ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 58/787 443/18639 0.130925507900677 3.1007884901661 1.52456971821638e-14 1.48035719638811e-11 GO:0045296 cadherin binding 46/787 334/18639 0.137724550898204 3.26181436364881 1.44092342919334e-12 6.99568324873368e-10 GO:0051015 actin filament binding 31/787 209/18639 0.148325358851675 3.51287975049093 1.07156098372532e-09 3.4682857173243e-07 GO:0140375 immune receptor activity 24/787 156/18639 0.153846153846154 3.64363209852409 3.98470464508677e-08 9.67287052594813e-06 GO:0042605 peptide antigen binding 12/787 45/18639 0.266666666666667 6.3156289707751 2.34923693451591e-07 4.5622181268299e-05 GO:0023023 MHC protein complex binding 10/787 37/18639 0.27027027027027 6.400975308218 2.09960386012895e-06 0.000339785891364202 GO:0001784 phosphotyrosine residue binding 11/787 47/18639 0.234042553191489 5.54297223498878 3.06757027570265e-06 0.000425515819672468 GO:0003924 GTPase activity 33/787 331/18639 0.0996978851963746 2.36120569526712 4.58558401195496e-06 0.000556575259451034 GO:0023026 MHC class II protein complex binding 8/787 27/18639 0.296296296296296 7.01736552308344 1.05854114666474e-05 0.0011420482815683 GO:0003725 double-stranded RNA binding 13/787 75/18639 0.173333333333333 4.10515883100381 1.37863827123402e-05 0.00130991638778971 GO:0140313 molecular sequestering activity 11/787 55/18639 0.2 4.73672172808132 1.54841102738982e-05 0.00130991638778971 GO:0005126 cytokine receptor binding 28/787 275/18639 0.101818181818182 2.41142197065958 1.6188462053014e-05 0.00130991638778971 GO:0045309 protein phosphorylated amino acid binding 11/787 59/18639 0.186440677966102 4.41558805160123 3.10538231057899e-05 0.00231948171044016 GO:0048027 mRNA 5'-UTR binding 7/787 24/18639 0.291666666666667 6.90771918678526 4.29254328248665e-05 0.00297718537663896 GO:0019956 chemokine binding 8/787 33/18639 0.242424242424242 5.74148088252281 5.28662449320436e-05 0.00342220825526763 GO:0032396 inhibitory MHC class I receptor activity 5/787 13/18639 0.384615384615385 9.10908024631023 0.000128471218438532 0.00739887509662579 GO:0043024 ribosomal small subunit binding 6/787 20/18639 0.3 7.10508259212198 0.000129537463071718 0.00739887509662579 GO:0051219 phosphoprotein binding 13/787 93/18639 0.139784946236559 3.31061196048694 0.000140599064059431 0.00758453840009484 GO:0005525 GTP binding 32/787 378/18639 0.0846560846560847 2.00496157802384 0.000156171770448904 0.00798119942662558 GO:0004857 enzyme inhibitor activity 34/787 416/18639 0.0817307692307692 1.93567955234092 0.000192544761101074 0.00854362645301682 GO:0019001 guanyl nucleotide binding 33/787 400/18639 0.0825 1.95389771283355 0.000200397227671659 0.00854362645301682 GO:0032561 guanyl ribonucleotide binding 33/787 400/18639 0.0825 1.95389771283355 0.000200397227671659 0.00854362645301682 GO:0001968 fibronectin binding 7/787 30/18639 0.233333333333333 5.52617534942821 0.000202372202285671 0.00854362645301682 GO:0140517 protein-RNA adaptor activity 6/787 22/18639 0.272727272727273 6.45916599283817 0.000231956367970117 0.00938456805412433 GO:0005200 structural constituent of cytoskeleton 14/787 112/18639 0.125 2.96045108005083 0.000264211426381732 0.0102619718006665 GO:0005080 protein kinase C binding 9/787 52/18639 0.173076923076923 4.0990861108396 0.000293108662246998 0.0105854805485198 GO:0019003 GDP binding 11/787 75/18639 0.146666666666667 3.4735959339263 0.000294343949340922 0.0105854805485198 GO:0030246 carbohydrate binding 25/787 280/18639 0.0892857142857143 2.11460791432202 0.000360750260693114 0.0125103036833219 GO:0019957 C-C chemokine binding 6/787 24/18639 0.25 5.92090216010165 0.000389275391011532 0.0126019784054007 GO:0019955 cytokine binding 16/787 144/18639 0.111111111111111 2.63151207115629 0.000389350517159651 0.0126019784054007 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/787 10/18639 0.4 9.47344345616264 0.000540103086497076 0.0169174224835052 GO:0044389 ubiquitin-like protein ligase binding 27/787 322/18639 0.0838509316770186 1.98589264997198 0.000575044929985808 0.0170482255967528 GO:0001618 virus receptor activity 11/787 81/18639 0.135802469135802 3.21629253141324 0.000579393866830939 0.0170482255967528 GO:0140272 exogenous protein binding 11/787 82/18639 0.134146341463415 3.17706945176186 0.000644122406022016 0.0183953781249229 GO:0097110 scaffold protein binding 10/787 70/18639 0.142857142857143 3.38337266291523 0.000680010362045757 0.018865430329898 GO:0032393 MHC class I receptor activity 5/787 18/18639 0.277777777777778 6.57878017789072 0.000717155747066739 0.0193432841778279 GO:0005536 D-glucose binding 4/787 11/18639 0.363636363636364 8.61222132378422 0.000820449185763127 0.0204522294405349 GO:0042608 T cell receptor binding 4/787 11/18639 0.363636363636364 8.61222132378422 0.000820449185763127 0.0204522294405349 GO:0038187 pattern recognition receptor activity 8/787 48/18639 0.166666666666667 3.94726810673443 0.000821459266921589 0.0204522294405349 GO:0001222 transcription corepressor binding 8/787 49/18639 0.163265306122449 3.86671161476026 0.000945985825158288 0.0229638059057174 GO:0032813 tumor necrosis factor receptor superfamily binding 8/787 50/18639 0.16 3.78937738246506 0.00108517891912706 0.0257002129383507 GO:0017124 SH3 domain binding 13/787 115/18639 0.11304347826087 2.67727749848075 0.0011324056220246 0.0257351859389671 GO:0003823 antigen binding 17/787 174/18639 0.0977011494252874 2.31391578670639 0.00113966322901708 0.0257351859389671 GO:0004875 complement receptor activity 4/787 12/18639 0.333333333333333 7.89453621346887 0.00118972217236548 0.0261039225774384 GO:0042288 MHC class I protein binding 5/787 20/18639 0.25 5.92090216010165 0.00120975954272372 0.0261039225774384 GO:0061791 GTPase motor activity 7/787 40/18639 0.175 4.14463151207116 0.00128428182993615 0.0265327161035746 GO:1990606 membrane scission GTPase motor activity 7/787 40/18639 0.175 4.14463151207116 0.00128428182993615 0.0265327161035746 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/787 21/18639 0.238095238095238 5.63895443819205 0.00153315099155879 0.0310143669334081 GO:0005164 tumor necrosis factor receptor binding 6/787 31/18639 0.193548387096774 4.58392425298192 0.0016554316824704 0.0328045747689543 GO:0033691 sialic acid binding 5/787 22/18639 0.227272727272727 5.38263832736514 0.00191585529261429 0.0372059097825695 GO:0008191 metalloendopeptidase inhibitor activity 4/787 14/18639 0.285714285714286 6.76674532583046 0.00224878015034221 0.0417345924124675 GO:0032036 myosin heavy chain binding 4/787 14/18639 0.285714285714286 6.76674532583046 0.00224878015034221 0.0417345924124675 GO:0140311 protein sequestering activity 6/787 33/18639 0.181818181818182 4.30611066189211 0.00231802764434084 0.0417345924124675 GO:0031625 ubiquitin protein ligase binding 24/787 302/18639 0.0794701986754967 1.88214108400582 0.00232653430774768 0.0417345924124675 GO:0016493 C-C chemokine receptor activity 5/787 23/18639 0.217391304347826 5.14861057400144 0.00236395734571134 0.0417345924124675 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/787 45/18639 0.155555555555556 3.68411689961881 0.00260482615484711 0.0451658249349382 GO:0005154 epidermal growth factor receptor binding 6/787 35/18639 0.171428571428571 4.06004719549828 0.00316262239394916 0.0536695353334981 GO:0042379 chemokine receptor binding 9/787 72/18639 0.125 2.96045108005083 0.00320580128665591 0.0536695353334981 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/787 16/18639 0.25 5.92090216010165 0.0038225027692292 0.0625345234799914 GO:0048029 monosaccharide binding 9/787 74/18639 0.121621621621622 2.8804388886981 0.00386413121400565 0.0625345234799914 GO:0051020 GTPase binding 24/787 315/18639 0.0761904761904762 1.80446542022146 0.00398655581139664 0.0634581261125596 GO:0001637 G protein-coupled chemoattractant receptor activity 5/787 26/18639 0.192307692307692 4.55454012315512 0.00416229624438999 0.0641522167190901 GO:0004950 chemokine receptor activity 5/787 26/18639 0.192307692307692 4.55454012315512 0.00416229624438999 0.0641522167190901 GO:0042277 peptide binding 20/787 249/18639 0.0803212851405622 1.90229788276358 0.00459170953759248 0.0696648431406608 GO:0045236 CXCR chemokine receptor binding 4/787 17/18639 0.235294117647059 5.57261379774273 0.00483358828550868 0.0722063726958297 GO:0005125 cytokine activity 19/787 234/18639 0.0811965811965812 1.92302805199883 0.00503149041431353 0.0740238968530067 GO:0097718 disordered domain specific binding 5/787 28/18639 0.178571428571429 4.22921582864404 0.00580108269243186 0.0837614713244717 GO:0038024 cargo receptor activity 8/787 65/18639 0.123076923076923 2.91490567881927 0.00586589088575085 0.0837614713244717 GO:0098641 cadherin binding involved in cell-cell adhesion 4/787 18/18639 0.222222222222222 5.26302414231258 0.00600971186792067 0.08457145251813 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/787 40/18639 0.15 3.55254129606099 0.00625798460045912 0.0868071863863686 GO:0003785 actin monomer binding 5/787 29/18639 0.172413793103448 4.08338080007011 0.00677057756936189 0.0893528031888929 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/787 29/18639 0.172413793103448 4.08338080007011 0.00677057756936189 0.0893528031888929 GO:0042287 MHC protein binding 6/787 41/18639 0.146341463414634 3.46589394737658 0.00707481594437326 0.0893528031888929 GO:0005543 phospholipid binding 33/787 497/18639 0.0663983903420523 1.57255349121412 0.00710632882431423 0.0893528031888929 GO:0005522 profilin binding 3/787 10/18639 0.3 7.10508259212198 0.0072015412028584 0.0893528031888929 GO:0032395 MHC class II receptor activity 3/787 10/18639 0.3 7.10508259212198 0.0072015412028584 0.0893528031888929 GO:0043208 glycosphingolipid binding 3/787 10/18639 0.3 7.10508259212198 0.0072015412028584 0.0893528031888929 GO:0043422 protein kinase B binding 3/787 10/18639 0.3 7.10508259212198 0.0072015412028584 0.0893528031888929 GO:0003925 G protein activity 7/787 54/18639 0.12962962962963 3.070097416349 0.0073335669774012 0.0893528031888929 GO:0034987 immunoglobulin receptor binding 4/787 19/18639 0.210526315789474 4.98602287166455 0.00736171395994998 0.0893528031888929 GO:0061134 peptidase regulator activity 18/787 226/18639 0.079646017699115 1.88630511295274 0.00755252475761533 0.0905370560449937 GO:0043022 ribosome binding 11/787 112/18639 0.0982142857142857 2.32606870575422 0.00774435111951833 0.0907183900149104 GO:0001664 G protein-coupled receptor binding 22/787 297/18639 0.0740740740740741 1.75434138077086 0.00782652998246147 0.0907183900149104 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/787 30/18639 0.166666666666667 3.94726810673443 0.00784793487255661 0.0907183900149104 GO:0004866 endopeptidase inhibitor activity 14/787 161/18639 0.0869565217391304 2.05944422960057 0.00838652433349355 0.0946897107886307 GO:0005178 integrin binding 14/787 161/18639 0.0869565217391304 2.05944422960057 0.00838652433349355 0.0946897107886307 GO:0031267 small GTPase binding 21/787 283/18639 0.0742049469964664 1.75744092384643 0.00905186123930289 0.100174318695702 GO:0001221 transcription coregulator binding 11/787 115/18639 0.0956521739130435 2.26538865256063 0.00937933935530619 0.100174318695702 GO:0035401 histone H3Y41 kinase activity 11/787 115/18639 0.0956521739130435 2.26538865256063 0.00937933935530619 0.100174318695702 GO:0140801 histone H2AXY142 kinase activity 11/787 115/18639 0.0956521739130435 2.26538865256063 0.00937933935530619 0.100174318695702 GO:0140996 histone H3 kinase activity 25/787 357/18639 0.0700280112044818 1.65851601123296 0.00953131974737806 0.100174318695702 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/787 11/18639 0.272727272727273 6.45916599283817 0.00959445070926913 0.100174318695702 GO:0019864 IgG binding 3/787 11/18639 0.272727272727273 6.45916599283817 0.00959445070926913 0.100174318695702 GO:0030695 GTPase regulator activity 32/787 489/18639 0.065439672801636 1.54984760019021 0.00971957957168166 0.100401188979818 GO:0060589 nucleoside-triphosphatase regulator activity 32/787 490/18639 0.0653061224489796 1.54668464590411 0.00999453037113163 0.102154620951251 GO:0035173 histone kinase activity 25/787 360/18639 0.0694444444444444 1.64469504447268 0.0105191305786944 0.106396622832419 GO:0008009 chemokine activity 6/787 45/18639 0.133333333333333 3.15781448538755 0.0111213567811896 0.111328220974588 GO:0061135 endopeptidase regulator activity 15/787 184/18639 0.0815217391304348 1.93072896525054 0.0114553717590432 0.113501693653377 GO:1901981 phosphatidylinositol phosphate binding 15/787 185/18639 0.0810810810810811 1.9202925924654 0.011997392983264 0.117671399866155 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/787 12/18639 0.25 5.92090216010165 0.012396026888237 0.120365421084781 GO:0030414 peptidase inhibitor activity 14/787 169/18639 0.0828402366863905 1.96195574535913 0.0125315556123508 0.120476638609828 GO:0003727 single-stranded RNA binding 9/787 89/18639 0.101123595505618 2.39497166026584 0.0127465166292547 0.121341839676532 GO:0043495 protein-membrane adaptor activity 6/787 47/18639 0.127659574468085 3.02343940090297 0.0136605712919048 0.128780725479996 GO:0005539 glycosaminoglycan binding 18/787 242/18639 0.0743801652892562 1.7615907253195 0.0145921575474618 0.136240240178706 GO:0070851 growth factor receptor binding 12/787 139/18639 0.0863309352517986 2.04462808406388 0.0147899087345919 