ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0023026	MHC class II protein complex binding	13/683	27/18367	2.88217849665079e-12	2.42391211568331e-09	HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/B2M/CD74/PKM/HLA-DOA/HLA-DMA/HLA-DMB/CD81	13
GO:0023023	MHC protein complex binding	13/683	36/18367	2.43632185348101e-10	1.02447333938877e-07	HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/B2M/CD74/PKM/HLA-DOA/HLA-DMA/HLA-DMB/CD81	13
GO:0044389	ubiquitin-like protein ligase binding	36/683	316/18367	2.49242947723782e-09	6.98711063452336e-07	ISG15/CXCR4/UBE2L6/TXNIP/JUN/NFKBIA/STAT1/CEBPB/SUMO2/TPI1/UBE2B/MAP1LC3B/GABARAPL2/TNFRSF14/DTX3L/PARP9/RALA/GPI/TRIB1/EGFR/SPOP/RBX1/RPA2/TANK/CDKN1A/CACYBP/PTK2B/SQSTM1/UBC/UBE2D1/RB1/SUMO3/CAMLG/NEDD8/PER1/SMAD7	36
GO:0042605	peptide antigen binding	11/683	36/18367	4.46057569987546e-08	9.37836040898816e-06	HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-C/HLA-F/HLA-E	11
GO:0031625	ubiquitin protein ligase binding	31/683	297/18367	2.36507441537427e-07	3.97805516665953e-05	ISG15/CXCR4/UBE2L6/TXNIP/JUN/NFKBIA/SUMO2/TPI1/UBE2B/MAP1LC3B/GABARAPL2/TNFRSF14/RALA/GPI/TRIB1/EGFR/SPOP/RBX1/RPA2/TANK/CDKN1A/CACYBP/PTK2B/SQSTM1/UBC/UBE2D1/RB1/CAMLG/NEDD8/PER1/SMAD7	31
GO:0140375	immune receptor activity	20/683	144/18367	3.88425518599764e-07	5.44443101904002e-05	FCGR2B/HLA-DQA1/CXCR4/HLA-DRB1/HLA-DQB1/FPR3/HLA-DRA/HLA-DPA1/CTSH/CD74/IL1RAP/HLA-DOA/C5AR1/LILRA5/CD44/IFNGR2/IL7R/IL27RA/EBI3/IL13RA1	20
GO:0032395	MHC class II receptor activity	6/683	10/18367	4.78157251585632e-07	5.74471783690738e-05	HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DOA	6
GO:0033218	amide binding	35/683	400/18367	2.65678548355376e-06	0.000279294573958589	FCGR2B/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-A/HLA-DRA/TREM2/HLA-DPB1/HLA-DPA1/APOE/CD74/NFKBIA/HLA-B/HLA-C/CRIP1/HLA-F/CD36/ANG/MAP1LC3B/MSR1/ANPEP/FKBP5/NUP58/ITGAM/SOAT1/KPNA3/HLA-E/EPHB2/EBI3/ACBD5/TLR2/PFDN6/PRNP/PSAP/C1QA	35
GO:0042277	peptide binding	30/683	321/18367	3.71266611033802e-06	0.000346928022088253	FCGR2B/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-A/HLA-DRA/TREM2/HLA-DPB1/HLA-DPA1/APOE/CD74/NFKBIA/HLA-B/HLA-C/CRIP1/HLA-F/CD36/ANG/MSR1/ANPEP/NUP58/ITGAM/KPNA3/HLA-E/EPHB2/EBI3/TLR2/PFDN6/PRNP/C1QA	30
GO:0003725	double-stranded RNA binding	12/683	74/18367	1.68290591254279e-05	0.00141532387244848	VIM/OAS2/EIF2AK2/OAS1/OAS3/IFIH1/MSN/DDX60/LRRFIP1/OASL/TFRC/ELAVL1	12
GO:0030246	carbohydrate binding	25/683	271/18367	2.93766442940988e-05	0.00224597798648519	HLA-DRB1/HLA-DRA/LGALS1/VCAN/SLC2A5/HK2/EGLN3/CLEC2B/P4HA1/FBP1/ALDOA/CLEC7A/CD69/LGALS3/PPP1R3B/SLC2A3/SIGLEC7/GPI/EGLN1/CLEC4A/GPCPD1/SIGLEC8/SIGLEC10/SIGLEC12/GALK1	25
GO:0003779	actin binding	34/683	440/18367	4.96539101020418e-05	0.00347991153298476	S100A4/LSP1/CXCR4/CAPG/YWHAH/MYO1G/FXYD5/TNS1/ALDOA/INF2/GSN/ANG/GMFG/ARPC4/MSN/GBP1/PARVB/FLNA/HCLS1/COTL1/EGFR/PLEC/EPB41/WIPF1/LRRK2/DST/TMSB10/ABI3/DIAPH1/CAP1/KCNMA1/IQGAP2/CFL1/MARCKS	34
GO:0048029	monosaccharide binding	11/683	71/18367	5.82119697696492e-05	0.00370953559152696	SLC2A5/HK2/EGLN3/P4HA1/FBP1/ALDOA/SLC2A3/GPI/EGLN1/CLEC4A/GALK1	11
GO:0001540	amyloid-beta binding	12/683	84/18367	6.17520788125773e-05	0.00370953559152696	FCGR2B/TREM2/APOE/CD74/CD36/MSR1/ITGAM/EPHB2/TLR2/PFDN6/PRNP/C1QA	12
GO:0031386	protein tag	5/683	13/18367	7.03244190199512e-05	0.0039428557597186	ISG15/SUMO2/UBC/SUMO3/NEDD8	5
GO:0017124	SH3 domain binding	15/683	130/18367	9.91146344281885e-05	0.00520971297213166	SH3BP5/PLSCR1/ERRFI1/OSTF1/NCF1/GRB2/ABI1/RAPGEF1/DOCK4/RUFY1/HCLS1/PTPN12/WIPF1/ABI3/GPX1	15
GO:0044548	S100 protein binding	5/683	14/18367	0.000106051235198151	0.00524641698833207	S100A6/AHNAK/CACYBP/S100A11/ANXA2	5
GO:0033691	sialic acid binding	6/683	22/18367	0.000115839442942849	0.00541227619527421	ST8SIA4/SIGLEC7/SIGLEC8/SIGLEC10/SIGLEC12/AGRN	6
GO:0005126	cytokine receptor binding	23/683	271/18367	0.000211450344426952	0.00935945998226667	VEGFA/STAT1/TNFSF13B/CXCL8/IL1RAP/ECM1/MIF/CXCL16/MYD88/PYCARD/GRB2/SMURF2/CNIH4/TNFSF12/SDCBP/CXCL2/IL27RA/CXCL3/PPBP/CCL13/CXCL12/IL13RA1/SMAD7	23
GO:0004857	enzyme inhibitor activity	10/683	70/18367	0.00025028397045842	0.0105244409577766	APOC1/TXNIP/DYNLL1/DTX3L/PARP9/ANXA1/LRRK2/ANXA2/OAZ1/ANGPTL4	10
GO:0045236	CXCR chemokine receptor binding	5/683	18/18367	0.000401008402922248	0.0160594317551243	CXCL8/CXCL2/CXCL3/PPBP/CXCL12	5
GO:0001618	virus receptor activity	10/683	76/18367	0.000493220650186759	0.0185562847427802	CXCR4/PLSCR1/ANPEP/TNFRSF14/EGFR/CD86/SELPLG/TFRC/SCARB2/CD81	10
GO:0042608	T cell receptor binding	4/683	11/18367	0.00050748460057544	0.0185562847427802	HLA-DRB1/HLA-A/HLA-DRA/HLA-E	4
GO:0140272	exogenous protein binding	10/683	77/18367	0.000548306332813328	0.019213567745667	CXCR4/PLSCR1/ANPEP/TNFRSF14/EGFR/CD86/SELPLG/TFRC/SCARB2/CD81	10
GO:0046332	SMAD binding	10/683	79/18367	0.000673806221295124	0.0217172038507877	JUN/DAB2/SKIL/SMURF2/CITED2/FOS/FLNA/ACVRL1/TOB1/SMAD7	10
GO:0019955	cytokine binding	14/683	139/18367	0.000682766163856304	0.0217172038507877	CXCR4/CD74/CD36/ZFP36/PLP2/GBP1/TNFRSF14/PDPN/IL27RA/ACVRL1/EBI3/HAX1/IL13RA1/NRP1	14
GO:0045296	cadherin binding	25/683	332/18367	0.000697222953592471	0.0217172038507877	LDHA/CAPG/STAT1/NDRG1/TAGLN2/FXYD5/ALDOA/PKM/IDH1/MAPRE1/ENO1/ABI1/CLIC1/OLA1/ANXA1/FLNA/EGFR/PLEC/KRT18/AHNAK/KIF5B/LRRFIP1/S100A11/ANXA2/CHMP5	25
GO:0035325	Toll-like receptor binding	4/683	12/18367	0.000738906027404702	0.0221935703231198	CD36/MYD88/S100A8/TLR2	4
GO:0031406	carboxylic acid binding	16/683	176/18367	0.000902812550477629	0.0254865340893393	APOC1/EGLN3/P4HA1/GLUL/SLC1A3/ST8SIA4/SIGLEC7/ALOX5AP/EGLN1/S100A8/STX3/SIGLEC8/SIGLEC10/SIGLEC12/AGRN/PSAP	16
GO:0016504	peptidase activator activity	7/683	43/18367	0.000956497021156086	0.0254865340893393	CTSH/PSME2/RPS27L/PYCARD/TANK/APH1A/FN1	7
GO:0005178	integrin binding	14/683	144/18367	0.00096839646346094	0.0254865340893393	ISG15/CD9/GPNMB/JAML/ITGAM/EGFR/DST/ICAM2/MMP14/TGFBI/IGF2/FN1/CXCL12/CD81	14
GO:0140678	molecular function inhibitor activity	13/683	128/18367	0.00096976110684763	0.0254865340893393	APOC1/TXNIP/CALM1/DYNLL1/DTX3L/PARP9/ANXA1/LRRK2/WNK1/ANXA2/OAZ1/ANGPTL4/SMAD7	13
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	4/683	13/18367	0.00103605340890903	0.0264036641482575	DUSP1/DUSP2/DUSP18/DUSP6	4
GO:0019207	kinase regulator activity	19/683	233/18367	0.0011747519652526	0.029057835375807	TREM2/CALM1/KLF4/SH3BP5/CSNK2B/GMFG/ABI1/SOCS3/CCNY/MOB3A/DAZAP2/TRIB1/WNK1/CALM3/CDKN1A/MOB1A/IGF2/CCNI/CDKN1C	19
GO:0042379	chemokine receptor binding	9/683	72/18367	0.00135429835748582	0.0320046931926714	STAT1/CXCL8/CXCL16/CNIH4/CXCL2/CXCL3/PPBP/CCL13/CXCL12	9
GO:0044325	transmembrane transporter binding	13/683	133/18367	0.00138167550505962	0.0320046931926714	YWHAH/CALM1/S100A10/TSPO/PYCARD/FLNA/KCNE1/LRRK2/CALM3/KCNAB2/DIAPH1/GRINA/PRNP	13
GO:0035259	glucocorticoid receptor binding	4/683	14/18367	0.00140805427839339	0.0320046931926714	YWHAH/CEBPB/NR4A2/NR4A1	4
GO:0002020	protease binding	13/683	135/18367	0.00158282499847261	0.0350304164135648	TIMP1/CARD16/ECM1/PYCARD/CSTB/TNFAIP3/PTEN/UBC/ANXA2/FN1/RIPK2/PRNP/PSAP	13
GO:0019887	protein kinase regulator activity	17/683	204/18367	0.00165477299402167	0.0356836945633904	CALM1/SH3BP5/CSNK2B/GMFG/ABI1/SOCS3/CCNY/MOB3A/DAZAP2/TRIB1/WNK1/CALM3/CDKN1A/MOB1A/IGF2/CCNI/CDKN1C	17
GO:0019003	GDP binding	9/683	75/18367	0.00181110560258821	0.038078495294417	RAB8A/RAP1A/GBP1/RALA/RHOA/RHOB/RRAGD/RAB42/RAB31	9
GO:0030247	polysaccharide binding	5/683	25/18367	0.00200448078552361	0.0401373414434609	HLA-DRB1/HLA-DRA/CLEC7A/PPP1R3B/GPCPD1	5
GO:0035925	mRNA 3'-UTR AU-rich region binding	5/683	25/18367	0.00200448078552361	0.0401373414434609	ZFP36L2/ZFP36/HNRNPA0/ELAVL1/CPEB2	5
GO:0008009	chemokine activity	7/683	49/18367	0.00210369256703155	0.0403463796068058	CXCL8/CXCL16/CXCL2/CXCL3/PPBP/CCL13/CXCL12	7
GO:0019209	kinase activator activity	11/683	107/18367	0.00211086884982099	0.0403463796068058	TREM2/CALM1/ABI1/CCNY/MOB3A/DAZAP2/WNK1/CALM3/CDKN1A/MOB1A/IGF2	11
GO:0008198	ferrous iron binding	5/683	26/18367	0.00240677812371905	0.0449800089343938	EGLN3/ACP5/FTH1/FTL/EGLN1	5
GO:0008047	enzyme activator activity	11/683	110/18367	0.00262867415258074	0.0480590209200087	NUPR1/APOE/APOC1/CALM1/NCF1/GMFG/DTX3L/ALOX5AP/CALM3/CTSA/PSAP	11
GO:0004709	MAP kinase kinase kinase activity	5/683	27/18367	0.0028646450611771	0.0512588616265944	EGFR/MAP3K2/LRRK2/MAP3K3/RIPK2	5
GO:0061650	ubiquitin-like protein conjugating enzyme activity	6/683	39/18367	0.00296123891503217	0.0518833734904595	UBE2L6/UBE2B/UBE2F/UBE2D2/UBE2D1/UBE2Q2	6
GO:0042287	MHC protein binding	6/683	40/18367	0.00337626797257727	0.0579477829579078	CD74/CLEC7A/PILRA/LAG3/HLA-E/CD81	6
GO:0033549	MAP kinase phosphatase activity	4/683	18/18367	0.0038239937276801	0.0630584063721365	DUSP1/DUSP2/DUSP18/DUSP6	4
GO:0098641	cadherin binding involved in cell-cell adhesion	4/683	18/18367	0.0038239937276801	0.0630584063721365	ANXA1/KRT18/S100A11/ANXA2	4
GO:0003924	GTPase activity	23/683	337/18367	0.00392585018736728	0.063493077068767	RGS1/MX2/MX1/GNAQ/RAB8A/GNG5/RAP1A/RAB20/RAC1/GBP1/RALA/RHOA/RGS2/RHOB/RHOC/LRRK2/GBP4/RND3/RRAGD/RAB13/RAB42/GBP3/RAB31	23
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	21/683	299/18367	0.00411959300763395	0.0653693909324558	JUND/IFI27/YWHAH/JUN/NFKBIA/STAT1/KLF4/FBP1/CEBPB/NR4A2/BHLHE40/CITED2/DTX3L/FOS/PARP9/HCLS1/SPI1/OASL/RB1/MDFIC/NR4A1	21
GO:0030295	protein kinase activator activity	10/683	101/18367	0.00434160657270794	0.0676165023638403	CALM1/ABI1/CCNY/MOB3A/DAZAP2/WNK1/CALM3/CDKN1A/MOB1A/IGF2	10
GO:0050840	extracellular matrix binding	7/683	56/18367	0.00454250542742858	0.0692851852401579	LGALS1/VEGFA/ECM1/LGALS3/TGFBI/ANXA2/AGRN	7
GO:0070566	adenylyltransferase activity	5/683	30/18367	0.00461352006355391	0.0692851852401579	OAS2/OAS1/OAS3/PAPSS1/PAPSS2	5
GO:0008022	protein C-terminus binding	15/683	189/18367	0.00477767894533208	0.0704917191758645	DAB2/ECM1/MAPRE1/TNFAIP3/PPP2CB/EPB41/DST/SDCBP/KPNA3/NCL/PTK2B/FOXN3/FN1/PHB/VTA1	15
GO:0008330	protein tyrosine/threonine phosphatase activity	3/683	10/18367	0.0050507698528513	0.0719948719703042	DUSP1/DUSP2/DUSP6	3
GO:0098505	G-rich strand telomeric DNA binding	3/683	10/18367	0.0050507698528513	0.0719948719703042	TERF2IP/RPA2/HNRNPA1	3
GO:0048306	calcium-dependent protein binding	9/683	88/18367	0.00538664720444229	0.0755028383155995	S100A4/CALM1/S100A6/S100A10/ANXA1/CALM3/S100A8/S100A11/ANXA2	9
GO:0032934	sterol binding	7/683	60/18367	0.00666110424666182	0.0897813891670322	GPR183/TSPO/OSBPL1A/SOAT1/INSIG2/SCARB2/CD81	7
GO:0008199	ferric iron binding	3/683	11/18367	0.00675450182245475	0.0897813891670322	ACP5/FTH1/FTL	3
GO:0047134	protein-disulfide reductase (NAD(P)) activity	3/683	11/18367	0.00675450182245475	0.0897813891670322	PGK1/GLRX/TXN	3
GO:0140297	DNA-binding transcription factor binding	25/683	394/18367	0.00683235304005952	0.0897813891670322	JUND/IFI27/YWHAH/JUN/NFKBIA/STAT1/KLF4/FBP1/CEBPB/NR4A2/BHLHE40/PTMA/CITED2/DTX3L/FOS/PARP9/HCLS1/CGGBP1/SPI1/OASL/RB1/EIF4E/MDFIC/NR4A1/NLRP3	25
GO:0005125	cytokine activity	17/683	235/18367	0.0069964179507275	0.0905228845624896	VEGFA/TNFSF13B/TIMP1/CXCL8/MIF/CXCL16/NAMPT/GPI/TNFSF12/CXCL2/GRN/CXCL3/PPBP/CCL13/EBI3/CXCL12/CMTM7	17
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	6/683	47/18367	0.00758905427462678	0.095259621566584	DUSP1/PTP4A2/PTEN/DUSP2/DUSP18/DUSP6	6
GO:0035254	glutamate receptor binding	6/683	47/18367	0.00758905427462678	0.095259621566584	CALM1/PTEN/CALM3/MYL12A/SQSTM1/PRNP	6
GO:0038024	cargo receptor activity	8/683	77/18367	0.00772865664382031	0.0955852976096011	DAB2/LGALS3BP/CD36/CXCL16/MSR1/ITGAM/TFRC/SCARB2	8
GO:0031543	peptidyl-proline dioxygenase activity	3/683	12/18367	0.00875970042080475	0.102318167415233	EGLN3/P4HA1/EGLN1	3
GO:0035256	G protein-coupled glutamate receptor binding	3/683	12/18367	0.00875970042080475	0.102318167415233	CALM1/CALM3/PRNP	3
GO:0043047	single-stranded telomeric DNA binding	3/683	12/18367	0.00875970042080475	0.102318167415233	TERF2IP/RPA2/HNRNPA1	3
GO:0097677	STAT family protein binding	3/683	12/18367	0.00875970042080475	0.102318167415233	DTX3L/PARP9/SPI1	3
GO:0016763	pentosyltransferase activity	6/683	49/18367	0.00928679756635744	0.106988996620638	TYMP/UPP1/NAMPT/PARP9/PARP12/TIPARP	6
GO:0004896	cytokine receptor activity	9/683	97/18367	0.0100558350966254	0.111056058867598	CXCR4/CD74/IL1RAP/CD44/IFNGR2/IL7R/IL27RA/EBI3/IL13RA1	9
GO:0043394	proteoglycan binding	5/683	36/18367	0.0101680339272355	0.111056058867598	GPNMB/APOE/SDCBP/FN1/AGRN	5
GO:0061631	ubiquitin conjugating enzyme activity	5/683	36/18367	0.0101680339272355	0.111056058867598	UBE2L6/UBE2B/UBE2D2/UBE2D1/UBE2Q2	5
GO:0097718	disordered domain specific binding	5/683	36/18367	0.0101680339272355	0.111056058867598	CALM1/GAPDH/CALM3/RB1/FN1	5
GO:0140677	molecular function activator activity	12/683	150/18367	0.0103088652137782	0.111150713394711	NUPR1/APOE/APOC1/CALM1/NCF1/GMFG/DTX3L/ALOX5AP/DNAJC15/CALM3/CTSA/PSAP	12
