ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0044389 ubiquitin-like protein ligase binding 47/980 322/18639 0.145962732919255 2.7761218151857 1.99770940001718e-10 1.91380560521646e-07 GO:0031625 ubiquitin protein ligase binding 42/980 302/18639 0.139072847682119 2.64508041627247 7.99421896150983e-09 3.82923088256321e-06 GO:0005126 cytokine receptor binding 39/980 275/18639 0.141818181818182 2.69729499072356 1.58248196079909e-08 5.05339239481843e-06 GO:0042605 peptide antigen binding 14/980 45/18639 0.311111111111111 5.91714285714286 4.06599024667942e-08 9.7380466407972e-06 GO:0016504 peptidase activator activity 14/980 57/18639 0.245614035087719 4.67142857142857 1.03834974549134e-06 0.000198947811236141 GO:0003924 GTPase activity 39/980 331/18639 0.117824773413897 2.24095505271595 2.10792128176061e-06 0.000336564764654444 GO:0061134 peptidase regulator activity 30/980 226/18639 0.132743362831858 2.52469748961532 2.87525420373212e-06 0.000384825976859299 GO:0003779 actin binding 47/980 443/18639 0.106094808126411 2.01785829455936 3.83078964574047e-06 0.000384825976859299 GO:0140313 molecular sequestering activity 13/980 55/18639 0.236363636363636 4.49549165120594 4.00345124823777e-06 0.000384825976859299 GO:0042379 chemokine receptor binding 15/980 72/18639 0.208333333333333 3.96237244897959 4.01697261857305e-06 0.000384825976859299 GO:0031072 heat shock protein binding 21/980 131/18639 0.16030534351145 3.04890948745911 4.65958373969947e-06 0.000405807383875645 GO:0004857 enzyme inhibitor activity 44/980 416/18639 0.105769230769231 2.01166601255887 8.3940465781673e-06 0.000670124718490356 GO:0140297 DNA-binding transcription factor binding 49/980 488/18639 0.100409836065574 1.90973360655738 1.09286966923222e-05 0.000805360879326515 GO:0023023 MHC protein complex binding 10/980 37/18639 0.27027027027027 5.1403750689465 1.46353786254352e-05 0.000999962781149884 GO:0008009 chemokine activity 11/980 45/18639 0.244444444444444 4.64918367346939 1.56570372831402e-05 0.000999962781149884 GO:0140375 immune receptor activity 22/980 156/18639 0.141025641025641 2.68222135007849 2.28823159003581e-05 0.00137007866453394 GO:0038187 pattern recognition receptor activity 11/980 48/18639 0.229166666666667 4.35860969387755 3.01553950107737e-05 0.00166519777959071 GO:0019003 GDP binding 14/980 75/18639 0.186666666666667 3.55028571428571 3.12876409526439e-05 0.00166519777959071 GO:0032813 tumor necrosis factor receptor superfamily binding 11/980 50/18639 0.22 4.18426530612245 4.52702951521984e-05 0.00205095631135648 GO:0042288 MHC class I protein binding 7/980 20/18639 0.35 6.65678571428571 4.60609704445665e-05 0.00205095631135648 GO:0005525 GTP binding 39/980 378/18639 0.103174603174603 1.96231778425656 4.68862110161485e-05 0.00205095631135648 GO:0003735 structural constituent of ribosome 23/980 175/18639 0.131428571428571 2.49969096209913 4.70992054800027e-05 0.00205095631135648 GO:0003743 translation initiation factor activity 11/980 51/18639 0.215686274509804 4.10222088835534 5.50049657782028e-05 0.00229107640067471 GO:0019001 guanyl nucleotide binding 40/980 400/18639 0.1 1.9019387755102 7.54033330259949e-05 0.00288945572155613 GO:0032561 guanyl ribonucleotide binding 40/980 400/18639 0.1 1.9019387755102 7.54033330259949e-05 0.00288945572155613 GO:0061133 endopeptidase activator activity 7/980 22/18639 0.318181818181818 6.05162337662338 9.23749181109414e-05 0.00340366044424161 GO:0008135 translation factor activity, RNA binding 14/980 83/18639 0.168674698795181 3.20808950086059 9.98266098141754e-05 0.00352112767138443 GO:0061135 endopeptidase regulator activity 23/980 184/18639 0.125 2.37742346938776 0.000102913961167812 0.00352112767138443 GO:0005125 cytokine activity 27/980 234/18639 0.115384615384615 2.19454474097331 0.000107755139165335 0.00355963528691003 GO:0180051 translation factor activity 14/980 84/18639 0.166666666666667 3.16989795918367 0.000114085125297887 0.00364311833451251 GO:0042277 peptide binding 28/980 249/18639 0.112449799196787 2.13872633390706 0.000126558628192347 0.00391106986478285 GO:0019864 IgG binding 5/980 11/18639 0.454545454545455 8.64517625231911 0.000140818926628723 0.00421576661594739 GO:0005164 tumor necrosis factor receptor binding 8/980 31/18639 0.258064516129032 4.90822909809085 0.000151537018457863 0.00439916556614038 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/980 40/18639 0.225 4.27936224489796 0.000184903714556237 0.00520993407484927 GO:0001664 G protein-coupled receptor binding 31/980 297/18639 0.104377104377104 1.98518862090291 0.000221291329271175 0.00585080319446313 GO:0032393 MHC class I receptor activity 6/980 18/18639 0.333333333333333 6.33979591836735 0.000223653362795753 0.00585080319446313 GO:0061650 ubiquitin-like protein conjugating enzyme activity 9/980 41/18639 0.219512195121951 4.17498755599801 0.000225970478283023 0.00585080319446313 GO:0002020 protease binding 18/980 136/18639 0.132352941176471 2.51727190876351 0.000277856064877716 0.00700489763560136 GO:0019865 immunoglobulin binding 7/980 26/18639 0.269230769230769 5.1206043956044 0.00029621742094516 0.00727631510937086 GO:0017124 SH3 domain binding 16/980 115/18639 0.139130434782609 2.64617568766637 0.00033722938875207 0.00807664386061208 GO:0032396 inhibitory MHC class I receptor activity 5/980 13/18639 0.384615384615385 7.31514913657771 0.000359092307099586 0.00839049829759521 GO:0001671 ATPase activator activity 7/980 27/18639 0.259259259259259 4.93095238095238 0.00038188904908794 0.00841320259504888 GO:0023026 MHC class II protein complex binding 7/980 27/18639 0.259259259259259 4.93095238095238 0.00038188904908794 0.00841320259504888 GO:0045296 cadherin binding 33/980 334/18639 0.0988023952095808 1.87916106562385 0.000386410140064876 0.00841320259504888 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 34/980 349/18639 0.0974212034383954 1.85289164376352 0.000410899970365499 0.00874760381355885 GO:0051117 ATPase binding 13/980 84/18639 0.154761904761905 2.94347667638484 0.000420923676688295 0.00876619309276928 GO:0003925 G protein activity 10/980 54/18639 0.185185185185185 3.52210884353741 0.000446430865153097 0.00909959082588653 GO:0003725 double-stranded RNA binding 12/980 75/18639 0.16 3.04310204081633 0.000508649104762886 0.0101517883825593 GO:0019763 immunoglobulin receptor activity 5/980 14/18639 0.357142857142857 6.79263848396501 0.000534485132595103 0.0104497297352267 GO:0060590 ATPase regulator activity 9/980 49/18639 0.183673469387755 3.49335693461058 0.000908838605726685 0.0174133476857233 GO:0061791 GTPase motor activity 8/980 40/18639 0.2 3.80387755102041 0.000970706943521769 0.0178834086902664 GO:1990606 membrane scission GTPase motor activity 8/980 40/18639 0.2 3.80387755102041 0.000970706943521769 0.0178834086902664 GO:0042287 MHC protein binding 8/980 41/18639 0.195121951219512 3.71110004977601 0.00115124911691298 0.0204259630380946 GO:0019208 phosphatase regulator activity 15/980 117/18639 0.128205128205128 2.4383830455259 0.00121180940591395 0.0204259630380946 GO:0005131 growth hormone receptor binding 4/980 10/18639 0.4 7.60775510204082 0.00123563400072512 0.0204259630380946 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/980 10/18639 0.4 7.60775510204082 0.00123563400072512 0.0204259630380946 GO:0032395 MHC class II receptor activity 4/980 10/18639 0.4 7.60775510204082 0.00123563400072512 0.0204259630380946 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/980 24/18639 0.25 4.75484693877551 0.00123664494385124 0.0204259630380946 GO:0140311 protein sequestering activity 7/980 33/18639 0.212121212121212 4.03441558441558 0.00139468563208232 0.0223712209191697 GO:0008429 phosphatidylethanolamine binding 5/980 17/18639 0.294117647058824 5.59393757503001 0.00144782431835963 0.0223712209191697 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/980 17/18639 0.294117647058824 5.59393757503001 0.00144782431835963 0.0223712209191697 GO:0045236 CXCR chemokine receptor binding 5/980 17/18639 0.294117647058824 5.59393757503001 0.00144782431835963 0.0223712209191697 GO:0140296 general transcription initiation factor binding 9/980 53/18639 0.169811320754717 3.22970735463997 0.00162473466115915 0.0247062826252455 GO:0051082 unfolded protein binding 15/980 121/18639 0.12396694214876 2.35777534154158 0.00170612073970586 0.0255384948224722 GO:0030246 carbohydrate binding 27/980 280/18639 0.0964285714285714 1.83401239067055 0.00179404809719035 0.0262490395882377 GO:0051087 protein-folding chaperone binding 16/980 134/18639 0.119402985074627 2.27097167225099 0.00180838894866773 0.0262490395882377 GO:0140031 phosphorylation-dependent protein binding 4/980 11/18639 0.363636363636364 6.91614100185529 0.00186124261449449 0.0266129914132198 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/980 45/18639 0.177777777777778 3.38122448979592 0.00215726152599196 0.030392007969122 GO:0043021 ribonucleoprotein complex binding 19/980 177/18639 0.107344632768362 2.0416291940505 0.00249925074407993 0.0346997422149068 GO:0097677 STAT family protein binding 4/980 12/18639 0.333333333333333 6.33979591836735 0.00267638430813328 0.0366282309598812 GO:1990841 promoter-specific chromatin binding 10/980 68/18639 0.147058823529412 2.79696878751501 0.00279468377167743 0.0377085500460138 GO:0046625 sphingolipid binding 6/980 28/18639 0.214285714285714 4.07558309037901 0.0028922384269323 0.0384828390694604 GO:0016505 peptidase activator activity involved in apoptotic process 5/980 20/18639 0.25 4.75484693877551 0.00318091194293829 0.0417440224840395 GO:0043560 insulin receptor substrate binding 4/980 13/18639 0.307692307692308 5.85211930926217 0.00370629186414826 0.0479814541331626 GO:0019903 protein phosphatase binding 16/980 144/18639 0.111111111111111 2.11326530612245 0.00376078879199282 0.0480378088363883 GO:0001098 basal transcription machinery binding 9/980 60/18639 0.15 2.85290816326531 0.0039063581817971 0.0486011836124886 GO:0001099 basal RNA polymerase II transcription machinery binding 9/980 60/18639 0.15 2.85290816326531 0.0039063581817971 0.0486011836124886 GO:0019888 protein phosphatase regulator activity 13/980 107/18639 0.121495327102804 2.31076673660118 0.00402035158524129 0.0493781643418097 GO:0048020 CCR chemokine receptor binding 8/980 50/18639 0.16 3.04310204081633 0.00426421750758121 0.0517103844590228 GO:0003823 antigen binding 18/980 174/18639 0.103448275862069 1.96752287121745 0.00473969681330769 0.0567578693393596 GO:0030544 Hsp70 protein binding 8/980 51/18639 0.156862745098039 2.98343337334934 0.00482962914355317 0.0571207990064683 GO:0140517 protein-RNA adaptor activity 5/980 22/18639 0.227272727272727 4.32258812615955 0.00495139585502275 0.0578467954769731 GO:0048029 monosaccharide binding 10/980 74/18639 0.135135135135135 2.57018753447325 0.00520580371399152 0.0600862645542636 GO:0042056 chemoattractant activity 7/980 42/18639 0.166666666666667 3.16989795918367 0.00584264743060546 0.0666340028395242 GO:0031386 protein tag activity 4/980 15/18639 0.266666666666667 5.07183673469388 0.00650513592457436 0.0716312668476119 GO:0050700 CARD domain binding 4/980 15/18639 0.266666666666667 5.07183673469388 0.00650513592457436 0.0716312668476119 GO:0141047 molecular tag activity 4/980 15/18639 0.266666666666667 5.07183673469388 0.00650513592457436 0.0716312668476119 GO:0019843 rRNA binding 9/980 65/18639 0.138461538461538 2.63345368916797 0.0066919691479334 0.0728512095877295 GO:0035035 histone acetyltransferase binding 5/980 24/18639 0.208333333333333 3.96237244897959 0.00732586801264974 0.0779797950679827 GO:0048027 mRNA 5'-UTR binding 5/980 24/18639 0.208333333333333 3.96237244897959 0.00732586801264974 0.0779797950679827 GO:0051427 hormone receptor binding 6/980 34/18639 0.176470588235294 3.35636254501801 0.0078985154401443 0.0831514043039367 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/980 16/18639 0.25 4.75484693877551 0.00831755416844113 0.0866110531887674 GO:0140223 general transcription initiation factor activity 9/980 68/18639 0.132352941176471 2.51727190876351 0.00897463938486922 0.0917683288568192 GO:0048306 calcium-dependent protein binding 10/980 80/18639 0.125 2.37742346938776 0.00900440805066911 0.0917683288568192 GO:0061631 ubiquitin conjugating enzyme activity 6/980 35/18639 0.171428571428571 3.26046647230321 0.00911820389800221 0.0919498877293275 GO:0051219 phosphoprotein binding 11/980 93/18639 0.118279569892473 2.24960500329164 0.00950309452137536 0.0948329640778916 GO:0001618 virus receptor activity 10/980 81/18639 0.123456790123457 2.34807256235828 0.00980299717406832 0.0968172298222418 GO:0008157 protein phosphatase 1 binding 5/980 26/18639 0.192307692307692 3.65757456828885 0.0103958326225777 0.101283583562463 GO:0005484 SNAP receptor activity 6/980 36/18639 0.166666666666667 3.16989795918367 0.0104666751280624 0.101283583562463 GO:0140272 exogenous protein binding 10/980 82/18639 0.121951219512195 2.31943753111001 0.0106544511933667 0.102004195083096 GO:0004866 endopeptidase inhibitor activity 16/980 161/18639 0.0993788819875776 1.89012549119026 0.0108168079941383 0.102004195083096 GO:0001784 phosphotyrosine residue binding 7/980 47/18639 0.148936170212766 2.83267477203647 0.0108605719190771 0.102004195083096 GO:0070063 RNA polymerase binding 8/980 59/18639 0.135593220338983 2.57890003459011 0.011646526756564 0.108324006143576 GO:0070513 death domain binding 3/980 10/18639 0.3 5.70581632653061 