category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	51/587	180/9376	4.52561044860875	HLA-C/NFKBIA/HLA-A/HLA-B/B2M/HLA-DQA2/HLA-F/IRF7/OAS1/HLA-DPB1/STAT1/IFNGR2/PILRA/HLA-E/OAS2/HLA-DPA1/SRSF5/BID/IL1B/SOCS3/BST2/IFIH1/TNF/HLA-DRA/TAP1/OAS3/CFP/EIF2AK2/TAP2/SRSF3/JAK2/HLA-DQA1/BIRC3/TLR2/SRSF9/MYD88/BAX/IRAK1/TAPBP/STAT2/TNFRSF14/NFKB1/SP100/ALYREF/CCL5/JAK1/SRSF4/APAF1/TRADD/RELA/RHEB	12.3425828873842
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	51/587	187/9376	4.35620257085334	NFKBIA/JUN/GBP2/GBP1/GBP4/IRF7/OAS1/STAT1/CYBA/TNFAIP3/GBP5/OAS2/CXCL8/CYBB/CASP1/IL1B/TNF/GPSM3/RHOA/OAS3/GABARAP/CXCL3/GABARAPL2/CXCL2/CARD16/NLRP3/NAMPT/PYCARD/BIRC3/MAP1LC3B/RIPK2/VDAC2/RBCK1/MYD88/STAT2/NFKB1/CASP4/CCL5/GBP3/JAK1/TANK/SUGT1/MEFV/AIM2/GABARAPL1/PKN1/PSTPIP1/GSDMD/RELA/PRKCD/TXNIP	11.980358107037
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	53/587	205/9376	4.12953837204471	HLA-C/NFKBIA/HLA-A/HLA-B/B2M/JUN/ISG15/GADD45B/HLA-DQA2/HLA-F/IRF7/OAS1/HLA-DPB1/RAC1/STAT1/TNFAIP3/HLA-E/OAS2/HLA-DPA1/BID/TNF/HLA-DRA/TAP1/CXCL10/OAS3/SAP30/RELB/EIF2AK2/TAP2/STAT3/HLA-DQA1/PSMD4/TLR2/MYD88/BAX/IRAK1/TAPBP/CD58/CD40/STAT2/NFKB1/LYN/JAK1/ICAM1/CDKN1A/APAF1/TRADD/NFKB2/CD44/RUNX3/RELA/ADRM1/PSMC5	11.7080298579725
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	32/587	78/9376	6.5529201065828	NFKBIA/JUN/FOS/HLA-DQA2/NCF1/HLA-DPB1/STAT1/CYBA/NCF2/IFNGR2/EEF1A1/MARCKSL1/HLA-DPA1/CYBB/IL1B/TNF/PTPN6/HLA-DRA/FCGR2A/FCGR3A/TGFB1/JAK2/HLA-DQA1/TLR2/MYD88/IRAK1/PTGS2/NFKB1/NCF4/JAK1/FCGR1A/RELA	12.7264979549939
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/587	216/9376	3.62344627421288	NFKBIA/JUN/CCL3L3/FOS/SOD2/CCL3/NCF1/IRF7/RAC1/HSPA1A/CYBA/NCF2/TNFSF10/CXCL8/CYBB/CASP1/BID/IL1B/TNF/CD14/RHOA/ERO1A/OLR1/CXCL3/CALM1/CXCL2/STAT3/NLRP3/JAK2/RAP1B/PYCARD/TLR2/MYD88/BAX/VAV1/IRAK1/CD40/NFKB1/HSPA6/NCF4/LYN/CCL5/TANK/ICAM1/HSPA1B/RAP1A/APAF1/RELA/TNFRSF10A	10.0805973956176
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	43/587	173/9376	3.9701036917411	NFKBIA/HLA-DQA2/MX1/MX2/IRF7/OAS1/HLA-DPB1/STAT1/IFNGR2/RSAD2/OAS2/TNFSF10/HLA-DPA1/CXCL8/CASP1/BID/IL1B/SOCS3/IFIH1/TNF/HLA-DRA/CXCL10/OAS3/EIF2AK2/NLRP3/JAK2/PYCARD/HLA-DQA1/CALCOCO2/MYD88/BAX/ACTG1/STAT2/NFKB1/CCL5/JAK1/ICAM1/ADAR/APAF1/TRADD/DNAJB1/RELA/TNFRSF10A	10.1897823734256
Human Diseases	Infectious disease: viral	hsa05162	Measles	37/587	136/9376	4.34552560376791	NFKBIA/JUN/FOS/MX1/MX2/IRF7/OAS1/STAT1/HSPA1A/TNFAIP3/OAS2/BID/IL1B/IFIH1/OAS3/EIF3H/CSNK2B/MSN/EIF2AK2/STAT3/FCGR2B/TLR2/MYD88/BAX/IRAK1/IL2RG/STAT2/NFKB1/HSPA6/RAB9A/JAK1/HSPA1B/ADAR/APAF1/TRADD/RELA/BBC3	10.1562359790916
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/587	248/9376	3.28471726108699	NFKBIA/JUN/FOS/GAPDH/ARPC3/RHOB/RAC1/S100A10/TNFSF10/CXCL8/RRAS/CASP1/DYNLT1/IL1B/PFN1/TNF/RALA/CD14/BRK1/RHOA/CYTH1/NLRP3/ARF6/PYCARD/BIRC3/MYL12A/TLR2/RIPK2/MYD88/BAX/STX10/IRAK1/DYNC1LI1/ACTG1/DYNLL1/MLKL/NFKB1/RPS3/MYL12B/PAK1/RAB9A/CASP4/TUBA1A/ARPC5/DYNLT3/TRADD/PKN1/GSDMD/RELA/RHOH/TNFRSF10A	9.42335265187497
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	49/587	238/9376	3.28850586231085	NFKBIA/JUN/ISG15/FOS/MX1/RPL36A/MX2/OAS1/STAT1/OAS2/CXCL8/CYBB/CASP1/RPS10/IL1B/RPS9/RPL3/IFIH1/TNF/CXCL10/OAS3/FCGR2A/RPL7A/RPL36AL/RPL24/RPS3A/EIF2AK2/STAT3/RPL8/NLRP3/TLR2/RPS4X/MYD88/IRAK1/STAT2/RPS27L/NFKB1/RPS3/RPL9/RPS26/RPL26/RPL19/CFD/JAK1/ADAR/RPL10/RELA/RPL10A/RPL17	9.24165788712557
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/587	142/9376	4.04942774192	NFKBIA/JUN/FOS/FOSB/JUND/JUNB/NCF1/GRB2/RAC1/STAT1/CYBA/NCF2/IFNGR2/OSCAR/IL1B/SOCS3/TNF/LILRB4/TYROBP/SPI1/LILRA2/LILRB1/FCGR2A/FCGR3A/TGFB1/RELB/LILRB2/FCGR2B/LILRA5/STAT2/NFKB1/NCF4/JAK1/FCGR1A/NFKB2/RELA	9.46242696842356
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	38/587	181/9376	3.35339350758139	CEBPB/HLA-DQA2/HLA-DPB1/STAT1/CLEC4E/IFNGR2/HLA-DPA1/BID/IL1B/LSP1/PLK3/TNF/HLA-DRA/CD14/RHOA/CORO1A/FCGR2A/FCGR3A/CALM1/FCER1G/TGFB1/FCGR2B/JAK2/HLA-DQA1/TLR2/RIPK2/MYD88/BAX/IRAK1/MRC2/NFKB1/CTSS/SPHK1/JAK1/FCGR1A/APAF1/TRADD/RELA	8.26214720118549
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	28/587	105/9376	4.25939806927882	NFKBIA/CCL4L2/GADD45B/CCL4/TNFAIP3/BCL2A1/CXCL8/IL1B/TNF/TNFSF13B/CD14/CXCL3/CSNK2B/CXCL2/RELB/BIRC3/MYD88/IRAK1/CD40/PTGS2/NFKB1/LYN/LTB/ICAM1/TRADD/NFKB2/RELA/UBE2I	8.67968011021339
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	28/587	109/9376	4.10308988325024	NFKBIA/JUN/CCL3L3/FOS/CCL4L2/CCL3/CCL4/IRF7/RAC1/STAT1/CXCL8/IL1B/TNF/CD86/CXCL10/CD14/MAP3K8/TLR2/MYD88/IRAK1/CD40/STAT2/CXCL9/NFKB1/CXCL11/CCL5/JAK1/RELA	8.42118056447731
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/587	196/9376	3.09675624934812	HLA-C/NFKBIA/HLA-A/HLA-B/JUN/FOS/UBC/HLA-F/IRF7/VEGFA/RAC1/STAT1/HLA-E/ZFP36/CXCL8/BID/CD86/ATG3/CXCL3/CALM1/CXCL2/EIF2AK2/STAT3/JAK2/GNG5/MAP1LC3B/BAX/STAT2/PTGS2/NFKB1/HCK/CLEC2B/LYN/JAK1/ICAM1/CDKN1A/TRADD/RELA	7.66636685962181
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	33/587	155/9376	3.40064845853712	HLA-C/HLA-A/HLA-B/HLA-DQA2/NCF1/HLA-F/HLA-DPB1/RAC1/CYBA/NCF2/HLA-E/HLA-DPA1/CYBB/HLA-DRA/TAP1/CD14/ATP6V1F/CORO1A/OLR1/FCGR2A/FCGR3A/TAP2/FCGR2B/HLA-DQA1/TLR2/DYNC1LI1/ACTG1/MRC2/NCF4/CTSS/FCGR1A/TUBA1A/STX18	7.788258594297
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/587	56/9376	5.41932343635921	NFKBIA/HSPA1A/EEF1A1/CXCL8/CASP1/IL1B/TNF/CD14/CXCL3/CXCL2/PYCARD/TLR2/MYD88/NFKB1/HSPA6/HSPA1B/APAF1/NFKB2/RELA	8.57189418483214
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	36/587	193/9376	2.97937170649037	NFKBIA/CCL3L3/CCL4L2/CCL3/CCL4/NCF1/CXCR4/GRB2/RAC1/STAT1/CXCL8/CXCL10/RHOA/WAS/CXCL3/GNAI2/CXCL2/STAT3/JAK2/RAP1B/GNG5/FGR/VAV1/CXCL16/STAT2/CXCL9/NFKB1/HCK/PAK1/LYN/CXCL11/CCL5/RAP1A/RELA/PRKCD/PPBP	7.18040064104739
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	24/587	95/9376	4.0352192235273	JUN/CCL3L3/FOS/CCL3/HLA-DQA2/HLA-DPB1/VEGFA/HLA-DPA1/CXCL8/IL1B/TNF/CD86/HLA-DRA/TNFSF13B/ATP6V1F/CXCL3/TGFB1/CXCL2/HLA-DQA1/TLR2/IL15/CCL5/LTB/ICAM1	7.68403681685908
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	22/587	82/9376	4.28537000872564	HLA-C/HLA-A/HLA-B/B2M/PSME2/HLA-DQA2/HLA-F/HLA-DPB1/HSPA1A/HLA-E/HLA-DPA1/IFI30/TNF/HLA-DRA/TAP1/PSME1/TAP2/HLA-DQA1/TAPBP/HSPA6/CTSS/HSPA1B	7.72191180329164
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/587	112/9376	3.70795814066683	NFKBIA/HLA-DQA2/HLA-DPB1/STAT1/HSPA1A/IFNGR2/HLA-DPA1/TNF/HLA-DRA/GNAI2/TGFB1/STAT3/JAK2/HLA-DQA1/BIRC3/TLR2/MYD88/IRAK1/CD40/PPIF/NFKB1/HSPA6/ALOX5/JAK1/HSPA1B/RELA	7.45052097194355
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	25/587	105/9376	3.80303399042752	NFKBIA/JUN/STAT1/CLEC4E/IRF1/RRAS/CASP1/IL1B/LSP1/PLK3/TNF/RHOA/CALM1/FCER1G/RELB/NLRP3/PYCARD/STAT2/PTGS2/NFKB1/PAK1/NFKB2/CLEC4D/RELA/PRKCD	7.46439614242914
