ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 14/167 299/18367 6.26035522519227e-07 0.000135382565417443 JUND/FOS/NFKBIA/JUN/TAF7/NPM1/NR4A2/COMMD7/ID2/CHD4/RBPJ/MED4/PTPN2/CEBPB 14 GO:0140297 DNA-binding transcription factor binding 16/167 394/18367 6.47763470896855e-07 0.000135382565417443 JUND/FOS/NFKBIA/JUN/TAF7/NPM1/NR4A2/COMMD7/ID2/CHD4/RBPJ/MED4/TLE4/PTMA/PTPN2/CEBPB 16 GO:0003924 GTPase activity 13/167 337/18367 1.31256734284894e-05 0.00182884383103619 ARF6/RGS1/GSPT1/TUBA4A/RAB8A/RAP1A/MX1/ARL4C/GBP4/GBP1/RHOF/ARL5A/ARL4A 13 GO:0005525 GTP binding 13/167 377/18367 4.22991534038734e-05 0.00442026153070477 ARF6/IFI44L/GSPT1/TUBA4A/RAB8A/RAP1A/MX1/ARL4C/GBP4/GBP1/RHOF/ARL5A/ARL4A 13 GO:0019001 guanyl nucleotide binding 13/167 398/18367 7.34279636593191e-05 0.0051154814682659 ARF6/IFI44L/GSPT1/TUBA4A/RAB8A/RAP1A/MX1/ARL4C/GBP4/GBP1/RHOF/ARL5A/ARL4A 13 GO:0032561 guanyl ribonucleotide binding 13/167 398/18367 7.34279636593191e-05 0.0051154814682659 ARF6/IFI44L/GSPT1/TUBA4A/RAB8A/RAP1A/MX1/ARL4C/GBP4/GBP1/RHOF/ARL5A/ARL4A 13 GO:0045182 translation regulator activity 7/167 140/18367 0.000295444623945877 0.0176422646870538 EIF2AK2/GSPT1/RPS27L/EIF1AX/EIF4A2/EIF4A1/EIF4G2 7 GO:0090079 translation regulator activity, nucleic acid binding 6/167 108/18367 0.000459874856253873 0.0240284612392649 GSPT1/RPS27L/EIF1AX/EIF4A2/EIF4A1/EIF4G2 6 GO:0003725 double-stranded RNA binding 5/167 74/18367 0.000568361174315342 0.0263972189848681 VIM/EIF2AK2/ADAR/HNRNPU/EIF4A1 5 GO:0008135 translation factor activity, RNA binding 5/167 84/18367 0.00101274802827917 0.0411444486291519 GSPT1/EIF1AX/EIF4A2/EIF4A1/EIF4G2 5 GO:0070412 R-SMAD binding 3/167 23/18367 0.00114377080430539 0.0411444486291519 FOS/JUN/RGCC 3 GO:0003743 translation initiation factor activity 4/167 51/18367 0.00118118034342063 0.0411444486291519 EIF1AX/EIF4A2/EIF4A1/EIF4G2 4 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/167 25/18367 0.00146575253118813 0.0471295813874339 ZFP36L2/ZFP36/HNRNPA0 3 GO:0051059 NF-kappaB binding 3/167 29/18367 0.00226746690353399 0.0677000832626576 NFKBIA/NPM1/COMMD7 3 GO:0008330 protein tyrosine/threonine phosphatase activity 2/167 10/18367 0.00352503849687137 0.0920916307307647 DUSP1/DUSP2 2 GO:0050786 RAGE receptor binding 2/167 10/18367 0.00352503849687137 0.0920916307307647 S100A9/S100A8 2 GO:0051400 BH domain binding 2/167 11/18367 0.00428272252152665 0.0994543341110078 MCL1/BAX 2 GO:0070513 death domain binding 2/167 11/18367 0.00428272252152665 0.0994543341110078 MCL1/BAX 2 GO:0019003 GDP binding 4/167 75/18367 0.0048548522020247 0.102449352389545 ARF6/RAB8A/RAP1A/GBP1 4 GO:0035325 Toll-like receptor binding 2/167 12/18367 0.00510868313940389 0.102449352389545 S100A9/S100A8 2 GO:0061134 peptidase regulator activity 7/167 230/18367 0.00514697703392452 0.102449352389545 FN1/GAPDH/BST2/RPS27L/PEBP1/TNFAIP8/SERPINB9 7 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/167 40/18367 0.00569956127696218 0.105742433912068 RPS27L/TNFAIP8/SERPINB9 3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/167 13/18367 0.00600163122721869 0.105742433912068 DUSP1/DUSP2 2 GO:0031072 heat shock protein binding 5/167 129/18367 0.00651804167249603 0.105742433912068 ZFP36/BAX/DNAJB6/FKBP5/GBP1 5 GO:0001046 core promoter sequence-specific DNA binding 3/167 42/18367 0.00653553813934717 0.105742433912068 FOS/NPM1/CEBPB 3 GO:0035259 glucocorticoid receptor binding 2/167 14/18367 0.00696029521508881 0.105742433912068 NR4A2/CEBPB 2 GO:0036041 long-chain fatty acid binding 2/167 14/18367 0.00696029521508881 0.105742433912068 S100A9/S100A8 2 GO:0003779 actin binding 10/167 440/18367 0.00708322523812894 0.105742433912068 CXCR4/MYH9/TMSB4X/LSP1/ALDOA/COTL1/HNRNPU/TMOD3/GBP1/CAPG 10 GO:0042809 vitamin D receptor binding 2/167 15/18367 0.00798342087704032 0.114698033885525 TAF7/MED4 2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 10/167 450/18367 0.00823191630757356 0.114698033885525 JUND/FOS/JUNB/KLF6/JUN/FOSB/NR4A2/RBPJ/CEBPB/CSRNP1 10 GO:0001216 DNA-binding transcription activator activity 10/167 456/18367 0.00898704683660183 0.121180179925792 JUND/FOS/JUNB/KLF6/JUN/FOSB/NR4A2/RBPJ/CEBPB/CSRNP1 10 GO:0016922 nuclear receptor binding 5/167 144/18367 0.0102257664936569 0.133574074823393 JUND/TAF7/NR4A2/MED4/CEBPB 5 GO:0033549 MAP kinase phosphatase activity 2/167 18/18367 0.0114272814717238 0.144745565308501 DUSP1/DUSP2 2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/167 20/18367 0.0140232645510318 0.167477845209466 FOS/CEBPB 2 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/167 20/18367 0.0140232645510318 0.167477845209466 TAF7/HNRNPU 2 GO:0036002 pre-mRNA binding 3/167 59/18367 0.0165469566816396 0.185332619606799 HNRNPU/HNRNPA1/SRSF2 3 GO:0008320 protein transmembrane transporter activity 2/167 22/18367 0.0168484199642544 0.185332619606799 MCL1/TOMM20 2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/167 22/18367 0.0168484199642544 0.185332619606799 TNFAIP8/SERPINB9 2 GO:0047485 protein N-terminus binding 4/167 110/18367 0.0180789264558635 0.193769006629512 ARF6/NPM1/MORF4L1/RBPJ 4 GO:0019957 C-C chemokine binding 2/167 24/18367 0.019893702389071 0.207889189965792 CXCR4/ZFP36 2 GO:0035035 histone acetyltransferase binding 2/167 25/18367 0.0214961328114956 0.219155695492808 TAF7/CEBPB 2 GO:0019843 rRNA binding 3/167 68/18367 0.0240492338536643 0.23177018087559 NPM1/GTF3A/SBDS 3 GO:0004866 endopeptidase inhibitor activity 5/167 180/18367 0.0244658257457777 0.23177018087559 GAPDH/BST2/PEBP1/TNFAIP8/SERPINB9 5 GO:0022884 macromolecule transmembrane transporter activity 2/167 27/18367 0.0248551887801772 0.23177018087559 