GO:0004859	phospholipase inhibitor activity	3/683	13/18367	0.0110767945243735	0.113604685304855	APOC1/ANXA1/ANXA2	3
GO:0008179	adenylate cyclase binding	3/683	13/18367	0.0110767945243735	0.113604685304855	CALM1/CALM3/CAP1	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/683	13/18367	0.0110767945243735	0.113604685304855	PGK1/GLRX/TXN	3
GO:0072542	protein phosphatase activator activity	3/683	13/18367	0.0110767945243735	0.113604685304855	CALM1/PPP1R15A/CALM3	3
GO:0015035	protein-disulfide reductase activity	5/683	37/18367	0.0114057323071613	0.115568926148466	PGK1/ERO1A/GLRX/SCO2/TXN	5
GO:0003823	antigen binding	13/683	171/18367	0.0116434043336784	0.116572655293137	HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-C/HLA-F/LAG3/IL7R/HLA-E	13
GO:0061134	peptidase regulator activity	16/683	230/18367	0.0123724395417357	0.122414372407056	CTSH/TIMP1/CARD16/PSME2/SERPING1/RPS27L/BST2/GAPDH/PYCARD/CSTB/TANK/APH1A/ANXA2/FN1/SERPINB1/PRNP	16
GO:0035035	histone acetyltransferase binding	4/683	25/18367	0.0128718412821079	0.125874633933171	STAT1/CEBPB/CITED2/EGR1	4
GO:0004298	threonine-type endopeptidase activity	3/683	14/18367	0.0137137236823681	0.129586984459231	PSMB9/PSMB8/PSMB10	3
GO:0036041	long-chain fatty acid binding	3/683	14/18367	0.0137137236823681	0.129586984459231	ALOX5AP/S100A8/STX3	3
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	3/683	14/18367	0.0137137236823681	0.129586984459231	HSD17B4/HSD17B11/HSD17B1	3
GO:0005525	GTP binding	23/683	377/18367	0.0142247093280734	0.132922006054553	MX2/IFI44L/MX1/GNAQ/RAB8A/RAP1A/RAB20/OLA1/GIMAP4/RAC1/GBP1/RALA/RHOA/RHOB/RHOC/LRRK2/GBP4/RND3/RRAGD/RAB13/RAB42/GBP3/RAB31	23
GO:0016209	antioxidant activity	8/683	86/18367	0.0146036560930719	0.133392766372574	APOE/SOD2/HBG1/GLRX/CLIC2/ALOX5AP/TXN/GPX1	8
GO:0001664	G protein-coupled receptor binding	19/683	295/18367	0.0146758943880954	0.133392766372574	STAT1/CALM1/CXCL8/ADM/GNAQ/CXCL16/RALA/FLNA/CNIH4/ARRDC3/SDCBP/CXCL2/CALM3/CXCL3/PPBP/CCL13/PHB/CXCL12/PRNP	19
GO:0038187	pattern recognition receptor activity	4/683	26/18367	0.0147745800381786	0.133392766372574	CLEC7A/CD36/PTAFR/TLR2	4
GO:0019902	phosphatase binding	14/683	196/18367	0.0150430274802662	0.133392766372574	STAT1/PPP1R15A/TERF2IP/IRS2/SHOC2/LGALS3/PPP1R3B/GRB2/EIF4EBP1/EGFR/RPA2/WNK1/SIGLEC10/CHCHD3	14
GO:0004860	protein kinase inhibitor activity	7/683	70/18367	0.0150681484011825	0.133392766372574	SH3BP5/GMFG/SOCS3/TRIB1/WNK1/CDKN1A/CDKN1C	7
GO:0005545	1-phosphatidylinositol binding	3/683	15/18367	0.0166761561917186	0.143108646502402	SNX10/EPB41/WDFY1	3
GO:0050998	nitric-oxide synthase binding	3/683	15/18367	0.0166761561917186	0.143108646502402	CD74/CALM1/CALM3	3
GO:0098847	sequence-specific single stranded DNA binding	3/683	15/18367	0.0166761561917186	0.143108646502402	TERF2IP/RPA2/HNRNPA1	3
GO:0051087	chaperone binding	9/683	107/18367	0.0182558138946787	0.153284749436884	HLA-B/PDPN/PTGES3/GRN/FN1/SCARB2/PFDN6/TIMM10/PRNP	9
GO:0106306	protein serine phosphatase activity	7/683	73/18367	0.0186343001162911	0.153284749436884	DUSP1/PPP1CB/PTEN/PPP2CB/DUSP2/DUSP18/DUSP6	7
GO:0106307	protein threonine phosphatase activity	7/683	73/18367	0.0186343001162911	0.153284749436884	DUSP1/PPP1CB/PTEN/PPP2CB/DUSP2/DUSP18/DUSP6	7
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	6/683	57/18367	0.0188069863893744	0.153284749436884	PGK1/ERO1A/GLRX/SCO2/TXN/IFI30	6
GO:0043236	laminin binding	4/683	28/18367	0.0190898068108364	0.153284749436884	LGALS1/ECM1/LGALS3/AGRN	4
GO:0001046	core promoter sequence-specific DNA binding	5/683	42/18367	0.0191378105717869	0.153284749436884	STAT1/CEBPB/KLF10/DRAP1/FOS	5
GO:0015036	disulfide oxidoreductase activity	5/683	42/18367	0.0191378105717869	0.153284749436884	PGK1/ERO1A/GLRX/SCO2/TXN	5
GO:0019210	kinase inhibitor activity	7/683	74/18367	0.0199441933783323	0.154062656377205	SH3BP5/GMFG/SOCS3/TRIB1/WNK1/CDKN1A/CDKN1C	7
GO:0005521	lamin binding	3/683	16/18367	0.0199676926814689	0.154062656377205	IFI27/BNIP3L/PRNP	3
GO:0050700	CARD domain binding	3/683	16/18367	0.0199676926814689	0.154062656377205	CARD16/CARD19/RIPK2	3
GO:1990404	protein ADP-ribosylase activity	3/683	16/18367	0.0199676926814689	0.154062656377205	PARP9/PARP12/TIPARP	3
GO:0047485	protein N-terminus binding	9/683	110/18367	0.0214631936884388	0.164095871745246	CALM1/GLRX/ALOX5AP/RPA2/EPB41/SDCBP/CALM3/MORF4L1/HAX1	9
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	3/683	17/18367	0.023590056044174	0.172515105505655	CTSH/RPS27L/PYCARD	3
GO:0030169	low-density lipoprotein particle binding	3/683	17/18367	0.023590056044174	0.172515105505655	TREM2/CD36/MSR1	3
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3/683	17/18367	0.023590056044174	0.172515105505655	ATP6V1F/ATP6V1G1/ATP6V1B2	3
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	3/683	17/18367	0.023590056044174	0.172515105505655	ATP6V1F/ATP6V1G1/ATP6V1B2	3
GO:0046961	proton-transporting ATPase activity, rotational mechanism	3/683	17/18367	0.023590056044174	0.172515105505655	ATP6V1F/ATP6V1G1/ATP6V1B2	3
GO:0051020	GTPase binding	18/683	291/18367	0.0246942699449369	0.178342849829901	NDRG1/YBX3/ERRFI1/RAB8A/INF2/RAP1A/BNIP3/RIN3/ENO1/RAC1/DOCK4/FLNA/YBX1/LRRK2/RRAGD/DIAPH1/ANXA2/IQGAP2	18
GO:0019001	guanyl nucleotide binding	23/683	398/18367	0.0250231346967042	0.178342849829901	MX2/IFI44L/MX1/GNAQ/RAB8A/RAP1A/RAB20/OLA1/GIMAP4/RAC1/GBP1/RALA/RHOA/RHOB/RHOC/LRRK2/GBP4/RND3/RRAGD/RAB13/RAB42/GBP3/RAB31	23
GO:0032561	guanyl ribonucleotide binding	23/683	398/18367	0.0250231346967042	0.178342849829901	MX2/IFI44L/MX1/GNAQ/RAB8A/RAP1A/RAB20/OLA1/GIMAP4/RAC1/GBP1/RALA/RHOA/RHOB/RHOC/LRRK2/GBP4/RND3/RRAGD/RAB13/RAB42/GBP3/RAB31	23
GO:0005539	glycosaminoglycan binding	15/683	230/18367	0.025403390765018	0.179531526330926	TREM2/VEGFA/GPNMB/APOE/VCAN/SULF2/CD44/ANG/LYVE1/FN1/TLR2/AGRN/NLRP3/PRNP/NRP1	15
GO:0071813	lipoprotein particle binding	4/683	31/18367	0.02689074439834	0.185311110518277	TREM2/APOE/CD36/MSR1	4
GO:0071814	protein-lipid complex binding	4/683	31/18367	0.02689074439834	0.185311110518277	TREM2/APOE/CD36/MSR1	4
GO:0004303	estradiol 17-beta-dehydrogenase activity	3/683	18/18367	0.0275432685074727	0.185311110518277	HSD17B4/HSD17B11/HSD17B1	3
GO:0042834	peptidoglycan binding	3/683	18/18367	0.0275432685074727	0.185311110518277	TREM2/TLR2/NLRP3	3
GO:0048038	quinone binding	3/683	18/18367	0.0275432685074727	0.185311110518277	SDHD/SDHB/VKORC1	3
GO:0055102	lipase inhibitor activity	3/683	18/18367	0.0275432685074727	0.185311110518277	APOC1/ANXA1/ANXA2	3
GO:0043177	organic acid binding	10/683	135/18367	0.0293150721177933	0.194642891722802	EGLN3/P4HA1/GLUL/SLC1A3/HBG1/ALOX5AP/DDAH2/EGLN1/S100A8/STX3	10
GO:0004722	protein serine/threonine phosphatase activity	8/683	98/18367	0.0295546047211039	0.194642891722802	DUSP1/PPP1CB/PTEN/PPP2CB/LRRK2/DUSP2/DUSP18/DUSP6	8
GO:0005044	scavenger receptor activity	5/683	47/18367	0.0296967930198819	0.194642891722802	LGALS3BP/CD36/CXCL16/MSR1/SCARB2	5
GO:0071889	14-3-3 protein binding	4/683	32/18367	0.0298560440335808	0.194642891722802	DDIT4/HLA-F/ZFP36/IRS2	4
GO:0005496	steroid binding	8/683	100/18367	0.0328018521747847	0.211899418048762	GPR183/TSPO/OSBPL1A/SOAT1/INSIG2/SCARB2/CD81/HSD17B1	8
GO:0019956	chemokine binding	4/683	33/18367	0.0330069248090224	0.211899418048762	CXCR4/ZFP36/PLP2/PDPN	4
GO:0043539	protein serine/threonine kinase activator activity	5/683	49/18367	0.0347729510846816	0.218869076804896	CALM1/CCNY/DAZAP2/CALM3/IGF2	5
GO:0035198	miRNA binding	4/683	34/18367	0.0363445314469336	0.218869076804896	HIF1A-AS2/YBX1/HNRNPA1/ELAVL1	4
GO:0043548	phosphatidylinositol 3-kinase binding	4/683	34/18367	0.0363445314469336	0.218869076804896	CALM1/GSN/IRS2/CALM3	4
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/683	20/18367	0.0364348046999827	0.218869076804896	STAT1/CEBPB/FOS	3
GO:0001091	RNA polymerase II general transcription initiation factor binding	3/683	20/18367	0.0364348046999827	0.218869076804896	AHR/DRAP1/EDF1	3
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	3/683	20/18367	0.0364348046999827	0.218869076804896	ATP6V1F/ATP6V1G1/ATP6V1B2	3
GO:0016505	peptidase activator activity involved in apoptotic process	3/683	20/18367	0.0364348046999827	0.218869076804896	CTSH/RPS27L/PYCARD	3
GO:0019211	phosphatase activator activity	3/683	20/18367	0.0364348046999827	0.218869076804896	CALM1/PPP1R15A/CALM3	3
GO:0031418	L-ascorbic acid binding	3/683	20/18367	0.0364348046999827	0.218869076804896	EGLN3/P4HA1/EGLN1	3
GO:0015485	cholesterol binding	5/683	50/18367	0.037499933336888	0.223669815151225	TSPO/OSBPL1A/SOAT1/SCARB2/CD81	5
GO:0070851	growth factor receptor binding	10/683	141/18367	0.0378566145913334	0.223685240675052	VEGFA/PLSCR1/IL1RAP/ECM1/MYD88/PYCARD/GRB2/PTEN/SDCBP/IL27RA	10
GO:0097110	scaffold protein binding	6/683	67/18367	0.0380344701742359	0.223685240675052	VIM/TREM2/DYNLL1/TREM1/KRT18/PSAP	6
GO:0016860	intramolecular oxidoreductase activity	5/683	51/18367	0.0403543285142515	0.235680488058927	ERO1A/TPI1/MIF/GPI/PTGES3	5
GO:0001848	complement binding	3/683	21/18367	0.0413660979068167	0.239923367859537	C5AR1/ITGAM/PHB	3
GO:0003727	single-stranded RNA binding	7/683	87/18367	0.0431316360211847	0.247522630672619	IFIH1/IFIT5/SSB/CNBP/ANXA1/DDX60/HNRNPA1	7
GO:0005543	phospholipid binding	25/683	466/18367	0.0432649544695303	0.247522630672619	TREM2/CAPG/APOE/CD300A/APOC1/MYO1G/SNX10/ZCCHC2/NCF1/GSN/FCHO2/ANXA1/WDR45B/PTAFR/EPB41/AIDA/OSBPL1A/SDCBP/PHLDA2/WIPI2/ANXA2/SCARB2/WDFY1/IQGAP2/PSAP	25
GO:0042162	telomeric DNA binding	4/683	36/18367	0.0435822445346292	0.247653159821778	TERF2IP/RPA2/NCL/HNRNPA1	4
GO:0019208	phosphatase regulator activity	8/683	107/18367	0.0460544559401687	0.253740670601002	EIF2AK2/CALM1/PPP1R15A/SHOC2/LGALS3/PPP1R3B/CALM3/ANP32E	8
GO:1902936	phosphatidylinositol bisphosphate binding	8/683	107/18367	0.0460544559401687	0.253740670601002	CAPG/MYO1G/GSN/FCHO2/WDR45B/SDCBP/WIPI2/ANXA2	8
GO:0004602	glutathione peroxidase activity	3/683	22/18367	0.0466144547596815	0.253740670601002	CLIC2/ALOX5AP/GPX1	3
GO:0005355	glucose transmembrane transporter activity	3/683	22/18367	0.0466144547596815	0.253740670601002	SLC2A5/SLC2A3/PPBP	3
GO:0005540	hyaluronic acid binding	3/683	22/18367	0.0466144547596815	0.253740670601002	VCAN/CD44/LYVE1	3
GO:0015149	hexose transmembrane transporter activity	3/683	22/18367	0.0466144547596815	0.253740670601002	SLC2A5/SLC2A3/PPBP	3
GO:0035091	phosphatidylinositol binding	16/683	271/18367	0.046876950230704	0.253740670601002	CAPG/MYO1G/SNX10/ZCCHC2/NCF1/GSN/FCHO2/WDR45B/EPB41/AIDA/SDCBP/PHLDA2/WIPI2/ANXA2/WDFY1/IQGAP2	16
GO:0003714	transcription corepressor activity	12/683	187/18367	0.0470672349747399	0.253740670601002	SAP30/TRIM22/IRF2BP2/DRAP1/CITED2/PARP9/COPS2/CIR1/TLE3/RB1/TOB1/PHB	12
GO:0042056	chemoattractant activity	4/683	37/18367	0.0474824278349283	0.254348546555253	VEGFA/GPNMB/MIF/LGALS3	4
GO:0019888	protein phosphatase regulator activity	7/683	89/18367	0.047794897530192	0.254401954575263	EIF2AK2/CALM1/PPP1R15A/SHOC2/LGALS3/PPP1R3B/CALM3	7
GO:0015459	potassium channel regulator activity	5/683	54/18367	0.049689626756889	0.261409869740605	SGK1/FLNA/KCNE1/WNK1/KCNAB2	5
GO:0001094	TFIID-class transcription factor complex binding	2/683	10/18367	0.0509764787603557	0.261409869740605	AHR/EDF1	2
GO:0005384	manganese ion transmembrane transporter activity	2/683	10/18367	0.0509764787603557	0.261409869740605	SLC11A1/ATP2C1	2
GO:0016595	glutamate binding	2/683	10/18367	0.0509764787603557	0.261409869740605	GLUL/SLC1A3	2
GO:0050786	RAGE receptor binding	2/683	10/18367	0.0509764787603557	0.261409869740605	S100A4/S100A8	2
GO:0070008	serine-type exopeptidase activity	2/683	10/18367	0.0509764787603557	0.261409869740605	CTSA/CPD	2
GO:0003950	NAD+ ADP-ribosyltransferase activity	3/683	23/18367	0.0521736505180049	0.262742755003845	PARP9/PARP12/TIPARP	3
GO:0019865	immunoglobulin binding	3/683	23/18367	0.0521736505180049	0.262742755003845	FCGR2B/LGALS3/FCGR3A	3
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	3/683	23/18367	0.0521736505180049	0.262742755003845	TNFAIP3/TAB2/SQSTM1	3
GO:0019903	protein phosphatase binding	10/683	150/18367	0.0536648215430651	0.268643541176891	STAT1/PPP1R15A/IRS2/SHOC2/LGALS3/PPP1R3B/GRB2/EIF4EBP1/EGFR/RPA2	10
GO:0005506	iron ion binding	10/683	151/18367	0.0556546716285828	0.276256401989435	ALOX5/EGLN3/SCD/P4HA1/ACP5/FTH1/FTL/EGLN1/CYP1B1/FBXL5	10
GO:0005504	fatty acid binding	4/683	39/18367	0.0558425545044041	0.276256401989435	APOC1/ALOX5AP/S100A8/STX3	4
GO:0017022	myosin binding	6/683	74/18367	0.0570380510159648	0.280520473125301	CXCR4/RAB8A/GSN/PYCARD/RALA/RHOA	6
GO:0015145	monosaccharide transmembrane transporter activity	3/683	24/18367	0.0580365915059121	0.282131638476717	SLC2A5/SLC2A3/PPBP	3
GO:0070003	threonine-type peptidase activity	3/683	24/18367	0.0580365915059121	0.282131638476717	PSMB9/PSMB8/PSMB10	3
GO:0003925	G protein activity	4/683	40/18367	0.060300177132926	0.284087859843631	RAP1A/RAC1/RALA/RHOA	4
