category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	50/658	205/9376	3.47542441989769	NFKBIA/GADD45B/JUN/HLA-A/HLA-C/TNFAIP3/ISG15/HLA-B/B2M/TNF/HLA-F/HLA-E/HLA-DPB1/STAT1/HLA-DQA2/OAS1/OAS2/RAC1/TAP1/HLA-DMA/CDKN1A/BID/SYK/IRF7/HLA-DPA1/TAPBP/STAT3/CYCS/STAT2/HLA-DRA/PSMD8/BAX/ICAM1/VIM/SAP30/CDKN1B/CXCL10/BTK/OAS3/PSMD4/TAP2/PSMC1/NFKB2/NFKBIE/CD40/IRF9/IKBKE/BAK1/PSMD12/FAS	9.84483422131818
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	44/658	173/9376	3.62408419277193	NFKBIA/TNF/SOCS3/HLA-DPB1/MX1/TNFSF10/STAT1/IFNGR2/CXCL8/HLA-DQA2/CASP1/OAS1/NLRP3/PYCARD/OAS2/MX2/CALCOCO2/HLA-DMA/BID/IRF7/HLA-DPA1/CYCS/STAT2/HLA-DRA/IFIH1/BAX/ICAM1/IL1B/ACTG1/TLR4/SLC25A6/CXCL10/ADAR/OAS3/PML/RSAD2/DNAJB1/TLR7/CCL5/IRF9/IKBKE/BAK1/IL18/FAS	9.57031556901012
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	45/658	187/9376	3.42896152658355	NFKBIA/JUN/TNFAIP3/TXNIP/TNF/GBP2/CYBA/GBP1/STAT1/GBP4/CXCL8/CASP1/CARD16/OAS1/NLRP3/GBP5/PYCARD/GABARAP/OAS2/PSTPIP1/BIRC3/RHOA/CXCL2/IRF7/CASP4/CTSB/STAT2/MAP1LC3B/GABARAPL1/IL1B/TLR4/VDAC2/TXN/GSDMD/OAS3/RBCK1/CXCL3/RIPK2/NLRC4/AIM2/TXN2/CCL5/IRF9/IKBKE/IL18	9.21716720750869
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/658	180/9376	3.48314758527524	NFKBIA/HLA-A/HLA-C/HLA-B/B2M/TNF/HLA-F/BST2/SOCS3/HLA-E/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/OAS1/OAS2/TAP1/SRSF5/HLA-DMA/SRSF3/BID/SYK/BIRC3/EIF4EBP1/IRF7/HLA-DPA1/TAPBP/SP100/CYCS/SRSF7/STAT2/HLA-DRA/IFIH1/BAX/SRSF9/IL1B/OAS3/TAP2/PML/CCL5/IRF9/IKBKE/BAK1/FAS	9.24122312969364
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	53/658	248/9376	3.04520050985391	NFKBIA/JUN/FOS/TNF/CD14/TNFSF10/ARPC3/CXCL8/RHOB/CASP1/NLRP3/PYCARD/BRK1/DYNLT1/ARPC4/RAC1/S100A10/STX10/RHOG/BIRC3/TUBA1A/RHOA/GAPDH/RRAS/RAB7A/CASP4/RAB5C/DYNLRB1/M6PR/CYCS/ARPC1B/BAX/MYL12A/ARF1/ANXA2/IL1B/DYNLL1/ACTG1/TLR4/ARL8A/PFN1/TXN/GSDMD/DCTN3/RIPK2/VPS41/NLRC4/TXN2/ACBD3/ARPC2/RILP/BAK1/IL18	8.9673489445117
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	39/658	155/9376	3.58529267575252	HLA-A/HLA-C/HLA-B/HLA-F/CYBA/HLA-E/FCGR1A/NCF2/HLA-DPB1/CD14/HLA-DQA2/CORO1A/RAC1/ATP6V1F/TAP1/HLA-DMA/ATP6V0D1/NCF1/TUBA1A/RAB7A/HLA-DPA1/NCF4/RAB5C/ATP6V1G1/M6PR/HLA-DRA/ITGB2/OLR1/LAMP1/ATP6V0E1/ACTG1/TLR4/FCGR3A/SEC61B/TAP2/MSR1/ATP6V1D/MARCO/RILP	8.91613645770164