MCL1/TOMM20 2 GO:0051082 unfolded protein binding 4/167 122/18367 0.0253194143608149 0.23177018087559 NPM1/TOMM20/DNAJB6/CCT3 4 GO:0003735 structural constituent of ribosome 5/167 182/18367 0.0255058093786534 0.23177018087559 RPL39/RPL36A/RPS27L/RPS28/RPS10 5 GO:0048029 monosaccharide binding 3/167 71/18367 0.0268950964650433 0.239194687710385 ALDOA/SLC2A3/P4HA1 3 GO:0030414 peptidase inhibitor activity 5/167 187/18367 0.0282286519625362 0.24582451084042 GAPDH/BST2/PEBP1/TNFAIP8/SERPINB9 5 GO:0017022 myosin binding 3/167 74/18367 0.0299130570515511 0.253003341054918 CXCR4/VAMP2/RAB8A 3 GO:0046966 thyroid hormone receptor binding 2/167 30/18367 0.0302635575424543 0.253003341054918 TAF7/MED4 2 GO:0140318 protein transporter activity 2/167 31/18367 0.0321608709624232 0.255433498167731 MCL1/TOMM20 2 GO:0061135 endopeptidase regulator activity 5/167 194/18367 0.0323404708422187 0.255433498167731 GAPDH/BST2/PEBP1/TNFAIP8/SERPINB9 5 GO:0045296 cadherin binding 7/167 332/18367 0.0323875009638511 0.255433498167731 MYH9/LDHA/BZW1/ALDOA/TMOD3/EIF4G2/CAPG 7 GO:0071889 14-3-3 protein binding 2/167 32/18367 0.0341037857144264 0.259034754029603 DDIT4/ZFP36 2 GO:0002020 protease binding 4/167 135/18367 0.0348852509761372 0.259034754029603 FN1/TNFAIP3/CFLAR/SERPINB9 4 GO:0043177 organic acid binding 4/167 135/18367 0.0348852509761372 0.259034754029603 S100A9/S100A8/HBG1/P4HA1 4 GO:0046332 SMAD binding 3/167 79/18367 0.0353229210040367 0.259034754029603 FOS/JUN/RGCC 3 GO:0019956 chemokine binding 2/167 33/18367 0.0360913264718439 0.260106456297082 CXCR4/ZFP36 2 GO:0035198 miRNA binding 2/167 34/18367 0.0381225316860465 0.270088444826567 YBX1/HNRNPA1 2 GO:0019887 protein kinase regulator activity 5/167 204/18367 0.0388345037501452 0.270547042792678 NPM1/STK4/SOCS1/RGCC/DAZAP2 5 GO:0043394 proteoglycan binding 2/167 36/18367 0.0423121571775248 0.284692925502284 FN1/APOE 2 GO:0097718 disordered domain specific binding 2/167 36/18367 0.0423121571775248 0.284692925502284 FN1/GAPDH 2 GO:0016209 antioxidant activity 3/167 86/18367 0.043683419739862 0.284692925502284 S100A9/APOE/HBG1 3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/167 37/18367 0.0444687217499651 0.284692925502284 GAPDH/ALDH9A1 2 GO:0043531 ADP binding 2/167 37/18367 0.0444687217499651 0.284692925502284 MYH9/PGK1 2 GO:0003727 single-stranded RNA binding 3/167 87/18367 0.0449515145529921 0.284692925502284 HNRNPF/HNRNPU/HNRNPA1 3 GO:0048306 calcium-dependent protein binding 3/167 88/18367 0.0462378024215825 0.288468677794351 VAMP2/S100A9/S100A8 3 GO:0043021 ribonucleoprotein complex binding 4/167 149/18367 0.0472388588811112 0.290380044298595 NPM1/SRP9/SBDS/HNRNPU 4 GO:0005504 fatty acid binding 2/167 39/18367 0.0489008139265724 0.296239713352279 S100A9/S100A8 2 GO:0044183 protein folding chaperone 2/167 40/18367 0.0511745640660256 0.305585253994267 DNAJB6/CCT3 2 GO:0015631 tubulin binding 7/167 375/18367 0.0557784426463359 0.328385760931949 GAPDH/S100A9/S100A8/SBDS/MX1/ARL4C/ALDOA 7 GO:0016504 peptidase activator activity 2/167 43/18367 0.0582162314512786 0.337977565925479 FN1/RPS27L 2 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/167 44/18367 0.0606341098836592 0.347192574402322 GAPDH/ALDH9A1 2 GO:0019207 kinase regulator activity 5/167 233/18367 0.0619028051230435 0.34966719650584 NPM1/STK4/SOCS1/RGCC/DAZAP2 5 GO:0030295 protein kinase activator activity 3/167 101/18367 0.0645710860268954 0.352900738816058 STK4/RGCC/DAZAP2 3 GO:0061980 regulatory RNA binding 2/167 46/18367 0.0655709085985206 0.352900738816058 YBX1/HNRNPA1 2 GO:0140296 general transcription initiation factor binding 2/167 46/18367 0.0655709085985206 0.352900738816058 TAF7/HNRNPU 2 GO:0004725 protein tyrosine phosphatase activity 3/167 102/18367 0.0661015564366265 0.352900738816058 DUSP1/DUSP2/PTPN2 3 GO:0005200 structural constituent of cytoskeleton 3/167 103/18367 0.0676486194415141 0.352900738816058 VIM/TUBA4A/ACTG1 3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/167 47/18367 0.0680882231236112 0.352900738816058 DUSP1/DUSP2 2 GO:0043539 protein serine/threonine kinase activator activity 2/167 49/18367 0.0732167553163814 0.352900738816058 STK4/DAZAP2 2 GO:0033218 amide binding 7/167 400/18367 0.0732507704579859 0.352900738816058 NFKBIA/HLA-A/APOE/ITM2A/CRIP1/TOMM20/FKBP5 7 GO:0042277 peptide binding 6/167 321/18367 0.073285026766812 0.352900738816058 NFKBIA/HLA-A/APOE/ITM2A/CRIP1/TOMM20 6 GO:0019209 kinase activator activity 3/167 107/18367 0.074000280905208 0.352900738816058 STK4/RGCC/DAZAP2 3 GO:0051087 chaperone binding 3/167 107/18367 0.074000280905208 0.352900738816058 FN1/BAX/DNAJB6 3 GO:0005048 signal sequence binding 2/167 50/18367 0.0758264363870523 0.352900738816058 NFKBIA/TOMM20 2 GO:0051018 protein kinase A binding 2/167 51/18367 0.0784653884252957 0.352900738816058 PJA2/AKAP13 2 GO:0003712 transcription coregulator activity 8/167 489/18367 0.0785369745615039 0.352900738816058 BTG1/NPM1/BTG2/BCLAF1/MED4/TLE4/HNRNPU/SRSF2 8 GO:0017069 snRNA binding 2/167 53/18367 0.0838281545740843 0.352900738816058 HNRNPU/ISG20 2 GO:0004690 cyclic nucleotide-dependent protein kinase activity 1/167 10/18367 0.0873130242836005 0.352900738816058 AKAP13 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/167 10/18367 0.0873130242836005 0.352900738816058 PTPN2 1 GO:0004955 prostaglandin receptor activity 1/167 10/18367 0.0873130242836005 0.352900738816058 PTGER4 1 GO:0005031 tumor necrosis factor-activated receptor activity 1/167 10/18367 0.0873130242836005 0.352900738816058 TNFRSF18 1 GO:0005522 profilin binding 1/167 10/18367 0.0873130242836005 0.352900738816058 ACTG1 1 GO:0005528 FK506 