0.013164459861431 0.121264928338951 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/980 39/18639 0.153846153846154 2.92605965463108 0.0153509876688516 0.14005948749295 GO:0097001 ceramide binding 4/980 19/18639 0.210526315789474 4.00408163265306 0.0156291540662072 0.141252165994589 GO:0003785 actin monomer binding 5/980 29/18639 0.172413793103448 3.27920478536242 0.0164871951398376 0.145833866289484 GO:0044183 protein folding chaperone 9/980 75/18639 0.12 2.28232653061224 0.0165454401493009 0.145833866289484 GO:0030414 peptidase inhibitor activity 16/980 169/18639 0.0946745562130177 1.80065209515759 0.0165927885444194 0.145833866289484 GO:0019207 kinase regulator activity 24/980 287/18639 0.0836236933797909 1.590471449904 0.0170613165091168 0.147541887993034 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/980 11/18639 0.272727272727273 5.18710575139147 0.0174031663290322 0.147541887993034 GO:0042608 T cell receptor binding 3/980 11/18639 0.272727272727273 5.18710575139147 0.0174031663290322 0.147541887993034 GO:0050786 RAGE receptor binding 3/980 11/18639 0.272727272727273 5.18710575139147 0.0174031663290322 0.147541887993034 GO:0101005 deubiquitinase activity 12/980 115/18639 0.104347826086957 1.98463176574978 0.0178136590871305 0.149299216135963 GO:0017022 myosin binding 9/980 76/18639 0.118421052631579 2.25229591836735 0.0179221397240457 0.149299216135963 GO:0003727 single-stranded RNA binding 10/980 89/18639 0.112359550561798 2.13700986012382 0.0182720766333697 0.149729237257139 GO:0035591 signaling adaptor activity 13/980 129/18639 0.10077519379845 1.91668248694827 0.0182863473476882 0.149729237257139 GO:0019210 kinase inhibitor activity 10/980 90/18639 0.111111111111111 2.11326530612245 0.0196221137599879 0.159304957475156 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/980 53/18639 0.132075471698113 2.51199460916442 0.020317691612099 0.163565954322612 GO:0016859 cis-trans isomerase activity 6/980 42/18639 0.142857142857143 2.71705539358601 0.0216227465311366 0.171060510567727 GO:0051879 Hsp90 protein binding 6/980 42/18639 0.142857142857143 2.71705539358601 0.0216227465311366 0.171060510567727 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/980 21/18639 0.19047619047619 3.62274052478134 0.0222105412459699 0.171060510567727 GO:0004859 phospholipase inhibitor activity 3/980 12/18639 0.25 4.75484693877551 0.0223120936693318 0.171060510567727 GO:0035259 nuclear glucocorticoid receptor binding 3/980 12/18639 0.25 4.75484693877551 0.0223120936693318 0.171060510567727 GO:0017069 snRNA binding 7/980 54/18639 0.12962962962963 2.46547619047619 0.0223200039884821 0.171060510567727 GO:0046332 SMAD binding 9/980 79/18639 0.113924050632911 2.16676569361922 0.0225509078372653 0.171458489746827 GO:0001046 core promoter sequence-specific DNA binding 6/980 44/18639 0.136363636363636 2.59355287569573 0.0266479194358583 0.200022011540224 GO:0019212 phosphatase inhibitor activity 7/980 56/18639 0.125 2.37742346938776 0.0267252792037042 0.200022011540224 GO:0051015 actin filament binding 18/980 209/18639 0.0861244019138756 1.63803339517625 0.0274588443205362 0.203919169450183 GO:0005035 death receptor activity 3/980 13/18639 0.230769230769231 4.38908948194663 0.0278938342108869 0.203986970794119 GO:0035325 Toll-like receptor binding 3/980 13/18639 0.230769230769231 4.38908948194663 0.0278938342108869 0.203986970794119 GO:0003713 transcription coactivator activity 21/980 256/18639 0.08203125 1.56018415178571 0.029405047445751 0.213409359492647 GO:0003712 transcription coregulator activity 36/980 495/18639 0.0727272727272727 1.38322820037106 0.0309484291013481 0.222921767511966 GO:0061980 regulatory RNA binding 7/980 58/18639 0.120689655172414 2.2954433497537 0.0316876133305592 0.226542787840864 GO:0004860 protein kinase inhibitor activity 9/980 84/18639 0.107142857142857 2.0377915451895 0.0320680992083893 0.227564733641755 GO:0016530 metallochaperone activity 3/980 14/18639 0.214285714285714 4.07558309037901 0.0341444213892825 0.236712104954149 GO:0032036 myosin heavy chain binding 3/980 14/18639 0.214285714285714 4.07558309037901 0.0341444213892825 0.236712104954149 GO:0044548 S100 protein binding 3/980 14/18639 0.214285714285714 4.07558309037901 0.0341444213892825 0.236712104954149 GO:0045309 protein phosphorylated amino acid binding 7/980 59/18639 0.11864406779661 2.25653753026634 0.0343854519078278 0.236712104954149 GO:0015149 hexose transmembrane transporter activity 4/980 24/18639 0.166666666666667 3.16989795918367 0.0348396730673643 0.236712104954149 GO:0055056 D-glucose transmembrane transporter activity 4/980 24/18639 0.166666666666667 3.16989795918367 0.0348396730673643 0.236712104954149 GO:0019783 ubiquitin-like protein peptidase activity 12/980 127/18639 0.094488188976378 1.79710750441909 0.0353238818165906 0.238311822396435 GO:0001221 transcription coregulator binding 11/980 115/18639 0.0956521739130435 1.81924578527063 0.0395985844957036 0.262991628462369 GO:0140104 molecular carrier activity 20/980 249/18639 0.0803212851405622 1.52766166707647 0.0397206966580776 0.262991628462369 GO:0019211 phosphatase activator activity 4/980 25/18639 0.16 3.04310204081633 0.0398056222620496 0.262991628462369 GO:0005523 tropomyosin binding 3/980 15/18639 0.2 3.80387755102041 0.0410542427554595 0.269383318902262 GO:0009055 electron transfer activity 11/980 116/18639 0.0948275862068965 1.80356263194933 0.0417614301327781 0.272159524266676 GO:0016763 pentosyltransferase activity 6/980 49/18639 0.122448979591837 2.32890462307372 0.0424180099914847 0.274570632242178 GO:0019902 phosphatase binding 16/980 190/18639 0.0842105263157895 1.60163265306122 0.0429463687773403 0.276124975091892 GO:0008198 ferrous iron binding 4/980 26/18639 0.153846153846154 2.92605965463108 0.0451528567419536 0.284581820781523 GO:0015145 monosaccharide transmembrane transporter activity 4/980 26/18639 0.153846153846154 2.92605965463108 0.0451528567419536 0.284581820781523 GO:0070412 R-SMAD binding 4/980 26/18639 0.153846153846154 2.92605965463108 0.0451528567419536 0.284581820781523 GO:0030275 LRR domain binding 3/980 16/18639 0.1875 3.56613520408163 0.0486088631986177 0.30144589778189 GO:0055102 lipase inhibitor activity 3/980 16/18639 0.1875 3.56613520408163 0.0486088631986177 0.30144589778189 GO:0019887 protein kinase regulator activity 20/980 255/18639 0.0784313725490196 1.49171668667467 0.0487725617496796 0.30144589778189 GO:0000149 SNARE binding 10/980 106/18639 0.0943396226415094 1.79428186368887 0.0521724872016296 0.32039258166129 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/980 17/18639 0.176470588235294 3.35636254501801 0.056789765912771 0.337813074054734 GO:0038191 neuropilin binding 3/980 17/18639 0.176470588235294 3.35636254501801 0.056789765912771 0.337813074054734 GO:0048038 quinone binding 3/980 17/18639 0.176470588235294 3.35636254501801 0.056789765912771 0.337813074054734 GO:0051019 mitogen-activated protein kinase binding 4/980 28/18639 0.142857142857143 2.71705539358601 0.056986394888716 0.337813074054734 GO:0051119 sugar transmembrane transporter activity 4/980 28/18639 0.142857142857143 2.71705539358601 0.056986394888716 0.337813074054734 GO:0015036 disulfide oxidoreductase activity 5/980 40/18639 0.125 2.37742346938776 0.0571249665938068 0.337813074054734 GO:0004843 cysteine-type deubiquitinase activity 10/980 108/18639 0.0925925925925926 1.76105442176871 0.0578649866880991 0.340089921761957 GO:0004864 protein phosphatase inhibitor activity 6/980 53/18639 0.113207547169811 2.15313823642665 0.0585260877388515 0.341878000328169 GO:0001530 lipopolysaccharide binding 5/980 41/18639 0.121951219512195 2.31943753111001 0.0623689276957755 0.355559553455543 GO:0017080 sodium channel regulator activity 5/980 41/18639 0.121951219512195 2.31943753111001 0.0623689276957755 0.355559553455543 GO:0042169 SH2 domain binding 5/980 41/18639 0.121951219512195 2.31943753111001 0.0623689276957755 0.355559553455543 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/980 54/18639 0.111111111111111 2.11326530612245 0.0630518482076477 0.355559553455543 GO:0140463 chromatin-protein adaptor activity 6/980 54/18639 0.111111111111111 2.11326530612245 0.0630518482076477 0.355559553455543 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/980 29/18639 0.137931034482759 2.62336382828994 0.0634662668485365 0.355559553455543 GO:0051861 glycolipid binding 4/980 29/18639 0.137931034482759 2.62336382828994 0.0634662668485365 0.355559553455543 GO:0003746 translation elongation factor activity 3/980 18/18639 0.166666666666667 3.16989795918367 0.0655750180613085 0.358976384587049 GO:0030228 lipoprotein particle receptor activity 3/980 18/18639 0.166666666666667 3.16989795918367 0.0655750180613085 0.358976384587049 GO:0050811 GABA receptor binding 3/980 18/18639 0.166666666666667 3.16989795918367 0.0655750180613085 0.358976384587049 GO:0098641 cadherin binding involved in cell-cell adhesion 3/980 18/18639 0.166666666666667 3.16989795918367 0.0655750180613085 0.358976384587049 GO:0043175 RNA polymerase core enzyme binding 5/980 42/18639 0.119047619047619 2.26421282798834 0.0678751683936996 0.367369555486804 GO:0048487 beta-tubulin binding 5/980 42/18639 0.119047619047619 2.26421282798834 0.0678751683936996 0.367369555486804 GO:0008234 cysteine-type peptidase activity 15/980 187/18639 0.0802139037433155 1.52561933864455 0.0685708146496304 0.36820320711271 GO:0019787 ubiquitin-like protein transferase activity 33/980 479/18639 0.0688935281837161 1.31031272634315 0.0687978852538362 0.36820320711271 GO:0016755 aminoacyltransferase activity 34/980 496/18639 0.0685483870967742 1.30374835418038 0.0692056366981502 0.368327777537933 GO:0001968 fibronectin binding 4/980 30/18639 0.133333333333333 2.53591836734694 0.0703147680721234 0.370118394577441 GO:0051721 protein phosphatase 2A binding 4/980 30/18639 0.133333333333333 2.53591836734694 0.0703147680721234 0.370118394577441 GO:0031490 chromatin DNA binding 11/980 128/18639 0.0859375 1.63447863520408 0.0742407421349231 0.385980608187386 GO:0034987 immunoglobulin receptor binding 3/980 19/18639 0.157894736842105 3.0030612244898 0.0749398675603901 0.385980608187386 GO:0050145 nucleoside monophosphate kinase activity 3/980 19/18639 0.157894736842105 3.0030612244898 0.0749398675603901 0.385980608187386 GO:0070003 threonine-type peptidase activity 3/980 19/18639 0.157894736842105 3.0030612244898 0.0749398675603901 0.385980608187386 GO:0019955 cytokine binding 12/980 144/18639 0.0833333333333333 1.58494897959184 0.0770989359066953 0.394977436356225 GO:0000339 RNA cap binding 3/980 20/18639 0.15 2.85290816326531 0.0848572769068663 0.424560121562559 GO:0016004 phospholipase activator activity 3/980 20/18639 0.15 2.85290816326531 0.0848572769068663 0.424560121562559 GO:0030742 GTP-dependent protein binding 3/980 20/18639 0.15 2.85290816326531 0.0848572769068663 0.424560121562559 GO:0043024 ribosomal small subunit binding 3/980 20/18639 0.15 2.85290816326531 0.0848572769068663 0.424560121562559 GO:0043425 bHLH transcription factor binding 4/980 32/18639 0.125 2.37742346938776 0.0850892936743334 0.424560121562559 GO:0001786 phosphatidylserine binding 6/980 59/18639 0.101694915254237 1.93417502594258 0.0886752854278022 0.432681832878204 GO:0019956 chemokine binding 4/980 33/18639 0.121212121212121 2.30538033395176 0.0929981613685902 0.432681832878204 GO:0071889 14-3-3 protein binding 4/980 33/18639 0.121212121212121 2.30538033395176 0.0929981613685902 0.432681832878204 GO:0003684 damaged DNA binding 7/980 74/18639 0.0945945945945946 1.79913127413127 0.0935465962766574 0.432681832878204 GO:0001094 TFIID-class transcription factor complex binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0004090 carbonyl reductase (NADPH) activity 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0005031 tumor necrosis factor receptor activity 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0005522 profilin binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0030957 Tat protein binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0031720 haptoglobin binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0031996 thioesterase binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0043208 glycosphingolipid binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0050308 sugar-phosphatase activity 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0071723 lipopeptide binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0098505 G-rich strand telomeric DNA binding 2/980 10/18639 0.2 3.80387755102041 0.093903583363417 0.432681832878204 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/980 21/18639 0.142857142857143 2.71705539358601 0.0952983995170158 0.432681832878204 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/980 21/18639 0.142857142857143 2.71705539358601 0.0952983995170158 0.432681832878204 GO:0051428 peptide hormone receptor binding 3/980 21/18639 0.142857142857143 2.71705539358601 0.0952983995170158 0.432681832878204 GO:0072542 protein phosphatase activator activity 3/980 21/18639 0.142857142857143 2.71705539358601 0.0952983995170158 0.432681832878204 GO:0001217 DNA-binding transcription repressor activity 20/980 278/18639 0.0719424460431655 1.36830127734547 0.0969561196991667 0.438131899395291 GO:0000287 magnesium ion binding 17/980 230/18639 0.0739130434782609 1.40578083407276 0.0991528531914403 0.445955086184975 