ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	31/439	182/18367	6.43720714658648e-18	4.29361716677318e-15	RPS27/RPL34/RPL39/RPS29/RPS28/RPL37A/RPL12/RPL37/RPS14/RPS12/RPL36/RPLP2/RPLP1/RPL31/RPS15A/UBA52/RPS15/RPL21/RPL28/RPS24/RPL30/RPL23/RPL18/RPL35A/RPS11/RPS20/RPL32/RPL38/RPS21/RPL18A/RPS13	31
GO:0045296	cadherin binding	32/439	332/18367	2.27274464061967e-11	7.57960337646661e-09	FLNB/LDHA/HSPA1A/ANXA1/RPL34/EFHD2/EGFR/EMD/PRDX1/EZR/ALDOA/PKM/EIF4H/HSP90AB1/ENO1/RTN4/EPS8L1/ITGB1/PFN1/ITGA6/IDH1/ZC3H15/PKP2/CTTN/NOP56/CD46/BZW2/PPFIBP1/S100P/DDX3X/HSPA5/CTNNA1	32
GO:0043024	ribosomal small subunit binding	6/439	17/18367	1.78331234067364e-06	0.00039648977707644	EIF4H/NPM1/EIF1/NME1/ABCE1/DDX3X	6
GO:0003727	single-stranded RNA binding	11/439	87/18367	7.02061579579035e-06	0.000959761286671833	ANXA1/HNRNPA1/EIF4H/DAZAP1/HNRNPH1/HNRNPC/HNRNPDL/HNRNPF/DDX3X/TIA1/ILF3	11
GO:0051082	unfolded protein binding	13/439	122/18367	7.19461234386681e-06	0.000959761286671833	HSPA1A/HSPA1B/HSP90AB1/DNAJB6/NPM1/PTGES3/CDC37/DNAJA1/PPIA/HSPA9/NAP1L4/HSPA5/TUBB4B	13
GO:0004601	peroxidase activity	8/439	51/18367	2.58405930498419e-05	0.00287261259404076	GPX3/HBB/PRDX1/HBG1/PRDX4/PRDX3/GPX8/HBG2	8
GO:0048027	mRNA 5'-UTR binding	6/439	27/18367	3.48190371020536e-05	0.00331775682100997	RPS14/NCL/GNL3/RPS13/DDX3X/DHX36	6
GO:0004857	enzyme inhibitor activity	9/439	70/18367	4.19451832232034e-05	0.0033686899478973	ANXA1/RPL37/ANXA4/RPS15/DYNLL1/RPL23/RPS20/OAZ1/ABCE1	9
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	8/439	55/18367	4.5454587003112e-05	0.0033686899478973	GPX3/HBB/PRDX1/HBG1/PRDX4/PRDX3/GPX8/HBG2	8
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	4/439	11/18367	9.29776935691755e-05	0.006201612161064	DSP/DSC2/CD47/PKP2	4
GO:0003697	single-stranded DNA binding	11/439	123/18367	0.000179159908130513	0.0108636053384593	ANXA1/HNRNPA1/HNRNPA2B1/NABP1/NME1/SMC4/DHX36/SUB1/TOP1/YBX1/HMGB2	11
GO:0003743	translation initiation factor activity	7/439	51/18367	0.000198297621097618	0.011022042772676	EIF4H/EIF4A1/EIF3A/EIF1/EIF3B/EIF4G1/EIF3L	7
GO:0042826	histone deacetylase binding	11/439	127/18367	0.000237491610352817	0.0121851464696407	HSPA1A/KLF4/HSPA1B/SFPQ/HSP90AB1/HNRNPD/CEBPB/DHX36/KPNA2/CCND1/TOP2A	11
GO:0044183	protein folding chaperone	6/439	40/18367	0.000347251052183076	0.0158000693551964	HSPA1A/HSPA1B/HSP90AB1/DNAJB6/HSPA9/HSPA5	6
GO:0050840	extracellular matrix binding	7/439	56/18367	0.000358530141053991	0.0158000693551964	PLEKHA2/ADGRG1/ITGB1/ITGA6/LGALS3/SMOC1/DAG1	7
GO:0003725	double-stranded RNA binding	8/439	74/18367	0.00037901215844549	0.0158000693551964	EIF4H/HSP90AB1/EIF4A1/TFRC/ACTN1/DHX36/ILF3/TUBB4B	8
GO:0003779	actin binding	23/439	440/18367	0.000405672051823278	0.0159166622685957	FLNB/TMSB10/SYNE1/SCIN/EGFR/EMD/MICAL3/TMSB4X/EZR/ALDOA/CFL1/FMN1/PHACTR2/EPS8L1/ACTN1/ITGB1/PFN1/CTTN/CTNNA1/ADD3/DAG1/COBL/TPM1	23
GO:0001618	virus receptor activity	8/439	76/18367	0.000454922302536302	0.0165834625283091	HSPA1A/CD81/EGFR/HSPA1B/TFRC/ITGB1/CD46/DAG1	8
GO:0043236	laminin binding	5/439	28/18367	0.000475775555030213	0.0165834625283091	PLEKHA2/ITGB1/ITGA6/LGALS3/DAG1	5
GO:0140272	exogenous protein binding	8/439	77/18367	0.000497255248225162	0.0165834625283091	HSPA1A/CD81/EGFR/HSPA1B/TFRC/ITGB1/CD46/DAG1	8
GO:0044389	ubiquitin-like protein ligase binding	18/439	316/18367	0.000635409531617948	0.0201818170280558	UBASH3B/HSPA1A/JUN/UBC/ACTG1/EGFR/HSPA1B/UBA52/HSP90AB1/TPI1/RPL23/RTN4/DNAJA1/CEBPB/UBE2J1/CCNB1/HSPA9/HSPA5	18
GO:0008135	translation factor activity, RNA binding	8/439	84/18367	0.000891269528438129	0.0265817557156161	EIF4H/EIF4A1/EIF3A/EIF1/EIF3B/EIF4G1/EIF5A/EIF3L	8
GO:0043021	ribonucleoprotein complex binding	11/439	149/18367	0.000923265314085429	0.0265817557156161	YBX3/RPLP1/EIF4H/NPM1/EIF1/NME1/ABCE1/EIF5A/C1QBP/DDX3X/HSPA5	11
GO:0140678	molecular function inhibitor activity	10/439	128/18367	0.00101371229094429	0.0265817557156161	ANXA1/CAV1/RPL37/ANXA4/RPS15/DYNLL1/RPL23/RPS20/OAZ1/ABCE1	10
GO:0016209	antioxidant activity	8/439	86/18367	0.00104085186099646	0.0265817557156161	GPX3/HBB/PRDX1/HBG1/PRDX4/PRDX3/GPX8/HBG2	8
GO:0097110	scaffold protein binding	7/439	67/18367	0.00107374182554315	0.0265817557156161	DSP/KRT8/ITPR2/DYNLL1/CDC37/IL6ST/ATP2B4	7
GO:0031072	heat shock protein binding	10/439	129/18367	0.00107602309493499	0.0265817557156161	HSPA1A/HSPA1B/HSP90AB1/DNAJB6/PTGES3/CDC37/DNAJA1/CHORDC1/HSPA9/HSPA5	10
GO:0019843	rRNA binding	7/439	68/18367	0.00117279720118556	0.0279377047568132	RPL12/RPL37/RPS14/NPM1/RPL23/RPS11/RPS13	7
GO:0005539	glycosaminoglycan binding	14/439	230/18367	0.00132910891744347	0.0305695051011999	GREM2/FBN1/FSTL1/LAMC2/HDGF/ADGRG1/HSD17B12/BMP7/NRP2/PPIA/C1QBP/GNS/EXTL2/SMOC1	14
GO:0030957	Tat protein binding	3/439	10/18367	0.00143592181438451	0.0308954790385313	ACTB/NPM1/DNAJA1	3
GO:0031720	haptoglobin binding	3/439	10/18367	0.00143592181438451	0.0308954790385313	HBB/HBG1/HBG2	3
GO:0055106	ubiquitin-protein transferase regulator activity	4/439	22/18367	0.00167317150678248	0.0348751685944974	RPL37/RPS15/RPL23/RPS20	4
GO:0097371	MDM2/MDM4 family protein binding	3/439	11/18367	0.00193952585969026	0.0380489337768647	RPL37/RPS15/RPS20	3
GO:0099186	structural constituent of postsynapse	3/439	11/18367	0.00193952585969026	0.0380489337768647	ACTG1/ACTB/ACTN1	3
GO:0031625	ubiquitin protein ligase binding	16/439	297/18367	0.00220658616986213	0.0420512278656583	UBASH3B/HSPA1A/JUN/UBC/ACTG1/EGFR/HSPA1B/UBA52/HSP90AB1/TPI1/RPL23/RTN4/DNAJA1/UBE2J1/HSPA9/HSPA5	16
GO:0017166	vinculin binding	3/439	12/18367	0.0025404218998023	0.0470683724213371	ACTN1/CTNNA1/DAG1	3
GO:0035925	mRNA 3'-UTR AU-rich region binding	4/439	25/18367	0.00273443167217716	0.0488861856465746	HNRNPD/DHX36/TIA1/ILF3	4
GO:0098631	cell adhesion mediator activity	6/439	59/18367	0.00278512002184383	0.0488861856465746	ANXA1/DSP/DSC2/ITGB1/CD47/PKP2	6
GO:0031994	insulin-like growth factor I binding	3/439	13/18367	0.00324436890995328	0.0547895622967108	IGFBP3/ITGA6/LRP2	3
GO:0005200	structural constituent of cytoskeleton	8/439	103/18367	0.00328573087236646	0.0547895622967108	KRT19/DSP/ACTG1/ACTB/TUBA1C/ADD3/TUBB4B/TPM1	8
GO:0061134	peptidase regulator activity	13/439	230/18367	0.00370154875568988	0.0602178785376866	SERPINB9/CAV1/GAPDH/TIMP3/SPINT1/PTTG1/TFPI/SPINT2/SERPINB1/PRDX3/SERPINF1/CTSC/SERPINE1	13
GO:0005344	oxygen carrier activity	3/439	14/18367	0.00405654358013915	0.0606570980752926	HBB/HBG1/HBG2	3
GO:0140666	annealing activity	3/439	14/18367	0.00405654358013915	0.0606570980752926	ANXA1/EIF4H/DDX3X	3
GO:0004866	endopeptidase inhibitor activity	11/439	180/18367	0.00410042996832838	0.0606570980752926	SERPINB9/GAPDH/TIMP3/SPINT1/PTTG1/TFPI/SPINT2/SERPINB1/PRDX3/SERPINF1/SERPINE1	11
GO:0001968	fibronectin binding	4/439	28/18367	0.00418324814312363	0.0606570980752926	IGFBP3/PLEKHA2/HSD17B12/ITGB1	4
GO:0003785	actin monomer binding	4/439	28/18367	0.00418324814312363	0.0606570980752926	TMSB10/TMSB4X/PFN1/COBL	4
GO:0090079	translation regulator activity, nucleic acid binding	8/439	108/18367	0.00439019155221711	0.0623033567091236	EIF4H/EIF4A1/EIF3A/EIF1/EIF3B/EIF4G1/EIF5A/EIF3L	8
GO:0005520	insulin-like growth factor binding	4/439	29/18367	0.00476237319218607	0.0630469704823885	IGFBP3/ITGA6/LRP2/HTRA1	4
GO:0051787	misfolded protein binding	4/439	29/18367	0.00476237319218607	0.0630469704823885	HSPA1A/HSPA1B/HSPA9/HSPA5	4
GO:0070717	poly-purine tract binding	4/439	29/18367	0.00476237319218607	0.0630469704823885	DAZAP1/HNRNPDL/DDX3X/TIA1	4
GO:1901681	sulfur compound binding	14/439	265/18367	0.0048206829004525	0.0630469704823885	GREM2/FBN1/FSTL1/LAMC2/HDGF/ADGRG1/HSD17B12/BMP7/NRP2/PPIA/TKT/METTL17/SMOC1/GSTM3	14
GO:0050998	nitric-oxide synthase binding	3/439	15/18367	0.00498157068706121	0.063898224005189	CAV1/ACTB/ATP2B4	3
GO:0030414	peptidase inhibitor activity	11/439	187/18367	0.00544899404150998	0.0685750759563615	SERPINB9/GAPDH/TIMP3/SPINT1/PTTG1/TFPI/SPINT2/SERPINB1/PRDX3/SERPINF1/SERPINE1	11
GO:0098632	cell-cell adhesion mediator activity	5/439	49/18367	0.00612739088763289	0.0756846244824285	ANXA1/DSP/DSC2/CD47/PKP2	5
GO:0045182	translation regulator activity	9/439	140/18367	0.00655176164373275	0.07835499010965	RPS14/EIF4H/EIF4A1/EIF3A/EIF1/EIF3B/EIF4G1/EIF5A/EIF3L	9
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5/439	50/18367	0.00667755071987012	0.07835499010965	CCNL1/CCNB1/CCNL2/CCND1/CCNE1	5
GO:0008201	heparin binding	10/439	166/18367	0.0066960036525488	0.07835499010965	GREM2/FBN1/FSTL1/LAMC2/HDGF/ADGRG1/HSD17B12/BMP7/NRP2/SMOC1	10
GO:0140297	DNA-binding transcription factor binding	18/439	394/18367	0.00687434735741403	0.0790549946102613	JUN/ISL1/KLF4/JUND/ANXA4/ACTB/NPM1/PTMA/DCAF13/RBFOX2/TACC1/FOS/DNAJA1/CEBPB/FUS/TRIM24/CENPF/ZMYND8	18
GO:0061135	endopeptidase regulator activity	11/439	194/18367	0.0071256709589271	0.0805563140610911	SERPINB9/GAPDH/TIMP3/SPINT1/PTTG1/TFPI/SPINT2/SERPINB1/PRDX3/SERPINF1/SERPINE1	11
GO:0031369	translation initiation factor binding	4/439	33/18367	0.00761299667186595	0.0846311463355764	RPS24/EIF3B/EIF4G1/DDX3X	4
GO:0008301	DNA binding, bending	3/439	18/18367	0.00847233880456848	0.0911459674620512	HMGB3/TOP2A/HMGB2	3
GO:0098918	structural constituent of synapse	3/439	18/18367	0.00847233880456848	0.0911459674620512	ACTG1/ACTB/ACTN1	3
GO:0004867	serine-type endopeptidase inhibitor activity	7/439	98/18367	0.00911224147399278	0.0964740486214791	SERPINB9/SPINT1/TFPI/SPINT2/SERPINB1/SERPINF1/SERPINE1	7
GO:0005080	protein kinase C binding	5/439	55/18367	0.00995325561413407	0.103159150901624	DSP/SRSF2/PKP2/C1QBP/TOP2A	5
GO:0038024	cargo receptor activity	6/439	77/18367	0.0102499265410102	0.103159150901624	OLR1/ACKR2/TFRC/COLEC12/DAB2/LRP2	6
