category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	24/435	78/9376	6.63200707338638	TGFB1/NCF1/NCF2/FCGR3A/FCGR2A/NCF4/HLA-DQA2/ITGA4/EEF1A1/TNF/CYBB/HLA-DMA/FCGR1A/CYBA/IFNGR2/HLA-DMB/TLR2/IL1B/ITGB2/STAT1/HLA-DPA1/HLA-DRA/PTPN6/JAK1	11.0167359723917
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/435	116/9376	5.20269520412208	ACTG1/NCF1/EZR/NCF2/MYL9/CXCR4/ACTB/NCF4/MSN/ITGA4/RAC2/CYBB/RASSF5/VASP/CYBA/ICAM1/CTNNA1/CD99/VAV2/RHOA/CDC42/ITGB2/CTNNB1/RAP1B/RAP1A/BCAR1/PECAM1/GNAI3	10.0458945451447
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	34/435	180/9376	4.07131545338442	HLA-F/PILRA/OAS2/SOCS3/HLA-A/TAP1/BIRC3/HLA-DQA2/CFP/HLA-E/BST2/ITGA5/TNF/HLA-B/HLA-C/TNFRSF1A/HLA-DMA/IFNGR2/ALYREF/HLA-DMB/SRSF5/TLR2/TNFSF14/IL1B/OAS1/STAT1/EIF2AK2/HLA-DPA1/IRF7/HLA-DRA/SRSF1/CASP8/JAK1/IRF9	9.17695105489581
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/435	142/9376	4.55366682855755	TGFB1/NCF1/NCF2/FCGR3A/SOCS3/FCGR2A/LILRB4/NCF4/LILRB1/TNF/LILRB2/CSF1R/TNFRSF1A/FCGR1A/SPI1/CYBA/NFKB2/IFNGR2/LCP2/ATP2A3/IL1B/JUNB/STAT1/FOSL1/TYROBP/LILRB3/TGFBR1/LILRA5/JAK1/IRF9	9.41159357841959
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/435	155/9376	4.17174638487208	ACTG1/HLA-F/NCF1/NCF2/FCGR3A/HLA-A/TAP1/FCGR2A/CORO1A/ACTB/NCF4/HLA-DQA2/HLA-E/ITGA5/TFRC/CTSS/HLA-B/HLA-C/TUBB6/CYBB/HLA-DMA/FCGR1A/CYBA/HLA-DMB/TLR2/ITGB2/RAB7A/HLA-DPA1/ATP6V1B2/HLA-DRA	8.78238579202739
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	33/435	193/9376	3.68540289440772	NCF1/CCL3L3/LYN/CXCR4/PPBP/CCL3/GNG11/RAC2/STAT3/GNG2/FGR/CCR1/CXCR6/CCL4L2/CXCL10/PF4/HCK/VAV2/CXCL8/RHOA/CDC42/PLCB3/STAT1/WAS/ARRB2/PLCB2/GNGT2/PREX1/RAP1B/RAP1A/BCAR1/GNAI3/CRKL	8.31444058631566
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/435	216/9376	3.39276287782035	CYP2J2/TNFSF10/NCF1/CCL3L3/NCF2/LYN/NCF4/CCL3/NLRP3/SOD2/TNF/STAT3/TNFRSF1A/HSPA1B/CYBB/CYBA/ICAM1/VAV2/CXCL8/RHOA/TLR2/CDC42/IL1B/HSP90AB1/PLCB3/ABCG1/ERO1A/PLCB2/HSPA6/IRF7/RAP1B/CASP8/ATF4/RAP1A	7.84722346655358
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/435	173/9376	3.6131021194605	TNFSF10/MX1/ACTG1/OAS2/SOCS3/ACTB/NLRP3/HLA-DQA2/TNF/TNFRSF1A/HLA-DMA/MX2/CXCL10/ICAM1/IFNGR2/CXCL8/HLA-DMB/IL1B/OAS1/STAT1/EIF2AK2/HLA-DPA1/TLR7/TRIM25/IRF7/HLA-DRA/CASP8/JAK1/IRF9	7.65159442361498
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/435	70/9376	5.54246305418719	CAV1/ACTG1/HLA-F/HLA-A/ACTB/HLA-DQA2/HLA-E/RAC2/HLA-B/HLA-C/HLA-DMA/ICAM1/HLA-DMB/CD86/ITGB2/HLA-DPA1/HLA-DRA/CASP8	8.41387622373145
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/435	248/9376	3.04189840563589	GAPDH/TNFSF10/FLNA/ACTG1/MYL9/DYNLL1/PTPRC/BIRC3/ACTB/NLRP3/PKN1/TNF/TUBB6/TNFRSF1A/PFN1/CXCL8/RHOA/PIK3C2A/TLR2/CDC42/ARF1/CYTH1/IL1B/HSP90AB1/NCKAP1L/PIK3C2B/STX10/RAB7A/ARPC4/ACTR3/CTNNB1/ACTR2/CASP8/RAB9A/RIPK2	7.1880216079437
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	31/435	205/9376	3.25938884216428	HLA-F/ISG15/LYN/OAS2/HLA-A/TAP1/VIM/HLA-DQA2/HLA-E/TNF/HLA-B/HLA-C/STAT3/HLA-DMA/CXCL10/ICAM1/NFKB2/CD44/HLA-DMB/TLR2/OAS1/STAT1/EIF2AK2/HLA-DPA1/RUNX3/TNFAIP3/IRF7/HLA-DRA/CASP8/JAK1/IRF9	7.21434293499266
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/435	227/9376	3.03845257987746	HLA-F/CCL3L3/CXCR4/HLA-A/TAP1/VEGFA/CCL3/IL10RA/HLA-E/GNG11/RAC2/TNF/HLA-B/HLA-C/STAT3/TNFRSF1A/GNG2/CCR1/CCL4L2/CXCL8/RHOA/IL1B/PLCB3/PLCB2/GNGT2/CTNNB1/CASP8/ATF4/JAK1/BCAR1/GNAI3/CRKL	6.8574704847745
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/435	187/9376	3.22734034052492	TXNIP/GBP5/GBP4/OAS2/GBP2/BIRC3/NLRP3/PKN1/TNF/CYBB/CYBA/CXCL8/RHOA/PSTPIP1/IL1B/OAS1/HSP90AB1/PLCB3/STAT1/NAMPT/PLCB2/GBP1/TNFAIP3/IRF7/CASP8/RIPK2/JAK1/IRF9	6.78594725379909
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/435	95/9376	4.31080459770115	TGFB1/CCL3L3/VEGFA/CCL3/TNFSF13B/HLA-DQA2/TNF/HLA-DMA/ICAM1/CXCL8/HLA-DMB/TLR2/IL1B/CD86/ITGB2/HLA-DPA1/ATP6V1B2/HLA-DRA/FLT1	7.1537734935507
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/435	44/9376	6.36823406478579	HLA-F/HLA-A/HLA-DQA2/HLA-E/TNF/HLA-B/HLA-C/HLA-DMA/HLA-DMB/IL1B/CD86/HLA-DPA1/HLA-DRA	7.872408761665
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/435	181/9376	3.21524099828539	TGFB1/FCGR3A/CLEC4E/FCGR2A/CORO1A/IL10RA/HLA-DQA2/CTSS/TNF/TNFRSF1A/LSP1/HLA-DMA/FCGR1A/IFNGR2/HLA-DMB/RHOA/TLR2/PLK3/IL1B/ITGB2/STAT1/RAB7A/HLA-DPA1/HLA-DRA/CASP8/RIPK2/JAK1	6.63776114136422
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/435	45/9376	6.22671775223499	HLA-F/HLA-A/HLA-DQA2/HLA-E/TNF/HLA-B/HLA-C/HLA-DMA/HLA-DMB/IL1B/CD86/HLA-DPA1/HLA-DRA	7.75190478669598
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/435	138/9376	3.59233716475096	ACTG1/FCGR2A/ACTB/NLRP3/PKN1/ITGA4/RAC2/ITGA5/TNF/WIPF1/VAV2/CXCL8/LCP2/RHOA/CDC42/IL1B/RPS6KA1/WAS/ARPC4/ACTR3/ACTR2/BCAR1/CRKL	6.76673656888407
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/435	98/9376	4.17884119164907	NCF1/FCGR3A/PTPRC/LYN/FCGR2A/MARCKS/RAC2/MYO10/FCGR1A/VASP/HCK/VAV2/CDC42/CFL1/WAS/ARPC4/ACTR3/ACTR2/CRKL	6.97737243213154
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/435	39/9376	6.63200707338638	HLA-F/HLA-A/HLA-DQA2/HLA-E/TNF/HLA-B/HLA-C/HLA-DMA/HLA-DMB/CD86/HLA-DPA1/HLA-DRA	7.77372252579559
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/435	99/9376	4.13663067456171	KRT19/FCGR3A/FCGR2A/HLA-DQA2/KRT18/SELPLG/KRT23/HLA-DMA/FCGR1A/ICAM1/PTAFR/C5AR1/HLA-DMB/FPR3/ITGB2/FPR1/HLA-DPA1/HLA-DRA/FPR2	6.92013271604606
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	28/435	200/9376	3.0175632183908	GAPDH/TNFSF10/ACTG1/EZR/MYO1G/FCGR2A/ACTB/NLRP3/TNF/MYH9/TUBB6/MYO10/TNFRSF1A/WIPF1/CXCL8/RHOA/TMBIM6/CDC42/ARF1/CYTH1/IL1B/NCKAP1L/ARPC4/ACTR3/ACTR2/PTPN6/CASP8/NCL	6.36139944170066
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/435	82/9376	4.46851696103168	HLA-F/HLA-A/TAP1/HLA-DQA2/HLA-E/CTSS/TNF/HLA-B/HLA-C/HSPA1B/HLA-DMA/IFI30/HLA-DMB/HSP90AB1/HLA-DPA1/HSPA6/HLA-DRA	6.95803539909867
