ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0010038 response to metal ion 15/147 373/18722 2.5429786969245e-07 0.000760604928250119 PLSCR1/PPARGC1A/S100A16/SNCA/MT1A/SHH/SLC30A1/ALAD/MT1X/PRKAA2/FOS/NDRG1/GCLC/SOD2/HIF1A 15 GO:0060070 canonical Wnt signaling pathway 13/147 303/18722 8.09616049210863e-07 0.000774255285053229 SHH/FZD8/STK4/MCC/TPBG/BCL9L/SMAD3/BICC1/IGFBP4/DLX5/IGFBP6/DAB2/DKK1 13 GO:0030178 negative regulation of Wnt signaling pathway 10/147 170/18722 9.52109590401485e-07 0.000774255285053229 SHH/STK4/MCC/TPBG/TSKU/BICC1/IGFBP4/IGFBP6/DAB2/DKK1 10 GO:0046686 response to cadmium ion 7/147 68/18722 1.03544672023167e-06 0.000774255285053229 MT1A/SLC30A1/ALAD/MT1X/FOS/GCLC/SOD2 7 GO:0090090 negative regulation of canonical Wnt signaling pathway 9/147 137/18722 1.35382556867785e-06 0.000809858455183089 SHH/STK4/MCC/TPBG/BICC1/IGFBP4/IGFBP6/DAB2/DKK1 9 GO:0016055 Wnt signaling pathway 15/147 444/18722 2.260816934199e-06 0.0010207541679861 SHH/FZD8/STK4/MCC/TPBG/PRKAA2/BCL9L/TSKU/SMAD3/BICC1/IGFBP4/DLX5/IGFBP6/DAB2/DKK1 15 GO:0198738 cell-cell signaling by wnt 15/147 446/18722 2.38892650481534e-06 0.0010207541679861 SHH/FZD8/STK4/MCC/TPBG/PRKAA2/BCL9L/TSKU/SMAD3/BICC1/IGFBP4/DLX5/IGFBP6/DAB2/DKK1 15 GO:0060828 regulation of canonical Wnt signaling pathway 11/147 253/18722 5.18056284314411e-06 0.0019368829329805 SHH/STK4/MCC/TPBG/SMAD3/BICC1/IGFBP4/DLX5/IGFBP6/DAB2/DKK1 11 GO:0030111 regulation of Wnt signaling pathway 12/147 328/18722 1.10840479998304e-05 0.00368359861861032 SHH/STK4/MCC/TPBG/TSKU/SMAD3/BICC1/IGFBP4/DLX5/IGFBP6/DAB2/DKK1 12 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 12/147 355/18722 2.42847533782745e-05 0.00674118093537023 ATOH8/SHH/HSPA1A/HTRA3/FOS/BCL9L/PMEPA1/TOB1/SMAD3/DLX5/DAB2/DKK1 12 GO:2001233 regulation of apoptotic signaling pathway 12/147 356/18722 2.49644000267638e-05 0.00674118093537023 BDKRB2/PPP2R1B/DEPTOR/HSPA1A/STK4/CTSH/SRPX/HSPA1B/GCLC/PIH1D1/SOD2/HIF1A 12 GO:0045913 positive regulation of carbohydrate metabolic process 6/147 75/18722 2.7271912850967e-05 0.00674118093537023 PPARGC1A/SNCA/NNMT/PRKAA2/IRS2/HIF1A 6 GO:0014823 response to activity 6/147 76/18722 2.94195634384431e-05 0.00674118093537023 PPARGC1A/ALAD/PRKAA2/GCLC/SOD2/HIF1A 6 GO:0001666 response to hypoxia 11/147 307/18722 3.15535048797002e-05 0.00674118093537023 PPARGC1A/AK4/ALAD/NDRG1/VEGFA/ALKBH5/PLAT/SMAD3/MYC/SOD2/HIF1A 11 GO:0036293 response to decreased oxygen levels 11/147 322/18722 4.86607906486074e-05 0.00970296165533232 PPARGC1A/AK4/ALAD/NDRG1/VEGFA/ALKBH5/PLAT/SMAD3/MYC/SOD2/HIF1A 11 GO:0034284 response to monosaccharide 9/147 225/18722 7.3039745614226e-05 0.0136538674457594 PPARGC1A/PRKAA2/IRS2/GJA1/SLC39A14/GCLC/PIH1D1/SOD2/HIF1A 9 GO:0010043 response to zinc ion 5/147 58/18722 9.13744190843758e-05 0.0157749964359115 MT1A/SLC30A1/ALAD/MT1X/SOD2 5 GO:0070482 response to oxygen levels 11/147 347/18722 9.49347829643622e-05 0.0157749964359115 PPARGC1A/AK4/ALAD/NDRG1/VEGFA/ALKBH5/PLAT/SMAD3/MYC/SOD2/HIF1A 11 GO:0055076 transition metal ion homeostasis 7/147 138/18722 0.000109588848694102 0.0172515919181083 MT1A/SLC25A37/SLC30A1/MT1X/SLC39A14/MYC/HIF1A 7 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 3/147 13/18722 0.000128034484350411 0.0176884798346557 SLC15A4/HSPA1A/HSPA1B 3 GO:0009896 positive regulation of catabolic process 13/147 492/18722 0.000137893402246864 0.0176884798346557 SNCA/HSPA1A/PSMC4/PRKAA2/IRS2/GJA1/TOB1/C4BPA/YTHDF2/HSPA1B/GCLC/DAB2/HIF1A 13 GO:0043524 negative regulation of neuron apoptotic process 7/147 145/18722 0.000149175062890217 0.0176884798346557 PPARGC1A/SNCA/DNAJC5/GCLC/SOD2/HIF1A/CEBPB 7 GO:0035672 oligopeptide transmembrane transport 3/147 14/18722 0.000162016077068426 0.0176884798346557 SLC15A4/SLC15A1/GJA1 3 GO:0071248 cellular response to metal ion 8/147 197/18722 0.000166846588099326 0.0176884798346557 PPARGC1A/SNCA/MT1A/SHH/ALAD/MT1X/PRKAA2/FOS 8 GO:0050673 epithelial cell proliferation 12/147 437/18722 0.000176105732627039 0.0176884798346557 ATOH8/SHH/B4GALT1/MCC/VEGFA/GJA1/SMAD3/MYC/IGFBP4/DLX5/HIF1A/CEBPB 12 GO:0009743 response to carbohydrate 9/147 253/18722 0.000177601142467167 0.0176884798346557 PPARGC1A/PRKAA2/IRS2/GJA1/SLC39A14/GCLC/PIH1D1/SOD2/HIF1A 9 GO:0045936 negative regulation of phosphate metabolic process 12/147 441/18722 0.000191539356619852 0.0176884798346557 SOCS1/BDKRB2/PPARGC1A/DEPTOR/SNCA/PPP1R15A/SH3BP5/HEXIM1/PMEPA1/IRS2/SOCS3/DKK1 12 GO:0071333 cellular response to glucose stimulus 7/147 151/18722 0.000191683436302189 0.0176884798346557 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:2001236 regulation of extrinsic apoptotic signaling pathway 7/147 151/18722 0.000191683436302189 0.0176884798346557 PPP2R1B/DEPTOR/HSPA1A/STK4/SRPX/HSPA1B/GCLC 7 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9/147 256/18722 0.000193931843322239 0.0176884798346557 SHH/HSPA1A/HTRA3/BCL9L/PMEPA1/TOB1/SMAD3/DAB2/DKK1 9 GO:0010563 negative regulation of phosphorus metabolic process 12/147 442/18722 0.000195573596982268 0.0176884798346557 SOCS1/BDKRB2/PPARGC1A/DEPTOR/SNCA/PPP1R15A/SH3BP5/HEXIM1/PMEPA1/IRS2/SOCS3/DKK1 12 GO:0071542 dopaminergic neuron differentiation 4/147 37/18722 0.000196976479441295 0.0176884798346557 SHH/VEGFA/HIF1A/DKK1 4 GO:1990822 basic amino acid transmembrane transport 3/147 15/18722 0.000201356109946703 0.0176884798346557 SLC15A4/SLC7A2/SLC25A29 3 GO:0071331 cellular response to hexose stimulus 7/147 153/18722 0.000207850380787953 0.0176884798346557 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:0071326 cellular response to monosaccharide stimulus 7/147 154/18722 0.000216336894455017 0.0176884798346557 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:1901214 regulation of neuron death 10/147 319/18722 0.000217168436476209 0.0176884798346557 PPARGC1A/SNCA/DNAJC5/HLA-F/FOS/GCLC/SOD2/HIF1A/CEBPB/DKK1 10 GO:0006882 cellular zinc ion homeostasis 4/147 38/18722 0.000218814361043886 0.0176884798346557 MT1A/SLC30A1/MT1X/SLC39A14 4 GO:0042326 negative regulation of phosphorylation 11/147 385/18722 0.000234844032259469 0.0179751105302879 SOCS1/BDKRB2/PPARGC1A/DEPTOR/SNCA/SH3BP5/HEXIM1/PMEPA1/IRS2/SOCS3/DKK1 11 GO:1901215 negative regulation of neuron death 8/147 208/18722 0.000241590818322371 0.0179751105302879 PPARGC1A/SNCA/DNAJC5/HLA-F/GCLC/SOD2/HIF1A/CEBPB 8 GO:0006857 oligopeptide transport 3/147 16/18722 0.000246399041037045 0.0179751105302879 SLC15A4/SLC15A1/GJA1 3 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 3/147 16/18722 0.000246399041037045 0.0179751105302879 SLC15A4/HSPA1A/HSPA1B 3 GO:0055069 zinc ion homeostasis 4/147 40/18722 0.000267636425260509 0.0186470510560321 MT1A/SLC30A1/MT1X/SLC39A14 4 GO:0042176 regulation of protein catabolic process 11/147 391/18722 0.000268078634372913 0.0186470510560321 SNCA/SHH/HSPA1A/PSMC4/ALAD/GJA1/C4BPA/HSPA1B/SMAD3/GCLC/DAB2 11 GO:0009749 response to glucose 8/147 212/18722 0.000274784179961816 0.0186790791424043 PPARGC1A/PRKAA2/IRS2/GJA1/SLC39A14/GCLC/PIH1D1/HIF1A 8 GO:0046916 cellular transition metal ion homeostasis 6/147 115/18722 0.000294754475520222 0.0193426928608705 MT1A/SLC30A1/MT1X/SLC39A14/MYC/HIF1A 6 GO:0097067 cellular response to thyroid hormone stimulus 3/147 17/18722 0.0002974803983952 0.0193426928608705 PPARGC1A/CTSH/GCLC 3 GO:0071322 cellular response to carbohydrate stimulus 7/147 163/18722 0.000306026312837014 0.0194749936530959 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/147 42/18722 0.000323825320085488 0.0201783652578269 ATOH8/FOS/SMAD3/HIF1A 4 GO:0009746 response to hexose 8/147 219/18722 0.000341816732697028 0.0204151235114724 PPARGC1A/PRKAA2/IRS2/GJA1/SLC39A14/GCLC/PIH1D1/HIF1A 8 GO:0097191 extrinsic apoptotic signaling pathway 8/147 219/18722 0.000341816732697028 0.0204151235114724 PPP2R1B/DEPTOR/HSPA1A/STK4/SRPX/HSPA1B/SMAD3/GCLC 8 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/147 43/18722 0.000354874208728485 0.0204151235114724 PPP2R1B/HSPA1A/SRPX/HSPA1B 4 GO:0061687 detoxification of inorganic compound 3/147 18/18722 0.000354926921630414 0.0204151235114724 MT1A/SLC30A1/MT1X 3 GO:2000241 regulation of reproductive process 7/147 168/18722 0.00036746540599991 0.0207375288555798 SHH/B4GALT1/STK4/VEGFA/GJA1/PLAT/YTHDF2 7 GO:0001933 negative regulation of protein phosphorylation 10/147 342/18722 0.000377607060677633 0.0209152355275333 SOCS1/BDKRB2/PPARGC1A/DEPTOR/SNCA/SH3BP5/HEXIM1/PMEPA1/SOCS3/DKK1 10 GO:0015802 basic amino acid transport 3/147 19/18722 0.000419056701632084 0.0218351163526459 SLC15A4/SLC7A2/SLC25A29 3 GO:0097501 stress response to metal ion 3/147 19/18722 0.000419056701632084 0.0218351163526459 MT1A/SLC30A1/MT1X 3 GO:0071241 cellular response to inorganic substance 8/147 226/18722 0.000421632860341209 0.0218351163526459 PPARGC1A/SNCA/MT1A/SHH/ALAD/MT1X/PRKAA2/FOS 8 GO:0001678 cellular glucose homeostasis 7/147 172/18722 0.000423415830308747 0.0218351163526459 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:0060395 SMAD protein signal transduction 5/147 82/18722 0.000467952377920787 0.0237228061417131 ATOH8/FOS/TOB1/SMAD3/DAB2 5 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 4/147 47/18722 0.000500586271304709 0.0248237386767574 HSPA1A/VEGFA/HIF1A/CEBPB 4 GO:0006109 regulation of carbohydrate metabolic process 7/147 178/18722 0.000519911320006404 0.0248237386767574 PPARGC1A/SNCA/NNMT/PRKAA2/IRS2/IGFBP4/HIF1A 7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 6/147 128/18722 0.000522774009458716 0.0248237386767574 HSPA1A/HTRA3/BCL9L/PMEPA1/SMAD3/DAB2 6 GO:1900542 regulation of purine nucleotide metabolic process 5/147 84/18722 0.000522867113552563 0.0248237386767574 PPARGC1A/SNCA/AK4/PRKAA2/HIF1A 5 GO:0031331 positive regulation of cellular catabolic process 11/147 427/18722 0.000562517040363625 0.0248945541557313 SNCA/HSPA1A/PSMC4/PRKAA2/IRS2/TOB1/YTHDF2/HSPA1B/GCLC/DAB2/HIF1A 11 GO:0043467 regulation of generation of precursor metabolites and energy 6/147 130/18722 0.000567496384568802 0.0248945541557313 PPARGC1A/SNCA/AK4/PRKAA2/IRS2/HIF1A 6 GO:0070997 neuron death 10/147 361/18722 0.00057566904679908 0.0248945541557313 PPARGC1A/SNCA/DNAJC5/HLA-F/FOS/GCLC/SOD2/HIF1A/CEBPB/DKK1 10 GO:0006140 regulation of nucleotide metabolic process 5/147 86/18722 0.000582491283544964 0.0248945541557313 PPARGC1A/SNCA/AK4/PRKAA2/HIF1A 5 GO:0043457 regulation of cellular respiration 4/147 49/18722 0.000587458680903047 0.0248945541557313 PPARGC1A/SNCA/AK4/HIF1A 4 GO:0031647 regulation of protein stability 9/147 298/18722 0.00058853503779327 0.0248945541557313 PPARGC1A/SNCA/HSPA1A/CCNH/IFT46/STK4/CTSH/HSPA1B/SMAD3 9 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 6/147 131/18722 0.000590943946859552 0.0248945541557313 HSPA1A/HTRA3/BCL9L/PMEPA1/TOB1/DKK1 6 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 6/147 131/18722 0.000590943946859552 0.0248945541557313 HSPA1A/HTRA3/BCL9L/PMEPA1/SMAD3/DAB2 6 GO:1903578 regulation of ATP metabolic process 5/147 87/18722 0.000614148443148073 0.0255127499091096 PPARGC1A/SNCA/AK4/PRKAA2/HIF1A 5 GO:0001961 positive regulation of cytokine-mediated signaling pathway 4/147 50/18722 0.000634678152161758 0.0257450542149804 HSPA1A/PARP9/HSPA1B/HIF1A 4 GO:0001701 in utero embryonic development 10/147 367/18722 0.000653706971480943 0.0257450542149804 PSMC4/ATP11A/STK4/SLC30A1/VEGFA/MAFF/SMAD3/HIF1A/CEBPB/SOCS3 10 GO:0002053 positive regulation of mesenchymal cell proliferation 3/147 22/18722 0.0006545996442982 0.0257450542149804 SHH/IRS2/MYC 3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 3/147 22/18722 0.0006545996442982 0.0257450542149804 VEGFA/DLX5/HIF1A 3 GO:0015849 organic acid transport 9/147 303/18722 0.000662778059028249 0.0257450542149804 BDKRB2/SNCA/SLC15A4/PLIN2/IRS2/GJA1/SLC7A2/SLC25A29/TRPC4 9 GO:0001101 response to acid chemical 6/147 135/18722 0.000692352637521596 0.0263781826081178 SOCS1/PPARGC1A/ALAD/VEGFA/GCLC/CEBPB 6 GO:0061136 regulation of proteasomal protein catabolic process 7/147 187/18722 0.000696715622213743 0.0263781826081178 SHH/HSPA1A/PSMC4/ALAD/HSPA1B/GCLC/DAB2 7 GO:0046031 ADP metabolic process 5/147 90/18722 0.000716886583335062 0.0268025971344396 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0002052 positive regulation of neuroblast proliferation 3/147 23/18722 0.000748475175954375 0.0273010884302382 SHH/VEGFA/HIF1A 3 GO:0035162 embryonic hemopoiesis 3/147 23/18722 0.000748475175954375 0.0273010884302382 STK4/VEGFA/HIF1A 3 GO:0050821 protein stabilization 7/147 191/18722 0.0007891916684069 0.0280352762085453 PPARGC1A/HSPA1A/CCNH/IFT46/STK4/HSPA1B/SMAD3 7 GO:0043620 regulation of DNA-templated transcription in response to stress 4/147 53/18722 0.000792434909671466 0.0280352762085453 HSPA1A/VEGFA/HIF1A/CEBPB 4 GO:0045926 negative regulation of growth 8/147 249/18722 0.000796722994893465 0.0280352762085453 MT1A/HSPA1A/STK4/MT1X/GJA1/HSPA1B/SMAD3/HIF1A 8 GO:0071560 cellular response to transforming growth factor beta stimulus 8/147 250/18722 0.000817691239161477 0.028438540655023 PPARGC1A/HSPA1A/HTRA3/FOS/BCL9L/PMEPA1/SMAD3/DAB2 8 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 3/147 24/18722 0.000850499453461565 0.0289126305863525 VEGFA/HIF1A/CEBPB 3 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 4/147 54/18722 0.000850655797926785 0.0289126305863525 ATOH8/FOS/SMAD3/HIF1A 4 GO:0050678 regulation of epithelial cell proliferation 10/147 381/18722 0.000870280565298732 0.0292472940540282 ATOH8/SHH/B4GALT1/MCC/VEGFA/GJA1/SMAD3/MYC/DLX5/HIF1A 10 GO:0007009 plasma membrane organization 6/147 142/18722 0.00090171670388573 0.0296443611089825 PLSCR1/NDRG1/MYOF/PACSIN2/DMKN/EPB41L3 6 GO:0010676 positive regulation of cellular carbohydrate metabolic process 4/147 55/18722 0.000911829228360544 0.0296443611089825 PPARGC1A/SNCA/NNMT/IRS2 4 GO:0061614 pri-miRNA transcription by RNA polymerase II 4/147 55/18722 0.000911829228360544 0.0296443611089825 ATOH8/FOS/SMAD3/HIF1A 4 GO:0006865 amino acid transport 6/147 143/18722 0.000935214900490032 0.029732089118466 SNCA/SLC15A4/GJA1/SLC7A2/SLC25A29/TRPC4 6 GO:0062013 positive regulation of small molecule metabolic process 6/147 143/18722 0.000935214900490032 0.029732089118466 PPARGC1A/SNCA/NNMT/PRKAA2/IRS2/HIF1A 6 GO:0071559 response to transforming growth factor beta 8/147 256/18722 0.000953015858281404 0.029732089118466 PPARGC1A/HSPA1A/HTRA3/FOS/BCL9L/PMEPA1/SMAD3/DAB2 8 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3/147 25/18722 0.000960941510163895 0.029732089118466 SLC15A4/HSPA1A/HSPA1B 3 GO:0001890 placenta development 6/147 144/18722 0.00096966336385001 0.029732089118466 STK4/GJA1/MAP3K4/HIF1A/CEBPB/SOCS3 6 GO:0007179 transforming growth factor beta receptor signaling pathway 7/147 198/18722 0.000974170756806977 0.029732089118466 HSPA1A/HTRA3/FOS/BCL9L/PMEPA1/SMAD3/DAB2 7 GO:0060760 positive regulation of response to cytokine stimulus 4/147 57/18722 0.00104335786938943 0.0313637613050876 HSPA1A/PARP9/HSPA1B/HIF1A 4 GO:0009410 response to xenobiotic stimulus 11/147 462/18722 0.00107065578515819 0.0313637613050876 PPARGC1A/SNCA/AK4/ALAD/NNMT/PRKAA2/PLIN2/FOS/MYC/GCLC/SOD2 11 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 3/147 26/18722 0.00108006265945303 0.0313637613050876 SLC15A4/HSPA1A/HSPA1B 3 GO:0046639 negative regulation of alpha-beta T cell differentiation 3/147 26/18722 0.00108006265945303 0.0313637613050876 SOCS1/SHH/CBFB 3 GO:0097066 response to thyroid hormone 3/147 26/18722 0.00108006265945303 0.0313637613050876 PPARGC1A/CTSH/GCLC 3 GO:0006165 nucleoside diphosphate phosphorylation 5/147 99/18722 0.00110276761883669 0.0317151725763513 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0032869 cellular response to insulin stimulus 7/147 203/18722 0.00112602749876336 0.0319871749522701 SOCS1/LPIN3/IRS2/SLC39A14/GCLC/PKM/SOCS3 7 GO:0002831 regulation of response to biotic stimulus 9/147 327/18722 0.00113361435805437 0.0319871749522701 SOCS1/PLSCR1/SLC15A4/HLA-F/HEXIM1/IFIT1/PARP9/CD55/YTHDF2 9 GO:0001959 regulation of cytokine-mediated signaling pathway 6/147 150/18722 0.00119732921216562 0.0331511634160009 SOCS1/HSPA1A/PARP9/YTHDF2/HSPA1B/HIF1A 6 GO:0046939 nucleotide phosphorylation 5/147 101/18722 0.00120608967141622 0.0331511634160009 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0014850 response to muscle activity 3/147 27/18722 0.0012081166206433 0.0331511634160009 PPARGC1A/PRKAA2/HIF1A 3 GO:0071456 cellular response to hypoxia 6/147 151/18722 0.00123894214082204 0.0336879631199883 PPARGC1A/AK4/NDRG1/VEGFA/MYC/HIF1A 6 GO:0009135 purine nucleoside diphosphate metabolic process 5/147 103/18722 0.00131640658928702 0.0351551081121204 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0009179 purine ribonucleoside diphosphate metabolic process 5/147 103/18722 0.00131640658928702 0.0351551081121204 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0010464 regulation of mesenchymal cell proliferation 3/147 28/18722 0.00134534964320354 0.0352977261651034 SHH/IRS2/MYC 3 GO:0071280 cellular response to copper ion 3/147 28/18722 0.00134534964320354 0.0352977261651034 SNCA/MT1A/MT1X 3 GO:0062197 cellular response to chemical stress 9/147 337/18722 0.00139651492370688 0.036321531624411 BDKRB2/PPARGC1A/SNCA/HSPA1A/PRKAA2/FOS/HSPA1B/SOD2/HIF1A 9 GO:0043523 regulation of neuron apoptotic process 7/147 212/18722 0.00144570881669122 0.0372768540579606 PPARGC1A/SNCA/DNAJC5/GCLC/SOD2/HIF1A/CEBPB 7 GO:0009185 ribonucleoside diphosphate metabolic process 5/147 106/18722 0.00149562141807669 0.0381346740759156 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:0002262 myeloid cell homeostasis 6/147 157/18722 0.0015123573926429 0.0381346740759156 SLC15A4/HSPA1A/VEGFA/PKNOX1/HSPA1B/HIF1A 6 GO:2000756 regulation of peptidyl-lysine acetylation 4/147 63/18722 0.00151722708627013 0.0381346740759156 PPARGC1A/SNCA/PRKAA2/PIH1D1 4 GO:0046034 ATP metabolic process 8/147 277/18722 0.00157420639338214 0.0392370943550498 PPARGC1A/SNCA/HSPA1A/AK4/PRKAA2/HSPA1B/PKM/HIF1A 8 GO:0072503 cellular divalent inorganic cation homeostasis 11/147 486/18722 0.00160279444694246 0.0394786288342417 BDKRB2/SNCA/MT1A/SLC30A1/MT1X/CHERP/GJA1/SLC39A14/CD55/SMAD3/TRPC4 11 GO:0031349 positive regulation of defense response 8/147 278/18722 0.00161029512463306 0.0394786288342417 PLSCR1/SNCA/SLC15A4/HLA-F/HEXIM1/PARP9/GJA1/CEBPB 8 GO:0045088 regulation of innate immune response 7/147 218/18722 0.00169543818704508 0.0407676186633274 SOCS1/PLSCR1/SLC15A4/HLA-F/HEXIM1/PARP9/YTHDF2 7 GO:0038034 signal transduction in absence of ligand 4/147 65/18722 0.00170376206383013 0.0407676186633274 PPP2R1B/HSPA1A/SRPX/HSPA1B 4 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 4/147 65/18722 0.00170376206383013 0.0407676186633274 PPP2R1B/HSPA1A/SRPX/HSPA1B 4 GO:0036294 cellular response to decreased oxygen levels 6/147 161/18722 0.00171867041574244 0.0407979620117907 PPARGC1A/AK4/NDRG1/VEGFA/MYC/HIF1A 6 GO:0060759 regulation of response to cytokine stimulus 6/147 162/18722 0.00177343492802732 0.0417664871632262 SOCS1/HSPA1A/PARP9/YTHDF2/HSPA1B/HIF1A 6 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 7/147 221/18722 0.00183226986939096 0.0427790037130438 SHH/HSPA1A/PSMC4/ALAD/HSPA1B/GCLC/DAB2 7 GO:0045861 negative regulation of proteolysis 9/147 351/18722 0.00184503225643017 0.0427790037130438 SNCA/SHH/ALAD/CST2/RARRES1/VEGFA/PLAT/SPOCK1/PIH1D1 9 GO:0042060 wound healing 10/147 422/18722 0.00186504955498276 0.0429104862996419 PLSCR1/SHH/B4GALT1/VEGFA/MYOF/GJA1/TSKU/PLAT/SMAD3/HIF1A 10 GO:0046635 positive regulation of alpha-beta T cell activation 4/147 67/18722 0.0019056541073103 0.0435100109539322 SOCS1/SHH/CBFB/CD55 4 GO:2001234 negative regulation of apoptotic signaling pathway 7/147 224/18722 0.00197753129557186 0.0447692590604907 BDKRB2/HSPA1A/HSPA1B/GCLC/PIH1D1/SOD2/HIF1A 7 GO:0010039 response to iron ion 3/147 32/18722 0.00199074271315455 0.0447692590604907 SNCA/ALAD/HIF1A 3 GO:0034599 cellular response to oxidative stress 8/147 288/18722 0.00200850090191262 0.0448315387882137 PPARGC1A/SNCA/HSPA1A/PRKAA2/FOS/HSPA1B/SOD2/HIF1A 8 GO:0032103 positive regulation of response to external stimulus 10/147 427/18722 0.00203249520489949 0.0450310604285509 PLSCR1/SNCA/SLC15A4/TPBG/HLA-F/HEXIM1/VEGFA/PARP9/SMAD3/CEBPB 10 GO:1901800 positive regulation of proteasomal protein catabolic process 5/147 114/18722 0.00206103503509041 0.0453276161026133 HSPA1A/PSMC4/HSPA1B/GCLC/DAB2 5 GO:0071375 cellular response to peptide hormone stimulus 8/147 290/18722 0.00209673066031994 0.0455408370137122 SOCS1/GH2/LPIN3/IRS2/SLC39A14/GCLC/PKM/SOCS3 8 GO:0098657 import into cell 7/147 227/18722 0.00213156846209105 0.0455408370137122 SNCA/SLC15A4/SLC15A1/SLC30A1/IRS2/SLC7A2/SLC39A14 7 GO:1901653 cellular response to peptide 9/147 359/18722 0.00214904203206931 0.0455408370137122 SOCS1/GH2/LPIN3/IRS2/GJA1/SLC39A14/GCLC/PKM/SOCS3 9 GO:0045648 positive regulation of erythrocyte differentiation 3/147 33/18722 0.00217731183315307 0.0455408370137122 HSPA1A/HSPA1B/HIF1A 3 GO:0046685 response to arsenic-containing substance 3/147 33/18722 0.00217731183315307 0.0455408370137122 ALAD/ZFAND1/GCLC 3 GO:1902692 regulation of neuroblast proliferation 3/147 33/18722 0.00217731183315307 0.0455408370137122 SHH/VEGFA/HIF1A 3 GO:1903715 regulation of aerobic respiration 3/147 33/18722 0.00217731183315307 0.0455408370137122 SNCA/AK4/HIF1A 3 GO:0043200 response to amino acid 5/147 116/18722 0.00222386438459276 0.0461915164883122 SOCS1/PPARGC1A/ALAD/GCLC/CEBPB 5 GO:0045732 positive regulation of protein catabolic process 7/147 231/18722 0.00235121074891295 0.0484998024137837 HSPA1A/PSMC4/GJA1/C4BPA/HSPA1B/GCLC/DAB2 7 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/147 34/18722 0.00237438739925682 0.0486424158299804 PPARGC1A/PRKAA2/PIH1D1 3 GO:1903706 regulation of hemopoiesis 9/147 367/18722 0.00249178336288086 0.0494252595764054 SOCS1/SHH/HSPA1A/CBFB/FOS/HSPA1B/MYC/HIF1A/CEBPB 9 GO:0030218 erythrocyte differentiation 5/147 120/18722 0.00257736728565819 0.0494252595764054 HSPA1A/VEGFA/PKNOX1/HSPA1B/HIF1A 5 GO:0001569 branching involved in blood vessel morphogenesis 3/147 35/18722 0.0025821667164091 0.0494252595764054 SHH/STK4/VEGFA 3 GO:0007020 microtubule nucleation 3/147 35/18722 0.0025821667164091 0.0494252595764054 HSPA1A/HSPA1B/CCDC57 3 GO:0006012 galactose metabolic process 2/147 10/18722 0.00264394568111831 0.0494252595764054 PPARGC1A/B4GALT1 2 GO:0010968 regulation of microtubule nucleation 2/147 10/18722 0.00264394568111831 0.0494252595764054 HSPA1A/HSPA1B 2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 2/147 10/18722 0.00264394568111831 0.0494252595764054 NNMT/PARP9 2 GO:0071372 cellular response to follicle-stimulating hormone stimulus 2/147 10/18722 0.00264394568111831 0.0494252595764054 PPARGC1A/GCLC 2 GO:0072203 cell proliferation involved in metanephros development 2/147 10/18722 0.00264394568111831 0.0494252595764054 SHH/MYC 2 GO:1902023 L-arginine transport 2/147 10/18722 0.00264394568111831 0.0494252595764054 SLC7A2/SLC25A29 2 GO:1903826 arginine transmembrane transport 2/147 10/18722 0.00264394568111831 0.0494252595764054 SLC7A2/SLC25A29 2 GO:1904338 regulation of dopaminergic neuron differentiation 2/147 10/18722 0.00264394568111831 0.0494252595764054 SHH/DKK1 2 GO:2000434 regulation of protein neddylation 2/147 10/18722 0.00264394568111831 0.0494252595764054 DCUN1D1/HIF1A 2 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/147 10/18722 0.00264394568111831 0.0494252595764054 PPP2R1B/SRPX 2 GO:0045862 positive regulation of proteolysis 9/147 372/18722 0.00272716690664087 0.0505073399817496 SNCA/HSPA1A/PSMC4/CTSH/HSPA1B/SMAD3/MYC/GCLC/DAB2 9 GO:0071453 cellular response to oxygen levels 6/147 177/18722 0.00276422595594782 0.0505073399817496 PPARGC1A/AK4/NDRG1/VEGFA/MYC/HIF1A 6 GO:0098739 import across plasma membrane 6/147 177/18722 0.00276422595594782 0.0505073399817496 SLC15A4/SLC15A1/SLC30A1/IRS2/SLC7A2/SLC39A14 6 GO:0006979 response to oxidative stress 10/147 446/18722 0.00278302243854231 0.0505073399817496 PPARGC1A/SNCA/HSPA1A/ALAD/PRKAA2/FOS/HSPA1B/GCLC/SOD2/HIF1A 10 GO:0097009 energy homeostasis 3/147 36/18722 0.00280084055663901 0.0505073399817496 PPARGC1A/PRKAA2/TSKU 3 GO:0090287 regulation of cellular response to growth factor stimulus 8/147 304/18722 0.00280314892576744 0.0505073399817496 HSPA1A/HTRA3/BCL9L/PMEPA1/TOB1/SMAD3/DAB2/HIF1A 8 GO:0009266 response to temperature stimulus 6/147 178/18722 0.00284251600138762 0.0509099722164693 PPARGC1A/HSPA1A/FOS/HSPA1B/GCLC/SOD2 6 GO:0009132 nucleoside diphosphate metabolic process 5/147 124/18722 0.00296998366659185 0.0528763163498585 PPARGC1A/AK4/PRKAA2/PKM/HIF1A 5 GO:1901983 regulation of protein acetylation 4/147 77/18722 0.00316745597158996 0.054326090535804 PPARGC1A/SNCA/PRKAA2/PIH1D1 4 GO:0061138 morphogenesis of a branching epithelium 6/147 182/18722 0.00317239451451725 0.054326090535804 SHH/STK4/CTSH/VEGFA/MYC/SOCS3 6 GO:0030099 myeloid cell differentiation 9/147 381/18722 0.00319505887711574 0.054326090535804 HSPA1A/CBFB/FOS/VEGFA/PKNOX1/HSPA1B/MYC/HIF1A/CEBPB 9 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 2/147 11/18722 0.00321488399359322 0.054326090535804 CD55/C4BPA 2 GO:0010269 response to selenium ion 2/147 11/18722 0.00321488399359322 0.054326090535804 ALAD/SOD2 2 GO:0033483 gas homeostasis 2/147 11/18722 0.00321488399359322 0.054326090535804 SOD2/HIF1A 2 GO:0090084 negative regulation of inclusion body assembly 2/147 11/18722 0.00321488399359322 0.054326090535804 HSPA1A/HSPA1B 2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 2/147 11/18722 0.00321488399359322 0.054326090535804 HSPA1A/HSPA1B 2 GO:2001053 regulation of mesenchymal cell apoptotic process 2/147 11/18722 0.00321488399359322 0.054326090535804 SHH/HIF1A 2 GO:1903580 positive regulation of ATP metabolic process 3/147 38/18722 0.00327160289004342 0.0549739564276397 PPARGC1A/PRKAA2/HIF1A 3 GO:0051402 neuron apoptotic process 7/147 246/18722 0.00333403405918726 0.0557100327990452 PPARGC1A/SNCA/DNAJC5/GCLC/SOD2/HIF1A/CEBPB 7 GO:0007498 mesoderm development 5/147 129/18722 0.00351939967621036 0.0575978544935887 SHH/VEGFA/GJA1/SMAD3/DKK1 5 GO:0034101 erythrocyte homeostasis 5/147 129/18722 0.00351939967621036 0.0575978544935887 HSPA1A/VEGFA/PKNOX1/HSPA1B/HIF1A 5 GO:0010463 mesenchymal cell proliferation 3/147 39/18722 0.00352404124785247 0.0575978544935887 SHH/IRS2/MYC 3 GO:1901861 regulation of muscle tissue development 3/147 39/18722 0.00352404124785247 0.0575978544935887 PPARGC1A/SHH/SMAD3 3 GO:0071229 cellular response to acid chemical 4/147 80/18722 0.00363548681475983 0.0590964188203622 SOCS1/VEGFA/GCLC/CEBPB 4 GO:0045089 positive regulation of innate immune response 5/147 131/18722 0.00375836992934494 0.0594798199670188 PLSCR1/SLC15A4/HLA-F/HEXIM1/PARP9 5 GO:0071276 cellular response to cadmium ion 3/147 40/18722 0.00378807407130587 0.0594798199670188 MT1A/MT1X/FOS 3 GO:0006096 glycolytic process 4/147 81/18722 0.00380137271922813 0.0594798199670188 PPARGC1A/PRKAA2/PKM/HIF1A 4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 4/147 81/18722 0.00380137271922813 0.0594798199670188 HSPA1A/HTRA3/BCL9L/PMEPA1 4 GO:0043129 surfactant homeostasis 2/147 12/18722 0.0038380492322416 0.0594798199670188 CTSH/VEGFA 2 GO:0045117 azole transmembrane transport 2/147 12/18722 0.0038380492322416 0.0594798199670188 SLC15A4/SLC25A29 2 GO:0045916 negative regulation of complement activation 2/147 12/18722 0.0038380492322416 0.0594798199670188 CD55/C4BPA 2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/147 12/18722 0.0038380492322416 0.0594798199670188 PMEPA1/DKK1 2 GO:0097152 mesenchymal cell apoptotic process 2/147 12/18722 0.0038380492322416 0.0594798199670188 SHH/HIF1A 2 GO:0001892 embryonic placenta development 4/147 82/18722 0.00397231735211569 0.0607750426448492 STK4/HIF1A/CEBPB/SOCS3 4 GO:0006757 ATP generation from ADP 4/147 82/18722 0.00397231735211569 0.0607750426448492 PPARGC1A/PRKAA2/PKM/HIF1A 4 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 5/147 133/18722 0.00400876094498331 0.0607750426448492 HSPA1A/PSMC4/HSPA1B/GCLC/DAB2 5 GO:1903362 regulation of cellular protein catabolic process 7/147 255/18722 0.00405831334536993 0.0607750426448492 SHH/HSPA1A/PSMC4/ALAD/HSPA1B/GCLC/DAB2 7 GO:0010907 positive regulation of glucose metabolic process 3/147 41/18722 0.00406386109293542 0.0607750426448492 PPARGC1A/NNMT/IRS2 3 GO:0071634 regulation of transforming growth factor beta production 3/147 41/18722 0.00406386109293542 0.0607750426448492 TSKU/SMAD3/HIF1A 3 GO:1900371 regulation of purine nucleotide biosynthetic process 3/147 41/18722 0.00406386109293542 0.0607750426448492 PPARGC1A/SNCA/AK4 3 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 5/147 134/18722 0.00413833210623588 0.0614249575799866 SHH/HSPA1A/HSPA1B/GCLC/DAB2 5 GO:0046785 microtubule polymerization 4/147 83/18722 0.00414839232068114 0.0614249575799866 SNCA/HSPA1A/HSPA1B/CCDC57 4 GO:0005996 monosaccharide metabolic process 7/147 257/18722 0.00423432579472295 0.0619275253535385 PPARGC1A/B4GALT1/NNMT/IRS2/SLC39A14/GCLC/IGFBP4 7 GO:0042593 glucose homeostasis 7/147 258/18722 0.004324472692427 0.0619275253535385 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:0030808 regulation of nucleotide biosynthetic process 3/147 42/18722 0.00435155615238541 0.0619275253535385 PPARGC1A/SNCA/AK4 3 GO:0046688 response to copper ion 3/147 42/18722 0.00435155615238541 0.0619275253535385 SNCA/MT1A/MT1X 3 GO:0045727 positive regulation of translation 5/147 136/18722 0.0044064109296616 0.0619275253535385 PPP1R15A/PCIF1/TOB1/YTHDF2/PKM 5 GO:0033500 carbohydrate homeostasis 7/147 259/18722 0.00441606614764714 0.0619275253535385 PPARGC1A/PRKAA2/IRS2/SLC39A14/GCLC/PIH1D1/HIF1A 7 GO:0007183 SMAD protein complex assembly 2/147 13/18722 0.00451259736822182 0.0619275253535385 PMEPA1/SMAD3 2 GO:0007567 parturition 2/147 13/18722 0.00451259736822182 0.0619275253535385 RXFP1/MAFF 2 GO:0015801 aromatic amino acid transport 2/147 13/18722 0.00451259736822182 0.0619275253535385 SLC15A4/SLC25A29 2 GO:0015809 arginine transport 2/147 13/18722 0.00451259736822182 0.0619275253535385 SLC7A2/SLC25A29 2 GO:0032352 positive regulation of hormone metabolic process 2/147 13/18722 0.00451259736822182 0.0619275253535385 PPARGC1A/HIF1A 2 GO:0042541 hemoglobin biosynthetic process 2/147 13/18722 0.00451259736822182 0.0619275253535385 SLC25A37/HIF1A 2 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 2/147 13/18722 0.00451259736822182 0.0619275253535385 VEGFA/HIF1A 2 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 4/147 85/18722 0.00451621642273927 0.0619275253535385 SOCS1/GH2/PARP9/SOCS3 4 GO:0055072 iron ion homeostasis 4/147 85/18722 0.00451621642273927 0.0619275253535385 SLC25A37/SLC39A14/MYC/HIF1A 4 GO:0030879 mammary gland development 5/147 137/18722 0.00454499245236801 0.0619275253535385 VEGFA/IRS2/RXFP1/HIF1A/CEBPB 5 GO:0001763 morphogenesis of a branching structure 6/147 196/18722 0.00455501690998945 0.0619275253535385 SHH/STK4/CTSH/VEGFA/MYC/SOCS3 6 GO:0022408 negative regulation of cell-cell adhesion 6/147 196/18722 0.00455501690998945 0.0619275253535385 SOCS1/SHH/CBFB/VEGFA/YTHDF2/CEBPB 6 GO:0045981 positive regulation of nucleotide metabolic process 3/147 43/18722 0.00465130729815969 0.0621074112892662 PPARGC1A/PRKAA2/HIF1A 3 GO:0046636 negative regulation of alpha-beta T cell activation 3/147 43/18722 0.00465130729815969 0.0621074112892662 SOCS1/SHH/CBFB 3 GO:0071604 transforming growth factor beta production 3/147 43/18722 0.00465130729815969 0.0621074112892662 TSKU/SMAD3/HIF1A 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/147 43/18722 0.00465130729815969 0.0621074112892662 PPARGC1A/PRKAA2/HIF1A 3 GO:0009636 response to toxic substance 7/147 262/18722 0.00469967219684025 0.0624743090699963 MT1A/SLC30A1/ALAD/MT1X/HBG1/FOS/SOD2 7 GO:0032868 response to insulin 7/147 264/18722 0.00489624445479006 0.0641949416761733 SOCS1/LPIN3/IRS2/SLC39A14/GCLC/PKM/SOCS3 7 GO:0062012 regulation of small molecule metabolic process 8/147 334/18722 0.00493655066062729 0.0641949416761733 PPARGC1A/SNCA/AK4/NNMT/PRKAA2/IRS2/IGFBP4/HIF1A 8 GO:0030521 androgen receptor signaling pathway 3/147 44/18722 0.00496325688800536 0.0641949416761733 PMEPA1/PIAS2/DAB2 3 GO:0032007 negative regulation of TOR signaling 3/147 44/18722 0.00496325688800536 0.0641949416761733 DEPTOR/PRKAA2/HIF1A 3 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 3/147 44/18722 0.00496325688800536 0.0641949416761733 SLC15A4/HSPA1A/HSPA1B 3 GO:0015748 organophosphate ester transport 5/147 140/18722 0.00497934686354805 0.0641949416761733 PLSCR1/ATP11A/PRELID3B/SLC35B2/GJA1 5 GO:0030177 positive regulation of Wnt signaling pathway 5/147 140/18722 0.00497934686354805 0.0641949416761733 SHH/SMAD3/DLX5/DAB2/DKK1 5 GO:0071902 positive regulation of protein serine/threonine kinase activity 6/147 200/18722 0.00502101779862713 0.0644543529428916 SNCA/STK4/VEGFA/MAP3K4/PIH1D1/DKK1 6 GO:0007260 tyrosine phosphorylation of STAT protein 4/147 88/18722 0.00510818202474332 0.0652930445983217 SOCS1/GH2/PARP9/SOCS3 4 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/147 14/18722 0.00523769425008072 0.065622560948781 SOCS1/CBFB 2 GO:0048875 chemical homeostasis within a tissue 2/147 14/18722 0.00523769425008072 0.065622560948781 CTSH/VEGFA 2 GO:0051589 negative regulation of neurotransmitter transport 2/147 14/18722 0.00523769425008072 0.065622560948781 SNCA/SLC30A1 2 GO:0016051 carbohydrate biosynthetic process 6/147 202/18722 0.00526673148745836 0.065622560948781 PPARGC1A/SNCA/B4GALT1/NNMT/IRS2/SLC39A14 6 GO:0006110 regulation of glycolytic process 3/147 45/18722 0.00528754168794926 0.065622560948781 PPARGC1A/PRKAA2/HIF1A 3 GO:0048546 digestive tract morphogenesis 3/147 45/18722 0.00528754168794926 0.065622560948781 SHH/SMAD3/HIF1A 3 GO:1901985 positive regulation of protein acetylation 3/147 45/18722 0.00528754168794926 0.065622560948781 PPARGC1A/PRKAA2/PIH1D1 3 GO:0043434 response to peptide hormone 9/147 414/18722 0.005475666505138 0.0668529140063398 SOCS1/GH2/LPIN3/IRS2/GJA1/SLC39A14/GCLC/PKM/SOCS3 9 GO:1901888 regulation of cell junction assembly 6/147 204/18722 0.00552115733269281 0.0668529140063398 SNCA/SLITRK4/TPBG/VEGFA/GJA1/SMAD3 6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 4/147 90/18722 0.00553044099910641 0.0668529140063398 HSPA1A/HSPA1B/GCLC/DAB2 4 GO:0033135 regulation of peptidyl-serine phosphorylation 5/147 144/18722 0.00560327314859955 0.0668529140063398 BDKRB2/SNCA/STK4/VEGFA/DKK1 5 GO:0001657 ureteric bud development 4/147 91/18722 0.00575005527683698 0.0668529140063398 SHH/VEGFA/SMAD3/MYC 4 GO:0032496 response to lipopolysaccharide 8/147 343/18722 0.00577240362642561 0.0668529140063398 PPARGC1A/SNCA/ALAD/FOS/GJA1/CD55/SOD2/CEBPB 8 GO:0046942 carboxylic acid transport 7/147 273/18722 0.00585849717280978 0.0668529140063398 BDKRB2/SNCA/SLC15A4/GJA1/SLC7A2/SLC25A29/TRPC4 7 GO:0050679 positive regulation of epithelial cell proliferation 6/147 207/18722 0.00591951944181451 0.0668529140063398 SHH/B4GALT1/VEGFA/MYC/DLX5/HIF1A 6 GO:0010675 regulation of cellular carbohydrate metabolic process 5/147 146/18722 0.00593508336958194 0.0668529140063398 PPARGC1A/SNCA/NNMT/IRS2/IGFBP4 5 GO:0042311 vasodilation 3/147 47/18722 0.00597363660855028 0.0668529140063398 BDKRB2/GJA1/SOD2 3 GO:0045581 negative regulation of T cell differentiation 3/147 47/18722 0.00597363660855028 0.0668529140063398 SOCS1/SHH/CBFB 3 GO:0045646 regulation of erythrocyte differentiation 3/147 47/18722 0.00597363660855028 0.0668529140063398 HSPA1A/HSPA1B/HIF1A 3 GO:0048525 negative regulation of viral process 4/147 92/18722 0.00597541331754632 0.0668529140063398 MX1/PLSCR1/HEXIM1/IFIT1 4 GO:0072163 mesonephric epithelium development 4/147 92/18722 0.00597541331754632 0.0668529140063398 SHH/VEGFA/SMAD3/MYC 4 GO:0072164 mesonephric tubule development 4/147 92/18722 0.00597541331754632 0.0668529140063398 SHH/VEGFA/SMAD3/MYC 4 GO:0002070 epithelial cell maturation 2/147 15/18722 0.00601251550240903 0.0668529140063398 TFCP2L1/HIF1A 2 GO:0010273 detoxification of copper ion 2/147 15/18722 0.00601251550240903 0.0668529140063398 MT1A/MT1X 2 GO:0015671 oxygen transport 2/147 15/18722 0.00601251550240903 0.0668529140063398 HBG1/MYC 2 GO:0032354 response to follicle-stimulating hormone 2/147 15/18722 0.00601251550240903 0.0668529140063398 PPARGC1A/GCLC 2 GO:0046321 positive regulation of fatty acid oxidation 2/147 15/18722 0.00601251550240903 0.0668529140063398 PPARGC1A/IRS2 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/147 15/18722 0.00601251550240903 0.0668529140063398 PIAS2/DAB2 2 GO:0071871 response to epinephrine 2/147 15/18722 0.00601251550240903 0.0668529140063398 PPARGC1A/SNCA 2 GO:0072075 metanephric mesenchyme development 2/147 15/18722 0.00601251550240903 0.0668529140063398 SHH/MYC 2 GO:0140374 antiviral innate immune response 2/147 15/18722 0.00601251550240903 0.0668529140063398 MX1/IFIT1 2 GO:1905288 vascular associated smooth muscle cell apoptotic process 2/147 15/18722 0.00601251550240903 0.0668529140063398 STK4/SOD2 2 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 2/147 15/18722 0.00601251550240903 0.0668529140063398 STK4/SOD2 2 GO:1990169 stress response to copper ion 2/147 15/18722 0.00601251550240903 0.0668529140063398 MT1A/MT1X 2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 2/147 15/18722 0.00601251550240903 0.0668529140063398 DAB2/DKK1 2 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/147 209/18722 0.00619650147470815 0.0686434663364892 SNCA/CTSH/VEGFA/SMAD3/MYC/PIH1D1 6 GO:0035148 tube formation 5/147 148/18722 0.00628050798431426 0.0689396245324732 ATOH8/SHH/STK4/VEGFA/HIF1A 5 GO:0090311 regulation of protein deacetylation 3/147 48/18722 0.00633569317543826 0.0689396245324732 NNMT/PRKAA2/VEGFA 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/147 48/18722 0.00633569317543826 0.0689396245324732 PPP2R1B/STK4/SRPX 3 GO:0045637 regulation of myeloid cell differentiation 6/147 210/18722 0.00633848102521903 0.0689396245324732 HSPA1A/FOS/HSPA1B/MYC/HIF1A/CEBPB 6 GO:0050866 negative regulation of cell activation 6/147 210/18722 0.00633848102521903 0.0689396245324732 SOCS1/SHH/HLA-F/CBFB/GCLC/CEBPB 6 GO:0030100 regulation of endocytosis 6/147 211/18722 0.00648281570271534 0.0700247022553335 SNCA/ATAD1/VEGFA/PACSIN2/DAB2/DKK1 6 GO:0009409 response to cold 3/147 49/18722 0.00671057803377751 0.0700247022553335 PPARGC1A/FOS/SOD2 3 GO:0010823 negative regulation of mitochondrion organization 3/147 49/18722 0.00671057803377751 0.0700247022553335 PPARGC1A/HSPA1A/GCLC 3 GO:0048754 branching morphogenesis of an epithelial tube 5/147 151/18722 0.00682479336336711 0.0700247022553335 SHH/STK4/CTSH/VEGFA/MYC 5 GO:0002713 negative regulation of B cell mediated immunity 2/147 16/18722 0.00683624642546218 0.0700247022553335 CD55/C4BPA 2 GO:0002890 negative regulation of immunoglobulin mediated immune response 2/147 16/18722 0.00683624642546218 0.0700247022553335 CD55/C4BPA 2 GO:0002921 negative regulation of humoral immune response 2/147 16/18722 0.00683624642546218 0.0700247022553335 CD55/C4BPA 2 GO:0006828 manganese ion transport 2/147 16/18722 0.00683624642546218 0.0700247022553335 SLC39A14/TRPC4 2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 2/147 16/18722 0.00683624642546218 0.0700247022553335 SHH/HEXIM1 2 GO:0034393 positive regulation of smooth muscle cell apoptotic process 2/147 16/18722 0.00683624642546218 0.0700247022553335 STK4/SOD2 2 GO:0035067 negative regulation of histone acetylation 2/147 16/18722 0.00683624642546218 0.0700247022553335 SNCA/PIH1D1 2 GO:0045722 positive regulation of gluconeogenesis 2/147 16/18722 0.00683624642546218 0.0700247022553335 PPARGC1A/NNMT 2 GO:0060330 regulation of response to interferon-gamma 2/147 16/18722 0.00683624642546218 0.0700247022553335 SOCS1/PARP9 2 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/147 16/18722 0.00683624642546218 0.0700247022553335 SOCS1/PARP9 2 GO:1901163 regulation of trophoblast cell migration 2/147 16/18722 0.00683624642546218 0.0700247022553335 VEGFA/GJA1 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/147 16/18722 0.00683624642546218 0.0700247022553335 DAB2/DKK1 2 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/147 16/18722 0.00683624642546218 0.0700247022553335 SMAD3/PIH1D1 2 GO:0001823 mesonephros development 4/147 96/18722 0.00693556064643075 0.0705627871195615 SHH/VEGFA/SMAD3/MYC 4 GO:0015711 organic anion transport 8/147 354/18722 0.00693596102077936 0.0705627871195615 BDKRB2/SNCA/SLC15A4/SLC35B2/GJA1/SLC7A2/SLC25A29/TRPC4 8 GO:0031056 regulation of histone modification 5/147 152/18722 0.00701333553884642 0.0708678601239515 PPARGC1A/SNCA/NNMT/VEGFA/PIH1D1 5 GO:0098754 detoxification 5/147 152/18722 0.00701333553884642 0.0708678601239515 MT1A/SLC30A1/MT1X/HBG1/SOD2 5 GO:0046638 positive regulation of alpha-beta T cell differentiation 3/147 50/18722 0.0070984014304764 0.0714859214766158 SOCS1/SHH/CBFB 3 GO:0052548 regulation of endopeptidase activity 9/147 432/18722 0.00716425168072045 0.0716901694184715 SNCA/CST2/RARRES1/CTSH/VEGFA/SPOCK1/SMAD3/MYC/PIH1D1 9 GO:0043255 regulation of carbohydrate biosynthetic process 4/147 97/18722 0.00719058870797106 0.0716901694184715 PPARGC1A/SNCA/NNMT/IRS2 4 GO:0120162 positive regulation of cold-induced thermogenesis 4/147 97/18722 0.00719058870797106 0.0716901694184715 PPARGC1A/VEGFA/GJA1/CEBPB 4 GO:0002683 negative regulation of immune system process 9/147 434/18722 0.00737406898023891 0.0732752170096166 SOCS1/SHH/HLA-F/CBFB/CD55/C4BPA/YTHDF2/MYC/CEBPB 9 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 4/147 98/18722 0.00745173540363784 0.0736577410547977 BDKRB2/HSPA1A/SOD2/HIF1A 4 GO:0071900 regulation of protein serine/threonine kinase activity 8/147 359/18722 0.00752005901111986 0.0736577410547977 SNCA/CCNH/STK4/HEXIM1/VEGFA/MAP3K4/PIH1D1/DKK1 8 GO:0048732 gland development 9/147 436/18722 0.00758856652509345 0.0736577410547977 SHH/AK4/TFCP2L1/VEGFA/IRS2/RXFP1/SMAD3/HIF1A/CEBPB 9 GO:1903364 positive regulation of cellular protein catabolic process 5/147 155/18722 0.00760079066757119 0.0736577410547977 HSPA1A/PSMC4/HSPA1B/GCLC/DAB2 5 GO:0020027 hemoglobin metabolic process 2/147 17/18722 0.00770808189573778 0.0736577410547977 SLC25A37/HIF1A 2 GO:0021924 cell proliferation in external granule layer 2/147 17/18722 0.00770808189573778 0.0736577410547977 SHH/PSMG1 2 GO:0021930 cerebellar granule cell precursor proliferation 2/147 17/18722 0.00770808189573778 0.0736577410547977 SHH/PSMG1 2 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/147 17/18722 0.00770808189573778 0.0736577410547977 SOCS1/SOCS3 2 GO:0060644 mammary gland epithelial cell differentiation 2/147 17/18722 0.00770808189573778 0.0736577410547977 HIF1A/CEBPB 2 GO:0061450 trophoblast cell migration 2/147 17/18722 0.00770808189573778 0.0736577410547977 VEGFA/GJA1 2 GO:0071371 cellular response to gonadotropin stimulus 2/147 17/18722 0.00770808189573778 0.0736577410547977 