GO:0042162	telomeric DNA binding	4/439	36/18367	0.0103623135088588	0.103159150901624	HNRNPA1/NCL/HNRNPA2B1/HNRNPD	4
GO:0097718	disordered domain specific binding	4/439	36/18367	0.0103623135088588	0.103159150901624	HSPA1A/GAPDH/EZR/HSP90AB1	4
GO:0009055	electron transfer activity	8/439	126/18367	0.0108400510663689	0.106328147959824	UQCR10/CYB5A/ETFB/CYCS/NDUFB1/NDUFA3/COX5B/UQCR11	8
GO:0031690	adrenergic receptor binding	3/439	20/18367	0.0114262952994801	0.110454187894975	ADRB1/C1QBP/ARRDC3	3
GO:0008238	exopeptidase activity	7/439	103/18367	0.0118017262508446	0.112453591561619	DPP7/CPVL/CNDP2/TFRC/CPM/MME/CTSC	7
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	14/439	299/18367	0.0131917630686189	0.123928253053082	JUN/ISL1/KLF4/JUND/ANXA4/ACTB/NPM1/DCAF13/TACC1/FOS/DNAJA1/CEBPB/FUS/TRIM24	14
GO:0051087	chaperone binding	7/439	107/18367	0.0143334726506834	0.132783698027858	DNAJB6/PTGES3/CDC37/DNAJA1/CTSC/HSPA5/LRP2	7
GO:0051015	actin filament binding	11/439	217/18367	0.0155802211152749	0.14235626690258	FLNB/SYNE1/SCIN/EGFR/EZR/CFL1/ACTN1/CTTN/CTNNA1/ADD3/TPM1	11
GO:0030331	estrogen receptor binding	4/439	41/18367	0.0162332802243022	0.146318890670399	ISL1/DCAF13/TACC1/FUS	4
GO:0047485	protein N-terminus binding	7/439	110/18367	0.0164710965282446	0.146482951791189	HSPA1A/HSPA1B/NPM1/SRRM2/RPS21/EIF5A/ZMYND8	7
GO:0008143	poly(A) binding	3/439	23/18367	0.016839298859425	0.147787004463638	HNRNPDL/DDX3X/TIA1	3
GO:0019955	cytokine binding	8/439	139/18367	0.0186550153475839	0.159524297908186	GREM2/CSF3R/ACKR2/ITGB1/LIFR/NRP2/IL6ST/PRLR	8
GO:0020037	heme binding	8/439	139/18367	0.0186550153475839	0.159524297908186	CYP2J2/HBB/CYP11A1/HMOX1/HBG1/CYB5A/CYCS/HBG2	8
GO:0019838	growth factor binding	8/439	141/18367	0.0201424251269518	0.170063260249074	IGFBP3/EGFR/LIFR/ITGA6/NRP2/IL6ST/LRP2/HTRA1	8
GO:0008266	poly(U) RNA binding	3/439	25/18367	0.0211163787234737	0.175209645951253	DAZAP1/HNRNPH1/HNRNPC	3
GO:0005522	profilin binding	2/439	10/18367	0.022590748953235	0.175209645951253	ACTG1/CTTN	2
GO:0008190	eukaryotic initiation factor 4E binding	2/439	10/18367	0.022590748953235	0.175209645951253	EIF4G1/DDX3X	2
GO:0008239	dipeptidyl-peptidase activity	2/439	10/18367	0.022590748953235	0.175209645951253	DPP7/CTSC	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/439	10/18367	0.022590748953235	0.175209645951253	DUSP5/DUSP6	2
GO:0016783	sulfurtransferase activity	2/439	10/18367	0.022590748953235	0.175209645951253	TSTD1/MOCS2	2
GO:0098505	G-rich strand telomeric DNA binding	2/439	10/18367	0.022590748953235	0.175209645951253	HNRNPA1/HNRNPA2B1	2
GO:0019207	kinase regulator activity	11/439	233/18367	0.0248633481733003	0.190619002661969	KLF4/RPLP1/CCNL1/HSP90AB1/NPM1/CDC37/CCNB1/DDX3X/CCNL2/CCND1/CCNE1	11
GO:0019887	protein kinase regulator activity	10/439	204/18367	0.0252102265680052	0.191082058191584	RPLP1/CCNL1/HSP90AB1/NPM1/CDC37/CCNB1/DDX3X/CCNL2/CCND1/CCNE1	10
GO:0023026	MHC class II protein complex binding	3/439	27/18367	0.0259324582405104	0.192373122761955	CD81/PKM/HSP90AB1	3
GO:0046906	tetrapyrrole binding	8/439	149/18367	0.0269380849212428	0.192373122761955	CYP2J2/HBB/CYP11A1/HMOX1/HBG1/CYB5A/CYCS/HBG2	8
GO:0000774	adenyl-nucleotide exchange factor activity	2/439	11/18367	0.0271799096406894	0.192373122761955	HSPH1/PFN1	2
GO:0005536	glucose binding	2/439	11/18367	0.0271799096406894	0.192373122761955	SLC2A3/PYGL	2
GO:0097493	structural molecule activity conferring elasticity	2/439	11/18367	0.0271799096406894	0.192373122761955	FBN1/FBN2	2
GO:1990226	histone methyltransferase binding	2/439	11/18367	0.0271799096406894	0.192373122761955	HSP90AB1/NOP56	2
GO:0048029	monosaccharide binding	5/439	71/18367	0.0273994702584494	0.192373122761955	SLC2A3/P3H2/ALDOA/PYGL/COLEC12	5
GO:0008187	poly-pyrimidine tract binding	3/439	28/18367	0.0285423634521969	0.196613222160168	DAZAP1/HNRNPH1/HNRNPC	3
GO:0003678	DNA helicase activity	5/439	72/18367	0.0288876998076409	0.196613222160168	ANXA1/ASCC3/DDX3X/DHX36/CHD2	5
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5/439	72/18367	0.0288876998076409	0.196613222160168	UQCR10/CYB5A/NDUFB1/NDUFA3/COX5B	5
GO:0140104	molecular carrier activity	5/439	73/18367	0.0304260912794541	0.20499194831713	HBB/NUTF2/HBG1/KPNA2/HBG2	5
GO:0016887	ATP hydrolysis activity	12/439	272/18367	0.0310751121913288	0.207270998316163	HSPA1A/HSPA1B/EIF4A1/ASCC3/DDX39B/ATP2B4/DDX3X/DHX36/HSPA9/ATP10D/HSPA5/CHD2	12
GO:0017154	semaphorin receptor activity	2/439	12/18367	0.0321078071888668	0.207921431019167	NRP2/MET	2
GO:0043047	single-stranded telomeric DNA binding	2/439	12/18367	0.0321078071888668	0.207921431019167	HNRNPA1/HNRNPA2B1	2
GO:0043422	protein kinase B binding	2/439	12/18367	0.0321078071888668	0.207921431019167	SRSF5/SRSF1	2
GO:0015631	tubulin binding	15/439	375/18367	0.0367728825444388	0.228589497922257	STMN3/EMD/GAPDH/CCSAP/CAPN6/EZR/ALDOA/HSPH1/FMN1/NME1/DDX3X/CENPF/STMN1/DAG1/REEP3	15
GO:0004859	phospholipase inhibitor activity	2/439	13/18367	0.0373557050577602	0.228589497922257	ANXA1/ANXA4	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/439	13/18367	0.0373557050577602	0.228589497922257	DUSP5/DUSP6	2
GO:0031386	protein tag	2/439	13/18367	0.0373557050577602	0.228589497922257	UBC/UBA52	2
GO:0060590	ATPase regulator activity	2/439	13/18367	0.0373557050577602	0.228589497922257	HSPH1/PFN1	2
GO:0072542	protein phosphatase activator activity	2/439	13/18367	0.0373557050577602	0.228589497922257	IGFBP3/PPP1R15A	2
GO:0000287	magnesium ion binding	10/439	221/18367	0.0402701496182537	0.24418354359432	PKM/ENO1/NME1/PDCD6/IDH1/TKT/S100P/DHX36/ATP10D/TOP2A	10
GO:0035259	glucocorticoid receptor binding	2/439	14/18367	0.0429055653040304	0.257819928448543	TACC1/CEBPB	2
GO:0051287	NAD binding	4/439	56/18367	0.0446615095692614	0.265975240024083	LDHA/GAPDH/IDH1/HPGD	4
GO:0035198	miRNA binding	3/439	34/18367	0.0469808736247866	0.273144786908019	HNRNPA1/HNRNPA2B1/YBX1	3
GO:0003712	transcription coregulator activity	18/439	489/18367	0.047300406491838	0.273144786908019	HSPA1A/PAGE4/NPM1/RBFOX2/HDGF/TACC1/EWSR1/ACTN1/SRSF2/ARID3A/C1QBP/FUS/TRIM24/SUB1/CCND1/ZMYND8/BASP1/HMGB2	18
GO:0051020	GTPase binding	12/439	291/18367	0.0478261788041306	0.273144786908019	YBX3/CAV1/MICAL3/ENO1/ERRFI1/NUTF2/PFN1/GOLGA4/EXPH5/C9orf72/YBX1/CDKL5	12
GO:0005041	low-density lipoprotein particle receptor activity	2/439	15/18367	0.0487400260143333	0.273144786908019	OLR1/LRP2	2
GO:0019215	intermediate filament binding	2/439	15/18367	0.0487400260143333	0.273144786908019	NME1/PKP2	2
GO:0098847	sequence-specific single stranded DNA binding	2/439	15/18367	0.0487400260143333	0.273144786908019	HNRNPA1/HNRNPA2B1	2
GO:1990825	sequence-specific mRNA binding	2/439	15/18367	0.0487400260143333	0.273144786908019	SRSF3/SRSF4	2
GO:0140097	catalytic activity, acting on DNA	10/439	229/18367	0.0491414908979944	0.273144786908019	ANXA1/DNMT1/PTGES3/NME1/ASCC3/DDX3X/DHX36/TOP1/CHD2/TOP2A	10
GO:0008094	ATP-dependent activity, acting on DNA	6/439	111/18367	0.0503086349834446	0.277321153173203	ANXA1/ASCC3/DDX3X/DHX36/CHD2/TOP2A	6
GO:0003730	mRNA 3'-UTR binding	9/439	201/18367	0.0528404539594515	0.288890022876673	YBX3/HNRNPA2B1/HNRNPD/DAZAP1/HNRNPC/FUS/DHX36/TIA1/ILF3	9
GO:0000217	DNA secondary structure binding	3/439	36/18367	0.0541549373115724	0.290316405312815	HMGB3/HNRNPD/HMGB2	3
GO:0023023	MHC protein complex binding	3/439	36/18367	0.0541549373115724	0.290316405312815	CD81/PKM/HSP90AB1	3
GO:0005521	lamin binding	2/439	16/18367	0.0548423794144149	0.290316405312815	SYNE1/BNIP3L	2
GO:0017070	U6 snRNA binding	2/439	16/18367	0.0548423794144149	0.290316405312815	EIF5A/DDX39B	2
GO:0005178	integrin binding	7/439	144/18367	0.0578772097616949	0.301594522742582	FBN1/CD81/EGFR/ITGB8/ACTN1/ITGB1/PPIA	7
GO:0016922	nuclear receptor binding	7/439	144/18367	0.0578772097616949	0.301594522742582	ISL1/JUND/DCAF13/TACC1/CEBPB/FUS/TRIM24	7
GO:0048306	calcium-dependent protein binding	5/439	88/18367	0.0597211830822707	0.304612681144242	ANXA1/ANXA4/PDCD6/ATP2B4/S100P	5
GO:1990841	promoter-specific chromatin binding	4/439	62/18367	0.0608039583125215	0.304612681144242	ISL1/KLF4/EGR1/DNMT1	4
GO:0000400	four-way junction DNA binding	2/439	17/18367	0.0611965506346753	0.304612681144242	HMGB3/HMGB2	2
GO:0008484	sulfuric ester hydrolase activity	2/439	17/18367	0.0611965506346753	0.304612681144242	STS/GNS	2
GO:0046965	retinoid X receptor binding	2/439	17/18367	0.0611965506346753	0.304612681144242	TACC1/FUS	2
GO:0070064	proline-rich region binding	2/439	17/18367	0.0611965506346753	0.304612681144242	PFN1/CCND1	2
GO:0019888	protein phosphatase regulator activity	5/439	89/18367	0.0620955257741987	0.3067978940103	IGFBP3/PPP1R15A/PPP1R14B/PHACTR2/LGALS3	5
GO:0019825	oxygen binding	3/439	39/18367	0.0658313072700779	0.322863837861338	HBB/HBG1/HBG2	3
GO:0030228	lipoprotein particle receptor activity	2/439	18/18367	0.0677870771134386	0.325280434781752	OLR1/LRP2	2
GO:0033549	MAP kinase phosphatase activity	2/439	18/18367	0.0677870771134386	0.325280434781752	DUSP5/DUSP6	2
GO:0055102	lipase inhibitor activity	2/439	18/18367	0.0677870771134386	0.325280434781752	ANXA1/ANXA4	2
GO:0017080	sodium channel regulator activity	3/439	40/18367	0.0699589270028051	0.333304316506221	PKP2/ATP2B4/FXYD3	3
GO:0004129	cytochrome-c oxidase activity	2/439	19/18367	0.0745990886196819	0.350394272433106	CYB5A/COX5B	2
GO:0035613	RNA stem-loop binding	2/439	19/18367	0.0745990886196819	0.350394272433106	DAZAP1/DDX3X	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	16/439	450/18367	0.0751220104316855	0.350394272433106	JUN/TFDP2/ISL1/FOSB/KLF4/JUND/JUNB/KLF6/GRHL1/EGR1/ZNF175/ATF3/FOS/CEBPB/ETV5/DMTF1	16