GO:0004721	phosphoprotein phosphatase activity	11/683	174/18367	0.0606436603378817	0.284087859843631	DUSP1/PPP1CB/PPP1R3B/PTP4A2/PTEN/PPP2CB/PTPN12/LRRK2/DUSP2/DUSP18/DUSP6	11
GO:0002162	dystroglycan binding	2/683	11/18367	0.060803584746556	0.284087859843631	PLEC/AGRN	2
GO:0005536	glucose binding	2/683	11/18367	0.060803584746556	0.284087859843631	HK2/SLC2A3	2
GO:0019864	IgG binding	2/683	11/18367	0.060803584746556	0.284087859843631	FCGR2B/FCGR3A	2
GO:0051400	BH domain binding	2/683	11/18367	0.060803584746556	0.284087859843631	MCL1/BCL2A1	2
GO:0097493	structural molecule activity conferring elasticity	2/683	11/18367	0.060803584746556	0.284087859843631	FBN2/AHNAK	2
GO:0016829	lyase activity	12/683	196/18367	0.0627467799222866	0.29154719289858	RSAD2/ALDOA/RNASET2/HSD17B4/TPI1/ENO1/ALOX5AP/ENO2/HACD4/RNASE1/CYP1B1/UROD	12
GO:0048018	receptor ligand activity	25/683	487/18367	0.0655210691962042	0.302764940626416	VEGFA/GPNMB/TNFSF13B/TIMP1/TYMP/CXCL8/ADM/MIF/CXCL16/HAMP/GMFG/NAMPT/LGALS3/CGA/GPI/TNFSF12/CXCL2/GRN/CXCL3/IGF2/PPBP/CCL13/EBI3/CXCL12/CMTM7	25
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	9/683	136/18367	0.0674139072625099	0.309809267802026	LDHA/HSD17B4/HSD17B11/IDH1/DHRS3/KCNAB2/VKORC1/ALDH3A2/HSD17B1	9
GO:0015631	tubulin binding	20/683	375/18367	0.0684109646517714	0.312682724305107	ATF5/MX2/MX1/NDRG1/ALDOA/DPYSL2/MAP1LC3B/GAPDH/GABARAPL2/MAPRE1/RGS2/BLOC1S2/LRRK2/DST/S100A8/KIF5B/CACYBP/RMDN1/SETD2/PRNP	20
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	2/683	12/18367	0.0712123616117062	0.316876169922989	CDKN1A/CDKN1C	2
GO:0004875	complement receptor activity	2/683	12/18367	0.0712123616117062	0.316876169922989	FPR3/C5AR1	2
GO:0005095	GTPase inhibitor activity	2/683	12/18367	0.0712123616117062	0.316876169922989	IQGAP2/CPEB2	2
GO:0008429	phosphatidylethanolamine binding	2/683	12/18367	0.0712123616117062	0.316876169922989	TREM2/CD300A	2
GO:0089720	caspase binding	2/683	12/18367	0.0712123616117062	0.316876169922989	CARD16/RIPK2	2
GO:0001786	phosphatidylserine binding	5/683	60/18367	0.0718559970723539	0.318057334409735	TREM2/CD300A/FCHO2/ANXA2/SCARB2	5
GO:0016835	carbon-oxygen lyase activity	6/683	79/18367	0.0735556452289138	0.323875903861343	HSD17B4/TPI1/ENO1/ENO2/HACD4/CYP1B1	6
GO:0030546	signaling receptor activator activity	25/683	495/18367	0.0758028562001272	0.329465612783607	VEGFA/GPNMB/TNFSF13B/TIMP1/TYMP/CXCL8/ADM/MIF/CXCL16/HAMP/GMFG/NAMPT/LGALS3/CGA/GPI/TNFSF12/CXCL2/GRN/CXCL3/IGF2/PPBP/CCL13/EBI3/CXCL12/CMTM7	25
GO:0005507	copper ion binding	5/683	61/18367	0.0760003910582874	0.329465612783607	HAMP/SCO2/ANG/COA6/PRNP	5
GO:0043621	protein self-association	5/683	61/18367	0.0760003910582874	0.329465612783607	ADAM8/RSAD2/MYD88/TNFAIP3/PLEC	5
GO:0008139	nuclear localization sequence binding	3/683	27/18367	0.0773660858225231	0.331963664167051	NFKBIA/NUP58/KPNA3	3
GO:0051119	sugar transmembrane transporter activity	3/683	27/18367	0.0773660858225231	0.331963664167051	SLC2A5/SLC2A3/PPBP	3
GO:0008375	acetylglucosaminyltransferase activity	4/683	44/18367	0.0799375450381227	0.341256220188128	B3GNT7/GCNT1/HEXB/B3GNT5	4
GO:0008035	high-density lipoprotein particle binding	2/683	13/18367	0.0821461010821303	0.343705825920754	TREM2/CD36	2
GO:0031432	titin binding	2/683	13/18367	0.0821461010821303	0.343705825920754	CALM1/CALM3	2
GO:0061133	endopeptidase activator activity	2/683	13/18367	0.0821461010821303	0.343705825920754	PSME2/APH1A	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/683	13/18367	0.0821461010821303	0.343705825920754	HSD17B11/HSD17B1	2
GO:0003953	NAD+ nucleosidase activity	3/683	28/18367	0.0843592393039256	0.348954275206641	IL1RAP/MYD88/TLR2	3
GO:0046875	ephrin receptor binding	3/683	28/18367	0.0843592393039256	0.348954275206641	GRB2/SDCBP/SIPA1L1	3
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	6/683	82/18367	0.0846452700857964	0.348954275206641	CAPG/MYO1G/GSN/FCHO2/SDCBP/ANXA2	6
GO:0004725	protein tyrosine phosphatase activity	7/683	102/18367	0.0857566834988799	0.351811564988088	DUSP1/PTP4A2/PTEN/PTPN12/DUSP2/DUSP18/DUSP6	7
GO:0016836	hydro-lyase activity	5/683	64/18367	0.0891883408020561	0.362526080517377	HSD17B4/ENO1/ENO2/HACD4/CYP1B1	5
GO:0005200	structural constituent of cytoskeleton	7/683	103/18367	0.0892305572735994	0.362526080517377	VIM/HLA-DRB1/ARPC4/MSN/PLEC/EPB41/AGRN	7
GO:0061980	regulatory RNA binding	4/683	46/18367	0.0908042926193854	0.367146202369726	HIF1A-AS2/YBX1/HNRNPA1/ELAVL1	4
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	2/683	14/18367	0.093551497315424	0.374651472582245	B3GNT7/B3GNT5	2
GO:0043023	ribosomal large subunit binding	2/683	14/18367	0.093551497315424	0.374651472582245	OLA1/CPEB2	2
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/683	47/18367	0.096488711186781	0.384582967336886	ATP6V1F/ATP6V1G1/ATP6V1B2/ATP2C1	4
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3/683	30/18367	0.0991112640913995	0.393172514626731	HSD17B4/HSD17B11/HSD17B1	3
GO:0030695	GTPase regulator activity	24/683	488/18367	0.100520442278924	0.395035943722312	RGS1/JUN/SH3BP5/ERRFI1/GNAQ/TAGAP/ARHGAP30/RAP1A/RIN3/RAPGEF1/RALGDS/DOCK4/RGS2/LAMTOR5/LRRK2/SOS2/DOCK8/ARL2BP/RIN2/IQGAP2/CPEB2/ARHGEF40/SIPA1L1/NRP1	24
GO:0060589	nucleoside-triphosphatase regulator activity	24/683	488/18367	0.100520442278924	0.395035943722312	RGS1/JUN/SH3BP5/ERRFI1/GNAQ/TAGAP/ARHGAP30/RAP1A/RIN3/RAPGEF1/RALGDS/DOCK4/RGS2/LAMTOR5/LRRK2/SOS2/DOCK8/ARL2BP/RIN2/IQGAP2/CPEB2/ARHGEF40/SIPA1L1/NRP1	24
GO:0031267	small GTPase binding	14/683	259/18367	0.104473729409853	0.397413882000553	NDRG1/YBX3/ERRFI1/RAB8A/INF2/RAP1A/RIN3/RAC1/DOCK4/FLNA/LRRK2/DIAPH1/ANXA2/IQGAP2	14
GO:0001846	opsonin binding	2/683	15/18367	0.105378472872917	0.397413882000553	ITGAM/PHB	2
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/683	15/18367	0.105378472872917	0.397413882000553	ALDH2/ALDH3A2	2
GO:0005041	low-density lipoprotein particle receptor activity	2/683	15/18367	0.105378472872917	0.397413882000553	CD36/CXCL16	2
GO:0005161	platelet-derived growth factor receptor binding	2/683	15/18367	0.105378472872917	0.397413882000553	VEGFA/PTEN	2
GO:0010851	cyclase regulator activity	2/683	15/18367	0.105378472872917	0.397413882000553	CALM1/CALM3	2
GO:0048185	activin binding	2/683	15/18367	0.105378472872917	0.397413882000553	ACVRL1/SMAD7	2
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	2/683	15/18367	0.105378472872917	0.397413882000553	NCF1/KMO	2
GO:0071933	Arp2/3 complex binding	2/683	15/18367	0.105378472872917	0.397413882000553	GMFG/IQGAP2	2
GO:0005164	tumor necrosis factor receptor binding	3/683	31/18367	0.106849176915656	0.397611317637462	STAT1/TNFSF13B/TNFSF12	3
GO:0008157	protein phosphatase 1 binding	3/683	31/18367	0.106849176915656	0.397611317637462	PPP1R15A/SHOC2/PPP1R3B	3
GO:0140318	protein transporter activity	3/683	31/18367	0.106849176915656	0.397611317637462	MCL1/SEC61G/TIMM8B	3
GO:0032813	tumor necrosis factor receptor superfamily binding	4/683	49/18367	0.108341229281906	0.399627078184575	STAT1/TNFSF13B/MYD88/TNFSF12	4
GO:0098632	cell-cell adhesion mediator activity	4/683	49/18367	0.108341229281906	0.399627078184575	ANXA1/KRT18/S100A11/ANXA2	4
GO:0061135	endopeptidase regulator activity	11/683	194/18367	0.109161862662957	0.400895748906317	TIMP1/CARD16/PSME2/SERPING1/BST2/GAPDH/CSTB/APH1A/ANXA2/SERPINB1/PRNP	11
GO:0051015	actin filament binding	12/683	217/18367	0.111578455252718	0.40693329567541	CAPG/MYO1G/GSN/ARPC4/FLNA/HCLS1/COTL1/EGFR/ABI3/IQGAP2/CFL1/MARCKS	12
GO:1901981	phosphatidylinositol phosphate binding	10/683	173/18367	0.111854491737116	0.40693329567541	CAPG/MYO1G/GSN/FCHO2/WDR45B/SDCBP/PHLDA2/WIPI2/ANXA2/IQGAP2	10
GO:0043178	alcohol binding	6/683	89/18367	0.113869977231021	0.40693329567541	TSPO/RBP1/OSBPL1A/SOAT1/SCARB2/CD81	6
GO:0051117	ATPase binding	6/683	89/18367	0.113869977231021	0.40693329567541	SNX10/GABARAPL2/RAC1/ATP6V1G1/RALA/EGFR	6
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/683	50/18367	0.114501341972777	0.40693329567541	CCNY/CDKN1A/CCNI/CDKN1C	4
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/683	16/18367	0.117580012900267	0.40693329567541	ALDH2/ALDH3A2	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	2/683	16/18367	0.117580012900267	0.40693329567541	CAPN2/CAPNS1	2
GO:0005159	insulin-like growth factor receptor binding	2/683	16/18367	0.117580012900267	0.40693329567541	YWHAH/IGF2	2
GO:0005283	amino acid:sodium symporter activity	2/683	16/18367	0.117580012900267	0.40693329567541	SLC1A3/SLC38A2	2
GO:0005523	tropomyosin binding	2/683	16/18367	0.117580012900267	0.40693329567541	S100A6/PYCARD	2
GO:0008191	metalloendopeptidase inhibitor activity	2/683	16/18367	0.117580012900267	0.40693329567541	TIMP1/BST2	2
GO:0016307	phosphatidylinositol phosphate kinase activity	2/683	16/18367	0.117580012900267	0.40693329567541	PIP4K2A/PIK3CB	2
GO:0050135	NAD(P)+ nucleosidase activity	2/683	16/18367	0.117580012900267	0.40693329567541	IL1RAP/TLR2	2
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	2/683	16/18367	0.117580012900267	0.40693329567541	IL1RAP/TLR2	2
GO:0004601	peroxidase activity	4/683	51/18367	0.120811726096907	0.41640435101434	HBG1/CLIC2/ALOX5AP/GPX1	4
GO:0001530	lipopolysaccharide binding	3/683	33/18367	0.122994689661176	0.422198097979792	TREM2/PTAFR/TLR2	3
GO:0043130	ubiquitin binding	6/683	92/18367	0.127770458111222	0.429925053763154	CXCR4/UBE2L6/N4BP1/TNFAIP3/TAB2/SQSTM1	6
GO:0005085	guanyl-nucleotide exchange factor activity	12/683	223/18367	0.128728339172653	0.429925053763154	SH3BP5/TAGAP/RAP1A/RIN3/RAPGEF1/RALGDS/DOCK4/LAMTOR5/SOS2/DOCK8/RIN2/ARHGEF40	12
GO:0005149	interleukin-1 receptor binding	2/683	17/18367	0.130112007147746	0.429925053763154	IL1RAP/MYD88	2
GO:0008484	sulfuric ester hydrolase activity	2/683	17/18367	0.130112007147746	0.429925053763154	SULF2/IDS	2
GO:0017081	chloride channel regulator activity	2/683	17/18367	0.130112007147746	0.429925053763154	SGK1/WNK1	2
GO:0031420	alkali metal ion binding	2/683	17/18367	0.130112007147746	0.429925053763154	PKM/SCN9A	2
GO:0032393	MHC class I receptor activity	2/683	17/18367	0.130112007147746	0.429925053763154	CTSH/LILRA5	2
GO:0043395	heparan sulfate proteoglycan binding	2/683	17/18367	0.130112007147746	0.429925053763154	APOE/AGRN	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/683	17/18367	0.130112007147746	0.429925053763154	B3GNT7/B3GNT5	2
GO:0016229	steroid dehydrogenase activity	3/683	34/18367	0.131380188843199	0.429925053763154	HSD17B4/HSD17B11/HSD17B1	3
GO:0030291	protein serine/threonine kinase inhibitor activity	3/683	34/18367	0.131380188843199	0.429925053763154	WNK1/CDKN1A/CDKN1C	3
GO:0045505	dynein intermediate chain binding	3/683	34/18367	0.131380188843199	0.429925053763154	DYNLL1/DYNLT3/DYNLRB1	3
GO:0033293	monocarboxylic acid binding	5/683	73/18367	0.135182681026074	0.43985193642315	APOC1/ALOX5AP/S100A8/STX3/PSAP	5
GO:0008017	microtubule binding	14/683	271/18367	0.135459752120804	0.43985193642315	MX2/MX1/NDRG1/DPYSL2/MAP1LC3B/GAPDH/GABARAPL2/MAPRE1/LRRK2/DST/S100A8/KIF5B/RMDN1/PRNP	14
GO:0004540	ribonuclease activity	7/683	116/18367	0.141317679752162	0.456651120439582	RNASE6/RNASET2/ANG/N4BP1/RPP30/RNASE1/HELZ2	7
GO:0005096	GTPase activator activity	22/683	462/18367	0.14171931323987	0.456651120439582	RGS1/JUN/SH3BP5/ERRFI1/GNAQ/TAGAP/ARHGAP30/RAP1A/RIN3/RAPGEF1/RALGDS/DOCK4/RGS2/LAMTOR5/LRRK2/SOS2/DOCK8/RIN2/IQGAP2/ARHGEF40/SIPA1L1/NRP1	22
GO:0030228	lipoprotein particle receptor activity	2/683	18/18367	0.14293309947778	0.45880433840005	CD36/CXCL16	2
GO:0016791	phosphatase activity	14/683	275/18367	0.146819536819784	0.467993761638887	DUSP1/NT5C3A/FBP1/ACP5/PPP1CB/PPP1R3B/PTP4A2/PTEN/PPP2CB/PTPN12/LRRK2/DUSP2/DUSP18/DUSP6	14
GO:0099106	ion channel regulator activity	8/683	139/18367	0.14690902635028	0.467993761638887	YWHAH/SGK1/CALM1/FXYD5/FLNA/KCNE1/WNK1/KCNAB2	8
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	4/683	55/18367	0.14746533511808	0.467993761638887	HBG1/CLIC2/ALOX5AP/GPX1	4
GO:0003712	transcription coregulator activity	23/683	489/18367	0.148158580269759	0.468426187995741	NUPR1/SAP30/PAGE4/BTG1/TRIM22/NMI/IRF2BP2/DRAP1/CITED2/PARP9/AKIRIN2/EDF1/COPS2/CIR1/ARL2BP/TLE3/RB1/TOB1/PHB/ZBED1/RSF1/HELZ2/XPC	23
GO:0015248	sterol transporter activity	3/683	36/18367	0.148720862296075	0.468442865883892	APOE/TSPO/OSBPL1A	3
GO:0008083	growth factor activity	9/683	162/18367	0.150408923185262	0.471992180592557	VEGFA/TIMP1/TYMP/GMFG/GPI/GRN/IGF2/PPBP/CXCL12	9
GO:0051287	NAD binding	4/683	56/18367	0.154457989505844	0.482896539681838	LDHA/IDH1/GAPDH/ALDH2	4
GO:0000339	RNA cap binding	2/683	19/18367	0.156004544522603	0.485665686989814	IFIT5/EIF4E	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3/683	37/18367	0.157653665336765	0.485665686989814	GAPDH/ALDH2/ALDH3A2	3
GO:0046915	transition metal ion transmembrane transporter activity	3/683	37/18367	0.157653665336765	0.485665686989814	SLC11A1/SLC25A37/ATP2C1	3
GO:0071949	FAD binding	3/683	37/18367	0.157653665336765	0.485665686989814	ERO1A/KDM1B/KMO	3