0.136771441726559 GO:0005172 vascular endothelial growth factor receptor binding 3/787 13/18639 0.230769230769231 5.46544814778614 0.0156164181758082 0.138577320074895 GO:0071714 icosanoid transmembrane transporter activity 3/787 13/18639 0.230769230769231 5.46544814778614 0.0156164181758082 0.138577320074895 GO:0140666 annealing activity 3/787 13/18639 0.230769230769231 5.46544814778614 0.0156164181758082 0.138577320074895 GO:0140852 histone ubiquitin ligase activity 3/787 13/18639 0.230769230769231 5.46544814778614 0.0156164181758082 0.138577320074895 GO:0141003 histone H2AX kinase activity 24/787 354/18639 0.0677966101694915 1.60566838240045 0.0156987695244474 0.138577320074895 GO:0035091 phosphatidylinositol binding 20/787 284/18639 0.0704225352112676 1.66785976340892 0.0179959635919294 0.15704596448466 GO:0043021 ribonucleoprotein complex binding 14/787 177/18639 0.0790960451977401 1.87327977946719 0.0181144675821647 0.15704596448466 GO:0005161 platelet-derived growth factor receptor binding 3/787 14/18639 0.214285714285714 5.07505899437284 0.0192621376372989 0.162639440398411 GO:0019763 immunoglobulin receptor activity 3/787 14/18639 0.214285714285714 5.07505899437284 0.0192621376372989 0.162639440398411 GO:1990825 sequence-specific mRNA binding 3/787 14/18639 0.214285714285714 5.07505899437284 0.0192621376372989 0.162639440398411 GO:0048306 calcium-dependent protein binding 8/787 80/18639 0.1 2.36836086404066 0.0194779640478195 0.163043992158903 GO:0004896 cytokine receptor activity 9/787 96/18639 0.09375 2.22033831003812 0.0200945142599856 0.166767293559368 GO:0043531 ADP binding 5/787 38/18639 0.131578947368421 3.11626429479034 0.020981974591524 0.172656757020083 GO:0051371 muscle alpha-actinin binding 3/787 15/18639 0.2 4.73672172808132 0.0233364371127995 0.190417482659902 GO:0051018 protein kinase A binding 6/787 53/18639 0.113207547169811 2.68116324231018 0.0236465706210881 0.191340167275638 GO:1990841 promoter-specific chromatin binding 7/787 68/18639 0.102941176470588 2.43801853651244 0.0242708310733984 0.194768404729503 GO:0008395 steroid hydroxylase activity 4/787 27/18639 0.148148148148148 3.50868276154172 0.0255528825332033 0.203375810981479 GO:0140297 DNA-binding transcription factor binding 30/787 488/18639 0.0614754098360656 1.45595954756598 0.0259359562440516 0.204746451324992 GO:0098632 cell-cell adhesion mediator activity 6/787 55/18639 0.109090909090909 2.58366639713527 0.0278384611865371 0.214542085725085 GO:0005521 lamin binding 3/787 16/18639 0.1875 4.44067662007624 0.0278396527305465 0.214542085725085 GO:0070411 I-SMAD binding 3/787 16/18639 0.1875 4.44067662007624 0.0278396527305465 0.214542085725085 GO:0051393 alpha-actinin binding 4/787 28/18639 0.142857142857143 3.38337266291523 0.0288448491733319 0.220240391026153 GO:0002020 protease binding 11/787 136/18639 0.0808823529411765 1.91558599297406 0.0292595370158329 0.220240391026153 GO:0044325 transmembrane transporter binding 11/787 136/18639 0.0808823529411765 1.91558599297406 0.0292595370158329 0.220240391026153 GO:0008307 structural constituent of muscle 5/787 42/18639 0.119047619047619 2.81947721909602 0.0310140226390837 0.231650892173464 GO:0051861 glycolipid binding 4/787 29/18639 0.137931034482759 3.26670464005608 0.0323767326299671 0.237456772360045 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/787 17/18639 0.176470588235294 4.17946034830705 0.0327695236830546 0.237456772360045 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/787 17/18639 0.176470588235294 4.17946034830705 0.0327695236830546 0.237456772360045 GO:0046965 nuclear retinoid X receptor binding 3/787 17/18639 0.176470588235294 4.17946034830705 0.0327695236830546 0.237456772360045 GO:0035402 histone H3T11 kinase activity 17/787 247/18639 0.0688259109311741 1.63004593881341 0.0333692271984036 0.240011256367777 GO:0061980 regulatory RNA binding 6/787 58/18639 0.103448275862069 2.45002848004206 0.0349989742750707 0.245524805777909 GO:0004713 protein tyrosine kinase activity 11/787 140/18639 0.0785714285714286 1.86085496460338 0.0351137772182697 0.245524805777909 GO:0000287 magnesium ion binding 16/787 230/18639 0.0695652173913043 1.64755538368046 0.0351472173049736 0.245524805777909 GO:0005085 guanyl-nucleotide exchange factor activity 16/787 230/18639 0.0695652173913043 1.64755538368046 0.0351472173049736 0.245524805777909 GO:0008187 poly-pyrimidine tract binding 4/787 30/18639 0.133333333333333 3.15781448538755 0.0361503938234149 0.250728802875256 GO:0070064 proline-rich region binding 3/787 18/18639 0.166666666666667 3.94726810673443 0.0381214860460814 0.262105232769346 GO:0020037 heme binding 11/787 142/18639 0.0774647887323944 1.83464573974981 0.0383305283761556 0.262105232769346 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 22/787 349/18639 0.0630372492836676 1.49294954180214 0.0405545176055705 0.27537368248258 GO:0017022 myosin binding 7/787 76/18639 0.0921052631578947 2.18138500635324 0.041171269329126 0.277620156379037 GO:0019903 protein phosphatase binding 11/787 144/18639 0.0763888888888889 1.80916454891995 0.0417473187365548 0.279563079263412 GO:0042826 histone deacetylase binding 10/787 127/18639 0.078740157480315 1.86485107404776 0.0427035082018189 0.284007578520316 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/787 46/18639 0.108695652173913 2.57430528700072 0.0436202364761556 0.285684163845879 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/787 19/18639 0.157894736842105 3.73951715374841 0.043888943312231 0.285684163845879 GO:0042834 peptidoglycan binding 3/787 19/18639 0.157894736842105 3.73951715374841 0.043888943312231 0.285684163845879 GO:0043425 bHLH transcription factor binding 4/787 32/18639 0.125 2.96045108005083 0.04442668253422 0.285684163845879 GO:0051059 NF-kappaB binding 4/787 32/18639 0.125 2.96045108005083 0.04442668253422 0.285684163845879 GO:0035591 signaling adaptor activity 10/787 129/18639 0.0775193798449612 1.83593865429509 0.0466608915908994 0.298077142991864 GO:0046332 SMAD binding 7/787 79/18639 0.0886075949367089 2.09854760104869 0.0490895593012154 0.311294848790148 GO:1901682 sulfur compound transmembrane transporter activity 6/787 63/18639 0.0952380952380952 2.25558177527682 0.049371170662907 0.311294848790148 GO:0015101 organic cation transmembrane transporter activity 7/787 81/18639 0.0864197530864197 2.04673161089934 0.0548697089781953 0.343732176889211 GO:0019200 carbohydrate kinase activity 3/787 21/18639 0.142857142857143 3.38337266291523 0.0566352662743118 0.348055971850359 GO:0070182 DNA polymerase binding 3/787 21/18639 0.142857142857143 3.38337266291523 0.0566352662743118 0.348055971850359 GO:0072542 protein phosphatase activator activity 3/787 21/18639 0.142857142857143 3.38337266291523 0.0566352662743118 0.348055971850359 GO:0046906 tetrapyrrole binding 11/787 152/18639 0.0723684210526316 1.71394536213469 0.0575047459991831 0.351176782171112 GO:0048020 CCR chemokine receptor binding 5/787 50/18639 0.1 2.36836086404066 0.0588945680149635 0.35741640964081 GO:0019902 phosphatase binding 13/787 190/18639 0.068421052631579 1.62045743329098 0.0597660660005797 0.358846126716162 GO:0008135 translation factor activity, RNA binding 7/787 83/18639 0.0843373493975904 1.99741277690176 0.0610568248490545 0.358846126716162 GO:0019207 kinase regulator activity 18/787 287/18639 0.0627177700348432 1.48538312030425 0.0619135194284949 0.358846126716162 GO:0005506 iron ion binding 11/787 154/18639 0.0714285714285714 1.69168633145761 0.0619856363210203 0.358846126716162 GO:0050840 extracellular matrix binding 6/787 67/18639 0.0895522388059701 2.12092017675283 0.0631393940544644 0.358846126716162 GO:0005031 tumor necrosis factor receptor activity 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0005131 growth hormone receptor binding 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0005345 purine nucleobase transmembrane transporter activity 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0005381 iron ion transmembrane transporter activity 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0030957 Tat protein binding 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0071723 lipopeptide binding 2/787 10/18639 0.2 4.73672172808132 0.0639881796677315 0.358846126716162 GO:0180051 translation factor activity 7/787 84/18639 0.0833333333333333 1.97363405336722 0.064304043304441 0.358846126716162 GO:0015171 amino acid transmembrane transporter activity 8/787 102/18639 0.0784313725490196 1.85753793258091 0.0667291812100886 0.370251628314263 GO:0005096 GTPase activator activity 17/787 271/18639 0.0627306273062731 1.48568762688898 0.0680455222408475 0.373078183924601 GO:0042805 actinin binding 4/787 37/18639 0.108108108108108 2.5603901232872 0.0693382148632476 0.373078183924601 GO:0043394 proteoglycan binding 4/787 37/18639 0.108108108108108 2.5603901232872 0.0693382148632476 0.373078183924601 GO:0031681 G-protein beta-subunit binding 3/787 23/18639 0.130434782608696 3.08916634440086 0.0709240288548626 0.373078183924601 GO:0042171 lysophosphatidic acid acyltransferase activity 3/787 23/18639 0.130434782608696 3.08916634440086 0.0709240288548626 0.373078183924601 GO:0071617 lysophospholipid acyltransferase activity 3/787 23/18639 0.130434782608696 3.08916634440086 0.0709240288548626 0.373078183924601 GO:0004674 protein serine/threonine kinase activity 25/787 433/18639 0.0577367205542725 1.36741389378791 0.0712099749039926 0.373078183924601 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/787 70/18639 0.0857142857142857 2.03002359774914 0.0748068880594839 0.373078183924601 GO:0019887 protein kinase regulator activity 16/787 255/18639 0.0627450980392157 1.48603034606473 0.07484936397613 0.373078183924601 GO:0000099 sulfur amino acid transmembrane transporter activity 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0005114 type II transforming growth factor beta receptor binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0008199 ferric iron binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0008271 secondary active sulfate transmembrane transporter activity 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0015173 aromatic amino acid transmembrane transporter activity 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0015205 nucleobase transmembrane transporter activity 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0034713 type I transforming growth factor beta receptor binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0045294 alpha-catenin binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0048185 activin binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0050998 nitric-oxide synthase binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0140031 phosphorylation-dependent protein binding 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0140537 transcription regulator activator activity 2/787 11/18639 0.181818181818182 4.30611066189211 0.0760756749918342 0.373078183924601 GO:0015485 cholesterol binding 5/787 54/18639 0.0925925925925926 2.19292672596357 0.0768482786457686 0.374973259120811 GO:0004497 monooxygenase activity 8/787 106/18639 0.0754716981132075 1.78744216154012 0.0795836396457006 0.384206009974089 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 12/787 181/18639 0.0662983425414365 1.570183998259 0.0823223637875975 0.384206009974089 GO:0019211 phosphatase activator activity 3/787 25/18639 0.12 2.84203303684879 0.0866521834162364 0.384206009974089 GO:0042974 nuclear retinoic acid receptor binding 3/787 25/18639 0.12 2.84203303684879 0.0866521834162364 0.384206009974089 GO:0170055 lipid transmembrane transporter activity 5/787 56/18639 0.0892857142857143 2.11460791432202 0.0868122285756354 0.384206009974089 GO:0106310 protein serine kinase activity 21/787 361/18639 0.0581717451523546 1.37771684611784 0.0868174396469137 0.384206009974089 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/787 40/18639 0.1 2.36836086404066 0.0870835977816085 0.384206009974089 GO:0004126 cytidine deaminase activity 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0004859 phospholipase inhibitor activity 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0015132 prostaglandin transmembrane transporter activity 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0017166 vinculin binding 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0035197 siRNA binding 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0035259 nuclear glucocorticoid receptor binding 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0070008 serine-type exopeptidase activity 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0097677 STAT family protein binding 2/787 12/18639 0.166666666666667 3.94726810673443 0.0888116046125536 0.384206009974089 GO:0015103 inorganic anion transmembrane transporter activity 11/787 165/18639 0.0666666666666667 1.57890724269377 0.0906600176443643 0.384206009974089 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 15/787 243/18639 0.0617283950617284 1.46195115064238 0.091677825931816 0.384206009974089 GO:0031490 chromatin DNA binding 9/787 128/18639 0.0703125 1.66525373252859 0.0924383550782596 0.384206009974089 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/787 41/18639 0.0975609756097561 2.31059596491772 0.0934418014330089 0.384206009974089 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/787 41/18639 0.0975609756097561 2.31059596491772 0.0934418014330089 