GO:0001046	core promoter sequence-specific DNA binding	3/439	42/18367	0.078553350775319	0.357233049635824	NPM1/FOS/CEBPB	3
GO:0008307	structural constituent of muscle	3/439	42/18367	0.078553350775319	0.357233049635824	KRT19/DAG1/TPM1	3
GO:0003714	transcription corepressor activity	8/439	187/18367	0.0805773048099055	0.357233049635824	HSPA1A/RBFOX2/HDGF/SRSF2/C1QBP/CCND1/ZMYND8/BASP1	8
GO:0004386	helicase activity	7/439	156/18367	0.0810202982483576	0.357233049635824	ANXA1/EIF4A1/ASCC3/DDX39B/DDX3X/DHX36/CHD2	7
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/439	20/18367	0.081618287877482	0.357233049635824	FOS/CEBPB	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/439	20/18367	0.081618287877482	0.357233049635824	CYB5A/COX5B	2
GO:0019211	phosphatase activator activity	2/439	20/18367	0.081618287877482	0.357233049635824	IGFBP3/PPP1R15A	2
GO:0061608	nuclear import signal receptor activity	2/439	20/18367	0.081618287877482	0.357233049635824	NUTF2/KPNA2	2
GO:0001216	DNA-binding transcription activator activity	16/439	456/18367	0.0821438963893072	0.357233049635824	JUN/TFDP2/ISL1/FOSB/KLF4/JUND/JUNB/KLF6/GRHL1/EGR1/ZNF175/ATF3/FOS/CEBPB/ETV5/DMTF1	16
GO:0004896	cytokine receptor activity	5/439	97/18367	0.0829731131336278	0.357233049635824	CSF3R/ACKR2/LIFR/IL6ST/PRLR	5
GO:0005518	collagen binding	4/439	69/18367	0.0830100844578387	0.357233049635824	ADGRG1/HSD17B12/ITGB1/CRTAP	4
GO:0004180	carboxypeptidase activity	3/439	43/18367	0.0830151764521029	0.357233049635824	CPVL/CNDP2/CPM	3
GO:0016853	isomerase activity	7/439	158/18367	0.0853307136960254	0.364843500225955	CYP2J2/ISYNA1/TPI1/PTGES3/PPIA/TOP1/TOP2A	7
GO:0051879	Hsp90 protein binding	3/439	44/18367	0.0875833090376116	0.372089599541955	PTGES3/CDC37/CHORDC1	3
GO:0070577	lysine-acetylated histone binding	2/439	21/18367	0.0888309317749327	0.372642965370315	TRIM24/ZMYND8	2
GO:0140033	acetylation-dependent protein binding	2/439	21/18367	0.0888309317749327	0.372642965370315	TRIM24/ZMYND8	2
GO:0048156	tau protein binding	3/439	45/18367	0.0922550958012001	0.382944164793704	HSP90AB1/ACTB/LGMN	3
GO:0031267	small GTPase binding	10/439	259/18367	0.0935935381504715	0.382944164793704	YBX3/CAV1/MICAL3/ERRFI1/NUTF2/PFN1/GOLGA4/EXPH5/C9orf72/CDKL5	10
GO:0004602	glutathione peroxidase activity	2/439	22/18367	0.0962238131407572	0.382944164793704	GPX3/GPX8	2
GO:0005355	glucose transmembrane transporter activity	2/439	22/18367	0.0962238131407572	0.382944164793704	SLC2A3/SLC2A12	2
GO:0015149	hexose transmembrane transporter activity	2/439	22/18367	0.0962238131407572	0.382944164793704	SLC2A3/SLC2A12	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/439	22/18367	0.0962238131407572	0.382944164793704	SERPINB9/PRDX3	2
GO:0070034	telomerase RNA binding	2/439	22/18367	0.0962238131407572	0.382944164793704	HNRNPC/DHX36	2
GO:0070182	DNA polymerase binding	2/439	22/18367	0.0962238131407572	0.382944164793704	HSP90AB1/PTGES3	2
GO:0004864	protein phosphatase inhibitor activity	3/439	46/18367	0.0970278318592743	0.382944164793704	PPP1R14B/PHACTR2/LGALS3	3
GO:0061980	regulatory RNA binding	3/439	46/18367	0.0970278318592743	0.382944164793704	HNRNPA1/HNRNPA2B1/YBX1	3
GO:0044325	transmembrane transporter binding	6/439	133/18367	0.0997767828068743	0.39147714195403	CAV1/HSP90AB1/ITPR2/ACTN1/PKP2/HERPUD1	6
GO:0070412	R-SMAD binding	2/439	23/18367	0.103784243072313	0.404819240521828	JUN/FOS	2
GO:0002020	protease binding	6/439	135/18367	0.105219542560365	0.408031598184673	SERPINB9/UBC/TIMP3/ITGB1/ADAMTSL4/SERPINE1	6
GO:0015145	monosaccharide transmembrane transporter activity	2/439	24/18367	0.11150003379913	0.424119876554454	SLC2A3/SLC2A12	2
GO:0043274	phospholipase binding	2/439	24/18367	0.11150003379913	0.424119876554454	SRSF3/PRKCZ	2
GO:0043495	protein-membrane adaptor activity	2/439	24/18367	0.11150003379913	0.424119876554454	SYNE1/PDCD6	2
GO:0019212	phosphatase inhibitor activity	3/439	49/18367	0.111924044531034	0.424119876554454	PPP1R14B/PHACTR2/LGALS3	3
GO:0003724	RNA helicase activity	4/439	77/18367	0.112547553448483	0.424119876554454	EIF4A1/DDX39B/DDX3X/DHX36	4
GO:0019208	phosphatase regulator activity	5/439	107/18367	0.113614739711218	0.42573613138979	IGFBP3/PPP1R15A/PPP1R14B/PHACTR2/LGALS3	5
GO:0030246	carbohydrate binding	10/439	271/18367	0.11647018265444	0.431806120275006	GALNT11/SLC2A3/P3H2/ALDOA/AGL/OLR1/SIGLEC6/PYGL/COLEC12/LGALS3	10
GO:0001221	transcription coregulator binding	4/439	78/18367	0.116529387780361	0.431806120275006	KLF4/UBE2I/HDGF/RPL23	4
GO:0035035	histone acetyltransferase binding	2/439	25/18367	0.119359482066579	0.439849583085128	EGR1/CEBPB	2
GO:0008186	ATP-dependent activity, acting on RNA	4/439	79/18367	0.120572000113884	0.441876505911873	EIF4A1/DDX39B/DDX3X/DHX36	4
GO:0042974	retinoic acid receptor binding	2/439	26/18367	0.127351353024664	0.464171324958746	TACC1/FUS	2
GO:0017069	snRNA binding	3/439	53/18367	0.133028373209501	0.48222785288444	EIF5A/DDX39B/SNRNP70	3
GO:0001671	ATPase activator activity	2/439	27/18367	0.135464864607396	0.483182164134401	DNAJB6/DNAJA1	2
GO:0022884	macromolecule transmembrane transporter activity	2/439	27/18367	0.135464864607396	0.483182164134401	HNRNPA3/MCL1	2
GO:0051119	sugar transmembrane transporter activity	2/439	27/18367	0.135464864607396	0.483182164134401	SLC2A3/SLC2A12	2
GO:0030165	PDZ domain binding	4/439	84/18367	0.141655496061403	0.50257561634551	PLEKHA2/CADM1/ADRB1/ATP2B4	4
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/439	28/18367	0.143689672388565	0.507095298852767	PDCD6/HERPUD1	2
GO:0004869	cysteine-type endopeptidase inhibitor activity	3/439	56/18367	0.149687584043392	0.51731926131836	SERPINB9/PTTG1/PRDX3	3
GO:0042562	hormone binding	4/439	86/18367	0.150472206815061	0.51731926131836	EGFR/SLC40A1/LRP2/PRLR	4
GO:0019903	protein phosphatase binding	6/439	150/18367	0.150684838007348	0.51731926131836	PPP1R15A/EGFR/KCNN4/ATP2B4/MET/LGALS3	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2/439	29/18367	0.152015854900148	0.51731926131836	CDK12/CDKL5	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/439	29/18367	0.152015854900148	0.51731926131836	PLEKHA2/TTPA	2
GO:0051059	NF-kappaB binding	2/439	29/18367	0.152015854900148	0.51731926131836	ANXA4/NPM1	2
GO:0097472	cyclin-dependent protein kinase activity	2/439	29/18367	0.152015854900148	0.51731926131836	CDK12/CDKL5	2
GO:0046966	thyroid hormone receptor binding	2/439	30/18367	0.160433899399967	0.543194979186692	TACC1/FUS	2
GO:0051117	ATPase binding	4/439	89/18367	0.164076096931297	0.552720993197855	CAV1/EGFR/EZR/NOP58	4
GO:0036002	pre-mRNA binding	3/439	59/18367	0.16697193278238	0.555071117962661	HNRNPA1/SRSF6/SRSF2	3
GO:0008022	protein C-terminus binding	7/439	189/18367	0.167847599104063	0.555071117962661	EZR/NCL/MKI67/PRDX3/CENPF/DAB2/TOP2A	7
GO:0043015	gamma-tubulin binding	2/439	31/18367	0.168934688075593	0.555071117962661	NME1/DDX3X	2
GO:0140142	nucleocytoplasmic carrier activity	2/439	31/18367	0.168934688075593	0.555071117962661	NUTF2/KPNA2	2
GO:0140318	protein transporter activity	2/439	31/18367	0.168934688075593	0.555071117962661	MCL1/LRP2	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	5/439	124/18367	0.175990037143581	0.57541840575867	LDHA/RDH13/HSD17B12/IDH1/HPGD	5
GO:0030515	snoRNA binding	2/439	32/18367	0.177509484671825	0.577555250127352	NOP58/NOP56	2
GO:0005154	epidermal growth factor receptor binding	2/439	33/18367	0.186149921529482	0.599816413817221	ARF4/VAV3	2
GO:0019956	chemokine binding	2/439	33/18367	0.186149921529482	0.599816413817221	ACKR2/ITGB1	2
GO:0019902	phosphatase binding	7/439	196/18367	0.190160317171425	0.60979294016029	PPP1R15A/EGFR/KCNN4/ATP2B4/MET/CTSC/LGALS3	7
GO:0008376	acetylgalactosaminyltransferase activity	2/439	34/18367	0.194847987023526	0.616558483675431	GALNT11/EXTL2	2
GO:0017124	SH3 domain binding	5/439	130/18367	0.20059378334301	0.616558483675431	ERRFI1/PTTG1/FMN1/SH3BGRL2/LRP2	5
GO:0043022	ribosome binding	3/439	66/18367	0.209299197025032	0.616558483675431	EIF5A/C1QBP/HSPA5	3
GO:0001094	TFIID-class transcription factor complex binding	1/439	10/18367	0.214926873929491	0.616558483675431	NOP58	1
GO:0004955	prostaglandin receptor activity	1/439	10/18367	0.214926873929491	0.616558483675431	HPGD	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/439	10/18367	0.214926873929491	0.616558483675431	UBA5	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/439	10/18367	0.214926873929491	0.616558483675431	PIK3C2A	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/439	10/18367	0.214926873929491	0.616558483675431	SLC27A2	1
GO:0045294	alpha-catenin binding	1/439	10/18367	0.214926873929491	0.616558483675431	PKP2	1
GO:0050786	RAGE receptor binding	1/439	10/18367	0.214926873929491	0.616558483675431	HMGB2	1
GO:0051880	G-quadruplex DNA binding	1/439	10/18367	0.214926873929491	0.616558483675431	DHX36	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/439	10/18367	0.214926873929491	0.616558483675431	PIK3C2A	1
GO:0070008	serine-type exopeptidase activity	1/439	10/18367	0.214926873929491	0.616558483675431	CPVL	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/439	10/18367	0.214926873929491	0.616558483675431	ADRB1	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/439	37/18367	0.221212926552668	0.616558483675431	GAPDH/HSD17B12	2
GO:0042056	chemoattractant activity	2/439	37/18367	0.221212926552668	0.616558483675431	LGALS3/HMGB2	2
GO:0046915	transition metal ion transmembrane transporter activity	2/439	37/18367	0.221212926552668	0.616558483675431	SLC40A1/SLC25A37	2
GO:0016782	transferase activity, transferring sulphur-containing groups	3/439	68/18367	0.221806101988271	0.616558483675431	TSTD1/HS6ST2/MOCS2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	5/439	136/18367	0.226279545165664	0.616558483675431	LDHA/RDH13/HSD17B12/IDH1/HPGD	5