PPARGC1A/GCLC 2 GO:0090083 regulation of inclusion body assembly 2/147 17/18722 0.00770808189573778 0.0736577410547977 HSPA1A/HSPA1B 2 GO:0044706 multi-multicellular organism process 6/147 220/18722 0.00789143567497995 0.074900695752754 B4GALT1/FOS/VEGFA/RXFP1/GJA1/MAFF 6 GO:0010718 positive regulation of epithelial to mesenchymal transition 3/147 52/18722 0.00791327979199942 0.074900695752754 BCL9L/SMAD3/DAB2 3 GO:0048260 positive regulation of receptor-mediated endocytosis 3/147 52/18722 0.00791327979199942 0.074900695752754 ATAD1/VEGFA/DAB2 3 GO:0045807 positive regulation of endocytosis 4/147 100/18722 0.00799262237840916 0.0751358249495132 SNCA/ATAD1/VEGFA/DAB2 4 GO:0051250 negative regulation of lymphocyte activation 5/147 157/18722 0.00801096203917175 0.0751358249495132 SOCS1/SHH/HLA-F/CBFB/CEBPB 5 GO:0002237 response to molecule of bacterial origin 8/147 363/18722 0.00801348316913898 0.0751358249495132 PPARGC1A/SNCA/ALAD/FOS/GJA1/CD55/SOD2/CEBPB 8 GO:0032259 methylation 8/147 364/18722 0.00814056134934566 0.0760888093621652 PCIF1/NNMT/FOS/MTAP/MOV10L1/RBM15B/MYC/PIH1D1 8 GO:0002707 negative regulation of lymphocyte mediated immunity 3/147 53/18722 0.00834053048493908 0.0777150363877034 HLA-F/CD55/C4BPA 3 GO:0009615 response to virus 8/147 367/18722 0.00853090359292013 0.0777229932713737 MX1/PLSCR1/IRF9/IFI44L/IFIT1/PARP9/SMAD3/HIF1A 8 GO:1902106 negative regulation of leukocyte differentiation 4/147 102/18722 0.00855868851457523 0.0777229932713737 SOCS1/SHH/CBFB/MYC 4 GO:0002076 osteoblast development 2/147 18/18722 0.00862722626750119 0.0777229932713737 SHH/SMAD3 2 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 2/147 18/18722 0.00862722626750119 0.0777229932713737 CD55/C4BPA 2 GO:0021534 cell proliferation in hindbrain 2/147 18/18722 0.00862722626750119 0.0777229932713737 SHH/PSMG1 2 GO:0032785 negative regulation of DNA-templated transcription, elongation 2/147 18/18722 0.00862722626750119 0.0777229932713737 SHH/HEXIM1 2 GO:0043217 myelin maintenance 2/147 18/18722 0.00862722626750119 0.0777229932713737 NDRG1/EPB41L3 2 GO:0045116 protein neddylation 2/147 18/18722 0.00862722626750119 0.0777229932713737 DCUN1D1/HIF1A 2 GO:0060749 mammary gland alveolus development 2/147 18/18722 0.00862722626750119 0.0777229932713737 VEGFA/HIF1A 2 GO:0061377 mammary gland lobule development 2/147 18/18722 0.00862722626750119 0.0777229932713737 VEGFA/HIF1A 2 GO:1901673 regulation of mitotic spindle assembly 2/147 18/18722 0.00862722626750119 0.0777229932713737 HSPA1A/HSPA1B 2 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3/147 54/18722 0.008781111348881 0.0784009075955315 HLA-F/CD55/C4BPA 3 GO:0035065 regulation of histone acetylation 3/147 54/18722 0.008781111348881 0.0784009075955315 PPARGC1A/SNCA/PIH1D1 3 GO:2000179 positive regulation of neural precursor cell proliferation 3/147 54/18722 0.008781111348881 0.0784009075955315 SHH/VEGFA/HIF1A 3 GO:0045639 positive regulation of myeloid cell differentiation 4/147 103/18722 0.00885130596610202 0.0787924290018189 HSPA1A/FOS/HSPA1B/HIF1A 4 GO:0034250 positive regulation of cellular amide metabolic process 5/147 162/18722 0.00910323771745913 0.0804964937673596 PPP1R15A/PCIF1/TOB1/YTHDF2/PKM 5 GO:0032006 regulation of TOR signaling 4/147 104/18722 0.00915038712166575 0.0804964937673596 DEPTOR/PRKAA2/PIH1D1/HIF1A 4 GO:0046634 regulation of alpha-beta T cell activation 4/147 104/18722 0.00915038712166575 0.0804964937673596 SOCS1/SHH/CBFB/CD55 4 GO:1901890 positive regulation of cell junction assembly 4/147 104/18722 0.00915038712166575 0.0804964937673596 SLITRK4/TPBG/VEGFA/SMAD3 4 GO:0031113 regulation of microtubule polymerization 3/147 55/18722 0.00923510839429564 0.0807666935887083 SNCA/HSPA1A/HSPA1B 3 GO:0045620 negative regulation of lymphocyte differentiation 3/147 55/18722 0.00923510839429564 0.0807666935887083 SOCS1/SHH/CBFB 3 GO:0000041 transition metal ion transport 4/147 105/18722 0.00945598647898961 0.0817478470619687 SLC25A37/SLC30A1/SLC39A14/TRPC4 4 GO:0001649 osteoblast differentiation 6/147 229/18722 0.00950852352350882 0.0817478470619687 SHH/CBFB/TOB1/SMAD3/DLX5/CEBPB 6 GO:0045444 fat cell differentiation 6/147 229/18722 0.00950852352350882 0.0817478470619687 SOCS1/PPARGC1A/TRIO/STK4/SMAD3/CEBPB 6 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 5/147 164/18722 0.00956758519775378 0.0817478470619687 SHH/HSPA1A/HSPA1B/GCLC/DAB2 5 GO:0038092 nodal signaling pathway 2/147 19/18722 0.00959289327525049 0.0817478470619687 SHH/SMAD3 2 GO:0045821 positive regulation of glycolytic process 2/147 19/18722 0.00959289327525049 0.0817478470619687 PRKAA2/HIF1A 2 GO:0072074 kidney mesenchyme development 2/147 19/18722 0.00959289327525049 0.0817478470619687 SHH/MYC 2 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 2/147 19/18722 0.00959289327525049 0.0817478470619687 SOCS1/CBFB 2 GO:0001658 branching involved in ureteric bud morphogenesis 3/147 56/18722 0.0097026030448007 0.0817478470619687 SHH/VEGFA/MYC 3 GO:0002090 regulation of receptor internalization 3/147 56/18722 0.0097026030448007 0.0817478470619687 ATAD1/VEGFA/DKK1 3 GO:0043470 regulation of carbohydrate catabolic process 3/147 56/18722 0.0097026030448007 0.0817478470619687 PPARGC1A/PRKAA2/HIF1A 3 GO:0045071 negative regulation of viral genome replication 3/147 56/18722 0.0097026030448007 0.0817478470619687 MX1/PLSCR1/IFIT1 3 GO:0048008 platelet-derived growth factor receptor signaling pathway 3/147 56/18722 0.0097026030448007 0.0817478470619687 SNCA/VEGFA/PLAT 3 GO:0006090 pyruvate metabolic process 4/147 106/18722 0.00976815765784894 0.0818391023939108 PPARGC1A/PRKAA2/PKM/HIF1A 4 GO:1903707 negative regulation of hemopoiesis 4/147 106/18722 0.00976815765784894 0.0818391023939108 SOCS1/SHH/CBFB/MYC 4 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 4/147 107/18722 0.0100869533945934 0.0841746182358226 HSPA1A/HSPA1B/GCLC/DAB2 4 GO:0007162 negative regulation of cell adhesion 7/147 303/18722 0.0101032055990172 0.0841746182358226 SOCS1/SHH/CBFB/VEGFA/SPOCK1/YTHDF2/CEBPB 7 GO:0051346 negative regulation of hydrolase activity 8/147 379/18722 0.0102341285960419 0.0850285517521148 SNCA/PPP1R15A/CST2/RARRES1/VEGFA/SPOCK1/SLC39A14/PIH1D1 8 GO:0006958 complement activation, classical pathway 4/147 108/18722 0.0104124255370232 0.0862702625519017 CFI/IGKC/CD55/C4BPA 4 GO:0002833 positive regulation of response to biotic stimulus 5/147 168/18722 0.0105447466707777 0.0863449258944906 PLSCR1/SLC15A4/HLA-F/HEXIM1/PARP9 5 GO:0014047 glutamate secretion 2/147 20/18722 0.0106043059371123 0.0863449258944906 SNCA/GJA1 2 GO:0015669 gas transport 2/147 20/18722 0.0106043059371123 0.0863449258944906 HBG1/MYC 2 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/147 20/18722 0.0106043059371123 0.0863449258944906 SOD2/HIF1A 2 GO:2000757 negative regulation of peptidyl-lysine acetylation 2/147 20/18722 0.0106043059371123 0.0863449258944906 SNCA/PIH1D1 2 GO:0007405 neuroblast proliferation 3/147 58/18722 0.010678388424442 0.0863449258944906 SHH/VEGFA/HIF1A 3 GO:0034340 response to type I interferon 3/147 58/18722 0.010678388424442 0.0863449258944906 MX1/IFIT1/YTHDF2 3 GO:0042743 hydrogen peroxide metabolic process 3/147 58/18722 0.010678388424442 0.0863449258944906 SNCA/HBG1/SOD2 3 GO:0052547 regulation of peptidase activity 9/147 461/18722 0.0106918489800091 0.0863449258944906 SNCA/CST2/RARRES1/CTSH/VEGFA/SPOCK1/SMAD3/MYC/PIH1D1 9 GO:2000116 regulation of cysteine-type endopeptidase activity 6/147 235/18722 0.0107101195275346 0.0863449258944906 SNCA/CTSH/VEGFA/SMAD3/MYC/PIH1D1 6 GO:0048259 regulation of receptor-mediated endocytosis 4/147 110/18722 0.0110836019590692 0.0891157351063871 ATAD1/VEGFA/DAB2/DKK1 4 GO:0019318 hexose metabolic process 6/147 237/18722 0.0111335667525204 0.0892260748623885 PPARGC1A/B4GALT1/NNMT/IRS2/SLC39A14/IGFBP4 6 GO:0002820 negative regulation of adaptive immune response 3/147 59/18722 0.0111868198172503 0.0892260748623885 HLA-F/CD55/C4BPA 3 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 3/147 59/18722 0.0111868198172503 0.0892260748623885 SOCS1/SH3BP5/SOCS3 3 GO:0048469 cell maturation 5/147 171/18722 0.011321024553305 0.0900563415929132 TFCP2L1/CBFB/VEGFA/YTHDF2/HIF1A 5 GO:0030449 regulation of complement activation 2/147 21/18722 0.01166069645916 0.0909654795893084 CD55/C4BPA 2 GO:0046885 regulation of hormone biosynthetic process 2/147 21/18722 0.01166069645916 0.0909654795893084 PPARGC1A/HIF1A 2 GO:0051152 positive regulation of smooth muscle cell differentiation 2/147 21/18722 0.01166069645916 0.0909654795893084 SHH/SOD2 2 GO:0072111 cell proliferation involved in kidney development 2/147 21/18722 0.01166069645916 0.0909654795893084 SHH/MYC 2 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/147 21/18722 0.01166069645916 0.0909654795893084 HSPA1A/GCLC 2 GO:1901863 positive regulation of muscle tissue development 2/147 21/18722 0.01166069645916 0.0909654795893084 PPARGC1A/SHH 2 GO:0002712 regulation of B cell mediated immunity 3/147 60/18722 0.0117090303048759 0.0909654795893084 SLC15A4/CD55/C4BPA 3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 3/147 60/18722 0.0117090303048759 0.0909654795893084 SLC15A4/HSPA1A/HSPA1B 3 GO:0002889 regulation of immunoglobulin mediated immune response 3/147 60/18722 0.0117090303048759 0.0909654795893084 SLC15A4/CD55/C4BPA 3 GO:0051051 negative regulation of transport 9/147 470/18722 0.0120157425094818 0.0931064400151818 PLSCR1/SNCA/SHH/GEM/SLC30A1/HLA-F/IRS2/GJA1/PACSIN2 9 GO:0031623 receptor internalization 4/147 113/18722 0.0121416842353364 0.093839218470003 SNCA/ATAD1/VEGFA/DKK1 4 GO:0018105 peptidyl-serine phosphorylation 7/147 315/18722 0.0123116593816758 0.0949076629138979 BDKRB2/SNCA/STK4/PRKAA2/VEGFA/TLK1/DKK1 7 GO:0043414 macromolecule methylation 7/147 316/18722 0.0125102353969159 0.0961905246071348 PCIF1/NNMT/FOS/MOV10L1/RBM15B/MYC/PIH1D1 7 GO:0010310 regulation of hydrogen peroxide metabolic process 2/147 22/18722 0.0127613061406462 0.0973789183494149 SNCA/SOD2 2 GO:0034755 iron ion transmembrane transport 2/147 22/18722 0.0127613061406462 0.0973789183494149 SLC25A37/SLC39A14 2 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 3/147 62/18722 0.012795023373895 0.0973789183494149 PMEPA1/DAB2/DKK1 3 GO:0060675 ureteric bud morphogenesis 3/147 62/18722 0.012795023373895 0.0973789183494149 SHH/VEGFA/MYC 3 GO:0008286 insulin receptor signaling pathway 4/147 116/18722 0.0132624783203354 0.100393239563152 SOCS1/IRS2/SLC39A14/SOCS3 4 GO:0001947 heart looping 3/147 63/18722 0.0133589131882763 0.100393239563152 SHH/SMAD3/HIF1A 3 GO:0002704 negative regulation of leukocyte mediated immunity 3/147 63/18722 0.0133589131882763 0.100393239563152 HLA-F/CD55/C4BPA 3 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 3/147 63/18722 0.0133589131882763 0.100393239563152 HSPA1A/PPP1R15A/CEBPB 3 GO:0072171 mesonephric tubule morphogenesis 3/147 63/18722 0.0133589131882763 0.100393239563152 SHH/VEGFA/MYC 3 GO:0006869 lipid transport 8/147 398/18722 0.01343140727379 0.100685060541117 BDKRB2/PLSCR1/SHH/ATP11A/PRELID3B/PLIN2/IRS2/TSKU 8 GO:0014902 myotube differentiation 4/147 117/18722 0.0136502225518481 0.102069539131444 SHH/PTGFRN/ATP11A/MYOF 4 GO:0002082 regulation of oxidative phosphorylation 2/147 23/18722 0.0139053852801406 0.102948038051734 SNCA/AK4 2 GO:0042026 protein refolding 2/147 23/18722 0.0139053852801406 0.102948038051734 HSPA1A/HSPA1B 2 GO:0051131 chaperone-mediated protein complex assembly 2/147 23/18722 0.0139053852801406 0.102948038051734 HSPA1A/PSMG1 2 GO:2001169 regulation of ATP biosynthetic process 2/147 23/18722 0.0139053852801406 0.102948038051734 PPARGC1A/AK4 2 GO:0060537 muscle tissue development 8/147 403/18722 0.0143825340598863 0.105730887557541 PPARGC1A/SHH/FOS/VEGFA/GJA1/MAFF/SMAD3/DKK1 8 GO:0060562 epithelial tube morphogenesis 7/147 325/18722 0.0144027878190167 0.105730887557541 SHH/STK4/CTSH/VEGFA/SMAD3/MYC/HIF1A 7 GO:0010906 regulation of glucose metabolic process 4/147 119/18722 0.0144471882191996 0.105730887557541 PPARGC1A/NNMT/IRS2/IGFBP4 4 GO:0015909 long-chain fatty acid transport 3/147 65/18722 0.014528717748629 0.105730887557541 BDKRB2/PLIN2/IRS2 3 GO:0060389 pathway-restricted SMAD protein phosphorylation 3/147 65/18722 0.014528717748629 0.105730887557541 PMEPA1/DAB2/DKK1 3 GO:1902475 L-alpha-amino acid transmembrane transport 3/147 65/18722 0.014528717748629 0.105730887557541 SLC15A4/SLC7A2/SLC25A29 3 GO:1905330 regulation of morphogenesis of an epithelium 3/147 65/18722 0.014528717748629 0.105730887557541 SHH/VEGFA/GJA1 3 GO:0010951 negative regulation of endopeptidase activity 6/147 252/18722 0.0146945228878128 0.106419656071303 SNCA/CST2/RARRES1/VEGFA/SPOCK1/PIH1D1 6 GO:0061448 connective tissue development 6/147 252/18722 0.0146945228878128 0.106419656071303 PPARGC1A/RXFP1/TSKU/SLC39A14/SMAD3/HIF1A 6 GO:0010288 response to lead ion 2/147 24/18722 0.015092193082566 0.107222682921508 PLSCR1/ALAD 2 GO:0030878 thyroid gland development 2/147 24/18722 0.015092193082566 0.107222682921508 SHH/SMAD3 2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 2/147 24/18722 0.015092193082566 0.107222682921508 IGFBP4/IGFBP6 2 GO:0060571 morphogenesis of an epithelial fold 2/147 24/18722 0.015092193082566 0.107222682921508 SHH/HIF1A 2 GO:0070841 inclusion body assembly 2/147 24/18722 0.015092193082566 0.107222682921508 HSPA1A/HSPA1B 2 GO:0071294 cellular response to zinc ion 2/147 24/18722 0.015092193082566 0.107222682921508 MT1A/MT1X 2 GO:0071577 zinc ion transmembrane transport 2/147 24/18722 0.015092193082566 0.107222682921508 SLC30A1/SLC39A14 2 GO:1901984 negative regulation of protein acetylation 2/147 24/18722 0.015092193082566 0.107222682921508 SNCA/PIH1D1 2 GO:0009117 nucleotide metabolic process 9/147 489/18722 0.0152093726229175 0.107234121154213 PPARGC1A/SNCA/AK4/NNMT/PRKAA2/SLC35B2/PARP9/PKM/HIF1A 9 GO:0009165 nucleotide biosynthetic process 6/147 254/18722 0.0152227884074878 0.107234121154213 PPARGC1A/SNCA/AK4/NNMT/SLC35B2/PARP9 6 GO:0001704 formation of primary germ layer 4/147 121/18722 0.0152730643970895 0.107234121154213 ATOH8/GJA1/SMAD3/DKK1 4 GO:0002455 humoral immune response mediated by circulating immunoglobulin 4/147 121/18722 0.0152730643970895 0.107234121154213 CFI/IGKC/CD55/C4BPA 4 GO:0042177 negative regulation of protein catabolic process 4/147 121/18722 0.0152730643970895 0.107234121154213 SNCA/SHH/ALAD/SMAD3 4 GO:0001503 ossification 8/147 408/18722 0.0153819524658844 0.107745713876956 SHH/CBFB/TOB1/SMAD3/DLX5/HIF1A/CEBPB/DKK1 8 GO:0007611 learning or memory 6/147 255/18722 0.0154918119029605 0.108143314442792 ATAD1/TPBG/FOS/HIF1A/CEBPB/DKK1 6 GO:0031109 microtubule polymerization or depolymerization 4/147 122/18722 0.0156969432939069 0.108143314442792 SNCA/HSPA1A/HSPA1B/CCDC57 4 GO:0050868 negative regulation of T cell activation 4/147 122/18722 0.0156969432939069 0.108143314442792 SOCS1/SHH/CBFB/CEBPB 4 GO:0006879 cellular iron ion homeostasis 3/147 67/18722 0.0157548285639932 0.108143314442792 SLC39A14/MYC/HIF1A 3 GO:0009880 embryonic pattern specification 3/147 67/18722 0.0157548285639932 0.108143314442792 SHH/SMAD3/HOXD8 3 GO:0061077 chaperone-mediated protein folding 3/147 67/18722 0.0157548285639932 0.108143314442792 HSPA1A/DNAJC5/HSPA1B 3 GO:0061371 determination of heart left/right asymmetry 3/147 67/18722 0.0157548285639932 0.108143314442792 SHH/SMAD3/HIF1A 3 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 3/147 67/18722 0.0157548285639932 0.108143314442792 SOCS1/CBFB/CD55 3 GO:1901293 nucleoside phosphate biosynthetic process 6/147 256/18722 0.0157641207278694 0.108143314442792 PPARGC1A/SNCA/AK4/NNMT/SLC35B2/PARP9 6 GO:0002695 negative regulation of leukocyte activation 5/147 187/18722 0.0161245806179925 0.110362976266397 SOCS1/SHH/HLA-F/CBFB/CEBPB 5 GO:0035902 response to immobilization stress 2/147 25/18722 0.0163209975671227 0.110443673582045 FOS/SOD2 2 GO:0050927 positive regulation of positive chemotaxis 2/147 25/18722 0.0163209975671227 0.110443673582045 VEGFA/SMAD3 2 GO:0060706 cell differentiation involved in embryonic placenta development 2/147 25/18722 0.0163209975671227 0.110443673582045 STK4/SOCS3 2 GO:0090169 regulation of spindle assembly 2/147 25/18722 0.0163209975671227 0.110443673582045 HSPA1A/HSPA1B 2 GO:0090312 positive regulation of protein deacetylation 2/147 25/18722 0.0163209975671227 0.110443673582045 NNMT/VEGFA 2 GO:0046637 regulation of alpha-beta T cell differentiation 3/147 68/18722 0.0163890872326141 0.110654085581826 SOCS1/SHH/CBFB 3 GO:0007368 determination of left/right symmetry 4/147 124/18722 0.0165667733213647 0.111601844604058 SHH/SMAD3/BICC1/HIF1A 4 GO:0001558 regulation of cell growth 8/147 414/18722 0.0166468348418289 0.111889175307663 HSPA1A/VEGFA/GJA1/SPOCK1/EPB41L3/HSPA1B/SMAD3/IGFBP4 8 GO:0006753 nucleoside phosphate metabolic process 9/147 497/18722 0.0167267023467616 0.112173916410682 PPARGC1A/SNCA/AK4/NNMT/PRKAA2/SLC35B2/PARP9/PKM/HIF1A 9 GO:0016032 viral process 8/147 415/18722 0.0168647484215954 0.11274051663659 MX1/PLSCR1/HSPA1A/HEXIM1/IFIT1/PARP9/CD55/HSPA1B 8 GO:0051091 positive regulation of DNA-binding transcription factor activity 6/147 260/18722 0.0168865768817092 0.11274051663659 PPARGC1A/SHH/HSPA1A/VEGFA/HSPA1B/SMAD3 6 GO:2000027 regulation of animal organ morphogenesis 4/147 125/18722 0.017012797914925 0.113242725020061 SHH/VEGFA/DAB2/DKK1 4 GO:0003143 embryonic heart tube morphogenesis 3/147 69/18722 0.0170375213169601 0.113242725020061 SHH/SMAD3/HIF1A 3 GO:0072521 purine-containing compound metabolic process 8/147 416/18722 0.0170847177700334 0.113304636031419 PPARGC1A/SNCA/AK4/PRKAA2/MTAP/SLC35B2/PKM/HIF1A 8 GO:0031929 TOR signaling 4/147 126/18722 0.0174662763233037 0.114380232063045 DEPTOR/PRKAA2/PIH1D1/HIF1A 4 GO:2001235 positive regulation of apoptotic signaling pathway 4/147 126/18722 0.0174662763233037 0.114380232063045 PPP2R1B/STK4/CTSH/SRPX 4 GO:0010466 negative regulation of peptidase activity 6/147 262/18722 0.0174679911476457 0.114380232063045 SNCA/CST2/RARRES1/VEGFA/SPOCK1/PIH1D1 6 GO:0018209 peptidyl-serine modification 7/147 338/18722 0.017486554704791 0.114380232063045 BDKRB2/SNCA/STK4/PRKAA2/VEGFA/TLK1/DKK1 7 GO:0002092 positive regulation of receptor internalization 2/147 26/18722 0.0175910754760952 0.114380232063045 ATAD1/VEGFA 2 GO:0009435 NAD biosynthetic process 2/147 26/18722 0.0175910754760952 0.114380232063045 NNMT/PARP9 2 GO:0034063 stress granule assembly 2/147 26/18722 0.0175910754760952 0.114380232063045 PRKAA2/YTHDF2 2 GO:0050926 regulation of positive chemotaxis 2/147 26/18722 0.0175910754760952 0.114380232063045 VEGFA/SMAD3 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/147 26/18722 0.0175910754760952 0.114380232063045 DAB2/DKK1 2 GO:0007568 aging 7/147 339/18722 0.017741633283788 0.115003349998125 PPARGC1A/SNCA/TFCP2L1/FOS/GCLC/SOD2/DKK1 7 GO:0003018 vascular process in circulatory system 6/147 263/18722 0.0177638073216762 0.115003349998125 BDKRB2/VEGFA/GJA1/SLC7A2/GCLC/SOD2 6 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 6/147 264/18722 0.0180630529697433 0.116688102446009 SOCS1/GH2/SH3BP5/VEGFA/PARP9/SOCS3 6 GO:0030522 intracellular receptor signaling pathway 6/147 265/18722 0.0183657455041898 0.117197548091105 SLC15A4/HSPA1A/PMEPA1/PIAS2/HSPA1B/DAB2 6 GO:0051607 defense response to virus 6/147 265/18722 0.0183657455041898 0.117197548091105 MX1/PLSCR1/IRF9/IFI44L/IFIT1/PARP9 6 GO:0140546 defense response to symbiont 6/147 265/18722 0.0183657455041898 0.117197548091105 MX1/PLSCR1/IRF9/IFI44L/IFIT1/PARP9 6 GO:0043550 regulation of lipid kinase activity 3/147 71/18722 0.0183770143947603 0.117197548091105 SOCS1/NRBF2/SOCS3 3 GO:0071230 cellular response to amino acid stimulus 3/147 71/18722 0.0183770143947603 0.117197548091105 SOCS1/GCLC/CEBPB 3 GO:0072078 nephron tubule morphogenesis 3/147 71/18722 0.0183770143947603 0.117197548091105 SHH/VEGFA/MYC 3 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 4/147 129/18722 0.0188717739143898 0.119385641290918 SNCA/CTSH/SMAD3/MYC 4 GO:0034698 response to gonadotropin 2/147 27/18722 0.0189017121845313 0.119385641290918 PPARGC1A/GCLC 2 GO:0036037 CD8-positive, alpha-beta T cell activation 2/147 27/18722 0.0189017121845313 0.119385641290918 SOCS1/CBFB 2 GO:0060333 interferon-gamma-mediated signaling pathway 2/147 27/18722 0.0189017121845313 0.119385641290918 SOCS1/PARP9 2 GO:0048608 reproductive structure development 8/147 424/18722 0.0189196903951505 0.119385641290918 SHH/STK4/VEGFA/GJA1/MAP3K4/HIF1A/CEBPB/SOCS3 8 GO:0001707 mesoderm formation 3/147 72/18722 0.0190681141839804 0.119816658664465 GJA1/SMAD3/DKK1 3 GO:0035567 non-canonical Wnt signaling pathway 3/147 72/18722 0.0190681141839804 0.119816658664465 FZD8/DAB2/DKK1 3 GO:0006006 glucose metabolic process 5/147 196/18722 0.019346772251193 0.121112988818602 PPARGC1A/NNMT/IRS2/SLC39A14/IGFBP4 5 GO:0006956 complement activation 4/147 130/18722 0.0193554024257078 0.121112988818602 CFI/IGKC/CD55/C4BPA 4 GO:1903131 mononuclear cell differentiation 8/147 426/18722 0.0193996933270495 0.121136707184144 SOCS1/SHH/CBFB/VEGFA/PKNOX1/TPD52/MYC/CEBPB 8 GO:0048568 embryonic organ development 8/147 427/18722 0.0196429380453681 0.122145587720782 SHH/STK4/VEGFA/SMAD3/DLX5/HIF1A/CEBPB/SOCS3 8 GO:0061458 reproductive system development 8/147 427/18722 0.0196429380453681 0.122145587720782 SHH/STK4/VEGFA/GJA1/MAP3K4/HIF1A/CEBPB/SOCS3 8 GO:0051145 smooth muscle cell differentiation 3/147 73/18722 0.0197734711156924 0.122448141008356 SHH/VEGFA/SOD2 3 GO:0072088 nephron epithelium morphogenesis 3/147 73/18722 0.0197734711156924 0.122448141008356 SHH/VEGFA/MYC 3 GO:0003156 regulation of animal organ formation 2/147 28/18722 0.0202522016107873 0.123621091873194 SHH/DKK1 2 GO:0006829 zinc ion transport 2/147 28/18722 0.0202522016107873 0.123621091873194 SLC30A1/SLC39A14 2 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 2/147 28/18722 0.0202522016107873 0.123621091873194 SOCS1/SOCS3 2 GO:0051503 adenine nucleotide transport 2/147 28/18722 0.0202522016107873 0.123621091873194 SLC35B2/GJA1 2 GO:0051894 positive regulation of focal adhesion assembly 2/147 28/18722 0.0202522016107873 0.123621091873194 VEGFA/SMAD3 2 GO:0060765 regulation of androgen receptor signaling pathway 2/147 28/18722 0.0202522016107873 0.123621091873194 PIAS2/DAB2 2 GO:1903672 positive regulation of sprouting angiogenesis 2/147 28/18722 0.0202522016107873 0.123621091873194 VEGFA/PKM 2 GO:0048332 mesoderm morphogenesis 3/147 74/18722 0.0204930973551821 0.124836770243074 GJA1/SMAD3/DKK1 3 GO:0048872 homeostasis of number of cells 6/147 272/18722 0.0205825389032779 0.12512677613761 SLC15A4/HSPA1A/VEGFA/PKNOX1/HSPA1B/HIF1A 6 GO:0002449 lymphocyte mediated immunity 7/147 350/18722 0.0207231318684892 0.125725937968867 CFI/IGKC/SLC15A4/HLA-F/CTSH/CD55/C4BPA 7 GO:0009855 determination of bilateral symmetry 4/147 133/18722 0.0208521058157812 0.126252324888667 SHH/SMAD3/BICC1/HIF1A 4 GO:0072522 purine-containing compound biosynthetic process 5/147 200/18722 0.0209054481348276 0.126319586608625 PPARGC1A/SNCA/AK4/MTAP/SLC35B2 5 GO:0006094 gluconeogenesis 3/147 75/18722 0.0212270018930743 0.127746403746851 PPARGC1A/NNMT/SLC39A14 3 GO:0061333 renal tubule morphogenesis 3/147 75/18722 0.0212270018930743 0.127746403746851 SHH/VEGFA/MYC 3 GO:0009799 specification of symmetry 4/147 134/18722 0.0213663757760749 0.12817972627453 SHH/SMAD3/BICC1/HIF1A 4 GO:0051480 regulation of cytosolic calcium ion concentration 7/147 353/18722 0.0215934729318218 0.12817972627453 BDKRB2/SNCA/CHERP/GJA1/CD55/SMAD3/TRPC4 7 GO:0015868 purine ribonucleotide transport 2/147 29/18722 0.0216418461279297 0.12817972627453 SLC35B2/GJA1 2 GO:0019359 nicotinamide nucleotide biosynthetic process 2/147 29/18722 0.0216418461279297 0.12817972627453 NNMT/PARP9 2 GO:0019363 pyridine nucleotide biosynthetic process 2/147 29/18722 0.0216418461279297 0.12817972627453 NNMT/PARP9 2 GO:0035066 positive regulation of histone acetylation 2/147 29/18722 0.0216418461279297 0.12817972627453 PPARGC1A/PIH1D1 2 GO:0060441 epithelial tube branching involved in lung morphogenesis 2/147 29/18722 0.0216418461279297 0.12817972627453 SHH/CTSH 2 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/147 29/18722 0.0216418461279297 0.12817972627453 SOD2/HIF1A 2 GO:0006305 DNA alkylation 3/147 76/18722 0.0219751906096451 0.12938542345167 FOS/MOV10L1/MYC 3 GO:0006306 DNA methylation 3/147 76/18722 0.0219751906096451 0.12938542345167 FOS/MOV10L1/MYC 3 GO:0072028 nephron morphogenesis 3/147 76/18722 0.0219751906096451 0.12938542345167 SHH/VEGFA/MYC 3 GO:0051701 biological process involved in interaction with host 5/147 203/18722 0.0221268518025412 0.129767477924315 PLSCR1/HSPA1A/IFIT1/CD55/HSPA1B 5 GO:0060541 respiratory system development 5/147 203/18722 0.0221268518025412 0.129767477924315 SHH/CTSH/VEGFA/RXFP1/DLX5 5 GO:0072073 kidney epithelium development 4/147 136/18722 0.022418132475266 0.131218462296518 SHH/VEGFA/SMAD3/MYC 4 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7/147 356/18722 0.0224889552074676 0.131375908252999 CFI/IGKC/SLC15A4/HLA-F/CTSH/CD55/C4BPA 7 GO:1902105 regulation of leukocyte differentiation 6/147 279/18722 0.0229747722680063 0.132441919039689 SOCS1/SHH/CBFB/FOS/MYC/CEBPB 6 GO:0008209 androgen metabolic process 2/147 30/18722 0.0230699564759874 0.132441919039689 PPARGC1A/SHH 2 GO:0015865 purine nucleotide transport 2/147 30/18722 0.0230699564759874 0.132441919039689 SLC35B2/GJA1 2 GO:0033137 negative regulation of peptidyl-serine phosphorylation 2/147 30/18722 0.0230699564759874 0.132441919039689 BDKRB2/DKK1 2 GO:0034390 smooth muscle cell apoptotic process 2/147 30/18722 0.0230699564759874 0.132441919039689 STK4/SOD2 2 GO:0034391 regulation of smooth muscle cell apoptotic process 2/147 30/18722 0.0230699564759874 0.132441919039689 STK4/SOD2 2 GO:0045948 positive regulation of translational initiation 2/147 30/18722 0.0230699564759874 0.132441919039689 PPP1R15A/YTHDF2 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/147 30/18722 0.0230699564759874 0.132441919039689 IRS2/HIF1A 2 GO:1903579 negative regulation of ATP metabolic process 2/147 30/18722 0.0230699564759874 0.132441919039689 PPARGC1A/SNCA 2 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 3/147 78/18722 0.0235144289276339 0.133203895686653 SNCA/CTSH/SMAD3 3 GO:0008306 associative learning 3/147 78/18722 0.0235144289276339 0.133203895686653 TPBG/FOS/HIF1A 3 GO:0019319 hexose biosynthetic process 3/147 78/18722 0.0235144289276339 0.133203895686653 PPARGC1A/NNMT/SLC39A14 3 GO:0032024 positive regulation of insulin secretion 3/147 78/18722 0.0235144289276339 0.133203895686653 IRS2/GJA1/HIF1A 3 GO:0035050 embryonic heart tube development 3/147 78/18722 0.0235144289276339 0.133203895686653 SHH/SMAD3/HIF1A 3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 3/147 78/18722 0.0235144289276339 0.133203895686653 SNCA/VEGFA/PIH1D1 3 GO:0061045 negative regulation of wound healing 3/147 78/18722 0.0235144289276339 0.133203895686653 GJA1/PLAT/SMAD3 3 GO:0016064 immunoglobulin mediated immune response 5/147 207/18722 0.0238263325908455 0.134715615839733 CFI/IGKC/SLC15A4/CD55/C4BPA 5 GO:0045598 regulation of fat cell differentiation 4/147 139/18722 0.0240541874385481 0.135747310620183 TRIO/STK4/SMAD3/CEBPB 4 GO:0051251 positive regulation of lymphocyte activation 7/147 362/18722 0.0243566173389046 0.136406565725018 SOCS1/IGKC/SHH/HLA-F/CBFB/IRS2/CD55 7 GO:0044262 cellular carbohydrate metabolic process 6/147 283/18722 0.0244226099958359 0.136406565725018 PPARGC1A/SNCA/B4GALT1/NNMT/IRS2/IGFBP4 6 GO:0051146 striated muscle cell differentiation 6/147 283/18722 0.0244226099958359 0.136406565725018 SHH/PTGFRN/ATP11A/VEGFA/MYOF/DKK1 6 GO:0033238 regulation of cellular amine metabolic process 2/147 31/18722 0.0245358516750449 0.136406565725018 SNCA/NNMT 2 GO:0051569 regulation of histone H3-K4 methylation 2/147 31/18722 0.0245358516750449 0.136406565725018 NNMT/PIH1D1 2 GO:0060055 angiogenesis involved in wound healing 2/147 31/18722 0.0245358516750449 0.136406565725018 B4GALT1/VEGFA 2 GO:0060390 regulation of SMAD protein signal transduction 2/147 31/18722 0.0245358516750449 0.136406565725018 TOB1/DAB2 2 GO:0090183 regulation of kidney development 2/147 31/18722 0.0245358516750449 0.136406565725018 VEGFA/MYC 2 GO:1901264 carbohydrate derivative transport 3/147 80/18722 0.02511079953072 0.138673604523643 SLC15A4/SLC35B2/GJA1 3 GO:0019724 B cell mediated immunity 5/147 210/18722 0.0251548440520631 0.138673604523643 CFI/IGKC/SLC15A4/CD55/C4BPA 5 GO:0035296 regulation of tube diameter 4/147 141/18722 0.0251841101219712 0.138673604523643 BDKRB2/GJA1/GCLC/SOD2 4 GO:0097746 blood vessel diameter maintenance 4/147 141/18722 0.0251841101219712 0.138673604523643 BDKRB2/GJA1/GCLC/SOD2 4 GO:1903038 negative regulation of leukocyte cell-cell adhesion 4/147 141/18722 0.0251841101219712 0.138673604523643 SOCS1/SHH/CBFB/CEBPB 4 GO:0006874 cellular calcium ion homeostasis 8/147 448/18722 0.0252681760165113 0.138673604523643 BDKRB2/SNCA/SLC30A1/CHERP/GJA1/CD55/SMAD3/TRPC4 8 GO:0010876 lipid localization 8/147 448/18722 0.0252681760165113 0.138673604523643 BDKRB2/PLSCR1/SHH/ATP11A/PRELID3B/PLIN2/IRS2/TSKU 8 GO:0035150 regulation of tube size 4/147 142/18722 0.0257609019922428 0.141090991099747 BDKRB2/GJA1/GCLC/SOD2 4 GO:0051149 positive regulation of muscle cell differentiation 3/147 81/18722 0.0259303928696235 0.141090991099747 SHH/ATP11A/SOD2 3 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 2/147 32/18722 0.026038858939171 0.141090991099747 SHH/HEXIM1 2 GO:0042744 hydrogen peroxide catabolic process 2/147 32/18722 0.026038858939171 0.141090991099747 SNCA/HBG1 2 GO:0072525 pyridine-containing compound biosynthetic process 2/147 32/18722 0.026038858939171 0.141090991099747 NNMT/PARP9 2 GO:0097345 mitochondrial outer membrane permeabilization 2/147 32/18722 0.026038858939171 0.141090991099747 HSPA1A/GCLC 2 GO:1900745 positive regulation of p38MAPK cascade 2/147 32/18722 0.026038858939171 0.141090991099747 VEGFA/MAP3K4 2 GO:0097193 intrinsic apoptotic signaling pathway 6/147 288/18722 0.0263168714315643 0.14198146338181 BDKRB2/HSPA1A/PPP1R15A/SOD2/HIF1A/CEBPB 6 GO:0009150 purine ribonucleotide metabolic process 7/147 368/18722 0.0263285980367463 0.14198146338181 PPARGC1A/SNCA/AK4/PRKAA2/SLC35B2/PKM/HIF1A 7 GO:0070555 response to interleukin-1 4/147 143/18722 0.0263456075482796 0.14198146338181 SNCA/GCLC/HIF1A/CEBPB 4 GO:0046364 monosaccharide biosynthetic process 3/147 82/18722 0.0267642438386428 0.143134321953664 PPARGC1A/NNMT/SLC39A14 3 GO:0007612 learning 4/147 144/18722 0.0269382456739848 0.143134321953664 ATAD1/TPBG/FOS/HIF1A 4 GO:0010821 regulation of mitochondrion organization 4/147 144/18722 0.0269382456739848 0.143134321953664 PPARGC1A/HSPA1A/GCLC/HIF1A 4 GO:0046718 viral entry into host cell 4/147 144/18722 0.0269382456739848 0.143134321953664 PLSCR1/HSPA1A/CD55/HSPA1B 4 GO:0106106 cold-induced thermogenesis 4/147 144/18722 0.0269382456739848 0.143134321953664 PPARGC1A/VEGFA/GJA1/CEBPB 4 GO:0120161 regulation of cold-induced thermogenesis 4/147 144/18722 0.0269382456739848 0.143134321953664 PPARGC1A/VEGFA/GJA1/CEBPB 4 GO:0060485 mesenchyme development 6/147 291/18722 0.0274991500410823 0.143134321953664 SHH/BCL9L/SMAD3/MYC/DAB2/HIF1A 6 GO:0061351 neural precursor cell proliferation 4/147 145/18722 0.0275388343646507 0.143134321953664 SHH/VEGFA/PSMG1/HIF1A 4 GO:0006536 glutamate metabolic process 2/147 33/18722 0.0275783135911721 0.143134321953664 ALDH5A1/GCLC 2 GO:0006891 intra-Golgi vesicle-mediated transport 2/147 33/18722 0.0275783135911721 0.143134321953664 COG1/COPB2 2 GO:0019362 pyridine nucleotide metabolic process 2/147 33/18722 0.0275783135911721 0.143134321953664 NNMT/PARP9 2 GO:0031116 positive regulation of microtubule polymerization 2/147 33/18722 0.0275783135911721 0.143134321953664 HSPA1A/HSPA1B 2 GO:0045920 negative regulation of exocytosis 2/147 33/18722 0.0275783135911721 0.143134321953664 SNCA/HLA-F 2 GO:0046320 regulation of fatty acid oxidation 2/147 33/18722 0.0275783135911721 0.143134321953664 PPARGC1A/IRS2 2 GO:0046496 nicotinamide nucleotide metabolic process 2/147 33/18722 0.0275783135911721 0.143134321953664 NNMT/PARP9 2 GO:0048333 mesodermal cell differentiation 2/147 33/18722 0.0275783135911721 0.143134321953664 GJA1/DKK1 2 GO:0099174 regulation of presynapse organization 2/147 33/18722 0.0275783135911721 0.143134321953664 SNCA/SLITRK4 2 GO:0150117 positive regulation of cell-substrate junction organization 2/147 33/18722 0.0275783135911721 0.143134321953664 VEGFA/SMAD3 2 GO:1901099 negative regulation of signal transduction in absence of ligand 2/147 33/18722 0.0275783135911721 0.143134321953664 HSPA1A/HSPA1B 2 GO:1905606 regulation of presynapse assembly 2/147 33/18722 0.0275783135911721 0.143134321953664 SNCA/SLITRK4 2 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/147 33/18722 0.0275783135911721 0.143134321953664 HSPA1A/HSPA1B 2 GO:0031397 negative regulation of protein ubiquitination 3/147 83/18722 0.0276123382705664 0.143134321953664 HSPA1A/HSPA1B/GCLC 3 GO:0001822 kidney development 6/147 293/18722 0.0283066106627948 0.146479364173736 SHH/CTSH/VEGFA/SMAD3/BICC1/MYC 6 GO:1903531 negative regulation of secretion by cell 4/147 147/18722 0.0287639310016166 0.148230885927245 SNCA/SLC30A1/HLA-F/GJA1 4 GO:0055074 calcium ion homeostasis 8/147 460/18722 0.0289463135640048 0.148230885927245 BDKRB2/SNCA/SLC30A1/CHERP/GJA1/CD55/SMAD3/TRPC4 8 GO:0018205 peptidyl-lysine modification 7/147 376/18722 0.0291242517243657 0.148230885927245 PPARGC1A/SNCA/NNMT/PRKAA2/CBX4/PIAS2/PIH1D1 7 GO:0000096 sulfur amino acid metabolic process 2/147 34/18722 0.0291535589781669 0.148230885927245 MTAP/GCLC 2 GO:0007431 salivary gland development 2/147 34/18722 0.0291535589781669 0.148230885927245 SHH/TFCP2L1 2 GO:0010661 positive regulation of muscle cell apoptotic process 2/147 34/18722 0.0291535589781669 0.148230885927245 STK4/SOD2 2 GO:0010922 positive regulation of phosphatase activity 2/147 34/18722 0.0291535589781669 0.148230885927245 PPP1R15A/SMAD3 2 GO:0051085 chaperone cofactor-dependent protein refolding 2/147 34/18722 0.0291535589781669 0.148230885927245 HSPA1A/HSPA1B 2 GO:0051973 positive regulation of telomerase activity 2/147 34/18722 0.0291535589781669 0.148230885927245 MAP3K4/MYC 2 GO:1904893 negative regulation of receptor signaling pathway via STAT 2/147 34/18722 0.0291535589781669 0.148230885927245 SOCS1/SOCS3 2 GO:0001656 metanephros development 3/147 85/18722 0.0293511877706947 0.148230885927245 SHH/CTSH/MYC 3 GO:0045069 regulation of viral genome replication 3/147 85/18722 0.0293511877706947 0.148230885927245 MX1/PLSCR1/IFIT1 3 GO:0044272 sulfur compound biosynthetic process 4/147 148/18722 0.0293884705298751 0.148230885927245 SNCA/MTAP/SLC35B2/GCLC 4 GO:0070507 regulation of microtubule cytoskeleton organization 4/147 148/18722 0.0293884705298751 0.148230885927245 SNCA/HSPA1A/PRKAA2/HSPA1B 4 GO:2001056 positive regulation of cysteine-type endopeptidase activity 4/147 148/18722 0.0293884705298751 0.148230885927245 SNCA/CTSH/SMAD3/MYC 4 GO:0050890 cognition 6/147 296/18722 0.0295469716219729 0.148779448015692 ATAD1/TPBG/FOS/HIF1A/CEBPB/DKK1 6 GO:1905039 carboxylic acid transmembrane transport 4/147 149/18722 0.0300210237951769 0.150912407010713 SLC15A4/IRS2/SLC7A2/SLC25A29 4 GO:0015908 fatty acid transport 3/147 86/18722 0.0302419015893733 0.151513446656307 BDKRB2/PLIN2/IRS2 3 GO:2000117 negative regulation of cysteine-type endopeptidase activity 3/147 86/18722 0.0302419015893733 0.151513446656307 SNCA/VEGFA/PIH1D1 3 GO:1903825 organic acid transmembrane transport 4/147 150/18722 0.0306616044086789 0.152848776821294 SLC15A4/IRS2/SLC7A2/SLC25A29 4 GO:0032350 regulation of hormone metabolic process 2/147 35/18722 0.0307639463879703 0.152848776821294 PPARGC1A/HIF1A 2 GO:0035633 maintenance of blood-brain barrier 2/147 35/18722 0.0307639463879703 0.152848776821294 VEGFA/GJA1 2 GO:0046627 negative regulation of insulin receptor signaling pathway 2/147 35/18722 0.0307639463879703 0.152848776821294 SOCS1/SOCS3 2 GO:0060236 regulation of mitotic spindle organization 2/147 35/18722 0.0307639463879703 0.152848776821294 HSPA1A/HSPA1B 2 GO:0051262 protein tetramerization 3/147 87/18722 0.0311467764823163 0.15398348505555 SNCA/STK4/SOD2 3 GO:1900182 positive regulation of protein localization to nucleus 3/147 87/18722 0.0311467764823163 0.15398348505555 SHH/PARP9/SMAD3 3 GO:2000177 regulation of neural precursor cell proliferation 3/147 87/18722 0.0311467764823163 0.15398348505555 SHH/VEGFA/HIF1A 3 GO:0044409 entry into host 4/147 151/18722 0.0313102251173948 0.154536111099221 PLSCR1/HSPA1A/CD55/HSPA1B 4 GO:0030509 BMP signaling pathway 4/147 152/18722 0.0319668978087069 0.157303689719943 HTRA3/TOB1/SMAD3/DLX5 4 GO:0031110 regulation of microtubule polymerization or depolymerization 3/147 88/18722 0.0320657856984659 0.157303689719943 SNCA/HSPA1A/HSPA1B 3 GO:0014706 striated muscle tissue development 7/147 384/18722 0.0321148291900122 0.157303689719943 SHH/FOS/VEGFA/GJA1/MAFF/SMAD3/DKK1 7 GO:0042692 muscle cell differentiation 7/147 384/18722 0.0321148291900122 0.157303689719943 SHH/PTGFRN/ATP11A/VEGFA/MYOF/SOD2/DKK1 7 GO:0072001 renal system development 6/147 302/18722 0.0321339198993263 0.157303689719943 SHH/CTSH/VEGFA/SMAD3/BICC1/MYC 6 GO:0030224 monocyte differentiation 2/147 36/18722 0.032408834966284 0.158390237555809 VEGFA/MYC 2 GO:0009259 ribonucleotide metabolic process 7/147 385/18722 0.0325026042304323 0.158589378879646 PPARGC1A/SNCA/AK4/PRKAA2/SLC35B2/PKM/HIF1A 7 GO:0051222 positive regulation of protein transport 6/147 303/18722 0.0325789848346861 0.158703165538349 SHH/IRS2/GJA1/ZFAND1/SMAD3/HIF1A 6 GO:0045860 positive regulation of protein kinase activity 7/147 386/18722 0.0328935107209574 0.159974781408754 SOCS1/SNCA/STK4/VEGFA/MAP3K4/PIH1D1/DKK1 7 GO:0016052 carbohydrate catabolic process 4/147 154/18722 0.0333044424183486 0.161448277590406 PPARGC1A/PRKAA2/PKM/HIF1A 4 GO:0030856 regulation of epithelial cell differentiation 4/147 154/18722 0.0333044424183486 0.161448277590406 ATOH8/VEGFA/MAFF/CEBPB 4 GO:0051147 regulation of muscle cell differentiation 4/147 155/18722 0.0339853338554553 0.162350297100846 SHH/ATP11A/SOD2/DKK1 4 GO:0001667 ameboidal-type cell migration 8/147 475/18722 0.0340457671945988 0.162350297100846 ATOH8/SHH/MCC/TPBG/CTSH/VEGFA/GJA1/HIF1A 8 GO:0002369 T cell cytokine production 2/147 37/18722 0.0340875916346811 0.162350297100846 HLA-F/CD55 2 GO:0002724 regulation of T cell cytokine production 2/147 37/18722 0.0340875916346811 0.162350297100846 HLA-F/CD55 2 GO:0006862 nucleotide transport 2/147 37/18722 0.0340875916346811 0.162350297100846 SLC35B2/GJA1 2 GO:0016202 regulation of striated muscle tissue development 2/147 37/18722 0.0340875916346811 0.162350297100846 SHH/SMAD3 2 GO:0031112 positive regulation of microtubule polymerization or depolymerization 2/147 37/18722 0.0340875916346811 0.162350297100846 HSPA1A/HSPA1B 2 GO:0042401 cellular biogenic amine biosynthetic process 2/147 37/18722 0.0340875916346811 0.162350297100846 SNCA/NNMT 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/147 37/18722 0.0340875916346811 0.162350297100846 IGFBP4/IGFBP6 2 GO:1900077 negative regulation of cellular response to insulin stimulus 2/147 37/18722 0.0340875916346811 0.162350297100846 SOCS1/SOCS3 2 GO:1905332 positive regulation of morphogenesis of an epithelium 2/147 37/18722 0.0340875916346811 0.162350297100846 VEGFA/GJA1 2 GO:0006631 fatty acid metabolic process 7/147 390/18722 0.034488628839898 0.163999187377003 PPARGC1A/SNCA/MCAT/LPIN3/PRKAA2/IRS2/PTGR2 7 GO:0071695 anatomical structure maturation 5/147 229/18722 0.0346728779713167 0.164359556451027 TFCP2L1/CBFB/VEGFA/YTHDF2/HIF1A 5 GO:0046631 alpha-beta T cell activation 4/147 156/18722 0.0346743163225001 0.164359556451027 SOCS1/SHH/CBFB/CD55 4 GO:0045582 positive regulation of T cell differentiation 3/147 91/18722 0.0349073167800021 0.164941207723517 SOCS1/SHH/CBFB 3 GO:0072080 nephron tubule development 3/147 91/18722 0.0349073167800021 0.164941207723517 SHH/VEGFA/MYC 3 GO:0001837 epithelial to mesenchymal transition 4/147 157/18722 0.0353713974802341 0.166084536677206 BCL9L/SMAD3/DAB2/HIF1A 4 GO:1902107 positive regulation of leukocyte differentiation 4/147 157/18722 0.0353713974802341 0.166084536677206 SOCS1/SHH/CBFB/FOS 4 GO:1903708 positive regulation of hemopoiesis 4/147 157/18722 0.0353713974802341 0.166084536677206 SOCS1/SHH/CBFB/FOS 4 GO:1990845 adaptive thermogenesis 4/147 157/18722 0.0353713974802341 0.166084536677206 PPARGC1A/VEGFA/GJA1/CEBPB 4 GO:0009309 amine biosynthetic process 2/147 38/18722 0.0357995910093833 0.166526557867909 SNCA/NNMT 2 GO:0030279 negative regulation of ossification 2/147 38/18722 0.0357995910093833 0.166526557867909 HIF1A/DKK1 2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2/147 38/18722 0.0357995910093833 0.166526557867909 PIAS2/DAB2 2 GO:0035886 vascular associated smooth muscle cell differentiation 2/147 38/18722 0.0357995910093833 0.166526557867909 VEGFA/SOD2 2 GO:0072524 pyridine-containing compound metabolic process 2/147 38/18722 0.0357995910093833 0.166526557867909 NNMT/PARP9 2 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 2/147 38/18722 0.0357995910093833 0.166526557867909 HSPA1A/GCLC 2 GO:0031058 positive regulation of histone modification 3/147 92/18722 0.0358825494809838 0.166653269406246 PPARGC1A/VEGFA/PIH1D1 3 GO:0006402 mRNA catabolic process 5/147 232/18722 0.0363540851040477 0.168581501622026 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0016049 cell growth 8/147 482/18722 0.0366230353769154 0.169565787635223 HSPA1A/VEGFA/GJA1/SPOCK1/EPB41L3/HSPA1B/SMAD3/IGFBP4 8 GO:0019217 regulation of fatty acid metabolic process 3/147 93/18722 0.0368717484774363 0.170149820966594 PPARGC1A/SNCA/IRS2 3 GO:0060993 kidney morphogenesis 3/147 93/18722 0.0368717484774363 0.170149820966594 SHH/VEGFA/MYC 3 GO:0006163 purine nucleotide metabolic process 7/147 396/18722 0.0369767247169128 0.170149820966594 PPARGC1A/SNCA/AK4/PRKAA2/SLC35B2/PKM/HIF1A 7 GO:0019693 ribose phosphate metabolic process 7/147 396/18722 0.0369767247169128 0.170149820966594 PPARGC1A/SNCA/AK4/PRKAA2/SLC35B2/PKM/HIF1A 7 GO:0045923 positive regulation of fatty acid metabolic process 2/147 39/18722 0.0375442153208174 0.171442363396282 PPARGC1A/IRS2 2 GO:0046621 negative regulation of organ growth 2/147 39/18722 0.0375442153208174 0.171442363396282 STK4/GJA1 2 GO:0051084 'de novo' posttranslational protein folding 2/147 39/18722 0.0375442153208174 0.171442363396282 HSPA1A/HSPA1B 2 GO:0090224 regulation of spindle organization 2/147 39/18722 0.0375442153208174 0.171442363396282 HSPA1A/HSPA1B 2 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 2/147 39/18722 0.0375442153208174 0.171442363396282 SOCS1/CD55 2 GO:0032091 negative regulation of protein binding 3/147 94/18722 0.037874873665564 0.172163749443316 