA5/TFRC/PRKCI/CFLAR/CAV1/ARID5B/PPP3CA/TLR3/TRIM38/CAT/MAVS/TRIM13/CTNNB1/HSPA1A/PRDX3 21 GO:0045600 positive regulation of fat cell differentiation 7/1115 66/18722 0.0967637589325949 0.306399699103528 LRP5/ZFP36L1/BMP7/ADIRF/CDS1/TMEM64/MAPK14 7 GO:0001708 cell fate specification 9/1115 92/18722 0.0968151886847072 0.306399699103528 ITGB1/NRP1/RBPJ/GLI3/ESRP1/BMPR1A/ISL1/MGA/CTNNB1 9 GO:1903312 negative regulation of mRNA metabolic process 9/1115 92/18722 0.0968151886847072 0.306399699103528 NPM1/YBX1/MAPK14/HNRNPC/HNRNPD/SAP18/FUS/SRSF9/YBX3 9 GO:0001895 retina homeostasis 8/1115 79/18722 0.0974680613243982 0.307736238563549 SLC2A1/PRDX1/ACTG1/SLC28A2/CLCN3/HSPB1/ACTB/SOD1 8 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 8/1115 79/18722 0.0974680613243982 0.307736238563549 NRP1/PRKDC/CUX1/CDKL5/P4HB/S100A10/DHX36/OBSL1 8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 8/1115 79/18722 0.0974680613243982 0.307736238563549 FLT1/IGF1R/PLXNB1/ERBB3/FN1/PDGFD/INSR/CAT 8 GO:0060420 regulation of heart growth 8/1115 79/18722 0.0974680613243982 0.307736238563549 GJA1/TGFBR3/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 8 GO:0008202 steroid metabolic process 25/1115 319/18722 0.0980037307858024 0.309244632780969 LRP2/LRP5/STS/PBX1/ABCA1/PRLR/SLC27A2/LGMN/APP/ASAH1/SF1/LIPA/VLDLR/NPC1/SMPD1/ATP1A1/DHCR24/NFE2L1/ABCD3/TSKU/SREBF2/LPCAT3/REST/CAT/SOD1 25 GO:0046578 regulation of Ras protein signal transduction 16/1115 189/18722 0.099084357688544 0.312084824525065 ADGRG1/MET/ITGB1/KANK1/NRP1/ABCA1/RASA1/ARFGEF1/NET1/AKAP13/DENND4C/ARFGEF3/F11R/CYTH3/CCDC125/CDC42SE1 16 GO:0036294 cellular response to decreased oxygen levels 14/1115 161/18722 0.0997868667404027 0.312084824525065 MALAT1/ZFP36L1/BMP7/DNMT3A/MDM4/ENO1/SLC9A1/P4HB/NPEPPS/CHCHD2/CPEB4/RBPJ/SLC29A1/CFLAR 14 GO:0006906 vesicle fusion 10/1115 106/18722 0.0999400712192643 0.312084824525065 ANXA1/EEA1/USO1/SYT7/KIF5B/YIPF4/VAV3/CLN3/RAB13/ANXA2 10 GO:0009185 ribonucleoside diphosphate metabolic process 10/1115 106/18722 0.0999400712192643 0.312084824525065 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/DLG1/TPI1/AK3/INSR 10 GO:1903707 negative regulation of hemopoiesis 10/1115 106/18722 0.0999400712192643 0.312084824525065 FBN1/ANXA1/CDK6/CD74/GLI3/HMGB1/TLR3/RC3H1/ERBB2/CTNNB1 10 GO:0000028 ribosomal small subunit assembly 3/1115 19/18722 0.100253846841463 0.312084824525065 PRKDC/RPSA/RPL38 3 GO:0002902 regulation of B cell apoptotic process 3/1115 19/18722 0.100253846841463 0.312084824525065 SLC39A10/CD74/FOXP1 3 GO:0030011 maintenance of cell polarity 3/1115 19/18722 0.100253846841463 0.312084824525065 DST/DLG5/SLC9A1 3 GO:0032011 ARF protein signal transduction 3/1115 19/18722 0.100253846841463 0.312084824525065 ARFGEF1/ARFGEF3/CYTH3 3 GO:0032012 regulation of ARF protein signal transduction 3/1115 19/18722 0.100253846841463 0.312084824525065 ARFGEF1/ARFGEF3/CYTH3 3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 3/1115 19/18722 0.100253846841463 0.312084824525065 TECR/ACSL3/ELOVL1 3 GO:0036498 IRE1-mediated unfolded protein response 3/1115 19/18722 0.100253846841463 0.312084824525065 UFL1/HSPA5/TMEM33 3 GO:0045019 negative regulation of nitric oxide biosynthetic process 3/1115 19/18722 0.100253846841463 0.312084824525065 ATP2B4/DYNLL1/CAV1 3 GO:0051444 negative regulation of ubiquitin-protein transferase activity 3/1115 19/18722 0.100253846841463 0.312084824525065 RPS20/RPL23/RPL5 3 GO:0060039 pericardium development 3/1115 19/18722 0.100253846841463 0.312084824525065 BMP7/SMAD2/SETD2 3 GO:0070262 peptidyl-serine dephosphorylation 3/1115 19/18722 0.100253846841463 0.312084824525065 YWHAE/PPP1R15B/PPP3CA 3 GO:0140131 positive regulation of lymphocyte chemotaxis 3/1115 19/18722 0.100253846841463 0.312084824525065 ADAM10/ADAM17/WNK1 3 GO:1903204 negative regulation of oxidative stress-induced neuron death 3/1115 19/18722 0.100253846841463 0.312084824525065 OXR1/REST/CTNNB1 3 GO:1904406 negative regulation of nitric oxide metabolic process 3/1115 19/18722 0.100253846841463 0.312084824525065 ATP2B4/DYNLL1/CAV1 3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 4/1115 30/18722 0.100365170202198 0.312084824525065 APP/CALM1/BMP7/S1PR2 4 GO:0015865 purine nucleotide transport 4/1115 30/18722 0.100365170202198 0.312084824525065 SLC19A1/GJA1/CD47/SLC29A1 4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 4/1115 30/18722 0.100365170202198 0.312084824525065 LGMN/CD74/CTSD/CTSF 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/1115 30/18722 0.100365170202198 0.312084824525065 PRKDC/RPL26/CCND1/ATM 4 GO:0046825 regulation of protein export from nucleus 4/1115 30/18722 0.100365170202198 0.312084824525065 TPR/YWHAE/PTPN14/TCF7L2 4 GO:0070229 negative regulation of lymphocyte apoptotic process 4/1115 30/18722 0.100365170202198 0.312084824525065 SLC39A10/CD74/DOCK8/FOXP1 4 GO:0072348 sulfur compound transport 6/1115 54/18722 0.100568295362206 0.31238884152071 SLC26A2/SLC13A4/GJA1/SLC19A3/SLC5A6/SLC13A3 6 GO:0050803 regulation of synapse structure or activity 18/1115 218/18722 0.100579962272729 0.31238884152071 DAG1/NRP2/APP/CFL1/SEMA3F/CDKL5/ADAM10/DLG5/CLSTN1/PPP1R9A/TPBG/DHX36/CLN3/MAPK14/ABI2/CDC20/ARF4/RHOA 18 GO:0097306 cellular response to alcohol 9/1115 93/18722 0.101854455706126 0.316163336636632 DAG1/ATP2B1/CDH1/ABCA1/ITPR2/DNMT3A/ADCY7/XRN1/CTNNB1 9 GO:0030218 erythrocyte differentiation 11/1115 120/18722 0.101928099361758 0.316208089768987 CDK6/RPS6/ZFP36L1/TGFBR3/PRKDC/SLC11A2/UFL1/PTBP3/MAPK14/P4HTM/HSPA1A 11 GO:0000413 protein peptidyl-prolyl isomerization 5/1115 42/18722 0.10252466141273 0.31677035143667 NKTR/PPIA/RANBP2/PPIG/FKBP14 5 GO:0016601 Rac protein signal transduction 5/1115 42/18722 0.10252466141273 0.31677035143667 HACD3/NCKAP1/NISCH/ABI2/WASF2 5 GO:0021879 forebrain neuron differentiation 5/1115 42/18722 0.10252466141273 0.31677035143667 NRP2/NRP1/SCYL2/FGFR2/RAPGEF2 5 GO:0030890 positive regulation of B cell proliferation 5/1115 42/18722 0.10252466141273 0.31677035143667 SLC39A10/MIF/CD74/TFRC/VAV3 5 GO:0035019 somatic stem cell population maintenance 5/1115 42/18722 0.10252466141273 0.31677035143667 LRP5/BMP7/KLF10/RBPJ/REST 5 GO:0051602 response to electrical stimulus 5/1115 42/18722 0.10252466141273 0.31677035143667 AKAP9/SLC9A1/REST/FZD3/HNRNPD 5 GO:0060999 positive regulation of dendritic spine development 5/1115 42/18722 0.10252466141273 0.31677035143667 CDKL5/DLG5/PPP1R9A/DHX36/C21orf91 5 GO:0043534 blood vessel endothelial cell migration 15/1115 176/18722 0.103214878765529 0.318718471792458 ITGB1/ANXA1/NRP1/ATP2B4/NF1/P2RX4/EPHB4/AMOT/ADAM17/TMSB4X/MIA3/HSPB1/AKT3/HMGB1/RHOA 15 GO:0014074 response to purine-containing compound 13/1115 148/18722 0.10357160940673 0.319266063869821 AKAP9/LDHA/HSP90B1/SLC6A4/APP/ZFP36L1/P2RX4/ITPR2/HSPA5/XRN1/PKD2/RAPGEF2/SOD1 13 GO:0044272 sulfur compound biosynthetic process 13/1115 148/18722 0.10357160940673 0.319266063869821 SLC26A2/CHPF/ACSS1/DSE/GSTP1/B3GNT2/CHST11/B3GNT3/MTR/CHST14/TECR/ACSL3/ELOVL1 13 GO:0050905 neuromuscular process 13/1115 148/18722 0.10357160940673 0.319266063869821 MYCBP2/APP/GAA/IGDCC3/HEXB/TMEM150C/GM2A/ATP2A2/SLC1A3/TPP1/DMD/MYO7A/CLN3 13 GO:0021761 limbic system development 10/1115 107/18722 0.104705393063205 0.32238875061387 NRP2/CDK6/NRP1/ATP2B4/KIF5B/GLI3/RAB3GAP1/TSKU/FGFR2/UBA6 10 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 10/1115 107/18722 0.104705393063205 0.32238875061387 HECTD1/RNF217/ZYG11B/PIAS1/RNF19A/CAV1/DDA1/CSNK1A1/CDC20/HSPA1A 10 GO:0042752 regulation of circadian rhythm 11/1115 121/18722 0.106442582268277 0.32754867246705 ADRB1/PRKDC/ZFHX3/MAGED1/GNAQ/DDB1/USP9X/KLF10/SIAH2/OPN3/HNRNPD 11 GO:0010389 regulation of G2/M transition of mitotic cell cycle 9/1115 94/18722 0.107040668264988 0.32896308321598 PBX1/APP/BRD4/USP47/TAOK1/TAOK3/CCND1/FOXO4/ATM 9 GO:1903706 regulation of hemopoiesis 28/1115 367/18722 0.107061704408752 0.32896308321598 FBN1/CSF3R/CD46/ANXA1/CDK6/ZFP36L1/SCIN/CD74/PRKDC/ATP6AP1/JAG1/MEIS2/KLF10/TMEM64/GLI3/PURB/FOXP1/HMGB1/MAPK14/P4HTM/TLR3/CLPTM1/RC3H1/ERBB2/CTNNB1/HSPA1A/RHOA/SOD1 28 GO:0031503 protein-containing complex localization 18/1115 220/18722 0.107139233255774 0.32896308321598 AKAP9/DAG1/NPM1/TPR/ADAM10/SRSF3/SMG1/DLG1/PCM1/CLSTN1/KIF5B/THOC2/WASL/SETD2/HNRNPA2B1/RAN/ATM/BIRC5 18 GO:0032103 positive regulation of response to external stimulus 32/1115 427/18722 0.107148679848771 0.32896308321598 EGFR/NEAT1/LRP1/IL6ST/MET/GRN/NRP1/LGMN/APP/CTSC/CD74/ANO6/PRKDC/P2RX4/ADAM10/CD47/TPBG/PUM2/ADAM17/WNK1/TRPV4/BMPR2/TMSB4X/HSPB1/PUM1/HMGB1/PDGFD/TLR3/ANKRD17/MAVS/CREBBP/CADM1 32 GO:0003179 heart valve morphogenesis 6/1115 55/18722 0.107526315638241 0.329176031647114 MDM4/JAG1/ROCK1/GJA5/BMPR2/BMPR1A 6 GO:0043331 response to dsRNA 6/1115 55/18722 0.107526315638241 0.329176031647114 COLEC12/NPM1/DHX36/CAV1/TLR3/MAVS 6 GO:0044091 membrane biogenesis 6/1115 55/18722 0.107526315638241 0.329176031647114 SERINC1/ANK3/SPTBN1/S100A10/CAV1/ANXA2 6 GO:0045620 negative regulation of lymphocyte differentiation 6/1115 55/18722 0.107526315638241 0.329176031647114 ANXA1/CD74/GLI3/HMGB1/RC3H1/ERBB2 6 GO:0048016 inositol phosphate-mediated signaling 6/1115 55/18722 0.107526315638241 0.329176031647114 ATP2B4/NFAT5/ITPR2/SLC9A1/NFATC3/PPP3CA 6 GO:0006096 glycolytic process 8/1115 81/18722 0.108651915921894 0.332240881504577 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/INSR 8 GO:2001021 negative regulation of response to DNA damage stimulus 8/1115 81/18722 0.108651915921894 0.332240881504577 TPT1/MIF/CD74/RPS3/USP47/UBR5/RIF1/TRIP12 8 GO:0045930 negative regulation of mitotic cell cycle 19/1115 235/18722 0.108889772358606 0.332777615696964 EGFR/ZFP36L1/PRKDC/BMP7/TPR/USP47/RPL26/TAOK1/DLG1/TAOK3/JADE1/CCND1/ZNF207/PKD2/FZD3/FOXO4/ATM/CTNNB1/CDKN1C 19 GO:0032922 circadian regulation of gene expression 7/1115 68/18722 0.109078418587047 0.332782672477854 LGR4/MYCBP2/ZFHX3/MAGED1/KDM5A/NCOA2/KMT2A 7 GO:0042987 amyloid precursor protein catabolic process 7/1115 68/18722 0.109078418587047 0.332782672477854 RTN4/ADAM10/ROCK1/NCSTN/ADAM17/DHCR24/CLN3 7 GO:1901016 regulation of potassium ion transmembrane transporter activity 7/1115 68/18722 0.109078418587047 0.332782672477854 AKAP9/ITGB1/ANK3/YWHAE/DLG1/CAV1/ALG10B 7 GO:0018209 peptidyl-serine modification 26/1115 338/18722 0.109141705557435 0.332785588789916 EGFR/AKAP9/APP/ATP2B4/MIF/PRKDC/HSP90AB1/RPS6KA5/PKN2/SMG1/ROCK1/NSD1/TFRC/TGFBR1/RICTOR/PRKCI/GPD1L/DMD/LATS2/WNK1/AKT3/MAPK14/CAV1/CSNK1A1/MAST4/ATM 26 GO:0007173 epidermal growth factor receptor signaling pathway 10/1115 108/18722 0.109599495387505 0.333968652924588 EGFR/EFEMP1/IQGAP1/RPS6KA5/GAB1/IFI6/ADAM17/GAREM1/RHBDF1/ARF4 10 GO:0001516 prostaglandin biosynthetic process 4/1115 31/18722 0.110092681990499 0.333968652924588 ANXA1/MIF/CD74/PTGES3 4 GO:0007190 activation of adenylate cyclase activity 4/1115 31/18722 0.110092681990499 0.333968652924588 LGR5/LGR4/ADRB1/CALM1 4 GO:0008045 motor neuron axon guidance 4/1115 31/18722 0.110092681990499 0.333968652924588 NRP1/MYCBP2/SEMA3F/ERBB2 4 GO:0036475 neuron death in response to oxidative stress 4/1115 31/18722 0.110092681990499 0.333968652924588 ARL6IP5/OXR1/REST/CTNNB1 4 GO:0044819 mitotic G1/S transition checkpoint signaling 4/1115 31/18722 0.110092681990499 0.333968652924588 PRKDC/RPL26/CCND1/ATM 4 GO:0046457 prostanoid biosynthetic process 4/1115 31/18722 0.110092681990499 0.333968652924588 ANXA1/MIF/CD74/PTGES3 4 GO:0070723 response to cholesterol 4/1115 31/18722 0.110092681990499 0.333968652924588 DAG1/ABCA1/TGFBR1/SMAD2 4 GO:1900027 regulation of ruffle assembly 4/1115 31/18722 0.110092681990499 0.333968652924588 KANK1/PFN1/COBL/CAV1 4 GO:0001504 neurotransmitter uptake 5/1115 43/18722 0.110651624647431 0.334304315117434 ITGB1/SLC6A4/SLC38A1/SLC1A3/SLC29A1 5 GO:0009268 response to pH 5/1115 43/18722 0.110651624647431 0.334304315117434 LGMN/GJA1/SERPINF1/SLC9A1/TTPA 5 GO:0033173 calcineurin-NFAT signaling cascade 5/1115 43/18722 0.110651624647431 0.334304315117434 ATP2B4/NFAT5/SLC9A1/NFATC3/PPP3CA 5 GO:0060443 mammary gland morphogenesis 5/1115 43/18722 0.110651624647431 0.334304315117434 LRP5/GLI3/DDR1/CAV1/FGFR2 5 GO:1901381 positive regulation of potassium ion transmembrane transport 5/1115 43/18722 0.110651624647431 0.334304315117434 AKAP9/ANO6/KCNN4/WNK1/ALG10B 5 GO:1903793 positive regulation of anion transport 5/1115 43/18722 0.110651624647431 0.334304315117434 TCAF1/ITGB1/P2RX4/RAB3GAP1/PLA2R1 5 GO:0009266 response to temperature stimulus 15/1115 178/18722 0.110704257188167 0.334304315117434 ATP2B1/ADRB1/TPR/HSP90AB1/YWHAE/SLC9A1/ATP2A2/TRPV4/DNAJC3/DHX36/DNAJA1/CREBBP/ATM/HSPA1A/SOD1 15 GO:0035725 sodium ion transmembrane transport 15/1115 178/18722 0.110704257188167 0.334304315117434 UTRN/SLC6A4/ATP2B4/ANO6/ANK3/SLC9A1/DLG1/ACTN4/KIF5B/GPD1L/DMD/ATP1A1/WNK1/STOM/PKD2 15 GO:0050792 regulation of viral process 14/1115 164/18722 0.111433968615788 0.335565514862236 HACD3/CD74/PPIA/PKN2/DDB1/P4HB/RSF1/MPHOSPH8/TOP2B/LY6E/STOM/TRIM38/MAVS/TRIM13 14 GO:0030522 intracellular receptor signaling pathway 21/1115 265/18722 0.111539241075806 0.335565514862236 DDX17/PTGES3/NR3C1/ESRRG/UBR5/NCOR1/ACTN4/UFL1/ARID1A/NR2F2/PUM2/SKP2/FOXP1/PUM1/XIAP/DHRS3/ISL1/ANKRD17/DNAJA1/HSPA1A/RHOA 21 GO:0006790 sulfur compound metabolic process 26/1115 339/18722 0.111872631354977 0.335565514862236 SLC26A2/CHPF/GNS/ACSS1/GLB1/SLC19A3/ARL6IP5/SMS/TPST2/DSE/GSTP1/B3GNT2/AHCYL1/CHST11/B3GNT3/MTR/CHST14/TECR/TSTD1/ACSL3/CLIC3/IDH1/ELOVL1/FASN/GPAT4/SOD1 26 GO:0030072 peptide hormone secretion 19/1115 236/18722 0.112187289470921 0.335565514862236 EGFR/LRP1/ANXA1/LRP5/DPP4/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/TRPV4/SMAD2/EFNA5/PPP3CA/REST/ISL1 19 GO:0008593 regulation of Notch signaling pathway 9/1115 95/18722 0.11237275446362 0.335565514862236 CD46/IL6ST/GALNT11/AAK1/BMP7/ADAM10/JAG1/PRKCI/SREBF2 9 GO:0036473 cell death in response to oxidative stress 9/1115 95/18722 0.11237275446362 0.335565514862236 MET/PPIA/ARL6IP5/P4HB/HSPB1/OXR1/REST/CTNNB1/SOD1 9 GO:0050764 regulation of phagocytosis 9/1115 95/18722 0.11237275446362 0.335565514862236 LRP1/ITGAV/ANO6/SYT7/CD47/HMGB1/APPL1/RAB31/SOD1 9 GO:0021700 developmental maturation 22/1115 280/18722 0.112510187730405 0.335565514862236 DAG1/PFN1/APP/PLXNB1/NRCAM/B4GALT5/FZD5/CLSTN1/FERMT1/CLN5/CLCN3/RBPJ/PTBP3/TFCP2L1/FEM1B/EDNRB/ANKRD17/RERE/CTNNB1/CDC20/GPAT4/RHOA 22 GO:0003215 cardiac right ventricle morphogenesis 3/1115 20/18722 0.112968691077904 0.335565514862236 JAG1/BMPR1A/ISL1 3 GO:0006346 DNA methylation-dependent heterochromatin assembly 3/1115 20/18722 0.112968691077904 0.335565514862236 DNMT3A/MPHOSPH8/ATF7IP 3 GO:0006883 cellular sodium ion homeostasis 3/1115 20/18722 0.112968691077904 0.335565514862236 SLC9A1/SLC1A3/ATP1A1 3 GO:0007097 nuclear migration 3/1115 20/18722 0.112968691077904 0.335565514862236 SYNE2/PCM1/DYNC1H1 3 GO:0032930 positive regulation of superoxide anion generation 3/1115 20/18722 0.112968691077904 0.335565514862236 EGFR/GSTP1/SOD1 3 GO:0032986 protein-DNA complex disassembly 3/1115 20/18722 0.112968691077904 0.335565514862236 RPL23/ARID1A/SMARCC1 3 GO:0039535 regulation of RIG-I signaling pathway 3/1115 20/18722 0.112968691077904 0.335565514862236 PUM2/PUM1/ANKRD17 3 GO:0043555 regulation of translation in response to stress 3/1115 20/18722 0.112968691077904 0.335565514862236 NPM1/DNAJC3/PPP1R15B 3 GO:0043586 tongue development 3/1115 20/18722 0.112968691077904 0.335565514862236 EGFR/GLI3/CTNNB1 3 GO:0048025 negative regulation of mRNA splicing, via spliceosome 3/1115 20/18722 0.112968691077904 0.335565514862236 NPM1/SAP18/SRSF9 3 GO:0071243 cellular response to arsenic-containing substance 3/1115 20/18722 0.112968691077904 0.335565514862236 HNRNPA1/SLC38A2/DHX36 3 GO:0071731 response to nitric oxide 3/1115 20/18722 0.112968691077904 0.335565514862236 MTR/CFLAR/HNRNPD 3 GO:0097150 neuronal stem cell population maintenance 3/1115 20/18722 0.112968691077904 0.335565514862236 JAG1/PCM1/REST 3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/1115 20/18722 0.112968691077904 0.335565514862236 GRINA/HSPA1A/WFS1 3 GO:1904292 regulation of ERAD pathway 3/1115 20/18722 0.112968691077904 0.335565514862236 USP25/TMEM259/CAV1 3 GO:2000479 regulation of cAMP-dependent protein kinase activity 3/1115 20/18722 0.112968691077904 0.335565514862236 ATP2B4/PKIB/RAPGEF2 3 GO:0001935 endothelial cell proliferation 16/1115 193/18722 0.113395393853358 0.335565514862236 NRP2/FLT1/NRP1/NF1/GJA1/DLG1/TGFBR1/RICTOR/NR2F2/ADAM17/PTPRM/BMPR2/EMC10/AKT3/HMGB1/CAV1 16 GO:0046700 heterocycle catabolic process 33/1115 445/18722 0.114121587681632 0.335565514862236 NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/TET2/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/PDE10A/PDE7A/TDG/RC3H1/ATM/MGAT1/HSPA1A/HNRNPD/SND1/FUS/YBX3 33 GO:0006757 ATP generation from ADP 8/1115 82/18722 0.114496677616367 0.335565514862236 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/INSR 8 GO:0001936 regulation of endothelial cell proliferation 15/1115 179/18722 0.114568149137361 0.335565514862236 NRP2/FLT1/NRP1/NF1/GJA1/TGFBR1/RICTOR/NR2F2/ADAM17/PTPRM/BMPR2/EMC10/AKT3/HMGB1/CAV1 15 GO:0022029 telencephalon cell migration 6/1115 56/18722 0.114725427011641 0.335565514862236 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1/RHOA 6 GO:0046622 positive regulation of organ growth 6/1115 56/18722 0.114725427011641 0.335565514862236 TGFBR3/RBPJ/MAPK14/BMPR1A/FGFR2/YBX3 6 GO:0048255 mRNA stabilization 6/1115 56/18722 0.114725427011641 0.335565514862236 YBX1/MAPK14/HNRNPC/HNRNPD/FUS/YBX3 6 GO:1990089 response to nerve growth factor 6/1115 56/18722 0.114725427011641 0.335565514862236 APP/BPTF/KIDINS220/HSPA5/ARPC3/RAPGEF2 6 GO:0010611 regulation of cardiac muscle hypertrophy 7/1115 69/18722 0.115533986312528 0.335565514862236 IL6ST/ATP2B4/P2RX4/SLC9A1/ROCK1/JARID2/PPP3CA 7 GO:0031060 regulation of histone methylation 7/1115 69/18722 0.115533986312528 0.335565514862236 ATRX/BRD4/RIF1/NSD1/JARID2/KMT2A/CTNNB1 7 GO:0071456 cellular response to hypoxia 13/1115 151/18722 0.116078752072921 0.335565514862236 MALAT1/ZFP36L1/BMP7/DNMT3A/MDM4/ENO1/SLC9A1/P4HB/NPEPPS/CHCHD2/RBPJ/SLC29A1/CFLAR 13 GO:0002002 regulation of angiotensin levels in blood 2/1115 10/18722 0.116087189726644 0.335565514862236 MME/ENPEP 2 GO:0002003 angiotensin maturation 2/1115 10/18722 0.116087189726644 0.335565514862236 MME/ENPEP 2 GO:0003183 mitral valve morphogenesis 2/1115 10/18722 0.116087189726644 0.335565514862236 BMPR2/BMPR1A 2 GO:0005984 disaccharide metabolic process 2/1115 10/18722 0.116087189726644 0.335565514862236 GAA/B4GALT1 2 GO:0006012 galactose metabolic process 2/1115 10/18722 0.116087189726644 0.335565514862236 GLB1/B4GALT1 2 GO:0006560 proline metabolic process 2/1115 10/18722 0.116087189726644 0.335565514862236 ALDH18A1/ALDH4A1 2 GO:0006646 phosphatidylethanolamine biosynthetic process 2/1115 10/18722 0.116087189726644 0.335565514862236 PISD/ETNK1 2 GO:0007028 cytoplasm organization 2/1115 10/18722 0.116087189726644 0.335565514862236 KIF5B/TFCP2L1 2 GO:0016139 glycoside catabolic process 2/1115 10/18722 0.116087189726644 0.335565514862236 GUSB/FUCA1 2 GO:0021562 vestibulocochlear nerve development 2/1115 10/18722 0.116087189726644 0.335565514862236 NRP2/NRP1 2 GO:0021932 hindbrain radial glia guided cell migration 2/1115 10/18722 0.116087189726644 0.335565514862236 ITGB1/RERE 2 GO:0030953 astral microtubule organization 2/1115 10/18722 0.116087189726644 0.335565514862236 DLG1/KPNB1 2 GO:0031943 regulation of glucocorticoid metabolic process 2/1115 10/18722 0.116087189726644 0.335565514862236 ATP1A1/REST 2 GO:0033572 transferrin transport 2/1115 10/18722 0.116087189726644 0.335565514862236 CLTC/TFRC 2 GO:0035907 dorsal aorta development 2/1115 10/18722 0.116087189726644 0.335565514862236 RBPJ/BMPR1A 2 GO:0040015 negative regulation of multicellular organism growth 2/1115 10/18722 0.116087189726644 0.335565514862236 LGMN/ADRB1 2 GO:0042045 epithelial fluid transport 2/1115 10/18722 0.116087189726644 0.335565514862236 AHCYL1/EDNRB 2 GO:0042989 sequestering of actin monomers 2/1115 10/18722 0.116087189726644 0.335565514862236 SCIN/TMSB4X 2 GO:0044848 biological phase 2/1115 10/18722 0.116087189726644 0.335565514862236 FERMT1/CTNNB1 2 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence 2/1115 10/18722 0.116087189726644 0.335565514862236 EMC1/EMC10 2 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 2/1115 10/18722 0.116087189726644 0.335565514862236 HMGB1/ATF7IP 2 GO:0048280 vesicle fusion with Golgi apparatus 2/1115 10/18722 0.116087189726644 0.335565514862236 USO1/YIPF4 2 GO:0048340 paraxial mesoderm morphogenesis 2/1115 10/18722 0.116087189726644 0.335565514862236 SMAD2/BMPR1A 2 GO:0048703 embryonic viscerocranium morphogenesis 2/1115 10/18722 0.116087189726644 0.335565514862236 NIPBL/CHST11 2 GO:0050861 positive regulation of B cell receptor signaling pathway 2/1115 10/18722 0.116087189726644 0.335565514862236 SLC39A10/FOXP1 2 GO:0051409 response to nitrosative stress 2/1115 10/18722 0.116087189726644 0.335565514862236 DNAJA1/ATM 2 GO:0060272 embryonic skeletal joint morphogenesis 2/1115 10/18722 0.116087189726644 0.335565514862236 BMP7/CTNNB1 2 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 2/1115 10/18722 0.116087189726644 0.335565514862236 CD47/APPL1 2 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 2/1115 10/18722 0.116087189726644 0.335565514862236 SERPINF1/CTNNB1 2 GO:0071803 positive regulation of podosome assembly 2/1115 10/18722 0.116087189726644 0.335565514862236 ASAP1/RHOA 2 GO:0072178 nephric duct morphogenesis 2/1115 10/18722 0.116087189726644 0.335565514862236 AHI1/GPC3 2 GO:0072203 cell proliferation involved in metanephros development 2/1115 10/18722 0.116087189726644 0.335565514862236 BMP7/GPC3 2 GO:0072378 blood coagulation, fibrin clot formation 2/1115 10/18722 0.116087189726644 0.335565514862236 FBLN1/FN1 2 GO:0090179 planar cell polarity pathway involved in neural tube closure 2/1115 10/18722 0.116087189726644 0.335565514862236 DVL3/PTK7 2 GO:0090647 modulation of age-related behavioral decline 2/1115 10/18722 0.116087189726644 0.335565514862236 APP/BAZ2B 2 GO:0099532 synaptic vesicle endosomal processing 2/1115 10/18722 0.116087189726644 0.335565514862236 EEA1/ITSN2 2 GO:0140059 dendrite arborization 2/1115 10/18722 0.116087189726644 0.335565514862236 NRP1/TPBG 2 GO:1901524 regulation of mitophagy 2/1115 10/18722 0.116087189726644 0.335565514862236 VPS13C/VDAC1 2 GO:1902023 L-arginine transport 2/1115 10/18722 0.116087189726644 0.335565514862236 SLC38A9/SLC7A2 2 GO:1903826 arginine transmembrane transport 2/1115 10/18722 0.116087189726644 0.335565514862236 SLC38A9/SLC7A2 2 GO:1903867 extraembryonic membrane development 2/1115 10/18722 0.116087189726644 0.335565514862236 BMP7/FZD5 2 GO:1905383 protein localization to presynapse 2/1115 10/18722 0.116087189726644 0.335565514862236 KIF5B/HSPB1 2 GO:1990535 neuron projection maintenance 2/1115 10/18722 0.116087189726644 0.335565514862236 APP/INSR 2 GO:2000288 positive regulation of myoblast proliferation 2/1115 10/18722 0.116087189726644 0.335565514862236 MALAT1/MEIS2 2 GO:0030879 mammary gland development 12/1115 137/18722 0.116234758321383 0.335810267682825 LRP5/PRLR/ARHGAP5/RTN4/SLC29A1/GLI3/DDR1/CAV1/CCND1/FGFR2/FASN/GPAT4 12 GO:0055017 cardiac muscle tissue growth 9/1115 96/18722 0.117849436018571 0.340291043214251 GJA1/TGFBR3/AKAP13/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 9 GO:0005978 glycogen biosynthetic process 5/1115 44/18722 0.119079644779774 0.342361994334525 AGL/PTGES3/EPM2AIP1/SORBS1/INSR 5 GO:0008542 visual learning 5/1115 44/18722 0.119079644779774 0.342361994334525 ITGB1/APP/NF1/MEIS2/PIAS1 5 GO:0009250 glucan biosynthetic process 5/1115 44/18722 0.119079644779774 0.342361994334525 AGL/PTGES3/EPM2AIP1/SORBS1/INSR 5 GO:0032881 regulation of polysaccharide metabolic process 5/1115 44/18722 0.119079644779774 0.342361994334525 CLTC/EPM2AIP1/SORBS1/HMGB1/INSR 5 GO:0048806 genitalia development 5/1115 44/18722 0.119079644779774 0.342361994334525 LRP2/LGR4/NIPBL/DHCR24/CTNNB1 5 GO:0050999 regulation of nitric-oxide synthase activity 5/1115 44/18722 0.119079644779774 0.342361994334525 EGFR/ATP2B4/CALM1/CAV1/ZDHHC21 5 GO:0051150 regulation of smooth muscle cell differentiation 5/1115 44/18722 0.119079644779774 0.342361994334525 PIAS1/NFATC3/FGFR2/ANKRD17/FOXO4 5 GO:1903214 regulation of protein targeting to mitochondrion 5/1115 44/18722 0.119079644779774 0.342361994334525 LMAN1/FZD5/UBE2L3/NPEPPS/SREBF2 5 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 17/1115 209/18722 0.119288680899469 0.342778400065805 CTSD/RPS3/ARL6IP5/USP47/IFI6/SIAH2/DHCR24/HMGB1/CFLAR/XIAP/REST/SERPINB9/CYCS/BIRC5/HSPE1/PRDX3/RHOA 17 GO:0060538 skeletal muscle organ development 14/1115 166/18722 0.119628743726117 0.343427874246801 DAG1/PLEC/DDX17/GPC1/NR2F2/DMD/MAPK14/CFLAR/CAV1/MYL6/PPP3CA/CTNNB1/RHOA/YBX3 14 GO:0007088 regulation of mitotic nuclear division 10/1115 110/18722 0.119770653971323 0.343427874246801 LRP5/BMP7/TPR/PHIP/ZNF207/OBSL1/INSR/CDK13/ATM/NUSAP1 10 GO:0090174 organelle membrane fusion 10/1115 110/18722 0.119770653971323 0.343427874246801 ANXA1/EEA1/USO1/SYT7/KIF5B/YIPF4/VAV3/CLN3/RAB13/ANXA2 10 GO:0003338 metanephros morphogenesis 4/1115 32/18722 0.120222269519998 0.343427874246801 LGR4/FRAS1/PKD2/CTNNB1 4 GO:0009954 proximal/distal pattern formation 4/1115 32/18722 0.120222269519998 0.343427874246801 PBX1/GLI3/CTNNB1/IRX2 4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 4/1115 32/18722 0.120222269519998 0.343427874246801 NR2F2/LATS2/IPO7/CDKN1C 4 GO:0060323 head morphogenesis 4/1115 32/18722 0.120222269519998 0.343427874246801 NIPBL/ANKRD11/RAB3GAP1/ARID5B 4 GO:0061037 negative regulation of cartilage development 4/1115 32/18722 0.120222269519998 0.343427874246801 EFEMP1/LTBP3/TGFBR1/CTNNB1 4 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/1115 32/18722 0.120222269519998 0.343427874246801 GRINA/SERINC3/HSPA1A/WFS1 4 GO:1903955 positive regulation of protein targeting to mitochondrion 4/1115 32/18722 0.120222269519998 0.343427874246801 FZD5/UBE2L3/NPEPPS/SREBF2 4 GO:1905476 negative regulation of protein localization to membrane 4/1115 32/18722 0.120222269519998 0.343427874246801 HECTD1/CLTC/LYPLA1/PPFIA1 4 GO:1904062 regulation of cation transmembrane transport 27/1115 357/18722 0.120395389652663 0.343738494842551 AHNAK/AKAP9/ITGB1/UTRN/APP/ATP2B4/SLC43A2/CALM1/ANO6/ANK3/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KCNN4/KIF5B/VDAC1/GPD1L/DMD/WNK1/TMSB4X/CAV1/STOM/ALG10B/PKD2/VMP1 27 GO:0022407 regulation of cell-cell adhesion 33/1115 448/18722 0.121552590775434 0.346856911892059 TENM3/CD46/CDH1/IL6ST/ANXA1/DPP4/PLPP3/CD74/GCNT2/NFAT5/ANK3/RPS3/DOCK8/BMP7/DLG5/DLG1/JAG1/CD47/TFRC/WNK1/TRPV4/GLI3/F11R/MIA3/C1QTNF1/HMGB1/MAPK14/CAV1/ZDHHC21/EFNA5/RC3H1/ERBB2/RHOA 33 GO:0010883 regulation of lipid storage 6/1115 57/18722 0.122160680696581 0.347848466260824 ITGAV/PLIN2/ABCA1/MEST/OSBPL8/SREBF2 6 GO:0051205 protein insertion into membrane 6/1115 57/18722 0.122160680696581 0.347848466260824 EGFR/EMC1/TRAM1/CCDC47/EMC10/TRAM2 6 GO:0060042 retina morphogenesis in camera-type eye 6/1115 57/18722 0.122160680696581 0.347848466260824 LRP5/MAN2A1/PTPRM/NAGLU/AHI1/OBSL1 6 GO:0061005 cell differentiation involved in kidney development 6/1115 57/18722 0.122160680696581 0.347848466260824 LGR4/IQGAP1/JAG1/MTSS1/GLI3/CTNNB1 6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 14/1115 167/18722 0.123854205098454 0.352294939275784 TENM3/CDH1/ITGB1/DSC3/DSC2/DSG2/PLXNB2/PALLD/PCDH11X/CLSTN1/FAT1/PTPRM/OBSL1/CADM1 14 GO:0007254 JNK cascade 14/1115 167/18722 0.123854205098454 0.352294939275784 EGFR/IGF1R/HACD3/APP/RB1CC1/NCOR1/TAOK1/GSTP1/TRPV4/TAOK3/HMGB1/TLR3/DNAJA1/LTBR 14 GO:0043393 regulation of protein binding 16/1115 196/18722 0.124901783858094 0.35489655349567 LRP1/PTPRF/NRP1/APP/TGFBR3/HSP90AB1/ATP2A2/ROCK1/TGFBR1/TCF7L2/AMFR/CAV1/RAN/ACTB/ANXA2/RAPGEF2 16 GO:0045664 regulation of neuron differentiation 16/1115 196/18722 0.124901783858094 0.35489655349567 PBX1/SLC6A4/APP/ZFHX3/NRCAM/BMP7/TUG1/JAG1/ROCK1/GLI3/MIB1/ESRP1/EDNRB/REST/ISL1/RHOA 16 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 10/1115 111/18722 0.125045622792974 0.355116266006218 EGFR/FLT1/IGF1R/PLXNB1/ERBB3/FN1/PDGFD/PIK3IP1/INSR/CAT 10 GO:0019985 translesion synthesis 3/1115 21/18722 0.126256284212268 0.356468694558063 REV3L/USP10/USP43 3 GO:0032288 myelin assembly 3/1115 21/18722 0.126256284212268 0.356468694558063 ITGB4/DICER1/GPC1 3 GO:0035330 regulation of hippo signaling 3/1115 21/18722 0.126256284212268 0.356468694558063 DLG5/WWC2/MAPK14 3 GO:0048745 smooth muscle tissue development 3/1115 21/18722 0.126256284212268 0.356468694558063 NF1/DLG1/PKD2 3 GO:0071605 monocyte chemotactic protein-1 production 3/1115 21/18722 0.126256284212268 0.356468694558063 GSTP1/TRPV4/HMGB1 3 GO:0071637 regulation of monocyte chemotactic protein-1 production 3/1115 21/18722 0.126256284212268 0.356468694558063 GSTP1/TRPV4/HMGB1 3 GO:0090026 positive regulation of monocyte chemotaxis 3/1115 21/18722 0.126256284212268 0.356468694558063 LGMN/ANO6/HMGB1 3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/1115 21/18722 0.126256284212268 0.356468694558063 MIF/CD74/RRM2B 3 GO:1902473 regulation of protein localization to synapse 3/1115 21/18722 0.126256284212268 0.356468694558063 DAG1/ADAM10/DLG1 3 GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 3/1115 21/18722 0.126256284212268 0.356468694558063 SLC22A5/SLC22A18/ATP7B 3 GO:2000291 regulation of myoblast proliferation 3/1115 21/18722 0.126256284212268 0.356468694558063 MALAT1/MEIS2/ZNF609 3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 5/1115 45/18722 0.127799518612813 0.359874277359605 PPIA/ARL6IP5/P4HB/HSPB1/SOD1 5 GO:0042551 neuron maturation 5/1115 45/18722 0.127799518612813 0.359874277359605 APP/NRCAM/B4GALT5/CLN5/EDNRB 5 GO:0060119 inner ear receptor cell development 5/1115 45/18722 0.127799518612813 0.359874277359605 TRIP11/MYO7A/NAGLU/TSKU/SOD1 5 GO:0060421 positive regulation of heart growth 5/1115 45/18722 0.127799518612813 0.359874277359605 TGFBR3/RBPJ/MAPK14/BMPR1A/FGFR2 5 GO:1904646 cellular response to amyloid-beta 5/1115 45/18722 0.127799518612813 0.359874277359605 LRP1/IGF1R/LGMN/APP/GJA1 5 GO:1902806 regulation of cell cycle G1/S phase transition 14/1115 168/18722 0.128164469376433 0.36071170374316 EGFR/ANXA1/ATP2B4/PRKDC/RPL26/DLG1/ADAMTS1/ADAM17/JADE1/CCND1/APPL1/PKD2/ANKRD17/ATM 14 GO:1901987 regulation of cell cycle phase transition 29/1115 390/18722 0.128524900359506 0.361535533729929 EGFR/ANXA1/PBX1/NPM1/APP/ATP2B4/ZFP36L1/BRD4/PRKDC/TPR/USP47/RPL26/TAOK1/DLG1/DDB1/ADAMTS1/ADAM17/TAOK3/JADE1/MAPK14/CCND1/ZNF207/FEM1B/APPL1/PKD2/ANKRD17/FOXO4/ATM/UBE2C 29 GO:0071230 cellular response to amino acid stimulus 7/1115 71/18722 0.129026162195691 0.362754439158923 COL4A1/DNMT3A/SLC38A9/COL5A2/CPEB4/PDGFD/HNRNPD 7 GO:0043502 regulation of muscle adaptation 9/1115 98/18722 0.129230463362435 0.362897034571997 DAG1/IL6ST/ATP2B4/P2RX4/SLC9A1/ATP2A2/ROCK1/JARID2/PPP3CA 9 GO:1902882 regulation of response to oxidative stress 9/1115 98/18722 0.129230463362435 0.362897034571997 MET/PPIA/BMP7/P4HB/HSPB1/OXR1/REST/CTNNB1/SOD1 9 GO:0044270 cellular nitrogen compound catabolic process 33/1115 451/18722 0.129280794110496 0.362897034571997 NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/TET2/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/PDE10A/PDE7A/TDG/RC3H1/ATM/MGAT1/HSPA1A/HNRNPD/SND1/FUS/YBX3 33 GO:0007405 neuroblast proliferation 6/1115 58/18722 0.129826611254071 0.363350262879811 NF1/PLXNB2/GLI3/FGFR2/FZD3/CTNNB1 6 GO:0043506 regulation of JUN kinase activity 6/1115 58/18722 0.129826611254071 0.363350262879811 RPS3/GSTP1/FZD5/DVL3/TAOK3/DNAJA1 6 GO:1902808 positive regulation of cell cycle G1/S phase transition 6/1115 58/18722 0.129826611254071 0.363350262879811 EGFR/ANXA1/ADAMTS1/ADAM17/CCND1/ANKRD17 6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/1115 58/18722 0.129826611254071 0.363350262879811 RPS3/RPL26/SERINC3/CAV1/EIF5A/SOD1 6 GO:0043523 regulation of neuron apoptotic process 17/1115 212/18722 0.13069009445842 0.363350262879811 LRP1/GRN/NRP1/LGMN/NF1/ERBB3/HSP90AB1/RASA1/PRKCI/CPEB4/CLN3/OXR1/ISL1/CTNNB1/WFS1/RHOA/SOD1 17 GO:2001235 positive regulation of apoptotic signaling pathway 11/1115 126/18722 0.130720404623339 0.363350262879811 CTSC/MAGED1/RPS3/RPL26/SERINC3/TGFBR1/PDIA3/CAV1/EIF5A/LTBR/SOD1 11 GO:0001975 response to amphetamine 4/1115 33/18722 0.130735316537201 0.363350262879811 CALM1/RANBP2/PPP3CA/SOD1 4 GO:0003382 epithelial cell morphogenesis 4/1115 33/18722 0.130735316537201 0.363350262879811 MET/ST14/PALLD/FAT1 4 GO:0010165 response to X-ray 4/1115 33/18722 0.130735316537201 0.363350262879811 ANXA1/NIPBL/CCND1/ATM 4 GO:0034110 regulation of homotypic cell-cell adhesion 4/1115 33/18722 0.130735316537201 0.363350262879811 IL6ST/ANK3/F11R/C1QTNF1 4 GO:0035025 positive regulation of Rho protein signal transduction 4/1115 33/18722 0.130735316537201 0.363350262879811 ADGRG1/NET1/AKAP13/F11R 4 GO:0042558 pteridine-containing compound metabolic process 4/1115 33/18722 0.130735316537201 0.363350262879811 SLC19A1/FOLR1/MTR/GGH 4 GO:0046685 response to arsenic-containing substance 4/1115 33/18722 0.130735316537201 0.363350262879811 HNRNPA1/SLC38A2/SERPINF1/DHX36 4 GO:0060122 inner ear receptor cell stereocilium organization 4/1115 33/18722 0.130735316537201 0.363350262879811 TRIP11/MYO7A/TSKU/SOD1 4 GO:0150117 positive regulation of cell-substrate junction organization 4/1115 33/18722 0.130735316537201 0.363350262879811 IQGAP1/NRP1/ROCK1/S100A10 4 GO:1902692 regulation of neuroblast proliferation 4/1115 33/18722 0.130735316537201 0.363350262879811 NF1/GLI3/FZD3/CTNNB1 4 GO:1903146 regulation of autophagy of mitochondrion 4/1115 33/18722 0.130735316537201 0.363350262879811 VPS13C/FZD5/VDAC1/SREBF2 4 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/1115 33/18722 0.130735316537201 0.363350262879811 NR2F2/LATS2/IPO7/CDKN1C 4 GO:2000036 regulation of stem cell population maintenance 4/1115 33/18722 0.130735316537201 0.363350262879811 NCOA3/BMP7/ZC3H13/REST 4 GO:0031099 regeneration 16/1115 198/18722 0.132937332279825 0.366578548214145 EGFR/LRP1/DAG1/GRN/ANXA1/PTPRF/RPS16/TGFBR3/FOLR1/GSTP1/MTR/GLI3/CFLAR/CCND1/PPP3CA/ISL1 16 GO:0006816 calcium ion transport 31/1115 422/18722 0.133186281328194 0.366578548214145 AHNAK/TPT1/ATP2B1/ITGAV/ATP2B4/GJA1/CALM1/ANO6/P2RX4/ITPR2/MCOLN3/YWHAE/SLC9A1/ATP2A2/C4orf3/SEC61A1/KCNN4/TMEM37/TRPM7/VDAC1/DMD/TRPV4/CAV1/PKD2/PPP3CA/IBTK/ANXA2/VMP1/CTNNB1/WFS1/RHOA 31 GO:0007519 skeletal muscle tissue development 13/1115 155/18722 0.134056705402393 0.366578548214145 PLEC/DDX17/GPC1/NR2F2/DMD/MAPK14/CFLAR/CAV1/MYL6/PPP3CA/CTNNB1/RHOA/YBX3 13 GO:0007051 spindle organization 15/1115 184/18722 0.135068761401362 0.366578548214145 ATRX/TACC2/RPS3/TPR/CLTC/NCOR1/DLG1/DYNC1H1/KPNB1/SENP6/RAN/ZNF207/CDC20/HSPA1A/RHOA 15 GO:0055001 muscle cell development 15/1115 184/18722 0.135068761401362 0.366578548214145 KRT19/ITGB1/KRT8/ACTG1/PLEC/ATP2A2/ACTN4/AKAP13/DMD/CFLAR/MYOF/BMPR1A/OBSL1/PPP3CA/ISL1 15 GO:0140014 mitotic nuclear division 22/1115 287/18722 0.135119482677702 0.366578548214145 LRP5/NIPBL/ATRX/BMP7/TPR/RPL24/EML4/PHIP/KPNB1/PDS5B/RANBP1/RAN/ZNF207/OBSL1/INSR/CDK13/ATM/UBE2C/NUSAP1/CDC20/HSPA1A/RHOA 22 GO:0003300 cardiac muscle hypertrophy 9/1115 99/18722 0.135131257146659 0.366578548214145 IL6ST/ATP2B4/P2RX4/SLC9A1/ATP2A2/AKAP13/ROCK1/JARID2/PPP3CA 9 GO:0010717 regulation of epithelial to mesenchymal transition 9/1115 99/18722 0.135131257146659 0.366578548214145 DAG1/GCNT2/BMP7/JAG1/TGFBR1/TCF7L2/SMAD2/ISL1/CTNNB1 9 GO:0016241 regulation of macroautophagy 12/1115 141/18722 0.13521546946547 0.366578548214145 GAPDH/ATP6V1B1/VPS13C/SMG1/VDAC1/NPC1/C9orf72/RAB3GAP1/CLN3/RAB3GAP2/ATP6V0A1/TRIM13 12 GO:0014743 regulation of muscle hypertrophy 7/1115 72/18722 0.13605552042858 0.366578548214145 IL6ST/ATP2B4/P2RX4/SLC9A1/ROCK1/JARID2/PPP3CA 7 GO:0001731 formation of translation preinitiation complex 2/1115 11/18722 0.136497125650819 0.366578548214145 RPL13A/EIF2S2 2 GO:0001967 suckling behavior 2/1115 11/18722 0.136497125650819 0.366578548214145 APP/UBR3 2 GO:0002327 immature B cell differentiation 2/1115 11/18722 0.136497125650819 0.366578548214145 IRF2BP2/ATM 2 GO:0002732 positive regulation of dendritic cell cytokine production 2/1115 11/18722 0.136497125650819 0.366578548214145 DHX36/MAVS 2 GO:0003093 regulation of glomerular filtration 2/1115 11/18722 0.136497125650819 0.366578548214145 GJA1/GJA5 2 GO:0003263 cardioblast proliferation 2/1115 11/18722 0.136497125650819 0.366578548214145 ISL1/CTNNB1 2 GO:0003264 regulation of cardioblast proliferation 2/1115 11/18722 0.136497125650819 0.366578548214145 ISL1/CTNNB1 2 GO:0006020 inositol metabolic process 2/1115 11/18722 0.136497125650819 0.366578548214145 SLC5A3/ISYNA1 2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 2/1115 11/18722 0.136497125650819 0.366578548214145 CYCS/UQCRH 2 GO:0009235 cobalamin metabolic process 2/1115 11/18722 0.136497125650819 0.366578548214145 LMBRD1/MTR 2 GO:0014854 response to inactivity 2/1115 11/18722 0.136497125650819 0.366578548214145 DAG1/CAT 2 GO:0018342 protein prenylation 2/1115 11/18722 0.136497125650819 0.366578548214145 CHML/PTAR1 2 GO:0021860 pyramidal neuron development 2/1115 11/18722 0.136497125650819 0.366578548214145 SCYL2/FGFR2 2 GO:0032351 negative regulation of hormone metabolic process 2/1115 11/18722 0.136497125650819 0.366578548214145 ATP1A1/REST 2 GO:0033197 response to vitamin E 2/1115 11/18722 0.136497125650819 0.366578548214145 CCND1/CAT 2 GO:0033327 Leydig cell differentiation 2/1115 11/18722 0.136497125650819 0.366578548214145 SF1/CCND1 2 GO:0033483 gas homeostasis 2/1115 11/18722 0.136497125650819 0.366578548214145 GSTP1/CAV1 2 GO:0033632 regulation of cell-cell adhesion mediated by integrin 2/1115 11/18722 0.136497125650819 0.366578548214145 DPP4/WNK1 2 GO:0033690 positive regulation of osteoblast proliferation 2/1115 11/18722 0.136497125650819 0.366578548214145 ITGAV/LRP5 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/1115 11/18722 0.136497125650819 0.366578548214145 RTN4/HMGB1 2 GO:0034379 very-low-density lipoprotein particle assembly 2/1115 11/18722 0.136497125650819 0.366578548214145 ACSL3/LPCAT3 2 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 2/1115 11/18722 0.136497125650819 0.366578548214145 DNAJC3/PPP1R15B 2 GO:0043589 skin morphogenesis 2/1115 11/18722 0.136497125650819 0.366578548214145 ITGA6/ITGB4 2 GO:0044068 modulation by symbiont of host cellular process 2/1115 11/18722 0.136497125650819 0.366578548214145 ANO6/SERPINB9 2 GO:0045060 negative thymic T cell selection 2/1115 11/18722 0.136497125650819 0.366578548214145 CD74/GLI3 2 GO:0045657 positive regulation of monocyte differentiation 2/1115 11/18722 0.136497125650819 0.366578548214145 ZFP36L1/CD74 2 GO:0048096 chromatin-mediated maintenance of transcription 2/1115 11/18722 0.136497125650819 0.366578548214145 ARID1A/SERTAD2 2 GO:0048680 positive regulation of axon regeneration 2/1115 11/18722 0.136497125650819 0.366578548214145 LRP1/GRN 2 GO:0048715 negative regulation of oligodendrocyte differentiation 2/1115 11/18722 0.136497125650819 0.366578548214145 NF1/CTNNB1 2 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 2/1115 11/18722 0.136497125650819 0.366578548214145 ZDHHC17/CYFIP2 2 GO:0051574 positive regulation of histone H3-K9 methylation 2/1115 11/18722 0.136497125650819 0.366578548214145 RIF1/JARID2 2 GO:0051657 maintenance of organelle location 2/1115 11/18722 0.136497125650819 0.366578548214145 AKAP9/ARHGAP21 2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 2/1115 11/18722 0.136497125650819 0.366578548214145 CALM1/PKD2 2 GO:0060767 epithelial cell proliferation involved in prostate gland development 2/1115 11/18722 0.136497125650819 0.366578548214145 SERPINF1/CTNNB1 2 GO:0060837 blood vessel endothelial cell differentiation 2/1115 11/18722 0.136497125650819 0.366578548214145 NRP1/RBPJ 2 GO:0070417 cellular response to cold 2/1115 11/18722 0.136497125650819 0.366578548214145 SLC9A1/DNAJC3 2 GO:0070778 L-aspartate transmembrane transport 2/1115 11/18722 0.136497125650819 0.366578548214145 SLC1A5/SLC1A3 2 GO:0071492 cellular response to UV-A 2/1115 11/18722 0.136497125650819 0.366578548214145 MME/OPN3 2 GO:0071609 chemokine (C-C motif) ligand 5 production 2/1115 11/18722 0.136497125650819 0.366578548214145 TRPV4/MAVS 2 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 2/1115 11/18722 0.136497125650819 0.366578548214145 TRPV4/MAVS 2 GO:0072017 distal tubule development 2/1115 11/18722 0.136497125650819 0.366578548214145 JAG1/PKD2 2 GO:0075522 IRES-dependent viral translational initiation 2/1115 11/18722 0.136497125650819 0.366578548214145 PCBP2/EIF3A 2 GO:0090030 regulation of steroid hormone biosynthetic process 2/1115 11/18722 0.136497125650819 0.366578548214145 ATP1A1/REST 2 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 2/1115 11/18722 0.136497125650819 0.366578548214145 DVL3/PTK7 2 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 2/1115 11/18722 0.136497125650819 0.366578548214145 MPHOSPH8/ATF7IP 2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 2/1115 11/18722 0.136497125650819 0.366578548214145 SLC35D1/SLC35B4 2 GO:0097354 prenylation 2/1115 11/18722 0.136497125650819 0.366578548214145 CHML/PTAR1 2 GO:0098935 dendritic transport 2/1115 11/18722 0.136497125650819 0.366578548214145 KIF5B/TRAK2 2 GO:0106049 regulation of cellular response to osmotic stress 2/1115 11/18722 0.136497125650819 0.366578548214145 CLN3/YBX3 2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 2/1115 11/18722 0.136497125650819 0.366578548214145 CALM1/CAV1 2 GO:1902667 regulation of axon guidance 2/1115 11/18722 0.136497125650819 0.366578548214145 NRP1/MYCBP2 2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 2/1115 11/18722 0.136497125650819 0.366578548214145 ADAM17/HSPA1A 2 GO:1903961 positive regulation of anion transmembrane transport 2/1115 11/18722 0.136497125650819 0.366578548214145 TCAF1/ITGB1 2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/1115 11/18722 0.136497125650819 0.366578548214145 ATF6/HSPA5 2 GO:2000615 regulation of histone H3-K9 acetylation 2/1115 11/18722 0.136497125650819 0.366578548214145 ZNF451/KMT2A 2 GO:2000644 regulation of receptor catabolic process 2/1115 11/18722 0.136497125650819 0.366578548214145 FURIN/ANXA2 2 GO:2000786 positive regulation of autophagosome assembly 2/1115 11/18722 0.136497125650819 0.366578548214145 RAB3GAP1/RAB3GAP2 2 GO:0031057 negative regulation of histone modification 5/1115 46/18722 0.13680131822173 0.367210778273412 UBR5/ZNF451/KDM5A/TRIP12/JARID2 5 GO:0006406 mRNA export from nucleus 6/1115 59/18722 0.137717267298935 0.368557639152389 TPR/SRSF3/SMG1/THOC2/SETD2/HNRNPA2B1 6 GO:0021885 forebrain cell migration 6/1115 59/18722 0.137717267298935 0.368557639152389 ADGRG1/LAMB1/RTN4/GLI3/CTNNB1/RHOA 6 GO:0030042 actin filament depolymerization 6/1115 59/18722 0.137717267298935 0.368557639152389 CFL1/SCIN/SPTBN1/ADD3/SPTAN1/DSTN 6 GO:0032768 regulation of monooxygenase activity 6/1115 59/18722 0.137717267298935 0.368557639152389 EGFR/ATP2B4/CALM1/CAV1/ZDHHC21/HM13 6 GO:0043407 negative regulation of MAP kinase activity 6/1115 59/18722 0.137717267298935 0.368557639152389 NF1/BMP7/GSTP1/SMPD1/CAV1/DNAJA1 6 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 6/1115 59/18722 0.137717267298935 0.368557639152389 TPR/SRSF3/SMG1/THOC2/SETD2/HNRNPA2B1 6 GO:0071695 anatomical structure maturation 18/1115 229/18722 0.139835830696699 0.372425280440955 DAG1/APP/PLXNB1/NRCAM/B4GALT5/FZD5/FERMT1/CLN5/RBPJ/PTBP3/TFCP2L1/FEM1B/EDNRB/ANKRD17/RERE/CTNNB1/GPAT4/RHOA 18 GO:0006907 pinocytosis 3/1115 22/18722 0.140069294460655 0.372425280440955 CLN3/CAV1/APPL1 3 GO:0007413 axonal fasciculation 3/1115 22/18722 0.140069294460655 0.372425280440955 NRP1/RTN4/NRCAM 3 GO:0021854 hypothalamus development 3/1115 22/18722 0.140069294460655 0.372425280440955 NRP2/NRP1/RAB3GAP1 3 GO:0032891 negative regulation of organic acid transport 3/1115 22/18722 0.140069294460655 0.372425280440955 SLC43A2/ARL6IP5/PLA2R1 3 GO:0034629 cellular protein-containing complex localization 3/1115 22/18722 0.140069294460655 0.372425280440955 AKAP9/DLG1/WASL 3 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 3/1115 22/18722 0.140069294460655 0.372425280440955 ANXA1/HMGB1/RC3H1 3 GO:0046058 cAMP metabolic process 3/1115 22/18722 0.140069294460655 0.372425280440955 ADCY7/PDE10A/PDE7A 3 GO:0051151 negative regulation of smooth muscle cell differentiation 3/1115 22/18722 0.140069294460655 0.372425280440955 NFATC3/ANKRD17/FOXO4 3 GO:0051412 response to corticosterone 3/1115 22/18722 0.140069294460655 0.372425280440955 ATP2B1/CALM1/CCND1 3 GO:0060343 trabecula formation 3/1115 22/18722 0.140069294460655 0.372425280440955 FBN2/TGFBR3/ADAMTS1 3 GO:0106030 neuron projection fasciculation 3/1115 22/18722 0.140069294460655 0.372425280440955 NRP1/RTN4/NRCAM 3 GO:0140467 integrated stress response signaling 3/1115 22/18722 0.140069294460655 0.372425280440955 HSPA5/TMEM33/PPP1R15B 3 GO:0072503 cellular divalent inorganic cation homeostasis 35/1115 486/18722 0.140954390433867 0.374291230238338 TPT1/LRP1/ATP2B1/ITGAV/HSP90B1/SLC39A10/APP/ATP2B4/ATP13A3/GJA1/CALM1/HEXB/P2RX4/ITPR2/MCOLN3/YWHAE/ATP2A2/GRINA/SLC30A7/GTF2I/TRPM7/DMD/TMEM64/TRPV4/CCDC47/C1QTNF1/CLN3/HMGB1/CAV1/S1PR3/EDNRB/PKD2/IBTK/ATP7B/WFS1 35 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11/1115 128/18722 0.141210846714382 0.374291230238338 APP/ARL6IP5/RB1CC1/TAOK1/RNF13/TRPV4/TAOK3/EMC10/HMGB1/TLR3/LTBR 11 GO:0002183 cytoplasmic translational initiation 4/1115 34/18722 0.141612205322863 0.374291230238338 RPL13A/EIF3A/EIF2S2/EIF3H 4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 4/1115 34/18722 0.141612205322863 0.374291230238338 LGMN/CD74/CTSD/CTSF 4 GO:0007095 mitotic G2 DNA damage checkpoint signaling 4/1115 34/18722 0.141612205322863 0.374291230238338 TAOK1/TAOK3/FOXO4/ATM 4 GO:0035909 aorta morphogenesis 4/1115 34/18722 0.141612205322863 0.374291230238338 LRP1/JAG1/RBPJ/BMPR1A 4 GO:0044319 wound healing, spreading of cells 4/1115 34/18722 0.141612205322863 0.374291230238338 FERMT1/ADAM17/DDR1/RHOA 4 GO:0051973 positive regulation of telomerase activity 4/1115 34/18722 0.141612205322863 0.374291230238338 PTGES3/HSP90AB1/PKIB/CTNNB1 4 GO:0090075 relaxation of muscle 4/1115 34/18722 0.141612205322863 0.374291230238338 P2RX4/ATP2A2/ATP1A1/SOD1 4 GO:0090505 epiboly involved in wound healing 4/1115 34/18722 0.141612205322863 0.374291230238338 FERMT1/ADAM17/DDR1/RHOA 4 GO:1990000 amyloid fibril formation 4/1115 34/18722 0.141612205322863 0.374291230238338 APP/FURIN/USP9X/SIAH2 4 GO:0051261 protein depolymerization 10/1115 114/18722 0.141612340341158 0.374291230238338 CFL1/SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/TRPV4/DNAJC6/CAMSAP2/DSTN 10 GO:0051145 smooth muscle cell differentiation 7/1115 73/18722 0.143268330691588 0.378480760792868 PIAS1/NFATC3/EDNRB/FGFR2/ANKRD17/FOXO4/CTNNB1 7 GO:1902600 proton transmembrane transport 13/1115 157/18722 0.143592679056746 0.379150006668629 COX6A1/SLC17A5/ATP6V1B1/SLC11A2/SLC9A1/ACTN4/ATP6AP1/CLCN3/ATP1A1/TMSB4X/SLC22A18/ATP6V0A1/UQCRH 13 GO:1903131 mononuclear cell differentiation 31/1115 426/18722 0.1445485851063 0.381485366229626 CD46/ITGB1/ANXA1/CDK6/PBX1/ITGB8/RPS6/ZFP36L1/CD74/PRKDC/HECTD1/FZD5/RBPJ/ADAM17/GLI3/FOXP1/HMGB1/IRF2BP2/PTPRK/ITGB6/CLPTM1/ITFG2/RC3H1/ATM/ERBB2/MR1/CTNNB1/FASN/LTBR/RHOA/SOD1 31 GO:0009416 response to light stimulus 24/1115 320/18722 0.145390374214623 0.383517395223257 EGFR/ITGB1/MME/NPM1/APP/NF1/CDS1/USP47/GNAQ/RPL26/DDB1/MEIS2/SLC1A3/SMPD1/TP53I13/PIAS1/DHX36/SCARA3/PTPRK/OPN3/CCND1/UBE4B/CAT/CREBBP 24 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 5/1115 47/18722 0.146074459901898 0.383616104976013 SPPL2A/GSTP1/ADAM17/SPPL2B/HSPA1A 5 GO:0031641 regulation of myelination 5/1115 47/18722 0.146074459901898 0.383616104976013 DAG1/DICER1/CTSC/DLG1/CTNNB1 5 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 5/1115 47/18722 0.146074459901898 0.383616104976013 ATF6/HSPA5/RBPJ/CHD6/HSPA1A 5 GO:0048512 circadian behavior 5/1115 47/18722 0.146074459901898 0.383616104976013 ADRB1/ZFHX3/NCOR1/NAGLU/NCOA2 5 GO:0051489 regulation of filopodium assembly 5/1115 47/18722 0.146074459901898 0.383616104976013 NRP1/TGFBR1/PPP1R9A/WASL/CLN3 5 GO:0061001 regulation of dendritic spine morphogenesis 5/1115 47/18722 0.146074459901898 0.383616104976013 CFL1/ADAM10/PPP1R9A/DHX36/ABI2 5 GO:0097028 dendritic cell differentiation 5/1115 47/18722 0.146074459901898 0.383616104976013 ITGB8/RBPJ/HMGB1/ITGB6/LTBR 5 GO:0120163 negative regulation of cold-induced thermogenesis 5/1115 47/18722 0.146074459901898 0.383616104976013 LGR4/LNPEP/RBPJ/ADAM17/ACVR2B 5 GO:1903170 negative regulation of calcium ion transmembrane transport 5/1115 47/18722 0.146074459901898 0.383616104976013 CALM1/YWHAE/C4orf3/VDAC1/PKD2 5 GO:1901879 regulation of protein depolymerization 8/1115 87/18722 0.146161724537899 0.383656562098251 SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/TRPV4/CAMSAP2/DSTN 8 GO:0098869 cellular oxidant detoxification 9/1115 101/18722 0.147343104186137 0.38656748562643 PRDX1/BMP7/PRDX4/GPX3/GSTP1/GPX8/CAT/PRDX3/SOD1 9 GO:0016236 macroautophagy 22/1115 291/18722 0.149156524540138 0.391132949174752 GAPDH/CALM1/ATP6V1B1/VPS13C/RB1CC1/SMG1/ATP2A2/SNX14/UFL1/LAMP2/VDAC1/NPC1/C9orf72/TMEM41B/RAB3GAP1/WDFY3/CLN3/RAB3GAP2/ATG9A/ATP6V0A1/VMP1/TRIM13 22 GO:0007612 learning 12/1115 144/18722 0.150493520095878 0.394251670162852 ITGB1/LGMN/APP/NF1/VDAC1/MEIS2/TPBG/PIAS1/CLN3/INSR/UBA6/ARF4 12 GO:0033135 regulation of peptidyl-serine phosphorylation 12/1115 144/18722 0.150493520095878 0.394251670162852 EGFR/AKAP9/APP/ATP2B4/MIF/HSP90AB1/NSD1/TFRC/RICTOR/GPD1L/DMD/CAV1 12 GO:0009615 response to virus 27/1115 367/18722 0.15062298622585 0.394397314104861 TPT1/CDK6/ITGB8/CFL1/DDX17/IL10RB/ENO1/PCBP2/SERINC3/TRIM56/IFI6/SMPD1/TRIM44/PUM2/SKP2/DNAJC3/HSPB1/DHX36/SETD2/PUM1/MAPK14/ITGB6/TLR3/MOV10/ANKRD17/EIF5A/MAVS 27 GO:0070374 positive regulation of ERK1 and ERK2 cascade 17/1115 217/18722 0.151038260007292 0.395290818715163 EGFR/LRP1/NRP1/APP/MIF/CD74/GCNT2/ATP6AP1/TPBG/TRPV4/HMGB1/SEMA7A/PDGFD/CFLAR/GAREM1/FGFR2/RAPGEF2 17 GO:0015918 sterol transport 11/1115 130/18722 0.152132367386562 0.395996997273945 LRP1/ABCA1/FURIN/SYT7/NPC1/OSBPL8/TSKU/CAV1/SREBF2/LPCAT3/ANXA2 11 GO:0043467 regulation of generation of precursor metabolites and energy 11/1115 130/18722 0.152132367386562 0.395996997273945 APP/IL10RB/NCOR1/CHCHD2/EPM2AIP1/SORBS1/TRPV4/HMGB1/OPN3/INSR/RHOA 11 GO:0006298 mismatch repair 4/1115 35/18722 0.152832489034869 0.395996997273945 SETD2/HMGB1/TDG/MLH3 4 GO:0039694 viral RNA genome replication 4/1115 35/18722 0.152832489034869 0.395996997273945 EEA1/PCBP2/MPHOSPH8/TOP2B 4 GO:0040001 establishment of mitotic spindle localization 4/1115 35/18722 0.152832489034869 0.395996997273945 ITGB1/GJA1/KPNB1/NUSAP1 4 GO:0042462 eye photoreceptor cell development 4/1115 35/18722 0.152832489034869 0.395996997273945 TUG1/PRKCI/MYO7A/NAGLU 4 GO:0050654 chondroitin sulfate proteoglycan metabolic process 4/1115 35/18722 0.152832489034869 0.395996997273945 CHPF/DSE/CHST11/B3GAT3 4 GO:0060236 regulation of mitotic spindle organization 4/1115 35/18722 0.152832489034869 0.395996997273945 TPR/CLTC/DYNC1H1/HSPA1A 4 GO:0090504 epiboly 4/1115 35/18722 0.152832489034869 0.395996997273945 FERMT1/ADAM17/DDR1/RHOA 4 GO:0097421 liver regeneration 4/1115 35/18722 0.152832489034869 0.395996997273945 EGFR/RPS16/GLI3/CCND1 4 GO:0030308 negative regulation of cell growth 15/1115 188/18722 0.152859741626085 0.395996997273945 SEMA6D/NRP1/SEMA6A/RTN4/SEMA3F/GJA1/SMARCA2/ENO1/RYK/SEMA4B/SERTAD2/BMPR2/JADE1/SEMA7A/HSPA1A 15 GO:0033559 unsaturated fatty acid metabolic process 10/1115 116/18722 0.153258912696205 0.395996997273945 ANXA1/MIF/CD74/PTGES3/ATP6V1B1/GSTP1/DEGS1/ACOX1/ELOVL1/HPGD 10 GO:0043200 response to amino acid 10/1115 116/18722 0.153258912696205 0.395996997273945 COL4A1/DNMT3A/SLC38A9/GSTP1/COL5A2/UFL1/CPEB4/PDGFD/HNRNPD/RHOA 10 GO:0014897 striated muscle hypertrophy 9/1115 102/18722 0.153649492084703 0.395996997273945 IL6ST/ATP2B4/P2RX4/SLC9A1/ATP2A2/AKAP13/ROCK1/JARID2/PPP3CA 9 GO:0006900 vesicle budding from membrane 6/1115 61/18722 0.154146710617321 0.395996997273945 SEC31A/PRKCI/S100A10/MIA3/WASL/ANXA2 6 GO:0030199 collagen fibril organization 6/1115 61/18722 0.154146710617321 0.395996997273945 COL14A1/NF1/COL5A2/TGFBR1/CRTAP/ANXA2 6 GO:0060997 dendritic spine morphogenesis 6/1115 61/18722 0.154146710617321 0.395996997273945 CFL1/ADAM10/PPP1R9A/WASL/DHX36/ABI2 6 GO:0060998 regulation of dendritic spine development 6/1115 61/18722 0.154146710617321 0.395996997273945 CDKL5/DLG5/PPP1R9A/DHX36/ASAP1/C21orf91 6 GO:0090342 regulation of cell aging 6/1115 61/18722 0.154146710617321 0.395996997273945 CDK6/MIF/PRKDC/YBX1/AKT3/BMPR1A 6 GO:0055074 calcium ion homeostasis 33/1115 460/18722 0.154237756986104 0.395996997273945 TPT1/LRP1/ATP2B1/ITGAV/HSP90B1/APP/ATP2B4/ATP13A3/GJA1/CALM1/HEXB/P2RX4/ATP6V1B1/ITPR2/MCOLN3/YWHAE/ATP2A2/GRINA/GTF2I/DMD/TMEM64/TRPV4/CCDC47/C1QTNF1/CLN3/HMGB1/CAV1/S1PR3/EDNRB/PKD2/IBTK/ATP7B/WFS1 33 GO:0002052 positive regulation of neuroblast proliferation 3/1115 23/18722 0.154360072357634 0.395996997273945 GLI3/FZD3/CTNNB1 3 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3/1115 23/18722 0.154360072357634 0.395996997273945 MME/ENPEP/RHOA 3 GO:0010888 negative regulation of lipid storage 3/1115 23/18722 0.154360072357634 0.395996997273945 ITGAV/ABCA1/OSBPL8 3 GO:0019430 removal of superoxide radicals 3/1115 23/18722 0.154360072357634 0.395996997273945 PRDX1/BMP7/SOD1 3 GO:0030539 male genitalia development 3/1115 23/18722 0.154360072357634 0.395996997273945 LGR4/DHCR24/CTNNB1 3 GO:0031338 regulation of vesicle fusion 3/1115 23/18722 0.154360072357634 0.395996997273945 ANXA1/KIF5B/ANXA2 3 GO:0033081 regulation of T cell differentiation in thymus 3/1115 23/18722 0.154360072357634 0.395996997273945 CLPTM1/ERBB2/SOD1 3 GO:0040019 positive regulation of embryonic development 3/1115 23/18722 0.154360072357634 0.395996997273945 CFL1/B4GALT5/AMOT 3 GO:0042438 melanin biosynthetic process 3/1115 23/18722 0.154360072357634 0.395996997273945 OPN3/APPL1/RAPGEF2 3 GO:0046618 xenobiotic export 3/1115 23/18722 0.154360072357634 0.395996997273945 SLC22A5/SLC22A18/ATP7B 3 GO:0050765 negative regulation of phagocytosis 3/1115 23/18722 0.154360072357634 0.395996997273945 CD47/HMGB1/APPL1 3 GO:0051131 chaperone-mediated protein complex assembly 3/1115 23/18722 0.154360072357634 0.395996997273945 PTGES3/HSP90AB1/HSPA1A 3 GO:0090335 regulation of brown fat cell differentiation 3/1115 23/18722 0.154360072357634 0.395996997273945 BMP7/TRPV4/MAPK14 3 GO:1900273 positive regulation of long-term synaptic potentiation 3/1115 23/18722 0.154360072357634 0.395996997273945 MME/LGMN/APP 3 GO:0042149 cellular response to glucose starvation 5/1115 48/18722 0.155607772662736 0.395996997273945 HNRNPA1/SLC2A1/HSPA5/CPEB4/ITFG2 5 GO:0097720 calcineurin-mediated signaling 5/1115 48/18722 0.155607772662736 0.395996997273945 ATP2B4/NFAT5/SLC9A1/NFATC3/PPP3CA 5 GO:1903053 regulation of extracellular matrix organization 5/1115 48/18722 0.155607772662736 0.395996997273945 LRP1/DAG1/DPP4/DDR1/CFLAR 5 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 5/1115 48/18722 0.155607772662736 0.395996997273945 RPL23/RPL5/HSP90AB1/SMARCC1/EIF3H 5 GO:0001659 temperature homeostasis 14/1115 174/18722 0.155772973441192 0.395996997273945 LGR4/IGF1R/PRLR/ADRB1/GJA1/ESRRG/LNPEP/DYNC1H1/RBPJ/ADAM17/CPT2/CAV1/EDNRB/ACVR2B 14 GO:0002024 diet induced thermogenesis 2/1115 12/18722 0.157612590224224 0.395996997273945 ADRB1/TRPV4 2 GO:0002424 T cell mediated immune response to tumor cell 2/1115 12/18722 0.157612590224224 0.395996997273945 HMGB1/MR1 2 GO:0002674 negative regulation of acute inflammatory response 2/1115 12/18722 0.157612590224224 0.395996997273945 ASH1L/GSTP1 2 GO:0003306 Wnt signaling pathway involved in heart development 2/1115 12/18722 0.157612590224224 0.395996997273945 RBPJ/CTNNB1 2 GO:0010587 miRNA catabolic process 2/1115 12/18722 0.157612590224224 0.395996997273945 KCNQ1OT1/SND1 2 GO:0015780 nucleotide-sugar transmembrane transport 2/1115 12/18722 0.157612590224224 0.395996997273945 SLC35D1/SLC35B4 2 GO:0021670 lateral ventricle development 2/1115 12/18722 0.157612590224224 0.395996997273945 CDK6/TSKU 2 GO:0021978 telencephalon regionalization 2/1115 12/18722 0.157612590224224 0.395996997273945 ADGRG1/TRA2B 2 GO:0030157 pancreatic juice secretion 2/1115 12/18722 0.157612590224224 0.395996997273945 COPA/WNK1 2 GO:0032908 regulation of transforming growth factor beta1 production 2/1115 12/18722 0.157612590224224 0.395996997273945 FURIN/TSKU 2 GO:0033182 regulation of histone ubiquitination 2/1115 12/18722 0.157612590224224 0.395996997273945 UBR5/TRIP12 2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 2/1115 12/18722 0.157612590224224 0.395996997273945 CROT/ACOX1 2 GO:0034086 maintenance of sister chromatid cohesion 2/1115 12/18722 0.157612590224224 0.395996997273945 NIPBL/ATRX 2 GO:0034088 maintenance of mitotic sister chromatid cohesion 2/1115 12/18722 0.157612590224224 0.395996997273945 NIPBL/ATRX 2 GO:0035112 genitalia morphogenesis 2/1115 12/18722 0.157612590224224 0.395996997273945 NIPBL/CTNNB1 2 GO:0038180 nerve growth factor signaling pathway 2/1115 12/18722 0.157612590224224 0.395996997273945 KIDINS220/RAPGEF2 2 GO:0042117 monocyte activation 2/1115 12/18722 0.157612590224224 0.395996997273945 ADAM10/FOXP1 2 GO:0043383 negative T cell selection 2/1115 12/18722 0.157612590224224 0.395996997273945 CD74/GLI3 2 GO:0043471 