GO:0004497	monooxygenase activity	4/439	102/18367	0.227445143783642	0.616558483675431	CYP2J2/CYP11A1/MICAL3/HMOX1	4
GO:0004725	protein tyrosine phosphatase activity	4/439	102/18367	0.227445143783642	0.616558483675431	UBASH3B/PTPRG/DUSP5/DUSP6	4
GO:0008395	steroid hydroxylase activity	2/439	38/18367	0.230068092758118	0.616558483675431	CYP2J2/CYP11A1	2
GO:0002162	dystroglycan binding	1/439	11/18367	0.233701570358371	0.616558483675431	DAG1	1
GO:0004016	adenylate cyclase activity	1/439	11/18367	0.233701570358371	0.616558483675431	ADCY7	1
GO:0004143	diacylglycerol kinase activity	1/439	11/18367	0.233701570358371	0.616558483675431	DGKD	1
GO:0004954	prostanoid receptor activity	1/439	11/18367	0.233701570358371	0.616558483675431	HPGD	1
GO:0005078	MAP-kinase scaffold activity	1/439	11/18367	0.233701570358371	0.616558483675431	SPAG9	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/439	11/18367	0.233701570358371	0.616558483675431	PCYOX1	1
GO:0016832	aldehyde-lyase activity	1/439	11/18367	0.233701570358371	0.616558483675431	ALDOA	1
GO:0032052	bile acid binding	1/439	11/18367	0.233701570358371	0.616558483675431	PYGL	1
GO:0042608	T cell receptor binding	1/439	11/18367	0.233701570358371	0.616558483675431	EPS8L1	1
GO:0043295	glutathione binding	1/439	11/18367	0.233701570358371	0.616558483675431	GSTM3	1
GO:0043560	insulin receptor substrate binding	1/439	11/18367	0.233701570358371	0.616558483675431	PRKCZ	1
GO:0047676	arachidonate-CoA ligase activity	1/439	11/18367	0.233701570358371	0.616558483675431	SLC27A2	1
GO:0051400	BH domain binding	1/439	11/18367	0.233701570358371	0.616558483675431	MCL1	1
GO:0070513	death domain binding	1/439	11/18367	0.233701570358371	0.616558483675431	MCL1	1
GO:1901474	azole transmembrane transporter activity	1/439	11/18367	0.233701570358371	0.616558483675431	SLC28A2	1
GO:1901612	cardiolipin binding	1/439	11/18367	0.233701570358371	0.616558483675431	MME	1
GO:1990459	transferrin receptor binding	1/439	11/18367	0.233701570358371	0.616558483675431	CD81	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	2/439	39/18367	0.238945756838553	0.616558483675431	UBE2I/UBE2J1	2
GO:0099106	ion channel regulator activity	5/439	139/18367	0.23947269906579	0.616558483675431	CAV1/PKP2/ATP2B4/FXYD3/PRKCZ	5
GO:0031491	nucleosome binding	3/439	71/18367	0.240830816958839	0.616558483675431	ACTB/HNRNPC/NAP1L4	3
GO:0008235	metalloexopeptidase activity	3/439	72/18367	0.247232654438494	0.616558483675431	CNDP2/TFRC/CPM	3
GO:0030276	clathrin binding	3/439	72/18367	0.247232654438494	0.616558483675431	CLTB/DAB2/PIK3C2A	3
GO:0015144	carbohydrate transmembrane transporter activity	2/439	40/18367	0.247839800514118	0.616558483675431	SLC2A3/SLC2A12	2
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/439	40/18367	0.247839800514118	0.616558483675431	CYP2J2/HMOX1	2
GO:0031492	nucleosomal DNA binding	2/439	40/18367	0.247839800514118	0.616558483675431	ACTB/HNRNPC	2
GO:0042287	MHC protein binding	2/439	40/18367	0.247839800514118	0.616558483675431	CD81/TUBB4B	2
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	2/439	40/18367	0.247839800514118	0.616558483675431	SERPINB9/PRDX3	2
GO:0003964	RNA-directed DNA polymerase activity	1/439	12/18367	0.252028276101053	0.616558483675431	PTGES3	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/439	12/18367	0.252028276101053	0.616558483675431	CDK12	1
GO:0015269	calcium-activated potassium channel activity	1/439	12/18367	0.252028276101053	0.616558483675431	KCNN4	1
GO:0030955	potassium ion binding	1/439	12/18367	0.252028276101053	0.616558483675431	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/439	12/18367	0.252028276101053	0.616558483675431	P3H2	1
GO:0033130	acetylcholine receptor binding	1/439	12/18367	0.252028276101053	0.616558483675431	LY6E	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/439	12/18367	0.252028276101053	0.616558483675431	PIK3C2A	1
GO:0042975	peroxisome proliferator activated receptor binding	1/439	12/18367	0.252028276101053	0.616558483675431	TACC1	1
GO:0045295	gamma-catenin binding	1/439	12/18367	0.252028276101053	0.616558483675431	CTNNA1	1
GO:0046790	virion binding	1/439	12/18367	0.252028276101053	0.616558483675431	PPIA	1
GO:1900750	oligopeptide binding	1/439	12/18367	0.252028276101053	0.616558483675431	GSTM3	1
GO:1902936	phosphatidylinositol bisphosphate binding	4/439	107/18367	0.253301838912583	0.616558483675431	SCIN/PLEKHA5/PFN1/TTPA	4
GO:0015370	solute:sodium symporter activity	3/439	73/18367	0.253660476184904	0.616558483675431	SLC6A8/SLC13A4/SLC28A2	3
GO:0070063	RNA polymerase binding	3/439	73/18367	0.253660476184904	0.616558483675431	PABPN1/ZNF326/ANP32B	3
GO:0106306	protein serine phosphatase activity	3/439	73/18367	0.253660476184904	0.616558483675431	DUSP5/DUSP6/PPP4C	3
GO:0106307	protein threonine phosphatase activity	3/439	73/18367	0.253660476184904	0.616558483675431	DUSP5/DUSP6/PPP4C	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/439	41/18367	0.256744383851628	0.616558483675431	UBA5/SLC27A2	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/439	41/18367	0.256744383851628	0.616558483675431	COL17A1/COL21A1	2
GO:0140375	immune receptor activity	5/439	144/18367	0.261902435767444	0.616558483675431	CSF3R/ACKR2/LIFR/IL6ST/PRLR	5
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2/439	42/18367	0.265653935505443	0.616558483675431	NDUFB1/NDUFA3	2
GO:0019205	nucleobase-containing compound kinase activity	2/439	42/18367	0.265653935505443	0.616558483675431	NME1/N4BP2	2
GO:0019894	kinesin binding	2/439	42/18367	0.265653935505443	0.616558483675431	ACTB/SPAG9	2
GO:0015399	primary active transmembrane transporter activity	6/439	181/18367	0.265736482885929	0.616558483675431	UQCR10/CYB5A/NDUFB1/NDUFA3/ATP2B4/COX5B	6
GO:0016247	channel regulator activity	5/439	145/18367	0.266447045770945	0.616558483675431	CAV1/PKP2/ATP2B4/FXYD3/PRKCZ	5
GO:0060090	molecular adaptor activity	11/439	369/18367	0.26974440586972	0.616558483675431	CAV1/SYNE1/KLF4/FRMD4A/EIF3B/EIF4G1/PDCD6/PKP2/SPAG9/HERPUD1/DAB2	11
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/439	13/18367	0.269917657021328	0.616558483675431	PPP1R14B	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/439	13/18367	0.269917657021328	0.616558483675431	SLC13A4	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/439	13/18367	0.269917657021328	0.616558483675431	PRDX3	1
GO:0031404	chloride ion binding	1/439	13/18367	0.269917657021328	0.616558483675431	CTSC	1
GO:0034236	protein kinase A catalytic subunit binding	1/439	13/18367	0.269917657021328	0.616558483675431	EZR	1
GO:0052650	NADP-retinol dehydrogenase activity	1/439	13/18367	0.269917657021328	0.616558483675431	RDH13	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/439	13/18367	0.269917657021328	0.616558483675431	CCNB1	1
GO:0070679	inositol 1,4,5 trisphosphate binding	1/439	13/18367	0.269917657021328	0.616558483675431	ITPR2	1
GO:0070700	BMP receptor binding	1/439	13/18367	0.269917657021328	0.616558483675431	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/439	13/18367	0.269917657021328	0.616558483675431	HSD17B12	1
GO:0016504	peptidase activator activity	2/439	43/18367	0.274563143264143	0.622903457677494	CAV1/CTSC	2
GO:0050136	NADH dehydrogenase (quinone) activity	2/439	43/18367	0.274563143264143	0.622903457677494	NDUFB1/NDUFA3	2
GO:0008375	acetylglucosaminyltransferase activity	2/439	44/18367	0.283466944893978	0.62670382703399	B3GNT2/EXTL2	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/439	44/18367	0.283466944893978	0.62670382703399	GAPDH/HSD17B12	2
GO:0004065	arylsulfatase activity	1/439	14/18367	0.287380125614966	0.62670382703399	STS	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/439	14/18367	0.287380125614966	0.62670382703399	B3GNT2	1
GO:0015373	anion:sodium symporter activity	1/439	14/18367	0.287380125614966	0.62670382703399	SLC13A4	1
GO:0015926	glucosidase activity	1/439	14/18367	0.287380125614966	0.62670382703399	AGL	1
GO:0019992	diacylglycerol binding	1/439	14/18367	0.287380125614966	0.62670382703399	DGKD	1
GO:0043023	ribosomal large subunit binding	1/439	14/18367	0.287380125614966	0.62670382703399	NPM1	1
GO:0044548	S100 protein binding	1/439	14/18367	0.287380125614966	0.62670382703399	EZR	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/439	14/18367	0.287380125614966	0.62670382703399	HSD17B12	1
GO:0071837	HMG box domain binding	1/439	14/18367	0.287380125614966	0.62670382703399	JUN	1
GO:0003713	transcription coactivator activity	8/439	262/18367	0.290754553591849	0.62670382703399	PAGE4/NPM1/TACC1/ACTN1/FUS/TRIM24/SUB1/HMGB2	8
GO:0003954	NADH dehydrogenase activity	2/439	45/18367	0.292360519270386	0.62670382703399	NDUFB1/NDUFA3	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	2/439	45/18367	0.292360519270386	0.62670382703399	NDUFB1/NDUFA3	2
GO:0016835	carbon-oxygen lyase activity	3/439	79/18367	0.292640079581551	0.62670382703399	ENO1/TPI1/HACD3	3
GO:0046332	SMAD binding	3/439	79/18367	0.292640079581551	0.62670382703399	JUN/FOS/DAB2	3
GO:0015103	inorganic anion transmembrane transporter activity	5/439	152/18367	0.298706365853144	0.62670382703399	LRRC8D/SLC13A4/SLC22A11/FXYD3/CLIC3	5
GO:0001846	opsonin binding	1/439	15/18367	0.304425847015012	0.62670382703399	C1QBP	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/439	15/18367	0.304425847015012	0.62670382703399	SLC27A2	1
GO:0004953	icosanoid receptor activity	1/439	15/18367	0.304425847015012	0.62670382703399	HPGD	1
GO:0005161	platelet-derived growth factor receptor binding	1/439	15/18367	0.304425847015012	0.62670382703399	PDGFD	1
GO:0005452	inorganic anion exchanger activity	1/439	15/18367	0.304425847015012	0.62670382703399	SLC22A11	1