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/980 34/18639 0.117647058823529 2.237575030012 0.10124155979892 0.453221562090494 GO:0016922 nuclear receptor binding 11/980 137/18639 0.0802919708029197 1.52710412632206 0.10691636495514 0.472203207307291 GO:0051020 GTPase binding 22/980 315/18639 0.0698412698412698 1.32833819241983 0.107381057460904 0.472203207307291 GO:0043015 gamma-tubulin binding 4/980 35/18639 0.114285714285714 2.1736443148688 0.109808416803301 0.472203207307291 GO:0140566 histone reader activity 4/980 35/18639 0.114285714285714 2.1736443148688 0.109808416803301 0.472203207307291 GO:0031267 small GTPase binding 20/980 283/18639 0.0706713780918728 1.34412634311675 0.110459668789538 0.472203207307291 GO:0005536 D-glucose binding 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0010854 adenylate cyclase regulator activity 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0019203 carbohydrate phosphatase activity 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0043522 leucine zipper domain binding 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0070990 snRNP binding 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/980 11/18639 0.181818181818182 3.45807050092764 0.110903676037725 0.472203207307291 GO:0001222 transcription corepressor binding 5/980 49/18639 0.102040816326531 1.94075385256143 0.113532427548488 0.481256927395804 GO:0042171 lysophosphatidic acid acyltransferase activity 3/980 23/18639 0.130434782608696 2.48078970718722 0.117629848324974 0.485789931103877 GO:0043274 phospholipase binding 3/980 23/18639 0.130434782608696 2.48078970718722 0.117629848324974 0.485789931103877 GO:0071617 lysophospholipid acyltransferase activity 3/980 23/18639 0.130434782608696 2.48078970718722 0.117629848324974 0.485789931103877 GO:0000993 RNA polymerase II complex binding 4/980 36/18639 0.111111111111111 2.11326530612245 0.11868684925493 0.485789931103877 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/980 36/18639 0.111111111111111 2.11326530612245 0.11868684925493 0.485789931103877 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/980 36/18639 0.111111111111111 2.11326530612245 0.11868684925493 0.485789931103877 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/980 36/18639 0.111111111111111 2.11326530612245 0.11868684925493 0.485789931103877 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/980 36/18639 0.111111111111111 2.11326530612245 0.11868684925493 0.485789931103877 GO:0030695 GTPase regulator activity 32/980 489/18639 0.065439672801636 1.24462251158132 0.119165588527569 0.485789931103877 GO:0060589 nucleoside-triphosphatase regulator activity 32/980 490/18639 0.0653061224489796 1.24208246563932 0.121415207744719 0.492863428048476 GO:0042805 actinin binding 4/980 37/18639 0.108108108108108 2.0561500275786 0.127864262213242 0.5062033532152 GO:0004126 cytidine deaminase activity 2/980 12/18639 0.166666666666667 3.16989795918367 0.128621992511403 0.5062033532152 GO:0035197 siRNA binding 2/980 12/18639 0.166666666666667 3.16989795918367 0.128621992511403 0.5062033532152 GO:0035497 cAMP response element binding 2/980 12/18639 0.166666666666667 3.16989795918367 0.128621992511403 0.5062033532152 GO:0043047 single-stranded telomeric DNA binding 2/980 12/18639 0.166666666666667 3.16989795918367 0.128621992511403 0.5062033532152 GO:0005540 hyaluronic acid binding 3/980 24/18639 0.125 2.37742346938776 0.129457016218919 0.5062033532152 GO:0019957 C-C chemokine binding 3/980 24/18639 0.125 2.37742346938776 0.129457016218919 0.5062033532152 GO:0030215 semaphorin receptor binding 3/980 24/18639 0.125 2.37742346938776 0.129457016218919 0.5062033532152 GO:0060229 lipase activator activity 3/980 24/18639 0.125 2.37742346938776 0.129457016218919 0.5062033532152 GO:0042826 histone deacetylase binding 10/980 127/18639 0.078740157480315 1.49758958701591 0.131816070121651 0.512568772211761 GO:0016407 acetyltransferase activity 8/980 96/18639 0.0833333333333333 1.58494897959184 0.13215499659322 0.512568772211761 GO:0043022 ribosome binding 9/980 112/18639 0.0803571428571429 1.52834365889213 0.13511826759294 0.521948791750148 GO:0042162 telomeric DNA binding 4/980 38/18639 0.105263157894737 2.00204081632653 0.137327444523997 0.526238767415956 GO:0043531 ADP binding 4/980 38/18639 0.105263157894737 2.00204081632653 0.137327444523997 0.526238767415956 GO:0005543 phospholipid binding 32/980 497/18639 0.0643863179074447 1.22458834640496 0.137903207862615 0.526339733595161 GO:0005537 D-mannose binding 3/980 25/18639 0.12 2.28232653061224 0.141682206303946 0.536488354305061 GO:0017056 structural constituent of nuclear pore 3/980 25/18639 0.12 2.28232653061224 0.141682206303946 0.536488354305061 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0030955 potassium ion binding 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0089720 caspase binding 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0140852 histone ubiquitin ligase activity 2/980 13/18639 0.153846153846154 2.92605965463108 0.146936203111497 0.54349375513828 GO:0004842 ubiquitin-protein transferase activity 29/980 449/18639 0.0645879732739421 1.22842370801327 0.147803970475145 0.544600783519957 GO:0035401 histone H3Y41 kinase activity 9/980 115/18639 0.0782608695652174 1.48847382431233 0.151345525687836 0.553393181713537 GO:0140801 histone H2AXY142 kinase activity 9/980 115/18639 0.0782608695652174 1.48847382431233 0.151345525687836 0.553393181713537 GO:0051287 NAD binding 5/980 54/18639 0.0925925925925926 1.76105442176871 0.153140200928995 0.55520072565924 GO:0043548 phosphatidylinositol 3-kinase binding 3/980 26/18639 0.115384615384615 2.19454474097331 0.154272991029423 0.55520072565924 GO:0005085 guanyl-nucleotide exchange factor activity 16/980 230/18639 0.0695652173913043 1.32308784383319 0.155159392755458 0.55520072565924 GO:0140713 histone chaperone activity 12/980 164/18639 0.0731707317073171 1.391662518666 0.15531679740469 0.55520072565924 GO:0043130 ubiquitin binding 8/980 100/18639 0.08 1.52155102040816 0.155616441017959 0.55520072565924 GO:0042393 histone binding 17/980 247/18639 0.0688259109311741 1.30902668759812 0.156204108039835 0.55520072565924 GO:0015144 carbohydrate transmembrane transporter activity 4/980 40/18639 0.1 1.9019387755102 0.157055737634294 0.55520072565924 GO:0050997 quaternary ammonium group binding 4/980 40/18639 0.1 1.9019387755102 0.157055737634294 0.55520072565924 GO:0140662 ATP-dependent protein folding chaperone 4/980 40/18639 0.1 1.9019387755102 0.157055737634294 0.55520072565924 GO:0005161 platelet-derived growth factor receptor binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0005344 oxygen carrier activity 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0005545 1-phosphatidylinositol binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0008191 metalloendopeptidase inhibitor activity 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0031404 chloride ion binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0070742 C2H2 zinc finger domain binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0098847 sequence-specific single stranded DNA binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:1990825 sequence-specific mRNA binding 2/980 14/18639 0.142857142857143 2.71705539358601 0.165734833398533 0.568108345579307 GO:0016209 antioxidant activity 7/980 86/18639 0.0813953488372093 1.54808970099668 0.166044192862428 0.568108345579307 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 18/980 268/18639 0.0671641791044776 1.27742156564118 0.172006899674892 0.586414981809774 GO:0061659 ubiquitin-like protein ligase activity 24/980 372/18639 0.0645161290322581 1.22705727452271 0.175972315310354 0.596464549810273 GO:0035198 miRNA binding 4/980 42/18639 0.0952380952380952 1.81137026239067 0.177757094901207 0.596464549810273 GO:0004601 peroxidase activity 5/980 57/18639 0.087719298245614 1.66836734693878 0.179300035571365 0.596464549810273 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/980 88/18639 0.0795454545454545 1.51290584415584 0.180051465256913 0.596464549810273 GO:0019789 SUMO transferase activity 3/980 28/18639 0.107142857142857 2.0377915451895 0.180422318168368 0.596464549810273 GO:0046875 ephrin receptor binding 3/980 28/18639 0.107142857142857 2.0377915451895 0.180422318168368 0.596464549810273 GO:0046966 nuclear thyroid hormone receptor binding 3/980 28/18639 0.107142857142857 2.0377915451895 0.180422318168368 0.596464549810273 GO:0097718 disordered domain specific binding 3/980 28/18639 0.107142857142857 2.0377915451895 0.180422318168368 0.596464549810273 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0004953 icosanoid receptor activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0005041 low-density lipoprotein particle receptor activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0033130 acetylcholine receptor binding 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0120283 protein serine/threonine kinase binding 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0140776 protein-containing complex destabilizing activity 2/980 15/18639 0.133333333333333 2.53591836734694 0.184916462728237 0.596464549810273 GO:0140597 protein carrier chaperone 13/980 188/18639 0.0691489361702128 1.31517042987408 0.191253120555192 0.614833857355282 GO:0106222 lncRNA binding 3/980 29/18639 0.103448275862069 1.96752287121745 0.19391724716681 0.621313454133123 GO:0070851 growth factor receptor binding 10/980 139/18639 0.0719424460431655 1.36830127734547 0.19627329457712 0.62676605401627 GO:0004879 nuclear receptor activity 5/980 59/18639 0.0847457627118644 1.61181252161882 0.197601417502181 0.626828337639368 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/980 59/18639 0.0847457627118644 1.61181252161882 0.197601417502181 0.626828337639368 GO:0030547 signaling receptor inhibitor activity 4/980 44/18639 0.0909090909090909 1.72903525046382 0.199312446797552 0.627537917996827 GO:0072341 modified amino acid binding 7/980 91/18639 0.0769230769230769 1.46302982731554 0.201946657731285 0.627537917996827 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0005149 interleukin-1 receptor binding 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0005521 lamin binding 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0008142 oxysterol binding 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0017070 U6 snRNA binding 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0034450 ubiquitin-ubiquitin ligase activity 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0043023 ribosomal large subunit binding 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/980 16/18639 0.125 2.37742346938776 0.204388976946754 0.627537917996827 GO:0098531 ligand-modulated transcription factor activity 5/980 60/18639 0.0833333333333333 1.58494897959184 0.206984158255529 0.627537917996827 GO:0001965 G-protein alpha-subunit binding 3/980 30/18639 0.1 1.9019387755102 0.207650855955109 0.627537917996827 GO:0008187 poly-pyrimidine tract binding 3/980 30/18639 0.1 1.9019387755102 0.207650855955109 0.627537917996827 GO:0031210 phosphatidylcholine binding 3/980 30/18639 0.1 1.9019387755102 0.207650855955109 0.627537917996827 GO:0070566 adenylyltransferase activity 3/980 30/18639 0.1 1.9019387755102 0.207650855955109 0.627537917996827 GO:0051539 4 iron, 4 sulfur cluster binding 4/980 45/18639 0.0888888888888889 1.69061224489796 0.210372520803624 0.633763757641106 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/980 61/18639 0.0819672131147541 1.55896620943459 0.216509530693417 0.648175407513418 GO:0019905 syntaxin binding 5/980 61/18639 0.0819672131147541 1.55896620943459 0.216509530693417 0.648175407513418 GO:0008327 methyl-CpG binding 3/980 31/18639 0.0967741935483871 1.84058591178407 0.221592899560465 0.650478724659791 GO:0016411 acylglycerol O-acyltransferase activity 3/980 31/18639 0.0967741935483871 1.84058591178407 0.221592899560465 0.650478724659791 GO:0005092 GDP-dissociation inhibitor activity 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0008484 sulfuric ester hydrolase activity 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0017110 nucleoside diphosphate phosphatase activity 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0031489 myosin V binding 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0045125 bioactive lipid receptor activity 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0046965 nuclear retinoid X receptor binding 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0051787 misfolded protein binding 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0070492 oligosaccharide binding 2/980 17/18639 0.117647058823529 2.237575030012 0.224068871751285 0.650478724659791 GO:0046982 protein heterodimerization activity 23/980 369/18639 0.0623306233062331 1.18549029367845 0.227799031298921 0.659309583034341 GO:0033218 amide binding 16/980 247/18639 0.0647773279352227 1.2320251177394 0.229110719239845 0.661108641661963 GO:0061630 ubiquitin protein ligase activity 22/980 353/18639 0.0623229461756374 1.1853442793548 0.234117815919588 0.669231951767952 GO:0030515 snoRNA binding 3/980 32/18639 0.09375 1.78306760204082 0.235713962238341 0.669231951767952 GO:0051059 NF-kappaB binding 3/980 32/18639 0.09375 1.78306760204082 0.235713962238341 0.669231951767952 GO:0005507 copper ion binding 5/980 63/18639 0.0793650793650794 1.50947521865889 0.235951426110335 0.669231951767952 GO:0005200 structural