regulation of cellular carbohydrate catabolic process 2/1115 12/18722 0.157612590224224 0.395996997273945 SCARB2/HMGB1 2 GO:0045117 azole transmembrane transport 2/1115 12/18722 0.157612590224224 0.395996997273945 SLC19A3/SLC28A2 2 GO:0045602 negative regulation of endothelial cell differentiation 2/1115 12/18722 0.157612590224224 0.395996997273945 JAG1/S1PR3 2 GO:0046831 regulation of RNA export from nucleus 2/1115 12/18722 0.157612590224224 0.395996997273945 TPR/SETD2 2 GO:0051001 negative regulation of nitric-oxide synthase activity 2/1115 12/18722 0.157612590224224 0.395996997273945 ATP2B4/CAV1 2 GO:0060009 Sertoli cell development 2/1115 12/18722 0.157612590224224 0.395996997273945 ATRX/RAB13 2 GO:0060019 radial glial cell differentiation 2/1115 12/18722 0.157612590224224 0.395996997273945 GLI3/RHOA 2 GO:0060601 lateral sprouting from an epithelium 2/1115 12/18722 0.157612590224224 0.395996997273945 BMP7/FGFR2 2 GO:0060907 positive regulation of macrophage cytokine production 2/1115 12/18722 0.157612590224224 0.395996997273945 CD74/SEMA7A 2 GO:0061430 bone trabecula morphogenesis 2/1115 12/18722 0.157612590224224 0.395996997273945 FBN2/PLXNB1 2 GO:0070572 positive regulation of neuron projection regeneration 2/1115 12/18722 0.157612590224224 0.395996997273945 LRP1/GRN 2 GO:0071257 cellular response to electrical stimulus 2/1115 12/18722 0.157612590224224 0.395996997273945 SLC9A1/REST 2 GO:0071287 cellular response to manganese ion 2/1115 12/18722 0.157612590224224 0.395996997273945 APP/HSPA5 2 GO:0071472 cellular response to salt stress 2/1115 12/18722 0.157612590224224 0.395996997273945 ZFP36L1/TRPV4 2 GO:0071872 cellular response to epinephrine stimulus 2/1115 12/18722 0.157612590224224 0.395996997273945 ATP2B4/SLC9A1 2 GO:0072015 glomerular visceral epithelial cell development 2/1115 12/18722 0.157612590224224 0.395996997273945 IQGAP1/JAG1 2 GO:0072376 protein activation cascade 2/1115 12/18722 0.157612590224224 0.395996997273945 FBLN1/FN1 2 GO:0072520 seminiferous tubule development 2/1115 12/18722 0.157612590224224 0.395996997273945 ADGRG1/ATRX 2 GO:0072584 caveolin-mediated endocytosis 2/1115 12/18722 0.157612590224224 0.395996997273945 CLN3/CAV1 2 GO:0072711 cellular response to hydroxyurea 2/1115 12/18722 0.157612590224224 0.395996997273945 ATRX/DDI2 2 GO:0090177 establishment of planar polarity involved in neural tube closure 2/1115 12/18722 0.157612590224224 0.395996997273945 DVL3/PTK7 2 GO:0090385 phagosome-lysosome fusion 2/1115 12/18722 0.157612590224224 0.395996997273945 SYT7/CLN3 2 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 2/1115 12/18722 0.157612590224224 0.395996997273945 C4orf3/VMP1 2 GO:1903332 regulation of protein folding 2/1115 12/18722 0.157612590224224 0.395996997273945 GRN/HSPA5 2 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 2/1115 12/18722 0.157612590224224 0.395996997273945 RYK/CTNNB1 2 GO:1905205 positive regulation of connective tissue replacement 2/1115 12/18722 0.157612590224224 0.395996997273945 ROCK1/PPP3CA 2 GO:2000628 regulation of miRNA metabolic process 2/1115 12/18722 0.157612590224224 0.395996997273945 KCNQ1OT1/RC3H1 2 GO:2001204 regulation of osteoclast development 2/1115 12/18722 0.157612590224224 0.395996997273945 FBN1/ATP6AP1 2 GO:0008088 axo-dendritic transport 7/1115 75/18722 0.158226240347211 0.397351786083612 APP/DST/DYNC1H1/KIF5B/HSPB1/TRAK2/SOD1 7 GO:0030301 cholesterol transport 10/1115 117/18722 0.159257259013072 0.399189908859526 LRP1/ABCA1/FURIN/SYT7/NPC1/TSKU/CAV1/SREBF2/LPCAT3/ANXA2 10 GO:0051225 spindle assembly 10/1115 117/18722 0.159257259013072 0.399189908859526 RPS3/TPR/NCOR1/DYNC1H1/KPNB1/SENP6/ZNF207/CDC20/HSPA1A/RHOA 10 GO:0072676 lymphocyte migration 10/1115 117/18722 0.159257259013072 0.399189908859526 APP/PLEC/DOCK8/ADAM10/ADAM17/WNK1/F11R/MIA3/WASL/RHOA 10 GO:1903828 negative regulation of cellular protein localization 10/1115 117/18722 0.159257259013072 0.399189908859526 LMAN1/MAGED1/HECTD1/CLTC/ERLEC1/FERMT1/LYPLA1/PPFIA1/LATS2/DNAJA1 10 GO:0009746 response to hexose 17/1115 219/18722 0.159638231294771 0.399957070334482 LRP1/LRP5/IGF1R/LDHA/DYNLL1/GJA1/SERPINF1/KRT18/CCDC186/TCF7L2/KIF5B/SLC29A1/SMAD2/EFNA5/PPP3CA/TRA2B/RHOA 17 GO:0046330 positive regulation of JNK cascade 8/1115 89/18722 0.15991456112106 0.400461464270798 APP/RB1CC1/TAOK1/TRPV4/TAOK3/HMGB1/TLR3/LTBR 8 GO:1905037 autophagosome organization 9/1115 103/18722 0.160086123892675 0.40070314836521 RB1CC1/ATP2A2/C9orf72/TMEM41B/RAB3GAP1/CLN3/RAB3GAP2/ATG9A/VMP1 9 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 12/1115 146/18722 0.161158916362903 0.403010517312197 ADGRG1/LGR5/LGR4/ABCA1/ADRB1/ATP2B4/GNAQ/AKAP13/ADCY7/S1PR2/S1PR3/RAPGEF2 12 GO:0010675 regulation of cellular carbohydrate metabolic process 12/1115 146/18722 0.161158916362903 0.403010517312197 RANBP2/NCOR1/SCARB2/DDB1/SLC35B4/EPM2AIP1/SORBS1/C1QTNF1/HMGB1/SOGA1/NCOA2/INSR 12 GO:0032615 interleukin-12 production 6/1115 62/18722 0.162671452471605 0.406222116345135 CD47/FOXP1/HMGB1/MAPK14/TLR3/ISL1 6 GO:0032655 regulation of interleukin-12 production 6/1115 62/18722 0.162671452471605 0.406222116345135 CD47/FOXP1/HMGB1/MAPK14/TLR3/ISL1 6 GO:0046148 pigment biosynthetic process 6/1115 62/18722 0.162671452471605 0.406222116345135 SLC11A2/IREB2/NFE2L1/OPN3/APPL1/RAPGEF2 6 GO:0051047 positive regulation of secretion 23/1115 310/18722 0.163480016798952 0.407616543570543 EGFR/LRP1/WLS/SLC6A4/SCIN/DYNLL1/PPIA/GJA1/EXPH5/P2RX4/SYT7/KCNN4/ATP6AP1/TCF7L2/KIF5B/FRMD4A/MYH10/RAB3GAP1/C1QTNF1/ACSL3/EDNRB/ISL1/PLA2R1 23 GO:0016311 dephosphorylation 30/1115 417/18722 0.16383936072694 0.407616543570543 PTPRF/HSP90B1/SLC39A10/PLPP3/BOD1L1/PPIA/CALM1/HSP90AB1/SGPP1/YWHAE/DLG1/PTPN14/PTPRA/ROCK1/SMPD1/NCEH1/PDP2/PPP6R2/PTP4A1/PPP1R12A/ATP1A1/PTPRM/PPP6R3/PPP4R1/DNAJC6/PTPRK/PPP1R15B/G6PC3/PPP3CA/CDKN3 30 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 4/1115 36/18722 0.164375054936763 0.407616543570543 LGMN/CD74/CTSD/CTSF 4 GO:0003230 cardiac atrium development 4/1115 36/18722 0.164375054936763 0.407616543570543 MDM4/GJA5/BMPR2/ISL1 4 GO:0009225 nucleotide-sugar metabolic process 4/1115 36/18722 0.164375054936763 0.407616543570543 EXTL2/GNE/UXS1/MGAT1 4 GO:0010762 regulation of fibroblast migration 4/1115 36/18722 0.164375054936763 0.407616543570543 ITGB1/GNA12/CLN3/APPL1 4 GO:0036314 response to sterol 4/1115 36/18722 0.164375054936763 0.407616543570543 DAG1/ABCA1/TGFBR1/SMAD2 4 GO:0038179 neurotrophin signaling pathway 4/1115 36/18722 0.164375054936763 0.407616543570543 KIDINS220/ZDHHC17/CYFIP2/RAPGEF2 4 GO:0045738 negative regulation of DNA repair 4/1115 36/18722 0.164375054936763 0.407616543570543 RPS3/UBR5/RIF1/TRIP12 4 GO:0051385 response to mineralocorticoid 4/1115 36/18722 0.164375054936763 0.407616543570543 ATP2B1/CALM1/CCND1/RPL27 4 GO:0051955 regulation of amino acid transport 4/1115 36/18722 0.164375054936763 0.407616543570543 ITGB1/SLC43A2/ARL6IP5/RAB3GAP1 4 GO:0070873 regulation of glycogen metabolic process 4/1115 36/18722 0.164375054936763 0.407616543570543 EPM2AIP1/SORBS1/HMGB1/INSR 4 GO:0090322 regulation of superoxide metabolic process 4/1115 36/18722 0.164375054936763 0.407616543570543 EGFR/BMP7/GSTP1/SOD1 4 GO:1903539 protein localization to postsynaptic membrane 4/1115 36/18722 0.164375054936763 0.407616543570543 DAG1/ADAM10/DLG1/CLSTN1 4 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/1115 36/18722 0.164375054936763 0.407616543570543 FZD5/UBE2L3/NPEPPS/SREBF2 4 GO:0006874 cellular calcium ion homeostasis 32/1115 448/18722 0.164462964972676 0.40764520426607 TPT1/LRP1/ATP2B1/ITGAV/HSP90B1/APP/ATP2B4/ATP13A3/GJA1/CALM1/HEXB/P2RX4/ITPR2/MCOLN3/YWHAE/ATP2A2/GRINA/GTF2I/DMD/TMEM64/TRPV4/CCDC47/C1QTNF1/CLN3/HMGB1/CAV1/S1PR3/EDNRB/PKD2/IBTK/ATP7B/WFS1 32 GO:0007622 rhythmic behavior 5/1115 49/18722 0.165389565841273 0.408425019438741 ADRB1/ZFHX3/NCOR1/NAGLU/NCOA2 5 GO:0008038 neuron recognition 5/1115 49/18722 0.165389565841273 0.408425019438741 NRP1/APP/RTN4/NRCAM/PALLD 5 GO:0030857 negative regulation of epithelial cell differentiation 5/1115 49/18722 0.165389565841273 0.408425019438741 JAG1/CAV1/CCND1/S1PR3/CTNNB1 5 GO:0042461 photoreceptor cell development 5/1115 49/18722 0.165389565841273 0.408425019438741 TUG1/PRKCI/MYO7A/NAGLU/AHI1 5 GO:0043330 response to exogenous dsRNA 5/1115 49/18722 0.165389565841273 0.408425019438741 COLEC12/DHX36/CAV1/TLR3/MAVS 5 GO:0046580 negative regulation of Ras protein signal transduction 5/1115 49/18722 0.165389565841273 0.408425019438741 MET/ITGB1/KANK1/RASA1/CCDC125 5 GO:0086009 membrane repolarization 5/1115 49/18722 0.165389565841273 0.408425019438741 AKAP9/YWHAE/GJA5/ATP1A1/CAV1 5 GO:1904752 regulation of vascular associated smooth muscle cell migration 5/1115 49/18722 0.165389565841273 0.408425019438741 LRP1/IQGAP1/GNA12/ADAMTS1/RHOA 5 GO:0001937 negative regulation of endothelial cell proliferation 7/1115 76/18722 0.165961582537774 0.409458821242688 FLT1/NF1/GJA1/TGFBR1/NR2F2/PTPRM/CAV1 7 GO:0021536 diencephalon development 7/1115 76/18722 0.165961582537774 0.409458821242688 CDH1/NRP2/NRP1/RBPJ/RAB3GAP1/BMPR1A/ISL1 7 GO:0014896 muscle hypertrophy 9/1115 104/18722 0.166650243444499 0.410588670858412 IL6ST/ATP2B4/P2RX4/SLC9A1/ATP2A2/AKAP13/ROCK1/JARID2/PPP3CA 9 GO:0048661 positive regulation of smooth muscle cell proliferation 9/1115 104/18722 0.166650243444499 0.410588670858412 EGFR/GJA1/ADAMTS1/SKP2/FOXP1/PDGFD/BMPR1A/FGFR2/HPGD 9 GO:0060419 heart growth 9/1115 104/18722 0.166650243444499 0.410588670858412 GJA1/TGFBR3/AKAP13/TGFBR1/JARID2/RBPJ/MAPK14/BMPR1A/FGFR2 9 GO:0032392 DNA geometric change 8/1115 90/18722 0.167010544866272 0.411096956680972 ANXA1/ATRX/HMGB3/DHX36/CHD6/HNRNPA2B1/HMGB1/NAV2 8 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 8/1115 90/18722 0.167010544866272 0.411096956680972 GJA1/GNA12/GSTP1/ADAMTS1/S1PR2/BMPR1A/RHOA/HPGD 8 GO:0021953 central nervous system neuron differentiation 13/1115 162/18722 0.168971134152338 0.412956968075528 NRP2/NRP1/MYCBP2/HSP90AB1/B4GALT5/SCYL2/NFIB/GLI3/TSKU/FGFR2/ISL1/C21orf91/RAPGEF2 13 GO:0001702 gastrulation with mouth forming second 3/1115 24/18722 0.169081088633284 0.412956968075528 LRP5/AMOT/CTNNB1 3 GO:0001783 B cell apoptotic process 3/1115 24/18722 0.169081088633284 0.412956968075528 SLC39A10/CD74/FOXP1 3 GO:0003181 atrioventricular valve morphogenesis 3/1115 24/18722 0.169081088633284 0.412956968075528 MDM4/BMPR2/BMPR1A 3 GO:0006582 melanin metabolic process 3/1115 24/18722 0.169081088633284 0.412956968075528 OPN3/APPL1/RAPGEF2 3 GO:0010288 response to lead ion 3/1115 24/18722 0.169081088633284 0.412956968075528 APP/DNMT3A/CAT 3 GO:0018230 peptidyl-L-cysteine S-palmitoylation 3/1115 24/18722 0.169081088633284 0.412956968075528 ZDHHC20/ZDHHC17/ZDHHC21 3 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 3/1115 24/18722 0.169081088633284 0.412956968075528 ZDHHC20/ZDHHC17/ZDHHC21 3 GO:0032928 regulation of superoxide anion generation 3/1115 24/18722 0.169081088633284 0.412956968075528 EGFR/GSTP1/SOD1 3 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 3/1115 24/18722 0.169081088633284 0.412956968075528 PUM2/PUM1/ANKRD17 3 GO:0051570 regulation of histone H3-K9 methylation 3/1115 24/18722 0.169081088633284 0.412956968075528 ATRX/RIF1/JARID2 3 GO:0051647 nucleus localization 3/1115 24/18722 0.169081088633284 0.412956968075528 SYNE2/PCM1/DYNC1H1 3 GO:0060479 lung cell differentiation 3/1115 24/18722 0.169081088633284 0.412956968075528 RBPJ/NFIB/CTNNB1 3 GO:0060561 apoptotic process involved in morphogenesis 3/1115 24/18722 0.169081088633284 0.412956968075528 LRP5/BMP7/FZD5 3 GO:0060571 morphogenesis of an epithelial fold 3/1115 24/18722 0.169081088633284 0.412956968075528 BMP7/FGFR2/CTNNB1 3 GO:0070935 3'-UTR-mediated mRNA stabilization 3/1115 24/18722 0.169081088633284 0.412956968075528 MAPK14/HNRNPC/YBX3 3 GO:0072530 purine-containing compound transmembrane transport 3/1115 24/18722 0.169081088633284 0.412956968075528 SLC19A1/SLC28A2/SLC29A1 3 GO:0070588 calcium ion transmembrane transport 23/1115 312/18722 0.170977438199917 0.417397596044517 AHNAK/ATP2B1/ITGAV/ATP2B4/CALM1/ANO6/P2RX4/ITPR2/MCOLN3/YWHAE/SLC9A1/ATP2A2/C4orf3/SEC61A1/TMEM37/TRPM7/VDAC1/DMD/TRPV4/PKD2/IBTK/ANXA2/VMP1 23 GO:1902373 negative regulation of mRNA catabolic process 6/1115 63/18722 0.171392894476871 0.418220595800737 YBX1/MAPK14/HNRNPC/HNRNPD/FUS/YBX3 6 GO:0010906 regulation of glucose metabolic process 10/1115 119/18722 0.17159344787592 0.4185186926494 RANBP2/DDB1/SLC35B4/EPM2AIP1/SORBS1/C1QTNF1/HMGB1/SOGA1/NCOA2/INSR 10 GO:0044839 cell cycle G2/M phase transition 12/1115 148/18722 0.172195771942617 0.41941296824892 PBX1/NPM1/APP/CALM1/BRD4/USP47/TAOK1/SKP2/TAOK3/CCND1/FOXO4/ATM 12 GO:1903900 regulation of viral life cycle 12/1115 148/18722 0.172195771942617 0.41941296824892 HACD3/CD74/PPIA/PKN2/DDB1/P4HB/MPHOSPH8/TOP2B/LY6E/TRIM38/MAVS/TRIM13 12 GO:2001056 positive regulation of cysteine-type endopeptidase activity 12/1115 148/18722 0.172195771942617 0.41941296824892 LGMN/ASPH/CTSD/RPS3/ARL6IP5/HMGB1/CFLAR/REST/CYFIP2/CYCS/HSPE1/RHOA 12 GO:0000302 response to reactive oxygen species 17/1115 222/18722 0.173017278527879 0.421221728253692 EGFR/MET/ANXA1/LDHA/PRDX1/RPS3/BMP7/NET1/GSTP1/PTPRK/PDGFD/PPP1R15B/PKD2/TRA2B/CAT/PRDX3/SOD1 17 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 9/1115 105/18722 0.17333893718483 0.421620312359821 PFN1/NRP1/TGFBR1/NCKAP1/WASL/COBL/ABI2/OCLN/WASF2 9 GO:2001022 positive regulation of response to DNA damage stimulus 9/1115 105/18722 0.17333893718483 0.421620312359821 EGFR/PRKDC/RPS3/RPL26/RIF1/HMGB1/ATM/PLA2R1/FUS 9 GO:0006354 DNA-templated transcription, elongation 8/1115 91/18722 0.174247828282118 0.421657188146359 BRD4/TCERG1/ARID1A/SERTAD2/SETD2/CDK12/CDK13/CTNNB1 8 GO:0042147 retrograde transport, endosome to Golgi 8/1115 91/18722 0.174247828282118 0.421657188146359 CLTC/GCC2/TMEM87A/RAB6A/CLN5/EVI5/HEATR5A/RHOBTB3 8 GO:1990874 vascular associated smooth muscle cell proliferation 8/1115 91/18722 0.174247828282118 0.421657188146359 GJA1/GNA12/GSTP1/ADAMTS1/S1PR2/BMPR1A/RHOA/HPGD 8 GO:0006633 fatty acid biosynthetic process 13/1115 163/18722 0.174301635413945 0.421657188146359 ANXA1/HACD3/MIF/CD74/ACSS1/PTGES3/GSTP1/DEGS1/TECR/ABCD3/ACSL3/ELOVL1/FASN 13 GO:0071322 cellular response to carbohydrate stimulus 13/1115 163/18722 0.174301635413945 0.421657188146359 LRP1/COLEC12/LRP5/IGF1R/ZFP36L1/DYNLL1/SERPINF1/CCDC186/KIF5B/SLC29A1/EFNA5/PPP3CA/TRA2B 13 GO:0007632 visual behavior 5/1115 50/18722 0.175407695459365 0.421657188146359 ITGB1/APP/NF1/MEIS2/PIAS1 5 GO:0018023 peptidyl-lysine trimethylation 5/1115 50/18722 0.175407695459365 0.421657188146359 ATRX/BRD4/TET2/SETD2/KMT2A 5 GO:0060425 lung morphogenesis 5/1115 50/18722 0.175407695459365 0.421657188146359 DAG1/DLG5/NFIB/FGFR2/CTNNB1 5 GO:0071709 membrane assembly 5/1115 50/18722 0.175407695459365 0.421657188146359 ANK3/SPTBN1/S100A10/CAV1/ANXA2 5 GO:1904738 vascular associated smooth muscle cell migration 5/1115 50/18722 0.175407695459365 0.421657188146359 LRP1/IQGAP1/GNA12/ADAMTS1/RHOA 5 GO:0001819 positive regulation of cytokine production 33/1115 467/18722 0.175453136497119 0.421657188146359 GAPDH/LRP1/CD46/IL6ST/ANXA1/APP/MIF/CD74/RPS3/SPTBN1/FURIN/TRIM56/FZD5/FERMT1/ADAM17/TRPV4/HSPB1/FOXP1/DHX36/SETD2/HMGB1/SEMA7A/MAPK14/APPL1/BMPR1A/TLR3/AGPAT1/ISL1/MAVS/HSPA1A/PLA2R1/CADM1/SOD1 33 GO:0019439 aromatic compound catabolic process 33/1115 467/18722 0.175453136497119 0.421657188146359 NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/TET2/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/PDE10A/PDE7A/TDG/RC3H1/ATM/MGAT1/HSPA1A/HNRNPD/SND1/FUS/YBX3 33 GO:0006109 regulation of carbohydrate metabolic process 14/1115 178/18722 0.175783287438719 0.421657188146359 APP/CLTC/RANBP2/NCOR1/SCARB2/DDB1/SLC35B4/EPM2AIP1/SORBS1/C1QTNF1/HMGB1/SOGA1/NCOA2/INSR 14 GO:0003176 aortic valve development 4/1115 37/18722 0.17621827810194 0.421657188146359 JAG1/ROCK1/RBPJ/BMPR2 4 GO:0030513 positive regulation of BMP signaling pathway 4/1115 37/18722 0.17621827810194 0.421657188146359 RBPJ/BMPR2/SMAD2/GPC3 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/1115 37/18722 0.17621827810194 0.421657188146359 CLTC/EPM2AIP1/SORBS1/INSR 4 GO:0033120 positive regulation of RNA splicing 4/1115 37/18722 0.17621827810194 0.421657188146359 SLC38A2/TRA2B/NCL/HSPA1A 4 GO:0034260 negative regulation of GTPase activity 4/1115 37/18722 0.17621827810194 0.421657188146359 ARFGEF1/AMOT/WNK1/F11R 4 GO:0043403 skeletal muscle tissue regeneration 4/1115 37/18722 0.17621827810194 0.421657188146359 DAG1/ANXA1/CFLAR/PPP3CA 4 GO:0043687 post-translational protein modification 4/1115 37/18722 0.17621827810194 0.421657188146359 STT3B/P3H1/STT3A/CRTAP 4 GO:0045616 regulation of keratinocyte differentiation 4/1115 37/18722 0.17621827810194 0.421657188146359 ZFP36L1/NCOA3/SGPP1/ROCK1 4 GO:0050775 positive regulation of dendrite morphogenesis 4/1115 37/18722 0.17621827810194 0.421657188146359 CUX1/CDKL5/DHX36/OBSL1 4 GO:0051567 histone H3-K9 methylation 4/1115 37/18722 0.17621827810194 0.421657188146359 ASH1L/ATRX/RIF1/JARID2 4 GO:0060306 regulation of membrane repolarization 4/1115 37/18722 0.17621827810194 0.421657188146359 AKAP9/YWHAE/GJA5/CAV1 4 GO:0062237 protein localization to postsynapse 4/1115 37/18722 0.17621827810194 0.421657188146359 DAG1/ADAM10/DLG1/CLSTN1 4 GO:1902745 positive regulation of lamellipodium organization 4/1115 37/18722 0.17621827810194 0.421657188146359 NCKAP1/ABI2/OCLN/WASF2 4 GO:1905332 positive regulation of morphogenesis of an epithelium 4/1115 37/18722 0.17621827810194 0.421657188146359 LGR4/GJA1/MAGED1/CTNNB1 4 GO:0006631 fatty acid metabolic process 28/1115 390/18722 0.176337168543922 0.421657188146359 ANXA1/HACD3/SLC27A2/ASAH1/MIF/CD74/ACSS1/PTGES3/ATP6V1B1/NCOR1/GSTP1/AASDH/CROT/DEGS1/LYPLA1/ECHDC2/TECR/SLC27A6/CPT2/MAPK14/ABCD3/CAV1/ACSL3/ACOX1/ELOVL1/FASN/GPAT4/HPGD 28 GO:0032368 regulation of lipid transport 12/1115 149/18722 0.177849697146899 0.421657188146359 LRP1/ITGAV/ABCA1/TMEM30A/FURIN/P2RX4/C1QTNF1/CAV1/SREBF2/LPCAT3/ANXA2/PLA2R1 12 GO:0002761 regulation of myeloid leukocyte differentiation 10/1115 120/18722 0.177926661377208 0.421657188146359 FBN1/CDK6/ZFP36L1/CD74/ATP6AP1/KLF10/TMEM64/FOXP1/TLR3/CTNNB1 10 GO:0007052 mitotic spindle organization 10/1115 120/18722 0.177926661377208 0.421657188146359 TACC2/TPR/CLTC/DYNC1H1/KPNB1/RAN/ZNF207/CDC20/HSPA1A/RHOA 10 GO:0007494 midgut development 2/1115 13/18722 0.179277358511376 0.421657188146359 EGFR/EDNRB 2 GO:0008298 intracellular mRNA localization 2/1115 13/18722 0.179277358511376 0.421657188146359 ZFP36L1/DHX36 2 GO:0009437 carnitine metabolic process 2/1115 13/18722 0.179277358511376 0.421657188146359 CROT/CPT2 2 GO:0009650 UV protection 2/1115 13/18722 0.179277358511376 0.421657188146359 SCARA3/CAT 2 GO:0010745 negative regulation of macrophage derived foam cell differentiation 2/1115 13/18722 0.179277358511376 0.421657188146359 ITGAV/ABCA1 2 GO:0021859 pyramidal neuron differentiation 2/1115 13/18722 0.179277358511376 0.421657188146359 SCYL2/FGFR2 2 GO:0031053 primary miRNA processing 2/1115 13/18722 0.179277358511376 0.421657188146359 SMAD2/HNRNPA2B1 2 GO:0031392 regulation of prostaglandin biosynthetic process 2/1115 13/18722 0.179277358511376 0.421657188146359 ANXA1/CD74 2 GO:0032252 secretory granule localization 2/1115 13/18722 0.179277358511376 0.421657188146359 USO1/KIF5B 2 GO:0032905 transforming growth factor beta1 production 2/1115 13/18722 0.179277358511376 0.421657188146359 FURIN/TSKU 2 GO:0033689 negative regulation of osteoblast proliferation 2/1115 13/18722 0.179277358511376 0.421657188146359 PLXNB1/ATRAID 2 GO:0042659 regulation of cell fate specification 2/1115 13/18722 0.179277358511376 0.421657188146359 ESRP1/BMPR1A 2 GO:0042769 DNA damage response, detection of DNA damage 2/1115 13/18722 0.179277358511376 0.421657188146359 RPS3/DNAJA1 2 GO:0043970 histone H3-K9 acetylation 2/1115 13/18722 0.179277358511376 0.421657188146359 ZNF451/KMT2A 2 GO:0044794 positive regulation by host of viral process 2/1115 13/18722 0.179277358511376 0.421657188146359 CFL1/STOM 2 GO:0046512 sphingosine biosynthetic process 2/1115 13/18722 0.179277358511376 0.421657188146359 ASAH1/SPTLC3 2 GO:0046520 sphingoid biosynthetic process 2/1115 13/18722 0.179277358511376 0.421657188146359 ASAH1/SPTLC3 2 GO:0048012 hepatocyte growth factor receptor signaling pathway 2/1115 13/18722 0.179277358511376 0.421657188146359 MET/NRP1 2 GO:0048266 behavioral response to pain 2/1115 13/18722 0.179277358511376 0.421657188146359 P2RX4/VWA1 2 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/1115 13/18722 0.179277358511376 0.421657188146359 CALM1/PKD2 2 GO:0051956 negative regulation of amino acid transport 2/1115 13/18722 0.179277358511376 0.421657188146359 SLC43A2/ARL6IP5 2 GO:0060100 positive regulation of phagocytosis, engulfment 2/1115 13/18722 0.179277358511376 0.421657188146359 ANO6/RAB31 2 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1115 13/18722 0.179277358511376 0.421657188146359 TNRC6B/AGO2 2 GO:0060347 heart trabecula formation 2/1115 13/18722 0.179277358511376 0.421657188146359 TGFBR3/ADAMTS1 2 GO:0060707 trophoblast giant cell differentiation 2/1115 13/18722 0.179277358511376 0.421657188146359 HECTD1/NR2F2 2 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 2/1115 13/18722 0.179277358511376 0.421657188146359 XIAP/HSPA1A 2 GO:0071696 ectodermal placode development 2/1115 13/18722 0.179277358511376 0.421657188146359 NRP1/CTNNB1 2 GO:0071801 regulation of podosome assembly 2/1115 13/18722 0.179277358511376 0.421657188146359 ASAP1/RHOA 2 GO:0072310 glomerular epithelial cell development 2/1115 13/18722 0.179277358511376 0.421657188146359 IQGAP1/JAG1 2 GO:0072710 response to hydroxyurea 2/1115 13/18722 0.179277358511376 0.421657188146359 ATRX/DDI2 2 GO:0090158 endoplasmic reticulum membrane organization 2/1115 13/18722 0.179277358511376 0.421657188146359 RTN4/LPCAT3 2 GO:0090161 Golgi ribbon formation 2/1115 13/18722 0.179277358511376 0.421657188146359 TRIP11/GCC2 2 GO:0098840 protein transport along microtubule 2/1115 13/18722 0.179277358511376 0.421657188146359 KIF5B/HSPB1 2 GO:0099118 microtubule-based protein transport 2/1115 13/18722 0.179277358511376 0.421657188146359 KIF5B/HSPB1 2 GO:1900044 regulation of protein K63-linked ubiquitination 2/1115 13/18722 0.179277358511376 0.421657188146359 UBR5/TRIP12 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/1115 13/18722 0.179277358511376 0.421657188146359 ATF6/TMEM33 2 GO:1900121 negative regulation of receptor binding 2/1115 13/18722 0.179277358511376 0.421657188146359 PTPRF/ATP2A2 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/1115 13/18722 0.179277358511376 0.421657188146359 APP/PPP1R9A 2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 2/1115 13/18722 0.179277358511376 0.421657188146359 NSD1/TMSB4X 2 GO:1903977 positive regulation of glial cell migration 2/1115 13/18722 0.179277358511376 0.421657188146359 LRP1/P2RX4 2 GO:1905155 positive regulation of membrane invagination 2/1115 13/18722 0.179277358511376 0.421657188146359 ANO6/RAB31 2 GO:1905203 regulation of connective tissue replacement 2/1115 13/18722 0.179277358511376 0.421657188146359 ROCK1/PPP3CA 2 GO:1905244 regulation of modification of synaptic structure 2/1115 13/18722 0.179277358511376 0.421657188146359 CLN3/RHOA 2 GO:1990403 embryonic brain development 2/1115 13/18722 0.179277358511376 0.421657188146359 TRA2B/CTNNB1 2 GO:0006090 pyruvate metabolic process 9/1115 106/18722 0.18014914124349 0.422580534532366 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/VDAC1/INSR 9 GO:0019882 antigen processing and presentation 9/1115 106/18722 0.18014914124349 0.422580534532366 LGMN/CD74/CTSD/LNPEP/CTSF/RAB6A/ERAP1/TAPBP/MR1 9 GO:0071887 leukocyte apoptotic process 9/1115 106/18722 0.18014914124349 0.422580534532366 ANXA1/RPS6/SLC39A10/CD74/DOCK8/ADAM17/GLI3/FOXP1/RAPGEF2 9 GO:0045670 regulation of osteoclast differentiation 6/1115 64/18722 0.180303138727239 0.422580534532366 FBN1/ATP6AP1/KLF10/TMEM64/TLR3/CTNNB1 6 GO:0098930 axonal transport 6/1115 64/18722 0.180303138727239 0.422580534532366 DST/DYNC1H1/KIF5B/HSPB1/TRAK2/SOD1 6 GO:1900076 regulation of cellular response to insulin stimulus 6/1115 64/18722 0.180303138727239 0.422580534532366 ATP2B1/KANK1/MYO1C/USO1/SORBS1/OSBPL8 6 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 6/1115 64/18722 0.180303138727239 0.422580534532366 RPL23/RPL5/HSP90AB1/USP25/SMARCC1/EIF3H 6 GO:1903409 reactive oxygen species biosynthetic process 6/1115 64/18722 0.180303138727239 0.422580534532366 SLC5A3/CLCN3/CFLAR/ACOX1/RHOA/SOD1 6 GO:1901991 negative regulation of mitotic cell cycle phase transition 14/1115 179/18722 0.180977299173379 0.423974462609334 ZFP36L1/PRKDC/TPR/USP47/RPL26/TAOK1/DLG1/TAOK3/JADE1/CCND1/ZNF207/PKD2/FOXO4/ATM 14 GO:0006497 protein lipidation 8/1115 92/18722 0.181622365386633 0.425112586058411 ABCA1/PGAP1/GPAA1/ZDHHC20/RAB3GAP1/RAB3GAP2/ZDHHC17/ZDHHC21 8 GO:0031058 positive regulation of histone modification 8/1115 92/18722 0.181622365386633 0.425112586058411 NIPBL/BRD4/RPS6KA5/RIF1/JARID2/KMT2A/ISL1/CTNNB1 8 GO:1901654 response to ketone 15/1115 194/18722 0.181762147565175 0.425246829617904 EGFR/ATP2B1/CALM1/TGFBR3/GLB1/SERPINF1/NR3C1/XRN1/CLDN4/NCOA2/CFLAR/CAV1/CCND1/RPL27/HNRNPD 15 GO:0032371 regulation of sterol transport 7/1115 78/18722 0.181918666201029 0.425246829617904 LRP1/ABCA1/FURIN/CAV1/SREBF2/LPCAT3/ANXA2 7 GO:0032374 regulation of cholesterol transport 7/1115 78/18722 0.181918666201029 0.425246829617904 LRP1/ABCA1/FURIN/CAV1/SREBF2/LPCAT3/ANXA2 7 GO:0001959 regulation of cytokine-mediated signaling pathway 12/1115 150/18722 0.183591761919318 0.425515082729283 SPPL2A/CD74/HSP90AB1/GSTP1/TRIM44/PARP14/ADAM17/SPPL2B/CAV1/AGPAT1/MAVS/HSPA1A 12 GO:0016050 vesicle organization 22/1115 300/18722 0.183611327243847 0.425515082729283 ANXA1/ABCA1/EEA1/USO1/SCARB2/SYT7/KIF5B/SEC31A/PRKCI/CLCN3/HOOK2/S100A10/MIA3/WASL/MYO7A/YIPF4/VAV3/CLN3/CAV1/TMEM127/RAB13/ANXA2 22 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 3/1115 25/18722 0.184185307396024 0.425515082729283 GJA1/GJA5/RHOA 3 GO:0010447 response to acidic pH 3/1115 25/18722 0.184185307396024 0.425515082729283 LGMN/SERPINF1/SLC9A1 3 GO:0010842 retina layer formation 3/1115 25/18722 0.184185307396024 0.425515082729283 PTPRM/AHI1/OBSL1 3 GO:0021846 cell proliferation in forebrain 3/1115 25/18722 0.184185307396024 0.425515082729283 PCM1/GLI3/FGFR2 3 GO:0034389 lipid droplet organization 3/1115 25/18722 0.184185307396024 0.425515082729283 PPIA/CDS1/RAB3GAP1 3 GO:0035336 long-chain fatty-acyl-CoA metabolic process 3/1115 25/18722 0.184185307396024 0.425515082729283 TECR/ACSL3/ELOVL1 3 GO:0044550 secondary metabolite biosynthetic process 3/1115 25/18722 0.184185307396024 0.425515082729283 OPN3/APPL1/RAPGEF2 3 GO:0045109 intermediate filament organization 3/1115 25/18722 0.184185307396024 0.425515082729283 PLEC/DSP/PKP2 3 GO:0046039 GTP metabolic process 3/1115 25/18722 0.184185307396024 0.425515082729283 AK3/RAN/RHOA 3 GO:0046949 fatty-acyl-CoA biosynthetic process 3/1115 25/18722 0.184185307396024 0.425515082729283 TECR/ACSL3/ELOVL1 3 GO:0048596 embryonic camera-type eye morphogenesis 3/1115 25/18722 0.184185307396024 0.425515082729283 BMP7/FZD5/PHACTR4 3 GO:0051450 myoblast proliferation 3/1115 25/18722 0.184185307396024 0.425515082729283 MALAT1/MEIS2/ZNF609 3 GO:0060074 synapse maturation 3/1115 25/18722 0.184185307396024 0.425515082729283 PFN1/CLSTN1/CDC20 3 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 3/1115 25/18722 0.184185307396024 0.425515082729283 MED13/DHX36/SUB1 3 GO:0060740 prostate gland epithelium morphogenesis 3/1115 25/18722 0.184185307396024 0.425515082729283 BMP7/FEM1B/FGFR2 3 GO:0071450 cellular response to oxygen radical 3/1115 25/18722 0.184185307396024 0.425515082729283 PRDX1/BMP7/SOD1 3 GO:0071451 cellular response to superoxide 3/1115 25/18722 0.184185307396024 0.425515082729283 PRDX1/BMP7/SOD1 3 GO:0072012 glomerulus vasculature development 3/1115 25/18722 0.184185307396024 0.425515082729283 BMP7/PDGFD/CFLAR 3 GO:0090330 regulation of platelet aggregation 3/1115 25/18722 0.184185307396024 0.425515082729283 IL6ST/F11R/C1QTNF1 3 GO:1900078 positive regulation of cellular response to insulin stimulus 3/1115 25/18722 0.184185307396024 0.425515082729283 MYO1C/SORBS1/OSBPL8 3 GO:1901623 regulation of lymphocyte chemotaxis 3/1115 25/18722 0.184185307396024 0.425515082729283 ADAM10/ADAM17/WNK1 3 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 3/1115 25/18722 0.184185307396024 0.425515082729283 EGFR/NCOR1/PPP3CA 3 GO:1904385 cellular response to angiotensin 3/1115 25/18722 0.184185307396024 0.425515082729283 ROCK1/AHCYL1/CAV1 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/1115 25/18722 0.184185307396024 0.425515082729283 LRP1/IQGAP1/ADAMTS1 3 GO:1905564 positive regulation of vascular endothelial cell proliferation 3/1115 25/18722 0.184185307396024 0.425515082729283 ADAM17/AKT3/HMGB1 3 GO:0043500 muscle adaptation 10/1115 121/18722 0.184366668504138 0.425749845650343 DAG1/IL6ST/ATP2B4/P2RX4/SLC9A1/ATP2A2/ROCK1/JARID2/CFLAR/PPP3CA 10 GO:0050796 regulation of insulin secretion 13/1115 165/18722 0.185207057894443 0.427505612666853 LRP1/LRP5/DPP4/DYNLL1/GJA1/SYT7/SLC16A1/TCF7L2/KIF5B/EFNA5/PPP3CA/REST/ISL1 13 GO:0009948 anterior/posterior axis specification 5/1115 51/18722 0.1856496289958 0.428156962941069 WLS/PGAP1/FZD5/GPC3/CTNNB1 5 GO:0014009 glial cell proliferation 5/1115 51/18722 0.1856496289958 0.428156962941069 EGFR/DICER1/UFL1/PRKCI/PLAG1 5 GO:0015698 inorganic anion transport 14/1115 180/18722 0.186245522212436 0.429345787172796 SLC26A2/SLC13A4/PCYOX1/GABRE/SLC22A11/ANO6/SLC5A6/ANKH/SLC4A2/VDAC1/SLC1A3/CLCN3/CLDN4/CLIC3 14 GO:0043414 macromolecule methylation 23/1115 316/18722 0.186514145690152 0.429779466482401 ASH1L/ATRX/BRD4/KMT2C/DNMT3A/TET2/RIF1/ZC3H13/NSD1/RAB6A/MPHOSPH8/PRMT9/JARID2/RNMT/SETD2/KMT2A/PCMTD1/SUZ12/ATF7IP/TARBP1/CREBBP/CTNNB1/SNRPB 23 GO:0043624 cellular protein complex disassembly 11/1115 136/18722 0.187354581772351 0.431529815393693 CFL1/SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/TRPV4/DNAJC6/CAMSAP2/EIF5A/DSTN 11 GO:0000578 embryonic axis specification 4/1115 38/18722 0.188340165341592 0.432122106901056 FZD5/SMAD2/COBL/CTNNB1 4 GO:0010613 positive regulation of cardiac muscle hypertrophy 4/1115 38/18722 0.188340165341592 0.432122106901056 IL6ST/SLC9A1/ROCK1/PPP3CA 4 GO:0032941 secretion by tissue 4/1115 38/18722 0.188340165341592 0.432122106901056 EGFR/COPA/KCNN4/WNK1 4 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 4/1115 38/18722 0.188340165341592 0.432122106901056 NCOR1/FOXP1/ISL1/RHOA 4 GO:0042596 fear response 4/1115 38/18722 0.188340165341592 0.432122106901056 ADRB1/DPP4/GJA1/VDAC1 4 GO:0046329 negative regulation of JNK cascade 4/1115 38/18722 0.188340165341592 0.432122106901056 NCOR1/GSTP1/TAOK3/DNAJA1 4 GO:0071392 cellular response to estradiol stimulus 4/1115 38/18722 0.188340165341592 0.432122106901056 EGFR/NCOA3/CFLAR/HNRNPD 4 GO:0099622 cardiac muscle cell membrane repolarization 4/1115 38/18722 0.188340165341592 0.432122106901056 AKAP9/YWHAE/GJA5/ATP1A1 4 GO:1903580 positive regulation of ATP metabolic process 4/1115 38/18722 0.188340165341592 0.432122106901056 APP/ENO1/TMSB4X/INSR 4 GO:0033273 response to vitamin 8/1115 93/18722 0.189129933356564 0.432925758420486 EGFR/ATP2B1/BMP7/DNMT3A/FOLR1/GSTP1/CCND1/CAT 8 GO:0051591 response to cAMP 8/1115 93/18722 0.189129933356564 0.432925758420486 AKAP9/LDHA/APP/ZFP36L1/ITPR2/HSPA5/PKD2/RAPGEF2 8 GO:0090398 cellular senescence 8/1115 93/18722 0.189129933356564 0.432925758420486 CDK6/PRKDC/YBX1/AKT3/MAPK14/BMPR1A/ATM/PLA2R1 8 GO:1901019 regulation of calcium ion transmembrane transporter activity 8/1115 93/18722 0.189129933356564 0.432925758420486 AHNAK/CALM1/YWHAE/SLC9A1/C4orf3/DMD/PKD2/VMP1 8 GO:0035418 protein localization to synapse 6/1115 65/18722 0.189393996364879 0.432925758420486 DAG1/ADAM10/DLG1/CLSTN1/KIF5B/HSPB1 6 GO:0060389 pathway-restricted SMAD protein phosphorylation 6/1115 65/18722 0.189393996364879 0.432925758420486 LRP1/TGFBR3/BMP7/TGFBR1/BMPR2/BMPR1A 6 GO:0070613 regulation of protein processing 6/1115 65/18722 0.189393996364879 0.432925758420486 GLG1/ENO1/CLN3/CAST/XIAP/LPCAT3 6 GO:0090307 mitotic spindle assembly 6/1115 65/18722 0.189393996364879 0.432925758420486 TPR/KPNB1/ZNF207/CDC20/HSPA1A/RHOA 6 GO:0030902 hindbrain development 12/1115 151/18722 0.189420223201022 0.432925758420486 ITGB1/WLS/SLC6A4/BMP7/HSPA5/NCSTN/NFIB/NAGLU/AHI1/RERE/CTNNB1/HNRNPD 12 GO:1901184 regulation of ERBB signaling pathway 7/1115 79/18722 0.190129141675145 0.434360071631836 EGFR/LGMN/RTN4/IFI6/RBPJ/ADAM17/RHBDF1 7 GO:0002688 regulation of leukocyte chemotaxis 10/1115 122/18722 0.190910862618043 0.435773020742937 LGMN/MIF/DPP4/CD74/ANO6/ADAM10/ADAM17/WNK1/TRPV4/HMGB1 10 GO:0031109 microtubule polymerization or depolymerization 10/1115 122/18722 0.190910862618043 0.435773020742937 AKAP9/MET/CLIP1/RPS3/TAOK1/TRPV4/CAMSAP2/ZNF207/OCLN/HSPA1A 10 GO:0045766 positive regulation of angiogenesis 14/1115 181/18722 0.191586674890691 0.436569038515321 ITGB1/GRN/FLT1/NRP1/ITGB8/GAB1/HSPB1/EMC10/AGO2/AKT3/HMGB1/TLR3/ERAP1/ISL1 14 GO:0099504 synaptic vesicle cycle 14/1115 181/18722 0.191586674890691 0.436569038515321 CANX/ACTG1/CALM1/KIAA1109/STON1/ATP2A2/SYT7/ROCK1/CLCN3/RAB3GAP1/DNAJC6/ITSN2/ACTB/CTNNB1 14 GO:1904018 positive regulation of vasculature development 14/1115 181/18722 0.191586674890691 0.436569038515321 ITGB1/GRN/FLT1/NRP1/ITGB8/GAB1/HSPB1/EMC10/AGO2/AKT3/HMGB1/TLR3/ERAP1/ISL1 14 GO:1905952 regulation of lipid localization 14/1115 181/18722 0.191586674890691 0.436569038515321 LRP1/ITGAV/PLIN2/ABCA1/TMEM30A/FURIN/P2RX4/C1QTNF1/OSBPL8/CAV1/SREBF2/LPCAT3/ANXA2/PLA2R1 14 GO:0000086 G2/M transition of mitotic cell cycle 11/1115 137/18722 0.193563455248229 0.440885361591423 PBX1/APP/CALM1/BRD4/USP47/TAOK1/SKP2/TAOK3/CCND1/FOXO4/ATM 11 GO:0030217 T cell differentiation 19/1115 257/18722 0.19505687828211 0.443487827819812 CD46/ANXA1/RPS6/ZFP36L1/CD74/PRKDC/FZD5/ADAM17/GLI3/FOXP1/HMGB1/PTPRK/CLPTM1/RC3H1/ERBB2/MR1/CTNNB1/RHOA/SOD1 19 GO:0098754 detoxification 12/1115 152/18722 0.19533326189114 0.443487827819812 PRDX1/BMP7/PRDX4/GPX3/GSTP1/SLC22A5/SLC22A18/GPX8/CAT/ATP7B/PRDX3/SOD1 12 GO:0030514 negative regulation of BMP signaling pathway 5/1115 52/18722 0.196102508289208 0.443487827819812 FBN1/LRP2/CRIM1/TRIM33/SMURF2 5 GO:0043277 apoptotic cell clearance 5/1115 52/18722 0.196102508289208 0.443487827819812 LRP1/ANXA1/ITGAV/HMGB1/RHOBTB1 5 GO:0048260 positive regulation of receptor-mediated endocytosis 5/1115 52/18722 0.196102508289208 0.443487827819812 SCYL2/WASL/AHI1/INSR/ANXA2 5 GO:0051496 positive regulation of stress fiber assembly 5/1115 52/18722 0.196102508289208 0.443487827819812 NRP1/CD47/TGFBR1/S100A10/RHOA 5 GO:0002690 positive regulation of leukocyte chemotaxis 8/1115 94/18722 0.196766144062757 0.443487827819812 LGMN/CD74/ANO6/ADAM10/ADAM17/WNK1/TRPV4/HMGB1 8 GO:0009749 response to glucose 16/1115 212/18722 0.196983512079713 0.443487827819812 LRP1/LRP5/IGF1R/LDHA/DYNLL1/GJA1/SERPINF1/CCDC186/TCF7L2/KIF5B/SLC29A1/SMAD2/EFNA5/PPP3CA/TRA2B/RHOA 16 GO:0060401 cytosolic calcium ion transport 14/1115 182/18722 0.196999420450173 0.443487827819812 ATP2B1/ATP2B4/CALM1/P2RX4/ITPR2/MCOLN3/YWHAE/ATP2A2/VDAC1/DMD/TRPV4/CAV1/PKD2/IBTK 14 GO:0071482 cellular response to light stimulus 10/1115 123/18722 0.197556529415443 0.443487827819812 MME/NPM1/USP47/RPL26/DDB1/SMPD1/DHX36/PTPRK/OPN3/CREBBP 10 GO:0031667 response to nutrient levels 33/1115 474/18722 0.198187544467207 0.443487827819812 EGFR/ATP2B1/CSH1/HNRNPA1/SLC2A1/AGL/LDHA/ABCA1/SLC6A4/ADRB1/SLC38A2/PLEC/BMP7/KRT18/DNMT3A/FOLR1/GSTP1/SLC16A1/LAMP2/HSPA5/AOC1/KLF10/TTPA/CPEB4/TRPV4/BMPR2/CCND1/ACSL3/SREBF2/CAT/FOXO4/ITFG2/SOD1 33 GO:0071300 cellular response to retinoic acid 6/1115 66/18722 0.198657020108108 0.443487827819812 ABCA1/SLC6A4/SERPINF1/FGFR2/PTK7/ATM 6 GO:1902476 chloride transmembrane transport 6/1115 66/18722 0.198657020108108 0.443487827819812 SLC26A2/PCYOX1/GABRE/ANO6/SLC1A3/CLCN3 6 GO:0002092 positive regulation of receptor internalization 3/1115 26/18722 0.199626501574048 0.443487827819812 SCYL2/AHI1/INSR 3 GO:0006760 folic acid-containing compound metabolic process 3/1115 26/18722 0.199626501574048 0.443487827819812 SLC19A1/FOLR1/GGH 3 GO:0010875 positive regulation of cholesterol efflux 3/1115 26/18722 0.199626501574048 0.443487827819812 LRP1/ABCA1/CAV1 3 GO:0018027 peptidyl-lysine dimethylation 3/1115 26/18722 0.199626501574048 0.443487827819812 ASH1L/SETD2/KMT2A 3 GO:0019883 antigen processing and presentation of endogenous antigen 3/1115 26/18722 0.199626501574048 0.443487827819812 CD74/ERAP1/TAPBP 3 GO:0021680 cerebellar Purkinje cell layer development 3/1115 26/18722 0.199626501574048 0.443487827819812 HSPA5/NAGLU/RERE 3 GO:0021952 central nervous system projection neuron axonogenesis 3/1115 26/18722 0.199626501574048 0.443487827819812 MYCBP2/NFIB/TSKU 3 GO:0034114 regulation of heterotypic cell-cell adhesion 3/1115 26/18722 0.199626501574048 0.443487827819812 GCNT2/BMP7/WNK1 3 GO:0042634 regulation of hair cycle 3/1115 26/18722 0.199626501574048 0.443487827819812 NIPBL/FERMT1/TSKU 3 GO:0043501 skeletal muscle adaptation 3/1115 26/18722 0.199626501574048 0.443487827819812 ATP2A2/CFLAR/PPP3CA 3 GO:0045672 positive regulation of osteoclast differentiation 3/1115 26/18722 0.199626501574048 0.443487827819812 ATP6AP1/KLF10/TMEM64 3 GO:0046697 decidualization 3/1115 26/18722 0.199626501574048 0.443487827819812 ASH1L/GJA1/CTSB 3 GO:0048668 collateral sprouting 3/1115 26/18722 0.199626501574048 0.443487827819812 LRP1/APP/COBL 3 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 3/1115 26/18722 0.199626501574048 0.443487827819812 CALM1/DMD/PKD2 3 GO:0060352 cell adhesion molecule production 3/1115 26/18722 0.199626501574048 0.443487827819812 COLEC12/PPIA/CAV1 3 GO:0060544 regulation of necroptotic process 3/1115 26/18722 0.199626501574048 0.443487827819812 CFLAR/CAV1/YBX3 3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 3/1115 26/18722 0.199626501574048 0.443487827819812 EGFR/NCOR1/PPP3CA 3 GO:0072273 metanephric nephron morphogenesis 3/1115 26/18722 0.199626501574048 0.443487827819812 LGR4/PKD2/CTNNB1 3 GO:0097186 amelogenesis 3/1115 26/18722 0.199626501574048 0.443487827819812 CSF3R/SLC4A2/ITGB6 3 GO:2000050 regulation of non-canonical Wnt signaling pathway 3/1115 26/18722 0.199626501574048 0.443487827819812 ZNRF3/RNF213/GPC3 3 GO:0007618 mating 4/1115 39/18722 0.200718489239153 0.443487827819812 SLC6A4/APP/HEXB/EDNRB 4 GO:0014742 positive regulation of muscle hypertrophy 4/1115 39/18722 0.200718489239153 0.443487827819812 IL6ST/SLC9A1/ROCK1/PPP3CA 4 GO:0017158 regulation of calcium ion-dependent exocytosis 4/1115 39/18722 0.200718489239153 0.443487827819812 ATP2A2/SYT7/RAB3GAP1/REST 4 GO:0031507 heterochromatin assembly 4/1115 39/18722 0.200718489239153 0.443487827819812 TPR/DNMT3A/MPHOSPH8/ATF7IP 4 GO:0032728 positive regulation of interferon-beta production 4/1115 39/18722 0.200718489239153 0.443487827819812 TRIM56/HMGB1/TLR3/MAVS 4 GO:0046621 negative regulation of organ growth 4/1115 39/18722 0.200718489239153 0.443487827819812 SLC6A4/GJA1/JARID2/WWC2 4 GO:0071548 response to dexamethasone 4/1115 39/18722 0.200718489239153 0.443487827819812 EGFR/SERPINF1/NR3C1/CFLAR 4 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 4/1115 39/18722 0.200718489239153 0.443487827819812 CALM1/SLC9A1/PKD2/VMP1 4 GO:0034766 negative regulation of ion transmembrane transport 9/1115 109/18722 0.201276076382687 0.443487827819812 SLC43A2/CALM1/ANK3/ARL6IP5/YWHAE/C4orf3/VDAC1/CAV1/PKD2 9 GO:0000054 ribosomal subunit export from nucleus 2/1115 14/18722 0.201351282006972 0.443487827819812 NPM1/RAN 2 GO:0001771 immunological synapse formation 2/1115 14/18722 0.201351282006972 0.443487827819812 DOCK8/DLG1 2 GO:0002467 germinal center formation 2/1115 14/18722 0.201351282006972 0.443487827819812 ADAM17/RC3H1 2 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2/1115 14/18722 0.201351282006972 0.443487827819812 S1PR2/S1PR3 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/1115 14/18722 0.201351282006972 0.443487827819812 TRIP11/TSKU 2 GO:0006047 UDP-N-acetylglucosamine metabolic process 2/1115 14/18722 0.201351282006972 0.443487827819812 GNE/MGAT1 2 GO:0006521 regulation of cellular amino acid metabolic process 2/1115 14/18722 0.201351282006972 0.443487827819812 ATP2B4/CLN3 2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 2/1115 14/18722 0.201351282006972 0.443487827819812 PRLR/EFNA5 2 GO:0009214 cyclic nucleotide catabolic process 2/1115 14/18722 0.201351282006972 0.443487827819812 PDE10A/PDE7A 2 GO:0010839 negative regulation of keratinocyte proliferation 2/1115 14/18722 0.201351282006972 0.443487827819812 PTPRK/FGFR2 2 GO:0022038 corpus callosum development 2/1115 14/18722 0.201351282006972 0.443487827819812 RYK/TSKU 2 GO:0031054 pre-miRNA processing 2/1115 14/18722 0.201351282006972 0.443487827819812 DICER1/AGO2 2 GO:0033750 ribosome localization 2/1115 14/18722 0.201351282006972 0.443487827819812 NPM1/RAN 2 GO:0034616 response to laminar fluid shear stress 2/1115 14/18722 0.201351282006972 0.443487827819812 ABCA1/SREBF2 2 GO:0035672 oligopeptide transmembrane transport 2/1115 14/18722 0.201351282006972 0.443487827819812 GJA1/SLC13A3 2 GO:0036295 cellular response to increased oxygen levels 2/1115 14/18722 0.201351282006972 0.443487827819812 ATP6AP1/CAV1 2 GO:0045989 positive regulation of striated muscle contraction 2/1115 14/18722 0.201351282006972 0.443487827819812 ATP1A1/TRPV4 2 GO:0046655 folic acid metabolic process 2/1115 14/18722 0.201351282006972 0.443487827819812 SLC19A1/FOLR1 2 GO:0048172 regulation of short-term neuronal synaptic plasticity 2/1115 14/18722 0.201351282006972 0.443487827819812 RAB3GAP1/CLN3 2 GO:0048368 lateral mesoderm development 2/1115 14/18722 0.201351282006972 0.443487827819812 SMAD2/BMPR1A 2 GO:0060088 auditory receptor cell stereocilium organization 2/1115 14/18722 0.201351282006972 0.443487827819812 MYO7A/SOD1 2 GO:0060841 venous blood vessel development 2/1115 14/18722 0.201351282006972 0.443487827819812 BMPR2/ACVR2B 2 GO:0060911 cardiac cell fate commitment 2/1115 14/18722 0.201351282006972 0.443487827819812 RBPJ/ISL1 2 GO:0061709 reticulophagy 2/1115 14/18722 0.201351282006972 0.443487827819812 RB1CC1/UFL1 2 GO:0071285 cellular response to lithium ion 2/1115 14/18722 0.201351282006972 0.443487827819812 CDH1/ADCY7 2 GO:0071481 cellular response to X-ray 2/1115 14/18722 0.201351282006972 0.443487827819812 NIPBL/ATM 2 GO:0072160 nephron tubule epithelial cell differentiation 2/1115 14/18722 0.201351282006972 0.443487827819812 MTSS1/CTNNB1 2 GO:0072350 tricarboxylic acid metabolic process 2/1115 14/18722 0.201351282006972 0.443487827819812 IREB2/IDH1 2 GO:0072498 embryonic skeletal joint development 2/1115 14/18722 0.201351282006972 0.443487827819812 BMP7/CTNNB1 2 GO:0090128 regulation of synapse maturation 2/1115 14/18722 0.201351282006972 0.443487827819812 CLSTN1/CDC20 2 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 2/1115 14/18722 0.201351282006972 0.443487827819812 MPHOSPH8/ATF7IP 2 GO:1900037 regulation of cellular response to hypoxia 2/1115 14/18722 0.201351282006972 0.443487827819812 ENO1/CHCHD2 2 GO:1901857 positive regulation of cellular respiration 2/1115 14/18722 0.201351282006972 0.443487827819812 IL10RB/OPN3 2 GO:1902036 regulation of hematopoietic stem cell differentiation 2/1115 14/18722 0.201351282006972 0.443487827819812 N4BP2L2/PRKDC 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/1115 14/18722 0.201351282006972 0.443487827819812 MIF/CD74 2 GO:1902916 positive regulation of protein polyubiquitination 2/1115 14/18722 0.201351282006972 0.443487827819812 SKP2/XIAP 2 GO:1904294 positive regulation of ERAD pathway 2/1115 14/18722 0.201351282006972 0.443487827819812 TMEM259/CAV1 2 GO:2001171 positive regulation of ATP biosynthetic process 2/1115 14/18722 0.201351282006972 0.443487827819812 ENO1/TMSB4X 2 GO:0009132 nucleoside diphosphate metabolic process 10/1115 124/18722 0.204300852247036 0.449369031789889 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/DLG1/TPI1/AK3/INSR 10 GO:0010508 positive regulation of autophagy 10/1115 124/18722 0.204300852247036 0.449369031789889 ATF6/ROCK1/UFL1/VDAC1/C9orf72/RAB3GAP1/HMGB1/RAB3GAP2/TRIM38/TRIM13 10 GO:0097237 cellular response to toxic substance 10/1115 124/18722 0.204300852247036 0.449369031789889 PRDX1/BMP7/PRDX4/GPX3/GSTP1/PPP1R9A/GPX8/CAT/PRDX3/SOD1 10 GO:0032479 regulation of type I interferon production 8/1115 95/18722 0.204526455750034 0.449369031789889 GAPDH/TRIM56/DHX36/SETD2/HMGB1/REL/TLR3/MAVS 8 GO:0032606 type I interferon production 8/1115 95/18722 0.204526455750034 0.449369031789889 GAPDH/TRIM56/DHX36/SETD2/HMGB1/REL/TLR3/MAVS 8 GO:0048709 oligodendrocyte differentiation 8/1115 95/18722 0.204526455750034 0.449369031789889 DAG1/NF1/B4GALT5/GSTP1/NCSTN/GLI3/ERBB2/CTNNB1 8 GO:0051783 regulation of nuclear division 11/1115 139/18722 0.20625193651183 0.452719704194108 LRP5/BMP7/TPR/PHIP/ZNF207/OBSL1/INSR/CDK13/ATM/NUSAP1/CDC20 11 GO:0045444 fat cell differentiation 17/1115 229/18722 0.206365345826828 0.452719704194108 LRP5/ADRB1/NIPBL/ZFP36L1/BMP7/ADIRF/CDS1/JAG1/TCF7L2/TMEM64/TRPV4/PIAS1/MAPK14/OSBPL8/CCND1/ARID5B/ERAP1 17 GO:0016925 protein sumoylation 5/1115 53/18722 0.206753210329466 0.452719704194108 RANBP2/ZNF451/SENP6/PIAS1/CTNNB1 5 GO:0031279 regulation of cyclase activity 5/1115 53/18722 0.206753210329466 0.452719704194108 AKAP9/NF1/CALM1/MAPK14/EDNRB 5 GO:0032784 regulation of DNA-templated transcription, elongation 5/1115 53/18722 0.206753210329466 0.452719704194108 BRD4/TCERG1/CDK12/CDK13/CTNNB1 5 GO:0043620 regulation of DNA-templated transcription in response to stress 5/1115 53/18722 0.206753210329466 0.452719704194108 ATF6/HSPA5/RBPJ/CHD6/HSPA1A 5 GO:2000772 regulation of cellular senescence 5/1115 53/18722 0.206753210329466 0.452719704194108 CDK6/PRKDC/YBX1/AKT3/BMPR1A 5 GO:0044773 mitotic DNA damage checkpoint signaling 7/1115 81/18722 0.206984228870166 0.452719704194108 PRKDC/RPL26/TAOK1/TAOK3/CCND1/FOXO4/ATM 7 GO:0048708 astrocyte differentiation 7/1115 81/18722 0.206984228870166 0.452719704194108 EGFR/LRP1/IL6ST/GRN/CDK6/APP/NF1 7 GO:0051817 modulation of process of other organism involved in symbiotic interaction 7/1115 81/18722 0.206984228870166 0.452719704194108 DAG1/CFL1/ANO6/STOM/INSR/REST/SERPINB9 7 GO:2000106 regulation of leukocyte apoptotic process 7/1115 81/18722 0.206984228870166 0.452719704194108 ANXA1/SLC39A10/CD74/DOCK8/ADAM17/FOXP1/RAPGEF2 7 GO:0032890 regulation of organic acid transport 6/1115 67/18722 0.208083536363661 0.454379550366294 ITGB1/SLC43A2/ARL6IP5/P2RX4/RAB3GAP1/PLA2R1 6 GO:0048814 regulation of dendrite morphogenesis 6/1115 67/18722 0.208083536363661 0.454379550366294 CUX1/CDKL5/DHX36/OBSL1/PPP3CA/RAPGEF2 6 GO:1902117 positive regulation of organelle assembly 6/1115 67/18722 0.208083536363661 0.454379550366294 DYNC1H1/CNOT6L/RAB3GAP1/RAB3GAP2/ASAP1/RHOA 6 GO:1903317 regulation of protein maturation 6/1115 67/18722 0.208083536363661 0.454379550366294 GLG1/ENO1/CLN3/CAST/XIAP/LPCAT3 6 GO:0006939 smooth muscle contraction 9/1115 110/18722 0.208538935805482 0.454630207540004 ATP2B1/ATP2B4/DLG1/ROCK1/CAV1/ZDHHC21/EDNRB/RHOA/SOD1 9 GO:0032611 interleukin-1 beta production 9/1115 110/18722 0.208538935805482 0.454630207540004 APP/GSTP1/FZD5/HSPB1/FOXP1/HMGB1/S1PR3/ISL1/SERPINB1 9 GO:0032651 regulation of interleukin-1 beta production 9/1115 110/18722 0.208538935805482 0.454630207540004 APP/GSTP1/FZD5/HSPB1/FOXP1/HMGB1/S1PR3/ISL1/SERPINB1 9 GO:0048259 regulation of receptor-mediated endocytosis 9/1115 110/18722 0.208538935805482 0.454630207540004 ITGAV/AAK1/SCYL2/WASL/DNAJC6/AHI1/INSR/MKLN1/ANXA2 9 GO:0030595 leukocyte chemotaxis 17/1115 230/18722 0.211359946135359 0.460592143843543 CSF3R/ANXA1/FLT1/LGMN/MIF/DPP4/CD74/PPIA/ANO6/PLEC/ADAM10/ADAM17/WNK1/TRPV4/VAV3/HMGB1/EDNRB 17 GO:0042158 lipoprotein biosynthetic process 8/1115 96/18722 0.212406184816531 0.462306001115148 ABCA1/PGAP1/GPAA1/ZDHHC20/RAB3GAP1/RAB3GAP2/ZDHHC17/ZDHHC21 8 GO:0042472 inner ear morphogenesis 8/1115 96/18722 0.212406184816531 0.462306001115148 ATP6V1B1/MYO7A/FZD6/MYO6/FGFR2/FZD3/PTK7/SOD1 8 GO:1904035 regulation of epithelial cell apoptotic process 8/1115 96/18722 0.212406184816531 0.462306001115148 ZFP36L1/ANO6/TCF7L2/PRKCI/CFLAR/CAST/WFS1/PLA2R1 8 GO:0007292 female gamete generation 11/1115 140/18722 0.212726799115925 0.462815150969813 LGR5/RPS6/DIAPH2/HEXB/USP9X/ADAMTS1/ZFX/PAQR7/CTNNB1/MLH3/HPGD 11 GO:0002791 regulation of peptide secretion 15/1115 200/18722 0.213139326203503 0.462997455571432 EGFR/LRP1/LRP5/DPP4/CD74/DYNLL1/GJA1/SYT7/SLC16A1/TCF7L2/KIF5B/EFNA5/PPP3CA/REST/ISL1 15 GO:0099003 vesicle-mediated transport in synapse 15/1115 200/18722 0.213139326203503 0.462997455571432 CANX/ACTG1/CALM1/KIAA1109/STON1/ATP2A2/SYT7/ROCK1/CLSTN1/CLCN3/RAB3GAP1/DNAJC6/ITSN2/ACTB/CTNNB1 15 GO:0032892 positive regulation of organic acid transport 4/1115 40/18722 0.213330912288017 0.462997455571432 ITGB1/P2RX4/RAB3GAP1/PLA2R1 4 GO:0045429 positive regulation of nitric oxide biosynthetic process 4/1115 40/18722 0.213330912288017 0.462997455571432 P2RX4/HSP90AB1/INSR/PKD2 4 GO:0072210 metanephric nephron development 4/1115 40/18722 0.213330912288017 0.462997455571432 LGR4/PKD2/CTNNB1/IRX2 4 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 4/1115 40/18722 0.213330912288017 0.462997455571432 CALM1/YWHAE/C4orf3/PKD2 4 GO:0010970 transport along microtubule 12/1115 155/18722 0.213560569408767 0.463119366398622 APP/DST/ARHGAP21/PCM1/RAB6A/DYNC1H1/KIF5B/LRPPRC/HSPB1/CLN3/TRAK2/SOD1 12 GO:0034614 cellular response to reactive oxygen species 12/1115 155/18722 0.213560569408767 0.463119366398622 EGFR/MET/ANXA1/PRDX1/RPS3/BMP7/NET1/PTPRK/PDGFD/PKD2/PRDX3/SOD1 12 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 3/1115 27/18722 0.215359516922887 0.464567458929816 CD47/VAV3/APPL1 3 GO:0006783 heme biosynthetic process 3/1115 27/18722 0.215359516922887 0.464567458929816 SLC11A2/IREB2/NFE2L1 3 GO:0009651 response to salt stress 3/1115 27/18722 0.215359516922887 0.464567458929816 ZFP36L1/HSP90AB1/TRPV4 3 GO:0010894 negative regulation of steroid biosynthetic process 3/1115 27/18722 0.215359516922887 0.464567458929816 ATP1A1/REST/SOD1 3 GO:0015813 L-glutamate transmembrane transport 3/1115 27/18722 0.215359516922887 0.464567458929816 ITGB1/ARL6IP5/SLC1A3 3 GO:0031954 positive regulation of protein autophosphorylation 3/1115 27/18722 0.215359516922887 0.464567458929816 IQGAP1/CALM1/PDGFD 3 GO:0034377 plasma lipoprotein particle assembly 3/1115 27/18722 0.215359516922887 0.464567458929816 ABCA1/ACSL3/LPCAT3 3 GO:0035235 ionotropic glutamate receptor signaling pathway 3/1115 27/18722 0.215359516922887 0.464567458929816 APP/CPEB4/CLN3 3 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 3/1115 27/18722 0.215359516922887 0.464567458929816 CD47/VAV3/APPL1 3 GO:0039529 RIG-I signaling pathway 3/1115 27/18722 0.215359516922887 0.464567458929816 PUM2/PUM1/ANKRD17 3 GO:0042403 thyroid hormone metabolic process 3/1115 27/18722 0.215359516922887 0.464567458929816 CTSB/GCNT4/SLC16A2 3 GO:0060512 prostate gland morphogenesis 3/1115 27/18722 0.215359516922887 0.464567458929816 BMP7/FEM1B/FGFR2 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/1115 27/18722 0.215359516922887 0.464567458929816 OXR1/REST/CTNNB1 3 GO:0001938 positive regulation of endothelial cell proliferation 9/1115 111/18722 0.215905992835998 0.46518244380605 NRP2/NRP1/TGFBR1/RICTOR/ADAM17/BMPR2/EMC10/AKT3/HMGB1 9 GO:0015718 monocarboxylic acid transport 9/1115 111/18722 0.215905992835998 0.46518244380605 ANXA1/SLC16A12/P2RX4/SLC5A6/SLC16A4/SLC16A1/ABCD3/SLC16A2/PLA2R1 9 GO:0090288 negative regulation of cellular response to growth factor stimulus 9/1115 111/18722 0.215905992835998 0.46518244380605 FBN1/LRP2/CRIM1/SEMA6A/ATP2B4/GPC1/TRIM33/CFLAR/SMURF2 9 GO:1901361 organic cyclic compound catabolic process 34/1115 495/18722 0.216289110202059 0.465819910999917 STS/NPM1/DICER1/ZFP36L1/KCNQ1OT1/YBX1/TNRC6B/SMG1/TET2/ROCK1/TTC37/LRPPRC/CNOT6L/PUM2/XRN1/CELF1/DHX36/DCP2/PUM1/AGO2/MAPK14/HNRNPC/MOV10/PDE10A/PDE7A/TDG/RC3H1/ATM/MGAT1/HSPA1A/HNRNPD/SND1/FUS/YBX3 34 GO:0007215 glutamate receptor signaling pathway 5/1115 54/18722 0.217588405734289 0.467462473612764 APP/GNAQ/NCSTN/CPEB4/CLN3 5 GO:0030520 intracellular estrogen receptor signaling pathway 5/1115 54/18722 0.217588405734289 0.467462473612764 DDX17/UFL1/ARID1A/SKP2/ISL1 5 GO:0030834 regulation of actin filament depolymerization 5/1115 54/18722 0.217588405734289 0.467462473612764 SCIN/SPTBN1/ADD3/SPTAN1/DSTN 5 GO:1902743 regulation of lamellipodium organization 5/1115 54/18722 0.217588405734289 0.467462473612764 KANK1/NCKAP1/ABI2/OCLN/WASF2 5 GO:2000179 positive regulation of neural precursor cell proliferation 5/1115 54/18722 0.217588405734289 0.467462473612764 LRP2/ADGRG1/GLI3/FZD3/CTNNB1 5 GO:0009988 cell-cell recognition 6/1115 68/18722 0.217664676793656 0.467462473612764 ALDOA/DOCK8/B4GALT1/DLG1/FOLR1/CCT3 6 GO:0051148 negative regulation of muscle cell differentiation 6/1115 68/18722 0.217664676793656 0.467462473612764 YBX1/BMPR2/NFATC3/BMPR1A/ANKRD17/FOXO4 6 GO:0031929 TOR signaling 10/1115 126/18722 0.2180737203907 0.46796446670657 RPS6/GNA12/SMG1/SLC38A9/RICTOR/C9orf72/AKT3/TMEM127/ITFG2/ATM 10 GO:0032874 positive regulation of stress-activated MAPK cascade 10/1115 126/18722 0.2180737203907 0.46796446670657 APP/ARL6IP5/RB1CC1/TAOK1/TRPV4/TAOK3/EMC10/HMGB1/TLR3/LTBR 10 GO:0050727 regulation of inflammatory response 27/1115 386/18722 0.218800298404455 0.469334991233984 EGFR/NEAT1/IL6ST/GRN/ANXA1/APP/ASH1L/CTSC/BRD4/SERPINF1/FURIN/GSTP1/UFL1/CD47/RICTOR/TRPV4/TMSB4X/CELF1/FOXP1/SEMA7A/MAPK14/EDNRB/XIAP/LPCAT3/TLR3/ISL1/SOD1 27 GO:0034341 response to interferon-gamma 11/1115 141/18722 0.219285450086349 0.469921469863132 GAPDH/RPL13A/ACTG1/CD74/HSP90AB1/MYO1C/SEC61A1/CD47/KIF5B/PARP14/TLR3 11 GO:0048284 organelle fusion 11/1115 141/18722 0.219285450086349 0.469921469863132 ANXA1/EEA1/USO1/SYT7/TFRC/KIF5B/YIPF4/VAV3/CLN3/RAB13/ANXA2 11 GO:0120032 regulation of plasma membrane bounded cell projection assembly 14/1115 186/18722 0.219337760423099 0.469921469863132 KANK1/PFN1/NRP1/CDKL5/TGFBR1/NCKAP1/PPP1R9A/WASL/CLN3/COBL/CAV1/ABI2/OCLN/WASF2 14 GO:0035335 peptidyl-tyrosine dephosphorylation 8/1115 97/18722 0.220400517649294 0.471156599846405 PTPRF/PTPN14/PTPRA/PTP4A1/PTPRM/DNAJC6/PTPRK/CDKN3 8 GO:0043255 regulation of carbohydrate biosynthetic process 8/1115 97/18722 0.220400517649294 0.471156599846405 CLTC/RANBP2/DDB1/SLC35B4/EPM2AIP1/SORBS1/SOGA1/INSR 8 GO:0120162 positive regulation of cold-induced thermogenesis 8/1115 97/18722 0.220400517649294 0.471156599846405 IGF1R/PRLR/ADRB1/GJA1/ESRRG/DYNC1H1/CPT2/CAV1 8 GO:0007159 leukocyte cell-cell adhesion 26/1115 371/18722 0.221170390820407 0.471156599846405 CD46/IL6ST/ITGB1/ANXA1/DPP4/OLR1/CD74/NFAT5/RPS3/DOCK8/BMP7/DLG5/DLG1/ROCK1/CD47/TFRC/WNK1/GLI3/F11R/MIA3/HMGB1/CAV1/ZDHHC21/RC3H1/ERBB2/RHOA 26 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/1115 15/18722 0.223708930625704 0.471156599846405 RPL7/RPL35 2 GO:0006704 glucocorticoid biosynthetic process 2/1115 15/18722 0.223708930625704 0.471156599846405 ATP1A1/REST 2 GO:0006825 copper ion transport 2/1115 15/18722 0.223708930625704 0.471156599846405 SLC11A2/ATP7B 2 GO:0006878 cellular copper ion homeostasis 2/1115 15/18722 0.223708930625704 0.471156599846405 APP/ATP7B 2 GO:0010889 regulation of sequestering of triglyceride 2/1115 15/18722 0.223708930625704 0.471156599846405 PLIN2/OSBPL8 2 GO:0014733 regulation of skeletal muscle adaptation 2/1115 15/18722 0.223708930625704 0.471156599846405 ATP2A2/PPP3CA 2 GO:0015697 quaternary ammonium group transport 2/1115 15/18722 0.223708930625704 0.471156599846405 SLC38A2/SLC22A5 2 GO:0018146 keratan sulfate biosynthetic process 2/1115 15/18722 0.223708930625704 0.471156599846405 B3GNT2/B3GNT3 2 GO:0032239 regulation of nucleobase-containing compound transport 2/1115 15/18722 0.223708930625704 0.471156599846405 TPR/SETD2 2 GO:0033599 regulation of mammary gland epithelial cell proliferation 2/1115 15/18722 0.223708930625704 0.471156599846405 RTN4/CCND1 2 GO:0036376 sodium ion export across plasma membrane 2/1115 15/18722 0.223708930625704 0.471156599846405 SLC9A1/ATP1A1 2 GO:0042159 lipoprotein catabolic process 2/1115 15/18722 0.223708930625704 0.471156599846405 CTSD/LYPLA1 2 GO:0042249 establishment of planar polarity of embryonic epithelium 2/1115 15/18722 0.223708930625704 0.471156599846405 DVL3/PTK7 2 GO:0042994 cytoplasmic sequestering of transcription factor 2/1115 15/18722 0.223708930625704 0.471156599846405 TMSB4X/PKD2 2 GO:0043508 negative regulation of JUN kinase activity 2/1115 15/18722 0.223708930625704 0.471156599846405 GSTP1/DNAJA1 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/1115 15/18722 0.223708930625704 0.471156599846405 MIF/CD74 2 GO:0048484 enteric nervous system development 2/1115 15/18722 0.223708930625704 0.471156599846405 EDNRB/PHACTR4 2 GO:0051284 positive regulation of sequestering of calcium ion 2/1115 15/18722 0.223708930625704 0.471156599846405 CALM1/PKD2 2 GO:0055091 phospholipid homeostasis 2/1115 15/18722 0.223708930625704 0.471156599846405 ABCA1/ITGB6 2 GO:0060049 regulation of protein glycosylation 2/1115 15/18722 0.223708930625704 0.471156599846405 ARFGEF1/ALG10B 2 GO:0060099 regulation of phagocytosis, engulfment 2/1115 15/18722 0.223708930625704 0.471156599846405 ANO6/RAB31 2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1115 15/18722 0.223708930625704 0.471156599846405 TNRC6B/AGO2 2 GO:0060413 atrial septum morphogenesis 2/1115 15/18722 0.223708930625704 