binding 1/167 10/18367 0.0873130242836005 0.352900738816058 FKBP5 1 GO:0008097 5S rRNA binding 1/167 10/18367 0.0873130242836005 0.352900738816058 GTF3A 1 GO:0016868 intramolecular transferase activity, phosphotransferases 1/167 10/18367 0.0873130242836005 0.352900738816058 PGAM1 1 GO:0030957 Tat protein binding 1/167 10/18367 0.0873130242836005 0.352900738816058 NPM1 1 GO:0031720 haptoglobin binding 1/167 10/18367 0.0873130242836005 0.352900738816058 HBG1 1 GO:0034511 U3 snoRNA binding 1/167 10/18367 0.0873130242836005 0.352900738816058 ISG20 1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/167 10/18367 0.0873130242836005 0.352900738816058 CFLAR 1 GO:0098505 G-rich strand telomeric DNA binding 1/167 10/18367 0.0873130242836005 0.352900738816058 HNRNPA1 1 GO:0003714 transcription corepressor activity 4/167 187/18367 0.0913392243202795 0.352900738816058 BTG2/TLE4/HNRNPU/SRSF2 4 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/167 56/18367 0.0920736766409814 0.352900738816058 TNFAIP8/SERPINB9 2 GO:0051287 NAD binding 2/167 56/18367 0.0920736766409814 0.352900738816058 GAPDH/LDHA 2 GO:0004954 prostanoid receptor activity 1/167 11/18367 0.0956160544598076 0.352900738816058 PTGER4 1 GO:0005078 MAP-kinase scaffold activity 1/167 11/18367 0.0956160544598076 0.352900738816058 AKAP13 1 GO:0005536 glucose binding 1/167 11/18367 0.0956160544598076 0.352900738816058 SLC2A3 1 GO:0016832 aldehyde-lyase activity 1/167 11/18367 0.0956160544598076 0.352900738816058 ALDOA 1 GO:0031996 thioesterase binding 1/167 11/18367 0.0956160544598076 0.352900738816058 ARF6 1 GO:0042608 T cell receptor binding 1/167 11/18367 0.0956160544598076 0.352900738816058 HLA-A 1 GO:0047134 protein-disulfide reductase (NAD(P)) activity 1/167 11/18367 0.0956160544598076 0.352900738816058 PGK1 1 GO:0099186 structural constituent of postsynapse 1/167 11/18367 0.0956160544598076 0.352900738816058 ACTG1 1 GO:0008017 microtubule binding 5/167 271/18367 0.101649026776661 0.352900738816058 GAPDH/S100A9/S100A8/SBDS/MX1 5 GO:0003697 single-stranded DNA binding 3/167 123/18367 0.101871014398639 0.352900738816058 YBX1/HNRNPU/HNRNPA1 3 GO:0005527 macrolide binding 1/167 12/18367 0.103843997307118 0.352900738816058 FKBP5 1 GO:0008296 3'-5'-exodeoxyribonuclease activity 1/167 12/18367 0.103843997307118 0.352900738816058 ISG20 1 GO:0008429 phosphatidylethanolamine binding 1/167 12/18367 0.103843997307118 0.352900738816058 PEBP1 1 GO:0031543 peptidyl-proline dioxygenase activity 1/167 12/18367 0.103843997307118 0.352900738816058 P4HA1 1 GO:0043047 single-stranded telomeric DNA binding 1/167 12/18367 0.103843997307118 0.352900738816058 HNRNPA1 1 GO:0043422 protein kinase B binding 1/167 12/18367 0.103843997307118 0.352900738816058 SRSF5 1 GO:0061578 Lys63-specific deubiquitinase activity 1/167 12/18367 0.103843997307118 0.352900738816058 TNFAIP3 1 GO:0097677 STAT family protein binding 1/167 12/18367 0.103843997307118 0.352900738816058 PTPN2 1 GO:0043621 protein self-association 2/167 61/18367 0.106307206435533 0.354658838076955 VAMP2/TNFAIP3 2 GO:0003730 mRNA 3'-UTR binding 4/167 201/18367 0.111234543464236 0.354658838076955 ZFP36L2/ZFP36/HNRNPA0/HNRNPU 4 GO:0004000 adenosine deaminase activity 1/167 13/18367 0.111997527813775 0.354658838076955 ADAR 1 GO:0005035 death receptor activity 1/167 13/18367 0.111997527813775 0.354658838076955 TNFRSF18 1 GO:0008494 translation activator activity 1/167 13/18367 0.111997527813775 0.354658838076955 RPS27L 1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/167 13/18367 0.111997527813775 0.354658838076955 PGK1 1 GO:0031994 insulin-like growth factor I binding 1/167 13/18367 0.111997527813775 0.354658838076955 IGFBP2 1 GO:0034236 protein kinase A catalytic subunit binding 1/167 13/18367 0.111997527813775 0.354658838076955 PJA2 1 GO:0072542 protein phosphatase activator activity 1/167 13/18367 0.111997527813775 0.354658838076955 PPP1R15A 1 GO:0005344 oxygen carrier activity 1/167 14/18367 0.120077314936751 0.360132821451127 HBG1 1 GO:0032977 membrane insertase activity 1/167 14/18367 0.120077314936751 0.360132821451127 EMC4 1 GO:0043023 ribosomal large subunit binding 1/167 14/18367 0.120077314936751 0.360132821451127 NPM1 1 GO:0071837 HMG box domain binding 1/167 14/18367 0.120077314936751 0.360132821451127 JUN 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/167 15/18367 0.128084021655302 0.360132821451127 ALDH9A1 1 GO:0004953 icosanoid receptor activity 1/167 15/18367 0.128084021655302 0.360132821451127 PTGER4 1 GO:0019215 intermediate filament binding 1/167 15/18367 0.128084021655302 0.360132821451127 VIM 1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process 1/167 15/18367 0.128084021655302 0.360132821451127 CFLAR 1 GO:0098847 sequence-specific single stranded DNA binding 1/167 15/18367 0.128084021655302 0.360132821451127 HNRNPA1 1 GO:0005096 GTPase activator activity 7/167 462/18367 0.12902666834814 0.360132821451127 JUN/RGS1/SMAP2/RAP1A/RHOF/AKAP13/ARHGAP30 7 GO:0019955 cytokine binding 3/167 139/18367 0.133239700639444 0.360132821451127 CXCR4/ZFP36/GBP1 3 GO:0001098 basal transcription machinery binding 2/167 70/18367 0.133244751079453 0.360132821451127 TAF7/HNRNPU 2 GO:0001099 basal RNA polymerase II transcription machinery binding 2/167 70/18367 0.133244751079453 0.360132821451127 TAF7/HNRNPU 2 GO:0004860 protein kinase inhibitor activity 2/167 70/18367 0.133244751079453 0.360132821451127 NPM1/SOCS1 2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/167 16/18367 0.136018305024066 0.360132821451127 ALDH9A1 1 GO:0005159 insulin-like growth factor receptor binding 1/167 16/18367 0.136018305024066 