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/658	275/9376	2.74621718706825	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/TNF/CYBA/MT-CO3/MT-ND2/NCF2/MT-ND5/RAC1/CSNK2B/HSPA1A/NCF1/TUBA1A/COX7A2L/MT-CO2/NDUFB5/PSMB3/NCF4/PSMA5/NDUFB8/CYCS/PSMD8/UQCRH/BAX/MT-ND4/MT-ATP8/NDUFA12/PSMA2/IL1B/HSPA6/SLC25A6/SDHB/VDAC2/UQCRFS1/COX6B1/PSMD4/COX5A/NOTCH1/NDUFV2/SDHD/HSPA8/PSMC1/PPIF/PRNP/PSMD9/NDUFS4/CCL5/COX4I1/PSMA7/SDHC/PSMD12	8.07439889530334
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	62/658	368/9376	2.40068719439672	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/TNF/MT-CO3/MT-ND2/NUP214/MT-ND5/CASP1/RAC1/GPX1/HNRNPA1/SRSF3/BID/TUBA1A/COX7A2L/MT-CO2/NDUFB5/PSMB3/RAB8A/PSMA5/NDUFB8/CYCS/SRSF7/PSMD8/UQCRH/MAP1LC3B/BAX/MT-ND4/MT-ATP8/HNRNPA2B1/CHMP2B/NDUFA12/PSMA2/ACTG1/CHCHD10/SDHB/UQCRFS1/PFN1/COX6B1/NRG1/DCTN3/PSMD4/COX5A/NDUFV2/SDHD/PSMC1/NUP62/PSMD9/NDUFS4/BECN1/COX4I1/CCS/DERL1/SEC13/SMCR8/PSMA7/ULK1/GPX3/SDHC/PSMD12	7.53079856946322
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/658	238/9376	2.81392557022809	NFKBIA/JUN/FOS/ISG15/RPS26/TNF/RPS9/MX1/STAT1/CXCL8/RPL36A/CASP1/OAS1/NLRP3/OAS2/MX2/RPS10/RPL3/SYK/RPS20/STAT3/STAT2/RPL36AL/IFIH1/IL1B/TLR4/RPS4X/RPS3A/ADAM17/CXCL10/ADAR/OAS3/RPS2/RPL29/RPL19/RPL9/HBEGF/C3AR1/TLR7/RPL7/RPL27A/RPL24/IRF9/RPL10A/RPL13/RPS16/IKBKE	7.78704200294188
Human Diseases	Infectious disease: viral	hsa05162	Measles	33/658	136/9376	3.45753620597175	NFKBIA/JUN/FOS/TNFAIP3/MX1/STAT1/OAS1/OAS2/MX2/EIF3H/CSNK2B/HSPA1A/MSN/BID/IRF7/STAT3/CYCS/STAT2/IFIH1/BAX/CDKN1B/IL1B/TLR4/HSPA6/STAT5A/ADAR/OAS3/HSPA8/TLR7/IRF9/IKBKE/BAK1/FAS	7.93091957935024
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	27/658	95/9376	4.04978403455447	CCL3L3/JUN/FOS/CCL3/TNF/HLA-DPB1/CXCL8/HLA-DQA2/ATP6V1F/HLA-DMA/ATP6V0D1/CXCL2/HLA-DPA1/TNFSF13B/ATP6V1G1/HLA-DRA/ICAM1/ITGB2/VEGFA/IL1B/ATP6V0E1/TLR4/CXCL3/ATP6V1D/CCL5/ACP5/IL18	8.20774122657636
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	43/658	216/9376	2.83665428346279	NFKBIA/CCL3L3/JUN/FOS/CCL3/SOD2/TNF/CYBA/NCF2/CD14/TNFSF10/CXCL8/CASP1/NLRP3/PYCARD/RAC1/HSPA1A/BID/NCF1/CALM3/RAP1B/RHOA/CXCL2/IRF7/RAP1A/NCF4/STAT3/CYCS/BAX/ICAM1/OLR1/IL1B/TLR4/HSPA6/CALM1/HSPA8/CXCL3/LDLR/CCL5/CD40/IKBKE/IL18/FAS	7.50233940032391
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	48/658	268/9376	2.55210270834278	MT-ATP6/MT-CO1/MT-ND1/DUSP1/MT-CYB/MT-CO3/UBE2L6/MT-ND2/UBC/MT-ND5/GNAI2/TUBA1A/CALM3/COX7A2L/MT-CO2/NDUFB5/PSMB3/PSMA5/NDUFB8/CYCS/PSMD8/UQCRH/BAX/MT-ND4/MT-ATP8/NDUFA12/PSMA2/SLC25A6/SDHB/VDAC2/UQCRFS1/COX6B1/TXN/PSMD4/PARK7/COX5A/NDUFV2/CALM1/SDHD/PSMC1/PPIF/PSMD9/TXN2/NDUFS4/COX4I1/PSMA7/SDHC/PSMD12	7.08217241539982