GO:0019199	transmembrane receptor protein kinase activity	8/683	143/18367	0.164023073435763	0.503443083063782	EIF2AK2/MERTK/EGFR/ACVRL1/PTK2B/EPHB2/RIPK2/NRP1	8
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/683	20/18367	0.169290071169561	0.511645259748591	KLF4/SOCS3	2
GO:0042288	MHC class I protein binding	2/683	20/18367	0.169290071169561	0.511645259748591	PILRA/HLA-E	2
GO:0050145	nucleoside monophosphate kinase activity	2/683	20/18367	0.169290071169561	0.511645259748591	CMPK1/GUK1	2
GO:0097001	ceramide binding	2/683	20/18367	0.169290071169561	0.511645259748591	MAP1LC3B/PSAP	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21/683	450/18367	0.169737250261423	0.511645259748591	ATF5/JUND/JUN/KLF4/PLSCR1/CEBPB/NR4A2/ATF3/KLF6/FOSB/KLF10/MAFB/JUNB/FOS/EGR1/LITAF/SPI1/ZNF395/ZBED1/NR4A1/ZNF438	21
GO:0016247	channel regulator activity	8/683	145/18367	0.172911432635372	0.519351838736956	YWHAH/SGK1/CALM1/FXYD5/FLNA/KCNE1/WNK1/KCNAB2	8
GO:0003697	single-stranded DNA binding	7/683	123/18367	0.174296624111198	0.521649326966254	TERF2IP/CNBP/ANXA1/YBX1/RPA2/HNRNPA1/XPC	7
GO:0098631	cell adhesion mediator activity	4/683	59/18367	0.176146609719064	0.525316662318201	ANXA1/KRT18/S100A11/ANXA2	4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	7/683	124/18367	0.179259799979908	0.530255468727851	EIF2AK2/MERTK/EGFR/PTK2B/EPHB2/RIPK2/NRP1	7
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/683	124/18367	0.179259799979908	0.530255468727851	LDHA/HSD17B4/HSD17B11/IDH1/DHRS3/KCNAB2/HSD17B1	7
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	2/683	21/18367	0.182755752565639	0.530255468727851	AGPAT2/ABHD5	2
GO:0019200	carbohydrate kinase activity	2/683	21/18367	0.182755752565639	0.530255468727851	HK2/GALK1	2
GO:0051010	microtubule plus-end binding	2/683	21/18367	0.182755752565639	0.530255468727851	MAPRE1/DST	2
GO:0001216	DNA-binding transcription activator activity	21/683	456/18367	0.184884275960772	0.530255468727851	ATF5/JUND/JUN/KLF4/PLSCR1/CEBPB/NR4A2/ATF3/KLF6/FOSB/KLF10/MAFB/JUNB/FOS/EGR1/LITAF/SPI1/ZNF395/ZBED1/NR4A1/ZNF438	21
GO:0008238	exopeptidase activity	6/683	103/18367	0.185061842519699	0.530255468727851	CTSH/ANPEP/MMP14/CTSA/TFRC/CPD	6
GO:0004177	aminopeptidase activity	3/683	40/18367	0.185368736986906	0.530255468727851	CTSH/ANPEP/MMP14	3
GO:0015144	carbohydrate transmembrane transporter activity	3/683	40/18367	0.185368736986906	0.530255468727851	SLC2A5/SLC2A3/PPBP	3
GO:0017080	sodium channel regulator activity	3/683	40/18367	0.185368736986906	0.530255468727851	YWHAH/SGK1/FXYD5	3
GO:0042169	SH2 domain binding	3/683	40/18367	0.185368736986906	0.530255468727851	RUFY1/SQSTM1/SIGLEC10	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	3/683	40/18367	0.185368736986906	0.530255468727851	CTSH/RPS27L/PYCARD	3
GO:0009055	electron transfer activity	7/683	126/18367	0.189362082536538	0.539842411570267	NCF1/SDHD/ALDH2/DHRS3/SDHB/CYCS/COX5B	7
GO:0019787	ubiquitin-like protein transferase activity	21/683	458/18367	0.190083071244042	0.540067104446755	HERC5/UBE2L6/TRIM22/SUMO2/UBE2B/TNFAIP3/SMURF2/DTX3L/RBX1/UBE2F/RNF141/UBE2D2/RNF187/ATG3/RNF5/UBE2D1/UBE2Q2/ZBED1/FBXL5/RNF145/HERC6	21
GO:0000062	fatty-acyl-CoA binding	2/683	22/18367	0.196369882346235	0.54700269001304	SOAT1/ACBD5	2
GO:0005416	amino acid:cation symporter activity	2/683	22/18367	0.196369882346235	0.54700269001304	SLC1A3/SLC38A2	2
GO:0008320	protein transmembrane transporter activity	2/683	22/18367	0.196369882346235	0.54700269001304	MCL1/SEC61G	2
GO:0070034	telomerase RNA binding	2/683	22/18367	0.196369882346235	0.54700269001304	SNRPB/NOP10	2
GO:0120020	cholesterol transfer activity	2/683	22/18367	0.196369882346235	0.54700269001304	APOE/TSPO	2
GO:1990782	protein tyrosine kinase binding	6/683	105/18367	0.196426649683636	0.54700269001304	TREM2/PTEN/DOCK4/DAZAP2/SQSTM1/TOB1	6
GO:0030165	PDZ domain binding	5/683	84/18367	0.202606066382265	0.562348850915792	CADM1/GNG5/PTEN/DOCK4/LIN7C	5
GO:0042578	phosphoric ester hydrolase activity	17/683	366/18367	0.20560117019308	0.566334944147121	DUSP1/NT5C3A/FBP1/ACP5/PPP1CB/PPP1R3B/PTP4A2/PTEN/HMOX1/PPP2CB/PTPN12/GPCPD1/LRRK2/DUSP2/DUSP18/PLD3/DUSP6	17
GO:0005158	insulin receptor binding	2/683	23/18367	0.210102856806066	0.566334944147121	IRS2/IGF2	2
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	2/683	23/18367	0.210102856806066	0.566334944147121	ALOX5/ALOX5AP	2
GO:0017025	TBP-class protein binding	2/683	23/18367	0.210102856806066	0.566334944147121	AHR/DRAP1	2
GO:0042171	lysophosphatidic acid acyltransferase activity	2/683	23/18367	0.210102856806066	0.566334944147121	AGPAT2/ABHD5	2
GO:0070412	R-SMAD binding	2/683	23/18367	0.210102856806066	0.566334944147121	JUN/FOS	2
GO:0071617	lysophospholipid acyltransferase activity	2/683	23/18367	0.210102856806066	0.566334944147121	AGPAT2/ABHD5	2
GO:0120015	sterol transfer activity	2/683	23/18367	0.210102856806066	0.566334944147121	APOE/TSPO	2
GO:1901567	fatty acid derivative binding	2/683	23/18367	0.210102856806066	0.566334944147121	SOAT1/ACBD5	2
GO:0005516	calmodulin binding	10/683	201/18367	0.216352662441636	0.581318176081201	RGS1/MYO1G/KCNQ3/RGS2/EGFR/EPB41/EDF1/CAMK1/IQGAP2/MARCKS	10
GO:0016779	nucleotidyltransferase activity	7/683	132/18367	0.220974017207587	0.583380877239035	OAS2/OAS1/OAS3/PAPSS1/PAPSS2/PTGES3/POLR2E	7
GO:0001965	G-protein alpha-subunit binding	2/683	24/18367	0.223927062742444	0.583380877239035	RGS1/RGS2	2
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	2/683	24/18367	0.223927062742444	0.583380877239035	ALOX5/ALOX5AP	2
GO:0019789	SUMO transferase activity	2/683	24/18367	0.223927062742444	0.583380877239035	SUMO2/ZBED1	2
GO:0019957	C-C chemokine binding	2/683	24/18367	0.223927062742444	0.583380877239035	CXCR4/ZFP36	2
GO:0050431	transforming growth factor beta binding	2/683	24/18367	0.223927062742444	0.583380877239035	CD36/ACVRL1	2
GO:0051537	2 iron, 2 sulfur cluster binding	2/683	24/18367	0.223927062742444	0.583380877239035	CISD2/SDHB	2
GO:0001784	phosphotyrosine residue binding	3/683	44/18367	0.224057102673256	0.583380877239035	GRB2/SOCS3/SAMSN1	3
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3/683	44/18367	0.224057102673256	0.583380877239035	GAPDH/ALDH2/ALDH3A2	3
GO:0051879	Hsp90 protein binding	3/683	44/18367	0.224057102673256	0.583380877239035	AHR/GBP1/PTGES3	3
GO:0004866	endopeptidase inhibitor activity	9/683	180/18367	0.227977921444363	0.591757505971324	TIMP1/CARD16/SERPING1/BST2/GAPDH/CSTB/ANXA2/SERPINB1/PRNP	9
GO:0051219	phosphoprotein binding	5/683	88/18367	0.229509579280765	0.593900172846534	GRB2/SOCS3/SAMSN1/EPB41/RB1	5
GO:0032182	ubiquitin-like protein binding	6/683	111/18367	0.231973042517029	0.598433523793931	CXCR4/UBE2L6/N4BP1/TNFAIP3/TAB2/SQSTM1	6
GO:0004715	non-membrane spanning protein tyrosine kinase activity	3/683	45/18367	0.233969318215614	0.598814084340036	EIF2AK2/PTK2B/RIPK2	3
GO:0016853	isomerase activity	8/683	158/18367	0.235458400046551	0.598814084340036	ERO1A/HSD17B4/TPI1/MIF/FKBP5/GPI/PTGES3/PGAM1	8
GO:0003735	structural constituent of ribosome	9/683	182/18367	0.237410700723136	0.598814084340036	ISG15/RPS27L/MRPS18C/MRPS18B/RPL26L1/RPL36AL/MRPL18/MRPL43/RPL39	9
GO:0005160	transforming growth factor beta receptor binding	2/683	25/18367	0.237816770712928	0.598814084340036	SMURF2/SMAD7	2
GO:0008266	poly(U) RNA binding	2/683	25/18367	0.237816770712928	0.598814084340036	IFIT5/SSB	2
GO:0008327	methyl-CpG binding	2/683	25/18367	0.237816770712928	0.598814084340036	ZBTB4/ERH	2
GO:0051019	mitogen-activated protein kinase binding	2/683	25/18367	0.237816770712928	0.598814084340036	DUSP1/PTAFR	2
GO:0120227	acyl-CoA binding	2/683	25/18367	0.237816770712928	0.598814084340036	SOAT1/ACBD5	2
GO:0046982	protein heterodimerization activity	15/683	328/18367	0.241297566411899	0.60576493538032	YWHAH/CEBPB/NR4A2/ATF3/AHR/BHLHE40/DRAP1/MCL1/SDCBP/RRAGD/SOS2/PHB/NR4A1/LSM6/BCL2A1	15
GO:0004713	protein tyrosine kinase activity	7/683	136/18367	0.243016261454114	0.608263916318185	EIF2AK2/MERTK/EGFR/PTK2B/EPHB2/RIPK2/NRP1	7
GO:0140296	general transcription initiation factor binding	3/683	46/18367	0.243957575815351	0.608808074957596	AHR/DRAP1/EDF1	3
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2/683	26/18367	0.251748033460692	0.622706165118946	GLUL/ZDHHC20	2
GO:0019707	protein-cysteine S-acyltransferase activity	2/683	26/18367	0.251748033460692	0.622706165118946	GLUL/ZDHHC20	2
GO:0030371	translation repressor activity	2/683	26/18367	0.251748033460692	0.622706165118946	EIF4EBP1/CPEB2	2
GO:0004521	endoribonuclease activity	4/683	69/18367	0.254566717894658	0.625995934939789	RNASET2/ANG/RPP30/RNASE1	4
GO:0005518	collagen binding	4/683	69/18367	0.254566717894658	0.625995934939789	CD44/TGFBI/FN1/SMAD7	4
GO:0051213	dioxygenase activity	5/683	92/18367	0.257369457022135	0.631042896080511	ALOX5/EGLN3/P4HA1/ALOX5AP/EGLN1	5
GO:0030414	peptidase inhibitor activity	9/683	187/18367	0.261572749678608	0.633009953477442	TIMP1/CARD16/SERPING1/BST2/GAPDH/CSTB/ANXA2/SERPINB1/PRNP	9
GO:0015026	coreceptor activity	3/683	48/18367	0.264124045502895	0.633009953477442	CXCR4/CD86/NRP1	3
GO:0048020	CCR chemokine receptor binding	3/683	48/18367	0.264124045502895	0.633009953477442	STAT1/CNIH4/CCL13	3
GO:0070888	E-box binding	3/683	48/18367	0.264124045502895	0.633009953477442	AHR/BHLHE40/PER1	3
GO:0072341	modified amino acid binding	5/683	93/18367	0.264459848714198	0.633009953477442	TREM2/CD300A/FCHO2/ANXA2/SCARB2	5
GO:0004683	calmodulin-dependent protein kinase activity	2/683	27/18367	0.265698589271745	0.633009953477442	CAMK1/PTK2B	2
GO:0022884	macromolecule transmembrane transporter activity	2/683	27/18367	0.265698589271745	0.633009953477442	MCL1/SEC61G	2
GO:0030507	spectrin binding	2/683	27/18367	0.265698589271745	0.633009953477442	GBP1/EPB41	2
GO:0035255	ionotropic glutamate receptor binding	2/683	27/18367	0.265698589271745	0.633009953477442	PTEN/SQSTM1	2
GO:0070006	metalloaminopeptidase activity	2/683	27/18367	0.265698589271745	0.633009953477442	ANPEP/MMP14	2
GO:0019838	growth factor binding	7/683	141/18367	0.271480348422687	0.641484238413689	DUSP1/CD36/EGFR/SDCBP/ACVRL1/HAX1/NRP1	7
GO:0008234	cysteine-type peptidase activity	9/683	190/18367	0.276428119427788	0.641484238413689	CAPN2/CTSH/OTUD1/PYCARD/TNFAIP3/USP18/CTSD/TANK/CAPNS1	9
GO:0008235	metalloexopeptidase activity	4/683	72/18367	0.279389296456193	0.641484238413689	ANPEP/MMP14/TFRC/CPD	4
GO:0008187	poly-pyrimidine tract binding	2/683	28/18367	0.2796477700385	0.641484238413689	IFIT5/SSB	2
GO:0051861	glycolipid binding	2/683	28/18367	0.2796477700385	0.641484238413689	TREM2/PSAP	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	2/683	28/18367	0.2796477700385	0.641484238413689	WDR45B/WIPI2	2
GO:0008236	serine-type peptidase activity	9/683	191/18367	0.281433521532123	0.641484238413689	CTSH/ADAM8/ST14/CFD/MMP19/MMP14/CTSA/PLAU/CPD	9
GO:0004197	cysteine-type endopeptidase activity	6/683	119/18367	0.282114809913273	0.641484238413689	CAPN2/CTSH/PYCARD/USP18/CTSD/CAPNS1	6
GO:0005048	signal sequence binding	3/683	50/18367	0.284482674328199	0.641484238413689	NFKBIA/NUP58/KPNA3	3
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	3/683	50/18367	0.284482674328199	0.641484238413689	IL1RAP/MYD88/TLR2	3
GO:0140104	molecular carrier activity	4/683	73/18367	0.287749100249244	0.641484238413689	HBG1/SCO2/KPNA3/TIMM10	4
GO:0016922	nuclear receptor binding	7/683	144/18367	0.288966654800156	0.641484238413689	JUND/YWHAH/STAT1/CEBPB/NR4A2/OASL/NR4A1	7
GO:0004033	aldo-keto reductase (NADP) activity	2/683	29/18367	0.293576413814105	0.641484238413689	DHRS3/KCNAB2	2
GO:0032452	histone demethylase activity	2/683	29/18367	0.293576413814105	0.641484238413689	KDM1B/JARID2	2
GO:0035250	UDP-galactosyltransferase activity	2/683	29/18367	0.293576413814105	0.641484238413689	B3GNT7/B3GNT5	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/683	29/18367	0.293576413814105	0.641484238413689	MYO1G/NCF1	2
GO:0046625	sphingolipid binding	2/683	29/18367	0.293576413814105	0.641484238413689	MAP1LC3B/PSAP	2
GO:0140457	protein demethylase activity	2/683	29/18367	0.293576413814105	0.641484238413689	KDM1B/JARID2	2
GO:0005254	chloride channel activity	4/683	74/18367	0.296143601099221	0.641484238413689	CLIC2/CLIC1/GABRB2/TTYH3	4
GO:0017171	serine hydrolase activity	9/683	195/18367	0.301695670382554	0.641484238413689	CTSH/ADAM8/ST14/CFD/MMP19/MMP14/CTSA/PLAU/CPD	9
GO:0004879	nuclear receptor activity	3/683	52/18367	0.304963791560913	0.641484238413689	NR4A2/AHR/NR4A1	3
GO:0016597	amino acid binding	3/683	52/18367	0.304963791560913	0.641484238413689	GLUL/SLC1A3/DDAH2	3
GO:0031593	polyubiquitin modification-dependent protein binding	3/683	52/18367	0.304963791560913	0.641484238413689	TNFAIP3/TAB2/SQSTM1	3
GO:0098531	ligand-activated transcription factor activity	3/683	52/18367	0.304963791560913	0.641484238413689	NR4A2/AHR/NR4A1	3
GO:0005343	organic acid:sodium symporter activity	2/683	30/18367	0.307466781651442	0.641484238413689	SLC1A3/SLC38A2	2
