ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	23/271	332/18367	8.95274697715353e-10	4.8165778737086e-07	ENO1/RAB1A/HDLBP/EIF4H/PUF60/KRT18/NUDC/CNN3/LDHA/ARGLU1/EIF3E/PCBP1/EPS8L1/PKM/PLIN3/WASF2/CTTN/ERC1/ALDOA/IST1/GLOD4/RSL1D1/EIF2A	23
GO:0008135	translation factor activity, RNA binding	8/271	84/18367	3.35127413859859e-05	0.0090149274328302	EIF4H/EIF5A/GSPT1/EIF3E/EIF4B/EIF4E2/EIF6/EIF2A	8
GO:0043021	ribonucleoprotein complex binding	10/271	149/18367	7.48061720776587e-05	0.010838694686067	EIF4H/EIF5A/YBX3/SNRPD1/SNRPD2/NPM1/EIF4B/EIF6/TIMM50/EIF2A	10
GO:0051082	unfolded protein binding	9/271	122/18367	8.28068909903582e-05	0.010838694686067	NUDC/CALR/NPM1/ST13/DNAJA2/TOMM20/CCT6A/CCT5/CLPX	9
GO:0003743	translation initiation factor activity	6/271	51/18367	0.000100731363253411	0.010838694686067	EIF4H/EIF3E/EIF4B/EIF4E2/EIF6/EIF2A	6
GO:0042162	telomeric DNA binding	5/271	36/18367	0.000174727690313141	0.0153453848103516	NCL/HNRNPD/XRCC6/HNRNPA1/APEX1	5
GO:0090079	translation regulator activity, nucleic acid binding	8/271	108/18367	0.000199661140655132	0.0153453848103516	EIF4H/EIF5A/GSPT1/EIF3E/EIF4B/EIF4E2/EIF6/EIF2A	8
GO:0045182	translation regulator activity	9/271	140/18367	0.000236263927223565	0.0158887491057847	EIF2AK1/EIF4H/EIF5A/GSPT1/EIF3E/EIF4B/EIF4E2/EIF6/EIF2A	9
GO:0043024	ribosomal small subunit binding	3/271	17/18367	0.00185328323381667	0.110785153310375	EIF4H/NPM1/EIF4B	3
GO:0015175	neutral amino acid transmembrane transporter activity	4/271	38/18367	0.00230624417864862	0.114405653125373	SERINC3/SLC43A2/SLC38A2/SLC38A1	4
GO:0003697	single-stranded DNA binding	7/271	123/18367	0.00233914904159685	0.114405653125373	RAD23A/PCBP1/TOP1/YBX1/HNRNPA1/FUBP1/NABP1	7
GO:0009055	electron transfer activity	7/271	126/18367	0.00267922064608146	0.120118392299319	COX7A2L/NDUFV2/NDUFB8/CYCS/NDUFB5/STEAP4/DEGS1	7
GO:0097110	scaffold protein binding	5/271	67/18367	0.00308919140939738	0.127844998327369	DSP/KRT18/CRK/XRCC6/MAP2K2	5
GO:0015399	primary active transmembrane transporter activity	8/271	181/18367	0.00553403121772784	0.212664913938399	ATP1B3/COX7A2L/NDUFV2/ATP6V1B2/NDUFB8/TOMM20/ATP6V1D/NDUFB5	8
GO:0048027	mRNA 5'-UTR binding	3/271	27/18367	0.00715146054418512	0.256499051518106	NCL/RSL1D1/CCT5	3
GO:0051059	NF-kappaB binding	3/271	29/18367	0.00874272794603186	0.264046505741223	NPM1/NFKBIA/APEX1	3
GO:0045503	dynein light chain binding	2/271	10/18367	0.0090269841535731	0.264046505741223	DYNC1I2/HOOK3	2
GO:0016853	isomerase activity	7/271	158/18367	0.00911424813050426	0.264046505741223	TOP1/ERP44/PPIG/HSD17B4/PDIA6/DEGS1/PGM2	7
GO:0003727	single-stranded RNA binding	5/271	87/18367	0.00932506247041494	0.264046505741223	HNRNPF/EIF4H/EIF4B/HNRNPC/HNRNPA1	5
GO:0022889	serine transmembrane transporter activity	2/271	11/18367	0.0109262794124139	0.293916916193933	SERINC3/SLC38A2	2
GO:0051427	hormone receptor binding	3/271	33/18367	0.0125030170615564	0.306419856097505	CSH1/CSH2/CSHL1	3
GO:0015179	L-amino acid transmembrane transporter activity	4/271	61/18367	0.0125301799891173	0.306419856097505	SERINC3/SLC43A2/SLC38A2/SLC38A1	4
GO:0043023	ribosomal large subunit binding	2/271	14/18367	0.0175598398919953	0.318968997379578	NPM1/EIF6	2
GO:0140666	annealing activity	2/271	14/18367	0.0175598398919953	0.318968997379578	EIF4H/EIF4B	2
GO:0004860	protein kinase inhibitor activity	4/271	70/18367	0.0198774413699333	0.318968997379578	SH3BP5/NPM1/YWHAG/HEXIM1	4
GO:0048185	activin binding	2/271	15/18367	0.0200663667729524	0.318968997379578	FSTL3/ENG	2
GO:0098847	sequence-specific single stranded DNA binding	2/271	15/18367	0.0200663667729524	0.318968997379578	PCBP1/HNRNPA1	2
GO:1990825	sequence-specific mRNA binding	2/271	15/18367	0.0200663667729524	0.318968997379578	SRSF3/SRSF4	2
GO:0048029	monosaccharide binding	4/271	71/18367	0.0208270624653324	0.318968997379578	UGP2/ENG/ALDOA/PAM	4
GO:0044183	protein folding chaperone	3/271	40/18367	0.0210012602130578	0.318968997379578	CALR/CCT6A/CCT5	3
GO:0051087	chaperone binding	5/271	107/18367	0.0212074956775022	0.318968997379578	CALR/GAK/ST13/DNAJA2/BAG1	5
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	4/271	72/18367	0.0218041090632351	0.318968997379578	COX7A2L/NDUFV2/NDUFB8/NDUFB5	4
GO:0005159	insulin-like growth factor receptor binding	2/271	16/18367	0.0227125668127503	0.318968997379578	CRK/YWHAG	2
GO:0005283	amino acid:sodium symporter activity	2/271	16/18367	0.0227125668127503	0.318968997379578	SLC38A2/SLC38A1	2
GO:0047485	protein N-terminus binding	5/271	110/18367	0.023573719234655	0.318968997379578	EIF5A/EIF3E/NPM1/VPS25/SRRM2	5
GO:0019210	kinase inhibitor activity	4/271	74/18367	0.0238411697177955	0.318968997379578	SH3BP5/NPM1/YWHAG/HEXIM1	4
GO:0008137	NADH dehydrogenase (ubiquinone) activity	3/271	42/18367	0.023885486538067	0.318968997379578	NDUFV2/NDUFB8/NDUFB5	3
GO:0019003	GDP binding	4/271	75/18367	0.0249015001486379	0.318968997379578	RAB14/ARF1/RHOB/RAB9A	4
GO:0050136	NADH dehydrogenase (quinone) activity	3/271	43/18367	0.0254038764254368	0.318968997379578	NDUFV2/NDUFB8/NDUFB5	3
GO:0042625	ATPase-coupled ion transmembrane transporter activity	2/271	17/18367	0.0254938046232748	0.318968997379578	ATP6V1B2/ATP6V1D	2
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	2/271	17/18367	0.0254938046232748	0.318968997379578	ATP6V1B2/ATP6V1D	2
GO:0046961	proton-transporting ATPase activity, rotational mechanism	2/271	17/18367	0.0254938046232748	0.318968997379578	ATP6V1B2/ATP6V1D	2
GO:0070628	proteasome binding	2/271	17/18367	0.0254938046232748	0.318968997379578	RAD23A/PSMD14	2
GO:0098641	cadherin binding involved in cell-cell adhesion	2/271	18/18367	0.0284055503129396	0.334412477686174	KRT18/CNN3	2
GO:0003954	NADH dehydrogenase activity	3/271	45/18367	0.0285928884266989	0.334412477686174	NDUFV2/NDUFB8/NDUFB5	3
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	3/271	45/18367	0.0285928884266989	0.334412477686174	NDUFV2/NDUFB8/NDUFB5	3
GO:0003730	mRNA 3'-UTR binding	7/271	201/18367	0.0299218414203526	0.342509589024462	YBX3/HNRNPD/HNRNPC/LARP4B/ZFP36L1/RSL1D1/CCT5	7
GO:0019829	ATPase-coupled cation transmembrane transporter activity	3/271	47/18367	0.0319840516282148	0.34940920541165	ATP1B3/ATP6V1B2/ATP6V1D	3
GO:0031625	ubiquitin protein ligase binding	9/271	297/18367	0.0327028641810169	0.34940920541165	RRAGA/CALR/CRK/UBC/UBE2J1/EIF4E2/TOLLIP/NFKBIA/BAG1	9
GO:0003756	protein disulfide isomerase activity	2/271	20/18367	0.0346029607736186	0.34940920541165	ERP44/PDIA6	2
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	2/271	20/18367	0.0346029607736186	0.34940920541165	ATP6V1B2/ATP6V1D	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/271	20/18367	0.0346029607736186	0.34940920541165	ERP44/PDIA6	2
GO:0005179	hormone activity	5/271	122/18367	0.0347113147616367	0.34940920541165	CSH1/INHBA/CSH2/INHA/CSHL1	5
GO:0098632	cell-cell adhesion mediator activity	3/271	49/18367	0.0355759340488443	0.34940920541165	DSP/KRT18/CNN3	3
GO:0015171	amino acid transmembrane transporter activity	4/271	84/18367	0.0357202719287003	0.34940920541165	SERINC3/SLC43A2/SLC38A2/SLC38A1	4
GO:0005048	signal sequence binding	3/271	50/18367	0.0374465684829368	0.359754532925357	KDELR2/TOMM20/NFKBIA	3
GO:0022804	active transmembrane transporter activity	11/271	406/18367	0.0392084845536176	0.370073064734145	ATP1B3/COX7A2L/NDUFV2/SLC16A3/ATP6V1B2/NDUFB8/TOMM20/SLC38A2/ATP6V1D/SLC38A1/NDUFB5	11