0.360132821451127 SOCS1 1 GO:0005521 lamin binding 1/167 16/18367 0.136018305024066 0.360132821451127 BNIP3L 1 GO:0005523 tropomyosin binding 1/167 16/18367 0.136018305024066 0.360132821451127 TMOD3 1 GO:0008191 metalloendopeptidase inhibitor activity 1/167 16/18367 0.136018305024066 0.360132821451127 BST2 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/167 16/18367 0.136018305024066 0.360132821451127 AOC1 1 GO:0035497 cAMP response element binding 1/167 16/18367 0.136018305024066 0.360132821451127 JUN 1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity 1/167 16/18367 0.136018305024066 0.360132821451127 SOCS1 1 GO:1990404 protein ADP-ribosylase activity 1/167 16/18367 0.136018305024066 0.360132821451127 PARP8 1 GO:0033293 monocarboxylic acid binding 2/167 73/18367 0.142539529118476 0.360132821451127 S100A9/S100A8 2 GO:0070063 RNA polymerase binding 2/167 73/18367 0.142539529118476 0.360132821451127 ZFP36/HNRNPU 2 GO:0106306 protein serine phosphatase activity 2/167 73/18367 0.142539529118476 0.360132821451127 DUSP1/DUSP2 2 GO:0106307 protein threonine phosphatase activity 2/167 73/18367 0.142539529118476 0.360132821451127 DUSP1/DUSP2 2 GO:0140104 molecular carrier activity 2/167 73/18367 0.142539529118476 0.360132821451127 HBG1/EMC4 2 GO:0005178 integrin binding 3/167 144/18367 0.143661329838525 0.360132821451127 FN1/MYH9/PTPN2 3 GO:0008308 voltage-gated anion channel activity 1/167 17/18367 0.14388081622569 0.360132821451127 VDAC3 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/167 17/18367 0.14388081622569 0.360132821451127 RPS27L 1 GO:0031489 myosin V binding 1/167 17/18367 0.14388081622569 0.360132821451127 RAB8A 1 GO:0043024 ribosomal small subunit binding 1/167 17/18367 0.14388081622569 0.360132821451127 NPM1 1 GO:0043395 heparan sulfate proteoglycan binding 1/167 17/18367 0.14388081622569 0.360132821451127 APOE 1 GO:0046965 retinoid X receptor binding 1/167 17/18367 0.14388081622569 0.360132821451127 NR4A2 1 GO:0019210 kinase inhibitor activity 2/167 74/18367 0.145668042231447 0.3602913707263 NPM1/SOCS1 2 GO:0019905 syntaxin binding 2/167 74/18367 0.145668042231447 0.3602913707263 VAMP2/PTPN2 2 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/167 18/18367 0.151672200622982 0.364361953220726 DAZAP2 1 GO:0048038 quinone binding 1/167 18/18367 0.151672200622982 0.364361953220726 AOC1 1 GO:0098641 cadherin binding involved in cell-cell adhesion 1/167 18/18367 0.151672200622982 0.364361953220726 TMOD3 1 GO:0098918 structural constituent of synapse 1/167 18/18367 0.151672200622982 0.364361953220726 ACTG1 1 GO:0140597 protein carrier activity 1/167 18/18367 0.151672200622982 0.364361953220726 EMC4 1 GO:0003724 RNA helicase activity 2/167 77/18367 0.155137043408102 0.369630385800105 EIF4A2/EIF4A1 2 GO:0140677 molecular function activator activity 3/167 150/18367 0.156510129209101 0.369630385800105 APOE/CFLAR/DNAJB6 3 GO:0030695 GTPase regulator activity 7/167 488/18367 0.157402413091911 0.369630385800105 JUN/RGS1/SMAP2/RAP1A/RHOF/AKAP13/ARHGAP30 7 GO:0060589 nucleoside-triphosphatase regulator activity 7/167 488/18367 0.157402413091911 0.369630385800105 JUN/RGS1/SMAP2/RAP1A/RHOF/AKAP13/ARHGAP30 7 GO:0030971 receptor tyrosine kinase binding 2/167 78/18367 0.158319513863493 0.369707021200783 PTPN2/DAZAP2 2 GO:0000339 RNA cap binding 1/167 19/18367 0.159393097810619 0.37014619380466 EIF4A1 1 GO:0044389 ubiquitin-like protein ligase binding 5/167 316/18367 0.161477075412556 0.37095026579427 CXCR4/NFKBIA/JUN/CEBPB/ACTG1 5 GO:0008186 ATP-dependent activity, acting on RNA 2/167 79/18367 0.161514230561141 0.37095026579427 EIF4A2/EIF4A1 2 GO:0016505 peptidase activator activity involved in apoptotic process 1/167 20/18367 0.167044141666387 0.373392787254277 RPS27L 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/167 20/18367 0.167044141666387 0.373392787254277 AOC1 1 GO:0019211 phosphatase activator activity 1/167 20/18367 0.167044141666387 0.373392787254277 PPP1R15A 1 GO:0031418 L-ascorbic acid binding 1/167 20/18367 0.167044141666387 0.373392787254277 P4HA1 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/167 20/18367 0.167044141666387 0.373392787254277 SOCS1 1 GO:0004386 helicase activity 3/167 156/18367 0.169701232692513 0.377314442901438 EIF4A2/CHD4/EIF4A1 3 GO:0005123 death receptor binding 1/167 21/18367 0.174625960401968 0.38417711288433 CFLAR 1 GO:0140416 transcription regulator inhibitor activity 1/167 21/18367 0.174625960401968 0.38417711288433 ID2 1 GO:0001540 amyloid-beta binding 2/167 84/18367 0.177654917485647 0.38469069060248 APOE/ITM2A 2 GO:0046982 protein heterodimerization activity 5/167 328/18367 0.179434455673111 0.38469069060248 TAF7/MCL1/NR4A2/BAX/CEBPB 5 GO:0005355 glucose transmembrane transporter activity 1/167 22/18367 0.182139176613288 0.38469069060248 SLC2A3 1 GO:0015149 hexose transmembrane transporter activity 1/167 22/18367 0.182139176613288 0.38469069060248 SLC2A3 1 GO:0017075 syntaxin-1 binding 1/167 22/18367 0.182139176613288 0.38469069060248 VAMP2 1 GO:0070034 telomerase RNA binding 1/167 22/18367 0.182139176613288 0.38469069060248 HNRNPU 1 GO:0120020 cholesterol transfer activity 1/167 22/18367 0.182139176613288 0.38469069060248 APOE 1 GO:0003950 NAD+ ADP-ribosyltransferase activity 1/167 23/18367 0.189584407330409 0.38469069060248 PARP8 1 GO:0004529 exodeoxyribonuclease activity 1/167 23/18367 0.189584407330409 0.38469069060248 ISG20 1 GO:0005212 structural constituent of eye lens 1/167 23/18367 0.189584407330409 0.38469069060248 VIM 1 GO:0008143 poly(A) binding 1/167 23/18367 0.189584407330409 0.38469069060248 HNRNPU 1 GO:0016493 C-C chemokine receptor