GO:0005545	1-phosphatidylinositol binding	1/439	15/18367	0.304425847015012	0.62670382703399	SCIN	1
GO:0016805	dipeptidase activity	1/439	15/18367	0.304425847015012	0.62670382703399	CNDP2	1
GO:0030548	acetylcholine receptor regulator activity	1/439	15/18367	0.304425847015012	0.62670382703399	LY6E	1
GO:0034483	heparan sulfate sulfotransferase activity	1/439	15/18367	0.304425847015012	0.62670382703399	HS6ST2	1
GO:0043138	3'-5' DNA helicase activity	1/439	15/18367	0.304425847015012	0.62670382703399	ASCC3	1
GO:0070742	C2H2 zinc finger domain binding	1/439	15/18367	0.304425847015012	0.62670382703399	SRRM2	1
GO:0099602	neurotransmitter receptor regulator activity	1/439	15/18367	0.304425847015012	0.62670382703399	LY6E	1
GO:1901611	phosphatidylglycerol binding	1/439	15/18367	0.304425847015012	0.62670382703399	MME	1
GO:0022853	active ion transmembrane transporter activity	8/439	267/18367	0.308241114139441	0.631711459641059	SLC6A8/SLC13A4/UQCR10/SLC28A2/CYB5A/SLC22A11/ATP2B4/COX5B	8
GO:0005044	scavenger receptor activity	2/439	47/18367	0.310098856048407	0.631711459641059	ACKR2/COLEC12	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	2/439	47/18367	0.310098856048407	0.631711459641059	DUSP5/DUSP6	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/439	82/18367	0.312293691313943	0.631711459641059	SCIN/PFN1/TTPA	3
GO:0004698	calcium-dependent protein kinase C activity	1/439	16/18367	0.321064744855051	0.631711459641059	PRKCZ	1
GO:0005159	insulin-like growth factor receptor binding	1/439	16/18367	0.321064744855051	0.631711459641059	INSL4	1
GO:0008191	metalloendopeptidase inhibitor activity	1/439	16/18367	0.321064744855051	0.631711459641059	TIMP3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/439	16/18367	0.321064744855051	0.631711459641059	SLC22A11	1
GO:0016208	AMP binding	1/439	16/18367	0.321064744855051	0.631711459641059	PYGL	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/439	16/18367	0.321064744855051	0.631711459641059	PIK3C2A	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/439	16/18367	0.321064744855051	0.631711459641059	MAOA	1
GO:0035497	cAMP response element binding	1/439	16/18367	0.321064744855051	0.631711459641059	JUN	1
GO:0036122	BMP binding	1/439	16/18367	0.321064744855051	0.631711459641059	GREM2	1
GO:0070403	NAD+ binding	1/439	16/18367	0.321064744855051	0.631711459641059	HPGD	1
GO:0140327	flippase activity	1/439	16/18367	0.321064744855051	0.631711459641059	ATP10D	1
GO:0043539	protein serine/threonine kinase activator activity	2/439	49/18367	0.327744087125505	0.631975955519329	CCNB1/DDX3X	2
GO:0015485	cholesterol binding	2/439	50/18367	0.336522060934582	0.631975955519329	CD81/CAV1	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	2/439	50/18367	0.336522060934582	0.631975955519329	HNRNPA3/SLC28A2	2
GO:0003951	NAD+ kinase activity	1/439	17/18367	0.337306506993825	0.631975955519329	DGKD	1
GO:0004697	protein kinase C activity	1/439	17/18367	0.337306506993825	0.631975955519329	PRKCZ	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/439	17/18367	0.337306506993825	0.631975955519329	PTPRG	1
GO:0005324	long-chain fatty acid transporter activity	1/439	17/18367	0.337306506993825	0.631975955519329	SLC27A2	1
GO:0008381	mechanosensitive ion channel activity	1/439	17/18367	0.337306506993825	0.631975955519329	TMEM150C	1
GO:0008392	arachidonic acid epoxygenase activity	1/439	17/18367	0.337306506993825	0.631975955519329	CYP2J2	1
GO:0015095	magnesium ion transmembrane transporter activity	1/439	17/18367	0.337306506993825	0.631975955519329	TUSC3	1
GO:0015116	sulfate transmembrane transporter activity	1/439	17/18367	0.337306506993825	0.631975955519329	SLC13A4	1
GO:0015278	calcium-release channel activity	1/439	17/18367	0.337306506993825	0.631975955519329	ITPR2	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/439	17/18367	0.337306506993825	0.631975955519329	PTPRG	1
GO:0030169	low-density lipoprotein particle binding	1/439	17/18367	0.337306506993825	0.631975955519329	COLEC12	1
GO:0031420	alkali metal ion binding	1/439	17/18367	0.337306506993825	0.631975955519329	PKM	1
GO:0031489	myosin V binding	1/439	17/18367	0.337306506993825	0.631975955519329	FUS	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/439	17/18367	0.337306506993825	0.631975955519329	B3GNT2	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	4/439	124/18367	0.344500177399711	0.641482106493255	EGFR/CLK1/NRP2/MET	4
GO:0005253	anion channel activity	3/439	87/18367	0.3450976792438	0.641482106493255	LRRC8D/FXYD3/CLIC3	3
GO:0016860	intramolecular oxidoreductase activity	2/439	51/18367	0.345265481605815	0.641482106493255	TPI1/PTGES3	2
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/439	18/18367	0.353160591104436	0.645078279470438	HSD17B12	1
GO:0004550	nucleoside diphosphate kinase activity	1/439	18/18367	0.353160591104436	0.645078279470438	NME1	1
GO:0016755	aminoacyltransferase activity	1/439	18/18367	0.353160591104436	0.645078279470438	TGM2	1
GO:0046624	sphingolipid transporter activity	1/439	18/18367	0.353160591104436	0.645078279470438	ATP10D	1
GO:0098641	cadherin binding involved in cell-cell adhesion	1/439	18/18367	0.353160591104436	0.645078279470438	ANXA1	1
GO:1904047	S-adenosyl-L-methionine binding	1/439	18/18367	0.353160591104436	0.645078279470438	METTL17	1
GO:0017046	peptide hormone binding	2/439	52/18367	0.353970989934303	0.645078279470438	SLC40A1/PRLR	2
GO:0043178	alcohol binding	3/439	89/18367	0.358191664581832	0.650991390398044	CD81/CAV1/ITPR2	3
GO:0042277	peptide binding	9/439	321/18367	0.360828783890144	0.652202561001648	SLC40A1/ITM2B/HSP90AB1/CLTB/PPIA/MME/KPNA2/PRLR/GSTM3	9
GO:0050661	NADP binding	2/439	53/18367	0.362635406276453	0.652202561001648	GAPDH/IDH1	2
GO:0042393	histone binding	7/439	244/18367	0.366184162415747	0.652202561001648	MORC4/NPM1/TRIM24/NAP1L4/ANP32B/CHD2/ZMYND8	7
GO:0000339	RNA cap binding	1/439	19/18367	0.368636230131366	0.652202561001648	EIF4A1	1
GO:0003746	translation elongation factor activity	1/439	19/18367	0.368636230131366	0.652202561001648	EIF5A	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/439	19/18367	0.368636230131366	0.652202561001648	GALNT11	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/439	19/18367	0.368636230131366	0.652202561001648	SLC28A2	1
GO:0010314	phosphatidylinositol-5-phosphate binding	1/439	19/18367	0.368636230131366	0.652202561001648	PLEKHA5	1
GO:0035615	clathrin adaptor activity	1/439	19/18367	0.368636230131366	0.652202561001648	DAB2	1
GO:0052742	phosphatidylinositol kinase activity	1/439	19/18367	0.368636230131366	0.652202561001648	PIK3C2A	1
GO:0005544	calcium-dependent phospholipid binding	2/439	54/18367	0.371255723919403	0.652698068768515	ANXA1/ANXA4	2
GO:0015459	potassium channel regulator activity	2/439	54/18367	0.371255723919403	0.652698068768515	CAV1/PRKCZ	2
GO:0015078	proton transmembrane transporter activity	4/439	130/18367	0.377118451728836	0.652698068768515	UQCR10/CYB5A/ATP6V1B1/COX5B	4
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	5/439	170/18367	0.383696913770414	0.652698068768515	CYP2J2/CYP11A1/MICAL3/P3H2/HMOX1	5
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/439	20/18367	0.383742437618413	0.652698068768515	NOP58	1
GO:0016018	cyclosporin A binding	1/439	20/18367	0.383742437618413	0.652698068768515	PPIA	1
GO:0016500	protein-hormone receptor activity	1/439	20/18367	0.383742437618413	0.652698068768515	LGR5	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/439	20/18367	0.383742437618413	0.652698068768515	CTSC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/439	20/18367	0.383742437618413	0.652698068768515	MAOA	1
GO:0030506	ankyrin binding	1/439	20/18367	0.383742437618413	0.652698068768515	NRCAM	1
GO:0031418	L-ascorbic acid binding	1/439	20/18367	0.383742437618413	0.652698068768515	P3H2	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/439	20/18367	0.383742437618413	0.652698068768515	KLF4	1
GO:0042288	MHC class I protein binding	1/439	20/18367	0.383742437618413	0.652698068768515	TUBB4B	1
GO:0140312	cargo adaptor activity	1/439	20/18367	0.383742437618413	0.652698068768515	DAB2	1
GO:0072341	modified amino acid binding	3/439	93/18367	0.384255658646207	0.652698068768515	SCIN/MME/GSTM3	3
GO:0046982	protein heterodimerization activity	9/439	328/18367	0.384573224926576	0.652698068768515	CAV1/DGKD/ADRB1/ATF3/ITGB1/CEBPB/MCL1/TOP2A/TPM1	9
GO:0030374	nuclear receptor coactivator activity	2/439	56/18367	0.38835286261256	0.657439998382177	TACC1/ACTN1	2
GO:0005201	extracellular matrix structural constituent	5/439	172/18367	0.393185438245205	0.661172897043187	FBN1/COL17A1/LAMC2/FBN2/COL21A1	5
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	2/439	57/18367	0.396824478162369	0.661172897043187	NDUFB1/NDUFA3	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	2/439	57/18367	0.396824478162369	0.661172897043187	PRDX3/PCYOX1	2
GO:1901981	phosphatidylinositol phosphate binding	5/439	173/18367	0.39792568535828	0.661172897043187	SCIN/PHLDA2/PLEKHA5/PFN1/TTPA	5
GO:0001848	complement binding	1/439	21/18367	0.398488012910587	0.661172897043187	C1QBP	1
GO:0008391	arachidonic acid monooxygenase activity	1/439	21/18367	0.398488012910587	0.661172897043187	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/439	21/18367	0.398488012910587	0.661172897043187	ATP2B4	1
GO:0140358	P-type transmembrane transporter activity	1/439	21/18367	0.398488012910587	0.661172897043187	ATP2B4	1
GO:0004721	phosphoprotein phosphatase activity	5/439	174/18367	0.402662377423998	0.665198046708657	UBASH3B/PTPRG/DUSP5/DUSP6/PPP4C	5
GO:0043177	organic acid binding	4/439	135/18367	0.404192040665485	0.665198046708657	HBB/P3H2/HBG1/HBG2	4