0.471156599846405 BMPR2/ISL1 2 GO:0060456 positive regulation of digestive system process 2/1115 15/18722 0.223708930625704 0.471156599846405 SLC22A5/LPCAT3 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/1115 15/18722 0.223708930625704 0.471156599846405 NCOR1/FOXP1 2 GO:0070207 protein homotrimerization 2/1115 15/18722 0.223708930625704 0.471156599846405 MIF/SLC1A5 2 GO:0070831 basement membrane assembly 2/1115 15/18722 0.223708930625704 0.471156599846405 DAG1/LAMB1 2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 2/1115 15/18722 0.223708930625704 0.471156599846405 TMEM30A/TMEM30B 2 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 2/1115 15/18722 0.223708930625704 0.471156599846405 NPM1/RAN 2 GO:0071474 cellular hyperosmotic response 2/1115 15/18722 0.223708930625704 0.471156599846405 SLC2A1/YBX3 2 GO:0071599 otic vesicle development 2/1115 15/18722 0.223708930625704 0.471156599846405 AHI1/FGFR2 2 GO:0071871 response to epinephrine 2/1115 15/18722 0.223708930625704 0.471156599846405 ATP2B4/SLC9A1 2 GO:0072075 metanephric mesenchyme development 2/1115 15/18722 0.223708930625704 0.471156599846405 BMP7/PKD2 2 GO:0090110 COPII-coated vesicle cargo loading 2/1115 15/18722 0.223708930625704 0.471156599846405 SEC31A/MIA3 2 GO:1900029 positive regulation of ruffle assembly 2/1115 15/18722 0.223708930625704 0.471156599846405 PFN1/COBL 2 GO:1903729 regulation of plasma membrane organization 2/1115 15/18722 0.223708930625704 0.471156599846405 WASL/ASAP1 2 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 2/1115 15/18722 0.223708930625704 0.471156599846405 NCOR1/PPP3CA 2 GO:2000402 negative regulation of lymphocyte migration 2/1115 15/18722 0.223708930625704 0.471156599846405 MIA3/WASL 2 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 2/1115 15/18722 0.223708930625704 0.471156599846405 ANXA1/CD74 2 GO:0090087 regulation of peptide transport 15/1115 202/18722 0.224104208388068 0.471802984457371 EGFR/LRP1/LRP5/DPP4/CD74/DYNLL1/GJA1/SYT7/SLC16A1/TCF7L2/KIF5B/EFNA5/PPP3CA/REST/ISL1 15 GO:1902105 regulation of leukocyte differentiation 20/1115 279/18722 0.225980741973563 0.475370899779628 FBN1/CD46/ANXA1/CDK6/ZFP36L1/CD74/PRKDC/ATP6AP1/KLF10/TMEM64/GLI3/FOXP1/HMGB1/TLR3/CLPTM1/RC3H1/ERBB2/CTNNB1/RHOA/SOD1 20 GO:0032735 positive regulation of interleukin-12 production 4/1115 41/18722 0.226155101224996 0.475370899779628 HMGB1/MAPK14/TLR3/ISL1 4 GO:0051693 actin filament capping 4/1115 41/18722 0.226155101224996 0.475370899779628 SCIN/SPTBN1/ADD3/SPTAN1 4 GO:1904407 positive regulation of nitric oxide metabolic process 4/1115 41/18722 0.226155101224996 0.475370899779628 P2RX4/HSP90AB1/INSR/PKD2 4 GO:0033344 cholesterol efflux 6/1115 69/18722 0.22739140922043 0.477405715229209 LRP1/ABCA1/NPC1/TSKU/CAV1/SREBF2 6 GO:0050810 regulation of steroid biosynthetic process 6/1115 69/18722 0.22739140922043 0.477405715229209 ASAH1/SF1/ATP1A1/LPCAT3/REST/SOD1 6 GO:0060193 positive regulation of lipase activity 6/1115 69/18722 0.22739140922043 0.477405715229209 EGFR/FLT1/GNAQ/FGFR2/ARF4/RHOA 6 GO:0000768 syncytium formation by plasma membrane fusion 5/1115 55/18722 0.228594614743893 0.479178110764683 MAPK14/CFLAR/SH3PXD2A/MYOF/ERVW-1 5 GO:0010676 positive regulation of cellular carbohydrate metabolic process 5/1115 55/18722 0.228594614743893 0.479178110764683 DDB1/EPM2AIP1/SORBS1/HMGB1/INSR 5 GO:0042220 response to cocaine 5/1115 55/18722 0.228594614743893 0.479178110764683 HSP90AB1/DNMT3A/HSPA5/SLC1A3/SMPD1 5 GO:0140253 cell-cell fusion 5/1115 55/18722 0.228594614743893 0.479178110764683 MAPK14/CFLAR/SH3PXD2A/MYOF/ERVW-1 5 GO:0060491 regulation of cell projection assembly 14/1115 188/18722 0.230897964393663 0.48265997569303 KANK1/PFN1/NRP1/CDKL5/TGFBR1/NCKAP1/PPP1R9A/WASL/CLN3/COBL/CAV1/ABI2/OCLN/WASF2 14 GO:0000303 response to superoxide 3/1115 28/18722 0.231340490316251 0.48265997569303 PRDX1/BMP7/SOD1 3 GO:0015740 C4-dicarboxylate transport 3/1115 28/18722 0.231340490316251 0.48265997569303 SLC1A5/SLC1A3/SLC13A3 3 GO:0019098 reproductive behavior 3/1115 28/18722 0.231340490316251 0.48265997569303 APP/HEXB/ZFX 3 GO:0031440 regulation of mRNA 3'-end processing 3/1115 28/18722 0.231340490316251 0.48265997569303 ZFP36L1/AHCYL1/DHX36 3 GO:0038094 Fc-gamma receptor signaling pathway 3/1115 28/18722 0.231340490316251 0.48265997569303 CD47/VAV3/APPL1 3 GO:0042983 amyloid precursor protein biosynthetic process 3/1115 28/18722 0.231340490316251 0.48265997569303 ITM2B/NCSTN/AGO2 3 GO:0042984 regulation of amyloid precursor protein biosynthetic process 3/1115 28/18722 0.231340490316251 0.48265997569303 ITM2B/NCSTN/AGO2 3 GO:0045671 negative regulation of osteoclast differentiation 3/1115 28/18722 0.231340490316251 0.48265997569303 FBN1/TLR3/CTNNB1 3 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 3/1115 28/18722 0.231340490316251 0.48265997569303 PARP14/CAV1/SUZ12 3 GO:0080111 DNA demethylation 3/1115 28/18722 0.231340490316251 0.48265997569303 TET2/USP9X/TDG 3 GO:0086011 membrane repolarization during action potential 3/1115 28/18722 0.231340490316251 0.48265997569303 YWHAE/ATP1A1/CAV1 3 GO:0032612 interleukin-1 production 10/1115 128/18722 0.232205095765751 0.484085515928679 ANXA1/APP/GSTP1/FZD5/HSPB1/FOXP1/HMGB1/S1PR3/ISL1/SERPINB1 10 GO:0032652 regulation of interleukin-1 production 10/1115 128/18722 0.232205095765751 0.484085515928679 ANXA1/APP/GSTP1/FZD5/HSPB1/FOXP1/HMGB1/S1PR3/ISL1/SERPINB1 10 GO:0098586 cellular response to virus 7/1115 84/18722 0.233257751884042 0.485900560791612 IFI6/PUM2/PUM1/MAPK14/TLR3/ANKRD17/EIF5A 7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7/1115 84/18722 0.233257751884042 0.485900560791612 PRKDC/RPL26/DLG1/JADE1/CCND1/PKD2/ATM 7 GO:0030098 lymphocyte differentiation 26/1115 374/18722 0.233429707385091 0.486069113778861 CD46/ITGB1/ANXA1/PBX1/RPS6/ZFP36L1/CD74/PRKDC/HECTD1/FZD5/RBPJ/ADAM17/GLI3/FOXP1/HMGB1/IRF2BP2/PTPRK/CLPTM1/ITFG2/RC3H1/ATM/ERBB2/MR1/CTNNB1/RHOA/SOD1 26 GO:0051656 establishment of organelle localization 27/1115 390/18722 0.234792625053015 0.488716501036276 SYNE2/ITGB1/NPM1/CFL1/GJA1/ARHGAP21/MYO1C/TRIP11/DLG1/ACTN4/EML4/ATP6AP1/PCM1/CCDC186/RAB6A/DYNC1H1/KIF5B/LRPPRC/KPNB1/WASL/MYO7A/CLN3/RAN/TRAK2/MYO6/NUSAP1/CTNNB1 27 GO:0000045 autophagosome assembly 8/1115 99/18722 0.236713161184958 0.492138460890379 RB1CC1/ATP2A2/C9orf72/TMEM41B/RAB3GAP1/RAB3GAP2/ATG9A/VMP1 8 GO:0006165 nucleoside diphosphate phosphorylation 8/1115 99/18722 0.236713161184958 0.492138460890379 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/INSR 8 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 8/1115 99/18722 0.236713161184958 0.492138460890379 TPT1/MIF/CD74/PRKDC/RPS3/USP47/RPL26/ATM 8 GO:0003407 neural retina development 6/1115 70/18722 0.237254567764781 0.493072065899636 ATP2B1/ATP2B4/PTPRM/NAGLU/AHI1/OBSL1 6 GO:0002244 hematopoietic progenitor cell differentiation 9/1115 114/18722 0.238593807521118 0.494044520780927 N4BP2L2/RBM47/FLT1/PRKDC/PRRC2C/UFL1/ZFAT/DHX36/REST 9 GO:0097529 myeloid leukocyte migration 16/1115 220/18722 0.239118767031807 0.494044520780927 CSF3R/ANXA1/FLT1/LGMN/MIF/DPP4/CD74/PPIA/ANO6/P2RX4/CD47/TRPV4/VAV3/HMGB1/PDGFD/EDNRB 16 GO:0007520 myoblast fusion 4/1115 42/18722 0.239168831731551 0.494044520780927 MAPK14/CFLAR/MYOF/ERVW-1 4 GO:0010591 regulation of lamellipodium assembly 4/1115 42/18722 0.239168831731551 0.494044520780927 NCKAP1/ABI2/OCLN/WASF2 4 GO:0010939 regulation of necrotic cell death 4/1115 42/18722 0.239168831731551 0.494044520780927 ASAH1/CFLAR/CAV1/YBX3 4 GO:0030574 collagen catabolic process 4/1115 42/18722 0.239168831731551 0.494044520780927 ITGB1/CTSB/FURIN/MMP15 4 GO:0043507 positive regulation of JUN kinase activity 4/1115 42/18722 0.239168831731551 0.494044520780927 RPS3/FZD5/DVL3/TAOK3 4 GO:0045687 positive regulation of glial cell differentiation 4/1115 42/18722 0.239168831731551 0.494044520780927 SPINT1/DAG1/IL6ST/DICER1 4 GO:0046596 regulation of viral entry into host cell 4/1115 42/18722 0.239168831731551 0.494044520780927 CD74/P4HB/LY6E/TRIM38 4 GO:0046688 response to copper ion 4/1115 42/18722 0.239168831731551 0.494044520780927 APP/AOC1/ATP7B/SOD1 4 GO:0072595 maintenance of protein localization in organelle 4/1115 42/18722 0.239168831731551 0.494044520780927 GJA1/GPAA1/HSPA5/SKP1 4 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/1115 42/18722 0.239168831731551 0.494044520780927 TEAD1/NR3C1/SREBF2/BMPR1A 4 GO:0051051 negative regulation of transport 32/1115 470/18722 0.239757726064235 0.494044520780927 ANXA1/LMAN1/ITGAV/CD74/GABRE/OAZ1/SLC43A2/GJA1/CALM1/ERBB3/ANK3/ARL6IP5/TPR/YWHAE/ERLEC1/C4orf3/CD47/VDAC1/FERMT1/PPP1R9A/FRMD4A/LYPLA1/WNK1/HMGB1/CAV1/SREBF2/APPL1/PKD2/PPP3CA/REST/RHBDF1/PLA2R1 32 GO:0010332 response to gamma radiation 5/1115 56/18722 0.239758260599996 0.494044520780927 PRKDC/RPL26/HSPA5/ATM/TRIM13 5 GO:0010518 positive regulation of phospholipase activity 5/1115 56/18722 0.239758260599996 0.494044520780927 EGFR/FLT1/GNAQ/FGFR2/ARF4 5 GO:0015800 acidic amino acid transport 5/1115 56/18722 0.239758260599996 0.494044520780927 ITGB1/GJA1/ARL6IP5/SLC1A3/RAB3GAP1 5 GO:0032608 interferon-beta production 5/1115 56/18722 0.239758260599996 0.494044520780927 TRIM56/HMGB1/REL/TLR3/MAVS 5 GO:0032648 regulation of interferon-beta production 5/1115 56/18722 0.239758260599996 0.494044520780927 TRIM56/HMGB1/REL/TLR3/MAVS 5 GO:0043470 regulation of carbohydrate catabolic process 5/1115 56/18722 0.239758260599996 0.494044520780927 APP/NCOR1/SCARB2/HMGB1/INSR 5 GO:0051058 negative regulation of small GTPase mediated signal transduction 5/1115 56/18722 0.239758260599996 0.494044520780927 MET/ITGB1/KANK1/RASA1/CCDC125 5 GO:0055078 sodium ion homeostasis 5/1115 56/18722 0.239758260599996 0.494044520780927 ATP6V1B1/SLC9A1/SLC1A3/ATP1A1/EDNRB 5 GO:1904645 response to amyloid-beta 5/1115 56/18722 0.239758260599996 0.494044520780927 LRP1/IGF1R/LGMN/APP/GJA1 5 GO:0044774 mitotic DNA integrity checkpoint signaling 7/1115 85/18722 0.242253651744805 0.498417050738156 PRKDC/RPL26/TAOK1/TAOK3/CCND1/FOXO4/ATM 7 GO:0045069 regulation of viral genome replication 7/1115 85/18722 0.242253651744805 0.498417050738156 HACD3/PPIA/PKN2/DDB1/MPHOSPH8/TOP2B/MAVS 7 GO:0072384 organelle transport along microtubule 7/1115 85/18722 0.242253651744805 0.498417050738156 ARHGAP21/RAB6A/DYNC1H1/KIF5B/LRPPRC/CLN3/TRAK2 7 GO:0097006 regulation of plasma lipoprotein particle levels 7/1115 85/18722 0.242253651744805 0.498417050738156 ABCA1/LIPA/VLDLR/NCEH1/ACSL3/LPCAT3/ANXA2 7 GO:0016072 rRNA metabolic process 17/1115 236/18722 0.242437503111387 0.49860316991976 RPL7/RPS6/RPL5/RPS8/RPS16/RPL7A/RPL14/PRKDC/DDX17/RPS17/RPL26/RPS21/RPS25/RPL10A/XRN1/RPL35/RPL27 17 GO:0046394 carboxylic acid biosynthetic process 22/1115 314/18722 0.244452107466134 0.500206964348393 ANXA1/HACD3/SLC27A2/ATP2B4/MIF/CD74/ACSS1/PTGES3/BCAT1/GSTP1/SERINC3/SLC1A3/DEGS1/MTR/TECR/CLN3/ABCD3/ALDH18A1/ACSL3/BCAT2/ELOVL1/FASN 22 GO:0044728 DNA methylation or demethylation 8/1115 100/18722 0.2450213011014 0.500206964348393 ATRX/DNMT3A/TET2/USP9X/MPHOSPH8/KMT2A/ATF7IP/TDG 8 GO:0043271 negative regulation of ion transport 12/1115 160/18722 0.245441235910489 0.500206964348393 GABRE/SLC43A2/CALM1/ANK3/ARL6IP5/YWHAE/C4orf3/VDAC1/WNK1/CAV1/PKD2/PLA2R1 12 GO:0001977 renal system process involved in regulation of blood volume 2/1115 16/18722 0.246238339200683 0.500206964348393 GJA1/GJA5 2 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/1115 16/18722 0.246238339200683 0.500206964348393 MME/ENPEP 2 GO:0002093 auditory receptor cell morphogenesis 2/1115 16/18722 0.246238339200683 0.500206964348393 MYO7A/SOD1 2 GO:0002693 positive regulation of cellular extravasation 2/1115 16/18722 0.246238339200683 0.500206964348393 CD47/PDGFD 2 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 2/1115 16/18722 0.246238339200683 0.500206964348393 TGFBR1/RBPJ 2 GO:0006555 methionine metabolic process 2/1115 16/18722 0.246238339200683 0.500206964348393 SMS/MTR 2 GO:0006857 oligopeptide transport 2/1115 16/18722 0.246238339200683 0.500206964348393 GJA1/SLC13A3 2 GO:0019081 viral translation 2/1115 16/18722 0.246238339200683 0.500206964348393 PCBP2/EIF3A 2 GO:0021535 cell migration in hindbrain 2/1115 16/18722 0.246238339200683 0.500206964348393 ITGB1/RERE 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/1115 16/18722 0.246238339200683 0.500206964348393 GCNT2/BMP7 2 GO:0036342 post-anal tail morphogenesis 2/1115 16/18722 0.246238339200683 0.500206964348393 CHST11/FZD3 2 GO:0044804 autophagy of nucleus 2/1115 16/18722 0.246238339200683 0.500206964348393 RB1CC1/ATG9A 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/1115 16/18722 0.246238339200683 0.500206964348393 RPS3/KCNN4 2 GO:0050884 neuromuscular process controlling posture 2/1115 16/18722 0.246238339200683 0.500206964348393 GAA/TMEM150C 2 GO:0060330 regulation of response to interferon-gamma 2/1115 16/18722 0.246238339200683 0.500206964348393 HSP90AB1/PARP14 2 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/1115 16/18722 0.246238339200683 0.500206964348393 HSP90AB1/PARP14 2 GO:0070365 hepatocyte differentiation 2/1115 16/18722 0.246238339200683 0.500206964348393 ANXA1/KRT18 2 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 2/1115 16/18722 0.246238339200683 0.500206964348393 TRPV4/HMGB1 2 GO:0090336 positive regulation of brown fat cell differentiation 2/1115 16/18722 0.246238339200683 0.500206964348393 BMP7/MAPK14 2 GO:0090520 sphingolipid mediated signaling pathway 2/1115 16/18722 0.246238339200683 0.500206964348393 S1PR2/S1PR3 2 GO:1902570 protein localization to nucleolus 2/1115 16/18722 0.246238339200683 0.500206964348393 NPM1/RAN 2 GO:1902931 negative regulation of alcohol biosynthetic process 2/1115 16/18722 0.246238339200683 0.500206964348393 REST/SOD1 2 GO:1904948 midbrain dopaminergic neuron differentiation 2/1115 16/18722 0.246238339200683 0.500206964348393 RYK/CTNNB1 2 GO:1905153 regulation of membrane invagination 2/1115 16/18722 0.246238339200683 0.500206964348393 ANO6/RAB31 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/1115 16/18722 0.246238339200683 0.500206964348393 ZNRF3/GPC3 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/1115 16/18722 0.246238339200683 0.500206964348393 PRKDC/RIF1 2 GO:0000077 DNA damage checkpoint signaling 9/1115 115/18722 0.246338664038123 0.500206964348393 PRKDC/RPL26/TAOK1/TAOK3/MAPK14/CCND1/FEM1B/FOXO4/ATM 9 GO:0050818 regulation of coagulation 6/1115 71/18722 0.247244882125004 0.500206964348393 ANXA5/TFPI/ANO6/C1QTNF1/CAV1/ANXA2 6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/1115 29/18722 0.247527027497369 0.500206964348393 TNRC6B/CNOT6L/AGO2 3 GO:0000305 response to oxygen radical 3/1115 29/18722 0.247527027497369 0.500206964348393 PRDX1/BMP7/SOD1 3 GO:0002068 glandular epithelial cell development 3/1115 29/18722 0.247527027497369 0.500206964348393 CDK6/FASN/GPAT4 3 GO:0005979 regulation of glycogen biosynthetic process 3/1115 29/18722 0.247527027497369 0.500206964348393 EPM2AIP1/SORBS1/INSR 3 GO:0009310 amine catabolic process 3/1115 29/18722 0.247527027497369 0.500206964348393 ATP2B4/SLC44A1/SAT1 3 GO:0010955 negative regulation of protein processing 3/1115 29/18722 0.247527027497369 0.500206964348393 GLG1/CAST/XIAP 3 GO:0010962 regulation of glucan biosynthetic process 3/1115 29/18722 0.247527027497369 0.500206964348393 EPM2AIP1/SORBS1/INSR 3 GO:0048265 response to pain 3/1115 29/18722 0.247527027497369 0.500206964348393 P2RX4/VWA1/EDNRB 3 GO:0048665 neuron fate specification 3/1115 29/18722 0.247527027497369 0.500206964348393 GLI3/ESRP1/ISL1 3 GO:0048679 regulation of axon regeneration 3/1115 29/18722 0.247527027497369 0.500206964348393 LRP1/GRN/PTPRF 3 GO:0050686 negative regulation of mRNA processing 3/1115 29/18722 0.247527027497369 0.500206964348393 NPM1/SAP18/SRSF9 3 GO:0070979 protein K11-linked ubiquitination 3/1115 29/18722 0.247527027497369 0.500206964348393 UBE2L3/UBE2H/UBE2C 3 GO:0090025 regulation of monocyte chemotaxis 3/1115 29/18722 0.247527027497369 0.500206964348393 LGMN/ANO6/HMGB1 3 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 3/1115 29/18722 0.247527027497369 0.500206964348393 SEMA6A/ATP2B4/MYO1C 3 GO:1903318 negative regulation of protein maturation 3/1115 29/18722 0.247527027497369 0.500206964348393 GLG1/CAST/XIAP 3 GO:0008654 phospholipid biosynthetic process 18/1115 253/18722 0.250543295779645 0.505919310199518 PGAP1/SERINC1/HEXB/SLC44A2/CDS1/SMG1/GPAA1/SLC44A1/CLN3/ACSL3/PISD/LPCAT3/AGPAT1/ISYNA1/IDH1/ATM/GPAT4/ETNK1 18 GO:0034612 response to tumor necrosis factor 18/1115 253/18722 0.250543295779645 0.505919310199518 KRT8/ASAH1/SPPL2A/ZFP36L1/RPS3/ADAM10/KRT18/ACTN4/GSTP1/SMPD1/ADAM17/TMSB4X/SPPL2B/MAPK14/EIF5A/OCLN/HSPA1A/YBX3 18 GO:0006949 syncytium formation 5/1115 57/18722 0.251065720206094 0.506399652504849 MAPK14/CFLAR/SH3PXD2A/MYOF/ERVW-1 5 GO:0061756 leukocyte adhesion to vascular endothelial cell 5/1115 57/18722 0.251065720206094 0.506399652504849 ITGB1/NFAT5/ROCK1/ZDHHC21/RHOA 5 GO:0097120 receptor localization to synapse 5/1115 57/18722 0.251065720206094 0.506399652504849 DAG1/ADAM10/DLG1/CLSTN1/KIF5B 5 GO:0051650 establishment of vesicle localization 12/1115 161/18722 0.252022495268001 0.507074556676256 MYO1C/TRIP11/ACTN4/CCDC186/DYNC1H1/KIF5B/WASL/MYO7A/CLN3/TRAK2/MYO6/CTNNB1 12 GO:0006284 base-excision repair 4/1115 43/18722 0.252350083740179 0.507074556676256 RPS3/USP47/HMGB1/TDG 4 GO:0021983 pituitary gland development 4/1115 43/18722 0.252350083740179 0.507074556676256 CDH1/RBPJ/BMPR1A/ISL1 4 GO:0031952 regulation of protein autophosphorylation 4/1115 43/18722 0.252350083740179 0.507074556676256 IQGAP1/CALM1/PDGFD/CAV1 4 GO:0034661 ncRNA catabolic process 4/1115 43/18722 0.252350083740179 0.507074556676256 DICER1/KCNQ1OT1/XRN1/SND1 4 GO:0045840 positive regulation of mitotic nuclear division 4/1115 43/18722 0.252350083740179 0.507074556676256 LRP5/PHIP/INSR/NUSAP1 4 GO:0045981 positive regulation of nucleotide metabolic process 4/1115 43/18722 0.252350083740179 0.507074556676256 APP/ENO1/TMSB4X/INSR 4 GO:0046636 negative regulation of alpha-beta T cell activation 4/1115 43/18722 0.252350083740179 0.507074556676256 ANXA1/GLI3/HMGB1/RC3H1 4 GO:1900544 positive regulation of purine nucleotide metabolic process 4/1115 43/18722 0.252350083740179 0.507074556676256 APP/ENO1/TMSB4X/INSR 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/1115 43/18722 0.252350083740179 0.507074556676256 GNA12/GSTP1/S1PR2/RHOA 4 GO:0046939 nucleotide phosphorylation 8/1115 101/18722 0.253423726642498 0.509040359873701 GAPDH/LDHA/APP/ALDOA/NCOR1/ENO1/TPI1/INSR 8 GO:0016053 organic acid biosynthetic process 22/1115 316/18722 0.253782274341721 0.509568846449961 ANXA1/HACD3/SLC27A2/ATP2B4/MIF/CD74/ACSS1/PTGES3/BCAT1/GSTP1/SERINC3/SLC1A3/DEGS1/MTR/TECR/CLN3/ABCD3/ALDH18A1/ACSL3/BCAT2/ELOVL1/FASN 22 GO:0019079 viral genome replication 10/1115 131/18722 0.254017940451943 0.509658693751568 HACD3/PPIA/EEA1/PKN2/DDB1/PCBP2/MPHOSPH8/TOP2B/STOM/MAVS 10 GO:1904950 negative regulation of establishment of protein localization 10/1115 131/18722 0.254017940451943 0.509658693751568 ANXA1/LMAN1/ERLEC1/FERMT1/FRMD4A/LYPLA1/PPP3CA/REST/DNAJA1/RHBDF1 10 GO:1990748 cellular detoxification 9/1115 116/18722 0.254167802001461 0.509767804239595 PRDX1/BMP7/PRDX4/GPX3/GSTP1/GPX8/CAT/PRDX3/SOD1 9 GO:0051648 vesicle localization 13/1115 177/18722 0.256802625849194 0.514858888249662 MYO1C/USO1/TRIP11/ACTN4/CCDC186/DYNC1H1/KIF5B/WASL/MYO7A/CLN3/TRAK2/MYO6/CTNNB1 13 GO:0030032 lamellipodium assembly 6/1115 72/18722 0.257353005915589 0.515381732401849 ITGB1/NCKAP1/VAV3/ABI2/OCLN/WASF2 6 GO:0070227 lymphocyte apoptotic process 6/1115 72/18722 0.257353005915589 0.515381732401849 RPS6/SLC39A10/CD74/DOCK8/GLI3/FOXP1 6 GO:1901880 negative regulation of protein depolymerization 6/1115 72/18722 0.257353005915589 0.515381732401849 SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/CAMSAP2 6 GO:0032259 methylation 25/1115 364/18722 0.257800788542603 0.516084893149216 ASH1L/ATRX/METTL7A/BRD4/KMT2C/DNMT3A/TET2/RIF1/ZC3H13/NSD1/RAB6A/MPHOSPH8/PRMT9/JARID2/MTR/RNMT/SETD2/KMT2A/PCMTD1/SUZ12/ATF7IP/TARBP1/CREBBP/CTNNB1/SNRPB 25 GO:0060759 regulation of response to cytokine stimulus 12/1115 162/18722 0.258666604157254 0.517624062816933 SPPL2A/CD74/HSP90AB1/GSTP1/TRIM44/PARP14/ADAM17/SPPL2B/CAV1/AGPAT1/MAVS/HSPA1A 12 GO:0034765 regulation of ion transmembrane transport 33/1115 491/18722 0.259185835706338 0.518468781130063 AHNAK/AKAP9/TCAF1/ITGB1/UTRN/APP/ATP2B4/SLC43A2/CALM1/ANO6/ANK3/ARL6IP5/YWHAE/SLC9A1/DLG1/ACTN4/C4orf3/KCNN4/TMEM37/KIF5B/VDAC1/AHCYL1/GJA5/GPD1L/DMD/WNK1/TMSB4X/CAV1/STOM/ALG10B/CLIC3/PKD2/VMP1 33 GO:1904063 negative regulation of cation transmembrane transport 8/1115 102/18722 0.261915150860183 0.523732206158246 SLC43A2/CALM1/ANK3/YWHAE/C4orf3/VDAC1/CAV1/PKD2 8 GO:0002763 positive regulation of myeloid leukocyte differentiation 5/1115 58/18722 0.262503371994021 0.523734752349236 ZFP36L1/CD74/ATP6AP1/KLF10/TMEM64 5 GO:0002931 response to ischemia 5/1115 58/18722 0.262503371994021 0.523734752349236 GJA1/P2RX4/CPEB4/CAV1/REST 5 GO:0034340 response to type I interferon 5/1115 58/18722 0.262503371994021 0.523734752349236 HSP90AB1/TRIM56/SMPD1/SETD2/MAVS 5 GO:0045604 regulation of epidermal cell differentiation 5/1115 58/18722 0.262503371994021 0.523734752349236 ZFP36L1/NCOA3/SGPP1/ROCK1/ESRP1 5 GO:0048015 phosphatidylinositol-mediated signaling 13/1115 178/18722 0.263185967663353 0.523734752349236 EGFR/FLT1/IGF1R/ZFP36L1/PLXNB1/NF1/ERBB3/FN1/PDGFD/PIK3IP1/INSR/CAT/ERBB2 13 GO:0015980 energy derivation by oxidation of organic compounds 22/1115 318/18722 0.263254353374636 0.523734752349236 IL6ST/AGL/GAA/COX6A1/PLEC/PTGES3/PHKB/IL10RB/RB1CC1/IREB2/CHCHD2/EPM2AIP1/SORBS1/TRPV4/HMGB1/OPN3/INSR/IDH1/CAT/CYCS/RHOA/UQCRH 22 GO:0003299 muscle hypertrophy in response to stress 3/1115 30/18722 0.26387834497461 0.523734752349236 ATP2B4/ATP2A2/PPP3CA 3 GO:0014887 cardiac muscle adaptation 3/1115 30/18722 0.26387834497461 0.523734752349236 ATP2B4/ATP2A2/PPP3CA 3 GO:0014898 cardiac muscle hypertrophy in response to stress 3/1115 30/18722 0.26387834497461 0.523734752349236 ATP2B4/ATP2A2/PPP3CA 3 GO:0019674 NAD metabolic process 3/1115 30/18722 0.26387834497461 0.523734752349236 LDHA/ENO1/GPD1L 3 GO:0030204 chondroitin sulfate metabolic process 3/1115 30/18722 0.26387834497461 0.523734752349236 CHPF/DSE/CHST11 3 GO:0033137 negative regulation of peptidyl-serine phosphorylation 3/1115 30/18722 0.26387834497461 0.523734752349236 GPD1L/DMD/CAV1 3 GO:0036296 response to increased oxygen levels 3/1115 30/18722 0.26387834497461 0.523734752349236 ATP6AP1/CAV1/CAT 3 GO:0045939 negative regulation of steroid metabolic process 3/1115 30/18722 0.26387834497461 0.523734752349236 ATP1A1/REST/SOD1 3 GO:0048147 negative regulation of fibroblast proliferation 3/1115 30/18722 0.26387834497461 0.523734752349236 FTH1/NF1/GSTP1 3 GO:0051491 positive regulation of filopodium assembly 3/1115 30/18722 0.26387834497461 0.523734752349236 NRP1/TGFBR1/WASL 3 GO:0060218 hematopoietic stem cell differentiation 3/1115 30/18722 0.26387834497461 0.523734752349236 N4BP2L2/PRKDC/UFL1 3 GO:0060351 cartilage development involved in endochondral bone morphogenesis 3/1115 30/18722 0.26387834497461 0.523734752349236 TRIP11/TRPV4/TSKU 3 GO:0060603 mammary gland duct morphogenesis 3/1115 30/18722 0.26387834497461 0.523734752349236 LRP5/DDR1/FGFR2 3 GO:2000648 positive regulation of stem cell proliferation 3/1115 30/18722 0.26387834497461 0.523734752349236 N4BP2L2/GJA1/LTBP3 3 GO:0061025 membrane fusion 12/1115 163/18722 0.265371104984537 0.525186960785407 ANXA1/EEA1/USO1/FOLR1/SYT7/KIF5B/YIPF4/VAV3/CLN3/RAB13/MYOF/ANXA2 12 GO:0002066 columnar/cuboidal epithelial cell development 4/1115 44/18722 0.265677127636219 0.525186960785407 IL6ST/CDK6/FASN/GPAT4 4 GO:0007528 neuromuscular junction development 4/1115 44/18722 0.265677127636219 0.525186960785407 APP/COL4A1/ANK3/ERBB2 4 GO:0042554 superoxide anion generation 4/1115 44/18722 0.265677127636219 0.525186960785407 EGFR/GSTP1/SH3PXD2A/SOD1 4 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 4/1115 44/18722 0.265677127636219 0.525186960785407 CSH1/PRLR/IL10RB/OCIAD2 4 GO:0060324 face development 4/1115 44/18722 0.265677127636219 0.525186960785407 NIPBL/ANKRD11/RAB3GAP1/ARID5B 4 GO:0097178 ruffle assembly 4/1115 44/18722 0.265677127636219 0.525186960785407 KANK1/PFN1/COBL/CAV1 4 GO:0006364 rRNA processing 16/1115 225/18722 0.267166171276558 0.525186960785407 RPL7/RPS6/RPL5/RPS8/RPS16/RPL7A/RPL14/PRKDC/DDX17/RPS17/RPL26/RPS21/RPS25/RPL10A/RPL35/RPL27 16 GO:0050670 regulation of lymphocyte proliferation 16/1115 225/18722 0.267166171276558 0.525186960785407 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/DLG5/DLG1/TFRC/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 16 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 6/1115 73/18722 0.26756954399535 0.525186960785407 LRP1/LRP5/DYNLL1/CCDC186/KIF5B/EFNA5 6 GO:0045739 positive regulation of DNA repair 6/1115 73/18722 0.26756954399535 0.525186960785407 EGFR/PRKDC/RPS3/RIF1/HMGB1/FUS 6 GO:0051865 protein autoubiquitination 6/1115 73/18722 0.26756954399535 0.525186960785407 HECTD1/RNF13/AMFR/LTN1/RNF213/TRIM13 6 GO:0070988 demethylation 6/1115 73/18722 0.26756954399535 0.525186960785407 TET2/USP9X/JMJD1C/KDM5A/JARID2/TDG 6 GO:1901214 regulation of neuron death 22/1115 319/18722 0.268041563578503 0.525186960785407 LRP1/GRN/NRP1/LGMN/NF1/ERBB3/SERPINF1/HSP90AB1/RASA1/PRKCI/TMEM259/CPEB4/DHCR24/CLN3/OXR1/REL/REST/ISL1/CTNNB1/WFS1/RHOA/SOD1 22 GO:0001780 neutrophil homeostasis 2/1115 17/18722 0.268839850875917 0.525186960785407 ANXA1/HMGB1 2 GO:0003184 pulmonary valve morphogenesis 2/1115 17/18722 0.268839850875917 0.525186960785407 JAG1/GJA5 2 GO:0006577 amino-acid betaine metabolic process 2/1115 17/18722 0.268839850875917 0.525186960785407 CROT/CPT2 2 GO:0007379 segment specification 2/1115 17/18722 0.268839850875917 0.525186960785407 COBL/IRX2 2 GO:0009084 glutamine family amino acid biosynthetic process 2/1115 17/18722 0.268839850875917 0.525186960785407 CLN3/ALDH18A1 2 GO:0010612 regulation of cardiac muscle adaptation 2/1115 17/18722 0.268839850875917 0.525186960785407 ATP2B4/PPP3CA 2 GO:0010934 macrophage cytokine production 2/1115 17/18722 0.268839850875917 0.525186960785407 CD74/SEMA7A 2 GO:0010935 regulation of macrophage cytokine production 2/1115 17/18722 0.268839850875917 0.525186960785407 CD74/SEMA7A 2 GO:0015867 ATP transport 2/1115 17/18722 0.268839850875917 0.525186960785407 GJA1/CD47 2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 2/1115 17/18722 0.268839850875917 0.525186960785407 ERAP1/TAPBP 2 GO:0021924 cell proliferation in external granule layer 2/1115 17/18722 0.268839850875917 0.525186960785407 SLC6A4/RERE 2 GO:0021930 cerebellar granule cell precursor proliferation 2/1115 17/18722 0.268839850875917 0.525186960785407 SLC6A4/RERE 2 GO:0033151 V(D)J recombination 2/1115 17/18722 0.268839850875917 0.525186960785407 PRKDC/HMGB1 2 GO:0035518 histone H2A monoubiquitination 2/1115 17/18722 0.268839850875917 0.525186960785407 DDB1/SKP1 2 GO:0043117 positive regulation of vascular permeability 2/1115 17/18722 0.268839850875917 0.525186960785407 TRPV4/OCLN 2 GO:0043968 histone H2A acetylation 2/1115 17/18722 0.268839850875917 0.525186960785407 MORF4L2/MORF4L1 2 GO:0045815 positive regulation of gene expression, epigenetic 2/1115 17/18722 0.268839850875917 0.525186960785407 ARID1A/SERTAD2 2 GO:0048339 paraxial mesoderm development 2/1115 17/18722 0.268839850875917 0.525186960785407 SMAD2/BMPR1A 2 GO:0060263 regulation of respiratory burst 2/1115 17/18722 0.268839850875917 0.525186960785407 GRN/INSR 2 GO:0070293 renal absorption 2/1115 17/18722 0.268839850875917 0.525186960785407 CLDN4/MAGED2 2 GO:0071816 tail-anchored membrane protein insertion into ER membrane 2/1115 17/18722 0.268839850875917 0.525186960785407 EMC1/EMC10 2 GO:0072673 lamellipodium morphogenesis 2/1115 17/18722 0.268839850875917 0.525186960785407 KANK1/WASF2 2 GO:0090136 epithelial cell-cell adhesion 2/1115 17/18722 0.268839850875917 0.525186960785407 ITGB5/DSP 2 GO:1900034 regulation of cellular response to heat 2/1115 17/18722 0.268839850875917 0.525186960785407 CREBBP/ATM 2 GO:1902358 sulfate transmembrane transport 2/1115 17/18722 0.268839850875917 0.525186960785407 SLC26A2/SLC13A4 2 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 2/1115 17/18722 0.268839850875917 0.525186960785407 ATP2B4/PPP3CA 2 GO:1903358 regulation of Golgi organization 2/1115 17/18722 0.268839850875917 0.525186960785407 AKAP9/CAMSAP2 2 GO:1904262 negative regulation of TORC1 signaling 2/1115 17/18722 0.268839850875917 0.525186960785407 ITFG2/ATM 2 GO:2000811 negative regulation of anoikis 2/1115 17/18722 0.268839850875917 0.525186960785407 ITGB1/CAV1 2 GO:0010950 positive regulation of endopeptidase activity 13/1115 179/18722 0.269623995918592 0.52652615735529 LGMN/ASPH/CTSD/RPS3/ARL6IP5/NCSTN/HMGB1/CFLAR/REST/CYFIP2/CYCS/HSPE1/RHOA 13 GO:0071346 cellular response to interferon-gamma 9/1115 118/18722 0.27006203620307 0.52718874270135 GAPDH/RPL13A/ACTG1/HSP90AB1/MYO1C/CD47/KIF5B/PARP14/TLR3 9 GO:0032760 positive regulation of tumor necrosis factor production 8/1115 103/18722 0.270490226815342 0.527831623160493 APP/MIF/FZD5/HSPB1/HMGB1/TLR3/ISL1/MAVS 8 GO:0033013 tetrapyrrole metabolic process 5/1115 59/18722 0.27405764094727 0.534402390437353 SLC11A2/LMBRD1/IREB2/MTR/NFE2L1 5 GO:0051568 histone H3-K4 methylation 5/1115 59/18722 0.27405764094727 0.534402390437353 ASH1L/KMT2C/TET2/KMT2A/CTNNB1 5 GO:0016525 negative regulation of angiogenesis 11/1115 149/18722 0.274450574880715 0.534973208940539 COL4A2/SEMA6A/ATP2B4/SERPINF1/ADAMTS1/ROCK1/GTF2I/AMOT/PTPRM/FOXO4/CTNNB1 11 GO:0009150 purine ribonucleotide metabolic process 25/1115 368/18722 0.275685444529716 0.537184156329984 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RAN/ACSL3/INSR/PDE10A/PDE7A/ELOVL1/FASN/GPAT4/RHOA 25 GO:0042593 glucose homeostasis 18/1115 258/18722 0.277211632405483 0.539199342720267 LRP1/LRP5/IGF1R/RPS6/DYNLL1/FAM3B/SERPINF1/CCDC186/SLC16A1/TCF7L2/KIF5B/SLC29A1/TRPV4/INSR/EFNA5/PPP3CA/TRA2B/WFS1 18 GO:0006635 fatty acid beta-oxidation 6/1115 74/18722 0.277885078725243 0.539199342720267 SLC27A2/CROT/ECHDC2/CPT2/ABCD3/ACOX1 6 GO:0006801 superoxide metabolic process 6/1115 74/18722 0.277885078725243 0.539199342720267 EGFR/PRDX1/BMP7/GSTP1/SH3PXD2A/SOD1 6 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 6/1115 74/18722 0.277885078725243 0.539199342720267 NCOR1/UFL1/SKP2/FOXP1/ISL1/RHOA 6 GO:0046470 phosphatidylcholine metabolic process 6/1115 74/18722 0.277885078725243 0.539199342720267 SLC44A2/CDS1/SLC44A1/ACSL3/LPCAT3/GPAT4 6 GO:0032944 regulation of mononuclear cell proliferation 16/1115 227/18722 0.278705558672986 0.539199342720267 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/DLG5/DLG1/TFRC/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 16 GO:0003254 regulation of membrane depolarization 4/1115 45/18722 0.279128601687283 0.539199342720267 ANK3/IFI6/GJA5/GPD1L 4 GO:0030835 negative regulation of actin filament depolymerization 4/1115 45/18722 0.279128601687283 0.539199342720267 SCIN/SPTBN1/ADD3/SPTAN1 4 GO:0035384 thioester biosynthetic process 4/1115 45/18722 0.279128601687283 0.539199342720267 ACSS1/TECR/ACSL3/ELOVL1 4 GO:0045933 positive regulation of muscle contraction 4/1115 45/18722 0.279128601687283 0.539199342720267 ENO1/ATP1A1/TRPV4/RHOA 4 GO:0071616 acyl-CoA biosynthetic process 4/1115 45/18722 0.279128601687283 0.539199342720267 ACSS1/TECR/ACSL3/ELOVL1 4 GO:2000273 positive regulation of signaling receptor activity 4/1115 45/18722 0.279128601687283 0.539199342720267 ITGB1/NRP1/NCOA3/ADAM17 4 GO:0032006 regulation of TOR signaling 8/1115 104/18722 0.279143558762911 0.539199342720267 GNA12/SLC38A9/RICTOR/C9orf72/AKT3/TMEM127/ITFG2/ATM 8 GO:0032963 collagen metabolic process 8/1115 104/18722 0.279143558762911 0.539199342720267 ITGB1/CTSB/FURIN/P3H1/P3H2/SUCO/MMP15/TRAM2 8 GO:1901890 positive regulation of cell junction assembly 8/1115 104/18722 0.279143558762911 0.539199342720267 IQGAP1/NRP1/DLG5/ROCK1/CLSTN1/TPBG/S100A10/CAV1 8 GO:0051781 positive regulation of cell division 7/1115 89/18722 0.279246208345369 0.539199342720267 YBX1/PKN2/PDGFD/GAREM1/FGFR2/CAT/RHOA 7 GO:0022408 negative regulation of cell-cell adhesion 14/1115 196/18722 0.279430273163877 0.539199342720267 CDH1/ANXA1/CD74/DLG5/DLG1/JAG1/WNK1/TRPV4/GLI3/MIA3/C1QTNF1/HMGB1/RC3H1/ERBB2 14 GO:0090276 regulation of peptide hormone secretion 14/1115 196/18722 0.279430273163877 0.539199342720267 EGFR/LRP1/LRP5/DPP4/DYNLL1/GJA1/SYT7/SLC16A1/TCF7L2/KIF5B/EFNA5/PPP3CA/REST/ISL1 14 GO:0006066 alcohol metabolic process 24/1115 353/18722 0.279529825731778 0.539199342720267 LRP5/ABCA1/APP/ASAH1/PLPP3/SLC5A3/ACSS1/SGPP1/VLDLR/TPI1/NPC1/SMPD1/SPTLC3/DHCR24/NFE2L1/TSKU/SREBF2/LPCAT3/ISYNA1/REST/DHRS3/IDH1/CAT/SOD1 24 GO:0002063 chondrocyte development 3/1115 31/18722 0.280355380294336 0.539199342720267 CHST11/BMPR2/TSKU 3 GO:0006301 postreplication repair 3/1115 31/18722 0.280355380294336 0.539199342720267 REV3L/USP10/USP43 3 GO:0006779 porphyrin-containing compound biosynthetic process 3/1115 31/18722 0.280355380294336 0.539199342720267 SLC11A2/IREB2/NFE2L1 3 GO:0016577 histone demethylation 3/1115 31/18722 0.280355380294336 0.539199342720267 JMJD1C/KDM5A/JARID2 3 GO:0031114 regulation of microtubule depolymerization 3/1115 31/18722 0.280355380294336 0.539199342720267 TAOK1/TRPV4/CAMSAP2 3 GO:0032148 activation of protein kinase B activity 3/1115 31/18722 0.280355380294336 0.539199342720267 PPIA/OSBPL8/INSR 3 GO:0033014 tetrapyrrole biosynthetic process 3/1115 31/18722 0.280355380294336 0.539199342720267 SLC11A2/IREB2/NFE2L1 3 GO:0035510 DNA dealkylation 3/1115 31/18722 0.280355380294336 0.539199342720267 TET2/USP9X/TDG 3 GO:0042133 neurotransmitter metabolic process 3/1115 31/18722 0.280355380294336 0.539199342720267 SLC6A4/CLN3/GCHFR 3 GO:0048384 retinoic acid receptor signaling pathway 3/1115 31/18722 0.280355380294336 0.539199342720267 ESRRG/ACTN4/DHRS3 3 GO:0048566 embryonic digestive tract development 3/1115 31/18722 0.280355380294336 0.539199342720267 NIPBL/GLI3/FGFR2 3 GO:0065005 protein-lipid complex assembly 3/1115 31/18722 0.280355380294336 0.539199342720267 ABCA1/ACSL3/LPCAT3 3 GO:0071480 cellular response to gamma radiation 3/1115 31/18722 0.280355380294336 0.539199342720267 RPL26/HSPA5/ATM 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/1115 31/18722 0.280355380294336 0.539199342720267 MIF/CD74/RRM2B 3 GO:1905144 response to acetylcholine 3/1115 31/18722 0.280355380294336 0.539199342720267 ATP2B4/GNAQ/LY6E 3 GO:1905145 cellular response to acetylcholine 3/1115 31/18722 0.280355380294336 0.539199342720267 ATP2B4/GNAQ/LY6E 3 GO:2000144 positive regulation of DNA-templated transcription, initiation 3/1115 31/18722 0.280355380294336 0.539199342720267 MED13/DHX36/SUB1 3 GO:0009914 hormone transport 21/1115 306/18722 0.281561487774714 0.541324012686063 EGFR/LRP1/ANXA1/LRP5/DPP4/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/TRPV4/SMAD2/C1QTNF1/SLC16A2/EFNA5/PPP3CA/REST/ISL1 21 GO:0033500 carbohydrate homeostasis 18/1115 259/18722 0.282662824743162 0.543245796005667 LRP1/LRP5/IGF1R/RPS6/DYNLL1/FAM3B/SERPINF1/CCDC186/SLC16A1/TCF7L2/KIF5B/SLC29A1/TRPV4/INSR/EFNA5/PPP3CA/TRA2B/WFS1 18 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 5/1115 60/18722 0.285715040754614 0.548125261440491 PUM2/PUM1/XIAP/ANKRD17/HSPA1A 5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 5/1115 60/18722 0.285715040754614 0.548125261440491 USP47/TAOK1/TAOK3/FOXO4/ATM 5 GO:0033866 nucleoside bisphosphate biosynthetic process 5/1115 60/18722 0.285715040754614 0.548125261440491 SLC26A2/ACSS1/TECR/ACSL3/ELOVL1 5 GO:0034030 ribonucleoside bisphosphate biosynthetic process 5/1115 60/18722 0.285715040754614 0.548125261440491 SLC26A2/ACSS1/TECR/ACSL3/ELOVL1 5 GO:0034033 purine nucleoside bisphosphate biosynthetic process 5/1115 60/18722 0.285715040754614 0.548125261440491 SLC26A2/ACSS1/TECR/ACSL3/ELOVL1 5 GO:0040029 regulation of gene expression, epigenetic 8/1115 105/18722 0.287869713119867 0.549018469874062 XIST/TPR/DNMT3A/ARID1A/MPHOSPH8/SERTAD2/ATF7IP/TDG 8 GO:0006094 gluconeogenesis 6/1115 75/18722 0.288290195105941 0.549018469874062 RANBP2/DDB1/TPI1/SLC35B4/SOGA1/G6PC3 6 GO:0034121 regulation of toll-like receptor signaling pathway 6/1115 75/18722 0.288290195105941 0.549018469874062 LGR4/RTN4/HMGB1/CAV1/APPL1/TLR3 6 GO:0043627 response to estrogen 6/1115 75/18722 0.288290195105941 0.549018469874062 KRT19/LDHA/GLI3/CAV1/CCND1/SERPINB9 6 GO:0045913 positive regulation of carbohydrate metabolic process 6/1115 75/18722 0.288290195105941 0.549018469874062 APP/DDB1/EPM2AIP1/SORBS1/HMGB1/INSR 6 GO:0048662 negative regulation of smooth muscle cell proliferation 6/1115 75/18722 0.288290195105941 0.549018469874062 SF1/GNA12/GSTP1/BMPR2/S1PR2/RHOA 6 GO:2001259 positive regulation of cation channel activity 6/1115 75/18722 0.288290195105941 0.549018469874062 CALM1/ANK3/KIF5B/TMSB4X/ALG10B/PKD2 6 GO:0048477 oogenesis 7/1115 90/18722 0.288711866711076 0.549018469874062 LGR5/RPS6/DIAPH2/HEXB/ZFX/PAQR7/CTNNB1 7 GO:0097581 lamellipodium organization 7/1115 90/18722 0.288711866711076 0.549018469874062 ITGB1/KANK1/NCKAP1/VAV3/ABI2/OCLN/WASF2 7 GO:0043535 regulation of blood vessel endothelial cell migration 11/1115 151/18722 0.288886746311708 0.549018469874062 ANXA1/NRP1/ATP2B4/NF1/P2RX4/ADAM17/TMSB4X/HSPB1/AKT3/HMGB1/RHOA 11 GO:0071333 cellular response to glucose stimulus 11/1115 151/18722 0.288886746311708 0.549018469874062 LRP1/LRP5/IGF1R/DYNLL1/SERPINF1/CCDC186/KIF5B/SLC29A1/EFNA5/PPP3CA/TRA2B 11 GO:2000181 negative regulation of blood vessel morphogenesis 11/1115 151/18722 0.288886746311708 0.549018469874062 COL4A2/SEMA6A/ATP2B4/SERPINF1/ADAMTS1/ROCK1/GTF2I/AMOT/PTPRM/FOXO4/CTNNB1 11 GO:0048017 inositol lipid-mediated signaling 13/1115 182/18722 0.289244302298941 0.549018469874062 EGFR/FLT1/IGF1R/ZFP36L1/PLXNB1/NF1/ERBB3/FN1/PDGFD/PIK3IP1/INSR/CAT/ERBB2 13 GO:0071356 cellular response to tumor necrosis factor 16/1115 229/18722 0.29041006239249 0.549018469874062 KRT8/ASAH1/SPPL2A/ZFP36L1/RPS3/KRT18/ACTN4/GSTP1/ADAM17/TMSB4X/SPPL2B/MAPK14/EIF5A/OCLN/HSPA1A/YBX3 16 GO:0006337 nucleosome disassembly 2/1115 18/18722 0.291425050313372 0.549018469874062 ARID1A/SMARCC1 2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process 2/1115 18/18722 0.291425050313372 0.549018469874062 ALG2/ALG10B 2 GO:0008272 sulfate transport 2/1115 18/18722 0.291425050313372 0.549018469874062 SLC26A2/SLC13A4 2 GO:0021534 cell proliferation in hindbrain 2/1115 18/18722 0.291425050313372 0.549018469874062 SLC6A4/RERE 2 GO:0030728 ovulation 2/1115 18/18722 0.291425050313372 0.549018469874062 ADAMTS1/HPGD 2 GO:0030730 sequestering of triglyceride 2/1115 18/18722 0.291425050313372 0.549018469874062 PLIN2/OSBPL8 2 GO:0030889 negative regulation of B cell proliferation 2/1115 18/18722 0.291425050313372 0.549018469874062 RC3H1/ATM 2 GO:0031643 positive regulation of myelination 2/1115 18/18722 0.291425050313372 0.549018469874062 DAG1/DICER1 2 GO:0031649 heat generation 2/1115 18/18722 0.291425050313372 0.549018469874062 ADRB1/EDNRB 2 GO:0032305 positive regulation of icosanoid secretion 2/1115 18/18722 0.291425050313372 0.549018469874062 P2RX4/PLA2R1 2 GO:0032769 negative regulation of monooxygenase activity 2/1115 18/18722 0.291425050313372 0.549018469874062 ATP2B4/CAV1 2 GO:0033189 response to vitamin A 2/1115 18/18722 0.291425050313372 0.549018469874062 DNMT3A/CAT 2 GO:0034162 toll-like receptor 9 signaling pathway 2/1115 18/18722 0.291425050313372 0.549018469874062 RTN4/HMGB1 2 GO:0045623 negative regulation of T-helper cell differentiation 2/1115 18/18722 0.291425050313372 0.549018469874062 ANXA1/RC3H1 2 GO:0048268 clathrin coat assembly 2/1115 18/18722 0.291425050313372 0.549018469874062 CLTC/CLTA 2 GO:0050665 hydrogen peroxide biosynthetic process 2/1115 18/18722 0.291425050313372 0.549018469874062 ACOX1/SOD1 2 GO:0060008 Sertoli cell differentiation 2/1115 18/18722 0.291425050313372 0.549018469874062 ATRX/RAB13 2 GO:0060192 negative regulation of lipase activity 2/1115 18/18722 0.291425050313372 0.549018469874062 ANXA1/PLA2R1 2 GO:0060546 negative regulation of necroptotic process 2/1115 18/18722 0.291425050313372 0.549018469874062 CAV1/YBX3 2 GO:0060716 labyrinthine layer blood vessel development 2/1115 18/18722 0.291425050313372 0.549018469874062 FZD5/RBPJ 2 GO:0060749 mammary gland alveolus development 2/1115 18/18722 0.291425050313372 0.549018469874062 DDR1/CCND1 2 GO:0060973 cell migration involved in heart development 2/1115 18/18722 0.291425050313372 0.549018469874062 BMP7/FOLR1 2 GO:0061377 mammary gland lobule development 2/1115 18/18722 0.291425050313372 0.549018469874062 DDR1/CCND1 2 GO:0071071 regulation of phospholipid biosynthetic process 2/1115 18/18722 0.291425050313372 0.549018469874062 ACSL3/IDH1 2 GO:0071800 podosome assembly 2/1115 18/18722 0.291425050313372 0.549018469874062 ASAP1/RHOA 2 GO:0072079 nephron tubule formation 2/1115 18/18722 0.291425050313372 0.549018469874062 CTNNB1/IRX2 2 GO:0072234 metanephric nephron tubule development 2/1115 18/18722 0.291425050313372 0.549018469874062 LGR4/PKD2 2 GO:0080182 histone H3-K4 trimethylation 2/1115 18/18722 0.291425050313372 0.549018469874062 TET2/KMT2A 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/1115 18/18722 0.291425050313372 0.549018469874062 LGR4/MAGED1 2 GO:0097709 connective tissue replacement 2/1115 18/18722 0.291425050313372 0.549018469874062 ROCK1/PPP3CA 2 GO:1900242 regulation of synaptic vesicle endocytosis 2/1115 18/18722 0.291425050313372 0.549018469874062 CALM1/ROCK1 2 GO:1900424 regulation of defense response to bacterium 2/1115 18/18722 0.291425050313372 0.549018469874062 GRN/FOXP1 2 GO:1901673 regulation of mitotic spindle assembly 2/1115 18/18722 0.291425050313372 0.549018469874062 TPR/HSPA1A 2 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 2/1115 18/18722 0.291425050313372 0.549018469874062 SEMA6A/ATP2B4 2 GO:1902683 regulation of receptor localization to synapse 2/1115 18/18722 0.291425050313372 0.549018469874062 DAG1/ADAM10 2 GO:1903209 positive regulation of oxidative stress-induced cell death 2/1115 18/18722 0.291425050313372 0.549018469874062 REST/SOD1 2 GO:1904872 regulation of telomerase RNA localization to Cajal body 2/1115 18/18722 0.291425050313372 0.549018469874062 DCP2/CCT3 2 GO:0006909 phagocytosis 21/1115 308/18722 0.291660406022877 0.549268045063894 LRP1/MET/ITGB1/ANXA1/ITGAV/COLEC12/ABCA1/ANO6/KIAA1109/SYT7/CD47/CLCN3/MYO7A/VAV3/CLN3/HMGB1/RHOBTB1/APPL1/RAB31/SOD1/CDC42SE1 21 GO:0070663 regulation of leukocyte proliferation 17/1115 245/18722 0.292189390695059 0.54983731150802 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/DLG5/DLG1/GSTP1/TFRC/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 17 GO:0001974 blood vessel remodeling 4/1115 46/18722 0.292683581064954 0.54983731150802 JAG1/RBPJ/BMPR2/ACVR2B 4 GO:0032924 activin receptor signaling pathway 4/1115 46/18722 0.292683581064954 0.54983731150802 TGFBR1/BMPR2/SMAD2/ACVR2B 4 GO:0043616 keratinocyte proliferation 4/1115 46/18722 0.292683581064954 0.54983731150802 ZFP36L1/FERMT1/PTPRK/FGFR2 4 GO:0044818 mitotic G2/M transition checkpoint 4/1115 46/18722 0.292683581064954 0.54983731150802 TAOK1/TAOK3/FOXO4/ATM 4 GO:0070828 heterochromatin organization 4/1115 46/18722 0.292683581064954 0.54983731150802 TPR/DNMT3A/MPHOSPH8/ATF7IP 4 GO:2000107 negative regulation of leukocyte apoptotic process 4/1115 46/18722 0.292683581064954 0.54983731150802 SLC39A10/CD74/DOCK8/FOXP1 4 GO:0044242 cellular lipid catabolic process 15/1115 214/18722 0.294392294344397 0.552852782098042 LRP1/SLC27A2/ASAH1/HEXB/HEXA/GM2A/SMPD1/CROT/FUCA1/PLBD1/ECHDC2/CPT2/ABCD3/ACOX1/IDH1 15 GO:1901343 negative regulation of vasculature development 11/1115 152/18722 0.296185245096292 0.556024269890683 COL4A2/SEMA6A/ATP2B4/SERPINF1/ADAMTS1/ROCK1/GTF2I/AMOT/PTPRM/FOXO4/CTNNB1 11 GO:0016197 endosomal transport 16/1115 230/18722 0.296320351458443 0.556036671000193 ABCA1/EEA1/KIAA1109/CLTC/SNX18/GCC2/TMEM87A/RAB6A/CLN5/EVI5/RAB11FIP4/HEATR5A/RHOBTB3/CMTM6/RAB13/ITSN2 16 GO:0042116 macrophage activation 8/1115 106/18722 0.296663229191408 0.556036671000193 GRN/APP/MIF/CTSC/CD74/FOXP1/HMGB1/TLR3 8 GO:0045761 regulation of adenylate cyclase activity 3/1115 32/18722 0.296920874512371 0.556036671000193 AKAP9/NF1/EDNRB 3 GO:0045879 negative regulation of smoothened signaling pathway 3/1115 32/18722 0.296920874512371 0.556036671000193 HERC4/GLI3/GPC3 3 GO:0050685 positive regulation of mRNA processing 3/1115 32/18722 0.296920874512371 0.556036671000193 DHX36/TRA2B/NCL 3 GO:1901532 regulation of hematopoietic progenitor cell differentiation 3/1115 32/18722 0.296920874512371 0.556036671000193 N4BP2L2/PRKDC/DHX36 3 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3/1115 32/18722 0.296920874512371 0.556036671000193 ANXA1/HMGB1/RC3H1 3 GO:0055006 cardiac cell development 7/1115 91/18722 0.298250536580155 0.558330860729821 TGFBR3/PLEC/AKAP13/JAG1/BMPR1A/OBSL1/ISL1 7 GO:0042098 T cell proliferation 14/1115 199/18722 0.298443327661472 0.558495943352471 CD46/IL6ST/ANXA1/RPS6/RPS3/DOCK8/DLG5/DLG1/TFRC/NCSTN/HMGB1/RC3H1/ERBB2/CTNNB1 14 GO:0031100 animal organ regeneration 6/1115 76/18722 0.298775504754641 0.558530259063385 EGFR/RPS16/TGFBR3/GSTP1/GLI3/CCND1 6 GO:0045685 regulation of glial cell differentiation 6/1115 76/18722 0.298775504754641 0.558530259063385 SPINT1/DAG1/IL6ST/DICER1/NF1/CTNNB1 6 GO:2000379 positive regulation of reactive oxygen species metabolic process 6/1115 76/18722 0.298775504754641 0.558530259063385 EGFR/SLC5A3/GSTP1/CLCN3/MAPK14/SOD1 6 GO:0050671 positive regulation of lymphocyte proliferation 10/1115 137/18722 0.299521430527099 0.559728707589842 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/TFRC/VAV3/HMGB1 10 GO:0000070 mitotic sister chromatid segregation 12/1115 168/18722 0.299710946524487 0.559886894154736 NIPBL/ATRX/TPR/EML4/KPNB1/PDS5B/RAN/ZNF207/ATM/UBE2C/NUSAP1/CDC20 12 GO:2001257 regulation of cation channel activity 13/1115 184/18722 0.302557310282728 0.565006463658441 AHNAK/ITGB1/APP/CALM1/ANK3/DLG1/KIF5B/DMD/TMSB4X/CAV1/STOM/ALG10B/PKD2 13 GO:0071331 cellular response to hexose stimulus 11/1115 153/18722 0.303533265197346 0.566630805205814 LRP1/LRP5/IGF1R/DYNLL1/SERPINF1/CCDC186/KIF5B/SLC29A1/EFNA5/PPP3CA/TRA2B 11 GO:0032526 response to retinoic acid 8/1115 107/18722 0.305518629632779 0.569446807035914 ABCA1/SLC6A4/GJA1/SERPINF1/SUZ12/FGFR2/PTK7/ATM 8 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 8/1115 107/18722 0.305518629632779 0.569446807035914 APP/MIF/FZD5/HSPB1/HMGB1/TLR3/ISL1/MAVS 8 GO:0001754 eye photoreceptor cell differentiation 4/1115 47/18722 0.306321638847564 0.569446807035914 TUG1/PRKCI/MYO7A/NAGLU 4 GO:0001774 microglial cell activation 4/1115 47/18722 0.306321638847564 0.569446807035914 GRN/APP/CTSC/TLR3 4 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 4/1115 47/18722 0.306321638847564 0.569446807035914 MME/ADRB1/ENPEP/RHOA 4 GO:0010799 regulation of peptidyl-threonine phosphorylation 4/1115 47/18722 0.306321638847564 0.569446807035914 APP/CALM1/BMP7/S1PR2 4 GO:0016574 histone ubiquitination 4/1115 47/18722 0.306321638847564 0.569446807035914 UBR5/DDB1/TRIP12/SKP1 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/1115 47/18722 0.306321638847564 0.569446807035914 IQGAP1/JAG1/MTSS1/CTNNB1 4 GO:0045747 positive regulation of Notch signaling pathway 4/1115 47/18722 0.306321638847564 0.569446807035914 IL6ST/AAK1/JAG1/PRKCI 4 GO:0047496 vesicle transport along microtubule 4/1115 47/18722 0.306321638847564 0.569446807035914 DYNC1H1/KIF5B/CLN3/TRAK2 4 GO:0101023 vascular endothelial cell proliferation 4/1115 47/18722 0.306321638847564 0.569446807035914 FLT1/ADAM17/AKT3/HMGB1 4 GO:1905562 regulation of vascular endothelial cell proliferation 4/1115 47/18722 0.306321638847564 0.569446807035914 FLT1/ADAM17/AKT3/HMGB1 4 GO:0046879 hormone secretion 20/1115 295/18722 0.306466040963963 0.569516948383779 EGFR/LRP1/ANXA1/LRP5/DPP4/DYNLL1/GJA1/FAM3B/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/TRPV4/SMAD2/C1QTNF1/EFNA5/PPP3CA/REST/ISL1 20 GO:0032946 positive regulation of mononuclear cell proliferation 10/1115 138/18722 0.307307217989579 0.570649080739963 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/TFRC/VAV3/HMGB1 10 GO:0007062 sister chromatid cohesion 5/1115 62/18722 0.30928596401959 0.570649080739963 NIPBL/ATRX/PDS5B/CTNNB1/CDC20 5 GO:0007588 excretion 5/1115 62/18722 0.30928596401959 0.570649080739963 NFAT5/ATP6V1B1/SLC22A18/CLN3/EDNRB 5 GO:0032731 positive regulation of interleukin-1 beta production 5/1115 62/18722 0.30928596401959 0.570649080739963 APP/FZD5/HSPB1/HMGB1/ISL1 5 GO:0032757 positive regulation of interleukin-8 production 5/1115 62/18722 0.30928596401959 0.570649080739963 CD74/HMGB1/TLR3/MAVS/HSPA1A 5 GO:0048663 neuron fate commitment 5/1115 62/18722 0.30928596401959 0.570649080739963 TGFBR1/RBPJ/GLI3/ESRP1/ISL1 5 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 5/1115 62/18722 0.30928596401959 0.570649080739963 LRP1/BMP7/TGFBR1/BMPR2/BMPR1A 5 GO:1902750 negative regulation of cell cycle G2/M phase transition 5/1115 62/18722 0.30928596401959 0.570649080739963 USP47/TAOK1/TAOK3/FOXO4/ATM 5 GO:0006367 transcription initiation from RNA polymerase II promoter 6/1115 77/18722 0.309331668689286 0.570649080739963 ZNF451/MED13/DHX36/HMGB1/ATF7IP/SUB1 6 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 18/1115 264/18722 0.310437580181294 0.570649080739963 EGFR/IL6ST/CSH1/IQGAP1/NRP1/APP/MIF/CD74/ERBB3/RICTOR/PARP14/ADAM17/PDGFD/CAV1/SUZ12/EFNA5/IBTK/ISL1 18 GO:0071326 cellular response to monosaccharide stimulus 11/1115 154/18722 0.310927713939433 0.570649080739963 LRP1/LRP5/IGF1R/DYNLL1/SERPINF1/CCDC186/KIF5B/SLC29A1/EFNA5/PPP3CA/TRA2B 11 GO:0031570 DNA integrity checkpoint signaling 9/1115 123/18722 0.310972135513821 0.570649080739963 PRKDC/RPL26/TAOK1/TAOK3/MAPK14/CCND1/FEM1B/FOXO4/ATM 9 GO:0051090 regulation of DNA-binding transcription factor activity 29/1115 440/18722 0.312035478635811 0.570649080739963 LRP5/NPM1/APP/PLPP3/PPIA/RPS3/BMP7/RPS6KA5/UFL1/TFRC/TCF7L2/KDM5A/PRKCI/TMSB4X/FZD6/CFLAR/CAV1/ARID5B/PKD2/PPP3CA/TLR3/TRIM38/CAT/MAVS/TRIM13/CTNNB1/HSPA1A/WFS1/PRDX3 29 GO:0002431 Fc receptor mediated stimulatory signaling pathway 3/1115 33/18722 0.313539430309888 0.570649080739963 CD47/VAV3/APPL1 3 GO:0006482 protein demethylation 3/1115 33/18722 0.313539430309888 0.570649080739963 JMJD1C/KDM5A/JARID2 3 GO:0006891 intra-Golgi vesicle-mediated transport 3/1115 33/18722 0.313539430309888 0.570649080739963 CUX1/COPA/RAB6A 3 GO:0008214 protein dealkylation 3/1115 33/18722 0.313539430309888 0.570649080739963 JMJD1C/KDM5A/JARID2 3 GO:0018345 protein palmitoylation 3/1115 33/18722 0.313539430309888 0.570649080739963 ZDHHC20/ZDHHC17/ZDHHC21 3 GO:0032228 regulation of synaptic transmission, GABAergic 3/1115 33/18722 0.313539430309888 0.570649080739963 KIF5B/NISCH/CLN3 3 GO:0033198 response to ATP 3/1115 33/18722 0.313539430309888 0.570649080739963 HSP90B1/P2RX4/SOD1 3 GO:0036336 dendritic cell migration 3/1115 33/18722 0.313539430309888 0.570649080739963 ANO6/DOCK8/HMGB1 3 GO:0045648 positive regulation of erythrocyte differentiation 3/1115 33/18722 0.313539430309888 0.570649080739963 PRKDC/MAPK14/HSPA1A 3 GO:0070570 regulation of neuron projection regeneration 3/1115 33/18722 0.313539430309888 0.570649080739963 LRP1/GRN/PTPRF 3 GO:0071539 protein localization to centrosome 3/1115 33/18722 0.313539430309888 0.570649080739963 GOLGB1/CEP350/PCM1 3 GO:1900181 negative regulation of protein localization to nucleus 3/1115 33/18722 0.313539430309888 0.570649080739963 MAGED1/FERMT1/LATS2 3 GO:1902275 regulation of chromatin organization 3/1115 33/18722 0.313539430309888 0.570649080739963 TPR/MPHOSPH8/ATF7IP 3 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 2/1115 19/18722 0.313915780133596 0.570649080739963 TTC37/DCP2 2 GO:0002281 macrophage activation involved in immune response 2/1115 19/18722 0.313915780133596 0.570649080739963 GRN/HMGB1 2 GO:0002483 antigen processing and presentation of endogenous peptide antigen 2/1115 19/18722 0.313915780133596 0.570649080739963 ERAP1/TAPBP 2 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 2/1115 19/18722 0.313915780133596 0.570649080739963 DHX36/MAVS 2 GO:0003085 negative regulation of systemic arterial blood pressure 2/1115 19/18722 0.313915780133596 0.570649080739963 ADRB1/BMPR2 2 GO:0006007 glucose catabolic process 2/1115 19/18722 0.313915780133596 0.570649080739963 LRP5/ENO1 2 GO:0006044 N-acetylglucosamine metabolic process 2/1115 19/18722 0.313915780133596 0.570649080739963 EXTL2/GNE 2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 2/1115 19/18722 0.313915780133596 0.570649080739963 ALG2/ALG10B 2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/1115 19/18722 0.313915780133596 0.570649080739963 RPL26/ATM 2 GO:0009081 branched-chain amino acid metabolic process 2/1115 19/18722 0.313915780133596 0.570649080739963 BCAT1/BCAT2 2 GO:0010885 regulation of cholesterol storage 2/1115 19/18722 0.313915780133596 0.570649080739963 ABCA1/SREBF2 2 GO:0032026 response to magnesium ion 2/1115 19/18722 0.313915780133596 0.570649080739963 ANK3/CCND1 2 GO:0033194 response to hydroperoxide 2/1115 19/18722 0.313915780133596 0.570649080739963 GPX3/OXR1 2 GO:0035313 wound healing, spreading of epidermal cells 2/1115 19/18722 0.313915780133596 0.570649080739963 FERMT1/ADAM17 2 GO:0042474 middle ear morphogenesis 2/1115 19/18722 0.313915780133596 0.570649080739963 RPL38/NAGLU 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/1115 19/18722 0.313915780133596 0.570649080739963 MPHOSPH8/TOP2B 2 GO:0045821 positive regulation of glycolytic process 2/1115 19/18722 0.313915780133596 0.570649080739963 APP/INSR 2 GO:0046782 regulation of viral transcription 2/1115 19/18722 0.313915780133596 0.570649080739963 RSF1/TRIM13 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/1115 19/18722 0.313915780133596 0.570649080739963 KMT2A/CTNNB1 2 GO:0051957 positive regulation of amino acid transport 2/1115 19/18722 0.313915780133596 0.570649080739963 ITGB1/RAB3GAP1 2 GO:0060065 uterus development 2/1115 19/18722 0.313915780133596 0.570649080739963 NIPBL/ASH1L 2 GO:0062099 negative regulation of programmed necrotic cell death 2/1115 19/18722 0.313915780133596 0.570649080739963 CAV1/YBX3 2 GO:0070989 oxidative demethylation 2/1115 19/18722 0.313915780133596 0.570649080739963 TET2/TDG 2 GO:0072074 kidney mesenchyme development 2/1115 19/18722 0.313915780133596 0.570649080739963 BMP7/PKD2 2 GO:0086014 atrial cardiac muscle cell action potential 2/1115 19/18722 0.313915780133596 0.570649080739963 GJA1/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/1115 19/18722 0.313915780133596 0.570649080739963 GJA1/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/1115 19/18722 0.313915780133596 0.570649080739963 GJA1/GJA5 2 GO:0090670 RNA localization to Cajal body 2/1115 19/18722 0.313915780133596 0.570649080739963 DCP2/CCT3 2 GO:0090671 telomerase RNA localization to Cajal body 2/1115 19/18722 0.313915780133596 0.570649080739963 DCP2/CCT3 2 GO:0090672 telomerase RNA localization 2/1115 19/18722 0.313915780133596 0.570649080739963 DCP2/CCT3 2 GO:0090685 RNA localization to nucleus 2/1115 19/18722 0.313915780133596 0.570649080739963 DCP2/CCT3 2 GO:0097623 potassium ion export across plasma membrane 2/1115 19/18722 0.313915780133596 0.570649080739963 ANO6/DLG1 2 GO:1900221 regulation of amyloid-beta clearance 2/1115 19/18722 0.313915780133596 0.570649080739963 LRP1/ROCK1 2 GO:1901739 regulation of myoblast fusion 2/1115 19/18722 0.313915780133596 0.570649080739963 MAPK14/CFLAR 2 GO:1901881 positive regulation of protein depolymerization 2/1115 19/18722 0.313915780133596 0.570649080739963 TRPV4/DSTN 2 GO:1903975 regulation of glial cell migration 2/1115 19/18722 0.313915780133596 0.570649080739963 LRP1/P2RX4 2 GO:1903978 regulation of microglial cell activation 2/1115 19/18722 0.313915780133596 0.570649080739963 GRN/CTSC 2 GO:2000738 positive regulation of stem cell differentiation 2/1115 19/18722 0.313915780133596 0.570649080739963 LTBP3/DHX36 2 GO:0033138 positive regulation of peptidyl-serine phosphorylation 8/1115 108/18722 0.314430430626197 0.571390084790083 EGFR/AKAP9/APP/ATP2B4/MIF/HSP90AB1/TFRC/CAV1 8 GO:0032755 positive regulation of interleukin-6 production 7/1115 93/18722 0.317518894769625 0.576609992916676 APP/CD74/TRPV4/HMGB1/TLR3/ISL1/MAVS 7 GO:1902807 negative regulation of cell cycle G1/S phase transition 7/1115 93/18722 0.317518894769625 0.576609992916676 PRKDC/RPL26/DLG1/JADE1/CCND1/PKD2/ATM 7 GO:0000819 sister chromatid segregation 14/1115 202/18722 0.317817964695241 0.576956856004043 NIPBL/ATRX/TPR/EML4/TOP2B/KPNB1/PDS5B/RAN/ZNF207/ATM/UBE2C/NUSAP1/CTNNB1/CDC20 14 GO:0019319 hexose biosynthetic process 6/1115 78/18722 0.319949418896641 0.579383607985432 RANBP2/DDB1/TPI1/SLC35B4/SOGA1/G6PC3 6 GO:0032024 positive regulation of insulin secretion 6/1115 78/18722 0.319949418896641 0.579383607985432 LRP1/DYNLL1/GJA1/TCF7L2/KIF5B/ISL1 6 GO:0002673 regulation of acute inflammatory response 4/1115 48/18722 0.320022899409822 0.579383607985432 IL6ST/ASH1L/GSTP1/EDNRB 4 GO:0002686 negative regulation of leukocyte migration 4/1115 48/18722 0.320022899409822 0.579383607985432 MIF/DPP4/MIA3/WASL 4 GO:0006111 regulation of gluconeogenesis 4/1115 48/18722 0.320022899409822 0.579383607985432 RANBP2/DDB1/SLC35B4/SOGA1 4 GO:0035036 sperm-egg recognition 4/1115 48/18722 0.320022899409822 0.579383607985432 ALDOA/B4GALT1/FOLR1/CCT3 4 GO:0045839 negative regulation of mitotic nuclear division 4/1115 48/18722 0.320022899409822 0.579383607985432 BMP7/TPR/ZNF207/ATM 4 GO:0120009 intermembrane