0.384206009974089 GO:0042169 SH2 domain binding 4/787 41/18639 0.0975609756097561 2.31059596491772 0.0934418014330089 0.384206009974089 GO:0004435 phosphatidylinositol phospholipase C activity 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0005160 transforming growth factor beta receptor binding 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0008157 protein phosphatase 1 binding 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0019865 immunoglobulin binding 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0030507 spectrin binding 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0043548 phosphatidylinositol 3-kinase binding 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0052742 phosphatidylinositol kinase activity 3/787 26/18639 0.115384615384615 2.73272407389307 0.0950200969391817 0.384206009974089 GO:0004676 3-phosphoinositide-dependent protein kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0004711 ribosomal protein S6 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0035175 histone H3S10 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0035979 histone H2AXS139 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0044022 histone H3S28 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0044023 histone H4S1 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0044024 histone H2AS1 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0044025 histone H2BS14 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0072354 histone H3T3 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0072371 histone H2AS121 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0072518 Rho-dependent protein serine/threonine kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0140823 histone H2BS36 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0140855 histone H3S57 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0140995 histone H2A kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0140997 histone H4 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0140998 histone H2B kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:1990244 histone H2AT120 kinase activity 15/787 245/18639 0.0612244897959184 1.4500168555351 0.0965461034332417 0.384206009974089 GO:0004677 DNA-dependent protein kinase activity 15/787 246/18639 0.0609756097560976 1.44412247807357 0.0990394646279554 0.390924065665629 GO:0140857 histone H3T45 kinase activity 15/787 246/18639 0.0609756097560976 1.44412247807357 0.0990394646279554 0.390924065665629 GO:0035198 miRNA binding 4/787 42/18639 0.0952380952380952 2.25558177527682 0.100013146569212 0.391583731123809 GO:0042056 chemoattractant activity 4/787 42/18639 0.0952380952380952 2.25558177527682 0.100013146569212 0.391583731123809 GO:0098631 cell adhesion mediator activity 6/787 76/18639 0.0789473684210526 1.86975857687421 0.101548191165139 0.391930219520965 GO:0035403 histone H3T6 kinase activity 15/787 247/18639 0.0607287449392713 1.43827582836477 0.10157231945573 0.391930219520965 GO:0046943 carboxylic acid transmembrane transporter activity 12/787 188/18639 0.0638297872340425 1.51171970045149 0.101735405048421 0.391930219520965 GO:0005035 death receptor activity 2/787 13/18639 0.153846153846154 3.64363209852409 0.102119820328326 0.391930219520965 GO:0035325 Toll-like receptor binding 2/787 13/18639 0.153846153846154 3.64363209852409 0.102119820328326 0.391930219520965 GO:0001786 phosphatidylserine binding 5/787 59/18639 0.0847457627118644 2.00708547800056 0.102952109741701 0.392045851525609 GO:0031072 heat shock protein binding 9/787 131/18639 0.0687022900763359 1.62711815086763 0.102957458433605 0.392045851525609 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/787 27/18639 0.111111111111111 2.63151207115629 0.103703498739929 0.393344129986215 GO:0004679 AMP-activated protein kinase activity 15/787 248/18639 0.0604838709677419 1.43247632905685 0.104144658896593 0.393480403846662 GO:0005342 organic acid transmembrane transporter activity 12/787 189/18639 0.0634920634920635 1.50372118351788 0.104714401630912 0.394099550324092 GO:0008514 organic anion transmembrane transporter activity 16/787 269/18639 0.0594795539033457 1.40869047675281 0.106610202980414 0.39968535557522 GO:0098531 ligand-modulated transcription factor activity 5/787 60/18639 0.0833333333333333 1.97363405336722 0.108640908305084 0.405732007554756 GO:0008201 heparin binding 11/787 172/18639 0.063953488372093 1.51464938979345 0.112502047095392 0.416040407315479 GO:0046625 sphingolipid binding 3/787 28/18639 0.107142857142857 2.53752949718642 0.112686536687921 0.416040407315479 GO:0046875 ephrin receptor binding 3/787 28/18639 0.107142857142857 2.53752949718642 0.112686536687921 0.416040407315479 GO:0003774 cytoskeletal motor activity 10/787 153/18639 0.065359477124183 1.54794827715076 0.113679583769439 0.418116953939868 GO:0034236 protein kinase A catalytic subunit binding 2/787 14/18639 0.142857142857143 3.38337266291523 0.115929434110163 0.420027912391674 GO:0042043 neurexin family protein binding 2/787 14/18639 0.142857142857143 3.38337266291523 0.115929434110163 0.420027912391674 GO:0044548 S100 protein binding 2/787 14/18639 0.142857142857143 3.38337266291523 0.115929434110163 0.420027912391674 GO:0098847 sequence-specific single stranded DNA binding 2/787 14/18639 0.142857142857143 3.38337266291523 0.115929434110163 0.420027912391674 GO:0015179 L-amino acid transmembrane transporter activity 5/787 62/18639 0.0806451612903226 1.90996843874247 0.120464812072927 0.434837667371048 GO:0004629 phospholipase C activity 3/787 29/18639 0.103448275862069 2.45002848004206 0.121953052540761 0.435375185169232 GO:0043236 laminin binding 3/787 29/18639 0.103448275862069 2.45002848004206 0.121953052540761 0.435375185169232 GO:0019208 phosphatase regulator activity 8/787 117/18639 0.0683760683760684 1.61939204378849 0.121958857225573 0.435375185169232 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/787 46/18639 0.0869565217391304 2.05944422960057 0.128312819151272 0.451426606302602 GO:0005523 tropomyosin binding 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0015116 sulfate transmembrane transporter activity 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0031005 filamin binding 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0031386 protein tag activity 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0050780 dopamine receptor binding 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0140161 monocarboxylate:sodium symporter activity 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0141047 molecular tag activity 2/787 15/18639 0.133333333333333 3.15781448538755 0.130174510571296 0.451426606302602 GO:0001540 amyloid-beta binding 6/787 83/18639 0.072289156626506 1.71206809448722 0.138208406997775 0.477581363682702 GO:0015108 chloride transmembrane transporter activity 8/787 121/18639 0.0661157024793388 1.56585842250622 0.139832796030887 0.481481010446779 GO:0005452 solute:inorganic anion antiporter activity 3/787 31/18639 0.0967741935483871 2.29196212649096 0.141270940770107 0.48471407592853 GO:0004860 protein kinase inhibitor activity 6/787 84/18639 0.0714285714285714 1.69168633145761 0.143893358051108 0.48648704662208 GO:0005149 interleukin-1 receptor binding 2/787 16/18639 0.125 2.96045108005083 0.144793775977118 0.48648704662208 GO:0005159 insulin-like growth factor receptor binding 2/787 16/18639 0.125 2.96045108005083 0.144793775977118 0.48648704662208 GO:0015378 sodium:chloride symporter activity 2/787 16/18639 0.125 2.96045108005083 0.144793775977118 0.48648704662208 GO:0055102 lipase inhibitor activity 2/787 16/18639 0.125 2.96045108005083 0.144793775977118 0.48648704662208 GO:0140328 floppase activity 2/787 16/18639 0.125 2.96045108005083 0.144793775977118 0.48648704662208 GO:0008083 growth factor activity 10/787 162/18639 0.0617283950617284 1.46195115064238 0.148201561827286 0.496219712187224 GO:0016763 pentosyltransferase activity 4/787 49/18639 0.0816326530612245 1.93335580738013 0.151470596301812 0.505422505185773 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/787 86/18639 0.0697674418604651 1.65234478886558 0.155576941218796 0.51357007617258 GO:0032934 sterol binding 5/787 68/18639 0.0735294117647059 1.7414418117946 0.159263351753382 0.51357007617258 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0016805 dipeptidase activity 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0019198 transmembrane receptor protein phosphatase activity 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0038191 neuropilin binding 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0051787 misfolded protein binding 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0070492 oligosaccharide binding 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:1990226 histone methyltransferase binding 2/787 17/18639 0.117647058823529 2.78630689887137 0.159730342949659 0.51357007617258 GO:0000149 SNARE binding 7/787 106/18639 0.0660377358490566 1.56401189134761 0.161043744818693 0.51423304569131 GO:0030296 protein tyrosine kinase activator activity 3/787 33/18639 0.0909090909090909 2.15305533094606 0.161525313013233 0.51423304569131 GO:0071889 14-3-3 protein binding 3/787 33/18639 0.0909090909090909 2.15305533094606 0.161525313013233 0.51423304569131 GO:0019888 protein phosphatase regulator activity 7/787 107/18639 0.0654205607476635 1.54939495778361 0.166505962878345 0.528357156715272 GO:0003743 translation initiation factor activity 4/787 51/18639 0.0784313725490196 1.85753793258091 0.167723883682637 0.530488244481566 GO:0015035 protein-disulfide reductase activity 3/787 34/18639 0.0882352941176471 2.08973017415352 0.171962560360708 0.532471592510317 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/787 34/18639 0.0882352941176471 2.08973017415352 0.171962560360708 0.532471592510317 GO:0051427 hormone receptor binding 3/787 34/18639 0.0882352941176471 2.08973017415352 0.171962560360708 0.532471592510317 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/787 89/18639 0.0674157303370786 1.59664777351056 0.173848446012239 0.532471592510317 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/787 89/18639 0.0674157303370786 1.59664777351056 0.173848446012239 0.532471592510317 GO:0003746 translation elongation factor activity 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0004706 JUN kinase kinase kinase activity 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0015373 monoatomic anion:sodium symporter activity 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0017075 syntaxin-1 binding 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0030228 lipoprotein particle receptor activity 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0031690 adrenergic receptor binding 2/787 18/18639 0.111111111111111 2.63151207115629 0.174931450062607 0.532471592510317 GO:0030159 signaling receptor complex adaptor activity 4/787 52/18639 0.0769230769230769 1.82181604926205 0.176072633467135 0.534270397176837 GO:0019210 kinase inhibitor activity 6/787 90/18639 0.0666666666666667 1.57890724269377 0.180127176898342 0.543178536547486 GO:0140793 histone H2AXY142 phosphatase activity 6/787 90/18639 0.0666666666666667 1.57890724269377 0.180127176898342 0.543178536547486 GO:0061631 ubiquitin conjugating enzyme activity 3/787 35/18639 0.0857142857142857 2.03002359774914 0.182584829725962 0.548885045399098 GO:0005544 calcium-dependent phospholipid binding 4/787 53/18639 0.0754716981132075 1.78744216154012 0.184559297221027 0.553108264202524 GO:0030506 ankyrin binding 2/787 19/18639 0.105263157894737 2.49301143583227 0.190348215562651 0.566957415065441 GO:0070003 threonine-type peptidase activity 2/787 19/18639 0.105263157894737 2.49301143583227 0.190348215562651 0.566957415065441 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/787 54/18639 0.0740740740740741 1.75434138077086 0.193176178707048 0.570724006863178 GO:0051287 NAD binding 4/787 54/18639 0.0740740740740741 1.75434138077086 0.193176178707048 0.570724006863178 GO:0005484 SNAP receptor activity 3/787 36/18639 0.0833333333333333 1.97363405336722 0.193376105312035 0.570724006863178 GO:0003713 transcription coactivator activity 14/787 256/18639 0.0546875 1.29519734752224 0.195697134130489 0.575823991638499 GO:0001217 DNA-binding transcription repressor activity 15/787 278/18639 0.0539568345323741 1.27789255253992 0.19904226394049 0.583897396635093 GO:0016004 phospholipase activator activity 2/787 20/18639 0.1 2.36836086404066 0.205935404490842 0.600490323605427 GO:0030742 GTP-dependent protein binding 2/787 20/18639 0.1 2.36836086404066 0.205935404490842 0.600490323605427 GO:0044183 protein folding chaperone 5/787 75/18639 0.0666666666666667 1.57890724269377 0.209936509655649 0.610324403819266 GO:0000146 microfilament motor activity 3/787 38/18639 0.0789473684210526 1.86975857687421 0.21540291997899 0.624346971043581 GO:0019838 growth factor binding 8/787 136/18639 0.0588235294117647 1.39315344943568 0.217135023318956 0.625421045905078 GO:0140789 histone phosphatase activity 8/787 136/18639 0.0588235294117647 1.39315344943568 0.217135023318956 0.625421045905078 GO:0046982 protein heterodimerization activity 19/787 369/18639 0.0514905149051491 1.21948120370657 0.217705781169842 0.625421045905078 GO:0016504 peptidase activator activity 4/787 57/18639 0.0701754385964912 1.66200762388818 0.219730735642242 0.627473246258715 