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/658	227/9376	2.69919526532143	NFKBIA/JUN/FOS/MT-ATP6/MT-CO1/MT-ND1/SOD2/MT-CYB/CYBA/MT-CO3/MT-ND2/NCF2/MT-ND5/GRB2/HMOX1/GSTO1/RAC1/NCF1/COX7A2L/MT-CO2/NDUFB5/HIF1A/NDUFB8/UQCRH/MT-ND4/MT-ATP8/NDUFA12/VEGFA/SLC25A6/MGST1/SDHB/VDAC2/UQCRFS1/COX6B1/AKR1A1/COX5A/NDUFV2/SDHD/CBR1/PPIF/NDUFS4/COX4I1/SDHC	7.11966495709588
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/658	56/9376	4.83456361267911	NFKBIA/TNF/CD14/CXCL8/CASP1/PYCARD/HSPA1A/CXCL2/CYCS/ITGB2/ARF1/IL1B/TLR4/HSPA6/HSPA8/CXCL3/NLRC4/NFKB2/IL18	7.90664348749493
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/658	138/9376	3.20091625919563	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/MT-CO3/MT-ND2/MT-ND5/ATP6V1F/PPA1/ATP6V0D1/COX7A2L/MT-CO2/NDUFB5/ATP6V1G1/NDUFB8/CYCS/UQCRH/MT-ND4/MT-ATP8/NDUFA12/ATP6V0E1/SDHB/UQCRFS1/COX6B1/COX5A/NDUFV2/SDHD/NDUFS4/ATP6V1D/COX4I1/SDHC	7.15557001769596
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/658	308/9376	2.31318833142541	MT-ATP6/MT-CO1/MT-ND1/SOD2/MT-CYB/MT-CO3/MT-ND2/MT-ND5/GPX1/TUBA1A/COX7A2L/MT-CO2/NDUFB5/PSMB3/PSMA5/NDUFB8/CLTA/CYCS/PSMD8/UQCRH/CLTB/BAX/MT-ND4/AP2S1/MT-ATP8/NDUFA12/PSMA2/POLR2E/SLC25A6/SDHB/VDAC2/UQCRFS1/COX6B1/DCTN3/PSMD4/COX5A/NDUFV2/SDHD/PSMC1/PPIF/PSMD9/NDUFS4/BECN1/COX4I1/PSMA7/ULK1/GPX3/POLR2A/SDHC/PSMD12	6.43778947106639
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	22/658	82/9376	3.82296686188746	HLA-A/HLA-C/HLA-B/PSME2/B2M/TNF/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/TAP1/HSPA1A/IFI30/HLA-DMA/HLA-DPA1/TAPBP/CTSB/HLA-DRA/HSPA6/TAP2/PSME1/HSPA8	7.05344890848682
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/658	142/9376	3.01040284258744	NFKBIA/FOSB/JUN/FOS/JUND/TNF/CYBA/SOCS3/JUNB/FCGR1A/NCF2/STAT1/IFNGR2/GRB2/SPI1/RAC1/NCF1/SYK/NCF4/TYROBP/STAT2/OSCAR/LILRB4/LILRA5/IL1B/FCGR3A/BTK/NFKB2/ACP5/IRF9	6.63166346971766
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/658	78/9376	3.83633387888707	NFKBIA/JUN/FOS/TNF/CYBA/FCGR1A/NCF2/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/HLA-DMA/NCF1/HLA-DPA1/NCF4/HLA-DRA/ITGB2/IL1B/TLR4/FCGR3A/MARCKSL1	6.91034985985387