constituent of cytoskeleton 8/980 112/18639 0.0714285714285714 1.358527696793 0.236229146487026 0.669231951767952 GO:0016853 isomerase activity 12/980 180/18639 0.0666666666666667 1.26795918367347 0.238875152923582 0.669231951767952 GO:0004896 cytokine receptor activity 7/980 96/18639 0.0729166666666667 1.38683035714286 0.240517211584069 0.669231951767952 GO:0000400 four-way junction DNA binding 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0000900 mRNA regulatory element binding translation repressor activity 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0004706 JUN kinase kinase kinase activity 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0016854 racemase and epimerase activity 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0017075 syntaxin-1 binding 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0017128 phospholipid scramblase activity 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0070628 proteasome binding 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:1901611 phosphatidylglycerol binding 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:1990381 ubiquitin-specific protease binding 2/980 18/18639 0.111111111111111 2.11326530612245 0.243880603462532 0.669231951767952 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/980 48/18639 0.0833333333333333 1.58494897959184 0.244500191146955 0.669231951767952 GO:0140693 molecular condensate scaffold activity 4/980 48/18639 0.0833333333333333 1.58494897959184 0.244500191146955 0.669231951767952 GO:0019239 deaminase activity 3/980 33/18639 0.0909090909090909 1.72903525046382 0.249985542325316 0.680358379396741 GO:0140416 transcription regulator inhibitor activity 3/980 33/18639 0.0909090909090909 1.72903525046382 0.249985542325316 0.680358379396741 GO:0019209 kinase activator activity 10/980 148/18639 0.0675675675675676 1.28509376723662 0.25200467953601 0.683910716701126 GO:0038024 cargo receptor activity 5/980 65/18639 0.0769230769230769 1.46302982731554 0.255853158804578 0.691222016303886 GO:0035254 glutamate receptor binding 4/980 49/18639 0.0816326530612245 1.55260308204915 0.256141770133486 0.691222016303886 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/980 19/18639 0.105263157894737 2.00204081632653 0.263755984156902 0.701596000514529 GO:0031420 alkali metal ion binding 2/980 19/18639 0.105263157894737 2.00204081632653 0.263755984156902 0.701596000514529 GO:0042834 peptidoglycan binding 2/980 19/18639 0.105263157894737 2.00204081632653 0.263755984156902 0.701596000514529 GO:0015035 protein-disulfide reductase activity 3/980 34/18639 0.0882352941176471 1.678181272509 0.264380121279483 0.701596000514529 GO:0019825 oxygen binding 3/980 34/18639 0.0882352941176471 1.678181272509 0.264380121279483 0.701596000514529 GO:0090482 vitamin transmembrane transporter activity 3/980 34/18639 0.0882352941176471 1.678181272509 0.264380121279483 0.701596000514529 GO:1901981 phosphatidylinositol phosphate binding 12/980 185/18639 0.0648648648648649 1.23369001654716 0.26801731342851 0.709283387471029 GO:0001540 amyloid-beta binding 6/980 83/18639 0.072289156626506 1.37489550036882 0.270792545903035 0.714653605992031 GO:0016887 ATP hydrolysis activity 25/980 417/18639 0.0599520383693046 1.14025106445456 0.27670537494974 0.727952663198943 GO:0140674 ATP-dependent histone chaperone activity 10/980 152/18639 0.0657894736842105 1.25127551020408 0.278363059919354 0.727952663198943 GO:0005154 epidermal growth factor receptor binding 3/980 35/18639 0.0857142857142857 1.6302332361516 0.278871218574126 0.727952663198943 GO:0034061 DNA polymerase activity 3/980 35/18639 0.0857142857142857 1.6302332361516 0.278871218574126 0.727952663198943 GO:0010851 cyclase regulator activity 2/980 20/18639 0.1 1.9019387755102 0.283633618295795 0.734074047699359 GO:0016408 C-acyltransferase activity 2/980 20/18639 0.1 1.9019387755102 0.283633618295795 0.734074047699359 GO:0031418 L-ascorbic acid binding 2/980 20/18639 0.1 1.9019387755102 0.283633618295795 0.734074047699359 GO:0001216 DNA-binding transcription activator activity 29/980 491/18639 0.0590631364562118 1.1233446942932 0.284281285695681 0.734074047699359 GO:0003774 cytoskeletal motor activity 10/980 153/18639 0.065359477124183 1.24309723889556 0.285078160381315 0.734152896895968 GO:0016779 nucleotidyltransferase activity 9/980 136/18639 0.0661764705882353 1.25863595438175 0.287168862471056 0.737554343826465 GO:0030159 signaling receptor complex adaptor activity 4/980 52/18639 0.0769230769230769 1.46302982731554 0.291657906345895 0.745647824244496 GO:0015631 tubulin binding 23/980 385/18639 0.0597402597402597 1.13622316459051 0.292932665591419 0.745647824244496 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/980 36/18639 0.0833333333333333 1.58494897959184 0.29343343396678 0.745647824244496 GO:0045505 dynein intermediate chain binding 3/980 36/18639 0.0833333333333333 1.58494897959184 0.29343343396678 0.745647824244496 GO:0032182 ubiquitin-like protein binding 8/980 120/18639 0.0666666666666667 1.26795918367347 0.296487566325059 0.751415578146577 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/980 86/18639 0.0697674418604651 1.32693402942572 0.298278195692307 0.753218316399009 GO:0140030 modification-dependent protein binding 11/980 173/18639 0.0635838150289017 1.20932523298337 0.301910018633151 0.753218316399009 GO:0005123 death receptor binding 2/980 21/18639 0.0952380952380952 1.81137026239067 0.303458378167245 0.753218316399009 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/980 21/18639 0.0952380952380952 1.81137026239067 0.303458378167245 0.753218316399009 GO:0019200 carbohydrate kinase activity 2/980 21/18639 0.0952380952380952 1.81137026239067 0.303458378167245 0.753218316399009 GO:0005544 calcium-dependent phospholipid binding 4/980 53/18639 0.0754716981132075 1.4354254909511 0.303646414064897 0.753218316399009 GO:0016860 intramolecular oxidoreductase activity 4/980 53/18639 0.0754716981132075 1.4354254909511 0.303646414064897 0.753218316399009 GO:0051018 protein kinase A binding 4/980 53/18639 0.0754716981132075 1.4354254909511 0.303646414064897 0.753218316399009 GO:0003697 single-stranded DNA binding 8/980 121/18639 0.0661157024793388 1.25748018215551 0.304275040131959 0.753218316399009 GO:0097110 scaffold protein binding 5/980 70/18639 0.0714285714285714 1.358527696793 0.307134643745777 0.758337599764057 GO:0140097 catalytic activity, acting on DNA 20/980 336/18639 0.0595238095238095 1.13210641399417 0.31547660416144 0.776418343451973 GO:0004713 protein tyrosine kinase activity 9/980 140/18639 0.0642857142857143 1.2226749271137 0.316253076648773 0.776418343451973 GO:0004197 cysteine-type endopeptidase activity 6/980 88/18639 0.0681818181818182 1.29677643784787 0.316888906356703 0.776418343451973 GO:0140658 ATP-dependent chromatin remodeler activity 10/980 158/18639 0.0632911392405063 1.20375871867734 0.319283696521751 0.78029025833632 GO:0033691 sialic acid binding 2/980 22/18639 0.0909090909090909 1.72903525046382 0.323180915622343 0.785805373518286 GO:0070034 telomerase RNA binding 2/980 22/18639 0.0909090909090909 1.72903525046382 0.323180915622343 0.785805373518286 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/980 89/18639 0.0674157303370786 1.28220591607429 0.326261408091267 0.789288961998571 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/980 89/18639 0.0674157303370786 1.28220591607429 0.326261408091267 0.789288961998571 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 28/980 484/18639 0.0578512396694215 1.10029515938607 0.327328387362992 0.789875554392308 GO:0140793 histone H2AXY142 phosphatase activity 6/980 90/18639 0.0666666666666667 1.26795918367347 0.33567038450849 0.798932858930837 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/980 39/18639 0.0769230769230769 1.46302982731554 0.337309573667715 0.798932858930837 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/980 39/18639 0.0769230769230769 1.46302982731554 0.337309573667715 0.798932858930837 GO:0043539 protein serine/threonine kinase activator activity 5/980 73/18639 0.0684931506849315 1.30269779144535 0.338589433965952 0.798932858930837 GO:0030170 pyridoxal phosphate binding 4/980 56/18639 0.0714285714285714 1.358527696793 0.339871319142006 0.798932858930837 GO:0003887 DNA-directed DNA polymerase activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0004602 glutathione peroxidase activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0016493 C-C chemokine receptor activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0016849 phosphorus-oxygen lyase activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0017134 fibroblast growth factor binding 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0031681 G-protein beta-subunit binding 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0099186 structural constituent of postsynapse 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/980 23/18639 0.0869565217391304 1.65385980479148 0.342757207745902 0.798932858930837 GO:0008083 growth factor activity 10/980 162/18639 0.0617283950617284 1.17403628117914 0.347254000408284 0.807449835900816 GO:0070279 vitamin B6 binding 4/980 57/18639 0.0701754385964912 1.33469387755102 0.351989906581299 0.816480219140156 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 8/980 128/18639 0.0625 1.18871173469388 0.359819895743464 0.829995006243838 GO:0016829 lyase activity 12/980 200/18639 0.06 1.14116326530612 0.361166075023794 0.829995006243838 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/980 24/18639 0.0833333333333333 1.58494897959184 0.362148134248355 0.829995006243838 GO:0050699 WW domain binding 2/980 24/18639 0.0833333333333333 1.58494897959184 0.362148134248355 0.829995006243838 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/980 24/18639 0.0833333333333333 1.58494897959184 0.362148134248355 0.829995006243838 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/980 41/18639 0.0731707317073171 1.391662518666 0.366501007460431 0.830983791982387 GO:1902936 phosphatidylinositol bisphosphate binding 7/980 111/18639 0.0630630630630631 1.19942084942085 0.366533175189541 0.830983791982387 GO:0051536 iron-sulfur cluster binding 5/980 76/18639 0.0657894736842105 1.25127551020408 0.370273609933851 0.830983791982387 GO:0031593 polyubiquitin modification-dependent protein binding 4/980 59/18639 0.0677966101694915 1.28945001729505 0.376219576515727 0.830983791982387 GO:0051540 metal cluster binding 5/980 77/18639 0.0649350649350649 1.23502517890273 0.380847955806425 0.830983791982387 GO:0004520 DNA endonuclease activity 3/980 42/18639 0.0714285714285714 1.358527696793 0.381019769964986 0.830983791982387 GO:0019894 kinesin binding 3/980 42/18639 0.0714285714285714 1.358527696793 0.381019769964986 0.830983791982387 GO:0004709 MAP kinase kinase kinase activity 2/980 25/18639 0.08 1.52155102040816 0.38131908450439 0.830983791982387 GO:0008139 nuclear localization sequence binding 2/980 25/18639 0.08 1.52155102040816 0.38131908450439 0.830983791982387 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/980 25/18639 0.08 1.52155102040816 0.38131908450439 0.830983791982387 GO:0042974 nuclear retinoic acid receptor binding 2/980 25/18639 0.08 1.52155102040816 0.38131908450439 0.830983791982387 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/980 25/18639 0.08 1.52155102040816 0.38131908450439 0.830983791982387 GO:0016247 channel regulator activity 10/980 168/18639 0.0595238095238095 1.13210641399417 0.389843119933177 0.830983791982387 GO:0019842 vitamin binding 9/980 150/18639 0.06 1.14116326530612 0.391076338962203 0.830983791982387 GO:0048156 tau protein binding 3/980 43/18639 0.0697674418604651 1.32693402942572 0.395463584832802 0.830983791982387 GO:0000510 H3-H4 histone complex chaperone activity 9/980 151/18639 0.0596026490066225 1.1336058926882 0.398642715323161 0.830983791982387 GO:0140584 chromatin extrusion motor activity 9/980 151/18639 0.0596026490066225 1.1336058926882 0.398642715323161 0.830983791982387 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 9/980 151/18639 0.0596026490066225 1.1336058926882 0.398642715323161 0.830983791982387 GO:0140849 ATP-dependent H2AZ histone chaperone activity 9/980 151/18639 0.0596026490066225 1.1336058926882 0.398642715323161 0.830983791982387 GO:0001637 G protein-coupled chemoattractant receptor activity 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0004950 chemokine receptor activity 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0005160 transforming growth factor beta receptor binding 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0008143 poly(A) binding 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0030247 polysaccharide binding 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0030507 spectrin binding 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0034237 protein kinase A regulatory subunit binding 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0120014 phospholipid transfer activity 2/980 26/18639 0.0769230769230769 1.46302982731554 0.400239592293971 0.830983791982387 GO:0016835 carbon-oxygen lyase activity 5/980 79/18639 0.0632911392405063 1.20375871867734 0.401969844610563 0.830983791982387 GO:0141108 transporter regulator activity 10/980 170/18639 0.0588235294117647 1.118787515006 0.404129319855623 0.830983791982387 GO:0015616 DNA translocase activity 9/980 152/18639 0.0592105263157895 1.12614795918367 