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/435	112/9376	3.84893267651888	TGFB1/BIRC3/IL10RA/HLA-DQA2/TNF/STAT3/TNFRSF1A/HSPA1B/HLA-DMA/IFNGR2/HLA-DMB/TLR2/STAT1/HLA-DPA1/LAMC2/HSPA6/HLA-DRA/CASP8/JAK1/GNAI3	6.69004661519982
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/435	160/9376	3.23310344827586	HLA-F/VCAN/PTPRC/HLA-A/HLA-DQA2/HLA-E/ITGA4/HLA-B/HLA-C/SELPLG/HLA-DMA/ICAM1/CD99/SIGLEC1/HLA-DMB/ICAM3/CD86/ITGB2/TIGIT/HLA-DPA1/HLA-DRA/SELL/CADM1/PECAM1	6.28398036991217
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/435	204/9376	2.852738336714	FLNA/CAV1/TGFB1/ACTG1/IGF2/EZR/TIMP3/PPP1R12C/VEGFA/PLAUR/ACTB/MSN/CD63/ITGA5/TNF/STAT3/DCN/CD44/EIF4B/VAV2/RHOA/TLR2/CDC42/HPSE/CAV2/CTNNB1/PTPN6	5.90111893681177
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/435	196/9376	2.85920713112831	HLA-F/LYN/HLA-A/VEGFA/HLA-E/ZFP36/GNG11/HLA-B/HLA-C/STAT3/TNFRSF1A/GNG2/CCR1/ICAM1/HCK/CXCL8/CD86/STAT1/EIF2AK2/GNGT2/PREX1/IRF7/CTNNB1/CASP8/JAK1/IRF9	5.80191939315657
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/435	142/9376	3.18756677999029	CAV1/ACTG1/NCF1/NCF2/VEGFA/KLF2/ACTB/RAC2/TNF/HMOX1/TNFRSF1A/CYBA/ICAM1/RHOA/IL1B/HSP90AB1/CAV2/SUMO3/CTNNB1/PIAS4/PECAM1	5.79359024134448
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/435	203/9376	2.76061378177906	FLNA/CAV1/ACTG1/FLNB/MYL9/PPP1R12C/VEGFA/BIRC3/ACTB/PGF/ITGA4/RAC2/ITGA5/VASP/PARVG/VAV2/RHOA/CDC42/CAV2/LAMC2/CTNNB1/RAP1B/FLT1/RAP1A/BCAR1/CRKL	5.59362874684142
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/435	78/9376	4.14500442086649	CAV1/ACTG1/ACTB/ITGA5/CTNNA1/RHOA/CDC42/ARPC4/CAV2/ACTR3/CTNNB1/ACTR2/BCAR1/CLTB/CRKL	6.15192468425966
NA	NA	hsa04517	IgSF CAM signaling	33/435	299/9376	2.37887210241033	ACTG1/EZR/MYL9/DYNLL1/LYN/ACTB/DOK2/MSN/ITGA4/ITGA5/CD48/MYH9/TUBB6/ICAM1/VAV2/LCP2/RHOA/CDC42/CSK/ICAM3/CD86/ITGB2/CD84/TIGIT/ARPC4/ACTR3/CTNNB1/ACTR2/PTPN6/RAP1B/CADM1/RAP1A/BCAR1	5.34472827480628
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	26/435	212/9376	2.64341791368467	ACTG1/VEGFA/ACTB/PGF/RAC2/CSF1R/RASSF5/PFN1/VASP/VAV2/LCP2/RHOA/CDC42/APBB1IP/PLCB3/ITGB2/FPR1/RALB/PLCB2/CTNNB1/RAP1B/FLT1/RAP1A/BCAR1/GNAI3/CRKL	5.33839402832865
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/435	100/9376	3.44864367816092	TNFSF10/TNFRSF1B/CCL3L3/CXCR4/PPBP/CCL3/IL10RA/TNF/CSF1R/TNFRSF1A/CCR1/CCL4L2/CXCL10/PF4/CXCL8/TNFSF14	5.42978259784385
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/435	136/9376	3.01122379986477	MX1/OAS2/MSN/STAT3/HSPA1B/MX2/TLR2/IL1B/OAS1/STAT1/EIF2AK2/TLR7/TNFAIP3/HSPA6/IRF7/CASP8/RAB9A/JAK1/IRF9	5.2111201600979
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	26/435	232/9376	2.41553705905668	TMSB4X/ACTG1/EZR/MYL9/CXCR4/PPP1R12C/ACTB/MSN/ITGA4/RAC2/ITGA5/MYH9/PFN1/VAV2/RHOA/CDC42/CFL1/ITGB2/NCKAP1L/ARPC4/PIP4K2A/ACTR3/ACTR2/ARHGEF6/BCAR1/CRKL	4.81542193557511
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/435	54/9376	4.39063431247339	HLA-F/HLA-A/HLA-DQA2/HLA-E/HLA-B/HLA-C/HLA-DMA/HLA-DMB/CD86/HLA-DPA1/HLA-DRA	5.51138186062951
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	27/435	250/9376	2.32783448275862	CAV1/HLA-F/CXCR4/HLA-A/HLA-E/TFRC/HLA-B/HLA-C/WIPF1/HSPA1B/ACAP1/RHOA/CDC42/ARF1/CYTH1/ARAP1/ARRB2/RAB7A/TGFBR1/ARPC4/CAV2/HSPA6/ACTR3/ACTR2/CAPZB/ARF4/CLTB	4.69365251211902
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/435	109/9376	3.16389328271644	TGFB1/EBI3/HLA-DQA2/STAT3/HLA-DMA/IFNGR2/HLA-DMB/RUNX1/IL1B/HSP90AB1/STAT1/RARA/TGFBR1/HLA-DPA1/HLA-DRA/JAK1	5.01206535603186
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/435	56/9376	4.23382594417077	EEF1A1/TNF/HSPA1B/NFKB2/CXCL8/TLR2/ARF1/IL1B/ITGB2/HSPA6/CASP8	5.35352601599264
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/435	66/9376	3.91891327063741	TGFB1/HLA-DQA2/TNF/STAT3/HLA-DMA/IFNGR2/HLA-DMB/TLR2/IL1B/STAT1/HLA-DPA1/HLA-DRA	5.24874576885886
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/435	110/9376	3.13513061650993	LDHA/ALDOA/GAPDH/VEGFA/PFKFB3/ENO1/TFRC/TIMP1/HMOX1/STAT3/CYBB/PFKP/IFNGR2/PGK1/HK1/FLT1	4.96834633321509
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/435	67/9376	3.86042202779207	LDHA/ALDOA/GAPDH/PKM/TPI1/ENO1/PFKP/PGK1/HK1/ADPGK/ALDH2/PGM2	5.18266597489451
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/435	100/9376	3.23310344827586	CD9/HLA-DQA2/ITGA4/ITGA5/TFRC/TNF/CSF1R/HLA-DMA/FCGR1A/CD44/CD1D/HLA-DMB/IL1B/HLA-DPA1/HLA-DRA	4.95182959888235
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/435	233/9376	2.31266341078388	PDLIM2/ACTG1/DSP/MYL9/VCAN/SYNE1/ENO1/ACTB/VIM/TPM4/ITGA4/ITGA5/MYH9/DCN/PDLIM4/PLEC/TMEM43/TNNI2/TPM3/SUN2/LMNA/MYL4/NEBL/CAPZB/PDLIM5	4.47532108721036
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/435	50/9376	4.31080459770115	TGFB1/CXCR4/TNFSF13B/HLA-DQA2/ITGA4/HLA-DMA/HLA-DMB/CD86/HLA-DPA1/HLA-DRA	5.17735644060379
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/435	50/9376	4.31080459770115	TGFB1/TNF/ICAM1/CXCL8/GYPC/TLR2/IL1B/ITGB2/CD81/PECAM1	5.17735644060379
NA	NA	hsa04518	Integrin signaling	19/435	154/9376	2.65926257650396	FLNA/TGFB1/ACTG1/FLNB/VEGFA/ACTB/PGF/ITGA4/RAC2/ITGA5/ICAM1/PARVG/CDC42/ICAM3/ITGB2/LAMC2/CTNNB1/ARHGEF6/FLT1	4.5793109951379
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/435	105/9376	3.07914614121511	LYN/BIRC3/TNFSF13B/BCL2A1/TNF/TNFRSF1A/CCL4L2/ICAM1/NFKB2/CXCL8/TNFSF14/IL1B/TNFAIP3/TRIM25/PIAS4	4.7255634063263
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	20/435	168/9376	2.56595511767926	TNFSF10/PYGL/BIRC3/NLRP3/FTL/TNF/STAT3/TNFRSF1A/CYBB/PGAM5/FTH1/IFNGR2/IL1B/HSP90AB1/STAT1/EIF2AK2/TNFAIP3/CASP8/JAK1/IRF9	4.51739966420752
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/435	195/9376	2.43173592690834	ACTG1/NCF1/NCF2/FCGR3A/FCGR2A/ACTB/NCF4/RAC2/SELPLG/CYBB/FCGR1A/CYBA/C5AR1/FPR3/TLR2/AQP9/PLCB3/ITGB2/FPR1/PLCB2/TLR7/FPR2	4.45627982834379
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/435	253/9376	2.21503793557767	ACTG1/MYL9/ACTB/NLRP3/ITGA5/TNF/TNFRSF1A/PFN1/CD44/CXCL8/RHOA/CDC42/ARF1/CYTH1/IL1B/HK1/PLCB3/PLCB2/ARPC4/ACTR3/ACTR2/UBE2V2/UBE2D1/RIPK2/BCAR1/CRKL	4.32134042109752