GO:0005416	amino acid:cation symporter activity	2/271	22/18367	0.0412705907087838	0.370644630195404	SLC38A2/SLC38A1	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/271	22/18367	0.0412705907087838	0.370644630195404	TNFAIP8/SERPINB9	2
GO:0031593	polyubiquitin modification-dependent protein binding	3/271	52/18367	0.0413358323637997	0.370644630195404	PSMD4/RAD23A/ZFAND6	3
GO:0017069	snRNA binding	3/271	53/18367	0.0433538291445369	0.379038153262754	EIF5A/SNU13/HEXIM1	3
GO:0017124	SH3 domain binding	5/271	130/18367	0.0436809767700571	0.379038153262754	SH3BP5/ERRFI1/WASF2/PTPN12/CRK	5
GO:0070412	R-SMAD binding	2/271	23/18367	0.0447704759629356	0.382325651873958	FOS/TRIM33	2
GO:0044389	ubiquitin-like protein ligase binding	9/271	316/18367	0.0454827612924269	0.382339462114463	RRAGA/CALR/CRK/UBC/UBE2J1/EIF4E2/TOLLIP/NFKBIA/BAG1	9
GO:0005080	protein kinase C binding	3/271	55/18367	0.0475347939961504	0.393441833383522	DSP/HINT1/YWHAG	3
GO:0005126	cytokine receptor binding	8/271	271/18367	0.0484127169459483	0.394636995710912	CSH1/GATA3/CSH2/ENG/CNIH4/CSHL1/TOLLIP/TIMM50	8
GO:0042277	peptide binding	9/271	321/18367	0.0493323092626964	0.394654736328287	INHBA/CALR/FURIN/SCARB1/PPIG/KDELR2/TOMM20/NFKBIA/RPS6KB2	9
GO:0002020	protease binding	5/271	135/18367	0.0499312111745177	0.394654736328287	RAD23A/SERPINB9/FURIN/SRI/UBC	5
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	3/271	57/18367	0.0519064544874559	0.394654736328287	NDUFV2/NDUFB8/NDUFB5	3
GO:0034237	protein kinase A regulatory subunit binding	2/271	25/18367	0.0520826882515025	0.394654736328287	WASF2/AKAP9	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/271	25/18367	0.0520826882515025	0.394654736328287	HNRNPD/ZFP36L1	2
GO:0061134	peptidase regulator activity	7/271	230/18367	0.0548566816202387	0.409901315440117	GAPDH/TNFAIP8/SERPINB9/SPINT2/FURIN/PSMD14/CLPX	7
GO:0098631	cell adhesion mediator activity	3/271	59/18367	0.0564654111792307	0.416142345403098	DSP/KRT18/CNN3	3
GO:0001671	ATPase activator activity	2/271	27/18367	0.0597862856586062	0.43466245519365	ATP1B3/DNAJA2	2
GO:0003779	actin binding	11/271	440/18367	0.0626129864073439	0.449143822495347	LIMCH1/CNN3/ARPC5L/PDLIM2/TPM4/EPS8L1/CAP1/ACTR3/WASF2/CTTN/ALDOA	11
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/271	28/18367	0.063775732536564	0.451465054008834	PDCD6/HERPUD1	2
GO:0005200	structural constituent of cytoskeleton	4/271	103/18367	0.0661992732475023	0.46253518191112	KRT19/DSP/ACTR3/TUBA1C	4
GO:0070273	phosphatidylinositol-4-phosphate binding	2/271	29/18367	0.067852251395122	0.464434627899385	GOLPH3/OSBP	2
GO:0061135	endopeptidase regulator activity	6/271	194/18367	0.0681976498216569	0.464434627899385	GAPDH/TNFAIP8/SERPINB9/SPINT2/FURIN/PSMD14	6
GO:0005343	organic acid:sodium symporter activity	2/271	30/18367	0.0720124261267549	0.484283565702427	SLC38A2/SLC38A1	2
GO:0043022	ribosome binding	3/271	66/18367	0.0738411184807015	0.490450885711326	EIF5A/EIF6/EIF2A	3
GO:0042626	ATPase-coupled transmembrane transporter activity	4/271	109/18367	0.0779384645342862	0.507260569260021	ATP1B3/ATP6V1B2/TOMM20/ATP6V1D	4
GO:0003684	damaged DNA binding	3/271	68/18367	0.0791936697523437	0.507260569260021	RAD23A/XRCC6/APEX1	3
GO:0030332	cyclin binding	2/271	32/18367	0.080570483077399	0.507260569260021	GAK/XRCC6	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/271	34/18367	0.0894241690097049	0.507260569260021	YWHAG/HEXIM1	2
GO:0035198	miRNA binding	2/271	34/18367	0.0894241690097049	0.507260569260021	YBX1/HNRNPA1	2
GO:0008083	growth factor activity	5/271	162/18367	0.0922636297292399	0.507260569260021	CSH1/INHBA/CSH2/INHA/CSHL1	5
GO:0046943	carboxylic acid transmembrane transporter activity	5/271	163/18367	0.0941034605508155	0.507260569260021	SERINC3/SLC16A3/SLC43A2/SLC38A2/SLC38A1	5
GO:0005342	organic acid transmembrane transporter activity	5/271	164/18367	0.0959620161727813	0.507260569260021	SERINC3/SLC16A3/SLC43A2/SLC38A2/SLC38A1	5
GO:0003725	double-stranded RNA binding	3/271	74/18367	0.0962166345364581	0.507260569260021	EIF4H/EIF4B/TFRC	3
GO:0000217	DNA secondary structure binding	2/271	36/18367	0.0985489716269145	0.507260569260021	YY1/HNRNPD	2
GO:0001618	virus receptor activity	3/271	76/18367	0.102196244065079	0.507260569260021	SCARB1/TFRC/CD55	3
GO:0015631	tubulin binding	9/271	375/18367	0.104684778513431	0.507260569260021	GAPDH/CCSAP/CNN3/ALDOA/KIF21A/FNTA/CAPN6/HOOK3/CCT5	9
GO:0038024	cargo receptor activity	3/271	77/18367	0.105240424273	0.507260569260021	SCARB1/TFRC/ACKR2	3
GO:0140272	exogenous protein binding	3/271	77/18367	0.105240424273	0.507260569260021	SCARB1/TFRC/CD55	3
GO:0005525	GTP binding	9/271	377/18367	0.107226398992344	0.507260569260021	RAB14/RAB1A/RRAGA/ARF1/GSPT1/RHOB/TUBA1C/RABL6/RAB9A	9
GO:0008017	microtubule binding	7/271	271/18367	0.107410519396229	0.507260569260021	GAPDH/CCSAP/CNN3/KIF21A/FNTA/CAPN6/HOOK3	7
GO:0030246	carbohydrate binding	7/271	271/18367	0.107410519396229	0.507260569260021	UGP2/CALR/LGALS14/ENG/ALDOA/SIGLEC6/PAM	7
GO:0030971	receptor tyrosine kinase binding	3/271	78/18367	0.108319987319802	0.507260569260021	CRK/FNTA/YWHAG	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4/271	124/18367	0.111419133788377	0.507260569260021	LDHA/RDH13/HSD17B4/MDH2	4
GO:0016835	carbon-oxygen lyase activity	3/271	79/18367	0.111434277216505	0.507260569260021	ENO1/XRCC6/HSD17B4	3
GO:0046332	SMAD binding	3/271	79/18367	0.111434277216505	0.507260569260021	FOS/YY1/TRIM33	3
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/271	40/18367	0.117519695463421	0.507260569260021	TNFAIP8/SERPINB9	2
GO:0016859	cis-trans isomerase activity	2/271	41/18367	0.122396708651896	0.507260569260021	PPIG/DEGS1	2
GO:0003924	GTPase activity	8/271	337/18367	0.126981835918498	0.507260569260021	RAB14/RAB1A/RRAGA/ARF1/GSPT1/RHOB/TUBA1C/RAB9A	8
GO:0001046	core promoter sequence-specific DNA binding	2/271	42/18367	0.127322269757588	0.507260569260021	FOS/NPM1	2
GO:0008307	structural constituent of muscle	2/271	42/18367	0.127322269757588	0.507260569260021	KRT19/TPM4	2
GO:0004866	endopeptidase inhibitor activity	5/271	180/18367	0.128155459288076	0.507260569260021	GAPDH/TNFAIP8/SERPINB9/SPINT2/FURIN	5
GO:0140297	DNA-binding transcription factor binding	9/271	394/18367	0.130215435449173	0.507260569260021	FOS/CALR/NPM1/MED4/SRI/FHL2/STAT5B/NFKBIA/APEX1	9
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	10/271	450/18367	0.130659441148741	0.507260569260021	FOS/GATA3/YY1/TFAP2C/STAT5B/ATF3/E2F4/FOSB/CREB3L2/GLIS3	10
GO:0016504	peptidase activator activity	2/271	43/18367	0.132293898700619	0.507260569260021	PSMD14/CLPX	2
GO:0030544	Hsp70 protein binding	2/271	43/18367	0.132293898700619	0.507260569260021	ST13/DNAJA2	2
GO:0019001	guanyl nucleotide binding	9/271	398/18367	0.135977720991042	0.507260569260021	RAB14/RAB1A/RRAGA/ARF1/GSPT1/RHOB/TUBA1C/RABL6/RAB9A	9
GO:0032561	guanyl ribonucleotide binding	9/271	398/18367	0.135977720991042	0.507260569260021	RAB14/RAB1A/RRAGA/ARF1/GSPT1/RHOB/TUBA1C/RABL6/RAB9A	9
GO:0004300	enoyl-CoA hydratase activity	1/271	10/18367	0.138157958474091	0.507260569260021	HSD17B4	1
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/271	10/18367	0.138157958474091	0.507260569260021	APEX1	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/271	10/18367	0.138157958474091	0.507260569260021	PTPN12	1
GO:0005522	profilin binding	1/271	10/18367	0.138157958474091	0.507260569260021	CTTN	1
GO:0008526	phosphatidylinositol transfer activity	1/271	10/18367	0.138157958474091	0.507260569260021	PITPNB	1