lipid transfer 4/1115 48/18722 0.320022899409822 0.579383607985432 ABCA1/TTPA/PLEKHA8/OSBPL8 4 GO:0046890 regulation of lipid biosynthetic process 12/1115 171/18722 0.320875058741712 0.580678711781574 ANXA1/ASAH1/CD74/SF1/ORMDL1/SORBS1/ATP1A1/ACSL3/LPCAT3/REST/IDH1/SOD1 12 GO:0001756 somitogenesis 5/1115 63/18722 0.321173297600859 0.580678711781574 PRKDC/RBPJ/MIB1/COBL/BMPR1A 5 GO:0016239 positive regulation of macroautophagy 5/1115 63/18722 0.321173297600859 0.580678711781574 VDAC1/C9orf72/RAB3GAP1/RAB3GAP2/TRIM13 5 GO:0050854 regulation of antigen receptor-mediated signaling pathway 5/1115 63/18722 0.321173297600859 0.580678711781574 SLC39A10/RPS3/KCNN4/FOXP1/RC3H1 5 GO:1903532 positive regulation of secretion by cell 19/1115 282/18722 0.322204146393303 0.582345273389928 EGFR/LRP1/WLS/SLC6A4/DYNLL1/PPIA/GJA1/EXPH5/P2RX4/SYT7/KCNN4/ATP6AP1/TCF7L2/KIF5B/FRMD4A/MYH10/RAB3GAP1/C1QTNF1/ISL1 19 GO:0006821 chloride transport 8/1115 109/18722 0.323393151754395 0.584296459294997 SLC26A2/PCYOX1/GABRE/ANO6/SLC1A3/CLCN3/CLDN4/CLIC3 8 GO:0009267 cellular response to starvation 11/1115 156/18722 0.325843447116596 0.588524412772498 HNRNPA1/SLC2A1/SLC38A2/LAMP2/HSPA5/AOC1/KLF10/CPEB4/BMPR2/SREBF2/ITFG2 11 GO:0002042 cell migration involved in sprouting angiogenesis 7/1115 94/18722 0.327234633332246 0.590837236172087 ITGB1/ANXA1/NRP1/EPHB4/MIA3/AKT3/RHOA 7 GO:0018210 peptidyl-threonine modification 9/1115 125/18722 0.327713552625186 0.591361466905637 GALNT11/APP/CALM1/PRKDC/BMP7/ROCK1/TGFBR1/WNK1/S1PR2 9 GO:0051146 striated muscle cell differentiation 19/1115 283/18722 0.327746503197936 0.591361466905637 KRT19/ITGB1/KRT8/ACTG1/PLD3/YBX1/PLEC/MORF4L2/SLC9A1/AKAP13/RBPJ/MAPK14/CFLAR/MYOF/BMPR1A/OBSL1/PPP3CA/ERVW-1/ISL1 19 GO:0002221 pattern recognition receptor signaling pathway 12/1115 172/18722 0.328007196875905 0.591631900040695 COLEC12/LGR4/RTN4/PUM2/PUM1/HMGB1/CAV1/APPL1/XIAP/TLR3/ANKRD17/HSPA1A 12 GO:0001662 behavioral fear response 3/1115 34/18722 0.33017754885702 0.592344735667887 DPP4/GJA1/VDAC1 3 GO:0010614 negative regulation of cardiac muscle hypertrophy 3/1115 34/18722 0.33017754885702 0.592344735667887 ATP2B4/P2RX4/JARID2 3 GO:0019076 viral release from host cell 3/1115 34/18722 0.33017754885702 0.592344735667887 PPIA/DDB1/TRIM13 3 GO:0019320 hexose catabolic process 3/1115 34/18722 0.33017754885702 0.592344735667887 LRP5/GLB1/ENO1 3 GO:0032743 positive regulation of interleukin-2 production 3/1115 34/18722 0.33017754885702 0.592344735667887 ANXA1/RPS3/SPTBN1 3 GO:0034383 low-density lipoprotein particle clearance 3/1115 34/18722 0.33017754885702 0.592344735667887 LIPA/NCEH1/ANXA2 3 GO:0035137 hindlimb morphogenesis 3/1115 34/18722 0.33017754885702 0.592344735667887 BMPR1A/GPC3/CTNNB1 3 GO:0035308 negative regulation of protein dephosphorylation 3/1115 34/18722 0.33017754885702 0.592344735667887 BOD1L1/YWHAE/ROCK1 3 GO:0035890 exit from host 3/1115 34/18722 0.33017754885702 0.592344735667887 PPIA/DDB1/TRIM13 3 GO:0035891 exit from host cell 3/1115 34/18722 0.33017754885702 0.592344735667887 PPIA/DDB1/TRIM13 3 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 3/1115 34/18722 0.33017754885702 0.592344735667887 PUM2/PUM1/ANKRD17 3 GO:0070050 neuron cellular homeostasis 3/1115 34/18722 0.33017754885702 0.592344735667887 ATP2B1/TAOK1/CLCN3 3 GO:0070884 regulation of calcineurin-NFAT signaling cascade 3/1115 34/18722 0.33017754885702 0.592344735667887 ATP2B4/NFAT5/SLC9A1 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/1115 34/18722 0.33017754885702 0.592344735667887 GJA1/GJA5/PKP2 3 GO:1904893 negative regulation of receptor signaling pathway via STAT 3/1115 34/18722 0.33017754885702 0.592344735667887 PARP14/CAV1/SUZ12 3 GO:2000780 negative regulation of double-strand break repair 3/1115 34/18722 0.33017754885702 0.592344735667887 UBR5/RIF1/TRIP12 3 GO:1903038 negative regulation of leukocyte cell-cell adhesion 10/1115 141/18722 0.330937562720951 0.593508783126355 ANXA1/CD74/DLG5/DLG1/WNK1/GLI3/MIA3/HMGB1/RC3H1/ERBB2 10 GO:0019693 ribose phosphate metabolic process 26/1115 396/18722 0.331372683550455 0.59365166298015 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RAN/ACSL3/INSR/PDE10A/PDE7A/TKT/ELOVL1/FASN/GPAT4/RHOA 26 GO:0002698 negative regulation of immune effector process 8/1115 110/18722 0.33240132555431 0.59365166298015 CD46/GRN/ANXA1/PRKDC/CD47/APPL1/RC3H1/SERPINB9 8 GO:0006749 glutathione metabolic process 5/1115 64/18722 0.333111446657946 0.59365166298015 ARL6IP5/GSTP1/CLIC3/IDH1/SOD1 5 GO:0006940 regulation of smooth muscle contraction 5/1115 64/18722 0.333111446657946 0.59365166298015 ATP2B1/CAV1/ZDHHC21/RHOA/SOD1 5 GO:0017156 calcium-ion regulated exocytosis 5/1115 64/18722 0.333111446657946 0.59365166298015 SCIN/ATP2A2/SYT7/RAB3GAP1/REST 5 GO:0046530 photoreceptor cell differentiation 5/1115 64/18722 0.333111446657946 0.59365166298015 TUG1/PRKCI/MYO7A/NAGLU/AHI1 5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 5/1115 64/18722 0.333111446657946 0.59365166298015 LRP1/LRP5/DYNLL1/KIF5B/EFNA5 5 GO:0015850 organic hydroxy compound transport 19/1115 284/18722 0.333313511931425 0.59365166298015 LRP1/ABCA1/SLC6A4/SLC5A3/FURIN/SYT7/SLC16A1/NPC1/NISCH/C1QTNF1/LY6E/OSBPL8/ABCD3/TSKU/CAV1/SREBF2/LPCAT3/ACTB/ANXA2 19 GO:0022409 positive regulation of cell-cell adhesion 19/1115 284/18722 0.333313511931425 0.59365166298015 CD46/IL6ST/ANXA1/DPP4/PLPP3/CD74/GCNT2/NFAT5/ANK3/RPS3/DOCK8/BMP7/CD47/TFRC/GLI3/F11R/HMGB1/CAV1/RHOA 19 GO:1902107 positive regulation of leukocyte differentiation 11/1115 157/18722 0.333358478864494 0.59365166298015 CD46/ANXA1/ZFP36L1/CD74/PRKDC/ATP6AP1/KLF10/TMEM64/GLI3/HMGB1/RHOA 11 GO:1903708 positive regulation of hemopoiesis 11/1115 157/18722 0.333358478864494 0.59365166298015 CD46/ANXA1/ZFP36L1/CD74/PRKDC/ATP6AP1/KLF10/TMEM64/GLI3/HMGB1/RHOA 11 GO:2000377 regulation of reactive oxygen species metabolic process 11/1115 157/18722 0.333358478864494 0.59365166298015 EGFR/SLC5A3/BMP7/GSTP1/VDAC1/CLCN3/MAPK14/CFLAR/ARF4/RHOA/SOD1 11 GO:0002762 negative regulation of myeloid leukocyte differentiation 4/1115 49/18722 0.333768084615915 0.59365166298015 FBN1/CDK6/TLR3/CTNNB1 4 GO:0006376 mRNA splice site selection 4/1115 49/18722 0.333768084615915 0.59365166298015 LUC7L3/SF1/CELF1/SRSF9 4 GO:0009409 response to cold 4/1115 49/18722 0.333768084615915 0.59365166298015 ATP2B1/ADRB1/SLC9A1/DNAJC3 4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 4/1115 49/18722 0.333768084615915 0.59365166298015 BMP7/TGFBR1/BMPR2/BMPR1A 4 GO:0043457 regulation of cellular respiration 4/1115 49/18722 0.333768084615915 0.59365166298015 IL10RB/TRPV4/OPN3/RHOA 4 GO:1901799 negative regulation of proteasomal protein catabolic process 4/1115 49/18722 0.333768084615915 0.59365166298015 HSP90AB1/USP25/SMARCC1/EIF3H 4 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 4/1115 49/18722 0.333768084615915 0.59365166298015 GJA1/ADAMTS1/BMPR1A/HPGD 4 GO:1904894 positive regulation of receptor signaling pathway via STAT 4/1115 49/18722 0.333768084615915 0.59365166298015 CSH1/PRLR/IL10RB/OCIAD2 4 GO:0002834 regulation of response to tumor cell 2/1115 20/18722 0.336243234473117 0.59365166298015 HMGB1/MR1 2 GO:0002837 regulation of immune response to tumor cell 2/1115 20/18722 0.336243234473117 0.59365166298015 HMGB1/MR1 2 GO:0006525 arginine metabolic process 2/1115 20/18722 0.336243234473117 0.59365166298015 ATP2B4/CLN3 2 GO:0006607 NLS-bearing protein import into nucleus 2/1115 20/18722 0.336243234473117 0.59365166298015 RANBP2/KPNB1 2 GO:0007194 negative regulation of adenylate cyclase activity 2/1115 20/18722 0.336243234473117 0.59365166298015 AKAP9/EDNRB 2 GO:0007620 copulation 2/1115 20/18722 0.336243234473117 0.59365166298015 SLC6A4/EDNRB 2 GO:0010042 response to manganese ion 2/1115 20/18722 0.336243234473117 0.59365166298015 APP/HSPA5 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/1115 20/18722 0.336243234473117 0.59365166298015 CALM1/PKD2 2 GO:0014047 glutamate secretion 2/1115 20/18722 0.336243234473117 0.59365166298015 GJA1/RAB3GAP1 2 GO:0031498 chromatin disassembly 2/1115 20/18722 0.336243234473117 0.59365166298015 ARID1A/SMARCC1 2 GO:0032495 response to muramyl dipeptide 2/1115 20/18722 0.336243234473117 0.59365166298015 JAG1/MAPK14 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/1115 20/18722 0.336243234473117 0.59365166298015 MPHOSPH8/TOP2B 2 GO:0042359 vitamin D metabolic process 2/1115 20/18722 0.336243234473117 0.59365166298015 LRP2/LGMN 2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 2/1115 20/18722 0.336243234473117 0.59365166298015 ITM2B/AGO2 2 GO:0043651 linoleic acid metabolic process 2/1115 20/18722 0.336243234473117 0.59365166298015 GSTP1/ELOVL1 2 GO:0045063 T-helper 1 cell differentiation 2/1115 20/18722 0.336243234473117 0.59365166298015 ANXA1/HMGB1 2 GO:0046485 ether lipid metabolic process 2/1115 20/18722 0.336243234473117 0.59365166298015 NCEH1/FASN 2 GO:0060044 negative regulation of cardiac muscle cell proliferation 2/1115 20/18722 0.336243234473117 0.59365166298015 GJA1/JARID2 2 GO:0061318 renal filtration cell differentiation 2/1115 20/18722 0.336243234473117 0.59365166298015 IQGAP1/JAG1 2 GO:0070166 enamel mineralization 2/1115 20/18722 0.336243234473117 0.59365166298015 SLC4A2/ITGB6 2 GO:0071397 cellular response to cholesterol 2/1115 20/18722 0.336243234473117 0.59365166298015 DAG1/ABCA1 2 GO:0072112 glomerular visceral epithelial cell differentiation 2/1115 20/18722 0.336243234473117 0.59365166298015 IQGAP1/JAG1 2 GO:0097320 plasma membrane tubulation 2/1115 20/18722 0.336243234473117 0.59365166298015 WASL/ASAP1 2 GO:1901679 nucleotide transmembrane transport 2/1115 20/18722 0.336243234473117 0.59365166298015 SLC19A1/SLC25A36 2 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/1115 20/18722 0.336243234473117 0.59365166298015 PPIA/HSPB1 2 GO:1903817 negative regulation of voltage-gated potassium channel activity 2/1115 20/18722 0.336243234473117 0.59365166298015 ANK3/CAV1 2 GO:2000010 positive regulation of protein localization to cell surface 2/1115 20/18722 0.336243234473117 0.59365166298015 HSP90AB1/GPD1L 2 GO:0008585 female gonad development 7/1115 95/18722 0.336995511094468 0.594783151647393 ADAMTS1/HSPA5/NR2F2/ZFX/ARID5B/IDH1/SOD1 7 GO:0021766 hippocampus development 6/1115 80/18722 0.341333081695583 0.60223969701676 CDK6/ATP2B4/KIF5B/GLI3/TSKU/UBA6 6 GO:0023061 signal release 30/1115 463/18722 0.342198107072064 0.603566466355385 EGFR/LRP1/ANXA1/LRP5/WLS/ABCA1/SLC6A4/DPP4/DYNLL1/GJA1/FAM3B/CALM1/P2RX4/ATP2A2/SYT7/CCDC186/SLC16A1/TCF7L2/KIF5B/PPP1R9A/TRPV4/RAB3GAP1/NISCH/SMAD2/C1QTNF1/EFNA5/PPP3CA/REST/ISL1/MCTP2 30 GO:0045619 regulation of lymphocyte differentiation 12/1115 174/18722 0.342371462696973 0.603672800310151 CD46/ANXA1/ZFP36L1/CD74/PRKDC/GLI3/HMGB1/CLPTM1/RC3H1/ERBB2/RHOA/SOD1 12 GO:0062012 regulation of small molecule metabolic process 22/1115 334/18722 0.343306976869982 0.605122465998295 ANXA1/APP/ATP2B4/CD74/RANBP2/NCOR1/ENO1/DDB1/SLC35B4/EPM2AIP1/SORBS1/TMSB4X/C1QTNF1/CLN3/HMGB1/SOGA1/NCOA2/CAV1/LPCAT3/INSR/REST/SOD1 22 GO:0051224 negative regulation of protein transport 9/1115 127/18722 0.344617393859911 0.606375273117279 ANXA1/LMAN1/ERLEC1/FERMT1/FRMD4A/LYPLA1/PPP3CA/REST/RHBDF1 9 GO:0002720 positive regulation of cytokine production involved in immune response 5/1115 65/18722 0.345087900849034 0.606375273117279 CD74/FZD5/DHX36/SEMA7A/MAVS 5 GO:0045682 regulation of epidermis development 5/1115 65/18722 0.345087900849034 0.606375273117279 ZFP36L1/NCOA3/SGPP1/ROCK1/ESRP1 5 GO:0006644 phospholipid metabolic process 25/1115 383/18722 0.346380491099039 0.606375273117279 PLPP3/PGAP1/SERINC1/HEXB/SLC44A2/CDS1/SGPP1/SMG1/SERINC3/GPAA1/SMPD1/SLC44A1/PLBD1/CLN3/OSBPL8/ACSL3/PISD/LPCAT3/AGPAT1/ISYNA1/IDH1/ATM/SERINC2/GPAT4/ETNK1 25 GO:0000731 DNA synthesis involved in DNA repair 3/1115 35/18722 0.346803648215347 0.606375273117279 REV3L/USP10/USP43 3 GO:0001569 branching involved in blood vessel morphogenesis 3/1115 35/18722 0.346803648215347 0.606375273117279 NRP1/COL4A1/CTNNB1 3 GO:0002209 behavioral defense response 3/1115 35/18722 0.346803648215347 0.606375273117279 DPP4/GJA1/VDAC1 3 GO:0006471 protein ADP-ribosylation 3/1115 35/18722 0.346803648215347 0.606375273117279 TNKS2/PARP14/ARF4 3 GO:0010837 regulation of keratinocyte proliferation 3/1115 35/18722 0.346803648215347 0.606375273117279 ZFP36L1/PTPRK/FGFR2 3 GO:0018149 peptide cross-linking 3/1115 35/18722 0.346803648215347 0.606375273117279 ANXA1/FN1/DSP 3 GO:0031076 embryonic camera-type eye development 3/1115 35/18722 0.346803648215347 0.606375273117279 BMP7/FZD5/PHACTR4 3 GO:0032350 regulation of hormone metabolic process 3/1115 35/18722 0.346803648215347 0.606375273117279 TCF7L2/ATP1A1/REST 3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 3/1115 35/18722 0.346803648215347 0.606375273117279 HSP90AB1/SMARCC1/EIF3H 3 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 3/1115 35/18722 0.346803648215347 0.606375273117279 UFL1/SKP2/ISL1 3 GO:0045454 cell redox homeostasis 3/1115 35/18722 0.346803648215347 0.606375273117279 PRDX1/PRDX4/PRDX3 3 GO:0048821 erythrocyte development 3/1115 35/18722 0.346803648215347 0.606375273117279 RPS6/SLC11A2/PTBP3 3 GO:0071108 protein K48-linked deubiquitination 3/1115 35/18722 0.346803648215347 0.606375273117279 USP25/USP9X/USP34 3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 3/1115 35/18722 0.346803648215347 0.606375273117279 ANXA1/NRP1/AKT3 3 GO:0097502 mannosylation 3/1115 35/18722 0.346803648215347 0.606375273117279 TMTC3/ALG2/DPY19L1 3 GO:0098801 regulation of renal system process 3/1115 35/18722 0.346803648215347 0.606375273117279 GJA1/GJA5/EDNRB 3 GO:0098810 neurotransmitter reuptake 3/1115 35/18722 0.346803648215347 0.606375273117279 ITGB1/SLC6A4/SLC29A1 3 GO:0106056 regulation of calcineurin-mediated signaling 3/1115 35/18722 0.346803648215347 0.606375273117279 ATP2B4/NFAT5/SLC9A1 3 GO:1905508 protein localization to microtubule organizing center 3/1115 35/18722 0.346803648215347 0.606375273117279 GOLGB1/CEP350/PCM1 3 GO:0034763 negative regulation of transmembrane transport 10/1115 143/18722 0.346881698800752 0.606375273117279 OAZ1/SLC43A2/CALM1/ANK3/ARL6IP5/YWHAE/C4orf3/VDAC1/CAV1/PKD2 10 GO:0062013 positive regulation of small molecule metabolic process 10/1115 143/18722 0.346881698800752 0.606375273117279 ANXA1/APP/CD74/ENO1/DDB1/EPM2AIP1/SORBS1/TMSB4X/HMGB1/INSR 10 GO:0000387 spliceosomal snRNP assembly 4/1115 50/18722 0.347538553238223 0.606375273117279 SNRPD2/SNRPF/SNRPD1/SNRPB 4 GO:0008089 anterograde axonal transport 4/1115 50/18722 0.347538553238223 0.606375273117279 KIF5B/HSPB1/TRAK2/SOD1 4 GO:0038202 TORC1 signaling 4/1115 50/18722 0.347538553238223 0.606375273117279 SMG1/C9orf72/ITFG2/ATM 4 GO:0045814 negative regulation of gene expression, epigenetic 4/1115 50/18722 0.347538553238223 0.606375273117279 TPR/DNMT3A/MPHOSPH8/ATF7IP 4 GO:0050873 brown fat cell differentiation 4/1115 50/18722 0.347538553238223 0.606375273117279 ADRB1/BMP7/TRPV4/MAPK14 4 GO:1904036 negative regulation of epithelial cell apoptotic process 4/1115 50/18722 0.347538553238223 0.606375273117279 TCF7L2/CFLAR/CAST/WFS1 4 GO:0001676 long-chain fatty acid metabolic process 8/1115 112/18722 0.350532281056345 0.611398839777794 SLC27A2/PTGES3/GSTP1/SLC27A6/CPT2/ABCD3/ACSL3/ELOVL1 8 GO:0000422 autophagy of mitochondrion 6/1115 81/18722 0.352080989921616 0.61349882675963 VPS13C/RB1CC1/FZD5/VDAC1/ATG9A/SREBF2 6 GO:0008589 regulation of smoothened signaling pathway 6/1115 81/18722 0.352080989921616 0.61349882675963 DLG5/HERC4/GLI3/FGFR2/CREBBP/GPC3 6 GO:0061726 mitochondrion disassembly 6/1115 81/18722 0.352080989921616 0.61349882675963 VPS13C/RB1CC1/FZD5/VDAC1/ATG9A/SREBF2 6 GO:0033865 nucleoside bisphosphate metabolic process 9/1115 128/18722 0.353119164304007 0.614705972683109 SLC26A2/ACSS1/TPST2/CROT/TECR/ACSL3/ELOVL1/FASN/GPAT4 9 GO:0033875 ribonucleoside bisphosphate metabolic process 9/1115 128/18722 0.353119164304007 0.614705972683109 SLC26A2/ACSS1/TPST2/CROT/TECR/ACSL3/ELOVL1/FASN/GPAT4 9 GO:0034032 purine nucleoside bisphosphate metabolic process 9/1115 128/18722 0.353119164304007 0.614705972683109 SLC26A2/ACSS1/TPST2/CROT/TECR/ACSL3/ELOVL1/FASN/GPAT4 9 GO:0046651 lymphocyte proliferation 19/1115 288/18722 0.355803036639415 0.61716622416083 CD46/IL6ST/ANXA1/RPS6/SLC39A10/MIF/CD74/RPS3/DOCK8/DLG5/DLG1/TFRC/NCSTN/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 19 GO:0009259 ribonucleotide metabolic process 25/1115 385/18722 0.356148982715509 0.61716622416083 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RAN/ACSL3/INSR/PDE10A/PDE7A/ELOVL1/FASN/GPAT4/RHOA 25 GO:0030193 regulation of blood coagulation 5/1115 66/18722 0.357090432057307 0.61716622416083 TFPI/ANO6/C1QTNF1/CAV1/ANXA2 5 GO:0050766 positive regulation of phagocytosis 5/1115 66/18722 0.357090432057307 0.61716622416083 LRP1/ANO6/CD47/RAB31/SOD1 5 GO:0050918 positive chemotaxis 5/1115 66/18722 0.357090432057307 0.61716622416083 LRP1/MET/NRP1/MIF/HMGB1 5 GO:1905953 negative regulation of lipid localization 5/1115 66/18722 0.357090432057307 0.61716622416083 ITGAV/ABCA1/OSBPL8/SREBF2/PLA2R1 5 GO:0000002 mitochondrial genome maintenance 2/1115 21/18722 0.35834712397426 0.61716622416083 SLC25A36/AKT3 2 GO:0002689 negative regulation of leukocyte chemotaxis 2/1115 21/18722 0.35834712397426 0.61716622416083 MIF/DPP4 2 GO:0003091 renal water homeostasis 2/1115 21/18722 0.35834712397426 0.61716622416083 ATP6V1B1/WFS1 2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 2/1115 21/18722 0.35834712397426 0.61716622416083 COX6A1/CYCS 2 GO:0006450 regulation of translational fidelity 2/1115 21/18722 0.35834712397426 0.61716622416083 IARS2/RPS9 2 GO:0007063 regulation of sister chromatid cohesion 2/1115 21/18722 0.35834712397426 0.61716622416083 ATRX/CTNNB1 2 GO:0007252 I-kappaB phosphorylation 2/1115 21/18722 0.35834712397426 0.61716622416083 PRDX4/TLR3 2 GO:0007617 mating behavior 2/1115 21/18722 0.35834712397426 0.61716622416083 APP/HEXB 2 GO:0010878 cholesterol storage 2/1115 21/18722 0.35834712397426 0.61716622416083 ABCA1/SREBF2 2 GO:0022010 central nervous system myelination 2/1115 21/18722 0.35834712397426 0.61716622416083 B4GALT5/NCSTN 2 GO:0031145 anaphase-promoting complex-dependent catabolic process 2/1115 21/18722 0.35834712397426 0.61716622416083 UBE2C/CDC20 2 GO:0032291 axon ensheathment in central nervous system 2/1115 21/18722 0.35834712397426 0.61716622416083 B4GALT5/NCSTN 2 GO:0032303 regulation of icosanoid secretion 2/1115 21/18722 0.35834712397426 0.61716622416083 P2RX4/PLA2R1 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/1115 21/18722 0.35834712397426 0.61716622416083 SLC26A2/TPST2 2 GO:0034312 diol biosynthetic process 2/1115 21/18722 0.35834712397426 0.61716622416083 ASAH1/SPTLC3 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/1115 21/18722 0.35834712397426 0.61716622416083 TPR/FERMT1 2 GO:0046885 regulation of hormone biosynthetic process 2/1115 21/18722 0.35834712397426 0.61716622416083 ATP1A1/REST 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/1115 21/18722 0.35834712397426 0.61716622416083 SLC26A2/TPST2 2 GO:0060117 auditory receptor cell development 2/1115 21/18722 0.35834712397426 0.61716622416083 MYO7A/SOD1 2 GO:0072170 metanephric tubule development 2/1115 21/18722 0.35834712397426 0.61716622416083 LGR4/PKD2 2 GO:0072243 metanephric nephron epithelium development 2/1115 21/18722 0.35834712397426 0.61716622416083 LGR4/PKD2 2 GO:0072311 glomerular epithelial cell differentiation 2/1115 21/18722 0.35834712397426 0.61716622416083 IQGAP1/JAG1 2 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 2/1115 21/18722 0.35834712397426 0.61716622416083 LGR4/MAGED1 2 GO:0097062 dendritic spine maintenance 2/1115 21/18722 0.35834712397426 0.61716622416083 IGF1R/INSR 2 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/1115 21/18722 0.35834712397426 0.61716622416083 SLC35F6/HSPA1A 2 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 2/1115 21/18722 0.35834712397426 0.61716622416083 CFLAR/RHOA 2 GO:2001014 regulation of skeletal muscle cell differentiation 2/1115 21/18722 0.35834712397426 0.61716622416083 DDX17/GPC1 2 GO:0044106 cellular amine metabolic process 8/1115 113/18722 0.359644273830036 0.619200508861195 ATP2B4/OAZ1/SMS/AOC1/SLC44A1/CLN3/LY6E/SAT1 8 GO:0010874 regulation of cholesterol efflux 4/1115 51/18722 0.361316334024813 0.621277908972134 LRP1/ABCA1/CAV1/SREBF2 4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4/1115 51/18722 0.361316334024813 0.621277908972134 ASH1L/GSTP1/USP10/RHOA 4 GO:0045668 negative regulation of osteoblast differentiation 4/1115 51/18722 0.361316334024813 0.621277908972134 CRIM1/LRP5/CDK6/TMEM64 4 GO:0048013 ephrin receptor signaling pathway 4/1115 51/18722 0.361316334024813 0.621277908972134 RASA1/EPHB4/RBPJ/EFNA5 4 GO:0007093 mitotic cell cycle checkpoint signaling 9/1115 129/18722 0.361648307699445 0.62144844377449 PRKDC/TPR/RPL26/TAOK1/TAOK3/CCND1/ZNF207/FOXO4/ATM 9 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/1115 129/18722 0.361648307699445 0.62144844377449 CTSD/RPS3/ARL6IP5/HMGB1/CFLAR/REST/CYCS/HSPE1/RHOA 9 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 18/1115 273/18722 0.362194864485603 0.622187381431349 TENM3/CDH1/ITGB1/DSC3/PTPRF/DSC2/DSG2/PLXNB2/PALLD/PCDH11X/CLSTN1/FAT1/WNK1/PTPRM/CLDN4/MAPK14/OBSL1/CADM1 18 GO:0009205 purine ribonucleoside triphosphate metabolic process 6/1115 82/18722 0.362854510153282 0.622719456672572 ALDOA/ENO1/TMSB4X/AK3/RAN/RHOA 6 GO:0043242 negative regulation of protein-containing complex disassembly 6/1115 82/18722 0.362854510153282 0.622719456672572 SCIN/SPTBN1/ADD3/TAOK1/SPTAN1/CAMSAP2 6 GO:0046364 monosaccharide biosynthetic process 6/1115 82/18722 0.362854510153282 0.622719456672572 RANBP2/DDB1/TPI1/SLC35B4/SOGA1/G6PC3 6 GO:0014741 negative regulation of muscle hypertrophy 3/1115 36/18722 0.363388065786127 0.623037402931064 ATP2B4/P2RX4/JARID2 3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/1115 36/18722 0.363388065786127 0.623037402931064 LRP1/DYNLL1/KIF5B 3 GO:0006813 potassium ion transport 16/1115 241/18722 0.363389861908097 0.623037402931064 AKAP9/ITGB1/ANO6/ANK3/YWHAE/SLC9A1/DLG1/KCNN4/KIF5B/SLC1A3/GJA5/ATP1A1/WNK1/CAV1/ALG10B/PKD2 16 GO:0051302 regulation of cell division 12/1115 177/18722 0.364127262244092 0.624101269059778 CALM1/NCOA3/YBX1/BIRC6/PKN2/RAB11FIP4/SETD2/PDGFD/GAREM1/FGFR2/CAT/RHOA 12 GO:0046660 female sex differentiation 8/1115 114/18722 0.368780158079766 0.631622723941727 LRP2/ADAMTS1/HSPA5/NR2F2/ZFX/ARID5B/IDH1/SOD1 8 GO:1903008 organelle disassembly 8/1115 114/18722 0.368780158079766 0.631622723941727 VPS13C/RB1CC1/UFL1/FZD5/KIF5B/VDAC1/ATG9A/SREBF2 8 GO:0045165 cell fate commitment 17/1115 258/18722 0.368879041624891 0.631622723941727 ITGB1/NRP1/PRKDC/JAG1/TGFBR1/TCF7L2/NR2F2/RBPJ/GLI3/SMAD2/ESRP1/BMPR1A/FGFR2/ISL1/MGA/CTNNB1/RHOA 17 GO:0050435 amyloid-beta metabolic process 5/1115 67/18722 0.369107117193892 0.631622723941727 MME/RTN4/ADAM10/ROCK1/NCSTN 5 GO:0061180 mammary gland epithelium development 5/1115 67/18722 0.369107117193892 0.631622723941727 LRP5/RTN4/DDR1/CCND1/FGFR2 5 GO:0006282 regulation of DNA repair 9/1115 130/18722 0.370200463354634 0.633290699727777 EGFR/PRKDC/RPS3/UBR5/RIF1/TRIP12/SETD2/HMGB1/FUS 9 GO:0042542 response to hydrogen peroxide 10/1115 146/18722 0.371010077139697 0.634269228898125 MET/ANXA1/LDHA/RPS3/NET1/PDGFD/PPP1R15B/CAT/PRDX3/SOD1 10 GO:0045580 regulation of T cell differentiation 10/1115 146/18722 0.371010077139697 0.634269228898125 CD46/ANXA1/CD74/GLI3/HMGB1/CLPTM1/RC3H1/ERBB2/RHOA/SOD1 10 GO:0051100 negative regulation of binding 11/1115 162/18722 0.37137995139853 0.634698322828666 PTPRF/ATP2A2/C4orf3/ARHGAP28/ROCK1/RSF1/C9orf72/TMSB4X/CAV1/ACTB/PPP3CA 11 GO:0032943 mononuclear cell proliferation 19/1115 291/18722 0.372867358996857 0.637036425498951 CD46/IL6ST/ANXA1/RPS6/SLC39A10/MIF/CD74/RPS3/DOCK8/DLG5/DLG1/TFRC/NCSTN/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 19 GO:0051899 membrane depolarization 6/1115 83/18722 0.373645009443224 0.637956733424168 ANK3/P2RX4/IFI6/GJA5/GPD1L/CAV1 6 GO:0061053 somite development 6/1115 83/18722 0.373645009443224 0.637956733424168 PRKDC/RBPJ/MIB1/COBL/RBBP6/BMPR1A 6 GO:0002218 activation of innate immune response 4/1115 52/18722 0.375084152836113 0.640004567590926 PRKDC/HMGB1/MAVS/CREBBP 4 GO:1903426 regulation of reactive oxygen species biosynthetic process 4/1115 52/18722 0.375084152836113 0.640004567590926 SLC5A3/CLCN3/CFLAR/RHOA 4 GO:0042100 B cell proliferation 7/1115 99/18722 0.376354397343713 0.641966813871593 SLC39A10/MIF/CD74/TFRC/VAV3/RC3H1/ATM 7 GO:0046474 glycerophospholipid biosynthetic process 14/1115 211/18722 0.377556489766557 0.64273395442555 PGAP1/SLC44A2/CDS1/SMG1/GPAA1/SLC44A1/CLN3/ACSL3/PISD/LPCAT3/AGPAT1/ATM/GPAT4/ETNK1 14 GO:0007416 synapse assembly 12/1115 179/18722 0.378739209696651 0.64273395442555 CDH1/APP/PLXNB1/NRCAM/PLXNB2/DLG5/RYK/FZD5/CLSTN1/PPP1R9A/TPBG/OBSL1 12 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3/1115 37/18722 0.379903047052379 0.64273395442555 RPS8/RPS16/RPS21 3 GO:0001990 regulation of systemic arterial blood pressure by hormone 3/1115 37/18722 0.379903047052379 0.64273395442555 MME/ENPEP/RHOA 3 GO:0032570 response to progesterone 3/1115 37/18722 0.379903047052379 0.64273395442555 CLDN4/NCOA2/CAV1 3 GO:0042401 cellular biogenic amine biosynthetic process 3/1115 37/18722 0.379903047052379 0.64273395442555 OAZ1/SMS/SAT1 3 GO:0048009 insulin-like growth factor receptor signaling pathway 3/1115 37/18722 0.379903047052379 0.64273395442555 CRIM1/IGF1R/PHIP 3 GO:0060428 lung epithelium development 3/1115 37/18722 0.379903047052379 0.64273395442555 RBPJ/NFIB/FGFR2 3 GO:0002089 lens morphogenesis in camera-type eye 2/1115 22/18722 0.38017490692562 0.64273395442555 ABI2/CTNNB1 2 GO:0006379 mRNA cleavage 2/1115 22/18722 0.38017490692562 0.64273395442555 AGO2/MOV10 2 GO:0006662 glycerol ether metabolic process 2/1115 22/18722 0.38017490692562 0.64273395442555 NCEH1/FASN 2 GO:0008211 glucocorticoid metabolic process 2/1115 22/18722 0.38017490692562 0.64273395442555 ATP1A1/REST 2 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/1115 22/18722 0.38017490692562 0.64273395442555 CALM1/DMD 2 GO:0014821 phasic smooth muscle contraction 2/1115 22/18722 0.38017490692562 0.64273395442555 DLG1/EDNRB 2 GO:0016137 glycoside metabolic process 2/1115 22/18722 0.38017490692562 0.64273395442555 GUSB/FUCA1 2 GO:0031281 positive regulation of cyclase activity 2/1115 22/18722 0.38017490692562 0.64273395442555 NF1/MAPK14 2 GO:0034755 iron ion transmembrane transport 2/1115 22/18722 0.38017490692562 0.64273395442555 SLC40A1/SLC11A2 2 GO:0035268 protein mannosylation 2/1115 22/18722 0.38017490692562 0.64273395442555 TMTC3/DPY19L1 2 GO:0045061 thymic T cell selection 2/1115 22/18722 0.38017490692562 0.64273395442555 CD74/GLI3 2 GO:0045540 regulation of cholesterol biosynthetic process 2/1115 22/18722 0.38017490692562 0.64273395442555 LPCAT3/SOD1 2 GO:0046628 positive regulation of insulin receptor signaling pathway 2/1115 22/18722 0.38017490692562 0.64273395442555 SORBS1/OSBPL8 2 GO:0048026 positive regulation of mRNA splicing, via spliceosome 2/1115 22/18722 0.38017490692562 0.64273395442555 TRA2B/NCL 2 GO:0051220 cytoplasmic sequestering of protein 2/1115 22/18722 0.38017490692562 0.64273395442555 TMSB4X/PKD2 2 GO:0055093 response to hyperoxia 2/1115 22/18722 0.38017490692562 0.64273395442555 CAV1/CAT 2 GO:0060444 branching involved in mammary gland duct morphogenesis 2/1115 22/18722 0.38017490692562 0.64273395442555 LRP5/DDR1 2 GO:0106118 regulation of sterol biosynthetic process 2/1115 22/18722 0.38017490692562 0.64273395442555 LPCAT3/SOD1 2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 2/1115 22/18722 0.38017490692562 0.64273395442555 RBPJ/CHD6 2 GO:2000193 positive regulation of fatty acid transport 2/1115 22/18722 0.38017490692562 0.64273395442555 P2RX4/PLA2R1 2 GO:0007585 respiratory gaseous exchange by respiratory system 5/1115 68/18722 0.381126358495497 0.643120615678717 GAA/SLC5A3/MAN2A1/MAN1A2/CHST11 5 GO:0046637 regulation of alpha-beta T cell differentiation 5/1115 68/18722 0.381126358495497 0.643120615678717 ANXA1/GLI3/HMGB1/RC3H1/RHOA 5 GO:0051926 negative regulation of calcium ion transport 5/1115 68/18722 0.381126358495497 0.643120615678717 CALM1/YWHAE/C4orf3/VDAC1/PKD2 5 GO:0061912 selective autophagy 5/1115 68/18722 0.381126358495497 0.643120615678717 VPS13C/RB1CC1/UFL1/VDAC1/WDFY3 5 GO:1900046 regulation of hemostasis 5/1115 68/18722 0.381126358495497 0.643120615678717 TFPI/ANO6/C1QTNF1/CAV1/ANXA2 5 GO:1901607 alpha-amino acid biosynthetic process 5/1115 68/18722 0.381126358495497 0.643120615678717 ATP2B4/SERINC3/MTR/CLN3/ALDH18A1 5 GO:0042440 pigment metabolic process 6/1115 84/18722 0.384444029255469 0.648513956459699 SLC11A2/IREB2/NFE2L1/OPN3/APPL1/RAPGEF2 6 GO:0046545 development of primary female sexual characteristics 7/1115 100/18722 0.386239684157651 0.651131567324818 ADAMTS1/HSPA5/NR2F2/ZFX/ARID5B/IDH1/SOD1 7 GO:0060079 excitatory postsynaptic potential 7/1115 100/18722 0.386239684157651 0.651131567324818 APP/P2RX4/PPP1R9A/SLC29A1/RAB3GAP1/S1PR2/PPP3CA 7 GO:0050806 positive regulation of synaptic transmission 11/1115 164/18722 0.386738569531723 0.651766800104126 EGFR/MME/LGMN/APP/CLSTN1/KIF5B/SLC1A3/PPP1R9A/NCSTN/RAB3GAP1/PAIP2 11 GO:0018107 peptidyl-threonine phosphorylation 8/1115 116/18722 0.38710257788538 0.652174396759245 APP/CALM1/PRKDC/BMP7/ROCK1/TGFBR1/WNK1/S1PR2 8 GO:0034381 plasma lipoprotein particle clearance 4/1115 53/18722 0.388825454265228 0.65466386008264 LIPA/VLDLR/NCEH1/ANXA2 4 GO:0050819 negative regulation of coagulation 4/1115 53/18722 0.388825454265228 0.65466386008264 ANXA5/TFPI/C1QTNF1/ANXA2 4 GO:0010948 negative regulation of cell cycle process 19/1115 294/18722 0.39006250236276 0.656539628031139 NPM1/ZFP36L1/ATRX/PRKDC/BMP7/TPR/USP47/RPL26/TAOK1/DLG1/TAOK3/JADE1/MAPK14/CCND1/ZNF207/FEM1B/PKD2/FOXO4/ATM 19 GO:0018205 peptidyl-lysine modification 24/1115 376/18722 0.392506971215514 0.660445861745865 ASH1L/ATRX/BRD4/NCOA3/MORF4L2/KMT2C/RPS6KA5/RANBP2/TET2/RIF1/ZNF451/NSD1/JARID2/SENP6/PIAS1/JADE1/SETD2/PLOD1/KMT2A/SUZ12/ISL1/CREBBP/CTNNB1/MORF4L1 24 GO:0009636 response to toxic substance 17/1115 262/18722 0.393188293772674 0.66134435225756 CDH1/PRDX1/SLC6A4/BMP7/PRDX4/DNMT3A/GPX3/GSTP1/SLC22A5/PPP1R9A/SLC22A18/GPX8/CAT/ATP7B/PRDX3/SOD1/SRSF9 17 GO:0032640 tumor necrosis factor production 12/1115 181/18722 0.393412560923396 0.66134435225756 APP/DICER1/MIF/GSTP1/CD47/FZD5/HSPB1/FOXP1/HMGB1/TLR3/ISL1/MAVS 12 GO:0032680 regulation of tumor necrosis factor production 12/1115 181/18722 0.393412560923396 0.66134435225756 APP/DICER1/MIF/GSTP1/CD47/FZD5/HSPB1/FOXP1/HMGB1/TLR3/ISL1/MAVS 12 GO:0006325 chromatin organization 26/1115 409/18722 0.393947186720822 0.662034633271159 NPM1/ATRX/BRD4/SMARCA2/NR3C1/BPTF/TPR/DNMT3A/NCOR1/ARID1A/RSF1/PBRM1/KDM5A/MPHOSPH8/BAZ2B/SMARCC1/JARID2/SETD2/CHD6/HMGB1/ACTB/HNRNPC/ATF7IP/SHPRH/TDG/RERE 26 GO:0031668 cellular response to extracellular stimulus 16/1115 246/18722 0.394746060347401 0.663168412899551 ATP2B1/HNRNPA1/SLC2A1/SLC38A2/PLEC/FOLR1/GSTP1/LAMP2/HSPA5/AOC1/KLF10/SKP2/CPEB4/BMPR2/SREBF2/ITFG2 16 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 6/1115 85/18722 0.395243298433494 0.663520544405362 IL6ST/CSH1/PARP14/CAV1/SUZ12/ISL1 6 GO:2000779 regulation of double-strand break repair 6/1115 85/18722 0.395243298433494 0.663520544405362 PRKDC/UBR5/RIF1/TRIP12/SETD2/FUS 6 GO:0007094 mitotic spindle assembly checkpoint signaling 3/1115 38/18722 0.396322722627589 0.663520544405362 TPR/ZNF207/ATM 3 GO:0009309 amine biosynthetic process 3/1115 38/18722 0.396322722627589 0.663520544405362 OAZ1/SMS/SAT1 3 GO:0035136 forelimb morphogenesis 3/1115 38/18722 0.396322722627589 0.663520544405362 NIPBL/ATRX/CTNNB1 3 GO:0035337 fatty-acyl-CoA metabolic process 3/1115 38/18722 0.396322722627589 0.663520544405362 TECR/ACSL3/ELOVL1 3 GO:0048246 macrophage chemotaxis 3/1115 38/18722 0.396322722627589 0.663520544405362 MIF/TRPV4/EDNRB 3 GO:0048713 regulation of oligodendrocyte differentiation 3/1115 38/18722 0.396322722627589 0.663520544405362 DAG1/NF1/CTNNB1 3 GO:0071173 spindle assembly checkpoint signaling 3/1115 38/18722 0.396322722627589 0.663520544405362 TPR/ZNF207/ATM 3 GO:0071174 mitotic spindle checkpoint signaling 3/1115 38/18722 0.396322722627589 0.663520544405362 TPR/ZNF207/ATM 3 GO:1901186 positive regulation of ERBB signaling pathway 3/1115 38/18722 0.396322722627589 0.663520544405362 RTN4/RBPJ/ADAM17 3 GO:0072330 monocarboxylic acid biosynthetic process 14/1115 214/18722 0.397819871299682 0.665818273626646 ANXA1/HACD3/SLC27A2/MIF/CD74/ACSS1/PTGES3/GSTP1/DEGS1/TECR/ABCD3/ACSL3/ELOVL1/FASN 14 GO:0006929 substrate-dependent cell migration 2/1115 23/18722 0.401681081646381 0.668716961306525 NRP1/FN1 2 GO:0031280 negative regulation of cyclase activity 2/1115 23/18722 0.401681081646381 0.668716961306525 AKAP9/EDNRB 2 GO:0034105 positive regulation of tissue remodeling 2/1115 23/18722 0.401681081646381 0.668716961306525 ROCK1/PPP3CA 2 GO:0035162 embryonic hemopoiesis 2/1115 23/18722 0.401681081646381 0.668716961306525 PBX1/KMT2A 2 GO:0035812 renal sodium excretion 2/1115 23/18722 0.401681081646381 0.668716961306525 ATP6V1B1/EDNRB 2 GO:0035988 chondrocyte proliferation 2/1115 23/18722 0.401681081646381 0.668716961306525 GOLGB1/BMPR2 2 GO:0042026 protein refolding 2/1115 23/18722 0.401681081646381 0.668716961306525 HSPA5/HSPA1A 2 GO:0043931 ossification involved in bone maturation 2/1115 23/18722 0.401681081646381 0.668716961306525 PLXNB1/RHOA 2 GO:0045723 positive regulation of fatty acid biosynthetic process 2/1115 23/18722 0.401681081646381 0.668716961306525 ANXA1/CD74 2 GO:0045943 positive regulation of transcription by RNA polymerase I 2/1115 23/18722 0.401681081646381 0.668716961306525 NCL/ERBB2 2 GO:0051590 positive regulation of neurotransmitter transport 2/1115 23/18722 0.401681081646381 0.668716961306525 ITGB1/RAB3GAP1 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/1115 23/18722 0.401681081646381 0.668716961306525 AKAP9/GJA5 2 GO:0060353 regulation of cell adhesion molecule production 2/1115 23/18722 0.401681081646381 0.668716961306525 COLEC12/CAV1 2 GO:0060384 innervation 2/1115 23/18722 0.401681081646381 0.668716961306525 NRP1/ISL1 2 GO:0060487 lung epithelial cell differentiation 2/1115 23/18722 0.401681081646381 0.668716961306525 RBPJ/NFIB 2 GO:0060547 negative regulation of necrotic cell death 2/1115 23/18722 0.401681081646381 0.668716961306525 CAV1/YBX3 2 GO:2001169 regulation of ATP biosynthetic process 2/1115 23/18722 0.401681081646381 0.668716961306525 ENO1/TMSB4X 2 GO:0010524 positive regulation of calcium ion transport into cytosol 4/1115 54/18722 0.402524418147702 0.669077792182622 CALM1/P2RX4/CAV1/PKD2 4 GO:0014888 striated muscle adaptation 4/1115 54/18722 0.402524418147702 0.669077792182622 ATP2B4/ATP2A2/CFLAR/PPP3CA 4 GO:0035065 regulation of histone acetylation 4/1115 54/18722 0.402524418147702 0.669077792182622 RPS6KA5/ZNF451/KMT2A/ISL1 4 GO:0060350 endochondral bone morphogenesis 4/1115 54/18722 0.402524418147702 0.669077792182622 TRIP11/TRPV4/BMPR2/TSKU 4 GO:0070228 regulation of lymphocyte apoptotic process 4/1115 54/18722 0.402524418147702 0.669077792182622 SLC39A10/CD74/DOCK8/FOXP1 4 GO:0070665 positive regulation of leukocyte proliferation 10/1115 150/18722 0.403424514738894 0.670365230062544 CD46/IL6ST/ANXA1/SLC39A10/MIF/CD74/RPS3/TFRC/VAV3/HMGB1 10 GO:0032147 activation of protein kinase activity 9/1115 134/18722 0.404553322315354 0.672031794599153 PRLR/PPIA/DLG1/WNK1/HMGB1/OSBPL8/INSR/EFNA5/TLR3 9 GO:0002548 monocyte chemotaxis 5/1115 70/18722 0.405127850149369 0.67256765918765 ANXA1/FLT1/LGMN/ANO6/HMGB1 5 GO:0045123 cellular extravasation 5/1115 70/18722 0.405127850149369 0.67256765918765 ITGB1/ROCK1/CD47/F11R/PDGFD 5 GO:0009308 amine metabolic process 8/1115 118/18722 0.405458164602059 0.672906789185698 ATP2B4/OAZ1/SMS/AOC1/SLC44A1/CLN3/LY6E/SAT1 8 GO:0032677 regulation of interleukin-8 production 7/1115 102/18722 0.406019766640915 0.673445015072928 ANXA1/CD74/TMSB4X/HMGB1/TLR3/MAVS/HSPA1A 7 GO:0032413 negative regulation of ion transmembrane transporter activity 6/1115 86/18722 0.406034744993399 0.673445015072928 CALM1/ANK3/YWHAE/C4orf3/CAV1/PKD2 6 GO:0007059 chromosome segregation 22/1115 346/18722 0.406744158266345 0.674412130740377 NIPBL/ATRX/RPS3/NR3C1/TPR/EML4/USP9X/DYNC1H1/TOP2B/PUM2/KPNB1/PUM1/PDS5B/RAN/ZNF207/ATM/UBE2C/NUSAP1/CTNNB1/CDC20/BIRC5/MLH3 22 GO:0006163 purine nucleotide metabolic process 25/1115 396/18722 0.410779096651814 0.68089090252221 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RAN/ACSL3/INSR/PDE10A/PDE7A/ELOVL1/FASN/GPAT4/RHOA 25 GO:0051607 defense response to virus 17/1115 265/18722 0.411533903052088 0.68171874290881 DDX17/IL10RB/PCBP2/SERINC3/TRIM56/IFI6/TRIM44/PUM2/SKP2/DNAJC3/DHX36/SETD2/PUM1/TLR3/MOV10/ANKRD17/MAVS 17 GO:0140546 defense response to symbiont 17/1115 265/18722 0.411533903052088 0.68171874290881 DDX17/IL10RB/PCBP2/SERINC3/TRIM56/IFI6/TRIM44/PUM2/SKP2/DNAJC3/DHX36/SETD2/PUM1/TLR3/MOV10/ANKRD17/MAVS 17 GO:0002347 response to tumor cell 3/1115 39/18722 0.412623075409959 0.68204167170705 RBMS3/HMGB1/MR1 3 GO:0031577 spindle checkpoint signaling 3/1115 39/18722 0.412623075409959 0.68204167170705 TPR/ZNF207/ATM 3 GO:0032506 cytokinetic process 3/1115 39/18722 0.412623075409959 0.68204167170705 PLEC/SNX18/RHOA 3 GO:0045823 positive regulation of heart contraction 3/1115 39/18722 0.412623075409959 0.68204167170705 ADRB1/ATP2A2/ATP1A1 3 GO:1902742 apoptotic process involved in development 3/1115 39/18722 0.412623075409959 0.68204167170705 LRP5/BMP7/FZD5 3 GO:2000249 regulation of actin cytoskeleton reorganization 3/1115 39/18722 0.412623075409959 0.68204167170705 IQGAP2/NRP1/F11R 3 GO:2000785 regulation of autophagosome assembly 3/1115 39/18722 0.412623075409959 0.68204167170705 C9orf72/RAB3GAP1/RAB3GAP2 3 GO:0046883 regulation of hormone secretion 16/1115 249/18722 0.413693390002114 0.683387688496685 EGFR/LRP1/ANXA1/LRP5/DPP4/DYNLL1/GJA1/SYT7/SLC16A1/TCF7L2/KIF5B/C1QTNF1/EFNA5/PPP3CA/REST/ISL1 16 GO:1901988 negative regulation of cell cycle phase transition 16/1115 249/18722 0.413693390002114 0.683387688496685 ZFP36L1/PRKDC/TPR/USP47/RPL26/TAOK1/DLG1/TAOK3/JADE1/MAPK14/CCND1/ZNF207/FEM1B/PKD2/FOXO4/ATM 16 GO:0019395 fatty acid oxidation 7/1115 103/18722 0.415902128919863 0.685774728724955 SLC27A2/CROT/ECHDC2/CPT2/MAPK14/ABCD3/ACOX1 7 GO:0032637 interleukin-8 production 7/1115 103/18722 0.415902128919863 0.685774728724955 ANXA1/CD74/TMSB4X/HMGB1/TLR3/MAVS/HSPA1A 7 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 7/1115 103/18722 0.415902128919863 0.685774728724955 CSH1/PRLR/IL10RB/PARP14/CAV1/SUZ12/OCIAD2 7 GO:0090277 positive regulation of peptide hormone secretion 7/1115 103/18722 0.415902128919863 0.685774728724955 EGFR/LRP1/DYNLL1/GJA1/TCF7L2/KIF5B/ISL1 7 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 15/1115 233/18722 0.415902818129639 0.685774728724955 ADGRG1/LGR5/PSAP/LGR4/ABCA1/ADRB1/ATP2B4/GNAQ/GNA12/AKAP13/ADCY7/S1PR2/S1PR3/RAPGEF2/WASF2 15 GO:0002067 glandular epithelial cell differentiation 4/1115 55/18722 0.416165971355844 0.685774728724955 CDK6/FGFR2/FASN/GPAT4 4 GO:0038066 p38MAPK cascade 4/1115 55/18722 0.416165971355844 0.685774728724955 ZFP36L1/DLG1/EMC10/MAPK14 4 GO:1905517 macrophage migration 4/1115 55/18722 0.416165971355844 0.685774728724955 MIF/P2RX4/TRPV4/EDNRB 4 GO:0001776 leukocyte homeostasis 6/1115 87/18722 0.416810506768411 0.686413107845943 ANXA1/RPS6/CD74/ADAM17/HMGB1/RC3H1 6 GO:1903578 regulation of ATP metabolic process 6/1115 87/18722 0.416810506768411 0.686413107845943 APP/NCOR1/ENO1/TMSB4X/INSR/RHOA 6 GO:0008344 adult locomotory behavior 5/1115 71/18722 0.417088681060305 0.686659410478252 APP/NPC1/CLCN3/PUM1/OXR1 5 GO:0001779 natural killer cell differentiation 2/1115 24/18722 0.422826535556662 0.691627105801783 PBX1/HECTD1 2 GO:0002021 response to dietary excess 2/1115 24/18722 0.422826535556662 0.691627105801783 ADRB1/TRPV4 2 GO:0010155 regulation of proton transport 2/1115 24/18722 0.422826535556662 0.691627105801783 ACTN4/TMSB4X 2 GO:0010226 response to lithium ion 2/1115 24/18722 0.422826535556662 0.691627105801783 CDH1/ADCY7 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/1115 24/18722 0.422826535556662 0.691627105801783 ENO1/TMSB4X 2 GO:0031639 plasminogen activation 2/1115 24/18722 0.422826535556662 0.691627105801783 ENO1/DHCR24 2 GO:0033032 regulation of myeloid cell apoptotic process 2/1115 24/18722 0.422826535556662 0.691627105801783 ANXA1/ADAM17 2 GO:0036010 protein localization to endosome 2/1115 24/18722 0.422826535556662 0.691627105801783 NRP1/TMEM30A 2 GO:0044321 response to leptin 2/1115 24/18722 0.422826535556662 0.691627105801783 LRP2/CCND1 2 GO:0048011 neurotrophin TRK receptor signaling pathway 2/1115 24/18722 0.422826535556662 0.691627105801783 ZDHHC17/CYFIP2 2 GO:0048641 regulation of skeletal muscle tissue development 2/1115 24/18722 0.422826535556662 0.691627105801783 CTNNB1/YBX3 2 GO:0050855 regulation of B cell receptor signaling pathway 2/1115 24/18722 0.422826535556662 0.691627105801783 SLC39A10/FOXP1 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/1115 24/18722 0.422826535556662 0.691627105801783 FURIN/ROCK1 2 GO:0051123 RNA polymerase II preinitiation complex assembly 2/1115 24/18722 0.422826535556662 0.691627105801783 HMGB1/ATF7IP 2 GO:0051156 glucose 6-phosphate metabolic process 2/1115 24/18722 0.422826535556662 0.691627105801783 G6PC3/TKT 2 GO:0071676 negative regulation of mononuclear cell migration 2/1115 24/18722 0.422826535556662 0.691627105801783 MIA3/WASL 2 GO:0072010 glomerular epithelium development 2/1115 24/18722 0.422826535556662 0.691627105801783 IQGAP1/JAG1 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/1115 24/18722 0.422826535556662 0.691627105801783 ENO1/TMSB4X 2 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 2/1115 24/18722 0.422826535556662 0.691627105801783 SLC5A3/CLCN3 2 GO:2000209 regulation of anoikis 2/1115 24/18722 0.422826535556662 0.691627105801783 ITGB1/CAV1 2 GO:2000353 positive regulation of endothelial cell apoptotic process 2/1115 24/18722 0.422826535556662 0.691627105801783 ANO6/PRKCI 2 GO:0006304 DNA modification 8/1115 120/18722 0.423806763237569 0.693018165061372 ATRX/DNMT3A/TET2/USP9X/MPHOSPH8/KMT2A/ATF7IP/TDG 8 GO:0000075 cell cycle checkpoint signaling 11/1115 169/18722 0.425295327662471 0.695239361417615 PRKDC/TPR/RPL26/TAOK1/TAOK3/MAPK14/CCND1/ZNF207/FEM1B/FOXO4/ATM 11 GO:0022600 digestive system process 7/1115 104/18722 0.425771304085829 0.695804405422174 COPA/KCNN4/SLC22A5/IREB2/WNK1/F11R/LPCAT3 7 GO:0019722 calcium-mediated signaling 13/1115 202/18722 0.427544382730775 0.697585713254451 EGFR/ATP2B4/CALM1/NFAT5/P2RX4/SLC9A1/ATP2A2/PPP1R9A/DMD/NFATC3/EDNRB/PPP3CA/MCTP2 13 GO:0007260 tyrosine phosphorylation of STAT protein 6/1115 88/18722 0.427562940934118 0.697585713254451 IL6ST/CSH1/PARP14/CAV1/SUZ12/ISL1 6 GO:0009144 purine nucleoside triphosphate metabolic process 6/1115 88/18722 0.427562940934118 0.697585713254451 ALDOA/ENO1/TMSB4X/AK3/RAN/RHOA 6 GO:0007339 binding of sperm to zona pellucida 3/1115 40/18722 0.428781899446874 0.697585713254451 ALDOA/B4GALT1/CCT3 3 GO:0009187 cyclic nucleotide metabolic process 3/1115 40/18722 0.428781899446874 0.697585713254451 ADCY7/PDE10A/PDE7A 3 GO:0010543 regulation of platelet activation 3/1115 40/18722 0.428781899446874 0.697585713254451 IL6ST/F11R/C1QTNF1 3 GO:0010863 positive regulation of phospholipase C activity 3/1115 40/18722 0.428781899446874 0.697585713254451 EGFR/FLT1/GNAQ 3 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 3/1115 40/18722 0.428781899446874 0.697585713254451 TPR/ZNF207/ATM 3 GO:0046365 monosaccharide catabolic process 3/1115 40/18722 0.428781899446874 0.697585713254451 LRP5/GLB1/ENO1 3 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 3/1115 40/18722 0.428781899446874 0.697585713254451 NFAT5/ZDHHC21/RHOA 3 GO:2000781 positive regulation of double-strand break repair 3/1115 40/18722 0.428781899446874 0.697585713254451 PRKDC/RIF1/FUS 3 GO:0002534 cytokine production involved in inflammatory response 5/1115 72/18722 0.429009253832299 0.697585713254451 PLD3/ADCY7/CHID1/MAPK14/APPL1 5 GO:0050709 negative regulation of protein secretion 5/1115 72/18722 0.429009253832299 0.697585713254451 ANXA1/FRMD4A/PPP3CA/REST/RHBDF1 5 GO:0051057 positive regulation of small GTPase mediated signal transduction 5/1115 72/18722 0.429009253832299 0.697585713254451 ADGRG1/ITGAV/NET1/AKAP13/F11R 5 GO:1900015 regulation of cytokine production involved in inflammatory response 5/1115 72/18722 0.429009253832299 0.697585713254451 PLD3/ADCY7/CHID1/MAPK14/APPL1 5 GO:0002090 regulation of receptor internalization 4/1115 56/18722 0.42973579526014 0.697585713254451 SCYL2/AHI1/INSR/MKLN1 4 GO:0031529 ruffle organization 4/1115 56/18722 0.42973579526014 0.697585713254451 KANK1/PFN1/COBL/CAV1 4 GO:0043388 positive regulation of DNA binding 4/1115 56/18722 0.42973579526014 0.697585713254451 CALM1/HMGB1/ISL1/CTNNB1 4 GO:0046456 icosanoid biosynthetic process 4/1115 56/18722 0.42973579526014 0.697585713254451 ANXA1/MIF/CD74/PTGES3 4 GO:0048008 platelet-derived growth factor receptor signaling pathway 4/1115 56/18722 0.42973579526014 0.697585713254451 LRP1/NRP1/PDGFD/ARID5B 4 GO:0051784 negative regulation of nuclear division 4/1115 56/18722 0.42973579526014 0.697585713254451 BMP7/TPR/ZNF207/ATM 4 GO:0070534 protein K63-linked ubiquitination 4/1115 56/18722 0.42973579526014 0.697585713254451 HECTD1/UBR5/TRIM56/TRIP12 4 GO:0071706 tumor necrosis factor superfamily cytokine production 12/1115 186/18722 0.43022596302574 0.697737787903382 APP/DICER1/MIF/GSTP1/CD47/FZD5/HSPB1/FOXP1/HMGB1/TLR3/ISL1/MAVS 12 GO:1902115 regulation of organelle assembly 12/1115 186/18722 0.43022596302574 0.697737787903382 NPM1/TPR/CDKL5/DYNC1H1/CNOT6L/C9orf72/SENP6/RAB3GAP1/RAB3GAP2/ASAP1/HSPA1A/RHOA 12 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 12/1115 186/18722 0.43022596302574 0.697737787903382 APP/DICER1/MIF/GSTP1/CD47/FZD5/HSPB1/FOXP1/HMGB1/TLR3/ISL1/MAVS 12 GO:0060078 regulation of postsynaptic membrane potential 9/1115 137/18722 0.43035222617828 0.697737787903382 APP/ADRB1/GABRE/P2RX4/PPP1R9A/SLC29A1/RAB3GAP1/S1PR2/PPP3CA 9 GO:0071805 potassium ion transmembrane transport 14/1115 219/18722 0.43174664229716 0.699786072624328 AKAP9/ITGB1/ANO6/ANK3/YWHAE/SLC9A1/DLG1/KCNN4/SLC1A3/ATP1A1/WNK1/CAV1/ALG10B/PKD2 14 GO:0007259 receptor signaling pathway via JAK-STAT 11/1115 170/18722 0.433010235051083 0.701621136551663 IL6ST/CSH1/PRLR/IL10RB/PARP14/PIAS1/CAV1/SUZ12/PKD2/ISL1/OCIAD2 11 GO:0070661 leukocyte proliferation 20/1115 318/18722 0.433502659111047 0.702205915350084 CD46/IL6ST/ANXA1/RPS6/SLC39A10/MIF/CD74/RPS3/DOCK8/DLG5/DLG1/GSTP1/TFRC/NCSTN/VAV3/HMGB1/RC3H1/ATM/ERBB2/CTNNB1 20 GO:0002683 negative regulation of immune system process 27/1115 434/18722 0.435575076335864 0.705348902807758 FBN1/CD46/GRN/ANXA1/CDK6/MIF/DPP4/CD74/PRKDC/FURIN/DLG5/DLG1/PCBP2/CD47/PARP14/GLI3/MIA3/WASL/HMGB1/MAPK14/APPL1/TLR3/RC3H1/SERPINB9/ATM/ERBB2/CTNNB1 27 GO:0009199 ribonucleoside triphosphate metabolic process 6/1115 89/18722 0.438284632446557 0.709521422872095 ALDOA/ENO1/TMSB4X/AK3/RAN/RHOA 6 GO:0042129 regulation of T cell proliferation 11/1115 171/18722 0.440719528422352 0.710342134788328 CD46/IL6ST/ANXA1/RPS3/DLG5/DLG1/TFRC/HMGB1/RC3H1/ERBB2/CTNNB1 11 GO:0048469 cell maturation 11/1115 171/18722 0.440719528422352 0.710342134788328 APP/NRCAM/B4GALT5/FZD5/CLN5/PTBP3/TFCP2L1/FEM1B/EDNRB/CTNNB1/GPAT4 11 GO:0051048 negative regulation of secretion 11/1115 171/18722 0.440719528422352 0.710342134788328 ANXA1/CD74/GJA1/ERBB3/PPP1R9A/FRMD4A/WNK1/PPP3CA/REST/RHBDF1/PLA2R1 11 GO:0032732 positive regulation of interleukin-1 production 5/1115 73/18722 0.440879820732074 0.710342134788328 APP/FZD5/HSPB1/HMGB1/ISL1 5 GO:0050848 regulation of calcium-mediated signaling 5/1115 73/18722 0.440879820732074 0.710342134788328 ATP2B4/CALM1/NFAT5/P2RX4/SLC9A1 5 GO:1903037 regulation of leukocyte cell-cell adhesion 21/1115 336/18722 0.441815171539607 0.710342134788328 CD46/IL6ST/ANXA1/DPP4/CD74/NFAT5/RPS3/DOCK8/DLG5/DLG1/CD47/TFRC/WNK1/GLI3/MIA3/HMGB1/CAV1/ZDHHC21/RC3H1/ERBB2/RHOA 21 GO:0050868 negative regulation of T cell activation 8/1115 122/18722 0.442109632868501 0.710342134788328 ANXA1/CD74/DLG5/DLG1/GLI3/HMGB1/RC3H1/ERBB2 8 GO:0051208 sequestering of calcium ion 8/1115 122/18722 0.442109632868501 0.710342134788328 HSP90B1/CALM1/ITPR2/MCOLN3/DMD/PKD2/IBTK/ATP7B 8 GO:0051928 positive regulation of calcium ion transport 8/1115 122/18722 0.442109632868501 0.710342134788328 ATP2B1/CALM1/P2RX4/SLC9A1/CAV1/PKD2/VMP1/WFS1 8 GO:0034205 amyloid-beta formation 4/1115 57/18722 0.443220329226483 0.710342134788328 RTN4/ADAM10/ROCK1/NCSTN 4 GO:0051785 positive regulation of nuclear division 4/1115 57/18722 0.443220329226483 0.710342134788328 LRP5/PHIP/INSR/NUSAP1 4 GO:0003094 glomerular filtration 2/1115 25/18722 0.443577946701065 0.710342134788328 GJA1/GJA5 2 GO:0010954 positive regulation of protein processing 2/1115 25/18722 0.443577946701065 0.710342134788328 ENO1/LPCAT3 2 GO:0010996 response to auditory stimulus 2/1115 25/18722 0.443577946701065 0.710342134788328 USP53/SLC1A3 2 GO:0015874 norepinephrine transport 2/1115 25/18722 0.443577946701065 0.710342134788328 NISCH/ACTB 2 GO:0030318 melanocyte differentiation 2/1115 25/18722 0.443577946701065 0.710342134788328 GLI3/EDNRB 2 GO:0032925 regulation of activin receptor signaling pathway 2/1115 25/18722 0.443577946701065 0.710342134788328 SMAD2/ACVR2B 2 GO:0033233 regulation of protein sumoylation 2/1115 25/18722 0.443577946701065 0.710342134788328 PIAS1/CTNNB1 2 GO:0033622 integrin activation 2/1115 25/18722 0.443577946701065 0.710342134788328 FN1/FERMT1 2 GO:0036315 cellular response to sterol 2/1115 25/18722 0.443577946701065 0.710342134788328 DAG1/ABCA1 2 GO:0045822 negative regulation of heart contraction 2/1115 25/18722 0.443577946701065 0.710342134788328 ATP2A2/ATP1A1 2 GO:0046835 carbohydrate phosphorylation 2/1115 25/18722 0.443577946701065 0.710342134788328 GNPTAB/GNE 2 GO:0070199 establishment of protein localization to chromosome 2/1115 25/18722 0.443577946701065 0.710342134788328 NIPBL/CCT3 2 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 2/1115 25/18722 0.443577946701065 0.710342134788328 XIAP/HSPA1A 2 GO:0072202 cell differentiation involved in metanephros development 2/1115 25/18722 0.443577946701065 0.710342134788328 LGR4/CTNNB1 2 GO:0072207 metanephric epithelium development 2/1115 25/18722 0.443577946701065 0.710342134788328 LGR4/PKD2 2 GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/1115 25/18722 0.443577946701065 0.710342134788328 YWHAE/ATP1A1 2 GO:0098703 calcium ion import across plasma membrane 2/1115 25/18722 0.443577946701065 0.710342134788328 ATP2B4/TRPV4 2 GO:0099560 synaptic membrane adhesion 2/1115 25/18722 0.443577946701065 0.710342134788328 PTPRF/MAPK14 2 GO:1903055 positive regulation of extracellular matrix organization 2/1115 25/18722 0.443577946701065 0.710342134788328 DAG1/CFLAR 2 GO:1903901 negative regulation of viral life cycle 2/1115 25/18722 0.443577946701065 0.710342134788328 PPIA/LY6E 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/1115 25/18722 0.443577946701065 0.710342134788328 GNA12/RHOA 2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 2/1115 25/18722 0.443577946701065 0.710342134788328 NFAT5/RHOA 2 GO:1905048 regulation of metallopeptidase activity 2/1115 25/18722 0.443577946701065 0.710342134788328 LRP1/CLDN4 2 GO:0051147 regulation of muscle cell differentiation 10/1115 155/18722 0.444015599321003 0.710342134788328 YBX1/MORF4L2/BMPR2/PIAS1/MAPK14/NFATC3/BMPR1A/FGFR2/ANKRD17/FOXO4 10 GO:0051480 regulation of cytosolic calcium ion concentration 22/1115 353/18722 0.444321276390944 0.710342134788328 LRP1/ATP2B1/ITGAV/ATP2B4/GJA1/CALM1/P2RX4/ITPR2/MCOLN3/YWHAE/GTF2I/DMD/TMEM64/TRPV4/C1QTNF1/CLN3/HMGB1/CAV1/S1PR3/EDNRB/PKD2/IBTK 22 GO:0001953 negative regulation of cell-matrix adhesion 3/1115 41/18722 0.444778751938074 0.710342134788328 LRP1/RASA1/JAG1 3 GO:0050856 regulation of T cell receptor signaling pathway 3/1115 41/18722 0.444778751938074 0.710342134788328 RPS3/KCNN4/RC3H1 3 GO:0050892 intestinal absorption 3/1115 41/18722 0.444778751938074 0.710342134788328 IREB2/F11R/LPCAT3 3 GO:0070296 sarcoplasmic reticulum calcium ion transport 3/1115 41/18722 0.444778751938074 0.710342134788328 CALM1/ATP2A2/DMD 3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 3/1115 41/18722 0.444778751938074 0.710342134788328 NRP1/P4HB/S100A10 3 GO:1901385 regulation of voltage-gated calcium channel activity 3/1115 41/18722 0.444778751938074 0.710342134788328 AHNAK/CALM1/DMD 3 GO:1903524 positive regulation of blood circulation 3/1115 41/18722 0.444778751938074 0.710342134788328 ADRB1/ATP2A2/ATP1A1 3 GO:1905521 regulation of macrophage migration 3/1115 41/18722 0.444778751938074 0.710342134788328 MIF/P2RX4/TRPV4 3 GO:2000008 regulation of protein localization to cell surface 3/1115 41/18722 0.444778751938074 0.710342134788328 HSP90AB1/GPD1L/CTNNB1 3 GO:0002793 positive regulation of peptide secretion 7/1115 106/18722 0.445446744188315 0.710771119910763 EGFR/LRP1/DYNLL1/GJA1/TCF7L2/KIF5B/ISL1 7 GO:0035821 modulation of process of other organism 7/1115 106/18722 0.445446744188315 0.710771119910763 DAG1/CFL1/ANO6/STOM/INSR/REST/SERPINB9 7 GO:0099565 chemical synaptic transmission, postsynaptic 7/1115 106/18722 0.445446744188315 0.710771119910763 APP/P2RX4/PPP1R9A/SLC29A1/RAB3GAP1/S1PR2/PPP3CA 7 GO:0045598 regulation of fat cell differentiation 9/1115 139/18722 0.447507240156703 0.71121909282784 LRP5/ZFP36L1/BMP7/ADIRF/CDS1/JAG1/TMEM64/TRPV4/MAPK14 9 GO:0001678 cellular glucose homeostasis 11/1115 172/18722 0.44842037095037 0.71121909282784 LRP1/LRP5/IGF1R/DYNLL1/SERPINF1/CCDC186/KIF5B/SLC29A1/EFNA5/PPP3CA/TRA2B 11 GO:0045638 negative regulation of myeloid cell differentiation 6/1115 90/18722 0.448968401427663 0.71121909282784 FBN1/CDK6/ZFP36L1/MEIS2/TLR3/CTNNB1 6 GO:0070664 negative regulation of leukocyte proliferation 6/1115 90/18722 0.448968401427663 0.71121909282784 DLG5/DLG1/GSTP1/RC3H1/ATM/ERBB2 6 GO:0042110 T cell activation 30/1115 487/18722 0.451018057897313 0.71121909282784 CD46/IL6ST/ANXA1/RPS6/ZFP36L1/DPP4/CD74/PRKDC/RPS3/DOCK8/DLG5/DLG1/CD47/TFRC/FZD5/NCSTN/ADAM17/GLI3/FOXP1/HMGB1/PTPRK/CAV1/PPP3CA/CLPTM1/RC3H1/ERBB2/MR1/CTNNB1/RHOA/SOD1 30 GO:0006690 icosanoid metabolic process 8/1115 123/18722 0.451232241380131 0.71121909282784 ANXA1/MIF/CD74/PTGES3/ATP6V1B1/GSTP1/ACOX1/HPGD 8 GO:0006338 chromatin remodeling 16/1115 255/18722 0.451680248488745 0.71121909282784 NPM1/ATRX/SMARCA2/BPTF/ARID1A/RSF1/PBRM1/KDM5A/BAZ2B/SMARCC1/JARID2/SETD2/ACTB/HNRNPC/SHPRH/RERE 16 GO:0051924 regulation of calcium ion transport 16/1115 255/18722 0.451680248488745 0.71121909282784 AHNAK/ATP2B1/GJA1/CALM1/P2RX4/YWHAE/SLC9A1/C4orf3/VDAC1/DMD/CAV1/PKD2/VMP1/CTNNB1/WFS1/RHOA 16 GO:0051881 regulation of mitochondrial membrane potential 5/1115 74/18722 0.452691033920976 0.71121909282784 ARL6IP5/IFI6/SLC25A36/PRDX3/SOD1 5 GO:0051341 regulation of oxidoreductase activity 7/1115 107/18722 0.455241712207202 0.71121909282784 EGFR/ATP2B4/CALM1/PDP2/CAV1/ZDHHC21/HM13 7 GO:0006694 steroid biosynthetic process 11/1115 173/18722 0.456109968828621 0.71121909282784 PBX1/PRLR/SLC27A2/ASAH1/SF1/ATP1A1/DHCR24/ABCD3/LPCAT3/REST/SOD1 11 GO:0032387 negative regulation of intracellular transport 4/1115 58/18722 0.456606770502962 0.71121909282784 LMAN1/TPR/ERLEC1/FERMT1 4 GO:0043525 positive regulation of neuron apoptotic process 4/1115 58/18722 0.456606770502962 0.71121909282784 GRN/NF1/CTNNB1/RHOA 4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA 1/1115 10/18722 0.458915485070595 0.71121909282784 DCP2 1 GO:0001820 serotonin secretion 1/1115 10/18722 0.458915485070595 0.71121909282784 SLC6A4 1 GO:0002084 protein depalmitoylation 1/1115 10/18722 0.458915485070595 0.71121909282784 LYPLA1 1 GO:0003163 sinoatrial node development 1/1115 10/18722 0.458915485070595 0.71121909282784 ISL1 1 GO:0006171 cAMP biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 ADCY7 1 GO:0006735 NADH regeneration 1/1115 10/18722 0.458915485070595 0.71121909282784 ENO1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 AK3 1 GO:0009750 response to fructose 1/1115 10/18722 0.458915485070595 0.71121909282784 KRT18 1 GO:0010172 embryonic body morphogenesis 1/1115 10/18722 0.458915485070595 0.71121909282784 DAG1 1 GO:0010968 regulation of microtubule nucleation 1/1115 10/18722 0.458915485070595 0.71121909282784 HSPA1A 1 GO:0010992 ubiquitin recycling 1/1115 10/18722 0.458915485070595 0.71121909282784 UBE2C 1 GO:0014041 regulation of neuron maturation 1/1115 10/18722 0.458915485070595 0.71121909282784 EDNRB 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/1115 10/18722 0.458915485070595 0.71121909282784 SLC2A1 1 GO:0019062 virion attachment to host cell 1/1115 10/18722 0.458915485070595 0.71121909282784 HSP90AB1 1 GO:0019532 oxalate transport 1/1115 10/18722 0.458915485070595 0.71121909282784 SLC26A2 1 GO:0030300 regulation of intestinal cholesterol absorption 1/1115 10/18722 0.458915485070595 0.71121909282784 LPCAT3 1 GO:0030388 fructose 1,6-bisphosphate metabolic process 1/1115 10/18722 0.458915485070595 0.71121909282784 ALDOA 1 GO:0031125 rRNA 3'-end processing 1/1115 10/18722 0.458915485070595 0.71121909282784 RPS21 1 GO:0031642 negative regulation of myelination 1/1115 10/18722 0.458915485070595 0.71121909282784 CTSC 1 GO:0031915 positive regulation of synaptic plasticity 1/1115 10/18722 0.458915485070595 0.71121909282784 CDC20 1 GO:0032025 response to cobalt ion 1/1115 10/18722 0.458915485070595 0.71121909282784 