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/435	109/9376	2.96614995254666	CCL3L3/CCL3/TNF/CCL4L2/CXCL10/CXCL8/TLR2/IL1B/CD86/STAT1/TLR7/IRF7/CASP8/JAK1/IRF9	4.55404716149034
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/435	101/9376	2.98768635484238	TGFB1/VEGFA/TNF/STAT3/CYBB/ICAM1/CXCL8/CDC42/IL1B/PLCB3/STAT1/PIM1/PLCB2/TGFBR1	4.42984778256696
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/435	103/9376	2.92967302756389	TGFB1/CCL3L3/CCL3/TNF/TNFRSF1A/IFNGR2/CXCL8/TLR2/IL1B/PLCB3/PLCB2/TGFBR1/CASP8/GNAI3	4.34339601084951
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/435	103/9376	2.92967302756389	SERPINB9/TGFB1/PRDX1/TNF/CD1D/CXCL8/TLR2/IL1B/PLCB3/ITGB2/PLCB2/RAB7A/ARG2/LAMC2	4.34339601084951
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/435	224/9376	2.21313628899836	TGFB1/HLA-F/TSPO/HLA-A/HLA-DQA2/HLA-E/ZFP36/TNF/HLA-B/HLA-C/TNFRSF1A/HLA-DMA/SPI1/ICAM1/NFKB2/HLA-DMB/ITGB2/FOSL1/TGFBR1/HLA-DPA1/HLA-DRA/ATF4/JAK1	4.05333796815645
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/435	170/9376	2.40897903989182	ACTG1/EZR/MYL9/ACTB/MSN/YBX3/MYH9/RAB8B/VASP/CD1D/RHOA/CDC42/RUNX1/WAS/ARPC4/CRB3/ACTR3/ACTR2/RAP1A	4.08912820639243
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/435	93/9376	3.01292794462984	ACTG1/MYL9/ACTB/RAC2/CTNNA1/RHOA/CDC42/WAS/TGFBR1/CTNNB1/PTPN6/RAP1B/RAP1A	4.30291480409285
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/435	214/9376	2.21583413900526	TNFRSF1B/HLA-F/CXCR4/HLA-A/TAP1/APOBEC3A/HLA-E/GNG11/BST2/RAC2/TNF/HLA-B/HLA-C/TNFRSF1A/GNG2/TLR2/AP1S2/CFL1/GNGT2/CASP8/GNAI3/CRKL	3.96847177506175
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/435	133/9376	2.59296517154956	TNFSF10/FCGR3A/HLA-A/HLA-E/RAC2/CD48/TNF/HLA-B/HLA-C/ICAM1/IFNGR2/VAV2/LCP2/ITGB2/TYROBP/PTPN6	4.08096475217024
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/435	298/9376	1.95288127748206	TNFSF10/TGFB1/TNFRSF1B/CCL3L3/CXCR4/EBI3/GH2/PPBP/CCL3/IL10RA/TNFSF13B/TNF/CSF1R/TNFRSF1A/CCR1/CXCR6/CCL4L2/CXCL10/PF4/IFNGR2/CXCL8/TNFSF14/IL1B/LEP/TGFBR1/RELT/IL1RN	3.68713514331088
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	23/435	238/9376	2.08295180141022	MX1/ISG15/OAS2/FCGR2A/NLRP3/TNF/STAT3/TNFRSF1A/CYBB/MX2/CXCL10/C5AR1/CXCL8/TLR2/RPL4/IL1B/OAS1/STAT1/EIF2AK2/TLR7/F13A1/JAK1/IRF9	3.73258106804703
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/435	300/9376	1.93986206896552	FLNA/TGFB1/IGF2/VEGFA/PGF/RAC2/TNF/CSF1R/TNFRSF1A/HSPA1B/NFKB2/CDC42/IL1B/RPS6KA1/ARRB2/STK3/EREG/DUSP5/TGFBR1/HSPA6/DUSP9/RAP1B/FLT1/ATF4/RAP1A/MAPKAPK3/CRKL	3.64934334651958
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/435	156/9376	2.34883583849101	MX1/OAS2/SOCS3/TNF/STAT3/TNFRSF1A/MX2/CXCL10/OAS1/STAT1/CD81/EIF2AK2/IRF7/CTNNB1/CASP8/JAK1/IRF9	3.74708163188867
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/435	91/9376	2.84228874573702	DAPP1/LYN/LILRB4/LILRB1/RAC2/LILRB2/PIK3AP1/VAV2/CD81/LILRB3/LILRA5/PTPN6	3.89515424828588
Organismal Systems	Immune system	hsa04611	Platelet activation	14/435	126/9376	2.39489144316731	ACTG1/LYN/FCGR2A/ACTB/VASP/LCP2/RHOA/APBB1IP/PLCB3/SNAP23/PLCB2/RAP1B/RAP1A/GNAI3	3.47689868350427
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/435	77/9376	2.79922376474101	TGFB1/VEGFA/RAC2/STAT3/CDC42/STAT1/RALB/TGFBR1/ARHGEF6/JAK1	3.49662965682678
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/435	78/9376	2.76333628057766	NLRP3/ITGA5/TNF/IRF8/CXCL8/RHOA/IL1B/CFL1/ITGB2/GNAI3	3.44925174640854
Human Diseases	Immune disease	hsa05310	Asthma	6/435	32/9376	4.04137931034483	HLA-DQA2/TNF/HLA-DMA/HLA-DMB/HLA-DPA1/HLA-DRA	3.80116201530411
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	27/435	333/9376	1.74762348555452	PKM/MX1/HLA-F/ISG15/HLA-A/VEGFA/HLA-E/ITGA4/ITGA5/TNF/HLA-B/HLA-C/TNFRSF1A/MX2/LFNG/CDC42/NOTCH1/STAT1/EIF2AK2/CRB3/LAMC2/ATP6V1B2/OASL/CTNNB1/CASP8/JAK1/IRF9	3.06398056524102
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/435	119/9376	2.35464116681155	TNFRSF1B/SOCS3/BIRC3/TNF/TNFRSF1A/PGAM5/CXCL10/ICAM1/IL1B/JUNB/TNFAIP3/CASP8/ATF4	3.28019632352187
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/435	68/9376	2.852738336714	BCL2A1/CSF1R/STAT3/FCGR1A/SPI1/RUNX1/PIM1/RARA/PER2	3.38203093937005
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/435	122/9376	2.29674015451291	IGFBP3/SOCS3/GH2/STAT3/IRS1/JUNB/PLCB3/STAT1/PLCB2/ATF4/BCAR1/GNAI3/CRKL	3.17984057223179
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/435	205/9376	1.89254835996636	PKM/HLA-F/LYN/HLA-A/HLA-E/HLA-B/HLA-C/STAT3/NFKB2/RHOA/CDC42/EIF2AK2/IRF7/CASP8/HNRNPK/ATF4/JAK1/IRF9	2.8499520908913
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/435	75/9376	2.58648275862069	ALDOA/GAPDH/PKM/TPI1/ENO1/PFKP/PGK1/ARG2/PRPS2	3.04255463401906
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/435	105/9376	2.25804050355775	CLEC4E/NLRP3/TNF/LSP1/NFKB2/RHOA/PLK3/IL1B/STAT1/CASP8/IRF9	2.85932289676108
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	12/435	120/9376	2.15540229885057	ARHGDIB/RHOA/CDC42/IRS1/SH2B2/RPS6KA1/RAP1B/ATF4/RIPK2/RAP1A/CRKL/IRAK3	2.80963171525961
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/435	93/9376	2.31763688048449	HLA-DQA2/HLA-DMA/IFNGR2/HLA-DMB/NOTCH1/STAT1/HLA-DPA1/RUNX3/HLA-DRA/JAK1	2.81663298211007
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/435	201/9376	1.82297706867959	LMO2/IGFBP3/BIRC3/LYL1/BCL2A1/ETV4/CSF1R/MLLT1/FCGR1A/SPI1/CXCL8/RUNX1/CD86/RARA/PER2/SS18/FLT1	2.60147673134086
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/435	42/9376	3.07914614121511	TFRC/FTL/HMOX1/CYBB/FTH1/PCBP1	2.97860546994565
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/435	99/9376	2.177174039243	TGFB1/ACTG1/ACTB/TPM4/ITGA4/ITGA5/TNF/ATP2A3/TPM3/LMNA	2.59711819039195
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/435	86/9376	2.25565356856456	ACTG1/DSP/ACTB/ITGA4/ITGA5/CTNNA1/ATP2A3/LMNA/CTNNB1	2.5801706047324
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/435	35/9376	3.07914614121511	ALDOA/TPI1/PFKFB3/PFKP/HK1	2.71806333306093