GO:0004713	protein tyrosine kinase activity	4/439	136/18367	0.409583328407904	0.665198046708657	EGFR/CLK1/NRP2/MET	4
GO:0030674	protein-macromolecule adaptor activity	8/439	296/18367	0.412627456181561	0.665198046708657	CAV1/SYNE1/KLF4/FRMD4A/PDCD6/SPAG9/HERPUD1/DAB2	8
GO:0005540	hyaluronic acid binding	1/439	22/18367	0.41288154623296	0.665198046708657	C1QBP	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/439	22/18367	0.41288154623296	0.665198046708657	RDH13	1
GO:0008320	protein transmembrane transporter activity	1/439	22/18367	0.41288154623296	0.665198046708657	MCL1	1
GO:0009975	cyclase activity	1/439	22/18367	0.41288154623296	0.665198046708657	ADCY7	1
GO:0015296	anion:cation symporter activity	1/439	22/18367	0.41288154623296	0.665198046708657	SLC13A4	1
GO:0015645	fatty acid ligase activity	1/439	22/18367	0.41288154623296	0.665198046708657	SLC27A2	1
GO:0033691	sialic acid binding	1/439	22/18367	0.41288154623296	0.665198046708657	SIGLEC6	1
GO:0072349	modified amino acid transmembrane transporter activity	1/439	22/18367	0.41288154623296	0.665198046708657	SLC6A8	1
GO:0005525	GTP binding	10/439	377/18367	0.414014859172495	0.665416653176034	ARF5/RHOB/HSP90AB1/GNL3/NME1/RHOV/TGM2/TUBA1C/ARF4/TUBB4B	10
GO:0004722	protein serine/threonine phosphatase activity	3/439	98/18367	0.416474431463721	0.667760686986302	DUSP5/DUSP6/PPP4C	3
GO:0001786	phosphatidylserine binding	2/439	60/18367	0.421903395969645	0.66845835580779	SCIN/MME	2
GO:0032934	sterol binding	2/439	60/18367	0.421903395969645	0.66845835580779	CD81/CAV1	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/439	23/18367	0.426931423649353	0.66845835580779	PRKCZ	1
GO:0016493	C-C chemokine receptor activity	1/439	23/18367	0.426931423649353	0.66845835580779	ACKR2	1
GO:0016849	phosphorus-oxygen lyase activity	1/439	23/18367	0.426931423649353	0.66845835580779	ADCY7	1
GO:0019865	immunoglobulin binding	1/439	23/18367	0.426931423649353	0.66845835580779	LGALS3	1
GO:0030215	semaphorin receptor binding	1/439	23/18367	0.426931423649353	0.66845835580779	SEMA6D	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/439	23/18367	0.426931423649353	0.66845835580779	ABHD8	1
GO:0050750	low-density lipoprotein particle receptor binding	1/439	23/18367	0.426931423649353	0.66845835580779	DNAJA1	1
GO:0071617	lysophospholipid acyltransferase activity	1/439	23/18367	0.426931423649353	0.66845835580779	ABHD8	1
GO:0005507	copper ion binding	2/439	61/18367	0.430144064135991	0.671911219622262	F5/SNCG	2
GO:0030295	protein kinase activator activity	3/439	101/18367	0.43554553651861	0.675656942252356	RPLP1/CCNB1/DDX3X	3
GO:0070851	growth factor receptor binding	4/439	141/18367	0.436373595073896	0.675656942252356	PDGFD/IL6ST/ARF4/VAV3	4
GO:0010857	calcium-dependent protein kinase activity	1/439	24/18367	0.44064583190371	0.675656942252356	PRKCZ	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/439	24/18367	0.44064583190371	0.675656942252356	GAPDH	1
GO:0019789	SUMO transferase activity	1/439	24/18367	0.44064583190371	0.675656942252356	UBE2I	1
GO:0019957	C-C chemokine binding	1/439	24/18367	0.44064583190371	0.675656942252356	ACKR2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/439	24/18367	0.44064583190371	0.675656942252356	BMP7	1
GO:0070840	dynein complex binding	1/439	24/18367	0.44064583190371	0.675656942252356	CENPF	1
GO:0005085	guanyl-nucleotide exchange factor activity	6/439	223/18367	0.442766265766558	0.677351145106179	ADRB1/EPS8L1/C9orf72/ARF4/VAV3/DOCK5	6
GO:0019199	transmembrane receptor protein kinase activity	4/439	143/18367	0.446996623716553	0.681214434563993	EGFR/CLK1/NRP2/MET	4
GO:0031490	chromatin DNA binding	3/439	103/18367	0.448130261424527	0.681214434563993	GRHL1/ACTB/HNRNPC	3
GO:0005112	Notch binding	1/439	25/18367	0.454032763146924	0.681214434563993	GALNT11	1
GO:0005227	calcium activated cation channel activity	1/439	25/18367	0.454032763146924	0.681214434563993	KCNN4	1
GO:0008327	methyl-CpG binding	1/439	25/18367	0.454032763146924	0.681214434563993	DNMT1	1
GO:0030247	polysaccharide binding	1/439	25/18367	0.454032763146924	0.681214434563993	AGL	1
GO:0034237	protein kinase A regulatory subunit binding	1/439	25/18367	0.454032763146924	0.681214434563993	EZR	1
GO:0015294	solute:cation symporter activity	3/439	104/18367	0.45438039095569	0.681214434563993	SLC6A8/SLC13A4/SLC28A2	3
GO:0016836	hydro-lyase activity	2/439	64/18367	0.454483393374778	0.681214434563993	ENO1/HACD3	2
GO:0001637	G protein-coupled chemoattractant receptor activity	1/439	26/18367	0.467100019551815	0.687493084974357	ACKR2	1
GO:0004364	glutathione transferase activity	1/439	26/18367	0.467100019551815	0.687493084974357	GSTM3	1
GO:0004950	chemokine receptor activity	1/439	26/18367	0.467100019551815	0.687493084974357	ACKR2	1
GO:0038187	pattern recognition receptor activity	1/439	26/18367	0.467100019551815	0.687493084974357	COLEC12	1
GO:0099604	ligand-gated calcium channel activity	1/439	26/18367	0.467100019551815	0.687493084974357	ITPR2	1
GO:0008017	microtubule binding	7/439	271/18367	0.471348652690066	0.687493084974357	GAPDH/CCSAP/CAPN6/EZR/FMN1/CENPF/REEP3	7
GO:0035091	phosphatidylinositol binding	7/439	271/18367	0.471348652690066	0.687493084974357	SCIN/PHLDA2/ITPR2/PLEKHA5/PFN1/PIK3C2A/TTPA	7
GO:0019209	kinase activator activity	3/439	107/18367	0.472949205114448	0.687493084974357	RPLP1/CCNB1/DDX3X	3
GO:0019842	vitamin binding	4/439	148/18367	0.47326741005713	0.687493084974357	P3H2/PYGL/TKT/TTPA	4
GO:0008237	metallopeptidase activity	5/439	190/18367	0.477466430784661	0.687493084974357	ADAMTS6/CNDP2/TFRC/CPM/MME	5
GO:0004709	MAP kinase kinase kinase activity	1/439	27/18367	0.479855217818907	0.687493084974357	EGFR	1
GO:0008139	nuclear localization sequence binding	1/439	27/18367	0.479855217818907	0.687493084974357	KPNA2	1
GO:0016405	CoA-ligase activity	1/439	27/18367	0.479855217818907	0.687493084974357	SLC27A2	1
GO:0016866	intramolecular transferase activity	1/439	27/18367	0.479855217818907	0.687493084974357	CYP2J2	1
GO:0035255	ionotropic glutamate receptor binding	1/439	27/18367	0.479855217818907	0.687493084974357	FUS	1
GO:0043425	bHLH transcription factor binding	1/439	27/18367	0.479855217818907	0.687493084974357	ISL1	1
GO:0045499	chemorepellent activity	1/439	27/18367	0.479855217818907	0.687493084974357	SEMA6D	1
GO:0051393	alpha-actinin binding	1/439	27/18367	0.479855217818907	0.687493084974357	DAG1	1
GO:0051959	dynein light intermediate chain binding	1/439	27/18367	0.479855217818907	0.687493084974357	DYNLL1	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/439	27/18367	0.479855217818907	0.687493084974357	ATP10D	1
GO:0019001	guanyl nucleotide binding	10/439	398/18367	0.481348231908583	0.687493084974357	ARF5/RHOB/HSP90AB1/GNL3/NME1/RHOV/TGM2/TUBA1C/ARF4/TUBB4B	10
GO:0032561	guanyl ribonucleotide binding	10/439	398/18367	0.481348231908583	0.687493084974357	ARF5/RHOB/HSP90AB1/GNL3/NME1/RHOV/TGM2/TUBA1C/ARF4/TUBB4B	10
GO:0005506	iron ion binding	4/439	151/18367	0.488805038094829	0.695694839650247	CYP2J2/CYP11A1/P3H2/ABCE1	4
GO:0017056	structural constituent of nuclear pore	1/439	28/18367	0.492305793575587	0.695694839650247	NUTF2	1
GO:0046875	ephrin receptor binding	1/439	28/18367	0.492305793575587	0.695694839650247	EFNB1	1
GO:0070325	lipoprotein particle receptor binding	1/439	28/18367	0.492305793575587	0.695694839650247	DNAJA1	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	1/439	28/18367	0.492305793575587	0.695694839650247	PLEKHA5	1
GO:0048018	receptor ligand activity	12/439	487/18367	0.49857428787152	0.699948541834044	CSH1/GREM2/FBN1/FAM3B/HDGF/SEMA6D/BMP7/PDGFD/INSL4/LGALS3/CMTM8/HMGB2	12
GO:0001098	basal transcription machinery binding	2/439	70/18367	0.501308248821931	0.699948541834044	ZNF326/NOP58	2
GO:0001099	basal RNA polymerase II transcription machinery binding	2/439	70/18367	0.501308248821931	0.699948541834044	ZNF326/NOP58	2
GO:0004033	aldo-keto reductase (NADP) activity	1/439	29/18367	0.504459005671139	0.699948541834044	RDH13	1
GO:0004181	metallocarboxypeptidase activity	1/439	29/18367	0.504459005671139	0.699948541834044	CPM	1
GO:0033612	receptor serine/threonine kinase binding	1/439	29/18367	0.504459005671139	0.699948541834044	BMP7	1
GO:0035250	UDP-galactosyltransferase activity	1/439	29/18367	0.504459005671139	0.699948541834044	B3GNT2	1
GO:0070273	phosphatidylinositol-4-phosphate binding	1/439	29/18367	0.504459005671139	0.699948541834044	PLEKHA5	1
GO:0016829	lyase activity	5/439	196/18367	0.504760492686919	0.699948541834044	ALDOA/ENO1/TPI1/HACD3/ADCY7	5
GO:0022804	active transmembrane transporter activity	10/439	406/18367	0.506620544258739	0.701070338216969	SLC6A8/SLC13A4/UQCR10/SLC28A2/CYB5A/SLC22A11/NDUFB1/NDUFA3/ATP2B4/COX5B	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/439	71/18367	0.508858319310716	0.701805346657958	ASAH1/TGM2	2
GO:0016758	hexosyltransferase activity	5/439	197/18367	0.509256053646854	0.701805346657958	GALNT11/B3GNT2/AGL/PYGL/EXTL2	5
GO:0005217	intracellular ligand-gated ion channel activity	1/439	30/18367	0.516321940370145	0.707159618535701	ITPR2	1
GO:0017147	Wnt-protein binding	1/439	30/18367	0.516321940370145	0.707159618535701	WLS	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/439	30/18367	0.516321940370145	0.707159618535701	HSD17B12	1
GO:0030546	signaling receptor activator activity	12/439	495/18367	0.521438023756185	0.709899820167141	CSH1/GREM2/FBN1/FAM3B/HDGF/SEMA6D/BMP7/PDGFD/INSL4/LGALS3/CMTM8/HMGB2	12
GO:0035064	methylated histone binding	2/439	73/18367	0.523732573859802	0.709899820167141	MORC4/ZMYND8	2
GO:0140034	methylation-dependent protein binding	2/439	73/18367	0.523732573859802	0.709899820167141	MORC4/ZMYND8	2
GO:0005516	calmodulin binding	5/439	201/18367	0.527069895769948	0.709899820167141	EGFR/EWSR1/KCNN4/ATP2B4/ADD3	5