activity 1/167 23/18367 0.189584407330409 0.38469069060248 CXCR4 1 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/167 23/18367 0.189584407330409 0.38469069060248 ISG20 1 GO:0050750 low-density lipoprotein particle receptor binding 1/167 23/18367 0.189584407330409 0.38469069060248 APOE 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/167 23/18367 0.189584407330409 0.38469069060248 TNFAIP3 1 GO:0120015 sterol transfer activity 1/167 23/18367 0.189584407330409 0.38469069060248 APOE 1 GO:0008201 heparin binding 3/167 166/18367 0.192356860081224 0.388350124433968 FN1/AOC1/APOE 3 GO:0019888 protein phosphatase regulator activity 2/167 89/18367 0.194032698989619 0.388350124433968 PPP1R15A/EIF2AK2 2 GO:0001965 G-protein alpha-subunit binding 1/167 24/18367 0.196962264066989 0.388350124433968 RGS1 1 GO:0015145 monosaccharide transmembrane transporter activity 1/167 24/18367 0.196962264066989 0.388350124433968 SLC2A3 1 GO:0016769 transferase activity, transferring nitrogenous groups 1/167 24/18367 0.196962264066989 0.388350124433968 GAPDH 1 GO:0043495 protein-membrane adaptor activity 1/167 24/18367 0.196962264066989 0.388350124433968 MYH9 1 GO:0043130 ubiquitin binding 2/167 92/18367 0.203950980366333 0.395306766200777 CXCR4/TNFAIP3 2 GO:0008327 methyl-CpG binding 1/167 25/18367 0.204273352869301 0.395306766200777 ERH 1 GO:0034237 protein kinase A regulatory subunit binding 1/167 25/18367 0.204273352869301 0.395306766200777 PJA2 1 GO:0051019 mitogen-activated protein kinase binding 1/167 25/18367 0.204273352869301 0.395306766200777 DUSP1 1 GO:0004721 phosphoprotein phosphatase activity 3/167 174/18367 0.210997910058526 0.40188472129316 DUSP1/DUSP2/PTPN2 3 GO:0001637 G protein-coupled chemoattractant receptor activity 1/167 26/18367 0.211518274364821 0.40188472129316 CXCR4 1 GO:0004950 chemokine receptor activity 1/167 26/18367 0.211518274364821 0.40188472129316 CXCR4 1 GO:0042974 retinoic acid receptor binding 1/167 26/18367 0.211518274364821 0.40188472129316 NR4A2 1 GO:0031406 carboxylic acid binding 3/167 176/18367 0.215720086406106 0.404493835189118 S100A9/S100A8/P4HA1 3 GO:0001671 ATPase activator activity 1/167 27/18367 0.218697623810384 0.404493835189118 DNAJB6 1 GO:0008139 nuclear localization sequence binding 1/167 27/18367 0.218697623810384 0.404493835189118 NFKBIA 1 GO:0016866 intramolecular transferase activity 1/167 27/18367 0.218697623810384 0.404493835189118 PGAM1 1 GO:0030507 spectrin binding 1/167 27/18367 0.218697623810384 0.404493835189118 GBP1 1 GO:0051119 sugar transmembrane transporter activity 1/167 27/18367 0.218697623810384 0.404493835189118 SLC2A3 1 GO:1901681 sulfur compound binding 4/167 265/18367 0.22177078550498 0.40685091507106 FN1/AOC1/CHST12/APOE 4 GO:0004722 protein serine/threonine phosphatase activity 2/167 98/18367 0.223943950502194 0.40685091507106 DUSP1/DUSP2 2 GO:0004867 serine-type endopeptidase inhibitor activity 2/167 98/18367 0.223943950502194 0.40685091507106 PEBP1/SERPINB9 2 GO:0003785 actin monomer binding 1/167 28/18367 0.225811991139919 0.40685091507106 TMSB4X 1 GO:0008187 poly-pyrimidine tract binding 1/167 28/18367 0.225811991139919 0.40685091507106 HNRNPU 1 GO:0070325 lipoprotein particle receptor binding 1/167 28/18367 0.225811991139919 0.40685091507106 APOE 1 GO:0005520 insulin-like growth factor binding 1/167 29/18367 0.232861961011756 0.415106003267209 IGFBP2 1 GO:0070717 poly-purine tract binding 1/167 29/18367 0.232861961011756 0.415106003267209 HNRNPU 1 GO:0030246 carbohydrate binding 4/167 271/18367 0.23337299226745 0.415106003267209 CD69/ALDOA/SLC2A3/P4HA1 4 GO:0022829 wide pore channel activity 1/167 30/18367 0.239848112855526 0.423901618464826 VDAC3 1 GO:0031490 chromatin DNA binding 2/167 103/18367 0.240717299910284 0.423901618464826 CHD4/HNRNPU 2 GO:0000146 microfilament motor activity 1/167 31/18367 0.246771020918629 0.423901618464826 MYH9 1 GO:0008157 protein phosphatase 1 binding 1/167 31/18367 0.246771020918629 0.423901618464826 PPP1R15A 1 GO:0071813 lipoprotein particle binding 1/167 31/18367 0.246771020918629 0.423901618464826 APOE 1 GO:0071814 protein-lipid complex binding 1/167 31/18367 0.246771020918629 0.423901618464826 APOE 1 GO:0090482 vitamin transmembrane transporter activity 1/167 31/18367 0.246771020918629 0.423901618464826 SLC2A3 1 GO:0008022 protein C-terminus binding 3/167 189/18367 0.246911612864718 0.423901618464826 FN1/VAMP2/TNFAIP3 3 GO:1990782 protein tyrosine kinase binding 2/167 105/18367 0.247444963888559 0.423901618464826 PTPN2/DAZAP2 2 GO:0030515 snoRNA binding 1/167 32/18367 0.253631254312313 0.428415065787455 ISG20 1 GO:0050699 WW domain binding 1/167 32/18367 0.253631254312313 0.428415065787455 DAZAP2 1 GO:0140658 ATP-dependent chromatin remodeler activity 1/167 32/18367 0.253631254312313 0.428415065787455 CHD4 1 GO:0019208 phosphatase regulator activity 2/167 107/18367 0.254179273481552 0.428415065787455 PPP1R15A/EIF2AK2 2 GO:0005154 epidermal growth factor receptor binding 1/167 33/18367 0.260429377057327 0.435437918439852 AREG 1 GO:0019239 deaminase activity 1/167 33/18367 0.260429377057327 0.435437918439852 ADAR 1 GO:0000149 SNARE binding 2/167 110/18367 0.264287906950296 0.438382321846125 VAMP2/PTPN2 2 GO:0008047 enzyme activator activity 2/167 110/18367 0.264287906950296 0.438382321846125 APOE/CFLAR 2 GO:0032182 ubiquitin-like protein binding 2/167 111/18367 0.267658195988014 0.442217889023675 CXCR4/TNFAIP3 2 GO:0051020 GTPase binding 4/167 291/18367 0.273013748767766 0.44744609965945 RAB8A/RAP1A/YBX1/AKAP13 4 GO:0000175 3'-5'-exoribonuclease activity 1/167 35/18367 0.273841521503015 0.44744609965945 ISG20 1 