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	36/658	196/9376	2.6172073692699	NFKBIA/JUN/HLA-A/FOS/HLA-C/HLA-B/HLA-F/UBC/HLA-E/STAT1/CXCL8/RAC1/CLEC2B/CDKN1A/BID/SYK/ATG3/CALM3/CXCL2/IRF7/HIF1A/STAT3/CYCS/STAT2/MAP1LC3B/BAX/ICAM1/VEGFA/CALM1/GNG5/CXCL3/BECN1/IRF9/IKBKE/BAK1/FAS	6.28582895836558
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/658	181/9376	2.67665284051789	TNF/CTSD/FCGR1A/HLA-DPB1/CD14/STAT1/IFNGR2/CLEC4E/HLA-DQA2/CORO1A/PLK3/HLA-DMA/ATP6V0D1/BID/SYK/CALM3/RHOA/CEBPB/RAB7A/HLA-DPA1/RAB5C/CYCS/HLA-DRA/BAX/ITGB2/IL1B/LAMP1/TLR4/FCGR3A/CALM1/RIPK2/CASP10/IL18/SPHK1	6.25744040804785
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	36/658	205/9376	2.50230558232634	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/CYBA/MT-CO3/MT-ND2/CTSD/NCF2/MT-ND5/RAC1/NCF1/COX7A2L/MT-CO2/GAPDH/NDUFB5/NCF4/PDK4/NDUFB8/UQCRH/MT-ND4/MT-ATP8/NDUFA12/SLC25A6/SDHB/VDAC2/UQCRFS1/COX6B1/COX5A/NDUFV2/SDHD/PPIF/MPC1/NDUFS4/COX4I1/SDHC	5.97471257408656
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	15/658	46/9376	4.64649134399366	PSMB9/PSME2/PSMB8/PSMB3/PSMA5/PSMD8/POMP/PSMA2/PSMB10/PSMD4/PSME1/PSMC1/PSMD9/PSMA7/PSMD12	6.81088321552212
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	64/658	480/9376	1.89989868287741	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/TNF/MT-CO3/UBE2L6/MT-ND2/UBC/MT-ND5/RAC1/GPX1/CSNK2B/BID/TUBA1A/CALM3/COX7A2L/MT-CO2/NDUFB5/PSMB3/RAB8A/PSMA5/NDUFB8/CYCS/PSMD8/UQCRH/MAP1LC3B/BAX/MT-ND4/MT-ATP8/CHMP2B/NDUFA12/PSMA2/IL1B/SLC25A6/SDHB/VDAC2/UQCRFS1/COX6B1/DCTN3/PSMD4/PARK7/COX5A/NDUFV2/CALM1/SDHD/PSMC1/PPIF/PRNP/PSMD9/NDUFS4/BECN1/COX4I1/FRAT1/CCS/DERL1/SMCR8/PSMA7/ULK1/GPX3/SDHC/BAK1/PSMD12/FAS	5.56041236463242
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/658	70/9376	3.66409031697785	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/RAC1/HLA-DMA/BID/HLA-DPA1/CYCS/HLA-DRA/ICAM1/ITGB2/ACTG1/CD40/EIF4G3	6.1461986460468
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/658	227/9376	2.32256336783471	NFKBIA/CCL3L3/HLA-A/CCL3/HLA-C/CCL4L2/HLA-B/CCL4/B2M/TNF/HLA-F/CXCR4/HLA-E/CXCL8/GRB2/GNAI2/RAC1/TAP1/CDKN1A/BID/CALM3/RHOA/EIF4EBP1/TAPBP/STAT3/CYCS/BAX/VEGFA/IL1B/TAP2/PTGER4/CALM1/PTGER2/GNG5/CCL5/BAK1/FAS	5.5415691508123
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/658	157/9376	2.63202524538749	JUN/FOS/MT-CO1/MT-CYB/TNF/MT-CO3/SOCS3/CXCL8/RAC1/BID/COX7A2L/MT-CO2/NDUFB5/NDUFB8/CYCS/UQCRH/BAX/NDUFA12/IL1B/SDHB/UQCRFS1/COX6B1/COX5A/NDUFV2/SDHD/NDUFS4/COX4I1/SDHC/FAS	5.66532649971552