GO:0015232	heme transmembrane transporter activity	1/271	10/18367	0.138157958474091	0.507260569260021	PGRMC2	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/271	10/18367	0.138157958474091	0.507260569260021	PIK3C2A	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/271	10/18367	0.138157958474091	0.507260569260021	DEGS1	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/271	10/18367	0.138157958474091	0.507260569260021	PGM2	1
GO:0030957	Tat protein binding	1/271	10/18367	0.138157958474091	0.507260569260021	NPM1	1
GO:0034511	U3 snoRNA binding	1/271	10/18367	0.138157958474091	0.507260569260021	SNU13	1
GO:0034713	type I transforming growth factor beta receptor binding	1/271	10/18367	0.138157958474091	0.507260569260021	ENG	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/271	10/18367	0.138157958474091	0.507260569260021	PIK3C2A	1
GO:0070008	serine-type exopeptidase activity	1/271	10/18367	0.138157958474091	0.507260569260021	CPVL	1
GO:0098505	G-rich strand telomeric DNA binding	1/271	10/18367	0.138157958474091	0.507260569260021	HNRNPA1	1
GO:0120016	sphingolipid transfer activity	1/271	10/18367	0.138157958474091	0.507260569260021	PITPNB	1
GO:0001216	DNA-binding transcription activator activity	10/271	456/18367	0.13877581165821	0.507260569260021	FOS/GATA3/YY1/TFAP2C/STAT5B/ATF3/E2F4/FOSB/CREB3L2/GLIS3	10
GO:0033218	amide binding	9/271	400/18367	0.138908087883975	0.507260569260021	INHBA/CALR/FURIN/SCARB1/PPIG/KDELR2/TOMM20/NFKBIA/RPS6KB2	9
GO:0051020	GTPase binding	7/271	291/18367	0.140300652187058	0.507260569260021	ENO1/ERRFI1/YBX3/ERC1/YBX1/ATP6AP1/GOLGA4	7
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3/271	88/18367	0.140915871803318	0.507260569260021	NDUFV2/NDUFB8/NDUFB5	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	4/271	136/18367	0.142051896667983	0.507260569260021	LDHA/RDH13/HSD17B4/MDH2	4
GO:0030414	peptidase inhibitor activity	5/271	187/18367	0.143611858712731	0.507260569260021	GAPDH/TNFAIP8/SERPINB9/SPINT2/FURIN	5
GO:0061980	regulatory RNA binding	2/271	46/18367	0.147461315924072	0.507260569260021	YBX1/HNRNPA1	2
GO:0020037	heme binding	4/271	139/18367	0.15018490889914	0.507260569260021	EIF2AK1/CYCS/STEAP4/PGRMC2	4
GO:0000774	adenyl-nucleotide exchange factor activity	1/271	11/18367	0.150881126380258	0.507260569260021	BAG1	1
GO:0005078	MAP-kinase scaffold activity	1/271	11/18367	0.150881126380258	0.507260569260021	MAP2K2	1
GO:0005536	glucose binding	1/271	11/18367	0.150881126380258	0.507260569260021	UGP2	1
GO:0016832	aldehyde-lyase activity	1/271	11/18367	0.150881126380258	0.507260569260021	ALDOA	1
GO:0019107	myristoyltransferase activity	1/271	11/18367	0.150881126380258	0.507260569260021	NMT1	1
GO:0042608	T cell receptor binding	1/271	11/18367	0.150881126380258	0.507260569260021	EPS8L1	1
GO:0043522	leucine zipper domain binding	1/271	11/18367	0.150881126380258	0.507260569260021	ERC1	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/271	11/18367	0.150881126380258	0.507260569260021	MTMR4	1
GO:0070697	activin receptor binding	1/271	11/18367	0.150881126380258	0.507260569260021	INHBA	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/271	11/18367	0.150881126380258	0.507260569260021	DSP	1
GO:0005044	scavenger receptor activity	2/271	47/18367	0.152593638781666	0.507260569260021	SCARB1/ACKR2	2
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	7/271	299/18367	0.154685348918195	0.507260569260021	FOS/CALR/NPM1/MED4/STAT5B/NFKBIA/APEX1	7
GO:0019838	growth factor binding	4/271	141/18367	0.155704189626385	0.507260569260021	HTRA1/FURIN/ENG/FLT1	4
GO:0120013	lipid transfer activity	2/271	48/18367	0.157760535634017	0.507260569260021	OSBP/PITPNB	2
GO:0019199	transmembrane receptor protein kinase activity	4/271	143/18367	0.161298471675237	0.507260569260021	ENG/FLT1/DDR1/MAP2K2	4
GO:0000340	RNA 7-methylguanosine cap binding	1/271	12/18367	0.163417148103453	0.507260569260021	EIF4E2	1
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/271	12/18367	0.163417148103453	0.507260569260021	APEX1	1
GO:0003995	acyl-CoA dehydrogenase activity	1/271	12/18367	0.163417148103453	0.507260569260021	TECR	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/271	12/18367	0.163417148103453	0.507260569260021	HEXIM1	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/271	12/18367	0.163417148103453	0.507260569260021	ENG	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/271	12/18367	0.163417148103453	0.507260569260021	APEX1	1
GO:0030955	potassium ion binding	1/271	12/18367	0.163417148103453	0.507260569260021	PKM	1
GO:0034452	dynactin binding	1/271	12/18367	0.163417148103453	0.507260569260021	HOOK3	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/271	12/18367	0.163417148103453	0.507260569260021	PIK3C2A	1
GO:0035325	Toll-like receptor binding	1/271	12/18367	0.163417148103453	0.507260569260021	TOLLIP	1
GO:0043047	single-stranded telomeric DNA binding	1/271	12/18367	0.163417148103453	0.507260569260021	HNRNPA1	1
GO:0043422	protein kinase B binding	1/271	12/18367	0.163417148103453	0.507260569260021	SRSF5	1
GO:0061578	Lys63-specific deubiquitinase activity	1/271	12/18367	0.163417148103453	0.507260569260021	PSMD14	1
GO:0070410	co-SMAD binding	1/271	12/18367	0.163417148103453	0.507260569260021	TRIM33	1
GO:0016829	lyase activity	5/271	196/18367	0.164597877806952	0.507260569260021	ENO1/ALDOA/XRCC6/HSD17B4/PAM	5
GO:0016860	intramolecular oxidoreductase activity	2/271	51/18367	0.173447681946304	0.507260569260021	ERP44/PDIA6	2
GO:0051018	protein kinase A binding	2/271	51/18367	0.173447681946304	0.507260569260021	WASF2/AKAP9	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7/271	310/18367	0.175523404109588	0.507260569260021	ENO1/GATA3/YY1/TFAP2C/ATF3/NFIL3/GLIS3	7
GO:0008035	high-density lipoprotein particle binding	1/271	13/18367	0.175768766347199	0.507260569260021	SCARB1	1
GO:0008179	adenylate cyclase binding	1/271	13/18367	0.175768766347199	0.507260569260021	CAP1	1
GO:0008195	phosphatidate phosphatase activity	1/271	13/18367	0.175768766347199	0.507260569260021	LPIN2	1
GO:0016840	carbon-nitrogen lyase activity	1/271	13/18367	0.175768766347199	0.507260569260021	PAM	1
GO:0019104	DNA N-glycosylase activity	1/271	13/18367	0.175768766347199	0.507260569260021	APEX1	1
GO:0031386	protein tag	1/271	13/18367	0.175768766347199	0.507260569260021	UBC	1
GO:0032036	myosin heavy chain binding	1/271	13/18367	0.175768766347199	0.507260569260021	LIMCH1	1
GO:0045159	myosin II binding	1/271	13/18367	0.175768766347199	0.507260569260021	LIMCH1	1
GO:0045504	dynein heavy chain binding	1/271	13/18367	0.175768766347199	0.507260569260021	DYNC1I2	1
GO:0052650	NADP-retinol dehydrogenase activity	1/271	13/18367	0.175768766347199	0.507260569260021	RDH13	1
GO:0060590	ATPase regulator activity	1/271	13/18367	0.175768766347199	0.507260569260021	BAG1	1
GO:0061133	endopeptidase activator activity	1/271	13/18367	0.175768766347199	0.507260569260021	PSMD14	1
GO:0072542	protein phosphatase activator activity	1/271	13/18367	0.175768766347199	0.507260569260021	PPP1R15A	1
GO:0140299	small molecule sensor activity	1/271	13/18367	0.175768766347199	0.507260569260021	EFHD1	1
GO:0004722	protein serine/threonine phosphatase activity	3/271	98/18367	0.176315476675881	0.507260569260021	SSU72/TIMM50/MTMR4	3
GO:0004867	serine-type endopeptidase inhibitor activity	3/271	98/18367	0.176315476675881	0.507260569260021	SERPINB9/SPINT2/FURIN	3