GO:0008157	protein phosphatase 1 binding	1/439	31/18367	0.527901515446629	0.709899820167141	PPP1R15A	1
GO:0016878	acid-thiol ligase activity	1/439	31/18367	0.527901515446629	0.709899820167141	SLC27A2	1
GO:0071813	lipoprotein particle binding	1/439	31/18367	0.527901515446629	0.709899820167141	COLEC12	1
GO:0071814	protein-lipid complex binding	1/439	31/18367	0.527901515446629	0.709899820167141	COLEC12	1
GO:0090482	vitamin transmembrane transporter activity	1/439	31/18367	0.527901515446629	0.709899820167141	SLC2A3	1
GO:0005254	chloride channel activity	2/439	74/18367	0.531055371632266	0.712704090299239	FXYD3/CLIC3	2
GO:0140030	modification-dependent protein binding	4/439	160/18367	0.534216221785441	0.713590061406602	MORC4/AGL/TRIM24/ZMYND8	4
GO:0001222	transcription corepressor binding	1/439	32/18367	0.5392044841813	0.713590061406602	HDGF	1
GO:0001223	transcription coactivator binding	1/439	32/18367	0.5392044841813	0.713590061406602	RPL23	1
GO:0008378	galactosyltransferase activity	1/439	32/18367	0.5392044841813	0.713590061406602	B3GNT2	1
GO:0030332	cyclin binding	1/439	32/18367	0.5392044841813	0.713590061406602	CDK12	1
GO:0071889	14-3-3 protein binding	1/439	32/18367	0.5392044841813	0.713590061406602	PRKCZ	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/439	32/18367	0.5392044841813	0.713590061406602	CHD2	1
GO:0008083	growth factor activity	4/439	162/18367	0.544035146359486	0.718557312122331	CSH1/HDGF/BMP7/PDGFD	4
GO:0008200	ion channel inhibitor activity	1/439	33/18367	0.55023743926417	0.723882390511245	CAV1	1
GO:0051427	hormone receptor binding	1/439	33/18367	0.55023743926417	0.723882390511245	CSH1	1
GO:0005179	hormone activity	3/439	122/18367	0.560972926383922	0.730842864600388	CSH1/FBN1/INSL4	3
GO:0001664	G protein-coupled receptor binding	7/439	295/18367	0.560983322415126	0.730842864600388	HSPA1A/HSPA1B/WLS/ADRB1/DNAJA1/C1QBP/ARRDC3	7
GO:0016229	steroid dehydrogenase activity	1/439	34/18367	0.561006816604796	0.730842864600388	HSD17B12	1
GO:0016248	channel inhibitor activity	1/439	34/18367	0.561006816604796	0.730842864600388	CAV1	1
GO:0045505	dynein intermediate chain binding	1/439	34/18367	0.561006816604796	0.730842864600388	DYNLL1	1
GO:0046873	metal ion transmembrane transporter activity	10/439	430/18367	0.579997249290816	0.752029341004473	SLC6A8/SLC40A1/SLC13A4/SLC25A37/TUSC3/ITPR2/SLC28A2/TMEM37/KCNN4/ATP2B4	10
GO:0034061	DNA polymerase activity	1/439	36/18367	0.581779820027449	0.752029341004473	PTGES3	1
GO:0042805	actinin binding	1/439	36/18367	0.581779820027449	0.752029341004473	DAG1	1
GO:0061631	ubiquitin conjugating enzyme activity	1/439	36/18367	0.581779820027449	0.752029341004473	UBE2J1	1
GO:0043531	ADP binding	1/439	37/18367	0.591795567068415	0.762022477286936	CHORDC1	1
GO:0071949	FAD binding	1/439	37/18367	0.591795567068415	0.762022477286936	MICAL3	1
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	1/439	38/18367	0.601571985293017	0.771631758058544	PPIA	1
GO:0140303	intramembrane lipid transporter activity	1/439	38/18367	0.601571985293017	0.771631758058544	ATP10D	1
GO:0008013	beta-catenin binding	2/439	85/18367	0.606442503708238	0.774898754738304	KLF4/CTNNA1	2
GO:0050660	flavin adenine dinucleotide binding	2/439	85/18367	0.606442503708238	0.774898754738304	MICAL3/MAOA	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	1/439	39/18367	0.611114780778661	0.776406778627366	POLR2L	1
GO:0016776	phosphotransferase activity, phosphate group as acceptor	1/439	39/18367	0.611114780778661	0.776406778627366	NME1	1
GO:0050997	quaternary ammonium group binding	1/439	39/18367	0.611114780778661	0.776406778627366	TKT	1
GO:0033218	amide binding	9/439	400/18367	0.620004377129485	0.782280704000376	SLC40A1/ITM2B/HSP90AB1/CLTB/PPIA/MME/KPNA2/PRLR/GSTM3	9
GO:0004177	aminopeptidase activity	1/439	40/18367	0.620429523862367	0.782280704000376	DPP7	1
GO:0042169	SH2 domain binding	1/439	40/18367	0.620429523862367	0.782280704000376	DAG1	1
GO:0043014	alpha-tubulin binding	1/439	40/18367	0.620429523862367	0.782280704000376	HSPH1	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	2/439	88/18367	0.625340762724493	0.784986563473822	NDUFB1/NDUFA3	2
GO:0051219	phosphoprotein binding	2/439	88/18367	0.625340762724493	0.784986563473822	UBASH3B/PFN1	2
GO:0008509	anion transmembrane transporter activity	7/439	314/18367	0.626797015359406	0.784986563473822	LRRC8D/SLC2A3/SLC6A8/SLC13A4/SLC22A11/FXYD3/CLIC3	7
GO:0016859	cis-trans isomerase activity	1/439	41/18367	0.629521652362636	0.784986563473822	PPIA	1
GO:0048487	beta-tubulin binding	1/439	41/18367	0.629521652362636	0.784986563473822	EMD	1
GO:0015085	calcium ion transmembrane transporter activity	3/439	135/18367	0.629636898738373	0.784986563473822	ITPR2/TMEM37/ATP2B4	3
GO:0051539	4 iron, 4 sulfur cluster binding	1/439	42/18367	0.638396474725006	0.794422478808916	ABCE1	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/439	43/18367	0.647059173093122	0.796288687182865	MICAL3	1
GO:0030544	Hsp70 protein binding	1/439	43/18367	0.647059173093122	0.796288687182865	DNAJA1	1
GO:0030547	signaling receptor inhibitor activity	1/439	43/18367	0.647059173093122	0.796288687182865	LY6E	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/439	43/18367	0.647059173093122	0.796288687182865	PLEKHA5	1
GO:0034062	5'-3' RNA polymerase activity	1/439	43/18367	0.647059173093122	0.796288687182865	POLR2L	1
GO:0097747	RNA polymerase activity	1/439	43/18367	0.647059173093122	0.796288687182865	POLR2L	1
GO:0043130	ubiquitin binding	2/439	92/18367	0.649434943959678	0.797740529688961	N4BP2/TOP2A	2
GO:0001784	phosphotyrosine residue binding	1/439	44/18367	0.655514806307056	0.800784571074737	PFN1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/439	44/18367	0.655514806307056	0.800784571074737	CLK1	1
GO:0022839	ion gated channel activity	1/439	44/18367	0.655514806307056	0.800784571074737	KCNN4	1
GO:0016410	N-acyltransferase activity	2/439	94/18367	0.661013638300027	0.806025771016669	SAT1/TGM2	2
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1/439	45/18367	0.663768312830617	0.807907782222667	CLK1	1
GO:0008194	UDP-glycosyltransferase activity	3/439	143/18367	0.668042264685398	0.811628762377341	GALNT11/B3GNT2/EXTL2	3
GO:0005096	GTPase activator activity	10/439	462/18367	0.669552601571965	0.811801829479828	JUN/ERRFI1/ADRB1/EPS8L1/HACD3/C9orf72/ARHGAP28/ARF4/VAV3/DOCK5	10
GO:0140296	general transcription initiation factor binding	1/439	46/18367	0.671824513609318	0.811801829479828	NOP58	1
GO:0015293	symporter activity	3/439	144/18367	0.672632844166225	0.811801829479828	SLC6A8/SLC13A4/SLC28A2	3
GO:0008236	serine-type peptidase activity	4/439	191/18367	0.673053091008013	0.811801829479828	DPP7/CPVL/CTSC/HTRA1	4
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/439	47/18367	0.679688114860642	0.814212935947678	ATP2B4	1
GO:0035254	glutamate receptor binding	1/439	47/18367	0.679688114860642	0.814212935947678	FUS	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/439	47/18367	0.679688114860642	0.814212935947678	ADRB1	1
GO:0005543	phospholipid binding	10/439	466/18367	0.679934940514028	0.814212935947678	ANXA1/SCIN/ANXA4/PHLDA2/ITPR2/PLEKHA5/PFN1/MME/PIK3C2A/TTPA	10
GO:0015026	coreceptor activity	1/439	48/18367	0.687363710798206	0.818699276968577	ITGB1	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	1/439	48/18367	0.687363710798206	0.818699276968577	RIMKLB	1
GO:0120013	lipid transfer activity	1/439	48/18367	0.687363710798206	0.818699276968577	TTPA	1
GO:0017171	serine hydrolase activity	4/439	195/18367	0.688718467528252	0.818850655688671	DPP7/CPVL/CTSC/HTRA1	4
GO:0005496	steroid binding	2/439	100/18367	0.693911200725302	0.823556531821666	CD81/CAV1	2
GO:0003924	GTPase activity	7/439	337/18367	0.698559684832303	0.82746737788182	ARF5/RHOB/RHOV/TUBA1C/DDX3X/ARF4/TUBB4B	7
GO:0000993	RNA polymerase II complex binding	1/439	50/18367	0.702168719461934	0.82746737788182	ZNF326	1
GO:0005048	signal sequence binding	1/439	50/18367	0.702168719461934	0.82746737788182	KPNA2	1
GO:0030159	signaling receptor complex adaptor activity	1/439	50/18367	0.702168719461934	0.82746737788182	SPAG9	1
GO:0004674	protein serine/threonine kinase activity	8/439	386/18367	0.707518120462764	0.830013377323002	EGFR/CDK12/CLK1/CSNK1E/TOP1/PRKCZ/CDKL5/TLK1	8
GO:0015081	sodium ion transmembrane transporter activity	3/439	152/18367	0.707679956676346	0.830013377323002	SLC6A8/SLC13A4/SLC28A2	3
GO:0008227	G protein-coupled amine receptor activity	1/439	51/18367	0.709306784219057	0.830013377323002	ADRB1	1
GO:0051018	protein kinase A binding	1/439	51/18367	0.709306784219057	0.830013377323002	EZR	1
GO:0005319	lipid transporter activity	3/439	154/18367	0.715978861272629	0.830878017171955	SLC27A2/ATP10D/TTPA	3
GO:0008146	sulfotransferase activity	1/439	52/18367	0.716274152734444	0.830878017171955	HS6ST2	1
GO:0016830	carbon-carbon lyase activity	1/439	52/18367	0.716274152734444	0.830878017171955	ALDOA	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/439	52/18367	0.716274152734444	0.830878017171955	AGL	1
GO:1901682	sulfur compound transmembrane transporter activity	1/439	52/18367	0.716274152734444	0.830878017171955	SLC13A4	1
GO:1990782	protein tyrosine kinase binding	2/439	105/18367	0.719274989036303	0.832910447373636	EIF3A/ITGB1	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/439	53/18367	0.723074897858636	0.835859543971768	SLC28A2	1
GO:0008374	O-acyltransferase activity	1/439	54/18367	0.729712995480131	0.840619288402845	CROT	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/439	54/18367	0.729712995480131	0.840619288402845	P3H2	1
GO:0030695	GTPase regulator activity	10/439	488/18367	0.733465549447507	0.842033599796019	JUN/ERRFI1/ADRB1/EPS8L1/HACD3/C9orf72/ARHGAP28/ARF4/VAV3/DOCK5	10