SERPINF1 1 GO:0032253 dense core granule localization 1/1115 10/18722 0.458915485070595 0.71121909282784 KIF5B 1 GO:0032342 aldosterone biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 REST 1 GO:0032380 regulation of intracellular sterol transport 1/1115 10/18722 0.458915485070595 0.71121909282784 ANXA2 1 GO:0032383 regulation of intracellular cholesterol transport 1/1115 10/18722 0.458915485070595 0.71121909282784 ANXA2 1 GO:0033080 immature T cell proliferation in thymus 1/1115 10/18722 0.458915485070595 0.71121909282784 ERBB2 1 GO:0033131 regulation of glucokinase activity 1/1115 10/18722 0.458915485070595 0.71121909282784 RANBP2 1 GO:0034085 establishment of sister chromatid cohesion 1/1115 10/18722 0.458915485070595 0.71121909282784 NIPBL 1 GO:0034651 cortisol biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 REST 1 GO:0035376 sterol import 1/1115 10/18722 0.458915485070595 0.71121909282784 LRP1 1 GO:0035520 monoubiquitinated protein deubiquitination 1/1115 10/18722 0.458915485070595 0.71121909282784 USP47 1 GO:0036109 alpha-linolenic acid metabolic process 1/1115 10/18722 0.458915485070595 0.71121909282784 ELOVL1 1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling 1/1115 10/18722 0.458915485070595 0.71121909282784 LPCAT3 1 GO:0043084 penile erection 1/1115 10/18722 0.458915485070595 0.71121909282784 EDNRB 1 GO:0044351 macropinocytosis 1/1115 10/18722 0.458915485070595 0.71121909282784 APPL1 1 GO:0044557 relaxation of smooth muscle 1/1115 10/18722 0.458915485070595 0.71121909282784 SOD1 1 GO:0045625 regulation of T-helper 1 cell differentiation 1/1115 10/18722 0.458915485070595 0.71121909282784 ANXA1 1 GO:0045792 negative regulation of cell size 1/1115 10/18722 0.458915485070595 0.71121909282784 RHOA 1 GO:0045843 negative regulation of striated muscle tissue development 1/1115 10/18722 0.458915485070595 0.71121909282784 YBX3 1 GO:0048194 Golgi vesicle budding 1/1115 10/18722 0.458915485070595 0.71121909282784 PRKCI 1 GO:0048241 epinephrine transport 1/1115 10/18722 0.458915485070595 0.71121909282784 LY6E 1 GO:0048251 elastic fiber assembly 1/1115 10/18722 0.458915485070595 0.71121909282784 LTBP3 1 GO:0048262 determination of dorsal/ventral asymmetry 1/1115 10/18722 0.458915485070595 0.71121909282784 CTNNB1 1 GO:0048672 positive regulation of collateral sprouting 1/1115 10/18722 0.458915485070595 0.71121909282784 LRP1 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/1115 10/18722 0.458915485070595 0.71121909282784 CALM1 1 GO:0051351 positive regulation of ligase activity 1/1115 10/18722 0.458915485070595 0.71121909282784 TMSB4X 1 GO:0051660 establishment of centrosome localization 1/1115 10/18722 0.458915485070595 0.71121909282784 DLG1 1 GO:0060068 vagina development 1/1115 10/18722 0.458915485070595 0.71121909282784 LRP2 1 GO:0060439 trachea morphogenesis 1/1115 10/18722 0.458915485070595 0.71121909282784 CTNNB1 1 GO:0060513 prostatic bud formation 1/1115 10/18722 0.458915485070595 0.71121909282784 BMP7 1 GO:0060525 prostate glandular acinus development 1/1115 10/18722 0.458915485070595 0.71121909282784 FGFR2 1 GO:0060923 cardiac muscle cell fate commitment 1/1115 10/18722 0.458915485070595 0.71121909282784 RBPJ 1 GO:0061140 lung secretory cell differentiation 1/1115 10/18722 0.458915485070595 0.71121909282784 NFIB 1 GO:0061621 canonical glycolysis 1/1115 10/18722 0.458915485070595 0.71121909282784 ENO1 1 GO:0061718 glucose catabolic process to pyruvate 1/1115 10/18722 0.458915485070595 0.71121909282784 ENO1 1 GO:0070091 glucagon secretion 1/1115 10/18722 0.458915485070595 0.71121909282784 SYT7 1 GO:0070092 regulation of glucagon secretion 1/1115 10/18722 0.458915485070595 0.71121909282784 SYT7 1 GO:0070391 response to lipoteichoic acid 1/1115 10/18722 0.458915485070595 0.71121909282784 MAPK14 1 GO:0070508 cholesterol import 1/1115 10/18722 0.458915485070595 0.71121909282784 LRP1 1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/1115 10/18722 0.458915485070595 0.71121909282784 ERLEC1 1 GO:0071073 positive regulation of phospholipid biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 ACSL3 1 GO:0071223 cellular response to lipoteichoic acid 1/1115 10/18722 0.458915485070595 0.71121909282784 MAPK14 1 GO:0071421 manganese ion transmembrane transport 1/1115 10/18722 0.458915485070595 0.71121909282784 SLC11A2 1 GO:0071600 otic vesicle morphogenesis 1/1115 10/18722 0.458915485070595 0.71121909282784 FGFR2 1 GO:0071838 cell proliferation in bone marrow 1/1115 10/18722 0.458915485070595 0.71121909282784 FGFR2 1 GO:0097278 complement-dependent cytotoxicity 1/1115 10/18722 0.458915485070595 0.71121909282784 HSP90AB1 1 GO:0098903 regulation of membrane repolarization during action potential 1/1115 10/18722 0.458915485070595 0.71121909282784 CAV1 1 GO:0098917 retrograde trans-synaptic signaling 1/1115 10/18722 0.458915485070595 0.71121909282784 DAG1 1 GO:0099519 dense core granule cytoskeletal transport 1/1115 10/18722 0.458915485070595 0.71121909282784 KIF5B 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/1115 10/18722 0.458915485070595 0.71121909282784 ACSL3 1 GO:1901203 positive regulation of extracellular matrix assembly 1/1115 10/18722 0.458915485070595 0.71121909282784 DAG1 1 GO:1901725 regulation of histone deacetylase activity 1/1115 10/18722 0.458915485070595 0.71121909282784 KDM5A 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1115 10/18722 0.458915485070595 0.71121909282784 NCL 1 GO:1901950 dense core granule transport 1/1115 10/18722 0.458915485070595 0.71121909282784 KIF5B 1 GO:1901978 positive regulation of cell cycle checkpoint 1/1115 10/18722 0.458915485070595 0.71121909282784 TPR 1 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/1115 10/18722 0.458915485070595 0.71121909282784 SERINC3 1 GO:1902645 tertiary alcohol biosynthetic process 1/1115 10/18722 0.458915485070595 0.71121909282784 REST 1 GO:1902946 protein localization to early endosome 1/1115 10/18722 0.458915485070595 0.71121909282784 NRP1 1 GO:1903980 positive regulation of microglial cell activation 1/1115 10/18722 0.458915485070595 0.71121909282784 CTSC 1 GO:1904851 positive regulation of establishment of protein localization to telomere 1/1115 10/18722 0.458915485070595 0.71121909282784 CCT3 1 GO:1905651 regulation of artery morphogenesis 1/1115 10/18722 0.458915485070595 0.71121909282784 AKT3 1 GO:2000121 regulation of removal of superoxide radicals 1/1115 10/18722 0.458915485070595 0.71121909282784 BMP7 1 GO:2000425 regulation of apoptotic cell clearance 1/1115 10/18722 0.458915485070595 0.71121909282784 HMGB1 1 GO:2000434 regulation of protein neddylation 1/1115 10/18722 0.458915485070595 0.71121909282784 RPL5 1 GO:2001223 negative regulation of neuron migration 1/1115 10/18722 0.458915485070595 0.71121909282784 ADGRG1 1 GO:2001225 regulation of chloride transport 1/1115 10/18722 0.458915485070595 0.71121909282784 GABRE 1 GO:0051983 regulation of chromosome segregation 6/1115 91/18722 0.459607309534546 0.711343988779702 TPR/PUM2/PUM1/ZNF207/ATM/UBE2C 6 GO:0099111 microtubule-based transport 12/1115 190/18722 0.459641062485838 0.711343988779702 APP/DST/ARHGAP21/PCM1/RAB6A/DYNC1H1/KIF5B/LRPPRC/HSPB1/CLN3/TRAK2/SOD1 12 GO:0050804 modulation of chemical synaptic transmission 27/1115 439/18722 0.459802326070318 0.711343988779702 EGFR/AKAP9/CDH1/ITGB1/MME/LGMN/SLC6A4/APP/CALM1/ATP2A2/SYT7/PTPRA/CLSTN1/KIF5B/SLC1A3/PPP1R9A/NCSTN/RAB3GAP1/NISCH/CLN3/RNF19A/S1PR2/PPP3CA/MCTP2/PAIP2/RAPGEF2/CDC20 27 GO:0006040 amino sugar metabolic process 3/1115 42/18722 0.460594899646269 0.711343988779702 EXTL2/GNE/MGAT1 3 GO:0014003 oligodendrocyte development 3/1115 42/18722 0.460594899646269 0.711343988779702 B4GALT5/GSTP1/NCSTN 3 GO:0042168 heme metabolic process 3/1115 42/18722 0.460594899646269 0.711343988779702 SLC11A2/IREB2/NFE2L1 3 GO:0090317 negative regulation of intracellular protein transport 3/1115 42/18722 0.460594899646269 0.711343988779702 LMAN1/ERLEC1/FERMT1 3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 3/1115 42/18722 0.460594899646269 0.711343988779702 CNOT6L/XRN1/DCP2 3 GO:1900274 regulation of phospholipase C activity 3/1115 42/18722 0.460594899646269 0.711343988779702 EGFR/FLT1/GNAQ 3 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 3/1115 42/18722 0.460594899646269 0.711343988779702 TPR/ZNF207/ATM 3 GO:1903432 regulation of TORC1 signaling 3/1115 42/18722 0.460594899646269 0.711343988779702 C9orf72/ITFG2/ATM 3 GO:1904037 positive regulation of epithelial cell apoptotic process 3/1115 42/18722 0.460594899646269 0.711343988779702 ANO6/PRKCI/PLA2R1 3 GO:0002407 dendritic cell chemotaxis 2/1115 26/18722 0.463907233794983 0.71233843003492 ANO6/HMGB1 2 GO:0002418 immune response to tumor cell 2/1115 26/18722 0.463907233794983 0.71233843003492 HMGB1/MR1 2 GO:0003416 endochondral bone growth 2/1115 26/18722 0.463907233794983 0.71233843003492 TSKU/FGFR2 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/1115 26/18722 0.463907233794983 0.71233843003492 BOD1L1/ROCK1 2 GO:0032682 negative regulation of chemokine production 2/1115 26/18722 0.463907233794983 0.71233843003492 GSTP1/SUZ12 2 GO:0033598 mammary gland epithelial cell proliferation 2/1115 26/18722 0.463907233794983 0.71233843003492 RTN4/CCND1 2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/1115 26/18722 0.463907233794983 0.71233843003492 LRPPRC/TRAK2 2 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 2/1115 26/18722 0.463907233794983 0.71233843003492 XIAP/HSPA1A 2 GO:0047497 mitochondrion transport along microtubule 2/1115 26/18722 0.463907233794983 0.71233843003492 LRPPRC/TRAK2 2 GO:0051016 barbed-end actin filament capping 2/1115 26/18722 0.463907233794983 0.71233843003492 SCIN/ADD3 2 GO:0051350 negative regulation of lyase activity 2/1115 26/18722 0.463907233794983 0.71233843003492 AKAP9/EDNRB 2 GO:0070977 bone maturation 2/1115 26/18722 0.463907233794983 0.71233843003492 PLXNB1/RHOA 2 GO:0097066 response to thyroid hormone 2/1115 26/18722 0.463907233794983 0.71233843003492 CTSB/ANXA2 2 GO:0097205 renal filtration 2/1115 26/18722 0.463907233794983 0.71233843003492 GJA1/GJA5 2 GO:1901071 glucosamine-containing compound metabolic process 2/1115 26/18722 0.463907233794983 0.71233843003492 EXTL2/GNE 2 GO:1902186 regulation of viral release from host cell 2/1115 26/18722 0.463907233794983 0.71233843003492 DDB1/TRIM13 2 GO:1902656 calcium ion import into cytosol 2/1115 26/18722 0.463907233794983 0.71233843003492 ATP2B4/TRPV4 2 GO:1903523 negative regulation of blood circulation 2/1115 26/18722 0.463907233794983 0.71233843003492 ATP2A2/ATP1A1 2 GO:1905523 positive regulation of macrophage migration 2/1115 26/18722 0.463907233794983 0.71233843003492 P2RX4/TRPV4 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/1115 26/18722 0.463907233794983 0.71233843003492 ANXA1/RAPGEF2 2 GO:0002292 T cell differentiation involved in immune response 5/1115 75/18722 0.464433950979192 0.712942169142584 CD46/ANXA1/FOXP1/HMGB1/RC3H1 5 GO:0099177 regulation of trans-synaptic signaling 27/1115 440/18722 0.464646260729757 0.712992492295387 EGFR/AKAP9/CDH1/ITGB1/MME/LGMN/SLC6A4/APP/CALM1/ATP2A2/SYT7/PTPRA/CLSTN1/KIF5B/SLC1A3/PPP1R9A/NCSTN/RAB3GAP1/NISCH/CLN3/RNF19A/S1PR2/PPP3CA/MCTP2/PAIP2/RAPGEF2/CDC20 27 GO:0034440 lipid oxidation 7/1115 108/18722 0.465000909940539 0.712992492295387 SLC27A2/CROT/ECHDC2/CPT2/MAPK14/ABCD3/ACOX1 7 GO:0098659 inorganic cation import across plasma membrane 7/1115 108/18722 0.465000909940539 0.712992492295387 SLC39A10/ATP2B4/SLC9A1/DLG1/ATP1A1/WNK1/TRPV4 7 GO:0099587 inorganic ion import across plasma membrane 7/1115 108/18722 0.465000909940539 0.712992492295387 SLC39A10/ATP2B4/SLC9A1/DLG1/ATP1A1/WNK1/TRPV4 7 GO:0055007 cardiac muscle cell differentiation 8/1115 125/18722 0.469397380021805 0.719097484476589 ITGB1/PLEC/SLC9A1/AKAP13/RBPJ/BMPR1A/OBSL1/ISL1 8 GO:0006836 neurotransmitter transport 13/1115 208/18722 0.469821860330235 0.719097484476589 ITGB1/SLC6A4/SLC38A2/CALM1/ATP2A2/SYT7/SLC28A2/SLC38A1/SLC1A3/PPP1R9A/SLC29A1/RAB3GAP1/MCTP2 13 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4/1115 59/18722 0.469883070834285 0.719097484476589 FLT1/NRP1/HSPB1/MAPK14 4 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 4/1115 59/18722 0.469883070834285 0.719097484476589 PARP14/CAV1/SUZ12/IBTK 4 GO:0051055 negative regulation of lipid biosynthetic process 4/1115 59/18722 0.469883070834285 0.719097484476589 ORMDL1/ATP1A1/REST/SOD1 4 GO:2001258 negative regulation of cation channel activity 4/1115 59/18722 0.469883070834285 0.719097484476589 CALM1/ANK3/CAV1/PKD2 4 GO:0032465 regulation of cytokinesis 6/1115 92/18722 0.470194665350772 0.719097484476589 CALM1/BIRC6/PKN2/RAB11FIP4/SETD2/RHOA 6 GO:0034502 protein localization to chromosome 6/1115 92/18722 0.470194665350772 0.719097484476589 NIPBL/ATRX/TNKS2/TPP1/SETD2/CCT3 6 GO:0070509 calcium ion import 6/1115 92/18722 0.470194665350772 0.719097484476589 ATP2B4/ATP2A2/VDAC1/TRPV4/PKD2/CTNNB1 6 GO:0050729 positive regulation of inflammatory response 9/1115 142/18722 0.473096808504969 0.719503930185321 EGFR/NEAT1/IL6ST/GRN/APP/CTSC/CD47/TRPV4/TLR3 9 GO:0006305 DNA alkylation 5/1115 76/18722 0.476100038741485 0.719503930185321 ATRX/DNMT3A/MPHOSPH8/KMT2A/ATF7IP 5 GO:0006306 DNA methylation 5/1115 76/18722 0.476100038741485 0.719503930185321 ATRX/DNMT3A/MPHOSPH8/KMT2A/ATF7IP 5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 5/1115 76/18722 0.476100038741485 0.719503930185321 MIF/CD74/RPL26/RRM2B/EIF5A 5 GO:0001709 cell fate determination 3/1115 43/18722 0.476213260839225 0.719503930185321 JAG1/ISL1/CTNNB1 3 GO:0014014 negative regulation of gliogenesis 3/1115 43/18722 0.476213260839225 0.719503930185321 DICER1/NF1/CTNNB1 3 GO:0033046 negative regulation of sister chromatid segregation 3/1115 43/18722 0.476213260839225 0.719503930185321 TPR/ZNF207/ATM 3 GO:0033048 negative regulation of mitotic sister chromatid segregation 3/1115 43/18722 0.476213260839225 0.719503930185321 TPR/ZNF207/ATM 3 GO:0035794 positive regulation of mitochondrial membrane permeability 3/1115 43/18722 0.476213260839225 0.719503930185321 SLC9A1/SLC35F6/HSPA1A 3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/1115 43/18722 0.476213260839225 0.719503930185321 MIF/CD74/RPL26 3 GO:0045776 negative regulation of blood pressure 3/1115 43/18722 0.476213260839225 0.719503930185321 ADRB1/GJA5/BMPR2 3 GO:2000816 negative regulation of mitotic sister chromatid separation 3/1115 43/18722 0.476213260839225 0.719503930185321 TPR/ZNF207/ATM 3 GO:0031023 microtubule organizing center organization 9/1115 143/18722 0.481573942738834 0.719503930185321 NPM1/GCC2/PCM1/SLC16A1/PPP1R12A/CEP152/RANBP1/PKD2/CTNNB1 9 GO:0070555 response to interleukin-1 9/1115 143/18722 0.481573942738834 0.719503930185321 ANXA1/APP/TFPI/RPS6KA5/CD47/PRKCI/SMPD1/RC3H1/USP10 9 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 12/1115 193/18722 0.481578231175391 0.719503930185321 IL6ST/CSH1/IQGAP1/NRP1/MIF/CD74/ERBB3/RICTOR/PARP14/ADAM17/EFNA5/ISL1 12 GO:0006081 cellular aldehyde metabolic process 4/1115 60/18722 0.48303793012569 0.719503930185321 TPI1/REST/IDH1/TKT 4 GO:0030071 regulation of mitotic metaphase/anaphase transition 4/1115 60/18722 0.48303793012569 0.719503930185321 TPR/ZNF207/ATM/UBE2C 4 GO:0003401 axis elongation 2/1115 27/18722 0.483791051144751 0.719503930185321 FGFR2/PTK7 2 GO:0007026 negative regulation of microtubule depolymerization 2/1115 27/18722 0.483791051144751 0.719503930185321 TAOK1/CAMSAP2 2 GO:0007263 nitric oxide mediated signal transduction 2/1115 27/18722 0.483791051144751 0.719503930185321 EGFR/ATP2B4 2 GO:0007628 adult walking behavior 2/1115 27/18722 0.483791051144751 0.719503930185321 NPC1/OXR1 2 GO:0010561 negative regulation of glycoprotein biosynthetic process 2/1115 27/18722 0.483791051144751 0.719503930185321 ITM2B/AGO2 2 GO:0010758 regulation of macrophage chemotaxis 2/1115 27/18722 0.483791051144751 0.719503930185321 MIF/TRPV4 2 GO:0018904 ether metabolic process 2/1115 27/18722 0.483791051144751 0.719503930185321 NCEH1/FASN 2 GO:0032781 positive regulation of ATPase activity 2/1115 27/18722 0.483791051144751 0.719503930185321 PFN1/TOR1AIP2 2 GO:0034143 regulation of toll-like receptor 4 signaling pathway 2/1115 27/18722 0.483791051144751 0.719503930185321 HMGB1/APPL1 2 GO:0034505 tooth mineralization 2/1115 27/18722 0.483791051144751 0.719503930185321 SLC4A2/ITGB6 2 GO:0035116 embryonic hindlimb morphogenesis 2/1115 27/18722 0.483791051144751 0.719503930185321 GPC3/CTNNB1 2 GO:0035459 vesicle cargo loading 2/1115 27/18722 0.483791051144751 0.719503930185321 SEC31A/MIA3 2 GO:0042104 positive regulation of activated T cell proliferation 2/1115 27/18722 0.483791051144751 0.719503930185321 RPS3/HMGB1 2 GO:0042402 cellular biogenic amine catabolic process 2/1115 27/18722 0.483791051144751 0.719503930185321 SLC44A1/SAT1 2 GO:0045830 positive regulation of isotype switching 2/1115 27/18722 0.483791051144751 0.719503930185321 RIF1/TFRC 2 GO:0046337 phosphatidylethanolamine metabolic process 2/1115 27/18722 0.483791051144751 0.719503930185321 PISD/ETNK1 2 GO:0048873 homeostasis of number of cells within a tissue 2/1115 27/18722 0.483791051144751 0.719503930185321 LIPA/AKT3 2 GO:0051953 negative regulation of amine transport 2/1115 27/18722 0.483791051144751 0.719503930185321 SLC43A2/ARL6IP5 2 GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/1115 27/18722 0.483791051144751 0.719503930185321 MAPK14/CFLAR 2 GO:0060333 interferon-gamma-mediated signaling pathway 2/1115 27/18722 0.483791051144751 0.719503930185321 HSP90AB1/PARP14 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/1115 27/18722 0.483791051144751 0.719503930185321 AKAP9/GJA5 2 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 2/1115 27/18722 0.483791051144751 0.719503930185321 SEMA6A/MYO1C 2 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 2/1115 27/18722 0.483791051144751 0.719503930185321 AKAP9/ALG10B 2 GO:1902883 negative regulation of response to oxidative stress 2/1115 27/18722 0.483791051144751 0.719503930185321 MET/OXR1 2 GO:1903319 positive regulation of protein maturation 2/1115 27/18722 0.483791051144751 0.719503930185321 ENO1/LPCAT3 2 GO:1903421 regulation of synaptic vesicle recycling 2/1115 27/18722 0.483791051144751 0.719503930185321 CALM1/ROCK1 2 GO:0060402 calcium ion transport into cytosol 10/1115 160/18722 0.484297664497207 0.719503930185321 ATP2B4/CALM1/P2RX4/ITPR2/MCOLN3/DMD/TRPV4/CAV1/PKD2/IBTK 10 GO:0018958 phenol-containing compound metabolic process 7/1115 110/18722 0.484391170463583 0.719503930185321 CTSB/GCNT4/LY6E/OPN3/SLC16A2/APPL1/RAPGEF2 7 GO:1901983 regulation of protein acetylation 5/1115 77/18722 0.487681175550665 0.719503930185321 RPS6KA5/TAOK1/ZNF451/KMT2A/ISL1 5 GO:0010821 regulation of mitochondrion organization 9/1115 144/18722 0.490018880852942 0.719503930185321 VPS13C/TFRC/FZD5/VDAC1/INF2/SLC35F6/SREBF2/PISD/HSPA1A 9 GO:0001660 fever generation 1/1115 11/18722 0.491157321012573 0.719503930185321 EDNRB 1 GO:0002357 defense response to tumor cell 1/1115 11/18722 0.491157321012573 0.719503930185321 RBMS3 1 GO:0002604 regulation of dendritic cell antigen processing and presentation 1/1115 11/18722 0.491157321012573 0.719503930185321 CD74 1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 1/1115 11/18722 0.491157321012573 0.719503930185321 CD46 1 GO:0003157 endocardium development 1/1115 11/18722 0.491157321012573 0.719503930185321 RBPJ 1 GO:0006054 N-acetylneuraminate metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 GNE 1 GO:0006449 regulation of translational termination 1/1115 11/18722 0.491157321012573 0.719503930185321 EIF5A 1 GO:0006527 arginine catabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 ATP2B4 1 GO:0006705 mineralocorticoid biosynthetic process 1/1115 11/18722 0.491157321012573 0.719503930185321 REST 1 GO:0006971 hypotonic response 1/1115 11/18722 0.491157321012573 0.719503930185321 TRPV4 1 GO:0007144 female meiosis I 1/1115 11/18722 0.491157321012573 0.719503930185321 MLH3 1 GO:0008611 ether lipid biosynthetic process 1/1115 11/18722 0.491157321012573 0.719503930185321 FASN 1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/1115 11/18722 0.491157321012573 0.719503930185321 ATP1A1 1 GO:0010739 positive regulation of protein kinase A signaling 1/1115 11/18722 0.491157321012573 0.719503930185321 MIF 1 GO:0010887 negative regulation of cholesterol storage 1/1115 11/18722 0.491157321012573 0.719503930185321 ABCA1 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/1115 11/18722 0.491157321012573 0.719503930185321 ANXA2 1 GO:0014010 Schwann cell proliferation 1/1115 11/18722 0.491157321012573 0.719503930185321 DICER1 1 GO:0018026 peptidyl-lysine monomethylation 1/1115 11/18722 0.491157321012573 0.719503930185321 SETD2 1 GO:0019372 lipoxygenase pathway 1/1115 11/18722 0.491157321012573 0.719503930185321 HPGD 1 GO:0030432 peristalsis 1/1115 11/18722 0.491157321012573 0.719503930185321 DLG1 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/1115 11/18722 0.491157321012573 0.719503930185321 DHX36 1 GO:0032276 regulation of gonadotropin secretion 1/1115 11/18722 0.491157321012573 0.719503930185321 GJA1 1 GO:0032308 positive regulation of prostaglandin secretion 1/1115 11/18722 0.491157321012573 0.719503930185321 P2RX4 1 GO:0032341 aldosterone metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 REST 1 GO:0032377 regulation of intracellular lipid transport 1/1115 11/18722 0.491157321012573 0.719503930185321 ANXA2 1 GO:0032610 interleukin-1 alpha production 1/1115 11/18722 0.491157321012573 0.719503930185321 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/1115 11/18722 0.491157321012573 0.719503930185321 ISL1 1 GO:0033083 regulation of immature T cell proliferation 1/1115 11/18722 0.491157321012573 0.719503930185321 ERBB2 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/1115 11/18722 0.491157321012573 0.719503930185321 SKP2 1 GO:0033234 negative regulation of protein sumoylation 1/1115 11/18722 0.491157321012573 0.719503930185321 CTNNB1 1 GO:0033625 positive regulation of integrin activation 1/1115 11/18722 0.491157321012573 0.719503930185321 FERMT1 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/1115 11/18722 0.491157321012573 0.719503930185321 WNK1 1 GO:0034350 regulation of glial cell apoptotic process 1/1115 11/18722 0.491157321012573 0.719503930185321 PRKCI 1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1/1115 11/18722 0.491157321012573 0.719503930185321 TTC37 1 GO:0034454 microtubule anchoring at centrosome 1/1115 11/18722 0.491157321012573 0.719503930185321 PCM1 1 GO:0034650 cortisol metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 REST 1 GO:0034770 histone H4-K20 methylation 1/1115 11/18722 0.491157321012573 0.719503930185321 NSD1 1 GO:0034776 response to histamine 1/1115 11/18722 0.491157321012573 0.719503930185321 AOC1 1 GO:0035246 peptidyl-arginine N-methylation 1/1115 11/18722 0.491157321012573 0.719503930185321 PRMT9 1 GO:0035404 histone-serine phosphorylation 1/1115 11/18722 0.491157321012573 0.719503930185321 RPS6KA5 1 GO:0035457 cellular response to interferon-alpha 1/1115 11/18722 0.491157321012573 0.719503930185321 TPR 1 GO:0035865 cellular response to potassium ion 1/1115 11/18722 0.491157321012573 0.719503930185321 SOD1 1 GO:0039530 MDA-5 signaling pathway 1/1115 11/18722 0.491157321012573 0.719503930185321 ANKRD17 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/1115 11/18722 0.491157321012573 0.719503930185321 CHD6 1 GO:0045161 neuronal ion channel clustering 1/1115 11/18722 0.491157321012573 0.719503930185321 NRCAM 1 GO:0045628 regulation of T-helper 2 cell differentiation 1/1115 11/18722 0.491157321012573 0.719503930185321 ANXA1 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/1115 11/18722 0.491157321012573 0.719503930185321 SCIN 1 GO:0046349 amino sugar biosynthetic process 1/1115 11/18722 0.491157321012573 0.719503930185321 GNE 1 GO:0046501 protoporphyrinogen IX metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 IREB2 1 GO:0046504 glycerol ether biosynthetic process 1/1115 11/18722 0.491157321012573 0.719503930185321 FASN 1 GO:0046710 GDP metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 DLG1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/1115 11/18722 0.491157321012573 0.719503930185321 PPP1R9A 1 GO:0048635 negative regulation of muscle organ development 1/1115 11/18722 0.491157321012573 0.719503930185321 YBX3 1 GO:0048853 forebrain morphogenesis 1/1115 11/18722 0.491157321012573 0.719503930185321 NF1 1 GO:0051610 serotonin uptake 1/1115 11/18722 0.491157321012573 0.719503930185321 SLC6A4 1 GO:0052646 alditol phosphate metabolic process 1/1115 11/18722 0.491157321012573 0.719503930185321 GPD1L 1 GO:0060174 limb bud formation 1/1115 11/18722 0.491157321012573 0.719503930185321 FGFR2 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/1115 11/18722 0.491157321012573 0.719503930185321 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/1115 11/18722 0.491157321012573 0.719503930185321 GLI3 1 GO:0060746 parental behavior 1/1115 11/18722 0.491157321012573 0.719503930185321 ZFX 1 GO:0060900 embryonic camera-type eye formation 1/1115 11/18722 0.491157321012573 0.719503930185321 PHACTR4 1 GO:0061635 regulation of protein complex stability 1/1115 11/18722 0.491157321012573 0.719503930185321 TAPBP 1 GO:0070203 regulation of establishment of protein localization to telomere 1/1115 11/18722 0.491157321012573 0.719503930185321 CCT3 1 GO:0070327 thyroid hormone transport 1/1115 11/18722 0.491157321012573 0.719503930185321 SLC16A2 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/1115 11/18722 0.491157321012573 0.719503930185321 WNK1 1 GO:0070601 centromeric sister chromatid cohesion 1/1115 11/18722 0.491157321012573 0.719503930185321 CTNNB1 1 GO:0070933 histone H4 deacetylation 1/1115 11/18722 0.491157321012573 0.719503930185321 REST 1 GO:0072173 metanephric tubule morphogenesis 1/1115 11/18722 0.491157321012573 0.719503930185321 LGR4 1 GO:0072205 metanephric collecting duct development 1/1115 11/18722 0.491157321012573 0.719503930185321 DLG5 1 GO:0086016 AV node cell action potential 1/1115 11/18722 0.491157321012573 0.719503930185321 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/1115 11/18722 0.491157321012573 0.719503930185321 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/1115 11/18722 0.491157321012573 0.719503930185321 GJA5 1 GO:0090084 negative regulation of inclusion body assembly 1/1115 11/18722 0.491157321012573 0.719503930185321 HSPA1A 1 GO:0090160 Golgi to lysosome transport 1/1115 11/18722 0.491157321012573 0.719503930185321 CLN3 1 GO:0090219 negative regulation of lipid kinase activity 1/1115 11/18722 0.491157321012573 0.719503930185321 PIK3IP1 1 GO:0090394 negative regulation of excitatory postsynaptic potential 1/1115 11/18722 0.491157321012573 0.719503930185321 S1PR2 1 GO:0097048 dendritic cell apoptotic process 1/1115 11/18722 0.491157321012573 0.719503930185321 RAPGEF2 1 GO:0097384 cellular lipid biosynthetic process 1/1115 11/18722 0.491157321012573 0.719503930185321 FASN 1 GO:0099022 vesicle tethering 1/1115 11/18722 0.491157321012573 0.719503930185321 TRIP11 1 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/1115 11/18722 0.491157321012573 0.719503930185321 ATP2B4 1 GO:0140042 lipid droplet formation 1/1115 11/18722 0.491157321012573 0.719503930185321 CDS1 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/1115 11/18722 0.491157321012573 0.719503930185321 ATRX 1 GO:1900426 positive regulation of defense response to bacterium 1/1115 11/18722 0.491157321012573 0.719503930185321 GRN 1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 1/1115 11/18722 0.491157321012573 0.719503930185321 N4BP2L2 1 GO:1901862 negative regulation of muscle tissue development 1/1115 11/18722 0.491157321012573 0.719503930185321 YBX3 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/1115 11/18722 0.491157321012573 0.719503930185321 N4BP2L2 1 GO:1902065 response to L-glutamate 1/1115 11/18722 0.491157321012573 0.719503930185321 UFL1 1 GO:1902188 positive regulation of viral release from host cell 1/1115 11/18722 0.491157321012573 0.719503930185321 DDB1 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/1115 11/18722 0.491157321012573 0.719503930185321 BMP7 1 GO:1903299 regulation of hexokinase activity 1/1115 11/18722 0.491157321012573 0.719503930185321 RANBP2 1 GO:1904181 positive regulation of membrane depolarization 1/1115 11/18722 0.491157321012573 0.719503930185321 ANK3 1 GO:1904729 regulation of intestinal lipid absorption 1/1115 11/18722 0.491157321012573 0.719503930185321 LPCAT3 1 GO:1904869 regulation of protein localization to Cajal body 1/1115 11/18722 0.491157321012573 0.719503930185321 CCT3 1 GO:1904871 positive regulation of protein localization to Cajal body 1/1115 11/18722 0.491157321012573 0.719503930185321 CCT3 1 GO:1905050 positive regulation of metallopeptidase activity 1/1115 11/18722 0.491157321012573 0.719503930185321 CLDN4 1 GO:1905150 regulation of voltage-gated sodium channel activity 1/1115 11/18722 0.491157321012573 0.719503930185321 KIF5B 1 GO:1905522 negative regulation of macrophage migration 1/1115 11/18722 0.491157321012573 0.719503930185321 MIF 1 GO:2000320 negative regulation of T-helper 17 cell differentiation 1/1115 11/18722 0.491157321012573 0.719503930185321 RC3H1 1 GO:2000392 regulation of lamellipodium morphogenesis 1/1115 11/18722 0.491157321012573 0.719503930185321 KANK1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/1115 11/18722 0.491157321012573 0.719503930185321 PKIB 1 GO:2000668 regulation of dendritic cell apoptotic process 1/1115 11/18722 0.491157321012573 0.719503930185321 RAPGEF2 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/1115 11/18722 0.491157321012573 0.719503930185321 BMP7 1 GO:0051702 biological process involved in interaction with symbiont 6/1115 94/18722 0.491189214896414 0.719503930185321 GAPDH/CFL1/DDB1/FN1/STOM/REST 6 GO:0002792 negative regulation of peptide secretion 3/1115 44/18722 0.491618343756518 0.719503930185321 CD74/PPP3CA/REST 3 GO:0006775 fat-soluble vitamin metabolic process 3/1115 44/18722 0.491618343756518 0.719503930185321 LRP2/LGMN/TTPA 3 GO:0021517 ventral spinal cord development 3/1115 44/18722 0.491618343756518 0.719503930185321 VLDLR/GLI3/ISL1 3 GO:0032007 negative regulation of TOR signaling 3/1115 44/18722 0.491618343756518 0.719503930185321 TMEM127/ITFG2/ATM 3 GO:0044058 regulation of digestive system process 3/1115 44/18722 0.491618343756518 0.719503930185321 SLC22A5/WNK1/LPCAT3 3 GO:0046006 regulation of activated T cell proliferation 3/1115 44/18722 0.491618343756518 0.719503930185321 RPS3/HMGB1/RC3H1 3 GO:0150076 neuroinflammatory response 3/1115 44/18722 0.491618343756518 0.719503930185321 ITGB1/GRN/CTSC 3 GO:0050863 regulation of T cell activation 20/1115 329/18722 0.495421025068466 0.724870609164302 CD46/IL6ST/ANXA1/DPP4/CD74/RPS3/DOCK8/DLG5/DLG1/CD47/TFRC/GLI3/HMGB1/CAV1/CLPTM1/RC3H1/ERBB2/CTNNB1/RHOA/SOD1 20 GO:0043030 regulation of macrophage activation 4/1115 61/18722 0.496060787461647 0.725409078131398 GRN/MIF/CTSC/CD74 4 GO:0043954 cellular component maintenance 4/1115 61/18722 0.496060787461647 0.725409078131398 IGF1R/DLG1/MTSS1/INSR 4 GO:0009064 glutamine family amino acid metabolic process 5/1115 78/18722 0.499169652033818 0.729355985826096 ATP2B4/CLN3/ALDH18A1/ALDH4A1/RIMKLB 5 GO:0035050 embryonic heart tube development 5/1115 78/18722 0.499169652033818 0.729355985826096 FOLR1/MIB1/AHI1/PKD2/CTNNB1 5 GO:0070373 negative regulation of ERK1 and ERK2 cascade 5/1115 78/18722 0.499169652033818 0.729355985826096 SEMA6A/FBLN1/DLG1/GSTP1/EIF3A 5 GO:0002532 production of molecular mediator involved in inflammatory response 6/1115 95/18722 0.501584296051601 0.732054475604005 GRN/PLD3/ADCY7/CHID1/MAPK14/APPL1 6 GO:0000423 mitophagy 2/1115 28/18722 0.503210325054635 0.732054475604005 VPS13C/VDAC1 2 GO:0003156 regulation of animal organ formation 2/1115 28/18722 0.503210325054635 0.732054475604005 BMP7/CTNNB1 2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 2/1115 28/18722 0.503210325054635 0.732054475604005 YME1L1/ZYG11B 2 GO:0006829 zinc ion transport 2/1115 28/18722 0.503210325054635 0.732054475604005 SLC39A10/SLC30A7 2 GO:0009065 glutamine family amino acid catabolic process 2/1115 28/18722 0.503210325054635 0.732054475604005 ATP2B4/ALDH4A1 2 GO:0010460 positive regulation of heart rate 2/1115 28/18722 0.503210325054635 0.732054475604005 ADRB1/ATP2A2 2 GO:0010575 positive regulation of vascular endothelial growth factor production 2/1115 28/18722 0.503210325054635 0.732054475604005 IL6ST/ISL1 2 GO:0010884 positive regulation of lipid storage 2/1115 28/18722 0.503210325054635 0.732054475604005 PLIN2/SREBF2 2 GO:0031342 negative regulation of cell killing 2/1115 28/18722 0.503210325054635 0.732054475604005 HSP90AB1/SERPINB9 2 GO:0045686 negative regulation of glial cell differentiation 2/1115 28/18722 0.503210325054635 0.732054475604005 NF1/CTNNB1 2 GO:0060765 regulation of androgen receptor signaling pathway 2/1115 28/18722 0.503210325054635 0.732054475604005 NCOR1/FOXP1 2 GO:0070076 histone lysine demethylation 2/1115 28/18722 0.503210325054635 0.732054475604005 JMJD1C/KDM5A 2 GO:0071280 cellular response to copper ion 2/1115 28/18722 0.503210325054635 0.732054475604005 APP/AOC1 2 GO:0090659 walking behavior 2/1115 28/18722 0.503210325054635 0.732054475604005 NPC1/OXR1 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/1115 28/18722 0.503210325054635 0.732054475604005 AKAP9/GJA5 2 GO:0002526 acute inflammatory response 7/1115 112/18722 0.50357757484551 0.732189725517478 IL6ST/ASH1L/ANO6/B4GALT1/FN1/GSTP1/EDNRB 7 GO:0009141 nucleoside triphosphate metabolic process 7/1115 112/18722 0.50357757484551 0.732189725517478 ALDOA/ENO1/TMSB4X/AK3/RRM2B/RAN/RHOA 7 GO:0001505 regulation of neurotransmitter levels 13/1115 213/18722 0.504699010540354 0.733620478430424 ITGB1/SLC6A4/CALM1/ATP2A2/SYT7/SLC38A1/SLC1A3/PPP1R9A/SLC29A1/RAB3GAP1/CLN3/GCHFR/MCTP2 13 GO:0003009 skeletal muscle contraction 3/1115 45/18722 0.506796182475749 0.73375855757753 GAA/ATP2A2/DMD 3 GO:0006110 regulation of glycolytic process 3/1115 45/18722 0.506796182475749 0.73375855757753 APP/NCOR1/INSR 3 GO:0032309 icosanoid secretion 3/1115 45/18722 0.506796182475749 0.73375855757753 ANXA1/P2RX4/PLA2R1 3 GO:0035305 negative regulation of dephosphorylation 3/1115 45/18722 0.506796182475749 0.73375855757753 BOD1L1/YWHAE/ROCK1 3 GO:0046189 phenol-containing compound biosynthetic process 3/1115 45/18722 0.506796182475749 0.73375855757753 OPN3/APPL1/RAPGEF2 3 GO:0051985 negative regulation of chromosome segregation 3/1115 45/18722 0.506796182475749 0.73375855757753 TPR/ZNF207/ATM 3 GO:0085029 extracellular matrix assembly 3/1115 45/18722 0.506796182475749 0.73375855757753 DAG1/LAMB1/LTBP3 3 GO:1901985 positive regulation of protein acetylation 3/1115 45/18722 0.506796182475749 0.73375855757753 RPS6KA5/TAOK1/ISL1 3 GO:1905819 negative regulation of chromosome separation 3/1115 45/18722 0.506796182475749 0.73375855757753 TPR/ZNF207/ATM 3 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 4/1115 62/18722 0.508941809767996 0.73375855757753 TPR/ZNF207/ATM/UBE2C 4 GO:0031124 mRNA 3'-end processing 4/1115 62/18722 0.508941809767996 0.73375855757753 APP/ZFP36L1/AHCYL1/DHX36 4 GO:0072521 purine-containing compound metabolic process 25/1115 416/18722 0.511221678164652 0.73375855757753 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RAN/ACSL3/INSR/PDE10A/PDE7A/ELOVL1/FASN/GPAT4/RHOA 25 GO:0002718 regulation of cytokine production involved in immune response 6/1115 96/18722 0.511903604349158 0.73375855757753 CD74/FZD5/DHX36/SEMA7A/TLR3/MAVS 6 GO:0006637 acyl-CoA metabolic process 6/1115 96/18722 0.511903604349158 0.73375855757753 ACSS1/TECR/ACSL3/ELOVL1/FASN/GPAT4 6 GO:0035383 thioester metabolic process 6/1115 96/18722 0.511903604349158 0.73375855757753 ACSS1/TECR/ACSL3/ELOVL1/FASN/GPAT4 6 GO:0042632 cholesterol homeostasis 6/1115 96/18722 0.511903604349158 0.73375855757753 LRP5/ABCA1/NPC1/TSKU/CAV1/SREBF2 6 GO:1901655 cellular response to ketone 6/1115 96/18722 0.511903604349158 0.73375855757753 EGFR/ATP2B1/SERPINF1/NR3C1/XRN1/CFLAR 6 GO:0007098 centrosome cycle 8/1115 130/18722 0.514147249027487 0.73375855757753 NPM1/PCM1/SLC16A1/PPP1R12A/CEP152/RANBP1/PKD2/CTNNB1 8 GO:0097696 receptor signaling pathway via STAT 11/1115 181/18722 0.516902566240276 0.73375855757753 IL6ST/CSH1/PRLR/IL10RB/PARP14/PIAS1/CAV1/SUZ12/PKD2/ISL1/OCIAD2 11 GO:0031669 cellular response to nutrient levels 13/1115 215/18722 0.518498782802363 0.73375855757753 ATP2B1/HNRNPA1/SLC2A1/SLC38A2/FOLR1/LAMP2/HSPA5/AOC1/KLF10/CPEB4/BMPR2/SREBF2/ITFG2 13 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/1115 12/18722 0.521479569266059 0.73375855757753 NAV2 1 GO:0002328 pro-B cell differentiation 1/1115 12/18722 0.521479569266059 0.73375855757753 PRKDC 1 GO:0006285 base-excision repair, AP site formation 1/1115 12/18722 0.521479569266059 0.73375855757753 TDG 1 GO:0006563 L-serine metabolic process 1/1115 12/18722 0.521479569266059 0.73375855757753 SERINC3 1 GO:0007320 insemination 1/1115 12/18722 0.521479569266059 0.73375855757753 SLC6A4 1 GO:0007501 mesodermal cell fate specification 1/1115 12/18722 0.521479569266059 0.73375855757753 BMPR1A 1 GO:0007614 short-term memory 1/1115 12/18722 0.521479569266059 0.73375855757753 SERPINF1 1 GO:0008212 mineralocorticoid metabolic process 1/1115 12/18722 0.521479569266059 0.73375855757753 REST 1 GO:0009086 methionine biosynthetic process 1/1115 12/18722 0.521479569266059 0.73375855757753 MTR 1 GO:0010623 programmed cell death involved in cell development 1/1115 12/18722 0.521479569266059 0.73375855757753 PRKDC 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/1115 12/18722 0.521479569266059 0.73375855757753 LRP1 1 GO:0010826 negative regulation of centrosome duplication 1/1115 12/18722 0.521479569266059 0.73375855757753 NPM1 1 GO:0014889 muscle atrophy 1/1115 12/18722 0.521479569266059 0.73375855757753 CFLAR 1 GO:0016188 synaptic vesicle maturation 1/1115 12/18722 0.521479569266059 0.73375855757753 CLCN3 1 GO:0016554 cytidine to uridine editing 1/1115 12/18722 0.521479569266059 0.73375855757753 RBM47 1 GO:0021781 glial cell fate commitment 1/1115 12/18722 0.521479569266059 0.73375855757753 CTNNB1 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/1115 12/18722 0.521479569266059 0.73375855757753 SLC6A4 1 GO:0030238 male sex determination 1/1115 12/18722 0.521479569266059 0.73375855757753 SF1 1 GO:0031223 auditory behavior 1/1115 12/18722 0.521479569266059 0.73375855757753 SLC1A3 1 GO:0031953 negative regulation of protein autophosphorylation 1/1115 12/18722 0.521479569266059 0.73375855757753 CAV1 1 GO:0032306 regulation of prostaglandin secretion 1/1115 12/18722 0.521479569266059 0.73375855757753 P2RX4 1 GO:0033079 immature T cell proliferation 1/1115 12/18722 0.521479569266059 0.73375855757753 ERBB2 1 GO:0033127 regulation of histone phosphorylation 1/1115 12/18722 0.521479569266059 0.73375855757753 RPS6KA5 1 GO:0033235 positive regulation of protein sumoylation 1/1115 12/18722 0.521479569266059 0.73375855757753 PIAS1 1 GO:0033629 negative regulation of cell adhesion mediated by integrin 1/1115 12/18722 0.521479569266059 0.73375855757753 WNK1 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/1115 12/18722 0.521479569266059 0.73375855757753 HMGB1 1 GO:0038203 TORC2 signaling 1/1115 12/18722 0.521479569266059 0.73375855757753 RICTOR 1 GO:0043129 surfactant homeostasis 1/1115 12/18722 0.521479569266059 0.73375855757753 ITGB6 1 GO:0043248 proteasome assembly 1/1115 12/18722 0.521479569266059 0.73375855757753 POMP 1 GO:0043380 regulation of memory T cell differentiation 1/1115 12/18722 0.521479569266059 0.73375855757753 CD46 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/1115 12/18722 0.521479569266059 0.73375855757753 PHIP 1 GO:0044650 adhesion of symbiont to host cell 1/1115 12/18722 0.521479569266059 0.73375855757753 HSP90AB1 1 GO:0045916 negative regulation of complement activation 1/1115 12/18722 0.521479569266059 0.73375855757753 CD46 1 GO:0046051 UTP metabolic process 1/1115 12/18722 0.521479569266059 0.73375855757753 AK3 1 GO:0046541 saliva secretion 1/1115 12/18722 0.521479569266059 0.73375855757753 KCNN4 1 GO:0046606 negative regulation of centrosome cycle 1/1115 12/18722 0.521479569266059 0.73375855757753 NPM1 1 GO:0048934 peripheral nervous system neuron differentiation 1/1115 12/18722 0.521479569266059 0.73375855757753 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/1115 12/18722 0.521479569266059 0.73375855757753 ISL1 1 GO:0051013 microtubule severing 1/1115 12/18722 0.521479569266059 0.73375855757753 FIGN 1 GO:0051340 regulation of ligase activity 1/1115 12/18722 0.521479569266059 0.73375855757753 TMSB4X 1 GO:0051639 actin filament network formation 1/1115 12/18722 0.521479569266059 0.73375855757753 COBL 1 GO:0060221 retinal rod cell differentiation 1/1115 12/18722 0.521479569266059 0.73375855757753 NAGLU 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/1115 12/18722 0.521479569266059 0.73375855757753 LRP1 1 GO:0060788 ectodermal placode formation 1/1115 12/18722 0.521479569266059 0.73375855757753 CTNNB1 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/1115 12/18722 0.521479569266059 0.73375855757753 GLI3 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/1115 12/18722 0.521479569266059 0.73375855757753 ENO1 1 GO:0070170 regulation of tooth mineralization 1/1115 12/18722 0.521479569266059 0.73375855757753 SLC4A2 1 GO:0070202 regulation of establishment of protein localization to chromosome 1/1115 12/18722 0.521479569266059 0.73375855757753 CCT3 1 GO:0070213 protein auto-ADP-ribosylation 1/1115 12/18722 0.521479569266059 0.73375855757753 TNKS2 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/1115 12/18722 0.521479569266059 0.73375855757753 WNK1 1 GO:0071107 response to parathyroid hormone 1/1115 12/18722 0.521479569266059 0.73375855757753 GJA1 1 GO:0071468 cellular response to acidic pH 1/1115 12/18722 0.521479569266059 0.73375855757753 SLC9A1 1 GO:0071697 ectodermal placode morphogenesis 1/1115 12/18722 0.521479569266059 0.73375855757753 CTNNB1 1 GO:0072182 regulation of nephron tubule epithelial cell differentiation 1/1115 12/18722 0.521479569266059 0.73375855757753 CTNNB1 1 GO:0072683 T cell extravasation 1/1115 12/18722 0.521479569266059 0.73375855757753 F11R 1 GO:0086067 AV node cell to bundle of His cell communication 1/1115 12/18722 0.521479569266059 0.73375855757753 GJA5 1 GO:0090331 negative regulation of platelet aggregation 1/1115 12/18722 0.521479569266059 0.73375855757753 C1QTNF1 1 GO:0097152 mesenchymal cell apoptotic process 1/1115 12/18722 0.521479569266059 0.73375855757753 BMP7 1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/1115 12/18722 0.521479569266059 0.73375855757753 HSPA1A 1 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/1115 12/18722 0.521479569266059 0.73375855757753 MIA3 1 GO:0140289 protein mono-ADP-ribosylation 1/1115 12/18722 0.521479569266059 0.73375855757753 PARP14 1 GO:0150065 regulation of deacetylase activity 1/1115 12/18722 0.521479569266059 0.73375855757753 KDM5A 1 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 1/1115 12/18722 0.521479569266059 0.73375855757753 MET 1 GO:1901503 ether biosynthetic process 1/1115 12/18722 0.521479569266059 0.73375855757753 FASN 1 GO:1902563 regulation of neutrophil activation 1/1115 12/18722 0.521479569266059 0.73375855757753 GRN 1 GO:1903405 protein localization to nuclear body 1/1115 12/18722 0.521479569266059 0.73375855757753 CCT3 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/1115 12/18722 0.521479569266059 0.73375855757753 VDAC1 1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/1115 12/18722 0.521479569266059 0.73375855757753 EGFR 1 GO:1904748 regulation of apoptotic process involved in development 1/1115 12/18722 0.521479569266059 0.73375855757753 BMP7 1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 1/1115 12/18722 0.521479569266059 0.73375855757753 CCT3 1 GO:1904867 protein localization to Cajal body 1/1115 12/18722 0.521479569266059 0.73375855757753 CCT3 1 GO:1905245 regulation of aspartic-type peptidase activity 1/1115 12/18722 0.521479569266059 0.73375855757753 GRN 1 GO:2000035 regulation of stem cell division 1/1115 12/18722 0.521479569266059 0.73375855757753 NCOA3 1 GO:2000105 positive regulation of DNA-dependent DNA replication 1/1115 12/18722 0.521479569266059 0.73375855757753 ATRX 1 GO:2000303 regulation of ceramide biosynthetic process 1/1115 12/18722 0.521479569266059 0.73375855757753 ORMDL1 1 GO:2000317 negative regulation of T-helper 17 type immune response 1/1115 12/18722 0.521479569266059 0.73375855757753 RC3H1 1 GO:2001214 positive regulation of vasculogenesis 1/1115 12/18722 0.521479569266059 0.73375855757753 RAPGEF2 1 GO:0001947 heart looping 4/1115 63/18722 0.521671878389497 0.73375855757753 FOLR1/MIB1/AHI1/PKD2 4 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 4/1115 63/18722 0.521671878389497 0.73375855757753 GRINA/SERINC3/HSPA1A/WFS1 4 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 4/1115 63/18722 0.521671878389497 0.73375855757753 TPR/ZNF207/ATM/UBE2C 4 GO:2000242 negative regulation of reproductive process 4/1115 63/18722 0.521671878389497 0.73375855757753 GJA1/SERPINF1/BMP7/PRDX4 4 GO:2000756 regulation of peptidyl-lysine acetylation 4/1115 63/18722 0.521671878389497 0.73375855757753 RPS6KA5/ZNF451/KMT2A/ISL1 4 GO:0007019 microtubule depolymerization 3/1115 46/18722 0.52173427094627 0.73375855757753 TAOK1/TRPV4/CAMSAP2 3 GO:0033047 regulation of mitotic sister chromatid segregation 3/1115 46/18722 0.52173427094627 0.73375855757753 TPR/ZNF207/ATM 3 GO:0043462 regulation of ATPase activity 3/1115 46/18722 0.52173427094627 0.73375855757753 PFN1/TMEM64/TOR1AIP2 3 GO:0071827 plasma lipoprotein particle organization 3/1115 46/18722 0.52173427094627 0.73375855757753 ABCA1/ACSL3/LPCAT3 3 GO:0010596 negative regulation of endothelial cell migration 6/1115 97/18722 0.522141732459716 0.73375855757753 ATP2B4/SERPINF1/NR2F2/PTPRM/HMGB1/RHOA 6 GO:0055092 sterol homeostasis 6/1115 97/18722 0.522141732459716 0.73375855757753 LRP5/ABCA1/NPC1/TSKU/CAV1/SREBF2 6 GO:0002360 T cell lineage commitment 2/1115 29/18722 0.522149828577396 0.73375855757753 PRKDC/RHOA 2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/1115 29/18722 0.522149828577396 0.73375855757753 FURIN/MAPK14 2 GO:0003209 cardiac atrium morphogenesis 2/1115 29/18722 0.522149828577396 0.73375855757753 BMPR2/ISL1 2 GO:0010390 histone monoubiquitination 2/1115 29/18722 0.522149828577396 0.73375855757753 DDB1/SKP1 2 GO:0010458 exit from mitosis 2/1115 29/18722 0.522149828577396 0.73375855757753 RPL24/UBE2C 2 GO:0015701 bicarbonate transport 2/1115 29/18722 0.522149828577396 0.73375855757753 SLC26A2/SLC4A2 2 GO:0021522 spinal cord motor neuron differentiation 2/1115 29/18722 0.522149828577396 0.73375855757753 GLI3/ISL1 2 GO:0031069 hair follicle morphogenesis 2/1115 29/18722 0.522149828577396 0.73375855757753 FGFR2/CTNNB1 2 GO:0033028 myeloid cell apoptotic process 2/1115 29/18722 0.522149828577396 0.73375855757753 ANXA1/ADAM17 2 GO:0035066 positive regulation of histone acetylation 2/1115 29/18722 0.522149828577396 0.73375855757753 RPS6KA5/ISL1 2 GO:0040018 positive regulation of multicellular organism growth 2/1115 29/18722 0.522149828577396 0.73375855757753 NIPBL/CELF1 2 GO:0051654 establishment of mitochondrion localization 2/1115 29/18722 0.522149828577396 0.73375855757753 LRPPRC/TRAK2 2 GO:0090114 COPII-coated vesicle budding 2/1115 29/18722 0.522149828577396 0.73375855757753 SEC31A/MIA3 2 GO:0095500 acetylcholine receptor signaling pathway 2/1115 29/18722 0.522149828577396 0.73375855757753 GNAQ/LY6E 2 GO:0098868 bone growth 2/1115 29/18722 0.522149828577396 0.73375855757753 TSKU/FGFR2 2 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 2/1115 29/18722 0.522149828577396 0.73375855757753 ANK3/CAV1 2 GO:1902430 negative regulation of amyloid-beta formation 2/1115 29/18722 0.522149828577396 0.73375855757753 RTN4/ROCK1 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/1115 29/18722 0.522149828577396 0.73375855757753 PRKDC/RIF1 2 GO:0002286 T cell activation involved in immune response 7/1115 114/18722 0.522522951097541 0.73375855757753 CD46/ANXA1/RPS6/CD74/FOXP1/HMGB1/RC3H1 7 GO:0019751 polyol metabolic process 7/1115 114/18722 0.522522951097541 0.73375855757753 ASAH1/PLPP3/SLC5A3/SGPP1/TPI1/SPTLC3/ISYNA1 7 GO:1904892 regulation of receptor signaling pathway via STAT 7/1115 114/18722 0.522522951097541 0.73375855757753 CSH1/PRLR/IL10RB/PARP14/CAV1/SUZ12/OCIAD2 7 GO:0050870 positive regulation of T cell activation 13/1115 216/18722 0.525358758218265 0.737546781521777 CD46/IL6ST/ANXA1/DPP4/CD74/RPS3/DOCK8/CD47/TFRC/GLI3/HMGB1/CAV1/RHOA 13 GO:0032102 negative regulation of response to external stimulus 25/1115 420/18722 0.531036748698187 0.745322082360573 GRN/SEMA6D/NRP1/SEMA6A/ASH1L/MIF/DPP4/SEMA3F/GJA1/TFPI/SERPINF1/FURIN/GSTP1/PCBP2/RYK/SEMA4B/PARP14/C1QTNF1/SEMA7A/MAPK14/LPCAT3/ANXA2/ISL1/SERPINB9/SOD1 25 GO:0002367 cytokine production involved in immune response 6/1115 98/18722 0.53229353406024 0.746889665794381 CD74/FZD5/DHX36/SEMA7A/TLR3/MAVS 6 GO:0046579 positive regulation of Ras protein signal transduction 4/1115 64/18722 0.534242573838267 0.749230654510772 ADGRG1/NET1/AKAP13/F11R 4 GO:0048247 lymphocyte chemotaxis 4/1115 64/18722 0.534242573838267 0.749230654510772 PLEC/ADAM10/ADAM17/WNK1 4 GO:0032008 positive regulation of TOR signaling 3/1115 47/18722 0.536421495862091 0.751102640023001 SLC38A9/RICTOR/AKT3 3 GO:0032369 negative regulation of lipid transport 3/1115 47/18722 0.536421495862091 0.751102640023001 ITGAV/SREBF2/PLA2R1 3 GO:0043114 regulation of vascular permeability 3/1115 47/18722 0.536421495862091 0.751102640023001 PLEC/TRPV4/OCLN 3 GO:0045911 positive regulation of DNA recombination 3/1115 47/18722 0.536421495862091 0.751102640023001 RIF1/TFRC/FUS 3 GO:0050798 activated T cell proliferation 3/1115 47/18722 0.536421495862091 0.751102640023001 RPS3/HMGB1/RC3H1 3 GO:0090279 regulation of calcium ion import 3/1115 47/18722 0.536421495862091 0.751102640023001 VDAC1/PKD2/CTNNB1 3 GO:0055088 lipid homeostasis 10/1115 167/18722 0.539450772504379 0.751783701475361 LRP5/ABCA1/RTN4/ORMDL1/NPC1/TSKU/CAV1/SREBF2/ACOX1/ITGB6 10 GO:0046887 positive regulation of hormone secretion 8/1115 133/18722 0.540388188396632 0.751783701475361 EGFR/LRP1/DYNLL1/GJA1/TCF7L2/KIF5B/C1QTNF1/ISL1 8 GO:0000132 establishment of mitotic spindle orientation 2/1115 30/18722 0.540597791691881 0.751783701475361 ITGB1/GJA1 2 GO:0006099 tricarboxylic acid cycle 2/1115 30/18722 0.540597791691881 0.751783701475361 IREB2/IDH1 2 GO:0007176 regulation of epidermal growth factor-activated receptor activity 2/1115 30/18722 0.540597791691881 0.751783701475361 APP/ADAM17 2 GO:0007202 activation of phospholipase C activity 2/1115 30/18722 0.540597791691881 0.751783701475361 EGFR/GNAQ 2 GO:0010453 regulation of cell fate commitment 2/1115 30/18722 0.540597791691881 0.751783701475361 ESRP1/BMPR1A 2 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/1115 30/18722 0.540597791691881 0.751783701475361 CALM1/DMD 2 GO:0044030 regulation of DNA methylation 2/1115 30/18722 0.540597791691881 0.751783701475361 MPHOSPH8/KMT2A 2 GO:0044788 modulation by host of viral process 2/1115 30/18722 0.540597791691881 0.751783701475361 CFL1/STOM 2 GO:0048799 animal organ maturation 2/1115 30/18722 0.540597791691881 0.751783701475361 PLXNB1/RHOA 2 GO:0051968 positive regulation of synaptic transmission, glutamatergic 2/1115 30/18722 0.540597791691881 0.751783701475361 EGFR/RAB3GAP1 2 GO:0070168 negative regulation of biomineral tissue development 2/1115 30/18722 0.540597791691881 0.751783701475361 LTBP3/ROCK1 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/1115 30/18722 0.540597791691881 0.751783701475361 ITM2B/AGO2 2 GO:1903579 negative regulation of ATP metabolic process 2/1115 30/18722 0.540597791691881 0.751783701475361 NCOR1/RHOA 2 GO:0031123 RNA 3'-end processing 7/1115 116/18722 0.541192972559159 0.751783701475361 APP/ZFP36L1/RPS21/AHCYL1/DHX36/INTS6/INTS1 7 GO:0021510 spinal cord development 6/1115 99/18722 0.542354123525822 0.751783701475361 NF1/VLDLR/GLI3/SUZ12/PKD2/ISL1 6 GO:0060291 long-term synaptic potentiation 6/1115 99/18722 0.542354123525822 0.751783701475361 MME/LGMN/APP/PPP1R9A/NCSTN/PAIP2 6 GO:0007032 endosome organization 5/1115 82/18722 0.544057128860066 0.751783701475361 EEA1/SCARB2/CLCN3/HOOK2/TMEM127 5 GO:0072527 pyrimidine-containing compound metabolic process 5/1115 82/18722 0.544057128860066 0.751783701475361 SLC19A3/TET2/ERH/AK3/TDG 5 GO:0010965 regulation of mitotic sister chromatid separation 4/1115 65/18722 0.546646158952315 0.751783701475361 TPR/ZNF207/ATM/UBE2C 4 GO:0038034 signal transduction in absence of ligand 4/1115 65/18722 0.546646158952315 0.751783701475361 ITGAV/ERBB3/IFI6/HSPA1A 4 GO:0044784 metaphase/anaphase transition of cell cycle 4/1115 65/18722 0.546646158952315 0.751783701475361 TPR/ZNF207/ATM/UBE2C 4 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 4/1115 65/18722 0.546646158952315 0.751783701475361 ITGAV/ERBB3/IFI6/HSPA1A 4 GO:0002833 positive regulation of response to biotic stimulus 10/1115 168/18722 0.547164259136762 0.751783701475361 GRN/PRKDC/PUM2/PUM1/HMGB1/ANKRD17/MAVS/CREBBP/MR1/CADM1 10 GO:2000241 regulation of reproductive process 10/1115 168/18722 0.547164259136762 0.751783701475361 GJA1/SERPINF1/BMP7/PRDX4/B4GALT1/AGO2/EDNRB/SMURF2/CTNNB1/CDC20 10 GO:0001768 establishment of T cell polarity 1/1115 13/18722 0.549996420162283 0.751783701475361 DOCK8 1 GO:0001886 endothelial cell morphogenesis 1/1115 13/18722 0.549996420162283 0.751783701475361 MET 1 GO:0002638 negative regulation of immunoglobulin production 1/1115 13/18722 0.549996420162283 0.751783701475361 PRKDC 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/1115 13/18722 0.549996420162283 0.751783701475361 CTNNB1 1 GO:0005513 detection of calcium ion 1/1115 13/18722 0.549996420162283 0.751783701475361 CALM1 1 GO:0006000 fructose metabolic process 1/1115 13/18722 0.549996420162283 0.751783701475361 ALDOA 1 GO:0006264 mitochondrial DNA replication 1/1115 13/18722 0.549996420162283 0.751783701475361 RRM2B 1 GO:0007183 SMAD protein complex assembly 1/1115 13/18722 0.549996420162283 0.751783701475361 SMAD2 1 GO:0007567 parturition 1/1115 13/18722 0.549996420162283 0.751783701475361 HPGD 1 GO:0010635 regulation of mitochondrial fusion 1/1115 13/18722 0.549996420162283 0.751783701475361 TFRC 1 GO:0010755 regulation of plasminogen activation 1/1115 13/18722 0.549996420162283 0.751783701475361 ENO1 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/1115 13/18722 0.549996420162283 0.751783701475361 ARL6IP5 1 GO:0014745 negative regulation of muscle adaptation 1/1115 13/18722 0.549996420162283 0.751783701475361 ATP2B4 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/1115 13/18722 0.549996420162283 0.751783701475361 CFLAR 1 GO:0015791 polyol transport 1/1115 13/18722 0.549996420162283 0.751783701475361 SLC5A3 1 GO:0016078 tRNA catabolic process 1/1115 13/18722 0.549996420162283 0.751783701475361 DICER1 1 GO:0016322 neuron remodeling 1/1115 13/18722 0.549996420162283 0.751783701475361 APP 1 GO:0021514 ventral spinal cord interneuron differentiation 1/1115 13/18722 0.549996420162283 0.751783701475361 GLI3 1 GO:0030836 positive regulation of actin filament depolymerization 1/1115 13/18722 0.549996420162283 0.751783701475361 DSTN 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/1115 13/18722 0.549996420162283 0.751783701475361 KIF5B 1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1/1115 13/18722 0.549996420162283 0.751783701475361 SKP2 1 GO:0033262 regulation of nuclear cell cycle DNA replication 1/1115 13/18722 0.549996420162283 0.751783701475361 ATRX 1 GO:0033700 phospholipid efflux 1/1115 13/18722 0.549996420162283 0.751783701475361 ABCA1 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/1115 13/18722 0.549996420162283 0.751783701475361 HMGB1 1 GO:0034309 primary alcohol biosynthetic process 1/1115 13/18722 0.549996420162283 0.751783701475361 REST 1 GO:0034497 protein localization to phagophore assembly site 1/1115 13/18722 0.549996420162283 0.751783701475361 ATG9A 1 GO:0034982 mitochondrial protein processing 1/1115 13/18722 0.549996420162283 0.751783701475361 YME1L1 1 GO:0035845 photoreceptor cell outer segment organization 1/1115 13/18722 0.549996420162283 0.751783701475361 AHI1 1 GO:0036302 atrioventricular canal development 1/1115 13/18722 0.549996420162283 0.751783701475361 RBPJ 1 GO:0042308 negative regulation of protein import into nucleus 1/1115 13/18722 0.549996420162283 0.751783701475361 FERMT1 1 GO:0042538 hyperosmotic salinity response 1/1115 13/18722 0.549996420162283 0.751783701475361 TRPV4 1 GO:0043247 telomere maintenance in response to DNA damage 1/1115 13/18722 0.549996420162283 0.751783701475361 RIF1 1 GO:0043379 memory T cell differentiation 1/1115 13/18722 0.549996420162283 0.751783701475361 CD46 1 GO:0043928 exonucleolytic catabolism of deadenylated mRNA 1/1115 13/18722 0.549996420162283 0.751783701475361 DCP2 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/1115 13/18722 0.549996420162283 0.751783701475361 ADAM17 1 GO:0046415 urate metabolic process 1/1115 13/18722 0.549996420162283 0.751783701475361 SLC22A11 1 GO:0048711 positive regulation of astrocyte differentiation 1/1115 13/18722 0.549996420162283 0.751783701475361 IL6ST 1 GO:0051709 regulation of killing of cells of other organism 1/1115 13/18722 0.549996420162283 0.751783701475361 SERPINB9 1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/1115 13/18722 0.549996420162283 0.751783701475361 MAVS 1 GO:0061000 