GO:0046906	tetrapyrrole binding	4/271	149/18367	0.178506752593457	0.510198565096262	EIF2AK1/CYCS/STEAP4/PGRMC2	4
GO:0001217	DNA-binding transcription repressor activity	7/271	313/18367	0.181407851448335	0.510198565096262	ENO1/GATA3/YY1/TFAP2C/ATF3/NFIL3/GLIS3	7
GO:0140677	molecular function activator activity	4/271	150/18367	0.181433578588406	0.510198565096262	ARF1/ATP1B3/KRTCAP2/DNAJA2	4
GO:0019887	protein kinase regulator activity	5/271	204/18367	0.184212812867827	0.510198565096262	SH3BP5/NPM1/YWHAG/MAP2K2/HEXIM1	5
GO:0008474	palmitoyl-(protein) hydrolase activity	1/271	14/18367	0.18793868376683	0.510198565096262	ABHD12	1
GO:0035259	glucocorticoid receptor binding	1/271	14/18367	0.18793868376683	0.510198565096262	STAT5B	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/271	14/18367	0.18793868376683	0.510198565096262	HSD17B4	1
GO:0071837	HMG box domain binding	1/271	14/18367	0.18793868376683	0.510198565096262	GATA3	1
GO:0098599	palmitoyl hydrolase activity	1/271	14/18367	0.18793868376683	0.510198565096262	ABHD12	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/271	14/18367	0.18793868376683	0.510198565096262	MTMR4	1
GO:0004725	protein tyrosine phosphatase activity	3/271	102/18367	0.191110709985709	0.510198565096262	PTPN12/TIMM50/MTMR4	3
GO:0001846	opsonin binding	1/271	15/18367	0.199929563552107	0.510198565096262	CALR	1
GO:0005545	1-phosphatidylinositol binding	1/271	15/18367	0.199929563552107	0.510198565096262	SCARB1	1
GO:0030280	structural constituent of skin epidermis	1/271	15/18367	0.199929563552107	0.510198565096262	KRT10	1
GO:0030548	acetylcholine receptor regulator activity	1/271	15/18367	0.199929563552107	0.510198565096262	FNTA	1
GO:0042809	vitamin D receptor binding	1/271	15/18367	0.199929563552107	0.510198565096262	MED4	1
GO:0043138	3'-5' DNA helicase activity	1/271	15/18367	0.199929563552107	0.510198565096262	ASCC3	1
GO:0047372	acylglycerol lipase activity	1/271	15/18367	0.199929563552107	0.510198565096262	ABHD12	1
GO:0051371	muscle alpha-actinin binding	1/271	15/18367	0.199929563552107	0.510198565096262	PDLIM2	1
GO:0070742	C2H2 zinc finger domain binding	1/271	15/18367	0.199929563552107	0.510198565096262	SRRM2	1
GO:0071933	Arp2/3 complex binding	1/271	15/18367	0.199929563552107	0.510198565096262	WASF2	1
GO:0099602	neurotransmitter receptor regulator activity	1/271	15/18367	0.199929563552107	0.510198565096262	FNTA	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/271	56/18367	0.20009646326266	0.510198565096262	TNFAIP8/SERPINB9	2
GO:0051287	NAD binding	2/271	56/18367	0.20009646326266	0.510198565096262	GAPDH/LDHA	2
GO:1990782	protein tyrosine kinase binding	3/271	105/18367	0.202406489603688	0.512859074028273	CRK/FNTA/YWHAG	3
GO:0022853	active ion transmembrane transporter activity	6/271	267/18367	0.203046436371788	0.512859074028273	ATP1B3/COX7A2L/ATP6V1B2/SLC38A2/ATP6V1D/SLC38A1	6
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	2/271	58/18367	0.210889563919161	0.513145442075459	FNTA/SRM	2
GO:0140030	modification-dependent protein binding	4/271	160/18367	0.211527374904134	0.513145442075459	PSMD4/RAD23A/ZFAND6/KMT2E	4
GO:0016004	phospholipase activator activity	1/271	16/18367	0.211744030001398	0.513145442075459	ARF1	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/271	16/18367	0.211744030001398	0.513145442075459	PIK3C2A	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/271	16/18367	0.211744030001398	0.513145442075459	APEX1	1
GO:0017070	U6 snRNA binding	1/271	16/18367	0.211744030001398	0.513145442075459	EIF5A	1
GO:0032183	SUMO binding	1/271	16/18367	0.211744030001398	0.513145442075459	TOLLIP	1
GO:0035497	cAMP response element binding	1/271	16/18367	0.211744030001398	0.513145442075459	CREB3L2	1
GO:0036122	BMP binding	1/271	16/18367	0.211744030001398	0.513145442075459	ENG	1
GO:0016791	phosphatase activity	6/271	275/18367	0.221654251935903	0.513593811833724	PTPN12/SSU72/IMPA2/TIMM50/LPIN2/MTMR4	6
GO:0000400	four-way junction DNA binding	1/271	17/18367	0.223384669087531	0.513593811833724	YY1	1
GO:0004659	prenyltransferase activity	1/271	17/18367	0.223384669087531	0.513593811833724	FNTA	1
GO:0005149	interleukin-1 receptor binding	1/271	17/18367	0.223384669087531	0.513593811833724	TOLLIP	1
GO:0008525	phosphatidylcholine transporter activity	1/271	17/18367	0.223384669087531	0.513593811833724	PITPNB	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/271	17/18367	0.223384669087531	0.513593811833724	STEAP4	1
GO:0030169	low-density lipoprotein particle binding	1/271	17/18367	0.223384669087531	0.513593811833724	SCARB1	1
GO:0030275	LRR domain binding	1/271	17/18367	0.223384669087531	0.513593811833724	ERC1	1
GO:0031420	alkali metal ion binding	1/271	17/18367	0.223384669087531	0.513593811833724	PKM	1
GO:0031489	myosin V binding	1/271	17/18367	0.223384669087531	0.513593811833724	RAB14	1
GO:0034185	apolipoprotein binding	1/271	17/18367	0.223384669087531	0.513593811833724	SCARB1	1
GO:0052745	inositol phosphate phosphatase activity	1/271	17/18367	0.223384669087531	0.513593811833724	IMPA2	1
GO:0005507	copper ion binding	2/271	61/18367	0.227180504246786	0.515720275960452	CUTA/PAM	2
GO:0043621	protein self-association	2/271	61/18367	0.227180504246786	0.515720275960452	CRK/MDH2	2
GO:0000287	magnesium ion binding	5/271	221/18367	0.228461193950774	0.515720275960452	ENO1/ARF1/PDCD6/PKM/PGM2	5
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/271	18/18367	0.234854029015447	0.515720275960452	HSD17B4	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/271	18/18367	0.234854029015447	0.515720275960452	MTMR4	1
GO:0004708	MAP kinase kinase activity	1/271	18/18367	0.234854029015447	0.515720275960452	MAP2K2	1
GO:0030228	lipoprotein particle receptor activity	1/271	18/18367	0.234854029015447	0.515720275960452	SCARB1	1
GO:0046624	sphingolipid transporter activity	1/271	18/18367	0.234854029015447	0.515720275960452	PITPNB	1
GO:0060229	lipase activator activity	1/271	18/18367	0.234854029015447	0.515720275960452	ARF1	1
GO:0070122	isopeptidase activity	1/271	18/18367	0.234854029015447	0.515720275960452	PSMD14	1
GO:0098918	structural constituent of synapse	1/271	18/18367	0.234854029015447	0.515720275960452	ERC1	1
GO:0016836	hydro-lyase activity	2/271	64/18367	0.243556280159229	0.525520579266721	ENO1/HSD17B4	2
GO:0000339	RNA cap binding	1/271	19/18367	0.246154620771773	0.525520579266721	EIF4E2	1
GO:0003746	translation elongation factor activity	1/271	19/18367	0.246154620771773	0.525520579266721	EIF5A	1
GO:0004129	cytochrome-c oxidase activity	1/271	19/18367	0.246154620771773	0.525520579266721	COX7A2L	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/271	19/18367	0.246154620771773	0.525520579266721	ENG	1
GO:0052742	phosphatidylinositol kinase activity	1/271	19/18367	0.246154620771773	0.525520579266721	PIK3C2A	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/271	19/18367	0.246154620771773	0.525520579266721	MTMR4	1
GO:0004721	phosphoprotein phosphatase activity	4/271	174/18367	0.255737286944559	0.530350338093984	PTPN12/SSU72/TIMM50/MTMR4	4
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/271	20/18367	0.257288918666412	0.530350338093984	FOS	1
GO:0016018	cyclosporin A binding	1/271	20/18367	0.257288918666412	0.530350338093984	PPIG	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	1/271	20/18367	0.257288918666412	0.530350338093984	COX7A2L	1
GO:0019211	phosphatase activator activity	1/271	20/18367	0.257288918666412	0.530350338093984	PPP1R15A	1