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	42/587	253/9376	2.65160156486725	NFKBIA/JUN/UBC/ARPC3/RAC1/CXCL8/CASP1/IL1B/PFN1/TNF/CD14/HK2/RHOA/CYTH1/NLRP3/ARF6/PYCARD/MYL12A/CALCOCO2/MAP1LC3B/RIPK2/HCLS1/RBCK1/MYD88/BAX/TNIP1/RBX1/CUL1/ACTG1/UBE2D1/TIFA/UBE2D2/NFKB1/MYL12B/CASP4/CCL5/ARPC5/TRADD/CD44/UBE2V2/RELA/PRKCD	6.88226934873186
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/587	200/9376	2.79522998296422	NFKBIA/JUN/FOS/GAPDH/ARPC3/RAC1/TNFSF10/CXCL8/CASP1/IL1B/TNF/PTPN6/BRK1/RHOA/MYO1G/FCGR2A/CYTH1/NLRP3/ARF6/PYCARD/HCLS1/MYD88/BAX/NCL/IRAK1/ACTG1/NFKB1/RPS3/PAK1/CASP4/TUBA1A/ARPC5/TRADD/RELA/TNFRSF10A	6.63198209385325
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/587	78/9376	4.09557506661425	JUN/FOS/CXCL8/IRF1/CASP1/IL1B/IRF8/TNF/CD14/RHOA/CALM1/GNAI2/SERPING1/NLRP3/PYCARD/MYD88/CFL1/IRAK1/NFKB1/RELA	7.09461490506483
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/587	227/9376	2.60348670534113	HLA-C/NFKBIA/HLA-A/HLA-B/B2M/CCL3L3/CCL4L2/CCL3/CCL4/CXCR4/HLA-F/GRB2/VEGFA/RAC1/HLA-E/CXCL8/BID/IL1B/TNF/TAP1/RHOA/CALM1/GNAI2/TAP2/STAT3/GNG5/BAX/TAPBP/PTGS2/NFKB1/CCL5/JAK1/CDKN1A/TRADD/RELA/RHEB/PTGER4	6.32013616197821
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/587	83/9376	3.84885367705917	NFKBIA/CCL4L2/CCL4/IRF7/CASP1/IL1B/CXCL10/NLRP3/PYCARD/DNASE2/MLKL/NFKB1/POLR1D/CCL5/MEFV/ADAR/POLR2E/AIM2/GSDMD/RELA	6.73699426671695
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/587	214/9376	2.61236447006002	HLA-C/NFKBIA/HLA-A/HLA-B/B2M/JUN/FOS/APOBEC3A/CXCR4/HLA-F/RAC1/HLA-E/BID/APOBEC3G/BST2/TNF/TAP1/CALM1/GNAI2/TAP2/TLR2/GNG5/TNFRSF1B/MYD88/BAX/RBX1/CUL1/CFL1/IRAK1/TAPBP/NFKB1/PAK1/TRADD/AP1S2/RELA	6.16609084715217
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	24/587	119/9376	3.2213934977739	NFKBIA/JUN/FOS/CEBPB/JUNB/TNFAIP3/IRF1/IL1B/SOCS3/TNF/CXCL10/CXCL3/MAP3K8/CXCL2/BIRC3/TNFRSF1B/PTGS2/MLKL/NFKB1/IL15/CCL5/ICAM1/TRADD/RELA	6.30229607113298
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/587	39/9376	5.32424758659852	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/HLA-DPB1/HLA-E/HLA-DPA1/TNF/CD86/HLA-DRA/HLA-DQA1/CD40	6.99317075006222
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/587	224/9376	2.49574105621806	HLA-C/NFKBIA/HLA-A/HLA-B/B2M/JUN/FOS/HLA-DQA2/HLA-F/HLA-DPB1/HLA-E/ZFP36/HLA-DPA1/TNF/HLA-DRA/EGR1/SPI1/TGFB1/RELB/HLA-DQA1/VDAC2/BAX/IL2RG/CD40/NFKB1/IL15/CDC26/JAK1/POLB/ICAM1/CDKN1A/NFKB2/ANAPC10/ANAPC16/RELA	5.85541087104296
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	29/587	168/9376	2.75719964305995	FTH1/STAT1/TNFAIP3/IFNGR2/TNFSF10/CYBB/CASP1/BID/IL1B/CHMP5/TNF/CHMP1B/EIF2AK2/STAT3/CHMP2A/NLRP3/JAK2/PYCARD/BIRC3/VDAC2/RBCK1/BAX/CHMP4A/CHMP2B/STAT2/MLKL/JAK1/TRADD/TNFRSF10A	5.93920134446618
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/587	44/9376	4.71921945175778	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/HLA-DPB1/HLA-E/HLA-DPA1/IL1B/TNF/CD86/HLA-DRA/HLA-DQA1	6.39036602663169
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/587	66/9376	3.87218006298074	JUN/HLA-DQA2/HLA-DPB1/STAT1/IFNGR2/HLA-DPA1/IL1B/TNF/HLA-DRA/TGFB1/STAT3/HLA-DQA1/TLR2/IL2RG/NFKB1/RELA	6.051231210302
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/587	45/9376	4.61434790838539	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/HLA-DPB1/HLA-E/HLA-DPA1/IL1B/TNF/CD86/HLA-DRA/HLA-DQA1	6.28068587765121
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/587	91/9376	3.33496826852875	NFKBIA/JUN/FOS/GRB2/RAC1/PTPN6/LILRB4/DAPP1/LILRA2/LILRB1/IFITM1/LILRB2/FCGR2B/LILRA5/VAV1/NFKB1/LYN/RELA/CD72	5.78423170643444
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/587	46/9376	4.51403599733353	PSMB9/PSME2/PSMB8/PSME1/PSMB10/PSMD4/PSMB3/PSMF1/PSMA5/PSMA2/PSMD9/ADRM1/PSMC5	6.17417957330193
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/587	156/9376	2.66212379329926	NFKBIA/MX1/IFIT1/MX2/GRB2/IRF7/OAS1/YWHAH/STAT1/RSAD2/OAS2/BID/SOCS3/TNF/CXCL10/OAS3/EIF2AK2/STAT3/BAX/STAT2/NFKB1/JAK1/CDKN1A/APAF1/TRADD/RELA	5.40997379801479
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/587	138/9376	2.7778683060514	NFKBIA/JUN/FOS/ARPC3/RAC1/CXCL8/CASP1/IL1B/TNF/RHOA/WAS/FCGR2A/NLRP3/ARF6/PYCARD/MYD88/VAV1/IRAK1/ACTG1/NFKB1/MEFV/ARPC5/PKN1/RELA	5.43732269950364
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/587	70/9376	3.65091263081042	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/HLA-DPB1/RAC1/HLA-E/HLA-DPA1/BID/CD86/HLA-DRA/HLA-DQA1/ACTG1/CD40/ICAM1	5.75304626976539
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/587	98/9376	3.09675624934812	NCF1/ARPC3/RAC1/MARCKSL1/VASP/WAS/FCGR2A/FCGR3A/ARF6/FCGR2B/CFL1/VAV1/HCK/PAK1/SPHK1/LYN/FCGR1A/ARPC5/PRKCD	5.39223432249157
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	21/587	116/9376	2.89161722375609	NCF1/CXCR4/RAC1/CYBA/NCF2/CYBB/VASP/RHOA/GNAI2/RASSF5/MSN/RAP1B/MYL12A/VAV1/ACTG1/MYL12B/NCF4/ICAM1/RAP1A/RHOH/CTNNA1	5.29775314051714
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/587	100/9376	3.03482112436116	CCL3L3/CCL4L2/CCL3/CCL4/CXCR4/TNFSF10/CXCL8/TNF/CXCL10/CXCL3/CXCL2/TNFRSF1B/IL2RG/CXCL9/TNFRSF14/CXCL11/CCL5/PPBP/TNFRSF10A	5.2866532267776
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	20/587	109/9376	2.93077848803588	NFKBIA/JUN/FOS/HLA-DQA2/HLA-DPB1/STAT1/IFNGR2/HLA-DPA1/IL1B/HLA-DRA/TGFB1/STAT3/EBI3/JAK2/HLA-DQA1/IL2RG/NFKB1/RARA/JAK1/RELA	5.23975614290883
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/587	137/9376	2.68155535383429	NFKBIA/JUN/FOS/GADD45B/BCL2A1/CTSH/TNFSF10/BID/TNF/MCL1/BIRC3/BAX/ACTG1/NFKB1/CTSS/TUBA1A/APAF1/TRADD/IL3RA/LMNB1/RELA/BBC3/TNFRSF10A	5.12382070961265
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/587	133/9376	2.64210782492859	HLA-C/HLA-A/HLA-B/CD48/GRB2/RAC1/IFNGR2/HLA-E/TNFSF10/BID/TNF/PTPN6/TYROBP/FCGR3A/FCER1G/ICAM2/VAV1/HCST/LAT2/PAK1/ICAM1/TNFRSF10A	4.92896768807956
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/587	93/9376	2.91974867652177	NFKBIA/JUN/FOS/HLA-DQA2/HLA-DPB1/STAT1/IFNGR2/HLA-DPA1/HLA-DRA/JAK2/HLA-DQA1/IL2RG/NFKB1/JAK1/RUNX3/RELA/NOTCH1	4.8081347726373
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/587	103/9376	2.7913531036536	NFKBIA/JUN/CCL3L3/FOS/CCL3/IFNGR2/CXCL8/IL1B/TNF/GNAI2/TGFB1/GNA15/TLR2/MYD88/IRAK1/NFKB1/CCL5/RELA	4.72416045123819
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/587	94/9376	2.88868752038856	NFKBIA/JUN/FOS/FOSB/CEBPB/JUND/TNFAIP3/CXCL8/IL1B/TNF/CXCL10/CXCL3/CXCL2/PTGS2/NFKB1/TRADD/RELA	4.75596020500663
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/587	54/9376	3.54949839106568	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/HLA-DPB1/HLA-E/HLA-DPA1/CD86/HLA-DRA/HLA-DQA1/CD40	4.85547843312617