GO:0005516 calmodulin binding 3/167 201/18367 0.276285820712192 0.44744609965945 VAMP2/RGS1/MYH9 3 GO:0005484 SNAP receptor activity 1/167 36/18367 0.280456646198028 0.44744609965945 VAMP2 1 GO:0015248 sterol transporter activity 1/167 36/18367 0.280456646198028 0.44744609965945 APOE 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/167 36/18367 0.280456646198028 0.44744609965945 ADAR 1 GO:0042162 telomeric DNA binding 1/167 36/18367 0.280456646198028 0.44744609965945 HNRNPA1 1 GO:0042605 peptide antigen binding 1/167 36/18367 0.280456646198028 0.44744609965945 HLA-A 1 GO:0061631 ubiquitin conjugating enzyme activity 1/167 36/18367 0.280456646198028 0.44744609965945 UBE2S 1 GO:0031625 ubiquitin protein ligase binding 4/167 297/18367 0.285136538843245 0.453182787971394 CXCR4/NFKBIA/JUN/ACTG1 4 GO:0015035 protein-disulfide reductase activity 1/167 37/18367 0.287011866321586 0.454435455009178 PGK1 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/167 38/18367 0.293507721112873 0.459498979120528 FKBP5 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/167 38/18367 0.293507721112873 0.459498979120528 TAF7 1 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters 1/167 38/18367 0.293507721112873 0.459498979120528 ISG20 1 GO:0019825 oxygen binding 1/167 39/18367 0.299944744986197 0.465611670712318 HBG1 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/167 39/18367 0.299944744986197 0.465611670712318 UBE2S 1 GO:0005179 hormone activity 2/167 122/18367 0.304666694974891 0.465611670712318 CGA/METRNL 2 GO:0003925 G protein activity 1/167 40/18367 0.306323467573894 0.465611670712318 RAP1A 1 GO:0004532 exoribonuclease activity 1/167 40/18367 0.306323467573894 0.465611670712318 ISG20 1 GO:0015144 carbohydrate transmembrane transporter activity 1/167 40/18367 0.306323467573894 0.465611670712318 SLC2A3 1 GO:0031492 nucleosomal DNA binding 1/167 40/18367 0.306323467573894 0.465611670712318 CHD4 1 GO:0043014 alpha-tubulin binding 1/167 40/18367 0.306323467573894 0.465611670712318 ARL4C 1 GO:0016859 cis-trans isomerase activity 1/167 41/18367 0.312644413768861 0.473497699113709 FKBP5 1 GO:0051015 actin filament binding 3/167 217/18367 0.31593244410125 0.476750042001164 MYH9/COTL1/CAPG 3 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/167 42/18367 0.318908103766711 0.477790635750843 NDUFB8 1 GO:0015036 disulfide oxidoreductase activity 1/167 42/18367 0.318908103766711 0.477790635750843 PGK1 1 GO:0042826 histone deacetylase binding 2/167 127/18367 0.321393601798558 0.479794734113561 CHD4/CEBPB 2 GO:0030544 Hsp70 protein binding 1/167 43/18367 0.325115053107554 0.481908128365098 BAX 1 GO:0050136 NADH dehydrogenase (quinone) activity 1/167 43/18367 0.325115053107554 0.481908128365098 NDUFB8 1 GO:0005085 guanyl-nucleotide exchange factor activity 3/167 223/18367 0.330854560269347 0.486030070295215 RAP1A/RHOF/AKAP13 3 GO:0051879 Hsp90 protein binding 1/167 44/18367 0.331265772717412 0.486030070295215 GBP1 1 GO:0017124 SH3 domain binding 2/167 130/18367 0.331384138837647 0.486030070295215 OSTF1/QKI 2 GO:0003954 NADH dehydrogenase activity 1/167 45/18367 0.337360768949263 0.486264832485489 NDUFB8 1 GO:0003955 NAD(P)H dehydrogenase (quinone) activity 1/167 45/18367 0.337360768949263 0.486264832485489 NDUFB8 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/167 45/18367 0.337360768949263 0.486264832485489 EIF2AK2 1 GO:0048156 tau protein binding 1/167 45/18367 0.337360768949263 0.486264832485489 APOE 1 GO:0140223 general transcription initiation factor activity 1/167 45/18367 0.337360768949263 0.486264832485489 TAF7 1 GO:0044325 transmembrane transporter binding 2/167 133/18367 0.341333818328772 0.490300811207652 VAMP2/ID2 2 GO:0005539 glycosaminoglycan binding 3/167 230/18367 0.34825427928681 0.498528386102351 FN1/AOC1/APOE 3 GO:0015026 coreceptor activity 1/167 48/18367 0.355316413162741 0.505177757489884 CXCR4 1 GO:0120013 lipid transfer activity 1/167 48/18367 0.355316413162741 0.505177757489884 APOE 1 GO:0016763 pentosyltransferase activity 1/167 49/18367 0.361193489367874 0.508346392443675 PARP8 1 GO:0032813 tumor necrosis factor receptor superfamily binding 1/167 49/18367 0.361193489367874 0.508346392443675 CFLAR 1 GO:0098632 cell-cell adhesion mediator activity 1/167 49/18367 0.361193489367874 0.508346392443675 TMOD3 1 GO:0000993 RNA polymerase II complex binding 1/167 50/18367 0.367017306775646 0.513942748598795 HNRNPU 1 GO:0019838 growth factor binding 2/167 141/18367 0.367628903902009 0.513942748598795 DUSP1/IGFBP2 2 GO:0004601 peroxidase activity 1/167 51/18367 0.372788345142653 0.518740850526727 HBG1 1 GO:0004879 nuclear receptor activity 1/167 52/18367 0.378507079929788 0.518740850526727 NR4A2 1 GO:0008146 sulfotransferase activity 1/167 52/18367 0.378507079929788 0.518740850526727 CHST12 1 GO:0016830 carbon-carbon lyase activity 1/167 52/18367 0.378507079929788 0.518740850526727 ALDOA 1 GO:0031593 polyubiquitin modification-dependent protein binding 1/167 52/18367 0.378507079929788 0.518740850526727 TNFAIP3 1 GO:0098531 ligand-activated transcription factor activity 1/167 52/18367 0.378507079929788 0.518740850526727 NR4A2 1 GO:0042393 histone binding 3/167 244/18367 0.382894883514884 0.523039416043207 TAF7/NPM1/NASP 3 GO:0050661 NADP binding 1/167 53/18367 0.384173982340475 0.523077278887031 GAPDH 1 GO:0008408 3'-5' exonuclease activity 1/167 54/18367 0.389789519358556 0.527288087675975 ISG20 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/167 54/18367 0.389789519358556 0.527288087675975 P4HA1 1 GO:0005080 protein kinase C binding 1/167 55/18367 0.395354153785855 0.531376322451728 SRSF2 