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/787 21/18639 0.0952380952380952 2.25558177527682 0.221651208513635 0.627473246258715 GO:0005123 death receptor binding 2/787 21/18639 0.0952380952380952 2.25558177527682 0.221651208513635 0.627473246258715 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/787 21/18639 0.0952380952380952 2.25558177527682 0.221651208513635 0.627473246258715 GO:0140312 cargo adaptor activity 2/787 21/18639 0.0952380952380952 2.25558177527682 0.221651208513635 0.627473246258715 GO:0016922 nuclear receptor binding 8/787 137/18639 0.0583941605839416 1.38298444615513 0.222790383983649 0.628864717581755 GO:0004725 protein tyrosine phosphatase activity 6/787 98/18639 0.0612244897959184 1.4500168555351 0.233324806136122 0.648996251946465 GO:0042626 ATPase-coupled transmembrane transporter activity 6/787 98/18639 0.0612244897959184 1.4500168555351 0.233324806136122 0.648996251946465 GO:0015377 chloride:monoatomic cation symporter activity 2/787 22/18639 0.0909090909090909 2.15305533094606 0.237457037807618 0.648996251946465 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/787 22/18639 0.0909090909090909 2.15305533094606 0.237457037807618 0.648996251946465 GO:0031683 G-protein beta/gamma-subunit complex binding 2/787 22/18639 0.0909090909090909 2.15305533094606 0.237457037807618 0.648996251946465 GO:0015036 disulfide oxidoreductase activity 3/787 40/18639 0.075 1.7762706480305 0.237920625475994 0.648996251946465 GO:0015144 carbohydrate transmembrane transporter activity 3/787 40/18639 0.075 1.7762706480305 0.237920625475994 0.648996251946465 GO:0030331 nuclear estrogen receptor binding 3/787 40/18639 0.075 1.7762706480305 0.237920625475994 0.648996251946465 GO:0140662 ATP-dependent protein folding chaperone 3/787 40/18639 0.075 1.7762706480305 0.237920625475994 0.648996251946465 GO:0004879 nuclear receptor activity 4/787 59/18639 0.0677966101694915 1.60566838240045 0.23794301307203 0.648996251946465 GO:0015459 potassium channel regulator activity 4/787 59/18639 0.0677966101694915 1.60566838240045 0.23794301307203 0.648996251946465 GO:0036002 pre-mRNA binding 4/787 59/18639 0.0677966101694915 1.60566838240045 0.23794301307203 0.648996251946465 GO:0000049 tRNA binding 5/787 80/18639 0.0625 1.48022554002541 0.248900655116627 0.672489916173276 GO:0001530 lipopolysaccharide binding 3/787 41/18639 0.0731707317073171 1.73294697368829 0.249326848426755 0.672489916173276 GO:0001727 lipid kinase activity 3/787 41/18639 0.0731707317073171 1.73294697368829 0.249326848426755 0.672489916173276 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/787 41/18639 0.0731707317073171 1.73294697368829 0.249326848426755 0.672489916173276 GO:0004602 glutathione peroxidase activity 2/787 23/18639 0.0869565217391304 2.05944422960057 0.253317324374547 0.673893484842973 GO:0005158 insulin receptor binding 2/787 23/18639 0.0869565217391304 2.05944422960057 0.253317324374547 0.673893484842973 GO:0005283 amino acid:sodium symporter activity 2/787 23/18639 0.0869565217391304 2.05944422960057 0.253317324374547 0.673893484842973 GO:0099186 structural constituent of postsynapse 2/787 23/18639 0.0869565217391304 2.05944422960057 0.253317324374547 0.673893484842973 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/787 23/18639 0.0869565217391304 2.05944422960057 0.253317324374547 0.673893484842973 GO:0015026 coreceptor activity 4/787 61/18639 0.0655737704918033 1.55302351740371 0.256491114597742 0.677878450526043 GO:0019905 syntaxin binding 4/787 61/18639 0.0655737704918033 1.55302351740371 0.256491114597742 0.677878450526043 GO:0030971 receptor tyrosine kinase binding 5/787 81/18639 0.0617283950617284 1.46195115064238 0.256909649632939 0.677878450526043 GO:0051879 Hsp90 protein binding 3/787 42/18639 0.0714285714285714 1.69168633145761 0.260812517800413 0.68631153058049 GO:0031406 carboxylic acid binding 10/787 187/18639 0.053475935828877 1.26650313585062 0.266843252799569 0.693348953434247 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0005315 phosphate transmembrane transporter activity 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0005540 hyaluronic acid binding 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0015149 hexose transmembrane transporter activity 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0050699 WW domain binding 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0055056 D-glucose transmembrane transporter activity 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0060229 lipase activator activity 2/787 24/18639 0.0833333333333333 1.97363405336722 0.269199336194347 0.693348953434247 GO:0003712 transcription coregulator activity 24/787 495/18639 0.0484848484848485 1.14829617650456 0.270852493449625 0.695761299311075 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/787 43/18639 0.0697674418604651 1.65234478886558 0.272364055144103 0.695961835644536 GO:0048156 tau protein binding 3/787 43/18639 0.0697674418604651 1.65234478886558 0.272364055144103 0.695961835644536 GO:0005254 chloride channel activity 5/787 83/18639 0.0602409638554217 1.42672341207269 0.273106043501169 0.696026163358623 GO:0043177 organic acid binding 10/787 189/18639 0.0529100529100529 1.2531009862649 0.277468114382459 0.705291987082115 GO:0051117 ATPase binding 5/787 84/18639 0.0595238095238095 1.40973860954801 0.281284061567629 0.707943438888408 GO:0001223 transcription coactivator binding 3/787 44/18639 0.0681818181818182 1.61479149820954 0.283968317372185 0.707943438888408 GO:0030547 signaling receptor inhibitor activity 3/787 44/18639 0.0681818181818182 1.61479149820954 0.283968317372185 0.707943438888408 GO:0004709 MAP kinase kinase kinase activity 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0005537 D-mannose binding 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0015662 P-type ion transporter activity 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0120020 cholesterol transfer activity 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0140358 P-type transmembrane transporter activity 2/787 25/18639 0.08 1.89468869123253 0.285073001653314 0.707943438888408 GO:0019209 kinase activator activity 8/787 148/18639 0.0540540540540541 1.2801950616436 0.288140328023578 0.713735353344118 GO:0008509 monoatomic anion transmembrane transporter activity 8/787 149/18639 0.0536912751677852 1.27160314847821 0.294318841537184 0.726683145558178 GO:0046915 transition metal ion transmembrane transporter activity 3/787 45/18639 0.0666666666666667 1.57890724269377 0.295612608131288 0.726683145558178 GO:0140303 intramembrane lipid transporter activity 3/787 45/18639 0.0666666666666667 1.57890724269377 0.295612608131288 0.726683145558178 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/787 26/18639 0.0769230769230769 1.82181604926205 0.300910743712825 0.730460830362884 GO:0008198 ferrous iron binding 2/787 26/18639 0.0769230769230769 1.82181604926205 0.300910743712825 0.730460830362884 GO:0015145 monosaccharide transmembrane transporter activity 2/787 26/18639 0.0769230769230769 1.82181604926205 0.300910743712825 0.730460830362884 GO:0034237 protein kinase A regulatory subunit binding 2/787 26/18639 0.0769230769230769 1.82181604926205 0.300910743712825 0.730460830362884 GO:0070412 R-SMAD binding 2/787 26/18639 0.0769230769230769 1.82181604926205 0.300910743712825 0.730460830362884 GO:0030276 clathrin binding 3/787 46/18639 0.0652173913043478 1.54458317220043 0.307284686432219 0.744073392832131 GO:0005044 scavenger receptor activity 2/787 27/18639 0.0740740740740741 1.75434138077086 0.316687323310656 0.757672423191615 GO:0008266 poly(U) RNA binding 2/787 27/18639 0.0740740740740741 1.75434138077086 0.316687323310656 0.757672423191615 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/787 27/18639 0.0740740740740741 1.75434138077086 0.316687323310656 0.757672423191615 GO:0140359 ABC-type transporter activity 3/787 47/18639 0.0638297872340425 1.51171970045149 0.318972772800524 0.757672423191615 GO:0030145 manganese ion binding 4/787 68/18639 0.0588235294117647 1.39315344943568 0.323199756748376 0.757672423191615 GO:1902936 phosphatidylinositol bisphosphate binding 6/787 111/18639 0.0540540540540541 1.2801950616436 0.327861731421936 0.757672423191615 GO:0016866 intramolecular transferase activity 2/787 28/18639 0.0714285714285714 1.69168633145761 0.332379691512406 0.757672423191615 GO:0046966 nuclear thyroid hormone receptor binding 2/787 28/18639 0.0714285714285714 1.69168633145761 0.332379691512406 0.757672423191615 GO:0051019 mitogen-activated protein kinase binding 2/787 28/18639 0.0714285714285714 1.69168633145761 0.332379691512406 0.757672423191615 GO:0051119 sugar transmembrane transporter activity 2/787 28/18639 0.0714285714285714 1.69168633145761 0.332379691512406 0.757672423191615 GO:0072341 modified amino acid binding 5/787 91/18639 0.0549450549450549 1.30129717804432 0.339591310142375 0.757672423191615 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 13/787 268/18639 0.0485074626865672 1.14883176240778 0.344014719308636 0.757672423191615 GO:0005416 amino acid:monoatomic cation symporter activity 2/787 29/18639 0.0689655172413793 1.63335232002804 0.347966849954749 0.757672423191615 GO:0106222 lncRNA binding 2/787 29/18639 0.0689655172413793 1.63335232002804 0.347966849954749 0.757672423191615 GO:0043178 alcohol binding 5/787 92/18639 0.0543478260869565 1.28715264350036 0.348018972148046 0.757672423191615 GO:0001094 TFIID-class transcription factor complex binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0003796 lysozyme activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0004090 carbonyl reductase (NADPH) activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0004382 GDP phosphatase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0004935 adrenergic receptor activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0005528 FK506 binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0008140 cAMP response element binding protein binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0008239 dipeptidyl-peptidase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0016868 intramolecular phosphotransferase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0019531 oxalate transmembrane transporter activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0031996 thioesterase binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0032052 bile acid binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0035256 G protein-coupled glutamate receptor binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0035374 chondroitin sulfate binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0042166 acetylcholine binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0042975 peroxisome proliferator activated receptor binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0045322 unmethylated CpG binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0050308 sugar-phosphatase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0051864 histone H3K36 demethylase activity 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0098505 G-rich strand telomeric DNA binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0099122 RNA polymerase II C-terminal domain binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:1905394 retromer complex binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:1990763 arrestin family protein binding 1/787 10/18639 0.1 2.36836086404066 0.35047412164319 0.757672423191615 GO:0003714 transcription corepressor activity 10/787 204/18639 0.0490196078431373 1.16096120786307 0.360380137612631 0.757672423191615 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/787 30/18639 0.0666666666666667 1.57890724269377 0.363429719145293 0.757672423191615 GO:0070566 adenylyltransferase activity 2/787 30/18639 0.0666666666666667 1.57890724269377 0.363429719145293 0.757672423191615 GO:0098918 structural constituent of synapse 2/787 30/18639 0.0666666666666667 1.57890724269377 0.363429719145293 0.757672423191615 GO:0009055 electron transfer activity 6/787 116/18639 0.0517241379310345 1.22501424002103 0.365631499511261 0.757672423191615 GO:0043539 protein serine/threonine kinase activator activity 4/787 73/18639 0.0547945205479452 1.29773198029625 0.371585573558836 0.757672423191615 GO:0030295 protein kinase activator activity 7/787 139/18639 0.0503597122302158 1.19269971570393 0.372081271303947 0.757672423191615 GO:0140767 enzyme-substrate adaptor activity 7/787 139/18639 0.0503597122302158 1.19269971570393 0.372081271303947 0.757672423191615 GO:1990782 protein tyrosine kinase binding 6/787 117/18639 0.0512820512820513 1.21454403284136 0.373219814024315 0.757672423191615 GO:0004867 serine-type endopeptidase inhibitor activity 5/787 95/18639 0.0526315789473684 1.24650571791614 0.37335502930921 0.757672423191615 GO:0005516 calmodulin binding 10/787 207/18639 0.0483091787439614 1.14413568311143 0.377415537025662 0.757672423191615 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0001851 complement component C3b binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0002162 dystroglycan binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0005225 volume-sensitive anion channel activity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0008503 benzodiazepine receptor activity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0015217 ADP transmembrane transporter activity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0019203 