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/587	110/9376	2.613721542512	LDHA/ALDOA/GAPDH/TIMP1/VEGFA/IFNGR2/CYBB/ENO1/PGK1/HK2/STAT3/RBX1/NFKB1/CDKN1A/EIF4E2/RELA/PFKFB3/ALDOC	4.39960561783892
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/587	101/9376	2.68848145461906	JUN/VEGFA/RAC1/STAT1/CXCL8/CYBB/IL1B/TNF/EGR1/TGFB1/STAT3/JAK2/BAX/NFKB1/ICAM1/RELA/PRKCD	4.40894802610823
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/587	163/9376	2.25382259800796	NFKBIA/JUN/FOS/GRB2/IRF7/STAT1/CXCL8/BID/IFIH1/TNF/TGFB1/STAT3/JAK2/TLR2/MYD88/BAX/IRAK1/STAT2/NFKB1/JAK1/CDKN1A/APAF1/RELA	4.17315308347237
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/587	50/9376	3.51400340715503	HLA-DQA2/CXCR4/HLA-DPB1/HLA-DPA1/CD86/HLA-DRA/TNFSF13B/TGFB1/HLA-DQA1/CD40/IL15	4.60615040734209
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	33/587	275/9376	1.91672913117547	NCF1/RAC1/HSPA1A/CYBA/NCF2/CYBB/IL1B/TNF/EGR1/CSNK2B/PSMD4/PSMB3/VDAC2/BAX/SDHD/COX7A2L/NDUFB5/PPIF/HSPA6/NCF4/PSMA5/NDUFS2/CCL5/STIP1/PSMA2/TUBA1A/HSPA1B/APAF1/PSMD9/NOTCH1/ADRM1/PRKCD/PSMC5	3.98747321315724
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	30/587	250/9376	1.91672913117547	HLA-C/HLA-A/HLA-B/CXCR4/HLA-F/ARPC3/HSPA1A/HLA-E/SMAP2/CHMP5/RAB8A/RHOA/CHMP1B/RUFY1/CYTH1/CHMP2A/ARF6/SNX2/CHMP4A/CLTB/IL2RG/CHMP2B/ARFGAP3/HSPA6/ARF5/HSPA1B/ARPC5/SNF8/VPS28/CAPZA2	3.79669544261123
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/587	72/9376	2.88396744274087	NFKBIA/ISG15/IRF7/CXCL8/IFIH1/TNF/CXCL10/NFKB1/TANK/ZNFX1/ADAR/TRADD/RELA	4.14705454285269
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	34/587	298/9376	1.82239346923842	CCL3L3/CCL4L2/CCL3/CCL4/CXCR4/IFNGR2/TNFSF10/CXCL8/IL1B/TNF/CXCL10/TNFSF13B/CXCL3/TGFB1/CXCL2/EBI3/CSH1/TNFRSF1B/IL2RG/CSH2/RELT/CD40/CXCL16/INHBA/CXCL9/TNFRSF14/IL15/CXCL11/CCL5/LTB/IL3RA/TNFSF12/PPBP/TNFRSF10A	3.72844423838746
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/587	142/9376	2.24968207884445	JUN/KLF2/FOS/NCF1/DUSP1/VEGFA/RAC1/CYBA/NCF2/IL1B/TNF/GSTO1/RHOA/CALM1/SUMO2/ACTG1/SUMO1/NFKB1/ICAM1/RELA	3.87778508152744
Human Diseases	Immune disease	hsa05310	Asthma	8/587	32/9376	3.99318568994889	HLA-DQA2/HLA-DPB1/HLA-DPA1/TNF/HLA-DRA/FCER1G/HLA-DQA1/CD40	4.38305773255152
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/587	105/9376	2.43394175387361	JUN/BNIP3L/UBC/RRAS/GABARAP/CSNK2B/GABARAPL2/FKBP8/TAX1BP1/CITED2/CALCOCO2/MAP1LC3B/USP15/GABARAPL1/RELA/OPTN	3.81854423907637
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/587	77/9376	2.69669682957588	GADD45B/VEGFA/RAC1/STAT1/RALA/TGFB1/STAT3/BAX/RALB/NFKB1/JAK1/CDKN1A/RELA	3.86337125034974
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/587	50/9376	3.19454855195911	CXCL8/IL1B/TNF/HBA2/TGFB1/HBA1/TLR2/MYD88/CD40/ICAM1	4.02084606479419
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/587	205/9376	1.94789545851166	HLA-C/NFKBIA/HLA-A/HLA-B/JUN/HLA-F/GRB2/IRF7/RAC1/YWHAH/HLA-E/PKM/RHOA/EIF2AK2/STAT3/BAX/NFKB1/SP100/LYN/JAK1/POLB/CDKN1A/TRADD/NFKB2/RELA	3.54620618479268
Genetic Information Processing	Transcription	hsa03040	Spliceosome	28/587	243/9376	1.84048064721924	HSPA1A/SRSF5/HNRNPA1/SRSF3/PQBP1/SF3B5/LSM6/SRSF9/HNRNPM/BUD31/SF3B6/SYF2/CCDC12/HSPA6/HNRNPU/ACIN1/ALYREF/ZMAT2/CDC5L/BCAS2/EIF4A3/SNRPB/SRSF4/HSPA1B/CWC15/SF3B2/SNRNP70/MAGOH	3.43051310285044
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/587	100/9376	2.39591141396934	HLA-DQA2/HLA-DPB1/HLA-DPA1/IL1B/TNF/HLA-DRA/CD14/CD9/CD37/CD38/HLA-DQA1/CD1D/FCGR1A/IL3RA/CD44	3.62670678646191
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/587	90/9376	2.48464887374598	NFKBIA/JUN/FOS/STAT1/IFNGR2/PTPN6/CSNK2B/STAT3/JAK2/TLR2/MYD88/NFKB1/JAK1/RELA	3.65734243337278
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/587	71/9376	2.69961849461334	NFKBIA/JUN/RAC1/CXCL8/ATP6V1F/CXCL3/CXCL2/NFKB1/PAK1/LYN/CCL5/RELA	3.71498778810116
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/587	67/9376	2.6223906023545	LDHA/ALDOA/GAPDH/TPI1/ALDH2/FBP1/ENO1/PGK1/PKM/HK2/ALDOC	3.44410406060755
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	37/587	368/9376	1.60595511443597	RAC1/CASP1/BID/PFN1/TNF/RAB8A/GPX1/HNRNPA1/SRSF3/NUP214/PSMD4/PSMB3/MAP1LC3B/TNFRSF1B/BAX/SDHD/ACTG1/CHMP2B/COX7A2L/NDUFB5/PSMA5/HNRNPA2B1/ALYREF/NDUFS2/TANK/NRBF2/DERL1/PSMA2/TUBA1A/NUP93/APAF1/ANG/PSMD9/ADRM1/PSMC5/ATG101/OPTN	3.0646799887596
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/587	133/9376	2.04162877380846	KLF2/SOD2/GADD45B/GRB2/TNFSF10/PLK3/GABARAP/S1PR4/GABARAPL2/TGFB1/STAT3/HOMER3/BCL6/SGK1/CDKN1A/CDKN2D/GABARAPL1	3.12656360997432
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/587	300/9376	1.65051675184554	JUN/FOS/GADD45B/JUND/DUSP1/GRB2/VEGFA/RAC1/HSPA1A/RRAS/IL1B/DUSP2/TNF/NR4A1/CD14/MAP3K8/TGFB1/RELB/RAP1B/MYD88/IRAK1/NFKB1/HSPA6/PAK1/LAMTOR3/HSPA1B/RAP1A/TRADD/NFKB2/MAX/RELA	2.95942150379601
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/587	174/9376	1.83594744365466	PPP1R15A/HSPA1A/UBXN1/ERO1A/FBXO6/STUB1/BAX/RBX1/CUL1/UBE2D1/UBE2D2/DNAJC1/HSPA6/DNAJA2/DERL1/HSPA1B/DNAJA1/DNAJB1/OS9/RNF5	2.87638781484462
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/587	201/9376	1.74826040156966	CEBPB/GADD45B/LMO2/BCL2A1/NFKBIZ/CXCL8/LYL1/CD86/CD14/SPI1/BIRC3/BAX/CD40/BCL6/NFKB1/RARA/NUPR1/FCGR1A/CDKN1A/MAX/RELA/CDK9	2.77129470206554
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/587	142/9376	1.91222976701778	UBC/UBE2L6/SOCS3/UBE2B/BIRC3/UBE2E1/UBE2R2/STUB1/RBX1/CUL1/UBE2D1/UBE2D2/CDC26/ANAPC10/ANAPC16/UBE2I/UBE2M	2.83066472773442
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/587	87/9376	2.2031369323856	JUN/FOS/GADD45B/GRB2/RAC1/RALA/RHOA/TGFB1/BAX/RALB/CDKN1A/BBC3	2.91356800874617
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/587	120/9376	1.99659284497445	NFKBIA/JUN/GRB2/RAC1/RHOA/CALM1/RAP1B/RIPK2/BAX/IRAK1/ARHGDIB/NFKB1/RAP1A/RELA/PRKCD	2.83943330113767
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	19/587	169/9376	1.7957521445924	UBC/DDIT4/RRAS/RAB8A/ATG3/GABARAP/GABARAPL2/TAX1BP1/CALCOCO2/MAP1LC3B/IGBP1/TANK/NRBF2/GABARAPL1/PRKCD/RHEB/ATG101/OPTN/ATG16L2	2.69772113919694
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/587	160/9376	1.796933560477	HLA-C/HLA-A/HLA-B/HLA-DQA2/HLA-F/VCAN/HLA-DPB1/HLA-E/HLA-DPA1/CD86/HLA-DRA/ICAM3/ICAM2/HLA-DQA1/CD58/CD40/SELL/ICAM1	2.62751879392604
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/587	70/9376	2.28182039425651	JUN/GRB2/VEGFA/RAC1/TGFB1/RAP1B/RBX1/PAK1/CDKN1A/RAP1A	2.78182387151408
Genetic Information Processing	Translation	hsa03010	Ribosome	23/587	222/9376	1.65483370934819	RPL36A/RPS10/RPS9/RPL3/RPL7A/RPL36AL/RPL24/RPS3A/RPL8/RPS4X/MRPL28/RPS27L/RPS3/RPL9/RPS26/RPL26/RPL19/RPL10/RPL10A/RPL17/DAP3/MRPL18/MRPL14	2.55174350233823