IFIT1/DAB2/DKK1 3 GO:0061326 renal tubule development 3/147 94/18722 0.037874873665564 0.172163749443316 SHH/VEGFA/MYC 3 GO:1903035 negative regulation of response to wounding 3/147 94/18722 0.037874873665564 0.172163749443316 GJA1/PLAT/SMAD3 3 GO:0048762 mesenchymal cell differentiation 5/147 236/18722 0.0386728170561788 0.175524121115373 SHH/BCL9L/SMAD3/DAB2/HIF1A 5 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 3/147 95/18722 0.0388918828907318 0.176250942009362 HSPA1A/HSPA1B/GCLC 3 GO:0019058 viral life cycle 6/147 317/18722 0.0392349095905741 0.177121498965125 MX1/PLSCR1/HSPA1A/IFIT1/CD55/HSPA1B 6 GO:0031334 positive regulation of protein-containing complex assembly 5/147 237/18722 0.0392663353816887 0.177121498965125 SNCA/HSPA1A/VEGFA/HSPA1B/PIH1D1 5 GO:0033673 negative regulation of kinase activity 5/147 237/18722 0.0392663353816887 0.177121498965125 DEPTOR/SNCA/SH3BP5/HEXIM1/IRS2 5 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 2/147 40/18722 0.0393208543339495 0.177121498965125 HSPA1A/GCLC 2 GO:0006091 generation of precursor metabolites and energy 8/147 490/18722 0.0397266194437083 0.178476809396062 PPARGC1A/SNCA/AK4/PRKAA2/IRS2/MYC/PKM/HIF1A 8 GO:0015980 energy derivation by oxidation of organic compounds 6/147 318/18722 0.0397410749106576 0.178476809396062 PPARGC1A/SNCA/AK4/IRS2/MYC/HIF1A 6 GO:0015914 phospholipid transport 3/147 96/18722 0.0399227319953866 0.178755825446409 PLSCR1/ATP11A/PRELID3B 3 GO:0034620 cellular response to unfolded protein 3/147 96/18722 0.0399227319953866 0.178755825446409 HSPA1A/PPP1R15A/HSPA1B 3 GO:1904951 positive regulation of establishment of protein localization 6/147 319/18722 0.0402513860672367 0.179957990623475 SHH/IRS2/GJA1/ZFAND1/SMAD3/HIF1A 6 GO:0051403 stress-activated MAPK cascade 5/147 239/18722 0.0404700346914461 0.180164128591841 VEGFA/MAP3K4/SMAD3/MYC/IGFBP6 5 GO:0050792 regulation of viral process 4/147 164/18722 0.0404781994027808 0.180164128591841 MX1/PLSCR1/HEXIM1/IFIT1 4 GO:2001242 regulation of intrinsic apoptotic signaling pathway 4/147 164/18722 0.0404781994027808 0.180164128591841 BDKRB2/HSPA1A/SOD2/HIF1A 4 GO:0009895 negative regulation of catabolic process 6/147 320/18722 0.0407658510390102 0.181174829803387 PPARGC1A/SNCA/SHH/ALAD/TOB1/SMAD3 6 GO:0070167 regulation of biomineral tissue development 3/147 97/18722 0.0409673748662616 0.181262452995545 SMAD3/HIF1A/CEBPB 3 GO:1901216 positive regulation of neuron death 3/147 97/18722 0.0409673748662616 0.181262452995545 SNCA/FOS/DKK1 3 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 3/147 97/18722 0.0409673748662616 0.181262452995545 HSPA1A/HSPA1B/GCLC 3 GO:0042307 positive regulation of protein import into nucleus 2/147 41/18722 0.0411289052693862 0.18139644095838 SHH/SMAD3 2 GO:0048634 regulation of muscle organ development 2/147 41/18722 0.0411289052693862 0.18139644095838 SHH/SMAD3 2 GO:0071772 response to BMP 4/147 165/18722 0.0412402473593107 0.18139644095838 HTRA3/TOB1/SMAD3/DLX5 4 GO:0071773 cellular response to BMP stimulus 4/147 165/18722 0.0412402473593107 0.18139644095838 HTRA3/TOB1/SMAD3/DLX5 4 GO:0043010 camera-type eye development 6/147 322/18722 0.0418072733792659 0.183620491449904 SHH/VEGFA/PKNOX1/TSKU/SMAD3/HIF1A 6 GO:0043112 receptor metabolic process 4/147 166/18722 0.0420104262365385 0.184039617234677 SNCA/ATAD1/VEGFA/DKK1 4 GO:0003333 amino acid transmembrane transport 3/147 98/18722 0.0420257634808708 0.184039617234677 SLC15A4/SLC7A2/SLC25A29 3 GO:1903320 regulation of protein modification by small protein conjugation or removal 5/147 242/18722 0.0423173557509653 0.185045630191721 HSPA1A/HSPA1B/GCLC/DCUN1D1/HIF1A 5 GO:0002696 positive regulation of leukocyte activation 7/147 409/18722 0.0427679009246657 0.186011058049543 SOCS1/IGKC/SHH/HLA-F/CBFB/IRS2/CD55 7 GO:0009451 RNA modification 4/147 167/18722 0.0427887356380986 0.186011058049543 DUS1L/PCIF1/ALKBH5/RBM15B 4 GO:0007520 myoblast fusion 2/147 42/18722 0.0429677727252362 0.186011058049543 PTGFRN/MYOF 2 GO:0043507 positive regulation of JUN kinase activity 2/147 42/18722 0.0429677727252362 0.186011058049543 MAP3K4/DKK1 2 GO:0051602 response to electrical stimulus 2/147 42/18722 0.0429677727252362 0.186011058049543 PPARGC1A/SOD2 2 GO:1903432 regulation of TORC1 signaling 2/147 42/18722 0.0429677727252362 0.186011058049543 DEPTOR/PIH1D1 2 GO:0010717 regulation of epithelial to mesenchymal transition 3/147 99/18722 0.0430978479533043 0.186011058049543 BCL9L/SMAD3/DAB2 3 GO:0051153 regulation of striated muscle cell differentiation 3/147 99/18722 0.0430978479533043 0.186011058049543 SHH/ATP11A/DKK1 3 GO:0110149 regulation of biomineralization 3/147 99/18722 0.0430978479533043 0.186011058049543 SMAD3/HIF1A/CEBPB 3 GO:0002706 regulation of lymphocyte mediated immunity 4/147 168/18722 0.0435751743933991 0.187267681047898 SLC15A4/HLA-F/CD55/C4BPA 4 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/147 168/18722 0.0435751743933991 0.187267681047898 SLC15A4/HLA-F/CD55/C4BPA 4 GO:0006898 receptor-mediated endocytosis 5/147 244/18722 0.0435768325006143 0.187267681047898 SNCA/ATAD1/VEGFA/DAB2/DKK1 5 GO:0009062 fatty acid catabolic process 3/147 100/18722 0.044183576579332 0.189045433085207 MCAT/LPIN3/IRS2 3 GO:0044728 DNA methylation or demethylation 3/147 100/18722 0.044183576579332 0.189045433085207 FOS/MOV10L1/MYC 3 GO:0098656 anion transmembrane transport 5/147 245/18722 0.044214968422883 0.189045433085207 SLC15A4/SLC35B2/GJA1/SLC7A2/SLC25A29 5 GO:0009152 purine ribonucleotide biosynthetic process 4/147 169/18722 0.0443697405636294 0.189045433085207 PPARGC1A/SNCA/AK4/SLC35B2 4 GO:0018394 peptidyl-lysine acetylation 4/147 169/18722 0.0443697405636294 0.189045433085207 PPARGC1A/SNCA/PRKAA2/PIH1D1 4 GO:0031214 biomineral tissue development 4/147 169/18722 0.0443697405636294 0.189045433085207 WDR72/SMAD3/HIF1A/CEBPB 4 GO:0006458 'de novo' protein folding 2/147 43/18722 0.0448368685997277 0.190045895450894 HSPA1A/HSPA1B 2 GO:0035794 positive regulation of mitochondrial membrane permeability 2/147 43/18722 0.0448368685997277 0.190045895450894 HSPA1A/GCLC 2 GO:1904591 positive regulation of protein import 2/147 43/18722 0.0448368685997277 0.190045895450894 SHH/SMAD3 2 GO:0003007 heart morphogenesis 5/147 246/18722 0.0448587101933571 0.190045895450894 SHH/VEGFA/SMAD3/HIF1A/DKK1 5 GO:0007259 receptor signaling pathway via JAK-STAT 4/147 170/18722 0.0451724314478289 0.191031229308244 SOCS1/GH2/PARP9/SOCS3 4 GO:0006476 protein deacetylation 3/147 101/18722 0.0452828958808242 0.191031229308244 NNMT/PRKAA2/VEGFA 3 GO:0051963 regulation of synapse assembly 3/147 101/18722 0.0452828958808242 0.191031229308244 SNCA/SLITRK4/TPBG 3 GO:0031098 stress-activated protein kinase signaling cascade 5/147 247/18722 0.0455080629741119 0.191710727261365 VEGFA/MAP3K4/SMAD3/MYC/IGFBP6 5 GO:0051048 negative regulation of secretion 4/147 171/18722 0.0459832435890151 0.193168372998236 SNCA/SLC30A1/HLA-F/GJA1 4 GO:0110148 biomineralization 4/147 171/18722 0.0459832435890151 0.193168372998236 WDR72/SMAD3/HIF1A/CEBPB 4 GO:0035710 CD4-positive, alpha-beta T cell activation 3/147 102/18722 0.0463957506494985 0.19462789648338 SOCS1/CBFB/CD55 3 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 2/147 44/18722 0.0467356120145717 0.195232144602771 SOCS1/GH2 2 GO:0051150 regulation of smooth muscle cell differentiation 2/147 44/18722 0.0467356120145717 0.195232144602771 SHH/SOD2 2 GO:1903573 negative regulation of response to endoplasmic reticulum stress 2/147 44/18722 0.0467356120145717 0.195232144602771 HSPA1A/PPP1R15A 2 GO:0019395 fatty acid oxidation 3/147 103/18722 0.0475220839900003 0.197689225610697 PPARGC1A/MCAT/IRS2 3 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 3/147 103/18722 0.0475220839900003 0.197689225610697 SOCS1/GH2/SOCS3 3 GO:0090277 positive regulation of peptide hormone secretion 3/147 103/18722 0.0475220839900003 0.197689225610697 IRS2/GJA1/HIF1A 3 GO:0034329 cell junction assembly 7/147 420/18722 0.0481051761557373 0.199559752956741 SNCA/SLITRK4/TPBG/VEGFA/GJA1/EPB41L3/SMAD3 7 GO:0050867 positive regulation of cell activation 7/147 420/18722 0.0481051761557373 0.199559752956741 SOCS1/IGKC/SHH/HLA-F/CBFB/IRS2/CD55 7 GO:0001659 temperature homeostasis 4/147 174/18722 0.0484643617745962 0.200209514242153 PPARGC1A/VEGFA/GJA1/CEBPB 4 GO:0045621 positive regulation of lymphocyte differentiation 3/147 104/18722 0.0486618373623271 0.200209514242153 SOCS1/SHH/CBFB 3 GO:0002920 regulation of humoral immune response 2/147 45/18722 0.0486634292390657 0.200209514242153 CD55/C4BPA 2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 2/147 45/18722 0.0486634292390657 0.200209514242153 SOD2/HIF1A 2 GO:0035272 exocrine system development 2/147 45/18722 0.0486634292390657 0.200209514242153 SHH/TFCP2L1 2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 2/147 45/18722 0.0486634292390657 0.200209514242153 HSPA1A/GCLC 2 GO:0052126 movement in host environment 4/147 175/18722 0.0493076094710514 0.202581126274608 PLSCR1/HSPA1A/CD55/HSPA1B 4 GO:0062207 regulation of pattern recognition receptor signaling pathway 3/147 105/18722 0.0498149506236017 0.20438479741453 SLC15A4/HSPA1A/HSPA1B 3 GO:0010634 positive regulation of epithelial cell migration 4/147 176/18722 0.0501589500175615 0.205514273291132 ATOH8/CTSH/VEGFA/HIF1A 4 GO:0031057 negative regulation of histone modification 2/147 46/18722 0.0506197536149322 0.205991405526888 SNCA/PIH1D1 2 GO:0031648 protein destabilization 2/147 46/18722 0.0506197536149322 0.205991405526888 SNCA/CTSH 2 GO:0032924 activin receptor signaling pathway 2/147 46/18722 0.0506197536149322 0.205991405526888 SHH/SMAD3 2 GO:0042398 cellular modified amino acid biosynthetic process 2/147 46/18722 0.0506197536149322 0.205991405526888 PLSCR1/GCLC 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/147 46/18722 0.0506197536149322 0.205991405526888 IRS2/HIF1A 2 GO:0001655 urogenital system development 6/147 338/18722 0.0507444596429498 0.206210758483963 SHH/CTSH/VEGFA/SMAD3/BICC1/MYC 6 GO:0002062 chondrocyte differentiation 3/147 106/18722 0.0509813620692062 0.206210758483963 TSKU/SLC39A14/SMAD3 3 GO:0002793 positive regulation of peptide secretion 3/147 106/18722 0.0509813620692062 0.206210758483963 IRS2/GJA1/HIF1A 3 GO:2000278 regulation of DNA biosynthetic process 3/147 106/18722 0.0509813620692062 0.206210758483963 GJA1/MAP3K4/MYC 3 GO:0030324 lung development 4/147 177/18722 0.0510183755527024 0.206210758483963 SHH/CTSH/VEGFA/RXFP1 4 GO:0034976 response to endoplasmic reticulum stress 5/147 256/18722 0.0516054079567819 0.208301990821504 HSPA1A/PPP1R15A/NRBF2/SRPX/CEBPB 5 GO:0043254 regulation of protein-containing complex assembly 7/147 427/18722 0.0517140591707612 0.208459233126343 SNCA/HSPA1A/VEGFA/PMEPA1/HSPA1B/PIH1D1/DKK1 7 GO:0035265 organ growth 4/147 178/18722 0.0518858775033742 0.208870335952345 SHH/STK4/GJA1/TSKU 4 GO:0008637 apoptotic mitochondrial changes 3/147 107/18722 0.0521610084732815 0.209226915181264 HSPA1A/GCLC/SOD2 3 GO:0007595 lactation 2/147 47/18722 0.0526040254818825 0.209226915181264 VEGFA/HIF1A 2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 2/147 47/18722 0.0526040254818825 0.209226915181264 HSPA1A/HSPA1B 2 GO:0032369 negative regulation of lipid transport 2/147 47/18722 0.0526040254818825 0.209226915181264 SHH/IRS2 2 GO:0043114 regulation of vascular permeability 2/147 47/18722 0.0526040254818825 0.209226915181264 BDKRB2/VEGFA 2 GO:0045332 phospholipid translocation 2/147 47/18722 0.0526040254818825 0.209226915181264 PLSCR1/ATP11A 2 GO:0045601 regulation of endothelial cell differentiation 2/147 47/18722 0.0526040254818825 0.209226915181264 ATOH8/VEGFA 2 GO:0051972 regulation of telomerase activity 2/147 47/18722 0.0526040254818825 0.209226915181264 MAP3K4/MYC 2 GO:1900744 regulation of p38MAPK cascade 2/147 47/18722 0.0526040254818825 0.209226915181264 VEGFA/MAP3K4 2 GO:0001936 regulation of endothelial cell proliferation 4/147 179/18722 0.0527614465913157 0.209296401531333 ATOH8/VEGFA/GJA1/HIF1A 4 GO:0010950 positive regulation of endopeptidase activity 4/147 179/18722 0.0527614465913157 0.209296401531333 SNCA/CTSH/SMAD3/MYC 4 GO:0033138 positive regulation of peptidyl-serine phosphorylation 3/147 108/18722 0.0533538251286032 0.211086363703244 SNCA/STK4/VEGFA 3 GO:0034440 lipid oxidation 3/147 108/18722 0.0533538251286032 0.211086363703244 PPARGC1A/MCAT/IRS2 3 GO:0030323 respiratory tube development 4/147 181/18722 0.0545367455795036 0.213816145396296 SHH/CTSH/VEGFA/RXFP1 4 GO:0045766 positive regulation of angiogenesis 4/147 181/18722 0.0545367455795036 0.213816145396296 CTSH/VEGFA/PKM/HIF1A 4 GO:0097696 receptor signaling pathway via STAT 4/147 181/18722 0.0545367455795036 0.213816145396296 SOCS1/GH2/PARP9/SOCS3 4 GO:1904018 positive regulation of vasculature development 4/147 181/18722 0.0545367455795036 0.213816145396296 CTSH/VEGFA/PKM/HIF1A 4 GO:0002456 T cell mediated immunity 3/147 109/18722 0.0545597458858388 0.213816145396296 HLA-F/CTSH/CD55 3 GO:0072009 nephron epithelium development 3/147 109/18722 0.0545597458858388 0.213816145396296 SHH/VEGFA/MYC 3 GO:0006111 regulation of gluconeogenesis 2/147 48/18722 0.0546156921039018 0.213816145396296 PPARGC1A/NNMT 2 GO:1905710 positive regulation of membrane permeability 2/147 48/18722 0.0546156921039018 0.213816145396296 HSPA1A/GCLC 2 GO:0009260 ribonucleotide biosynthetic process 4/147 182/18722 0.055436453456567 0.216745663122342 PPARGC1A/SNCA/AK4/SLC35B2 4 GO:0002698 negative regulation of immune effector process 3/147 110/18722 0.0557787031921968 0.217515125486128 HLA-F/CD55/C4BPA 3 GO:0009408 response to heat 3/147 110/18722 0.0557787031921968 0.217515125486128 HSPA1A/HSPA1B/GCLC 3 GO:0002819 regulation of adaptive immune response 4/147 183/18722 0.0563441844378091 0.219214404812906 SLC15A4/HLA-F/CD55/C4BPA 4 GO:0001913 T cell mediated cytotoxicity 2/147 49/18722 0.0566542075962476 0.219214404812906 HLA-F/CTSH 2 GO:0006953 acute-phase response 2/147 49/18722 0.0566542075962476 0.219214404812906 PLSCR1/CEBPB 2 GO:0070169 positive regulation of biomineral tissue development 2/147 49/18722 0.0566542075962476 0.219214404812906 SMAD3/CEBPB 2 GO:1901799 negative regulation of proteasomal protein catabolic process 2/147 49/18722 0.0566542075962476 0.219214404812906 SHH/ALAD 2 GO:1904894 positive regulation of receptor signaling pathway via STAT 2/147 49/18722 0.0566542075962476 0.219214404812906 SOCS1/GH2 2 GO:0045785 positive regulation of cell adhesion 7/147 437/18722 0.0571599503087203 0.220885544410055 SOCS1/SHH/STK4/CBFB/VEGFA/CD55/SMAD3 7 GO:0015833 peptide transport 5/147 264/18722 0.0574088191726471 0.221561004058565 SLC15A4/SLC15A1/IRS2/GJA1/HIF1A 5 GO:0007369 gastrulation 4/147 185/18722 0.0581836642270806 0.223162169331367 ATOH8/GJA1/SMAD3/DKK1 4 GO:0002526 acute inflammatory response 3/147 112/18722 0.0582554504515059 0.223162169331367 PLSCR1/B4GALT1/CEBPB 3 GO:0035601 protein deacylation 3/147 112/18722 0.0582554504515059 0.223162169331367 NNMT/PRKAA2/VEGFA 3 GO:0043406 positive regulation of MAP kinase activity 3/147 112/18722 0.0582554504515059 0.223162169331367 VEGFA/MAP3K4/DKK1 3 GO:0046632 alpha-beta T cell differentiation 3/147 112/18722 0.0582554504515059 0.223162169331367 SOCS1/SHH/CBFB 3 GO:0038202 TORC1 signaling 2/147 50/18722 0.0587190328531547 0.223162169331367 DEPTOR/PIH1D1 2 GO:0050873 brown fat cell differentiation 2/147 50/18722 0.0587190328531547 0.223162169331367 PPARGC1A/CEBPB 2 GO:0060425 lung morphogenesis 2/147 50/18722 0.0587190328531547 0.223162169331367 SHH/CTSH 2 GO:0060688 regulation of morphogenesis of a branching structure 2/147 50/18722 0.0587190328531547 0.223162169331367 SHH/VEGFA 2 GO:0071709 membrane assembly 2/147 50/18722 0.0587190328531547 0.223162169331367 PACSIN2/DMKN 2 GO:0099054 presynapse assembly 2/147 50/18722 0.0587190328531547 0.223162169331367 SNCA/SLITRK4 2 GO:0110151 positive regulation of biomineralization 2/147 50/18722 0.0587190328531547 0.223162169331367 SMAD3/CEBPB 2 GO:0002443 leukocyte mediated immunity 7/147 440/18722 0.0588608155155308 0.22341713097329 CFI/IGKC/SLC15A4/HLA-F/CTSH/CD55/C4BPA 7 GO:0051348 negative regulation of transferase activity 5/147 268/18722 0.060445976116062 0.229070050011889 DEPTOR/SNCA/SH3BP5/HEXIM1/IRS2 5 GO:1903008 organelle disassembly 3/147 114/18722 0.0607834998460074 0.229070050011889 PPARGC1A/ZFAND1/HIF1A 3 GO:1904892 regulation of receptor signaling pathway via STAT 3/147 114/18722 0.0607834998460074 0.229070050011889 SOCS1/GH2/SOCS3 3 GO:0009948 anterior/posterior axis specification 2/147 51/18722 0.0608096354762419 0.229070050011889 SHH/HOXD8 2 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 2/147 51/18722 0.0608096354762419 0.229070050011889 SOCS1/CBFB 2 GO:0045668 negative regulation of osteoblast differentiation 2/147 51/18722 0.0608096354762419 0.229070050011889 TOB1/SMAD3 2 GO:0030308 negative regulation of cell growth 4/147 188/18722 0.0610027180825754 0.22950833935218 HSPA1A/GJA1/HSPA1B/SMAD3 4 GO:0030278 regulation of ossification 3/147 115/18722 0.0620665801152625 0.233217513975817 SMAD3/HIF1A/DKK1 3 GO:0009755 hormone-mediated signaling pathway 4/147 190/18722 0.0629217980117356 0.233801415780748 PMEPA1/RXFP1/PIAS2/DAB2 4 GO:0046390 ribose phosphate biosynthetic process 4/147 190/18722 0.0629217980117356 0.233801415780748 PPARGC1A/SNCA/AK4/SLC35B2 4 GO:0051216 cartilage development 4/147 190/18722 0.0629217980117356 0.233801415780748 TSKU/SLC39A14/SMAD3/HIF1A 4 GO:0030514 negative regulation of BMP signaling pathway 2/147 52/18722 0.0629254897036116 0.233801415780748 HTRA3/TOB1 2 GO:0034204 lipid translocation 2/147 52/18722 0.0629254897036116 0.233801415780748 PLSCR1/ATP11A 2 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 2/147 52/18722 0.0629254897036116 0.233801415780748 DAB2/DKK1 2 GO:0071357 cellular response to type I interferon 2/147 52/18722 0.0629254897036116 0.233801415780748 IFIT1/YTHDF2 2 GO:0072132 mesenchyme morphogenesis 2/147 52/18722 0.0629254897036116 0.233801415780748 SMAD3/MYC 2 GO:1903426 regulation of reactive oxygen species biosynthetic process 2/147 52/18722 0.0629254897036116 0.233801415780748 SNCA/SOD2 2 GO:0007006 mitochondrial membrane organization 3/147 116/18722 0.0633622642337119 0.234260237729335 SNCA/HSPA1A/GCLC 3 GO:0030518 intracellular steroid hormone receptor signaling pathway 3/147 116/18722 0.0633622642337119 0.234260237729335 PMEPA1/PIAS2/DAB2 3 GO:0035967 cellular response to topologically incorrect protein 3/147 116/18722 0.0633622642337119 0.234260237729335 HSPA1A/PPP1R15A/HSPA1B 3 GO:0098732 macromolecule deacylation 3/147 116/18722 0.0633622642337119 0.234260237729335 NNMT/PRKAA2/VEGFA 3 GO:0022407 regulation of cell-cell adhesion 7/147 448/18722 0.0635487549314756 0.234460809983852 SOCS1/SHH/CBFB/VEGFA/CD55/YTHDF2/CEBPB 7 GO:0051962 positive regulation of nervous system development 5/147 272/18722 0.0635732921754946 0.234460809983852 SHH/SLITRK4/TPBG/VEGFA/HIF1A 5 GO:0006164 purine nucleotide biosynthetic process 4/147 191/18722 0.0638932014050766 0.235350450003182 PPARGC1A/SNCA/AK4/SLC35B2 4 GO:0051052 regulation of DNA metabolic process 6/147 359/18722 0.0641332601146649 0.235944134074985 PPARGC1A/SLC15A4/PARP9/GJA1/MAP3K4/MYC 6 GO:0032872 regulation of stress-activated MAPK cascade 4/147 192/18722 0.0648724901727711 0.237332480892509 VEGFA/MAP3K4/MYC/IGFBP6 4 GO:0001541 ovarian follicle development 2/147 53/18722 0.065066076339638 0.237332480892509 VEGFA/CEBPB 2 GO:0007566 embryo implantation 2/147 53/18722 0.065066076339638 0.237332480892509 VEGFA/GJA1 2 GO:0016925 protein sumoylation 2/147 53/18722 0.065066076339638 0.237332480892509 CBX4/PIAS2 2 GO:0032784 regulation of DNA-templated transcription, elongation 2/147 53/18722 0.065066076339638 0.237332480892509 SHH/HEXIM1 2 GO:0099172 presynapse organization 2/147 53/18722 0.065066076339638 0.237332480892509 SNCA/SLITRK4 2 GO:1903202 negative regulation of oxidative stress-induced cell death 2/147 53/18722 0.065066076339638 0.237332480892509 SOD2/HIF1A 2 GO:0001935 endothelial cell proliferation 4/147 193/18722 0.0658596458658834 0.239934471114321 ATOH8/VEGFA/GJA1/HIF1A 4 GO:0050777 negative regulation of immune response 4/147 194/18722 0.0668546494314741 0.243128123916563 HLA-F/CD55/C4BPA/YTHDF2 4 GO:0051098 regulation of binding 6/147 363/18722 0.0668988451967005 0.243128123916563 STK4/IFIT1/PARP9/SMAD3/DAB2/DKK1 6 GO:0014888 striated muscle adaptation 2/147 54/18722 0.0672308826854363 0.243153047294002 PPARGC1A/SMAD3 2 GO:0060350 endochondral bone morphogenesis 2/147 54/18722 0.0672308826854363 0.243153047294002 TSKU/DLX5 2 GO:0070228 regulation of lymphocyte apoptotic process 2/147 54/18722 0.0672308826854363 0.243153047294002 IRS2/HIF1A 2 GO:0072348 sulfur compound transport 2/147 54/18722 0.0672308826854363 0.243153047294002 SLC35B2/GJA1 2 GO:0070302 regulation of stress-activated protein kinase signaling cascade 4/147 195/18722 0.06785748121949 0.245122857883448 VEGFA/MAP3K4/MYC/IGFBP6 4 GO:0006401 RNA catabolic process 5/147 278/18722 0.0684328244948987 0.246863535916997 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0002761 regulation of myeloid leukocyte differentiation 3/147 120/18722 0.0686694957816588 0.246863535916997 FOS/MYC/CEBPB 3 GO:0006304 DNA modification 3/147 120/18722 0.0686694957816588 0.246863535916997 FOS/MOV10L1/MYC 3 GO:0048593 camera-type eye morphogenesis 3/147 120/18722 0.0686694957816588 0.246863535916997 VEGFA/TSKU/HIF1A 3 GO:0043393 regulation of protein binding 4/147 196/18722 0.0688681209896629 0.2472803720049 STK4/IFIT1/DAB2/DKK1 4 GO:0000768 syncytium formation by plasma membrane fusion 2/147 55/18722 0.0694194024700077 0.247772592825529 PTGFRN/MYOF 2 GO:0001755 neural crest cell migration 2/147 55/18722 0.0694194024700077 0.247772592825529 SHH/HIF1A 2 GO:0038066 p38MAPK cascade 2/147 55/18722 0.0694194024700077 0.247772592825529 VEGFA/MAP3K4 2 GO:0044091 membrane biogenesis 2/147 55/18722 0.0694194024700077 0.247772592825529 PACSIN2/DMKN 2 GO:0140253 cell-cell fusion 2/147 55/18722 0.0694194024700077 0.247772592825529 PTGFRN/MYOF 2 GO:0010952 positive regulation of peptidase activity 4/147 197/18722 0.0698865479184148 0.249142627918926 SNCA/CTSH/SMAD3/MYC 4 GO:0021700 developmental maturation 5/147 280/18722 0.0700974635813815 0.249597039966562 TFCP2L1/CBFB/VEGFA/YTHDF2/HIF1A 5 GO:0072329 monocarboxylic acid catabolic process 3/147 122/18722 0.0713966982789823 0.251304330838289 MCAT/LPIN3/IRS2 3 GO:0002711 positive regulation of T cell mediated immunity 2/147 56/18722 0.0716311357820524 0.251304330838289 HLA-F/CD55 2 GO:0015800 acidic amino acid transport 2/147 56/18722 0.0716311357820524 0.251304330838289 SNCA/GJA1 2 GO:0045599 negative regulation of fat cell differentiation 2/147 56/18722 0.0716311357820524 0.251304330838289 TRIO/SMAD3 2 GO:0090175 regulation of establishment of planar polarity 2/147 56/18722 0.0716311357820524 0.251304330838289 DAB2/DKK1 2 GO:1903532 positive regulation of secretion by cell 5/147 282/18722 0.0717844210598882 0.251304330838289 SNCA/HLA-F/IRS2/GJA1/HIF1A 5 GO:0001654 eye development 6/147 371/18722 0.0726369204861276 0.251304330838289 SHH/VEGFA/PKNOX1/TSKU/SMAD3/HIF1A 6 GO:0010811 positive regulation of cell-substrate adhesion 3/147 123/18722 0.0727784115558702 0.251304330838289 STK4/VEGFA/SMAD3 3 GO:0045216 cell-cell junction organization 4/147 200/18722 0.0729883348158905 0.251304330838289 VEGFA/GJA1/EPB41L3/SMAD3 4 GO:0006754 ATP biosynthetic process 2/147 57/18722 0.0738655890024465 0.251304330838289 PPARGC1A/AK4 2 GO:0006949 syncytium formation 2/147 57/18722 0.0738655890024465 0.251304330838289 PTGFRN/MYOF 2 GO:0051155 positive regulation of striated muscle cell differentiation 2/147 57/18722 0.0738655890024465 0.251304330838289 SHH/ATP11A 2 GO:0006473 protein acetylation 4/147 201/18722 0.0740376907189665 0.251304330838289 PPARGC1A/SNCA/PRKAA2/PIH1D1 4 GO:0051054 positive regulation of DNA metabolic process 4/147 201/18722 0.0740376907189665 0.251304330838289 PPARGC1A/PARP9/MAP3K4/MYC 4 GO:0032388 positive regulation of intracellular transport 4/147 202/18722 0.0750947211551063 0.251304330838289 SHH/ZFAND1/SMAD3/DAB2 4 GO:0001819 positive regulation of cytokine production 7/147 467/18722 0.0755748025404313 0.251304330838289 HSPA1A/HLA-F/CD55/HSPA1B/SMAD3/HIF1A/CEBPB 7 GO:0033674 positive regulation of kinase activity 7/147 467/18722 0.0755748025404313 0.251304330838289 SOCS1/SNCA/STK4/VEGFA/MAP3K4/PIH1D1/DKK1 7 GO:0002253 activation of immune response 6/147 375/18722 0.0756092288536673 0.251304330838289 CFI/IGKC/PLSCR1/HEXIM1/CD55/C4BPA 6 GO:0018108 peptidyl-tyrosine phosphorylation 6/147 375/18722 0.0756092288536673 0.251304330838289 SOCS1/GH2/SH3BP5/VEGFA/PARP9/SOCS3 6 GO:0150063 visual system development 6/147 375/18722 0.0756092288536673 0.251304330838289 SHH/VEGFA/PKNOX1/TSKU/SMAD3/HIF1A 6 GO:0000492 box C/D snoRNP assembly 1/147 10/18722 0.0758179025511896 0.251304330838289 PIH1D1 1 GO:0001672 regulation of chromatin assembly or disassembly 1/147 10/18722 0.0758179025511896 0.251304330838289 TLK1 1 GO:0003129 heart induction 1/147 10/18722 0.0758179025511896 0.251304330838289 DKK1 1 GO:0005984 disaccharide metabolic process 1/147 10/18722 0.0758179025511896 0.251304330838289 B4GALT1 1 GO:0007028 cytoplasm organization 1/147 10/18722 0.0758179025511896 0.251304330838289 TFCP2L1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/147 10/18722 0.0758179025511896 0.251304330838289 AK4 1 GO:0009750 response to fructose 1/147 10/18722 0.0758179025511896 0.251304330838289 PPARGC1A 1 GO:0010728 regulation of hydrogen peroxide biosynthetic process 1/147 10/18722 0.0758179025511896 0.251304330838289 SOD2 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/147 10/18722 0.0758179025511896 0.251304330838289 IRS2 1 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0031340 positive regulation of vesicle fusion 1/147 10/18722 0.0758179025511896 0.251304330838289 SNCA 1 GO:0032025 response to cobalt ion 1/147 10/18722 0.0758179025511896 0.251304330838289 ALAD 1 GO:0033080 immature T cell proliferation in thymus 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0033089 positive regulation of T cell differentiation in thymus 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0043101 purine-containing compound salvage 1/147 10/18722 0.0758179025511896 0.251304330838289 MTAP 1 GO:0045792 negative regulation of cell size 1/147 10/18722 0.0758179025511896 0.251304330838289 DEPTOR 1 GO:0048340 paraxial mesoderm morphogenesis 1/147 10/18722 0.0758179025511896 0.251304330838289 SMAD3 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/147 10/18722 0.0758179025511896 0.251304330838289 SLC39A14 1 GO:0051409 response to nitrosative stress 1/147 10/18722 0.0758179025511896 0.251304330838289 GCLC 1 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 1/147 10/18722 0.0758179025511896 0.251304330838289 PLSCR1 1 GO:0060439 trachea morphogenesis 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0060513 prostatic bud formation 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0060736 prostate gland growth 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/147 10/18722 0.0758179025511896 0.251304330838289 SHH 1 GO:0060923 cardiac muscle cell fate commitment 1/147 10/18722 0.0758179025511896 0.251304330838289 DKK1 1 GO:0060947 cardiac vascular smooth muscle cell differentiation 1/147 10/18722 0.0758179025511896 0.251304330838289 VEGFA 1 GO:0070099 regulation of chemokine-mediated signaling pathway 1/147 10/18722 0.0758179025511896 0.251304330838289 HIF1A 1 GO:0071421 manganese ion transmembrane transport 1/147 10/18722 0.0758179025511896 0.251304330838289 SLC39A14 1 GO:0090037 positive regulation of protein kinase C signaling 1/147 10/18722 0.0758179025511896 0.251304330838289 VEGFA 1 GO:0090043 regulation of tubulin deacetylation 1/147 10/18722 0.0758179025511896 0.251304330838289 PRKAA2 1 GO:0090647 modulation of age-related behavioral decline 1/147 10/18722 0.0758179025511896 0.251304330838289 DKK1 1 GO:0097084 vascular associated smooth muscle cell development 1/147 10/18722 0.0758179025511896 0.251304330838289 VEGFA 1 GO:0097278 complement-dependent cytotoxicity 1/147 10/18722 0.0758179025511896 0.251304330838289 CD55 1 GO:0140059 dendrite arborization 1/147 10/18722 0.0758179025511896 0.251304330838289 TPBG 1 GO:1901203 positive regulation of extracellular matrix assembly 1/147 10/18722 0.0758179025511896 0.251304330838289 SMAD3 1 GO:1901725 regulation of histone deacetylase activity 1/147 10/18722 0.0758179025511896 0.251304330838289 VEGFA 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/147 10/18722 0.0758179025511896 0.251304330838289 PIH1D1 1 GO:1903867 extraembryonic membrane development 1/147 10/18722 0.0758179025511896 0.251304330838289 MAP3K4 1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin 1/147 10/18722 0.0758179025511896 0.251304330838289 VEGFA 1 GO:2000726 negative regulation of cardiac muscle cell differentiation 1/147 10/18722 0.0758179025511896 0.251304330838289 DKK1 1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/147 10/18722 0.0758179025511896 0.251304330838289 SMAD3 1 GO:0001954 positive regulation of cell-matrix adhesion 2/147 58/18722 0.0761222747373753 0.251304330838289 VEGFA/SMAD3 2 GO:0002931 response to ischemia 2/147 58/18722 0.0761222747373753 0.251304330838289 PPARGC1A/GJA1 2 GO:0006826 iron ion transport 2/147 58/18722 0.0761222747373753 0.251304330838289 SLC25A37/SLC39A14 2 GO:0043506 regulation of JUN kinase activity 2/147 58/18722 0.0761222747373753 0.251304330838289 MAP3K4/DKK1 2 GO:0097035 regulation of membrane lipid distribution 2/147 58/18722 0.0761222747373753 0.251304330838289 PLSCR1/ATP11A 2 GO:0032874 positive regulation of stress-activated MAPK cascade 3/147 126/18722 0.0769949953158644 0.253905216085723 VEGFA/MAP3K4/IGFBP6 3 GO:0018212 peptidyl-tyrosine modification 6/147 378/18722 0.0778835198040081 0.255382229579843 SOCS1/GH2/SH3BP5/VEGFA/PARP9/SOCS3 6 GO:0006406 mRNA export from nucleus 2/147 59/18722 0.0784007117521165 0.255382229579843 ALKBH5/RBM15B 2 GO:0006767 water-soluble vitamin metabolic process 2/147 59/18722 0.0784007117521165 0.255382229579843 NNMT/GCLC 2 GO:0032768 regulation of monooxygenase activity 2/147 59/18722 0.0784007117521165 0.255382229579843 SNCA/HIF1A 2 GO:0035306 positive regulation of dephosphorylation 2/147 59/18722 0.0784007117521165 0.255382229579843 PPP1R15A/SMAD3 2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/147 59/18722 0.0784007117521165 0.255382229579843 SOCS1/SOCS3 2 GO:0048010 vascular endothelial growth factor receptor signaling pathway 2/147 59/18722 0.0784007117521165 0.255382229579843 VEGFA/HIF1A 2 GO:0051353 positive regulation of oxidoreductase activity 2/147 59/18722 0.0784007117521165 0.255382229579843 SNCA/HIF1A 2 GO:0051568 histone H3-K4 methylation 2/147 59/18722 0.0784007117521165 0.255382229579843 NNMT/PIH1D1 2 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 2/147 59/18722 0.0784007117521165 0.255382229579843 ALKBH5/RBM15B 2 GO:0048565 digestive tract development 3/147 127/18722 0.0784240538406565 0.255382229579843 SHH/SMAD3/HIF1A 3 GO:0050878 regulation of body fluid levels 6/147 379/18722 0.0786501833152018 0.255382229579843 PLSCR1/SHH/VEGFA/GJA1/PLAT/HIF1A 6 GO:0044403 biological process involved in symbiotic interaction 5/147 290/18722 0.0787542601736375 0.255382229579843 PLSCR1/HSPA1A/IFIT1/CD55/HSPA1B 5 GO:0019221 cytokine-mediated signaling pathway 7/147 472/18722 0.0789486573655137 0.255382229579843 SOCS1/MX1/HSPA1A/PARP9/YTHDF2/HSPA1B/HIF1A 7 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 3/147 128/18722 0.0798647335815757 0.255382229579843 VEGFA/MAP3K4/IGFBP6 3 GO:0048880 sensory system development 6/147 381/18722 0.0801963390835104 0.255382229579843 SHH/VEGFA/PKNOX1/TSKU/SMAD3/HIF1A 6 GO:0010632 regulation of epithelial cell migration 5/147 292/18722 0.0805518857516898 0.255382229579843 ATOH8/MCC/CTSH/VEGFA/HIF1A 5 GO:0031638 zymogen activation 2/147 60/18722 0.0807004249054696 0.255382229579843 CTSH/PLAT 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/147 60/18722 0.0807004249054696 0.255382229579843 SNCA/SLC35B2 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/147 60/18722 0.0807004249054696 0.255382229579843 SNCA/SLC35B2 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/147 60/18722 0.0807004249054696 0.255382229579843 SNCA/SLC35B2 2 GO:0042306 regulation of protein import into nucleus 2/147 60/18722 0.0807004249054696 0.255382229579843 SHH/SMAD3 2 GO:0051965 positive regulation of synapse assembly 2/147 60/18722 0.0807004249054696 0.255382229579843 SLITRK4/TPBG 2 GO:1903670 regulation of sprouting angiogenesis 2/147 60/18722 0.0807004249054696 0.255382229579843 VEGFA/PKM 2 GO:0002573 myeloid leukocyte differentiation 4/147 208/18722 0.0815966779318908 0.255382229579843 FOS/VEGFA/MYC/CEBPB 4 GO:0006352 DNA-templated transcription, initiation 3/147 130/18722 0.0827806054380388 0.255382229579843 PPARGC1A/CCNH/PIH1D1 3 GO:0001765 membrane raft assembly 1/147 11/18722 0.0830782044069499 0.255382229579843 PACSIN2 1 GO:0002725 negative regulation of T cell cytokine production 1/147 11/18722 0.0830782044069499 0.255382229579843 HLA-F 1 GO:0003093 regulation of glomerular filtration 1/147 11/18722 0.0830782044069499 0.255382229579843 GJA1 1 GO:0003157 endocardium development 1/147 11/18722 0.0830782044069499 0.255382229579843 STK4 1 GO:0021889 olfactory bulb interneuron differentiation 1/147 11/18722 0.0830782044069499 0.255382229579843 DLX5 1 GO:0032000 positive regulation of fatty acid beta-oxidation 1/147 11/18722 0.0830782044069499 0.255382229579843 IRS2 1 GO:0032276 regulation of gonadotropin secretion 1/147 11/18722 0.0830782044069499 0.255382229579843 GJA1 1 GO:0033083 regulation of immature T cell proliferation 1/147 11/18722 0.0830782044069499 0.255382229579843 SHH 1 GO:0033197 response to vitamin E 1/147 11/18722 0.0830782044069499 0.255382229579843 ALAD 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/147 11/18722 0.0830782044069499 0.255382229579843 SLC15A4 1 GO:0035404 histone-serine phosphorylation 1/147 11/18722 0.0830782044069499 0.255382229579843 PRKAA2 1 GO:0035865 cellular response to potassium ion 1/147 11/18722 0.0830782044069499 0.255382229579843 PPARGC1A 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/147 11/18722 0.0830782044069499 0.255382229579843 PPP1R15A 1 GO:0042135 neurotransmitter catabolic process 1/147 11/18722 0.0830782044069499 0.255382229579843 ALDH5A1 1 GO:0042416 dopamine biosynthetic process 1/147 11/18722 0.0830782044069499 0.255382229579843 SNCA 1 GO:0042451 purine nucleoside biosynthetic process 1/147 11/18722 0.0830782044069499 0.255382229579843 MTAP 1 GO:0042455 ribonucleoside biosynthetic process 1/147 11/18722 0.0830782044069499 0.255382229579843 MTAP 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/147 11/18722 0.0830782044069499 0.255382229579843 HIF1A 1 GO:0045060 negative thymic T cell selection 1/147 11/18722 0.0830782044069499 0.255382229579843 SHH 1 GO:0046129 purine ribonucleoside biosynthetic process 1/147 11/18722 0.0830782044069499 0.255382229579843 MTAP 1 GO:0046501 protoporphyrinogen IX metabolic process 1/147 11/18722 0.0830782044069499 0.255382229579843 ALAD 1 GO:0046929 negative regulation of neurotransmitter secretion 1/147 11/18722 0.0830782044069499 0.255382229579843 SLC30A1 1 GO:0046940 nucleoside monophosphate phosphorylation 1/147 11/18722 0.0830782044069499 0.255382229579843 AK4 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/147 11/18722 0.0830782044069499 0.255382229579843 PIH1D1 1 GO:0051610 serotonin uptake 1/147 11/18722 0.0830782044069499 0.255382229579843 SNCA 1 GO:0060174 limb bud formation 1/147 11/18722 0.0830782044069499 0.255382229579843 SHH 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/147 11/18722 0.0830782044069499 0.255382229579843 SHH 1 GO:0070243 regulation of thymocyte apoptotic process 1/147 11/18722 0.0830782044069499 0.255382229579843 HIF1A 1 GO:0071313 cellular response to caffeine 1/147 11/18722 0.0830782044069499 0.255382229579843 PPARGC1A 1 GO:0071679 commissural neuron axon guidance 1/147 11/18722 0.0830782044069499 0.255382229579843 VEGFA 1 GO:0072205 metanephric collecting duct development 1/147 11/18722 0.0830782044069499 0.255382229579843 SHH 1 GO:0098883 synapse pruning 1/147 11/18722 0.0830782044069499 0.255382229579843 DKK1 1 GO:0099550 trans-synaptic signaling, modulating synaptic transmission 1/147 11/18722 0.0830782044069499 0.255382229579843 PLAT 1 GO:0106049 regulation of cellular response to osmotic stress 1/147 11/18722 0.0830782044069499 0.255382229579843 BDKRB2 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/147 11/18722 0.0830782044069499 0.255382229579843 PIH1D1 1 GO:1902667 regulation of axon guidance 1/147 11/18722 0.0830782044069499 0.255382229579843 VEGFA 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/147 11/18722 0.0830782044069499 0.255382229579843 PPP1R15A 1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1/147 11/18722 0.0830782044069499 0.255382229579843 CEBPB 1 GO:2000615 regulation of histone H3-K9 acetylation 1/147 11/18722 0.0830782044069499 0.255382229579843 PIH1D1 1 GO:2000826 regulation of heart morphogenesis 1/147 11/18722 0.0830782044069499 0.255382229579843 DKK1 1 GO:0031396 regulation of protein ubiquitination 4/147 210/18722 0.083824235864665 0.25741097481644 HSPA1A/HSPA1B/GCLC/DCUN1D1 4 GO:0019079 viral genome replication 3/147 131/18722 0.0842556200761872 0.25840481142415 MX1/PLSCR1/IFIT1 3 GO:0032757 positive regulation of interleukin-8 production 2/147 62/18722 0.0853618091418538 0.25840481142415 HSPA1A/HSPA1B 2 GO:0045576 mast cell activation 2/147 62/18722 0.0853618091418538 0.25840481142415 PLSCR1/NDRG1 2 GO:0046824 positive regulation of nucleocytoplasmic transport 2/147 62/18722 0.0853618091418538 0.25840481142415 SHH/SMAD3 2 GO:0045667 regulation of osteoblast differentiation 3/147 132/18722 0.0857419010302206 0.25840481142415 TOB1/SMAD3/CEBPB 3 GO:0006469 negative regulation of protein kinase activity 4/147 212/18722 0.0860815463299787 0.25840481142415 DEPTOR/SNCA/SH3BP5/HEXIM1 4 GO:0001505 regulation of neurotransmitter levels 4/147 213/18722 0.087221286609435 0.25840481142415 SNCA/SLC30A1/DNAJC5/ALDH5A1 4 GO:0051651 maintenance of location in cell 4/147 213/18722 0.087221286609435 0.25840481142415 SNCA/VPS13A/CHERP/GJA1 4 GO:0010565 regulation of cellular ketone metabolic process 3/147 133/18722 0.0872393578428616 0.25840481142415 PPARGC1A/SNCA/IRS2 3 GO:0010595 positive regulation of endothelial cell migration 3/147 133/18722 0.0872393578428616 0.25840481142415 ATOH8/VEGFA/HIF1A 3 GO:0046887 positive regulation of hormone secretion 3/147 133/18722 0.0872393578428616 0.25840481142415 IRS2/GJA1/HIF1A 3 GO:0016239 positive regulation of macroautophagy 2/147 63/18722 0.0877225598288564 0.25840481142415 PRKAA2/HIF1A 2 GO:0046902 regulation of mitochondrial membrane permeability 2/147 63/18722 0.0877225598288564 0.25840481142415 HSPA1A/GCLC 2 GO:1904589 regulation of protein import 2/147 63/18722 0.0877225598288564 0.25840481142415 SHH/SMAD3 2 GO:2000242 negative regulation of reproductive process 2/147 63/18722 0.0877225598288564 0.25840481142415 GJA1/PLAT 2 GO:0061041 regulation of wound healing 3/147 134/18722 0.0887478994169102 0.25840481142415 GJA1/PLAT/SMAD3 3 GO:0006913 nucleocytoplasmic transport 5/147 301/18722 0.0889111455422272 0.25840481142415 SHH/CCHCR1/ALKBH5/RBM15B/SMAD3 5 GO:0042886 amide transport 5/147 301/18722 0.0889111455422272 0.25840481142415 SLC15A4/SLC15A1/IRS2/GJA1/HIF1A 5 GO:0051169 nuclear transport 5/147 301/18722 0.0889111455422272 0.25840481142415 SHH/CCHCR1/ALKBH5/RBM15B/SMAD3 5 GO:0042110 T cell activation 7/147 487/18722 0.0895914530685199 0.25840481142415 SOCS1/SHH/CBFB/PKNOX1/CD55/SMAD3/CEBPB 7 GO:0032507 maintenance of protein location in cell 2/147 64/18722 0.0901027457356897 0.25840481142415 VPS13A/GJA1 2 GO:0045670 regulation of osteoclast differentiation 2/147 64/18722 0.0901027457356897 0.25840481142415 FOS/CEBPB 2 GO:0046854 phosphatidylinositol phosphate biosynthetic process 2/147 64/18722 0.0901027457356897 0.25840481142415 SOCS1/SOCS3 2 GO:0070542 response to fatty acid 2/147 64/18722 0.0901027457356897 0.25840481142415 PPARGC1A/ALAD 2 GO:1900076 regulation of cellular response to insulin stimulus 2/147 64/18722 0.0901027457356897 0.25840481142415 SOCS1/SOCS3 2 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 2/147 64/18722 0.0901027457356897 0.25840481142415 SHH/ALAD 2 GO:1903409 reactive oxygen species biosynthetic process 2/147 64/18722 0.0901027457356897 0.25840481142415 SNCA/SOD2 2 GO:0000491 small nucleolar ribonucleoprotein complex assembly 1/147 12/18722 0.0902818548773776 0.25840481142415 PIH1D1 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/147 12/18722 0.0902818548773776 0.25840481142415 SOD2 1 GO:0002903 negative regulation of B cell apoptotic process 1/147 12/18722 0.0902818548773776 0.25840481142415 IRS2 1 GO:0003306 Wnt signaling pathway involved in heart development 1/147 12/18722 0.0902818548773776 0.25840481142415 DKK1 1 GO:0006534 cysteine metabolic process 1/147 12/18722 0.0902818548773776 0.25840481142415 GCLC 1 GO:0007501 mesodermal cell fate specification 1/147 12/18722 0.0902818548773776 0.25840481142415 DKK1 1 GO:0008228 opsonization 1/147 12/18722 0.0902818548773776 0.25840481142415 C4BPA 1 GO:0009086 methionine biosynthetic process 1/147 12/18722 0.0902818548773776 0.25840481142415 MTAP 1 GO:0010454 negative regulation of cell fate commitment 1/147 12/18722 0.0902818548773776 0.25840481142415 DKK1 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0014889 muscle atrophy 1/147 12/18722 0.0902818548773776 0.25840481142415 PPARGC1A 1 GO:0021670 lateral ventricle development 1/147 12/18722 0.0902818548773776 0.25840481142415 TSKU 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0021978 telencephalon regionalization 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0030238 male sex determination 1/147 12/18722 0.0902818548773776 0.25840481142415 MAP3K4 1 GO:0032908 regulation of transforming growth factor beta1 production 1/147 12/18722 0.0902818548773776 0.25840481142415 TSKU 1 GO:0033079 immature T cell proliferation 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0034154 toll-like receptor 7 signaling pathway 1/147 12/18722 0.0902818548773776 0.25840481142415 SLC15A4 1 GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/147 12/18722 0.0902818548773776 0.25840481142415 CD55 1 GO:0038203 TORC2 signaling 1/147 12/18722 0.0902818548773776 0.25840481142415 DEPTOR 1 GO:0042762 regulation of sulfur metabolic process 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0043248 proteasome assembly 1/147 12/18722 0.0902818548773776 0.25840481142415 PSMG1 1 GO:0043301 negative regulation of leukocyte