GO:0016417	S-acyltransferase activity	2/683	30/18367	0.307466781651442	0.641484238413689	GLUL/ZDHHC20	2
GO:0050661	NADP binding	3/683	53/18367	0.315229691987397	0.641484238413689	IDH1/GAPDH/HSD17B1	3
GO:0004300	enoyl-CoA hydratase activity	1/683	10/18367	0.315487013347859	0.641484238413689	HSD17B4	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/683	10/18367	0.315487013347859	0.641484238413689	PRKX	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/683	10/18367	0.315487013347859	0.641484238413689	PTPN12	1
GO:0005031	tumor necrosis factor-activated receptor activity	1/683	10/18367	0.315487013347859	0.641484238413689	TNFRSF14	1
GO:0005522	profilin binding	1/683	10/18367	0.315487013347859	0.641484238413689	WIPF1	1
GO:0005528	FK506 binding	1/683	10/18367	0.315487013347859	0.641484238413689	FKBP5	1
GO:0008097	5S rRNA binding	1/683	10/18367	0.315487013347859	0.641484238413689	MRPL18	1
GO:0008190	eukaryotic initiation factor 4E binding	1/683	10/18367	0.315487013347859	0.641484238413689	EIF4EBP1	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/683	10/18367	0.315487013347859	0.641484238413689	UBA6	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/683	10/18367	0.315487013347859	0.641484238413689	SLC16A10	1
GO:0015279	store-operated calcium channel activity	1/683	10/18367	0.315487013347859	0.641484238413689	ORAI3	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/683	10/18367	0.315487013347859	0.641484238413689	NCF1	1
GO:0016176	superoxide-generating NADPH oxidase activator activity	1/683	10/18367	0.315487013347859	0.641484238413689	NCF1	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/683	10/18367	0.315487013347859	0.641484238413689	PIK3CB	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/683	10/18367	0.315487013347859	0.641484238413689	SCD	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/683	10/18367	0.315487013347859	0.641484238413689	PGAM1	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/683	10/18367	0.315487013347859	0.641484238413689	GATC	1
GO:0017002	activin-activated receptor activity	1/683	10/18367	0.315487013347859	0.641484238413689	ACVRL1	1
GO:0019203	carbohydrate phosphatase activity	1/683	10/18367	0.315487013347859	0.641484238413689	FBP1	1
GO:0019869	chloride channel inhibitor activity	1/683	10/18367	0.315487013347859	0.641484238413689	WNK1	1
GO:0030957	Tat protein binding	1/683	10/18367	0.315487013347859	0.641484238413689	MDFIC	1
GO:0031419	cobalamin binding	1/683	10/18367	0.315487013347859	0.641484238413689	TCN2	1
GO:0031720	haptoglobin binding	1/683	10/18367	0.315487013347859	0.641484238413689	HBG1	1
GO:0033204	ribonuclease P RNA binding	1/683	10/18367	0.315487013347859	0.641484238413689	RPP30	1
GO:0034713	type I transforming growth factor beta receptor binding	1/683	10/18367	0.315487013347859	0.641484238413689	SMAD7	1
GO:0035374	chondroitin sulfate binding	1/683	10/18367	0.315487013347859	0.641484238413689	AGRN	1
GO:0043208	glycosphingolipid binding	1/683	10/18367	0.315487013347859	0.641484238413689	PSAP	1
GO:0045503	dynein light chain binding	1/683	10/18367	0.315487013347859	0.641484238413689	GLUL	1
GO:0050308	sugar-phosphatase activity	1/683	10/18367	0.315487013347859	0.641484238413689	FBP1	1
GO:0051880	G-quadruplex DNA binding	1/683	10/18367	0.315487013347859	0.641484238413689	CNBP	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/683	10/18367	0.315487013347859	0.641484238413689	PIK3CB	1
GO:0071723	lipopeptide binding	1/683	10/18367	0.315487013347859	0.641484238413689	TLR2	1
GO:0043021	ribonucleoprotein complex binding	7/683	149/18367	0.318647372423091	0.641484238413689	IFIH1/YBX3/CSNK2B/SNRPB/OLA1/TMEM147/CPEB2	7
GO:0000146	microfilament motor activity	2/683	31/18367	0.321302478529772	0.641484238413689	MYO1G/MYL6	2
GO:0016411	acylglycerol O-acyltransferase activity	2/683	31/18367	0.321302478529772	0.641484238413689	AGPAT2/ABHD5	2
GO:0031210	phosphatidylcholine binding	2/683	31/18367	0.321302478529772	0.641484238413689	APOC1/SCARB2	2
GO:0043015	gamma-tubulin binding	2/683	31/18367	0.321302478529772	0.641484238413689	NDRG1/BLOC1S2	2
GO:0090482	vitamin transmembrane transporter activity	2/683	31/18367	0.321302478529772	0.641484238413689	SLC2A3/SLC25A19	2
GO:0008374	O-acyltransferase activity	3/683	54/18367	0.325502055217919	0.641484238413689	SOAT1/AGPAT2/ABHD5	3
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/683	54/18367	0.325502055217919	0.641484238413689	EGLN3/P4HA1/EGLN1	3
GO:0001221	transcription coregulator binding	4/683	78/18367	0.329974764493953	0.641484238413689	STAT1/KLF4/AHR/PER1	4
GO:0030971	receptor tyrosine kinase binding	4/683	78/18367	0.329974764493953	0.641484238413689	DOCK4/DAZAP2/SQSTM1/TOB1	4
GO:0042826	histone deacetylase binding	6/683	127/18367	0.334362458250818	0.641484238413689	KLF4/CEBPB/RAC1/SPI1/CIR1/PHB	6
GO:0001222	transcription corepressor binding	2/683	32/18367	0.335068378180721	0.641484238413689	STAT1/PER1	2
GO:0008378	galactosyltransferase activity	2/683	32/18367	0.335068378180721	0.641484238413689	B3GNT7/B3GNT5	2
GO:0030332	cyclin binding	2/683	32/18367	0.335068378180721	0.641484238413689	CDKN1A/MDFIC	2
GO:0050699	WW domain binding	2/683	32/18367	0.335068378180721	0.641484238413689	LITAF/DAZAP2	2
GO:0051721	protein phosphatase 2A binding	2/683	32/18367	0.335068378180721	0.641484238413689	STAT1/EIF4EBP1	2
GO:0005080	protein kinase C binding	3/683	55/18367	0.335773404454449	0.641484238413689	FLNA/SQSTM1/MARCKS	3
GO:0008503	benzodiazepine receptor activity	1/683	11/18367	0.340955356207989	0.641484238413689	TSPO	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/683	11/18367	0.340955356207989	0.641484238413689	ERO1A	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/683	11/18367	0.340955356207989	0.641484238413689	DDAH2	1
GO:0016832	aldehyde-lyase activity	1/683	11/18367	0.340955356207989	0.641484238413689	ALDOA	1
GO:0017128	phospholipid scramblase activity	1/683	11/18367	0.340955356207989	0.641484238413689	PLSCR1	1
GO:0019107	myristoyltransferase activity	1/683	11/18367	0.340955356207989	0.641484238413689	ZDHHC20	1
GO:0019855	calcium channel inhibitor activity	1/683	11/18367	0.340955356207989	0.641484238413689	CALM1	1
GO:0022889	serine transmembrane transporter activity	1/683	11/18367	0.340955356207989	0.641484238413689	SLC38A2	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/683	11/18367	0.340955356207989	0.641484238413689	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/683	11/18367	0.340955356207989	0.641484238413689	TRIB1	1
GO:0031996	thioesterase binding	1/683	11/18367	0.340955356207989	0.641484238413689	RAC1	1
GO:0043560	insulin receptor substrate binding	1/683	11/18367	0.340955356207989	0.641484238413689	GRB2	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/683	11/18367	0.340955356207989	0.641484238413689	SETD2	1
GO:0047676	arachidonate-CoA ligase activity	1/683	11/18367	0.340955356207989	0.641484238413689	ACSL1	1
GO:0061665	SUMO ligase activity	1/683	11/18367	0.340955356207989	0.641484238413689	ZBED1	1
GO:0070513	death domain binding	1/683	11/18367	0.340955356207989	0.641484238413689	MCL1	1
GO:1901474	azole transmembrane transporter activity	1/683	11/18367	0.340955356207989	0.641484238413689	SLC25A19	1
GO:1990459	transferrin receptor binding	1/683	11/18367	0.340955356207989	0.641484238413689	CD81	1
GO:0045309	protein phosphorylated amino acid binding	3/683	56/18367	0.346036541149653	0.64745963338599	GRB2/SOCS3/SAMSN1	3
GO:0031072	heat shock protein binding	6/683	129/18367	0.347622365699831	0.64745963338599	AHR/ZFP36/FKBP5/GBP1/ITGAM/PTGES3	6
GO:0005154	epidermal growth factor receptor binding	2/683	33/18367	0.348750551633595	0.64745963338599	PLSCR1/GRB2	2
GO:0005251	delayed rectifier potassium channel activity	2/683	33/18367	0.348750551633595	0.64745963338599	KCNQ3/KCNE1	2
GO:0008200	ion channel inhibitor activity	2/683	33/18367	0.348750551633595	0.64745963338599	CALM1/WNK1	2
GO:0031369	translation initiation factor binding	2/683	33/18367	0.348750551633595	0.64745963338599	EIF4EBP1/EIF4E	2
GO:0016248	channel inhibitor activity	2/683	34/18367	0.362336199307995	0.652582871788377	CALM1/WNK1	2
GO:0004674	protein serine/threonine kinase activity	16/683	386/18367	0.364024826314982	0.652582871788377	EIF2AK2/SGK1/CSNK2B/PRKX/EGFR/MAP3K2/LRRK2/WNK1/PLK3/MAP3K3/CAMK1/ACVRL1/PTK2B/SQSTM1/FAM20C/RIPK2	16
GO:0000340	RNA 7-methylguanosine cap binding	1/683	12/18367	0.365477446625833	0.652582871788377	EIF4E	1
GO:0003964	RNA-directed DNA polymerase activity	1/683	12/18367	0.365477446625833	0.652582871788377	PTGES3	1
GO:0004526	ribonuclease P activity	1/683	12/18367	0.365477446625833	0.652582871788377	RPP30	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/683	12/18367	0.365477446625833	0.652582871788377	ACVRL1	1
GO:0005165	neurotrophin receptor binding	1/683	12/18367	0.365477446625833	0.652582871788377	GRB2	1
GO:0005527	macrolide binding	1/683	12/18367	0.365477446625833	0.652582871788377	FKBP5	1
GO:0015269	calcium-activated potassium channel activity	1/683	12/18367	0.365477446625833	0.652582871788377	KCNMA1	1
GO:0015651	quaternary ammonium group transmembrane transporter activity	1/683	12/18367	0.365477446625833	0.652582871788377	SLC25A19	1
GO:0017154	semaphorin receptor activity	1/683	12/18367	0.365477446625833	0.652582871788377	NRP1	1
GO:0030955	potassium ion binding	1/683	12/18367	0.365477446625833	0.652582871788377	PKM	1
GO:0032396	inhibitory MHC class I receptor activity	1/683	12/18367	0.365477446625833	0.652582871788377	LILRA5	1
GO:0033130	acetylcholine receptor binding	1/683	12/18367	0.365477446625833	0.652582871788377	LY6E	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/683	12/18367	0.365477446625833	0.652582871788377	PIK3CB	1
GO:0046790	virion binding	1/683	12/18367	0.365477446625833	0.652582871788377	ANXA2	1
GO:0061578	Lys63-specific deubiquitinase activity	1/683	12/18367	0.365477446625833	0.652582871788377	TNFAIP3	1
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	1/683	12/18367	0.365477446625833	0.652582871788377	KCNE1	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/683	58/18367	0.36651077086921	0.653041437078401	SLC16A3/CD36/ABCC3	3
GO:0004518	nuclease activity	9/683	210/18367	0.380114405961191	0.674687294321334	RNASE6/PLSCR1/RNASET2/ANG/N4BP1/RPP30/RNASE1/HELZ2/PLD3	9
GO:0042626	ATPase-coupled transmembrane transporter activity	5/683	109/18367	0.381760383980592	0.674687294321334	ATP6V1F/ATP6V1G1/ABCC3/ATP6V1B2/ATP2C1	5
GO:0005035	death receptor activity	1/683	13/18367	0.389088392087809	0.674687294321334	TNFRSF14	1
GO:0008253	5'-nucleotidase activity	1/683	13/18367	0.389088392087809	0.674687294321334	NT5C3A	1
GO:0008494	translation activator activity	1/683	13/18367	0.389088392087809	0.674687294321334	RPS27L	1
GO:0022851	GABA-gated chloride ion channel activity	1/683	13/18367	0.389088392087809	0.674687294321334	GABRB2	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/683	13/18367	0.389088392087809	0.674687294321334	RBX1	1
GO:0039706	co-receptor binding	1/683	13/18367	0.389088392087809	0.674687294321334	LRRK2	1
GO:0045159	myosin II binding	1/683	13/18367	0.389088392087809	0.674687294321334	GSN	1
GO:0052650	NADP-retinol dehydrogenase activity	1/683	13/18367	0.389088392087809	0.674687294321334	DHRS3	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/683	13/18367	0.389088392087809	0.674687294321334	CCNY	1
GO:0061783	peptidoglycan muralytic activity	1/683	13/18367	0.389088392087809	0.674687294321334	LYZ	1
GO:0070700	BMP receptor binding	1/683	13/18367	0.389088392087809	0.674687294321334	PYCARD	1
GO:0042562	hormone binding	4/683	86/18367	0.397942604507721	0.688620844425913	CTSH/TSPO/EGFR/EBI3	4
GO:0016409	palmitoyltransferase activity	2/683	37/18367	0.402401600126874	0.692684602953782	GLUL/ZDHHC20	2
GO:0005253	anion channel activity	4/683	87/18367	0.406388703483075	0.692684602953782	CLIC2/CLIC1/GABRB2/TTYH3	4
GO:1990841	promoter-specific chromatin binding	3/683	62/18367	0.407074595043391	0.692684602953782	STAT1/KLF4/EGR1	3
GO:0004065	arylsulfatase activity	1/683	14/18367	0.411821999377992	0.692684602953782	SULF2	1
GO:0005172	vascular endothelial growth factor receptor binding	1/683	14/18367	0.411821999377992	0.692684602953782	VEGFA	1
GO:0005313	L-glutamate transmembrane transporter activity	1/683	14/18367	0.411821999377992	0.692684602953782	SLC1A3	1
GO:0005344	oxygen carrier activity	1/683	14/18367	0.411821999377992	0.692684602953782	HBG1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/683	14/18367	0.411821999377992	0.692684602953782	MIF	1
GO:0030983	mismatched DNA binding	1/683	14/18367	0.411821999377992	0.692684602953782	XPC	1
GO:0032977	membrane insertase activity	1/683	14/18367	0.411821999377992	0.692684602953782	TIMM10	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/683	14/18367	0.411821999377992	0.692684602953782	PTAFR	1
GO:0070411	I-SMAD binding	1/683	14/18367	0.411821999377992	0.692684602953782	SMAD7	1
GO:0071837	HMG box domain binding	1/683	14/18367	0.411821999377992	0.692684602953782	JUN	1