GO:0031418	L-ascorbic acid binding	1/271	20/18367	0.257288918666412	0.530350338093984	PAM	1
GO:0031681	G-protein beta-subunit binding	1/271	20/18367	0.257288918666412	0.530350338093984	CCT5	1
GO:0031690	adrenergic receptor binding	1/271	20/18367	0.257288918666412	0.530350338093984	ARRDC3	1
GO:0042288	MHC class I protein binding	1/271	20/18367	0.257288918666412	0.530350338093984	BCAP31	1
GO:0019207	kinase regulator activity	5/271	233/18367	0.261389115157766	0.536745587614038	SH3BP5/NPM1/YWHAG/MAP2K2/HEXIM1	5
GO:0001848	complement binding	1/271	21/18367	0.268259360866304	0.539626760702648	CALR	1
GO:0015662	P-type ion transporter activity	1/271	21/18367	0.268259360866304	0.539626760702648	ATP1B3	1
GO:0140358	P-type transmembrane transporter activity	1/271	21/18367	0.268259360866304	0.539626760702648	ATP1B3	1
GO:1990381	ubiquitin-specific protease binding	1/271	21/18367	0.268259360866304	0.539626760702648	RAD23A	1
GO:0003777	microtubule motor activity	2/271	69/18367	0.270935357702562	0.539626760702648	DYNC1I2/KIF21A	2
GO:0030674	protein-macromolecule adaptor activity	6/271	296/18367	0.272908238314734	0.539626760702648	ATP1B3/PDCD6/HERPUD1/ST13/CRK/MAP2K2	6
GO:0004714	transmembrane receptor protein tyrosine kinase activity	3/271	124/18367	0.276795966802092	0.539626760702648	FLT1/DDR1/MAP2K2	3
GO:0004602	glutathione peroxidase activity	1/271	22/18367	0.279068349921424	0.539626760702648	GPX3	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/271	22/18367	0.279068349921424	0.539626760702648	RDH13	1
GO:0008320	protein transmembrane transporter activity	1/271	22/18367	0.279068349921424	0.539626760702648	TOMM20	1
GO:0033691	sialic acid binding	1/271	22/18367	0.279068349921424	0.539626760702648	SIGLEC6	1
GO:0070034	telomerase RNA binding	1/271	22/18367	0.279068349921424	0.539626760702648	HNRNPC	1
GO:0031491	nucleosome binding	2/271	71/18367	0.281887458061805	0.539626760702648	HP1BP3/HNRNPC	2
GO:0003678	DNA helicase activity	2/271	72/18367	0.287358919346775	0.539626760702648	ASCC3/XRCC6	2
GO:0030276	clathrin binding	2/271	72/18367	0.287358919346775	0.539626760702648	GAK/PIK3C2A	2
GO:0004529	exodeoxyribonuclease activity	1/271	23/18367	0.289718253283173	0.539626760702648	APEX1	1
GO:0016493	C-C chemokine receptor activity	1/271	23/18367	0.289718253283173	0.539626760702648	ACKR2	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1/271	23/18367	0.289718253283173	0.539626760702648	ADI1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/271	23/18367	0.289718253283173	0.539626760702648	APEX1	1
GO:0120015	sterol transfer activity	1/271	23/18367	0.289718253283173	0.539626760702648	OSBP	1
GO:0140103	catalytic activity, acting on a glycoprotein	1/271	23/18367	0.289718253283173	0.539626760702648	MGAT1	1
GO:0008514	organic anion transmembrane transporter activity	4/271	185/18367	0.291674620537968	0.539626760702648	SERINC3/SLC16A3/SLC38A2/SLC38A1	4
GO:0015370	solute:sodium symporter activity	2/271	73/18367	0.292825860903844	0.539626760702648	SLC38A2/SLC38A1	2
GO:0042578	phosphoric ester hydrolase activity	7/271	366/18367	0.296686943755915	0.539626760702648	PTPN12/SSU72/IMPA2/TIMM50/LPIN2/MTMR4/APEX1	7
GO:0031072	heat shock protein binding	3/271	129/18367	0.296878651525133	0.539626760702648	ST13/DNAJA2/BAG1	3
GO:0017022	myosin binding	2/271	74/18367	0.298287228302938	0.539626760702648	RAB14/LIMCH1	2
GO:0003707	steroid hormone receptor activity	1/271	24/18367	0.300211403815241	0.539626760702648	PGRMC2	1
GO:0004622	lysophospholipase activity	1/271	24/18367	0.300211403815241	0.539626760702648	ABHD12	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	1/271	24/18367	0.300211403815241	0.539626760702648	ADI1	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/271	24/18367	0.300211403815241	0.539626760702648	GAPDH	1
GO:0019957	C-C chemokine binding	1/271	24/18367	0.300211403815241	0.539626760702648	ACKR2	1
GO:0043274	phospholipase binding	1/271	24/18367	0.300211403815241	0.539626760702648	SRSF3	1
GO:0043495	protein-membrane adaptor activity	1/271	24/18367	0.300211403815241	0.539626760702648	PDCD6	1
GO:0050431	transforming growth factor beta binding	1/271	24/18367	0.300211403815241	0.539626760702648	ENG	1
GO:0051537	2 iron, 2 sulfur cluster binding	1/271	24/18367	0.300211403815241	0.539626760702648	NDUFV2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/271	24/18367	0.300211403815241	0.539626760702648	INHBA	1
GO:0120014	phospholipid transfer activity	1/271	24/18367	0.300211403815241	0.539626760702648	PITPNB	1
GO:0015078	proton transmembrane transporter activity	3/271	130/18367	0.300907115633447	0.539626760702648	COX7A2L/ATP6V1B2/ATP6V1D	3
GO:0060090	molecular adaptor activity	7/271	369/18367	0.303694727579023	0.54281648982563	ATP1B3/PDCD6/HERPUD1/ST13/CRK/MAP2K2/AKAP9	7
GO:0005160	transforming growth factor beta receptor binding	1/271	25/18367	0.310550100297064	0.551386092916057	ENG	1
GO:0008266	poly(U) RNA binding	1/271	25/18367	0.310550100297064	0.551386092916057	HNRNPC	1
GO:0008236	serine-type peptidase activity	4/271	191/18367	0.31156388893398	0.551386092916057	HTRA1/FURIN/SEC11A/CPVL	4
GO:0044325	transmembrane transporter binding	3/271	133/18367	0.313007503910473	0.552124711815851	HERPUD1/SRI/AKAP9	3
GO:0001637	G protein-coupled chemoattractant receptor activity	1/271	26/18367	0.320736607919978	0.559609935288011	ACKR2	1
GO:0004950	chemokine receptor activity	1/271	26/18367	0.320736607919978	0.559609935288011	ACKR2	1
GO:0038187	pattern recognition receptor activity	1/271	26/18367	0.320736607919978	0.559609935288011	SCARB1	1
GO:0017171	serine hydrolase activity	4/271	195/18367	0.324895906953233	0.559609935288011	HTRA1/FURIN/SEC11A/CPVL	4
GO:0004713	protein tyrosine kinase activity	3/271	136/18367	0.325120460278177	0.559609935288011	FLT1/DDR1/MAP2K2	3
GO:0008139	nuclear localization sequence binding	1/271	27/18367	0.330773158776185	0.559609935288011	NFKBIA	1
GO:0016866	intramolecular transferase activity	1/271	27/18367	0.330773158776185	0.559609935288011	PGM2	1
GO:0022884	macromolecule transmembrane transporter activity	1/271	27/18367	0.330773158776185	0.559609935288011	TOMM20	1
GO:0023026	MHC class II protein complex binding	1/271	27/18367	0.330773158776185	0.559609935288011	PKM	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	1/271	27/18367	0.330773158776185	0.559609935288011	MTMR4	1
GO:0043425	bHLH transcription factor binding	1/271	27/18367	0.330773158776185	0.559609935288011	FHL2	1
GO:0051393	alpha-actinin binding	1/271	27/18367	0.330773158776185	0.559609935288011	PDLIM2	1
GO:0051959	dynein light intermediate chain binding	1/271	27/18367	0.330773158776185	0.559609935288011	HOOK3	1
GO:0031267	small GTPase binding	5/271	259/18367	0.335796090259299	0.565368512813477	ERRFI1/YBX3/ERC1/ATP6AP1/GOLGA4	5
GO:0035591	signaling adaptor activity	2/271	81/18367	0.336278669331436	0.565368512813477	CRK/MAP2K2	2
GO:0001968	fibronectin binding	1/271	28/18367	0.340661952340615	0.565667069010034	FSTL3	1
GO:0008187	poly-pyrimidine tract binding	1/271	28/18367	0.340661952340615	0.565667069010034	HNRNPC	1
GO:0046875	ephrin receptor binding	1/271	28/18367	0.340661952340615	0.565667069010034	CRK	1
GO:0050681	androgen receptor binding	1/271	28/18367	0.340661952340615	0.565667069010034	CALR	1
GO:0070851	growth factor receptor binding	3/271	141/18367	0.345303427290104	0.571609981175619	GATA3/TOLLIP/TIMM50	3