negative regulation of dendritic spine development 1/1115 13/18722 0.549996420162283 0.751783701475361 ASAP1 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/1115 13/18722 0.549996420162283 0.751783701475361 RBPJ 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/1115 13/18722 0.549996420162283 0.751783701475361 ENO1 1 GO:0061744 motor behavior 1/1115 13/18722 0.549996420162283 0.751783701475361 DPP4 1 GO:0070254 mucus secretion 1/1115 13/18722 0.549996420162283 0.751783701475361 EGFR 1 GO:0070316 regulation of G0 to G1 transition 1/1115 13/18722 0.549996420162283 0.751783701475361 FOXO4 1 GO:0070486 leukocyte aggregation 1/1115 13/18722 0.549996420162283 0.751783701475361 BMP7 1 GO:0070914 UV-damage excision repair 1/1115 13/18722 0.549996420162283 0.751783701475361 DDB1 1 GO:0071027 nuclear RNA surveillance 1/1115 13/18722 0.549996420162283 0.751783701475361 XRN1 1 GO:0071028 nuclear mRNA surveillance 1/1115 13/18722 0.549996420162283 0.751783701475361 XRN1 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/1115 13/18722 0.549996420162283 0.751783701475361 PCM1 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/1115 13/18722 0.549996420162283 0.751783701475361 ORMDL1 1 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/1115 13/18722 0.549996420162283 0.751783701475361 ATP2B4 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/1115 13/18722 0.549996420162283 0.751783701475361 IARS2 1 GO:1900452 regulation of long-term synaptic depression 1/1115 13/18722 0.549996420162283 0.751783701475361 PPP1R9A 1 GO:1901096 regulation of autophagosome maturation 1/1115 13/18722 0.549996420162283 0.751783701475361 CLN3 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/1115 13/18722 0.549996420162283 0.751783701475361 ANK3 1 GO:1902947 regulation of tau-protein kinase activity 1/1115 13/18722 0.549996420162283 0.751783701475361 HSP90AB1 1 GO:1903054 negative regulation of extracellular matrix organization 1/1115 13/18722 0.549996420162283 0.751783701475361 DPP4 1 GO:1904478 regulation of intestinal absorption 1/1115 13/18722 0.549996420162283 0.751783701475361 LPCAT3 1 GO:1904590 negative regulation of protein import 1/1115 13/18722 0.549996420162283 0.751783701475361 FERMT1 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/1115 13/18722 0.549996420162283 0.751783701475361 VPS13C 1 GO:1905038 regulation of membrane lipid metabolic process 1/1115 13/18722 0.549996420162283 0.751783701475361 ORMDL1 1 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 1/1115 13/18722 0.549996420162283 0.751783701475361 NFATC3 1 GO:2001023 regulation of response to drug 1/1115 13/18722 0.549996420162283 0.751783701475361 ADIRF 1 GO:2001198 regulation of dendritic cell differentiation 1/1115 13/18722 0.549996420162283 0.751783701475361 HMGB1 1 GO:0002702 positive regulation of production of molecular mediator of immune response 7/1115 117/18722 0.550414785699598 0.751783701475361 CD74/RIF1/TFRC/FZD5/DHX36/SEMA7A/MAVS 7 GO:0014902 myotube differentiation 7/1115 117/18722 0.550414785699598 0.751783701475361 PLD3/PLEC/MAPK14/CFLAR/MYOF/PPP3CA/ERVW-1 7 GO:0002697 regulation of immune effector process 20/1115 339/18722 0.550646688428683 0.751783701475361 CD46/GRN/ANXA1/CD74/PRKDC/RIF1/CD47/TFRC/FZD5/DHX36/HMGB1/SEMA7A/APPL1/TLR3/ANKRD17/MAVS/RC3H1/SERPINB9/MR1/CADM1 20 GO:0010569 regulation of double-strand break repair via homologous recombination 3/1115 48/18722 0.550848068958908 0.751783701475361 RIF1/SETD2/FUS 3 GO:0033628 regulation of cell adhesion mediated by integrin 3/1115 48/18722 0.550848068958908 0.751783701475361 DPP4/FERMT1/WNK1 3 GO:0045912 negative regulation of carbohydrate metabolic process 3/1115 48/18722 0.550848068958908 0.751783701475361 CLTC/NCOR1/SOGA1 3 GO:1905710 positive regulation of membrane permeability 3/1115 48/18722 0.550848068958908 0.751783701475361 SLC9A1/SLC35F6/HSPA1A 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/1115 48/18722 0.550848068958908 0.751783701475361 PDIA3/CAV1/LTBR 3 GO:0009062 fatty acid catabolic process 6/1115 100/18722 0.552318874974854 0.753213403190484 SLC27A2/CROT/ECHDC2/CPT2/ABCD3/ACOX1 6 GO:0019218 regulation of steroid metabolic process 6/1115 100/18722 0.552318874974854 0.753213403190484 ASAH1/SF1/ATP1A1/LPCAT3/REST/SOD1 6 GO:0051588 regulation of neurotransmitter transport 6/1115 100/18722 0.552318874974854 0.753213403190484 ITGB1/CALM1/ATP2A2/PPP1R9A/RAB3GAP1/MCTP2 6 GO:0009152 purine ribonucleotide biosynthetic process 10/1115 169/18722 0.554828971808101 0.756264284448423 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/ACSL3/ELOVL1 10 GO:0050672 negative regulation of lymphocyte proliferation 5/1115 83/18722 0.554980982668837 0.756264284448423 DLG5/DLG1/RC3H1/ATM/ERBB2 5 GO:0050886 endocrine process 5/1115 83/18722 0.554980982668837 0.756264284448423 MME/GJA1/ENPEP/C1QTNF1/RHOA 5 GO:0016573 histone acetylation 9/1115 152/18722 0.556035145217986 0.756359092144597 NCOA3/MORF4L2/RPS6KA5/ZNF451/JADE1/KMT2A/ISL1/CREBBP/MORF4L1 9 GO:0006650 glycerophospholipid metabolic process 18/1115 306/18722 0.55658536769396 0.756359092144597 PGAP1/SERINC1/SLC44A2/CDS1/SMG1/SERINC3/GPAA1/SLC44A1/CLN3/OSBPL8/ACSL3/PISD/LPCAT3/AGPAT1/ATM/SERINC2/GPAT4/ETNK1 18 GO:0001782 B cell homeostasis 2/1115 31/18722 0.558545544202056 0.756359092144597 CD74/RC3H1 2 GO:0002230 positive regulation of defense response to virus by host 2/1115 31/18722 0.558545544202056 0.756359092144597 TRIM44/MAVS 2 GO:0002828 regulation of type 2 immune response 2/1115 31/18722 0.558545544202056 0.756359092144597 ANXA1/CD74 2 GO:0030212 hyaluronan metabolic process 2/1115 31/18722 0.558545544202056 0.756359092144597 ITIH5/CLTC 2 GO:0031063 regulation of histone deacetylation 2/1115 31/18722 0.558545544202056 0.756359092144597 NIPBL/KDM5A 2 GO:0033238 regulation of cellular amine metabolic process 2/1115 31/18722 0.558545544202056 0.756359092144597 ATP2B4/CLN3 2 GO:0034472 snRNA 3'-end processing 2/1115 31/18722 0.558545544202056 0.756359092144597 INTS6/INTS1 2 GO:0035115 embryonic forelimb morphogenesis 2/1115 31/18722 0.558545544202056 0.756359092144597 NIPBL/CTNNB1 2 GO:0050482 arachidonic acid secretion 2/1115 31/18722 0.558545544202056 0.756359092144597 ANXA1/PLA2R1 2 GO:0051569 regulation of histone H3-K4 methylation 2/1115 31/18722 0.558545544202056 0.756359092144597 KMT2A/CTNNB1 2 GO:0055022 negative regulation of cardiac muscle tissue growth 2/1115 31/18722 0.558545544202056 0.756359092144597 GJA1/JARID2 2 GO:0055075 potassium ion homeostasis 2/1115 31/18722 0.558545544202056 0.756359092144597 ATP6V1B1/ATP1A1 2 GO:0060055 angiogenesis involved in wound healing 2/1115 31/18722 0.558545544202056 0.756359092144597 DAG1/B4GALT1 2 GO:0060795 cell fate commitment involved in formation of primary germ layer 2/1115 31/18722 0.558545544202056 0.756359092144597 BMPR1A/CTNNB1 2 GO:0061099 negative regulation of protein tyrosine kinase activity 2/1115 31/18722 0.558545544202056 0.756359092144597 CAV1/IBTK 2 GO:0061117 negative regulation of heart growth 2/1115 31/18722 0.558545544202056 0.756359092144597 GJA1/JARID2 2 GO:0070528 protein kinase C signaling 2/1115 31/18722 0.558545544202056 0.756359092144597 ADGRG1/GPD1L 2 GO:0071168 protein localization to chromatin 2/1115 31/18722 0.558545544202056 0.756359092144597 NIPBL/SETD2 2 GO:0090183 regulation of kidney development 2/1115 31/18722 0.558545544202056 0.756359092144597 LGR4/MAGED1 2 GO:0110150 negative regulation of biomineralization 2/1115 31/18722 0.558545544202056 0.756359092144597 LTBP3/ROCK1 2 GO:1903963 arachidonate transport 2/1115 31/18722 0.558545544202056 0.756359092144597 ANXA1/PLA2R1 2 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 4/1115 66/18722 0.558875560687476 0.756359092144597 PRKDC/RIF1/TFRC/HMGB1 4 GO:0006303 double-strand break repair via nonhomologous end joining 4/1115 66/18722 0.558875560687476 0.756359092144597 PRKDC/RIF1/HMGB1/ATM 4 GO:0016444 somatic cell DNA recombination 4/1115 66/18722 0.558875560687476 0.756359092144597 PRKDC/RIF1/TFRC/HMGB1 4 GO:0042093 T-helper cell differentiation 4/1115 66/18722 0.558875560687476 0.756359092144597 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0051101 regulation of DNA binding 7/1115 118/18722 0.559556194237281 0.757088322613493 CALM1/NSD1/RSF1/TMSB4X/HMGB1/ISL1/CTNNB1 7 GO:0006576 cellular biogenic amine metabolic process 6/1115 101/18722 0.562183420708926 0.760023880454377 OAZ1/SMS/AOC1/SLC44A1/LY6E/SAT1 6 GO:0042102 positive regulation of T cell proliferation 6/1115 101/18722 0.562183420708926 0.760023880454377 CD46/IL6ST/ANXA1/RPS3/TFRC/HMGB1 6 GO:1903039 positive regulation of leukocyte cell-cell adhesion 14/1115 239/18722 0.56488506625197 0.760023880454377 CD46/IL6ST/ANXA1/DPP4/CD74/NFAT5/RPS3/DOCK8/CD47/TFRC/GLI3/HMGB1/CAV1/RHOA 14 GO:0006778 porphyrin-containing compound metabolic process 3/1115 49/18722 0.565005459242147 0.760023880454377 SLC11A2/IREB2/NFE2L1 3 GO:0007602 phototransduction 3/1115 49/18722 0.565005459242147 0.760023880454377 CDS1/GNAQ/OPN3 3 GO:0008206 bile acid metabolic process 3/1115 49/18722 0.565005459242147 0.760023880454377 SLC27A2/NPC1/ABCD3 3 GO:0009395 phospholipid catabolic process 3/1115 49/18722 0.565005459242147 0.760023880454377 SMPD1/PLBD1/IDH1 3 GO:0009994 oocyte differentiation 3/1115 49/18722 0.565005459242147 0.760023880454377 LGR5/ZFX/CTNNB1 3 GO:0010823 negative regulation of mitochondrion organization 3/1115 49/18722 0.565005459242147 0.760023880454377 TFRC/SLC35F6/HSPA1A 3 GO:0021695 cerebellar cortex development 3/1115 49/18722 0.565005459242147 0.760023880454377 HSPA5/NAGLU/RERE 3 GO:0030195 negative regulation of blood coagulation 3/1115 49/18722 0.565005459242147 0.760023880454377 TFPI/C1QTNF1/ANXA2 3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 3/1115 49/18722 0.565005459242147 0.760023880454377 SKP2/FBXL5/SKP1 3 GO:0048168 regulation of neuronal synaptic plasticity 3/1115 49/18722 0.565005459242147 0.760023880454377 APP/RAB3GAP1/CLN3 3 GO:1990573 potassium ion import across plasma membrane 3/1115 49/18722 0.565005459242147 0.760023880454377 DLG1/ATP1A1/WNK1 3 GO:0002088 lens development in camera-type eye 5/1115 84/18722 0.565774460732975 0.760023880454377 DLG1/TGFBR1/FAT1/ABI2/CTNNB1 5 GO:0015844 monoamine transport 5/1115 84/18722 0.565774460732975 0.760023880454377 SLC6A4/SYT7/NISCH/LY6E/ACTB 5 GO:0032508 DNA duplex unwinding 5/1115 84/18722 0.565774460732975 0.760023880454377 ANXA1/ATRX/DHX36/CHD6/NAV2 5 GO:0032945 negative regulation of mononuclear cell proliferation 5/1115 84/18722 0.565774460732975 0.760023880454377 DLG5/DLG1/RC3H1/ATM/ERBB2 5 GO:1900542 regulation of purine nucleotide metabolic process 5/1115 84/18722 0.565774460732975 0.760023880454377 APP/NCOR1/ENO1/TMSB4X/INSR 5 GO:0042130 negative regulation of T cell proliferation 4/1115 67/18722 0.570924350750561 0.760023880454377 DLG5/DLG1/RC3H1/ERBB2 4 GO:0043967 histone H4 acetylation 4/1115 67/18722 0.570924350750561 0.760023880454377 MORF4L2/JADE1/KMT2A/MORF4L1 4 GO:0051306 mitotic sister chromatid separation 4/1115 67/18722 0.570924350750561 0.760023880454377 TPR/ZNF207/ATM/UBE2C 4 GO:0061371 determination of heart left/right asymmetry 4/1115 67/18722 0.570924350750561 0.760023880454377 FOLR1/MIB1/AHI1/PKD2 4 GO:0045833 negative regulation of lipid metabolic process 6/1115 102/18722 0.571943649088178 0.760023880454377 ORMDL1/NCOR1/ATP1A1/PIK3IP1/REST/SOD1 6 GO:0002274 myeloid leukocyte activation 13/1115 223/18722 0.57247186956058 0.760023880454377 GRN/ITGB8/APP/MIF/CTSC/CD74/ADAM10/RBPJ/FOXP1/HMGB1/ITGB6/TLR3/LTBR 13 GO:0034470 ncRNA processing 23/1115 395/18722 0.575729689506887 0.760023880454377 RPL7/RPS6/RPL5/RPS8/RPS16/DICER1/RPL7A/RPL14/PRKDC/DDX17/RPS17/RPL26/RPS21/RPS25/RPL10A/SMAD2/RPL35/AGO2/INTS6/HNRNPA2B1/RPL27/INTS1/TARBP1 23 GO:0003180 aortic valve morphogenesis 2/1115 32/18722 0.575987188848035 0.760023880454377 JAG1/ROCK1 2 GO:0006506 GPI anchor biosynthetic process 2/1115 32/18722 0.575987188848035 0.760023880454377 PGAP1/GPAA1 2 GO:0010039 response to iron ion 2/1115 32/18722 0.575987188848035 0.760023880454377 SLC11A2/CCND1 2 GO:0010743 regulation of macrophage derived foam cell differentiation 2/1115 32/18722 0.575987188848035 0.760023880454377 ITGAV/ABCA1 2 GO:0019228 neuronal action potential 2/1115 32/18722 0.575987188848035 0.760023880454377 ANK3/P2RX4 2 GO:0019934 cGMP-mediated signaling 2/1115 32/18722 0.575987188848035 0.760023880454377 EDNRB/PDE10A 2 GO:0030431 sleep 2/1115 32/18722 0.575987188848035 0.760023880454377 ADRB1/SLC29A1 2 GO:0032196 transposition 2/1115 32/18722 0.575987188848035 0.760023880454377 L1TD1/MOV10 2 GO:0042044 fluid transport 2/1115 32/18722 0.575987188848035 0.760023880454377 AHCYL1/EDNRB 2 GO:0042219 cellular modified amino acid catabolic process 2/1115 32/18722 0.575987188848035 0.760023880454377 PCYOX1/ALDH4A1 2 GO:0050850 positive regulation of calcium-mediated signaling 2/1115 32/18722 0.575987188848035 0.760023880454377 P2RX4/SLC9A1 2 GO:0061036 positive regulation of cartilage development 2/1115 32/18722 0.575987188848035 0.760023880454377 GLI3/BMPR2 2 GO:0090022 regulation of neutrophil chemotaxis 2/1115 32/18722 0.575987188848035 0.760023880454377 DPP4/CD74 2 GO:0097345 mitochondrial outer membrane permeabilization 2/1115 32/18722 0.575987188848035 0.760023880454377 SLC35F6/HSPA1A 2 GO:1901185 negative regulation of ERBB signaling pathway 2/1115 32/18722 0.575987188848035 0.760023880454377 EGFR/LGMN 2 GO:1901889 negative regulation of cell junction assembly 2/1115 32/18722 0.575987188848035 0.760023880454377 LRP1/ROCK1 2 GO:2000191 regulation of fatty acid transport 2/1115 32/18722 0.575987188848035 0.760023880454377 P2RX4/PLA2R1 2 GO:0010507 negative regulation of autophagy 5/1115 85/18722 0.576432658376692 0.760023880454377 MET/SMG1/NPC1/CTSA/TAB2 5 GO:0055013 cardiac muscle cell development 5/1115 85/18722 0.576432658376692 0.760023880454377 PLEC/AKAP13/BMPR1A/OBSL1/ISL1 5 GO:0000212 meiotic spindle organization 1/1115 14/18722 0.576815276943461 0.760023880454377 ATRX 1 GO:0001711 endodermal cell fate commitment 1/1115 14/18722 0.576815276943461 0.760023880454377 CTNNB1 1 GO:0001767 establishment of lymphocyte polarity 1/1115 14/18722 0.576815276943461 0.760023880454377 DOCK8 1 GO:0001921 positive regulation of receptor recycling 1/1115 14/18722 0.576815276943461 0.760023880454377 ANXA2 1 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1/1115 14/18722 0.576815276943461 0.760023880454377 TLR3 1 GO:0002829 negative regulation of type 2 immune response 1/1115 14/18722 0.576815276943461 0.760023880454377 ANXA1 1 GO:0003188 heart valve formation 1/1115 14/18722 0.576815276943461 0.760023880454377 GJA5 1 GO:0003214 cardiac left ventricle morphogenesis 1/1115 14/18722 0.576815276943461 0.760023880454377 RBPJ 1 GO:0007100 mitotic centrosome separation 1/1115 14/18722 0.576815276943461 0.760023880454377 RANBP1 1 GO:0007638 mechanosensory behavior 1/1115 14/18722 0.576815276943461 0.760023880454377 SLC1A3 1 GO:0009071 serine family amino acid catabolic process 1/1115 14/18722 0.576815276943461 0.760023880454377 GLDC 1 GO:0010421 hydrogen peroxide-mediated programmed cell death 1/1115 14/18722 0.576815276943461 0.760023880454377 MET 1 GO:0010457 centriole-centriole cohesion 1/1115 14/18722 0.576815276943461 0.760023880454377 CTNNB1 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/1115 14/18722 0.576815276943461 0.760023880454377 DAG1 1 GO:0018158 protein oxidation 1/1115 14/18722 0.576815276943461 0.760023880454377 PRDX3 1 GO:0019321 pentose metabolic process 1/1115 14/18722 0.576815276943461 0.760023880454377 UXS1 1 GO:0030007 cellular potassium ion homeostasis 1/1115 14/18722 0.576815276943461 0.760023880454377 ATP1A1 1 GO:0030049 muscle filament sliding 1/1115 14/18722 0.576815276943461 0.760023880454377 MYL6 1 GO:0030213 hyaluronan biosynthetic process 1/1115 14/18722 0.576815276943461 0.760023880454377 CLTC 1 GO:0031650 regulation of heat generation 1/1115 14/18722 0.576815276943461 0.760023880454377 EDNRB 1 GO:0032688 negative regulation of interferon-beta production 1/1115 14/18722 0.576815276943461 0.760023880454377 REL 1 GO:0033169 histone H3-K9 demethylation 1/1115 14/18722 0.576815276943461 0.760023880454377 JMJD1C 1 GO:0033212 iron import into cell 1/1115 14/18722 0.576815276943461 0.760023880454377 SLC11A2 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/1115 14/18722 0.576815276943461 0.760023880454377 C1QTNF1 1 GO:0035641 locomotory exploration behavior 1/1115 14/18722 0.576815276943461 0.760023880454377 DPP4 1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1/1115 14/18722 0.576815276943461 0.760023880454377 LRP1 1 GO:0035810 positive regulation of urine volume 1/1115 14/18722 0.576815276943461 0.760023880454377 EDNRB 1 GO:0035815 positive regulation of renal sodium excretion 1/1115 14/18722 0.576815276943461 0.760023880454377 EDNRB 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/1115 14/18722 0.576815276943461 0.760023880454377 LPCAT3 1 GO:0036444 calcium import into the mitochondrion 1/1115 14/18722 0.576815276943461 0.760023880454377 VDAC1 1 GO:0042415 norepinephrine metabolic process 1/1115 14/18722 0.576815276943461 0.760023880454377 LY6E 1 GO:0043249 erythrocyte maturation 1/1115 14/18722 0.576815276943461 0.760023880454377 PTBP3 1 GO:0043922 negative regulation by host of viral transcription 1/1115 14/18722 0.576815276943461 0.760023880454377 REST 1 GO:0044154 histone H3-K14 acetylation 1/1115 14/18722 0.576815276943461 0.760023880454377 KMT2A 1 GO:0044764 multi-organism cellular process 1/1115 14/18722 0.576815276943461 0.760023880454377 CAV1 1 GO:0045023 G0 to G1 transition 1/1115 14/18722 0.576815276943461 0.760023880454377 FOXO4 1 GO:0045059 positive thymic T cell selection 1/1115 14/18722 0.576815276943461 0.760023880454377 CD74 1 GO:0045472 response to ether 1/1115 14/18722 0.576815276943461 0.760023880454377 HNRNPD 1 GO:0045820 negative regulation of glycolytic process 1/1115 14/18722 0.576815276943461 0.760023880454377 NCOR1 1 GO:0045837 negative regulation of membrane potential 1/1115 14/18722 0.576815276943461 0.760023880454377 ARL6IP5 1 GO:0046348 amino sugar catabolic process 1/1115 14/18722 0.576815276943461 0.760023880454377 MGAT1 1 GO:0048875 chemical homeostasis within a tissue 1/1115 14/18722 0.576815276943461 0.760023880454377 ITGB6 1 GO:0051589 negative regulation of neurotransmitter transport 1/1115 14/18722 0.576815276943461 0.760023880454377 PPP1R9A 1 GO:0051645 Golgi localization 1/1115 14/18722 0.576815276943461 0.760023880454377 ARHGAP21 1 GO:0055057 neuroblast division 1/1115 14/18722 0.576815276943461 0.760023880454377 FGFR2 1 GO:0060081 membrane hyperpolarization 1/1115 14/18722 0.576815276943461 0.760023880454377 ATP1A1 1 GO:0060576 intestinal epithelial cell development 1/1115 14/18722 0.576815276943461 0.760023880454377 IL6ST 1 GO:0070307 lens fiber cell development 1/1115 14/18722 0.576815276943461 0.760023880454377 ABI2 1 GO:0070986 left/right axis specification 1/1115 14/18722 0.576815276943461 0.760023880454377 AHI1 1 GO:0090281 negative regulation of calcium ion import 1/1115 14/18722 0.576815276943461 0.760023880454377 VDAC1 1 GO:0090715 immunological memory formation process 1/1115 14/18722 0.576815276943461 0.760023880454377 CD46 1 GO:0097091 synaptic vesicle clustering 1/1115 14/18722 0.576815276943461 0.760023880454377 CTNNB1 1 GO:0098734 macromolecule depalmitoylation 1/1115 14/18722 0.576815276943461 0.760023880454377 LYPLA1 1 GO:1902187 negative regulation of viral release from host cell 1/1115 14/18722 0.576815276943461 0.760023880454377 TRIM13 1 GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/1115 14/18722 0.576815276943461 0.760023880454377 ERLEC1 1 GO:1904814 regulation of protein localization to chromosome, telomeric region 1/1115 14/18722 0.576815276943461 0.760023880454377 CCT3 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/1115 14/18722 0.576815276943461 0.760023880454377 VPS13C 1 GO:1905049 negative regulation of metallopeptidase activity 1/1115 14/18722 0.576815276943461 0.760023880454377 LRP1 1 GO:1905208 negative regulation of cardiocyte differentiation 1/1115 14/18722 0.576815276943461 0.760023880454377 EGFR 1 GO:1990173 protein localization to nucleoplasm 1/1115 14/18722 0.576815276943461 0.760023880454377 CCT3 1 GO:2001140 positive regulation of phospholipid transport 1/1115 14/18722 0.576815276943461 0.760023880454377 TMEM30A 1 GO:0072655 establishment of protein localization to mitochondrion 7/1115 120/18722 0.577584061661817 0.760126436863426 LMAN1/CALM1/FZD5/UBE2L3/NPEPPS/SREBF2/DNAJA1 7 GO:0002831 regulation of response to biotic stimulus 19/1115 327/18722 0.578322821578998 0.760126436863426 GRN/PRKDC/HSP90AB1/PCBP2/TRIM44/PUM2/PARP14/FOXP1/PUM1/HMGB1/APPL1/XIAP/ERAP1/ANKRD17/MAVS/CREBBP/SERPINB9/MR1/CADM1 19 GO:0019083 viral transcription 3/1115 50/18722 0.578886325582823 0.760126436863426 RSF1/REST/TRIM13 3 GO:0030490 maturation of SSU-rRNA 3/1115 50/18722 0.578886325582823 0.760126436863426 RPS8/RPS16/RPS21 3 GO:0038093 Fc receptor signaling pathway 3/1115 50/18722 0.578886325582823 0.760126436863426 CD47/VAV3/APPL1 3 GO:0043628 ncRNA 3'-end processing 3/1115 50/18722 0.578886325582823 0.760126436863426 RPS21/INTS6/INTS1 3 GO:0045058 T cell selection 3/1115 50/18722 0.578886325582823 0.760126436863426 CD74/GLI3/RHOA 3 GO:0046638 positive regulation of alpha-beta T cell differentiation 3/1115 50/18722 0.578886325582823 0.760126436863426 ANXA1/GLI3/RHOA 3 GO:0070231 T cell apoptotic process 3/1115 50/18722 0.578886325582823 0.760126436863426 RPS6/DOCK8/GLI3 3 GO:0071825 protein-lipid complex subunit organization 3/1115 50/18722 0.578886325582823 0.760126436863426 ABCA1/ACSL3/LPCAT3 3 GO:1900047 negative regulation of hemostasis 3/1115 50/18722 0.578886325582823 0.760126436863426 TFPI/C1QTNF1/ANXA2 3 GO:1901570 fatty acid derivative biosynthetic process 3/1115 50/18722 0.578886325582823 0.760126436863426 TECR/ACSL3/ELOVL1 3 GO:1902930 regulation of alcohol biosynthetic process 3/1115 50/18722 0.578886325582823 0.760126436863426 LPCAT3/REST/SOD1 3 GO:2000677 regulation of transcription regulatory region DNA binding 3/1115 50/18722 0.578886325582823 0.760126436863426 NSD1/TMSB4X/CTNNB1 3 GO:0046390 ribose phosphate biosynthetic process 11/1115 190/18722 0.582653446633408 0.76374529361754 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/ACSL3/TKT/ELOVL1 11 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 4/1115 68/18722 0.582786725266502 0.76374529361754 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0009247 glycolipid biosynthetic process 4/1115 68/18722 0.582786725266502 0.76374529361754 PGAP1/B4GALT5/GPAA1/B3GNT5 4 GO:0034394 protein localization to cell surface 4/1115 68/18722 0.582786725266502 0.76374529361754 HSP90AB1/GPD1L/PTPRK/CTNNB1 4 GO:0042267 natural killer cell mediated cytotoxicity 4/1115 68/18722 0.582786725266502 0.76374529361754 PRDX1/KIF5B/SERPINB9/CADM1 4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 4/1115 68/18722 0.582786725266502 0.76374529361754 IL6ST/CSH1/PARP14/ISL1 4 GO:0042698 ovulation cycle 4/1115 68/18722 0.582786725266502 0.76374529361754 EGFR/SERPINF1/ADAMTS1/HSPA5 4 GO:0046686 response to cadmium ion 4/1115 68/18722 0.582786725266502 0.76374529361754 EGFR/NPC1/CAT/SOD1 4 GO:0008037 cell recognition 13/1115 225/18722 0.585593191141023 0.76723485828268 COLEC12/NRP1/APP/RTN4/ALDOA/DOCK8/NRCAM/B4GALT1/DLG1/FOLR1/PALLD/CADM1/CCT3 13 GO:0002224 toll-like receptor signaling pathway 7/1115 121/18722 0.586464101164472 0.768187398458566 COLEC12/LGR4/RTN4/HMGB1/CAV1/APPL1/TLR3 7 GO:0006140 regulation of nucleotide metabolic process 5/1115 86/18722 0.58695104809171 0.768448172084757 APP/NCOR1/ENO1/TMSB4X/INSR 5 GO:0046928 regulation of neurotransmitter secretion 5/1115 86/18722 0.58695104809171 0.768448172084757 CALM1/ATP2A2/PPP1R9A/RAB3GAP1/MCTP2 5 GO:0046034 ATP metabolic process 16/1115 277/18722 0.587158358237409 0.76853112886235 GAPDH/LDHA/APP/ALDOA/COX6A1/ATP6V1B1/NCOR1/ENO1/TPI1/CHCHD2/TMSB4X/INSR/CYCS/HSPA1A/RHOA/UQCRH 16 GO:0016579 protein deubiquitination 8/1115 139/18722 0.591078608950183 0.769149650863269 USP25/USP47/USP53/USP9X/USP34/USP12/USP10/USP43 8 GO:0045621 positive regulation of lymphocyte differentiation 6/1115 104/18722 0.591135971134926 0.769149650863269 CD46/ANXA1/CD74/PRKDC/GLI3/RHOA 6 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 3/1115 51/18722 0.592484450055198 0.769149650863269 ANXA1/HMGB1/RC3H1 3 GO:0045661 regulation of myoblast differentiation 3/1115 51/18722 0.592484450055198 0.769149650863269 MBNL3/ZFP36L1/MAPK14 3 GO:0051339 regulation of lyase activity 3/1115 51/18722 0.592484450055198 0.769149650863269 AKAP9/NF1/EDNRB 3 GO:0071622 regulation of granulocyte chemotaxis 3/1115 51/18722 0.592484450055198 0.769149650863269 DPP4/CD74/TRPV4 3 GO:0006505 GPI anchor metabolic process 2/1115 33/18722 0.592919302302109 0.769149650863269 PGAP1/GPAA1 2 GO:0006536 glutamate metabolic process 2/1115 33/18722 0.592919302302109 0.769149650863269 ALDH18A1/ALDH4A1 2 GO:0006654 phosphatidic acid biosynthetic process 2/1115 33/18722 0.592919302302109 0.769149650863269 AGPAT1/GPAT4 2 GO:0010259 multicellular organism aging 2/1115 33/18722 0.592919302302109 0.769149650863269 SEC63/TFCP2L1 2 GO:0010737 protein kinase A signaling 2/1115 33/18722 0.592919302302109 0.769149650863269 MIF/RAB13 2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 2/1115 33/18722 0.592919302302109 0.769149650863269 FLT1/VAV3 2 GO:0045920 negative regulation of exocytosis 2/1115 33/18722 0.592919302302109 0.769149650863269 ANXA1/REST 2 GO:0048730 epidermis morphogenesis 2/1115 33/18722 0.592919302302109 0.769149650863269 FGFR2/CTNNB1 2 GO:0050901 leukocyte tethering or rolling 2/1115 33/18722 0.592919302302109 0.769149650863269 ITGB1/ROCK1 2 GO:0071295 cellular response to vitamin 2/1115 33/18722 0.592919302302109 0.769149650863269 ATP2B1/FOLR1 2 GO:1901099 negative regulation of signal transduction in absence of ligand 2/1115 33/18722 0.592919302302109 0.769149650863269 IFI6/HSPA1A 2 GO:1901380 negative regulation of potassium ion transmembrane transport 2/1115 33/18722 0.592919302302109 0.769149650863269 ANK3/CAV1 2 GO:1901976 regulation of cell cycle checkpoint 2/1115 33/18722 0.592919302302109 0.769149650863269 TPR/FEM1B 2 GO:1902992 negative regulation of amyloid precursor protein catabolic process 2/1115 33/18722 0.592919302302109 0.769149650863269 RTN4/ROCK1 2 GO:1903715 regulation of aerobic respiration 2/1115 33/18722 0.592919302302109 0.769149650863269 TRPV4/RHOA 2 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/1115 33/18722 0.592919302302109 0.769149650863269 IFI6/HSPA1A 2 GO:0002287 alpha-beta T cell activation involved in immune response 4/1115 69/18722 0.594457483657819 0.769149650863269 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0002293 alpha-beta T cell differentiation involved in immune response 4/1115 69/18722 0.594457483657819 0.769149650863269 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0003143 embryonic heart tube morphogenesis 4/1115 69/18722 0.594457483657819 0.769149650863269 FOLR1/MIB1/AHI1/PKD2 4 GO:0019226 transmission of nerve impulse 4/1115 69/18722 0.594457483657819 0.769149650863269 ANK3/PLEC/P2RX4/SOD1 4 GO:0051250 negative regulation of lymphocyte activation 9/1115 157/18722 0.5954721793019 0.769149650863269 ANXA1/CD74/DLG5/DLG1/GLI3/HMGB1/RC3H1/ATM/ERBB2 9 GO:0070646 protein modification by small protein removal 9/1115 157/18722 0.5954721793019 0.769149650863269 USP25/USP47/USP53/USP9X/USP34/SENP6/USP12/USP10/USP43 9 GO:0034660 ncRNA metabolic process 28/1115 485/18722 0.596265746275336 0.769149650863269 RPL7/RPS6/RPL5/RPS8/RPS16/DICER1/RPL7A/RPL14/KCNQ1OT1/PRKDC/DDX17/RPS17/RPL26/RPS21/RPS25/IARS2/RPL10A/XRN1/SMAD2/RPL35/AGO2/INTS6/HNRNPA2B1/RPL27/INTS1/TARBP1/RC3H1/SND1 28 GO:0022900 electron transport chain 10/1115 175/18722 0.599671636693214 0.769149650863269 GLDC/ASPH/COX6A1/PLEC/CHCHD2/DEGS1/ALDH4A1/DHRS3/CYCS/UQCRH 10 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/1115 15/18722 0.6020371588233 0.769149650863269 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/1115 15/18722 0.6020371588233 0.769149650863269 RPS21 1 GO:0002468 dendritic cell antigen processing and presentation 1/1115 15/18722 0.6020371588233 0.769149650863269 CD74 1 GO:0002679 respiratory burst involved in defense response 1/1115 15/18722 0.6020371588233 0.769149650863269 GRN 1 GO:0002836 positive regulation of response to tumor cell 1/1115 15/18722 0.6020371588233 0.769149650863269 MR1 1 GO:0002839 positive regulation of immune response to tumor cell 1/1115 15/18722 0.6020371588233 0.769149650863269 MR1 1 GO:0006089 lactate metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 LDHA 1 GO:0006098 pentose-phosphate shunt 1/1115 15/18722 0.6020371588233 0.769149650863269 TKT 1 GO:0006684 sphingomyelin metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 SMPD1 1 GO:0009083 branched-chain amino acid catabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 BCAT2 1 GO:0009263 deoxyribonucleotide biosynthetic process 1/1115 15/18722 0.6020371588233 0.769149650863269 RRM2B 1 GO:0010752 regulation of cGMP-mediated signaling 1/1115 15/18722 0.6020371588233 0.769149650863269 PDE10A 1 GO:0010763 positive regulation of fibroblast migration 1/1115 15/18722 0.6020371588233 0.769149650863269 ITGB1 1 GO:0014048 regulation of glutamate secretion 1/1115 15/18722 0.6020371588233 0.769149650863269 RAB3GAP1 1 GO:0014744 positive regulation of muscle adaptation 1/1115 15/18722 0.6020371588233 0.769149650863269 PPP3CA 1 GO:0014841 skeletal muscle satellite cell proliferation 1/1115 15/18722 0.6020371588233 0.769149650863269 CFLAR 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/1115 15/18722 0.6020371588233 0.769149650863269 CFLAR 1 GO:0018216 peptidyl-arginine methylation 1/1115 15/18722 0.6020371588233 0.769149650863269 PRMT9 1 GO:0018298 protein-chromophore linkage 1/1115 15/18722 0.6020371588233 0.769149650863269 OPN3 1 GO:0021542 dentate gyrus development 1/1115 15/18722 0.6020371588233 0.769149650863269 CDK6 1 GO:0023035 CD40 signaling pathway 1/1115 15/18722 0.6020371588233 0.769149650863269 ITGB1 1 GO:0032310 prostaglandin secretion 1/1115 15/18722 0.6020371588233 0.769149650863269 P2RX4 1 GO:0032328 alanine transport 1/1115 15/18722 0.6020371588233 0.769149650863269 SLC38A2 1 GO:0032354 response to follicle-stimulating hormone 1/1115 15/18722 0.6020371588233 0.769149650863269 TGFBR3 1 GO:0032486 Rap protein signal transduction 1/1115 15/18722 0.6020371588233 0.769149650863269 RAPGEF2 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/1115 15/18722 0.6020371588233 0.769149650863269 ISL1 1 GO:0032897 negative regulation of viral transcription 1/1115 15/18722 0.6020371588233 0.769149650863269 TRIM13 1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/1115 15/18722 0.6020371588233 0.769149650863269 ISL1 1 GO:0033275 actin-myosin filament sliding 1/1115 15/18722 0.6020371588233 0.769149650863269 MYL6 1 GO:0034380 high-density lipoprotein particle assembly 1/1115 15/18722 0.6020371588233 0.769149650863269 ABCA1 1 GO:0035435 phosphate ion transmembrane transport 1/1115 15/18722 0.6020371588233 0.769149650863269 ANKH 1 GO:0036124 histone H3-K9 trimethylation 1/1115 15/18722 0.6020371588233 0.769149650863269 ATRX 1 GO:0042976 activation of Janus kinase activity 1/1115 15/18722 0.6020371588233 0.769149650863269 PRLR 1 GO:0043584 nose development 1/1115 15/18722 0.6020371588233 0.769149650863269 GLI3 1 GO:0043981 histone H4-K5 acetylation 1/1115 15/18722 0.6020371588233 0.769149650863269 JADE1 1 GO:0043982 histone H4-K8 acetylation 1/1115 15/18722 0.6020371588233 0.769149650863269 JADE1 1 GO:0044406 adhesion of symbiont to host 1/1115 15/18722 0.6020371588233 0.769149650863269 HSP90AB1 1 GO:0045064 T-helper 2 cell differentiation 1/1115 15/18722 0.6020371588233 0.769149650863269 ANXA1 1 GO:0045217 cell-cell junction maintenance 1/1115 15/18722 0.6020371588233 0.769149650863269 MTSS1 1 GO:0045986 negative regulation of smooth muscle contraction 1/1115 15/18722 0.6020371588233 0.769149650863269 SOD1 1 GO:0046007 negative regulation of activated T cell proliferation 1/1115 15/18722 0.6020371588233 0.769149650863269 RC3H1 1 GO:0046459 short-chain fatty acid metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 ACSS1 1 GO:0046500 S-adenosylmethionine metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 AHCYL1 1 GO:0051290 protein heterotetramerization 1/1115 15/18722 0.6020371588233 0.769149650863269 PKD2 1 GO:0051299 centrosome separation 1/1115 15/18722 0.6020371588233 0.769149650863269 RANBP1 1 GO:0051791 medium-chain fatty acid metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 CROT 1 GO:0060026 convergent extension 1/1115 15/18722 0.6020371588233 0.769149650863269 PTK7 1 GO:0060046 regulation of acrosome reaction 1/1115 15/18722 0.6020371588233 0.769149650863269 B4GALT1 1 GO:0060253 negative regulation of glial cell proliferation 1/1115 15/18722 0.6020371588233 0.769149650863269 DICER1 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/1115 15/18722 0.6020371588233 0.769149650863269 PGAP1 1 GO:0070071 proton-transporting two-sector ATPase complex assembly 1/1115 15/18722 0.6020371588233 0.769149650863269 ATP6V1B1 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/1115 15/18722 0.6020371588233 0.769149650863269 ATP2B4 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/1115 15/18722 0.6020371588233 0.769149650863269 SLC9A1 1 GO:0071025 RNA surveillance 1/1115 15/18722 0.6020371588233 0.769149650863269 XRN1 1 GO:0072044 collecting duct development 1/1115 15/18722 0.6020371588233 0.769149650863269 DLG5 1 GO:0072224 metanephric glomerulus development 1/1115 15/18722 0.6020371588233 0.769149650863269 LGR4 1 GO:0090594 inflammatory response to wounding 1/1115 15/18722 0.6020371588233 0.769149650863269 GRN 1 GO:0097468 programmed cell death in response to reactive oxygen species 1/1115 15/18722 0.6020371588233 0.769149650863269 MET 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/1115 15/18722 0.6020371588233 0.769149650863269 ATP2B4 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/1115 15/18722 0.6020371588233 0.769149650863269 SLC9A1 1 GO:0110156 methylguanosine-cap decapping 1/1115 15/18722 0.6020371588233 0.769149650863269 DCP2 1 GO:1901741 positive regulation of myoblast fusion 1/1115 15/18722 0.6020371588233 0.769149650863269 MAPK14 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1115 15/18722 0.6020371588233 0.769149650863269 NCL 1 GO:1901841 regulation of high voltage-gated calcium channel activity 1/1115 15/18722 0.6020371588233 0.769149650863269 CALM1 1 GO:1903727 positive regulation of phospholipid metabolic process 1/1115 15/18722 0.6020371588233 0.769149650863269 ACSL3 1 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 1/1115 15/18722 0.6020371588233 0.769149650863269 CCT3 1 GO:1905168 positive regulation of double-strand break repair via homologous recombination 1/1115 15/18722 0.6020371588233 0.769149650863269 FUS 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/1115 15/18722 0.6020371588233 0.769149650863269 GPC3 1 GO:2000345 regulation of hepatocyte proliferation 1/1115 15/18722 0.6020371588233 0.769149650863269 CFLAR 1 GO:2001138 regulation of phospholipid transport 1/1115 15/18722 0.6020371588233 0.769149650863269 TMEM30A 1 GO:0018393 internal peptidyl-lysine acetylation 9/1115 158/18722 0.603156898821847 0.77039585713154 NCOA3/MORF4L2/RPS6KA5/ZNF451/JADE1/KMT2A/ISL1/CREBBP/MORF4L1 9 GO:0035176 social behavior 3/1115 52/18722 0.605794672333918 0.773394967860064 SLC6A4/PCM1/VPS13A 3 GO:2000378 negative regulation of reactive oxygen species metabolic process 3/1115 52/18722 0.605794672333918 0.773394967860064 VDAC1/CFLAR/RHOA 3 GO:0030183 B cell differentiation 8/1115 141/18722 0.607362051737784 0.775210613011721 ITGB1/ZFP36L1/PRKDC/RBPJ/ADAM17/IRF2BP2/ITFG2/ATM 8 GO:0000096 sulfur amino acid metabolic process 2/1115 34/18722 0.609340661892427 0.775696183558338 SMS/MTR 2 GO:0006356 regulation of transcription by RNA polymerase I 2/1115 34/18722 0.609340661892427 0.775696183558338 NCL/ERBB2 2 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/1115 34/18722 0.609340661892427 0.775696183558338 CALM1/DMD 2 GO:0016242 negative regulation of macroautophagy 2/1115 34/18722 0.609340661892427 0.775696183558338 SMG1/NPC1 2 GO:0031128 developmental induction 2/1115 34/18722 0.609340661892427 0.775696183558338 FZD5/CTNNB1 2 GO:0035590 purinergic nucleotide receptor signaling pathway 2/1115 34/18722 0.609340661892427 0.775696183558338 ANO6/P2RX4 2 GO:0043276 anoikis 2/1115 34/18722 0.609340661892427 0.775696183558338 ITGB1/CAV1 2 GO:0048741 skeletal muscle fiber development 2/1115 34/18722 0.609340661892427 0.775696183558338 PLEC/PPP3CA 2 GO:0050869 negative regulation of B cell activation 2/1115 34/18722 0.609340661892427 0.775696183558338 RC3H1/ATM 2 GO:0050931 pigment cell differentiation 2/1115 34/18722 0.609340661892427 0.775696183558338 GLI3/EDNRB 2 GO:2000758 positive regulation of peptidyl-lysine acetylation 2/1115 34/18722 0.609340661892427 0.775696183558338 RPS6KA5/ISL1 2 GO:0098813 nuclear chromosome segregation 16/1115 281/18722 0.61040367989202 0.776864182823241 NIPBL/ATRX/TPR/EML4/DYNC1H1/TOP2B/KPNB1/PDS5B/RAN/ZNF207/ATM/UBE2C/NUSAP1/CTNNB1/CDC20/MLH3 16 GO:1903169 regulation of calcium ion transmembrane transport 9/1115 159/18722 0.610769214297648 0.777144145647079 AHNAK/CALM1/YWHAE/SLC9A1/C4orf3/VDAC1/DMD/PKD2/VMP1 9 GO:0097553 calcium ion transmembrane import into cytosol 8/1115 142/18722 0.615377887154669 0.782782814156969 ATP2B4/CALM1/ITPR2/MCOLN3/DMD/TRPV4/PKD2/IBTK 8 GO:0002228 natural killer cell mediated immunity 4/1115 71/18722 0.61720623530914 0.782782814156969 PRDX1/KIF5B/SERPINB9/CADM1 4 GO:0050795 regulation of behavior 4/1115 71/18722 0.61720623530914 0.782782814156969 ADRB1/GJA1/ZFHX3/AHI1 4 GO:0006475 internal protein amino acid acetylation 9/1115 160/18722 0.618307253689728 0.782782814156969 NCOA3/MORF4L2/RPS6KA5/ZNF451/JADE1/KMT2A/ISL1/CREBBP/MORF4L1 9 GO:0071715 icosanoid transport 3/1115 53/18722 0.61881282541804 0.782782814156969 ANXA1/P2RX4/PLA2R1 3 GO:0006275 regulation of DNA replication 6/1115 107/18722 0.619053674160375 0.782782814156969 EGFR/ATRX/S100A11/ZBTB38/RBBP6/ANKRD17 6 GO:0070585 protein localization to mitochondrion 7/1115 125/18722 0.62102499680984 0.782782814156969 LMAN1/CALM1/FZD5/UBE2L3/NPEPPS/SREBF2/DNAJA1 7 GO:0071621 granulocyte chemotaxis 7/1115 125/18722 0.62102499680984 0.782782814156969 CSF3R/ANXA1/DPP4/CD74/PPIA/TRPV4/VAV3 7 GO:0000280 nuclear division 25/1115 439/18722 0.621690211442682 0.782782814156969 LRP5/NIPBL/ATRX/BMP7/TPR/RPL24/EML4/PHIP/TOP2B/KPNB1/PDS5B/RANBP1/RAN/ZNF207/SLC2A8/OBSL1/INSR/CDK13/ATM/UBE2C/NUSAP1/CDC20/HSPA1A/MLH3/RHOA 25 GO:0000460 maturation of 5.8S rRNA 2/1115 35/18722 0.625251996054675 0.782782814156969 PRKDC/RPS21 2 GO:0006084 acetyl-CoA metabolic process 2/1115 35/18722 0.625251996054675 0.782782814156969 ACSS1/FASN 2 GO:0006739 NADP metabolic process 2/1115 35/18722 0.625251996054675 0.782782814156969 IDH1/TKT 2 GO:0007020 microtubule nucleation 2/1115 35/18722 0.625251996054675 0.782782814156969 AKAP9/HSPA1A 2 GO:0008608 attachment of spindle microtubules to kinetochore 2/1115 35/18722 0.625251996054675 0.782782814156969 EML4/ZNF207 2 GO:0010664 negative regulation of striated muscle cell apoptotic process 2/1115 35/18722 0.625251996054675 0.782782814156969 BMP7/CFLAR 2 GO:0033280 response to vitamin D 2/1115 35/18722 0.625251996054675 0.782782814156969 ATP2B1/BMP7 2 GO:0034331 cell junction maintenance 2/1115 35/18722 0.625251996054675 0.782782814156969 DLG1/MTSS1 2 GO:0044273 sulfur compound catabolic process 2/1115 35/18722 0.625251996054675 0.782782814156969 GNS/GLB1 2 GO:0045880 positive regulation of smoothened signaling pathway 2/1115 35/18722 0.625251996054675 0.782782814156969 DLG5/GPC3 2 GO:0090181 regulation of cholesterol metabolic process 2/1115 35/18722 0.625251996054675 0.782782814156969 LPCAT3/SOD1 2 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 2/1115 35/18722 0.625251996054675 0.782782814156969 CALM1/DMD 2 GO:1905207 regulation of cardiocyte differentiation 2/1115 35/18722 0.625251996054675 0.782782814156969 EGFR/DHX36 2 GO:0001574 ganglioside biosynthetic process 1/1115 16/18722 0.625757080131475 0.782782814156969 B4GALT5 1 GO:0002713 negative regulation of B cell mediated immunity 1/1115 16/18722 0.625757080131475 0.782782814156969 CD46 1 GO:0002830 positive regulation of type 2 immune response 1/1115 16/18722 0.625757080131475 0.782782814156969 CD74 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/1115 16/18722 0.625757080131475 0.782782814156969 CD46 1 GO:0002921 negative regulation of humoral immune response 1/1115 16/18722 0.625757080131475 0.782782814156969 CD46 1 GO:0006004 fucose metabolic process 1/1115 16/18722 0.625757080131475 0.782782814156969 FUCA1 1 GO:0006266 DNA ligation 1/1115 16/18722 0.625757080131475 0.782782814156969 HMGB1 1 GO:0006349 regulation of gene expression by genetic imprinting 1/1115 16/18722 0.625757080131475 0.782782814156969 DNMT3A 1 GO:0006544 glycine metabolic process 1/1115 16/18722 0.625757080131475 0.782782814156969 GLDC 1 GO:0006740 NADPH regeneration 1/1115 16/18722 0.625757080131475 0.782782814156969 TKT 1 GO:0006828 manganese ion transport 1/1115 16/18722 0.625757080131475 0.782782814156969 SLC11A2 1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1/1115 16/18722 0.625757080131475 0.782782814156969 RPL26 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/1115 16/18722 0.625757080131475 0.782782814156969 XIST 1 GO:0009642 response to light intensity 1/1115 16/18722 0.625757080131475 0.782782814156969 CAT 1 GO:0014819 regulation of skeletal muscle contraction 1/1115 16/18722 0.625757080131475 0.782782814156969 DMD 1 GO:0016584 nucleosome positioning 1/1115 16/18722 0.625757080131475 0.782782814156969 RSF1 1 GO:0030033 microvillus assembly 1/1115 16/18722 0.625757080131475 0.782782814156969 RAPGEF2 1 GO:0030540 female genitalia development 1/1115 16/18722 0.625757080131475 0.782782814156969 LRP2 1 GO:0030575 nuclear body organization 1/1115 16/18722 0.625757080131475 0.782782814156969 SF1 1 GO:0032274 gonadotropin secretion 1/1115 16/18722 0.625757080131475 0.782782814156969 GJA1 1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 1/1115 16/18722 0.625757080131475 0.782782814156969 TCERG1 1 GO:0035067 negative regulation of histone acetylation 1/1115 16/18722 0.625757080131475 0.782782814156969 ZNF451 1 GO:0035864 response to potassium ion 1/1115 16/18722 0.625757080131475 0.782782814156969 SOD1 1 GO:0045721 negative regulation of gluconeogenesis 1/1115 16/18722 0.625757080131475 0.782782814156969 SOGA1 1 GO:0045722 positive regulation of gluconeogenesis 1/1115 16/18722 0.625757080131475 0.782782814156969 DDB1 1 GO:0045838 positive regulation of membrane potential 1/1115 16/18722 0.625757080131475 0.782782814156969 ANK3 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/1115 16/18722 0.625757080131475 0.782782814156969 MPHOSPH8 1 GO:0046037 GMP metabolic process 1/1115 16/18722 0.625757080131475 0.782782814156969 DLG1 1 GO:0048311 mitochondrion distribution 1/1115 16/18722 0.625757080131475 0.782782814156969 TRAK2 1 GO:0048385 regulation of retinoic acid receptor signaling pathway 1/1115 16/18722 0.625757080131475 0.782782814156969 DHRS3 1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 1/1115 16/18722 0.625757080131475 0.782782814156969 FURIN 1 GO:0070200 establishment of protein localization to telomere 1/1115 16/18722 0.625757080131475 0.782782814156969 CCT3 1 GO:0070242 thymocyte apoptotic process 1/1115 16/18722 0.625757080131475 0.782782814156969 GLI3 1 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 1/1115 16/18722 0.625757080131475 0.782782814156969 HSPA1A 1 GO:0071391 cellular response to estrogen stimulus 1/1115 16/18722 0.625757080131475 0.782782814156969 SERPINB9 1 GO:0072283 metanephric renal vesicle morphogenesis 1/1115 16/18722 0.625757080131475 0.782782814156969 CTNNB1 1 GO:0080009 mRNA methylation 1/1115 16/18722 0.625757080131475 0.782782814156969 ZC3H13 1 GO:0090231 regulation of spindle checkpoint 1/1115 16/18722 0.625757080131475 0.782782814156969 TPR 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/1115 16/18722 0.625757080131475 0.782782814156969 TPR 1 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 1/1115 16/18722 0.625757080131475 0.782782814156969 CLSTN1 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/1115 16/18722 0.625757080131475 0.782782814156969 ATP2B1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/1115 16/18722 0.625757080131475 0.782782814156969 SEMA6A 1 GO:1901201 regulation of extracellular matrix assembly 1/1115 16/18722 0.625757080131475 0.782782814156969 DAG1 1 GO:1903504 regulation of mitotic spindle checkpoint 1/1115 16/18722 0.625757080131475 0.782782814156969 TPR 1 GO:1904862 inhibitory synapse assembly 1/1115 16/18722 0.625757080131475 0.782782814156969 PLXNB1 1 GO:1905906 regulation of amyloid fibril formation 1/1115 16/18722 0.625757080131475 0.782782814156969 APP 1 GO:2000001 regulation of DNA damage checkpoint 1/1115 16/18722 0.625757080131475 0.782782814156969 FEM1B 1 GO:2000846 regulation of corticosteroid hormone secretion 1/1115 16/18722 0.625757080131475 0.782782814156969 C1QTNF1 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/1115 16/18722 0.625757080131475 0.782782814156969 PHACTR4 1 GO:2001212 regulation of vasculogenesis 1/1115 16/18722 0.625757080131475 0.782782814156969 RAPGEF2 1 GO:0061097 regulation of protein tyrosine kinase activity 5/1115 90/18722 0.627548703992925 0.784840133665549 APP/ERBB3/ADAM17/CAV1/IBTK 5 GO:0033045 regulation of sister chromatid segregation 4/1115 72/18722 0.628276645984248 0.785198738977037 TPR/ZNF207/ATM/UBE2C 4 GO:0042246 tissue regeneration 4/1115 72/18722 0.628276645984248 0.785198738977037 DAG1/ANXA1/CFLAR/PPP3CA 4 GO:1905818 regulation of chromosome separation 4/1115 72/18722 0.628276645984248 0.785198738977037 TPR/ZNF207/ATM/UBE2C 4 GO:0042594 response to starvation 11/1115 197/18722 0.630955239367396 0.788349066550686 HNRNPA1/SLC2A1/SLC38A2/LAMP2/HSPA5/AOC1/KLF10/CPEB4/BMPR2/SREBF2/ITFG2 11 GO:0031644 regulation of nervous system process 8/1115 144/18722 0.631147487959293 0.788349066550686 AKAP9/DAG1/APP/DICER1/CTSC/SLC9A1/S1PR2/EDNRB 8 GO:0051703 biological process involved in intraspecies interaction between organisms 3/1115 54/18722 0.63153567290453 0.788349066550686 SLC6A4/PCM1/VPS13A 3 GO:0072698 protein localization to microtubule cytoskeleton 3/1115 54/18722 0.63153567290453 0.788349066550686 GOLGB1/CEP350/PCM1 3 GO:2000300 regulation of synaptic vesicle exocytosis 3/1115 54/18722 0.63153567290453 0.788349066550686 CALM1/ATP2A2/RAB3GAP1 3 GO:0016042 lipid catabolic process 18/1115 320/18722 0.633592533533095 0.790731775720709 LRP1/STS/SLC27A2/ASAH1/HEXB/LIPA/HEXA/GM2A/SMPD1/CROT/NCEH1/FUCA1/PLBD1/ECHDC2/CPT2/ABCD3/ACOX1/IDH1 18 GO:0002456 T cell mediated immunity 6/1115 109/18722 0.637051320615591 0.794446115139448 CD46/CTSC/JAG1/FZD5/HMGB1/MR1 6 GO:0032410 negative regulation of transporter activity 6/1115 109/18722 0.637051320615591 0.794446115139448 CALM1/ANK3/YWHAE/C4orf3/CAV1/PKD2 6 GO:0002065 columnar/cuboidal epithelial cell differentiation 5/1115 91/18722 0.637312738554459 0.794446115139448 IL6ST/CDK6/FGFR2/FASN/GPAT4 5 GO:0045582 positive regulation of T cell differentiation 5/1115 91/18722 0.637312738554459 0.794446115139448 CD46/ANXA1/CD74/GLI3/RHOA 5 GO:0051952 regulation of amine transport 5/1115 91/18722 0.637312738554459 0.794446115139448 ITGB1/SLC43A2/ARL6IP5/SYT7/RAB3GAP1 5 GO:0048167 regulation of synaptic plasticity 11/1115 198/18722 0.637616169906935 0.794638826128181 MME/LGMN/APP/SYT7/PPP1R9A/NCSTN/RAB3GAP1/CLN3/PAIP2/RAPGEF2/CDC20 11 GO:0032456 endocytic recycling 4/1115 73/18722 0.639140230056838 0.795271119460785 KIAA1109/RAB11FIP4/CMTM6/RAB13 4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 4/1115 73/18722 0.639140230056838 0.795271119460785 EGFR/IFI6/ADAM17/RHBDF1 4 GO:0051937 catecholamine transport 4/1115 73/18722 0.639140230056838 0.795271119460785 SYT7/NISCH/LY6E/ACTB 4 GO:1904427 positive regulation of calcium ion transmembrane transport 4/1115 73/18722 0.639140230056838 0.795271119460785 CALM1/SLC9A1/PKD2/VMP1 4 GO:0002691 regulation of cellular extravasation 2/1115 36/18722 0.640655756658707 0.795271119460785 CD47/PDGFD 2 GO:0006699 bile acid biosynthetic process 2/1115 36/18722 0.640655756658707 0.795271119460785 SLC27A2/ABCD3 2 GO:0007031 peroxisome organization 2/1115 36/18722 0.640655756658707 0.795271119460785 ABCD3/MAVS 2 GO:0010923 negative regulation of phosphatase activity 2/1115 36/18722 0.640655756658707 0.795271119460785 BOD1L1/ROCK1 2 GO:0016180 snRNA processing 2/1115 36/18722 0.640655756658707 0.795271119460785 INTS6/INTS1 2 GO:0042092 type 2 immune response 2/1115 36/18722 0.640655756658707 0.795271119460785 ANXA1/CD74 2 GO:0044060 regulation of endocrine process 2/1115 36/18722 0.640655756658707 0.795271119460785 GJA1/C1QTNF1 2 GO:0045191 regulation of isotype switching 2/1115 36/18722 0.640655756658707 0.795271119460785 RIF1/TFRC 2 GO:0051354 negative regulation of oxidoreductase activity 2/1115 36/18722 0.640655756658707 0.795271119460785 ATP2B4/CAV1 2 GO:0060338 regulation of type I interferon-mediated signaling pathway 2/1115 36/18722 0.640655756658707 0.795271119460785 HSP90AB1/MAVS 2 GO:0070897 transcription preinitiation complex assembly 2/1115 36/18722 0.640655756658707 0.795271119460785 HMGB1/ATF7IP 2 GO:0097009 energy homeostasis 2/1115 36/18722 0.640655756658707 0.795271119460785 TRPV4/TSKU 2 GO:1901658 glycosyl compound catabolic process 2/1115 36/18722 0.640655756658707 0.795271119460785 GUSB/FUCA1 2 GO:0008333 endosome to lysosome transport 3/1115 55/18722 0.643960847993877 0.795405946841186 HOOK2/SCYL2/TRAK2 3 GO:0045017 glycerolipid biosynthetic process 14/1115 252/18722 0.644768187935189 0.795405946841186 PGAP1/SLC44A2/CDS1/SMG1/GPAA1/SLC44A1/CLN3/ACSL3/PISD/LPCAT3/AGPAT1/ATM/GPAT4/ETNK1 14 GO:0048525 negative regulation of viral process 5/1115 92/18722 0.646917225520188 0.795405946841186 PPIA/MPHOSPH8/LY6E/MAVS/TRIM13 5 GO:0002700 regulation of production of molecular mediator of immune response 9/1115 164/18722 0.647682707409122 0.795405946841186 CD74/PRKDC/RIF1/TFRC/FZD5/DHX36/SEMA7A/TLR3/MAVS 9 GO:0000097 sulfur amino acid biosynthetic process 1/1115 17/18722 0.648064406959947 0.795405946841186 MTR 1 GO:0001710 mesodermal cell fate commitment 1/1115 17/18722 0.648064406959947 0.795405946841186 BMPR1A 1 GO:0006474 N-terminal protein amino acid acetylation 1/1115 17/18722 0.648064406959947 0.795405946841186 CREBBP 1 GO:0007076 mitotic chromosome condensation 1/1115 17/18722 0.648064406959947 0.795405946841186 NUSAP1 1 GO:0007096 regulation of exit from mitosis 1/1115 17/18722 0.648064406959947 0.795405946841186 UBE2C 1 GO:0007351 tripartite regional subdivision 1/1115 17/18722 0.648064406959947 0.795405946841186 FZD5 1 GO:0008340 determination of adult lifespan 1/1115 17/18722 0.648064406959947 0.795405946841186 TFCP2L1 1 GO:0008595 anterior/posterior axis specification, embryo 1/1115 17/18722 0.648064406959947 0.795405946841186 FZD5 1 GO:0009200 deoxyribonucleoside triphosphate metabolic process 1/1115 17/18722 0.648064406959947 0.795405946841186 RRM2B 1 GO:0010224 response to UV-B 1/1115 17/18722 0.648064406959947 0.795405946841186 MME 1 GO:0010470 regulation of gastrulation 1/1115 17/18722 0.648064406959947 0.795405946841186 DAG1 1 GO:0010566 regulation of ketone biosynthetic process 1/1115 17/18722 0.648064406959947 0.795405946841186 REST 1 GO:0010831 positive regulation of myotube differentiation 1/1115 17/18722 0.648064406959947 0.795405946841186 MAPK14 1 GO:0014856 skeletal muscle cell proliferation 1/1115 17/18722 0.648064406959947 0.795405946841186 CFLAR 1 GO:0020027 hemoglobin metabolic process 1/1115 17/18722 0.648064406959947 0.795405946841186 CAT 1 GO:0021513 spinal cord dorsal/ventral patterning 1/1115 17/18722 0.648064406959947 0.795405946841186 GLI3 1 GO:0030322 stabilization of membrane potential 1/1115 17/18722 0.648064406959947 0.795405946841186 KCNN4 1 GO:0030903 notochord development 1/1115 17/18722 0.648064406959947 0.795405946841186 COBL 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/1115 17/18722 0.648064406959947 0.795405946841186 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/1115 17/18722 0.648064406959947 0.795405946841186 ISL1 1 GO:0033623 regulation of integrin activation 1/1115 17/18722 0.648064406959947 0.795405946841186 FERMT1 1 GO:0034349 glial cell apoptotic process 1/1115 17/18722 0.648064406959947 0.795405946841186 PRKCI 1 GO:0035269 protein O-linked mannosylation 1/1115 17/18722 0.648064406959947 0.795405946841186 TMTC3 1 GO:0035855 megakaryocyte development 1/1115 17/18722 0.648064406959947 0.795405946841186 WASF2 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/1115 17/18722 0.648064406959947 0.795405946841186 ATM 1 GO:0042772 DNA damage response, signal transduction resulting in transcription 1/1115 17/18722 0.648064406959947 0.795405946841186 RPL26 1 GO:0043950 positive regulation of cAMP-mediated signaling 1/1115 17/18722 0.648064406959947 0.795405946841186 RAPGEF2 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/1115 17/18722 0.648064406959947 0.795405946841186 CD46 1 GO:0046068 cGMP metabolic process 1/1115 17/18722 0.648064406959947 0.795405946841186 PDE10A 1 GO:0048243 norepinephrine secretion 1/1115 17/18722 0.648064406959947 0.795405946841186 NISCH 1 GO:0051580 regulation of neurotransmitter uptake 1/1115 17/18722 0.648064406959947 0.795405946841186 ITGB1 1 GO:0051797 regulation of hair follicle development 1/1115 17/18722 0.648064406959947 0.795405946841186 FERMT1 1 GO:0055003 cardiac myofibril assembly 1/1115 17/18722 0.648064406959947 0.795405946841186 OBSL1 1 GO:0055064 chloride ion homeostasis 1/1115 17/18722 0.648064406959947 0.795405946841186 ATP6V1B1 1 GO:0055083 monovalent inorganic anion homeostasis 1/1115 17/18722 0.648064406959947 0.795405946841186 ATP6V1B1 1 GO:0070593 dendrite self-avoidance 1/1115 17/18722 0.648064406959947 0.795405946841186 PALLD 1 GO:0090036 regulation of protein kinase C signaling 1/1115 17/18722 0.648064406959947 0.795405946841186 GPD1L 1 GO:0090083 regulation of inclusion body assembly 1/1115 17/18722 0.648064406959947 0.795405946841186 HSPA1A 1 GO:0090713 immunological memory process 1/1115 17/18722 0.648064406959947 0.795405946841186 CD46 1 GO:0097067 cellular response to thyroid hormone stimulus 1/1115 17/18722 0.648064406959947 0.795405946841186 CTSB 1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 1/1115 17/18722 0.648064406959947 0.795405946841186 AKAP9 1 GO:1901569 fatty acid derivative catabolic process 1/1115 17/18722 0.648064406959947 0.795405946841186 HPGD 1 GO:1903540 establishment of protein localization to postsynaptic membrane 1/1115 17/18722 0.648064406959947 0.795405946841186 CLSTN1 1 GO:1903818 positive regulation of voltage-gated potassium channel activity 1/1115 17/18722 0.648064406959947 0.795405946841186 ALG10B 1 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 1/1115 17/18722 0.648064406959947 0.795405946841186 CTNNB1 1 GO:0009260 ribonucleotide biosynthetic process 10/1115 182/18722 0.649110142099024 0.796506331571291 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/ACSL3/ELOVL1 10 GO:0002437 inflammatory response to antigenic stimulus 4/1115 74/18722 0.64979446983603 0.796979709270518 FURIN/RBPJ/HMGB1/MAPK14 4 GO:1901568 fatty acid derivative metabolic process 4/1115 74/18722 0.64979446983603 0.796979709270518 TECR/ACSL3/ELOVL1/HPGD 4 GO:0045088 regulation of innate immune response 12/1115 218/18722 0.652526719933527 0.800147027497726 GRN/PRKDC/HSP90AB1/PARP14/HMGB1/APPL1/XIAP/ERAP1/MAVS/CREBBP/SERPINB9/CADM1 12 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2/1115 37/18722 0.655555911493354 0.801101627709549 SMG1/DCP2 2 GO:0014904 myotube cell development 2/1115 37/18722 0.655555911493354 0.801101627709549 PLEC/PPP3CA 2 GO:0016202 regulation of striated muscle tissue development 2/1115 37/18722 0.655555911493354 0.801101627709549 CTNNB1/YBX3 2 GO:0031646 positive regulation of nervous system process 2/1115 37/18722 0.655555911493354 0.801101627709549 DAG1/DICER1 2 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 2/1115 37/18722 0.655555911493354 0.801101627709549 GPC1/CTNNB1 2 GO:0043029 T cell homeostasis 2/1115 37/18722 0.655555911493354 0.801101627709549 RPS6/RC3H1 2 GO:0045730 respiratory burst 2/1115 37/18722 0.655555911493354 0.801101627709549 GRN/INSR 2 GO:0046473 phosphatidic acid metabolic process 2/1115 37/18722 0.655555911493354 0.801101627709549 AGPAT1/GPAT4 2 GO:0051294 establishment of spindle orientation 2/1115 37/18722 0.655555911493354 0.801101627709549 ITGB1/GJA1 2 GO:0051954 positive regulation of amine transport 2/1115 37/18722 0.655555911493354 0.801101627709549 ITGB1/RAB3GAP1 2 GO:0071542 dopaminergic neuron differentiation 2/1115 37/18722 0.655555911493354 0.801101627709549 RYK/CTNNB1 2 GO:0072529 pyrimidine-containing compound catabolic process 2/1115 37/18722 0.655555911493354 0.801101627709549 TET2/TDG 2 GO:0090218 positive regulation of lipid kinase activity 2/1115 37/18722 0.655555911493354 0.801101627709549 FLT1/VAV3 2 GO:0097484 dendrite extension 2/1115 37/18722 0.655555911493354 0.801101627709549 ITSN2/CYFIP2 2 GO:1900016 negative regulation of cytokine production involved in inflammatory response 2/1115 37/18722 0.655555911493354 0.801101627709549 ADCY7/CHID1 2 GO:0002819 regulation of adaptive immune response 10/1115 183/18722 