GO:0140666	annealing activity	1/683	14/18367	0.411821999377992	0.692684602953782	ANXA1	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/683	38/18367	0.415493545029312	0.693442589145471	DRAP1/SNAPC2	2
GO:0045182	translation regulator activity	6/683	140/18367	0.420932071003653	0.693442589145471	EIF2AK2/RPS27L/CNBP/EIF4EBP1/EIF4E/CPEB2	6
GO:0030674	protein-macromolecule adaptor activity	12/683	296/18367	0.421554394001181	0.693442589145471	DAB2/KLF4/TRIM22/ARPC4/GRB2/ABI1/LRRK2/SERINC1/SDCBP/PSMC6/STX3/APH1A	12
GO:0016757	glycosyltransferase activity	11/683	270/18367	0.422083045407936	0.693442589145471	TYMP/UPP1/ST8SIA4/NAMPT/PARP9/B3GNT7/PARP12/GCNT1/HEXB/TIPARP/B3GNT5	11
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/683	39/18367	0.428439758544526	0.693442589145471	MYO1G/IQGAP2	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/683	39/18367	0.428439758544526	0.693442589145471	CMPK1/GUK1	2
GO:0019825	oxygen binding	2/683	39/18367	0.428439758544526	0.693442589145471	SOD2/HBG1	2
GO:0032451	demethylase activity	2/683	39/18367	0.428439758544526	0.693442589145471	KDM1B/JARID2	2
GO:0050997	quaternary ammonium group binding	2/683	39/18367	0.428439758544526	0.693442589145471	APOC1/SCARB2	2
GO:0005249	voltage-gated potassium channel activity	4/683	90/18367	0.431573964818154	0.693442589145471	KCNQ3/KCNE1/KCNAB2/KCNMA1	4
GO:0004175	endopeptidase activity	17/683	430/18367	0.432962617148052	0.693442589145471	CAPN2/PSMB9/CTSH/ADAM8/ADAM28/ST14/CFD/PSMB8/PSMB10/PYCARD/MMP19/USP18/CTSD/MMP14/CAPNS1/PLAU/TMEM59	17
GO:0004467	long-chain fatty acid-CoA ligase activity	1/683	15/18367	0.433710822699783	0.693442589145471	ACSL1	1
GO:0004549	tRNA-specific ribonuclease activity	1/683	15/18367	0.433710822699783	0.693442589145471	RPP30	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/683	15/18367	0.433710822699783	0.693442589145471	GABRB2	1
GO:0008252	nucleotidase activity	1/683	15/18367	0.433710822699783	0.693442589145471	NT5C3A	1
GO:0008559	ABC-type xenobiotic transporter activity	1/683	15/18367	0.433710822699783	0.693442589145471	ABCC3	1
GO:0015929	hexosaminidase activity	1/683	15/18367	0.433710822699783	0.693442589145471	HEXB	1
GO:0016846	carbon-sulfur lyase activity	1/683	15/18367	0.433710822699783	0.693442589145471	ALOX5AP	1
GO:0019215	intermediate filament binding	1/683	15/18367	0.433710822699783	0.693442589145471	VIM	1
GO:0030548	acetylcholine receptor regulator activity	1/683	15/18367	0.433710822699783	0.693442589145471	LY6E	1
GO:0042043	neurexin family protein binding	1/683	15/18367	0.433710822699783	0.693442589145471	SDCBP	1
GO:0051139	metal ion:proton antiporter activity	1/683	15/18367	0.433710822699783	0.693442589145471	SLC11A1	1
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	1/683	15/18367	0.433710822699783	0.693442589145471	KCNE1	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/683	15/18367	0.433710822699783	0.693442589145471	PYCARD	1
GO:0099602	neurotransmitter receptor regulator activity	1/683	15/18367	0.433710822699783	0.693442589145471	LY6E	1
GO:1990825	sequence-specific mRNA binding	1/683	15/18367	0.433710822699783	0.693442589145471	SSB	1
GO:0030145	manganese ion binding	3/683	65/18367	0.436983541522452	0.697349446717992	GLUL/SOD2/FAM20C	3
GO:0000287	magnesium ion binding	9/683	221/18367	0.438594367668106	0.6985944378956	NT5C3A/PLSCR1/GLUL/PKM/IDH1/ENO1/LRRK2/ENO2/WNK1	9
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/683	40/18367	0.441232970205453	0.701468672859709	HMOX1/CYP1B1	2
GO:0004842	ubiquitin-protein transferase activity	17/683	433/18367	0.444376773274705	0.703079416593034	HERC5/UBE2L6/TRIM22/UBE2B/TNFAIP3/SMURF2/DTX3L/RBX1/RNF141/UBE2D2/RNF187/RNF5/UBE2D1/UBE2Q2/FBXL5/RNF145/HERC6	17
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	7/683	170/18367	0.446395624317706	0.703079416593034	EGLN3/SCD/P4HA1/HMOX1/EGLN1/CYP1B1/KMO	7
GO:0043022	ribosome binding	3/683	66/18367	0.446828743816631	0.703079416593034	OLA1/TMEM147/CPEB2	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/683	41/18367	0.453866649978394	0.703079416593034	ACSL1/UBA6	2
GO:0048487	beta-tubulin binding	2/683	41/18367	0.453866649978394	0.703079416593034	GABARAPL2/RGS2	2
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/683	16/18367	0.454786210019751	0.703079416593034	CPEB2	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/683	16/18367	0.454786210019751	0.703079416593034	SLC1A3	1
GO:0016208	AMP binding	1/683	16/18367	0.454786210019751	0.703079416593034	FBP1	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/683	16/18367	0.454786210019751	0.703079416593034	IL4I1	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	1/683	16/18367	0.454786210019751	0.703079416593034	RNASE1	1
GO:0017070	U6 snRNA binding	1/683	16/18367	0.454786210019751	0.703079416593034	LARP7	1
GO:0019841	retinol binding	1/683	16/18367	0.454786210019751	0.703079416593034	RBP1	1
GO:0035497	cAMP response element binding	1/683	16/18367	0.454786210019751	0.703079416593034	JUN	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/683	16/18367	0.454786210019751	0.703079416593034	SOCS3	1
GO:0070492	oligosaccharide binding	1/683	16/18367	0.454786210019751	0.703079416593034	LGALS1	1
GO:0005201	extracellular matrix structural constituent	7/683	172/18367	0.458498514204423	0.707517890726458	VCAN/FGL2/ECM1/FBN2/TGFBI/FN1/AGRN	7
GO:0019843	rRNA binding	3/683	68/18367	0.466306349317549	0.709664103756785	ANG/MRPS18C/MRPL18	3
GO:0051536	iron-sulfur cluster binding	3/683	68/18367	0.466306349317549	0.709664103756785	RSAD2/CISD2/SDHB	3
GO:0051540	metal cluster binding	3/683	68/18367	0.466306349317549	0.709664103756785	RSAD2/CISD2/SDHB	3
GO:0008307	structural constituent of muscle	2/683	42/18367	0.466334963390125	0.709664103756785	PLEC/MYL6	2
GO:0019205	nucleobase-containing compound kinase activity	2/683	42/18367	0.466334963390125	0.709664103756785	CMPK1/GUK1	2
GO:0051539	4 iron, 4 sulfur cluster binding	2/683	42/18367	0.466334963390125	0.709664103756785	RSAD2/SDHB	2
GO:0004252	serine-type endopeptidase activity	7/683	174/18367	0.470544572312805	0.709664103756785	CTSH/ADAM8/ST14/CFD/MMP19/MMP14/PLAU	7
GO:0005244	voltage-gated ion channel activity	8/683	201/18367	0.473287992122597	0.709664103756785	KCNQ3/CLIC2/CLIC1/KCNE1/KCNAB2/PTK2B/KCNMA1/SCN9A	8
GO:0022832	voltage-gated channel activity	8/683	201/18367	0.473287992122597	0.709664103756785	KCNQ3/CLIC2/CLIC1/KCNE1/KCNAB2/PTK2B/KCNMA1/SCN9A	8
GO:0005005	transmembrane-ephrin receptor activity	1/683	17/18367	0.475078347699251	0.709664103756785	EPHB2	1
GO:0005324	long-chain fatty acid transporter activity	1/683	17/18367	0.475078347699251	0.709664103756785	CD36	1
GO:0008574	plus-end-directed microtubule motor activity	1/683	17/18367	0.475078347699251	0.709664103756785	KIF5B	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/683	17/18367	0.475078347699251	0.709664103756785	FTH1	1
GO:0031489	myosin V binding	1/683	17/18367	0.475078347699251	0.709664103756785	RAB8A	1
GO:0034185	apolipoprotein binding	1/683	17/18367	0.475078347699251	0.709664103756785	TREM2	1
GO:0043024	ribosomal small subunit binding	1/683	17/18367	0.475078347699251	0.709664103756785	CPEB2	1
GO:0046965	retinoid X receptor binding	1/683	17/18367	0.475078347699251	0.709664103756785	NR4A2	1
GO:0052745	inositol phosphate phosphatase activity	1/683	17/18367	0.475078347699251	0.709664103756785	PTEN	1
GO:0004180	carboxypeptidase activity	2/683	43/18367	0.478632728960466	0.709929673819669	CTSA/CPD	2
GO:0005246	calcium channel regulator activity	2/683	43/18367	0.478632728960466	0.709929673819669	SGK1/CALM1	2
GO:0016790	thiolester hydrolase activity	2/683	43/18367	0.478632728960466	0.709929673819669	ESD/HAGH	2
GO:0032266	phosphatidylinositol-3-phosphate binding	2/683	43/18367	0.478632728960466	0.709929673819669	WDR45B/WIPI2	2
GO:0046906	tetrapyrrole binding	6/683	149/18367	0.480156378959979	0.710935765326307	HBG1/SDHD/HMOX1/CYCS/TCN2/CYP1B1	6
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	12/683	310/18367	0.485153067015995	0.713503106730951	JUN/CEBPB/ATF3/MXI1/BHLHE40/SKIL/NFIL3/ENO1/IRF8/ZBTB4/LRRFIP1/SPI1	12
GO:0001098	basal transcription machinery binding	3/683	70/18367	0.485474357461894	0.713503106730951	AHR/DRAP1/EDF1	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/683	70/18367	0.485474357461894	0.713503106730951	AHR/DRAP1/EDF1	3
GO:0022839	ion gated channel activity	2/683	44/18367	0.490755377831286	0.713503106730951	TTYH3/KCNMA1	2
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/683	18/18367	0.494616303476985	0.713503106730951	PTEN	1
GO:0004550	nucleoside diphosphate kinase activity	1/683	18/18367	0.494616303476985	0.713503106730951	CMPK1	1
GO:0005229	intracellular calcium activated chloride channel activity	1/683	18/18367	0.494616303476985	0.713503106730951	TTYH3	1
GO:0008409	5'-3' exonuclease activity	1/683	18/18367	0.494616303476985	0.713503106730951	PLD3	1
GO:0016755	aminoacyltransferase activity	1/683	18/18367	0.494616303476985	0.713503106730951	F13A1	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/683	18/18367	0.494616303476985	0.713503106730951	DAZAP2	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/683	18/18367	0.494616303476985	0.713503106730951	KCNAB2	1
GO:0050811	GABA receptor binding	1/683	18/18367	0.494616303476985	0.713503106730951	GABARAPL2	1
GO:0061778	intracellular chloride channel activity	1/683	18/18367	0.494616303476985	0.713503106730951	TTYH3	1
GO:0099095	ligand-gated anion channel activity	1/683	18/18367	0.494616303476985	0.713503106730951	GABRB2	1
GO:0140597	protein carrier activity	1/683	18/18367	0.494616303476985	0.713503106730951	TIMM10	1
GO:0001217	DNA-binding transcription repressor activity	12/683	313/18367	0.498633166774794	0.718065913112332	JUN/CEBPB/ATF3/MXI1/BHLHE40/SKIL/NFIL3/ENO1/IRF8/ZBTB4/LRRFIP1/SPI1	12
GO:0048156	tau protein binding	2/683	45/18367	0.502698915487829	0.71867838707708	APOE/PPP2CB	2
GO:0140223	general transcription initiation factor activity	2/683	45/18367	0.502698915487829	0.71867838707708	DRAP1/SNAPC2	2
GO:0008509	anion transmembrane transporter activity	12/683	314/18367	0.503108420315788	0.71867838707708	SLC6A8/SLC16A3/SLC1A3/CD36/CLIC2/SLC38A2/CLIC1/SLC2A3/SLC25A19/GABRB2/ABCC3/TTYH3	12
GO:0060090	molecular adaptor activity	14/683	369/18367	0.508029234009062	0.71867838707708	DAB2/KLF4/TRIM22/ARPC4/GRB2/ABI1/LAMTOR5/LRRK2/SERINC1/SDCBP/PSMC6/STX3/APH1A/CHCHD3	14
GO:0003713	transcription coactivator activity	10/683	262/18367	0.5119720112034	0.71867838707708	NUPR1/PAGE4/TRIM22/DRAP1/CITED2/EDF1/ARL2BP/ZBED1/HELZ2/XPC	10
GO:0005319	lipid transporter activity	6/683	154/18367	0.512283393413231	0.71867838707708	APOE/PLSCR1/TSPO/CD36/OSBPL1A/ABCC3	6
GO:0004129	cytochrome-c oxidase activity	1/683	19/18367	0.513428067863339	0.71867838707708	COX5B	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/683	19/18367	0.513428067863339	0.71867838707708	ACVRL1	1
GO:0004745	NAD-retinol dehydrogenase activity	1/683	19/18367	0.513428067863339	0.71867838707708	DHRS3	1
GO:0004890	GABA-A receptor activity	1/683	19/18367	0.513428067863339	0.71867838707708	GABRB2	1
GO:0004970	ionotropic glutamate receptor activity	1/683	19/18367	0.513428067863339	0.71867838707708	PTK2B	1
GO:0005003	ephrin receptor activity	1/683	19/18367	0.513428067863339	0.71867838707708	EPHB2	1
GO:0016918	retinal binding	1/683	19/18367	0.513428067863339	0.71867838707708	RBP1	1
GO:0035615	clathrin adaptor activity	1/683	19/18367	0.513428067863339	0.71867838707708	DAB2	1
GO:0052742	phosphatidylinositol kinase activity	1/683	19/18367	0.513428067863339	0.71867838707708	PIK3CB	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/683	19/18367	0.513428067863339	0.71867838707708	PTEN	1
GO:0015370	solute:sodium symporter activity	3/683	73/18367	0.513585862822027	0.71867838707708	SLC6A8/SLC1A3/SLC38A2	3
GO:0004519	endonuclease activity	5/683	129/18367	0.52645087378728	0.72805478755424	RNASE6/RNASET2/ANG/RPP30/RNASE1	5
GO:1901681	sulfur compound binding	10/683	265/18367	0.526546591266064	0.72805478755424	VEGFA/GPNMB/APOE/ANG/CHST15/SOAT1/FN1/ACBD5/AGRN/NRP1	10
GO:0003756	protein disulfide isomerase activity	1/683	20/18367	0.531540594005117	0.72805478755424	ERO1A	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/683	20/18367	0.531540594005117	0.72805478755424	IL4I1	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/683	20/18367	0.531540594005117	0.72805478755424	COX5B	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	1/683	20/18367	0.531540594005117	0.72805478755424	ERO1A	1
GO:0030296	protein tyrosine kinase activator activity	1/683	20/18367	0.531540594005117	0.72805478755424	ABI1	1
GO:0030506	ankyrin binding	1/683	20/18367	0.531540594005117	0.72805478755424	PLEC	1
GO:0031681	G-protein beta-subunit binding	1/683	20/18367	0.531540594005117	0.72805478755424	GNG5	1
GO:0031683	G-protein beta/gamma-subunit complex binding	1/683	20/18367	0.531540594005117	0.72805478755424	GNAQ	1
GO:0031690	adrenergic receptor binding	1/683	20/18367	0.531540594005117	0.72805478755424	ARRDC3	1