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/658	78/9376	3.47096874756449	JUN/FOS/IRF1/TNF/CD14/CXCL8/CASP1/GNAI2/NLRP3/PYCARD/CFL1/CALM3/RHOA/ITGB2/SERPING1/IL1B/TLR4/IRF8/CALM1	6.02018636294526
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/658	39/9376	4.74974670719352	HLA-A/HLA-C/HLA-B/TNF/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/CD40/FAS	6.4464513458023
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/658	109/9376	3.00672039262709	NFKBIA/CCL3L3/JUN/FOS/CCL3/CCL4L2/CCL4/TNF/CD14/STAT1/CXCL8/RAC1/MAP3K8/IRF7/STAT2/IL1B/TLR4/CXCL10/TLR7/CCL5/CD40/IRF9/IKBKE	5.78922840333998
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	30/658	168/9376	2.54450716456795	TNFAIP3/FTL/TNF/FTH1/TNFSF10/STAT1/IFNGR2/CASP1/NLRP3/PYCARD/CHMP2A/BID/BIRC3/CHMP1B/STAT3/CHMP5/STAT2/BAX/CHMP2B/IL1B/TLR4/SLC25A6/STAT5A/VDAC2/CHMP4A/RBCK1/CHMP3/PPIA/IRF9/FAS	5.54947712335129
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/658	250/9376	2.22288145896657	CTSD/CD63/NPC2/BLOC1S1/ATP6V1F/LAMTOR4/ATP6V0D1/LITAF/CTSH/CTSZ/RAB7A/LAMTOR5/LIPA/LAMTOR2/LAMTOR1/CTSB/ATP6V1G1/CLTA/M6PR/LAPTM5/CLTB/AP2S1/CD68/VAMP8/LAMP1/ATP6V0E1/ARL8A/AP3S1/VPS29/CTSA/DTNBP1/VPS41/TLR7/AP5B1/BLOC1S2/ATP6V1D/ACP5/GM2A/KXD1	5.38399050315666
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/658	253/9376	2.196523180797	NFKBIA/JUN/TNF/UBC/CD14/ARPC3/CXCL8/CASP1/NLRP3/PYCARD/ARPC4/RAC1/CAPNS1/CALCOCO2/RHOA/CASP4/TLN1/CYCS/ARPC1B/MAP1LC3B/HCLS1/BAX/MYL12A/ARF1/FNBP1/HK1/IL1B/ACTG1/TLR4/PFN1/TNIP1/RBCK1/RIPK2/CUL1/NLRC4/CCL5/BECN1/ARPC2/IL18	5.30032735046965
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	22/658	105/9376	2.98555507309307	NFKBIA/GADD45B/TNFAIP3/CCL4L2/CCL4/BCL2A1/TNF/CD14/CXCL8/CSNK2B/SYK/BIRC3/CXCL2/TNFSF13B/ICAM1/IL1B/TLR4/BTK/UBE2I/CXCL3/NFKB2/CD40	5.62086881181505
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/658	105/9376	2.98555507309307	NFKBIA/JUN/IRF1/TNF/STAT1/CLEC4E/CASP1/NLRP3/PYCARD/PLK3/SYK/CALM3/RHOA/RRAS/STAT2/IL1B/CALM1/BCL3/NFKB2/CLEC4D/IRF9/IKBKE	5.62086881181505
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/658	44/9376	4.21000276319425	HLA-A/HLA-C/HLA-B/TNF/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/IL1B/FAS	5.8631976159735
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/658	45/9376	4.11644714623438	HLA-A/HLA-C/HLA-B/TNF/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/IL1B/FAS	5.75694500390559