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/587	103/9376	2.0159772415276	CXCL8/IL1B/TNF/CD14/SERPINB9/CXCL3/TGFB1/CXCL2/GNA15/TLR2/NFKB1/CD1D/RELA	2.67933747623153
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/587	32/9376	2.99488926746167	ATG3/GABARAP/GABARAPL2/IGBP1/GABARAPL1/ATG101	2.92120694639603
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/587	42/9376	2.66212379329926	FTH1/CYBB/SAT2/GPX4/SAT1/MAP1LC3B/VDAC2	2.78990278219149
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/587	73/9376	2.18804695339665	MX1/APOBEC3A/CXCR4/MX2/APOBEC3G/BST2/CHMP4A/NELFE/SUPT4H1/CDK9	2.63341000436205
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/587	33/9376	2.90413504723556	VAMP5/STX11/STX6/STX4/VAMP2/STX18	2.83169516174664
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/587	333/9376	1.48695202868968	HLA-C/HLA-A/HLA-B/ISG15/MX1/HLA-F/MX2/GRB2/VEGFA/STAT1/HLA-E/OASL/IRF1/TNF/PKM/ATP6V1F/EIF2AK2/BAX/LFNG/STAT2/PTGS2/NFKB1/JAK1/HES4/CDKN1A/TRADD/PPP2R3C/RELA/NOTCH1/RHEB/PTGER4	2.33822870301164
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/587	157/9376	1.72953265551927	HLA-C/HLA-A/HLA-B/GADD45B/HLA-F/HLA-E/CXCL8/RRAS/CALM1/TGFB1/RASSF5/VDAC2/NFKB1/NBN/CDKN1A/RELA/RHEB	2.38225151584288
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/587	170/9376	1.6912315863313	JUN/ARPC3/RAC1/VASP/RAB8A/RHOA/WAS/MSN/MYL12A/HCLS1/ACTG1/YBX3/CD1D/MYL6/MYL12B/TUBA1A/ARPC5/RAP1A	2.35043100487374
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/587	35/9376	2.73818447310781	ALDOA/TPI1/FBP1/HK2/PFKFB3/ALDOC	2.66236845461765
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/587	99/9376	1.93609003149037	HLA-DQA2/HLA-DPB1/HLA-DPA1/HLA-DRA/DEFB1/FCGR2A/FCGR3A/FCGR2B/HLA-DQA1/CFD/FCGR1A/ICAM1	2.41972714219143
NA	NA	hsa04517	IgSF CAM signaling	28/587	299/9376	1.49577524171999	CD48/ARPC3/GRB2/RAC1/PTPN6/CD86/RHOA/ICAM3/MSN/ICAM2/ARF6/SLAMF7/RAP1B/MYL12A/DOK2/VAV1/ACTG1/DYNLL1/MYL6/MYL12B/PAK1/DOK1/LYN/ICAM1/TUBA1A/ARPC5/RAP1A/CRTAM	2.25156359468012
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/587	125/9376	1.7889471890971	RAC1/BID/TNF/RHOA/S1PR4/FCER1G/GNAI2/BAX/SPTLC2/NFKB1/SPHK1/TRADD/PPP2R3C/RELA	2.29479320791559
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/587	68/9376	2.11403948291412	GRB2/BCL2A1/CD14/SPI1/STAT3/NFKB1/RARA/FCGR1A/RELA	2.38265854452301
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/587	37/9376	2.59017450158847	IL1B/TNF/HBA2/HBA1/MYD88/ICAM1	2.50455409437699
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/587	70/9376	2.05363835483086	NFKBIA/SOCS3/TNF/STAT3/JAK2/TNFRSF1B/NFKB1/TRADD/RELA	2.2866201384722
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/587	93/9376	1.88924914363173	RAC1/PTPN6/RHOA/WAS/CSNK2B/RAP1B/MYL12A/ACTG1/MYL12B/RAP1A/CTNNA1	2.22718201675249
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/587	71/9376	2.02471387096	FOS/GRB2/STAT1/IRF1/SOCS3/STAT3/JAK2/NFKB1/RELA	2.23979647725611
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/587	168/9376	1.61628944593169	GRB2/STAT1/IFNGR2/SOCS3/PTPN6/MCL1/STAT3/JAK2/CSH1/PTPN2/IL2RG/CSH2/STAT2/IL15/JAK1/CDKN1A/IL3RA	2.08301152365586
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/587	157/9376	1.62779544048872	JUN/FOS/RAC1/CXCL8/BID/IL1B/SOCS3/TNF/TGFB1/BAX/SDHD/COX7A2L/NDUFB5/NFKB1/NDUFS2/RELA	2.05003385171154
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/587	122/9376	1.7020135727651	NFKBIA/JUN/FOS/GRB2/TNF/PTPN6/RHOA/MAP3K8/VAV1/NFKB1/PAK1/PPP2R3C/RELA	2.01695232673547
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/587	75/9376	1.91672913117547	ALDOA/GAPDH/TPI1/ENO1/TKT/PGK1/PKM/ALDOC/SDSL	2.05987941872179
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/587	32/9376	2.49574105621806	BID/BIRC3/BAX/APAF1/BBC3	2.19028155331829
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/587	204/9376	1.48765741390253	GRB2/VEGFA/RAC1/RRAS/TNF/PTPN6/RHOA/HPSE/TGFB1/PLAUR/MSN/STAT3/TLR2/HCLS1/VAV1/ACTG1/PAK1/CDKN1A/CD44	1.81983849953435
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/587	44/9376	2.17810128542667	TAF7/TAF9/GTF2F2/CCNH/TAF10/GTF2F1	2.02421463104673
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	39/587	480/9376	1.29778534923339	UBC/UBE2L6/RAC1/CYBB/BID/IL1B/TNF/RAB8A/GPX1/CSNK2B/CALM1/SNCA/PSMD4/PSMB3/MAP1LC3B/VDAC2/TNFRSF1B/BAX/SDHD/CHMP2B/COX7A2L/NDUFB5/PPIF/PTGS2/NFKB1/PSMA5/NDUFS2/TANK/NRBF2/DERL1/PSMA2/TUBA1A/APAF1/RELA/PSMD9/ADRM1/PSMC5/ATG101/OPTN	1.73085830087102
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/587	116/9376	1.6523526992892	ALDOA/GAPDH/TPI1/FBP1/ENO1/TKT/PGK1/PKM/HK2/SDHD/ALDOC/SDSL	1.8270099880576
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/587	195/9376	1.47440702398113	NCF1/RAC1/CYBA/NCF2/CYBB/CASP1/FCGR2A/FCGR3A/TLR2/VDAC2/ACTG1/PPIF/NFKB1/NCF4/CASP4/FCGR1A/GSDMD/RELA	1.73004890151847
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/587	143/9376	1.56376502543453	HLA-DQA2/HLA-DPB1/HLA-DPA1/TNF/CD86/HLA-DRA/SSB/FCGR2A/FCGR3A/HLA-DQA1/CD40/TRIM21/FCGR1A/SNRPB	1.7556166354383
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/587	93/9376	1.71749922148339	NFKBIA/GADD45B/BIRC3/BAX/PTGS2/NFKB1/CDKN1A/APAF1/MAX/RELA	1.79702322410502
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/587	144/9376	1.55290554609124	NFKBIA/ALDH2/CXCL8/IL1B/TNF/CD14/CXCL3/CXCL2/MYD88/IRAK1/NFKB1/TRADD/RELA/LPIN2	1.7279025717246
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/587	108/9376	1.62685342923844	EEF1A1/SAP18/SUMO2/NUP214/SUMO1/ACIN1/ALYREF/EIF4A3/NUP93/UBE2I/MAGOH	1.69324510122762
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	20/587	227/9376	1.4072901109952	NFKBIA/JUN/FOS/SOD2/NCF1/GRB2/VEGFA/RAC1/CYBA/NCF2/GSTO1/VDAC2/SDHD/COX7A2L/NDUFB5/PPIF/NFKB1/NDUFS2/RELA/PRKCD	1.60533227393943
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/587	85/9376	1.6912315863313	TYMP/UPP1/CMPK2/HPRT1/GUK1/GMPR2/NT5C3A/NUDT16/AK6	1.65438568937686
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/587	50/9376	1.91672913117547	LAP3/ALDH2/P4HA1/SAT2/SAT1/CNDP2	1.67962869460258
Organismal Systems	Immune system	hsa04611	Platelet activation	12/587	126/9376	1.52121359617101	VASP/APBB1IP/RHOA/FCGR2A/FCER1G/GNAI2/RAP1B/MYL12A/ACTG1/MYL12B/LYN/RAP1A	1.52217680129208
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/587	75/9376	1.70375922771153	BID/GSTO1/BIRC3/BAX/ERCC1/CDKN1A/APAF1/BBC3	1.58133858693865
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/587	75/9376	1.70375922771153	GADD45B/BID/SIVA1/BAX/CDKN1A/APAF1/BBC3/TNFRSF10A	1.58133858693865
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/587	77/9376	1.65950574127746	NFKBIA/GADD45B/GRB2/TGFB1/BAX/NFKB1/CDKN1A/RELA	1.50169168461807