GO:0061608	nuclear import signal receptor activity	1/683	20/18367	0.531540594005117	0.72805478755424	KPNA3	1
GO:0140312	cargo adaptor activity	1/683	20/18367	0.531540594005117	0.72805478755424	DAB2	1
GO:0015078	proton transmembrane transporter activity	5/683	130/18367	0.533338095197556	0.729329004977471	SLC11A1/ATP6V1F/ATP6V1G1/ATP6V1B2/COX5B	5
GO:0008514	organic anion transmembrane transporter activity	7/683	185/18367	0.535364602976697	0.730165686546111	SLC6A8/SLC16A3/SLC1A3/CD36/SLC38A2/SLC2A3/SLC25A19	7
GO:0022853	active ion transmembrane transporter activity	10/683	267/18367	0.53618339270025	0.730165686546111	SLC11A1/SLC6A8/SLC1A3/ATP6V1F/SLC38A2/ATP6V1G1/ABCC3/ATP6V1B2/COX5B/ATP2C1	10
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/683	48/18367	0.53742278236866	0.730165686546111	GLUL/GATC	2
GO:0120013	lipid transfer activity	2/683	48/18367	0.53742278236866	0.730165686546111	APOE/TSPO	2
GO:0019212	phosphatase inhibitor activity	2/683	49/18367	0.548620186112565	0.733876118905406	LGALS3/ANP32E	2
GO:0001614	purinergic nucleotide receptor activity	1/683	21/18367	0.548979836077091	0.733876118905406	PTAFR	1
GO:0005123	death receptor binding	1/683	21/18367	0.548979836077091	0.733876118905406	MYD88	1
GO:0008373	sialyltransferase activity	1/683	21/18367	0.548979836077091	0.733876118905406	ST8SIA4	1
GO:0015125	bile acid transmembrane transporter activity	1/683	21/18367	0.548979836077091	0.733876118905406	ABCC3	1
GO:0015662	P-type ion transporter activity	1/683	21/18367	0.548979836077091	0.733876118905406	ATP2C1	1
GO:0016502	nucleotide receptor activity	1/683	21/18367	0.548979836077091	0.733876118905406	PTAFR	1
GO:0140358	P-type transmembrane transporter activity	1/683	21/18367	0.548979836077091	0.733876118905406	ATP2C1	1
GO:0140416	transcription regulator inhibitor activity	1/683	21/18367	0.548979836077091	0.733876118905406	SMAD7	1
GO:1990381	ubiquitin-specific protease binding	1/683	21/18367	0.548979836077091	0.733876118905406	PTEN	1
GO:0003724	RNA helicase activity	3/683	77/18367	0.549752621772183	0.733876118905406	IFIH1/DDX60/HELZ2	3
GO:0008237	metallopeptidase activity	7/683	190/18367	0.563776844654955	0.74229833266809	ADAM8/ADAM28/ANPEP/MMP19/MMP14/TFRC/CPD	7
GO:0005537	mannose binding	1/683	22/18367	0.565770786254751	0.74229833266809	CLEC4A	1
GO:0008093	cytoskeletal anchor activity	1/683	22/18367	0.565770786254751	0.74229833266809	SDCBP	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/683	22/18367	0.565770786254751	0.74229833266809	DHRS3	1
GO:0015645	fatty acid ligase activity	1/683	22/18367	0.565770786254751	0.74229833266809	ACSL1	1
GO:0016917	GABA receptor activity	1/683	22/18367	0.565770786254751	0.74229833266809	GABRB2	1
GO:0017075	syntaxin-1 binding	1/683	22/18367	0.565770786254751	0.74229833266809	LRRK2	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/683	22/18367	0.565770786254751	0.74229833266809	VCAN	1
GO:0055106	ubiquitin-protein transferase regulator activity	1/683	22/18367	0.565770786254751	0.74229833266809	TRIB1	1
GO:0070182	DNA polymerase binding	1/683	22/18367	0.565770786254751	0.74229833266809	PTGES3	1
GO:0072349	modified amino acid transmembrane transporter activity	1/683	22/18367	0.565770786254751	0.74229833266809	SLC6A8	1
GO:0008186	ATP-dependent activity, acting on RNA	3/683	79/18367	0.567230733036683	0.742994898775861	IFIH1/DDX60/HELZ2	3
GO:0046943	carboxylic acid transmembrane transporter activity	6/683	163/18367	0.568068632476669	0.742994898775861	SLC16A3/SLC1A3/CD36/SLC38A2/ABCC3/SLC16A10	6
GO:0005342	organic acid transmembrane transporter activity	6/683	164/18367	0.574076952169362	0.747189994167366	SLC16A3/SLC1A3/CD36/SLC38A2/ABCC3/SLC16A10	6
GO:0016830	carbon-carbon lyase activity	2/683	52/18367	0.581057721533098	0.747189994167366	ALDOA/UROD	2
GO:1901682	sulfur compound transmembrane transporter activity	2/683	52/18367	0.581057721533098	0.747189994167366	SLC25A19/ABCC3	2
GO:0004529	exodeoxyribonuclease activity	1/683	23/18367	0.5819375103206	0.747189994167366	PLD3	1
GO:0005212	structural constituent of eye lens	1/683	23/18367	0.5819375103206	0.747189994167366	VIM	1
GO:0005248	voltage-gated sodium channel activity	1/683	23/18367	0.5819375103206	0.747189994167366	SCN9A	1
GO:0015299	solute:proton antiporter activity	1/683	23/18367	0.5819375103206	0.747189994167366	SLC11A1	1
GO:0016493	C-C chemokine receptor activity	1/683	23/18367	0.5819375103206	0.747189994167366	CXCR4	1
GO:0016849	phosphorus-oxygen lyase activity	1/683	23/18367	0.5819375103206	0.747189994167366	RNASET2	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/683	23/18367	0.5819375103206	0.747189994167366	PLD3	1
GO:0050750	low-density lipoprotein particle receptor binding	1/683	23/18367	0.5819375103206	0.747189994167366	APOE	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/683	23/18367	0.5819375103206	0.747189994167366	GCNT1	1
GO:0008201	heparin binding	6/683	166/18367	0.585968100328323	0.751218250573353	VEGFA/GPNMB/APOE/ANG/FN1/NRP1	6
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/683	53/18367	0.591482350142733	0.757133419284686	SLC16A3/ABCC3	2
GO:0020037	heme binding	5/683	139/18367	0.593122750364162	0.758079381544469	HBG1/SDHD/HMOX1/CYCS/CYP1B1	5
GO:0004222	metalloendopeptidase activity	4/683	111/18367	0.595747160302192	0.760212066601631	ADAM8/ADAM28/MMP19/MMP14	4
GO:0016769	transferase activity, transferring nitrogenous groups	1/683	24/18367	0.597503181954433	0.760212066601631	GAPDH	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/683	24/18367	0.597503181954433	0.760212066601631	PYCARD	1
GO:0005544	calcium-dependent phospholipid binding	2/683	54/18367	0.601712361485995	0.764411021162722	ANXA1/ANXA2	2
GO:0015171	amino acid transmembrane transporter activity	3/683	84/18367	0.609051979206292	0.772446302776561	SLC1A3/SLC38A2/SLC16A10	3
GO:0004843	thiol-dependent deubiquitinase	4/683	113/18367	0.609874369849746	0.772446302776561	OTUD1/TNFAIP3/USP18/TANK	4
GO:0005227	calcium activated cation channel activity	1/683	25/18367	0.612490115756162	0.773429710737136	KCNMA1	1
GO:0070330	aromatase activity	1/683	25/18367	0.612490115756162	0.773429710737136	CYP1B1	1
GO:0003774	cytoskeletal motor activity	4/683	114/18367	0.616823141258719	0.774580106258779	MYO1G/KIF5B/DYNLRB1/MYL6	4
GO:0101005	deubiquitinase activity	4/683	114/18367	0.616823141258719	0.774580106258779	OTUD1/TNFAIP3/USP18/TANK	4
GO:0008013	beta-catenin binding	3/683	85/18367	0.617085221395222	0.774580106258779	KLF4/NR4A2/SMAD7	3
GO:0050660	flavin adenine dinucleotide binding	3/683	85/18367	0.617085221395222	0.774580106258779	ERO1A/KDM1B/KMO	3
GO:0022843	voltage-gated cation channel activity	5/683	143/18367	0.618289479332413	0.774935100027659	KCNQ3/KCNE1/KCNAB2/PTK2B/KCNMA1	5
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/683	56/18367	0.62158895133337	0.7753522808814	CARD16/CSTB	2
GO:0003730	mRNA 3'-UTR binding	7/683	201/18367	0.623297095146775	0.7753522808814	ZFP36L2/YBX3/ZFP36/HNRNPA0/ZNF385A/ELAVL1/CPEB2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	5/683	144/18367	0.624435687153333	0.7753522808814	LYZ/IL1RAP/MYD88/HEXB/TLR2	5
GO:0001637	G protein-coupled chemoattractant receptor activity	1/683	26/18367	0.626919799047981	0.7753522808814	CXCR4	1
GO:0004364	glutathione transferase activity	1/683	26/18367	0.626919799047981	0.7753522808814	ALOX5AP	1
GO:0004950	chemokine receptor activity	1/683	26/18367	0.626919799047981	0.7753522808814	CXCR4	1
GO:0042974	retinoic acid receptor binding	1/683	26/18367	0.626919799047981	0.7753522808814	NR4A2	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/683	26/18367	0.626919799047981	0.7753522808814	ABCC3	1
GO:0097602	cullin family protein binding	1/683	26/18367	0.626919799047981	0.7753522808814	RBX1	1
GO:0061659	ubiquitin-like protein ligase activity	11/683	316/18367	0.631402543973195	0.778791427490272	HERC5/TRIM22/SMURF2/DTX3L/RBX1/UBE2D2/RNF187/RNF5/UBE2D1/ZBED1/RNF145	11
GO:0001671	ATPase activator activity	1/683	27/18367	0.640812922500913	0.778791427490272	DNAJC15	1
GO:0004190	aspartic-type endopeptidase activity	1/683	27/18367	0.640812922500913	0.778791427490272	CTSD	1
GO:0008066	glutamate receptor activity	1/683	27/18367	0.640812922500913	0.778791427490272	PTK2B	1
GO:0015215	nucleotide transmembrane transporter activity	1/683	27/18367	0.640812922500913	0.778791427490272	SLC25A19	1
GO:0015491	cation:cation antiporter activity	1/683	27/18367	0.640812922500913	0.778791427490272	SLC11A1	1
GO:0016405	CoA-ligase activity	1/683	27/18367	0.640812922500913	0.778791427490272	ACSL1	1
GO:0016866	intramolecular transferase activity	1/683	27/18367	0.640812922500913	0.778791427490272	PGAM1	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/683	27/18367	0.640812922500913	0.778791427490272	PTEN	1
GO:0043425	bHLH transcription factor binding	1/683	27/18367	0.640812922500913	0.778791427490272	BHLHE40	1
GO:0048027	mRNA 5'-UTR binding	1/683	27/18367	0.640812922500913	0.778791427490272	NCL	1
GO:0051959	dynein light intermediate chain binding	1/683	27/18367	0.640812922500913	0.778791427490272	DYNLL1	1
GO:0008081	phosphoric diester hydrolase activity	3/683	89/18367	0.648088242384477	0.784840646930265	HMOX1/GPCPD1/PLD3	3
GO:0019842	vitamin binding	5/683	148/18367	0.648418509010674	0.784840646930265	EGLN3/P4HA1/EGLN1/RBP1/TCN2	5
GO:0036002	pre-mRNA binding	2/683	59/18367	0.649953397501728	0.784840646930265	SLU7/HNRNPA1	2
GO:0001968	fibronectin binding	1/683	28/18367	0.654189409629151	0.784840646930265	VEGFA	1
GO:0003785	actin monomer binding	1/683	28/18367	0.654189409629151	0.784840646930265	TMSB10	1
GO:0015101	organic cation transmembrane transporter activity	1/683	28/18367	0.654189409629151	0.784840646930265	SLC25A19	1
GO:0017056	structural constituent of nuclear pore	1/683	28/18367	0.654189409629151	0.784840646930265	NUP58	1
GO:0070001	aspartic-type peptidase activity	1/683	28/18367	0.654189409629151	0.784840646930265	CTSD	1
GO:0070325	lipoprotein particle receptor binding	1/683	28/18367	0.654189409629151	0.784840646930265	APOE	1
GO:0022824	transmitter-gated ion channel activity	2/683	60/18367	0.659025146091765	0.78839281346113	GABRB2/PTK2B	2
GO:0022835	transmitter-gated channel activity	2/683	60/18367	0.659025146091765	0.78839281346113	GABRB2/PTK2B	2
GO:0005267	potassium channel activity	4/683	121/18367	0.663253150611987	0.791987445829086	KCNQ3/KCNE1/KCNAB2/KCNMA1	4
GO:0004181	metallocarboxypeptidase activity	1/683	29/18367	0.667068445193974	0.791987445829086	CPD	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/683	29/18367	0.667068445193974	0.791987445829086	IL4I1	1
GO:0033612	receptor serine/threonine kinase binding	1/683	29/18367	0.667068445193974	0.791987445829086	PYCARD	1
GO:0051059	NF-kappaB binding	1/683	29/18367	0.667068445193974	0.791987445829086	NFKBIA	1
GO:0015179	L-amino acid transmembrane transporter activity	2/683	61/18367	0.667907474550805	0.791987445829086	SLC1A3/SLC38A2	2
GO:0015399	primary active transmembrane transporter activity	6/683	181/18367	0.669271782329806	0.791987445829086	ATP6V1F/ATP6V1G1/ABCC3/ATP6V1B2/COX5B/ATP2C1	6
GO:0005179	hormone activity	4/683	122/18367	0.669563702716385	0.791987445829086	ADM/HAMP/CGA/IGF2	4
GO:0015103	inorganic anion transmembrane transporter activity	5/683	152/18367	0.671413134829656	0.793059615718737	CLIC2/CLIC1/GABRB2/ABCC3/TTYH3	5
GO:0046966	thyroid hormone receptor binding	1/683	30/18367	0.67946850255751	0.801448822792238	OASL	1
GO:0140098	catalytic activity, acting on RNA	13/683	386/18367	0.681964838350913	0.803266707357308	RNASE6/NT5C3A/IFIH1/RNASET2/ANG/N4BP1/DDX60/SLU7/GATC/RPP30/RNASE1/POLR2E/HELZ2	13
GO:0019783	ubiquitin-like protein-specific protease activity	4/683	125/18367	0.688004458124157	0.809247201793588	OTUD1/TNFAIP3/USP18/TANK	4
GO:0016878	acid-thiol ligase activity	1/683	31/18367	0.691407370025101	0.809851808065612	ACSL1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/683	31/18367	0.691407370025101	0.809851808065612	ABCC3	1
GO:0140142	nucleocytoplasmic carrier activity	1/683	31/18367	0.691407370025101	0.809851808065612	KPNA3	1
GO:0004386	helicase activity	5/683	156/18367	0.693395169683252	0.810615618034737	IFIH1/ANXA1/DDX60/ZNFX1/HELZ2	5
GO:0008242	omega peptidase activity	4/683	126/18367	0.693987211634971	0.810615618034737	OTUD1/TNFAIP3/USP18/TANK	4
GO:0061630	ubiquitin protein ligase activity	10/683	304/18367	0.698057249234605	0.814238760896398	HERC5/TRIM22/SMURF2/DTX3L/RBX1/UBE2D2/RNF187/RNF5/UBE2D1/RNF145	10
GO:0001223	transcription coactivator binding	1/683	32/18367	0.702902176213629	0.816492721264727	AHR	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/683	32/18367	0.702902176213629	0.816492721264727	SLC25A19	1
GO:0030515	snoRNA binding	1/683	32/18367	0.702902176213629	0.816492721264727	NOP10	1
GO:0002039	p53 binding	2/683	66/18367	0.709535985815943	0.823061743546493	PLK3/ZNF385A	2
GO:0004867	serine-type endopeptidase inhibitor activity	3/683	98/18367	0.711169563959507	0.823820390206536	SERPING1/ANXA2/SERPINB1	3