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/167 55/18367 0.395354153785855 0.531376322451728 HBG1 1 GO:0030374 nuclear receptor coactivator activity 1/167 56/18367 0.400868344279398 0.53706079457945 MED4 1 GO:0004536 deoxyribonuclease activity 1/167 57/18367 0.406332545388313 0.53749051889973 ISG20 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/167 57/18367 0.406332545388313 0.53749051889973 NDUFB8 1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/167 57/18367 0.406332545388313 0.53749051889973 PGK1 1 GO:0043175 RNA polymerase core enzyme binding 1/167 57/18367 0.406332545388313 0.53749051889973 HNRNPU 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/167 59/18367 0.417112777328362 0.547913830164762 ISG20 1 GO:0098631 cell adhesion mediator activity 1/167 59/18367 0.417112777328362 0.547913830164762 TMOD3 1 GO:0005543 phospholipid binding 5/167 466/18367 0.41814476512574 0.547913830164762 VAMP2/APOE/PEBP1/BIN2/CAPG 5 GO:0031267 small GTPase binding 3/167 259/18367 0.419546686694654 0.548032859494892 RAB8A/RAP1A/AKAP13 3 GO:0016853 isomerase activity 2/167 158/18367 0.422049288512434 0.549584431770085 PGAM1/FKBP5 2 GO:0005507 copper ion binding 1/167 61/18367 0.427698405222599 0.554268987514408 AOC1 1 GO:0140030 modification-dependent protein binding 2/167 160/18367 0.428298763079315 0.554268987514408 TAF7/TNFAIP3 2 GO:1990841 promoter-specific chromatin binding 1/167 62/18367 0.432919336410615 0.558519390801349 HNRNPU 1 GO:0016887 ATP hydrolysis activity 3/167 272/18367 0.450729328637629 0.579707259601628 EIF4A2/CHD4/EIF4A1 3 GO:0043022 ribosome binding 1/167 66/18367 0.453333846770455 0.581268551994019 SBDS 1 GO:0016791 phosphatase activity 3/167 275/18367 0.457832005684594 0.584081437394167 DUSP1/DUSP2/PTPN2 3 GO:0097110 scaffold protein binding 1/167 67/18367 0.458322276232743 0.584081437394167 VIM 1 GO:0003823 antigen binding 2/167 171/18367 0.462019694342905 0.586802910250048 HLA-A/CD48 2 GO:0016782 transferase activity, transferring sulphur-containing groups 1/167 68/18367 0.463265455460565 0.586802910250048 CHST12 1 GO:0004674 protein serine/threonine kinase activity 4/167 386/18367 0.467102249209169 0.589435136302758 STK17B/EIF2AK2/STK4/AKAP13 4 GO:0005518 collagen binding 1/167 69/18367 0.468163792470133 0.589435136302758 FN1 1 GO:0031491 nucleosome binding 1/167 71/18367 0.477827553647248 0.59979554782147 CHD4 1 GO:0003678 DNA helicase activity 1/167 72/18367 0.482593775692553 0.602161785789515 CHD4 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/167 72/18367 0.482593775692553 0.602161785789515 NDUFB8 1 GO:0035064 methylated histone binding 1/167 73/18367 0.487316751339416 0.604446296913578 TAF7 1 GO:0140034 methylation-dependent protein binding 1/167 73/18367 0.487316751339416 0.604446296913578 TAF7 1 GO:0015399 primary active transmembrane transporter activity 2/167 181/18367 0.491653262851988 0.608020899029973 TOMM20/NDUFB8 2 GO:0001618 virus receptor activity 1/167 76/18367 0.501230082980267 0.618035913527291 CXCR4 1 GO:0140272 exogenous protein binding 1/167 77/18367 0.505783938764111 0.620744278348853 CXCR4 1 GO:0030674 protein-macromolecule adaptor activity 3/167 296/18367 0.506396648126696 0.620744278348853 VAMP2/MYH9/AKAP13 3 GO:0001221 transcription coregulator binding 1/167 78/18367 0.51029646376282 0.623695677932336 CHD4 1 GO:0008234 cysteine-type peptidase activity 2/167 190/18367 0.517436227101773 0.630578259266884 TNFAIP3/CFLAR 2 GO:0004527 exonuclease activity 1/167 80/18367 0.519199009576015 0.630887168612716 ISG20 1 GO:0035591 signaling adaptor activity 1/167 81/18367 0.5235897661463 0.634378325359865 AKAP13 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/167 82/18367 0.527940663502396 0.637801148393068 CAPG 1 GO:0008013 beta-catenin binding 1/167 85/18367 0.540757780995125 0.651402744829863 NR4A2 1 GO:0005253 anion channel activity 1/167 87/18367 0.549109738596747 0.659562846935174 VDAC3 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/167 88/18367 0.55322892205705 0.662606559942255 NDUFB8 1 GO:0051117 ATPase binding 1/167 89/18367 0.55731069731918 0.665588204226907 CHMP4A 1 GO:0051213 dioxygenase activity 1/167 92/18367 0.569334935722939 0.67801140493501 P4HA1 1 GO:0004896 cytokine receptor activity 1/167 97/18367 0.58865809787563 0.699031491227311 CXCR4 1 GO:0140097 catalytic activity, acting on DNA 2/167 229/18367 0.618812936078102 0.73275866085169 CHD4/ISG20 2 GO:1902936 phosphatidylinositol bisphosphate binding 1/167 107/18367 0.624756549074749 0.737706885630636 CAPG 1 GO:0042626 ATPase-coupled transmembrane transporter activity 1/167 109/18367 0.631589056940251 0.743673875495845 TOMM20 1 GO:0008094 ATP-dependent activity, acting on DNA 1/167 111/18367 0.638297888591017 0.748074897148016 CHD4 1 GO:0106310 protein serine kinase activity 3/167 360/18367 0.638906072444597 0.748074897148016 STK17B/EIF2AK2/STK4 3 GO:0004843 thiol-dependent deubiquitinase 1/167 113/18367 0.644885269465042 0.752555705471608 TNFAIP3 1 GO:0003774 cytoskeletal motor activity 1/167 114/18367 0.64813410040617 0.752555705471608 MYH9 1 GO:0101005 deubiquitinase activity 1/167 114/18367 0.64813410040617 0.752555705471608 TNFAIP3 1 GO:0042578 phosphoric ester hydrolase activity 3/167 366/18367 0.649980902526923 0.752609466083805 DUSP1/DUSP2/PTPN2 3 GO:0004540 ribonuclease activity 1/167 116/18367 0.654543390928851 0.754735102855518 ISG20 1 GO:0060090 molecular adaptor activity 3/167 369/18367 0.655427852479792 0.754735102855518 VAMP2/MYH9/AKAP13 3 GO:0004197 cysteine-type endopeptidase activity 1/167 119/18367 0.663940368945691 0.762437017085986 CFLAR 