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/587	130/9376	1.47440702398113	NFKBIA/JUN/FOS/GRB2/VEGFA/GNAI2/TGFB1/GNA15/GNG5/NFKB1/RELA/ACTA2	1.40760499299446
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/587	78/9376	1.6382300266457	ARPC3/RAC1/RHOA/HCLS1/CLTB/ACTG1/ARPC5/CTNNA1	1.46273185513571
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/587	30/9376	2.12969903463941	IL1B/TNF/NFKB1/RELA	1.60156825963789
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	22/587	268/9376	1.31119530117725	UBC/DUSP1/UBE2L6/CALM1/GNAI2/SNCA/PSMD4/PSMB3/VDAC2/BAX/SDHD/COX7A2L/NDUFB5/PPIF/PSMA5/NDUFS2/PSMA2/TUBA1A/APAF1/PSMD9/ADRM1/PSMC5	1.33574597274944
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/587	31/9376	2.06099906578007	ALDOA/FBP1/TKT/ALDOC	1.52911853347617
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/587	31/9376	2.06099906578007	SEC11A/SRP9/SRP19/SRP54	1.52911853347617
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	30/587	388/9376	1.23500588348935	GAPDH/CYBB/BID/IL1B/TNF/CSNK2B/CALM1/EIF2AK2/SNCA/PSMD4/PSMB3/VDAC2/SDHD/COX7A2L/NDUFB5/PPIF/PTGS2/NFKB1/PSMA5/NDUFS2/NRBF2/PSMA2/TUBA1A/PSENEN/APAF1/RELA/PSMD9/ADRM1/PSMC5/ATG101	1.22179409743741
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/587	44/9376	1.81508440452222	STX4/DYNC1LI1/ARHGDIB/DYNLL1/VAMP2	1.40047871739174
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/587	69/9376	1.62042317852999	GRB2/RAC1/TNF/FCER1G/VAV1/ALOX5/LYN	1.33672681247391
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/587	205/9376	1.32456891178793	GAPDH/NCF1/RAC1/CYBA/NCF2/CYBB/TGFB1/VDAC2/SDHD/COX7A2L/NDUFB5/PPIF/NFKB1/NCF4/NDUFS2/RELA/PRKCD	1.21425656388417
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/587	34/9376	1.87914620703477	RBX1/CUL1/BHLHE40/NFIL3	1.32713648992713
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/587	47/9376	1.69922795316974	SOCS3/TNF/PKM/HK2/PRKCD	1.24189569285419
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/587	12/9376	2.66212379329926	ASGR1/FCGR2B	1.48887502027309
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/587	226/9376	1.27216535255009	NFKBIA/JUN/FOS/RAC1/RRAS/RHOA/CALM1/GNAI2/RAP1B/VAV1/ATP1B3/FFAR2/NFKB1/PAK1/CRH/RAP1A/HCAR3/RELA	1.07031464174038
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/587	212/9376	1.28083314583266	VEGFA/RAC1/RRAS/VASP/PFN1/APBB1IP/RALA/RHOA/CALM1/GNAI2/RASSF5/RAP1B/VAV1/ACTG1/RALB/RAP1A/SIPA1L1	1.0688301883809
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/587	115/9376	1.3889341530257	FOS/JUND/NACA/MAFB/EGR1/RHOA/GNAI2/NR4A2/SGK1/CDKN1A	1.08450364419003
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/587	157/9376	1.32258379539709	CEBPB/RAC1/CASP1/DUSP2/PTPN6/TGFB1/JAK2/NR1H2/PTGS2/SPHK1/ALOX5/SGK1/PTGER4	1.05338085931749
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/587	49/9376	1.62987171018322	JUN/FOSB/GNAI2/NFKB1/RELA	1.14238925940792
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/587	37/9376	1.72678300105898	GADD45B/BAX/CDKN1A/TPM3	1.14469659726499
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/587	38/9376	1.68134134313638	CD38/NAMPT/SIRT7/NAPRT	1.08758838889642
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/587	38/9376	1.68134134313638	TAP1/TAP2/IL2RG/CD40	1.08758838889642
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/587	308/9376	1.19276975154318	SOD2/GPX1/PSMD4/PSMB3/VDAC2/BAX/SDHD/CLTB/COX7A2L/NDUFB5/PPIF/PSMA5/NDUFS2/NRBF2/PSMA2/TUBA1A/POLR2E/APAF1/PSMD9/ADRM1/BBC3/PSMC5/ATG101	0.888982980917412
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/587	149/9376	1.28639539005065	GRB2/CXCL8/RRAS/RALA/RHOA/FCER1G/CYTH1/ARF6/RALB/SPHK1/AGPAT2/RHEB	0.910675920887402
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/587	122/9376	1.30924120981931	FOS/JUNB/GRB2/STAT1/SOCS3/GNAI2/STAT3/JAK2/CSH1/CSH2	0.888479656042563
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/587	80/9376	1.39761499148211	GRB2/VEGFA/STAT3/JAK2/BAX/JAK1/EIF4E2	0.922984999845035
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/587	110/9376	1.306860771256	EMP3/TNF/SKIL/RHOA/TGFB1/RBX1/CUL1/INHBA/TGIF1	0.836616688533948
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/587	139/9376	1.26403000257375	JUN/FOS/GRB2/HSPA1A/CALM1/GNAI2/HSPA6/RARA/FKBP5/HSPA1B/PRKCD	0.810457349326564
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/587	41/9376	1.55831636680932	TYMP/VEGFA/CXCL8/CDKN1A	0.925870150656247
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/587	144/9376	1.22014007192883	PSMD4/PSMB3/VDAC2/PPIF/PSMA5/NRBF2/PSMA2/PSMD9/ADRM1/PSMC5/ATG101	0.687966686379909
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/587	73/9376	1.31282817203799	GADD45B/GRB2/RASSF5/STAT3/BAX/CDKN1A	0.693411010007529
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/587	102/9376	1.25276413802318	RAC1/RAB8A/RHOA/CD38/RAP1B/ATP1B3/RAP1A/KCNQ1	0.663310624035281
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/587	59/9376	1.35362226777929	GADD45B/GRB2/BAX/CDKN1A/CTNNA1	0.70414568068971
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/587	90/9376	1.24232443687299	SOD2/BAX/NFKB1/EIF4E2/RELA/RHEB/ATG101	0.596951549481581
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/587	19/9376	1.68134134313638	HPSE/IDS	0.768259934030778
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/587	63/9376	1.26767799680917	POLD4/RBX1/ERCC1/CCNH/POLR2E	0.550900419890418
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/587	154/9376	1.14091019712825	JUN/FOS/RHOA/CALM1/GNAI2/CD38/RGS2/ACTG1/PTGS2/MYL6/CDKN1A	0.455643501385654
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/587	109/9376	1.17231139521435	NFKBIA/SOCS3/TNF/STAT3/NR1H2/NFKB1/RELA/PRKCD	0.467619510556108
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/587	232/9376	1.1015684661928	TMSB4X/CXCR4/ARPC3/RAC1/RRAS/PFN1/BRK1/RHOA/MSN/MYL12A/CFL1/VAV1/ACTG1/MYL12B/PAK1/ARPC5	0.404827246395616
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/587	21/9376	1.52121359617101	ALDH2/PANK2	0.617928810064951
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/587	203/9376	1.1015684661928	JUN/GRB2/VEGFA/RAC1/VASP/RHOA/RAP1B/BIRC3/MYL12A/VAV1/ACTG1/MYL12B/PAK1/RAP1A	0.378082149099543
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/587	51/9376	1.25276413802318	ERO1A/ATP6V1F/ACTG1/KCNQ1	0.46774707569565
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/587	158/9376	1.11202639466931	GADD45B/YWHAH/TGFB1/RBX1/CUL1/CDC26/CCNH/CDKN1A/CDKN2D/ANAPC10/ANAPC16	0.366999529539355
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/587	158/9376	1.11202639466931	GRB2/DDIT4/TNF/RHOA/ATP6V1F/LAMTOR3/SGK1/EIF4E2/FNIP1/LPIN2/RHEB	0.366999529539355