degranulation 1/147 12/18722 0.0902818548773776 0.25840481142415 HLA-F 1 GO:0043383 negative T cell selection 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/147 12/18722 0.0902818548773776 0.25840481142415 IGFBP4 1 GO:0045602 negative regulation of endothelial cell differentiation 1/147 12/18722 0.0902818548773776 0.25840481142415 VEGFA 1 GO:0051095 regulation of helicase activity 1/147 12/18722 0.0902818548773776 0.25840481142415 IFIT1 1 GO:0051583 dopamine uptake involved in synaptic transmission 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0051934 catecholamine uptake involved in synaptic transmission 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0060442 branching involved in prostate gland morphogenesis 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0060601 lateral sprouting from an epithelium 1/147 12/18722 0.0902818548773776 0.25840481142415 SHH 1 GO:0070493 thrombin-activated receptor signaling pathway 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/147 12/18722 0.0902818548773776 0.25840481142415 CCNH 1 GO:0071107 response to parathyroid hormone 1/147 12/18722 0.0902818548773776 0.25840481142415 GJA1 1 GO:0071635 negative regulation of transforming growth factor beta production 1/147 12/18722 0.0902818548773776 0.25840481142415 TSKU 1 GO:0071872 cellular response to epinephrine stimulus 1/147 12/18722 0.0902818548773776 0.25840481142415 SNCA 1 GO:0072537 fibroblast activation 1/147 12/18722 0.0902818548773776 0.25840481142415 GCLC 1 GO:0072584 caveolin-mediated endocytosis 1/147 12/18722 0.0902818548773776 0.25840481142415 PACSIN2 1 GO:0090677 reversible differentiation 1/147 12/18722 0.0902818548773776 0.25840481142415 SOD2 1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/147 12/18722 0.0902818548773776 0.25840481142415 HSPA1A 1 GO:0140289 protein mono-ADP-ribosylation 1/147 12/18722 0.0902818548773776 0.25840481142415 PARP9 1 GO:0150065 regulation of deacetylase activity 1/147 12/18722 0.0902818548773776 0.25840481142415 VEGFA 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/147 12/18722 0.0902818548773776 0.25840481142415 HIF1A 1 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/147 12/18722 0.0902818548773776 0.25840481142415 CD55 1 GO:0050870 positive regulation of T cell activation 4/147 216/18722 0.0906844900808595 0.259309091617448 SOCS1/SHH/CBFB/CD55 4 GO:0003158 endothelium development 3/147 136/18722 0.0917978694146106 0.261537062290137 ATOH8/VEGFA/GJA1 3 GO:0043401 steroid hormone mediated signaling pathway 3/147 136/18722 0.0917978694146106 0.261537062290137 PMEPA1/PIAS2/DAB2 3 GO:1900180 regulation of protein localization to nucleus 3/147 136/18722 0.0917978694146106 0.261537062290137 SHH/PARP9/SMAD3 3 GO:0010498 proteasomal protein catabolic process 7/147 490/18722 0.0918134120376609 0.261537062290137 SHH/HSPA1A/PSMC4/ALAD/HSPA1B/GCLC/DAB2 7 GO:0002720 positive regulation of cytokine production involved in immune response 2/147 65/18722 0.0925019212273425 0.262747622403591 HLA-F/CD55 2 GO:0048645 animal organ formation 2/147 65/18722 0.0925019212273425 0.262747622403591 SHH/DKK1 2 GO:0090307 mitotic spindle assembly 2/147 65/18722 0.0925019212273425 0.262747622403591 HSPA1A/HSPA1B 2 GO:0006986 response to unfolded protein 3/147 137/18722 0.0933391126734212 0.264122314102368 HSPA1A/PPP1R15A/HSPA1B 3 GO:0050671 positive regulation of lymphocyte proliferation 3/147 137/18722 0.0933391126734212 0.264122314102368 SHH/IRS2/CD55 3 GO:0050714 positive regulation of protein secretion 3/147 137/18722 0.0933391126734212 0.264122314102368 IRS2/GJA1/HIF1A 3 GO:0055123 digestive system development 3/147 137/18722 0.0933391126734212 0.264122314102368 SHH/SMAD3/HIF1A 3 GO:0032946 positive regulation of mononuclear cell proliferation 3/147 138/18722 0.0948910704132133 0.265401653344621 SHH/IRS2/CD55 3 GO:0019229 regulation of vasoconstriction 2/147 66/18722 0.0949196463821067 0.265401653344621 BDKRB2/GJA1 2 GO:0042446 hormone biosynthetic process 2/147 66/18722 0.0949196463821067 0.265401653344621 PPARGC1A/HIF1A 2 GO:0045600 positive regulation of fat cell differentiation 2/147 66/18722 0.0949196463821067 0.265401653344621 STK4/CEBPB 2 GO:0046626 regulation of insulin receptor signaling pathway 2/147 66/18722 0.0949196463821067 0.265401653344621 SOCS1/SOCS3 2 GO:0050918 positive chemotaxis 2/147 66/18722 0.0949196463821067 0.265401653344621 VEGFA/SMAD3 2 GO:0051893 regulation of focal adhesion assembly 2/147 66/18722 0.0949196463821067 0.265401653344621 VEGFA/SMAD3 2 GO:0090109 regulation of cell-substrate junction assembly 2/147 66/18722 0.0949196463821067 0.265401653344621 VEGFA/SMAD3 2 GO:1905953 negative regulation of lipid localization 2/147 66/18722 0.0949196463821067 0.265401653344621 SHH/IRS2 2 GO:2000272 negative regulation of signaling receptor activity 2/147 66/18722 0.0949196463821067 0.265401653344621 PPARGC1A/DKK1 2 GO:2000573 positive regulation of DNA biosynthetic process 2/147 66/18722 0.0949196463821067 0.265401653344621 MAP3K4/MYC 2 GO:0002064 epithelial cell development 4/147 220/18722 0.0954035663511935 0.265401653344621 B4GALT1/TFCP2L1/VEGFA/HIF1A 4 GO:0048705 skeletal system morphogenesis 4/147 220/18722 0.0954035663511935 0.265401653344621 TSKU/SMAD3/HOXD8/DLX5 4 GO:0010810 regulation of cell-substrate adhesion 4/147 221/18722 0.0966012426489382 0.265401653344621 STK4/VEGFA/SPOCK1/SMAD3 4 GO:0032890 regulation of organic acid transport 2/147 67/18722 0.0973554869303563 0.265401653344621 SNCA/IRS2 2 GO:0035914 skeletal muscle cell differentiation 2/147 67/18722 0.0973554869303563 0.265401653344621 FOS/MAFF 2 GO:0042130 negative regulation of T cell proliferation 2/147 67/18722 0.0973554869303563 0.265401653344621 SHH/CEBPB 2 GO:0061180 mammary gland epithelium development 2/147 67/18722 0.0973554869303563 0.265401653344621 HIF1A/CEBPB 2 GO:0001778 plasma membrane repair 1/147 13/18722 0.0974292930031406 0.265401653344621 MYOF 1 GO:0002551 mast cell chemotaxis 1/147 13/18722 0.0974292930031406 0.265401653344621 VEGFA 1 GO:0006361 transcription initiation from RNA polymerase I promoter 1/147 13/18722 0.0974292930031406 0.265401653344621 PIH1D1 1 GO:0014745 negative regulation of muscle adaptation 1/147 13/18722 0.0974292930031406 0.265401653344621 SMAD3 1 GO:0021794 thalamus development 1/147 13/18722 0.0974292930031406 0.265401653344621 SHH 1 GO:0031053 primary miRNA processing 1/147 13/18722 0.0974292930031406 0.265401653344621 SMAD3 1 GO:0032042 mitochondrial DNA metabolic process 1/147 13/18722 0.0974292930031406 0.265401653344621 PPARGC1A 1 GO:0032905 transforming growth factor beta1 production 1/147 13/18722 0.0974292930031406 0.265401653344621 TSKU 1 GO:0033689 negative regulation of osteoblast proliferation 1/147 13/18722 0.0974292930031406 0.265401653344621 SMAD3 1 GO:0042659 regulation of cell fate specification 1/147 13/18722 0.0974292930031406 0.265401653344621 DKK1 1 GO:0043201 response to leucine 1/147 13/18722 0.0974292930031406 0.265401653344621 PPARGC1A 1 GO:0043970 histone H3-K9 acetylation 1/147 13/18722 0.0974292930031406 0.265401653344621 PIH1D1 1 GO:0046689 response to mercury ion 1/147 13/18722 0.0974292930031406 0.265401653344621 ALAD 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/147 13/18722 0.0974292930031406 0.265401653344621 SLC15A4 1 GO:0051481 negative regulation of cytosolic calcium ion concentration 1/147 13/18722 0.0974292930031406 0.265401653344621 SMAD3 1 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/147 13/18722 0.0974292930031406 0.265401653344621 TOB1 1 GO:0060670 branching involved in labyrinthine layer morphogenesis 1/147 13/18722 0.0974292930031406 0.265401653344621 SOCS3 1 GO:0060707 trophoblast giant cell differentiation 1/147 13/18722 0.0974292930031406 0.265401653344621 SOCS3 1 GO:0090042 tubulin deacetylation 1/147 13/18722 0.0974292930031406 0.265401653344621 PRKAA2 1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/147 13/18722 0.0974292930031406 0.265401653344621 STK4 1 GO:1902947 regulation of tau-protein kinase activity 1/147 13/18722 0.0974292930031406 0.265401653344621 DKK1 1 GO:1903651 positive regulation of cytoplasmic transport 1/147 13/18722 0.0974292930031406 0.265401653344621 DAB2 1 GO:2001198 regulation of dendritic cell differentiation 1/147 13/18722 0.0974292930031406 0.265401653344621 CEBPB 1 GO:0051047 positive regulation of secretion 5/147 310/18722 0.0977056721929161 0.265701902113571 SNCA/HLA-F/IRS2/GJA1/HIF1A 5 GO:0000302 response to reactive oxygen species 4/147 222/18722 0.0978060161240526 0.265701902113571 PPARGC1A/FOS/SOD2/HIF1A 4 GO:0015931 nucleobase-containing compound transport 4/147 222/18722 0.0978060161240526 0.265701902113571 SLC35B2/GJA1/ALKBH5/RBM15B 4 GO:0031333 negative regulation of protein-containing complex assembly 3/147 140/18722 0.098026753164186 0.266059908089002 SNCA/PMEPA1/DKK1 3 GO:0034341 response to interferon-gamma 3/147 141/18722 0.099610288882495 0.269430290120964 SOCS1/SNCA/PARP9 3 GO:0050921 positive regulation of chemotaxis 3/147 141/18722 0.099610288882495 0.269430290120964 TPBG/VEGFA/SMAD3 3 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 2/147 68/18722 0.0998090141939243 0.269430290120964 PPARGC1A/AK4 2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 2/147 68/18722 0.0998090141939243 0.269430290120964 GH2/PARP9 2 GO:0051148 negative regulation of muscle cell differentiation 2/147 68/18722 0.0998090141939243 0.269430290120964 SHH/DKK1 2 GO:0051926 negative regulation of calcium ion transport 2/147 68/18722 0.0998090141939243 0.269430290120964 GEM/SLC30A1 2 GO:0072006 nephron development 3/147 142/18722 0.101204160541997 0.26950187478193 SHH/VEGFA/MYC 3 GO:0050670 regulation of lymphocyte proliferation 4/147 225/18722 0.101462581886037 0.26950187478193 SHH/IRS2/CD55/CEBPB 4 GO:0060249 anatomical structure homeostasis 5/147 314/18722 0.101751474513457 0.26950187478193 IGKC/CTSH/VEGFA/GJA1/HIF1A 5 GO:0006368 transcription elongation from RNA polymerase II promoter 2/147 69/18722 0.102279805026072 0.26950187478193 SHH/HEXIM1 2 GO:0009145 purine nucleoside triphosphate biosynthetic process 2/147 69/18722 0.102279805026072 0.26950187478193 PPARGC1A/AK4 2 GO:0015807 L-amino acid transport 2/147 69/18722 0.102279805026072 0.26950187478193 SLC7A2/SLC25A29 2 GO:0031060 regulation of histone methylation 2/147 69/18722 0.102279805026072 0.26950187478193 NNMT/PIH1D1 2 GO:0033344 cholesterol efflux 2/147 69/18722 0.102279805026072 0.26950187478193 SHH/TSKU 2 GO:0034605 cellular response to heat 2/147 69/18722 0.102279805026072 0.26950187478193 HSPA1A/HSPA1B 2 GO:0050688 regulation of defense response to virus 2/147 69/18722 0.102279805026072 0.26950187478193 IFIT1/PARP9 2 GO:0050805 negative regulation of synaptic transmission 2/147 69/18722 0.102279805026072 0.26950187478193 ATAD1/SLC30A1 2 GO:0002703 regulation of leukocyte mediated immunity 4/147 226/18722 0.102695404375093 0.26950187478193 SLC15A4/HLA-F/CD55/C4BPA 4 GO:0034763 negative regulation of transmembrane transport 3/147 143/18722 0.102808272391862 0.26950187478193 GEM/SLC30A1/IRS2 3 GO:0007411 axon guidance 4/147 227/18722 0.103935152248833 0.26950187478193 SHH/TRIO/VEGFA/DLX5 4 GO:0032944 regulation of mononuclear cell proliferation 4/147 227/18722 0.103935152248833 0.26950187478193 SHH/IRS2/CD55/CEBPB 4 GO:0001711 endodermal cell fate commitment 1/147 14/18722 0.104520954445683 0.26950187478193 DKK1 1 GO:0001921 positive regulation of receptor recycling 1/147 14/18722 0.104520954445683 0.26950187478193 SNCA 1 GO:0002475 antigen processing and presentation via MHC class Ib 1/147 14/18722 0.104520954445683 0.26950187478193 HLA-F 1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 1/147 14/18722 0.104520954445683 0.26950187478193 TSKU 1 GO:0006596 polyamine biosynthetic process 1/147 14/18722 0.104520954445683 0.26950187478193 NNMT 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:0015812 gamma-aminobutyric acid transport 1/147 14/18722 0.104520954445683 0.26950187478193 TRPC4 1 GO:0022038 corpus callosum development 1/147 14/18722 0.104520954445683 0.26950187478193 TSKU 1 GO:0031115 negative regulation of microtubule polymerization 1/147 14/18722 0.104520954445683 0.26950187478193 SNCA 1 GO:0033212 iron import into cell 1/147 14/18722 0.104520954445683 0.26950187478193 SLC39A14 1 GO:0035437 maintenance of protein localization in endoplasmic reticulum 1/147 14/18722 0.104520954445683 0.26950187478193 GJA1 1 GO:0035563 positive regulation of chromatin binding 1/147 14/18722 0.104520954445683 0.26950187478193 PARP9 1 GO:0043558 regulation of translational initiation in response to stress 1/147 14/18722 0.104520954445683 0.26950187478193 PPP1R15A 1 GO:0045059 positive thymic T cell selection 1/147 14/18722 0.104520954445683 0.26950187478193 SHH 1 GO:0045472 response to ether 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:0045820 negative regulation of glycolytic process 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:0047484 regulation of response to osmotic stress 1/147 14/18722 0.104520954445683 0.26950187478193 BDKRB2 1 GO:0048148 behavioral response to cocaine 1/147 14/18722 0.104520954445683 0.26950187478193 SNCA 1 GO:0048291 isotype switching to IgG isotypes 1/147 14/18722 0.104520954445683 0.26950187478193 SLC15A4 1 GO:0048368 lateral mesoderm development 1/147 14/18722 0.104520954445683 0.26950187478193 SHH 1 GO:0050930 induction of positive chemotaxis 1/147 14/18722 0.104520954445683 0.26950187478193 VEGFA 1 GO:0060081 membrane hyperpolarization 1/147 14/18722 0.104520954445683 0.26950187478193 SOD2 1 GO:0060576 intestinal epithelial cell development 1/147 14/18722 0.104520954445683 0.26950187478193 HIF1A 1 GO:0060732 positive regulation of inositol phosphate biosynthetic process 1/147 14/18722 0.104520954445683 0.26950187478193 SNCA 1 GO:0060841 venous blood vessel development 1/147 14/18722 0.104520954445683 0.26950187478193 VEGFA 1 GO:0060911 cardiac cell fate commitment 1/147 14/18722 0.104520954445683 0.26950187478193 DKK1 1 GO:0071285 cellular response to lithium ion 1/147 14/18722 0.104520954445683 0.26950187478193 SHH 1 GO:0071415 cellular response to purine-containing compound 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:0090239 regulation of histone H4 acetylation 1/147 14/18722 0.104520954445683 0.26950187478193 PIH1D1 1 GO:0090281 negative regulation of calcium ion import 1/147 14/18722 0.104520954445683 0.26950187478193 SLC30A1 1 GO:0097531 mast cell migration 1/147 14/18722 0.104520954445683 0.26950187478193 VEGFA 1 GO:1901722 regulation of cell proliferation involved in kidney development 1/147 14/18722 0.104520954445683 0.26950187478193 MYC 1 GO:1901857 positive regulation of cellular respiration 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/147 14/18722 0.104520954445683 0.26950187478193 YTHDF2 1 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 1/147 14/18722 0.104520954445683 0.26950187478193 SOD2 1 GO:1905208 negative regulation of cardiocyte differentiation 1/147 14/18722 0.104520954445683 0.26950187478193 DKK1 1 GO:2001171 positive regulation of ATP biosynthetic process 1/147 14/18722 0.104520954445683 0.26950187478193 PPARGC1A 1 GO:0006959 humoral immune response 5/147 317/18722 0.10484035125352 0.270092584495503 CFI/IGKC/CD55/C4BPA/YTHDF2 5 GO:0097485 neuron projection guidance 4/147 228/18722 0.105181790004743 0.270739013686907 SHH/TRIO/VEGFA/DLX5 4 GO:0007269 neurotransmitter secretion 3/147 145/18722 0.106046831672043 0.272496626744915 SNCA/SLC30A1/DNAJC5 3 GO:0099643 signal release from synapse 3/147 145/18722 0.106046831672043 0.272496626744915 SNCA/SLC30A1/DNAJC5 3 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6/147 412/18722 0.106319206319671 0.272962013821577 SHH/HSPA1A/PSMC4/HSPA1B/GCLC/DAB2 6 GO:0007204 positive regulation of cytosolic calcium ion concentration 5/147 319/18722 0.106925321810523 0.27428270800624 BDKRB2/SNCA/CHERP/GJA1/CD55 5 GO:0045824 negative regulation of innate immune response 2/147 71/18722 0.107271512110232 0.27469956568639 HLA-F/YTHDF2 2 GO:0150116 regulation of cell-substrate junction organization 2/147 71/18722 0.107271512110232 0.27469956568639 VEGFA/SMAD3 2 GO:0045580 regulation of T cell differentiation 3/147 146/18722 0.107681085677806 0.275314114243831 SOCS1/SHH/CBFB 3 GO:0045333 cellular respiration 4/147 230/18722 0.107695591329081 0.275314114243831 PPARGC1A/SNCA/AK4/HIF1A 4 GO:0001889 liver development 3/147 147/18722 0.109325193066893 0.27644390977263 AK4/SMAD3/CEBPB 3 GO:0016331 morphogenesis of embryonic epithelium 3/147 147/18722 0.109325193066893 0.27644390977263 SHH/STK4/HIF1A 3 GO:1902850 microtubule cytoskeleton organization involved in mitosis 3/147 147/18722 0.109325193066893 0.27644390977263 HSPA1A/GJA1/HSPA1B 3 GO:0001736 establishment of planar polarity 2/147 72/18722 0.109791609193839 0.27644390977263 DAB2/DKK1 2 GO:0007164 establishment of tissue polarity 2/147 72/18722 0.109791609193839 0.27644390977263 DAB2/DKK1 2 GO:0070227 lymphocyte apoptotic process 2/147 72/18722 0.109791609193839 0.27644390977263 IRS2/HIF1A 2 GO:1903900 regulation of viral life cycle 3/147 148/18722 0.110979056291797 0.27644390977263 MX1/PLSCR1/IFIT1 3 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/147 15/18722 0.111557271513061 0.27644390977263 NOP14 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/147 15/18722 0.111557271513061 0.27644390977263 NOP14 1 GO:0006089 lactate metabolic process 1/147 15/18722 0.111557271513061 0.27644390977263 HIF1A 1 GO:0009163 nucleoside biosynthetic process 1/147 15/18722 0.111557271513061 0.27644390977263 MTAP 1 GO:0010889 regulation of sequestering of triglyceride 1/147 15/18722 0.111557271513061 0.27644390977263 PLIN2 1 GO:0014048 regulation of glutamate secretion 1/147 15/18722 0.111557271513061 0.27644390977263 SNCA 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/147 15/18722 0.111557271513061 0.27644390977263 SHH 1 GO:0015697 quaternary ammonium group transport 1/147 15/18722 0.111557271513061 0.27644390977263 SLC25A29 1 GO:0032897 negative regulation of viral transcription 1/147 15/18722 0.111557271513061 0.27644390977263 HEXIM1 1 GO:0034404 nucleobase-containing small molecule biosynthetic process 1/147 15/18722 0.111557271513061 0.27644390977263 MTAP 1 GO:0035493 SNARE complex assembly 1/147 15/18722 0.111557271513061 0.27644390977263 SNCA 1 GO:0036124 histone H3-K9 trimethylation 1/147 15/18722 0.111557271513061 0.27644390977263 PIH1D1 1 GO:0042976 activation of Janus kinase activity 1/147 15/18722 0.111557271513061 0.27644390977263 SOCS1 1 GO:0043584 nose development 1/147 15/18722 0.111557271513061 0.27644390977263 DLX5 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/147 15/18722 0.111557271513061 0.27644390977263 IRS2 1 GO:0048569 post-embryonic animal organ development 1/147 15/18722 0.111557271513061 0.27644390977263 VEGFA 1 GO:0060046 regulation of acrosome reaction 1/147 15/18722 0.111557271513061 0.27644390977263 B4GALT1 1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 1/147 15/18722 0.111557271513061 0.27644390977263 TOB1 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/147 15/18722 0.111557271513061 0.27644390977263 CHERP 1 GO:0071380 cellular response to prostaglandin E stimulus 1/147 15/18722 0.111557271513061 0.27644390977263 PRKAA2 1 GO:0072044 collecting duct development 1/147 15/18722 0.111557271513061 0.27644390977263 SHH 1 GO:0080154 regulation of fertilization 1/147 15/18722 0.111557271513061 0.27644390977263 PLAT 1 GO:0090594 inflammatory response to wounding 1/147 15/18722 0.111557271513061 0.27644390977263 HIF1A 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/147 15/18722 0.111557271513061 0.27644390977263 CHERP 1 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 1/147 15/18722 0.111557271513061 0.27644390977263 PPP1R15A 1 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/147 15/18722 0.111557271513061 0.27644390977263 TOB1 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/147 15/18722 0.111557271513061 0.27644390977263 PIH1D1 1 GO:1901841 regulation of high voltage-gated calcium channel activity 1/147 15/18722 0.111557271513061 0.27644390977263 GEM 1 GO:1905146 lysosomal protein catabolic process 1/147 15/18722 0.111557271513061 0.27644390977263 VPS13A 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/147 15/18722 0.111557271513061 0.27644390977263 VEGFA 1 GO:0007409 axonogenesis 6/147 418/18722 0.111833535400853 0.276899093033072 SHH/TRIO/SLITRK4/VEGFA/TSKU/DLX5 6 GO:0072089 stem cell proliferation 2/147 73/18722 0.112327331393224 0.277891685853707 GJA1/YTHDF2 2 GO:0051592 response to calcium ion 3/147 149/18722 0.112642577507481 0.278441280433781 S100A16/PRKAA2/FOS 3 GO:0032102 negative regulation of response to external stimulus 6/147 420/18722 0.113703787076386 0.280832392357945 HLA-F/GJA1/PLAT/YTHDF2/SMAD3/SOCS3 6 GO:0061008 hepaticobiliary system development 3/147 150/18722 0.11431565859113 0.281409453296581 AK4/SMAD3/CEBPB 3 GO:0070665 positive regulation of leukocyte proliferation 3/147 150/18722 0.11431565859113 0.281409453296581 SHH/IRS2/CD55 3 GO:0051235 maintenance of location 5/147 326/18722 0.114382574990083 0.281409453296581 SNCA/VPS13A/CHERP/PLIN2/GJA1 5 GO:0003151 outflow tract morphogenesis 2/147 74/18722 0.114878282338725 0.281409453296581 VEGFA/HIF1A 2 GO:0006635 fatty acid beta-oxidation 2/147 74/18722 0.114878282338725 0.281409453296581 MCAT/IRS2 2 GO:0009201 ribonucleoside triphosphate biosynthetic process 2/147 74/18722 0.114878282338725 0.281409453296581 PPARGC1A/AK4 2 GO:0010822 positive regulation of mitochondrion organization 2/147 74/18722 0.114878282338725 0.281409453296581 PPARGC1A/HIF1A 2 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 2/147 74/18722 0.114878282338725 0.281409453296581 PIAS2/DAB2 2 GO:0070972 protein localization to endoplasmic reticulum 2/147 74/18722 0.114878282338725 0.281409453296581 PPP1R15A/GJA1 2 GO:1903201 regulation of oxidative stress-induced cell death 2/147 74/18722 0.114878282338725 0.281409453296581 SOD2/HIF1A 2 GO:0046395 carboxylic acid catabolic process 4/147 236/18722 0.115398549681183 0.282284372211808 MCAT/LPIN3/IRS2/ALDH5A1 4 GO:0006816 calcium ion transport 6/147 422/18722 0.115589974555927 0.282284372211808 SNCA/GEM/SLC30A1/CHERP/GJA1/TRPC4 6 GO:0030902 hindbrain development 3/147 151/18722 0.115998201161543 0.282284372211808 PPARGC1A/SHH/PSMG1 3 GO:0048592 eye morphogenesis 3/147 151/18722 0.115998201161543 0.282284372211808 VEGFA/TSKU/HIF1A 3 GO:0048662 negative regulation of smooth muscle cell proliferation 2/147 75/18722 0.117444070844085 0.282284372211808 PPARGC1A/SOD2 2 GO:1903363 negative regulation of cellular protein catabolic process 2/147 75/18722 0.117444070844085 0.282284372211808 SHH/ALAD 2 GO:0050863 regulation of T cell activation 5/147 329/18722 0.117653575368233 0.282284372211808 SOCS1/SHH/CBFB/CD55/CEBPB 5 GO:0016573 histone acetylation 3/147 152/18722 0.117690106598178 0.282284372211808 PPARGC1A/SNCA/PIH1D1 3 GO:0021915 neural tube development 3/147 152/18722 0.117690106598178 0.282284372211808 SHH/STK4/HIF1A 3 GO:0051259 protein complex oligomerization 4/147 238/18722 0.118019047069987 0.282284372211808 SNCA/STK4/ALAD/SOD2 4 GO:0001845 phagolysosome assembly 1/147 16/18722 0.118538673185567 0.282284372211808 SRPX 1 GO:0001977 renal system process involved in regulation of blood volume 1/147 16/18722 0.118538673185567 0.282284372211808 GJA1 1 GO:0006555 methionine metabolic process 1/147 16/18722 0.118538673185567 0.282284372211808 MTAP 1 GO:0006750 glutathione biosynthetic process 1/147 16/18722 0.118538673185567 0.282284372211808 GCLC 1 GO:0007635 chemosensory behavior 1/147 16/18722 0.118538673185567 0.282284372211808 TPBG 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/147 16/18722 0.118538673185567 0.282284372211808 RBM15B 1 GO:0010225 response to UV-C 1/147 16/18722 0.118538673185567 0.282284372211808 MAP3K4 1 GO:0010649 regulation of cell communication by electrical coupling 1/147 16/18722 0.118538673185567 0.282284372211808 GJA1 1 GO:0010919 regulation of inositol phosphate biosynthetic process 1/147 16/18722 0.118538673185567 0.282284372211808 SNCA 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 1/147 16/18722 0.118538673185567 0.282284372211808 HIF1A 1 GO:0032274 gonadotropin secretion 1/147 16/18722 0.118538673185567 0.282284372211808 GJA1 1 GO:0035864 response to potassium ion 1/147 16/18722 0.118538673185567 0.282284372211808 PPARGC1A 1 GO:0042481 regulation of odontogenesis 1/147 16/18722 0.118538673185567 0.282284372211808 SHH 1 GO:0048557 embryonic digestive tract morphogenesis 1/147 16/18722 0.118538673185567 0.282284372211808 SHH 1 GO:0055089 fatty acid homeostasis 1/147 16/18722 0.118538673185567 0.282284372211808 PRKAA2 1 GO:0060572 morphogenesis of an epithelial bud 1/147 16/18722 0.118538673185567 0.282284372211808 SHH 1 GO:0061684 chaperone-mediated autophagy 1/147 16/18722 0.118538673185567 0.282284372211808 SNCA 1 GO:0070242 thymocyte apoptotic process 1/147 16/18722 0.118538673185567 0.282284372211808 HIF1A 1 GO:0071361 cellular response to ethanol 1/147 16/18722 0.118538673185567 0.282284372211808 SOD2 1 GO:0080009 mRNA methylation 1/147 16/18722 0.118538673185567 0.282284372211808 PCIF1 1 GO:0097284 hepatocyte apoptotic process 1/147 16/18722 0.118538673185567 0.282284372211808 STK4 1 GO:1901201 regulation of extracellular matrix assembly 1/147 16/18722 0.118538673185567 0.282284372211808 SMAD3 1 GO:2000232 regulation of rRNA processing 1/147 16/18722 0.118538673185567 0.282284372211808 YTHDF2 1 GO:2000765 regulation of cytoplasmic translation 1/147 16/18722 0.118538673185567 0.282284372211808 PKM 1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 1/147 16/18722 0.118538673185567 0.282284372211808 PARP9 1 GO:0072593 reactive oxygen species metabolic process 4/147 239/18722 0.119339030259409 0.283738505171615 SNCA/HBG1/SOD2/HIF1A 4 GO:1903039 positive regulation of leukocyte cell-cell adhesion 4/147 239/18722 0.119339030259409 0.283738505171615 SOCS1/SHH/CBFB/CD55 4 GO:0001937 negative regulation of endothelial cell proliferation 2/147 76/18722 0.120024310850421 0.284013222906337 ATOH8/GJA1 2 GO:0014855 striated muscle cell proliferation 2/147 76/18722 0.120024310850421 0.284013222906337 SHH/GJA1 2 GO:0031100 animal organ regeneration 2/147 76/18722 0.120024310850421 0.284013222906337 NNMT/CEBPB 2 GO:0043536 positive regulation of blood vessel endothelial cell migration 2/147 76/18722 0.120024310850421 0.284013222906337 VEGFA/HIF1A 2 GO:0071426 ribonucleoprotein complex export from nucleus 2/147 76/18722 0.120024310850421 0.284013222906337 ALKBH5/RBM15B 2 GO:2000379 positive regulation of reactive oxygen species metabolic process 2/147 76/18722 0.120024310850421 0.284013222906337 SNCA/SOD2 2 GO:0016054 organic acid catabolic process 4/147 240/18722 0.120665450578508 0.285079275418892 MCAT/LPIN3/IRS2/ALDH5A1 4 GO:0032886 regulation of microtubule-based process 4/147 240/18722 0.120665450578508 0.285079275418892 SNCA/HSPA1A/PRKAA2/HSPA1B 4 GO:0051168 nuclear export 3/147 154/18722 0.12110161050305 0.285157724283642 CCHCR1/ALKBH5/RBM15B 3 GO:0006367 transcription initiation from RNA polymerase II promoter 2/147 77/18722 0.122618621370747 0.285157724283642 PPARGC1A/CCNH 2 GO:0007492 endoderm development 2/147 77/18722 0.122618621370747 0.285157724283642 SMAD3/DKK1 2 GO:0071166 ribonucleoprotein complex localization 2/147 77/18722 0.122618621370747 0.285157724283642 ALKBH5/RBM15B 2 GO:0007519 skeletal muscle tissue development 3/147 155/18722 0.122821010700042 0.285157724283642 SHH/FOS/MAFF 3 GO:0043543 protein acylation 4/147 243/18722 0.12468293525206 0.285157724283642 PPARGC1A/SNCA/PRKAA2/PIH1D1 4 GO:0009064 glutamine family amino acid metabolic process 2/147 78/18722 0.125226626435039 0.285157724283642 ALDH5A1/GCLC 2 GO:0030500 regulation of bone mineralization 2/147 78/18722 0.125226626435039 0.285157724283642 SMAD3/HIF1A 2 GO:0034637 cellular carbohydrate biosynthetic process 2/147 78/18722 0.125226626435039 0.285157724283642 B4GALT1/IRS2 2 GO:0090559 regulation of membrane permeability 2/147 78/18722 0.125226626435039 0.285157724283642 HSPA1A/GCLC 2 GO:1903037 regulation of leukocyte cell-cell adhesion 5/147 336/18722 0.125457192208716 0.285157724283642 SOCS1/SHH/CBFB/CD55/CEBPB 5 GO:0000097 sulfur amino acid biosynthetic process 1/147 17/18722 0.125465585141181 0.285157724283642 MTAP 1 GO:0001710 mesodermal cell fate commitment 1/147 17/18722 0.125465585141181 0.285157724283642 DKK1 1 GO:0006895 Golgi to endosome transport 1/147 17/18722 0.125465585141181 0.285157724283642 VPS13A 1 GO:0007351 tripartite regional subdivision 1/147 17/18722 0.125465585141181 0.285157724283642 HOXD8 1 GO:0008340 determination of adult lifespan 1/147 17/18722 0.125465585141181 0.285157724283642 TFCP2L1 1 GO:0008595 anterior/posterior axis specification, embryo 1/147 17/18722 0.125465585141181 0.285157724283642 HOXD8 1 GO:0009812 flavonoid metabolic process 1/147 17/18722 0.125465585141181 0.285157724283642 PPARGC1A 1 GO:0010566 regulation of ketone biosynthetic process 1/147 17/18722 0.125465585141181 0.285157724283642 PPARGC1A 1 GO:0010612 regulation of cardiac muscle adaptation 1/147 17/18722 0.125465585141181 0.285157724283642 SMAD3 1 GO:0010831 positive regulation of myotube differentiation 1/147 17/18722 0.125465585141181 0.285157724283642 ATP11A 1 GO:0014856 skeletal muscle cell proliferation 1/147 17/18722 0.125465585141181 0.285157724283642 SHH 1 GO:0015867 ATP transport 1/147 17/18722 0.125465585141181 0.285157724283642 GJA1 1 GO:0016264 gap junction assembly 1/147 17/18722 0.125465585141181 0.285157724283642 GJA1 1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 1/147 17/18722 0.125465585141181 0.285157724283642 HLA-F 1 GO:0021513 spinal cord dorsal/ventral patterning 1/147 17/18722 0.125465585141181 0.285157724283642 SHH 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/147 17/18722 0.125465585141181 0.285157724283642 GCLC 1 GO:0036166 phenotypic switching 1/147 17/18722 0.125465585141181 0.285157724283642 SOD2 1 GO:0042053 regulation of dopamine metabolic process 1/147 17/18722 0.125465585141181 0.285157724283642 SNCA 1 GO:0042069 regulation of catecholamine metabolic process 1/147 17/18722 0.125465585141181 0.285157724283642 SNCA 1 GO:0042448 progesterone metabolic process 1/147 17/18722 0.125465585141181 0.285157724283642 PPARGC1A 1 GO:0043117 positive regulation of vascular permeability 1/147 17/18722 0.125465585141181 0.285157724283642 VEGFA 1 GO:0044539 long-chain fatty acid import into cell 1/147 17/18722 0.125465585141181 0.285157724283642 IRS2 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/147 17/18722 0.125465585141181 0.285157724283642 SOCS1 1 GO:0048339 paraxial mesoderm development 1/147 17/18722 0.125465585141181 0.285157724283642 SMAD3 1 GO:0051580 regulation of neurotransmitter uptake 1/147 17/18722 0.125465585141181 0.285157724283642 SNCA 1 GO:0055064 chloride ion homeostasis 1/147 17/18722 0.125465585141181 0.285157724283642 CA12 1 GO:0055083 monovalent inorganic anion homeostasis 1/147 17/18722 0.125465585141181 0.285157724283642 CA12 1 GO:0060977 coronary vasculature morphogenesis 1/147 17/18722 0.125465585141181 0.285157724283642 VEGFA 1 GO:0061298 retina vasculature development in camera-type eye 1/147 17/18722 0.125465585141181 0.285157724283642 HIF1A 1 GO:0070875 positive regulation of glycogen metabolic process 1/147 17/18722 0.125465585141181 0.285157724283642 IRS2 1 GO:0090036 regulation of protein kinase C signaling 1/147 17/18722 0.125465585141181 0.285157724283642 VEGFA 1 GO:0090494 dopamine uptake 1/147 17/18722 0.125465585141181 0.285157724283642 SNCA 1 GO:0140354 lipid import into cell 1/147 17/18722 0.125465585141181 0.285157724283642 IRS2 1 GO:1901550 regulation of endothelial cell development 1/147 17/18722 0.125465585141181 0.285157724283642 VEGFA 1 GO:1903140 regulation of establishment of endothelial barrier 1/147 17/18722 0.125465585141181 0.285157724283642 VEGFA 1 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 1/147 17/18722 0.125465585141181 0.285157724283642 SMAD3 1 GO:1903830 magnesium ion transmembrane transport 1/147 17/18722 0.125465585141181 0.285157724283642 SLC41A2 1 GO:1904262 negative regulation of TORC1 signaling 1/147 17/18722 0.125465585141181 0.285157724283642 DEPTOR 1 GO:1904355 positive regulation of telomere capping 1/147 17/18722 0.125465585141181 0.285157724283642 MAP3K4 1 GO:0007034 vacuolar transport 3/147 157/18722 0.126286610628728 0.286588203634694 SLC15A4/HSPA1A/VPS13A 3 GO:2000377 regulation of reactive oxygen species metabolic process 3/147 157/18722 0.126286610628728 0.286588203634694 SNCA/SOD2/HIF1A 3 GO:0070663 regulation of leukocyte proliferation 4/147 245/18722 0.127392707535125 0.288879141954176 SHH/IRS2/CD55/CEBPB 4 GO:0006446 regulation of translational initiation 2/147 79/18722 0.127847955035849 0.289133852063113 PPP1R15A/YTHDF2 2 GO:0018393 internal peptidyl-lysine acetylation 3/147 158/18722 0.128032611141043 0.289133852063113 PPARGC1A/SNCA/PIH1D1 3 GO:0043488 regulation of mRNA stability 3/147 158/18722 0.128032611141043 0.289133852063113 ALKBH5/TOB1/YTHDF2 3 GO:0048545 response to steroid hormone 5/147 339/18722 0.128873694268872 0.289133852063113 ALAD/FOS/PMEPA1/PIAS2/DAB2 5 GO:0007389 pattern specification process 6/147 436/18722 0.129232089048469 0.289133852063113 SHH/SMAD3/BICC1/HOXD8/HIF1A/DKK1 6 GO:0035966 response to topologically incorrect protein 3/147 159/18722 0.12978727900213 0.289133852063113 HSPA1A/PPP1R15A/HSPA1B 3 GO:0001570 vasculogenesis 2/147 80/18722 0.130482241074442 0.289133852063113 SHH/VEGFA 2 GO:0009791 post-embryonic development 2/147 80/18722 0.130482241074442 0.289133852063113 VEGFA/ALDH5A1 2 GO:0032204 regulation of telomere maintenance 2/147 80/18722 0.130482241074442 0.289133852063113 MAP3K4/MYC 2 GO:0021537 telencephalon development 4/147 248/18722 0.131503719875806 0.289133852063113 SHH/TSKU/DLX5/HIF1A 4 GO:0033002 muscle cell proliferation 4/147 248/18722 0.131503719875806 0.289133852063113 PPARGC1A/SHH/GJA1/SOD2 4 GO:0006475 internal protein amino acid acetylation 3/147 160/18722 0.13155051432162 0.289133852063113 PPARGC1A/SNCA/PIH1D1 3 GO:0043271 negative regulation of ion transport 3/147 160/18722 0.13155051432162 0.289133852063113 SNCA/GEM/SLC30A1 3 GO:0090316 positive regulation of intracellular protein transport 3/147 160/18722 0.13155051432162 0.289133852063113 SHH/ZFAND1/SMAD3 3 GO:0001956 positive regulation of neurotransmitter secretion 1/147 18/18722 0.132338429780809 0.289133852063113 SNCA 1 GO:0002544 chronic inflammatory response 1/147 18/18722 0.132338429780809 0.289133852063113 GJA1 1 GO:0003128 heart field specification 1/147 18/18722 0.132338429780809 0.289133852063113 DKK1 1 GO:0003417 growth plate cartilage development 1/147 18/18722 0.132338429780809 0.289133852063113 TSKU 1 GO:0006595 polyamine metabolic process 1/147 18/18722 0.132338429780809 0.289133852063113 NNMT 1 GO:0007549 dosage compensation 1/147 18/18722 0.132338429780809 0.289133852063113 RBM15B 1 GO:0015693 magnesium ion transport 1/147 18/18722 0.132338429780809 0.289133852063113 SLC41A2 1 GO:0019184 nonribosomal peptide biosynthetic process 1/147 18/18722 0.132338429780809 0.289133852063113 GCLC 1 GO:0019896 axonal transport of mitochondrion 1/147 18/18722 0.132338429780809 0.289133852063113 HIF1A 1 GO:0021511 spinal cord patterning 1/147 18/18722 0.132338429780809 0.289133852063113 SHH 1 GO:0030730 sequestering of triglyceride 1/147 18/18722 0.132338429780809 0.289133852063113 PLIN2 1 GO:0031000 response to caffeine 1/147 18/18722 0.132338429780809 0.289133852063113 PPARGC1A 1 GO:0032769 negative regulation of monooxygenase activity 1/147 18/18722 0.132338429780809 0.289133852063113 SNCA 1 GO:0034162 toll-like receptor 9 signaling pathway 1/147 18/18722 0.132338429780809 0.289133852063113 SLC15A4 1 GO:0034587 piRNA metabolic process 1/147 18/18722 0.132338429780809 0.289133852063113 MOV10L1 1 GO:0036499 PERK-mediated unfolded protein response 1/147 18/18722 0.132338429780809 0.289133852063113 PPP1R15A 1 GO:0042693 muscle cell fate commitment 1/147 18/18722 0.132338429780809 0.289133852063113 DKK1 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/147 18/18722 0.132338429780809 0.289133852063113 PIH1D1 1 GO:0043116 negative regulation of vascular permeability 1/147 18/18722 0.132338429780809 0.289133852063113 VEGFA 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/147 18/18722 0.132338429780809 0.289133852063113 HLA-F 1 GO:0048643 positive regulation of skeletal muscle tissue development 1/147 18/18722 0.132338429780809 0.289133852063113 SHH 1 GO:0050665 hydrogen peroxide biosynthetic process 1/147 18/18722 0.132338429780809 0.289133852063113 SOD2 1 GO:0051782 negative regulation of cell division 1/147 18/18722 0.132338429780809 0.289133852063113 MYC 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/147 18/18722 0.132338429780809 0.289133852063113 DAB2 1 GO:0060438 trachea development 1/147 18/18722 0.132338429780809 0.289133852063113 SHH 1 GO:0060602 branch elongation of an epithelium 1/147 18/18722 0.132338429780809 0.289133852063113 SHH 1 GO:0071360 cellular response to exogenous dsRNA 1/147 18/18722 0.132338429780809 0.289133852063113 IFIT1 1 GO:0072189 ureter development 1/147 18/18722 0.132338429780809 0.289133852063113 SHH 1 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 1/147 18/18722 0.132338429780809 0.289133852063113 VEGFA 1 GO:0090493 catecholamine uptake 1/147 18/18722 0.132338429780809 0.289133852063113 SNCA 1 GO:0097709 connective tissue replacement 1/147 18/18722 0.132338429780809 0.289133852063113 HIF1A 1 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/147 18/18722 0.132338429780809 0.289133852063113 TOB1 1 GO:1902001 fatty acid transmembrane transport 1/147 18/18722 0.132338429780809 0.289133852063113 IRS2 1 GO:1902170 cellular response to reactive nitrogen species 1/147 18/18722 0.132338429780809 0.289133852063113 PPARGC1A 1 GO:1905820 positive regulation of chromosome separation 1/147 18/18722 0.132338429780809 0.289133852063113 PLSCR1 1 GO:2000641 regulation of early endosome to late endosome transport 1/147 18/18722 0.132338429780809 0.289133852063113 DAB2 1 GO:0000422 autophagy of mitochondrion 2/147 81/18722 0.133129123307475 0.289592151136479 PPARGC1A/HIF1A 2 GO:0014032 neural crest cell development 2/147 81/18722 0.133129123307475 0.289592151136479 SHH/HIF1A 2 GO:0061726 mitochondrion disassembly 2/147 81/18722 0.133129123307475 0.289592151136479 PPARGC1A/HIF1A 2 GO:0071260 cellular response to mechanical stimulus 2/147 81/18722 0.133129123307475 0.289592151136479 GJA1/GCLC 2 GO:2000106 regulation of leukocyte apoptotic process 2/147 81/18722 0.133129123307475 0.289592151136479 IRS2/HIF1A 2 GO:2000243 positive regulation of reproductive process 2/147 81/18722 0.133129123307475 0.289592151136479 SHH/VEGFA 2 GO:0051090 regulation of DNA-binding transcription factor activity 6/147 440/18722 0.133268052029432 0.289683679956417 PPARGC1A/SHH/HSPA1A/VEGFA/HSPA1B/SMAD3 6 GO:0021953 central nervous system neuron differentiation 3/147 162/18722 0.135102287375118 0.293244514904919 SHH/TSKU/SPOCK1 3 GO:0051100 negative regulation of binding 3/147 162/18722 0.135102287375118 0.293244514904919 IFIT1/DAB2/DKK1 3 GO:0009205 purine ribonucleoside triphosphate metabolic process 2/147 82/18722 0.135788245294196 0.293526417576686 PPARGC1A/AK4 2 GO:1905897 regulation of response to endoplasmic reticulum stress 2/147 82/18722 0.135788245294196 0.293526417576686 HSPA1A/PPP1R15A 2 GO:0022411 cellular component disassembly 6/147 443/18722 0.136334414449997 0.293526417576686 PPARGC1A/ZFAND1/WDR72/MYC/HIF1A/DKK1 6 GO:0051960 regulation of nervous system development 6/147 443/18722 0.136334414449997 0.293526417576686 SHH/SLITRK4/TPBG/VEGFA/YTHDF2/HIF1A 6 GO:0061025 membrane fusion 3/147 163/18722 0.136890624976218 0.293526417576686 SNCA/MYOF/SAMD9 3 GO:0072331 signal transduction by p53 class mediator 3/147 163/18722 0.136890624976218 0.293526417576686 BDKRB2/HEXIM1/NDRG1 3 GO:0045017 glycerolipid biosynthetic process 4/147 252/18722 0.137069843729378 0.293526417576686 SOCS1/PLSCR1/LPIN3/SOCS3 4 GO:0001510 RNA methylation 2/147 83/18722 0.138459255344162 0.293526417576686 PCIF1/RBM15B 2 GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/147 83/18722 0.138459255344162 0.293526417576686 SOCS1/CBFB 2 GO:0050672 negative regulation of lymphocyte proliferation 2/147 83/18722 0.138459255344162 0.293526417576686 SHH/CEBPB 2 GO:0061053 somite development 2/147 83/18722 0.138459255344162 0.293526417576686 SHH/SMAD3 2 GO:0097305 response to alcohol 4/147 253/18722 0.138476230700649 0.293526417576686 ALAD/PRKAA2/FOS/SOD2 4 GO:0002700 regulation of production of molecular mediator of immune response 3/147 164/18722 0.138687129800567 0.293526417576686 SLC15A4/HLA-F/CD55 3 GO:0050680 negative regulation of epithelial cell proliferation 3/147 164/18722 0.138687129800567 0.293526417576686 ATOH8/MCC/GJA1 3 GO:0002483 antigen processing and presentation of endogenous peptide antigen 1/147 19/18722 0.13915762625334 0.293526417576686 HLA-F 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/147 19/18722 0.13915762625334 0.293526417576686 HLA-F 1 GO:0002902 regulation of B cell apoptotic process 1/147 19/18722 0.13915762625334 0.293526417576686 IRS2 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/147 19/18722 0.13915762625334 0.293526417576686 SOD2 1 GO:0007039 protein catabolic process in the vacuole 1/147 19/18722 0.13915762625334 0.293526417576686 VPS13A 1 GO:0007530 sex determination 1/147 19/18722 0.13915762625334 0.293526417576686 MAP3K4 1 GO:0016082 synaptic vesicle priming 1/147 19/18722 0.13915762625334 0.293526417576686 SNCA 1 GO:0031065 positive regulation of histone deacetylation 1/147 19/18722 0.13915762625334 0.293526417576686 VEGFA 1 GO:0031290 retinal ganglion cell axon guidance 1/147 19/18722 0.13915762625334 0.293526417576686 VEGFA 1 GO:0032026 response to magnesium ion 1/147 19/18722 0.13915762625334 0.293526417576686 SNCA 1 GO:0035728 response to hepatocyte growth factor 1/147 19/18722 0.13915762625334 0.293526417576686 GCLC 1 GO:0045603 positive regulation of endothelial cell differentiation 1/147 19/18722 0.13915762625334 0.293526417576686 ATOH8 1 GO:0046033 AMP metabolic process 1/147 19/18722 0.13915762625334 0.293526417576686 AK4 1 GO:0046716 muscle cell cellular homeostasis 1/147 19/18722 0.13915762625334 0.293526417576686 HIF1A 1 GO:0046782 regulation of viral transcription 1/147 19/18722 0.13915762625334 0.293526417576686 HEXIM1 1 GO:0060039 pericardium development 1/147 19/18722 0.13915762625334 0.293526417576686 SMAD3 1 GO:0060216 definitive hemopoiesis 1/147 19/18722 0.13915762625334 0.293526417576686 CBFB 1 GO:0070233 negative regulation of T cell