0.406212763565359 0.830983791982387 GO:0046906 tetrapyrrole binding 9/980 152/18639 0.0592105263157895 1.12614795918367 0.406212763565359 0.830983791982387 GO:0001223 transcription coactivator binding 3/980 44/18639 0.0681818181818182 1.29677643784787 0.409816107128065 0.830983791982387 GO:0019205 nucleobase-containing compound kinase activity 3/980 44/18639 0.0681818181818182 1.29677643784787 0.409816107128065 0.830983791982387 GO:0004725 protein tyrosine phosphatase activity 6/980 98/18639 0.0612244897959184 1.16445231153686 0.411538892668536 0.830983791982387 GO:0061775 cohesin loader activity 9/980 153/18639 0.0588235294117647 1.118787515006 0.413783676264362 0.830983791982387 GO:0000182 rDNA binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0003796 lysozyme activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0004382 GDP phosphatase activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0004955 prostaglandin receptor activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0005381 iron ion transmembrane transporter activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0005528 FK506 binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0031419 cobalamin binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0031434 mitogen-activated protein kinase kinase binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0032356 oxidized DNA binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0035256 G protein-coupled glutamate receptor binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0043422 protein kinase B binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0045322 unmethylated CpG binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0047429 nucleoside triphosphate diphosphatase activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0051880 G-quadruplex DNA binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0099122 RNA polymerase II C-terminal domain binding 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:1990757 ubiquitin ligase activator activity 1/980 10/18639 0.1 1.9019387755102 0.417391557244601 0.830983791982387 GO:0140996 histone H3 kinase activity 20/980 357/18639 0.0560224089635854 1.06551191905334 0.417619795578455 0.830983791982387 GO:0008266 poly(U) RNA binding 2/980 27/18639 0.0740740740740741 1.40884353741497 0.418882996423559 0.830983791982387 GO:0008320 protein transmembrane transporter activity 2/980 27/18639 0.0740740740740741 1.40884353741497 0.418882996423559 0.830983791982387 GO:0035255 ionotropic glutamate receptor binding 2/980 27/18639 0.0740740740740741 1.40884353741497 0.418882996423559 0.830983791982387 GO:0005506 iron ion binding 9/980 154/18639 0.0584415584415584 1.11152266101246 0.421352682444705 0.830983791982387 GO:0030971 receptor tyrosine kinase binding 5/980 81/18639 0.0617283950617284 1.17403628117914 0.423007498886023 0.830983791982387 GO:0044325 transmembrane transporter binding 8/980 136/18639 0.0588235294117647 1.118787515006 0.424345909325308 0.830983791982387 GO:0035091 phosphatidylinositol binding 16/980 284/18639 0.0563380281690141 1.07151480310434 0.424643811252881 0.830983791982387 GO:0035402 histone H3T11 kinase activity 14/980 247/18639 0.0566801619433198 1.07802197802198 0.425380649846008 0.830983791982387 GO:0008094 ATP-dependent activity, acting on DNA 12/980 210/18639 0.0571428571428571 1.0868221574344 0.425768435265818 0.830983791982387 GO:0004386 helicase activity 9/980 155/18639 0.0580645161290323 1.10435154707044 0.428917049863437 0.830983791982387 GO:0035173 histone kinase activity 20/980 360/18639 0.0555555555555556 1.05663265306122 0.432518429621881 0.830983791982387 GO:0004536 DNA nuclease activity 4/980 64/18639 0.0625 1.18871173469388 0.436237663241049 0.830983791982387 GO:0045499 chemorepellent activity 2/980 28/18639 0.0714285714285714 1.358527696793 0.437226125520112 0.830983791982387 GO:0051393 alpha-actinin binding 2/980 28/18639 0.0714285714285714 1.358527696793 0.437226125520112 0.830983791982387 GO:0004180 carboxypeptidase activity 3/980 46/18639 0.0652173913043478 1.24039485359361 0.438187297724816 0.830983791982387 GO:0030291 protein serine/threonine kinase inhibitor activity 3/980 46/18639 0.0652173913043478 1.24039485359361 0.438187297724816 0.830983791982387 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0003953 NAD+ nucleosidase activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0004954 prostanoid receptor activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0005114 type II transforming growth factor beta receptor binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0008199 ferric iron binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0008526 phosphatidylinositol transfer activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0015217 ADP transmembrane transporter activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0019107 myristoyltransferase activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0031731 CCR6 chemokine receptor binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0032050 clathrin heavy chain binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0034511 U3 snoRNA binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0034713 type I transforming growth factor beta receptor binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0070697 activin receptor binding 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0140537 transcription regulator activator activity 1/980 11/18639 0.0909090909090909 1.72903525046382 0.448040345365289 0.830983791982387 GO:0030295 protein kinase activator activity 8/980 139/18639 0.0575539568345324 1.09464102187638 0.448486700259564 0.830983791982387 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/980 29/18639 0.0689655172413793 1.31168191414497 0.455249005398135 0.830983791982387 GO:0043236 laminin binding 2/980 29/18639 0.0689655172413793 1.31168191414497 0.455249005398135 0.830983791982387 GO:0097472 cyclin-dependent protein kinase activity 2/980 29/18639 0.0689655172413793 1.31168191414497 0.455249005398135 0.830983791982387 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/980 48/18639 0.0625 1.18871173469388 0.466023829773964 0.830983791982387 GO:0003689 DNA clamp loader activity 9/980 160/18639 0.05625 1.06984056122449 0.466576651632624 0.830983791982387 GO:0099106 ion channel regulator activity 9/980 160/18639 0.05625 1.06984056122449 0.466576651632624 0.830983791982387 GO:0020037 heme binding 8/980 142/18639 0.0563380281690141 1.07151480310434 0.472461868915508 0.830983791982387 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/980 30/18639 0.0666666666666667 1.26795918367347 0.472934587501207 0.830983791982387 GO:0015215 nucleotide transmembrane transporter activity 2/980 30/18639 0.0666666666666667 1.26795918367347 0.472934587501207 0.830983791982387 GO:0033612 receptor serine/threonine kinase binding 2/980 30/18639 0.0666666666666667 1.26795918367347 0.472934587501207 0.830983791982387 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/980 30/18639 0.0666666666666667 1.26795918367347 0.472934587501207 0.830983791982387 GO:0098918 structural constituent of synapse 2/980 30/18639 0.0666666666666667 1.26795918367347 0.472934587501207 0.830983791982387 GO:0005178 integrin binding 9/980 161/18639 0.0559006211180124 1.06319558879452 0.474058236862153 0.830983791982387 GO:0000340 RNA 7-methylguanosine cap binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0003720 telomerase activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0004000 adenosine deaminase activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0005049 nuclear export signal receptor activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0005095 GTPase inhibitor activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0005165 neurotrophin receptor binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0005527 macrolide binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0008603 cAMP-dependent protein kinase regulator activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0010853 cyclase activator activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0016208 AMP binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0016840 carbon-nitrogen lyase activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0017166 vinculin binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0031543 peptidyl-proline dioxygenase activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0042301 phosphate ion binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0045295 gamma-catenin binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0070008 serine-type exopeptidase activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0070410 co-SMAD binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:1990459 transferrin receptor binding 1/980 12/18639 0.0833333333333333 1.58494897959184 0.477078377442915 0.830983791982387 GO:0005548 phospholipid transporter activity 4/980 68/18639 0.0588235294117647 1.118787515006 0.483044214335797 0.838326734300169 GO:0030145 manganese ion binding 4/980 68/18639 0.0588235294117647 1.118787515006 0.483044214335797 0.838326734300169 GO:0070273 phosphatidylinositol-4-phosphate binding 2/980 31/18639 0.0645161290322581 1.22705727452271 0.490268497014362 0.843636753056923 GO:0002039 p53 binding 4/980 69/18639 0.0579710144927536 1.10257320319432 0.494509068345012 0.843636753056923 GO:0008080 N-acetyltransferase activity 4/980 69/18639 0.0579710144927536 1.10257320319432 0.494509068345012 0.843636753056923 GO:0141003 histone H2AX kinase activity 19/980 354/18639 0.0536723163841808 1.02081459702525 0.496938394696116 0.843636753056923 GO:0004519 endonuclease activity 7/980 127/18639 0.0551181102362205 1.04831271091114 0.504380226400886 0.843636753056923 GO:0003964 RNA-directed DNA polymerase activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0005172 vascular endothelial growth factor receptor binding 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0005542 folic acid binding 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0008253 5'-nucleotidase activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0019104 DNA N-glycosylase activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0019855 calcium channel inhibitor activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0031432 titin binding 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0051011 microtubule minus-end binding 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0070700 BMP receptor binding 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0140666 annealing activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/980 13/18639 0.0769230769230769 1.46302982731554 0.504590225303867 0.843636753056923 GO:0005048 signal sequence binding 3/980 51/18639 0.0588235294117647 1.118787515006 0.506575811543928 0.843636753056923 GO:0016830 carbon-carbon lyase activity 3/980 51/18639 0.0588235294117647 1.118787515006 0.506575811543928 0.843636753056923 GO:0022884 macromolecule transmembrane transporter activity 2/980 32/18639 0.0625 1.18871173469388 0.507238799332764 0.843636753056923 GO:0070717 poly-purine tract binding 2/980 32/18639 0.0625 1.18871173469388 0.507238799332764 0.843636753056923 GO:0140142 nucleocytoplasmic carrier activity 2/980 32/18639 0.0625 1.18871173469388 0.507238799332764 0.843636753056923 GO:0003714 transcription corepressor activity 11/980 204/18639 0.053921568627451 1.02555522208884 0.509872291041461 0.846547062075771 GO:0005080 protein kinase C binding 3/980 52/18639 0.0576923076923077 1.09727237048666 0.519734050637685 0.854400792679982 GO:0030296 protein tyrosine kinase activator activity 2/980 33/18639 0.0606060606060606 1.15269016697588 0.523835783655825 0.854400792679982 GO:0005518 collagen binding 4/980 72/18639 0.0555555555555556 1.05663265306122 0.528225882337139 0.854400792679982 GO:0005516 calmodulin binding 11/980 207/18639 0.0531400966183575 1.01069210292813 0.529609440443455 0.854400792679982 GO:0004065 arylsulfatase activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0005347 ATP transmembrane transporter activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0008195 phosphatidate phosphatase activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0008494 translation activator activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0034236 protein kinase A catalytic subunit binding 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0042043 neurexin family protein binding 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0043176 amine binding 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0061665 SUMO ligase activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0061783 peptidoglycan muralytic activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0071933 Arp2/3 complex binding 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:1901474 azole transmembrane transporter activity 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:1901612 cardiolipin binding 1/980 14/18639 0.0714285714285714 1.358527696793 0.5306560246812 0.854400792679982 GO:0005246 calcium channel regulator activity 3/980 53/18639 0.0566037735849057 1.07656911821332 0.532699308832052 0.856251573592459 GO:0030332 cyclin binding 2/980 34/18639 0.0588235294117647 1.118787515006 0.540051762554346 0.866615726175985 GO:0004518 nuclease activity 11/980 209/18639 0.0526315789473684 1.00102040816327 0.542623397854521 