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/167 124/18367 0.679040660720115 0.771949628535049 EIF2AK2 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/167 124/18367 0.679040660720115 0.771949628535049 LDHA 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/167 125/18367 0.681978785461645 0.771949628535049 ADAR 1 GO:0019783 ubiquitin-like protein-specific protease activity 1/167 125/18367 0.681978785461645 0.771949628535049 TNFAIP3 1 GO:0008242 omega peptidase activity 1/167 126/18367 0.684890173622368 0.771949628535049 TNFAIP3 1 GO:0009055 electron transfer activity 1/167 126/18367 0.684890173622368 0.771949628535049 NDUFB8 1 GO:0140098 catalytic activity, acting on RNA 3/167 386/18367 0.685151464561013 0.771949628535049 EIF4A2/ISG20/EIF4A1 3 GO:0140678 molecular function inhibitor activity 1/167 128/18367 0.690633705415919 0.774621382669705 ID2 1 GO:0003713 transcription coactivator activity 2/167 262/18367 0.691229128554546 0.774621382669705 NPM1/MED4 2 GO:0004713 protein tyrosine kinase activity 1/167 136/18367 0.712585688535408 0.794295514154135 EIF2AK2 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/167 136/18367 0.712585688535408 0.794295514154135 LDHA 1 GO:0020037 heme binding 1/167 139/18367 0.720412320666893 0.800883909677556 HBG1 1 GO:0070851 growth factor receptor binding 1/167 141/18367 0.725512005298875 0.804413841418912 AREG 1 GO:0019199 transmembrane receptor protein kinase activity 1/167 143/18367 0.730519218469995 0.807822839472111 EIF2AK2 1 GO:0140375 immune receptor activity 1/167 144/18367 0.732988670320056 0.808414945102331 CXCR4 1 GO:0008528 G protein-coupled peptide receptor activity 1/167 147/18367 0.74026286794661 0.814289154741271 CXCR4 1 GO:0019842 vitamin binding 1/167 148/18367 0.742643554063675 0.814763794222089 P4HA1 1 GO:0046906 tetrapyrrole binding 1/167 149/18367 0.74500254887521 0.815212213167115 HBG1 1 GO:0019903 protein phosphatase binding 1/167 150/18367 0.747340048838864 0.81563483136983 PPP1R15A 1 GO:0005506 iron ion binding 1/167 151/18367 0.749656248643657 0.815892874319422 P4HA1 1 GO:0015103 inorganic anion transmembrane transporter activity 1/167 152/18367 0.75195134122581 0.815892874319422 VDAC3 1 GO:0001653 peptide receptor activity 1/167 153/18367 0.754225517784432 0.815892874319422 CXCR4 1 GO:0005319 lipid transporter activity 1/167 154/18367 0.756478967797059 0.815892874319422 APOE 1 GO:0004842 ubiquitin-protein transferase activity 3/167 433/18367 0.757335969463961 0.815892874319422 TNFAIP3/UBE2S/PJA2 3 GO:0008083 growth factor activity 1/167 162/18367 0.773782593506217 0.831468185310023 AREG 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 2/167 310/18367 0.776063467567309 0.831780844725987 JUN/CEBPB 2 GO:0001217 DNA-binding transcription repressor activity 2/167 313/18367 0.780626068651258 0.834004747872947 JUN/CEBPB 2 GO:0008509 anion transmembrane transporter activity 2/167 314/18367 0.782128854464582 0.834004747872947 VDAC3/SLC2A3 2 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/167 170/18367 0.789863532272047 0.83811290537755 P4HA1 1 GO:0019787 ubiquitin-like protein transferase activity 3/167 458/18367 0.789991590236256 0.83811290537755 TNFAIP3/UBE2S/PJA2 3 GO:0005201 extracellular matrix structural constituent 1/167 172/18367 0.793702925180902 0.839656269322921 FN1 1 GO:1901981 phosphatidylinositol phosphate binding 1/167 173/18367 0.79559639105036 0.839656269322921 CAPG 1 GO:0004252 serine-type endopeptidase activity 1/167 174/18367 0.797472581151195 0.839656269322921 GZMB 1 GO:0008514 organic anion transmembrane transporter activity 1/167 185/18367 0.817014288544594 0.85807028294382 SLC2A3 1 GO:0048018 receptor ligand activity 3/167 487/18367 0.823246606817591 0.862448826189858 CGA/AREG/METRNL 3 GO:0008236 serine-type peptidase activity 1/167 191/18367 0.826871113800752 0.863605207228947 GZMB 1 GO:0030546 signaling receptor activator activity 3/167 495/18367 0.831597940243516 0.863605207228947 CGA/AREG/METRNL 3 GO:0017171 serine hydrolase activity 1/167 195/18367 0.833147260477728 0.863605207228947 GZMB 1 GO:0016829 lyase activity 1/167 196/18367 0.834680630910274 0.863605207228947 ALDOA 1 GO:0019902 phosphatase binding 1/167 196/18367 0.834680630910274 0.863605207228947 PPP1R15A 1 GO:0005244 voltage-gated ion channel activity 1/167 201/18367 0.842139889916402 0.867030724101123 VDAC3 1 GO:0022832 voltage-gated channel activity 1/167 201/18367 0.842139889916402 0.867030724101123 VDAC3 1 GO:0004518 nuclease activity 1/167 210/18367 0.854733317868031 0.87783421835095 ISG20 1 GO:0000287 magnesium ion binding 1/167 221/18367 0.868776514797317 0.890070056826663 STK4 1 GO:0005125 cytokine activity 1/167 235/18367 0.884714127611889 0.904182164649803 AREG 1 GO:0022804 active transmembrane transporter activity 2/167 406/18367 0.886885503790796 0.904190586791592 TOMM20/NDUFB8 2 GO:0004175 endopeptidase activity 2/167 430/18367 0.905281933105531 0.920700360190054 CFLAR/GZMB 2 GO:0016757 glycosyltransferase activity 1/167 270/18367 0.916632585403269 0.926265690489349 PARP8 1 GO:0005126 cytokine receptor binding 1/167 271/18367 0.917401903977489 0.926265690489349 CFLAR 1 GO:0035091 phosphatidylinositol binding 1/167 271/18367 0.917401903977489 0.926265690489349 CAPG 1 GO:0015267 channel activity 2/167 480/18367 0.935025838220535 0.940017351058407 BAX/VDAC3 2 GO:0022803 passive transmembrane transporter activity 2/167 481/18367 0.935519660383486 0.940017351058407 BAX/VDAC3 2 GO:0022836 gated channel activity 1/167 340/18367 0.956487467068762 0.95878120200178 VDAC3 1 GO:0005216 ion channel activity 1/167 432/18367 0.981558179168827 0.981558179168827 VDAC3 1