GO:0016831	carboxy-lyase activity	1/683	34/18367	0.724624966456718	0.835153236631227	UROD	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/683	34/18367	0.724624966456718	0.835153236631227	RPP30	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/683	34/18367	0.724624966456718	0.835153236631227	PTEN	1
GO:0003684	damaged DNA binding	2/683	68/18367	0.724924925970031	0.835153236631227	RPA2/XPC	2
GO:0003777	microtubule motor activity	2/683	69/18367	0.732357584117835	0.842561871741585	KIF5B/DYNLRB1	2
GO:0015298	solute:cation antiporter activity	1/683	35/18367	0.734884124691052	0.844313591345868	SLC11A1	1
GO:0004497	monooxygenase activity	3/683	102/18367	0.736266621183136	0.844747924167827	HMOX1/CYP1B1/KMO	3
GO:0000217	DNA secondary structure binding	1/683	36/18367	0.744761614481365	0.85101157306906	XPC	1
GO:0005484	SNAP receptor activity	1/683	36/18367	0.744761614481365	0.85101157306906	STX3	1
GO:0034061	DNA polymerase activity	1/683	36/18367	0.744761614481365	0.85101157306906	PTGES3	1
GO:0004620	phospholipase activity	3/683	104/18367	0.748153592087957	0.852570692338715	HMOX1/PLBD1/PLD3	3
GO:0015294	solute:cation symporter activity	3/683	104/18367	0.748153592087957	0.852570692338715	SLC6A8/SLC1A3/SLC38A2	3
GO:0000049	tRNA binding	2/683	72/18367	0.753637080971627	0.854908932768416	IFIT5/SSB	2
GO:0030276	clathrin binding	2/683	72/18367	0.753637080971627	0.854908932768416	DAB2/LRRK2	2
GO:0005109	frizzled binding	1/683	37/18367	0.754271614880101	0.854908932768416	SDCBP	1
GO:0043531	ADP binding	1/683	37/18367	0.754271614880101	0.854908932768416	PGK1	1
GO:0005230	extracellular ligand-gated ion channel activity	2/683	73/18367	0.760399087116686	0.854917126604838	GABRB2/PTK2B	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/683	38/18367	0.763427778930122	0.854917126604838	FKBP5	1
GO:0005501	retinoid binding	1/683	38/18367	0.763427778930122	0.854917126604838	RBP1	1
GO:0008395	steroid hydroxylase activity	1/683	38/18367	0.763427778930122	0.854917126604838	CYP1B1	1
GO:0015175	neutral amino acid transmembrane transporter activity	1/683	38/18367	0.763427778930122	0.854917126604838	SLC38A2	1
GO:0019213	deacetylase activity	1/683	38/18367	0.763427778930122	0.854917126604838	ESD	1
GO:0019840	isoprenoid binding	1/683	38/18367	0.763427778930122	0.854917126604838	RBP1	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/683	38/18367	0.763427778930122	0.854917126604838	RNF5	1
GO:0140303	intramembrane lipid transporter activity	1/683	38/18367	0.763427778930122	0.854917126604838	PLSCR1	1
GO:0090079	translation regulator activity, nucleic acid binding	3/683	108/18367	0.770637958577908	0.861843780803219	RPS27L/EIF4E/CPEB2	3
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	1/683	39/18367	0.772243253150796	0.862492132669083	POLR2E	1
GO:0043014	alpha-tubulin binding	1/683	40/18367	0.780730696303241	0.869089989338506	SETD2	1
GO:0044183	protein folding chaperone	1/683	40/18367	0.780730696303241	0.869089989338506	CD74	1
GO:0000149	SNARE binding	3/683	110/18367	0.781250929773972	0.869089989338506	GABARAPL2/LRRK2/STX3	3
GO:0008194	UDP-glycosyltransferase activity	4/683	143/18367	0.783250438579023	0.870163300984092	B3GNT7/GCNT1/HEXB/B3GNT5	4
GO:0030594	neurotransmitter receptor activity	3/683	111/18367	0.786403812259299	0.871749619004607	TSPO/GABRB2/PTK2B	3
GO:0106310	protein serine kinase activity	11/683	360/18367	0.787691751768292	0.871749619004607	EIF2AK2/SGK1/PRKX/MAP3K2/LRRK2/WNK1/PLK3/MAP3K3/CAMK1/FAM20C/RIPK2	11
GO:0015293	symporter activity	4/683	144/18367	0.787788002905471	0.871749619004607	SLC6A8/SLC16A3/SLC1A3/SLC38A2	4
GO:0016859	cis-trans isomerase activity	1/683	41/18367	0.788902297461362	0.871835521898824	FKBP5	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/683	43/18367	0.804344485425125	0.883098841047689	KMO	1
GO:0018024	histone-lysine N-methyltransferase activity	1/683	43/18367	0.804344485425125	0.883098841047689	SETD2	1
GO:0030547	signaling receptor inhibitor activity	1/683	43/18367	0.804344485425125	0.883098841047689	LY6E	1
GO:0034062	5'-3' RNA polymerase activity	1/683	43/18367	0.804344485425125	0.883098841047689	POLR2E	1
GO:0097747	RNA polymerase activity	1/683	43/18367	0.804344485425125	0.883098841047689	POLR2E	1
GO:0042393	histone binding	7/683	244/18367	0.80680035625529	0.884640286324249	STAT1/PHC2/DTX3L/PARP9/ANP32E/KDM1B/RSF1	7
GO:0035591	signaling adaptor activity	2/683	81/18367	0.808911769485436	0.88580051840788	ABI1/LRRK2	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/683	44/18367	0.811637255369168	0.88647653476035	SGK1	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/683	44/18367	0.811637255369168	0.88647653476035	GABRB2	1
GO:0046873	metal ion transmembrane transporter activity	13/683	430/18367	0.814338253649408	0.888272984849743	SLC11A1/SLC6A8/SLC25A37/SLC1A3/KCNQ3/SLC38A2/KCNE1/KCNAB2/ANXA2/KCNMA1/SCN9A/ORAI3/ATP2C1	13
GO:0022836	gated channel activity	10/683	340/18367	0.816856091740701	0.889865250199391	KCNQ3/CLIC2/CLIC1/KCNE1/GABRB2/KCNAB2/PTK2B/TTYH3/KCNMA1/SCN9A	10
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/683	45/18367	0.818658581275562	0.890675118826323	RPP30	1
GO:0015081	sodium ion transmembrane transporter activity	4/683	152/18367	0.821402851957934	0.892506199608039	SLC6A8/SLC1A3/SLC38A2/SCN9A	4
GO:0008135	translation factor activity, RNA binding	2/683	84/18367	0.824722708927604	0.893406695596843	EIF4E/CPEB2	2
GO:0004864	protein phosphatase inhibitor activity	1/683	46/18367	0.825418552293398	0.893406695596843	LGALS3	1
GO:0005272	sodium channel activity	1/683	46/18367	0.825418552293398	0.893406695596843	SCN9A	1
GO:0022804	active transmembrane transporter activity	12/683	406/18367	0.829565356625895	0.896740957483776	SLC11A1/SLC6A8/SLC16A3/SLC1A3/ATP6V1F/SLC38A2/ATP6V1G1/ABCC3/ATP6V1B2/COX5B/SLC16A10/ATP2C1	12
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/683	47/18367	0.83192688310414	0.897954478417926	GABRB2	1
GO:0015079	potassium ion transmembrane transporter activity	4/683	155/18367	0.832823416368588	0.897954478417926	KCNQ3/KCNE1/KCNAB2/KCNMA1	4
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/683	88/18367	0.843972416287226	0.9083754044084	NCF1/KMO	2
GO:0140101	catalytic activity, acting on a tRNA	3/683	124/18367	0.844648711352401	0.9083754044084	NT5C3A/GATC/RPP30	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/683	50/18367	0.850033851976602	0.910673209569837	SLC25A19	1
GO:0030159	signaling receptor complex adaptor activity	1/683	50/18367	0.850033851976602	0.910673209569837	LRRK2	1
GO:0140359	ABC-type transporter activity	1/683	50/18367	0.850033851976602	0.910673209569837	ABCC3	1
GO:0003743	translation initiation factor activity	1/683	51/18367	0.855625754531604	0.914334510242794	EIF4E	1
GO:0051018	protein kinase A binding	1/683	51/18367	0.855625754531604	0.914334510242794	LRRK2	1
GO:0008146	sulfotransferase activity	1/683	52/18367	0.861009441453143	0.916626023760677	CHST15	1
GO:0017046	peptide hormone binding	1/683	52/18367	0.861009441453143	0.916626023760677	EBI3	1
GO:0016758	hexosyltransferase activity	5/683	197/18367	0.861039903413715	0.916626023760677	TYMP/B3GNT7/GCNT1/HEXB/B3GNT5	5
GO:0016298	lipase activity	3/683	129/18367	0.863088541027277	0.917645338816612	HMOX1/PLBD1/PLD3	3
GO:0017069	snRNA binding	1/683	53/18367	0.866192654747574	0.917868161752484	LARP7	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/683	53/18367	0.866192654747574	0.917868161752484	ABCC3	1
GO:0016874	ligase activity	4/683	165/18367	0.866572319181299	0.917868161752484	GLUL/ACSL1/UBA6/GATC	4
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	2/683	94/18367	0.869264267587705	0.919561319548755	LYZ/HEXB	2
GO:0030374	nuclear receptor coactivator activity	1/683	56/18367	0.88061262456925	0.928954688274577	HELZ2	1
GO:0042054	histone methyltransferase activity	1/683	56/18367	0.88061262456925	0.928954688274577	SETD2	1
GO:0015085	calcium ion transmembrane transporter activity	3/683	135/18367	0.882655694500338	0.928954688274577	ANXA2/ORAI3/ATP2C1	3
GO:0005216	ion channel activity	12/683	432/18367	0.883677872004585	0.928954688274577	KCNQ3/CLIC2/CLIC1/KCNE1/GABRB2/KCNAB2/PTK2B/TTYH3/ANXA2/KCNMA1/SCN9A/ORAI3	12
GO:0004536	deoxyribonuclease activity	1/683	57/18367	0.885065771716823	0.928954688274577	PLD3	1
GO:0005548	phospholipid transporter activity	1/683	57/18367	0.885065771716823	0.928954688274577	PLSCR1	1
GO:0015291	secondary active transmembrane transporter activity	6/683	240/18367	0.885875933408098	0.928954688274577	SLC11A1/SLC6A8/SLC16A3/SLC1A3/SLC38A2/SLC16A10	6
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/683	58/18367	0.889353050685551	0.931439496421604	ALOX5AP	1
GO:0016279	protein-lysine N-methyltransferase activity	1/683	59/18367	0.893480630912858	0.933437528692812	SETD2	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/683	59/18367	0.893480630912858	0.933437528692812	PLD3	1
GO:0016278	lysine N-methyltransferase activity	1/683	60/18367	0.897454452689487	0.935265420956454	SETD2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/683	60/18367	0.897454452689487	0.935265420956454	SDHB	1
GO:0098960	postsynaptic neurotransmitter receptor activity	1/683	62/18367	0.904963486999297	0.941923629413872	GABRB2	1
GO:0016746	acyltransferase activity	6/683	250/18367	0.906966237767204	0.942841292907563	GLUL/ZDHHC20/F13A1/SOAT1/AGPAT2/ABHD5	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	5/683	222/18367	0.919349551803434	0.954534534650232	GLUL/ZDHHC20/SOAT1/AGPAT2/ABHD5	5
GO:0016782	transferase activity, transferring sulphur-containing groups	1/683	68/18367	0.924353388501803	0.958546485487073	CHST15	1
GO:0001653	peptide receptor activity	3/683	153/18367	0.927240208957718	0.960355930706208	CXCR4/FPR3/OGFR	3
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/683	71/18367	0.932512000980055	0.963678160353617	HINT3	1
GO:0005261	cation channel activity	8/683	335/18367	0.934061966179017	0.963678160353617	KCNQ3/KCNE1/KCNAB2/PTK2B/ANXA2/KCNMA1/SCN9A/ORAI3	8
GO:0003678	DNA helicase activity	1/683	72/18367	0.935031366050596	0.963678160353617	ANXA1	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	1/683	72/18367	0.935031366050596	0.963678160353617	COX5B	1
GO:0070063	RNA polymerase binding	1/683	73/18367	0.937456814369123	0.963986919252386	ZFP36	1
GO:0005262	calcium channel activity	2/683	119/18367	0.93899516459314	0.963986919252386	ANXA2/ORAI3	2
GO:0019905	syntaxin binding	1/683	74/18367	0.939791842016761	0.963986919252386	LRRK2	1
GO:0140030	modification-dependent protein binding	3/683	160/18367	0.939915902243705	0.963986919252386	TNFAIP3/TAB2/SQSTM1	3
GO:0051082	unfolded protein binding	2/683	122/18367	0.944456632729197	0.967464102466814	PTGES3/PFDN6	2
GO:0015267	channel activity	12/683	480/18367	0.94688448800047	0.968527006233879	KCNQ3/CLIC2/CLIC1/KCNE1/GABRB2/KCNAB2/PTK2B/TTYH3/ANXA2/KCNMA1/SCN9A/ORAI3	12
GO:0022803	passive transmembrane transporter activity	12/683	481/18367	0.94779753404338	0.968527006233879	KCNQ3/CLIC2/CLIC1/KCNE1/GABRB2/KCNAB2/PTK2B/TTYH3/ANXA2/KCNMA1/SCN9A/ORAI3	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/683	125/18367	0.949450928345914	0.968652791680603	DDAH2/HINT3	2
GO:0034987	immunoglobulin receptor binding	1/683	79/18367	0.950224201113552	0.968652791680603	FLNA	1
GO:0004527	exonuclease activity	1/683	80/18367	0.95208317260521	0.96937281859683	PLD3	1
GO:0008276	protein methyltransferase activity	1/683	88/18367	0.964664323617538	0.980994795843228	SETD2	1
GO:0015297	antiporter activity	1/683	89/18367	0.965984651150183	0.981151076832493	SLC11A1	1
GO:0015276	ligand-gated ion channel activity	2/683	143/18367	0.971513467865981	0.983780662032598	GABRB2/PTK2B	2
GO:0022834	ligand-gated channel activity	2/683	143/18367	0.971513467865981	0.983780662032598	GABRB2/PTK2B	2
GO:0008170	N-methyltransferase activity	1/683	97/18367	0.974919633286813	0.983780662032598	SETD2	1
GO:0008528	G protein-coupled peptide receptor activity	2/683	147/18367	0.974965488716516	0.983780662032598	CXCR4/FPR3	2
GO:0052689	carboxylic ester hydrolase activity	2/683	147/18367	0.974965488716516	0.983780662032598	ESD/ABHD5	2
GO:0016887	ATP hydrolysis activity	5/683	272/18367	0.975592237972874	0.983780662032598	IFIH1/OLA1/DDX60/KIF5B/ATP2C1	5
GO:0031490	chromatin DNA binding	1/683	103/18367	0.980045569868622	0.987087813484445	PER1	1
GO:0008094	ATP-dependent activity, acting on DNA	1/683	111/18367	0.985290603316102	0.991084508565194	ANXA1	1
GO:0099094	ligand-gated cation channel activity	1/683	113/18367	0.986370670236703	0.991084508565194	PTK2B	1
GO:0140097	catalytic activity, acting on DNA	3/683	229/18367	0.991965904101636	0.995517094689112	ANXA1/PTGES3/PLD3	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/683	156/18367	0.997360688342601	0.999347084240241	SETD2	1
GO:0016741	transferase activity, transferring one-carbon groups	2/683	225/18367	0.998158799954581	0.999347084240241	GATM/SETD2	2
GO:0008168	methyltransferase activity	1/683	214/18367	0.999713537109534	0.999713537109534	SETD2	1