0.655890625231265 0.801327242130372 CD46/IL6ST/ANXA1/RIF1/TFRC/FZD5/ADCY7/HMGB1/RC3H1/MR1 10 GO:0006352 DNA-templated transcription, initiation 7/1115 130/18722 0.661892225546511 0.805427708995579 ZNF451/RSF1/MED13/DHX36/HMGB1/ATF7IP/SUB1 7 GO:0030534 adult behavior 7/1115 130/18722 0.661892225546511 0.805427708995579 APP/ATP6V1B1/NPC1/NCSTN/CLCN3/PUM1/OXR1 7 GO:0010633 negative regulation of epithelial cell migration 6/1115 112/18722 0.663080366101323 0.805427708995579 ATP2B4/SERPINF1/NR2F2/PTPRM/HMGB1/RHOA 6 GO:0046632 alpha-beta T cell differentiation 6/1115 112/18722 0.663080366101323 0.805427708995579 ANXA1/GLI3/FOXP1/HMGB1/RC3H1/RHOA 6 GO:0032091 negative regulation of protein binding 5/1115 94/18722 0.665639279544008 0.805427708995579 PTPRF/ATP2A2/ROCK1/CAV1/ACTB 5 GO:0006695 cholesterol biosynthetic process 3/1115 57/18722 0.667912709105507 0.805427708995579 DHCR24/LPCAT3/SOD1 3 GO:0006754 ATP biosynthetic process 3/1115 57/18722 0.667912709105507 0.805427708995579 ALDOA/ENO1/TMSB4X 3 GO:0016447 somatic recombination of immunoglobulin gene segments 3/1115 57/18722 0.667912709105507 0.805427708995579 PRKDC/RIF1/TFRC 3 GO:0050879 multicellular organismal movement 3/1115 57/18722 0.667912709105507 0.805427708995579 GAA/ATP2A2/DMD 3 GO:0050881 musculoskeletal movement 3/1115 57/18722 0.667912709105507 0.805427708995579 GAA/ATP2A2/DMD 3 GO:1902653 secondary alcohol biosynthetic process 3/1115 57/18722 0.667912709105507 0.805427708995579 DHCR24/LPCAT3/SOD1 3 GO:0000712 resolution of meiotic recombination intermediates 1/1115 18/18722 0.66904319264504 0.805427708995579 TOP2B 1 GO:0001956 positive regulation of neurotransmitter secretion 1/1115 18/18722 0.66904319264504 0.805427708995579 RAB3GAP1 1 GO:0002076 osteoblast development 1/1115 18/18722 0.66904319264504 0.805427708995579 LRP5 1 GO:0002223 stimulatory C-type lectin receptor signaling pathway 1/1115 18/18722 0.66904319264504 0.805427708995579 CREBBP 1 GO:0002544 chronic inflammatory response 1/1115 18/18722 0.66904319264504 0.805427708995579 GJA1 1 GO:0002643 regulation of tolerance induction 1/1115 18/18722 0.66904319264504 0.805427708995579 HMGB1 1 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 1/1115 18/18722 0.66904319264504 0.805427708995579 CD46 1 GO:0003417 growth plate cartilage development 1/1115 18/18722 0.66904319264504 0.805427708995579 TSKU 1 GO:0006085 acetyl-CoA biosynthetic process 1/1115 18/18722 0.66904319264504 0.805427708995579 ACSS1 1 GO:0006103 2-oxoglutarate metabolic process 1/1115 18/18722 0.66904319264504 0.805427708995579 IDH1 1 GO:0006415 translational termination 1/1115 18/18722 0.66904319264504 0.805427708995579 EIF5A 1 GO:0007250 activation of NF-kappaB-inducing kinase activity 1/1115 18/18722 0.66904319264504 0.805427708995579 TLR3 1 GO:0007549 dosage compensation 1/1115 18/18722 0.66904319264504 0.805427708995579 XIST 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/1115 18/18722 0.66904319264504 0.805427708995579 AK3 1 GO:0015732 prostaglandin transport 1/1115 18/18722 0.66904319264504 0.805427708995579 P2RX4 1 GO:0015936 coenzyme A metabolic process 1/1115 18/18722 0.66904319264504 0.805427708995579 CROT 1 GO:0019184 nonribosomal peptide biosynthetic process 1/1115 18/18722 0.66904319264504 0.805427708995579 AASDH 1 GO:0019896 axonal transport of mitochondrion 1/1115 18/18722 0.66904319264504 0.805427708995579 TRAK2 1 GO:0021511 spinal cord patterning 1/1115 18/18722 0.66904319264504 0.805427708995579 GLI3 1 GO:0030299 intestinal cholesterol absorption 1/1115 18/18722 0.66904319264504 0.805427708995579 LPCAT3 1 GO:0032785 negative regulation of DNA-templated transcription, elongation 1/1115 18/18722 0.66904319264504 0.805427708995579 TCERG1 1 GO:0034134 toll-like receptor 2 signaling pathway 1/1115 18/18722 0.66904319264504 0.805427708995579 HMGB1 1 GO:0035930 corticosteroid hormone secretion 1/1115 18/18722 0.66904319264504 0.805427708995579 C1QTNF1 1 GO:0042136 neurotransmitter biosynthetic process 1/1115 18/18722 0.66904319264504 0.805427708995579 SLC6A4 1 GO:0042693 muscle cell fate commitment 1/1115 18/18722 0.66904319264504 0.805427708995579 RBPJ 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/1115 18/18722 0.66904319264504 0.805427708995579 NCL 1 GO:0045116 protein neddylation 1/1115 18/18722 0.66904319264504 0.805427708995579 RPL5 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/1115 18/18722 0.66904319264504 0.805427708995579 ADRB1 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/1115 18/18722 0.66904319264504 0.805427708995579 SERPINB9 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/1115 18/18722 0.66904319264504 0.805427708995579 SYT7 1 GO:0048535 lymph node development 1/1115 18/18722 0.66904319264504 0.805427708995579 RC3H1 1 GO:0048643 positive regulation of skeletal muscle tissue development 1/1115 18/18722 0.66904319264504 0.805427708995579 CTNNB1 1 GO:0051382 kinetochore assembly 1/1115 18/18722 0.66904319264504 0.805427708995579 SENP6 1 GO:0051895 negative regulation of focal adhesion assembly 1/1115 18/18722 0.66904319264504 0.805427708995579 LRP1 1 GO:0060438 trachea development 1/1115 18/18722 0.66904319264504 0.805427708995579 CTNNB1 1 GO:0060457 negative regulation of digestive system process 1/1115 18/18722 0.66904319264504 0.805427708995579 WNK1 1 GO:0060602 branch elongation of an epithelium 1/1115 18/18722 0.66904319264504 0.805427708995579 FGFR2 1 GO:0090493 catecholamine uptake 1/1115 18/18722 0.66904319264504 0.805427708995579 ACTB 1 GO:0097094 craniofacial suture morphogenesis 1/1115 18/18722 0.66904319264504 0.805427708995579 GLI3 1 GO:0098877 neurotransmitter receptor transport to plasma membrane 1/1115 18/18722 0.66904319264504 0.805427708995579 CLSTN1 1 GO:0099558 maintenance of synapse structure 1/1115 18/18722 0.66904319264504 0.805427708995579 DLG1 1 GO:0110154 RNA decapping 1/1115 18/18722 0.66904319264504 0.805427708995579 DCP2 1 GO:0150078 positive regulation of neuroinflammatory response 1/1115 18/18722 0.66904319264504 0.805427708995579 CTSC 1 GO:0150079 negative regulation of neuroinflammatory response 1/1115 18/18722 0.66904319264504 0.805427708995579 GRN 1 GO:0150118 negative regulation of cell-substrate junction organization 1/1115 18/18722 0.66904319264504 0.805427708995579 LRP1 1 GO:1990840 response to lectin 1/1115 18/18722 0.66904319264504 0.805427708995579 CREBBP 1 GO:1990858 cellular response to lectin 1/1115 18/18722 0.66904319264504 0.805427708995579 CREBBP 1 GO:0002040 sprouting angiogenesis 10/1115 185/18722 0.669227518299954 0.805427708995579 ITGB1/ANXA1/NRP1/SEMA6A/EPHB4/MIA3/AKT3/HMGB1/RNF213/RHOA 10 GO:0001825 blastocyst formation 2/1115 38/18722 0.66995775531923 0.805427708995579 RTN4/FURIN 2 GO:0006882 cellular zinc ion homeostasis 2/1115 38/18722 0.66995775531923 0.805427708995579 SLC39A10/SLC30A7 2 GO:0010742 macrophage derived foam cell differentiation 2/1115 38/18722 0.66995775531923 0.805427708995579 ITGAV/ABCA1 2 GO:0030279 negative regulation of ossification 2/1115 38/18722 0.66995775531923 0.805427708995579 LTBP3/RBPJ 2 GO:0032717 negative regulation of interleukin-8 production 2/1115 38/18722 0.66995775531923 0.805427708995579 ANXA1/TMSB4X 2 GO:0046676 negative regulation of insulin secretion 2/1115 38/18722 0.66995775531923 0.805427708995579 PPP3CA/REST 2 GO:0051930 regulation of sensory perception of pain 2/1115 38/18722 0.66995775531923 0.805427708995579 SLC9A1/EDNRB 2 GO:0090077 foam cell differentiation 2/1115 38/18722 0.66995775531923 0.805427708995579 ITGAV/ABCA1 2 GO:0098926 postsynaptic signal transduction 2/1115 38/18722 0.66995775531923 0.805427708995579 GNAQ/LY6E 2 GO:1901031 regulation of response to reactive oxygen species 2/1115 38/18722 0.66995775531923 0.805427708995579 MET/BMP7 2 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 2/1115 38/18722 0.66995775531923 0.805427708995579 SLC35F6/HSPA1A 2 GO:1903725 regulation of phospholipid metabolic process 2/1115 38/18722 0.66995775531923 0.805427708995579 ACSL3/IDH1 2 GO:0007131 reciprocal meiotic recombination 3/1115 58/18722 0.679438487574737 0.81609045785411 TOP2B/ATM/MLH3 3 GO:0044380 protein localization to cytoskeleton 3/1115 58/18722 0.679438487574737 0.81609045785411 GOLGB1/CEP350/PCM1 3 GO:0050432 catecholamine secretion 3/1115 58/18722 0.679438487574737 0.81609045785411 SYT7/NISCH/LY6E 3 GO:0140527 reciprocal homologous recombination 3/1115 58/18722 0.679438487574737 0.81609045785411 TOP2B/ATM/MLH3 3 GO:0002200 somatic diversification of immune receptors 4/1115 77/18722 0.680482835342182 0.817161011671594 PRKDC/RIF1/TFRC/HMGB1 4 GO:0002695 negative regulation of leukocyte activation 10/1115 187/18722 0.682258876855501 0.817553655389707 GRN/ANXA1/CD74/DLG5/DLG1/GLI3/HMGB1/RC3H1/ATM/ERBB2 10 GO:0018394 peptidyl-lysine acetylation 9/1115 169/18722 0.682547271031256 0.817553655389707 NCOA3/MORF4L2/RPS6KA5/ZNF451/JADE1/KMT2A/ISL1/CREBBP/MORF4L1 9 GO:0019932 second-messenger-mediated signaling 17/1115 312/18722 0.682918527639855 0.817553655389707 EGFR/ATP2B4/CALM1/NFAT5/P2RX4/ITPR2/SLC9A1/ATP2A2/PPP1R9A/DMD/NFATC3/EDNRB/PPP3CA/PDE10A/PDE7A/MCTP2/RAPGEF2 17 GO:0071824 protein-DNA complex subunit organization 13/1115 241/18722 0.68355822083983 0.817553655389707 RPL23/NPM1/ATRX/BPTF/ARID1A/RSF1/SMARCC1/SENP6/PIAS1/SETD2/HMGB1/ATF7IP/SHPRH 13 GO:0043648 dicarboxylic acid metabolic process 5/1115 96/18722 0.683701238752071 0.817553655389707 SLC19A1/FOLR1/ALDH18A1/ALDH4A1/IDH1 5 GO:0051304 chromosome separation 5/1115 96/18722 0.683701238752071 0.817553655389707 TPR/TOP2B/ZNF207/ATM/UBE2C 5 GO:0016572 histone phosphorylation 2/1115 39/18722 0.683867738017028 0.817553655389707 RPS6KA5/ATM 2 GO:0043267 negative regulation of potassium ion transport 2/1115 39/18722 0.683867738017028 0.817553655389707 ANK3/CAV1 2 GO:0045622 regulation of T-helper cell differentiation 2/1115 39/18722 0.683867738017028 0.817553655389707 ANXA1/RC3H1 2 GO:0045923 positive regulation of fatty acid metabolic process 2/1115 39/18722 0.683867738017028 0.817553655389707 ANXA1/CD74 2 GO:0051931 regulation of sensory perception 2/1115 39/18722 0.683867738017028 0.817553655389707 SLC9A1/EDNRB 2 GO:1901861 regulation of muscle tissue development 2/1115 39/18722 0.683867738017028 0.817553655389707 CTNNB1/YBX3 2 GO:0009855 determination of bilateral symmetry 7/1115 133/18722 0.685081004028107 0.817553655389707 GALNT11/FOLR1/MIB1/SMAD2/AHI1/PKD2/CTNNB1 7 GO:0010565 regulation of cellular ketone metabolic process 7/1115 133/18722 0.685081004028107 0.817553655389707 ANXA1/ATP2B4/CD74/NCOR1/CLN3/CAV1/REST 7 GO:0009117 nucleotide metabolic process 27/1115 489/18722 0.687039197889133 0.817553655389707 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RRM2B/RAN/ACSL3/INSR/PDE10A/PDE7A/TDG/ELOVL1/FASN/GPAT4/RHOA 27 GO:0043279 response to alkaloid 6/1115 115/18722 0.687907285562582 0.817553655389707 HSP90AB1/DNMT3A/HSPA5/SLC1A3/SMPD1/SRSF9 6 GO:0051209 release of sequestered calcium ion into cytosol 6/1115 115/18722 0.687907285562582 0.817553655389707 CALM1/ITPR2/MCOLN3/DMD/PKD2/IBTK 6 GO:0002396 MHC protein complex assembly 1/1115 19/18722 0.68877249334012 0.817553655389707 TAPBP 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/1115 19/18722 0.68877249334012 0.817553655389707 SERPINB9 1 GO:0006071 glycerol metabolic process 1/1115 19/18722 0.68877249334012 0.817553655389707 TPI1 1 GO:0006309 apoptotic DNA fragmentation 1/1115 19/18722 0.68877249334012 0.817553655389707 DICER1 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/1115 19/18722 0.68877249334012 0.817553655389707 GNAQ 1 GO:0007530 sex determination 1/1115 19/18722 0.68877249334012 0.817553655389707 SF1 1 GO:0007603 phototransduction, visible light 1/1115 19/18722 0.68877249334012 0.817553655389707 GNAQ 1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 1/1115 19/18722 0.68877249334012 0.817553655389707 TDG 1 GO:0009226 nucleotide-sugar biosynthetic process 1/1115 19/18722 0.68877249334012 0.817553655389707 UXS1 1 GO:0010544 negative regulation of platelet activation 1/1115 19/18722 0.68877249334012 0.817553655389707 C1QTNF1 1 GO:0010738 regulation of protein kinase A signaling 1/1115 19/18722 0.68877249334012 0.817553655389707 MIF 1 GO:0010759 positive regulation of macrophage chemotaxis 1/1115 19/18722 0.68877249334012 0.817553655389707 TRPV4 1 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 1/1115 19/18722 0.68877249334012 0.817553655389707 PIK3IP1 1 GO:0030220 platelet formation 1/1115 19/18722 0.68877249334012 0.817553655389707 PRKDC 1 GO:0031065 positive regulation of histone deacetylation 1/1115 19/18722 0.68877249334012 0.817553655389707 NIPBL 1 GO:0036344 platelet morphogenesis 1/1115 19/18722 0.68877249334012 0.817553655389707 PRKDC 1 GO:0038092 nodal signaling pathway 1/1115 19/18722 0.68877249334012 0.817553655389707 SMAD2 1 GO:0043031 negative regulation of macrophage activation 1/1115 19/18722 0.68877249334012 0.817553655389707 GRN 1 GO:0043652 engulfment of apoptotic cell 1/1115 19/18722 0.68877249334012 0.817553655389707 RHOBTB1 1 GO:0044827 modulation by host of viral genome replication 1/1115 19/18722 0.68877249334012 0.817553655389707 STOM 1 GO:0045603 positive regulation of endothelial cell differentiation 1/1115 19/18722 0.68877249334012 0.817553655389707 CTNNB1 1 GO:0045618 positive regulation of keratinocyte differentiation 1/1115 19/18722 0.68877249334012 0.817553655389707 NCOA3 1 GO:0046033 AMP metabolic process 1/1115 19/18722 0.68877249334012 0.817553655389707 AK3 1 GO:0046794 transport of virus 1/1115 19/18722 0.68877249334012 0.817553655389707 CAV1 1 GO:0051546 keratinocyte migration 1/1115 19/18722 0.68877249334012 0.817553655389707 FERMT1 1 GO:0060216 definitive hemopoiesis 1/1115 19/18722 0.68877249334012 0.817553655389707 TGFBR3 1 GO:0070233 negative regulation of T cell apoptotic process 1/1115 19/18722 0.68877249334012 0.817553655389707 DOCK8 1 GO:0070734 histone H3-K27 methylation 1/1115 19/18722 0.68877249334012 0.817553655389707 SUZ12 1 GO:0072077 renal vesicle morphogenesis 1/1115 19/18722 0.68877249334012 0.817553655389707 CTNNB1 1 GO:0097501 stress response to metal ion 1/1115 19/18722 0.68877249334012 0.817553655389707 HSPA5 1 GO:0098780 response to mitochondrial depolarisation 1/1115 19/18722 0.68877249334012 0.817553655389707 VPS13C 1 GO:2000042 negative regulation of double-strand break repair via homologous recombination 1/1115 19/18722 0.68877249334012 0.817553655389707 RIF1 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/1115 19/18722 0.68877249334012 0.817553655389707 NRP1 1 GO:2000319 regulation of T-helper 17 cell differentiation 1/1115 19/18722 0.68877249334012 0.817553655389707 RC3H1 1 GO:2000831 regulation of steroid hormone secretion 1/1115 19/18722 0.68877249334012 0.817553655389707 C1QTNF1 1 GO:0019221 cytokine-mediated signaling pathway 26/1115 472/18722 0.689215711614503 0.817760393885531 CSF3R/IL6ST/KRT8/PRLR/SPPL2A/CD74/LIFR/HSP90AB1/KRT18/RPS6KA5/IL10RB/ACTN4/GSTP1/P4HB/TRIM44/PARP14/ADAM17/WNK1/TMSB4X/SPPL2B/CAV1/APPL1/AGPAT1/EIF5A/MAVS/HSPA1A 26 GO:0019216 regulation of lipid metabolic process 18/1115 331/18722 0.689253001027325 0.817760393885531 ANXA1/PSAP/FLT1/ASAH1/CD74/SF1/ORMDL1/NCOR1/SORBS1/ATP1A1/VAV3/CAV1/ACSL3/LPCAT3/PIK3IP1/REST/IDH1/SOD1 18 GO:0061045 negative regulation of wound healing 4/1115 78/18722 0.690283547953445 0.818290077681826 GJA1/TFPI/C1QTNF1/ANXA2 4 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 4/1115 78/18722 0.690283547953445 0.818290077681826 ANXA1/NRP1/AKT3/RHOA 4 GO:0090559 regulation of membrane permeability 4/1115 78/18722 0.690283547953445 0.818290077681826 SLC9A1/F11R/SLC35F6/HSPA1A 4 GO:0090501 RNA phosphodiester bond hydrolysis 8/1115 152/18722 0.690489076833456 0.818290077681826 DICER1/RPS21/CNOT6L/XRN1/DCP2/AGO2/MOV10/SND1 8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 3/1115 59/18722 0.690664670614404 0.818290077681826 FLT1/VAV3/PIK3IP1 3 GO:0048278 vesicle docking 3/1115 59/18722 0.690664670614404 0.818290077681826 USO1/CLN3/RAB13 3 GO:0031349 positive regulation of defense response 15/1115 278/18722 0.690772313188236 0.818290077681826 EGFR/NEAT1/IL6ST/GRN/APP/CTSC/GJA1/PRKDC/CD47/TRPV4/HMGB1/TLR3/MAVS/CREBBP/CADM1 15 GO:1901216 positive regulation of neuron death 5/1115 97/18722 0.692481646702743 0.819886714699473 GRN/NF1/REST/CTNNB1/RHOA 5 GO:0002705 positive regulation of leukocyte mediated immunity 7/1115 134/18722 0.692580835979513 0.819886714699473 RIF1/TFRC/FZD5/DHX36/MAVS/MR1/CADM1 7 GO:0009799 specification of symmetry 7/1115 134/18722 0.692580835979513 0.819886714699473 GALNT11/FOLR1/MIB1/SMAD2/AHI1/PKD2/CTNNB1 7 GO:0043543 protein acylation 13/1115 243/18722 0.694808095307457 0.822341037651633 NCOA3/MORF4L2/RPS6KA5/TAOK1/ZNF451/ZDHHC20/JADE1/KMT2A/ZDHHC17/ZDHHC21/ISL1/CREBBP/MORF4L1 13 GO:0051283 negative regulation of sequestering of calcium ion 6/1115 116/18722 0.695909884453678 0.822547276604314 CALM1/ITPR2/MCOLN3/DMD/PKD2/IBTK 6 GO:0002714 positive regulation of B cell mediated immunity 2/1115 40/18722 0.697293308468089 0.822547276604314 RIF1/TFRC 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/1115 40/18722 0.697293308468089 0.822547276604314 RIF1/TFRC 2 GO:0009069 serine family amino acid metabolic process 2/1115 40/18722 0.697293308468089 0.822547276604314 GLDC/SERINC3 2 GO:0031111 negative regulation of microtubule polymerization or depolymerization 2/1115 40/18722 0.697293308468089 0.822547276604314 TAOK1/CAMSAP2 2 GO:0031297 replication fork processing 2/1115 40/18722 0.697293308468089 0.822547276604314 BOD1L1/ATRX 2 GO:0032094 response to food 2/1115 40/18722 0.697293308468089 0.822547276604314 PLEC/SLC16A1 2 GO:0045022 early endosome to late endosome transport 2/1115 40/18722 0.697293308468089 0.822547276604314 EEA1/HOOK2 2 GO:0045740 positive regulation of DNA replication 2/1115 40/18722 0.697293308468089 0.822547276604314 EGFR/ATRX 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/1115 40/18722 0.697293308468089 0.822547276604314 CALM1/PKD2 2 GO:0055069 zinc ion homeostasis 2/1115 40/18722 0.697293308468089 0.822547276604314 SLC39A10/SLC30A7 2 GO:0071276 cellular response to cadmium ion 2/1115 40/18722 0.697293308468089 0.822547276604314 EGFR/SOD1 2 GO:0150077 regulation of neuroinflammatory response 2/1115 40/18722 0.697293308468089 0.822547276604314 GRN/CTSC 2 GO:1901223 negative regulation of NIK/NF-kappaB signaling 2/1115 40/18722 0.697293308468089 0.822547276604314 BMP7/TMSB4X 2 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 2/1115 40/18722 0.697293308468089 0.822547276604314 SLC35F6/HSPA1A 2 GO:0043473 pigmentation 5/1115 98/18722 0.701093910823307 0.826158312855675 NF1/GLI3/MYO7A/HPS5/EDNRB 5 GO:0070301 cellular response to hydrogen peroxide 5/1115 98/18722 0.701093910823307 0.826158312855675 MET/ANXA1/RPS3/NET1/PDGFD 5 GO:0009566 fertilization 10/1115 190/18722 0.701217841506019 0.826158312855675 CD46/ASH1L/ALDOA/HEXB/B4GALT1/FOLR1/NR2F2/ZFX/CCT3/YBX3 10 GO:0002712 regulation of B cell mediated immunity 3/1115 60/18722 0.70159239379802 0.826158312855675 CD46/RIF1/TFRC 3 GO:0002889 regulation of immunoglobulin mediated immune response 3/1115 60/18722 0.70159239379802 0.826158312855675 CD46/RIF1/TFRC 3 GO:0035825 homologous recombination 3/1115 60/18722 0.70159239379802 0.826158312855675 TOP2B/ATM/MLH3 3 GO:0051851 modulation by host of symbiont process 3/1115 60/18722 0.70159239379802 0.826158312855675 CFL1/STOM/REST 3 GO:0051965 positive regulation of synapse assembly 3/1115 60/18722 0.70159239379802 0.826158312855675 DLG5/CLSTN1/TPBG 3 GO:0099024 plasma membrane invagination 7/1115 136/18722 0.707230399628644 0.826590051004816 ABCA1/ANO6/SNX18/CLCN3/RHOBTB1/RAB31/RHOA 7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/1115 20/18722 0.707326664859436 0.826590051004816 BRD4 1 GO:0002577 regulation of antigen processing and presentation 1/1115 20/18722 0.707326664859436 0.826590051004816 CD74 1 GO:0006448 regulation of translational elongation 1/1115 20/18722 0.707326664859436 0.826590051004816 EIF5A 1 GO:0006590 thyroid hormone generation 1/1115 20/18722 0.707326664859436 0.826590051004816 CTSB 1 GO:0006700 C21-steroid hormone biosynthetic process 1/1115 20/18722 0.707326664859436 0.826590051004816 REST 1 GO:0006837 serotonin transport 1/1115 20/18722 0.707326664859436 0.826590051004816 SLC6A4 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/1115 20/18722 0.707326664859436 0.826590051004816 VDAC1 1 GO:0006896 Golgi to vacuole transport 1/1115 20/18722 0.707326664859436 0.826590051004816 CLN3 1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1/1115 20/18722 0.707326664859436 0.826590051004816 CALM1 1 GO:0015919 peroxisomal membrane transport 1/1115 20/18722 0.707326664859436 0.826590051004816 ABCD3 1 GO:0016553 base conversion or substitution editing 1/1115 20/18722 0.707326664859436 0.826590051004816 RBM47 1 GO:0017121 plasma membrane phospholipid scrambling 1/1115 20/18722 0.707326664859436 0.826590051004816 ANO6 1 GO:0031645 negative regulation of nervous system process 1/1115 20/18722 0.707326664859436 0.826590051004816 CTSC 1 GO:0032332 positive regulation of chondrocyte differentiation 1/1115 20/18722 0.707326664859436 0.826590051004816 GLI3 1 GO:0032793 positive regulation of CREB transcription factor activity 1/1115 20/18722 0.707326664859436 0.826590051004816 RPS6KA5 1 GO:0043046 DNA methylation involved in gamete generation 1/1115 20/18722 0.707326664859436 0.826590051004816 DNMT3A 1 GO:0043691 reverse cholesterol transport 1/1115 20/18722 0.707326664859436 0.826590051004816 ABCA1 1 GO:0043984 histone H4-K16 acetylation 1/1115 20/18722 0.707326664859436 0.826590051004816 KMT2A 1 GO:0045844 positive regulation of striated muscle tissue development 1/1115 20/18722 0.707326664859436 0.826590051004816 CTNNB1 1 GO:0048636 positive regulation of muscle organ development 1/1115 20/18722 0.707326664859436 0.826590051004816 CTNNB1 1 GO:0048670 regulation of collateral sprouting 1/1115 20/18722 0.707326664859436 0.826590051004816 LRP1 1 GO:0051004 regulation of lipoprotein lipase activity 1/1115 20/18722 0.707326664859436 0.826590051004816 FURIN 1 GO:0051900 regulation of mitochondrial depolarization 1/1115 20/18722 0.707326664859436 0.826590051004816 IFI6 1 GO:0060231 mesenchymal to epithelial transition 1/1115 20/18722 0.707326664859436 0.826590051004816 CTNNB1 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/1115 20/18722 0.707326664859436 0.826590051004816 DHX36 1 GO:0070932 histone H3 deacetylation 1/1115 20/18722 0.707326664859436 0.826590051004816 ELK4 1 GO:0071625 vocalization behavior 1/1115 20/18722 0.707326664859436 0.826590051004816 GLI3 1 GO:0072087 renal vesicle development 1/1115 20/18722 0.707326664859436 0.826590051004816 CTNNB1 1 GO:0090370 negative regulation of cholesterol efflux 1/1115 20/18722 0.707326664859436 0.826590051004816 SREBF2 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/1115 20/18722 0.707326664859436 0.826590051004816 CALM1 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/1115 20/18722 0.707326664859436 0.826590051004816 MET 1 GO:2000678 negative regulation of transcription regulatory region DNA binding 1/1115 20/18722 0.707326664859436 0.826590051004816 TMSB4X 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/1115 20/18722 0.707326664859436 0.826590051004816 ZNF451 1 GO:0006164 purine nucleotide biosynthetic process 10/1115 191/18722 0.70737777543379 0.826590051004816 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/ACSL3/ELOVL1 10 GO:0015837 amine transport 5/1115 99/18722 0.709537516530621 0.828125390815156 ITGB1/SLC43A2/ARL6IP5/SYT7/RAB3GAP1 5 GO:0021549 cerebellum development 5/1115 99/18722 0.709537516530621 0.828125390815156 HSPA5/NCSTN/NAGLU/RERE/HNRNPD 5 GO:0007099 centriole replication 2/1115 41/18722 0.710242772905526 0.828125390815156 NPM1/CEP152 2 GO:0009167 purine ribonucleoside monophosphate metabolic process 2/1115 41/18722 0.710242772905526 0.828125390815156 DLG1/AK3 2 GO:0032733 positive regulation of interleukin-10 production 2/1115 41/18722 0.710242772905526 0.828125390815156 CD46/HMGB1 2 GO:0048634 regulation of muscle organ development 2/1115 41/18722 0.710242772905526 0.828125390815156 CTNNB1/YBX3 2 GO:0050691 regulation of defense response to virus by host 2/1115 41/18722 0.710242772905526 0.828125390815156 TRIM44/MAVS 2 GO:0060612 adipose tissue development 2/1115 41/18722 0.710242772905526 0.828125390815156 LRP5/ARID5B 2 GO:1900371 regulation of purine nucleotide biosynthetic process 2/1115 41/18722 0.710242772905526 0.828125390815156 ENO1/TMSB4X 2 GO:1902622 regulation of neutrophil migration 2/1115 41/18722 0.710242772905526 0.828125390815156 DPP4/CD74 2 GO:0007613 memory 6/1115 118/18722 0.711500464215745 0.829229639477813 LGMN/SLC6A4/SERPINF1/VLDLR/INSR/PAIP2 6 GO:0051282 regulation of sequestering of calcium ion 6/1115 118/18722 0.711500464215745 0.829229639477813 CALM1/ITPR2/MCOLN3/DMD/PKD2/IBTK 6 GO:0019748 secondary metabolic process 3/1115 61/18722 0.71222333895335 0.829601355138016 OPN3/APPL1/RAPGEF2 3 GO:0043966 histone H3 acetylation 3/1115 61/18722 0.71222333895335 0.829601355138016 ZNF451/JADE1/KMT2A 3 GO:0050866 negative regulation of cell activation 11/1115 210/18722 0.712285561332209 0.829601355138016 GRN/ANXA1/CD74/DLG5/DLG1/GLI3/C1QTNF1/HMGB1/RC3H1/ATM/ERBB2 11 GO:0007586 digestion 7/1115 137/18722 0.714378782826791 0.831857867287293 COPA/KCNN4/SLC22A5/IREB2/WNK1/F11R/LPCAT3 7 GO:0007204 positive regulation of cytosolic calcium ion concentration 17/1115 319/18722 0.716966962273761 0.832883588489847 LRP1/ITGAV/ATP2B4/GJA1/CALM1/P2RX4/ITPR2/MCOLN3/DMD/TRPV4/C1QTNF1/HMGB1/CAV1/S1PR3/EDNRB/PKD2/IBTK 17 GO:0006626 protein targeting to mitochondrion 5/1115 100/18722 0.717812181875661 0.832883588489847 LMAN1/FZD5/UBE2L3/NPEPPS/SREBF2 5 GO:0006753 nucleoside phosphate metabolic process 27/1115 497/18722 0.718317568664226 0.832883588489847 GAPDH/SLC26A2/LDHA/APP/ALDOA/ACSS1/TPST2/NCOR1/ENO1/DLG1/TPI1/ADCY7/CROT/TMSB4X/TECR/AK3/RRM2B/RAN/ACSL3/INSR/PDE10A/PDE7A/TDG/ELOVL1/FASN/GPAT4/RHOA 27 GO:2000243 positive regulation of reproductive process 4/1115 81/18722 0.718393691500288 0.832883588489847 AGO2/EDNRB/SMURF2/CTNNB1 4 GO:0006520 cellular amino acid metabolic process 15/1115 284/18722 0.721319109243138 0.832883588489847 GLDC/ATP2B4/SMS/BCAT1/IARS2/SERINC3/AASDH/SLC1A3/MTR/CLN3/ALDH18A1/SLC16A2/ALDH4A1/RIMKLB/BCAT2 15 GO:0002260 lymphocyte homeostasis 3/1115 62/18722 0.722559687894978 0.832883588489847 RPS6/CD74/RC3H1 3 GO:0010573 vascular endothelial growth factor production 3/1115 62/18722 0.722559687894978 0.832883588489847 ADGRG1/IL6ST/ISL1 3 GO:0032613 interleukin-10 production 3/1115 62/18722 0.722559687894978 0.832883588489847 CD46/CD47/HMGB1 3 GO:0032623 interleukin-2 production 3/1115 62/18722 0.722559687894978 0.832883588489847 ANXA1/RPS3/SPTBN1 3 GO:0032653 regulation of interleukin-10 production 3/1115 62/18722 0.722559687894978 0.832883588489847 CD46/CD47/HMGB1 3 GO:0032663 regulation of interleukin-2 production 3/1115 62/18722 0.722559687894978 0.832883588489847 ANXA1/RPS3/SPTBN1 3 GO:0046173 polyol biosynthetic process 3/1115 62/18722 0.722559687894978 0.832883588489847 ASAH1/SPTLC3/ISYNA1 3 GO:0045333 cellular respiration 12/1115 230/18722 0.722597748136898 0.832883588489847 COX6A1/PLEC/IL10RB/IREB2/CHCHD2/TRPV4/OPN3/IDH1/CAT/CYCS/RHOA/UQCRH 12 GO:0009154 purine ribonucleotide catabolic process 2/1115 42/18722 0.722725166568489 0.832883588489847 PDE10A/PDE7A 2 GO:0010677 negative regulation of cellular carbohydrate metabolic process 2/1115 42/18722 0.722725166568489 0.832883588489847 NCOR1/SOGA1 2 GO:0030808 regulation of nucleotide biosynthetic process 2/1115 42/18722 0.722725166568489 0.832883588489847 ENO1/TMSB4X 2 GO:0032467 positive regulation of cytokinesis 2/1115 42/18722 0.722725166568489 0.832883588489847 PKN2/RHOA 2 GO:0032691 negative regulation of interleukin-1 beta production 2/1115 42/18722 0.722725166568489 0.832883588489847 GSTP1/SERPINB1 2 GO:0033574 response to testosterone 2/1115 42/18722 0.722725166568489 0.832883588489847 XRN1/CFLAR 2 GO:0048489 synaptic vesicle transport 2/1115 42/18722 0.722725166568489 0.832883588489847 KIF5B/CTNNB1 2 GO:0046486 glycerolipid metabolic process 21/1115 392/18722 0.723933568663953 0.832883588489847 PGAP1/SERINC1/SLC44A2/SEL1L/CDS1/SMG1/SERINC3/GPAA1/SLC44A1/CLN3/OSBPL8/CAV1/ACSL3/PISD/LPCAT3/AGPAT1/CAT/ATM/SERINC2/GPAT4/ETNK1 21 GO:0001502 cartilage condensation 1/1115 21/18722 0.724775641903695 0.832883588489847 MAPK14 1 GO:0006067 ethanol metabolic process 1/1115 21/18722 0.724775641903695 0.832883588489847 ACSS1 1 GO:0006244 pyrimidine nucleotide catabolic process 1/1115 21/18722 0.724775641903695 0.832883588489847 TDG 1 GO:0006925 inflammatory cell apoptotic process 1/1115 21/18722 0.724775641903695 0.832883588489847 ANXA1 1 GO:0009067 aspartate family amino acid biosynthetic process 1/1115 21/18722 0.724775641903695 0.832883588489847 MTR 1 GO:0009070 serine family amino acid biosynthetic process 1/1115 21/18722 0.724775641903695 0.832883588489847 SERINC3 1 GO:0010766 negative regulation of sodium ion transport 1/1115 21/18722 0.724775641903695 0.832883588489847 WNK1 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/1115 21/18722 0.724775641903695 0.832883588489847 ANXA2 1 GO:0016075 rRNA catabolic process 1/1115 21/18722 0.724775641903695 0.832883588489847 XRN1 1 GO:0023019 signal transduction involved in regulation of gene expression 1/1115 21/18722 0.724775641903695 0.832883588489847 SMAD2 1 GO:0030449 regulation of complement activation 1/1115 21/18722 0.724775641903695 0.832883588489847 CD46 1 GO:0030502 negative regulation of bone mineralization 1/1115 21/18722 0.724775641903695 0.832883588489847 LTBP3 1 GO:0032482 Rab protein signal transduction 1/1115 21/18722 0.724775641903695 0.832883588489847 DENND4C 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/1115 21/18722 0.724775641903695 0.832883588489847 FERMT1 1 GO:0035455 response to interferon-alpha 1/1115 21/18722 0.724775641903695 0.832883588489847 TPR 1 GO:0035813 regulation of renal sodium excretion 1/1115 21/18722 0.724775641903695 0.832883588489847 EDNRB 1 GO:0043576 regulation of respiratory gaseous exchange 1/1115 21/18722 0.724775641903695 0.832883588489847 SLC5A3 1 GO:0044241 lipid digestion 1/1115 21/18722 0.724775641903695 0.832883588489847 LPCAT3 1 GO:0044342 type B pancreatic cell proliferation 1/1115 21/18722 0.724775641903695 0.832883588489847 SERPINB1 1 GO:0044766 multi-organism transport 1/1115 21/18722 0.724775641903695 0.832883588489847 CAV1 1 GO:0046597 negative regulation of viral entry into host cell 1/1115 21/18722 0.724775641903695 0.832883588489847 LY6E 1 GO:0046599 regulation of centriole replication 1/1115 21/18722 0.724775641903695 0.832883588489847 NPM1 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/1115 21/18722 0.724775641903695 0.832883588489847 DAG1 1 GO:0050802 circadian sleep/wake cycle, sleep 1/1115 21/18722 0.724775641903695 0.832883588489847 ADRB1 1 GO:0050849 negative regulation of calcium-mediated signaling 1/1115 21/18722 0.724775641903695 0.832883588489847 ATP2B4 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/1115 21/18722 0.724775641903695 0.832883588489847 PIAS1 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/1115 21/18722 0.724775641903695 0.832883588489847 GSTP1 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/1115 21/18722 0.724775641903695 0.832883588489847 GSTP1 1 GO:0060972 left/right pattern formation 1/1115 21/18722 0.724775641903695 0.832883588489847 AHI1 1 GO:0070584 mitochondrion morphogenesis 1/1115 21/18722 0.724775641903695 0.832883588489847 PLEC 1 GO:0098719 sodium ion import across plasma membrane 1/1115 21/18722 0.724775641903695 0.832883588489847 SLC9A1 1 GO:0098856 intestinal lipid absorption 1/1115 21/18722 0.724775641903695 0.832883588489847 LPCAT3 1 GO:0150146 cell junction disassembly 1/1115 21/18722 0.724775641903695 0.832883588489847 TGFBR1 1 GO:1900118 negative regulation of execution phase of apoptosis 1/1115 21/18722 0.724775641903695 0.832883588489847 FZD3 1 GO:1901863 positive regulation of muscle tissue development 1/1115 21/18722 0.724775641903695 0.832883588489847 CTNNB1 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/1115 21/18722 0.724775641903695 0.832883588489847 ANK3 1 GO:1902579 multi-organism localization 1/1115 21/18722 0.724775641903695 0.832883588489847 CAV1 1 GO:1902644 tertiary alcohol metabolic process 1/1115 21/18722 0.724775641903695 0.832883588489847 REST 1 GO:1903429 regulation of cell maturation 1/1115 21/18722 0.724775641903695 0.832883588489847 EDNRB 1 GO:1905209 positive regulation of cardiocyte differentiation 1/1115 21/18722 0.724775641903695 0.832883588489847 DHX36 1 GO:0002285 lymphocyte activation involved in immune response 10/1115 194/18722 0.725370422562772 0.833387709503473 CD46/ANXA1/RPS6/CD74/RIF1/TFRC/FOXP1/HMGB1/ITFG2/RC3H1 10 GO:0051963 regulation of synapse assembly 5/1115 101/18722 0.725917846519762 0.833837216559598 APP/DLG5/CLSTN1/PPP1R9A/TPBG 5 GO:0046889 positive regulation of lipid biosynthetic process 4/1115 82/18722 0.727334028045941 0.835104596932748 ANXA1/CD74/SORBS1/ACSL3 4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 4/1115 82/18722 0.727334028045941 0.835104596932748 DICER1/RPS21/AGO2/SND1 4 GO:0050728 negative regulation of inflammatory response 9/1115 176/18722 0.727663661982315 0.835303438254908 GRN/ASH1L/SERPINF1/FURIN/GSTP1/MAPK14/LPCAT3/ISL1/SOD1 9 GO:1901605 alpha-amino acid metabolic process 10/1115 195/18722 0.731204123433172 0.83918719153261 GLDC/ATP2B4/SMS/SERINC3/MTR/CLN3/ALDH18A1/ALDH4A1/RIMKLB/BCAT2 10 GO:0046902 regulation of mitochondrial membrane permeability 3/1115 63/18722 0.732604078370252 0.840613190289872 SLC9A1/SLC35F6/HSPA1A 3 GO:0071466 cellular response to xenobiotic stimulus 9/1115 177/18722 0.73374552207831 0.84072674336431 EGFR/ABCA1/GSTP1/TFRC/HSPA5/NCEH1/PPP1R12A/TLR3/REST 9 GO:0010522 regulation of calcium ion transport into cytosol 5/1115 102/18722 0.733854660820359 0.84072674336431 CALM1/P2RX4/DMD/CAV1/PKD2 5 GO:0062014 negative regulation of small molecule metabolic process 5/1115 102/18722 0.733854660820359 0.84072674336431 ATP2B4/NCOR1/SOGA1/REST/SOD1 5 GO:0002861 regulation of inflammatory response to antigenic stimulus 2/1115 43/18722 0.734750137579672 0.84072674336431 FURIN/MAPK14 2 GO:0034142 toll-like receptor 4 signaling pathway 2/1115 43/18722 0.734750137579672 0.84072674336431 HMGB1/APPL1 2 GO:0042088 T-helper 1 type immune response 2/1115 43/18722 0.734750137579672 0.84072674336431 ANXA1/HMGB1 2 GO:0042181 ketone biosynthetic process 2/1115 43/18722 0.734750137579672 0.84072674336431 TPI1/REST 2 GO:0045494 photoreceptor cell maintenance 2/1115 43/18722 0.734750137579672 0.84072674336431 SLC2A1/CLCN3 2 GO:0090278 negative regulation of peptide hormone secretion 2/1115 43/18722 0.734750137579672 0.84072674336431 PPP3CA/REST 2 GO:0098815 modulation of excitatory postsynaptic potential 2/1115 43/18722 0.734750137579672 0.84072674336431 APP/S1PR2 2 GO:0098927 vesicle-mediated transport between endosomal compartments 2/1115 43/18722 0.734750137579672 0.84072674336431 EEA1/HOOK2 2 GO:0140353 lipid export from cell 2/1115 43/18722 0.734750137579672 0.84072674336431 P2RX4/C1QTNF1 2 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/1115 43/18722 0.734750137579672 0.84072674336431 IFI6/HSPA1A 2 GO:0046165 alcohol biosynthetic process 7/1115 140/18722 0.735112902264396 0.840961599569233 ASAH1/SPTLC3/DHCR24/LPCAT3/ISYNA1/REST/SOD1 7 GO:0043367 CD4-positive, alpha-beta T cell differentiation 4/1115 83/18722 0.736060764520731 0.841865557364221 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0072329 monocarboxylic acid catabolic process 6/1115 122/18722 0.741011510901364 0.842851498743834 SLC27A2/CROT/ECHDC2/CPT2/ABCD3/ACOX1 6 GO:0002220 innate immune response activating cell surface receptor signaling pathway 1/1115 22/18722 0.741185200712175 0.842851498743834 CREBBP 1 GO:0002320 lymphoid progenitor cell differentiation 1/1115 22/18722 0.741185200712175 0.842851498743834 PRKDC 1 GO:0006359 regulation of transcription by RNA polymerase III 1/1115 22/18722 0.741185200712175 0.842851498743834 DHX36 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/1115 22/18722 0.741185200712175 0.842851498743834 FOLR1 1 GO:0009190 cyclic nucleotide biosynthetic process 1/1115 22/18722 0.741185200712175 0.842851498743834 ADCY7 1 GO:0019400 alditol metabolic process 1/1115 22/18722 0.741185200712175 0.842851498743834 TPI1 1 GO:0021904 dorsal/ventral neural tube patterning 1/1115 22/18722 0.741185200712175 0.842851498743834 GLI3 1 GO:0030277 maintenance of gastrointestinal epithelium 1/1115 22/18722 0.741185200712175 0.842851498743834 SLC22A5 1 GO:0031061 negative regulation of histone methylation 1/1115 22/18722 0.741185200712175 0.842851498743834 JARID2 1 GO:0035357 peroxisome proliferator activated receptor signaling pathway 1/1115 22/18722 0.741185200712175 0.842851498743834 ACTN4 1 GO:0035561 regulation of chromatin binding 1/1115 22/18722 0.741185200712175 0.842851498743834 PPP3CA 1 GO:0035809 regulation of urine volume 1/1115 22/18722 0.741185200712175 0.842851498743834 EDNRB 1 GO:0036120 cellular response to platelet-derived growth factor stimulus 1/1115 22/18722 0.741185200712175 0.842851498743834 PDGFD 1 GO:0042749 regulation of circadian sleep/wake cycle 1/1115 22/18722 0.741185200712175 0.842851498743834 ADRB1 1 GO:0043574 peroxisomal transport 1/1115 22/18722 0.741185200712175 0.842851498743834 ABCD3 1 GO:0045624 positive regulation of T-helper cell differentiation 1/1115 22/18722 0.741185200712175 0.842851498743834 ANXA1 1 GO:0045663 positive regulation of myoblast differentiation 1/1115 22/18722 0.741185200712175 0.842851498743834 MAPK14 1 GO:0048169 regulation of long-term neuronal synaptic plasticity 1/1115 22/18722 0.741185200712175 0.842851498743834 APP 1 GO:0052652 cyclic purine nucleotide metabolic process 1/1115 22/18722 0.741185200712175 0.842851498743834 ADCY7 1 GO:0071467 cellular response to pH 1/1115 22/18722 0.741185200712175 0.842851498743834 SLC9A1 1 GO:0072574 hepatocyte proliferation 1/1115 22/18722 0.741185200712175 0.842851498743834 CFLAR 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/1115 22/18722 0.741185200712175 0.842851498743834 CFLAR 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/1115 22/18722 0.741185200712175 0.842851498743834 ANK3 1 GO:0097164 ammonium ion metabolic process 1/1115 22/18722 0.741185200712175 0.842851498743834 SLC44A1 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/1115 22/18722 0.741185200712175 0.842851498743834 NCOR1 1 GO:1901032 negative regulation of response to reactive oxygen species 1/1115 22/18722 0.741185200712175 0.842851498743834 MET 1 GO:0030593 neutrophil chemotaxis 5/1115 103/18722 0.741622975051903 0.843169732496191 CSF3R/DPP4/CD74/PPIA/VAV3 5 GO:0016126 sterol biosynthetic process 3/1115 64/18722 0.742359562199694 0.843468334237958 DHCR24/LPCAT3/SOD1 3 GO:0030858 positive regulation of epithelial cell differentiation 3/1115 64/18722 0.742359562199694 0.843468334237958 NCOA3/AHI1/CTNNB1 3 GO:0046888 negative regulation of hormone secretion 3/1115 64/18722 0.742359562199694 0.843468334237958 GJA1/PPP3CA/REST 3 GO:0009953 dorsal/ventral pattern formation 4/1115 84/18722 0.744575079710119 0.84580560650475 GLI3/SMAD2/BMPR1A/CTNNB1 4 GO:0006378 mRNA polyadenylation 2/1115 44/18722 0.746327842047442 0.846715756202994 APP/AHCYL1 2 GO:0009126 purine nucleoside monophosphate metabolic process 2/1115 44/18722 0.746327842047442 0.846715756202994 DLG1/AK3 2 GO:0009262 deoxyribonucleotide metabolic process 2/1115 44/18722 0.746327842047442 0.846715756202994 RRM2B/TDG 2 GO:0031295 T cell costimulation 2/1115 44/18722 0.746327842047442 0.846715756202994 DPP4/CAV1 2 GO:0042269 regulation of natural killer cell mediated cytotoxicity 2/1115 44/18722 0.746327842047442 0.846715756202994 SERPINB9/CADM1 2 GO:0048066 developmental pigmentation 2/1115 44/18722 0.746327842047442 0.846715756202994 GLI3/EDNRB 2 GO:0002699 positive regulation of immune effector process 12/1115 235/18722 0.748957495840303 0.849518604268404 CD46/ANXA1/CD74/RIF1/TFRC/FZD5/DHX36/SEMA7A/ANKRD17/MAVS/MR1/CADM1 12 GO:0046634 regulation of alpha-beta T cell activation 5/1115 104/18722 0.749223328785084 0.849606341873324 ANXA1/GLI3/HMGB1/RC3H1/RHOA 5 GO:0048285 organelle fission 26/1115 488/18722 0.750602238387994 0.849606341873324 LRP5/NIPBL/ATRX/BMP7/TPR/RPL24/EML4/PHIP/TOP2B/KPNB1/PDS5B/INF2/RANBP1/RAN/ZNF207/SLC2A8/OBSL1/INSR/CDK13/ATM/UBE2C/NUSAP1/CDC20/HSPA1A/MLH3/RHOA 26 GO:0051310 metaphase plate congression 3/1115 65/18722 0.751829565582632 0.849606341873324 EML4/DYNC1H1/KPNB1 3 GO:0072577 endothelial cell apoptotic process 3/1115 65/18722 0.751829565582632 0.849606341873324 ANO6/PRKCI/BMPR2 3 GO:0009142 nucleoside triphosphate biosynthetic process 4/1115 85/18722 0.752878409158683 0.849606341873324 ALDOA/ENO1/TMSB4X/AK3 4 GO:0097194 execution phase of apoptosis 4/1115 85/18722 0.752878409158683 0.849606341873324 DICER1/TAOK1/CFLAR/FZD3 4 GO:0001909 leukocyte mediated cytotoxicity 6/1115 124/18722 0.754930913708246 0.849606341873324 PRDX1/CTSC/KIF5B/SERPINB9/MR1/CADM1 6 GO:0007368 determination of left/right symmetry 6/1115 124/18722 0.754930913708246 0.849606341873324 GALNT11/FOLR1/MIB1/SMAD2/AHI1/PKD2 6 GO:0042445 hormone metabolic process 11/1115 218/18722 0.756268219825689 0.849606341873324 MME/CTSB/ENPEP/FURIN/TCF7L2/PCSK7/GCNT4/ATP1A1/SLC16A2/REST/DHRS3 11 GO:0001759 organ induction 1/1115 23/18722 0.756617206124256 0.849606341873324 CTNNB1 1 GO:0001919 regulation of receptor recycling 1/1115 23/18722 0.756617206124256 0.849606341873324 ANXA2 1 GO:0002082 regulation of oxidative phosphorylation 1/1115 23/18722 0.756617206124256 0.849606341873324 RHOA 1 GO:0002363 alpha-beta T cell lineage commitment 1/1115 23/18722 0.756617206124256 0.849606341873324 RHOA 1 GO:0002758 innate immune response-activating signal transduction 1/1115 23/18722 0.756617206124256 0.849606341873324 CREBBP 1 GO:0003323 type B pancreatic cell development 1/1115 23/18722 0.756617206124256 0.849606341873324 CDK6 1 GO:0007130 synaptonemal complex assembly 1/1115 23/18722 0.756617206124256 0.849606341873324 MLH3 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/1115 23/18722 0.756617206124256 0.849606341873324 LRP1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/1115 23/18722 0.756617206124256 0.849606341873324 GSTP1 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/1115 23/18722 0.756617206124256 0.849606341873324 CLDN4 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/1115 23/18722 0.756617206124256 0.849606341873324 THOC2 1 GO:0021544 subpallium development 1/1115 23/18722 0.756617206124256 0.849606341873324 GLI3 1 GO:0021895 cerebral cortex neuron differentiation 1/1115 23/18722 0.756617206124256 0.849606341873324 C21orf91 1 GO:0030194 positive regulation of blood coagulation 1/1115 23/18722 0.756617206124256 0.849606341873324 ANO6 1 GO:0034695 response to prostaglandin E 1/1115 23/18722 0.756617206124256 0.849606341873324 TGFBR3 1 GO:0035640 exploration behavior 1/1115 23/18722 0.756617206124256 0.849606341873324 DPP4 1 GO:0035929 steroid hormone secretion 1/1115 23/18722 0.756617206124256 0.849606341873324 C1QTNF1 1 GO:0036119 response to platelet-derived growth factor 1/1115 23/18722 0.756617206124256 0.849606341873324 PDGFD 1 GO:0045662 negative regulation of myoblast differentiation 1/1115 23/18722 0.756617206124256 0.849606341873324 MBNL3 1 GO:0045932 negative regulation of muscle contraction 1/1115 23/18722 0.756617206124256 0.849606341873324 SOD1 1 GO:0045980 negative regulation of nucleotide metabolic process 1/1115 23/18722 0.756617206124256 0.849606341873324 NCOR1 1 GO:0051349 positive regulation of lyase activity 1/1115 23/18722 0.756617206124256 0.849606341873324 NF1 1 GO:0051383 kinetochore organization 1/1115 23/18722 0.756617206124256 0.849606341873324 SENP6 1 GO:0051457 maintenance of protein location in nucleus 1/1115 23/18722 0.756617206124256 0.849606341873324 SKP1 1 GO:0051882 mitochondrial depolarization 1/1115 23/18722 0.756617206124256 0.849606341873324 IFI6 1 GO:0051904 pigment granule transport 1/1115 23/18722 0.756617206124256 0.849606341873324 MYO7A 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/1115 23/18722 0.756617206124256 0.849606341873324 MAPK14 1 GO:0060396 growth hormone receptor signaling pathway 1/1115 23/18722 0.756617206124256 0.849606341873324 CSH1 1 GO:0060575 intestinal epithelial cell differentiation 1/1115 23/18722 0.756617206124256 0.849606341873324 IL6ST 1 GO:0071218 cellular response to misfolded protein 1/1115 23/18722 0.756617206124256 0.849606341873324 DNAJB14 1 GO:0071305 cellular response to vitamin D 1/1115 23/18722 0.756617206124256 0.849606341873324 ATP2B1 1 GO:0071514 genetic imprinting 1/1115 23/18722 0.756617206124256 0.849606341873324 DNMT3A 1 GO:0072576 liver morphogenesis 1/1115 23/18722 0.756617206124256 0.849606341873324 CFLAR 1 GO:0090103 cochlea morphogenesis 1/1115 23/18722 0.756617206124256 0.849606341873324 PTK7 1 GO:1900048 positive regulation of hemostasis 1/1115 23/18722 0.756617206124256 0.849606341873324 ANO6 1 GO:1902410 mitotic cytokinetic process 1/1115 23/18722 0.756617206124256 0.849606341873324 RHOA 1 GO:1903306 negative regulation of regulated secretory pathway 1/1115 23/18722 0.756617206124256 0.849606341873324 REST 1 GO:0022602 ovulation cycle process 2/1115 45/18722 0.757468849469381 0.849606341873324 ADAMTS1/HSPA5 2 GO:0031670 cellular response to nutrient 2/1115 45/18722 0.757468849469381 0.849606341873324 ATP2B1/FOLR1 2 GO:0043038 amino acid activation 2/1115 45/18722 0.757468849469381 0.849606341873324 IARS2/AASDH 2 GO:0043631 RNA polyadenylation 2/1115 45/18722 0.757468849469381 0.849606341873324 APP/AHCYL1 2 GO:0048599 oocyte development 2/1115 45/18722 0.757468849469381 0.849606341873324 ZFX/CTNNB1 2 GO:0098534 centriole assembly 2/1115 45/18722 0.757468849469381 0.849606341873324 NPM1/CEP152 2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 2/1115 45/18722 0.757468849469381 0.849606341873324 SLC35F6/HSPA1A 2 GO:1901617 organic hydroxy compound biosynthetic process 12/1115 237/18722 0.759018137497815 0.851113063668954 SLC27A2/ASAH1/SPTLC3/DHCR24/ABCD3/OPN3/APPL1/LPCAT3/ISYNA1/REST/RAPGEF2/SOD1 12 GO:0072522 purine-containing compound biosynthetic process 10/1115 200/18722 0.759131000035879 0.851113063668954 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/ACSL3/ELOVL1 10 GO:0046626 regulation of insulin receptor signaling pathway 3/1115 66/18722 0.76101785153002 0.852954960908154 KANK1/SORBS1/OSBPL8 3 GO:0010324 membrane invagination 7/1115 144/18722 0.761093357139248 0.852954960908154 ABCA1/ANO6/SNX18/CLCN3/RHOBTB1/RAB31/RHOA 7 GO:0006473 protein acetylation 10/1115 201/18722 0.76446709188608 0.856294142467271 NCOA3/MORF4L2/RPS6KA5/TAOK1/ZNF451/JADE1/KMT2A/ISL1/CREBBP/MORF4L1 10 GO:0006195 purine nucleotide catabolic process 2/1115 46/18722 0.768184057584067 0.856294142467271 PDE10A/PDE7A 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/1115 46/18722 0.768184057584067 0.856294142467271 TENM3/CADM1 2 GO:0031018 endocrine pancreas development 2/1115 46/18722 0.768184057584067 0.856294142467271 ANXA1/CDK6 2 GO:0031294 lymphocyte costimulation 2/1115 46/18722 0.768184057584067 0.856294142467271 DPP4/CAV1 2 GO:0031648 protein destabilization 2/1115 46/18722 0.768184057584067 0.856294142467271 PRKDC/CREBBP 2 GO:0034198 cellular response to amino acid starvation 2/1115 46/18722 0.768184057584067 0.856294142467271 SLC38A2/ITFG2 2 GO:0046839 phospholipid dephosphorylation 2/1115 46/18722 0.768184057584067 0.856294142467271 PLPP3/SGPP1 2 GO:0016101 diterpenoid metabolic process 4/1115 87/18722 0.768859027033324 0.856294142467271 EGFR/LRP2/LRP1/DHRS3 4 GO:1901606 alpha-amino acid catabolic process 4/1115 87/18722 0.768859027033324 0.856294142467271 GLDC/ATP2B4/ALDH4A1/BCAT2 4 GO:0009583 detection of light stimulus 3/1115 67/18722 0.769928484379057 0.856294142467271 CDS1/GNAQ/OPN3 3 GO:0016445 somatic diversification of immunoglobulins 3/1115 67/18722 0.769928484379057 0.856294142467271 PRKDC/RIF1/TFRC 3 GO:0046635 positive regulation of alpha-beta T cell activation 3/1115 67/18722 0.769928484379057 0.856294142467271 ANXA1/GLI3/RHOA 3 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 3/1115 67/18722 0.769928484379057 0.856294142467271 ANXA1/HMGB1/RC3H1 3 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/1115 24/18722 0.771129843975021 0.856294142467271 RPS21 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/1115 24/18722 0.771129843975021 0.856294142467271 SERPINB9 1 GO:0002726 positive regulation of T cell cytokine production 1/1115 24/18722 0.771129843975021 0.856294142467271 FZD5 1 GO:0006213 pyrimidine nucleoside metabolic process 1/1115 24/18722 0.771129843975021 0.856294142467271 ERH 1 GO:0006817 phosphate ion transport 1/1115 24/18722 0.771129843975021 0.856294142467271 ANKH 1 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 1/1115 24/18722 0.771129843975021 0.856294142467271 TDG 1 GO:0022410 circadian sleep/wake cycle process 1/1115 24/18722 0.771129843975021 0.856294142467271 ADRB1 1 GO:0032528 microvillus organization 1/1115 24/18722 0.771129843975021 0.856294142467271 RAPGEF2 1 GO:0035458 cellular response to interferon-beta 1/1115 24/18722 0.771129843975021 0.856294142467271 TLR3 1 GO:0038095 Fc-epsilon receptor signaling pathway 1/1115 24/18722 0.771129843975021 0.856294142467271 VAV3 1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1/1115 24/18722 0.771129843975021 0.856294142467271 GPC1 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/1115 24/18722 0.771129843975021 0.856294142467271 PHIP 1 GO:0044062 regulation of excretion 1/1115 24/18722 0.771129843975021 0.856294142467271 EDNRB 1 GO:0050687 negative regulation of defense response to virus 1/1115 24/18722 0.771129843975021 0.856294142467271 PCBP2 1 GO:0050820 positive regulation of coagulation 1/1115 24/18722 0.771129843975021 0.856294142467271 ANO6 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/1115 24/18722 0.771129843975021 0.856294142467271 CALM1 1 GO:0051905 establishment of pigment granule localization 1/1115 24/18722 0.771129843975021 0.856294142467271 MYO7A 1 GO:0051923 sulfation 1/1115 24/18722 0.771129843975021 0.856294142467271 TPST2 1 GO:0070129 regulation of mitochondrial translation 1/1115 24/18722 0.771129843975021 0.856294142467271 LRPPRC 1 GO:0070841 inclusion body assembly 1/1115 24/18722 0.771129843975021 0.856294142467271 HSPA1A 1 GO:0071294 cellular response to zinc ion 1/1115 24/18722 0.771129843975021 0.856294142467271 P2RX4 1 GO:0071378 cellular response to growth hormone stimulus 1/1115 24/18722 0.771129843975021 0.856294142467271 CSH1 1 GO:0071577 zinc ion transmembrane transport 1/1115 24/18722 0.771129843975021 0.856294142467271 SLC39A10 1 GO:0090023 positive regulation of neutrophil chemotaxis 1/1115 24/18722 0.771129843975021 0.856294142467271 CD74 1 GO:0098743 cell aggregation 1/1115 24/18722 0.771129843975021 0.856294142467271 MAPK14 1 GO:0120255 olefinic compound biosynthetic process 1/1115 24/18722 0.771129843975021 0.856294142467271 REST 1 GO:1901984 negative regulation of protein acetylation 1/1115 24/18722 0.771129843975021 0.856294142467271 ZNF451 1 GO:1903861 positive regulation of dendrite extension 1/1115 24/18722 0.771129843975021 0.856294142467271 ITSN2 1 GO:2000310 regulation of NMDA receptor activity 1/1115 24/18722 0.771129843975021 0.856294142467271 APP 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/1115 24/18722 0.771129843975021 0.856294142467271 CTNNB1 1 GO:0032635 interleukin-6 production 8/1115 165/18722 0.773150905789498 0.858181431602937 APP/CD74/CD47/TRPV4/HMGB1/TLR3/ISL1/MAVS 8 GO:0032675 regulation of interleukin-6 production 8/1115 165/18722 0.773150905789498 0.858181431602937 APP/CD74/CD47/TRPV4/HMGB1/TLR3/ISL1/MAVS 8 GO:0022037 metencephalon development 5/1115 108/18722 0.777961976443972 0.862936015497012 HSPA5/NCSTN/NAGLU/RERE/HNRNPD 5 GO:0006998 nuclear envelope organization 2/1115 47/18722 0.778484615882822 0.862936015497012 TMEM170A/TMEM43 2 GO:0009261 ribonucleotide catabolic process 2/1115 47/18722 0.778484615882822 0.862936015497012 PDE10A/PDE7A 2 GO:0010712 regulation of collagen metabolic process 2/1115 47/18722 0.778484615882822 0.862936015497012 ITGB1/SUCO 2 GO:0016073 snRNA metabolic process 2/1115 47/18722 0.778484615882822 0.862936015497012 INTS6/INTS1 2 GO:1900744 regulation of p38MAPK cascade 2/1115 47/18722 0.778484615882822 0.862936015497012 DLG1/EMC10 2 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 3/1115 68/18722 0.778565796338098 0.862936015497012 ALDOA/ENO1/TMSB4X 3 GO:1903531 negative regulation of secretion by cell 7/1115 147/18722 0.779334557463757 0.863608800809257 ANXA1/GJA1/PPP1R9A/FRMD4A/PPP3CA/REST/RHBDF1 7 GO:0034728 nucleosome organization 8/1115 167/18722 0.784315636272554 0.867480100648111 NPM1/ATRX/BPTF/ARID1A/RSF1/SMARCC1/SETD2/SHPRH 8 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/1115 25/18722 0.78477783969477 0.867480100648111 AK3 1 GO:0016540 protein autoprocessing 1/1115 25/18722 0.78477783969477 0.867480100648111 PISD 1 GO:0035902 response to immobilization stress 1/1115 25/18722 0.78477783969477 0.867480100648111 FOXO4 1 GO:0042730 fibrinolysis 1/1115 25/18722 0.78477783969477 0.867480100648111 ANXA2 1 GO:0046339 diacylglycerol metabolic process 1/1115 25/18722 0.78477783969477 0.867480100648111 GPAT4 1 GO:0051291 protein heterooligomerization 1/1115 25/18722 0.78477783969477 0.867480100648111 PKD2 1 GO:0051307 meiotic chromosome separation 1/1115 25/18722 0.78477783969477 0.867480100648111 TOP2B 1 GO:0051788 response to misfolded protein 1/1115 25/18722 0.78477783969477 0.867480100648111 DNAJB14 1 GO:0090312 positive regulation of protein deacetylation 1/1115 25/18722 0.78477783969477 0.867480100648111 NIPBL 1 GO:1905563 negative regulation of vascular endothelial cell proliferation 1/1115 25/18722 0.78477783969477 0.867480100648111 FLT1 1 GO:2000316 regulation of T-helper 17 type immune response 1/1115 25/18722 0.78477783969477 0.867480100648111 RC3H1 1 GO:0097530 granulocyte migration 7/1115 148/18722 0.78518009649923 0.867745091121795 CSF3R/ANXA1/DPP4/CD74/PPIA/TRPV4/VAV3 7 GO:0009145 purine nucleoside triphosphate biosynthetic process 3/1115 69/18722 0.786934356005384 0.868964328172232 ALDOA/ENO1/TMSB4X 3 GO:0050688 regulation of defense response to virus 3/1115 69/18722 0.786934356005384 0.868964328172232 PCBP2/TRIM44/MAVS 3 GO:0050805 negative regulation of synaptic transmission 3/1115 69/18722 0.786934356005384 0.868964328172232 SLC6A4/PPP1R9A/S1PR2 3 GO:0051966 regulation of synaptic transmission, glutamatergic 3/1115 69/18722 0.786934356005384 0.868964328172232 EGFR/RAB3GAP1/CLN3 3 GO:0002715 regulation of natural killer cell mediated immunity 2/1115 48/18722 0.788381857053427 0.869843094608028 SERPINB9/CADM1 2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 2/1115 48/18722 0.788381857053427 0.869843094608028 BOD1L1/ATRX 2 GO:0090311 regulation of protein deacetylation 2/1115 48/18722 0.788381857053427 0.869843094608028 NIPBL/KDM5A 2 GO:1902003 regulation of amyloid-beta formation 2/1115 48/18722 0.788381857053427 0.869843094608028 RTN4/ROCK1 2 GO:0002706 regulation of lymphocyte mediated immunity 8/1115 168/18722 0.789744132846159 0.870986144446529 CD46/RIF1/TFRC/FZD5/HMGB1/SERPINB9/MR1/CADM1 8 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/1115 168/18722 0.789744132846159 0.870986144446529 CD46/ANXA1/RIF1/TFRC/FZD5/HMGB1/RC3H1/MR1 8 GO:0002703 regulation of leukocyte mediated immunity 11/1115 226/18722 0.795423737535654 0.874906541654394 CD46/RIF1/TFRC/FZD5/DHX36/HMGB1/TLR3/MAVS/SERPINB9/MR1/CADM1 11 GO:0001963 synaptic transmission, dopaminergic 1/1115 26/18722 0.797612663930761 0.874906541654394 SLC6A4 1 GO:0006706 steroid catabolic process 1/1115 26/18722 0.797612663930761 0.874906541654394 STS 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/1115 26/18722 0.797612663930761 0.874906541654394 GABRE 1 GO:0045026 plasma membrane fusion 1/1115 26/18722 0.797612663930761 0.874906541654394 FOLR1 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/1115 26/18722 0.797612663930761 0.874906541654394 CADM1 1 GO:0048499 synaptic vesicle membrane organization 1/1115 26/18722 0.797612663930761 0.874906541654394 SYNGR2 1 GO:0051875 pigment granule localization 1/1115 26/18722 0.797612663930761 0.874906541654394 MYO7A 1 GO:0060219 camera-type eye photoreceptor cell differentiation 1/1115 26/18722 0.797612663930761 0.874906541654394 NAGLU 1 GO:0070102 interleukin-6-mediated signaling pathway 1/1115 26/18722 0.797612663930761 0.874906541654394 IL6ST 1 GO:0070193 synaptonemal complex organization 1/1115 26/18722 0.797612663930761 0.874906541654394 MLH3 1 GO:0071425 hematopoietic stem cell proliferation 1/1115 26/18722 0.797612663930761 0.874906541654394 N4BP2L2 1 GO:0099637 neurotransmitter receptor transport 1/1115 26/18722 0.797612663930761 0.874906541654394 CLSTN1 1 GO:1900017 positive regulation of cytokine production involved in inflammatory response 1/1115 26/18722 0.797612663930761 0.874906541654394 APPL1 1 GO:1904861 excitatory synapse assembly 1/1115 26/18722 0.797612663930761 0.874906541654394 PLXNB2 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/1115 26/18722 0.797612663930761 0.874906541654394 NFATC3 1 GO:0001913 T cell mediated cytotoxicity 2/1115 49/18722 0.797887235683694 0.874906541654394 CTSC/MR1 2 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 2/1115 49/18722 0.797887235683694 0.874906541654394 RIF1/TFRC 2 GO:0002208 somatic diversification of immunoglobulins