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/587	22/9376	1.45206752361778	ALDH2/CNDP2	0.548593835028885
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/587	83/9376	1.15465610311775	CSNK2B/UBE2D1/UBE2D2/RNF2/PHC2/MAX	0.365732114782615
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/587	238/9376	1.0737978325913	GRB2/VEGFA/RAC1/RRAS/RALA/RHOA/CALM1/RASSF5/ARF6/RAP1B/GNG5/RALB/NFKB1/PAK1/RAP1A/RELA	0.298017292790098
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/587	99/9376	1.12938585170272	JUN/FOS/GRB2/RAC1/GPCPD1/WAS/RHEB	0.33445336094666
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/587	194/9376	1.07033843235744	DYNLT1/MYO1G/MYL12A/DYNC1LI1/ACTG1/DYNLL1/MYL6/MYL12B/TUBA1A/DYNLT3/TPM3/CAPZA2/ACTA2	0.255834943179366
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/587	71/9376	1.12484103942222	LDHA/PKM/HK2/SCO2/SLC16A3	0.2728747294627
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/587	103/9376	1.0855262069764	SAP18/ACIN1/ALYREF/EIF4A3/PCF11/PPP2R3C/MAGOH	0.225549906223538
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/587	217/9376	1.03049953289004	JUN/FOS/KLF4/GRB2/VEGFA/GSTO1/GNAI2/PTGES3/STAT3/JAK2/BCL6/AIP/NFKB1/RELA	0.117471897003024
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/587	42/9376	1.14091019712825	ALDH2/IL4I1/KYNU	0.236520139229178
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	23/587	362/9376	1.01484277203121	GRB2/VEGFA/RAC1/YWHAH/DDIT4/NR4A1/MCL1/JAK2/CSH1/TLR2/GNG5/IL2RG/CSH2/NFKB1/JAK1/SGK1/CDKN1A/EIF4E2/IL3RA/PKN1/PPP2R3C/RELA/RHEB	0.0744295652420975
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/587	59/9376	1.08289781422343	TYMP/UPP1/CMPK2/NT5C3A	0.165069180146988
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/587	59/9376	1.08289781422343	LAP3/GPX1/GSTO1/GPX4	0.165069180146988
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/587	140/9376	1.02681917741543	KLF2/RRAS/EGR1/CALM1/GNAI2/GNG5/MAP1LC3B/SPHK1/ACTA2	0.0826232864384093
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/587	76/9376	1.05083833946023	UBC/PLIN2/OLR1/ACAA1/GK	0.114998356888935
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/587	76/9376	1.05083833946023	CALM1/GNAI2/ACTG1/ATP1B3/KCNQ1	0.114998356888935
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/587	76/9376	1.05083833946023	GADD45B/GRB2/CALM1/BAX/CDKN1A	0.114998356888935
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/587	60/9376	1.0648495173197	VEGFA/RAC1/PTGS2/SPHK1	0.13022746592964
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/587	44/9376	1.08905064271333	POLD4/POLB/MPG	0.15300689008175
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/587	93/9376	1.03049953289004	LYZ/CALM1/CD38/ATP1B3/VAMP2/CST3	0.0763880535151489
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/587	45/9376	1.0648495173197	TAP1/DEFB1/TAP2	0.112689607621176
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/587	78/9376	1.02389376665356	BTG1/ENO1/LSM6/NUDT16/EXOSC1	0.0547610926534277
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/587	62/9376	1.03049953289004	SOD2/HSPA1A/HSPA6/HSPA1B	0.0622667032851506
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/587	62/9376	1.03049953289004	LFNG/DTX3L/PSENEN/NOTCH1	0.0622667032851506
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/587	63/9376	1.01414239744734	GPX4/PTGES3/PTGS2/ALOX5	0.0291060631985744
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/587	13/9376	1.22867251998427	XRCC6	0.213212714209247
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/587	47/9376	1.01953677190184	LDHA/ALDH2/PKM	0.0346991746642688
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/587	48/9376	0.998296422487223	ALDH2/IL4I1/ACAA1	-0.0030578994816968
NA	NA	hsa03272	Virion - Hepatitis viruses	3/587	48/9376	0.998296422487223	CHMP1B/CD9/CHMP4A	-0.0030578994816968
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/587	48/9376	0.998296422487223	HK2/ATP1B3/SLC2A5	-0.0030578994816968
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/587	31/9376	1.03049953289004	ALDH2/CNDP2	0.0439561188211153
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/587	65/9376	0.98293801598742	ALDH2/GK/AGPAT2/LPIN2	-0.0356716339071479
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/587	82/9376	0.973947729255828	TYMP/UPP1/GSTO1/HPRT1/CES1	-0.0612330837706793
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/587	99/9376	0.968045015745186	JUN/FOS/GRB2/BAX/CDKN1A/NOTCH1	-0.082601395302294
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/587	184/9376	0.95489223020517	CXCR4/RAC1/RRAS/RHOA/GNAI2/SEMA4D/MYL12A/CFL1/SEMA4A/MYL12B/PAK1	-0.159694594375055
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/587	15/9376	1.0648495173197	ST6GALNAC4	0.0649570377467267
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/587	154/9376	0.933471979468572	ALDH2/GCH1/KYNU/CMPK2/MTHFD1L/PANK2/PDXK/AK6/NAPRT	-0.215123254618726
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/587	69/9376	0.925956102017135	JUN/FOS/FOSB/CALM1	-0.159530570679664
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/587	34/9376	0.939573103517386	POLR1D/POLR2E	-0.0912188878862489
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/587	138/9376	0.925956102017135	GRB2/FBP1/SOCS3/HK2/CALM1/FLOT1/EIF4E2/RHEB	-0.226451287697529
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/587	16/9376	0.998296422487223	IL4I1	-0.00176245859210839
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/587	88/9376	0.907542202261112	SERPINA1/PLAUR/SERPING1/PROC/CFD	-0.225194995004537
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/587	89/9376	0.89734509886492	GABARAP/GABARAPL2/GNAI2/GNG5/GABARAPL1	-0.251461745708994
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/587	54/9376	0.887374597766421	LDHA/IL4I1/SDSL	-0.214493256196457
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/587	37/9376	0.86339150052949	HK2/NANS	-0.21516089984702
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/587	18/9376	0.887374597766421	TCN2	-0.12359930927889
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/587	56/9376	0.855682647846191	CUL1/CSNK1G2/SPOP	-0.279923632997713
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/587	38/9376	0.840670671568188	HK2/RENBP	-0.254328802088294
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/587	38/9376	0.840670671568188	ATP1B3/SGK1	-0.254328802088294
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/587	75/9376	0.851879613855764	GPX1/ASGR1/ATP1B3/ASGR2	-0.332824740193879
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/587	93/9376	0.858749610741697	JUN/GRB2/EGR1/CALM1/PRKCD	-0.35377073913232