carbohydrate phosphatase activity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0019215 intermediate filament binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0032050 clathrin heavy chain binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0034511 U3 snoRNA binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0043522 leucine zipper domain binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0050786 RAGE receptor binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0070697 activin receptor binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0070990 snRNP binding 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:0097493 structural molecule activity conferring elasticity 1/787 11/18639 0.0909090909090909 2.15305533094606 0.377913966308325 0.757672423191615 GO:1901681 sulfur compound binding 13/787 275/18639 0.0472727272727273 1.11958877209195 0.378330830838877 0.757672423191615 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/787 31/18639 0.0645161290322581 1.52797475099397 0.378751014205651 0.757672423191615 GO:0016411 acylglycerol O-acyltransferase activity 2/787 31/18639 0.0645161290322581 1.52797475099397 0.378751014205651 0.757672423191615 GO:0070273 phosphatidylinositol-4-phosphate binding 2/787 31/18639 0.0645161290322581 1.52797475099397 0.378751014205651 0.757672423191615 GO:0016860 intramolecular oxidoreductase activity 3/787 53/18639 0.0566037735849057 1.34058162115509 0.388836541225084 0.757672423191615 GO:0140296 general transcription initiation factor binding 3/787 53/18639 0.0566037735849057 1.34058162115509 0.388836541225084 0.757672423191615 GO:0031369 translation initiation factor binding 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0042910 xenobiotic transmembrane transporter activity 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0070717 poly-purine tract binding 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0071813 lipoprotein particle binding 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0071814 protein-lipid complex binding 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0120015 sterol transfer activity 2/787 32/18639 0.0625 1.48022554002541 0.393915127665244 0.757672423191615 GO:0017069 snRNA binding 3/787 54/18639 0.0555555555555556 1.31575603557814 0.40034597431438 0.757672423191615 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/787 54/18639 0.0555555555555556 1.31575603557814 0.40034597431438 0.757672423191615 GO:0051082 unfolded protein binding 6/787 121/18639 0.0495867768595041 1.17439381687967 0.403589528305015 0.757672423191615 GO:0003720 telomerase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0003995 acyl-CoA dehydrogenase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0005025 transforming growth factor beta receptor activity, type I 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0005026 transforming growth factor beta receptor activity, type II 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0005095 GTPase inhibitor activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0005527 macrolide binding 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0008603 cAMP-dependent protein kinase regulator activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0015166 polyol transmembrane transporter activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0015269 calcium-activated potassium channel activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0016208 AMP binding 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0016361 activin receptor activity, type I 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0016362 activin receptor activity, type II 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0016423 tRNA (guanine) methyltransferase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0017002 activin receptor activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0031543 peptidyl-proline dioxygenase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0043047 single-stranded telomeric DNA binding 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0045295 gamma-catenin binding 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0140900 chloride:bicarbonate antiporter activity 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:1990459 transferrin receptor binding 1/787 12/18639 0.0833333333333333 1.97363405336722 0.40419599918976 0.757672423191615 GO:0019239 deaminase activity 2/787 33/18639 0.0606060606060606 1.4353702206307 0.408908018933116 0.765028297464461 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/787 122/18639 0.0491803278688525 1.16476763805278 0.411171992685465 0.767469982877349 GO:0008374 O-acyltransferase activity 3/787 55/18639 0.0545454545454545 1.29183319856763 0.41179388370659 0.767469982877349 GO:0005201 extracellular matrix structural constituent 8/787 168/18639 0.0476190476190476 1.12779088763841 0.415532378263509 0.767803522442223 GO:0001216 DNA-binding transcription activator activity 22/787 491/18639 0.044806517311609 1.06118002054775 0.418163334058133 0.767803522442223 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/787 34/18639 0.0588235294117647 1.39315344943568 0.423717110093891 0.767803522442223 GO:0019825 oxygen binding 2/787 34/18639 0.0588235294117647 1.39315344943568 0.423717110093891 0.767803522442223 GO:0003730 mRNA 3'-UTR binding 12/787 262/18639 0.0458015267175573 1.08474543391175 0.428354299592916 0.767803522442223 GO:0033293 monocarboxylic acid binding 4/787 79/18639 0.0506329113924051 1.19917005774211 0.429241629276047 0.767803522442223 GO:0003964 RNA-directed DNA polymerase activity 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0008035 high-density lipoprotein particle binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0030955 potassium ion binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0031994 insulin-like growth factor I binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0039706 co-receptor binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0043560 insulin receptor substrate binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0045159 myosin II binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0061459 L-arginine transmembrane transporter activity 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0070123 transforming growth factor beta receptor activity, type III 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0071837 HMG box domain binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0089720 caspase binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0140333 glycerophospholipid flippase activity 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:1901338 catecholamine binding 1/787 13/18639 0.0769230769230769 1.82181604926205 0.429369014094878 0.767803522442223 GO:0008238 exopeptidase activity 5/787 102/18639 0.0490196078431373 1.16096120786307 0.432278363676741 0.771585093989183 GO:0004601 peroxidase activity 3/787 57/18639 0.0526315789473684 1.24650571791614 0.434474940720127 0.774082876035308 GO:0000175 3'-5'-RNA exonuclease activity 2/787 35/18639 0.0571428571428571 1.35334906516609 0.438331187691948 0.776594070965243 GO:0005343 organic acid:sodium symporter activity 2/787 35/18639 0.0571428571428571 1.35334906516609 0.438331187691948 0.776594070965243 GO:0005253 monoatomic anion channel activity 5/787 103/18639 0.0485436893203883 1.14968973982556 0.440620119915271 0.776594070965243 GO:0033192 calmodulin-dependent protein phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0140791 histone H2AXS140 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:1990439 MAP kinase serine/threonine phosphatase activity 4/787 81/18639 0.0493827160493827 1.16956092051391 0.448178641825459 0.776594070965243 GO:0004033 aldo-keto reductase (NADPH) activity 2/787 36/18639 0.0555555555555556 1.31575603557814 0.452740310184884 0.776594070965243 GO:0005347 ATP transmembrane transporter activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0005545 1-phosphatidylinositol binding 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0008392 arachidonate epoxygenase activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0008559 ABC-type xenobiotic transporter activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0061665 SUMO ligase activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0061783 peptidoglycan muralytic activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0071933 Arp2/3 complex binding 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0098821 BMP receptor activity 1/787 14/18639 0.0714285714285714 1.69168633145761 0.45347975101678 0.776594070965243 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3/787 59/18639 0.0508474576271186 1.20425128680034 0.456823580361559 0.779480403573201 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4/787 82/18639 0.0487804878048781 1.15529798245886 0.457573460387976 0.779480403573201 GO:0033549 MAP kinase phosphatase activity 4/787 82/18639 0.0487804878048781 1.15529798245886 0.457573460387976 0.779480403573201 GO:0004721 phosphoprotein phosphatase activity 8/787 175/18639 0.0457142857142857 1.08267925213287 0.460532047889423 0.783146442207758 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/787 83/18639 0.0481927710843374 1.14137872965815 0.466913582761991 0.788334524676888 GO:0022829 wide pore channel activity 2/787 37/18639 0.0540540540540541 1.2801950616436 0.46693572076359 0.788334524676888 GO:0042393 histone binding 11/787 247/18639 0.0445344129554656 1.0547356074675 0.471958821904614 0.788334524676888 GO:0017018 myosin phosphatase activity 4/787 84/18639 0.0476190476190476 1.12779088763841 0.47619505882171 0.788334524676888 GO:0000774 adenyl-nucleotide exchange factor activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0004559 alpha-mannosidase activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0005041 low-density lipoprotein particle receptor activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0015250 water channel activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0050700 CARD domain binding 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0061578 K63-linked deubiquitinase activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0140776 protein-containing complex destabilizing activity 1/787 15/18639 0.0666666666666667 1.57890724269377 0.476572982477171 0.788334524676888 GO:0005319 lipid transporter activity 8/787 178/18639 0.0449438202247191 1.06443184900704 0.479629996403826 0.790124165921027 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 21/787 484/18639 0.0433884297520661 1.02759458976971 0.4808793939212 0.790124165921027 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/787 38/18639 0.0526315789473684 1.24650571791614 0.480909765251624 0.790124165921027 GO:0042162 telomeric DNA binding 2/787 38/18639 0.0526315789473684 1.24650571791614 0.480909765251624 0.790124165921027 GO:0005496 steroid binding 5/787 108/18639 0.0462962962962963 1.09646336298179 0.481831165573465 0.790300780019991 GO:0016209 antioxidant activity 4/787 86/18639 0.0465116279069767 1.10156319257705 0.494567173786764 0.792519705323683 GO:0050660 flavin adenine dinucleotide binding 4/787 86/18639 0.0465116279069767 1.10156319257705 0.494567173786764 0.792519705323683 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0004708 MAP kinase kinase activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0005024 transforming growth factor beta receptor activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0008142 oxysterol binding 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0008296 3'-5'-DNA exonuclease activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0008391 arachidonate monooxygenase activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0015562 efflux transmembrane transporter activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0015923 mannosidase activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0016722 oxidoreductase activity, acting on metal ions 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0017070 U6 snRNA binding 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0022858 alanine transmembrane transporter activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0030275 LRR domain binding 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0043023 ribosomal large subunit binding 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0140327 flippase activity 1/787 16/18639 0.0625 1.48022554002541 0.498691596243842 0.792519705323683 GO:0015297 antiporter activity 6/787 135/18639 0.0444444444444444 1.05260482846252 0.507984625176012 0.8023273424302 GO:0004177 aminopeptidase activity 2/787 40/18639 0.05 1.18418043202033 0.508168193197295 0.8023273424302 GO:0004532 RNA exonuclease activity 2/787 40/18639 0.05 1.18418043202033 0.508168193197295 0.8023273424302 GO:0071949 FAD binding 2/787 40/18639 0.05 1.18418043202033 0.508168193197295 0.8023273424302 GO:0004536 DNA nuclease activity 3/787 64/18639 0.046875 1.11016915501906 0.510931027221889 0.805379914663075 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/787 88/18639 0.0454545454545455 1.07652766547303 0.512661786742452 0.806242495497826 GO:0016779 nucleotidyltransferase activity 6/787 136/18639 0.0441176470588235 1.04486508707676 0.515216669618004 0.806242495497826 GO:0005092 GDP-dissociation inhibitor activity 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0008429 