GO:0060589	nucleoside-triphosphatase regulator activity	10/439	488/18367	0.733465549447507	0.842033599796019	JUN/ERRFI1/ADRB1/EPS8L1/HACD3/C9orf72/ARHGAP28/ARF4/VAV3/DOCK5	10
GO:0030170	pyridoxal phosphate binding	1/439	55/18367	0.736192326828584	0.843711824733103	PYGL	1
GO:0045309	protein phosphorylated amino acid binding	1/439	56/18367	0.742516680723421	0.848045592538565	PFN1	1
GO:0070279	vitamin B6 binding	1/439	56/18367	0.742516680723421	0.848045592538565	PYGL	1
GO:0004222	metalloendopeptidase activity	2/439	111/18367	0.747354329646429	0.849279025676915	ADAMTS6/MME	2
GO:0032182	ubiquitin-like protein binding	2/439	111/18367	0.747354329646429	0.849279025676915	N4BP2/TOP2A	2
GO:0004536	deoxyribonuclease activity	1/439	57/18367	0.748689755769154	0.849279025676915	NME1	1
GO:0043175	RNA polymerase core enzyme binding	1/439	57/18367	0.748689755769154	0.849279025676915	ZNF326	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	1/439	58/18367	0.754715162498665	0.853211887095948	SLC27A2	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/439	58/18367	0.754715162498665	0.853211887095948	GSTM3	1
GO:0016874	ligase activity	3/439	165/18367	0.758388268214541	0.855913663111842	UBA5/RIMKLB/SLC27A2	3
GO:0106310	protein serine kinase activity	7/439	360/18367	0.760702446735429	0.857075222926573	CDK12/CLK1/CSNK1E/PRPF4B/PRKCZ/CDKL5/TLK1	7
GO:0001217	DNA-binding transcription repressor activity	6/439	313/18367	0.762137836157755	0.857244412676598	JUN/ENO1/ZNF175/ATF3/SOX6/CEBPB	6
GO:0043621	protein self-association	1/439	61/18367	0.771940200640175	0.866808272436021	CTSC	1
GO:0016757	glycosyltransferase activity	5/439	270/18367	0.776503361131898	0.869681402748405	GALNT11/B3GNT2/AGL/PYGL/EXTL2	5
GO:0098960	postsynaptic neurotransmitter receptor activity	1/439	62/18367	0.777409350204195	0.869681402748405	ADRB1	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4/439	222/18367	0.780511260284436	0.869681402748405	SAT1/ABHD8/TGM2/CROT	4
GO:0004197	cysteine-type endopeptidase activity	2/439	119/18367	0.781018231253815	0.869681402748405	LGMN/CTSC	2
GO:0005262	calcium channel activity	2/439	119/18367	0.781018231253815	0.869681402748405	ITPR2/TMEM37	2
GO:0016791	phosphatase activity	5/439	275/18367	0.789843452860146	0.878042638429529	UBASH3B/PTPRG/DUSP5/DUSP6/PPP4C	5
GO:0030145	manganese ion binding	1/439	65/18367	0.793044030660788	0.880133724543669	EXTL2	1
GO:0031406	carboxylic acid binding	3/439	176/18367	0.79554050251697	0.881437732855181	P3H2/SIGLEC6/PYGL	3
GO:0002039	p53 binding	1/439	66/18367	0.798008169582212	0.882705554081817	TRIM24	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/439	125/18367	0.803625241038811	0.885950278481868	ASAH1/TGM2	2
GO:0003684	damaged DNA binding	1/439	68/18367	0.807582862544191	0.885950278481868	HMGB2	1
GO:0008080	N-acetyltransferase activity	1/439	68/18367	0.807582862544191	0.885950278481868	SAT1	1
GO:0051536	iron-sulfur cluster binding	1/439	68/18367	0.807582862544191	0.885950278481868	ABCE1	1
GO:0051540	metal cluster binding	1/439	68/18367	0.807582862544191	0.885950278481868	ABCE1	1
GO:0005125	cytokine activity	4/439	235/18367	0.816379722155621	0.892451703362146	GREM2/FAM3B/BMP7/CMTM8	4
GO:0004860	protein kinase inhibitor activity	1/439	70/18367	0.8167046865692	0.892451703362146	NPM1	1
GO:0016298	lipase activity	2/439	129/18367	0.817523224519147	0.892451703362146	HMOX1/LIPA	2
GO:0008514	organic anion transmembrane transporter activity	3/439	185/18367	0.822285568469679	0.896183781322346	SLC2A3/SLC6A8/SLC22A11	3
GO:0000049	tRNA binding	1/439	72/18367	0.825395015104605	0.898105179567327	RPL35A	1
GO:0016779	nucleotidyltransferase activity	2/439	132/18367	0.827362821770556	0.898267925994179	PTGES3/POLR2L	2
GO:0015291	secondary active transmembrane transporter activity	4/439	240/18367	0.828834569934238	0.898267925994179	SLC6A8/SLC13A4/SLC28A2/SLC22A11	4
GO:0033293	monocarboxylic acid binding	1/439	73/18367	0.829584771233005	0.898267925994179	PYGL	1
GO:0017022	myosin binding	1/439	74/18367	0.833674215063152	0.898321003953348	FUS	1
GO:0019210	kinase inhibitor activity	1/439	74/18367	0.833674215063152	0.898321003953348	NPM1	1
GO:0019905	syntaxin binding	1/439	74/18367	0.833674215063152	0.898321003953348	TMED9	1
GO:0019003	GDP binding	1/439	75/18367	0.837665742947439	0.901166210557971	RHOB	1
GO:0030971	receptor tyrosine kinase binding	1/439	78/18367	0.849075945791358	0.911970460294422	EIF3A	1
GO:0016746	acyltransferase activity	4/439	250/18367	0.85164514781268	0.913259346609418	SAT1/ABHD8/TGM2/CROT	4
GO:0035591	signaling adaptor activity	1/439	81/18367	0.859685842684818	0.920402017770102	SPAG9	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	5/439	310/18367	0.866497581173419	0.92522510951367	JUN/ENO1/ZNF175/ATF3/CEBPB	5
GO:0001540	amyloid-beta binding	1/439	84/18367	0.869551447547956	0.92522510951367	ITM2B	1
GO:0008528	G protein-coupled peptide receptor activity	2/439	147/18367	0.869739345824694	0.92522510951367	ACKR2/LGR5	2
GO:0052689	carboxylic ester hydrolase activity	2/439	147/18367	0.869739345824694	0.92522510951367	ABHD8/LIPA	2
GO:0042578	phosphoric ester hydrolase activity	6/439	366/18367	0.873706672416078	0.927965526276312	UBASH3B/PTPRG/HMOX1/DUSP5/DUSP6/PPP4C	6
GO:0140677	molecular function activator activity	2/439	150/18367	0.876977056377903	0.929958182200415	DNAJB6/DNAJA1	2
GO:0001653	peptide receptor activity	2/439	153/18367	0.883842713366328	0.934941612099038	ACKR2/LGR5	2
GO:0008081	phosphoric diester hydrolase activity	1/439	89/18367	0.884479995853813	0.934941612099038	HMOX1	1
GO:0016407	acetyltransferase activity	1/439	91/18367	0.889962611177451	0.939066325175443	SAT1	1
GO:0005126	cytokine receptor binding	4/439	271/18367	0.89126299375536	0.939066325175443	CSH1/LIFR/IL6ST/PRLR	4
GO:0051213	dioxygenase activity	1/439	92/18367	0.892605772355668	0.939066325175443	P3H2	1
GO:0005216	ion channel activity	7/439	432/18367	0.894744839196777	0.939834342904331	LRRC8D/ITPR2/TMEM37/KCNN4/FXYD3/CLIC3/TMEM150C	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	1/439	94/18367	0.897703562360721	0.941459553607863	AGL	1
GO:0022836	gated channel activity	5/439	340/18367	0.912076428979022	0.955031362839887	ITPR2/TMEM37/KCNN4/CLIC3/TMEM150C	5
GO:0004620	phospholipase activity	1/439	104/18367	0.919790971773182	0.961599652308326	HMOX1	1
GO:0004252	serine-type endopeptidase activity	2/439	174/18367	0.922807146532478	0.963243140433745	CTSC/HTRA1	2
GO:0042626	ATPase-coupled transmembrane transporter activity	1/439	109/18367	0.928979672829003	0.968171002776477	ATP2B4	1
GO:0000149	SNARE binding	1/439	110/18367	0.930687303655384	0.968437490699128	TMED9	1
GO:0030594	neurotransmitter receptor activity	1/439	111/18367	0.932353967055466	0.968660585710273	ADRB1	1
GO:0099094	ligand-gated cation channel activity	1/439	113/18367	0.935568290759129	0.970488413586842	ITPR2	1
GO:0015267	channel activity	7/439	480/18367	0.943312703558333	0.974758219768687	LRRC8D/ITPR2/TMEM37/KCNN4/FXYD3/CLIC3/TMEM150C	7
GO:0008234	cysteine-type peptidase activity	2/439	190/18367	0.943849854235055	0.974758219768687	LGMN/CTSC	2
GO:0022803	passive transmembrane transporter activity	7/439	481/18367	0.94406868061555	0.974758219768687	LRRC8D/ITPR2/TMEM37/KCNN4/FXYD3/CLIC3/TMEM150C	7
GO:0005267	potassium channel activity	1/439	121/18367	0.946971972113955	0.976244676043289	KCNN4	1
GO:0005244	voltage-gated ion channel activity	2/439	201/18367	0.955021634830923	0.979866139703613	TMEM37/CLIC3	2
GO:0022832	voltage-gated channel activity	2/439	201/18367	0.955021634830923	0.979866139703613	TMEM37/CLIC3	2
GO:0140098	catalytic activity, acting on RNA	5/439	386/18367	0.955647445657494	0.979866139703613	EIF4A1/DDX39B/DDX3X/DHX36/POLR2L	5
GO:0004519	endonuclease activity	1/439	129/18367	0.956361104868144	0.979866139703613	N4BP2	1
GO:0004518	nuclease activity	2/439	210/18367	0.962550250987082	0.984694811976049	NME1/N4BP2	2
GO:0008168	methyltransferase activity	2/439	214/18367	0.965494042892231	0.985985365547971	DNMT1/METTL17	2
GO:0015276	ligand-gated ion channel activity	1/439	143/18367	0.968977431156128	0.985985365547971	ITPR2	1
GO:0022834	ligand-gated channel activity	1/439	143/18367	0.968977431156128	0.985985365547971	ITPR2	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	1/439	144/18367	0.969724737330538	0.985985365547971	AGL	1
GO:0016741	transferase activity, transferring one-carbon groups	2/439	225/18367	0.972487637086842	0.98728957981267	DNMT1/METTL17	2
GO:0015079	potassium ion transmembrane transporter activity	1/439	155/18367	0.97684947360857	0.988278102116386	KCNN4	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/439	156/18367	0.977407516716732	0.988278102116386	DNMT1	1
GO:0004175	endopeptidase activity	5/439	430/18367	0.977906367911267	0.988278102116386	ADAMTS6/MME/LGMN/CTSC/HTRA1	5
GO:0046943	carboxylic acid transmembrane transporter activity	1/439	163/18367	0.980955517884406	0.988827284985455	SLC27A2	1
GO:0005342	organic acid transmembrane transporter activity	1/439	164/18367	0.981414786597258	0.988827284985455	SLC27A2	1
GO:0005261	cation channel activity	3/439	335/18367	0.987638120307411	0.993596721334907	ITPR2/TMEM37/KCNN4	3
GO:0019787	ubiquitin-like protein transferase activity	3/439	458/18367	0.998950631130966	0.999704905942524	UBE2I/UBE2J1/TRIM24	3
GO:0061630	ubiquitin protein ligase activity	1/439	304/18367	0.999398698682622	0.999704905942524	TRIM24	1
GO:0061659	ubiquitin-like protein ligase activity	1/439	316/18367	0.999552464142607	0.999704905942524	TRIM24	1
GO:0004842	ubiquitin-protein transferase activity	2/439	433/18367	0.999704905942524	0.999704905942524	UBE2J1/TRIM24	2