0.869286312950889 GO:0000774 adenyl-nucleotide exchange factor activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0004129 cytochrome-c oxidase activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0008252 nucleotidase activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0017081 chloride channel regulator activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0042809 nuclear vitamin D receptor binding 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0045504 dynein heavy chain binding 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0051371 muscle alpha-actinin binding 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0061578 K63-linked deubiquitinase activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0140161 monocarboxylate:sodium symporter activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0141050 histone H3K deacetylase activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0141051 histone H4K deacetylase activity 1/980 15/18639 0.0666666666666667 1.26795918367347 0.555351707677841 0.871577560068402 GO:0000175 3'-5'-RNA exonuclease activity 2/980 35/18639 0.0571428571428571 1.0868221574344 0.555880886431935 0.871577560068402 GO:0008374 O-acyltransferase activity 3/980 55/18639 0.0545454545454545 1.03742115027829 0.558024277366397 0.872083617809149 GO:0098632 cell-cell adhesion mediator activity 3/980 55/18639 0.0545454545454545 1.03742115027829 0.558024277366397 0.872083617809149 GO:0004867 serine-type endopeptidase inhibitor activity 5/980 95/18639 0.0526315789473684 1.00102040816327 0.563778715345528 0.874440383437141 GO:0004033 aldo-keto reductase (NADPH) activity 2/980 36/18639 0.0555555555555556 1.05663265306122 0.571318971871062 0.874440383437141 GO:0055106 ubiquitin-protein transferase regulator activity 2/980 36/18639 0.0555555555555556 1.05663265306122 0.571318971871062 0.874440383437141 GO:0140789 histone phosphatase activity 7/980 136/18639 0.0514705882352941 0.978939075630252 0.577622409458477 0.874440383437141 GO:0005159 insulin-like growth factor receptor binding 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0008296 3'-5'-DNA exonuclease activity 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0015378 sodium:chloride symporter activity 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0016722 oxidoreductase activity, acting on metal ions 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0022858 alanine transmembrane transporter activity 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0097027 ubiquitin-protein transferase activator activity 1/980 16/18639 0.0625 1.18871173469388 0.578749223059913 0.874440383437141 GO:0003724 RNA helicase activity 4/980 77/18639 0.051948051948052 0.988020143122184 0.581832805995808 0.874440383437141 GO:1990782 protein tyrosine kinase binding 6/980 117/18639 0.0512820512820513 0.975353218210361 0.583791513080309 0.874440383437141 GO:0019213 deacetylase activity 2/980 37/18639 0.0540540540540541 1.0280750137893 0.586363342918936 0.874440383437141 GO:0022829 wide pore channel activity 2/980 37/18639 0.0540540540540541 1.0280750137893 0.586363342918936 0.874440383437141 GO:0043394 proteoglycan binding 2/980 37/18639 0.0540540540540541 1.0280750137893 0.586363342918936 0.874440383437141 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/980 58/18639 0.0517241379310345 0.983761435608726 0.594417385184565 0.874440383437141 GO:0004674 protein serine/threonine kinase activity 22/980 433/18639 0.0508083140877598 0.966343026818118 0.597458845539022 0.874440383437141 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0004549 tRNA-specific ribonuclease activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0004550 nucleoside diphosphate kinase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0004659 prenyltransferase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0016018 cyclosporin A binding 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0016805 dipeptidase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0019198 transmembrane receptor protein phosphatase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0030169 low-density lipoprotein particle binding 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0030548 acetylcholine receptor regulator activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0032977 membrane insertase activity 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0070403 NAD+ binding 1/980 17/18639 0.0588235294117647 1.118787515006 0.600916745016702 0.874440383437141 GO:0000146 microfilament motor activity 2/980 38/18639 0.0526315789473684 1.00102040816327 0.601012684429206 0.874440383437141 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/980 38/18639 0.0526315789473684 1.00102040816327 0.601012684429206 0.874440383437141 GO:0008186 ATP-dependent activity, acting on RNA 4/980 79/18639 0.0506329113924051 0.963006974941875 0.602267255602231 0.874440383437141 GO:0015459 potassium channel regulator activity 3/980 59/18639 0.0508474576271186 0.96708751297129 0.606106553506111 0.874440383437141 GO:0036002 pre-mRNA binding 3/980 59/18639 0.0508474576271186 0.96708751297129 0.606106553506111 0.874440383437141 GO:0070888 E-box binding 3/980 59/18639 0.0508474576271186 0.96708751297129 0.606106553506111 0.874440383437141 GO:0000049 tRNA binding 4/980 80/18639 0.05 0.950969387755102 0.612254862438884 0.874440383437141 GO:0000217 DNA secondary structure binding 2/980 39/18639 0.0512820512820513 0.975353218210361 0.61526690663253 0.874440383437141 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/980 60/18639 0.05 0.950969387755102 0.617569644707633 0.874440383437141 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0008308 voltage-gated monoatomic anion channel activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0008525 phosphatidylcholine transporter activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0015373 monoatomic anion:sodium symporter activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0034185 apolipoprotein binding 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0035615 clathrin adaptor activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0070064 proline-rich region binding 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0099602 neurotransmitter receptor regulator activity 1/980 18/18639 0.0555555555555556 1.05663265306122 0.621918870990477 0.874440383437141 GO:0005539 glycosaminoglycan binding 12/980 242/18639 0.0495867768595041 0.94311013661663 0.624358058270563 0.874440383437141 GO:0106310 protein serine kinase activity 18/980 361/18639 0.0498614958448753 0.948335123523094 0.626295510907173 0.874440383437141 GO:0008238 exopeptidase activity 5/980 102/18639 0.0490196078431373 0.932322929171669 0.627289828296489 0.874440383437141 GO:0015026 coreceptor activity 3/980 61/18639 0.0491803278688525 0.935379725660756 0.628804427656637 0.874440383437141 GO:0004177 aminopeptidase activity 2/980 40/18639 0.05 0.950969387755102 0.629127020162541 0.874440383437141 GO:0004532 RNA exonuclease activity 2/980 40/18639 0.05 0.950969387755102 0.629127020162541 0.874440383437141 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/980 40/18639 0.05 0.950969387755102 0.629127020162541 0.874440383437141 GO:0030331 nuclear estrogen receptor binding 2/980 40/18639 0.05 0.950969387755102 0.629127020162541 0.874440383437141 GO:0071949 FAD binding 2/980 40/18639 0.05 0.950969387755102 0.629127020162541 0.874440383437141 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 12/980 243/18639 0.0493827160493827 0.939229024943311 0.630038501424768 0.874440383437141 GO:0004676 3-phosphoinositide-dependent protein kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0004711 ribosomal protein S6 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0035175 histone H3S10 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0035979 histone H2AXS139 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0044022 histone H3S28 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0044023 histone H4S1 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0044024 histone H2AS1 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0044025 histone H2BS14 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0072354 histone H3T3 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0072371 histone H2AS121 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0072518 Rho-dependent protein serine/threonine kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0140823 histone H2BS36 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0140855 histone H3S57 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0140995 histone H2A kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0140997 histone H4 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0140998 histone H2B kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:1990244 histone H2AT120 kinase activity 12/980 245/18639 0.0489795918367347 0.931561849229488 0.641267381340695 0.874440383437141 GO:0003756 protein disulfide isomerase activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0005520 insulin-like growth factor binding 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0008301 DNA binding, bending 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0042577 lipid phosphatase activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0046624 sphingolipid transporter activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0140036 ubiquitin-modified protein reader activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:1990380 K48-linked deubiquitinase activity 1/980 19/18639 0.0526315789473684 1.00102040816327 0.641816809147897 0.874440383437141 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/980 41/18639 0.0487804878048781 0.927775012444002 0.642595020813932 0.874440383437141 GO:0140318 protein transporter activity 2/980 41/18639 0.0487804878048781 0.927775012444002 0.642595020813932 0.874440383437141 GO:0004677 DNA-dependent protein kinase activity 12/980 246/18639 0.0487804878048781 0.927775012444002 0.646814317352756 0.877688549608981 GO:0140857 histone H3T45 kinase activity 12/980 246/18639 0.0487804878048781 0.927775012444002 0.646814317352756 0.877688549608981 GO:0035403 histone H3T6 kinase activity 12/980 247/18639 0.048582995951417 0.924018838304553 0.652315304329184 0.882734277100958 GO:0004402 histone acetyltransferase activity 2/980 42/18639 0.0476190476190476 0.905685131195335 0.655673783356379 0.882734277100958 GO:0004679 AMP-activated protein kinase activity 12/980 248/18639 0.0483870967741935 0.920292955892034 0.657769672771914 0.882734277100958 GO:0001614 purinergic nucleotide receptor activity 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0001972 retinoic acid binding 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0016502 nucleotide receptor activity 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0030627 pre-mRNA 5'-splice site binding 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0052745 inositol phosphate phosphatase activity 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0061608 nuclear import signal receptor activity 1/980 20/18639 0.05 0.950969387755102 0.66066855603485 0.882734277100958 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 11/980 229/18639 0.0480349344978166 0.913595045004902 0.664058163089669 0.886027465515185 GO:0008200 ion channel inhibitor activity 2/980 43/18639 0.0465116279069767 0.884622686283816 0.668366963772164 0.889299376796851 GO:0008375 acetylglucosaminyltransferase activity 2/980 43/18639 0.0465116279069767 0.884622686283816 0.668366963772164 0.889299376796851 GO:0160215 deacylase activity 3/980 65/18639 0.0461538461538462 0.877817896389325 0.671433561347503 0.892140571110829 GO:0005096 GTPase activator activity 13/980 271/18639 0.0479704797047971 0.912369154303788 0.672909511258905 0.892863312723035 GO:0008373 sialyltransferase activity 1/980 21/18639 0.0476190476190476 0.905685131195335 0.678529064928231 0.894127708667462 GO:0035613 RNA stem-loop binding 1/980 21/18639 0.0476190476190476 0.905685131195335 0.678529064928231 0.894127708667462 GO:0070182 DNA polymerase binding 1/980 21/18639 0.0476190476190476 0.905685131195335 0.678529064928231 0.894127708667462 GO:0140312 cargo adaptor activity 1/980 21/18639 0.0476190476190476 0.905685131195335 0.678529064928231 0.894127708667462 GO:1904047 S-adenosyl-L-methionine binding 1/980 21/18639 0.0476190476190476 0.905685131195335 0.678529064928231 0.894127708667462 GO:0003954 NADH dehydrogenase activity 2/980 44/18639 0.0454545454545455 0.864517625231911 0.680678909326645 0.894365989061214 GO:0016248 channel inhibitor activity 2/980 44/18639 0.0454545454545455 0.864517625231911 0.680678909326645 0.894365989061214 GO:0008235 metalloexopeptidase activity 3/980 66/18639 0.0454545454545455 0.864517625231911 0.681510617969401 0.894365989061214 GO:0016791 phosphatase activity 13/980 273/18639 0.0476190476190476 0.905685131195335 0.683020867050391 0.895121738213782 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/980 130/18639 0.0461538461538462 0.877817896389325 0.685231943336105 0.895485871432487 GO:0050840 extracellular matrix binding 3/980 67/18639 0.0447761194029851 0.851614377094121 0.691355931587496 0.895485871432487 GO:0046915 transition metal ion transmembrane transporter activity 2/980 45/18639 0.0444444444444444 0.84530612244898 0.692614575919521 0.895485871432487 GO:0140303 intramembrane lipid