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/435	105/9376	2.0527640941434	TGFB1/ACTG1/ACTB/TPM4/ITGA4/ITGA5/TNF/ATP2A3/TPM3/LMNA	2.39276276936977
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/435	36/9376	2.99361430395913	PYGL/UGP2/GBE1/HK1/PGM2	2.64335913968449
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/435	37/9376	2.91270580925753	TNF/ICAM1/IL1B/PLCB3/PLCB2	2.57120124953802
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/435	94/9376	2.06368305209098	TNF/CXCL10/CXCL8/IL1B/HSP90AB1/FOSL1/TNFAIP3/SRSF1/CASP8	2.28608620812121
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/435	157/9376	1.78472801815653	TGFB1/RAB17/HAVCR2/ATP11A/ATP2A3/NR1H2/DUSP5/RAB7A/ARG2/PTPN6/BCAR1/PECAM1/CRKL	2.18707812596635
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/435	157/9376	1.78472801815653	TGFB1/SOCS3/TNF/TNFRSF1A/CXCL8/COX7B2/CDC42/IRS1/IL1B/LEP/CASP8/ATF4/COX8C	2.18707812596635
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/435	130/9376	1.82380194518126	TGFB1/VEGFA/GNG11/GNG2/PLCB3/ARRB2/PLCB2/GNGT2/TGFBR1/ATF4/GNAI3	2.08619434543974
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/435	116/9376	1.8581054300436	ALDOA/GAPDH/PKM/TPI1/ENO1/PFKP/PGK1/HK1/ADPGK/PRPS2	2.05116865253017
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/435	70/9376	2.15540229885057	TNFRSF1B/SOCS3/TNF/STAT3/TNFRSF1A/IRS1/LEP	2.14011909732153
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/435	71/9376	2.12504451999352	LDHA/PKM/SLC16A3/SLC7A5/PFKP/HK1/GLS	2.09883314230545
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/435	30/9376	2.87386973180077	TNF/ABCC3/IL1B/ATIC	2.26738022416087
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/435	72/9376	2.09553001277139	ISG15/TNF/CXCL10/CXCL8/TRIM25/IRF7/CASP8	2.05822522478875
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/435	73/9376	2.06682412218548	MX1/CXCR4/APOBEC3A/BST2/MLLT1/MX2/NELFB	2.01827325801394
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/435	137/9376	1.73061498447856	TNFSF10/ACTG1/BIRC3/ACTB/BCL2A1/CTSS/TNF/TNFRSF1A/LMNA/CASP8/ATF4	1.90008747135692
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/435	31/9376	2.78116425658139	ALDOA/PFKP/PGM2/PRPS2	2.19094958676671
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	15/435	205/9376	1.5771236333053	GAPDH/TGFB1/NCF1/NCF2/NCF4/RAC2/CYBB/CYBA/COX7B2/IRS1/ATP2A3/PLCB3/PLCB2/TGFBR1/COX8C	1.84278497302176
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/435	139/9376	1.70571404945009	KRT19/KRT18/KRT23/HSPA1B/HSP90AB1/PLCB3/RARA/PLCB2/HSPA6/ATF4/GNAI3	1.84887653680917
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/435	75/9376	2.01170881226054	GPX3/ASGR1/GPX1/ASGR2/PLCB3/PLCB2/ATF4	1.94025388444652
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/435	32/9376	2.69425287356322	UGP2/PFKP/HK1/PGM2	2.11750295183608
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/435	76/9376	1.98523895946763	ACTG1/EZR/ACTB/PLCB3/PLCB2/HRH2/GNAI3	1.90214718104167
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/435	47/9376	2.29298116898997	PKM/SOCS3/TNF/IRS1/HK1	1.96002134765014
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/435	143/9376	1.6580017683466	FCGR3A/FCGR2A/HLA-DQA2/SSB/TNF/HLA-DMA/FCGR1A/HLA-DMB/CD86/HLA-DPA1/HLA-DRA	1.74888350228966
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/435	110/9376	1.76351097178683	TGFB1/TFRC/TNF/SKIL/DCN/EMP3/GREM2/RHOA/TGFBR1	1.77665333807411
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/435	51/9376	2.11313950867703	ACTG1/ACTB/ARF1/ERO1A/ATP6V1B2	1.75811583070208
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/435	238/9376	1.44900994880711	IGF2/VEGFA/PGF/GNG11/RAC2/CSF1R/RGL2/GNG2/RASSF5/RHOA/CDC42/RALB/GNGT2/RAP1B/FLT1/RAP1A	1.54759060569431
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/435	275/9376	1.41080877742947	CAV1/NCF1/NCF2/NCF4/RAC2/TNF/TUBB6/HSPA1B/CYBB/CYBA/COX7B2/STIP1/IL1B/NOTCH1/CAV2/HSPA6/ATF4/COX8C	1.52510141220983
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/435	67/9376	1.93021101389604	RPS6KA1/PLCB3/PLCB2/RAP1B/ATF4/RAP1A	1.68540618284651
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/435	133/9376	1.62060323221848	TNFSF10/TGFB1/KLF2/SOD2/HOMER3/STAT3/IRS1/PLK3/TGFBR1/CSNK1E	1.58990288111753
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/435	83/9376	1.8178091677053	NLRP3/CCL4L2/CXCL10/IL1B/IRF7/CASP8/PCBP1	1.65063204279697
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/435	37/9376	2.33016464740603	UGP2/HK1/UAP1L1/PGM2	1.78810614102191
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/435	168/9376	1.53957307060755	SOCS3/GH2/IL10RA/STAT3/IFNGR2/STAT1/PIM1/LEP/PTPN6/JAK1/PIAS4/IRF9	1.55653708108206
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/435	52/9376	2.07250221043325	CYP2J2/CYP11A1/CYP1B1/CYP19A1/HSD3B1	1.71055071400009
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/435	38/9376	2.26884452510587	UGP2/HK1/UAP1L1/PGM2	1.72866362218424
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/435	70/9376	1.84748768472906	TGFB1/VEGFA/CDC42/RAP1B/RAP1A/CRKL	1.56977754037518
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/435	87/9376	1.73423173470736	TGFB1/RAC2/RHOA/RALB/EREG/TGFBR1/CTNNB1	1.51755875865121
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/435	157/9376	1.51015447690168	TGFB1/HLA-F/IGFBP3/HLA-A/HLA-E/HLA-B/HLA-C/RASSF5/CXCL8/ZFP36L2/TGFBR1	1.42182727197196
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/435	157/9376	1.51015447690168	TGFB1/ACTG1/BIRC3/ACTB/CTNNA1/ITGB2/STK3/TGFBR1/CSNK1E/CTNNB1/WTIP	1.42182727197196
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/435	122/9376	1.59005087620124	ACTG1/ACTB/PFKP/ATP2A3/NOTCH1/PLCB3/STAT1/PLCB2/CTNNB1	1.446911094174
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/435	194/9376	1.44434174665245	ACTG1/MYO1G/MYL9/DYNLL1/ACTB/TPM4/MYH9/TUBB6/MYO10/TNNI2/TPM3/MYL4/CAPZB	1.37938836309811