GO:0004033	aldo-keto reductase (NADP) activity	1/271	29/18367	0.350405155945812	0.573002960178865	RDH13	1
GO:0005520	insulin-like growth factor binding	1/271	29/18367	0.350405155945812	0.573002960178865	HTRA1	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/271	29/18367	0.350405155945812	0.573002960178865	TECR	1
GO:0033612	receptor serine/threonine kinase binding	1/271	29/18367	0.350405155945812	0.573002960178865	INHBA	1
GO:0030165	PDZ domain binding	2/271	84/18367	0.352384251528659	0.574493113098237	ERC1/MAP2K2	2
GO:0046982	protein heterodimerization activity	6/271	328/18367	0.355412910746706	0.577406653124966	RRAGA/TPM4/KRT10/TRMT112/SRI/ATF3	6
GO:0015293	symporter activity	3/271	144/18367	0.357391106859877	0.577406653124966	SLC16A3/SLC38A2/SLC38A1	3
GO:0016922	nuclear receptor binding	3/271	144/18367	0.357391106859877	0.577406653124966	CALR/MED4/STAT5B	3
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/271	30/18367	0.360004905249917	0.578157131416285	HSD17B4	1
GO:0046966	thyroid hormone receptor binding	1/271	30/18367	0.360004905249917	0.578157131416285	MED4	1
GO:0042562	hormone binding	2/271	86/18367	0.363046492277807	0.581306585849583	INHBA/CALR	2
GO:0008157	protein phosphatase 1 binding	1/271	31/18367	0.369463304697878	0.58290691474328	PPP1R15A	1
GO:0031210	phosphatidylcholine binding	1/271	31/18367	0.369463304697878	0.58290691474328	PITPNB	1
GO:0071813	lipoprotein particle binding	1/271	31/18367	0.369463304697878	0.58290691474328	SCARB1	1
GO:0071814	protein-lipid complex binding	1/271	31/18367	0.369463304697878	0.58290691474328	SCARB1	1
GO:0140318	protein transporter activity	1/271	31/18367	0.369463304697878	0.58290691474328	TOMM20	1
GO:0035091	phosphatidylinositol binding	5/271	271/18367	0.370842788268553	0.583372573358133	GOLPH3/SCARB1/PIK3C2A/OSBP/PITPNB	5
GO:0008276	protein methyltransferase activity	2/271	88/18367	0.373642256925991	0.584113160631146	TRMT112/NTMT1	2
GO:0051219	phosphoprotein binding	2/271	88/18367	0.373642256925991	0.584113160631146	RRAGA/CRK	2
GO:0030515	snoRNA binding	1/271	32/18367	0.378782427975959	0.584113160631146	SNU13	1
GO:0031624	ubiquitin conjugating enzyme binding	1/271	32/18367	0.378782427975959	0.584113160631146	TOLLIP	1
GO:0050699	WW domain binding	1/271	32/18367	0.378782427975959	0.584113160631146	TCEAL8	1
GO:0071889	14-3-3 protein binding	1/271	32/18367	0.378782427975959	0.584113160631146	ZFP36L1	1
GO:0051117	ATPase binding	2/271	89/18367	0.378913555874108	0.584113160631146	ATP1B3/SNU13	2
GO:0001530	lipopolysaccharide binding	1/271	33/18367	0.387964318459652	0.594657559348412	SCARB1	1
GO:0019956	chemokine binding	1/271	33/18367	0.387964318459652	0.594657559348412	ACKR2	1
GO:0015081	sodium ion transmembrane transporter activity	3/271	152/18367	0.389450225119729	0.595239264529585	ATP1B3/SLC38A2/SLC38A1	3
GO:0043130	ubiquitin binding	2/271	92/18367	0.39461372178289	0.598296673485844	RAD23A/TOLLIP	2
GO:0016229	steroid dehydrogenase activity	1/271	34/18367	0.397010989655105	0.598296673485844	HSD17B4	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/271	34/18367	0.397010989655105	0.598296673485844	APEX1	1
GO:0045505	dynein intermediate chain binding	1/271	34/18367	0.397010989655105	0.598296673485844	HOOK3	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	1/271	34/18367	0.397010989655105	0.598296673485844	MTMR4	1
GO:0051015	actin filament binding	4/271	217/18367	0.3984541860262	0.598794279558927	ARPC5L/TPM4/ACTR3/CTTN	4
GO:0016410	N-acyltransferase activity	2/271	94/18367	0.404979992784247	0.606905950189206	ALAS1/NMT1	2
GO:0015248	sterol transporter activity	1/271	36/18367	0.414706581462907	0.612945441832539	OSBP	1
GO:0023023	MHC protein complex binding	1/271	36/18367	0.414706581462907	0.612945441832539	PKM	1
GO:0042805	actinin binding	1/271	36/18367	0.414706581462907	0.612945441832539	PDLIM2	1
GO:0061631	ubiquitin conjugating enzyme activity	1/271	36/18367	0.414706581462907	0.612945441832539	UBE2J1	1
GO:0097718	disordered domain specific binding	1/271	36/18367	0.414706581462907	0.612945441832539	GAPDH	1
GO:0015035	protein-disulfide reductase activity	1/271	37/18367	0.423359383624467	0.618933011929248	PDIA6	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/271	37/18367	0.423359383624467	0.618933011929248	GAPDH	1
GO:0071855	neuropeptide receptor binding	1/271	37/18367	0.423359383624467	0.618933011929248	KISS1	1
GO:0071949	FAD binding	1/271	37/18367	0.423359383624467	0.618933011929248	STEAP4	1
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/271	38/18367	0.431884730435038	0.626291064620083	PPIG	1
GO:0004520	endodeoxyribonuclease activity	1/271	38/18367	0.431884730435038	0.626291064620083	APEX1	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/271	38/18367	0.431884730435038	0.626291064620083	TOLLIP	1
GO:0005496	steroid binding	2/271	100/18367	0.435551312404762	0.629910231381081	OSBP/PGRMC2	2
GO:0140097	catalytic activity, acting on DNA	4/271	229/18367	0.438128539308833	0.629981534416076	TOP1/ASCC3/XRCC6/APEX1	4
GO:0016776	phosphotransferase activity, phosphate group as acceptor	1/271	39/18367	0.440284492454358	0.629981534416076	PMVK	1
GO:0050997	quaternary ammonium group binding	1/271	39/18367	0.440284492454358	0.629981534416076	PITPNB	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/271	39/18367	0.440284492454358	0.629981534416076	UBE2J1	1
GO:0003925	G protein activity	1/271	40/18367	0.448560512890023	0.632842781085486	RAB1A	1
GO:0031492	nucleosomal DNA binding	1/271	40/18367	0.448560512890023	0.632842781085486	HNRNPC	1
GO:0042169	SH2 domain binding	1/271	40/18367	0.448560512890023	0.632842781085486	CRK	1
GO:0042287	MHC protein binding	1/271	40/18367	0.448560512890023	0.632842781085486	BCAP31	1
GO:0043014	alpha-tubulin binding	1/271	40/18367	0.448560512890023	0.632842781085486	FNTA	1
GO:0008238	exopeptidase activity	2/271	103/18367	0.450518188021824	0.632842781085486	TFRC/CPVL	2
GO:0031490	chromatin DNA binding	2/271	103/18367	0.450518188021824	0.632842781085486	HNRNPC/APEX1	2
GO:0015294	solute:cation symporter activity	2/271	104/18367	0.455457299064372	0.638114653376647	SLC38A2/SLC38A1	2
GO:0048487	beta-tubulin binding	1/271	41/18367	0.456714607995976	0.638214179485286	CCT5	1
GO:0015036	disulfide oxidoreductase activity	1/271	42/18367	0.464748567465205	0.64775836605254	PDIA6	1
GO:0004180	carboxypeptidase activity	1/271	43/18367	0.472664154816743	0.653710322085881	CPVL	1
GO:0005246	calcium channel regulator activity	1/271	43/18367	0.472664154816743	0.653710322085881	SRI	1
GO:0016790	thiolester hydrolase activity	1/271	43/18367	0.472664154816743	0.653710322085881	ABHD12	1
GO:0004252	serine-type endopeptidase activity	3/271	174/18367	0.475072466006749	0.65535637618367	HTRA1/FURIN/SEC11A	3
GO:0001784	phosphotyrosine residue binding	1/271	44/18367	0.48046310777705	0.656063837522976	CRK	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/271	44/18367	0.48046310777705	0.656063837522976	MAP2K2	1
GO:0008375	acetylglucosaminyltransferase activity	1/271	44/18367	0.48046310777705	0.656063837522976	MGAT1	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/271	44/18367	0.48046310777705	0.656063837522976	GAPDH	1
GO:0008047	enzyme activator activity	2/271	110/18367	0.484545569625631	0.659963332806555	ARF1/KRTCAP2	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/271	45/18367	0.488147138655859	0.661415392480791	APEX1	1
GO:0008094	ATP-dependent activity, acting on DNA	2/271	111/18367	0.489299862838949	0.661415392480791	ASCC3/XRCC6	2