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/587	39/9376	0.81911501332285	MTHFD1L/MTHFS	-0.292527098095941
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/587	148/9376	0.86339150052949	JUN/FOS/GADD45B/GRB2/BAX/CDKN1A/NFKB2/NOTCH1	-0.432902149630447
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/587	20/9376	0.798637137989779	NANS	-0.232961537096981
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/587	60/9376	0.798637137989779	GNAI2/LYN/CRH	-0.404366544821805
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/587	41/9376	0.779158183404662	POLD4/NBN	-0.36622756945285
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/587	61/9376	0.785544725891585	FTH1/MT2A/ATP1B3	-0.434255348173383
NA	NA	hsa04518	Integrin signaling	8/587	154/9376	0.829752870638731	VEGFA/RAC1/TGFB1/ICAM3/LIMS1/ICAM2/ACTG1/ICAM1	-0.550506632620916
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/587	43/9376	0.742918267897468	ALDH2/ACAA1	-0.436646284271393
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/587	63/9376	0.760606798085503	GADD45B/BAX/CDKN1A	-0.492688293493269
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/587	138/9376	0.810211589264993	YWHAH/CALM1/RBX1/CUL1/CDC26/ANAPC10/ANAPC16	-0.580437161897602
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/587	83/9376	0.769770735411835	SOD2/ACAA1/PEX2/PHYH	-0.544448192636575
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/587	23/9376	0.694467076512851	POLD4	-0.379124126793958
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/587	23/9376	0.694467076512851	ATP1B3	-0.379124126793958
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/587	104/9376	0.767920324990172	GPCPD1/LPCAT2/LPCAT1/AGPAT2/LPIN2	-0.615038103370488
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/587	46/9376	0.694467076512851	FTH1/BLVRA	-0.536822939946261
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/587	86/9376	0.742918267897468	JUN/GRB2/PAK1/CDKN1A	-0.61893856338132
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/587	67/9376	0.715197437005772	CALM1/RAP1B/RAP1A	-0.604595257305079
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/587	106/9376	0.753431262254508	NFKBIA/GRB2/NFKB1/CDKN1A/RELA	-0.659760079740729
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/587	144/9376	0.776452773045618	KLF4/GRB2/SKIL/STAT3/JAK2/INHBA/JAK1	-0.698614494079684
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/587	107/9376	0.746389848588578	LDHA/FBP1/PKM/CALM1/PPP4C	-0.681831462814445
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/587	26/9376	0.614336259992137	ACAA1	-0.508890840010476
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/587	26/9376	0.614336259992137	TCN2	-0.508890840010476
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/587	69/9376	0.694467076512851	CALM1/GNAI2/PTGER4	-0.658283031730857
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/587	70/9376	0.684546118276953	GSTO1/PTGS2/SULT1A1	-0.684602259779107
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/587	166/9376	0.769770735411835	VASP/RHOA/CALM1/GNAI2/VDAC2/RGS2/ATP1B3/PPIF	-0.773427681590509
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/587	27/9376	0.591583065177614	ACAA1	-0.549209448797593
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/587	28/9376	0.570455098564127	GCH1	-0.588251697202472
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/587	28/9376	0.570455098564127	ATP6V1F	-0.588251697202472
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/587	51/9376	0.626382069011591	LPCAT2/LPCAT1	-0.691390384783381
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/587	73/9376	0.656414086018996	GADD45B/BAX/CDKN1A	-0.761588235758362
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/587	52/9376	0.614336259992137	PTGS2/ALOX5	-0.720683044477578
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/587	29/9376	0.550784233096399	PAK1	-0.626113150062239
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/587	29/9376	0.550784233096399	CALM1	-0.626113150062239
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/587	53/9376	0.602745009803606	CLTB/ATP1B3	-0.749487528669406
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/587	115/9376	0.694467076512851	FOS/GNAI2/JAK2/GNG5/KCNQ1	-0.851947730391138
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/587	115/9376	0.694467076512851	DUSP1/GNAI2/GNG5/PTGS2/ALOX5	-0.851947730391138
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/587	30/9376	0.532424758659852	SDHD	-0.662878910719733
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/587	155/9376	0.721349673023026	NR4A1/GNAI2/RAP1B/AIP/CRH/CDKN1A/RAP1A	-0.904006080592299
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/587	117/9376	0.682595844435708	MBD2/BAZ1A/ACTG1/BCL7C/EPC2	-0.892808782624415
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/587	97/9376	0.658669804527652	FOS/CALM1/GNAI2/GNG5	-0.873262771266507
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/587	31/9376	0.515249766445018	ALDH2	-0.698625088506412
NA	NA	hsa04981	Folate transport and metabolism	1/587	31/9376	0.515249766445018	MTHFS	-0.698625088506412
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/587	55/9376	0.580827009447112	SPTLC2/SPHK1	-0.805709229226804
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/587	98/9376	0.651948684073289	NR4A1/CALM1/NR4A2/ATP1B3	-0.895084610961269
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/587	138/9376	0.694467076512851	ATP6V1F/SDHD/COX7A2L/NDUFB5/PPA1/NDUFS2	-0.934423036097675
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/587	32/9376	0.499148211243612	HK2	-0.733420018992684
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/587	32/9376	0.499148211243612	LDHA	-0.733420018992684
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/587	99/9376	0.645363343830124	IL1B/CALM1/PRKCD/PTGER4	-0.916710907800202
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/587	99/9376	0.645363343830124	TNF/TGFB1/ACTG1/TPM3	-0.916710907800202
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/587	79/9376	0.606559851637807	ATP6V1F/CLTB/VAMP2	-0.907519074466678
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/587	122/9376	0.654620604909654	FBP1/RAB8A/PPP2R3C/PFKFB3/RHEB	-0.992308128445622
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/587	122/9376	0.654620604909654	STAT1/ACTG1/ATP1B3/NOTCH1/RHEB	-0.992308128445622
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/587	59/9376	0.541448907111714	GNAI2/PTGS2	-0.913083820938457
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/587	105/9376	0.608485438468403	TNF/TGFB1/ACTG1/TPM3	-1.04259163206065
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/587	36/9376	0.44368729888321	HK2	-0.86423478855833