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	22/435	362/9376	1.30991299930145	IGF2/GH2/VEGFA/PGF/PKN1/GNG11/ITGA4/ITGA5/CSF1R/PIK3AP1/GNG2/EIF4B/TLR2/IRS1/HSP90AB1/EREG/GNGT2/LAMC2/DDIT4/FLT1/ATF4/JAK1	1.32639391472715
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/435	107/9376	1.61151573745837	LDHA/PKM/PYGL/PFKP/PLCB3/PLCB2/PPP4C/ATF4	1.40320235582666
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/435	90/9376	1.67642401021711	BATF3/STAT3/IFNGR2/TLR2/STAT1/PTPN6/JAK1	1.42220810440798
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/435	109/9376	1.58194664135822	PYGL/SOCS3/TNF/STAT3/TNFRSF1A/IRS1/NR1H2/RPS6KA1	1.34791979969968
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/435	163/9376	1.45456596854947	TGFB1/TNF/STAT3/CXCL8/TLR2/STAT1/TGFBR1/IRF7/CASP8/ATF4/JAK1	1.29130075412023
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/435	166/9376	1.42827863176845	MYL9/VASP/RHOA/IRS1/ATP2A3/PLCB3/KCNMB1/ADRA2C/PLCB2/ATF4/GNAI3	1.22797027663788
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/435	29/9376	2.22972651605232	STK3/CSNK1E/WTIP	1.46287977113702
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/435	78/9376	1.6580017683466	TPI1/PIK3C2A/PLCB3/PIK3C2B/PLCB2/PIP4K2A	1.28711339612765
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/435	97/9376	1.5554449579334	GNG11/GNG2/PLCB3/PLCB2/GNGT2/PER2/GNAI3	1.21286797185556
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/435	46/9376	1.87426286856572	BLVRA/FTL/HMOX1/FTH1	1.31104423983876
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/435	115/9376	1.49941029485257	NR4A2/OXSR1/RHOA/PLCB3/ARRB2/PLCB2/ATF4/GNAI3	1.18854242363225
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/435	98/9376	1.53957307060755	CYP11A1/NR4A2/CAMK1/PLCB3/PLCB2/HSD3B1/ATF4	1.18433166081652
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/435	116/9376	1.48648434403488	GNG11/HOMER3/GNG2/PLCB3/PLCB2/GNGT2/GLS/GNAI3	1.16286577557299
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/435	323/9376	1.26788370520622	EZR/TIMP3/VEGFA/MARCKS/VIM/ITGA5/HMOX1/STAT3/ZEB2/CD44/RHOA/IRS1/NOTCH1/PIM1/CYP1B1/DDIT4/HNRNPK/GLS/CRKL	1.08065860857373
NA	NA	hsa04519	Cadherin signaling	23/435	404/9376	1.22708546716741	KRT19/KRT8/ACTG1/DSP/MYO1G/ACTB/VIM/KRT18/RAC2/PKP3/KRT23/VASP/CTNNA1/VAV2/RHOA/CDC42/NCKAP1L/STK3/ARPC4/ACTR3/CTNNB1/ACTR2/WTIP	1.02913562176058
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/435	65/9376	1.6580017683466	CYP11A1/PLCB3/PLCB2/HSD3B1/ATF4	1.17414787107807
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/435	32/9376	2.02068965517241	BIRC3/TNFRSF1A/CASP8	1.27567342010206
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/435	17/9376	2.53576741041244	TFRC/MYH9	1.39788808686357
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/435	250/9376	1.29324137931034	CD63/CTSS/SLC11A1/LITAF/AP3S1/AP1S2/CD68/KXD1/RAB7A/TLR7/ATP6V1B2/VPS13C/LAPTM5/PSAP/CLTB	1.03655474724364
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/435	33/9376	1.9594566353187	VAMP5/STX3/SNAP23	1.21780110954123
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/435	50/9376	1.72432183908046	P4HA1/CNDP2/ARG2/ALDH2	1.13267703604044
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/435	140/9376	1.3856157635468	KLF2/GNG11/GNG2/PLCB3/PLCB2/MYL4/GNGT2/TGFBR1/GNAI3	1.01394419703982
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/435	34/9376	1.90182555780933	BHLHE40/CSNK1E/PER2	1.16192818182398
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/435	69/9376	1.56188572380476	LYN/RAC2/TNF/VAV2/LCP2	1.03324879027354
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/435	87/9376	1.48648434403488	TPM4/COX7B2/ATP2A3/TPM3/MYL4/COX8C	1.0054980496465
NA	NA	hsa04081	Hormone signaling	13/435	219/9376	1.27946255182911	IGF2/GH2/GNG11/STAT3/GNG2/RHOA/IRS1/PLCB3/ADRA2C/PLCB2/GNGT2/LEP/GNAI3	0.923009752786905
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/435	88/9376	1.46959247648903	SERPINA1/PLAUR/C5AR1/ITGB2/CLU/F13A1	0.976199503088548
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/435	144/9376	1.34712643678161	SCD/TNF/TNFRSF1A/C5AR1/CXCL8/IL1B/ALDH2/CTNNB1/CASP8	0.925887578453753
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/435	71/9376	1.51788894285252	LYN/CXCL8/CDC42/CSK/ATP6V1B2	0.966150634908789
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/435	20/9376	2.15540229885057	UGP2/UAP1L1	1.14088097442076
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/435	37/9376	1.74762348555452	TFG/TPM3/CTNNB1	1.0050110325058
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/435	170/9376	1.26788370520622	TGFB1/ACTG1/IGF2/ACTB/HMOX1/SMARCD3/TGFBR1/FRAT2/CTNNB1/FRAT1	0.777450042887633
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/435	22/9376	1.9594566353187	CNDP2/ALDH2	0.993745620064471
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/435	133/9376	1.29648258577478	GNG11/GNG2/PLCB3/ARRB2/PLCB2/GNGT2/ATF4/GNAI3	0.759548924099956
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/435	115/9376	1.311984007996	GNG11/GNG2/PLCB3/PLCB2/GNGT2/ATF4/GNAI3	0.742488156171336
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/435	115/9376	1.311984007996	CYP2J2/GNG11/GNG2/PLCB3/PLCB2/GNGT2/GNAI3	0.742488156171336
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/435	154/9376	1.25965069413345	ACTG1/MYL9/PPP1R12C/ACTB/CAMK1/RHOA/PLCB3/PLCB2/GNAI3	0.716596212906676
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/435	23/9376	1.87426286856572	ARG2/GLS	0.925907716735939
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/435	155/9376	1.25152391546162	CYP11A1/PLCB3/PLCB2/HSD3B1/CTNNB1/RAP1B/ATF4/RAP1A/GNAI3	0.696455451810772
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/435	117/9376	1.28955693093624	ACTG1/MBD3/MORF4L2/ACTB/MTA1/SMARCD3/SS18	0.695155675550493
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/435	60/9376	1.43693486590038	VEGFA/RAC2/CDC42/MAPKAPK3	0.748884437760214