apoptotic process 1/147 19/18722 0.13915762625334 0.293526417576686 HIF1A 1 GO:0070262 peptidyl-serine dephosphorylation 1/147 19/18722 0.13915762625334 0.293526417576686 PPP1R15A 1 GO:0070989 oxidative demethylation 1/147 19/18722 0.13915762625334 0.293526417576686 ALKBH5 1 GO:0086014 atrial cardiac muscle cell action potential 1/147 19/18722 0.13915762625334 0.293526417576686 GJA1 1 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 1/147 19/18722 0.13915762625334 0.293526417576686 GJA1 1 GO:0086066 atrial cardiac muscle cell to AV node cell communication 1/147 19/18722 0.13915762625334 0.293526417576686 GJA1 1 GO:1901659 glycosyl compound biosynthetic process 1/147 19/18722 0.13915762625334 0.293526417576686 MTAP 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/147 19/18722 0.13915762625334 0.293526417576686 HIF1A 1 GO:2000369 regulation of clathrin-dependent endocytosis 1/147 19/18722 0.13915762625334 0.293526417576686 DAB2 1 GO:0006839 mitochondrial transport 4/147 254/18722 0.139888474406704 0.294860061275865 HSPA1A/SLC25A37/GCLC/SLC25A29 4 GO:0050796 regulation of insulin secretion 3/147 165/18722 0.140491701697628 0.295213386809963 IRS2/GJA1/HIF1A 3 GO:0006112 energy reserve metabolic process 2/147 84/18722 0.141141806465479 0.295213386809963 IRS2/MYC 2 GO:0006405 RNA export from nucleus 2/147 84/18722 0.141141806465479 0.295213386809963 ALKBH5/RBM15B 2 GO:0006835 dicarboxylic acid transport 2/147 84/18722 0.141141806465479 0.295213386809963 SNCA/GJA1 2 GO:0010660 regulation of muscle cell apoptotic process 2/147 84/18722 0.141141806465479 0.295213386809963 STK4/SOD2 2 GO:0010921 regulation of phosphatase activity 2/147 84/18722 0.141141806465479 0.295213386809963 PPP1R15A/SMAD3 2 GO:0032945 negative regulation of mononuclear cell proliferation 2/147 84/18722 0.141141806465479 0.295213386809963 SHH/CEBPB 2 GO:0042310 vasoconstriction 2/147 84/18722 0.141141806465479 0.295213386809963 BDKRB2/GJA1 2 GO:0042440 pigment metabolic process 2/147 84/18722 0.141141806465479 0.295213386809963 PPARGC1A/ALAD 2 GO:0061157 mRNA destabilization 2/147 84/18722 0.141141806465479 0.295213386809963 TOB1/YTHDF2 2 GO:0098586 cellular response to virus 2/147 84/18722 0.141141806465479 0.295213386809963 SMAD3/HIF1A 2 GO:0051924 regulation of calcium ion transport 4/147 255/18722 0.141306531643216 0.2953513879419 SNCA/GEM/SLC30A1/GJA1 4 GO:0060538 skeletal muscle organ development 3/147 166/18722 0.142304240509795 0.297021621329237 SHH/FOS/MAFF 3 GO:0061013 regulation of mRNA catabolic process 3/147 166/18722 0.142304240509795 0.297021621329237 ALKBH5/TOB1/YTHDF2 3 GO:0090596 sensory organ morphogenesis 4/147 256/18722 0.142730359003318 0.297111953115866 VEGFA/TSKU/DLX5/HIF1A 4 GO:0002709 regulation of T cell mediated immunity 2/147 85/18722 0.143835556313546 0.297111953115866 HLA-F/CD55 2 GO:0009142 nucleoside triphosphate biosynthetic process 2/147 85/18722 0.143835556313546 0.297111953115866 PPARGC1A/AK4 2 GO:0060021 roof of mouth development 2/147 85/18722 0.143835556313546 0.297111953115866 SHH/DLX5 2 GO:0071277 cellular response to calcium ion 2/147 85/18722 0.143835556313546 0.297111953115866 PRKAA2/FOS 2 GO:0055088 lipid homeostasis 3/147 167/18722 0.144124646086716 0.297111953115866 PRKAA2/IRS2/TSKU 3 GO:1903034 regulation of response to wounding 3/147 167/18722 0.144124646086716 0.297111953115866 GJA1/PLAT/SMAD3 3 GO:0030217 T cell differentiation 4/147 257/18722 0.144159912883155 0.297111953115866 SOCS1/SHH/CBFB/PKNOX1 4 GO:0031348 negative regulation of defense response 4/147 258/18722 0.145595149487392 0.297111953115866 HLA-F/YTHDF2/SMAD3/SOCS3 4 GO:0006700 C21-steroid hormone biosynthetic process 1/147 20/18722 0.145923590480511 0.297111953115866 PPARGC1A 1 GO:0006837 serotonin transport 1/147 20/18722 0.145923590480511 0.297111953115866 SNCA 1 GO:0009713 catechol-containing compound biosynthetic process 1/147 20/18722 0.145923590480511 0.297111953115866 SNCA 1 GO:0010042 response to manganese ion 1/147 20/18722 0.145923590480511 0.297111953115866 SOD2 1 GO:0010893 positive regulation of steroid biosynthetic process 1/147 20/18722 0.145923590480511 0.297111953115866 PPARGC1A 1 GO:0017121 plasma membrane phospholipid scrambling 1/147 20/18722 0.145923590480511 0.297111953115866 PLSCR1 1 GO:0032332 positive regulation of chondrocyte differentiation 1/147 20/18722 0.145923590480511 0.297111953115866 SMAD3 1 GO:0032793 positive regulation of CREB transcription factor activity 1/147 20/18722 0.145923590480511 0.297111953115866 VEGFA 1 GO:0032986 protein-DNA complex disassembly 1/147 20/18722 0.145923590480511 0.297111953115866 MYC 1 GO:0042423 catecholamine biosynthetic process 1/147 20/18722 0.145923590480511 0.297111953115866 SNCA 1 GO:0043046 DNA methylation involved in gamete generation 1/147 20/18722 0.145923590480511 0.297111953115866 MOV10L1 1 GO:0043555 regulation of translation in response to stress 1/147 20/18722 0.145923590480511 0.297111953115866 PPP1R15A 1 GO:0043984 histone H4-K16 acetylation 1/147 20/18722 0.145923590480511 0.297111953115866 PIH1D1 1 GO:0045844 positive regulation of striated muscle tissue development 1/147 20/18722 0.145923590480511 0.297111953115866 SHH 1 GO:0048636 positive regulation of muscle organ development 1/147 20/18722 0.145923590480511 0.297111953115866 SHH 1 GO:0051900 regulation of mitochondrial depolarization 1/147 20/18722 0.145923590480511 0.297111953115866 GCLC 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/147 20/18722 0.145923590480511 0.297111953115866 GJA1 1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 1/147 20/18722 0.145923590480511 0.297111953115866 YTHDF2 1 GO:0070166 enamel mineralization 1/147 20/18722 0.145923590480511 0.297111953115866 WDR72 1 GO:0071243 cellular response to arsenic-containing substance 1/147 20/18722 0.145923590480511 0.297111953115866 ZFAND1 1 GO:0071379 cellular response to prostaglandin stimulus 1/147 20/18722 0.145923590480511 0.297111953115866 PRKAA2 1 GO:0090370 negative regulation of cholesterol efflux 1/147 20/18722 0.145923590480511 0.297111953115866 SHH 1 GO:0097320 plasma membrane tubulation 1/147 20/18722 0.145923590480511 0.297111953115866 PACSIN2 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/147 20/18722 0.145923590480511 0.297111953115866 GEM 1 GO:1901679 nucleotide transmembrane transport 1/147 20/18722 0.145923590480511 0.297111953115866 SLC35B2 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/147 20/18722 0.145923590480511 0.297111953115866 HSPA1A 1 GO:1904263 positive regulation of TORC1 signaling 1/147 20/18722 0.145923590480511 0.297111953115866 PIH1D1 1 GO:0009798 axis specification 2/147 86/18722 0.146540167140312 0.297355250961108 SHH/HOXD8 2 GO:0014031 mesenchymal cell development 2/147 86/18722 0.146540167140312 0.297355250961108 SHH/HIF1A 2 GO:0045921 positive regulation of exocytosis 2/147 86/18722 0.146540167140312 0.297355250961108 SNCA/HLA-F 2 GO:0046928 regulation of neurotransmitter secretion 2/147 86/18722 0.146540167140312 0.297355250961108 SNCA/SLC30A1 2 GO:0048864 stem cell development 2/147 86/18722 0.146540167140312 0.297355250961108 SHH/HIF1A 2 GO:0001776 leukocyte homeostasis 2/147 87/18722 0.149255305744029 0.301942113047685 SLC15A4/HIF1A 2 GO:0044070 regulation of anion transport 2/147 87/18722 0.149255305744029 0.301942113047685 SNCA/CEBPB 2 GO:0048041 focal adhesion assembly 2/147 87/18722 0.149255305744029 0.301942113047685 VEGFA/SMAD3 2 GO:0061014 positive regulation of mRNA catabolic process 2/147 87/18722 0.149255305744029 0.301942113047685 TOB1/YTHDF2 2 GO:0043487 regulation of RNA stability 3/147 170/18722 0.149632062303984 0.301942113047685 ALKBH5/TOB1/YTHDF2 3 GO:0009314 response to radiation 6/147 456/18722 0.150002683114015 0.301942113047685 ALAD/FOS/MAP3K4/MYC/SOD2/HIF1A 6 GO:0010631 epithelial cell migration 5/147 357/18722 0.15024291639925 0.301942113047685 ATOH8/MCC/CTSH/VEGFA/HIF1A 5 GO:0031330 negative regulation of cellular catabolic process 4/147 262/18722 0.151392040845077 0.301942113047685 SNCA/SHH/ALAD/TOB1 4 GO:0042129 regulation of T cell proliferation 3/147 171/18722 0.151482934066752 0.301942113047685 SHH/CD55/CEBPB 3 GO:0009144 purine nucleoside triphosphate metabolic process 2/147 88/18722 0.151980643419508 0.301942113047685 PPARGC1A/AK4 2 GO:0010232 vascular transport 2/147 88/18722 0.151980643419508 0.301942113047685 GJA1/SLC7A2 2 GO:0050779 RNA destabilization 2/147 88/18722 0.151980643419508 0.301942113047685 TOB1/YTHDF2 2 GO:0000002 mitochondrial genome maintenance 1/147 21/18722 0.152636735181578 0.301942113047685 PPARGC1A 1 GO:0007350 blastoderm segmentation 1/147 21/18722 0.152636735181578 0.301942113047685 HOXD8 1 GO:0009067 aspartate family amino acid biosynthetic process 1/147 21/18722 0.152636735181578 0.301942113047685 MTAP 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/147 21/18722 0.152636735181578 0.301942113047685 CNPY2 1 GO:0023019 signal transduction involved in regulation of gene expression 1/147 21/18722 0.152636735181578 0.301942113047685 SMAD3 1 GO:0030502 negative regulation of bone mineralization 1/147 21/18722 0.152636735181578 0.301942113047685 HIF1A 1 GO:0031998 regulation of fatty acid beta-oxidation 1/147 21/18722 0.152636735181578 0.301942113047685 IRS2 1 GO:0032288 myelin assembly 1/147 21/18722 0.152636735181578 0.301942113047685 EPB41L3 1 GO:0032516 positive regulation of phosphoprotein phosphatase activity 1/147 21/18722 0.152636735181578 0.301942113047685 PPP1R15A 1 GO:0034035 purine ribonucleoside bisphosphate metabolic process 1/147 21/18722 0.152636735181578 0.301942113047685 SLC35B2 1 GO:0034471 ncRNA 5'-end processing 1/147 21/18722 0.152636735181578 0.301942113047685 NOP14 1 GO:0038083 peptidyl-tyrosine autophosphorylation 1/147 21/18722 0.152636735181578 0.301942113047685 VEGFA 1 GO:0044342 type B pancreatic cell proliferation 1/147 21/18722 0.152636735181578 0.301942113047685 IGFBP4 1 GO:0044766 multi-organism transport 1/147 21/18722 0.152636735181578 0.301942113047685 IFIT1 1 GO:0045655 regulation of monocyte differentiation 1/147 21/18722 0.152636735181578 0.301942113047685 MYC 1 GO:0046128 purine ribonucleoside metabolic process 1/147 21/18722 0.152636735181578 0.301942113047685 MTAP 1 GO:0046641 positive regulation of alpha-beta T cell proliferation 1/147 21/18722 0.152636735181578 0.301942113047685 CD55 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/147 21/18722 0.152636735181578 0.301942113047685 SHH 1 GO:0048745 smooth muscle tissue development 1/147 21/18722 0.152636735181578 0.301942113047685 SHH 1 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 1/147 21/18722 0.152636735181578 0.301942113047685 SLC35B2 1 GO:0060445 branching involved in salivary gland morphogenesis 1/147 21/18722 0.152636735181578 0.301942113047685 SHH 1 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 1/147 21/18722 0.152636735181578 0.301942113047685 VEGFA 1 GO:0150146 cell junction disassembly 1/147 21/18722 0.152636735181578 0.301942113047685 DKK1 1 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1/147 21/18722 0.152636735181578 0.301942113047685 BDKRB2 1 GO:1902579 multi-organism localization 1/147 21/18722 0.152636735181578 0.301942113047685 IFIT1 1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 1/147 21/18722 0.152636735181578 0.301942113047685 VEGFA 1 GO:0002221 pattern recognition receptor signaling pathway 3/147 172/18722 0.153341172432782 0.302734948347493 SLC15A4/HSPA1A/HSPA1B 3 GO:0048736 appendage development 3/147 172/18722 0.153341172432782 0.302734948347493 SHH/DLX5/DKK1 3 GO:0060173 limb development 3/147 172/18722 0.153341172432782 0.302734948347493 SHH/DLX5/DKK1 3 GO:0090132 epithelium migration 5/147 360/18722 0.153943696042895 0.303724007166425 ATOH8/MCC/CTSH/VEGFA/HIF1A 5 GO:0009199 ribonucleoside triphosphate metabolic process 2/147 89/18722 0.154715855908857 0.3044441611996 PPARGC1A/AK4 2 GO:0010657 muscle cell apoptotic process 2/147 89/18722 0.154715855908857 0.3044441611996 STK4/SOD2 2 GO:0051781 positive regulation of cell division 2/147 89/18722 0.154715855908857 0.3044441611996 SHH/VEGFA 2 GO:1900407 regulation of cellular response to oxidative stress 2/147 89/18722 0.154715855908857 0.3044441611996 SOD2/HIF1A 2 GO:0010469 regulation of signaling receptor activity 3/147 173/18722 0.155206677580335 0.305209186484406 PPARGC1A/HIF1A/DKK1 3 GO:0007584 response to nutrient 3/147 174/18722 0.157079349787453 0.306601500942316 ALAD/GCLC/SOD2 3 GO:0045619 regulation of lymphocyte differentiation 3/147 174/18722 0.157079349787453 0.306601500942316 SOCS1/SHH/CBFB 3 GO:0030901 midbrain development 2/147 90/18722 0.157460623352722 0.306601500942316 SHH/ZNF430 2 GO:0042475 odontogenesis of dentin-containing tooth 2/147 90/18722 0.157460623352722 0.306601500942316 SHH/WDR72 2 GO:0070664 negative regulation of leukocyte proliferation 2/147 90/18722 0.157460623352722 0.306601500942316 SHH/CEBPB 2 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 2/147 90/18722 0.157460623352722 0.306601500942316 GJA1/SOD2 2 GO:0016570 histone modification 6/147 463/18722 0.15761101628164 0.306601500942316 PPARGC1A/SNCA/NNMT/PRKAA2/VEGFA/PIH1D1 6 GO:0023061 signal release 6/147 463/18722 0.15761101628164 0.306601500942316 SNCA/SLC30A1/DNAJC5/IRS2/GJA1/HIF1A 6 GO:0002320 lymphoid progenitor cell differentiation 1/147 22/18722 0.159297469897813 0.306601500942316 SHH 1 GO:0007398 ectoderm development 1/147 22/18722 0.159297469897813 0.306601500942316 SHH 1 GO:0021904 dorsal/ventral neural tube patterning 1/147 22/18722 0.159297469897813 0.306601500942316 SHH 1 GO:0031061 negative regulation of histone methylation 1/147 22/18722 0.159297469897813 0.306601500942316 PIH1D1 1 GO:0032069 regulation of nuclease activity 1/147 22/18722 0.159297469897813 0.306601500942316 HSPA1A 1 GO:0032402 melanosome transport 1/147 22/18722 0.159297469897813 0.306601500942316 MLPH 1 GO:0032816 positive regulation of natural killer cell activation 1/147 22/18722 0.159297469897813 0.306601500942316 HLA-F 1 GO:0032891 negative regulation of organic acid transport 1/147 22/18722 0.159297469897813 0.306601500942316 IRS2 1 GO:0035561 regulation of chromatin binding 1/147 22/18722 0.159297469897813 0.306601500942316 PARP9 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/147 22/18722 0.159297469897813 0.306601500942316 CBFB 1 GO:0044346 fibroblast apoptotic process 1/147 22/18722 0.159297469897813 0.306601500942316 MYC 1 GO:0045061 thymic T cell selection 1/147 22/18722 0.159297469897813 0.306601500942316 SHH 1 GO:0048169 regulation of long-term neuronal synaptic plasticity 1/147 22/18722 0.159297469897813 0.306601500942316 SNCA 1 GO:0051151 negative regulation of smooth muscle cell differentiation 1/147 22/18722 0.159297469897813 0.306601500942316 SHH 1 GO:0051412 response to corticosterone 1/147 22/18722 0.159297469897813 0.306601500942316 FOS 1 GO:0060563 neuroepithelial cell differentiation 1/147 22/18722 0.159297469897813 0.306601500942316 CEBPB 1 GO:0060713 labyrinthine layer morphogenesis 1/147 22/18722 0.159297469897813 0.306601500942316 SOCS3 1 GO:0061042 vascular wound healing 1/147 22/18722 0.159297469897813 0.306601500942316 VEGFA 1 GO:0071359 cellular response to dsRNA 1/147 22/18722 0.159297469897813 0.306601500942316 IFIT1 1 GO:0072574 hepatocyte proliferation 1/147 22/18722 0.159297469897813 0.306601500942316 CEBPB 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/147 22/18722 0.159297469897813 0.306601500942316 CEBPB 1 GO:0140467 integrated stress response signaling 1/147 22/18722 0.159297469897813 0.306601500942316 PPP1R15A 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/147 22/18722 0.159297469897813 0.306601500942316 PPARGC1A 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/147 22/18722 0.159297469897813 0.306601500942316 VEGFA 1 GO:2000725 regulation of cardiac muscle cell differentiation 1/147 22/18722 0.159297469897813 0.306601500942316 DKK1 1 GO:0090130 tissue migration 5/147 365/18722 0.160195890096119 0.307249141169737 ATOH8/MCC/CTSH/VEGFA/HIF1A 5 GO:0002065 columnar/cuboidal epithelial cell differentiation 2/147 91/18722 0.160214630241997 0.307249141169737 HIF1A/CEBPB 2 GO:0006354 DNA-templated transcription, elongation 2/147 91/18722 0.160214630241997 0.307249141169737 SHH/HEXIM1 2 GO:0014033 neural crest cell differentiation 2/147 91/18722 0.160214630241997 0.307249141169737 SHH/HIF1A 2 GO:1990874 vascular associated smooth muscle cell proliferation 2/147 91/18722 0.160214630241997 0.307249141169737 GJA1/SOD2 2 GO:0001894 tissue homeostasis 4/147 268/18722 0.160250304321227 0.307249141169737 IGKC/CTSH/VEGFA/GJA1 4 GO:0061564 axon development 6/147 467/18722 0.162034063098071 0.309753712385294 SHH/TRIO/SLITRK4/VEGFA/TSKU/DLX5 6 GO:0140694 non-membrane-bounded organelle assembly 5/147 367/18722 0.16272566170014 0.309753712385294 HSPA1A/PRKAA2/YTHDF2/HSPA1B/CCDC57 5 GO:0043405 regulation of MAP kinase activity 3/147 177/18722 0.162739373297206 0.309753712385294 VEGFA/MAP3K4/DKK1 3 GO:0051302 regulation of cell division 3/147 177/18722 0.162739373297206 0.309753712385294 SHH/VEGFA/MYC 3 GO:0001708 cell fate specification 2/147 92/18722 0.162977565370019 0.309753712385294 SHH/DKK1 2 GO:0070509 calcium ion import 2/147 92/18722 0.162977565370019 0.309753712385294 SLC30A1/TRPC4 2 GO:0002764 immune response-regulating signaling pathway 6/147 468/18722 0.163148237863029 0.309753712385294 IGKC/PLSCR1/SLC15A4/HSPA1A/CTSH/HSPA1B 6 GO:0007589 body fluid secretion 2/147 93/18722 0.165749121785241 0.309753712385294 VEGFA/HIF1A 2 GO:0033273 response to vitamin 2/147 93/18722 0.165749121785241 0.309753712385294 ALAD/SOD2 2 GO:0045185 maintenance of protein location 2/147 93/18722 0.165749121785241 0.309753712385294 VPS13A/GJA1 2 GO:0060349 bone morphogenesis 2/147 93/18722 0.165749121785241 0.309753712385294 TSKU/DLX5 2 GO:0097306 cellular response to alcohol 2/147 93/18722 0.165749121785241 0.309753712385294 PRKAA2/SOD2 2 GO:1901796 regulation of signal transduction by p53 class mediator 2/147 93/18722 0.165749121785241 0.309753712385294 BDKRB2/HEXIM1 2 GO:0000966 RNA 5'-end processing 1/147 23/18722 0.165906201016798 0.309753712385294 NOP14 1 GO:0001759 organ induction 1/147 23/18722 0.165906201016798 0.309753712385294 DKK1 1 GO:0001919 regulation of receptor recycling 1/147 23/18722 0.165906201016798 0.309753712385294 SNCA 1 GO:0006929 substrate-dependent cell migration 1/147 23/18722 0.165906201016798 0.309753712385294 STK4 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/147 23/18722 0.165906201016798 0.309753712385294 SNCA 1 GO:0019430 removal of superoxide radicals 1/147 23/18722 0.165906201016798 0.309753712385294 SOD2 1 GO:0021871 forebrain regionalization 1/147 23/18722 0.165906201016798 0.309753712385294 SHH 1 GO:0030325 adrenal gland development 1/147 23/18722 0.165906201016798 0.309753712385294 SMAD3 1 GO:0030539 male genitalia development 1/147 23/18722 0.165906201016798 0.309753712385294 SHH 1 GO:0031338 regulation of vesicle fusion 1/147 23/18722 0.165906201016798 0.309753712385294 SNCA 1 GO:0032401 establishment of melanosome localization 1/147 23/18722 0.165906201016798 0.309753712385294 MLPH 1 GO:0033081 regulation of T cell differentiation in thymus 1/147 23/18722 0.165906201016798 0.309753712385294 SHH 1 GO:0034695 response to prostaglandin E 1/147 23/18722 0.165906201016798 0.309753712385294 PRKAA2 1 GO:0035994 response to muscle stretch 1/147 23/18722 0.165906201016798 0.309753712385294 FOS 1 GO:0036303 lymph vessel morphogenesis 1/147 23/18722 0.165906201016798 0.309753712385294 VEGFA 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/147 23/18722 0.165906201016798 0.309753712385294 SHH 1 GO:0045943 positive regulation of transcription by RNA polymerase I 1/147 23/18722 0.165906201016798 0.309753712385294 PIH1D1 1 GO:0045980 negative regulation of nucleotide metabolic process 1/147 23/18722 0.165906201016798 0.309753712385294 PPARGC1A 1 GO:0050765 negative regulation of phagocytosis 1/147 23/18722 0.165906201016798 0.309753712385294 PLSCR1 1 GO:0051590 positive regulation of neurotransmitter transport 1/147 23/18722 0.165906201016798 0.309753712385294 SNCA 1 GO:0051882 mitochondrial depolarization 1/147 23/18722 0.165906201016798 0.309753712385294 GCLC 1 GO:0051904 pigment granule transport 1/147 23/18722 0.165906201016798 0.309753712385294 MLPH 1 GO:0060396 growth hormone receptor signaling pathway 1/147 23/18722 0.165906201016798 0.309753712385294 GH2 1 GO:0060575 intestinal epithelial cell differentiation 1/147 23/18722 0.165906201016798 0.309753712385294 HIF1A 1 GO:0071636 positive regulation of transforming growth factor beta production 1/147 23/18722 0.165906201016798 0.309753712385294 SMAD3 1 GO:0072576 liver morphogenesis 1/147 23/18722 0.165906201016798 0.309753712385294 CEBPB 1 GO:1903306 negative regulation of regulated secretory pathway 1/147 23/18722 0.165906201016798 0.309753712385294 HLA-F 1 GO:2000737 negative regulation of stem cell differentiation 1/147 23/18722 0.165906201016798 0.309753712385294 YTHDF2 1 GO:2000810 regulation of bicellular tight junction assembly 1/147 23/18722 0.165906201016798 0.309753712385294 GJA1 1 GO:0007416 synapse assembly 3/147 179/18722 0.166546734945319 0.310755635821241 SNCA/SLITRK4/TPBG 3 GO:0007159 leukocyte cell-cell adhesion 5/147 371/18722 0.167833613242706 0.312961556863425 SOCS1/SHH/CBFB/CD55/CEBPB 5 GO:0048660 regulation of smooth muscle cell proliferation 3/147 180/18722 0.168460322438635 0.313087098920741 PPARGC1A/GJA1/SOD2 3 GO:0071897 DNA biosynthetic process 3/147 180/18722 0.168460322438635 0.313087098920741 GJA1/MAP3K4/MYC 3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 2/147 94/18722 0.168528996744364 0.313087098920741 CCNH/HEXIM1 2 GO:0001738 morphogenesis of a polarized epithelium 2/147 94/18722 0.168528996744364 0.313087098920741 DAB2/DKK1 2 GO:0019080 viral gene expression 2/147 94/18722 0.168528996744364 0.313087098920741 HEXIM1/PARP9 2 GO:0030316 osteoclast differentiation 2/147 94/18722 0.168528996744364 0.313087098920741 FOS/CEBPB 2 GO:0031667 response to nutrient levels 6/147 474/18722 0.169902703598128 0.314152147017949 PPARGC1A/GH2/ALAD/PRKAA2/GCLC/SOD2 6 GO:1905952 regulation of lipid localization 3/147 181/18722 0.170380382722778 0.314152147017949 SHH/PLIN2/IRS2 3 GO:0007044 cell-substrate junction assembly 2/147 95/18722 0.171316891665948 0.314152147017949 VEGFA/SMAD3 2 GO:0008585 female gonad development 2/147 95/18722 0.171316891665948 0.314152147017949 VEGFA/CEBPB 2 GO:0036473 cell death in response to oxidative stress 2/147 95/18722 0.171316891665948 0.314152147017949 SOD2/HIF1A 2 GO:0048709 oligodendrocyte differentiation 2/147 95/18722 0.171316891665948 0.314152147017949 SHH/TRPC4 2 GO:0030098 lymphocyte differentiation 5/147 374/18722 0.171706116221701 0.314152147017949 SOCS1/SHH/CBFB/PKNOX1/TPD52 5 GO:1903829 positive regulation of cellular protein localization 4/147 276/18722 0.172350222594952 0.314152147017949 SHH/PRKAA2/PARP9/SMAD3 4 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/147 24/18722 0.172463331796547 0.314152147017949 NOP14 1 GO:0001783 B cell apoptotic process 1/147 24/18722 0.172463331796547 0.314152147017949 IRS2 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/147 24/18722 0.172463331796547 0.314152147017949 HLA-F 1 GO:0002021 response to dietary excess 1/147 24/18722 0.172463331796547 0.314152147017949 PPARGC1A 1 GO:0002726 positive regulation of T cell cytokine production 1/147 24/18722 0.172463331796547 0.314152147017949 CD55 1 GO:0006817 phosphate ion transport 1/147 24/18722 0.172463331796547 0.314152147017949 CEBPB 1 GO:0010226 response to lithium ion 1/147 24/18722 0.172463331796547 0.314152147017949 SHH 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/147 24/18722 0.172463331796547 0.314152147017949 PPARGC1A 1 GO:0031639 plasminogen activation 1/147 24/18722 0.172463331796547 0.314152147017949 PLAT 1 GO:0036010 protein localization to endosome 1/147 24/18722 0.172463331796547 0.314152147017949 PACSIN2 1 GO:0043302 positive regulation of leukocyte degranulation 1/147 24/18722 0.172463331796547 0.314152147017949 HLA-F 1 GO:0048641 regulation of skeletal muscle tissue development 1/147 24/18722 0.172463331796547 0.314152147017949 SHH 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/147 24/18722 0.172463331796547 0.314152147017949 HIF1A 1 GO:0051570 regulation of histone H3-K9 methylation 1/147 24/18722 0.172463331796547 0.314152147017949 PIH1D1 1 GO:0051905 establishment of pigment granule localization 1/147 24/18722 0.172463331796547 0.314152147017949 MLPH 1 GO:0060561 apoptotic process involved in morphogenesis 1/147 24/18722 0.172463331796547 0.314152147017949 PPP2R1B 1 GO:0071378 cellular response to growth hormone stimulus 1/147 24/18722 0.172463331796547 0.314152147017949 GH2 1 GO:0072530 purine-containing compound transmembrane transport 1/147 24/18722 0.172463331796547 0.314152147017949 SLC35B2 1 GO:0120255 olefinic compound biosynthetic process 1/147 24/18722 0.172463331796547 0.314152147017949 PPARGC1A 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/147 24/18722 0.172463331796547 0.314152147017949 PPARGC1A 1 GO:1903077 negative regulation of protein localization to plasma membrane 1/147 24/18722 0.172463331796547 0.314152147017949 DAB2 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/147 24/18722 0.172463331796547 0.314152147017949 SOD2 1 GO:2000310 regulation of NMDA receptor activity 1/147 24/18722 0.172463331796547 0.314152147017949 PPARGC1A 1 GO:2001026 regulation of endothelial cell chemotaxis 1/147 24/18722 0.172463331796547 0.314152147017949 VEGFA 1 GO:0002718 regulation of cytokine production involved in immune response 2/147 96/18722 0.17411251208447 0.31619339626269 HLA-F/CD55 2 GO:0003073 regulation of systemic arterial blood pressure 2/147 96/18722 0.17411251208447 0.31619339626269 GJA1/SOD2 2 GO:0030510 regulation of BMP signaling pathway 2/147 96/18722 0.17411251208447 0.31619339626269 HTRA3/TOB1 2 GO:0035282 segmentation 2/147 96/18722 0.17411251208447 0.31619339626269 SMAD3/HOXD8 2 GO:0043648 dicarboxylic acid metabolic process 2/147 96/18722 0.17411251208447 0.31619339626269 ALDH5A1/GCLC 2 GO:0022898 regulation of transmembrane transporter activity 4/147 278/18722 0.175424340404347 0.31838240421687 PPARGC1A/SNCA/GEM/GJA1 4 GO:0048659 smooth muscle cell proliferation 3/147 184/18722 0.176178416270333 0.319389656209316 PPARGC1A/GJA1/SOD2 3 GO:0043410 positive regulation of MAPK cascade 6/147 480/18722 0.176773571536251 0.319389656209316 TPBG/VEGFA/MAP3K4/IGFBP4/IGFBP6/DKK1 6 GO:0014909 smooth muscle cell migration 2/147 97/18722 0.176915567604854 0.319389656209316 PPARGC1A/PLAT 2 GO:0030900 forebrain development 5/147 379/18722 0.178237301987586 0.319389656209316 PPARGC1A/SHH/TSKU/DLX5/HIF1A 5 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 1/147 25/18722 0.17896926238944 0.319389656209316 GJA1 1 GO:0003094 glomerular filtration 1/147 25/18722 0.17896926238944 0.319389656209316 GJA1 1 GO:0006658 phosphatidylserine metabolic process 1/147 25/18722 0.17896926238944 0.319389656209316 PLSCR1 1 GO:0015874 norepinephrine transport 1/147 25/18722 0.17896926238944 0.319389656209316 SNCA 1 GO:0016540 protein autoprocessing 1/147 25/18722 0.17896926238944 0.319389656209316 SHH 1 GO:0031579 membrane raft organization 1/147 25/18722 0.17896926238944 0.319389656209316 PACSIN2 1 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1/147 25/18722 0.17896926238944 0.319389656209316 CD55 1 GO:0032400 melanosome localization 1/147 25/18722 0.17896926238944 0.319389656209316 MLPH 1 GO:0032753 positive regulation of interleukin-4 production 1/147 25/18722 0.17896926238944 0.319389656209316 CEBPB 1 GO:0032925 regulation of activin receptor signaling pathway 1/147 25/18722 0.17896926238944 0.319389656209316 SHH 1 GO:0034389 lipid droplet organization 1/147 25/18722 0.17896926238944 0.319389656209316 PTGFRN 1 GO:0042730 fibrinolysis 1/147 25/18722 0.17896926238944 0.319389656209316 PLAT 1 GO:0045109 intermediate filament organization 1/147 25/18722 0.17896926238944 0.319389656209316 SHH 1 GO:0046039 GTP metabolic process 1/147 25/18722 0.17896926238944 0.319389656209316 AK4 1 GO:0051450 myoblast proliferation 1/147 25/18722 0.17896926238944 0.319389656209316 ATOH8 1 GO:0060740 prostate gland epithelium morphogenesis 1/147 25/18722 0.17896926238944 0.319389656209316 SHH 1 GO:0070199 establishment of protein localization to chromosome 1/147 25/18722 0.17896926238944 0.319389656209316 PIH1D1 1 GO:0071450 cellular response to oxygen radical 1/147 25/18722 0.17896926238944 0.319389656209316 SOD2 1 GO:0071451 cellular response to superoxide 1/147 25/18722 0.17896926238944 0.319389656209316 SOD2 1 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 1/147 25/18722 0.17896926238944 0.319389656209316 GJA1 1 GO:0090382 phagosome maturation 1/147 25/18722 0.17896926238944 0.319389656209316 SRPX 1 GO:1901798 positive regulation of signal transduction by p53 class mediator 1/147 25/18722 0.17896926238944 0.319389656209316 HEXIM1 1 GO:1902932 positive regulation of alcohol biosynthetic process 1/147 25/18722 0.17896926238944 0.319389656209316 SNCA 1 GO:1903055 positive regulation of extracellular matrix organization 1/147 25/18722 0.17896926238944 0.319389656209316 SMAD3 1 GO:0002367 cytokine production involved in immune response 2/147 98/18722 0.179725771857437 0.3199760616819 HLA-F/CD55 2 GO:0043502 regulation of muscle adaptation 2/147 98/18722 0.179725771857437 0.3199760616819 PPARGC1A/SMAD3 2 GO:1902882 regulation of response to oxidative stress 2/147 98/18722 0.179725771857437 0.3199760616819 SOD2/HIF1A 2 GO:1904029 regulation of cyclin-dependent protein kinase activity 2/147 98/18722 0.179725771857437 0.3199760616819 CCNH/HEXIM1 2 GO:0008217 regulation of blood pressure 3/147 186/18722 0.180074335515114 0.320215420645486 GJA1/SMAD3/SOD2 3 GO:1902115 regulation of organelle assembly 3/147 186/18722 0.180074335515114 0.320215420645486 HSPA1A/PRKAA2/HSPA1B 3 GO:0031341 regulation of cell killing 2/147 99/18722 0.182542842453398 0.32206988971494 HLA-F/CD55 2 GO:0033209 tumor necrosis factor-mediated signaling pathway 2/147 99/18722 0.182542842453398 0.32206988971494 HSPA1A/HSPA1B 2 GO:0034660 ncRNA metabolic process 6/147 485/18722 0.182585556380885 0.32206988971494 DUS1L/NOP14/MOV10L1/YTHDF2/SMAD3/PIH1D1 6 GO:0001906 cell killing 3/147 188/18722 0.183993794843807 0.32206988971494 HLA-F/CTSH/CD55 3 GO:0048839 inner ear development 3/147 188/18722 0.183993794843807 0.32206988971494 SHH/TSKU/DLX5 3 GO:0022409 positive regulation of cell-cell adhesion 4/147 284/18722 0.184758671615274 0.32206988971494 SOCS1/SHH/CBFB/CD55 4 GO:0072659 protein localization to plasma membrane 4/147 284/18722 0.184758671615274 0.32206988971494 TPBG/EPB41L3/WDR72/DAB2 4 GO:0006910 phagocytosis, recognition 2/147 100/18722 0.185366500940624 0.32206988971494 IGKC/C4BPA 2 GO:0046545 development of primary female sexual characteristics 2/147 100/18722 0.185366500940624 0.32206988971494 VEGFA/CEBPB 2 GO:0051588 regulation of neurotransmitter transport 2/147 100/18722 0.185366500940624 0.32206988971494 SNCA/SLC30A1 2 GO:0060840 artery development 2/147 100/18722 0.185366500940624 0.32206988971494 SHH/VEGFA 2 GO:0001556 oocyte maturation 1/147 26/18722 0.185424389865974 0.32206988971494 YTHDF2 1 GO:0001963 synaptic transmission, dopaminergic 1/147 26/18722 0.185424389865974 0.32206988971494 SNCA 1 GO:0002710 negative regulation of T cell mediated immunity 1/147 26/18722 0.185424389865974 0.32206988971494 HLA-F 1 GO:0003416 endochondral bone growth 1/147 26/18722 0.185424389865974 0.32206988971494 TSKU 1 GO:0006027 glycosaminoglycan catabolic process 1/147 26/18722 0.185424389865974 0.32206988971494 IDS 1 GO:0018027 peptidyl-lysine dimethylation 1/147 26/18722 0.185424389865974 0.32206988971494 PIH1D1 1 GO:0019883 antigen processing and presentation of endogenous antigen 1/147 26/18722 0.185424389865974 0.32206988971494 HLA-F 1 GO:0021952 central nervous system projection neuron axonogenesis 1/147 26/18722 0.185424389865974 0.32206988971494 TSKU 1 GO:0032515 negative regulation of phosphoprotein phosphatase activity 1/147 26/18722 0.185424389865974 0.32206988971494 PPP1R15A 1 GO:0033598 mammary gland epithelial cell proliferation 1/147 26/18722 0.185424389865974 0.32206988971494 CEBPB 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/147 26/18722 0.185424389865974 0.32206988971494 HIF1A 1 GO:0042278 purine nucleoside metabolic process 1/147 26/18722 0.185424389865974 0.32206988971494 MTAP 1 GO:0042634 regulation of hair cycle 1/147 26/18722 0.185424389865974 0.32206988971494 TSKU 1 GO:0043094 cellular metabolic compound salvage 1/147 26/18722 0.185424389865974 0.32206988971494 MTAP 1 GO:0043501 skeletal muscle adaptation 1/147 26/18722 0.185424389865974 0.32206988971494 PPARGC1A 1 GO:0045672 positive regulation of osteoclast differentiation 1/147 26/18722 0.185424389865974 0.32206988971494 FOS 1 GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 1/147 26/18722 0.185424389865974 0.32206988971494 SLC39A14 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/147 26/18722 0.185424389865974 0.32206988971494 HLA-F 1 GO:0046697 decidualization 1/147 26/18722 0.185424389865974 0.32206988971494 GJA1 1 GO:0047497 mitochondrion transport along microtubule 1/147 26/18722 0.185424389865974 0.32206988971494 HIF1A 1 GO:0051875 pigment granule localization 1/147 26/18722 0.185424389865974 0.32206988971494 MLPH 1 GO:0060669 embryonic placenta morphogenesis 1/147 26/18722 0.185424389865974 0.32206988971494 SOCS3 1 GO:0071425 hematopoietic stem cell proliferation 1/147 26/18722 0.185424389865974 0.32206988971494 YTHDF2 1 GO:0097186 amelogenesis 1/147 26/18722 0.185424389865974 0.32206988971494 WDR72 1 GO:0097205 renal filtration 1/147 26/18722 0.185424389865974 0.32206988971494 GJA1 1 GO:1900017 positive regulation of cytokine production involved in inflammatory response 1/147 26/18722 0.185424389865974 0.32206988971494 HIF1A 1 GO:1904353 regulation of telomere capping 1/147 26/18722 0.185424389865974 0.32206988971494 MAP3K4 1 GO:1904376 negative regulation of protein localization to cell periphery 1/147 26/18722 0.185424389865974 0.32206988971494 DAB2 1 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 1/147 26/18722 0.185424389865974 0.32206988971494 SOD2 1 GO:0009060 aerobic respiration 3/147 189/18722 0.185962109311759 0.322816406820354 SNCA/AK4/HIF1A 3 GO:0048562 embryonic organ morphogenesis 4/147 285/18722 0.186330231602306 0.323267820604697 SHH/SMAD3/DLX5/HIF1A 4 GO:0006576 cellular biogenic amine metabolic process 2/147 101/18722 0.188196472760014 0.325749797468288 SNCA/NNMT 2 GO:0042102 positive regulation of T cell proliferation 2/147 101/18722 0.188196472760014 0.325749797468288 SHH/CD55 2 GO:0098869 cellular oxidant detoxification 2/147 101/18722 0.188196472760014 0.325749797468288 HBG1/SOD2 2 GO:0150115 cell-substrate junction organization 2/147 101/18722 0.188196472760014 0.325749797468288 VEGFA/SMAD3 2 GO:0001841 neural tube formation 2/147 102/18722 0.191032487202224 0.327489076906887 STK4/HIF1A 2 GO:0032677 regulation of interleukin-8 production 2/147 102/18722 0.191032487202224 0.327489076906887 HSPA1A/HSPA1B 2 GO:1904063 negative regulation of cation transmembrane transport 2/147 102/18722 0.191032487202224 0.327489076906887 GEM/SLC30A1 2 GO:1990542 mitochondrial transmembrane transport 2/147 102/18722 0.191032487202224 0.327489076906887 SLC25A37/SLC25A29 2 GO:0046651 lymphocyte proliferation 4/147 288/18722 0.191071121822024 0.327489076906887 SHH/IRS2/CD55/CEBPB 4 GO:1903311 regulation of mRNA metabolic process 4/147 288/18722 0.191071121822024 0.327489076906887 ALKBH5/TOB1/YTHDF2/RBM15B 4 GO:0000469 cleavage involved in rRNA processing 1/147 27/18722 0.191829108238337 0.327489076906887 NOP14 1 GO:0001958 endochondral ossification 1/147 27/18722 0.191829108238337 0.327489076906887 DLX5 1 GO:0002719 negative regulation of cytokine production involved in immune response 1/147 27/18722 0.191829108238337 0.327489076906887 HLA-F 1 GO:0003401 axis elongation 1/147 27/18722 0.191829108238337 0.327489076906887 SHH 1 GO:0006783 heme biosynthetic process 1/147 27/18722 0.191829108238337 0.327489076906887 ALAD 1 GO:0007263 nitric oxide mediated signal transduction 1/147 27/18722 0.191829108238337 0.327489076906887 VEGFA 1 GO:0009651 response to salt stress 1/147 27/18722 0.191829108238337 0.327489076906887 BDKRB2 1 GO:0016556 mRNA modification 1/147 27/18722 0.191829108238337 0.327489076906887 PCIF1 1 GO:0031954 positive regulation of protein autophosphorylation 1/147 27/18722 0.191829108238337 0.327489076906887 VEGFA 1 GO:0033688 regulation of osteoblast proliferation 1/147 27/18722 0.191829108238337 0.327489076906887 SMAD3 1 GO:0034505 tooth mineralization 1/147 27/18722 0.191829108238337 0.327489076906887 WDR72 1 GO:0035116 embryonic hindlimb morphogenesis 1/147 27/18722 0.191829108238337 0.327489076906887 SHH 1 GO:0036075 replacement ossification 1/147 27/18722 0.191829108238337 0.327489076906887 DLX5 1 GO:0048520 positive regulation of behavior 1/147 27/18722 0.191829108238337 0.327489076906887 GJA1 1 GO:0051953 negative regulation of amine transport 1/147 27/18722 0.191829108238337 0.327489076906887 SNCA 1 GO:0060512 prostate gland morphogenesis 1/147 27/18722 0.191829108238337 0.327489076906887 SHH 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/147 27/18722 0.191829108238337 0.327489076906887 HIF1A 1 GO:1903421 regulation of synaptic vesicle recycling 1/147 27/18722 0.191829108238337 0.327489076906887 SNCA 1 GO:0051656 establishment of organelle localization 5/147 390/18722 0.192929764823921 0.329180220529576 SNCA/GEM/MLPH/GJA1/HIF1A 5 GO:0032637 interleukin-8 production 2/147 103/18722 0.193874277364843 0.330254003432307 HSPA1A/HSPA1B 2 GO:0007565 female pregnancy 3/147 193/18722 0.193890347718867 0.330254003432307 FOS/VEGFA/GJA1 3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 3/147 193/18722 0.193890347718867 0.330254003432307 GH2/VEGFA/PARP9 3 GO:0032943 mononuclear cell proliferation 4/147 291/18722 0.195850336260399 0.333273064512609 SHH/IRS2/CD55/CEBPB 4 GO:1901654 response to ketone 3/147 194/18722 0.195885672822857 0.333273064512609 PRKAA2/FOS/MTAP 3 GO:0048661 positive regulation of smooth muscle cell proliferation 2/147 104/18722 0.19672158010999 0.333765636922889 PPARGC1A/GJA1 2 GO:0030073 insulin secretion 3/147 195/18722 0.19788611331666 0.333765636922889 IRS2/GJA1/HIF1A 3 GO:1901605 alpha-amino acid metabolic process 3/147 195/18722 0.19788611331666 0.333765636922889 MTAP/ALDH5A1/GCLC 3 GO:0000303 response to superoxide 1/147 28/18722 0.198183808483802 0.333765636922889 SOD2 1 GO:0001945 lymph vessel development 1/147 28/18722 0.198183808483802 0.333765636922889 VEGFA 1 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1/147 28/18722 0.198183808483802 0.333765636922889 HLA-F 1 GO:0007141 male meiosis I 1/147 28/18722 0.198183808483802 0.333765636922889 MOV10L1 1 GO:0009312 oligosaccharide biosynthetic process 1/147 28/18722 0.198183808483802 0.333765636922889 B4GALT1 1 GO:0010575 positive regulation of vascular endothelial growth factor production 1/147 28/18722 0.198183808483802 0.333765636922889 HIF1A 1 GO:0010884 positive regulation of lipid storage 1/147 28/18722 0.198183808483802 0.333765636922889 PLIN2 1 GO:0031342 negative regulation of cell killing 1/147 28/18722 0.198183808483802 0.333765636922889 HLA-F 1 GO:0032958 inositol phosphate biosynthetic process 1/147 28/18722 0.198183808483802 0.333765636922889 SNCA 1 GO:0034123 positive regulation of toll-like receptor signaling pathway 1/147 28/18722 0.198183808483802 0.333765636922889 SLC15A4 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/147 28/18722 0.198183808483802 0.333765636922889 VEGFA 1 GO:0045589 regulation of regulatory T cell differentiation 1/147 28/18722 0.198183808483802 0.333765636922889 SOCS1 1 GO:0050996 positive regulation of lipid catabolic process 1/147 28/18722 0.198183808483802 0.333765636922889 IRS2 1 GO:0060325 face morphogenesis 1/147 28/18722 0.198183808483802 0.333765636922889 DLX5 1 GO:1903649 regulation of cytoplasmic transport 1/147 28/18722 0.198183808483802 0.333765636922889 DAB2 1 GO:0016079 synaptic vesicle exocytosis 2/147 105/18722 0.199574136022347 0.335696630456387 SNCA/DNAJC5 2 GO:2001022 positive regulation of response to DNA damage stimulus 2/147 105/18722 0.199574136022347 0.335696630456387 PARP9/MYC 2 GO:0034470 ncRNA processing 5/147 395/18722 0.199747676219862 0.335696630456387 DUS1L/NOP14/YTHDF2/SMAD3/PIH1D1 5 GO:0045664 regulation of neuron differentiation 3/147 196/18722 0.199891574337287 0.335696630456387 SHH/CASZ1/DKK1 3 GO:0090276 regulation of peptide hormone secretion 3/147 196/18722 0.199891574337287 0.335696630456387 IRS2/GJA1/HIF1A 3 GO:0006766 vitamin metabolic process 2/147 106/18722 0.2024316893676 0.337728457093709 NNMT/GCLC 2 GO:0006906 vesicle fusion 2/147 106/18722 0.2024316893676 0.337728457093709 SNCA/SAMD9 2 GO:0019882 antigen processing and presentation 2/147 106/18722 0.2024316893676 0.337728457093709 HLA-F/CTSH 2 GO:0046620 regulation of organ growth 2/147 106/18722 0.2024316893676 0.337728457093709 STK4/GJA1 2 GO:0046822 regulation of nucleocytoplasmic transport 2/147 106/18722 0.2024316893676 0.337728457093709 SHH/SMAD3 2 GO:0071887 leukocyte apoptotic process 2/147 106/18722 0.2024316893676 0.337728457093709 IRS2/HIF1A 2 GO:0090263 positive regulation of canonical Wnt signaling pathway 2/147 106/18722 0.2024316893676 0.337728457093709 SMAD3/DLX5 2 GO:0051258 protein polymerization 4/147 296/18722 0.203897389964547 0.337728457093709 SNCA/HSPA1A/HSPA1B/CCDC57 4 GO:0031099 regeneration 3/147 198/18722 0.203917180124349 0.337728457093709 PTGFRN/NNMT/CEBPB 3 GO:0050864 regulation of B cell activation 3/147 198/18722 0.203917180124349 0.337728457093709 IGKC/SLC15A4/IRS2 3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 1/147 29/18722 0.20448887856794 0.337728457093709 TOB1 1 GO:0000305 response to oxygen radical 1/147 29/18722 0.20448887856794 0.337728457093709 SOD2 1 GO:0001916 positive regulation of T cell mediated cytotoxicity 1/147 29/18722 0.20448887856794 0.337728457093709 HLA-F 1 GO:0002360 T cell lineage commitment 1/147 29/18722 0.20448887856794 0.337728457093709 SHH 1 GO:0005979 regulation of glycogen biosynthetic process 1/147 29/18722 0.20448887856794 0.337728457093709 IRS2 1 GO:0010962 regulation of glucan biosynthetic process 1/147 29/18722 0.20448887856794 0.337728457093709 IRS2 1 GO:0019082 viral protein processing 1/147 29/18722 0.20448887856794 0.337728457093709 PARP9 1 GO:0021522 spinal cord motor neuron differentiation 1/147 29/18722 0.20448887856794 0.337728457093709 SHH 1 GO:0021591 ventricular system development 1/147 29/18722 0.20448887856794 0.337728457093709 