phosphatidylethanolamine binding 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0017110 nucleoside diphosphate phosphatase activity 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0030169 low-density lipoprotein particle binding 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0031489 myosin V binding 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0036041 long-chain fatty acid binding 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0070403 NAD+ binding 1/787 17/18639 0.0588235294117647 1.39315344943568 0.519876674574728 0.806242495497826 GO:0019843 rRNA binding 3/787 65/18639 0.0461538461538462 1.09308962955723 0.521410484657873 0.806242495497826 GO:0008227 G protein-coupled amine receptor activity 2/787 41/18639 0.0487804878048781 1.15529798245886 0.521442108313733 0.806242495497826 GO:0008235 metalloexopeptidase activity 3/787 66/18639 0.0454545454545455 1.07652766547303 0.531766247882195 0.816982415265375 GO:0004520 DNA endonuclease activity 2/787 42/18639 0.0476190476190476 1.12779088763841 0.534473587839399 0.816982415265375 GO:0019894 kinesin binding 2/787 42/18639 0.0476190476190476 1.12779088763841 0.534473587839399 0.816982415265375 GO:0031492 nucleosomal DNA binding 2/787 42/18639 0.0476190476190476 1.12779088763841 0.534473587839399 0.816982415265375 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/787 91/18639 0.043956043956044 1.04103774243546 0.539228953668795 0.816982415265375 GO:0000400 four-way junction DNA binding 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0000900 mRNA regulatory element binding translation repressor activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0005372 water transmembrane transporter activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0008525 phosphatidylcholine transporter activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0015172 acidic amino acid transmembrane transporter activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0017128 phospholipid scramblase activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0034185 apolipoprotein binding 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0035615 clathrin adaptor activity 1/787 18/18639 0.0555555555555556 1.31575603557814 0.540167570134265 0.816982415265375 GO:0052689 carboxylic ester hydrolase activity 4/787 92/18639 0.0434782608695652 1.02972211480029 0.547920316465193 0.827419327041527 GO:0005548 phospholipid transporter activity 3/787 68/18639 0.0441176470588235 1.04486508707676 0.552093066956458 0.82986713676163 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0005229 intracellularly calcium-gated chloride channel activity 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0005520 insulin-like growth factor binding 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0008301 DNA binding, bending 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0015245 fatty acid transmembrane transporter activity 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0031420 alkali metal ion binding 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0043395 heparan sulfate proteoglycan binding 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0097001 ceramide binding 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0141147 intracellularly calcium-gated channel activity 1/787 19/18639 0.0526315789473684 1.24650571791614 0.559601978721576 0.82986713676163 GO:0001046 core promoter sequence-specific DNA binding 2/787 44/18639 0.0454545454545455 1.07652766547303 0.559797090194508 0.82986713676163 GO:0016247 channel regulator activity 7/787 168/18639 0.0416666666666667 0.986817026683609 0.568318632798702 0.841215537267591 GO:0001614 purinergic nucleotide receptor activity 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0001972 retinoic acid binding 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0015464 acetylcholine receptor activity 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0016502 nucleotide receptor activity 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0016505 peptidase activator activity involved in apoptotic process 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0031418 L-ascorbic acid binding 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0061608 nuclear import signal receptor activity 1/787 20/18639 0.05 1.18418043202033 0.578216008944247 0.846829177503565 GO:0141108 transporter regulator activity 7/787 170/18639 0.0411764705882353 0.975207414604978 0.580920704857581 0.849509042796252 GO:0003697 single-stranded DNA binding 5/787 121/18639 0.0413223140495868 0.978661514066389 0.583144611933114 0.851478824341435 GO:0004180 carboxypeptidase activity 2/787 46/18639 0.0434782608695652 1.02972211480029 0.584121106618066 0.851624015805019 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/787 122/18639 0.040983606557377 0.97063969837732 0.59049386916592 0.853626793135354 GO:0005518 collagen binding 3/787 72/18639 0.0416666666666667 0.986817026683609 0.591129334653988 0.853626793135354 GO:0016887 ATP hydrolysis activity 17/787 417/18639 0.0407673860911271 0.96551881747461 0.594366995681903 0.853626793135354 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0001846 opsonin binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0015125 bile acid transmembrane transporter activity 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0015174 basic amino acid transmembrane transporter activity 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0035613 RNA stem-loop binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0036122 BMP binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0051010 microtubule plus-end binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0051428 peptide hormone receptor binding 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0061891 calcium ion sensor activity 1/787 21/18639 0.0476190476190476 1.12779088763841 0.596044248965777 0.853626793135354 GO:0032266 phosphatidylinositol-3-phosphate binding 2/787 48/18639 0.0416666666666667 0.986817026683609 0.607437647611285 0.859477913754607 GO:0140693 molecular condensate scaffold activity 2/787 48/18639 0.0416666666666667 0.986817026683609 0.607437647611285 0.859477913754607 GO:0031491 nucleosome binding 3/787 74/18639 0.0405405405405405 0.9601462962327 0.609803900467308 0.859477913754607 GO:0005243 gap junction channel activity 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0008093 cytoskeletal anchor activity 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0008649 rRNA methyltransferase activity 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0061133 endopeptidase activator activity 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0070034 telomerase RNA binding 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0140784 metal ion sensor activity 1/787 22/18639 0.0454545454545455 1.07652766547303 0.613119830449499 0.859477913754607 GO:0043130 ubiquitin binding 4/787 100/18639 0.04 0.947344345616264 0.614173436230817 0.859477913754607 GO:0005004 GPI-linked ephrin receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0005008 hepatocyte growth factor receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0005009 insulin receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0005011 macrophage colony-stimulating factor receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0005020 stem cell factor receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0008288 boss receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0035254 glutamate receptor binding 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0036332 placental growth factor receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0038062 protein tyrosine kinase collagen receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0060175 brain-derived neurotrophic factor receptor activity 2/787 49/18639 0.0408163265306122 0.966677903690066 0.618717880241473 0.859477913754607 GO:0004519 endonuclease activity 5/787 127/18639 0.0393700787401575 0.932425537023882 0.626138939352451 0.860074109357542 GO:0000295 adenine nucleotide transmembrane transporter activity 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0005212 structural constituent of eye lens 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0043274 phospholipase binding 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0070577 lysine-acetylated histone binding 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0140102 catalytic activity, acting on a rRNA 1/787 23/18639 0.0434782608695652 1.02972211480029 0.629474489816542 0.860074109357542 GO:0005006 epidermal growth factor receptor activity 2/787 50/18639 0.04 0.947344345616264 0.629746863741836 0.860074109357542 GO:0005007 fibroblast growth factor receptor activity 2/787 50/18639 0.04 0.947344345616264 0.629746863741836 0.860074109357542 GO:0005017 platelet-derived growth factor receptor activity 2/787 50/18639 0.04 0.947344345616264 0.629746863741836 0.860074109357542 GO:0005019 platelet-derived growth factor beta-receptor activity 2/787 50/18639 0.04 0.947344345616264 0.629746863741836 0.860074109357542 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 5/787 128/18639 0.0390625 0.925140962515883 0.633039775401296 0.860074109357542 GO:0004722 protein serine/threonine phosphatase activity 4/787 103/18639 0.0388349514563107 0.919751791860451 0.637406020384347 0.860074109357542 GO:0005010 insulin-like growth factor receptor activity 2/787 51/18639 0.0392156862745098 0.928768966290455 0.640525677536722 0.860074109357542 GO:0005021 vascular endothelial growth factor receptor activity 2/787 51/18639 0.0392156862745098 0.928768966290455 0.640525677536722 0.860074109357542 GO:0005030 neurotrophin receptor activity 2/787 51/18639 0.0392156862745098 0.928768966290455 0.640525677536722 0.860074109357542 GO:0016830 carbon-carbon lyase activity 2/787 51/18639 0.0392156862745098 0.928768966290455 0.640525677536722 0.860074109357542 GO:0004622 lysophospholipase activity 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0015295 solute:proton symporter activity 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0030215 semaphorin receptor binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0035035 histone acetyltransferase binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0050431 transforming growth factor beta binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0070840 dynein complex binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0140033 acetylation-dependent protein binding 1/787 24/18639 0.0416666666666667 0.986817026683609 0.645138626930551 0.860074109357542 GO:0019199 transmembrane receptor protein kinase activity 3/787 78/18639 0.0384615384615385 0.910908024631023 0.645408542244198 0.860074109357542 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/787 130/18639 0.0384615384615385 0.910908024631023 0.646605664089604 0.860074109357542 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/787 130/18639 0.0384615384615385 0.910908024631023 0.646605664089604 0.860074109357542 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/787 52/18639 0.0384615384615385 0.910908024631023 0.651055757503913 0.860643599246592 GO:0016835 carbon-oxygen lyase activity 3/787 79/18639 0.0379746835443038 0.89937754330658 0.653941446703467 0.860643599246592 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 5/787 132/18639 0.0378787878787879 0.89710638789419 0.65985212642225 0.860643599246592 GO:0001848 complement binding 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0005251 delayed rectifier potassium channel activity 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0017056 structural constituent of nuclear pore 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0019707 protein-cysteine S-acyltransferase activity 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/787 25/18639 0.04 0.947344345616264 0.660141361317102 0.860643599246592 GO:0004518 nuclease activity 8/787 209/18639 0.0382775119617225 0.906549613029918 0.661217956568369 0.860643599246592 GO:0004864 protein phosphatase inhibitor activity 2/787 53/18639 0.0377358490566038 0.893721080770061 0.661338864024652 0.860643599246592 GO:0005003 ephrin receptor activity 2/787 53/18639 0.0377358490566038 0.893721080770061 0.661338864024652 0.860643599246592 GO:0005005 transmembrane-ephrin receptor activity 2/787 53/18639 0.0377358490566038 0.893721080770061 0.661338864024652 0.860643599246592 GO:0038064 collagen receptor activity 2/787 53/18639 0.0377358490566038 0.893721080770061 0.661338864024652 0.860643599246592 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/787 53/18639 0.0377358490566038 0.893721080770061 0.661338864024652 0.860643599246592 GO:0015631 tubulin binding 15/787 385/18639 0.038961038961039 0.922737998976881 0.662404719139797 0.860643599246592 GO:0008237 metallopeptidase activity 7/787 184/18639 0.0380434782608696 0.901006850450251 0.663680620038488 0.860643599246592 GO:0015291 secondary active transmembrane transporter activity 11/787 287/18639 0.0383275261324042 0.907734129074818 0.671423056151587 0.860643599246592 GO:0099106 ion channel regulator activity 6/787 160/18639 0.0375 0.888135324015248 0.673219873121539 0.860643599246592 GO:0004529 DNA exonuclease activity 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0005112 Notch binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0005227 calcium-activated cation channel activity 