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/435	60/9376	1.43693486590038	LYN/PLCB3/PLCB2/GNAI3	0.748884437760214
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/435	158/9376	1.22776080314273	SLC7A5/TNF/TNFRSF1A/EIF4B/RHOA/IRS1/RPS6KA1/ATP6V1B2/DDIT4	0.636834226481036
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/435	178/9376	1.21090016789358	RAC2/RHOA/PLCB3/FOSL1/PLCB2/FRAT2/CSNK1E/CTNNB1/TLE3/FRAT1	0.62658131991626
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/435	61/9376	1.41337855662333	FTL/HMOX1/FTH1/SLC26A6	0.714428303469816
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/435	62/9376	1.39058212829069	SOD2/HSPA1B/IRS1/HSPA6	0.680577073131212
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/435	62/9376	1.39058212829069	DTX3L/LFNG/NOTCH1/TLE3	0.680577073131212
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/435	102/9376	1.26788370520622	RHOA/ATP2A3/PLCB3/PLCB2/RAP1B/RAP1A	0.599998350651505
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/435	122/9376	1.23670623704541	PTPRC/TNF/VAV2/LCP2/RHOA/CDC42/PTPN6	0.580446355145104
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/435	45/9376	1.43693486590038	TAP1/ABCC3/ABCG1	0.648031448990947
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/435	144/9376	1.19744572158365	SKIL/STAT3/PCGF3/DUSP9/CTNNB1/KLF4/DLX5/JAK1	0.526645399665012
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/435	125/9376	1.20702528735632	RAC2/TNF/TNFRSF1A/RHOA/PLCB3/PLCB2/GNAI3	0.513950486376044
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/435	66/9376	1.3063044235458	CYP11A1/CYP1B1/CYP19A1/HSD3B1	0.550791989348045
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/435	47/9376	1.37578870139398	LDHA/PKM/ALDH2	0.569655532967505
NA	NA	hsa03272	Virion - Hepatitis viruses	3/435	48/9376	1.34712643678161	CD9/CD63/CD81	0.531803583628408
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/435	48/9376	1.34712643678161	HK1/PLCB3/PLCB2	0.531803583628408
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/435	149/9376	1.15726297924863	AGPAT2/CXCL8/RHOA/ARF1/CYTH1/PLCB3/RALB/PLCB2	0.426802143594832
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/435	89/9376	1.21090016789358	GNG11/GNG2/GNGT2/GLS/GNAI3	0.440931804047084
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/435	49/9376	1.31963406052076	LFNG/GALNT7/COLGALT1	0.494785908952769
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/435	91/9376	1.18428697739043	GNG11/GNG2/ARRB2/GNGT2/GNAI3	0.389638271713432
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/435	174/9376	1.11486325802616	UBE2J1/HSPA1B/RNF185/HSP90AB1/ERO1A/EDEM1/HSPA6/ATF4/UBE2D1	0.337327586873157
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/435	154/9376	1.1196895058964	TPM4/ATP2A3/TPM3/PLCB3/PLCB2/MYL4/ATF4/GNAI3	0.330324734683553
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/435	31/9376	1.39058212829069	CNDP2/ALDH2	0.480441794974822
NA	NA	hsa04382	Cornified envelope formation	11/435	217/9376	1.09260024365697	KRT19/KRT8/DSP/S100A6/KRT18/PKP3/KRT23/COL17A1/PLEC/S100A16/LAMC2	0.304407386237101
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/435	134/9376	1.12595642477269	MYL9/PPP1R12C/MYH9/RHOA/PLCB3/KCNMB1/PLCB2	0.323911942956803
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/435	12/9376	1.79616858237548	ASGR1	0.608698421648595
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	19/435	388/9376	1.0554805071691	GAPDH/TNF/TUBB6/TNFRSF1A/CYBB/COX7B2/IRS1/ATP2A3/IL1B/PLCB3/PLCB2/EIF2AK2/FRAT2/CSNK1E/CTNNB1/FRAT1/CASP8/ATF4/COX8C	0.246185218075219
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/435	53/9376	1.22003903708523	PLCB3/PLCB2/CLTB	0.354321126213856
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/435	138/9376	1.09332000666334	PYGL/SOCS3/IRS1/SH2B2/HK1/TRIP10/CRKL	0.243591732697301
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/435	480/9376	1.0327969348659	GPX3/TNFRSF1B/GPX1/TNF/TUBB6/TNFRSF1A/UBE2J1/CYBB/COX7B2/ATP2A3/LRRK2/IL1B/UBE2L6/PLCB3/PLCB2/FRAT2/CSNK1E/CTNNB1/FRAT1/CASP8/ATF4/COX8C/ATXN2L	0.162702305945524
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/435	98/9376	1.09969505043397	PIK3C2A/PLCB3/PIK3C2B/PLCB2/PIP4K2A	0.218824865597348
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/435	77/9376	1.1196895058964	TGFB1/RUNX1/TGFBR1/CRKL	0.232605795971435
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/435	184/9376	1.05427286356822	EFNB1/MYL9/CXCR4/RAC2/RHOA/CDC42/CFL1/SEMA4C/GNAI3	0.163992452026177
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/435	56/9376	1.15467980295567	ARRB2/CSNK1G2/CSNK1E	0.256068929981978
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/435	38/9376	1.13442226255293	NAMPT/NADK	0.183135814269733
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/435	38/9376	1.13442226255293	PTPRC/TAP1	0.183135814269733
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/435	105/9376	1.0263820470717	BNIP3L/PGAM5/RAB7A/RHOT2/ATF4	0.0599621324132384
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/435	83/9376	1.0387480958316	PCGF3/KDM2B/UBE2D1/RNF2	0.0782075465801797
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/435	83/9376	1.0387480958316	PRDX1/SOD2/CROT/FAR2	0.0782075465801797
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/435	17/9376	1.26788370520622	CYP39A1	0.2438334331317
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/435	217/9376	0.993272948779067	VEGFA/PTGES3/STAT3/HSP90AB1/RPS6KA1/ARRB2/CYP1B1/KLF4/ATF4/GNAI3	-0.0221140247409406
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/435	86/9376	1.0025126971398	PLCB3/KCNMB1/PLCB2/ATF4	0.00516319744635002
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/435	41/9376	1.05141575553687	VEGFA/CXCL8	0.0727726531004321
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/435	18/9376	1.19744572158365	PRDX1	0.184939499890765
NA	NA	hsa04082	Neuroactive ligand signaling	9/435	199/9376	0.974805059781667	GNG11/GNG2/OGFR/PLCB3/ADRA2C/PLCB2/GNGT2/HRH2/GNAI3	-0.0792367627229796