TSKU 1 GO:0021772 olfactory bulb development 1/147 29/18722 0.20448887856794 0.337728457093709 DLX5 1 GO:0022011 myelination in peripheral nervous system 1/147 29/18722 0.20448887856794 0.337728457093709 NDRG1 1 GO:0031069 hair follicle morphogenesis 1/147 29/18722 0.20448887856794 0.337728457093709 SHH 1 GO:0032292 peripheral nervous system axon ensheathment 1/147 29/18722 0.20448887856794 0.337728457093709 NDRG1 1 GO:0032372 negative regulation of sterol transport 1/147 29/18722 0.20448887856794 0.337728457093709 SHH 1 GO:0032375 negative regulation of cholesterol transport 1/147 29/18722 0.20448887856794 0.337728457093709 SHH 1 GO:0034067 protein localization to Golgi apparatus 1/147 29/18722 0.20448887856794 0.337728457093709 VPS13A 1 GO:0051654 establishment of mitochondrion localization 1/147 29/18722 0.20448887856794 0.337728457093709 HIF1A 1 GO:0098868 bone growth 1/147 29/18722 0.20448887856794 0.337728457093709 TSKU 1 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1/147 29/18722 0.20448887856794 0.337728457093709 BDKRB2 1 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 1/147 29/18722 0.20448887856794 0.337728457093709 PARP9 1 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/147 107/18722 0.205293988051301 0.338124624593304 HLA-F/CD55 2 GO:0032526 response to retinoic acid 2/147 107/18722 0.205293988051301 0.338124624593304 CTSH/GJA1 2 GO:0042303 molting cycle 2/147 107/18722 0.205293988051301 0.338124624593304 SHH/TSKU 2 GO:0042633 hair cycle 2/147 107/18722 0.205293988051301 0.338124624593304 SHH/TSKU 2 GO:0051341 regulation of oxidoreductase activity 2/147 107/18722 0.205293988051301 0.338124624593304 SNCA/HIF1A 2 GO:0042098 T cell proliferation 3/147 199/18722 0.205937136803564 0.338997235101519 SHH/CD55/CEBPB 3 GO:0002791 regulation of peptide secretion 3/147 200/18722 0.207961737849062 0.341904944361466 IRS2/GJA1/HIF1A 3 GO:0002832 negative regulation of response to biotic stimulus 2/147 108/18722 0.208160783578144 0.341904944361466 HLA-F/YTHDF2 2 GO:0098659 inorganic cation import across plasma membrane 2/147 108/18722 0.208160783578144 0.341904944361466 SLC30A1/SLC39A14 2 GO:0099587 inorganic ion import across plasma membrane 2/147 108/18722 0.208160783578144 0.341904944361466 SLC30A1/SLC39A14 2 GO:0006403 RNA localization 3/147 201/18722 0.209990890078306 0.342388597540347 ALKBH5/RBM15B/PIH1D1 3 GO:0009952 anterior/posterior pattern specification 3/147 201/18722 0.209990890078306 0.342388597540347 SHH/SMAD3/HOXD8 3 GO:0000132 establishment of mitotic spindle orientation 1/147 30/18722 0.210744703467662 0.342388597540347 GJA1 1 GO:0003299 muscle hypertrophy in response to stress 1/147 30/18722 0.210744703467662 0.342388597540347 SMAD3 1 GO:0010453 regulation of cell fate commitment 1/147 30/18722 0.210744703467662 0.342388597540347 DKK1 1 GO:0014887 cardiac muscle adaptation 1/147 30/18722 0.210744703467662 0.342388597540347 SMAD3 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/147 30/18722 0.210744703467662 0.342388597540347 SMAD3 1 GO:0034694 response to prostaglandin 1/147 30/18722 0.210744703467662 0.342388597540347 PRKAA2 1 GO:0044030 regulation of DNA methylation 1/147 30/18722 0.210744703467662 0.342388597540347 MYC 1 GO:0045070 positive regulation of viral genome replication 1/147 30/18722 0.210744703467662 0.342388597540347 IFIT1 1 GO:0045940 positive regulation of steroid metabolic process 1/147 30/18722 0.210744703467662 0.342388597540347 PPARGC1A 1 GO:0048147 negative regulation of fibroblast proliferation 1/147 30/18722 0.210744703467662 0.342388597540347 MYC 1 GO:0060218 hematopoietic stem cell differentiation 1/147 30/18722 0.210744703467662 0.342388597540347 YTHDF2 1 GO:0060351 cartilage development involved in endochondral bone morphogenesis 1/147 30/18722 0.210744703467662 0.342388597540347 TSKU 1 GO:0060674 placenta blood vessel development 1/147 30/18722 0.210744703467662 0.342388597540347 SOCS3 1 GO:0061311 cell surface receptor signaling pathway involved in heart development 1/147 30/18722 0.210744703467662 0.342388597540347 DKK1 1 GO:0070168 negative regulation of biomineral tissue development 1/147 30/18722 0.210744703467662 0.342388597540347 HIF1A 1 GO:0140058 neuron projection arborization 1/147 30/18722 0.210744703467662 0.342388597540347 TPBG 1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 1/147 30/18722 0.210744703467662 0.342388597540347 PPP1R15A 1 GO:2000648 positive regulation of stem cell proliferation 1/147 30/18722 0.210744703467662 0.342388597540347 GJA1 1 GO:0032410 negative regulation of transporter activity 2/147 109/18722 0.211031831011645 0.342483020377553 SNCA/GEM 2 GO:0034766 negative regulation of ion transmembrane transport 2/147 109/18722 0.211031831011645 0.342483020377553 GEM/SLC30A1 2 GO:0090087 regulation of peptide transport 3/147 202/18722 0.212024500665088 0.343748466730826 IRS2/GJA1/HIF1A 3 GO:0030198 extracellular matrix organization 4/147 301/18722 0.212041431333459 0.343748466730826 B4GALT1/RXFP1/WDR72/SMAD3 4 GO:0043062 extracellular structure organization 4/147 302/18722 0.21368135670583 0.344826295921657 B4GALT1/RXFP1/WDR72/SMAD3 4 GO:0014812 muscle cell migration 2/147 110/18722 0.213906888934228 0.344826295921657 PPARGC1A/PLAT 2 GO:0090174 organelle membrane fusion 2/147 110/18722 0.213906888934228 0.344826295921657 SNCA/SAMD9 2 GO:0071383 cellular response to steroid hormone stimulus 3/147 204/18722 0.216104727425976 0.344826295921657 PMEPA1/PIAS2/DAB2 3 GO:0034655 nucleobase-containing compound catabolic process 5/147 407/18722 0.216439730562134 0.344826295921657 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0001938 positive regulation of endothelial cell proliferation 2/147 111/18722 0.216785719407709 0.344826295921657 VEGFA/HIF1A 2 GO:0071867 response to monoamine 2/147 111/18722 0.216785719407709 0.344826295921657 PPARGC1A/SNCA 2 GO:0071869 response to catecholamine 2/147 111/18722 0.216785719407709 0.344826295921657 PPARGC1A/SNCA 2 GO:0090288 negative regulation of cellular response to growth factor stimulus 2/147 111/18722 0.216785719407709 0.344826295921657 HTRA3/TOB1 2 GO:0001782 B cell homeostasis 1/147 31/18722 0.216951665194083 0.344826295921657 HIF1A 1 GO:0002063 chondrocyte development 1/147 31/18722 0.216951665194083 0.344826295921657 TSKU 1 GO:0002230 positive regulation of defense response to virus by host 1/147 31/18722 0.216951665194083 0.344826295921657 PARP9 1 GO:0002323 natural killer cell activation involved in immune response 1/147 31/18722 0.216951665194083 0.344826295921657 HLA-F 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/147 31/18722 0.216951665194083 0.344826295921657 HLA-F 1 GO:0006779 porphyrin-containing compound biosynthetic process 1/147 31/18722 0.216951665194083 0.344826295921657 ALAD 1 GO:0007190 activation of adenylate cyclase activity 1/147 31/18722 0.216951665194083 0.344826295921657 RXFP1 1 GO:0021988 olfactory lobe development 1/147 31/18722 0.216951665194083 0.344826295921657 DLX5 1 GO:0031063 regulation of histone deacetylation 1/147 31/18722 0.216951665194083 0.344826295921657 VEGFA 1 GO:0033014 tetrapyrrole biosynthetic process 1/147 31/18722 0.216951665194083 0.344826295921657 ALAD 1 GO:0035115 embryonic forelimb morphogenesis 1/147 31/18722 0.216951665194083 0.344826295921657 SHH 1 GO:0036475 neuron death in response to oxidative stress 1/147 31/18722 0.216951665194083 0.344826295921657 HIF1A 1 GO:0042133 neurotransmitter metabolic process 1/147 31/18722 0.216951665194083 0.344826295921657 ALDH5A1 1 GO:0043171 peptide catabolic process 1/147 31/18722 0.216951665194083 0.344826295921657 CTSH 1 GO:0045066 regulatory T cell differentiation 1/147 31/18722 0.216951665194083 0.344826295921657 SOCS1 1 GO:0048566 embryonic digestive tract development 1/147 31/18722 0.216951665194083 0.344826295921657 SHH 1 GO:0050482 arachidonic acid secretion 1/147 31/18722 0.216951665194083 0.344826295921657 BDKRB2 1 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1/147 31/18722 0.216951665194083 0.344826295921657 DCUN1D1 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/147 31/18722 0.216951665194083 0.344826295921657 GJA1 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/147 31/18722 0.216951665194083 0.344826295921657 DKK1 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/147 31/18722 0.216951665194083 0.344826295921657 SH3BP5 1 GO:0061117 negative regulation of heart growth 1/147 31/18722 0.216951665194083 0.344826295921657 GJA1 1 GO:0070528 protein kinase C signaling 1/147 31/18722 0.216951665194083 0.344826295921657 VEGFA 1 GO:0071168 protein localization to chromatin 1/147 31/18722 0.216951665194083 0.344826295921657 PIH1D1 1 GO:0110150 negative regulation of biomineralization 1/147 31/18722 0.216951665194083 0.344826295921657 HIF1A 1 GO:1901797 negative regulation of signal transduction by p53 class mediator 1/147 31/18722 0.216951665194083 0.344826295921657 BDKRB2 1 GO:1903963 arachidonate transport 1/147 31/18722 0.216951665194083 0.344826295921657 BDKRB2 1 GO:0045229 external encapsulating structure organization 4/147 304/18722 0.216971945477954 0.344826295921657 B4GALT1/RXFP1/WDR72/SMAD3 4 GO:0060348 bone development 3/147 205/18722 0.218151159785584 0.34651626071093 GJA1/TSKU/DLX5 3 GO:0002821 positive regulation of adaptive immune response 2/147 112/18722 0.219668087934186 0.348370758754586 HLA-F/CD55 2 GO:0009141 nucleoside triphosphate metabolic process 2/147 112/18722 0.219668087934186 0.348370758754586 PPARGC1A/AK4 2 GO:0048640 negative regulation of developmental growth 2/147 112/18722 0.219668087934186 0.348370758754586 STK4/GJA1 2 GO:0048863 stem cell differentiation 3/147 206/18722 0.2202016828856 0.348471246558898 SHH/YTHDF2/HIF1A 3 GO:0002708 positive regulation of lymphocyte mediated immunity 2/147 113/18722 0.222553763417305 0.348471246558898 HLA-F/CD55 2 GO:0044106 cellular amine metabolic process 2/147 113/18722 0.222553763417305 0.348471246558898 SNCA/NNMT 2 GO:0044344 cellular response to fibroblast growth factor stimulus 2/147 113/18722 0.222553763417305 0.348471246558898 SNCA/GCLC 2 GO:0071347 cellular response to interleukin-1 2/147 113/18722 0.222553763417305 0.348471246558898 HIF1A/CEBPB 2 GO:0006026 aminoglycan catabolic process 1/147 32/18722 0.223110142815209 0.348471246558898 IDS 1 GO:0007435 salivary gland morphogenesis 1/147 32/18722 0.223110142815209 0.348471246558898 SHH 1 GO:0010644 cell communication by electrical coupling 1/147 32/18722 0.223110142815209 0.348471246558898 GJA1 1 GO:0014044 Schwann cell development 1/147 32/18722 0.223110142815209 0.348471246558898 NDRG1 1 GO:0030431 sleep 1/147 32/18722 0.223110142815209 0.348471246558898 FOS 1 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 1/147 32/18722 0.223110142815209 0.348471246558898 DAB2 1 GO:0033687 osteoblast proliferation 1/147 32/18722 0.223110142815209 0.348471246558898 SMAD3 1 GO:0035456 response to interferon-beta 1/147 32/18722 0.223110142815209 0.348471246558898 PLSCR1 1 GO:0035767 endothelial cell chemotaxis 1/147 32/18722 0.223110142815209 0.348471246558898 VEGFA 1 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 1/147 32/18722 0.223110142815209 0.348471246558898 SOCS1 1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1/147 32/18722 0.223110142815209 0.348471246558898 HEXIM1 1 GO:0048841 regulation of axon extension involved in axon guidance 1/147 32/18722 0.223110142815209 0.348471246558898 VEGFA 1 GO:0050850 positive regulation of calcium-mediated signaling 1/147 32/18722 0.223110142815209 0.348471246558898 CHERP 1 GO:0060323 head morphogenesis 1/147 32/18722 0.223110142815209 0.348471246558898 DLX5 1 GO:0060914 heart formation 1/147 32/18722 0.223110142815209 0.348471246558898 DKK1 1 GO:0061036 positive regulation of cartilage development 1/147 32/18722 0.223110142815209 0.348471246558898 SMAD3 1 GO:0072337 modified amino acid transport 1/147 32/18722 0.223110142815209 0.348471246558898 GJA1 1 GO:0090140 regulation of mitochondrial fission 1/147 32/18722 0.223110142815209 0.348471246558898 PPARGC1A 1 GO:1901532 regulation of hematopoietic progenitor cell differentiation 1/147 32/18722 0.223110142815209 0.348471246558898 YTHDF2 1 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/147 32/18722 0.223110142815209 0.348471246558898 HSPA1A 1 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 1/147 32/18722 0.223110142815209 0.348471246558898 DAB2 1 GO:1905476 negative regulation of protein localization to membrane 1/147 32/18722 0.223110142815209 0.348471246558898 DAB2 1 GO:2000191 regulation of fatty acid transport 1/147 32/18722 0.223110142815209 0.348471246558898 IRS2 1 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 1/147 32/18722 0.223110142815209 0.348471246558898 CBFB 1 GO:0002440 production of molecular mediator of immune response 4/147 308/18722 0.223594749890183 0.348863795994542 IGKC/SLC15A4/HLA-F/CD55 4 GO:0006909 phagocytosis 4/147 308/18722 0.223594749890183 0.348863795994542 IGKC/PLSCR1/SRPX/C4BPA 4 GO:0006836 neurotransmitter transport 3/147 208/18722 0.2243146378881 0.349804526550212 SNCA/SLC30A1/DNAJC5 3 GO:0002244 hematopoietic progenitor cell differentiation 2/147 114/18722 0.225442518123936 0.351014352789533 SHH/YTHDF2 2 GO:0022904 respiratory electron transport chain 2/147 114/18722 0.225442518123936 0.351014352789533 PPARGC1A/SNCA 2 GO:0046660 female sex differentiation 2/147 114/18722 0.225442518123936 0.351014352789533 VEGFA/CEBPB 2 GO:0071222 cellular response to lipopolysaccharide 3/147 209/18722 0.226376889066475 0.352102587206358 PPARGC1A/CD55/CEBPB 3 GO:1902905 positive regulation of supramolecular fiber organization 3/147 209/18722 0.226376889066475 0.352102587206358 HSPA1A/HSPA1B/SMAD3 3 GO:0032409 regulation of transporter activity 4/147 310/18722 0.226926209250233 0.352773540471647 PPARGC1A/SNCA/GEM/GJA1 4 GO:0034968 histone lysine methylation 2/147 115/18722 0.228334127646213 0.353037359847103 NNMT/PIH1D1 2 GO:0043279 response to alkaloid 2/147 115/18722 0.228334127646213 0.353037359847103 PPARGC1A/SNCA 2 GO:0051209 release of sequestered calcium ion into cytosol 2/147 115/18722 0.228334127646213 0.353037359847103 SNCA/CHERP 2 GO:0001881 receptor recycling 1/147 33/18722 0.22922051247846 0.353037359847103 SNCA 1 GO:0002431 Fc receptor mediated stimulatory signaling pathway 1/147 33/18722 0.22922051247846 0.353037359847103 PLSCR1 1 GO:0010259 multicellular organism aging 1/147 33/18722 0.22922051247846 0.353037359847103 TFCP2L1 1 GO:0010984 regulation of lipoprotein particle clearance 1/147 33/18722 0.22922051247846 0.353037359847103 CNPY2 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/147 33/18722 0.22922051247846 0.353037359847103 HIF1A 1 GO:0032633 interleukin-4 production 1/147 33/18722 0.22922051247846 0.353037359847103 CEBPB 1 GO:0032673 regulation of interleukin-4 production 1/147 33/18722 0.22922051247846 0.353037359847103 CEBPB 1 GO:0048730 epidermis morphogenesis 1/147 33/18722 0.22922051247846 0.353037359847103 SHH 1 GO:0060122 inner ear receptor cell stereocilium organization 1/147 33/18722 0.22922051247846 0.353037359847103 TSKU 1 GO:0071353 cellular response to interleukin-4 1/147 33/18722 0.22922051247846 0.353037359847103 ALAD 1 GO:0110110 positive regulation of animal organ morphogenesis 1/147 33/18722 0.22922051247846 0.353037359847103 DKK1 1 GO:1902275 regulation of chromatin organization 1/147 33/18722 0.22922051247846 0.353037359847103 TLK1 1 GO:1903146 regulation of autophagy of mitochondrion 1/147 33/18722 0.22922051247846 0.353037359847103 HIF1A 1 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 1/147 33/18722 0.22922051247846 0.353037359847103 HEXIM1 1 GO:2000036 regulation of stem cell population maintenance 1/147 33/18722 0.22922051247846 0.353037359847103 MYC 1 GO:0070588 calcium ion transmembrane transport 4/147 312/18722 0.230270536800977 0.354297460187922 SNCA/GEM/CHERP/TRPC4 4 GO:0042180 cellular ketone metabolic process 3/147 211/18722 0.230512489978501 0.354297460187922 PPARGC1A/SNCA/IRS2 3 GO:0046474 glycerophospholipid biosynthetic process 3/147 211/18722 0.230512489978501 0.354297460187922 SOCS1/PLSCR1/SOCS3 3 GO:0050807 regulation of synapse organization 3/147 211/18722 0.230512489978501 0.354297460187922 SNCA/SLITRK4/TPBG 3 GO:0021782 glial cell development 2/147 116/18722 0.231228370863976 0.354486959125655 SHH/NDRG1 2 GO:0030326 embryonic limb morphogenesis 2/147 116/18722 0.231228370863976 0.354486959125655 SHH/DLX5 2 GO:0035113 embryonic appendage morphogenesis 2/147 116/18722 0.231228370863976 0.354486959125655 SHH/DLX5 2 GO:0051283 negative regulation of sequestering of calcium ion 2/147 116/18722 0.231228370863976 0.354486959125655 SNCA/CHERP 2 GO:1990748 cellular detoxification 2/147 116/18722 0.231228370863976 0.354486959125655 HBG1/SOD2 2 GO:0006457 protein folding 3/147 212/18722 0.232585661418432 0.356202618178458 HSPA1A/DNAJC5/HSPA1B 3 GO:0030258 lipid modification 3/147 212/18722 0.232585661418432 0.356202618178458 PPARGC1A/MCAT/IRS2 3 GO:0002702 positive regulation of production of molecular mediator of immune response 2/147 117/18722 0.234125029907578 0.357043071523159 HLA-F/CD55 2 GO:0030301 cholesterol transport 2/147 117/18722 0.234125029907578 0.357043071523159 SHH/TSKU 2 GO:0051225 spindle assembly 2/147 117/18722 0.234125029907578 0.357043071523159 HSPA1A/HSPA1B 2 GO:0043583 ear development 3/147 213/18722 0.234662295344274 0.357043071523159 SHH/TSKU/DLX5 3 GO:0001662 behavioral fear response 1/147 34/18722 0.235283147433015 0.357043071523159 GJA1 1 GO:0002183 cytoplasmic translational initiation 1/147 34/18722 0.235283147433015 0.357043071523159 YTHDF2 1 GO:0006356 regulation of transcription by RNA polymerase I 1/147 34/18722 0.235283147433015 0.357043071523159 PIH1D1 1 GO:0009303 rRNA transcription 1/147 34/18722 0.235283147433015 0.357043071523159 PIH1D1 1 GO:0010614 negative regulation of cardiac muscle hypertrophy 1/147 34/18722 0.235283147433015 0.357043071523159 SMAD3 1 GO:0031128 developmental induction 1/147 34/18722 0.235283147433015 0.357043071523159 DKK1 1 GO:0032212 positive regulation of telomere maintenance via telomerase 1/147 34/18722 0.235283147433015 0.357043071523159 MAP3K4 1 GO:0032770 positive regulation of monooxygenase activity 1/147 34/18722 0.235283147433015 0.357043071523159 HIF1A 1 GO:0034383 low-density lipoprotein particle clearance 1/147 34/18722 0.235283147433015 0.357043071523159 CNPY2 1 GO:0035137 hindlimb morphogenesis 1/147 34/18722 0.235283147433015 0.357043071523159 SHH 1 GO:0035308 negative regulation of protein dephosphorylation 1/147 34/18722 0.235283147433015 0.357043071523159 PPP1R15A 1 GO:0070232 regulation of T cell apoptotic process 1/147 34/18722 0.235283147433015 0.357043071523159 HIF1A 1 GO:0070884 regulation of calcineurin-NFAT signaling cascade 1/147 34/18722 0.235283147433015 0.357043071523159 CHERP 1 GO:0086019 cell-cell signaling involved in cardiac conduction 1/147 34/18722 0.235283147433015 0.357043071523159 GJA1 1 GO:0044242 cellular lipid catabolic process 3/147 214/18722 0.236742303654884 0.35804972492531 MCAT/LPIN3/IRS2 3 GO:0006413 translational initiation 2/147 118/18722 0.237023890121068 0.35804972492531 PPP1R15A/YTHDF2 2 GO:0007613 memory 2/147 118/18722 0.237023890121068 0.35804972492531 ATAD1/CEBPB 2 GO:0009308 amine metabolic process 2/147 118/18722 0.237023890121068 0.35804972492531 SNCA/NNMT 2 GO:0022612 gland morphogenesis 2/147 118/18722 0.237023890121068 0.35804972492531 SHH/CEBPB 2 GO:0045446 endothelial cell differentiation 2/147 118/18722 0.237023890121068 0.35804972492531 ATOH8/VEGFA 2 GO:0051282 regulation of sequestering of calcium ion 2/147 118/18722 0.237023890121068 0.35804972492531 SNCA/CHERP 2 GO:0071346 cellular response to interferon-gamma 2/147 118/18722 0.237023890121068 0.35804972492531 SOCS1/PARP9 2 GO:1903313 positive regulation of mRNA metabolic process 2/147 118/18722 0.237023890121068 0.35804972492531 TOB1/YTHDF2 2 GO:0030282 bone mineralization 2/147 119/18722 0.239924740025755 0.360141501194357 SMAD3/HIF1A 2 GO:0070661 leukocyte proliferation 4/147 318/18722 0.240376967097167 0.360141501194357 SHH/IRS2/CD55/CEBPB 4 GO:0009612 response to mechanical stimulus 3/147 216/18722 0.240912093162909 0.360141501194357 FOS/GJA1/GCLC 3 GO:0000460 maturation of 5.8S rRNA 1/147 35/18722 0.241298418051987 0.360141501194357 NOP14 1 GO:0001893 maternal placenta development 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0002209 behavioral defense response 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0006471 protein ADP-ribosylation 1/147 35/18722 0.241298418051987 0.360141501194357 PARP9 1 GO:0009119 ribonucleoside metabolic process 1/147 35/18722 0.241298418051987 0.360141501194357 MTAP 1 GO:0021955 central nervous system neuron axonogenesis 1/147 35/18722 0.241298418051987 0.360141501194357 TSKU 1 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1/147 35/18722 0.241298418051987 0.360141501194357 SHH 1 GO:0032814 regulation of natural killer cell activation 1/147 35/18722 0.241298418051987 0.360141501194357 HLA-F 1 GO:0034405 response to fluid shear stress 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0040001 establishment of mitotic spindle localization 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0042462 eye photoreceptor cell development 1/147 35/18722 0.241298418051987 0.360141501194357 VEGFA 1 GO:0045454 cell redox homeostasis 1/147 35/18722 0.241298418051987 0.360141501194357 GCLC 1 GO:0045880 positive regulation of smoothened signaling pathway 1/147 35/18722 0.241298418051987 0.360141501194357 SHH 1 GO:0045907 positive regulation of vasoconstriction 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0046640 regulation of alpha-beta T cell proliferation 1/147 35/18722 0.241298418051987 0.360141501194357 CD55 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/147 35/18722 0.241298418051987 0.360141501194357 VEGFA 1 GO:0097421 liver regeneration 1/147 35/18722 0.241298418051987 0.360141501194357 CEBPB 1 GO:0098801 regulation of renal system process 1/147 35/18722 0.241298418051987 0.360141501194357 GJA1 1 GO:0098810 neurotransmitter reuptake 1/147 35/18722 0.241298418051987 0.360141501194357 SNCA 1 GO:0106056 regulation of calcineurin-mediated signaling 1/147 35/18722 0.241298418051987 0.360141501194357 CHERP 1 GO:1905207 regulation of cardiocyte differentiation 1/147 35/18722 0.241298418051987 0.360141501194357 DKK1 1 GO:0008202 steroid metabolic process 4/147 319/18722 0.242071591164299 0.361115276395221 PPARGC1A/SHH/PRKAA2/TSKU 4 GO:0007052 mitotic spindle organization 2/147 120/18722 0.24282737128413 0.36188174763868 HSPA1A/HSPA1B 2 GO:0071774 response to fibroblast growth factor 2/147 120/18722 0.24282737128413 0.36188174763868 SNCA/GCLC 2 GO:0007596 blood coagulation 3/147 217/18722 0.243001700308098 0.361961198018685 PLSCR1/SHH/PLAT 3 GO:0050808 synapse organization 5/147 426/18722 0.243717624247998 0.362562461503641 SNCA/SLITRK4/TPBG/NDRG1/DKK1 5 GO:0009416 response to light stimulus 4/147 320/18722 0.243769010392451 0.362562461503641 FOS/MAP3K4/MYC/HIF1A 4 GO:0071496 cellular response to external stimulus 4/147 320/18722 0.243769010392451 0.362562461503641 PRKAA2/FOS/GJA1/GCLC 4 GO:0042445 hormone metabolic process 3/147 218/18722 0.245094333741938 0.363070532811299 PPARGC1A/SHH/HIF1A 3 GO:0050803 regulation of synapse structure or activity 3/147 218/18722 0.245094333741938 0.363070532811299 SNCA/SLITRK4/TPBG 3 GO:0001838 embryonic epithelial tube formation 2/147 121/18722 0.245731578664152 0.363070532811299 STK4/HIF1A 2 GO:0042752 regulation of circadian rhythm 2/147 121/18722 0.245731578664152 0.363070532811299 PPARGC1A/PRKAA2 2 GO:0043500 muscle adaptation 2/147 121/18722 0.245731578664152 0.363070532811299 PPARGC1A/SMAD3 2 GO:0048706 embryonic skeletal system development 2/147 121/18722 0.245731578664152 0.363070532811299 SHH/SMAD3 2 GO:1904019 epithelial cell apoptotic process 2/147 121/18722 0.245731578664152 0.363070532811299 PPARGC1A/STK4 2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste 1/147 36/18722 0.247266691854435 0.363070532811299 CST2 1 GO:0008207 C21-steroid hormone metabolic process 1/147 36/18722 0.247266691854435 0.363070532811299 PPARGC1A 1 GO:0010092 specification of animal organ identity 1/147 36/18722 0.247266691854435 0.363070532811299 DKK1 1 GO:0010923 negative regulation of phosphatase activity 1/147 36/18722 0.247266691854435 0.363070532811299 PPP1R15A 1 GO:0014046 dopamine secretion 1/147 36/18722 0.247266691854435 0.363070532811299 SNCA 1 GO:0014059 regulation of dopamine secretion 1/147 36/18722 0.247266691854435 0.363070532811299 SNCA 1 GO:0014741 negative regulation of muscle hypertrophy 1/147 36/18722 0.247266691854435 0.363070532811299 SMAD3 1 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 1/147 36/18722 0.247266691854435 0.363070532811299 HIF1A 1 GO:0044060 regulation of endocrine process 1/147 36/18722 0.247266691854435 0.363070532811299 GJA1 1 GO:0045191 regulation of isotype switching 1/147 36/18722 0.247266691854435 0.363070532811299 SLC15A4 1 GO:0045746 negative regulation of Notch signaling pathway 1/147 36/18722 0.247266691854435 0.363070532811299 YTHDF2 1 GO:0051354 negative regulation of oxidoreductase activity 1/147 36/18722 0.247266691854435 0.363070532811299 SNCA 1 GO:0051385 response to mineralocorticoid 1/147 36/18722 0.247266691854435 0.363070532811299 FOS 1 GO:0051955 regulation of amino acid transport 1/147 36/18722 0.247266691854435 0.363070532811299 SNCA 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/147 36/18722 0.247266691854435 0.363070532811299 YTHDF2 1 GO:0070306 lens fiber cell differentiation 1/147 36/18722 0.247266691854435 0.363070532811299 SMAD3 1 GO:0070670 response to interleukin-4 1/147 36/18722 0.247266691854435 0.363070532811299 ALAD 1 GO:0070873 regulation of glycogen metabolic process 1/147 36/18722 0.247266691854435 0.363070532811299 IRS2 1 GO:0070897 transcription preinitiation complex assembly 1/147 36/18722 0.247266691854435 0.363070532811299 PIH1D1 1 GO:0051208 sequestering of calcium ion 2/147 122/18722 0.248637160003905 0.36490370243949 SNCA/CHERP 2 GO:0031503 protein-containing complex localization 3/147 220/18722 0.249288336218371 0.365679947831852 IFT46/ALKBH5/RBM15B 3 GO:0071219 cellular response to molecule of bacterial origin 3/147 221/18722 0.25138953475373 0.367971965782252 PPARGC1A/CD55/CEBPB 3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/147 37/18722 0.253188333527206 0.367971965782252 NOP14 1 GO:0003161 cardiac conduction system development 1/147 37/18722 0.253188333527206 0.367971965782252 GJA1 1 GO:0006623 protein targeting to vacuole 1/147 37/18722 0.253188333527206 0.367971965782252 VPS13A 1 GO:0007340 acrosome reaction 1/147 37/18722 0.253188333527206 0.367971965782252 B4GALT1 1 GO:0021532 neural tube patterning 1/147 37/18722 0.253188333527206 0.367971965782252 SHH 1 GO:0032570 response to progesterone 1/147 37/18722 0.253188333527206 0.367971965782252 FOS 1 GO:0032885 regulation of polysaccharide biosynthetic process 1/147 37/18722 0.253188333527206 0.367971965782252 IRS2 1 GO:0033120 positive regulation of RNA splicing 1/147 37/18722 0.253188333527206 0.367971965782252 HSPA1A 1 GO:0043368 positive T cell selection 1/147 37/18722 0.253188333527206 0.367971965782252 SHH 1 GO:0043403 skeletal muscle tissue regeneration 1/147 37/18722 0.253188333527206 0.367971965782252 PTGFRN 1 GO:0045730 respiratory burst 1/147 37/18722 0.253188333527206 0.367971965782252 CD55 1 GO:0048846 axon extension involved in axon guidance 1/147 37/18722 0.253188333527206 0.367971965782252 VEGFA 1 GO:0051294 establishment of spindle orientation 1/147 37/18722 0.253188333527206 0.367971965782252 GJA1 1 GO:0051567 histone H3-K9 methylation 1/147 37/18722 0.253188333527206 0.367971965782252 PIH1D1 1 GO:0060416 response to growth hormone 1/147 37/18722 0.253188333527206 0.367971965782252 GH2 1 GO:0060428 lung epithelium development 1/147 37/18722 0.253188333527206 0.367971965782252 SHH 1 GO:1902284 neuron projection extension involved in neuron projection guidance 1/147 37/18722 0.253188333527206 0.367971965782252 VEGFA 1 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 1/147 37/18722 0.253188333527206 0.367971965782252 MAP3K4 1 GO:0007599 hemostasis 3/147 222/18722 0.253493418570575 0.368057677157567 PLSCR1/SHH/PLAT 3 GO:0050817 coagulation 3/147 222/18722 0.253493418570575 0.368057677157567 PLSCR1/SHH/PLAT 3 GO:0001909 leukocyte mediated cytotoxicity 2/147 124/18722 0.254451651055939 0.368911724822256 HLA-F/CTSH 2 GO:0010508 positive regulation of autophagy 2/147 124/18722 0.254451651055939 0.368911724822256 PRKAA2/HIF1A 2 GO:0097237 cellular response to toxic substance 2/147 124/18722 0.254451651055939 0.368911724822256 HBG1/SOD2 2 GO:0002274 myeloid leukocyte activation 3/147 223/18722 0.255599903552866 0.370217584274393 PLSCR1/SNCA/NDRG1 3 GO:0050920 regulation of chemotaxis 3/147 223/18722 0.255599903552866 0.370217584274393 TPBG/VEGFA/SMAD3 3 GO:0007517 muscle organ development 4/147 327/18722 0.255725308859595 0.370219941335454 SHH/FOS/MAFF/SMAD3 4 GO:0055007 cardiac muscle cell differentiation 2/147 125/18722 0.25736017148183 0.372406518094898 VEGFA/DKK1 2 GO:0000578 embryonic axis specification 1/147 38/18722 0.259063704946607 0.373066702693934 HOXD8 1 GO:0002478 antigen processing and presentation of exogenous peptide antigen 1/147 38/18722 0.259063704946607 0.373066702693934 HLA-F 1 GO:0009595 detection of biotic stimulus 1/147 38/18722 0.259063704946607 0.373066702693934 SRPX 1 GO:0035136 forelimb morphogenesis 1/147 38/18722 0.259063704946607 0.373066702693934 SHH 1 GO:0042596 fear response 1/147 38/18722 0.259063704946607 0.373066702693934 GJA1 1 GO:0046633 alpha-beta T cell proliferation 1/147 38/18722 0.259063704946607 0.373066702693934 CD55 1 GO:0048713 regulation of oligodendrocyte differentiation 1/147 38/18722 0.259063704946607 0.373066702693934 SHH 1 GO:0071392 cellular response to estradiol stimulus 1/147 38/18722 0.259063704946607 0.373066702693934 PPARGC1A 1 GO:0071398 cellular response to fatty acid 1/147 38/18722 0.259063704946607 0.373066702693934 PPARGC1A 1 GO:2000279 negative regulation of DNA biosynthetic process 1/147 38/18722 0.259063704946607 0.373066702693934 GJA1 1 GO:0006364 rRNA processing 3/147 225/18722 0.259820342858702 0.373257754798453 NOP14/YTHDF2/PIH1D1 3 GO:0008037 cell recognition 3/147 225/18722 0.259820342858702 0.373257754798453 IGKC/B4GALT1/C4BPA 3 GO:0010001 glial cell differentiation 3/147 225/18722 0.259820342858702 0.373257754798453 SHH/NDRG1/TRPC4 3 GO:0016485 protein processing 3/147 225/18722 0.259820342858702 0.373257754798453 SHH/CTSH/PLAT 3 GO:0050769 positive regulation of neurogenesis 3/147 225/18722 0.259820342858702 0.373257754798453 SHH/VEGFA/HIF1A 3 GO:0051495 positive regulation of cytoskeleton organization 3/147 226/18722 0.261934131268796 0.37611377178347 HSPA1A/HSPA1B/SMAD3 3 GO:0003002 regionalization 4/147 331/18722 0.262611845689165 0.376544597534177 SHH/SMAD3/HOXD8/DKK1 4 GO:0071214 cellular response to abiotic stimulus 4/147 331/18722 0.262611845689165 0.376544597534177 BDKRB2/GJA1/MYC/GCLC 4 GO:0104004 cellular response to environmental stimulus 4/147 331/18722 0.262611845689165 0.376544597534177 BDKRB2/GJA1/MYC/GCLC 4 GO:0035270 endocrine system development 2/147 127/18722 0.263178810960615 0.377176724285194 SHH/SMAD3 2 GO:0001914 regulation of T cell mediated cytotoxicity 1/147 39/18722 0.264893165199917 0.378183989075394 HLA-F 1 GO:0002701 negative regulation of production of molecular mediator of immune response 1/147 39/18722 0.264893165199917 0.378183989075394 HLA-F 1 GO:0016233 telomere capping 1/147 39/18722 0.264893165199917 0.378183989075394 MAP3K4 1 GO:0016572 histone phosphorylation 1/147 39/18722 0.264893165199917 0.378183989075394 PRKAA2 1 GO:0042417 dopamine metabolic process 1/147 39/18722 0.264893165199917 0.378183989075394 SNCA 1 GO:0046326 positive regulation of glucose import 1/147 39/18722 0.264893165199917 0.378183989075394 IRS2 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/147 39/18722 0.264893165199917 0.378183989075394 DKK1 1 GO:1902742 apoptotic process involved in development 1/147 39/18722 0.264893165199917 0.378183989075394 PPP2R1B 1 GO:1990778 protein localization to cell periphery 4/147 333/18722 0.266068749333807 0.378805748518712 TPBG/EPB41L3/WDR72/DAB2 4 GO:0001952 regulation of cell-matrix adhesion 2/147 128/18722 0.2660885582206 0.378805748518712 VEGFA/SMAD3 2 GO:0033865 nucleoside bisphosphate metabolic process 2/147 128/18722 0.2660885582206 0.378805748518712 SNCA/SLC35B2 2 GO:0033875 ribonucleoside bisphosphate metabolic process 2/147 128/18722 0.2660885582206 0.378805748518712 SNCA/SLC35B2 2 GO:0034032 purine nucleoside bisphosphate metabolic process 2/147 128/18722 0.2660885582206 0.378805748518712 SNCA/SLC35B2 2 GO:0035303 regulation of dephosphorylation 2/147 128/18722 0.2660885582206 0.378805748518712 PPP1R15A/SMAD3 2 GO:0042113 B cell activation 4/147 334/18722 0.26780045072873 0.381061440594496 IGKC/SLC15A4/IRS2/TPD52 4 GO:0033157 regulation of intracellular protein transport 3/147 229/18722 0.26828878592656 0.381393421438375 SHH/ZFAND1/SMAD3 3 GO:0071356 cellular response to tumor necrosis factor 3/147 229/18722 0.26828878592656 0.381393421438375 PPARGC1A/HSPA1A/HSPA1B 3 GO:0006638 neutral lipid metabolic process 2/147 129/18722 0.268998347375144 0.38152456087877 SNCA/LPIN3 2 GO:0045055 regulated exocytosis 3/147 230/18722 0.270411162947672 0.38152456087877 SNCA/DNAJC5/HLA-F 3 GO:0006730 one-carbon metabolic process 1/147 40/18722 0.270677070606737 0.38152456087877 CA12 1 GO:0007339 binding of sperm to zona pellucida 1/147 40/18722 0.270677070606737 0.38152456087877 B4GALT1 1 GO:0009069 serine family amino acid metabolic process 1/147 40/18722 0.270677070606737 0.38152456087877 GCLC 1 GO:0014037 Schwann cell differentiation 1/147 40/18722 0.270677070606737 0.38152456087877 NDRG1 1 GO:0030501 positive regulation of bone mineralization 1/147 40/18722 0.270677070606737 0.38152456087877 SMAD3 1 GO:0030866 cortical actin cytoskeleton organization 1/147 40/18722 0.270677070606737 0.38152456087877 EPB41L3 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization 1/147 40/18722 0.270677070606737 0.38152456087877 SNCA 1 GO:0035329 hippo signaling 1/147 40/18722 0.270677070606737 0.38152456087877 STK4 1 GO:0042073 intraciliary transport 1/147 40/18722 0.270677070606737 0.38152456087877 IFT46 1 GO:0045022 early endosome to late endosome transport 1/147 40/18722 0.270677070606737 0.38152456087877 DAB2 1 GO:0045429 positive regulation of nitric oxide biosynthetic process 1/147 40/18722 0.270677070606737 0.38152456087877 SMAD3 1 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 1/147 40/18722 0.270677070606737 0.38152456087877 SNCA 1 GO:0055081 anion homeostasis 1/147 40/18722 0.270677070606737 0.38152456087877 CA12 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/147 40/18722 0.270677070606737 0.38152456087877 GEM 1 GO:1901998 toxin transport 1/147 40/18722 0.270677070606737 0.38152456087877 COPB2 1 GO:2000781 positive regulation of double-strand break repair 1/147 40/18722 0.270677070606737 0.38152456087877 PARP9 1 GO:0046700 heterocycle catabolic process 5/147 445/18722 0.271861298055052 0.382538488608843 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0015918 sterol transport 2/147 130/18722 0.271907999592912 0.382538488608843 SHH/TSKU 2 GO:0042476 odontogenesis 2/147 130/18722 0.271907999592912 0.382538488608843 SHH/WDR72 2 GO:0051028 mRNA transport 2/147 130/18722 0.271907999592912 0.382538488608843 ALKBH5/RBM15B 2 GO:0032386 regulation of intracellular transport 4/147 337/18722 0.273008010492345 0.383905481609123 SHH/ZFAND1/SMAD3/DAB2 4 GO:0010594 regulation of endothelial cell migration 3/147 232/18722 0.274661672417192 0.385543461717347 ATOH8/VEGFA/HIF1A 3 GO:0032271 regulation of protein polymerization 3/147 232/18722 0.274661672417192 0.385543461717347 SNCA/HSPA1A/HSPA1B 3 GO:0000723 telomere maintenance 2/147 131/18722 0.274817338810225 0.385543461717347 MAP3K4/MYC 2 GO:0006661 phosphatidylinositol biosynthetic process 2/147 131/18722 0.274817338810225 0.385543461717347 SOCS1/SOCS3 2 GO:0018022 peptidyl-lysine methylation 2/147 131/18722 0.274817338810225 0.385543461717347 NNMT/PIH1D1 2 GO:0007099 centriole replication 1/147 41/18722 0.276415774740171 0.386078680283345 CCDC57 1 GO:0009167 purine ribonucleoside monophosphate metabolic process 1/147 41/18722 0.276415774740171 0.386078680283345 AK4 1 GO:0050691 regulation of defense response to virus by host 1/147 41/18722 0.276415774740171 0.386078680283345 PARP9 1 GO:0050913 sensory perception of bitter taste 1/147 41/18722 0.276415774740171 0.386078680283345 CST2 1 GO:0060612 adipose tissue development 1/147 41/18722 0.276415774740171 0.386078680283345 PPARGC1A 1 GO:0071470 cellular response to osmotic stress 1/147 41/18722 0.276415774740171 0.386078680283345 BDKRB2 1 GO:1901385 regulation of voltage-gated calcium channel activity 1/147 41/18722 0.276415774740171 0.386078680283345 GEM 1 GO:1904407 positive regulation of nitric oxide metabolic process 1/147 41/18722 0.276415774740171 0.386078680283345 SMAD3 1 GO:0002697 regulation of immune effector process 4/147 339/18722 0.276489646662295 0.386078680283345 SLC15A4/HLA-F/CD55/C4BPA 4 GO:0006790 sulfur compound metabolic process 4/147 339/18722 0.276489646662295 0.386078680283345 SNCA/MTAP/SLC35B2/GCLC 4 GO:0072175 epithelial tube formation 2/147 132/18722 0.277726191699149 0.387624376748555 STK4/HIF1A 2 GO:0044270 cellular nitrogen compound catabolic process 5/147 451/18722 0.280896614890206 0.390282099300428 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0045765 regulation of angiogenesis 4/147 342/18722 0.281726100768901 0.390282099300428 CTSH/VEGFA/PKM/HIF1A 4 GO:0000266 mitochondrial fission 1/147 42/18722 0.282109628447852 0.390282099300428 PPARGC1A 1 GO:0010677 negative regulation of cellular carbohydrate metabolic process 1/147 42/18722 0.282109628447852 0.390282099300428 PPARGC1A 1 GO:0014003 oligodendrocyte development 1/147 42/18722 0.282109628447852 0.390282099300428 SHH 1 GO:0014912 negative regulation of smooth muscle cell migration 1/147 42/18722 0.282109628447852 0.390282099300428 PPARGC1A 1 GO:0019432 triglyceride biosynthetic process 1/147 42/18722 0.282109628447852 0.390282099300428 LPIN3 1 GO:0030890 positive regulation of B cell proliferation 1/147 42/18722 0.282109628447852 0.390282099300428 IRS2 1 GO:0033003 regulation of mast cell activation 1/147 42/18722 0.282109628447852 0.390282099300428 PLSCR1 1 GO:0033574 response to testosterone 1/147 42/18722 0.282109628447852 0.390282099300428 MTAP 1 GO:0035019 somatic stem cell population maintenance 1/147 42/18722 0.282109628447852 0.390282099300428 MYC 1 GO:0042168 heme metabolic process 1/147 42/18722 0.282109628447852 0.390282099300428 ALAD 1 GO:0045687 positive regulation of glial cell differentiation 1/147 42/18722 0.282109628447852 0.390282099300428 SHH 1 GO:0045773 positive regulation of axon extension 1/147 42/18722 0.282109628447852 0.390282099300428 VEGFA 1 GO:0048489 synaptic vesicle transport 1/147 42/18722 0.282109628447852 0.390282099300428 SNCA 1 GO:0050912 detection of chemical stimulus involved in sensory perception of taste 1/147 42/18722 0.282109628447852 0.390282099300428 CST2 1 GO:0071312 cellular response to alkaloid 1/147 42/18722 0.282109628447852 0.390282099300428 PPARGC1A 1 GO:0072595 maintenance of protein localization in organelle 1/147 42/18722 0.282109628447852 0.390282099300428 GJA1 1 GO:1904037 positive regulation of epithelial cell apoptotic process 1/147 42/18722 0.282109628447852 0.390282099300428 PPARGC1A 1 GO:0003012 muscle system process 5/147 452/18722 0.282408521229954 0.390514973184833 BDKRB2/PPARGC1A/MYOF/GJA1/SMAD3 5 GO:0016072 rRNA metabolic process 3/147 236/18722 0.283183494070842 0.390817235106219 NOP14/YTHDF2/PIH1D1 3 GO:0030072 peptide hormone secretion 3/147 236/18722 0.283183494070842 0.390817235106219 IRS2/GJA1/HIF1A 3 GO:0048738 cardiac muscle tissue development 3/147 236/18722 0.283183494070842 0.390817235106219 VEGFA/GJA1/DKK1 3 GO:0002705 positive regulation of leukocyte mediated immunity 2/147 134/18722 0.283541758669507 0.390817235106219 HLA-F/CD55 2 GO:0008277 regulation of G protein-coupled receptor signaling pathway 2/147 134/18722 0.283541758669507 0.390817235106219 SNCA/SLC39A14 2 GO:0032147 activation of protein kinase activity 2/147 134/18722 0.283541758669507 0.390817235106219 SOCS1/VEGFA 2 GO:0042552 myelination 2/147 134/18722 0.283541758669507 0.390817235106219 NDRG1/EPB41L3 2 GO:0030336 negative regulation of cell migration 4/147 344/18722 0.285225885135211 0.392957449304199 PPARGC1A/SHH/MCC/GJA1 4 GO:0001504 neurotransmitter uptake 1/147 43/18722 0.287758979872807 0.394087504029105 SNCA 1 GO:0009268 response to pH 1/147 43/18722 0.287758979872807 0.394087504029105 GJA1 1 GO:0010171 body morphogenesis 1/147 43/18722 0.287758979872807 0.394087504029105 DLX5 1 GO:0016266 O-glycan processing 1/147 43/18722 0.287758979872807 0.394087504029105 GALNT15 1 GO:0031952 regulation of protein autophosphorylation 1/147 43/18722 0.287758979872807 0.394087504029105 VEGFA 1 GO:0033173 calcineurin-NFAT signaling cascade 1/147 43/18722 0.287758979872807 0.394087504029105 CHERP 1 GO:0042181 ketone biosynthetic process 1/147 43/18722 0.287758979872807 0.394087504029105 PPARGC1A 1 GO:0045776 negative regulation of blood pressure 1/147 43/18722 0.287758979872807 0.394087504029105 SOD2 1 GO:0046717 acid secretion 1/147 43/18722 0.287758979872807 0.394087504029105 TRPC4 1 GO:0098927 vesicle-mediated transport between endosomal compartments 1/147 43/18722 0.287758979872807 0.394087504029105 DAB2 1 GO:0120178 steroid hormone biosynthetic process 1/147 43/18722 0.287758979872807 0.394087504029105 PPARGC1A 1 GO:1903793 positive regulation of anion transport 1/147 43/18722 0.287758979872807 0.394087504029105 CEBPB 1 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 1/147 43/18722 0.287758979872807 0.394087504029105 SOD2 1 GO:0007272 ensheathment of neurons 2/147 136/18722 0.289353367402577 0.395908472964825 NDRG1/EPB41L3 2 GO:0008366 axon ensheathment 2/147 136/18722 0.289353367402577 0.395908472964825 NDRG1/EPB41L3 2 GO:0010639 negative regulation of organelle organization 4/147 347/18722 0.290487902109176 0.397279065024484 PPARGC1A/SNCA/HSPA1A/GCLC 4 GO:1901342 regulation of vasculature development 4/147 348/18722 0.292245023344702 0.397757137738993 CTSH/VEGFA/PKM/HIF1A 4 GO:0008203 cholesterol metabolic process 2/147 137/18722 0.292257282287453 0.397757137738993 PRKAA2/TSKU 2 GO:0010977 negative regulation of neuron projection development 2/147 137/18722 0.292257282287453 0.397757137738993 TSKU/SPOCK1 2 GO:0034754 cellular hormone metabolic