transporter activity 2/980 45/18639 0.0444444444444444 0.84530612244898 0.692614575919521 0.895485871432487 GO:0141110 transporter inhibitor activity 2/980 45/18639 0.0444444444444444 0.84530612244898 0.692614575919521 0.895485871432487 GO:0004407 histone deacetylase activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0015377 chloride:monoatomic cation symporter activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0031683 G-protein beta/gamma-subunit complex binding 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0033558 protein lysine deacetylase activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0034062 5'-3' RNA polymerase activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0097747 RNA polymerase activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0140035 ubiquitin-like protein reader activity 1/980 22/18639 0.0454545454545455 0.864517625231911 0.695450405371368 0.895485871432487 GO:0008017 microtubule binding 13/980 276/18639 0.0471014492753623 0.895840727595386 0.697843566916921 0.897361257860953 GO:0005179 hormone activity 6/980 132/18639 0.0454545454545455 0.864517625231911 0.699305584950106 0.898035858421182 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/980 68/18639 0.0441176470588235 0.839090636254502 0.700970318537574 0.898968628057559 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/980 46/18639 0.0434782608695652 0.826929902395741 0.704179452201098 0.900214699593231 GO:0030276 clathrin binding 2/980 46/18639 0.0434782608695652 0.826929902395741 0.704179452201098 0.900214699593231 GO:0004721 phosphoprotein phosphatase activity 8/980 175/18639 0.0457142857142857 0.869457725947522 0.706943063981087 0.900214699593231 GO:0000295 adenine nucleotide transmembrane transporter activity 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0005158 insulin receptor binding 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0005283 amino acid:sodium symporter activity 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0008171 O-methyltransferase activity 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0140102 catalytic activity, acting on a rRNA 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0140103 catalytic activity, acting on a glycoprotein 1/980 23/18639 0.0434782608695652 0.826929902395741 0.711481914354344 0.900214699593231 GO:0043495 protein-membrane adaptor activity 2/980 47/18639 0.0425531914893617 0.809335649153278 0.715379489971824 0.900214699593231 GO:0061733 protein-lysine-acetyltransferase activity 2/980 47/18639 0.0425531914893617 0.809335649153278 0.715379489971824 0.900214699593231 GO:0061749 forked DNA-dependent helicase activity 2/980 47/18639 0.0425531914893617 0.809335649153278 0.715379489971824 0.900214699593231 GO:0140359 ABC-type transporter activity 2/980 47/18639 0.0425531914893617 0.809335649153278 0.715379489971824 0.900214699593231 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/980 47/18639 0.0425531914893617 0.809335649153278 0.715379489971824 0.900214699593231 GO:0052689 carboxylic ester hydrolase activity 4/980 92/18639 0.0434782608695652 0.826929902395741 0.719457027143617 0.900214699593231 GO:0009378 four-way junction helicase activity 2/980 48/18639 0.0416666666666667 0.792474489795918 0.726221040415209 0.900214699593231 GO:0032266 phosphatidylinositol-3-phosphate binding 2/980 48/18639 0.0416666666666667 0.792474489795918 0.726221040415209 0.900214699593231 GO:0036121 double-stranded DNA helicase activity 2/980 48/18639 0.0416666666666667 0.792474489795918 0.726221040415209 0.900214699593231 GO:0043138 3'-5' DNA helicase activity 2/980 48/18639 0.0416666666666667 0.792474489795918 0.726221040415209 0.900214699593231 GO:0005315 phosphate transmembrane transporter activity 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0015295 solute:proton symporter activity 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0070300 phosphatidic acid binding 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0070840 dynein complex binding 1/980 24/18639 0.0416666666666667 0.792474489795918 0.726670339576343 0.900214699593231 GO:0051213 dioxygenase activity 4/980 93/18639 0.043010752688172 0.818038183015142 0.727313337667182 0.900214699593231 GO:0016410 N-acyltransferase activity 4/980 94/18639 0.0425531914893617 0.809335649153278 0.735004298256833 0.904875711287715 GO:0005251 delayed rectifier potassium channel activity 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0015271 outward rectifier potassium channel activity 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0017025 TBP-class protein binding 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0047617 fatty acyl-CoA hydrolase activity 1/980 25/18639 0.04 0.760775510204082 0.741059975204341 0.904875711287715 GO:0008276 protein methyltransferase activity 4/980 95/18639 0.0421052631578947 0.800816326530612 0.742530697505682 0.904875711287715 GO:0004521 RNA endonuclease activity 3/980 73/18639 0.0410958904109589 0.781618674867207 0.745628385003302 0.904875711287715 GO:0015605 organophosphate ester transmembrane transporter activity 2/980 50/18639 0.04 0.760775510204082 0.746855735868541 0.904875711287715 GO:0003678 DNA helicase activity 3/980 74/18639 0.0405405405405405 0.771056260341975 0.7538909429486 0.904875711287715 GO:0031491 nucleosome binding 3/980 74/18639 0.0405405405405405 0.771056260341975 0.7538909429486 0.904875711287715 GO:0035064 methylated histone binding 3/980 74/18639 0.0405405405405405 0.771056260341975 0.7538909429486 0.904875711287715 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0004435 phosphatidylinositol phospholipase C activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0004529 DNA exonuclease activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0005112 Notch binding 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0005227 calcium-activated cation channel activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0015216 purine nucleotide transmembrane transporter activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0016289 acyl-CoA hydrolase activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0050681 nuclear androgen receptor binding 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0050750 low-density lipoprotein particle receptor binding 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0070006 metalloaminopeptidase activity 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0097602 cullin family protein binding 1/980 26/18639 0.0384615384615385 0.731514913657771 0.754692790520756 0.904875711287715 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/980 52/18639 0.0384615384615385 0.731514913657771 0.766140240881759 0.91493361144903 GO:0004364 glutathione transferase activity 1/980 27/18639 0.037037037037037 0.704421768707483 0.767608551832187 0.91493361144903 GO:0005044 scavenger receptor activity 1/980 27/18639 0.037037037037037 0.704421768707483 0.767608551832187 0.91493361144903 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/980 27/18639 0.037037037037037 0.704421768707483 0.767608551832187 0.91493361144903 GO:0004540 RNA nuclease activity 5/980 121/18639 0.0413223140495868 0.785925113847192 0.768869367641842 0.91493361144903 GO:0098631 cell adhesion mediator activity 3/980 76/18639 0.0394736842105263 0.750765306122449 0.769766691887179 0.91493361144903 GO:0140034 methylation-dependent protein binding 3/980 76/18639 0.0394736842105263 0.750765306122449 0.769766691887179 0.91493361144903 GO:0034212 protein N-acetyltransferase activity 2/980 53/18639 0.0377358490566038 0.717712745475549 0.775294787236649 0.92036233726482 GO:0051537 2 iron, 2 sulfur cluster binding 1/980 28/18639 0.0357142857142857 0.679263848396501 0.779844937991893 0.923475217053441 GO:0051959 dynein light intermediate chain binding 1/980 28/18639 0.0357142857142857 0.679263848396501 0.779844937991893 0.923475217053441 GO:0050661 NADP binding 2/980 54/18639 0.037037037037037 0.704421768707483 0.784134404284527 0.927408344820465 GO:0004629 phospholipase C activity 1/980 29/18639 0.0344827586206897 0.655840957072484 0.791437649870242 0.933740478541492 GO:0005416 amino acid:monoatomic cation symporter activity 1/980 29/18639 0.0344827586206897 0.655840957072484 0.791437649870242 0.933740478541492 GO:0042578 phosphoric ester hydrolase activity 16/980 363/18639 0.0440771349862259 0.838320121437005 0.800329157583621 0.935714910018148 GO:0016769 transferase activity, transferring nitrogenous groups 1/980 30/18639 0.0333333333333333 0.633979591836735 0.802420514089864 0.935714910018148 GO:0022839 monoatomic ion-gated channel activity 1/980 30/18639 0.0333333333333333 0.633979591836735 0.802420514089864 0.935714910018148 GO:0031624 ubiquitin conjugating enzyme binding 1/980 30/18639 0.0333333333333333 0.633979591836735 0.802420514089864 0.935714910018148 GO:0048019 receptor antagonist activity 1/980 30/18639 0.0333333333333333 0.633979591836735 0.802420514089864 0.935714910018148 GO:0033192 calmodulin-dependent protein phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0140791 histone H2AXS140 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/980 81/18639 0.037037037037037 0.704421768707483 0.805808769065733 0.935714910018148 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/980 57/18639 0.0350877192982456 0.66734693877551 0.808841622696502 0.937048022755757 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/980 82/18639 0.0365853658536585 0.695831259333001 0.812418287212159 0.937048022755757 GO:0033549 MAP kinase phosphatase activity 3/980 82/18639 0.0365853658536585 0.695831259333001 0.812418287212159 0.937048022755757 GO:0005184 neuropeptide hormone activity 1/980 31/18639 0.032258064516129 0.613528637261356 0.812825581325714 0.937048022755757 GO:0005452 solute:inorganic anion antiporter activity 1/980 31/18639 0.032258064516129 0.613528637261356 0.812825581325714 0.937048022755757 GO:0070325 lipoprotein particle receptor binding 1/980 31/18639 0.032258064516129 0.613528637261356 0.812825581325714 0.937048022755757 GO:0008013 beta-catenin binding 4/980 106/18639 0.0377358490566038 0.717712745475549 0.814822439993109 0.93713498720265 GO:0008408 3'-5' exonuclease activity 2/980 58/18639 0.0344827586206897 0.655840957072484 0.816499631179071 0.93713498720265 GO:0017116 single-stranded DNA helicase activity 2/980 58/18639 0.0344827586206897 0.655840957072484 0.816499631179071 0.93713498720265 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/980 83/18639 0.036144578313253 0.687447750184411 0.818836361913864 0.93713498720265 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/980 130/18639 0.0384615384615385 0.731514913657771 0.819827662583236 0.93713498720265 GO:0031369 translation initiation factor binding 1/980 32/18639 0.03125 0.594355867346939 0.822683219454519 0.93713498720265 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/980 32/18639 0.03125 0.594355867346939 0.822683219454519 0.93713498720265 GO:0071813 lipoprotein particle binding 1/980 32/18639 0.03125 0.594355867346939 0.822683219454519 0.93713498720265 GO:0071814 protein-lipid complex binding 1/980 32/18639 0.03125 0.594355867346939 0.822683219454519 0.93713498720265 GO:0160041 neuropeptide activity 1/980 32/18639 0.03125 0.594355867346939 0.822683219454519 0.93713498720265 GO:0017018 myosin phosphatase activity 3/980 84/18639 0.0357142857142857 0.679263848396501 0.825066643038231 0.938733781509056 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/980 60/18639 0.0333333333333333 0.633979591836735 0.830996058214309 0.943239601622403 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/980 60/18639 0.0333333333333333 0.633979591836735 0.830996058214309 0.943239601622403 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/980 33/18639 0.0303030303030303 0.576345083487941 0.832022201823228 0.943286709285979 GO:0050660 flavin adenine dinucleotide binding 3/980 86/18639 0.0348837209302326 0.663467014712862 0.836978661977008 0.947784347723373 GO:0016831 carboxy-lyase activity 1/980 34/18639 0.0294117647058824 0.559393757503001 0.840869790891982 0.949944881691649 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/980 34/18639 0.0294117647058824 0.559393757503001 0.840869790891982 0.949944881691649 GO:0008081 phosphoric diester hydrolase activity 3/980 87/18639 0.0344827586206897 0.655840957072484 0.84266790750623 0.950854953346253 GO:0019838 growth factor binding 5/980 136/18639 0.0367647058823529 0.699242196878751 0.848482447222493 0.954909907463627 GO:0005343 organic acid:sodium symporter activity 1/980 35/18639 0.0285714285714286 0.543411078717201 0.849251817493748 0.954909907463627 GO:0016229 steroid dehydrogenase activity 1/980 35/18639 0.0285714285714286 0.543411078717201 0.849251817493748 0.954909907463627 GO:1901682 sulfur compound transmembrane transporter activity 2/980 63/18639 0.0317460317460317 0.603790087463557 0.850807721075632 0.95553786259139 GO:0008237 metallopeptidase activity 7/980 184/18639 0.0380434782608696 0.723563664596273 0.856275454148052 0.960456912503656 GO:0016409 palmitoyltransferase activity 1/980 36/18639 0.0277777777777778 0.528316326530612 0.85719275594011 0.960456912503656 GO:0120013 lipid transfer activity 2/980 65/18639 0.0307692307692308 0.585211930926217 0.862815207252544 0.965627299705534 GO:0030551 cyclic nucleotide binding 1/980 37/18639 0.027027027027027 0.51403750689465 0.864715795190699 0.966625124612239 GO:0005501 retinoid