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0008143 poly(A) binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0015216 purine nucleotide transmembrane transporter activity 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0030247 polysaccharide binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0050681 nuclear androgen receptor binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0050750 low-density lipoprotein particle receptor binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0051139 metal cation:proton antiporter activity 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0070006 metalloaminopeptidase activity 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0097602 cullin family protein binding 1/787 26/18639 0.0384615384615385 0.910908024631023 0.674510586021273 0.860643599246592 GO:0004620 phospholipase activity 4/787 109/18639 0.036697247706422 0.869123252858958 0.681067937276879 0.867870035558857 GO:0030165 PDZ domain binding 3/787 83/18639 0.036144578313253 0.856034047243612 0.686590967665217 0.872471412069948 GO:0004222 metalloendopeptidase activity 4/787 110/18639 0.0363636363636364 0.861222132378422 0.687975067603854 0.872471412069948 GO:0015252 proton channel activity 1/787 27/18639 0.037037037037037 0.87717069038543 0.688273019202451 0.872471412069948 GO:0035255 ionotropic glutamate receptor binding 1/787 27/18639 0.037037037037037 0.87717069038543 0.688273019202451 0.872471412069948 GO:0019212 phosphatase inhibitor activity 2/787 56/18639 0.0357142857142857 0.845843165728807 0.690728199987722 0.874442088902319 GO:0019789 SUMO transferase activity 1/787 28/18639 0.0357142857142857 0.845843165728807 0.701454253561342 0.88273430575722 GO:0045499 chemorepellent activity 1/787 28/18639 0.0357142857142857 0.845843165728807 0.701454253561342 0.88273430575722 GO:0051959 dynein light intermediate chain binding 1/787 28/18639 0.0357142857142857 0.845843165728807 0.701454253561342 0.88273430575722 GO:0141052 histone H3 demethylase activity 1/787 28/18639 0.0357142857142857 0.845843165728807 0.701454253561342 0.88273430575722 GO:0016755 aminoacyltransferase activity 19/787 496/18639 0.0383064516129032 0.907235008402673 0.701823773475359 0.88273430575722 GO:0015399 primary active transmembrane transporter activity 6/787 166/18639 0.036144578313253 0.856034047243612 0.707111995457944 0.885240623685056 GO:0061659 ubiquitin-like protein ligase activity 14/787 372/18639 0.0376344086021505 0.891318604746485 0.708365877084278 0.885240623685056 GO:0008408 3'-5' exonuclease activity 2/787 58/18639 0.0344827586206897 0.816676160014021 0.709130516050934 0.885240623685056 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/787 29/18639 0.0344827586206897 0.816676160014021 0.714078803690148 0.885240623685056 GO:0016417 S-acyltransferase activity 1/787 29/18639 0.0344827586206897 0.816676160014021 0.714078803690148 0.885240623685056 GO:0035250 UDP-galactosyltransferase activity 1/787 29/18639 0.0344827586206897 0.816676160014021 0.714078803690148 0.885240623685056 GO:0097472 cyclin-dependent protein kinase activity 1/787 29/18639 0.0344827586206897 0.816676160014021 0.714078803690148 0.885240623685056 GO:0008081 phosphoric diester hydrolase activity 3/787 87/18639 0.0344827586206897 0.816676160014021 0.716879962807752 0.885240623685056 GO:0070063 RNA polymerase binding 2/787 59/18639 0.0338983050847458 0.802834191200224 0.717983390987403 0.885240623685056 GO:0070888 E-box binding 2/787 59/18639 0.0338983050847458 0.802834191200224 0.717983390987403 0.885240623685056 GO:0033218 amide binding 9/787 247/18639 0.0364372469635627 0.862965497018864 0.720420229420481 0.885240623685056 GO:0001965 G-protein alpha-subunit binding 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0015215 nucleotide transmembrane transporter activity 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0016769 transferase activity, transferring nitrogenous groups 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0022839 monoatomic ion-gated channel activity 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0032452 histone demethylase activity 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0033612 receptor serine/threonine kinase binding 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0048019 receptor antagonist activity 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0051721 protein phosphatase 2A binding 1/787 30/18639 0.0333333333333333 0.789453621346887 0.726170151433074 0.885240623685056 GO:0001098 basal transcription machinery binding 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0001099 basal RNA polymerase II transcription machinery binding 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/787 60/18639 0.0333333333333333 0.789453621346887 0.726608421294531 0.885240623685056 GO:0061630 ubiquitin protein ligase activity 13/787 353/18639 0.0368271954674221 0.872200884774181 0.732072189151698 0.890779568504134 GO:0008017 microtubule binding 10/787 276/18639 0.036231884057971 0.858101762333573 0.733353013769017 0.890845531723488 GO:0016836 hydro-lyase activity 2/787 61/18639 0.0327868852459016 0.776511758701856 0.735009037040852 0.890845531723488 GO:0008327 methyl-CpG binding 1/787 31/18639 0.032258064516129 0.763987375496987 0.737750789340655 0.890845531723488 GO:0070325 lipoprotein particle receptor binding 1/787 31/18639 0.032258064516129 0.763987375496987 0.737750789340655 0.890845531723488 GO:0072349 modified amino acid transmembrane transporter activity 1/787 31/18639 0.032258064516129 0.763987375496987 0.737750789340655 0.890845531723488 GO:0140457 protein demethylase activity 1/787 31/18639 0.032258064516129 0.763987375496987 0.737750789340655 0.890845531723488 GO:0022804 active transmembrane transporter activity 17/787 457/18639 0.037199124726477 0.881009511787554 0.738548561315559 0.890845531723488 GO:0008378 galactosyltransferase activity 1/787 32/18639 0.03125 0.740112770012706 0.748842262297926 0.897686218137391 GO:0015106 bicarbonate transmembrane transporter activity 1/787 32/18639 0.03125 0.740112770012706 0.748842262297926 0.897686218137391 GO:0030515 snoRNA binding 1/787 32/18639 0.03125 0.740112770012706 0.748842262297926 0.897686218137391 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/787 32/18639 0.03125 0.740112770012706 0.748842262297926 0.897686218137391 GO:0140142 nucleocytoplasmic carrier activity 1/787 32/18639 0.03125 0.740112770012706 0.748842262297926 0.897686218137391 GO:0032182 ubiquitin-like protein binding 4/787 120/18639 0.0333333333333333 0.789453621346887 0.751209216348637 0.899413254099293 GO:0004540 RNA nuclease activity 4/787 121/18639 0.0330578512396694 0.782929211253111 0.756955014790193 0.904835234832377 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/787 33/18639 0.0303030303030303 0.717685110315352 0.759465207403077 0.904835234832377 GO:0042923 neuropeptide binding 1/787 33/18639 0.0303030303030303 0.717685110315352 0.759465207403077 0.904835234832377 GO:0140416 transcription regulator inhibitor activity 1/787 33/18639 0.0303030303030303 0.717685110315352 0.759465207403077 0.904835234832377 GO:0042562 hormone binding 3/787 94/18639 0.0319148936170213 0.755859850225743 0.76434836072116 0.909537081201282 GO:0120013 lipid transfer activity 2/787 65/18639 0.0307692307692308 0.728726419704819 0.766439715394901 0.910255602676116 GO:0008175 tRNA methyltransferase activity 1/787 34/18639 0.0294117647058824 0.696576724717841 0.769639392170022 0.910255602676116 GO:0008376 acetylgalactosaminyltransferase activity 1/787 34/18639 0.0294117647058824 0.696576724717841 0.769639392170022 0.910255602676116 GO:0016831 carboxy-lyase activity 1/787 34/18639 0.0294117647058824 0.696576724717841 0.769639392170022 0.910255602676116 GO:0090482 vitamin transmembrane transporter activity 1/787 34/18639 0.0294117647058824 0.696576724717841 0.769639392170022 0.910255602676116 GO:0016853 isomerase activity 6/787 180/18639 0.0333333333333333 0.789453621346887 0.7765827503362 0.914986433287081 GO:0016229 steroid dehydrogenase activity 1/787 35/18639 0.0285714285714286 0.676674532583046 0.779383751125259 0.914986433287081 GO:0034061 DNA polymerase activity 1/787 35/18639 0.0285714285714286 0.676674532583046 0.779383751125259 0.914986433287081 GO:0043015 gamma-tubulin binding 1/787 35/18639 0.0285714285714286 0.676674532583046 0.779383751125259 0.914986433287081 GO:0008173 RNA methyltransferase activity 2/787 67/18639 0.0298507462686567 0.706973392250944 0.780904905210738 0.914986433287081 GO:0016500 protein-hormone receptor activity 2/787 67/18639 0.0298507462686567 0.706973392250944 0.780904905210738 0.914986433287081 GO:0030594 neurotransmitter receptor activity 3/787 97/18639 0.0309278350515464 0.732482741455875 0.782618191188203 0.914986433287081 GO:0000993 RNA polymerase II complex binding 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0016409 palmitoyltransferase activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0045505 dynein intermediate chain binding 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/787 36/18639 0.0277777777777778 0.657878017789072 0.788716420866413 0.914986433287081 GO:0004842 ubiquitin-protein transferase activity 16/787 449/18639 0.0356347438752784 0.84395932794322 0.791236395855732 0.916814487322095 GO:0001653 peptide receptor activity 4/787 128/18639 0.03125 0.740112770012706 0.794331643481824 0.918494694196956 GO:0002039 p53 binding 2/787 69/18639 0.0289855072463768 0.686481409866858 0.794578314238355 0.918494694196956 GO:0016757 glycosyltransferase activity 9/787 267/18639 0.0337078651685393 0.798323886755279 0.799128432266513 0.922656013948613 GO:0019787 ubiquitin-like protein transferase activity 17/787 479/18639 0.0354906054279749 0.840545609367249 0.802114588599184 0.924244629885108 GO:0016298 lipase activity 4/787 130/18639 0.0307692307692308 0.728726419704819 0.804121297735201 0.924244629885108 GO:0005109 frizzled binding 1/787 38/18639 0.0263157894736842 0.623252858958069 0.806215449549626 0.924244629885108 GO:0005501 retinoid binding 1/787 38/18639 0.0263157894736842 0.623252858958069 0.806215449549626 0.924244629885108 GO:0019840 isoprenoid binding 1/787 38/18639 0.0263157894736842 0.623252858958069 0.806215449549626 0.924244629885108 GO:0042887 amide transmembrane transporter activity 1/787 38/18639 0.0263157894736842 0.623252858958069 0.806215449549626 0.924244629885108 GO:0140299 molecular sensor activity 2/787 71/18639 0.028169014084507 0.667143905363566 0.807491808765117 0.924616210272322 GO:0005179 hormone activity 4/787 132/18639 0.0303030303030303 0.717685110315352 0.81352943411755 0.928164753608014 GO:0000217 DNA secondary structure binding 1/787 39/18639 0.0256410256410256 0.607272016420682 0.814414387305899 0.928164753608014 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/787 39/18639 0.0256410256410256 0.607272016420682 0.814414387305899 0.928164753608014 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/787 39/18639 0.0256410256410256 0.607272016420682 0.814414387305899 0.928164753608014 GO:0016791 phosphatase activity 9/787 273/18639 0.032967032967033 0.780778306826592 0.819218548033281 0.932545381172703 GO:0032451 demethylase activity 1/787 40/18639 0.025 0.592090216010165 0.822266853821504 0.934163741205137 GO:0051087 protein-folding chaperone binding 4/787 134/18639 0.0298507462686567 0.706973392250944 0.822564365324812 0.934163741205137 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/787 41/18639 0.024390243902439 0.577648991229429 0.829787472459199 0.938787598789089 GO:0017080 sodium channel regulator activity 1/787 41/18639 0.024390243902439 0.577648991229429 0.829787472459199 0.938787598789089 GO:0140828 metal cation:monoatomic cation antiporter activity 1/787 41/18639 0.024390243902439 0.577648991229429 0.829787472459199 0.938787598789089 GO:0008013 beta-catenin binding 3/787 106/18639 0.0283018867924528 0.670290810577545 0.830503138372634 0.938787598789089 GO:0008236 serine-type peptidase activity 6/787 194/18639 0.0309278350515464 0.732482741455875 0.832901124149327 0.940403478545345 GO:0051536 iron-sulfur cluster binding 2/787 76/18639 0.0263157894736842 0.623252858958069 0.836660733310076 0.941735264054461 GO:0016859 cis-trans isomerase activity 1/787 42/18639 0.0238095238095238 0.563895443819205 0.836990250132852 0.941735264054461 GO:0043175 RNA polymerase core enzyme binding 1/787 42/18639 0.0238095238095238 0.563895443819205 0.836990250132852 0.941735264054461 GO:0051540 metal cluster binding 2/787 77/18639 0.025974025974026 0.615158665984587 0.841992279216362 0.944343055731301 GO:0008200 ion channel inhibitor activity 1/787 43/18639 0.0232558139534884 0.550781596288526 0.843888603262144 0.944343055731301 GO:0008375 acetylglucosaminyltransferase activity 1/787 43/18639 0.0232558139534884 0.550781596288526 0.843888603262144 0.944343055731301 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/787 43/18639 0.0232558139534884 0.550781596288526 0.843888603262144 0.944343055731301 GO:0042578 phosphoric ester hydrolase activity 12/787 363/18639 0.0330578512396694 0.782929211253111 0.844170723351977 0.944343055731301 GO:0017171 serine hydrolase activity 6/787 198/18639 0.0303030303030303 0.717685110315352 0.846723491726767 0.946108757729218 GO:0016248 channel inhibitor activity 1/787 44/18639 0.0227272727272727 0.538263832736514 0.85049538263581 0.948141235980909 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/787 