process 2/147 137/18722 0.292257282287453 0.397757137738993 PPARGC1A/SHH 2 GO:0045471 response to ethanol 2/147 137/18722 0.292257282287453 0.397757137738993 ALAD/SOD2 2 GO:0002066 columnar/cuboidal epithelial cell development 1/147 44/18722 0.293364174474162 0.397757137738993 HIF1A 1 GO:0005978 glycogen biosynthetic process 1/147 44/18722 0.293364174474162 0.397757137738993 IRS2 1 GO:0008542 visual learning 1/147 44/18722 0.293364174474162 0.397757137738993 HIF1A 1 GO:0009126 purine nucleoside monophosphate metabolic process 1/147 44/18722 0.293364174474162 0.397757137738993 AK4 1 GO:0009250 glucan biosynthetic process 1/147 44/18722 0.293364174474162 0.397757137738993 IRS2 1 GO:0021517 ventral spinal cord development 1/147 44/18722 0.293364174474162 0.397757137738993 SHH 1 GO:0021762 substantia nigra development 1/147 44/18722 0.293364174474162 0.397757137738993 ZNF430 1 GO:0032881 regulation of polysaccharide metabolic process 1/147 44/18722 0.293364174474162 0.397757137738993 IRS2 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/147 44/18722 0.293364174474162 0.397757137738993 HLA-F 1 GO:0048806 genitalia development 1/147 44/18722 0.293364174474162 0.397757137738993 SHH 1 GO:0050999 regulation of nitric-oxide synthase activity 1/147 44/18722 0.293364174474162 0.397757137738993 HIF1A 1 GO:0060324 face development 1/147 44/18722 0.293364174474162 0.397757137738993 DLX5 1 GO:0060711 labyrinthine layer development 1/147 44/18722 0.293364174474162 0.397757137738993 SOCS3 1 GO:0089718 amino acid import across plasma membrane 1/147 44/18722 0.293364174474162 0.397757137738993 SLC7A2 1 GO:0032273 positive regulation of protein polymerization 2/147 138/18722 0.295159726579721 0.399648140425508 HSPA1A/HSPA1B 2 GO:0035107 appendage morphogenesis 2/147 138/18722 0.295159726579721 0.399648140425508 SHH/DLX5 2 GO:0035108 limb morphogenesis 2/147 138/18722 0.295159726579721 0.399648140425508 SHH/DLX5 2 GO:0002790 peptide secretion 3/147 242/18722 0.296008915218221 0.400616590686742 IRS2/GJA1/HIF1A 3 GO:0003254 regulation of membrane depolarization 1/147 45/18722 0.298925555047687 0.401475678108501 GCLC 1 GO:0030850 prostate gland development 1/147 45/18722 0.298925555047687 0.401475678108501 SHH 1 GO:0032309 icosanoid secretion 1/147 45/18722 0.298925555047687 0.401475678108501 BDKRB2 1 GO:0035305 negative regulation of dephosphorylation 1/147 45/18722 0.298925555047687 0.401475678108501 PPP1R15A 1 GO:0035307 positive regulation of protein dephosphorylation 1/147 45/18722 0.298925555047687 0.401475678108501 PPP1R15A 1 GO:0035384 thioester biosynthetic process 1/147 45/18722 0.298925555047687 0.401475678108501 SNCA 1 GO:0035987 endodermal cell differentiation 1/147 45/18722 0.298925555047687 0.401475678108501 DKK1 1 GO:0046189 phenol-containing compound biosynthetic process 1/147 45/18722 0.298925555047687 0.401475678108501 SNCA 1 GO:0048538 thymus development 1/147 45/18722 0.298925555047687 0.401475678108501 SHH 1 GO:0048599 oocyte development 1/147 45/18722 0.298925555047687 0.401475678108501 YTHDF2 1 GO:0060119 inner ear receptor cell development 1/147 45/18722 0.298925555047687 0.401475678108501 TSKU 1 GO:0071354 cellular response to interleukin-6 1/147 45/18722 0.298925555047687 0.401475678108501 PPARGC1A 1 GO:0071616 acyl-CoA biosynthetic process 1/147 45/18722 0.298925555047687 0.401475678108501 SNCA 1 GO:0085029 extracellular matrix assembly 1/147 45/18722 0.298925555047687 0.401475678108501 SMAD3 1 GO:0098534 centriole assembly 1/147 45/18722 0.298925555047687 0.401475678108501 CCDC57 1 GO:1904646 cellular response to amyloid-beta 1/147 45/18722 0.298925555047687 0.401475678108501 GJA1 1 GO:2000273 positive regulation of signaling receptor activity 1/147 45/18722 0.298925555047687 0.401475678108501 HIF1A 1 GO:0046165 alcohol biosynthetic process 2/147 140/18722 0.300959585699483 0.404026086547197 SNCA/PRKAA2 2 GO:0017148 negative regulation of translation 3/147 245/18722 0.302436402310588 0.405826504850142 PCIF1/TOB1/YTHDF2 3 GO:0006119 oxidative phosphorylation 2/147 141/18722 0.3038566978839 0.406332170496591 SNCA/AK4 2 GO:0016241 regulation of macroautophagy 2/147 141/18722 0.3038566978839 0.406332170496591 PRKAA2/HIF1A 2 GO:0016571 histone methylation 2/147 141/18722 0.3038566978839 0.406332170496591 NNMT/PIH1D1 2 GO:0032355 response to estradiol 2/147 141/18722 0.3038566978839 0.406332170496591 PPARGC1A/GJA1 2 GO:0048284 organelle fusion 2/147 141/18722 0.3038566978839 0.406332170496591 SNCA/SAMD9 2 GO:0006984 ER-nucleus signaling pathway 1/147 46/18722 0.304443461746192 0.406332170496591 PPP1R15A 1 GO:0010828 positive regulation of glucose transmembrane transport 1/147 46/18722 0.304443461746192 0.406332170496591 IRS2 1 GO:0010830 regulation of myotube differentiation 1/147 46/18722 0.304443461746192 0.406332170496591 ATP11A 1 GO:0043300 regulation of leukocyte degranulation 1/147 46/18722 0.304443461746192 0.406332170496591 HLA-F 1 GO:0048701 embryonic cranial skeleton morphogenesis 1/147 46/18722 0.304443461746192 0.406332170496591 SMAD3 1 GO:0060976 coronary vasculature development 1/147 46/18722 0.304443461746192 0.406332170496591 VEGFA 1 GO:0061028 establishment of endothelial barrier 1/147 46/18722 0.304443461746192 0.406332170496591 VEGFA 1 GO:0071216 cellular response to biotic stimulus 3/147 246/18722 0.30458059362506 0.406333878471256 PPARGC1A/CD55/CEBPB 3 GO:0019439 aromatic compound catabolic process 5/147 467/18722 0.305268290804408 0.407069753810069 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:0050729 positive regulation of inflammatory response 2/147 142/18722 0.306751734131642 0.408569886999763 SNCA/CEBPB 2 GO:0097553 calcium ion transmembrane import into cytosol 2/147 142/18722 0.306751734131642 0.408569886999763 SNCA/CHERP 2 GO:0006417 regulation of translation 5/147 468/18722 0.306803064594272 0.408569886999763 PPP1R15A/PCIF1/TOB1/YTHDF2/PKM 5 GO:1904062 regulation of cation transmembrane transport 4/147 357/18722 0.308120776554577 0.410142075066639 PPARGC1A/SNCA/GEM/SLC30A1 4 GO:0030010 establishment of cell polarity 2/147 143/18722 0.309644549191781 0.410524992121521 SHH/GJA1 2 GO:0001754 eye photoreceptor cell differentiation 1/147 47/18722 0.309918232099764 0.410524992121521 VEGFA 1 GO:0001774 microglial cell activation 1/147 47/18722 0.309918232099764 0.410524992121521 SNCA 1 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 1/147 47/18722 0.309918232099764 0.410524992121521 SOD2 1 GO:0019884 antigen processing and presentation of exogenous antigen 1/147 47/18722 0.309918232099764 0.410524992121521 HLA-F 1 GO:0032008 positive regulation of TOR signaling 1/147 47/18722 0.309918232099764 0.410524992121521 PIH1D1 1 GO:0072583 clathrin-dependent endocytosis 1/147 47/18722 0.309918232099764 0.410524992121521 DAB2 1 GO:0090279 regulation of calcium ion import 1/147 47/18722 0.309918232099764 0.410524992121521 SLC30A1 1 GO:0097028 dendritic cell differentiation 1/147 47/18722 0.309918232099764 0.410524992121521 CEBPB 1 GO:1903170 negative regulation of calcium ion transmembrane transport 1/147 47/18722 0.309918232099764 0.410524992121521 GEM 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/147 47/18722 0.309918232099764 0.410524992121521 VEGFA 1 GO:0046883 regulation of hormone secretion 3/147 249/18722 0.311017241151864 0.411798392335203 IRS2/GJA1/HIF1A 3 GO:2000146 negative regulation of cell motility 4/147 359/18722 0.311661914819127 0.41246937487788 PPARGC1A/SHH/MCC/GJA1 4 GO:0002715 regulation of natural killer cell mediated immunity 1/147 48/18722 0.315350201035846 0.415329128709034 HLA-F 1 GO:0035036 sperm-egg recognition 1/147 48/18722 0.315350201035846 0.415329128709034 B4GALT1 1 GO:0042149 cellular response to glucose starvation 1/147 48/18722 0.315350201035846 0.415329128709034 PRKAA2 1 GO:0042908 xenobiotic transport 1/147 48/18722 0.315350201035846 0.415329128709034 GJA1 1 GO:0045912 negative regulation of carbohydrate metabolic process 1/147 48/18722 0.315350201035846 0.415329128709034 PPARGC1A 1 GO:0048146 positive regulation of fibroblast proliferation 1/147 48/18722 0.315350201035846 0.415329128709034 MYC 1 GO:0061647 histone H3-K9 modification 1/147 48/18722 0.315350201035846 0.415329128709034 PIH1D1 1 GO:0097720 calcineurin-mediated signaling 1/147 48/18722 0.315350201035846 0.415329128709034 CHERP 1 GO:0120009 intermembrane lipid transfer 1/147 48/18722 0.315350201035846 0.415329128709034 PRELID3B 1 GO:1903053 regulation of extracellular matrix organization 1/147 48/18722 0.315350201035846 0.415329128709034 SMAD3 1 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 1/147 48/18722 0.315350201035846 0.415329128709034 SHH 1 GO:0007043 cell-cell junction assembly 2/147 146/18722 0.318308250227358 0.416557727047078 GJA1/EPB41L3 2 GO:0031589 cell-substrate adhesion 4/147 363/18722 0.318756057168248 0.416557727047078 STK4/VEGFA/SPOCK1/SMAD3 4 GO:0008654 phospholipid biosynthetic process 3/147 253/18722 0.319606293250169 0.416557727047078 SOCS1/PLSCR1/SOCS3 3 GO:0034612 response to tumor necrosis factor 3/147 253/18722 0.319606293250169 0.416557727047078 PPARGC1A/HSPA1A/HSPA1B 3 GO:0050767 regulation of neurogenesis 4/147 364/18722 0.320531822856847 0.416557727047078 SHH/VEGFA/YTHDF2/HIF1A 4 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 1/147 49/18722 0.320739700899171 0.416557727047078 SLC15A4 1 GO:0002208 somatic diversification of immunoglobulins involved in immune response 1/147 49/18722 0.320739700899171 0.416557727047078 SLC15A4 1 GO:0002762 negative regulation of myeloid leukocyte differentiation 1/147 49/18722 0.320739700899171 0.416557727047078 MYC 1 GO:0006692 prostanoid metabolic process 1/147 49/18722 0.320739700899171 0.416557727047078 PTGR2 1 GO:0006693 prostaglandin metabolic process 1/147 49/18722 0.320739700899171 0.416557727047078 PTGR2 1 GO:0006778 porphyrin-containing compound metabolic process 1/147 49/18722 0.320739700899171 0.416557727047078 ALAD 1 GO:0009066 aspartate family amino acid metabolic process 1/147 49/18722 0.320739700899171 0.416557727047078 MTAP 1 GO:0009994 oocyte differentiation 1/147 49/18722 0.320739700899171 0.416557727047078 YTHDF2 1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1/147 49/18722 0.320739700899171 0.416557727047078 DAB2 1 GO:0021515 cell differentiation in spinal cord 1/147 49/18722 0.320739700899171 0.416557727047078 SHH 1 GO:0030195 negative regulation of blood coagulation 1/147 49/18722 0.320739700899171 0.416557727047078 PLAT 1 GO:0030225 macrophage differentiation 1/147 49/18722 0.320739700899171 0.416557727047078 VEGFA 1 GO:0030857 negative regulation of epithelial cell differentiation 1/147 49/18722 0.320739700899171 0.416557727047078 VEGFA 1 GO:0034332 adherens junction organization 1/147 49/18722 0.320739700899171 0.416557727047078 VEGFA 1 GO:0038084 vascular endothelial growth factor signaling pathway 1/147 49/18722 0.320739700899171 0.416557727047078 VEGFA 1 GO:0042461 photoreceptor cell development 1/147 49/18722 0.320739700899171 0.416557727047078 VEGFA 1 GO:0043330 response to exogenous dsRNA 1/147 49/18722 0.320739700899171 0.416557727047078 IFIT1 1 GO:0045190 isotype switching 1/147 49/18722 0.320739700899171 0.416557727047078 SLC15A4 1 GO:0045778 positive regulation of ossification 1/147 49/18722 0.320739700899171 0.416557727047078 SMAD3 1 GO:0048168 regulation of neuronal synaptic plasticity 1/147 49/18722 0.320739700899171 0.416557727047078 SNCA 1 GO:0051932 synaptic transmission, GABAergic 1/147 49/18722 0.320739700899171 0.416557727047078 TPBG 1 GO:0060986 endocrine hormone secretion 1/147 49/18722 0.320739700899171 0.416557727047078 GJA1 1 GO:0070741 response to interleukin-6 1/147 49/18722 0.320739700899171 0.416557727047078 PPARGC1A 1 GO:0072091 regulation of stem cell proliferation 1/147 49/18722 0.320739700899171 0.416557727047078 GJA1 1 GO:0072666 establishment of protein localization to vacuole 1/147 49/18722 0.320739700899171 0.416557727047078 VPS13A 1 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/147 49/18722 0.320739700899171 0.416557727047078 STK4 1 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 1/147 49/18722 0.320739700899171 0.416557727047078 GJA1 1 GO:1902652 secondary alcohol metabolic process 2/147 147/18722 0.32119077515371 0.416962503682615 PRKAA2/TSKU 2 GO:0002181 cytoplasmic translation 2/147 148/18722 0.324070387740859 0.41967573186806 YTHDF2/PKM 2 GO:0010212 response to ionizing radiation 2/147 148/18722 0.324070387740859 0.41967573186806 ALAD/MYC 2 GO:0014074 response to purine-containing compound 2/147 148/18722 0.324070387740859 0.41967573186806 PPARGC1A/FOS 2 GO:0043484 regulation of RNA splicing 2/147 148/18722 0.324070387740859 0.41967573186806 HSPA1A/RBM15B 2 GO:0051384 response to glucocorticoid 2/147 148/18722 0.324070387740859 0.41967573186806 ALAD/FOS 2 GO:0051271 negative regulation of cellular component movement 4/147 367/18722 0.325863815124775 0.41967573186806 PPARGC1A/SHH/MCC/GJA1 4 GO:0007140 male meiotic nuclear division 1/147 50/18722 0.326087061471539 0.41967573186806 MOV10L1 1 GO:0007632 visual behavior 1/147 50/18722 0.326087061471539 0.41967573186806 HIF1A 1 GO:0015872 dopamine transport 1/147 50/18722 0.326087061471539 0.41967573186806 SNCA 1 GO:0018023 peptidyl-lysine trimethylation 1/147 50/18722 0.326087061471539 0.41967573186806 PIH1D1 1 GO:0019083 viral transcription 1/147 50/18722 0.326087061471539 0.41967573186806 HEXIM1 1 GO:0030490 maturation of SSU-rRNA 1/147 50/18722 0.326087061471539 0.41967573186806 NOP14 1 GO:0045058 T cell selection 1/147 50/18722 0.326087061471539 0.41967573186806 SHH 1 GO:0046460 neutral lipid biosynthetic process 1/147 50/18722 0.326087061471539 0.41967573186806 LPIN3 1 GO:0046463 acylglycerol biosynthetic process 1/147 50/18722 0.326087061471539 0.41967573186806 LPIN3 1 GO:0051646 mitochondrion localization 1/147 50/18722 0.326087061471539 0.41967573186806 HIF1A 1 GO:0060337 type I interferon signaling pathway 1/147 50/18722 0.326087061471539 0.41967573186806 YTHDF2 1 GO:0070231 T cell apoptotic process 1/147 50/18722 0.326087061471539 0.41967573186806 HIF1A 1 GO:1900047 negative regulation of hemostasis 1/147 50/18722 0.326087061471539 0.41967573186806 PLAT 1 GO:1902930 regulation of alcohol biosynthetic process 1/147 50/18722 0.326087061471539 0.41967573186806 SNCA 1 GO:0009411 response to UV 2/147 149/18722 0.326946956587571 0.420239942910798 MAP3K4/MYC 2 GO:0032368 regulation of lipid transport 2/147 149/18722 0.326946956587571 0.420239942910798 SHH/IRS2 2 GO:0045834 positive regulation of lipid metabolic process 2/147 149/18722 0.326946956587571 0.420239942910798 PPARGC1A/IRS2 2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1/147 51/18722 0.331392609991445 0.424494773654994 SNCA 1 GO:0010874 regulation of cholesterol efflux 1/147 51/18722 0.331392609991445 0.424494773654994 SHH 1 GO:0032873 negative regulation of stress-activated MAPK cascade 1/147 51/18722 0.331392609991445 0.424494773654994 MYC 1 GO:0045104 intermediate filament cytoskeleton organization 1/147 51/18722 0.331392609991445 0.424494773654994 SHH 1 GO:0051293 establishment of spindle localization 1/147 51/18722 0.331392609991445 0.424494773654994 GJA1 1 GO:0060043 regulation of cardiac muscle cell proliferation 1/147 51/18722 0.331392609991445 0.424494773654994 GJA1 1 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 1/147 51/18722 0.331392609991445 0.424494773654994 MYC 1 GO:1903307 positive regulation of regulated secretory pathway 1/147 51/18722 0.331392609991445 0.424494773654994 HLA-F 1 GO:0045927 positive regulation of growth 3/147 259/18722 0.332495568505022 0.425725276283614 GH2/TFCP2L1/VEGFA 3 GO:0043535 regulation of blood vessel endothelial cell migration 2/147 151/18722 0.332690448497649 0.425792525227415 VEGFA/HIF1A 2 GO:0016125 sterol metabolic process 2/147 152/18722 0.335557119722975 0.42865657888692 PRKAA2/TSKU 2 GO:0050871 positive regulation of B cell activation 2/147 152/18722 0.335557119722975 0.42865657888692 IGKC/IRS2 2 GO:0051092 positive regulation of NF-kappaB transcription factor activity 2/147 152/18722 0.335557119722975 0.42865657888692 HSPA1A/HSPA1B 2 GO:0002218 activation of innate immune response 1/147 52/18722 0.33665667117356 0.42865657888692 HEXIM1 1 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 1/147 52/18722 0.33665667117356 0.42865657888692 COPB2 1 GO:0032206 positive regulation of telomere maintenance 1/147 52/18722 0.33665667117356 0.42865657888692 MAP3K4 1 GO:0035176 social behavior 1/147 52/18722 0.33665667117356 0.42865657888692 VPS13A 1 GO:0035196 production of miRNAs involved in gene silencing by miRNA 1/147 52/18722 0.33665667117356 0.42865657888692 SMAD3 1 GO:0043090 amino acid import 1/147 52/18722 0.33665667117356 0.42865657888692 SLC7A2 1 GO:0045103 intermediate filament-based process 1/147 52/18722 0.33665667117356 0.42865657888692 SHH 1 GO:0051496 positive regulation of stress fiber assembly 1/147 52/18722 0.33665667117356 0.42865657888692 SMAD3 1 GO:2000378 negative regulation of reactive oxygen species metabolic process 1/147 52/18722 0.33665667117356 0.42865657888692 HIF1A 1 GO:0051321 meiotic cell cycle 3/147 261/18722 0.336791360877386 0.42865657888692 MOV10L1/YTHDF2/STK35 3 GO:0007338 single fertilization 2/147 153/18722 0.338420243480103 0.430546553912798 B4GALT1/PLAT 2 GO:0008360 regulation of cell shape 2/147 154/18722 0.341279699177169 0.432938523019324 VEGFA/EPB41L3 2 GO:0032210 regulation of telomere maintenance via telomerase 1/147 53/18722 0.341879567228058 0.432938523019324 MAP3K4 1 GO:0033059 cellular pigmentation 1/147 53/18722 0.341879567228058 0.432938523019324 MLPH 1 GO:0034381 plasma lipoprotein particle clearance 1/147 53/18722 0.341879567228058 0.432938523019324 CNPY2 1 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1/147 53/18722 0.341879567228058 0.432938523019324 SNCA 1 GO:0045806 negative regulation of endocytosis 1/147 53/18722 0.341879567228058 0.432938523019324 PACSIN2 1 GO:0050819 negative regulation of coagulation 1/147 53/18722 0.341879567228058 0.432938523019324 PLAT 1 GO:0051438 regulation of ubiquitin-protein transferase activity 1/147 53/18722 0.341879567228058 0.432938523019324 DCUN1D1 1 GO:0071715 icosanoid transport 1/147 53/18722 0.341879567228058 0.432938523019324 BDKRB2 1 GO:0097479 synaptic vesicle localization 1/147 53/18722 0.341879567228058 0.432938523019324 SNCA 1 GO:0044282 small molecule catabolic process 4/147 376/18722 0.34189260828206 0.432938523019324 MCAT/LPIN3/IRS2/ALDH5A1 4 GO:0006606 protein import into nucleus 2/147 155/18722 0.344135368307589 0.435225744865962 SHH/SMAD3 2 GO:0010970 transport along microtubule 2/147 155/18722 0.344135368307589 0.435225744865962 IFT46/HIF1A 2 GO:0034614 cellular response to reactive oxygen species 2/147 155/18722 0.344135368307589 0.435225744865962 FOS/SOD2 2 GO:0001764 neuron migration 2/147 156/18722 0.346987134425137 0.436527039141505 VEGFA/SPOCK1 2 GO:0035051 cardiocyte differentiation 2/147 156/18722 0.346987134425137 0.436527039141505 VEGFA/DKK1 2 GO:0001706 endoderm formation 1/147 54/18722 0.347061617879805 0.436527039141505 DKK1 1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/147 54/18722 0.347061617879805 0.436527039141505 VEGFA 1 GO:0006584 catecholamine metabolic process 1/147 54/18722 0.347061617879805 0.436527039141505 SNCA 1 GO:0009712 catechol-containing compound metabolic process 1/147 54/18722 0.347061617879805 0.436527039141505 SNCA 1 GO:0010524 positive regulation of calcium ion transport into cytosol 1/147 54/18722 0.347061617879805 0.436527039141505 SNCA 1 GO:0031050 dsRNA processing 1/147 54/18722 0.347061617879805 0.436527039141505 SMAD3 1 GO:0032330 regulation of chondrocyte differentiation 1/147 54/18722 0.347061617879805 0.436527039141505 SMAD3 1 GO:0043647 inositol phosphate metabolic process 1/147 54/18722 0.347061617879805 0.436527039141505 SNCA 1 GO:0051703 biological process involved in intraspecies interaction between organisms 1/147 54/18722 0.347061617879805 0.436527039141505 VPS13A 1 GO:0070918 production of small RNA involved in gene silencing by RNA 1/147 54/18722 0.347061617879805 0.436527039141505 SMAD3 1 GO:0086002 cardiac muscle cell action potential involved in contraction 1/147 54/18722 0.347061617879805 0.436527039141505 GJA1 1 GO:1901361 organic cyclic compound catabolic process 5/147 495/18722 0.348600828367067 0.43827872116263 HSPA1A/ALKBH5/TOB1/YTHDF2/HSPA1B 5 GO:1902600 proton transmembrane transport 2/147 157/18722 0.349834883119284 0.439645435046125 SLC15A4/SLC15A1 2 GO:0050708 regulation of protein secretion 3/147 268/18722 0.351813936791329 0.441693749643059 IRS2/GJA1/HIF1A 3 GO:0006360 transcription by RNA polymerase I 1/147 55/18722 0.352203140387394 0.441693749643059 PIH1D1 1 GO:0042220 response to cocaine 1/147 55/18722 0.352203140387394 0.441693749643059 SNCA 1 GO:0043331 response to dsRNA 1/147 55/18722 0.352203140387394 0.441693749643059 IFIT1 1 GO:0048016 inositol phosphate-mediated signaling 1/147 55/18722 0.352203140387394 0.441693749643059 CHERP 1 GO:1902903 regulation of supramolecular fiber organization 4/147 382/18722 0.352595149572323 0.442000038713671 SNCA/HSPA1A/HSPA1B/SMAD3 4 GO:0006644 phospholipid metabolic process 4/147 383/18722 0.354379482167537 0.444050704299583 SOCS1/PLSCR1/SNCA/SOCS3 4 GO:0032200 telomere organization 2/147 159/18722 0.355517880627598 0.444731903369781 MAP3K4/MYC 2 GO:0046488 phosphatidylinositol metabolic process 2/147 159/18722 0.355517880627598 0.444731903369781 SOCS1/SOCS3 2 GO:0051170 import into nucleus 2/147 159/18722 0.355517880627598 0.444731903369781 SHH/SMAD3 2 GO:1903169 regulation of calcium ion transmembrane transport 2/147 159/18722 0.355517880627598 0.444731903369781 SNCA/GEM 2 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1/147 56/18722 0.357304449562036 0.445476285385599 TOB1 1 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/147 56/18722 0.357304449562036 0.445476285385599 HLA-F 1 GO:0010332 response to gamma radiation 1/147 56/18722 0.357304449562036 0.445476285385599 MYC 1 GO:0042733 embryonic digit morphogenesis 1/147 56/18722 0.357304449562036 0.445476285385599 SHH 1 GO:0050433 regulation of catecholamine secretion 1/147 56/18722 0.357304449562036 0.445476285385599 SNCA 1 GO:0051653 spindle localization 1/147 56/18722 0.357304449562036 0.445476285385599 GJA1 1 GO:0098781 ncRNA transcription 1/147 56/18722 0.357304449562036 0.445476285385599 PIH1D1 1 GO:1904645 response to amyloid-beta 1/147 56/18722 0.357304449562036 0.445476285385599 GJA1 1 GO:0060402 calcium ion transport into cytosol 2/147 160/18722 0.358352910580838 0.44659731481137 SNCA/CHERP 2 GO:0050727 regulation of inflammatory response 4/147 386/18722 0.359732711342799 0.448130170606544 SNCA/SMAD3/CEBPB/SOCS3 4 GO:0051650 establishment of vesicle localization 2/147 161/18722 0.361183485341275 0.449724597775464 SNCA/MLPH 2 GO:0006611 protein export from nucleus 1/147 57/18722 0.362365857786315 0.449724597775464 CCHCR1 1 GO:0006695 cholesterol biosynthetic process 1/147 57/18722 0.362365857786315 0.449724597775464 PRKAA2 1 GO:0010883 regulation of lipid storage 1/147 57/18722 0.362365857786315 0.449724597775464 PLIN2 1 GO:0016447 somatic recombination of immunoglobulin gene segments 1/147 57/18722 0.362365857786315 0.449724597775464 SLC15A4 1 GO:0033619 membrane protein proteolysis 1/147 57/18722 0.362365857786315 0.449724597775464 CTSH 1 GO:0051289 protein homotetramerization 1/147 57/18722 0.362365857786315 0.449724597775464 SOD2 1 GO:0061005 cell differentiation involved in kidney development 1/147 57/18722 0.362365857786315 0.449724597775464 SHH 1 GO:1902653 secondary alcohol biosynthetic process 1/147 57/18722 0.362365857786315 0.449724597775464 PRKAA2 1 GO:0034249 negative regulation of cellular amide metabolic process 3/147 273/18722 0.362523543770802 0.449733687025495 PCIF1/TOB1/YTHDF2 3 GO:0006633 fatty acid biosynthetic process 2/147 163/18722 0.366830852804543 0.453697991751887 MCAT/PRKAA2 2 GO:0050657 nucleic acid transport 2/147 163/18722 0.366830852804543 0.453697991751887 ALKBH5/RBM15B 2 GO:0050658 RNA transport 2/147 163/18722 0.366830852804543 0.453697991751887 ALKBH5/RBM15B 2 GO:0002763 positive regulation of myeloid leukocyte differentiation 1/147 58/18722 0.367387675032788 0.453697991751887 FOS 1 GO:0009161 ribonucleoside monophosphate metabolic process 1/147 58/18722 0.367387675032788 0.453697991751887 AK4 1 GO:0010574 regulation of vascular endothelial growth factor production 1/147 58/18722 0.367387675032788 0.453697991751887 HIF1A 1 GO:0043666 regulation of phosphoprotein phosphatase activity 1/147 58/18722 0.367387675032788 0.453697991751887 PPP1R15A 1 GO:0045604 regulation of epidermal cell differentiation 1/147 58/18722 0.367387675032788 0.453697991751887 MAFF 1 GO:0050432 catecholamine secretion 1/147 58/18722 0.367387675032788 0.453697991751887 SNCA 1 GO:0086065 cell communication involved in cardiac conduction 1/147 58/18722 0.367387675032788 0.453697991751887 GJA1 1 GO:2000736 regulation of stem cell differentiation 1/147 58/18722 0.367387675032788 0.453697991751887 YTHDF2 1 GO:0040013 negative regulation of locomotion 4/147 391/18722 0.368653307195722 0.455073067198681 PPARGC1A/SHH/MCC/GJA1 4 GO:0007548 sex differentiation 3/147 276/18722 0.368937383548764 0.45523585569074 SHH/VEGFA/CEBPB 3 GO:0046486 glycerolipid metabolic process 4/147 392/18722 0.37043687915692 0.456897610539525 SOCS1/PLSCR1/LPIN3/SOCS3 4 GO:0001836 release of cytochrome c from mitochondria 1/147 59/18722 0.372370208882454 0.458525852106802 SOD2 1 GO:0033013 tetrapyrrole metabolic process 1/147 59/18722 0.372370208882454 0.458525852106802 ALAD 1 GO:0046324 regulation of glucose import 1/147 59/18722 0.372370208882454 0.458525852106802 IRS2 1 GO:2001258 negative regulation of cation channel activity 1/147 59/18722 0.372370208882454 0.458525852106802 GEM 1 GO:0051236 establishment of RNA localization 2/147 166/18722 0.375265936270838 0.461802986419812 ALKBH5/RBM15B 2 GO:0043542 endothelial cell migration 3/147 279/18722 0.375340374452211 0.461802986419812 ATOH8/VEGFA/HIF1A 3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 1/147 60/18722 0.377313764543081 0.463658779682973 RBM15B 1 GO:0031663 lipopolysaccharide-mediated signaling pathway 1/147 60/18722 0.377313764543081 0.463658779682973 CD55 1 GO:0060038 cardiac muscle cell proliferation 1/147 60/18722 0.377313764543081 0.463658779682973 GJA1 1 GO:0031960 response to corticosteroid 2/147 167/18722 0.37806764887913 0.464394389239211 ALAD/FOS 2 GO:0016482 cytosolic transport 2/147 168/18722 0.380864213102984 0.467637463625215 VPS13A/DAB2 2 GO:0030865 cortical cytoskeleton organization 1/147 61/18722 0.382218644867386 0.468339191642094 EPB41L3 1 GO:0043030 regulation of macrophage activation 1/147 61/18722 0.382218644867386 0.468339191642094 SNCA 1 GO:0043966 histone H3 acetylation 1/147 61/18722 0.382218644867386 0.468339191642094 PIH1D1 1 GO:0050994 regulation of lipid catabolic process 1/147 61/18722 0.382218644867386 0.468339191642094 IRS2 1 GO:1904356 regulation of telomere maintenance via telomere lengthening 1/147 61/18722 0.382218644867386 0.468339191642094 MAP3K4 1 GO:0021543 pallium development 2/147 169/18722 0.383655537127527 0.469907334786418 TSKU/HIF1A 2 GO:0006520 cellular amino acid metabolic process 3/147 284/18722 0.385983831621487 0.471021840829906 MTAP/ALDH5A1/GCLC 3 GO:0015850 organic hydroxy compound transport 3/147 284/18722 0.385983831621487 0.471021840829906 SNCA/SHH/TSKU 3 GO:0002260 lymphocyte homeostasis 1/147 62/18722 0.387085150371083 0.471021840829906 HIF1A 1 GO:0009116 nucleoside metabolic process 1/147 62/18722 0.387085150371083 0.471021840829906 MTAP 1 GO:0009311 oligosaccharide metabolic process 1/147 62/18722 0.387085150371083 0.471021840829906 B4GALT1 1 GO:0010573 vascular endothelial growth factor production 1/147 62/18722 0.387085150371083 0.471021840829906 HIF1A 1 GO:0032731 positive regulation of interleukin-1 beta production 1/147 62/18722 0.387085150371083 0.471021840829906 SMAD3 1 GO:0045428 regulation of nitric oxide biosynthetic process 1/147 62/18722 0.387085150371083 0.471021840829906 SMAD3 1 GO:0046148 pigment biosynthetic process 1/147 62/18722 0.387085150371083 0.471021840829906 ALAD 1 GO:0046173 polyol biosynthetic process 1/147 62/18722 0.387085150371083 0.471021840829906 SNCA 1 GO:0048002 antigen processing and presentation of peptide antigen 1/147 62/18722 0.387085150371083 0.471021840829906 HLA-F 1 GO:0048488 synaptic vesicle endocytosis 1/147 62/18722 0.387085150371083 0.471021840829906 SNCA 1 GO:0048663 neuron fate commitment 1/147 62/18722 0.387085150371083 0.471021840829906 SHH 1 GO:0060113 inner ear receptor cell differentiation 1/147 62/18722 0.387085150371083 0.471021840829906 TSKU 1 GO:0060135 maternal process involved in female pregnancy 1/147 62/18722 0.387085150371083 0.471021840829906 GJA1 1 GO:0140238 presynaptic endocytosis 1/147 62/18722 0.387085150371083 0.471021840829906 SNCA 1 GO:0001756 somitogenesis 1/147 63/18722 0.391913579250796 0.475736004683089 SMAD3 1 GO:0022617 extracellular matrix disassembly 1/147 63/18722 0.391913579250796 0.475736004683089 WDR72 1 GO:0031343 positive regulation of cell killing 1/147 63/18722 0.391913579250796 0.475736004683089 HLA-F 1 GO:0032233 positive regulation of actin filament bundle assembly 1/147 63/18722 0.391913579250796 0.475736004683089 SMAD3 1 GO:0099601 regulation of neurotransmitter receptor activity 1/147 63/18722 0.391913579250796 0.475736004683089 PPARGC1A 1 GO:1902373 negative regulation of mRNA catabolic process 1/147 63/18722 0.391913579250796 0.475736004683089 TOB1 1 GO:0006694 steroid biosynthetic process 2/147 173/18722 0.39476665530334 0.47881065126208 PPARGC1A/PRKAA2 2 GO:0051099 positive regulation of binding 2/147 173/18722 0.39476665530334 0.47881065126208 STK4/PARP9 2 GO:0010959 regulation of metal ion transport 4/147 406/18722 0.395362908691457 0.47883064736032 SNCA/GEM/SLC30A1/GJA1 4 GO:0001885 endothelial cell development 1/147 64/18722 0.39670422740183 0.47883064736032 VEGFA 1 GO:0006749 glutathione metabolic process 1/147 64/18722 0.39670422740183 0.47883064736032 GCLC 1 GO:0016126 sterol biosynthetic process 1/147 64/18722 0.39670422740183 0.47883064736032 PRKAA2 1 GO:0030858 positive regulation of epithelial cell differentiation 1/147 64/18722 0.39670422740183 0.47883064736032 ATOH8 1 GO:0030888 regulation of B cell proliferation 1/147 64/18722 0.39670422740183 0.47883064736032 IRS2 1 GO:0046530 photoreceptor cell differentiation 1/147 64/18722 0.39670422740183 0.47883064736032 VEGFA 1 GO:0046888 negative regulation of hormone secretion 1/147 64/18722 0.39670422740183 0.47883064736032 GJA1 1 GO:0048857 neural nucleus development 1/147 64/18722 0.39670422740183 0.47883064736032 ZNF430 1 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 1/147 64/18722 0.39670422740183 0.47883064736032 HIF1A 1 GO:0080164 regulation of nitric oxide metabolic process 1/147 64/18722 0.39670422740183 0.47883064736032 SMAD3 1 GO:0098930 axonal transport 1/147 64/18722 0.39670422740183 0.47883064736032 HIF1A 1 GO:0034504 protein localization to nucleus 3/147 290/18722 0.398701208857385 0.481046920408407 SHH/PARP9/SMAD3 3 GO:0022900 electron transport chain 2/147 175/18722 0.400288511721748 0.482572728157899 PPARGC1A/SNCA 2 GO:0048771 tissue remodeling 2/147 175/18722 0.400288511721748 0.482572728157899 GJA1/HIF1A 2 GO:0006325 chromatin organization 4/147 409/18722 0.400688268854908 0.482814253643545 CBX4/MYC/PIH1D1/TLK1 4 GO:0006487 protein N-linked glycosylation 1/147 65/18722 0.401457388435806 0.482814253643545 B4GALT1 1 GO:0033692 cellular polysaccharide biosynthetic process 1/147 65/18722 0.401457388435806 0.482814253643545 IRS2 1 GO:0045682 regulation of epidermis development 1/147 65/18722 0.401457388435806 0.482814253643545 MAFF 1 GO:0048524 positive regulation of viral process 1/147 65/18722 0.401457388435806 0.482814253643545 IFIT1 1 GO:0051310 metaphase plate congression 1/147 65/18722 0.401457388435806 0.482814253643545 GEM 1 GO:0043534 blood vessel endothelial cell migration 2/147 176/18722 0.403040726832753 0.484328973064188 VEGFA/HIF1A 2 GO:0050728 negative regulation of inflammatory response 2/147 176/18722 0.403040726832753 0.484328973064188 SMAD3/SOCS3 2 GO:0051648 vesicle localization 2/147 177/18722 0.405787028016017 0.486529635927605 SNCA/MLPH 2 GO:0071466 cellular response to xenobiotic stimulus 2/147 177/18722 0.405787028016017 0.486529635927605 PRKAA2/MYC 2 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 1/147 66/18722 0.406173353698171 0.486529635927605 SLC15A4 1 GO:0006303 double-strand break repair via nonhomologous end joining 1/147 66/18722 0.406173353698171 0.486529635927605 PARP9 1 GO:0014015 positive regulation of gliogenesis 1/147 66/18722 0.406173353698171 0.486529635927605 SHH 1 GO:0016444 somatic cell DNA recombination 1/147 66/18722 0.406173353698171 0.486529635927605 SLC15A4 1 GO:0030193 regulation of blood coagulation 1/147 66/18722 0.406173353698171 0.486529635927605 PLAT 1 GO:0050909 sensory perception of taste 1/147 66/18722 0.406173353698171 0.486529635927605 CST2 1 GO:0051604 protein maturation 3/147 294/18722 0.407141132196805 0.487493645476639 SHH/CTSH/PLAT 3 GO:0046879 hormone secretion 3/147 295/18722 0.409245869541864 0.489817685394043 IRS2/GJA1/HIF1A 3 GO:0010517 regulation of phospholipase activity 1/147 67/18722 0.410852412285562 0.4907586122788 SNCA 1 GO:0016445 somatic diversification of immunoglobulins 1/147 67/18722 0.410852412285562 0.4907586122788 SLC15A4 1 GO:0042490 mechanoreceptor differentiation 1/147 67/18722 0.410852412285562 0.4907586122788 TSKU 1 GO:0043967 histone H4 acetylation 1/147 67/18722 0.410852412285562 0.4907586122788 PIH1D1 1 GO:0072665 protein localization to vacuole 1/147 67/18722 0.410852412285562 0.4907586122788 VPS13A 1 GO:0007626 locomotory behavior 2/147 179/18722 0.41126158245266 0.490958940694638 SNCA/VPS13A 2 GO:0048193 Golgi vesicle transport 3/147 296/18722 0.411348413701359 0.490958940694638 COG1/VPS13A/COPB2 3 GO:0015698 inorganic anion transport 2/147 180/18722 0.413989686497762 0.493914300883448 SLC39A14/CEBPB 2 GO:0016311 dephosphorylation 4/147 417/18722 0.414849634051248 0.493998522918861 PPP2R1B/LPIN3/PPP1R15A/SMAD3 4 GO:0009988 cell-cell recognition 1/147 68/18722 0.415494851063049 0.493998522918861 B4GALT1 1 GO:0010812 negative regulation of cell-substrate adhesion 1/147 68/18722 0.415494851063049 0.493998522918861 SPOCK1 1 GO:0032922 circadian regulation of gene expression 1/147 68/18722 0.415494851063049 0.493998522918861 PPARGC1A 1 GO:0042267 natural killer cell mediated cytotoxicity 1/147 68/18722 0.415494851063049 0.493998522918861 HLA-F 1 GO:1900046 regulation of hemostasis 1/147 68/18722 0.415494851063049 0.493998522918861 PLAT 1 GO:1901607 alpha-amino acid biosynthetic process 1/147 68/18722 0.415494851063049 0.493998522918861 MTAP 1 GO:1904888 cranial skeletal system development 1/147 68/18722 0.415494851063049 0.493998522918861 SMAD3 1 GO:0010720 positive regulation of cell development 3/147 298/18722 0.415546734758895 0.493998522918861 SHH/VEGFA/HIF1A 3 GO:0006479 protein methylation 2/147 181/18722 0.416711578160052 0.494596956459014 NNMT/PIH1D1 2 GO:0008213 protein alkylation 2/147 181/18722 0.416711578160052 0.494596956459014 NNMT/PIH1D1 2 GO:0008361 regulation of cell size 2/147 181/18722 0.416711578160052 0.494596956459014 DEPTOR/VEGFA 2 GO:0099504 synaptic vesicle cycle 2/147 181/18722 0.416711578160052 0.494596956459014 SNCA/DNAJC5 2 GO:0042254 ribosome biogenesis 3/147 299/18722 0.417642419008216 0.49550514686774 NOP14/YTHDF2/PIH1D1 3 GO:0051260 protein homooligomerization 2/147 182/18722 0.419427186614147 0.49664899424964 ALAD/SOD2 2 GO:0060401 cytosolic calcium ion transport 2/147 182/18722 0.419427186614147 0.49664899424964 SNCA/CHERP 2 GO:0016050 vesicle organization 3/147 300/18722 0.41973572477127 0.49664899424964 SNCA/SRPX/SAMD9 3 GO:0007004 telomere maintenance via telomerase 1/147 69/18722 0.42010095468124 0.49664899424964 MAP3K4 1 GO:0010611 regulation of cardiac muscle hypertrophy 1/147 69/18722 0.42010095468124 0.49664899424964 SMAD3 1 GO:0045665 negative regulation of neuron differentiation 1/147 69/18722 0.42010095468124 0.49664899424964 SHH 1 GO:0045669 positive regulation of osteoblast differentiation 1/147 69/18722 0.42010095468124 0.49664899424964 CEBPB 1 GO:0050810 regulation of steroid biosynthetic process 1/147 69/18722 0.42010095468124 0.49664899424964 PPARGC1A 1 GO:0051966 regulation of synaptic transmission, glutamatergic 1/147 69/18722 0.42010095468124 0.49664899424964 ATAD1 1 GO:0042063 gliogenesis 3/147 301/18722 0.421826606919973 0.498492051085595 SHH/NDRG1/TRPC4 3 GO:0072594 establishment of protein localization to organelle 4/147 422/18722 0.423665783544069 0.500467756153361 SHH/VPS13A/SMAD3/PIH1D1 4 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 1/147 70/18722 0.424671005593257 0.500864911468103 SLC15A4 1 GO:0070830 bicellular tight junction assembly 1/147 70/18722 0.424671005593257 0.500864911468103 GJA1 1 GO:0007051 spindle organization 2/147 184/18722 0.424839277965422 0.500864911468103 HSPA1A/HSPA1B 2 GO:0055001 muscle cell development 2/147 184/18722 0.424839277965422 0.500864911468103 VEGFA/MYOF 2 GO:2001257 regulation of cation channel activity 2/147 184/18722 0.424839277965422 0.500864911468103 PPARGC1A/GEM 2 GO:0002040 sprouting angiogenesis 2/147 185/18722 0.427535626525584 0.503845176886533 VEGFA/PKM 2 GO:0002228 natural killer cell mediated immunity 1/147 71/18722 0.429205284071586 0.504421612832264 HLA-F 1 GO:0003208 cardiac ventricle morphogenesis 1/147 71/18722 0.429205284071586 0.504421612832264 HIF1A 1 GO:0008344 adult locomotory behavior 1/147 71/18722 0.429205284071586 0.504421612832264 SNCA 1 GO:0032722 positive regulation of chemokine production 1/147 71/18722 0.429205284071586 0.504421612832264 HIF1A 1 GO:0033555 multicellular organismal response to stress 1/147 71/18722 0.429205284071586 0.504421612832264 GJA1 1 GO:0050795 regulation of behavior 1/147 71/18722 0.429205284071586 0.504421612832264 GJA1 1 GO:0050818 regulation of coagulation 1/147 71/18722 0.429205284071586 0.504421612832264 PLAT 1 GO:0031345 negative regulation of cell projection organization 2/147 186/18722 0.430225423167002 0.505223494578918 TSKU/SPOCK1 2 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 2/147 186/18722 0.430225423167002 0.505223494578918 SLC35B2/GJA1 2 GO:0006650 glycerophospholipid metabolic process 3/147 306/18722 0.432243117151849 0.506920229800844 SOCS1/PLSCR1/SOCS3 3 GO:0009914 hormone transport 3/147 306/18722 0.432243117151849 0.506920229800844 IRS2/GJA1/HIF1A 3 GO:0033044 regulation of chromosome organization 2/147 187/18722 0.4329086042685 0.506920229800844 MAP3K4/MYC 2 GO:0000271 polysaccharide biosynthetic process 1/147 72/18722 0.433704068224794 0.506920229800844 IRS2 1 GO:0002534 cytokine production involved in inflammatory response 1/147 72/18722 0.433704068224794 0.506920229800844 HIF1A 1 GO:0005977 glycogen metabolic process 1/147 72/18722 0.433704068224794 0.506920229800844 IRS2 1 GO:0014743 regulation of muscle hypertrophy 1/147 72/18722 0.433704068224794 0.506920229800844 SMAD3 1 GO:0030330 DNA damage response, signal transduction by p53 class mediator 1/147 72/18722 0.433704068224794 0.506920229800844 NDRG1 1 GO:0042246 tissue regeneration 1/147 72/18722 0.433704068224794 0.506920229800844 PTGFRN 1 GO:0055021 regulation of cardiac muscle tissue growth 1/147 72/18722 0.433704068224794 0.506920229800844 GJA1 1 GO:1900015 regulation of cytokine production involved in inflammatory response 1/147 72/18722 0.433704068224794 0.506920229800844 HIF1A 1 GO:1905818 regulation of chromosome separation 1/147 72/18722 0.433704068224794 0.506920229800844 PLSCR1 1 GO:0006575 cellular modified amino acid metabolic process 2/147 188/18722 0.435585107595647 0.508757528469036 PLSCR1/GCLC 2 GO:0002637 regulation of immunoglobulin production 1/147 73/18722 0.438167634014121 0.508757528469036 SLC15A4 1 GO:0006073 cellular glucan metabolic process 1/147 73/18722 0.438167634014121 0.508757528469036 IRS2 1 GO:0032732 positive regulation of interleukin-1 production 1/147 73/18722 0.438167634014121 0.508757528469036 SMAD3 1 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 1/147 73/18722 0.438167634014121 0.508757528469036 HIF1A 1 GO:0035924 cellular response to vascular endothelial growth factor stimulus 1/147 73/18722 0.438167634014121 0.508757528469036 VEGFA 1 GO:0042274 ribosomal small subunit biogenesis 1/147 73/18722 0.438167634014121 0.508757528469036 NOP14 1 GO:0043299 leukocyte degranulation 1/147 73/18722 0.438167634014121 0.508757528469036 HLA-F 1 GO:0044042 glucan metabolic process 1/147 73/18722 0.438167634014121 0.508757528469036 IRS2 1 GO:0045739 positive regulation of DNA repair 1/147 73/18722 0.438167634014121 0.508757528469036 PARP9 1 GO:0050848 regulation of calcium-mediated signaling 1/147 73/18722 0.438167634014121 0.508757528469036 CHERP 1 GO:0051298 centrosome duplication 1/147 73/18722 0.438167634014121 0.508757528469036 CCDC57 1 GO:0051937 catecholamine transport 1/147 73/18722 0.438167634014121 0.508757528469036 SNCA 1 GO:0061035 regulation of cartilage development 1/147 73/18722 0.438167634014121 0.508757528469036 SMAD3 1 GO:0070988 demethylation 1/147 73/18722 0.438167634014121 0.508757528469036 ALKBH5 1 GO:0086003 cardiac muscle cell contraction 1/147 73/18722 0.438167634014121 0.508757528469036 GJA1 1 GO:1904427 positive regulation of calcium ion transmembrane transport 1/147 73/18722 0.438167634014121 0.508757528469036 SNCA 1 GO:0022604 regulation of cell morphogenesis 3/147 309/18722 0.438461154725155 0.508900781444679 VEGFA/BCL9L/EPB41L3 3 GO:0009566 fertilization 2/147 190/18722 0.440917838817579 0.511355275650787 B4GALT1/PLAT 2 GO:0099111 microtubule-based transport 2/147 190/18722 0.440917838817579 0.511355275650787 IFT46/HIF1A 2 GO:0006801 superoxide metabolic process 1/147 74/18722 0.442596255269949 0.511714495366222 SOD2 1 GO:0007040 lysosome organization 1/147 74/18722 0.442596255269949 0.511714495366222 SRPX 1 GO:0030968 endoplasmic reticulum unfolded protein response 1/147 74/18722 0.442596255269949 0.511714495366222 PPP1R15A 1 GO:0046323 glucose import 1/147 74/18722 0.442596255269949 0.511714495366222 IRS2 1 GO:0048844 artery morphogenesis 1/147 74/18722 0.442596255269949 0.511714495366222 VEGFA 1 GO:0051881 regulation of mitochondrial membrane potential 1/147 74/18722 0.442596255269949 0.511714495366222 GCLC 1 GO:0080171 lytic vacuole organization 1/147 74/18722 0.442596255269949 0.511714495366222 SRPX 1 GO:0120192 tight junction assembly 1/147 74/18722 0.442596255269949 0.511714495366222 GJA1 1 GO:0008380 RNA splicing 4/147 434/18722 0.444690089485502 0.51373814509507 