involved in immune response 2/1115 49/18722 0.797887235683694 0.874906541654394 RIF1/TFRC 2 GO:0006953 acute-phase response 2/1115 49/18722 0.797887235683694 0.874906541654394 FN1/EDNRB 2 GO:0009066 aspartate family amino acid metabolic process 2/1115 49/18722 0.797887235683694 0.874906541654394 SMS/MTR 2 GO:0021515 cell differentiation in spinal cord 2/1115 49/18722 0.797887235683694 0.874906541654394 GLI3/ISL1 2 GO:0032692 negative regulation of interleukin-1 production 2/1115 49/18722 0.797887235683694 0.874906541654394 GSTP1/SERPINB1 2 GO:0042304 regulation of fatty acid biosynthetic process 2/1115 49/18722 0.797887235683694 0.874906541654394 ANXA1/CD74 2 GO:0045190 isotype switching 2/1115 49/18722 0.797887235683694 0.874906541654394 RIF1/TFRC 2 GO:0060986 endocrine hormone secretion 2/1115 49/18722 0.797887235683694 0.874906541654394 GJA1/C1QTNF1 2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 2/1115 49/18722 0.797887235683694 0.874906541654394 CFLAR/FEM1B 2 GO:1990928 response to amino acid starvation 2/1115 49/18722 0.797887235683694 0.874906541654394 SLC38A2/ITFG2 2 GO:0019935 cyclic-nucleotide-mediated signaling 4/1115 91/18722 0.79837592186544 0.87526263795474 EDNRB/PDE10A/PDE7A/RAPGEF2 4 GO:0009060 aerobic respiration 9/1115 189/18722 0.799543800840034 0.876363036888717 COX6A1/IREB2/CHCHD2/TRPV4/IDH1/CAT/CYCS/RHOA/UQCRH 9 GO:0001818 negative regulation of cytokine production 18/1115 357/18722 0.799797873944101 0.876461586409596 ATP2B1/ANXA1/LGR4/DICER1/RNF128/FURIN/HSP90AB1/RPS6KA5/FN1/GSTP1/ADCY7/CHID1/TMSB4X/HMGB1/TSKU/SUZ12/REL/SERPINB1 18 GO:0071216 cellular response to biotic stimulus 12/1115 246/18722 0.800856052728645 0.877441096966599 ABCA1/TFPI/GSTP1/FZD5/HSPA5/CCDC47/HMGB1/MAPK14/PPP1R15B/EDNRB/WFS1/RHOA 12 GO:0043550 regulation of lipid kinase activity 3/1115 71/18722 0.802884499249289 0.879302634152195 FLT1/VAV3/PIK3IP1 3 GO:0045824 negative regulation of innate immune response 3/1115 71/18722 0.802884499249289 0.879302634152195 GRN/PARP14/SERPINB9 3 GO:0002821 positive regulation of adaptive immune response 5/1115 112/18722 0.804098721734966 0.880090831353625 IL6ST/RIF1/TFRC/FZD5/MR1 5 GO:0032609 interferon-gamma production 5/1115 112/18722 0.804098721734966 0.880090831353625 CD47/FZD5/HMGB1/TLR3/ISL1 5 GO:0032649 regulation of interferon-gamma production 5/1115 112/18722 0.804098721734966 0.880090831353625 CD47/FZD5/HMGB1/TLR3/ISL1 5 GO:0035249 synaptic transmission, glutamatergic 4/1115 92/18722 0.805260408062952 0.88118165989918 EGFR/CLCN3/RAB3GAP1/CLN3 4 GO:0002639 positive regulation of immunoglobulin production 2/1115 50/18722 0.807012273604564 0.881504093373927 RIF1/TFRC 2 GO:0006220 pyrimidine nucleotide metabolic process 2/1115 50/18722 0.807012273604564 0.881504093373927 AK3/TDG 2 GO:0007080 mitotic metaphase plate congression 2/1115 50/18722 0.807012273604564 0.881504093373927 EML4/KPNB1 2 GO:0007140 male meiotic nuclear division 2/1115 50/18722 0.807012273604564 0.881504093373927 SLC2A8/MLH3 2 GO:0051646 mitochondrion localization 2/1115 50/18722 0.807012273604564 0.881504093373927 LRPPRC/TRAK2 2 GO:0060337 type I interferon signaling pathway 2/1115 50/18722 0.807012273604564 0.881504093373927 HSP90AB1/MAVS 2 GO:0090102 cochlea development 2/1115 50/18722 0.807012273604564 0.881504093373927 ADAM10/PTK7 2 GO:0000469 cleavage involved in rRNA processing 1/1115 27/18722 0.809682725960992 0.881504093373927 RPS21 1 GO:0000737 DNA catabolic process, endonucleolytic 1/1115 27/18722 0.809682725960992 0.881504093373927 DICER1 1 GO:0002227 innate immune response in mucosa 1/1115 27/18722 0.809682725960992 0.881504093373927 RPL39 1 GO:0002825 regulation of T-helper 1 type immune response 1/1115 27/18722 0.809682725960992 0.881504093373927 ANXA1 1 GO:0008053 mitochondrial fusion 1/1115 27/18722 0.809682725960992 0.881504093373927 TFRC 1 GO:0010528 regulation of transposition 1/1115 27/18722 0.809682725960992 0.881504093373927 MOV10 1 GO:0010529 negative regulation of transposition 1/1115 27/18722 0.809682725960992 0.881504093373927 MOV10 1 GO:0016556 mRNA modification 1/1115 27/18722 0.809682725960992 0.881504093373927 ZC3H13 1 GO:0018195 peptidyl-arginine modification 1/1115 27/18722 0.809682725960992 0.881504093373927 PRMT9 1 GO:0032967 positive regulation of collagen biosynthetic process 1/1115 27/18722 0.809682725960992 0.881504093373927 SUCO 1 GO:0034698 response to gonadotropin 1/1115 27/18722 0.809682725960992 0.881504093373927 TGFBR3 1 GO:0042745 circadian sleep/wake cycle 1/1115 27/18722 0.809682725960992 0.881504093373927 ADRB1 1 GO:0045606 positive regulation of epidermal cell differentiation 1/1115 27/18722 0.809682725960992 0.881504093373927 NCOA3 1 GO:0046174 polyol catabolic process 1/1115 27/18722 0.809682725960992 0.881504093373927 TPI1 1 GO:0048520 positive regulation of behavior 1/1115 27/18722 0.809682725960992 0.881504093373927 GJA1 1 GO:0071624 positive regulation of granulocyte chemotaxis 1/1115 27/18722 0.809682725960992 0.881504093373927 CD74 1 GO:1903205 regulation of hydrogen peroxide-induced cell death 1/1115 27/18722 0.809682725960992 0.881504093373927 MET 1 GO:1903859 regulation of dendrite extension 1/1115 27/18722 0.809682725960992 0.881504093373927 ITSN2 1 GO:0002708 positive regulation of lymphocyte mediated immunity 5/1115 113/18722 0.810237947021024 0.881748960282358 RIF1/TFRC/FZD5/MR1/CADM1 5 GO:0071347 cellular response to interleukin-1 5/1115 113/18722 0.810237947021024 0.881748960282358 TFPI/RPS6KA5/CD47/RC3H1/USP10 5 GO:0032729 positive regulation of interferon-gamma production 3/1115 72/18722 0.810476145043421 0.881828436598089 FZD5/TLR3/ISL1 3 GO:0006997 nucleus organization 6/1115 133/18722 0.810792794961108 0.881993221739478 RTN4/PLEC/TPR/SF1/TMEM170A/TMEM43 6 GO:0019217 regulation of fatty acid metabolic process 4/1115 93/18722 0.811952560300111 0.88289505487623 ANXA1/CD74/NCOR1/CAV1 4 GO:0032088 negative regulation of NF-kappaB transcription factor activity 4/1115 93/18722 0.811952560300111 0.88289505487623 BMP7/UFL1/TMSB4X/CAT 4 GO:0007338 single fertilization 7/1115 153/18722 0.812676355219476 0.883502150380122 CD46/ASH1L/ALDOA/HEXB/B4GALT1/FOLR1/CCT3 7 GO:0009584 detection of visible light 2/1115 51/18722 0.815768511300456 0.886142030891788 GNAQ/OPN3 2 GO:0010656 negative regulation of muscle cell apoptotic process 2/1115 51/18722 0.815768511300456 0.886142030891788 BMP7/CFLAR 2 GO:0032964 collagen biosynthetic process 2/1115 51/18722 0.815768511300456 0.886142030891788 SUCO/TRAM2 2 GO:0050982 detection of mechanical stimulus 2/1115 51/18722 0.815768511300456 0.886142030891788 PKD2/CTNNB1 2 GO:0022904 respiratory electron transport chain 5/1115 114/18722 0.816222830665036 0.886455185703952 COX6A1/PLEC/CHCHD2/CYCS/UQCRH 5 GO:0051251 positive regulation of lymphocyte activation 18/1115 362/18722 0.817459596946422 0.887286373377704 CD46/IL6ST/ANXA1/SLC39A10/MIF/DPP4/CD74/PRKDC/RPS3/DOCK8/RIF1/CD47/TFRC/GLI3/VAV3/HMGB1/CAV1/RHOA 18 GO:0030258 lipid modification 10/1115 212/18722 0.817716273418844 0.887286373377704 SLC27A2/PLPP3/SGPP1/CROT/ECHDC2/CPT2/MAPK14/ABCD3/ACOX1/LPCAT3 10 GO:0002637 regulation of immunoglobulin production 3/1115 73/18722 0.81781911282856 0.887286373377704 PRKDC/RIF1/TFRC 3 GO:0009166 nucleotide catabolic process 3/1115 73/18722 0.81781911282856 0.887286373377704 PDE10A/PDE7A/TDG 3 GO:0051298 centrosome duplication 3/1115 73/18722 0.81781911282856 0.887286373377704 NPM1/CEP152/PKD2 3 GO:1903035 negative regulation of response to wounding 4/1115 94/18722 0.818455372778159 0.887796268846525 GJA1/TFPI/C1QTNF1/ANXA2 4 GO:0002313 mature B cell differentiation involved in immune response 1/1115 28/18722 0.82103355562419 0.887887006983503 ITFG2 1 GO:0002507 tolerance induction 1/1115 28/18722 0.82103355562419 0.887887006983503 HMGB1 1 GO:0002675 positive regulation of acute inflammatory response 1/1115 28/18722 0.82103355562419 0.887887006983503 IL6ST 1 GO:0007141 male meiosis I 1/1115 28/18722 0.82103355562419 0.887887006983503 SLC2A8 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/1115 28/18722 0.82103355562419 0.887887006983503 LRP1 1 GO:0009312 oligosaccharide biosynthetic process 1/1115 28/18722 0.82103355562419 0.887887006983503 B4GALT1 1 GO:0010714 positive regulation of collagen metabolic process 1/1115 28/18722 0.82103355562419 0.887887006983503 SUCO 1 GO:0030262 apoptotic nuclear changes 1/1115 28/18722 0.82103355562419 0.887887006983503 DICER1 1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1/1115 28/18722 0.82103355562419 0.887887006983503 EGFR 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/1115 28/18722 0.82103355562419 0.887887006983503 CTNND1 1 GO:0045589 regulation of regulatory T cell differentiation 1/1115 28/18722 0.82103355562419 0.887887006983503 CD46 1 GO:0062125 regulation of mitochondrial gene expression 1/1115 28/18722 0.82103355562419 0.887887006983503 LRPPRC 1 GO:1902624 positive regulation of neutrophil migration 1/1115 28/18722 0.82103355562419 0.887887006983503 CD74 1 GO:1903671 negative regulation of sprouting angiogenesis 1/1115 28/18722 0.82103355562419 0.887887006983503 SEMA6A 1 GO:1903672 positive regulation of sprouting angiogenesis 1/1115 28/18722 0.82103355562419 0.887887006983503 HMGB1 1 GO:0046434 organophosphate catabolic process 7/1115 155/18722 0.82288296151587 0.889706790508957 SMPD1/GPD1L/PLBD1/IDH1/PDE10A/PDE7A/TDG 7 GO:0050777 negative regulation of immune response 9/1115 194/18722 0.823098098626759 0.889759212101289 CD46/GRN/ANXA1/FURIN/PCBP2/PARP14/MAPK14/RC3H1/SERPINB9 9 GO:0010662 regulation of striated muscle cell apoptotic process 2/1115 52/18722 0.824167464859118 0.89019423323545 BMP7/CFLAR 2 GO:0043392 negative regulation of DNA binding 2/1115 52/18722 0.824167464859118 0.89019423323545 RSF1/TMSB4X 2 GO:0071357 cellular response to type I interferon 2/1115 52/18722 0.824167464859118 0.89019423323545 HSP90AB1/MAVS 2 GO:0072523 purine-containing compound catabolic process 2/1115 52/18722 0.824167464859118 0.89019423323545 PDE10A/PDE7A 2 GO:0042773 ATP synthesis coupled electron transport 4/1115 95/18722 0.82477194101924 0.890285260344499 COX6A1/CHCHD2/CYCS/UQCRH 4 GO:0042775 mitochondrial ATP synthesis coupled electron transport 4/1115 95/18722 0.82477194101924 0.890285260344499 COX6A1/CHCHD2/CYCS/UQCRH 4 GO:0045666 positive regulation of neuron differentiation 4/1115 95/18722 0.82477194101924 0.890285260344499 NRCAM/BMP7/REST/RHOA 4 GO:0009201 ribonucleoside triphosphate biosynthetic process 3/1115 74/18722 0.824918745631061 0.890285260344499 ALDOA/ENO1/TMSB4X 3 GO:0022412 cellular process involved in reproduction in multicellular organism 19/1115 384/18722 0.828982255635378 0.894489948026937 LGR5/ITGB1/RPS6/DIAPH2/DYNLL1/SMARCA2/HEXB/PRDX4/DNMT3A/FOLR1/TGFBR1/AFF4/ZFX/CELF1/PAQR7/SLC2A8/EIF2S2/CTNNB1/MLH3 19 GO:0001916 positive regulation of T cell mediated cytotoxicity 1/1115 29/18722 0.83170797444729 0.894729303100203 MR1 1 GO:0003309 type B pancreatic cell differentiation 1/1115 29/18722 0.83170797444729 0.894729303100203 CDK6 1 GO:0006688 glycosphingolipid biosynthetic process 1/1115 29/18722 0.83170797444729 0.894729303100203 B4GALT5 1 GO:0006734 NADH metabolic process 1/1115 29/18722 0.83170797444729 0.894729303100203 ENO1 1 GO:0007143 female meiotic nuclear division 1/1115 29/18722 0.83170797444729 0.894729303100203 MLH3 1 GO:0009218 pyrimidine ribonucleotide metabolic process 1/1115 29/18722 0.83170797444729 0.894729303100203 AK3 1 GO:0032372 negative regulation of sterol transport 1/1115 29/18722 0.83170797444729 0.894729303100203 SREBF2 1 GO:0032375 negative regulation of cholesterol transport 1/1115 29/18722 0.83170797444729 0.894729303100203 SREBF2 1 GO:0042759 long-chain fatty acid biosynthetic process 1/1115 29/18722 0.83170797444729 0.894729303100203 GSTP1 1 GO:0051873 killing by host of symbiont cells 1/1115 29/18722 0.83170797444729 0.894729303100203 GAPDH 1 GO:0051883 killing of cells in other organism involved in symbiotic interaction 1/1115 29/18722 0.83170797444729 0.894729303100203 GAPDH 1 GO:0072539 T-helper 17 cell differentiation 1/1115 29/18722 0.83170797444729 0.894729303100203 RC3H1 1 GO:1900117 regulation of execution phase of apoptosis 1/1115 29/18722 0.83170797444729 0.894729303100203 FZD3 1 GO:0001541 ovarian follicle development 2/1115 53/18722 0.832220587974454 0.894729303100203 ZFX/SOD1 2 GO:0002707 negative regulation of lymphocyte mediated immunity 2/1115 53/18722 0.832220587974454 0.894729303100203 CD46/SERPINB9 2 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 2/1115 53/18722 0.832220587974454 0.894729303100203 MET/ATP2B4 2 GO:0045806 negative regulation of endocytosis 2/1115 53/18722 0.832220587974454 0.894729303100203 ITGAV/CAV1 2 GO:0097479 synaptic vesicle localization 2/1115 53/18722 0.832220587974454 0.894729303100203 KIF5B/CTNNB1 2 GO:0006721 terpenoid metabolic process 4/1115 97/18722 0.836859161775216 0.899535144899915 EGFR/LRP2/LRP1/DHRS3 4 GO:0000724 double-strand break repair via homologous recombination 6/1115 138/18722 0.837227148582706 0.899568473794137 NIPBL/RIF1/REV3L/SETD2/MORF4L1/FUS 6 GO:0007224 smoothened signaling pathway 6/1115 138/18722 0.837227148582706 0.899568473794137 DLG5/HERC4/GLI3/FGFR2/CREBBP/GPC3 6 GO:0014823 response to activity 3/1115 76/18722 0.838409785860002 0.900657916842364 COL4A2/PRKDC/CAT 3 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/1115 54/18722 0.839939238554067 0.900979002415311 CD46/RC3H1 2 GO:0006968 cellular defense response 2/1115 54/18722 0.839939238554067 0.900979002415311 ITGB1/LGALS3BP 2 GO:0050864 regulation of B cell activation 9/1115 198/18722 0.840367581705393 0.900979002415311 SLC39A10/MIF/ZFP36L1/CD74/RIF1/TFRC/VAV3/RC3H1/ATM 9 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/1115 30/18722 0.84174625661127 0.900979002415311 DICER1 1 GO:0009264 deoxyribonucleotide catabolic process 1/1115 30/18722 0.84174625661127 0.900979002415311 TDG 1 GO:0010669 epithelial structure maintenance 1/1115 30/18722 0.84174625661127 0.900979002415311 SLC22A5 1 GO:0015721 bile acid and bile salt transport 1/1115 30/18722 0.84174625661127 0.900979002415311 ABCD3 1 GO:0017145 stem cell division 1/1115 30/18722 0.84174625661127 0.900979002415311 NCOA3 1 GO:0031365 N-terminal protein amino acid modification 1/1115 30/18722 0.84174625661127 0.900979002415311 CREBBP 1 GO:0032480 negative regulation of type I interferon production 1/1115 30/18722 0.84174625661127 0.900979002415311 REL 1 GO:0034508 centromere complex assembly 1/1115 30/18722 0.84174625661127 0.900979002415311 SENP6 1 GO:0034694 response to prostaglandin 1/1115 30/18722 0.84174625661127 0.900979002415311 TGFBR3 1 GO:0043032 positive regulation of macrophage activation 1/1115 30/18722 0.84174625661127 0.900979002415311 CTSC 1 GO:0045577 regulation of B cell differentiation 1/1115 30/18722 0.84174625661127 0.900979002415311 ZFP36L1 1 GO:0045948 positive regulation of translational initiation 1/1115 30/18722 0.84174625661127 0.900979002415311 DNAJC3 1 GO:0060292 long-term synaptic depression 1/1115 30/18722 0.84174625661127 0.900979002415311 PPP1R9A 1 GO:0070498 interleukin-1-mediated signaling pathway 1/1115 30/18722 0.84174625661127 0.900979002415311 RPS6KA5 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/1115 30/18722 0.84174625661127 0.900979002415311 CALM1 1 GO:0051259 protein complex oligomerization 11/1115 238/18722 0.845258824703981 0.904557399297365 MIF/ALDOA/CD74/SLC1A5/YME1L1/SLC9A1/TRPM7/HGSNAT/RNF213/PKD2/FUS 11 GO:0000725 recombinational repair 6/1115 140/18722 0.846932506663938 0.905870983936687 NIPBL/RIF1/REV3L/SETD2/MORF4L1/FUS 6 GO:0006360 transcription by RNA polymerase I 2/1115 55/18722 0.847334649518602 0.905870983936687 NCL/ERBB2 2 GO:0051898 negative regulation of protein kinase B signaling 2/1115 55/18722 0.847334649518602 0.905870983936687 DAG1/DLG1 2 GO:0061098 positive regulation of protein tyrosine kinase activity 2/1115 55/18722 0.847334649518602 0.905870983936687 ERBB3/ADAM17 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/1115 55/18722 0.847334649518602 0.905870983936687 RTN4/ROCK1 2 GO:0031348 negative regulation of defense response 12/1115 258/18722 0.84806476245686 0.906295057984702 GRN/ASH1L/SERPINF1/FURIN/GSTP1/PCBP2/PARP14/MAPK14/LPCAT3/ISL1/SERPINB9/SOD1 12 GO:0002444 myeloid leukocyte mediated immunity 4/1115 99/18722 0.848240570284614 0.906295057984702 ADAM17/DHX36/MAVS/SERPINB9 4 GO:0031341 regulation of cell killing 4/1115 99/18722 0.848240570284614 0.906295057984702 HSP90AB1/SERPINB9/MR1/CADM1 4 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 3/1115 78/18722 0.850993377073772 0.907263635622412 CFLAR/CYCS/HSPE1 3 GO:0043537 negative regulation of blood vessel endothelial cell migration 3/1115 78/18722 0.850993377073772 0.907263635622412 ATP2B4/HMGB1/RHOA 3 GO:0002717 positive regulation of natural killer cell mediated immunity 1/1115 31/18722 0.851186280358244 0.907263635622412 CADM1 1 GO:0021988 olfactory lobe development 1/1115 31/18722 0.851186280358244 0.907263635622412 SEMA7A 1 GO:0034656 nucleobase-containing small molecule catabolic process 1/1115 31/18722 0.851186280358244 0.907263635622412 MGAT1 1 GO:0036474 cell death in response to hydrogen peroxide 1/1115 31/18722 0.851186280358244 0.907263635622412 MET 1 GO:0045066 regulatory T cell differentiation 1/1115 31/18722 0.851186280358244 0.907263635622412 CD46 1 GO:0045987 positive regulation of smooth muscle contraction 1/1115 31/18722 0.851186280358244 0.907263635622412 RHOA 1 GO:0046386 deoxyribose phosphate catabolic process 1/1115 31/18722 0.851186280358244 0.907263635622412 TDG 1 GO:0048710 regulation of astrocyte differentiation 1/1115 31/18722 0.851186280358244 0.907263635622412 IL6ST 1 GO:0097106 postsynaptic density organization 1/1115 31/18722 0.851186280358244 0.907263635622412 DLG1 1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/1115 31/18722 0.851186280358244 0.907263635622412 CFLAR 1 GO:0006641 triglyceride metabolic process 4/1115 100/18722 0.85367508646832 0.909255966976477 SEL1L/CAV1/CAT/GPAT4 4 GO:0002263 cell activation involved in immune response 13/1115 279/18722 0.854348298840856 0.909255966976477 LRP1/CD46/GRN/ANXA1/RPS6/APP/CD74/RIF1/TFRC/FOXP1/HMGB1/ITFG2/RC3H1 13 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 2/1115 56/18722 0.854417903412808 0.909255966976477 MR1/CADM1 2 GO:0002711 positive regulation of T cell mediated immunity 2/1115 56/18722 0.854417903412808 0.909255966976477 FZD5/MR1 2 GO:0002886 regulation of myeloid leukocyte mediated immunity 2/1115 56/18722 0.854417903412808 0.909255966976477 DHX36/MAVS 2 GO:0010658 striated muscle cell apoptotic process 2/1115 56/18722 0.854417903412808 0.909255966976477 BMP7/CFLAR 2 GO:0045071 negative regulation of viral genome replication 2/1115 56/18722 0.854417903412808 0.909255966976477 MPHOSPH8/MAVS 2 GO:0045599 negative regulation of fat cell differentiation 2/1115 56/18722 0.854417903412808 0.909255966976477 JAG1/TRPV4 2 GO:0017157 regulation of exocytosis 9/1115 202/18722 0.856289450663061 0.91106603768236 ANXA1/CALM1/EXPH5/ATP2A2/SYT7/ATP6AP1/RAB3GAP1/RAB13/REST 9 GO:0051279 regulation of release of sequestered calcium ion into cytosol 3/1115 79/18722 0.856958816902314 0.911596557768769 CALM1/DMD/PKD2 3 GO:1990266 neutrophil migration 5/1115 122/18722 0.85879847947194 0.913080122549763 CSF3R/DPP4/CD74/PPIA/VAV3 5 GO:0006308 DNA catabolic process 1/1115 32/18722 0.86006367040696 0.913080122549763 DICER1 1 GO:0008156 negative regulation of DNA replication 1/1115 32/18722 0.86006367040696 0.913080122549763 S100A11 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/1115 32/18722 0.86006367040696 0.913080122549763 CFLAR 1 GO:0035456 response to interferon-beta 1/1115 32/18722 0.86006367040696 0.913080122549763 TLR3 1 GO:0035883 enteroendocrine cell differentiation 1/1115 32/18722 0.86006367040696 0.913080122549763 CDK6 1 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 1/1115 32/18722 0.86006367040696 0.913080122549763 ANXA1 1 GO:0045684 positive regulation of epidermis development 1/1115 32/18722 0.86006367040696 0.913080122549763 NCOA3 1 GO:0090140 regulation of mitochondrial fission 1/1115 32/18722 0.86006367040696 0.913080122549763 INF2 1 GO:1900745 positive regulation of p38MAPK cascade 1/1115 32/18722 0.86006367040696 0.913080122549763 EMC10 1 GO:0030219 megakaryocyte differentiation 2/1115 57/18722 0.861199910478528 0.913741319961221 SCIN/WASF2 2 GO:0051155 positive regulation of striated muscle cell differentiation 2/1115 57/18722 0.861199910478528 0.913741319961221 MORF4L2/MAPK14 2 GO:0051289 protein homotetramerization 2/1115 57/18722 0.861199910478528 0.913741319961221 ALDOA/PKD2 2 GO:0051303 establishment of chromosome localization 3/1115 80/18722 0.862714140215822 0.915166062907267 EML4/DYNC1H1/KPNB1 3 GO:0035710 CD4-positive, alpha-beta T cell activation 4/1115 102/18722 0.86404909015551 0.916400097802993 ANXA1/FOXP1/HMGB1/RC3H1 4 GO:0043433 negative regulation of DNA-binding transcription factor activity 8/1115 185/18722 0.867035240789699 0.917745705555969 BMP7/UFL1/TCF7L2/TMSB4X/FZD6/PKD2/CAT/WFS1 8 GO:0009161 ribonucleoside monophosphate metabolic process 2/1115 58/18722 0.86769138986795 0.917745705555969 DLG1/AK3 2 GO:0010043 response to zinc ion 2/1115 58/18722 0.86769138986795 0.917745705555969 P2RX4/GGH 2 GO:0010574 regulation of vascular endothelial growth factor production 2/1115 58/18722 0.86769138986795 0.917745705555969 IL6ST/ISL1 2 GO:0001523 retinoid metabolic process 3/1115 81/18722 0.868264926704882 0.917745705555969 LRP2/LRP1/DHRS3 3 GO:0001960 negative regulation of cytokine-mediated signaling pathway 3/1115 81/18722 0.868264926704882 0.917745705555969 GSTP1/PARP14/CAV1 3 GO:0051149 positive regulation of muscle cell differentiation 3/1115 81/18722 0.868264926704882 0.917745705555969 MORF4L2/PIAS1/MAPK14 3 GO:0001881 receptor recycling 1/1115 33/18722 0.868411931910237 0.917745705555969 ANXA2 1 GO:0002335 mature B cell differentiation 1/1115 33/18722 0.868411931910237 0.917745705555969 ITFG2 1 GO:0006336 DNA replication-independent nucleosome assembly 1/1115 33/18722 0.868411931910237 0.917745705555969 ATRX 1 GO:0010984 regulation of lipoprotein particle clearance 1/1115 33/18722 0.868411931910237 0.917745705555969 ANXA2 1 GO:0040020 regulation of meiotic nuclear division 1/1115 33/18722 0.868411931910237 0.917745705555969 CDC20 1 GO:0071763 nuclear membrane organization 1/1115 33/18722 0.868411931910237 0.917745705555969 TMEM43 1 GO:0099084 postsynaptic specialization organization 1/1115 33/18722 0.868411931910237 0.917745705555969 DLG1 1 GO:0099174 regulation of presynapse organization 1/1115 33/18722 0.868411931910237 0.917745705555969 APP 1 GO:0110110 positive regulation of animal organ morphogenesis 1/1115 33/18722 0.868411931910237 0.917745705555969 CTNNB1 1 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 1/1115 33/18722 0.868411931910237 0.917745705555969 KANK1 1 GO:1905606 regulation of presynapse assembly 1/1115 33/18722 0.868411931910237 0.917745705555969 APP 1 GO:0019233 sensory perception of pain 4/1115 103/18722 0.868995599856665 0.917972816108346 MME/P2RX4/SLC9A1/EDNRB 4 GO:0007269 neurotransmitter secretion 6/1115 145/18722 0.869142645706628 0.917972816108346 CALM1/ATP2A2/SYT7/PPP1R9A/RAB3GAP1/MCTP2 6 GO:0099643 signal release from synapse 6/1115 145/18722 0.869142645706628 0.917972816108346 CALM1/ATP2A2/SYT7/PPP1R9A/RAB3GAP1/MCTP2 6 GO:0001910 regulation of leukocyte mediated cytotoxicity 3/1115 82/18722 0.873616732983069 0.921724088485147 SERPINB9/MR1/CADM1 3 GO:0002312 B cell activation involved in immune response 3/1115 82/18722 0.873616732983069 0.921724088485147 RIF1/TFRC/ITFG2 3 GO:0008543 fibroblast growth factor receptor signaling pathway 3/1115 82/18722 0.873616732983069 0.921724088485147 GPC1/FGFR2/CTNNB1 3 GO:0050000 chromosome localization 3/1115 82/18722 0.873616732983069 0.921724088485147 EML4/DYNC1H1/KPNB1 3 GO:0002820 negative regulation of adaptive immune response 2/1115 59/18722 0.873902853701407 0.921724088485147 CD46/RC3H1 2 GO:0051353 positive regulation of oxidoreductase activity 2/1115 59/18722 0.873902853701407 0.921724088485147 CALM1/PDP2 2 GO:2000351 regulation of endothelial cell apoptotic process 2/1115 59/18722 0.873902853701407 0.921724088485147 ANO6/PRKCI 2 GO:0002446 neutrophil mediated immunity 1/1115 34/18722 0.876262576456231 0.922754614536453 ADAM17 1 GO:0009303 rRNA transcription 1/1115 34/18722 0.876262576456231 0.922754614536453 NCL 1 GO:0009649 entrainment of circadian clock 1/1115 34/18722 0.876262576456231 0.922754614536453 GNAQ 1 GO:0030851 granulocyte differentiation 1/1115 34/18722 0.876262576456231 0.922754614536453 FASN 1 GO:0032770 positive regulation of monooxygenase activity 1/1115 34/18722 0.876262576456231 0.922754614536453 CALM1 1 GO:0034724 DNA replication-independent nucleosome organization 1/1115 34/18722 0.876262576456231 0.922754614536453 ATRX 1 GO:0048261 negative regulation of receptor-mediated endocytosis 1/1115 34/18722 0.876262576456231 0.922754614536453 ITGAV 1 GO:0070232 regulation of T cell apoptotic process 1/1115 34/18722 0.876262576456231 0.922754614536453 DOCK8 1 GO:0007018 microtubule-based movement 18/1115 382/18722 0.876833164303085 0.923173390694966 KTN1/APP/ATP2B4/ASH1L/DST/ARHGAP21/PCM1/RAB6A/DYNC1H1/VPS13A/KIF5B/LRPPRC/KPNB1/HSPB1/CLN3/TRAK2/DNAJA1/SOD1 18 GO:0001906 cell killing 8/1115 188/18722 0.877931334901948 0.924147357460863 GAPDH/PRDX1/CTSC/HSP90AB1/KIF5B/SERPINB9/MR1/CADM1 8 GO:0016079 synaptic vesicle exocytosis 4/1115 105/18722 0.87842530457099 0.924485058368719 CALM1/ATP2A2/SYT7/RAB3GAP1 4 GO:0001510 RNA methylation 3/1115 83/18722 0.878775081800407 0.924488701819187 ZC3H13/RNMT/TARBP1 3 GO:1901292 nucleoside phosphate catabolic process 3/1115 83/18722 0.878775081800407 0.924488701819187 PDE10A/PDE7A/TDG 3 GO:0006289 nucleotide-excision repair 2/1115 60/18722 0.879844593698076 0.925249219175503 DDB1/HMGB1 2 GO:1903670 regulation of sprouting angiogenesis 2/1115 60/18722 0.879844593698076 0.925249219175503 SEMA6A/HMGB1 2 GO:0006911 phagocytosis, engulfment 5/1115 127/18722 0.880971500254082 0.926251839278563 ABCA1/ANO6/CLCN3/RHOBTB1/RAB31 5 GO:0001824 blastocyst development 4/1115 106/18722 0.882915583296605 0.927784058896163 N4BP2L2/RTN4/FURIN/TGFBR1 4 GO:0003298 physiological muscle hypertrophy 1/1115 35/18722 0.883645240585688 0.927784058896163 AKAP13 1 GO:0003301 physiological cardiac muscle hypertrophy 1/1115 35/18722 0.883645240585688 0.927784058896163 AKAP13 1 GO:0045922 negative regulation of fatty acid metabolic process 1/1115 35/18722 0.883645240585688 0.927784058896163 NCOR1 1 GO:0046627 negative regulation of insulin receptor signaling pathway 1/1115 35/18722 0.883645240585688 0.927784058896163 KANK1 1 GO:0061049 cell growth involved in cardiac muscle cell development 1/1115 35/18722 0.883645240585688 0.927784058896163 AKAP13 1 GO:0070536 protein K63-linked deubiquitination 1/1115 35/18722 0.883645240585688 0.927784058896163 USP25 1 GO:0045834 positive regulation of lipid metabolic process 6/1115 149/18722 0.884919011454132 0.928938773526074 ANXA1/FLT1/CD74/SORBS1/VAV3/ACSL3 6 GO:1905515 non-motile cilium assembly 2/1115 61/18722 0.8855266701301 0.929393924085828 CEP350/PCM1 2 GO:0000018 regulation of DNA recombination 4/1115 107/18722 0.887260862482138 0.930417525723896 RIF1/TFRC/SETD2/FUS 4 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/1115 107/18722 0.887260862482138 0.930417525723896 RIF1/TFRC/FZD5/MR1 4 GO:0071868 cellular response to monoamine stimulus 4/1115 107/18722 0.887260862482138 0.930417525723896 APP/ATP2B4/SLC9A1/NCSTN 4 GO:0071870 cellular response to catecholamine stimulus 4/1115 107/18722 0.887260862482138 0.930417525723896 APP/ATP2B4/SLC9A1/NCSTN 4 GO:0071103 DNA conformation change 13/1115 290/18722 0.887373298555175 0.930417525723896 ANXA1/NPM1/ATRX/HMGB3/RSF1/TOP2B/DHX36/CHD6/HNRNPA2B1/HMGB1/SHPRH/NAV2/NUSAP1 13 GO:0006302 double-strand break repair 11/1115 251/18722 0.888032012243423 0.930925370777074 NIPBL/PRKDC/UBR5/RIF1/REV3L/TRIP12/SETD2/HMGB1/ATM/MORF4L1/FUS 11 GO:0002709 regulation of T cell mediated immunity 3/1115 85/18722 0.888533270897812 0.931267988481236 FZD5/HMGB1/MR1 3 GO:0008207 C21-steroid hormone metabolic process 1/1115 36/18722 0.890587797269317 0.931592525395941 REST 1 GO:0014046 dopamine secretion 1/1115 36/18722 0.890587797269317 0.931592525395941 SYT7 1 GO:0014059 regulation of dopamine secretion 1/1115 36/18722 0.890587797269317 0.931592525395941 SYT7 1 GO:0042119 neutrophil activation 1/1115 36/18722 0.890587797269317 0.931592525395941 GRN 1 GO:0043949 regulation of cAMP-mediated signaling 1/1115 36/18722 0.890587797269317 0.931592525395941 RAPGEF2 1 GO:0045652 regulation of megakaryocyte differentiation 1/1115 36/18722 0.890587797269317 0.931592525395941 SCIN 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/1115 36/18722 0.890587797269317 0.931592525395941 ADAM17 1 GO:0045746 negative regulation of Notch signaling pathway 1/1115 36/18722 0.890587797269317 0.931592525395941 BMP7 1 GO:0070306 lens fiber cell differentiation 1/1115 36/18722 0.890587797269317 0.931592525395941 ABI2 1 GO:0086010 membrane depolarization during action potential 1/1115 36/18722 0.890587797269317 0.931592525395941 ANK3 1 GO:0019933 cAMP-mediated signaling 2/1115 62/18722 0.890958902871271 0.931798155226193 PDE7A/RAPGEF2 2 GO:0002832 negative regulation of response to biotic stimulus 4/1115 108/18722 0.891464665791298 0.932144506592194 GRN/PCBP2/PARP14/SERPINB9 4 GO:0045921 positive regulation of exocytosis 3/1115 86/18722 0.893143903818032 0.933534710744807 EXPH5/SYT7/ATP6AP1 3 GO:0060761 negative regulation of response to cytokine stimulus 3/1115 86/18722 0.893143903818032 0.933534710744807 GSTP1/PARP14/CAV1 3 GO:0002696 positive regulation of leukocyte activation 19/1115 409/18722 0.895613939156086 0.933665649905293 CD46/IL6ST/ANXA1/SLC39A10/MIF/CTSC/DPP4/CD74/PRKDC/RPS3/DOCK8/RIF1/CD47/TFRC/GLI3/VAV3/HMGB1/CAV1/RHOA 19 GO:0050871 positive regulation of B cell activation 6/1115 152/18722 0.895668963746056 0.933665649905293 SLC39A10/MIF/CD74/RIF1/TFRC/VAV3 6 GO:0002704 negative regulation of leukocyte mediated immunity 2/1115 63/18722 0.896150864330321 0.933665649905293 CD46/SERPINB9 2 GO:0031343 positive regulation of cell killing 2/1115 63/18722 0.896150864330321 0.933665649905293 MR1/CADM1 2 GO:0099601 regulation of neurotransmitter receptor activity 2/1115 63/18722 0.896150864330321 0.933665649905293 AKAP9/APP 2 GO:0010469 regulation of signaling receptor activity 7/1115 173/18722 0.896165085963982 0.933665649905293 AKAP9/ITGB1/NRP1/APP/NCOA3/ADAM17/LY6E 7 GO:0006839 mitochondrial transport 11/1115 254/18722 0.896394930465693 0.933665649905293 LMAN1/SLC9A1/FZD5/VDAC1/UBE2L3/NPEPPS/SLC25A36/CPT2/SLC35F6/SREBF2/HSPA1A 11 GO:0009165 nucleotide biosynthetic process 11/1115 254/18722 0.896394930465693 0.933665649905293 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/RRM2B/ACSL3/ELOVL1 11 GO:0006661 phosphatidylinositol biosynthetic process 5/1115 131/18722 0.896503831446654 0.933665649905293 PGAP1/CDS1/SMG1/GPAA1/ATM 5 GO:0045089 positive regulation of innate immune response 5/1115 131/18722 0.896503831446654 0.933665649905293 PRKDC/HMGB1/MAVS/CREBBP/CADM1 5 GO:0002369 T cell cytokine production 1/1115 37/18722 0.897116460763093 0.933665649905293 FZD5 1 GO:0002724 regulation of T cell cytokine production 1/1115 37/18722 0.897116460763093 0.933665649905293 FZD5 1 GO:0003016 respiratory system process 1/1115 37/18722 0.897116460763093 0.933665649905293 GAA 1 GO:0006904 vesicle docking involved in exocytosis 1/1115 37/18722 0.897116460763093 0.933665649905293 RAB13 1 GO:0007340 acrosome reaction 1/1115 37/18722 0.897116460763093 0.933665649905293 B4GALT1 1 GO:0021532 neural tube patterning 1/1115 37/18722 0.897116460763093 0.933665649905293 GLI3 1 GO:0033260 nuclear DNA replication 1/1115 37/18722 0.897116460763093 0.933665649905293 ATRX 1 GO:0033363 secretory granule organization 1/1115 37/18722 0.897116460763093 0.933665649905293 ABCA1 1 GO:0043368 positive T cell selection 1/1115 37/18722 0.897116460763093 0.933665649905293 CD74 1 GO:0060416 response to growth hormone 1/1115 37/18722 0.897116460763093 0.933665649905293 CSH1 1 GO:0071985 multivesicular body sorting pathway 1/1115 37/18722 0.897116460763093 0.933665649905293 EXPH5 1 GO:1900077 negative regulation of cellular response to insulin stimulus 1/1115 37/18722 0.897116460763093 0.933665649905293 KANK1 1 GO:0019646 aerobic electron transport chain 3/1115 87/18722 0.897582649417486 0.93378678200311 COX6A1/CYCS/UQCRH 3 GO:0051262 protein tetramerization 3/1115 87/18722 0.897582649417486 0.93378678200311 ALDOA/TRPM7/PKD2 3 GO:0009063 cellular amino acid catabolic process 4/1115 110/18722 0.899461848305186 0.935195094080115 GLDC/ATP2B4/ALDH4A1/BCAT2 4 GO:0030317 flagellated sperm motility 4/1115 110/18722 0.899461848305186 0.935195094080115 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0097722 sperm motility 4/1115 110/18722 0.899461848305186 0.935195094080115 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0042113 B cell activation 15/1115 334/18722 0.900058669002657 0.93563341779696 ITGB1/SLC39A10/MIF/ZFP36L1/CD74/PRKDC/RIF1/TFRC/RBPJ/ADAM17/VAV3/IRF2BP2/ITFG2/RC3H1/ATM 15 GO:0046854 phosphatidylinositol phosphate biosynthetic process 2/1115 64/18722 0.90111187407647 0.936363623140186 SMG1/ATM 2 GO:0070542 response to fatty acid 2/1115 64/18722 0.90111187407647 0.936363623140186 GLDC/CAT 2 GO:1901293 nucleoside phosphate biosynthetic process 11/1115 256/18722 0.901679037975619 0.936406537237103 SLC26A2/ALDOA/ACSS1/ENO1/ADCY7/TMSB4X/TECR/AK3/RRM2B/ACSL3/ELOVL1 11 GO:0046395 carboxylic acid catabolic process 10/1115 236/18722 0.901717491798567 0.936406537237103 GLDC/SLC27A2/ATP2B4/CROT/ECHDC2/CPT2/ABCD3/ACOX1/ALDH4A1/BCAT2 10 GO:0030101 natural killer cell activation 3/1115 88/18722 0.901854732060907 0.936406537237103 PBX1/PRDX1/HECTD1 3 GO:1901657 glycosyl compound metabolic process 3/1115 88/18722 0.901854732060907 0.936406537237103 GUSB/ERH/FUCA1 3 GO:0002385 mucosal immune response 1/1115 38/18722 0.903255885234549 0.936956814133393 RPL39 1 GO:0035886 vascular associated smooth muscle cell differentiation 1/1115 38/18722 0.903255885234549 0.936956814133393 NFATC3 1 GO:0072538 T-helper 17 type immune response 1/1115 38/18722 0.903255885234549 0.936956814133393 RC3H1 1 GO:0071867 response to monoamine 4/1115 111/18722 0.903262169384636 0.936956814133393 APP/ATP2B4/SLC9A1/NCSTN 4 GO:0071869 response to catecholamine 4/1115 111/18722 0.903262169384636 0.936956814133393 APP/ATP2B4/SLC9A1/NCSTN 4 GO:0006333 chromatin assembly or disassembly 7/1115 177/18722 0.908408956492571 0.941658363591641 NPM1/ATRX/ARID1A/RSF1/SMARCC1/HMGB1/SHPRH 7 GO:0046631 alpha-beta T cell activation 6/1115 156/18722 0.908658291338422 0.941658363591641 ANXA1/GLI3/FOXP1/HMGB1/RC3H1/RHOA 6 GO:0001914 regulation of T cell mediated cytotoxicity 1/1115 39/18722 0.909029257529747 0.941658363591641 MR1 1 GO:0002701 negative regulation of production of molecular mediator of immune response 1/1115 39/18722 0.909029257529747 0.941658363591641 PRKDC 1 GO:0021587 cerebellum morphogenesis 1/1115 39/18722 0.909029257529747 0.941658363591641 HSPA5 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/1115 39/18722 0.909029257529747 0.941658363591641 YBX1 1 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 1/1115 39/18722 0.909029257529747 0.941658363591641 ANXA1 1 GO:0009581 detection of external stimulus 5/1115 135/18722 0.910250115094343 0.942616032513614 CDS1/GNAQ/OPN3/PKD2/CTNNB1 5 GO:0042446 hormone biosynthetic process 2/1115 66/18722 0.910377030713881 0.942616032513614 ATP1A1/REST 2 GO:0044344 cellular response to fibroblast growth factor stimulus 4/1115 113/18722 0.910483401324726 0.942616032513614 ZFP36L1/GPC1/FGFR2/CTNNB1 4 GO:0006260 DNA replication 11/1115 260/18722 0.911577437397497 0.943565711179767 EGFR/BOD1L1/ATRX/S100A11/ZBTB38/PTMS/REV3L/NFIB/RBBP6/RRM2B/ANKRD17 11 GO:0016054 organic acid catabolic process 10/1115 240/18722 0.911971404890449 0.943790527371605 GLDC/SLC27A2/ATP2B4/CROT/ECHDC2/CPT2/ABCD3/ACOX1/ALDH4A1/BCAT2 10 GO:1903305 regulation of regulated secretory pathway 5/1115 136/18722 0.913426383320677 0.945113073749824 CALM1/ATP2A2/SYT7/RAB3GAP1/REST 5 GO:0006730 one-carbon metabolic process 1/1115 40/18722 0.914458384428764 0.945147168961471 AHCYL1 1 GO:0009394 2'-deoxyribonucleotide metabolic process 1/1115 40/18722 0.914458384428764 0.945147168961471 TDG 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/1115 40/18722 0.914458384428764 0.945147168961471 LGR4 1 GO:0042073 intraciliary transport 1/1115 40/18722 0.914458384428764 0.945147168961471 PCM1 1 GO:0055081 anion homeostasis 1/1115 40/18722 0.914458384428764 0.945147168961471 ATP6V1B1 1 GO:0006513 protein monoubiquitination 2/1115 67/18722 0.91469852444726 0.945147168961471 DDB1/SKP1 2 GO:0035914 skeletal muscle cell differentiation 2/1115 67/18722 0.91469852444726 0.945147168961471 DDX17/GPC1 2 GO:0065004 protein-DNA complex assembly 8/1115 201/18722 0.916964003035536 0.947304723724212 NPM1/ATRX/RSF1/SENP6/PIAS1/HMGB1/ATF7IP/SHPRH 8 GO:0090630 activation of GTPase activity 4/1115 115/18722 0.917221173862946 0.947387085945883 EVI5/ARHGAP29/CCDC125/TBC1D2B 4 GO:0050867 positive regulation of cell activation 19/1115 420/18722 0.917441100586329 0.947430954744761 CD46/IL6ST/ANXA1/SLC39A10/MIF/CTSC/DPP4/CD74/PRKDC/RPS3/DOCK8/RIF1/CD47/TFRC/GLI3/VAV3/HMGB1/CAV1/RHOA 19 GO:0031640 killing of cells of other organism 2/1115 68/18722 0.918823758632386 0.948338998109568 GAPDH/SERPINB9 2 GO:0032496 response to lipopolysaccharide 15/1115 343/18722 0.919184423410102 0.948338998109568 ABCA1/GJA1/TFPI/ATP2A2/GSTP1/ADAM17/FOXP1/HMGB1/MAPK14/EDNRB/TAB2/FGFR2/PRDX3/RHOA/HPGD 15 GO:0009582 detection of abiotic stimulus 5/1115 138/18722 0.919483771957623 0.948338998109568 CDS1/GNAQ/OPN3/PKD2/CTNNB1 5 GO:0002251 organ or tissue specific immune response 1/1115 41/18722 0.919563774716845 0.948338998109568 RPL39 1 GO:0006418 tRNA aminoacylation for protein translation 1/1115 41/18722 0.919563774716845 0.948338998109568 IARS2 1 GO:0030488 tRNA methylation 1/1115 41/18722 0.919563774716845 0.948338998109568 TARBP1 1 GO:0044786 cell cycle DNA replication 1/1115 41/18722 0.919563774716845 0.948338998109568 ATRX 1 GO:0002237 response to molecule of bacterial origin 16/1115 363/18722 0.919888725083646 0.948490904446038 ABCA1/GJA1/TFPI/ATP2A2/GSTP1/FZD5/ADAM17/FOXP1/HMGB1/MAPK14/EDNRB/TAB2/FGFR2/PRDX3/RHOA/HPGD 16 GO:0006720 isoprenoid metabolic process 4/1115 116/18722 0.92041701636286 0.94866919891145 EGFR/LRP2/LRP1/DHRS3 4 GO:0007006 mitochondrial membrane organization 4/1115 116/18722 0.92041701636286 0.94866919891145 CALM1/SLC9A1/SLC35F6/HSPA1A 4 GO:0006310 DNA recombination 13/1115 305/18722 0.922365263105417 0.950493754047447 NIPBL/PRKDC/HMGB3/RIF1/TFRC/TOP2B/REV3L/SETD2/HMGB1/ATM/MLH3/MORF4L1/FUS 13 GO:0070192 chromosome organization involved in meiotic cell cycle 2/1115 69/18722 0.92276075572573 0.95071780679654 ATRX/MLH3 2 GO:0000266 mitochondrial fission 1/1115 42/18722 0.924364716379 0.950719171787224 INF2 1 GO:0007212 dopamine receptor signaling pathway 1/1115 42/18722 0.924364716379 0.950719171787224 NCSTN 1 GO:0019432 triglyceride biosynthetic process 1/1115 42/18722 0.924364716379 0.950719171787224 GPAT4 1 GO:0019692 deoxyribose phosphate metabolic process 1/1115 42/18722 0.924364716379 0.950719171787224 TDG 1 GO:0021575 hindbrain morphogenesis 1/1115 42/18722 0.924364716379 0.950719171787224 HSPA5 1 GO:0032689 negative regulation of interferon-gamma production 1/1115 42/18722 0.924364716379 0.950719171787224 HMGB1 1 GO:0032965 regulation of collagen biosynthetic process 1/1115 42/18722 0.924364716379 0.950719171787224 SUCO 1 GO:0071312 cellular response to alkaloid 1/1115 42/18722 0.924364716379 0.950719171787224 SLC1A3 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/1115 42/18722 0.924364716379 0.950719171787224 RHOA 1 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 2/1115 70/18722 0.926517279752924 0.952749567912338 RIF1/TFRC 2 GO:0006119 oxidative phosphorylation 5/1115 141/18722 0.927868035142568 0.953954831431961 COX6A1/CHCHD2/CYCS/RHOA/UQCRH 5 GO:0036230 granulocyte activation 1/1115 43/18722 0.928879349207555 0.954626919233713 GRN 1 GO:0120178 steroid hormone biosynthetic process 1/1115 43/18722 0.928879349207555 0.954626919233713 REST 1 GO:0071774 response to fibroblast growth factor 4/1115 120/18722 0.93212135365613 0.957774424012717 ZFP36L1/GPC1/FGFR2/CTNNB1 4 GO:0002764 immune response-regulating signaling pathway 21/1115 468/18722 0.932581555088268 0.958062906025835 COLEC12/LGR4/SLC39A10/RTN4/RPS3/KCNN4/CD47/PUM2/WNK1/VAV3/FOXP1/PUM1/HMGB1/CAV1/APPL1/XIAP/TLR3/ANKRD17/RC3H1/CREBBP/HSPA1A 21 GO:0043039 tRNA aminoacylation 1/1115 44/18722 0.933124733095 0.958436504423663 IARS2 1 GO:1990868 response to chemokine 3/1115 97/18722 0.933622815494001 0.958579271523552 DOCK8/WNK1/RHOA 3 GO:1990869 cellular response to chemokine 3/1115 97/18722 0.933622815494001 0.958579271523552 DOCK8/WNK1/RHOA 3 GO:0006887 exocytosis 15/1115 352/18722 0.935156408857239 0.95996924954601 ANXA1/SCIN/CALM1/EXPH5/ARFGEF1/ATP2A2/SYT7/ATP6AP1/MIA3/RAB3GAP1/PRSS12/RAB13/RAB31/REST/SYNGR2 15 GO:0002920 regulation of humoral immune response 1/1115 45/18722 0.937116912268309 0.961057855282463 CD46 1 GO:0006903 vesicle targeting 1/1115 45/18722 0.937116912268309 0.961057855282463 TRIP11 1 GO:0010824 regulation of centrosome duplication 1/1115 45/18722 0.937116912268309 0.961057855282463 NPM1 1 GO:0045910 negative regulation of DNA recombination 1/1115 45/18722 0.937116912268309 0.961057855282463 RIF1 1 GO:0071354 cellular response to interleukin-6 1/1115 45/18722 0.937116912268309 0.961057855282463 IL6ST 1 GO:0042180 cellular ketone metabolic process 8/1115 211/18722 0.939205038077548 0.962879684926267 ANXA1/ATP2B4/CD74/NCOR1/TPI1/CLN3/CAV1/REST 8 GO:0051153 regulation of striated muscle cell differentiation 3/1115 99/18722 0.939254054897171 0.962879684926267 YBX1/MORF4L2/MAPK14 3 GO:0050852 T cell receptor signaling pathway 4/1115 123/18722 0.939852528477192 0.963308245256235 RPS3/KCNN4/WNK1/RC3H1 4 GO:0006383 transcription by RNA polymerase III 1/1115 46/18722 0.940870975705737 0.963797033632565 DHX36 1 GO:0010830 regulation of myotube differentiation 1/1115 46/18722 0.940870975705737 0.963797033632565 MAPK14 1 GO:0090329 regulation of DNA-dependent DNA replication 1/1115 46/18722 0.940870975705737 0.963797033632565 ATRX 1 GO:0002366 leukocyte activation involved in immune response 11/1115 275/18722 0.941556718806736 0.964314468004827 CD46/GRN/ANXA1/RPS6/CD74/RIF1/TFRC/FOXP1/HMGB1/ITFG2/RC3H1 11 GO:0050830 defense response to Gram-positive bacterium 3/1115 101/18722 0.944440339387741 0.967011133827337 RPL39/ADAM17/MR1 3 GO:0060294 cilium movement involved in cell motility 4/1115 125/18722 0.944551987808496 0.967011133827337 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0009123 nucleoside monophosphate metabolic process 2/1115 76/18722 0.945669417219923 0.967598508726939 DLG1/AK3 2 GO:0032543 mitochondrial translation 2/1115 76/18722 0.945669417219923 0.967598508726939 IARS2/LRPPRC 2 GO:0032720 negative regulation of tumor necrosis factor production 2/1115 76/18722 0.945669417219923 0.967598508726939 DICER1/GSTP1 2 GO:0007281 germ cell development 11/1115 278/18722 0.946359831280543 0.968119398200195 LGR5/RPS6/DIAPH2/DYNLL1/SMARCA2/HEXB/AFF4/ZFX/CELF1/PAQR7/CTNNB1 11 GO:0034308 primary alcohol metabolic process 3/1115 102/18722 0.946876437849324 0.968276824684455 ACSS1/REST/DHRS3 3 GO:1990542 mitochondrial transmembrane transport 3/1115 102/18722 0.946876437849324 0.968276824684455 VDAC1/SLC25A36/CPT2 3 GO:0030261 chromosome condensation 1/1115 48/18722 0.947720672620402 0.968954552110365 NUSAP1 1 GO:0032418 lysosome localization 2/1115 77/18722 0.94835894221779 0.969421480471143 TMEM106B/KIF5B 2 GO:0031497 chromatin assembly 5/1115 151/18722 0.950475960201909 0.970237320014338 NPM1/ATRX/RSF1/HMGB1/SHPRH 5 GO:0000959 mitochondrial RNA metabolic process 1/1115 49/18722 0.950842202556583 0.970237320014338 LRPPRC 1 GO:0030225 macrophage differentiation 1/1115 49/18722 0.950842202556583 0.970237320014338 APP 1 GO:0046605 regulation of centrosome cycle 1/1115 49/18722 0.950842202556583 0.970237320014338 NPM1 1 GO:0050832 defense response to fungus 1/1115 49/18722 0.950842202556583 0.970237320014338 GAPDH 1 GO:0051445 regulation of meiotic cell cycle 1/1115 49/18722 0.950842202556583 0.970237320014338 CDC20 1 GO:0070741 response to interleukin-6 1/1115 49/18722 0.950842202556583 0.970237320014338 IL6ST 1 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 2/1115 78/18722 0.950921193932106 0.970237320014338 PSAP/S1PR3 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 2/1115 78/18722 0.950921193932106 0.970237320014338 DICER1/GSTP1 2 GO:0006639 acylglycerol metabolic process 4/1115 128/18722 0.950974320216339 0.970237320014338 SEL1L/CAV1/CAT/GPAT4 4 GO:0090305 nucleic acid phosphodiester bond hydrolysis 10/1115 261/18722 0.952134465850615 0.970870945871501 N4BP2/DICER1/PLD3/RPS21/CNOT6L/XRN1/DCP2/AGO2/MOV10/SND1 10 GO:0006334 nucleosome assembly 4/1115 129/18722 0.952958426303162 0.970870945871501 NPM1/ATRX/RSF1/SHPRH 4 GO:0006638 neutral lipid metabolic process 4/1115 129/18722 0.952958426303162 0.970870945871501 SEL1L/CAV1/CAT/GPAT4 4 GO:0007127 meiosis I 4/1115 129/18722 0.952958426303162 0.970870945871501 TOP2B/SLC2A8/ATM/MLH3 4 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 2/1115 79/18722 0.953361775153659 0.970870945871501 GAPDH/RPL39 2 GO:0002448 mast cell mediated immunity 1/1115 50/18722 0.953777507229074 0.970870945871501 SERPINB9 1 GO:0010665 regulation of cardiac muscle cell apoptotic process 1/1115 50/18722 0.953777507229074 0.970870945871501 CFLAR 1 GO:0015872 dopamine transport 1/1115 50/18722 0.953777507229074 0.970870945871501 SYT7 1 GO:0042572 retinol metabolic process 1/1115 50/18722 0.953777507229074 0.970870945871501 DHRS3 1 GO:0046460 neutral lipid biosynthetic process 1/1115 50/18722 0.953777507229074 0.970870945871501 GPAT4 1 GO:0046463 acylglycerol biosynthetic process 1/1115 50/18722 0.953777507229074 0.970870945871501 GPAT4 1 GO:0099054 presynapse assembly 1/1115 50/18722 0.953777507229074 0.970870945871501 APP 1 GO:0120254 olefinic compound metabolic process 5/1115 153/18722 0.954140269653462 0.971055070468897 PTGES3/GSTP1/REST/DHRS3/ELOVL1 5 GO:0071219 cellular response to molecule of bacterial origin 8/1115 221/18722 0.956035341503593 0.97279830156045 ABCA1/TFPI/GSTP1/FZD5/HMGB1/MAPK14/EDNRB/RHOA 8 GO:1903307 positive regulation of regulated secretory pathway 1/1115 51/18722 0.956537687147646 0.973123992317317 SYT7 1 GO:0008637 apoptotic mitochondrial changes 3/1115 107/18722 0.95763298352532 0.974052676517752 IFI6/SLC35F6/HSPA1A 3 GO:0007129 homologous chromosome pairing at meiosis 1/1115 52/18722 0.959133181702323 0.97539277278261 MLH3 1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 2/1115 82/18722 0.960006330427071 0.976094800637999 CFLAR/FEM1B 2 GO:0033059 cellular pigmentation 1/1115 53/18722 0.961573808504782 0.977130293796542 MYO7A 1 GO:0043113 receptor clustering 1/1115 53/18722 0.961573808504782 0.977130293796542 DLG1 1 GO:0099172 presynapse organization 1/1115 53/18722 0.961573808504782 0.977130293796542 APP 1 GO:0061982 meiosis I cell cycle process 4/1115 135/18722 0.963388996753085 0.978212149764929 TOP2B/SLC2A8/ATM/MLH3 4 GO:0051260 protein homooligomerization 6/1115 182/18722 0.96358944300607 0.978212149764929 MIF/ALDOA/SLC1A5/RNF213/PKD2/FUS 6 GO:0046488 phosphatidylinositol metabolic process 5/1115 159/18722 0.963698798500578 0.978212149764929 PGAP1/CDS1/SMG1/GPAA1/ATM 5 GO:0006584 catecholamine metabolic process 1/1115 54/18722 0.963868800390645 0.978212149764929 LY6E 1 GO:0009712 catechol-containing compound metabolic process 1/1115 54/18722 0.963868800390645 0.978212149764929 LY6E 1 GO:0010659 cardiac muscle cell apoptotic process 1/1115 54/18722 0.963868800390645 0.978212149764929 CFLAR 1 GO:0010660 regulation of muscle cell apoptotic process 2/1115 84/18722 0.963920981440961 0.978212149764929 BMP7/CFLAR 2 GO:0044282 small molecule catabolic process 15/1115 376/18722 0.965228869589897 0.979353275321258 LRP5/GLDC/SLC27A2/ATP2B4/GLB1/ENO1/TPI1/CROT/ECHDC2/CPT2/ABCD3/ACOX1/ALDH4A1/BCAT2/MGAT1 15 GO:0046164 alcohol catabolic process 1/1115 55/18722 0.966026840221608 0.97997668628979 TPI1 1 GO:0045055 regulated exocytosis 8/1115 230/18722 0.967481533962448 0.980916964097021 SCIN/CALM1/ATP2A2/SYT7/RAB3GAP1/RAB31/REST/SYNGR2 8 GO:0001539 cilium or flagellum-dependent cell motility 4/1115 138/18722 0.967757890905637 0.980916964097021 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0060285 cilium-dependent cell motility 4/1115 138/18722 0.967757890905637 0.980916964097021 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0001578 microtubule bundle formation 3/1115 113/18722 0.967844256766392 0.980916964097021 CLIP1/ZNF207/CAPN6 3 GO:0050433 regulation of catecholamine secretion 1/1115 56/18722 0.968056093618132 0.980916964097021 SYT7 1 GO:0098781 ncRNA transcription 1/1115 56/18722 0.968056093618132 0.980916964097021 NCL 1 GO:0071222 cellular response to lipopolysaccharide 7/1115 209/18722 0.96891592376647 0.981601919732292 ABCA1/TFPI/GSTP1/HMGB1/MAPK14/EDNRB/RHOA 7 GO:1902017 regulation of cilium assembly 1/1115 57/18722 0.969964239745625 0.982477532916314 CDKL5 1 GO:0010657 muscle cell apoptotic process 2/1115 89/18722 0.972161934040282 0.984516799287 BMP7/CFLAR 2 GO:0001836 release of cytochrome c from mitochondria 1/1115 59/18722 0.973445666589939 0.985201882336885 IFI6 1 GO:0019369 arachidonic acid metabolic process 1/1115 59/18722 0.973445666589939 0.985201882336885 PTGES3 1 GO:0035278 miRNA mediated inhibition of translation 2/1115 90/18722 0.973576537031167 0.985201882336885 TNRC6B/AGO2 2 GO:0040033 negative regulation of translation, ncRNA-mediated 2/1115 90/18722 0.973576537031167 0.985201882336885 TNRC6B/AGO2 2 GO:0002275 myeloid cell activation involved in immune response 2/1115 91/18722 0.974921582333052 0.985740677483614 GRN/HMGB1 2 GO:0045974 regulation of translation, ncRNA-mediated 2/1115 91/18722 0.974921582333052 0.985740677483614 TNRC6B/AGO2 2 GO:0009620 response to fungus 1/1115 60/18722 0.975032125452513 0.985740677483614 GAPDH 1 GO:0019731 antibacterial humoral response 1/1115 60/18722 0.975032125452513 0.985740677483614 RPL39 1 GO:0031663 lipopolysaccharide-mediated signaling pathway 1/1115 60/18722 0.975032125452513 0.985740677483614 MAPK14 1 GO:0050994 regulation of lipid catabolic process 1/1115 61/18722 0.97652388304122 0.987061910556053 IDH1 1 GO:0045132 meiotic chromosome segregation 2/1115 93/18722 0.977415890897184 0.987776536342999 TOP2B/MLH3 2 GO:0002449 lymphocyte mediated immunity 13/1115 350/18722 0.977750407235793 0.987918647375371 CD46/PRDX1/CTSC/CD74/RIF1/JAG1/TFRC/FZD5/KIF5B/HMGB1/SERPINB9/MR1/CADM1 13 GO:0009116 nucleoside metabolic process 1/1115 62/18722 0.97792658763417 0.987918647375371 ERH 1 GO:0045143 homologous chromosome segregation 1/1115 63/18722 0.979245550913264 0.989063941794536 MLH3 1 GO:0002253 activation of immune response 14/1115 375/18722 0.980117630666503 0.989757524140053 CD46/SLC39A10/PRKDC/RPS3/KCNN4/CD47/WNK1/VAV3/FOXP1/HMGB1/APPL1/MAVS/RC3H1/CREBBP 14 GO:0006323 DNA packaging 6/1115 199/18722 0.980927489907066 0.990183201981768 NPM1/ATRX/RSF1/HMGB1/SHPRH/NUSAP1 6 GO:0002443 leukocyte mediated immunity 17/1115 440/18722 0.981282675709872 0.990183201981768 CD46/PRDX1/CTSC/CD74/RIF1/JAG1/TFRC/FZD5/KIF5B/ADAM17/DHX36/HMGB1/TLR3/MAVS/SERPINB9/MR1/CADM1 17 GO:0002429 immune response-activating cell surface receptor signaling pathway 10/1115 291/18722 0.981511835916882 0.990183201981768 SLC39A10/RPS3/KCNN4/CD47/WNK1/VAV3/FOXP1/APPL1/RC3H1/CREBBP 10 GO:0002757 immune response-activating signal transduction 10/1115 291/18722 0.981511835916882 0.990183201981768 SLC39A10/RPS3/KCNN4/CD47/WNK1/VAV3/FOXP1/APPL1/RC3H1/CREBBP 10 GO:0006261 DNA-dependent DNA replication 4/1115 151/18722 0.981636853776419 0.990183201981768 BOD1L1/ATRX/REV3L/RRM2B 4 GO:0061512 protein localization to cilium 1/1115 65/18722 0.981651936334426 0.990183201981768 ARF4 1 GO:2000272 negative regulation of signaling receptor activity 1/1115 66/18722 0.982748473343972 0.991102021001789 LY6E 1 GO:1903046 meiotic cell cycle process 6/1115 202/18722 0.983039398931882 0.991208187138304 ATRX/TOP2B/SLC2A8/ATM/CDC20/MLH3 6 GO:0007631 feeding behavior 2/1115 99/18722 0.983540523039847 0.991526218374197 APP/UBR3 2 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/1115 67/18722 0.983779533175741 0.991579937252271 ANXA1 1 GO:0050853 B cell receptor signaling pathway 3/1115 131/18722 0.986280196585165 0.993912791537976 SLC39A10/VAV3/FOXP1 3 GO:0140013 meiotic nuclear division 5/1115 185/18722 0.987440430713975 0.99489421769804 TOP2B/SLC2A8/ATM/CDC20/MLH3 5 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3/1115 134/18722 0.988133337170568 0.995404507010125 MET/ATP2B4/ROCK1 3 GO:0010822 positive regulation of mitochondrion organization 1/1115 74/18722 0.989464076390777 0.996557008838022 VDAC1 1 GO:0140053 mitochondrial gene expression 2/1115 108/18722 0.989813031297799 0.996720440229903 IARS2/LRPPRC 2 GO:0007286 spermatid development 4/1115 165/18722 0.990182672259133 0.996758516181583 DYNLL1/SMARCA2/AFF4/CELF1 4 GO:0050851 antigen receptor-mediated signaling pathway 7/1115 240/18722 0.990224231097044 0.996758516181583 SLC39A10/RPS3/KCNN4/WNK1/VAV3/FOXP1/RC3H1 7 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 12/1115 356/18722 0.990668132628702 0.996847817276723 CD46/ANXA1/CTSC/CD74/RIF1/JAG1/TFRC/FZD5/ADAM17/HMGB1/RC3H1/MR1 12 GO:0140029 exocytic process 1/1115 76/18722 0.990686367947236 0.996847817276723 RAB13 1 GO:0009451 RNA modification 4/1115 167/18722 0.991036427302718 0.997012151002301 RBM47/ZC3H13/RNMT/TARBP1 4 GO:0006805 xenobiotic metabolic process 2/1115 111/18722 0.99132970976924 0.997119314328932 GSTP1/NCEH1 2 GO:1901616 organic hydroxy compound catabolic process 1/1115 78/18722 0.991766971575405 0.997279331632592 TPI1 1 GO:0002768 immune response-regulating cell surface receptor signaling pathway 10/1115 315/18722 0.991862380777124 0.997279331632592 SLC39A10/RPS3/KCNN4/CD47/WNK1/VAV3/FOXP1/APPL1/RC3H1/CREBBP 10 GO:0048515 spermatid differentiation 4/1115 172/18722 0.992871022463067 0.998105514767523 DYNLL1/SMARCA2/AFF4/CELF1 4 GO:0003341 cilium movement 4/1115 175/18722 0.993792625363995 0.998843905651048 ATP2B4/ASH1L/VPS13A/DNAJA1 4 GO:0019730 antimicrobial humoral response 2/1115 122/18722 0.995222365809087 0.999864368527398 GAPDH/RPL39 2 GO:0002440 production of molecular mediator of immune response 9/1115 308/18722 0.995503717031059 0.999864368527398 CD74/PRKDC/RIF1/TFRC/FZD5/DHX36/SEMA7A/TLR3/MAVS 9 GO:0050829 defense response to Gram-negative bacterium 1/1115 88/18722 0.995557029985325 0.999864368527398 MR1 1 GO:0070098 chemokine-mediated signaling pathway 1/1115 88/18722 0.995557029985325 0.999864368527398 WNK1 1 GO:0006400 tRNA modification 1/1115 90/18722 0.996072842295721 0.999949446848519 TARBP1 1 GO:1903351 cellular response to dopamine 1/1115 92/18722 0.996528818145487 0.999949446848519 NCSTN 1 GO:0007601 visual perception 5/1115 215/18722 0.996597122678964 0.999949446848519 EFEMP1/ATF6/MYO7A/DHRS3/WFS1 5 GO:1903350 response to dopamine 1/1115 93/18722 0.996736567354708 0.999949446848519 NCSTN 1 GO:0050953 sensory perception of light stimulus 5/1115 219/18722 0.997156642886811 0.999949446848519 EFEMP1/ATF6/MYO7A/DHRS3/WFS1 5 GO:0044782 cilium organization 11/1115 368/18722 0.99720424974734 0.999949446848519 LAMA5/GALNT11/DYNLL1/CEP350/CDKL5/PCM1/TTC17/AHI1/ASAP1/PKD2/ARF4 11 GO:0042742 defense response to bacterium 10/1115 350/18722 0.997732939978628 0.999949446848519 GRN/COLEC12/RPL39/RBPJ/ADAM17/FOXP1/TLR3/ANKRD17/MAVS/MR1 10 GO:0006910 phagocytosis, recognition 1/1115 100/18722 0.997881570101637 0.999949446848519 COLEC12 1 GO:0034754 cellular hormone metabolic process 2/1115 137/18722 0.997903031941707 0.999949446848519 REST/DHRS3 2 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1/1115 104/18722 0.998345195009963 0.999949446848519 EDNRB 1 GO:0060271 cilium assembly 9/1115 337/18722 0.998534845986656 0.999949446848519 LAMA5/GALNT11/DYNLL1/CEP350/CDKL5/PCM1/AHI1/ASAP1/ARF4 9 GO:0007218 neuropeptide signaling pathway 1/1115 106/18722 0.998537471730469 0.999949446848519 RAPGEF2 1 GO:0051321 meiotic cell cycle 6/1115 261/18722 0.998565375132888 0.999949446848519 ATRX/TOP2B/SLC2A8/ATM/CDC20/MLH3 6 GO:0016064 immunoglobulin mediated immune response 4/1115 207/18722 0.998641134816517 0.999949446848519 CD46/CD74/RIF1/TFRC 4 GO:0006958 complement activation, classical pathway 1/1115 108/18722 0.998707424939903 0.999949446848519 CD46 1 GO:0006399 tRNA metabolic process 3/1115 179/18722 0.998761566240409 0.999949446848519 DICER1/IARS2/TARBP1 3 GO:0019724 B cell mediated immunity 4/1115 210/18722 0.998825697704281 0.999949446848519 CD46/CD74/RIF1/TFRC 4 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/1115 121/18722 0.999421110675205 0.999999999773153 CD46 1 GO:0008033 tRNA processing 1/1115 127/18722 0.99960051700949 0.999999999773153 TARBP1 1 GO:0006956 complement activation 1/1115 130/18722 0.999668159369872 0.999999999773153 CD46 1 GO:0002377 immunoglobulin production 3/1115 216/18722 0.999823101032704 0.999999999773153 PRKDC/RIF1/TFRC 3 GO:0006959 humoral immune response 4/1115 317/18722 0.999995148845892 0.999999999773153 GAPDH/CD46/RPL39/RBPJ 4 GO:0007608 sensory perception of smell 3/1115 456/18722 0.999999999773153 0.999999999773153 B3GNT2/NAV2/UBR3 3