44/18639 0.0227272727272727 0.538263832736514 0.85049538263581 0.948141235980909 GO:0015370 solute:sodium symporter activity 2/787 79/18639 0.0253164556962025 0.599585028871053 0.852184342952445 0.948934629594982 GO:0051539 4 iron, 4 sulfur cluster binding 1/787 45/18639 0.0222222222222222 0.526302414231258 0.856822897229283 0.951916513969832 GO:0141110 transporter inhibitor activity 1/787 45/18639 0.0222222222222222 0.526302414231258 0.856822897229283 0.951916513969832 GO:0140030 modification-dependent protein binding 5/787 173/18639 0.0289017341040462 0.684497359549324 0.859878306128368 0.954219240286452 GO:0005504 fatty acid binding 1/787 47/18639 0.0212765957446809 0.503906566817162 0.868686794846962 0.959046602212072 GO:0061749 forked DNA-dependent helicase activity 1/787 47/18639 0.0212765957446809 0.503906566817162 0.868686794846962 0.959046602212072 GO:0099095 ligand-gated monoatomic anion channel activity 1/787 47/18639 0.0212765957446809 0.503906566817162 0.868686794846962 0.959046602212072 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/787 47/18639 0.0212765957446809 0.503906566817162 0.868686794846962 0.959046602212072 GO:0015293 symporter activity 4/787 146/18639 0.0273972602739726 0.648865990148126 0.869443254131444 0.959046602212072 GO:0015294 solute:monoatomic cation symporter activity 3/787 116/18639 0.0258620689655172 0.612507120010516 0.872809281875279 0.959046602212072 GO:0015085 calcium ion transmembrane transporter activity 4/787 147/18639 0.0272108843537415 0.644451935793377 0.872821191795405 0.959046602212072 GO:0009378 four-way junction helicase activity 1/787 48/18639 0.0208333333333333 0.493408513341804 0.874245287341338 0.959046602212072 GO:0036121 double-stranded DNA helicase activity 1/787 48/18639 0.0208333333333333 0.493408513341804 0.874245287341338 0.959046602212072 GO:0043138 3'-5' DNA helicase activity 1/787 48/18639 0.0208333333333333 0.493408513341804 0.874245287341338 0.959046602212072 GO:0004527 exonuclease activity 2/787 84/18639 0.0238095238095238 0.563895443819205 0.875092986158492 0.959046602212072 GO:0060590 ATPase regulator activity 1/787 49/18639 0.0204081632653061 0.483338951845033 0.879568774989252 0.962312560852393 GO:0022853 active monoatomic ion transmembrane transporter activity 3/787 118/18639 0.0254237288135593 0.602125643400168 0.880055153488079 0.962312560852393 GO:0015605 organophosphate ester transmembrane transporter activity 1/787 50/18639 0.02 0.473672172808132 0.88466718134124 0.96626752877654 GO:0030544 Hsp70 protein binding 1/787 51/18639 0.0196078431372549 0.464384483145228 0.889550011417331 0.970509057400256 GO:0004197 cysteine-type endopeptidase activity 2/787 88/18639 0.0227272727272727 0.538263832736514 0.891014201990564 0.971015477141232 GO:0008528 G protein-coupled peptide receptor activity 3/787 122/18639 0.0245901639344262 0.582383819026392 0.893453986437666 0.972582758779119 GO:0015078 proton transmembrane transporter activity 5/787 185/18639 0.027027027027027 0.6400975308218 0.895315187131459 0.97351740952368 GO:0005246 calcium channel regulator activity 1/787 53/18639 0.0188679245283019 0.44686054038503 0.898704975208597 0.973931396124495 GO:0008146 sulfotransferase activity 1/787 53/18639 0.0188679245283019 0.44686054038503 0.898704975208597 0.973931396124495 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/787 53/18639 0.0188679245283019 0.44686054038503 0.898704975208597 0.973931396124495 GO:0050661 NADP binding 1/787 54/18639 0.0185185185185185 0.438585345192715 0.902994181305166 0.977488684556651 GO:0051213 dioxygenase activity 2/787 93/18639 0.021505376344086 0.509324916997992 0.908265565169529 0.982100071024068 GO:0030170 pyridoxal phosphate binding 1/787 56/18639 0.0178571428571429 0.422921582864404 0.911036056428607 0.982906678657975 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/787 56/18639 0.0178571428571429 0.422921582864404 0.911036056428607 0.982906678657975 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/787 57/18639 0.0175438596491228 0.415501905972046 0.914803727073319 0.98478316960997 GO:0070279 vitamin B6 binding 1/787 57/18639 0.0175438596491228 0.415501905972046 0.914803727073319 0.98478316960997 GO:0016407 acetyltransferase activity 2/787 96/18639 0.0208333333333333 0.493408513341804 0.917353692484059 0.986434590699913 GO:0017116 single-stranded DNA helicase activity 1/787 58/18639 0.0172413793103448 0.40833808000701 0.91841202902108 0.986480177189678 GO:0031593 polyubiquitin modification-dependent protein binding 1/787 59/18639 0.0169491525423729 0.401417095600112 0.921867695194075 0.988059382345219 GO:0016758 hexosyltransferase activity 5/787 197/18639 0.0253807106598985 0.601106818284432 0.922728333787623 0.988059382345219 GO:0008170 N-methyltransferase activity 2/787 98/18639 0.0204081632653061 0.483338951845033 0.922934974034103 0.988059382345219 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/787 229/18639 0.0262008733624454 0.620531230753012 0.92497084000984 0.989148332213165 GO:0016829 lyase activity 5/787 200/18639 0.025 0.592090216010165 0.928502394866378 0.991832591215901 GO:0022824 transmitter-gated monoatomic ion channel activity 1/787 63/18639 0.0158730158730159 0.37593029587947 0.934288964952204 0.995822815552788 GO:0022835 transmitter-gated channel activity 1/787 63/18639 0.0158730158730159 0.37593029587947 0.934288964952204 0.995822815552788 GO:0004252 serine-type endopeptidase activity 4/787 176/18639 0.0227272727272727 0.538263832736514 0.942741397099097 0.999925035208946 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/787 67/18639 0.0149253731343284 0.353486696125472 0.944737639425345 0.999925035208946 GO:0004843 cysteine-type deubiquitinase activity 2/787 108/18639 0.0185185185185185 0.438585345192715 0.94589337896375 0.999925035208946 GO:0008194 UDP-glycosyltransferase activity 3/787 145/18639 0.0206896551724138 0.490005696008413 0.947484846024137 0.999925035208946 GO:0008080 N-acetyltransferase activity 1/787 69/18639 0.0144927536231884 0.343240704933429 0.949322079437553 0.999925035208946 GO:0098960 postsynaptic neurotransmitter receptor activity 1/787 69/18639 0.0144927536231884 0.343240704933429 0.949322079437553 0.999925035208946 GO:0016782 transferase activity, transferring sulphur-containing groups 1/787 70/18639 0.0142857142857143 0.338337266291523 0.951469818989661 0.999925035208946 GO:0015276 ligand-gated monoatomic ion channel activity 4/787 186/18639 0.021505376344086 0.509324916997992 0.957162412785506 0.999925035208946 GO:0004521 RNA endonuclease activity 1/787 73/18639 0.0136986301369863 0.324432995074063 0.957382784109699 0.999925035208946 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/787 73/18639 0.0136986301369863 0.324432995074063 0.957382784109699 0.999925035208946 GO:0101005 deubiquitinase activity 2/787 115/18639 0.0173913043478261 0.411888845920115 0.957915257581697 0.999925035208946 GO:0008234 cysteine-type peptidase activity 4/787 187/18639 0.0213903743315508 0.506601254340248 0.958403109876852 0.999925035208946 GO:0003678 DNA helicase activity 1/787 74/18639 0.0135135135135135 0.3200487654109 0.95918929864733 0.999925035208946 GO:0003684 damaged DNA binding 1/787 74/18639 0.0135135135135135 0.3200487654109 0.95918929864733 0.999925035208946 GO:0035064 methylated histone binding 1/787 74/18639 0.0135135135135135 0.3200487654109 0.95918929864733 0.999925035208946 GO:0022834 ligand-gated channel activity 4/787 188/18639 0.0212765957446809 0.503906566817162 0.959610529062474 0.999925035208946 GO:0004386 helicase activity 3/787 155/18639 0.0193548387096774 0.458392425298192 0.961856767082632 0.999925035208946 GO:0140034 methylation-dependent protein binding 1/787 76/18639 0.0131578947368421 0.311626429479034 0.962576110738033 0.999925035208946 GO:0003724 RNA helicase activity 1/787 77/18639 0.012987012987013 0.307579332992294 0.96416274010016 0.999925035208946 GO:0008186 ATP-dependent activity, acting on RNA 1/787 79/18639 0.0126582278481013 0.299792514435527 0.96713728484667 0.999925035208946 GO:0005216 monoatomic ion channel activity 12/787 448/18639 0.0267857142857143 0.634382374296605 0.968275589657958 0.999925035208946 GO:0005267 potassium channel activity 2/787 124/18639 0.0161290322580645 0.381993687748494 0.969653425090711 0.999925035208946 GO:0019783 ubiquitin-like protein peptidase activity 2/787 127/18639 0.015748031496063 0.372970214809553 0.972811890935114 0.999925035208946 GO:0005262 calcium channel activity 2/787 131/18639 0.0152671755725191 0.361581811303918 0.976533225270064 0.999925035208946 GO:0004175 endopeptidase activity 10/787 405/18639 0.0246913580246914 0.584780460256953 0.978449046480191 0.999925035208946 GO:0099094 ligand-gated monoatomic cation channel activity 2/787 136/18639 0.0147058823529412 0.348288362358921 0.980496568088474 0.999925035208946 GO:0140101 catalytic activity, acting on a tRNA 2/787 139/18639 0.0143884892086331 0.34077134734398 0.982554459918258 0.999925035208946 GO:0016410 N-acyltransferase activity 1/787 94/18639 0.0106382978723404 0.251953283408581 0.982847156530815 0.999925035208946 GO:0022843 voltage-gated monoatomic cation channel activity 2/787 143/18639 0.013986013986014 0.331239281684008 0.984973099395846 0.999925035208946 GO:0005249 voltage-gated potassium channel activity 1/787 98/18639 0.0102040816326531 0.241669475922516 0.985578887911969 0.999925035208946 GO:0140597 protein carrier chaperone 3/787 188/18639 0.0159574468085106 0.377929925112871 0.987261826968256 0.999925035208946 GO:0019842 vitamin binding 2/787 150/18639 0.0133333333333333 0.315781448538755 0.98844417104211 0.999925035208946 GO:0000510 H3-H4 histone complex chaperone activity 2/787 151/18639 0.0132450331125828 0.313690180667637 0.988871366655212 0.999925035208946 GO:0140584 chromatin extrusion motor activity 2/787 151/18639 0.0132450331125828 0.313690180667637 0.988871366655212 0.999925035208946 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/787 151/18639 0.0132450331125828 0.313690180667637 0.988871366655212 0.999925035208946 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/787 151/18639 0.0132450331125828 0.313690180667637 0.988871366655212 0.999925035208946 GO:0015616 DNA translocase activity 2/787 152/18639 0.0131578947368421 0.311626429479034 0.989283150599663 0.999925035208946 GO:0140674 ATP-dependent histone chaperone activity 2/787 152/18639 0.0131578947368421 0.311626429479034 0.989283150599663 0.999925035208946 GO:0061775 cohesin loader activity 2/787 153/18639 0.0130718954248366 0.309589655430152 0.989680060512184 0.999925035208946 GO:0140658 ATP-dependent chromatin remodeler activity 2/787 158/18639 0.0126582278481013 0.299792514435527 0.991459097657262 0.999925035208946 GO:0003689 DNA clamp loader activity 2/787 160/18639 0.0125 0.296045108005083 0.992083504933663 0.999925035208946 GO:0015079 potassium ion transmembrane transporter activity 2/787 160/18639 0.0125 0.296045108005083 0.992083504933663 0.999925035208946 GO:0046873 metal ion transmembrane transporter activity 10/787 450/18639 0.0222222222222222 0.526302414231258 0.992713235534443 0.999925035208946 GO:0022836 gated channel activity 6/787 318/18639 0.0188679245283019 0.44686054038503 0.993168463728615 0.999925035208946 GO:0015081 sodium ion transmembrane transporter activity 2/787 164/18639 0.0121951219512195 0.288824495614715 0.993201332539195 0.999925035208946 GO:0140713 histone chaperone activity 2/787 164/18639 0.0121951219512195 0.288824495614715 0.993201332539195 0.999925035208946 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/787 167/18639 0.0119760479041916 0.283636031621636 0.993936830944697 0.999925035208946 GO:0016874 ligase activity 2/787 167/18639 0.0119760479041916 0.283636031621636 0.993936830944697 0.999925035208946 GO:0140104 molecular carrier activity 4/787 249/18639 0.0160642570281124 0.380459576552717 0.993975712955959 0.999925035208946 GO:0016741 transferase activity, transferring one-carbon groups 3/787 215/18639 0.013953488372093 0.330468957773115 0.995002357765276 0.999925035208946 GO:0005244 voltage-gated monoatomic ion channel activity 2/787 173/18639 0.0115606936416185 0.27379894381973 0.995181623452897 0.999925035208946 GO:0022832 voltage-gated channel activity 2/787 175/18639 0.0114285714285714 0.270669813033218 0.995537953572742 0.999925035208946 GO:0140097 catalytic activity, acting on DNA 6/787 336/18639 0.0178571428571429 0.422921582864404 0.99598750972089 0.999925035208946 GO:0005261 monoatomic cation channel activity 6/787 341/18639 0.0175953079178886 0.41672038663472 0.996546844737207 0.999925035208946 GO:0140098 catalytic activity, acting on RNA 7/787 387/18639 0.0180878552971576 0.428385686002187 0.99744036742042 0.999925035208946 GO:0008168 methyltransferase activity 2/787 204/18639 0.00980392156862745 0.232192241572614 0.998552352456033 0.999925035208946 GO:0008094 ATP-dependent activity, acting on DNA 2/787 210/18639 0.00952380952380952 0.225558177527682 0.99885592881175 0.999925035208946 GO:0003735 structural constituent of ribosome 1/787 175/18639 0.00571428571428571 0.135334906516609 0.999492416126194 0.999925035208946 GO:0045182 translation regulator activity 4/787 356/18639 0.0112359550561798 0.26610796225176 0.999849201300276 0.999925035208946 GO:0030371 translation repressor activity 3/787 329/18639 0.00911854103343465 0.215959957207355 0.999925035208946 0.999925035208946