binding 1/980 38/18639 0.0263157894736842 0.500510204081633 0.87184290629236 0.972323054980304 GO:0019840 isoprenoid binding 1/980 38/18639 0.0263157894736842 0.500510204081633 0.87184290629236 0.972323054980304 GO:0022853 active monoatomic ion transmembrane transporter activity 4/980 118/18639 0.0338983050847458 0.644725008647527 0.873780881711371 0.973223250707719 GO:0015399 primary active transmembrane transporter activity 6/980 166/18639 0.036144578313253 0.687447750184411 0.874681856846917 0.973223250707719 GO:0032934 sterol binding 2/980 68/18639 0.0294117647058824 0.559393757503001 0.879172209099299 0.977084659300613 GO:0071855 neuropeptide receptor binding 1/980 40/18639 0.025 0.475484693877551 0.884991518748046 0.982309863160127 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/980 70/18639 0.0285714285714286 0.543411078717201 0.889055659061622 0.982309863160127 GO:0016782 transferase activity, transferring sulphur-containing groups 2/980 70/18639 0.0285714285714286 0.543411078717201 0.889055659061622 0.982309863160127 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/980 122/18639 0.0327868852459016 0.623586483773837 0.889461552238992 0.982309863160127 GO:0008236 serine-type peptidase activity 7/980 194/18639 0.0360824742268041 0.686266568483063 0.889734330025726 0.982309863160127 GO:0001727 lipid kinase activity 1/980 41/18639 0.024390243902439 0.463887506222001 0.891051431196399 0.982309863160127 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/980 41/18639 0.024390243902439 0.463887506222001 0.891051431196399 0.982309863160127 GO:0140299 molecular sensor activity 2/980 71/18639 0.028169014084507 0.53575740155217 0.893711161571967 0.982915508534256 GO:0008201 heparin binding 6/980 172/18639 0.0348837209302326 0.663467014712862 0.894418280131241 0.982915508534256 GO:0042626 ATPase-coupled transmembrane transporter activity 3/980 98/18639 0.0306122448979592 0.58222615576843 0.894678834490471 0.982915508534256 GO:0008307 structural constituent of muscle 1/980 42/18639 0.0238095238095238 0.452842565597668 0.8967923494364 0.982982918489783 GO:0031492 nucleosomal DNA binding 1/980 42/18639 0.0238095238095238 0.452842565597668 0.8967923494364 0.982982918489783 GO:0017171 serine hydrolase activity 7/980 198/18639 0.0353535353535354 0.672402597402597 0.901154273693226 0.984438889559315 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/980 43/18639 0.0232558139534884 0.442311343141908 0.902231049095072 0.984438889559315 GO:0005245 voltage-gated calcium channel activity 1/980 43/18639 0.0232558139534884 0.442311343141908 0.902231049095072 0.984438889559315 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/980 43/18639 0.0232558139534884 0.442311343141908 0.902231049095072 0.984438889559315 GO:0004252 serine-type endopeptidase activity 6/980 176/18639 0.0340909090909091 0.648388218923933 0.906050012894359 0.986689353702731 GO:0016790 thiolester hydrolase activity 1/980 44/18639 0.0227272727272727 0.432258812615956 0.907383424438524 0.986689353702731 GO:0043014 alpha-tubulin binding 1/980 44/18639 0.0227272727272727 0.432258812615956 0.907383424438524 0.986689353702731 GO:0001653 peptide receptor activity 4/980 128/18639 0.03125 0.594355867346939 0.909784695161159 0.988178841229467 GO:0004722 protein serine/threonine phosphatase activity 3/980 103/18639 0.029126213592233 0.553962750148603 0.912754832574792 0.990282139984882 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 4/980 132/18639 0.0303030303030303 0.576345083487941 0.921419596557631 0.99855200622422 GO:0015101 organic cation transmembrane transporter activity 2/980 81/18639 0.0246913580246914 0.469614512471655 0.931227417083501 0.999996871379601 GO:0031406 carboxylic acid binding 6/980 187/18639 0.0320855614973262 0.61024773545782 0.932499010066227 0.999996871379601 GO:0043177 organic acid binding 6/980 189/18639 0.0317460317460317 0.603790087463557 0.936529144162021 0.999996871379601 GO:0140767 enzyme-substrate adaptor activity 4/980 139/18639 0.0287769784172662 0.547320510938188 0.938579438381507 0.999996871379601 GO:0004527 exonuclease activity 2/980 84/18639 0.0238095238095238 0.452842565597668 0.939777277667724 0.999996871379601 GO:0008146 sulfotransferase activity 1/980 53/18639 0.0188679245283019 0.358856372737774 0.943112072682872 0.999996871379601 GO:0017046 peptide hormone binding 1/980 53/18639 0.0188679245283019 0.358856372737774 0.943112072682872 0.999996871379601 GO:0038064 collagen receptor activity 1/980 53/18639 0.0188679245283019 0.358856372737774 0.943112072682872 0.999996871379601 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/980 53/18639 0.0188679245283019 0.358856372737774 0.943112072682872 0.999996871379601 GO:0016757 glycosyltransferase activity 9/980 267/18639 0.0337078651685393 0.641102958037147 0.945106749045042 0.999996871379601 GO:0015485 cholesterol binding 1/980 54/18639 0.0185185185185185 0.352210884353741 0.946111651331897 0.999996871379601 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/980 54/18639 0.0185185185185185 0.352210884353741 0.946111651331897 0.999996871379601 GO:1901681 sulfur compound binding 9/980 275/18639 0.0327272727272727 0.622452690166976 0.955957294956435 0.999996871379601 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/980 91/18639 0.021978021978022 0.418008522090155 0.955968618473667 0.999996871379601 GO:0043178 alcohol binding 2/980 92/18639 0.0217391304347826 0.41346495119787 0.957910181841093 0.999996871379601 GO:0008528 G protein-coupled peptide receptor activity 3/980 122/18639 0.0245901639344262 0.467689862830378 0.958521800537203 0.999996871379601 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 3/980 122/18639 0.0245901639344262 0.467689862830378 0.958521800537203 0.999996871379601 GO:0005319 lipid transporter activity 5/980 178/18639 0.0280898876404494 0.534252465030956 0.960534946189922 0.999996871379601 GO:0042562 hormone binding 2/980 94/18639 0.0212765957446809 0.404667824576639 0.96155006162943 0.999996871379601 GO:0016836 hydro-lyase activity 1/980 61/18639 0.0163934426229508 0.311793241886919 0.963120773821539 0.999996871379601 GO:0003730 mRNA 3'-UTR binding 8/980 262/18639 0.0305343511450382 0.580744664277925 0.96855434512683 0.999996871379601 GO:0015078 proton transmembrane transporter activity 5/980 185/18639 0.027027027027027 0.51403750689465 0.96905316248194 0.999996871379601 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/980 67/18639 0.0149253731343284 0.283871459031374 0.973359130347044 0.999996871379601 GO:0005253 monoatomic anion channel activity 2/980 103/18639 0.0194174757281553 0.369308500099069 0.974507104233714 0.999996871379601 GO:0005201 extracellular matrix structural constituent 4/980 168/18639 0.0238095238095238 0.452842565597668 0.97906573546828 0.999996871379601 GO:0005496 steroid binding 2/980 108/18639 0.0185185185185185 0.352210884353741 0.979762484552622 0.999996871379601 GO:0004175 endopeptidase activity 13/980 405/18639 0.0320987654320988 0.610498866213152 0.982079079085793 0.999996871379601 GO:0022843 voltage-gated monoatomic cation channel activity 3/980 143/18639 0.020979020979021 0.39900813472242 0.982518186026869 0.999996871379601 GO:0005244 voltage-gated monoatomic ion channel activity 4/980 173/18639 0.023121387283237 0.43975463017577 0.982747487424684 0.999996871379601 GO:0022832 voltage-gated channel activity 4/980 175/18639 0.0228571428571429 0.434728862973761 0.984041149187026 0.999996871379601 GO:0015294 solute:monoatomic cation symporter activity 2/980 116/18639 0.0172413793103448 0.327920478536242 0.986059803895389 0.999996871379601 GO:0015370 solute:sodium symporter activity 1/980 79/18639 0.0126582278481013 0.240751743735469 0.986102365659028 0.999996871379601 GO:0033293 monocarboxylic acid binding 1/980 79/18639 0.0126582278481013 0.240751743735469 0.986102365659028 0.999996871379601 GO:0008509 monoatomic anion transmembrane transporter activity 3/980 149/18639 0.0201342281879195 0.382940693055746 0.986433335833368 0.999996871379601 GO:0005254 chloride channel activity 1/980 83/18639 0.0120481927710843 0.22914925006147 0.988813437619147 0.999996871379601 GO:0030165 PDZ domain binding 1/980 83/18639 0.0120481927710843 0.22914925006147 0.988813437619147 0.999996871379601 GO:0015108 chloride transmembrane transporter activity 2/980 121/18639 0.0165289256198347 0.314370045538877 0.988978321585946 0.999996871379601 GO:0008514 organic anion transmembrane transporter activity 7/980 269/18639 0.0260223048327138 0.494928305894849 0.989065691263241 0.999996871379601 GO:0005267 potassium channel activity 2/980 124/18639 0.0161290322580645 0.306764318630678 0.990433633058776 0.999996871379601 GO:0140098 catalytic activity, acting on RNA 11/980 387/18639 0.0284237726098191 0.540602752728999 0.992790994798514 0.999996871379601 GO:0016298 lipase activity 2/980 130/18639 0.0153846153846154 0.292605965463108 0.99280324247477 0.999996871379601 GO:0005262 calcium channel activity 2/980 131/18639 0.0152671755725191 0.290372332138962 0.993137859275617 0.999996871379601 GO:0015103 inorganic anion transmembrane transporter activity 3/980 165/18639 0.0181818181818182 0.345807050092764 0.99318471525999 0.999996871379601 GO:0016874 ligase activity 3/980 167/18639 0.0179640718562874 0.341665648295246 0.993753917708463 0.999996871379601 GO:0015297 antiporter activity 2/980 135/18639 0.0148148148148148 0.281768707482993 0.994330502580413 0.999996871379601 GO:0008168 methyltransferase activity 4/980 204/18639 0.0196078431372549 0.372929171668667 0.995013038150871 0.999996871379601 GO:0005249 voltage-gated potassium channel activity 1/980 98/18639 0.0102040816326531 0.194075385256143 0.995044417018926 0.999996871379601 GO:0008170 N-methyltransferase activity 1/980 98/18639 0.0102040816326531 0.194075385256143 0.995044417018926 0.999996871379601 GO:0140101 catalytic activity, acting on a tRNA 2/980 139/18639 0.0143884892086331 0.273660255469094 0.995319289975207 0.999996871379601 GO:0015171 amino acid transmembrane transporter activity 1/980 102/18639 0.00980392156862745 0.186464585834334 0.996012035673311 0.999996871379601 GO:0008194 UDP-glycosyltransferase activity 2/980 145/18639 0.0137931034482759 0.262336382828994 0.996493296673615 0.999996871379601 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3/980 181/18639 0.0165745856353591 0.315238471079039 0.996629726625883 0.999996871379601 GO:0015293 symporter activity 2/980 146/18639 0.0136986301369863 0.260539558289069 0.996658558002066 0.999996871379601 GO:0015085 calcium ion transmembrane transporter activity 2/980 147/18639 0.0136054421768707 0.258767180341524 0.996816158964407 0.999996871379601 GO:0016741 transferase activity, transferring one-carbon groups 4/980 215/18639 0.0186046511627907 0.353849074513526 0.996837684391069 0.999996871379601 GO:0004620 phospholipase activity 1/980 109/18639 0.00917431192660551 0.174489795918367 0.997273535733622 0.999996871379601 GO:0004222 metalloendopeptidase activity 1/980 110/18639 0.00909090909090909 0.172903525046382 0.997417730821644 0.999996871379601 GO:0015079 potassium ion transmembrane transporter activity 2/980 160/18639 0.0125 0.237742346938776 0.998306933016864 0.999996871379601 GO:0016758 hexosyltransferase activity 3/980 197/18639 0.0152284263959391 0.289635346524397 0.998355640165072 0.999996871379601 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/980 167/18639 0.0119760479041916 0.227777098863498 0.998797979845304 0.999996871379601 GO:0099094 ligand-gated monoatomic cation channel activity 1/980 136/18639 0.00735294117647059 0.13984843937575 0.999371961992665 0.999996871379601 GO:0045182 translation regulator activity 7/980 356/18639 0.0196629213483146 0.373976725521669 0.999546527419736 0.999996871379601 GO:0046943 carboxylic acid transmembrane transporter activity 2/980 188/18639 0.0106382978723404 0.20233391228832 0.999573735340597 0.999996871379601 GO:0005342 organic acid transmembrane transporter activity 2/980 189/18639 0.0105820105820106 0.201263362487852 0.999594393627291 0.999996871379601 GO:0022804 active transmembrane transporter activity 10/980 457/18639 0.0218818380743982 0.416179163131336 0.999718229245841 0.999996871379601 GO:0015291 secondary active transmembrane transporter activity 4/980 287/18639 0.0139372822299652 0.265078574984001 0.999861542426711 0.999996871379601 GO:0015081 sodium ion transmembrane transporter activity 1/980 164/18639 0.00609756097560976 0.1159718765555 0.999863307097067 0.999996871379601 GO:0005261 monoatomic cation channel activity 5/980 341/18639 0.0146627565982405 0.278876653300616 0.999940818591611 0.999996871379601 GO:0015276 ligand-gated monoatomic ion channel activity 1/980 186/18639 0.00537634408602151 0.102254772876893 0.999958819601676 0.999996871379601 GO:0022834 ligand-gated channel activity 1/980 188/18639 0.00531914893617021 0.10116695614416 0.99996307757531 0.999996871379601 GO:0022836 gated channel activity 4/980 318/18639 0.0125786163522013 0.239237581825183 0.999966132469956 0.999996871379601 GO:0005216 monoatomic ion channel activity 7/980 448/18639 0.015625 0.297177933673469 0.999989204717875 0.999996871379601 GO:0046873 metal ion transmembrane transporter activity 7/980 450/18639 0.0155555555555556 0.295857142857143 0.999990079136066 0.999996871379601 GO:0030371 translation repressor activity 3/980 329/18639 0.00911854103343465 0.173429067675702 0.999996871379601 0.999996871379601