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/435	65/9376	0.994801061007958	PLCB3/ARRB2/PLCB2	-0.00927706192144469
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/435	42/9376	1.0263820470717	CYP1B1/ALDH2	0.0377951833968779
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/435	19/9376	1.13442226255293	HPSE	0.129365033707561
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/435	89/9376	0.968720134314865	ITGA4/ITGA5/CD44/LAMC2	-0.0653972338886736
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/435	89/9376	0.968720134314865	TUBB6/PLCB3/PLCB2/GNAI3	-0.0653972338886736
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/435	226/9376	0.953717831349812	MYL9/RAC2/HCAR3/VAV2/RHOA/ATP2A3/HCAR2/RAP1B/RAP1A/GNAI3	-0.155344038841554
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/435	44/9376	0.979728317659352	DYNLL1/ARHGDIB	-0.0297280200055088
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	10/435	227/9376	0.949516431211707	NCF1/NCF2/VEGFA/SOD2/HMOX1/CYBA/COX7B2/CYP1B1/SLC26A6/COX8C	-0.16982959836751
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/435	69/9376	0.937131434282858	PLCB3/PLCB2/GNAI3	-0.115608684686995
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/435	21/9376	1.0263820470717	CHST15	0.0266952173732551
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/435	21/9376	1.0263820470717	ALDH2	0.0266952173732551
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/435	93/9376	0.927054752193796	CDC42/PLCB3/PLCB2/ATF4	-0.155930661855489
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/435	46/9376	0.937131434282858	PSMB8/PSMB9	-0.0942776754154084
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/435	368/9376	0.937131434282858	GPX3/ACTG1/TNFRSF1B/ACTB/GPX1/TNF/TUBB6/HNRNPA1/TNFRSF1A/PFN1/CHCHD10/ALYREF/COX7B2/ATF4/COX8C/ATXN2L	-0.271381658527019
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/435	71/9376	0.91073336571151	SOCS3/STAT3/STAT1	-0.166531872487873
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/435	142/9376	0.91073336571151	SOCS3/BIRC3/UBE2J1/UBE2L6/UBE2D1/PIAS4	-0.236415320447386
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/435	23/9376	0.937131434282858	GLS	-0.0665823658199275
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/435	49/9376	0.879756040347173	ATF4/GNAI3	-0.186134784184052
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/435	122/9376	0.88336159788958	SCD/PFKFB3/PFKP/IRS1/LEP	-0.286018383883791
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/435	99/9376	0.870869615697202	CYP2J2/IL1B/PLCB3/PLCB2	-0.284891493377447
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/435	75/9376	0.86216091954023	BIRC3/ERCC1/CASP8	-0.264347614698578
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/435	101/9376	0.853624672812109	PLCB3/PLCB2/CTNNB1/GNAI3	-0.32621867981642
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/435	149/9376	0.867947234436473	GNG11/GNG2/PLCB3/PLCB2/GNGT2/GNAI3	-0.358383159720216
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/435	243/9376	0.886996830802706	HNRNPA1/HSPA1B/ALYREF/SRSF5/HSPA6/SART1/SRSF1/HNRNPU/HNRNPK/PCBP1	-0.393662685419267
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/435	150/9376	0.86216091954023	TGFB1/CTNNA1/TGFBR1/FRAT2/CTNNB1/FRAT1	-0.375360432508048
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/435	79/9376	0.818507202095155	STX3/ATP6V1B2/CLTB	-0.357304713362885
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/435	27/9376	0.798297147722435	SCD	-0.231498702393844
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/435	80/9376	0.808275862068965	VEGFA/STAT3/JAK1	-0.379848966314085
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/435	28/9376	0.769786535303777	ATP6V1B2	-0.26908383214882
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/435	82/9376	0.788561816652649	UPP1/CDA/IMPDH1	-0.424156600927904
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/435	110/9376	0.783782654127482	STK10/HSP90AB1/RPS6KA1/GNAI3	-0.503127372740866
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/435	30/9376	0.718467432950192	CYP2J2	-0.340654082913512
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/435	85/9376	0.760730223123732	UPP1/CDA/IMPDH1	-0.488768598810129
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/435	59/9376	0.730644847067991	UPP1/CDA	-0.457773307484831
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/435	59/9376	0.730644847067991	GPX3/GPX1	-0.457773307484831
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/435	59/9376	0.730644847067991	IRS1/GNAI3	-0.457773307484831
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/435	59/9376	0.730644847067991	CTNNA1/CTNNB1	-0.457773307484831
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/435	31/9376	0.695291064145347	ALDH2	-0.374812100921121
NA	NA	hsa04981	Folate transport and metabolism	1/435	31/9376	0.695291064145347	ABCC3	-0.374812100921121
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/435	32/9376	0.673563218390805	LDHA	-0.407985643365975
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/435	90/9376	0.718467432950192	SOD2/IRS1/ATF4	-0.591933302876849
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/435	63/9376	0.684254698047801	COLGALT1/ALDH2	-0.554625189094164
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/435	63/9376	0.684254698047801	CYP2J2/PTGES3	-0.554625189094164
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/435	65/9376	0.663200707338638	AGPAT2/ALDH2	-0.600989528421202
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/435	93/9376	0.695291064145347	LYZ/PLCB3/PLCB2	-0.651357935849748
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/435	36/9376	0.598722860791826	UGP2	-0.532058578916634
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/435	36/9376	0.598722860791826	GALNT7	-0.532058578916634
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/435	148/9376	0.728176452314383	NFKB2/NOTCH1/FRAT2/CTNNB1/FRAT1	-0.735192994923296