GO:0032182	ubiquitin-like protein binding	2/271	111/18367	0.489299862838949	0.661415392480791	RAD23A/TOLLIP	2
GO:0008509	anion transmembrane transporter activity	5/271	314/18367	0.494818802827467	0.667199288023001	SERINC3/SLC16A3/SLC38A2/SLC38A1/CLDN4	5
GO:0003774	cytoskeletal motor activity	2/271	114/18367	0.503397029133138	0.677069004184071	DYNC1I2/KIF21A	2
GO:0003735	structural constituent of ribosome	3/271	182/18367	0.504862663484648	0.677346915099104	RPL36A/RPL17/MRPL9	3
GO:0004674	protein serine/threonine kinase activity	6/271	386/18367	0.50632082575951	0.677613443429395	EIF2AK1/TOP1/ENG/GAK/MAP2K2/RPS6KB2	6
GO:0015026	coreceptor activity	1/271	48/18367	0.510526448390327	0.678180812923446	ENG	1
GO:0048020	CCR chemokine receptor binding	1/271	48/18367	0.510526448390327	0.678180812923446	CNIH4	1
GO:0070888	E-box binding	1/271	48/18367	0.510526448390327	0.678180812923446	GATA3	1
GO:0043539	protein serine/threonine kinase activator activity	1/271	49/18367	0.51776741855716	0.686105594048651	MAP2K2	1
GO:0003714	transcription corepressor activity	3/271	187/18367	0.523034923517773	0.688773397385109	N4BP2L2/FHL2/APEX1	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/271	50/18367	0.524901659717276	0.688773397385109	HEXIM1	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/271	50/18367	0.524901659717276	0.688773397385109	APEX1	1
GO:0030159	signaling receptor complex adaptor activity	1/271	50/18367	0.524901659717276	0.688773397385109	CRK	1
GO:0004601	peroxidase activity	1/271	51/18367	0.531930739272696	0.696298631943334	GPX3	1
GO:0008237	metallopeptidase activity	3/271	190/18367	0.533762603725107	0.697000681563368	PAPPA2/TFRC/PSMD14	3
GO:0016830	carbon-carbon lyase activity	1/271	52/18367	0.538856201691188	0.700252745192896	ALDOA	1
GO:0017046	peptide hormone binding	1/271	52/18367	0.538856201691188	0.700252745192896	INHBA	1
GO:0003713	transcription coactivator activity	4/271	262/18367	0.542411113920221	0.70317392599778	NPM1/MED4/LPIN2/APEX1	4
GO:0050661	NADP binding	1/271	53/18367	0.545679568840611	0.704018244691244	GAPDH	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/271	53/18367	0.545679568840611	0.704018244691244	SLC16A3	1
GO:0008408	3'-5' exonuclease activity	1/271	54/18367	0.552402340318398	0.709289878499518	APEX1	1
GO:0015459	potassium channel regulator activity	1/271	54/18367	0.552402340318398	0.709289878499518	AKAP9	1
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	1/271	55/18367	0.559025993776254	0.714384761642814	GPX3	1
GO:0030170	pyridoxal phosphate binding	1/271	55/18367	0.559025993776254	0.714384761642814	ALAS1	1
GO:0030374	nuclear receptor coactivator activity	1/271	56/18367	0.565551985240138	0.715922277786339	MED4	1
GO:0042054	histone methyltransferase activity	1/271	56/18367	0.565551985240138	0.715922277786339	NTMT1	1
GO:0045309	protein phosphorylated amino acid binding	1/271	56/18367	0.565551985240138	0.715922277786339	CRK	1
GO:0070279	vitamin B6 binding	1/271	56/18367	0.565551985240138	0.715922277786339	ALAS1	1
GO:0004536	deoxyribonuclease activity	1/271	57/18367	0.571981749425596	0.717396623327433	APEX1	1
GO:0005548	phospholipid transporter activity	1/271	57/18367	0.571981749425596	0.717396623327433	PITPNB	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/271	57/18367	0.571981749425596	0.717396623327433	PDIA6	1
GO:0016887	ATP hydrolysis activity	4/271	272/18367	0.572050467300128	0.717396623327433	ACIN1/ASCC3/KIF21A/CLPX	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/271	58/18367	0.578316700048516	0.723568336339771	SLC16A3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/271	59/18367	0.584558230131363	0.727448994498247	APEX1	1
GO:0036002	pre-mRNA binding	1/271	59/18367	0.584558230131363	0.727448994498247	HNRNPA1	1
GO:0003712	transcription coregulator activity	7/271	489/18367	0.585474748360113	0.727448994498247	NPM1/N4BP2L2/MED4/FHL2/EWSR1/LPIN2/APEX1	7
GO:0001786	phosphatidylserine binding	1/271	60/18367	0.59070771230497	0.728900800963472	SCARB1	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	1/271	60/18367	0.59070771230497	0.728900800963472	TECR	1
GO:0032934	sterol binding	1/271	60/18367	0.59070771230497	0.728900800963472	OSBP	1
GO:1990841	promoter-specific chromatin binding	1/271	62/18367	0.602735923269727	0.742041022240534	E2F4	1
GO:0019955	cytokine binding	2/271	139/18367	0.610703583664222	0.748424892964354	ENG/ACKR2	2
GO:0099106	ion channel regulator activity	2/271	139/18367	0.610703583664222	0.748424892964354	SRI/AKAP9	2
GO:0030145	manganese ion binding	1/271	65/18367	0.620121056311294	0.758238927944264	MGAT1	1
GO:0016247	channel regulator activity	2/271	145/18367	0.633684066717037	0.771555085373181	SRI/AKAP9	2
GO:0019843	rRNA binding	1/271	68/18367	0.636748063021733	0.771555085373181	NPM1	1
GO:0051536	iron-sulfur cluster binding	1/271	68/18367	0.636748063021733	0.771555085373181	NDUFV2	1
GO:0051540	metal cluster binding	1/271	68/18367	0.636748063021733	0.771555085373181	NDUFV2	1
GO:0004521	endoribonuclease activity	1/271	69/18367	0.642127661629368	0.774584488691928	APEX1	1
GO:0005518	collagen binding	1/271	69/18367	0.642127661629368	0.774584488691928	DDR1	1
GO:0019842	vitamin binding	2/271	148/18367	0.644772169465588	0.776034512690126	PAM/ALAS1	2
GO:0004857	enzyme inhibitor activity	1/271	70/18367	0.647427880434616	0.77749151712907	RNH1	1
GO:0019903	protein phosphatase binding	2/271	150/18367	0.652016333537899	0.778647920523764	PPP1R15A/MTMR4	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/271	71/18367	0.652649886468514	0.778647920523764	HINT1	1
GO:0005506	iron ion binding	2/271	151/18367	0.65559425607275	0.778647920523764	CALR/ADI1	2
GO:0000049	tRNA binding	1/271	72/18367	0.657794829667411	0.778647920523764	EIF2A	1
GO:0008235	metalloexopeptidase activity	1/271	72/18367	0.657794829667411	0.778647920523764	TFRC	1
GO:0042379	chemokine receptor binding	1/271	72/18367	0.657794829667411	0.778647920523764	CNIH4	1
GO:0035064	methylated histone binding	1/271	73/18367	0.662863843122461	0.778647920523764	KMT2E	1
GO:0106306	protein serine phosphatase activity	1/271	73/18367	0.662863843122461	0.778647920523764	SSU72	1
GO:0106307	protein threonine phosphatase activity	1/271	73/18367	0.662863843122461	0.778647920523764	SSU72	1
GO:0140034	methylation-dependent protein binding	1/271	73/18367	0.662863843122461	0.778647920523764	KMT2E	1
GO:0005319	lipid transporter activity	2/271	154/18367	0.666152347944827	0.7794091698679	OSBP/PITPNB	2
GO:0005254	chloride channel activity	1/271	74/18367	0.667858043325468	0.7794091698679	CLDN4	1
GO:0019905	syntaxin binding	1/271	74/18367	0.667858043325468	0.7794091698679	TMED9	1
GO:0004386	helicase activity	2/271	156/18367	0.67304556036229	0.783763011850459	ASCC3/XRCC6	2
GO:0015291	secondary active transmembrane transporter activity	3/271	240/18367	0.690608583291108	0.802478224212994	SLC16A3/SLC38A2/SLC38A1	3
GO:0004527	exonuclease activity	1/271	80/18367	0.69631265859494	0.807362522250167	APEX1	1
GO:0001540	amyloid-beta binding	1/271	84/18367	0.713919550795442	0.825997243716016	SCARB1	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	2/271	170/18367	0.7181130377416	0.827344904192249	PAM/DEGS1	2
GO:0050660	flavin adenine dinucleotide binding	1/271	85/18367	0.718159981891785	0.827344904192249	STEAP4	1
GO:0016209	antioxidant activity	1/271	86/18367	0.722337787651949	0.830379764437497	GPX3	1