PPARGC1A/HSPA1A/DDX41/RBM15B 4 GO:0042391 regulation of membrane potential 4/147 434/18722 0.444690089485502 0.51373814509507 SNCA/GJA1/GCLC/SOD2 4 GO:0006278 RNA-dependent DNA biosynthetic process 1/147 75/18722 0.446990203708136 0.515201425545678 MAP3K4 1 GO:0008088 axo-dendritic transport 1/147 75/18722 0.446990203708136 0.515201425545678 HIF1A 1 GO:0033077 T cell differentiation in thymus 1/147 75/18722 0.446990203708136 0.515201425545678 SHH 1 GO:0034121 regulation of toll-like receptor signaling pathway 1/147 75/18722 0.446990203708136 0.515201425545678 SLC15A4 1 GO:0036465 synaptic vesicle recycling 1/147 75/18722 0.446990203708136 0.515201425545678 SNCA 1 GO:1902369 negative regulation of RNA catabolic process 1/147 75/18722 0.446990203708136 0.515201425545678 TOB1 1 GO:0046394 carboxylic acid biosynthetic process 3/147 314/18722 0.448767850336187 0.51705109412771 MCAT/PRKAA2/MTAP 3 GO:0006809 nitric oxide biosynthetic process 1/147 76/18722 0.451349748946239 0.518203466348774 SMAD3 1 GO:0008652 cellular amino acid biosynthetic process 1/147 76/18722 0.451349748946239 0.518203466348774 MTAP 1 GO:0009123 nucleoside monophosphate metabolic process 1/147 76/18722 0.451349748946239 0.518203466348774 AK4 1 GO:0021536 diencephalon development 1/147 76/18722 0.451349748946239 0.518203466348774 SHH 1 GO:0045685 regulation of glial cell differentiation 1/147 76/18722 0.451349748946239 0.518203466348774 SHH 1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 1/147 76/18722 0.451349748946239 0.518203466348774 BDKRB2 1 GO:0086001 cardiac muscle cell action potential 1/147 76/18722 0.451349748946239 0.518203466348774 GJA1 1 GO:0140029 exocytic process 1/147 76/18722 0.451349748946239 0.518203466348774 SNCA 1 GO:0140115 export across plasma membrane 1/147 76/18722 0.451349748946239 0.518203466348774 GJA1 1 GO:0002285 lymphocyte activation involved in immune response 2/147 194/18722 0.451500579506822 0.518203466348774 SLC15A4/HLA-F 2 GO:0016053 organic acid biosynthetic process 3/147 316/18722 0.452869758119292 0.519575545276103 MCAT/PRKAA2/MTAP 3 GO:0050804 modulation of chemical synaptic transmission 4/147 439/18722 0.453385314516372 0.519967590382848 SNCA/ATAD1/SLC30A1/PACSIN2 4 GO:0030705 cytoskeleton-dependent intracellular transport 2/147 195/18722 0.454128708690139 0.520620531886626 IFT46/HIF1A 2 GO:0010506 regulation of autophagy 3/147 317/18722 0.45491610754575 0.521194798903298 SNCA/PRKAA2/HIF1A 3 GO:0099177 regulation of trans-synaptic signaling 4/147 440/18722 0.455119286685728 0.521194798903298 SNCA/ATAD1/SLC30A1/PACSIN2 4 GO:0000380 alternative mRNA splicing, via spliceosome 1/147 77/18722 0.4556751585196 0.521194798903298 RBM15B 1 GO:0002200 somatic diversification of immune receptors 1/147 77/18722 0.4556751585196 0.521194798903298 SLC15A4 1 GO:0010827 regulation of glucose transmembrane transport 1/147 77/18722 0.4556751585196 0.521194798903298 IRS2 1 GO:0031016 pancreas development 1/147 77/18722 0.4556751585196 0.521194798903298 SHH 1 GO:0031032 actomyosin structure organization 2/147 196/18722 0.456749710075221 0.522224152459857 EPB41L3/SMAD3 2 GO:0042594 response to starvation 2/147 197/18722 0.459363533139133 0.524899043651618 PPARGC1A/PRKAA2 2 GO:0032371 regulation of sterol transport 1/147 78/18722 0.459966697897322 0.524899043651618 SHH 1 GO:0032374 regulation of cholesterol transport 1/147 78/18722 0.459966697897322 0.524899043651618 SHH 1 GO:0043297 apical junction assembly 1/147 78/18722 0.459966697897322 0.524899043651618 GJA1 1 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 1/147 78/18722 0.459966697897322 0.524899043651618 VEGFA 1 GO:0016042 lipid catabolic process 3/147 320/18722 0.461036291758321 0.525918973550396 MCAT/LPIN3/IRS2 3 GO:0001895 retina homeostasis 1/147 79/18722 0.46422463049811 0.528548104232908 IGKC 1 GO:0032272 negative regulation of protein polymerization 1/147 79/18722 0.46422463049811 0.528548104232908 SNCA 1 GO:0050772 positive regulation of axonogenesis 1/147 79/18722 0.46422463049811 0.528548104232908 VEGFA 1 GO:0051279 regulation of release of sequestered calcium ion into cytosol 1/147 79/18722 0.46422463049811 0.528548104232908 SNCA 1 GO:0060420 regulation of heart growth 1/147 79/18722 0.46422463049811 0.528548104232908 GJA1 1 GO:0099003 vesicle-mediated transport in synapse 2/147 200/18722 0.467161445366682 0.531689453231258 SNCA/DNAJC5 2 GO:0007422 peripheral nervous system development 1/147 80/18722 0.468449217706004 0.532142654826684 NDRG1 1 GO:0021766 hippocampus development 1/147 80/18722 0.468449217706004 0.532142654826684 TSKU 1 GO:0048145 regulation of fibroblast proliferation 1/147 80/18722 0.468449217706004 0.532142654826684 MYC 1 GO:0051303 establishment of chromosome localization 1/147 80/18722 0.468449217706004 0.532142654826684 GEM 1 GO:0120193 tight junction organization 1/147 80/18722 0.468449217706004 0.532142654826684 GJA1 1 GO:0008544 epidermis development 3/147 324/18722 0.469151174165244 0.532737722827731 SHH/STK4/MAFF 3 GO:0009913 epidermal cell differentiation 2/147 202/18722 0.472323289797027 0.534468200449144 STK4/MAFF 2 GO:0017157 regulation of exocytosis 2/147 202/18722 0.472323289797027 0.534468200449144 SNCA/HLA-F 2 GO:1903046 meiotic cell cycle process 2/147 202/18722 0.472323289797027 0.534468200449144 MOV10L1/YTHDF2 2 GO:0001942 hair follicle development 1/147 81/18722 0.472640718885986 0.534468200449144 SHH 1 GO:0001960 negative regulation of cytokine-mediated signaling pathway 1/147 81/18722 0.472640718885986 0.534468200449144 YTHDF2 1 GO:0008589 regulation of smoothened signaling pathway 1/147 81/18722 0.472640718885986 0.534468200449144 SHH 1 GO:0010833 telomere maintenance via telomere lengthening 1/147 81/18722 0.472640718885986 0.534468200449144 MAP3K4 1 GO:0021954 central nervous system neuron development 1/147 81/18722 0.472640718885986 0.534468200449144 TSKU 1 GO:0046209 nitric oxide metabolic process 1/147 81/18722 0.472640718885986 0.534468200449144 SMAD3 1 GO:0048144 fibroblast proliferation 1/147 81/18722 0.472640718885986 0.534468200449144 MYC 1 GO:0048708 astrocyte differentiation 1/147 81/18722 0.472640718885986 0.534468200449144 SHH 1 GO:0001910 regulation of leukocyte mediated cytotoxicity 1/147 82/18722 0.476799391399465 0.537342494225999 HLA-F 1 GO:0002312 B cell activation involved in immune response 1/147 82/18722 0.476799391399465 0.537342494225999 SLC15A4 1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 1/147 82/18722 0.476799391399465 0.537342494225999 STK4 1 GO:0016575 histone deacetylation 1/147 82/18722 0.476799391399465 0.537342494225999 VEGFA 1 GO:0046889 positive regulation of lipid biosynthetic process 1/147 82/18722 0.476799391399465 0.537342494225999 PPARGC1A 1 GO:0050000 chromosome localization 1/147 82/18722 0.476799391399465 0.537342494225999 GEM 1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 1/147 82/18722 0.476799391399465 0.537342494225999 NOP14 1 GO:2001057 reactive nitrogen species metabolic process 1/147 82/18722 0.476799391399465 0.537342494225999 SMAD3 1 GO:2001252 positive regulation of chromosome organization 1/147 82/18722 0.476799391399465 0.537342494225999 MAP3K4 1 GO:0050886 endocrine process 1/147 83/18722 0.480925490619652 0.54151030744822 GJA1 1 GO:0051899 membrane depolarization 1/147 83/18722 0.480925490619652 0.54151030744822 GCLC 1 GO:0048638 regulation of developmental growth 3/147 330/18722 0.4812217977925 0.54151030744822 STK4/VEGFA/GJA1 3 GO:0070371 ERK1 and ERK2 cascade 3/147 330/18722 0.4812217977925 0.54151030744822 TPBG/CTSH/MYC 3 GO:0017038 protein import 2/147 206/18722 0.482557171089144 0.542808762214227 SHH/SMAD3 2 GO:0019216 regulation of lipid metabolic process 3/147 331/18722 0.483221279061738 0.543351445741977 PPARGC1A/SNCA/IRS2 3 GO:0002088 lens development in camera-type eye 1/147 84/18722 0.48501926994681 0.543941745935849 SMAD3 1 GO:0006970 response to osmotic stress 1/147 84/18722 0.48501926994681 0.543941745935849 BDKRB2 1 GO:0009953 dorsal/ventral pattern formation 1/147 84/18722 0.48501926994681 0.543941745935849 SHH 1 GO:0015844 monoamine transport 1/147 84/18722 0.48501926994681 0.543941745935849 SNCA 1 GO:0022404 molting cycle process 1/147 84/18722 0.48501926994681 0.543941745935849 SHH 1 GO:0022405 hair cycle process 1/147 84/18722 0.48501926994681 0.543941745935849 SHH 1 GO:0045445 myoblast differentiation 1/147 84/18722 0.48501926994681 0.543941745935849 SHH 1 GO:0010507 negative regulation of autophagy 1/147 85/18722 0.489080980823397 0.546856528464591 SNCA 1 GO:0032092 positive regulation of protein binding 1/147 85/18722 0.489080980823397 0.546856528464591 STK4 1 GO:0055013 cardiac muscle cell development 1/147 85/18722 0.489080980823397 0.546856528464591 VEGFA 1 GO:0072384 organelle transport along microtubule 1/147 85/18722 0.489080980823397 0.546856528464591 HIF1A 1 GO:0097006 regulation of plasma lipoprotein particle levels 1/147 85/18722 0.489080980823397 0.546856528464591 CNPY2 1 GO:0097194 execution phase of apoptosis 1/147 85/18722 0.489080980823397 0.546856528464591 PLSCR1 1 GO:0098773 skin epidermis development 1/147 85/18722 0.489080980823397 0.546856528464591 SHH 1 GO:2000779 regulation of double-strand break repair 1/147 85/18722 0.489080980823397 0.546856528464591 PARP9 1 GO:0007623 circadian rhythm 2/147 210/18722 0.492669168966354 0.550539238668346 PPARGC1A/PRKAA2 2 GO:0006493 protein O-linked glycosylation 1/147 86/18722 0.49311087274908 0.550539238668346 GALNT15 1 GO:0032413 negative regulation of ion transmembrane transporter activity 1/147 86/18722 0.49311087274908 0.550539238668346 GEM 1 GO:0060761 negative regulation of response to cytokine stimulus 1/147 86/18722 0.49311087274908 0.550539238668346 YTHDF2 1 GO:0019646 aerobic electron transport chain 1/147 87/18722 0.497109193295651 0.55438240012949 SNCA 1 GO:0019915 lipid storage 1/147 87/18722 0.497109193295651 0.55438240012949 PLIN2 1 GO:0150104 transport across blood-brain barrier 1/147 87/18722 0.497109193295651 0.55438240012949 SLC7A2 1 GO:0030101 natural killer cell activation 1/147 88/18722 0.501076188121813 0.558182077717819 HLA-F 1 GO:0070098 chemokine-mediated signaling pathway 1/147 88/18722 0.501076188121813 0.558182077717819 HIF1A 1 GO:1901657 glycosyl compound metabolic process 1/147 88/18722 0.501076188121813 0.558182077717819 MTAP 1 GO:0072330 monocarboxylic acid biosynthetic process 2/147 214/18722 0.502656953616855 0.559734530256148 MCAT/PRKAA2 2 GO:0014910 regulation of smooth muscle cell migration 1/147 89/18722 0.50501210098787 0.562147820638153 PPARGC1A 1 GO:0002377 immunoglobulin production 2/147 216/18722 0.507603609224068 0.564813085991439 IGKC/SLC15A4 2 GO:0006400 tRNA modification 1/147 90/18722 0.508917173770287 0.564813085991439 DUS1L 1 GO:0034644 cellular response to UV 1/147 90/18722 0.508917173770287 0.564813085991439 MYC 1 GO:0035304 regulation of protein dephosphorylation 1/147 90/18722 0.508917173770287 0.564813085991439 PPP1R15A 1 GO:0045638 negative regulation of myeloid cell differentiation 1/147 90/18722 0.508917173770287 0.564813085991439 MYC 1 GO:0046849 bone remodeling 1/147 90/18722 0.508917173770287 0.564813085991439 GJA1 1 GO:0048477 oogenesis 1/147 90/18722 0.508917173770287 0.564813085991439 YTHDF2 1 GO:0061097 regulation of protein tyrosine kinase activity 1/147 90/18722 0.508917173770287 0.564813085991439 SH3BP5 1 GO:0007163 establishment or maintenance of cell polarity 2/147 218/18722 0.512518454632007 0.567638717472311 SHH/GJA1 2 GO:0007059 chromosome segregation 3/147 346/18722 0.512765426319772 0.567638717472311 PLSCR1/GEM/TLK1 3 GO:0051492 regulation of stress fiber assembly 1/147 91/18722 0.512791646476157 0.567638717472311 SMAD3 1 GO:0051952 regulation of amine transport 1/147 91/18722 0.512791646476157 0.567638717472311 SNCA 1 GO:0051983 regulation of chromosome segregation 1/147 91/18722 0.512791646476157 0.567638717472311 PLSCR1 1 GO:0055006 cardiac cell development 1/147 91/18722 0.512791646476157 0.567638717472311 VEGFA 1 GO:0060191 regulation of lipase activity 1/147 91/18722 0.512791646476157 0.567638717472311 SNCA 1 GO:0006936 muscle contraction 3/147 347/18722 0.514703893100678 0.569411076590124 BDKRB2/MYOF/GJA1 3 GO:0034764 positive regulation of transmembrane transport 2/147 219/18722 0.514963879029183 0.569411076590124 SNCA/IRS2 2 GO:2001020 regulation of response to DNA damage stimulus 2/147 219/18722 0.514963879029183 0.569411076590124 PARP9/MYC 2 GO:0034502 protein localization to chromosome 1/147 92/18722 0.516635757257543 0.57062686482914 PIH1D1 1 GO:0035249 synaptic transmission, glutamatergic 1/147 92/18722 0.516635757257543 0.57062686482914 ATAD1 1 GO:1903312 negative regulation of mRNA metabolic process 1/147 92/18722 0.516635757257543 0.57062686482914 TOB1 1 GO:0008406 gonad development 2/147 221/18722 0.519830600239573 0.57394364168201 VEGFA/CEBPB 2 GO:0051591 response to cAMP 1/147 93/18722 0.52044974242572 0.574203312281567 FOS 1 GO:1901019 regulation of calcium ion transmembrane transporter activity 1/147 93/18722 0.52044974242572 0.574203312281567 GEM 1 GO:0002042 cell migration involved in sprouting angiogenesis 1/147 94/18722 0.524233836465305 0.577212486596841 VEGFA 1 GO:0002690 positive regulation of leukocyte chemotaxis 1/147 94/18722 0.524233836465305 0.577212486596841 VEGFA 1 GO:0014020 primary neural tube formation 1/147 94/18722 0.524233836465305 0.577212486596841 HIF1A 1 GO:0048704 embryonic skeletal system morphogenesis 1/147 94/18722 0.524233836465305 0.577212486596841 SMAD3 1 GO:1990830 cellular response to leukemia inhibitory factor 1/147 94/18722 0.524233836465305 0.577212486596841 SOCS3 1 GO:0006887 exocytosis 3/147 352/18722 0.524335114036649 0.577212486596841 SNCA/DNAJC5/HLA-F 3 GO:0006066 alcohol metabolic process 3/147 353/18722 0.526248968935321 0.579106205329486 SNCA/PRKAA2/TSKU 3 GO:0032984 protein-containing complex disassembly 2/147 224/18722 0.52706999684779 0.579315084995009 ZFAND1/MYC 2 GO:0002532 production of molecular mediator involved in inflammatory response 1/147 95/18722 0.527988272048276 0.579315084995009 HIF1A 1 GO:0008593 regulation of Notch signaling pathway 1/147 95/18722 0.527988272048276 0.579315084995009 YTHDF2 1 GO:0030516 regulation of axon extension 1/147 95/18722 0.527988272048276 0.579315084995009 VEGFA 1 GO:0042773 ATP synthesis coupled electron transport 1/147 95/18722 0.527988272048276 0.579315084995009 SNCA 1 GO:0042775 mitochondrial ATP synthesis coupled electron transport 1/147 95/18722 0.527988272048276 0.579315084995009 SNCA 1 GO:0050764 regulation of phagocytosis 1/147 95/18722 0.527988272048276 0.579315084995009 PLSCR1 1 GO:1990823 response to leukemia inhibitory factor 1/147 95/18722 0.527988272048276 0.579315084995009 SOCS3 1 GO:0006637 acyl-CoA metabolic process 1/147 96/18722 0.531713280047895 0.581212977503903 SNCA 1 GO:0035383 thioester metabolic process 1/147 96/18722 0.531713280047895 0.581212977503903 SNCA 1 GO:0042472 inner ear morphogenesis 1/147 96/18722 0.531713280047895 0.581212977503903 DLX5 1 GO:0042632 cholesterol homeostasis 1/147 96/18722 0.531713280047895 0.581212977503903 TSKU 1 GO:0044264 cellular polysaccharide metabolic process 1/147 96/18722 0.531713280047895 0.581212977503903 IRS2 1 GO:0051304 chromosome separation 1/147 96/18722 0.531713280047895 0.581212977503903 PLSCR1 1 GO:0055017 cardiac muscle tissue growth 1/147 96/18722 0.531713280047895 0.581212977503903 GJA1 1 GO:1901655 cellular response to ketone 1/147 96/18722 0.531713280047895 0.581212977503903 PRKAA2 1 GO:1904035 regulation of epithelial cell apoptotic process 1/147 96/18722 0.531713280047895 0.581212977503903 PPARGC1A 1 GO:0006486 protein glycosylation 2/147 226/18722 0.531855539762014 0.581212977503903 B4GALT1/GALNT15 2 GO:0043413 macromolecule glycosylation 2/147 226/18722 0.531855539762014 0.581212977503903 B4GALT1/GALNT15 2 GO:0045137 development of primary sexual characteristics 2/147 227/18722 0.534236031768578 0.583175171905043 VEGFA/CEBPB 2 GO:0046777 protein autophosphorylation 2/147 227/18722 0.534236031768578 0.583175171905043 STK4/VEGFA 2 GO:0071826 ribonucleoprotein complex subunit organization 2/147 227/18722 0.534236031768578 0.583175171905043 ZFAND1/PIH1D1 2 GO:0055092 sterol homeostasis 1/147 97/18722 0.535409089552511 0.58360371240946 TSKU 1 GO:0070252 actin-mediated cell contraction 1/147 97/18722 0.535409089552511 0.58360371240946 GJA1 1 GO:1990868 response to chemokine 1/147 97/18722 0.535409089552511 0.58360371240946 HIF1A 1 GO:1990869 cellular response to chemokine 1/147 97/18722 0.535409089552511 0.58360371240946 HIF1A 1 GO:0048285 organelle fission 4/147 488/18722 0.535854768072179 0.583876725429467 PPARGC1A/HSPA1A/MOV10L1/HSPA1B 4 GO:0009306 protein secretion 3/147 359/18722 0.537643473135913 0.585612391897129 IRS2/GJA1/HIF1A 3 GO:0032642 regulation of chemokine production 1/147 98/18722 0.539075927879264 0.586531866237497 HIF1A 1 GO:0043473 pigmentation 1/147 98/18722 0.539075927879264 0.586531866237497 MLPH 1 GO:0061337 cardiac conduction 1/147 98/18722 0.539075927879264 0.586531866237497 GJA1 1 GO:0035592 establishment of protein localization to extracellular region 3/147 360/18722 0.539527586106494 0.586809821834372 IRS2/GJA1/HIF1A 3 GO:0034765 regulation of ion transmembrane transport 4/147 491/18722 0.540710463932394 0.587882587285274 PPARGC1A/SNCA/GEM/SLC30A1 4 GO:0003300 cardiac muscle hypertrophy 1/147 99/18722 0.542714020587691 0.588349994772665 SMAD3 1 GO:0007631 feeding behavior 1/147 99/18722 0.542714020587691 0.588349994772665 FOS 1 GO:0015837 amine transport 1/147 99/18722 0.542714020587691 0.588349994772665 SNCA 1 GO:0021510 spinal cord development 1/147 99/18722 0.542714020587691 0.588349994772665 SHH 1 GO:0021549 cerebellum development 1/147 99/18722 0.542714020587691 0.588349994772665 PPARGC1A 1 GO:0032602 chemokine production 1/147 99/18722 0.542714020587691 0.588349994772665 HIF1A 1 GO:0042100 B cell proliferation 1/147 99/18722 0.542714020587691 0.588349994772665 IRS2 1 GO:0060291 long-term synaptic potentiation 1/147 99/18722 0.542714020587691 0.588349994772665 SNCA 1 GO:0006641 triglyceride metabolic process 1/147 100/18722 0.546323591493217 0.591405668532831 LPIN3 1 GO:0019218 regulation of steroid metabolic process 1/147 100/18722 0.546323591493217 0.591405668532831 PPARGC1A 1 GO:0060079 excitatory postsynaptic potential 1/147 100/18722 0.546323591493217 0.591405668532831 SNCA 1 GO:0110020 regulation of actomyosin structure organization 1/147 100/18722 0.546323591493217 0.591405668532831 SMAD3 1 GO:0007160 cell-matrix adhesion 2/147 233/18722 0.548345901680432 0.593380098381393 VEGFA/SMAD3 2 GO:0048024 regulation of mRNA splicing, via spliceosome 1/147 101/18722 0.549904862680549 0.594851878581382 RBM15B 1 GO:0060560 developmental growth involved in morphogenesis 2/147 234/18722 0.550668544575706 0.595462623581322 SHH/VEGFA 2 GO:0002699 positive regulation of immune effector process 2/147 235/18722 0.552982861399461 0.597614816267239 HLA-F/CD55 2 GO:0010522 regulation of calcium ion transport into cytosol 1/147 102/18722 0.553458054516968 0.597614816267239 SNCA 1 GO:0014897 striated muscle hypertrophy 1/147 102/18722 0.553458054516968 0.597614816267239 SMAD3 1 GO:0062014 negative regulation of small molecule metabolic process 1/147 102/18722 0.553458054516968 0.597614816267239 PPARGC1A 1 GO:0071692 protein localization to extracellular region 3/147 368/18722 0.554442893319347 0.598462177523698 IRS2/GJA1/HIF1A 3 GO:0014013 regulation of gliogenesis 1/147 103/18722 0.556983385665518 0.600987484316582 SHH 1 GO:1901617 organic hydroxy compound biosynthetic process 2/147 237/18722 0.557586464532795 0.601421246093613 SNCA/PRKAA2 2 GO:0006892 post-Golgi vesicle-mediated transport 1/147 104/18722 0.560481073098096 0.603455323843199 VPS13A 1 GO:0014896 muscle hypertrophy 1/147 104/18722 0.560481073098096 0.603455323843199 SMAD3 1 GO:0032963 collagen metabolic process 1/147 104/18722 0.560481073098096 0.603455323843199 HIF1A 1 GO:0060419 heart growth 1/147 104/18722 0.560481073098096 0.603455323843199 GJA1 1 GO:1903076 regulation of protein localization to plasma membrane 1/147 104/18722 0.560481073098096 0.603455323843199 DAB2 1 GO:0032231 regulation of actin filament bundle assembly 1/147 105/18722 0.56395133210844 0.606754832495088 SMAD3 1 GO:0040029 regulation of gene expression, epigenetic 1/147 105/18722 0.56395133210844 0.606754832495088 RBM15B 1 GO:0070085 glycosylation 2/147 240/18722 0.564429115382567 0.607050515681142 B4GALT1/GALNT15 2 GO:0071824 protein-DNA complex subunit organization 2/147 241/18722 0.566693222124004 0.608925934549025 MYC/PIH1D1 2 GO:0001824 blastocyst development 1/147 106/18722 0.567394376325019 0.608925934549025 PSMC4 1 GO:0030038 contractile actin filament bundle assembly 1/147 106/18722 0.567394376325019 0.608925934549025 SMAD3 1 GO:0042116 macrophage activation 1/147 106/18722 0.567394376325019 0.608925934549025 SNCA 1 GO:0043149 stress fiber assembly 1/147 106/18722 0.567394376325019 0.608925934549025 SMAD3 1 GO:0099565 chemical synaptic transmission, postsynaptic 1/147 106/18722 0.567394376325019 0.608925934549025 SNCA 1 GO:0000018 regulation of DNA recombination 1/147 107/18722 0.570810417723828 0.611276032728955 SLC15A4 1 GO:0005976 polysaccharide metabolic process 1/147 107/18722 0.570810417723828 0.611276032728955 IRS2 1 GO:0010927 cellular component assembly involved in morphogenesis 1/147 107/18722 0.570810417723828 0.611276032728955 EPB41L3 1 GO:0021761 limbic system development 1/147 107/18722 0.570810417723828 0.611276032728955 TSKU 1 GO:0071868 cellular response to monoamine stimulus 1/147 107/18722 0.570810417723828 0.611276032728955 SNCA 1 GO:0071870 cellular response to catecholamine stimulus 1/147 107/18722 0.570810417723828 0.611276032728955 SNCA 1 GO:0022037 metencephalon development 1/147 108/18722 0.574199666641078 0.614685469908183 PPARGC1A 1 GO:0031668 cellular response to extracellular stimulus 2/147 246/18722 0.577887533521075 0.61841202603275 PRKAA2/FOS 2 GO:0007018 microtubule-based movement 3/147 382/18722 0.579849731490566 0.618756329478168 IFT46/VPS13A/HIF1A 3 GO:0032535 regulation of cellular component size 3/147 382/18722 0.579849731490566 0.618756329478168 DEPTOR/PPP1R15A/VEGFA 3 GO:0003014 renal system process 1/147 110/18722 0.580898620252323 0.618756329478168 GJA1 1 GO:0006939 smooth muscle contraction 1/147 110/18722 0.580898620252323 0.618756329478168 BDKRB2 1 GO:0009063 cellular amino acid catabolic process 1/147 110/18722 0.580898620252323 0.618756329478168 ALDH5A1 1 GO:0018958 phenol-containing compound metabolic process 1/147 110/18722 0.580898620252323 0.618756329478168 SNCA 1 GO:0030317 flagellated sperm motility 1/147 110/18722 0.580898620252323 0.618756329478168 VPS13A 1 GO:0032611 interleukin-1 beta production 1/147 110/18722 0.580898620252323 0.618756329478168 SMAD3 1 GO:0032651 regulation of interleukin-1 beta production 1/147 110/18722 0.580898620252323 0.618756329478168 SMAD3 1 GO:0061387 regulation of extent of cell growth 1/147 110/18722 0.580898620252323 0.618756329478168 VEGFA 1 GO:0097722 sperm motility 1/147 110/18722 0.580898620252323 0.618756329478168 VPS13A 1 GO:1904659 glucose transmembrane transport 1/147 110/18722 0.580898620252323 0.618756329478168 IRS2 1 GO:1905954 positive regulation of lipid localization 1/147 110/18722 0.580898620252323 0.618756329478168 PLIN2 1 GO:0015718 monocarboxylic acid transport 1/147 111/18722 0.584208737532728 0.622060638647344 BDKRB2 1 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 2/147 249/18722 0.584502895049493 0.622152369783998 SLC35B2/GJA1 2 GO:0000956 nuclear-transcribed mRNA catabolic process 1/147 112/18722 0.587492887529111 0.624890194381071 TOB1 1 GO:0010633 negative regulation of epithelial cell migration 1/147 112/18722 0.587492887529111 0.624890194381071 MCC 1 GO:0009100 glycoprotein metabolic process 3/147 387/18722 0.588702685294088 0.625954401604912 B4GALT1/HIF1A/GALNT15 3 GO:0090257 regulation of muscle system process 2/147 252/18722 0.591042171365473 0.628218597922576 PPARGC1A/SMAD3 2 GO:0007041 lysosomal transport 1/147 114/18722 0.593984093401593 0.630225762101513 HSPA1A 1 GO:0008645 hexose transmembrane transport 1/147 114/18722 0.593984093401593 0.630225762101513 IRS2 1 GO:0019751 polyol metabolic process 1/147 114/18722 0.593984093401593 0.630225762101513 SNCA 1 GO:0021987 cerebral cortex development 1/147 114/18722 0.593984093401593 0.630225762101513 HIF1A 1 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1/147 114/18722 0.593984093401593 0.630225762101513 DAB2 1 GO:0042471 ear morphogenesis 1/147 115/18722 0.597191549241552 0.633404228291306 DLX5 1 GO:0006338 chromatin remodeling 2/147 255/18722 0.597505281767647 0.633512335259494 MYC/PIH1D1 2 GO:1903522 regulation of blood circulation 2/147 256/18722 0.599642718717176 0.635553285500735 BDKRB2/GJA1 2 GO:0015749 monosaccharide transmembrane transport 1/147 116/18722 0.600373837749184 0.635877531412113 IRS2 1 GO:0033559 unsaturated fatty acid metabolic process 1/147 116/18722 0.600373837749184 0.635877531412113 PTGR2 1 GO:1903828 negative regulation of cellular protein localization 1/147 117/18722 0.603531155058163 0.638995286647421 DAB2 1 GO:0045165 cell fate commitment 2/147 258/18722 0.603892190565754 0.639151288741037 SHH/DKK1 2 GO:0030203 glycosaminoglycan metabolic process 1/147 118/18722 0.606663695784121 0.64163052124834 IDS 1 GO:0034219 carbohydrate transmembrane transport 1/147 118/18722 0.606663695784121 0.64163052124834 IRS2 1 GO:0090150 establishment of protein localization to membrane 2/147 260/18722 0.608107797430417 0.642930513295997 ATAD1/RABGEF1 2 GO:0031398 positive regulation of protein ubiquitination 1/147 119/18722 0.60977165303631 0.644461842484666 DCUN1D1 1 GO:0090305 nucleic acid phosphodiester bond hydrolysis 2/147 261/18722 0.610202905048587 0.644689823030846 PLSCR1/NOP14 2 GO:0048675 axon extension 1/147 120/18722 0.612855218429186 0.64680661902671 VEGFA 1 GO:0051897 positive regulation of protein kinase B signaling 1/147 120/18722 0.612855218429186 0.64680661902671 TPBG 1 GO:0071901 negative regulation of protein serine/threonine kinase activity 1/147 120/18722 0.612855218429186 0.64680661902671 HEXIM1 1 GO:0043588 skin development 2/147 263/18722 0.614367740086088 0.64817421890564 SHH/STK4 2 GO:0002224 toll-like receptor signaling pathway 1/147 121/18722 0.615914582093894 0.649119279437223 SLC15A4 1 GO:0003206 cardiac chamber morphogenesis 1/147 121/18722 0.615914582093894 0.649119279437223 HIF1A 1 GO:0045931 positive regulation of mitotic cell cycle 1/147 121/18722 0.615914582093894 0.649119279437223 CCDC57 1 GO:0002688 regulation of leukocyte chemotaxis 1/147 122/18722 0.61894993268968 0.651858890378462 VEGFA 1 GO:0051928 positive regulation of calcium ion transport 1/147 122/18722 0.61894993268968 0.651858890378462 SNCA 1 GO:0003231 cardiac ventricle development 1/147 123/18722 0.621961457415197 0.654109254264716 HIF1A 1 GO:0006690 icosanoid metabolic process 1/147 123/18722 0.621961457415197 0.654109254264716 PTGR2 1 GO:0030168 platelet activation 1/147 123/18722 0.621961457415197 0.654109254264716 PLSCR1 1 GO:0071482 cellular response to light stimulus 1/147 123/18722 0.621961457415197 0.654109254264716 MYC 1 GO:0032412 regulation of ion transmembrane transporter activity 2/147 267/18722 0.622595983409516 0.654546427549336 PPARGC1A/GEM 2 GO:0051053 negative regulation of DNA metabolic process 1/147 125/18722 0.627913770814404 0.65944174455965 GJA1 1 GO:0060294 cilium movement involved in cell motility 1/147 125/18722 0.627913770814404 0.65944174455965 VPS13A 1 GO:1904375 regulation of protein localization to cell periphery 1/147 125/18722 0.627913770814404 0.65944174455965 DAB2 1 GO:0006911 phagocytosis, engulfment 1/147 127/18722 0.633772991093604 0.664894779502269 IGKC 1 GO:0008033 tRNA processing 1/147 127/18722 0.633772991093604 0.664894779502269 DUS1L 1 GO:0030048 actin filament-based movement 1/147 127/18722 0.633772991093604 0.664894779502269 GJA1 1 GO:0006639 acylglycerol metabolic process 1/147 128/18722 0.636668144108352 0.667229999659453 LPIN3 1 GO:0032612 interleukin-1 production 1/147 128/18722 0.636668144108352 0.667229999659453 SMAD3 1 GO:0032652 regulation of interleukin-1 production 1/147 128/18722 0.636668144108352 0.667229999659453 SMAD3 1 GO:0002366 leukocyte activation involved in immune response 2/147 275/18722 0.638647894776401 0.668836083079907 SLC15A4/HLA-F 2 GO:0043270 positive regulation of ion transport 2/147 275/18722 0.638647894776401 0.668836083079907 SNCA/CEBPB 2 GO:0006022 aminoglycan metabolic process 1/147 129/18722 0.63954056439533 0.669302249162502 IDS 1 GO:0007127 meiosis I 1/147 129/18722 0.63954056439533 0.669302249162502 MOV10L1 1 GO:0006282 regulation of DNA repair 1/147 130/18722 0.64239042923876 0.67134513412059 PARP9 1 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 1/147 130/18722 0.64239042923876 0.67134513412059 COPB2 1 GO:0007098 centrosome cycle 1/147 130/18722 0.64239042923876 0.67134513412059 CCDC57 1 GO:0030534 adult behavior 1/147 130/18722 0.64239042923876 0.67134513412059 SNCA 1 GO:0007281 germ cell development 2/147 278/18722 0.644528854975281 0.673124095716183 MOV10L1/YTHDF2 2 GO:0006612 protein targeting to membrane 1/147 131/18722 0.645217914549748 0.673124095716183 RABGEF1 1 GO:0019827 stem cell population maintenance 1/147 131/18722 0.645217914549748 0.673124095716183 MYC 1 GO:0046683 response to organophosphorus 1/147 131/18722 0.645217914549748 0.673124095716183 FOS 1 GO:0050853 B cell receptor signaling pathway 1/147 131/18722 0.645217914549748 0.673124095716183 IGKC 1 GO:0002263 cell activation involved in immune response 2/147 279/18722 0.646472454112631 0.674197737186499 SLC15A4/HLA-F 2 GO:0006470 protein dephosphorylation 2/147 281/18722 0.650334629732403 0.677752918999866 PPP2R1B/PPP1R15A 2 GO:0007249 I-kappaB kinase/NF-kappaB signaling 2/147 281/18722 0.650334629732403 0.677752918999866 SLC35B2/GJA1 2 GO:0001508 action potential 1/147 134/18722 0.653567832023677 0.680648114757249 GJA1 1 GO:0098727 maintenance of cell number 1/147 134/18722 0.653567832023677 0.680648114757249 MYC 1 GO:0002687 positive regulation of leukocyte migration 1/147 135/18722 0.656307531221682 0.683025687503149 VEGFA 1 GO:0061982 meiosis I cell cycle process 1/147 135/18722 0.656307531221682 0.683025687503149 MOV10L1 1 GO:0099024 plasma membrane invagination 1/147 136/18722 0.659025710212935 0.68537757275622 IGKC 1 GO:1903305 regulation of regulated secretory pathway 1/147 136/18722 0.659025710212935 0.68537757275622 HLA-F 1 GO:0140014 mitotic nuclear division 2/147 287/18722 0.661721756343632 0.686749516944682 HSPA1A/HSPA1B 2 GO:0000086 G2/M transition of mitotic cell cycle 1/147 137/18722 0.661722536888857 0.686749516944682 CCDC57 1 GO:0007586 digestion 1/147 137/18722 0.661722536888857 0.686749516944682 PPARGC1A 1 GO:0050684 regulation of mRNA processing 1/147 137/18722 0.661722536888857 0.686749516944682 RBM15B 1 GO:0060048 cardiac muscle contraction 1/147 137/18722 0.661722536888857 0.686749516944682 GJA1 1 GO:0060078 regulation of postsynaptic membrane potential 1/147 137/18722 0.661722536888857 0.686749516944682 SNCA 1 GO:0001539 cilium or flagellum-dependent cell motility 1/147 138/18722 0.664398177840019 0.688570668717774 VPS13A 1 GO:0007224 smoothened signaling pathway 1/147 138/18722 0.664398177840019 0.688570668717774 SHH 1 GO:0060285 cilium-dependent cell motility 1/147 138/18722 0.664398177840019 0.688570668717774 VPS13A 1 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 1/147 138/18722 0.664398177840019 0.688570668717774 DCUN1D1 1 GO:0030216 keratinocyte differentiation 1/147 139/18722 0.667052798366145 0.691082410776979 STK4 1 GO:0002429 immune response-activating cell surface receptor signaling pathway 2/147 291/18722 0.669147961632977 0.692533409427071 IGKC/PLSCR1 2 GO:0002757 immune response-activating signal transduction 2/147 291/18722 0.669147961632977 0.692533409427071 IGKC/PLSCR1 2 GO:0016236 macroautophagy 2/147 291/18722 0.669147961632977 0.692533409427071 PRKAA2/HIF1A 2 GO:0007292 female gamete generation 1/147 140/18722 0.669686562486049 0.692851092492484 YTHDF2 1 GO:0030183 B cell differentiation 1/147 141/18722 0.672299632947493 0.695314039469554 TPD52 1 GO:0000280 nuclear division 3/147 439/18722 0.673539572657671 0.696355638375076 HSPA1A/MOV10L1/HSPA1B 3 GO:0031023 microtubule organizing center organization 1/147 143/18722 0.677464337589398 0.700171331627467 CCDC57 1 GO:0010324 membrane invagination 1/147 144/18722 0.680016290997781 0.702566054015324 IGKC 1 GO:0048511 rhythmic process 2/147 298/18722 0.681828711376079 0.704195330015833 PPARGC1A/PRKAA2 2 GO:0010975 regulation of neuron projection development 3/147 445/18722 0.682461040765703 0.704605099389098 VEGFA/TSKU/SPOCK1 3 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/147 146/18722 0.685060188802021 0.706556905071326 RXFP1 1 GO:0042542 response to hydrogen peroxide 1/147 146/18722 0.685060188802021 0.706556905071326 SOD2 1 GO:0048813 dendrite morphogenesis 1/147 146/18722 0.685060188802021 0.706556905071326 TPBG 1 GO:0060041 retina development in camera-type eye 1/147 147/18722 0.687552445059886 0.708882924224101 HIF1A 1 GO:0044839 cell cycle G2/M phase transition 1/147 148/18722 0.690025112116478 0.711187150358507 CCDC57 1 GO:1904064 positive regulation of cation transmembrane transport 1/147 151/18722 0.697327101412269 0.718465504762003 SNCA 1 GO:0008643 carbohydrate transport 1/147 152/18722 0.699722929105575 0.720437618228838 IRS2 1 GO:0090501 RNA phosphodiester bond hydrolysis 1/147 152/18722 0.699722929105575 0.720437618228838 NOP14 1 GO:0120254 olefinic compound metabolic process 1/147 153/18722 0.702099920458375 0.722636222330006 PPARGC1A 1 GO:0060326 cell chemotaxis 2/147 310/18722 0.702647559793277 0.722951101252732 TPBG/VEGFA 2 GO:0050770 regulation of axonogenesis 1/147 154/18722 0.704458222558252 0.724564836200733 VEGFA 1 GO:0019932 second-messenger-mediated signaling 2/147 312/18722 0.706006098300666 0.725907267108042 CHERP/VEGFA 2 GO:0045787 positive regulation of cell cycle 2/147 313/18722 0.707673582097416 0.727371712733118 PLSCR1/CCDC57 2 GO:0022613 ribonucleoprotein complex biogenesis 3/147 463/18722 0.708144802688525 0.727606013342968 NOP14/YTHDF2/PIH1D1 3 GO:0009267 cellular response to starvation 1/147 156/18722 0.709119341654842 0.72832670908488 PRKAA2 1 GO:0006605 protein targeting 2/147 314/18722 0.709333234224091 0.72832670908488 VPS13A/RABGEF1 2 GO:0002768 immune response-regulating cell surface receptor signaling pathway 2/147 315/18722 0.710985073890254 0.729720349605761 IGKC/PLSCR1 2 GO:0007030 Golgi organization 1/147 157/18722 0.711422447158275 0.729720349605761 COG1 1 GO:0051017 actin filament bundle assembly 1/147 157/18722 0.711422447158275 0.729720349605761 SMAD3 1 GO:0009101 glycoprotein biosynthetic process 2/147 317/18722 0.714265393585564 0.732385256158527 B4GALT1/GALNT15 2 GO:0035637 multicellular organismal signaling 1/147 160/18722 0.718223655123443 0.736191553281089 GJA1 1 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2/147 320/18722 0.719127770169386 0.736613411156381 DDX41/RBM15B 2 GO:0000398 mRNA splicing, via spliceosome 2/147 320/18722 0.719127770169386 0.736613411156381 DDX41/RBM15B 2 GO:0003205 cardiac chamber development 1/147 161/18722 0.720455156184582 0.737467957613992 HIF1A 1 GO:0061572 actin filament bundle organization 1/147 161/18722 0.720455156184582 0.737467957613992 SMAD3 1 GO:0051494 negative regulation of cytoskeleton organization 1/147 162/18722 0.722669104357679 0.739481112259261 SNCA 1 GO:0000375 RNA splicing, via transesterification reactions 2/147 324/18722 0.725503326737772 0.74212737697424 DDX41/RBM15B 2 GO:0050806 positive regulation of synaptic transmission 1/147 164/18722 0.727044889503492 0.743450004958955 SNCA 1 GO:0032635 interleukin-6 production 1/147 165/18722 0.729206997556244 0.744896902216778 CEBPB 1 GO:0032675 regulation of interleukin-6 production 1/147 165/18722 0.729206997556244 0.744896902216778 CEBPB 1 GO:0046661 male sex differentiation 1/147 165/18722 0.729206997556244 0.744896902216778 SHH 1 GO:0030307 positive regulation of cell growth 1/147 166/18722 0.731352094897368 0.74657819653175 VEGFA 1 GO:1902904 negative regulation of supramolecular fiber organization 1/147 166/18722 0.731352094897368 0.74657819653175 SNCA 1 GO:0007254 JNK cascade 1/147 167/18722 0.733480314451695 0.748239979715218 SMAD3 1 GO:0034767 positive regulation of ion transmembrane transport 1/147 167/18722 0.733480314451695 0.748239979715218 SNCA 1 GO:0099173 postsynapse organization 1/147 168/18722 0.735591788112466 0.750138096912507 NDRG1 1 GO:0046890 regulation of lipid biosynthetic process 1/147 171/18722 0.741827037358522 0.756238810067941 PPARGC1A 1 GO:0007219 Notch signaling pathway 1/147 172/18722 0.743872826022653 0.757291906954988 YTHDF2 1 GO:0042770 signal transduction in response to DNA damage 1/147 172/18722 0.743872826022653 0.757291906954988 NDRG1 1 GO:1901136 carbohydrate derivative catabolic process 1/147 172/18722 0.743872826022653 0.757291906954988 IDS 1 GO:1990138 neuron projection extension 1/147 172/18722 0.743872826022653 0.757291906954988 VEGFA 1 GO:0060271 cilium assembly 2/147 337/18722 0.745389973557029 0.758578227597507 IFT46/CCDC57 2 GO:0048639 positive regulation of developmental growth 1/147 174/18722 0.747916224344263 0.760890281297174 VEGFA 1 GO:0003341 cilium movement 1/147 175/18722 0.749914084761634 0.762404156193762 VPS13A 1 GO:1905475 regulation of protein localization to membrane 1/147 175/18722 0.749914084761634 0.762404156193762 DAB2 1 GO:0006333 chromatin assembly or disassembly 1/147 177/18722 0.753862747725397 0.766158164609807 TLK1 1 GO:0006399 tRNA metabolic process 1/147 179/18722 0.757749481824683 0.769585297160485 DUS1L 1 GO:0006941 striated muscle contraction 1/147 179/18722 0.757749481824683 0.769585297160485 GJA1 1 GO:0007033 vacuole organization 1/147 180/18722 0.759669927608633 0.770750594802381 SRPX 1 GO:0010721 negative regulation of cell development 1/147 180/18722 0.759669927608633 0.770750594802381 VEGFA 1 GO:0043409 negative regulation of MAPK cascade 1/147 180/18722 0.759669927608633 0.770750594802381 MYC 1 GO:0042742 defense response to bacterium 2/147 350/18722 0.764038436146484 0.774919960160778 IGKC/CEBPB 2 GO:0051896 regulation of protein kinase B signaling 1/147 185/18722 0.769047683662353 0.779471915226736 TPBG 1 GO:0140013 meiotic nuclear division 1/147 185/18722 0.769047683662353 0.779471915226736 MOV10L1 1 GO:0071478 cellular response to radiation 1/147 186/18722 0.770879155340706 0.781063534425492 MYC 1 GO:0001818 negative regulation of cytokine production 2/147 357/18722 0.773584731643863 0.783539428495358 HLA-F/TSKU 2 GO:0044782 cilium organization 2/147 368/18722 0.787910038075888 0.797778918038247 IFT46/CCDC57 2 GO:0050900 leukocyte migration 2/147 369/18722 0.789172287182505 0.798786568853764 B4GALT1/VEGFA 2 GO:0048167 regulation of synaptic plasticity 1/147 198/18722 0.791763268111523 0.801138002341531 SNCA 1 GO:0065004 protein-DNA complex assembly 1/147 201/18722 0.796681776864665 0.805842135475893 PIH1D1 1 GO:0019722 calcium-mediated signaling 1/147 202/18722 0.798295500680922 0.807201434258499 CHERP 1 GO:0008016 regulation of heart contraction 1/147 206/18722 0.804624172344561 0.813325751768362 GJA1 1 GO:0022412 cellular process involved in reproduction in multicellular organism 2/147 384/18722 0.807331410702655 0.815786570747176 MOV10L1/YTHDF2 2 GO:0045786 negative regulation of cell cycle 2/147 385/18722 0.808491492822926 0.816682895992358 HEXIM1/SMAD3 2 GO:0002685 regulation of leukocyte migration 1/147 210/18722 0.810755584475507 0.818693434559838 VEGFA 1 GO:0043491 protein kinase B signaling 1/147 211/18722 0.812258335614341 0.81993408093908 TPBG 1 GO:0031669 cellular response to nutrient levels 1/147 215/18722 0.81815174002055 0.82560453927175 PRKAA2 1 GO:0070374 positive regulation of ERK1 and ERK2 cascade 1/147 217/18722 0.821029164410866 0.828228745616492 TPBG 1 GO:0022618 ribonucleoprotein complex assembly 1/147 220/18722 0.82526072470856 0.831936241187496 PIH1D1 1 GO:0097529 myeloid leukocyte migration 1/147 220/18722 0.82526072470856 0.831936241187496 VEGFA 1 GO:0030595 leukocyte chemotaxis 1/147 230/18722 0.838661063430115 0.845160121536211 VEGFA 1 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1/147 233/18722 0.842478398192268 0.848721080832965 RXFP1 1 GO:0048588 developmental cell growth 1/147 234/18722 0.84373080099749 0.849696574337876 VEGFA 1 GO:0045930 negative regulation of mitotic cell cycle 1/147 235/18722 0.844973313559874 0.850661454344525 SMAD3 1 GO:0000209 protein polyubiquitination 1/147 236/18722 0.846206013452052 0.851329359648533 CBFB 1 GO:0090068 positive regulation of cell cycle process 1/147 236/18722 0.846206013452052 0.851329359648533 PLSCR1 1 GO:0050851 antigen receptor-mediated signaling pathway 1/147 240/18722 0.851040216719911 0.85590493887332 IGKC 1 GO:0060047 heart contraction 1/147 241/18722 0.852224995864061 0.8568083907998 GJA1 1 GO:0016358 dendrite development 1/147 243/18722 0.854566548307099 0.858873839377196 TPBG 1 GO:0003015 heart process 1/147 251/18722 0.863569931138774 0.867339712570878 GJA1 1 GO:0006302 double-strand break repair 1/147 251/18722 0.863569931138774 0.867339712570878 PARP9 1 GO:0007346 regulation of mitotic cell cycle 2/147 457/18722 0.877296689822406 0.880830614051298 SMAD3/CCDC57 2 GO:0110053 regulation of actin filament organization 1/147 277/18722 0.889178127408881 0.892460328550324 SMAD3 1 GO:0098813 nuclear chromosome segregation 1/147 281/18722 0.892669240142182 0.895663769629408 GEM 1 GO:0051056 regulation of small GTPase mediated signal transduction 1/147 302/18722 0.909282143621807 0.912026455926501 TRIO 1 GO:0006310 DNA recombination 1/147 305/18722 0.911436882538018 0.913881232206239 SLC15A4 1 GO:0070372 regulation of ERK1 and ERK2 cascade 1/147 309/18722 0.914230990639664 0.916375634384462 TPBG 1 GO:0007265 Ras protein signal transduction 1/147 337/18722 0.931484666524634 0.933356997512623 RFXANK 1 GO:0031346 positive regulation of cell projection organization 1/147 353/18722 0.939746517936913 0.941320105542299 VEGFA 1 GO:0032956 regulation of actin cytoskeleton organization 1/147 357/18722 0.941652383742391 0.942913384591058 SMAD3 1 GO:0032970 regulation of actin filament-based process 1/147 396/18722 0.957365383244715 0.958326593468856 SMAD3 1 GO:0044772 mitotic cell cycle phase transition 1/147 424/18722 0.965978421321818 0.96662477690651 CCDC57 1 GO:0007015 actin filament organization 1/147 441/18722 0.970339656641303 0.970664184954561 SMAD3 1 GO:0050907 detection of chemical stimulus involved in sensory perception 1/147 477/18722 0.97782689311482 0.97782689311482 CST2 1