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/435	37/9376	0.582541161851507	GLS	-0.561179184526424
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/435	68/9376	0.63394185260311	RDH13/ALDH1A1	-0.668210915471479
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/435	38/9376	0.567211131276467	IRS1	-0.58962808968752
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/435	254/9376	0.763725224002172	CXCR4/VEGFA/CAMK1/PTAFR/ATP2A3/PLCB3/PLCB2/FLT1/HRH2	-0.842027748609965
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/435	39/9376	0.552667256115532	ATIC	-0.617442517800274
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/435	154/9376	0.699805941185251	RDH13/UGP2/RFK/ALDH2/NADK	-0.828489699985814
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/435	128/9376	0.673563218390805	PGM2/IMPDH1/PRPS2/ATIC	-0.820195497636393
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/435	73/9376	0.590521177767281	STAT3/RASSF5	-0.774673293796831
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/435	103/9376	0.627787077335119	ALYREF/ETF1/NUDT21	-0.837793812939513
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/435	103/9376	0.627787077335119	SLC7A7/COL17A1/KCNE3	-0.837793812939513
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/435	104/9376	0.621750663129973	AGPAT2/LPCAT1/PNPLA6	-0.855549915465867
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/435	75/9376	0.574773946360153	IGFBP3/CASP8	-0.815497989484852
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/435	43/9376	0.501256348569901	ALDH2	-0.722999829127634
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/435	43/9376	0.501256348569901	AGPAT2	-0.722999829127634
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/435	76/9376	0.567211131276467	PLIN2/SCD	-0.835561889547593
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/435	106/9376	0.610019518542615	HSP90AB1/CTNNB1/ATF4	-0.890621460878065
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/435	78/9376	0.552667256115532	ENO1/PFKP	-0.875024954153249
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/435	108/9376	0.598722860791826	EEF1A1/ALYREF/SUMO3	-0.925125182876128
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/435	370/9376	0.757303510406959	TSPO/GH2/NPB/PTAFR/C5AR1/FPR3/OGFR/CHRNB1/FPR1/ADRA2C/LEP/FPR2/HRH2	-1.05059566535576
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/435	48/9376	0.44904214559387	ALDH2	-0.844076769600055
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/435	144/9376	0.598722860791826	ATP2A3/PLCB3/PLCB2/ATXN2L	-1.07032331548995
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/435	51/9376	0.422627901735407	LPCAT1	-0.911913572604291
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	10/435	308/9376	0.699805941185251	GPX3/SOD2/GPX1/TUBB6/COX7B2/PLCB3/PLCB2/CASP8/COX8C/CLTB	-1.18156852767416
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/435	86/9376	0.501256348569901	EREG/CRKL	-1.02483976546807
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/435	86/9376	0.501256348569901	PLCB3/PLCB2	-1.02483976546807
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/435	52/9376	0.414500442086649	TSPO	-0.933822492012248
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/435	54/9376	0.399148573861217	LDHA	-0.976667297553234
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/435	54/9376	0.399148573861217	ERCC1	-0.976667297553234
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/435	90/9376	0.478978288633461	AQP9/ABCC3	-1.09546865469805
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/435	55/9376	0.391891327063741	PSAP	-0.997627718892814
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/435	57/9376	0.378140754184311	SCD	-1.0386807599402
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/435	93/9376	0.463527376096898	BIRC3/LAMC2	-1.14678520984401
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	8/435	268/9376	0.643403671298679	TUBB6/UBE2J1/COX7B2/LRRK2/UBE2L6/ATF4/COX8C/GNAI3	-1.30638135348645
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/435	191/9376	0.564241439489679	GNG11/GNG2/GNGT2/ATF4/GNAI3	-1.34202389980064
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/435	99/9376	0.435434807848601	RAC2/WAS	-1.24556138796725
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/435	63/9376	0.342127349023901	ERCC1	-1.15559199516684
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/435	63/9376	0.342127349023901	CTNNB1	-1.15559199516684
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/435	138/9376	0.468565717141429	COX7B2/ATP6V1B2/COX8C	-1.38719447634939
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/435	69/9376	0.312377144760953	ATF4	-1.26446615964753
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/435	70/9376	0.307914614121511	CYP1B1	-1.2819302443566
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/435	235/9376	0.550315480557593	ACTG1/ACTB/SMARCD3/COX7B2/RPS6KA1/COX8C	-1.53986352882799
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/435	76/9376	0.283605565638234	CAMK1	-1.38310370366545
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/435	79/9376	0.272835734031718	CYP1B1	-1.43156765788442
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/435	169/9376	0.382615792695368	IRS1/RAB7A/DDIT4	-1.78639303175127
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/435	99/9376	0.217717403924301	NOTCH1	-1.72589633526215
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/435	183/9376	0.353344639155832	GNL2/GNL3/NAT10	-1.94852963946651
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/435	138/9376	0.156188572380476	RPS6KA1	-2.20258758087274
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/435	158/9376	0.136417867015859	TGFB1	-2.41463259732691
Genetic Information Processing	Translation	hsa03010	Ribosome	1/435	222/9376	0.0970901936419178	RPL4	-3.00298126179932
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/435	449/9376	0.0480045055423291	ARRB2	-4.55976557385711