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/587	36/9376	0.44368729888321	ST6GALNAC4	-0.86423478855833
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/587	36/9376	0.44368729888321	POLD4	-0.86423478855833
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/587	37/9376	0.431695750264745	IL4I1	-0.895089648403024
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/587	37/9376	0.431695750264745	IL4I1	-0.895089648403024
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/587	128/9376	0.623935264054514	HPRT1/GUK1/GMPR2/NUDT16/AK6	-1.10707907415609
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/587	170/9376	0.657701172462171	GADD45B/GRB2/GSTO1/TGFB1/BAX/ACTG1/CDKN1A	-1.16393665030121
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/587	150/9376	0.638909710391823	GADD45B/GRB2/TGFB1/BAX/CDKN1A/CTNNA1	-1.15209865754491
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/587	87/9376	0.550784233096399	ATP1B3/COX7A2L/TPM3	-1.08784017200732
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/587	110/9376	0.580827009447112	GNAI2/CDC26/ANAPC10/ANAPC16	-1.14282160552437
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/587	89/9376	0.538407059318952	GRB2/GNAI2/TUBA1A	-1.13071042285519
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/587	233/9376	0.685525440334574	VCAN/ENO1/FHL3/ACTG1/ATP1B3/PDLIM7/TMOD3/LMNB1/TPM3/CAPZA2	-1.25618636431709
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/587	133/9376	0.600479051120134	FOS/CALM1/GNAI2/GNG5/PPP2R3C	-1.19920617747825
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/587	154/9376	0.622314652979048	CALM1/GNAI2/ATP1B3/PPP2R3C/TPM3/KCNQ1	-1.2212733886253
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/587	134/9376	0.595997864171476	RHOA/CALM1/MYL6/PRKCD/ACTA2	-1.217273127848
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/587	41/9376	0.389579091702331	SDSL	-1.0122764295074
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/587	157/9376	0.61042329018327	YWHAH/TGFB1/BIRC3/ACTG1/BBC3/CTNNA1	-1.27214278960194
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/587	178/9376	0.628141569205444	JUN/RAC1/RHOA/CSNK2B/RBX1/CUL1/CACYBP	-1.29442200538002
NA	NA	hsa04081	Hormone signaling	9/587	219/9376	0.656414086018996	RHOA/GNAI2/GNA15/STAT3/JAK2/CSH1/GNG5/CSH2/CRH	-1.32958393078457
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/587	43/9376	0.371459133948734	AGPAT2	-1.0675594544561
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/587	44/9376	0.363016880904445	MGAT1	-1.09446493722824
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/587	250/9376	0.638909710391823	CTSH/ATP6V1F/IDS/CLTB/AP3S1/DNASE2/CTSS/SLC2A6/LAMTOR3/AP1S2	-1.49547975547438
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/587	49/9376	0.325974342036644	LFNG	-1.22247063929686
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/587	78/9376	0.409557506661425	TPI1/IMPA2	-1.35320966982885
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/587	149/9376	0.535998079187771	GNAI2/GNG5/NDUFB5/PTGS2/NDUFS2	-1.47542659975941
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/587	235/9376	0.611722063141107	GRB2/COA6/SDHD/ACTG1/COX7A2L/NDUFB5/NDUFS2/COA3/RHEB	-1.55781092972015
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/587	52/9376	0.307168129996069	VDAC2	-1.29468272380325
NA	NA	hsa04382	Cornified envelope formation	8/587	217/9376	0.588856875937164	S100A10/S100A4/S100A11/PADI2/SPTLC2/S100A6/PPP2R3C/S100A12	-1.58355745635659
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/587	54/9376	0.295791532588807	ERCC1	-1.34115363160149
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/587	323/9376	0.642865807669791	GRB2/VEGFA/DDIT4/MCL1/RHOA/STAT3/PTGS2/NFKB1/BMF/CDKN1A/CD44/NOTCH1/UBE2I	-1.68799590795534
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/587	56/9376	0.285227549282064	MGAT1	-1.38640086022644
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/587	86/9376	0.371459133948734	ATP1B3/VAMP2	-1.51324708091303
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/587	86/9376	0.371459133948734	ACTG1/CTNNA1	-1.51324708091303
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/587	57/9376	0.280223557189396	ACAA1	-1.408592453395
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/587	183/9376	0.523696483927724	CSNK2B/EIF6/UTP6/SBDS/AK6/RPP25L	-1.68157274190642
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/587	116/9376	0.413088174822299	GNAI2/HOMER3/GNG5	-1.64373316440194
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/587	91/9376	0.351049291424078	GNAI2/GNG5	-1.6075941223917
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/587	254/9376	0.565963326134489	CXCR4/VEGFA/CALM1/GNA15/CD38/VDAC2/PPIF/SPHK1/CYSLTR1	-1.81231300807686
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/587	191/9376	0.501761552663735	FOSB/GRB2/CALM1/GNAI2/GNG5/CRH	-1.79783279119012
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/587	63/9376	0.253535599361834	ALDH2	-1.53627700687696
NA	NA	hsa04519	Cadherin signaling	16/587	404/9376	0.632583871675072	NFKBIA/ARPC3/RAC1/YWHAH/RRAS/VASP/BRK1/RHOA/MYO1G/VAV1/ACTG1/NFKB1/PSENEN/ARPC5/RELA/CTNNA1	-1.95091893168297
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/587	65/9376	0.245734503996855	NR4A1	-1.57694923535147
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/587	66/9376	0.242011253936297	HSD17B11	-1.59696295380528
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/587	98/9376	0.325974342036644	CALM1/IMPA2	-1.73339380208831
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/587	68/9376	0.234893275879347	DHRS4L2	-1.63637653930316
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/587	101/9376	0.316291935837536	CALM1/GNAI2	-1.78529252523148
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/587	103/9376	0.310150344850399	ATP1B3/KCNQ1	-1.81927306878312
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/587	73/9376	0.218804695339665	GSTO1	-1.73158773293562
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/587	79/9376	0.202186617212602	GSTO1	-1.8402566839158
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/587	89/9376	0.179469019772984	CD44	-2.00995910000139
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/587	90/9376	0.177474919553284	ATP1B3	-2.02624063671087
NA	NA	hsa04082	Neuroactive ligand signaling	4/587	199/9376	0.32106015597579	GNAI2/GNG5/OGFR/P2RY13	-2.50174145581322
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/587	370/9376	0.345356600211796	S1PR4/CSH1/OGFR/CSH2/P2RY13/CRH/CYSLTR1/PTGER4	-3.32027947643181
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/587	449/9376	0.0711480746538778	CALM1/RGS2	-5.21256934176757