GO:0005253	anion channel activity	1/271	87/18367	0.72645388959092	0.832257057911011	CLDN4	1
GO:1901981	phosphatidylinositol phosphate binding	2/271	173/18367	0.727064716018913	0.832257057911011	GOLPH3/OSBP	2
GO:0048306	calcium-dependent protein binding	1/271	88/18367	0.730509195713505	0.834424516547485	PDCD6	1
GO:0008081	phosphoric diester hydrolase activity	1/271	89/18367	0.73450460071168	0.83512057228195	APEX1	1
GO:0019888	protein phosphatase regulator activity	1/271	89/18367	0.73450460071168	0.83512057228195	PPP1R15A	1
GO:0031406	carboxylic acid binding	2/271	176/18367	0.735775374092276	0.83512057228195	SIGLEC6/PAM	2
GO:0051213	dioxygenase activity	1/271	92/18367	0.746140160251087	0.845101907821232	ADI1	1
GO:0072341	modified amino acid binding	1/271	93/18367	0.749904648162001	0.847581304015035	SCARB1	1
GO:0004896	cytokine receptor activity	1/271	97/18367	0.764414521457575	0.862169837618817	ACKR2	1
GO:0004842	ubiquitin-protein transferase activity	5/271	433/18367	0.769006102183525	0.865534064800704	TTC3/UBE2J1/RBBP6/TRIM33/RNF10	5
GO:0008022	protein C-terminus binding	2/271	189/18367	0.770833981464784	0.865780129494893	NCL/XRCC6	2
GO:0030295	protein kinase activator activity	1/271	101/18367	0.778085496089439	0.872104160200246	MAP2K2	1
GO:0106310	protein serine kinase activity	4/271	360/18367	0.780956535633012	0.872160381206819	EIF2AK1/GAK/MAP2K2/RPS6KB2	4
GO:0004497	monooxygenase activity	1/271	102/18367	0.7813778879957	0.872160381206819	PAM	1
GO:0004620	phospholipase activity	1/271	104/18367	0.787817380558833	0.875901992800733	ABHD12	1
GO:0019902	phosphatase binding	2/271	196/18367	0.787986179396942	0.875901992800733	PPP1R15A/MTMR4	2
GO:0019208	phosphatase regulator activity	1/271	107/18367	0.79712398676206	0.882412972999976	PPP1R15A	1
GO:0019209	kinase activator activity	1/271	107/18367	0.79712398676206	0.882412972999976	MAP2K2	1
GO:0005516	calmodulin binding	2/271	201/18367	0.799538426661202	0.883268323498413	CNN3/EWSR1	2
GO:0000149	SNARE binding	1/271	110/18367	0.80602383331289	0.888569993266201	TMED9	1
GO:0004222	metalloendopeptidase activity	1/271	111/18367	0.808903142135381	0.888569993266201	PAPPA2	1
GO:0019787	ubiquitin-like protein transferase activity	5/271	458/18367	0.809292373049142	0.888569993266201	TTC3/UBE2J1/RBBP6/TRIM33/RNF10	5
GO:0001664	G protein-coupled receptor binding	3/271	295/18367	0.813591144906196	0.890690312589476	KISS1/CNIH4/ARRDC3	3
GO:0004843	thiol-dependent deubiquitinase	1/271	113/18367	0.814534635304873	0.890690312589476	PSMD14	1
GO:0101005	deubiquitinase activity	1/271	114/18367	0.817288065447986	0.891888395965551	PSMD14	1
GO:0005543	phospholipid binding	5/271	466/18367	0.820944956510916	0.894065559924844	GOLPH3/SCARB1/PIK3C2A/OSBP/PITPNB	5
GO:0004540	ribonuclease activity	1/271	116/18367	0.822673339051527	0.894137891736811	APEX1	1
GO:0008168	methyltransferase activity	2/271	214/18367	0.827006746585861	0.897035543675793	TRMT112/NTMT1	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	2/271	222/18367	0.842186113776903	0.906241046344397	ALAS1/NMT1	2
GO:0005085	guanyl-nucleotide exchange factor activity	2/271	223/18367	0.843996510297339	0.906241046344397	SH3BP5/EPS8L1	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/271	125/18367	0.845015480404255	0.906241046344397	HINT1	1
GO:0019783	ubiquitin-like protein-specific protease activity	1/271	125/18367	0.845015480404255	0.906241046344397	PSMD14	1
GO:0008242	omega peptidase activity	1/271	126/18367	0.847317903647893	0.906241046344397	PSMD14	1
GO:0016741	transferase activity, transferring one-carbon groups	2/271	225/18367	0.847561041751294	0.906241046344397	TRMT112/NTMT1	2
GO:0048018	receptor ligand activity	5/271	487/18367	0.848828146505663	0.906241046344397	CSH1/INHBA/CSH2/INHA/CSHL1	5
GO:0042826	histone deacetylase binding	1/271	127/18367	0.849586246836941	0.906241046344397	HNRNPD	1
GO:0140678	molecular function inhibitor activity	1/271	128/18367	0.851821012577467	0.906241046344397	RNH1	1
GO:0004519	endonuclease activity	1/271	129/18367	0.854022696090351	0.906241046344397	APEX1	1
GO:0016298	lipase activity	1/271	129/18367	0.854022696090351	0.906241046344397	ABHD12	1
GO:0030546	signaling receptor activator activity	5/271	495/18367	0.858465835133789	0.909162636421218	CSH1/INHBA/CSH2/INHA/CSHL1	5
GO:0016779	nucleotidyltransferase activity	1/271	132/18367	0.860434096953617	0.909456864756475	UGP2	1
GO:0005125	cytokine activity	2/271	235/18367	0.864299190427951	0.911750910686741	INHBA/INHA	2
GO:0043177	organic acid binding	1/271	135/18367	0.866564899140137	0.912352085591769	PAM	1
GO:0042393	histone binding	2/271	244/18367	0.877909705979507	0.91927545088589	NPM1/KMT2E	2
GO:0008194	UDP-glycosyltransferase activity	1/271	143/18367	0.881633276106674	0.91927545088589	MGAT1	1
GO:0004175	endopeptidase activity	4/271	430/18367	0.881770804984967	0.91927545088589	PAPPA2/HTRA1/FURIN/SEC11A	4
GO:0005178	integrin binding	1/271	144/18367	0.88339344852629	0.91927545088589	CALR	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	1/271	144/18367	0.88339344852629	0.91927545088589	APEX1	1
GO:0140375	immune receptor activity	1/271	144/18367	0.88339344852629	0.91927545088589	ACKR2	1
GO:0016746	acyltransferase activity	2/271	250/18367	0.886273787056925	0.91927545088589	ALAS1/NMT1	2
GO:0008528	G protein-coupled peptide receptor activity	1/271	147/18367	0.888519023161083	0.91927545088589	ACKR2	1
GO:0052689	carboxylic ester hydrolase activity	1/271	147/18367	0.888519023161083	0.91927545088589	ABHD12	1
GO:0015103	inorganic anion transmembrane transporter activity	1/271	152/18367	0.89656760269146	0.925634621347002	CLDN4	1
GO:0001653	peptide receptor activity	1/271	153/18367	0.898106454169396	0.925634621347002	ACKR2	1
GO:0015079	potassium ion transmembrane transporter activity	1/271	155/18367	0.901116059340685	0.926960688193668	ATP1B3	1
GO:0005096	GTPase activator activity	4/271	462/18367	0.912558333001466	0.936939662509139	SH3BP5/ERRFI1/EPS8L1/SYDE1	4
GO:0030695	GTPase regulator activity	4/271	488/18367	0.932107097289639	0.953371897988262	SH3BP5/ERRFI1/EPS8L1/SYDE1	4
GO:0060589	nucleoside-triphosphatase regulator activity	4/271	488/18367	0.932107097289639	0.953371897988262	SH3BP5/ERRFI1/EPS8L1/SYDE1	4
GO:0061630	ubiquitin protein ligase activity	2/271	304/18367	0.940910164080905	0.959349215861809	RBBP6/RNF10	2
GO:0008234	cysteine-type peptidase activity	1/271	190/18367	0.941517446050251	0.959349215861809	PSMD14	1
GO:0016758	hexosyltransferase activity	1/271	197/18367	0.947355458791308	0.9634133792493	MGAT1	1
GO:0061659	ubiquitin-like protein ligase activity	2/271	316/18367	0.949087529743734	0.9634133792493	RBBP6/RNF10	2
GO:0046873	metal ion transmembrane transporter activity	3/271	430/18367	0.954655067548041	0.967239974276546	ATP1B3/SLC38A2/SLC38A1	3
GO:0004518	nuclease activity	1/271	210/18367	0.956700285311682	0.967490138153543	APEX1	1
GO:0005539	glycosaminoglycan binding	1/271	230/18367	0.967952158465318	0.977032385092573	ENG	1
GO:0016757	glycosyltransferase activity	1/271	270/18367	0.982461593584284	0.989820856457575	MGAT1	1
GO:0140098	catalytic activity, acting on RNA	1/271	386/18367	0.996970054280839	0.999286773960653	APEX1	1
GO:0005216	ion channel activity	1/271	432/18367	0.998494541467743	0.999286773960653	CLDN4	1
GO:0015267	channel activity	1/271	480/18367	0.999275801875239	0.999286773960653	CLDN4	1
GO:0022803	passive transmembrane transporter activity	1/271	481/18367	0.999286773960653	0.999286773960653	CLDN4	1