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	51/658	388/9376	1.87296712938301	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/TNF/MT-CO3/MT-ND2/MT-ND5/CSNK2B/BID/TUBA1A/CALM3/COX7A2L/MT-CO2/GAPDH/NDUFB5/PSMB3/PSMA5/NDUFB8/CYCS/PSMD8/UQCRH/MT-ND4/MT-ATP8/NDUFA12/PSMA2/IL1B/SLC25A6/SDHB/ADAM17/VDAC2/UQCRFS1/COX6B1/PSMD4/COX5A/NDUFV2/CALM1/SDHD/PSENEN/PSMC1/PPIF/PSMD9/NDUFS4/BECN1/COX4I1/FRAT1/PSMA7/ULK1/SDHC/PSMD12/FAS	4.82472289236832
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/658	200/9376	2.27987841945289	NFKBIA/JUN/FOS/TNF/TNFSF10/ARPC3/CXCL8/CASP1/NLRP3/PYCARD/BRK1/ARPC4/RAC1/NCL/TUBA1A/RHOA/GAPDH/MYO1G/CASP4/CYCS/ARPC1B/HCLS1/BAX/ARF1/IL1B/ACTG1/TLR4/EZR/ARPC2/BAK1/IL18/FAS	5.02628562588778
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/658	83/9376	3.09019665287289	NFKBIA/CCL4L2/CCL4/CASP1/NLRP3/PYCARD/IRF7/POLR1D/IL1B/POLR2E/CXCL10/GSDMD/ADAR/POLR3GL/AIM2/CCL5/IKBKE/IL18	5.25458447366519
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/658	137/9376	2.49621724757615	NFKBIA/GADD45B/JUN/FOS/BCL2A1/TNF/CTSD/TNFSF10/MCL1/BID/BIRC3/TUBA1A/CTSH/CTSZ/CTSB/CYCS/BAX/PARP4/ACTG1/LMNB1/PMAIP1/CASP10/BAK1/FAS	4.84654901672146
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	36/658	250/9376	2.0518905775076	HLA-A/HLA-C/HLA-B/HLA-F/CXCR4/SMAP2/HLA-E/ARPC3/CHMP2A/ARPC4/HSPA1A/RHOA/CHMP1B/RAB7A/RAB8A/RAB5C/CHMP5/CLTA/ARPC1B/SNF8/CLTB/AP2S1/CHMP2B/SNX2/ARF1/CAPZB/HSPA6/RUFY1/SNX6/CHMP4A/VPS29/HSPA8/CHMP3/PML/LDLR/ARPC2	4.63116750862091
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/658	156/9376	2.37487335359676	NFKBIA/TNF/SOCS3/MX1/STAT1/GRB2/OAS1/OAS2/MX2/IFIT1/CDKN1A/BID/IRF7/STAT3/CYCS/STAT2/BAX/YWHAH/CXCL10/OAS3/RSAD2/LDLR/IRF9/IKBKE/BAK1/FAS	4.75718111663025
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/658	54/9376	3.43037262186198	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/CGA/CD40/FAS	4.92045594237703
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	21/658	119/9376	2.51457178616127	NFKBIA/JUN/FOS/TNFAIP3/IRF1/TNF/SOCS3/JUNB/MAP3K8/BIRC3/CXCL2/CEBPB/ICAM1/IL1B/ADAM17/CXCL10/CXCL3/BCL3/CCL5/CASP10/FAS	4.56791868101062
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/658	224/9376	2.03560573165436	NFKBIA/JUN/HLA-A/FOS/HLA-C/HLA-B/B2M/TNF/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/SPI1/HLA-DMA/CDKN1A/HLA-DPA1/TLN1/HLA-DRA/BAX/ICAM1/ITGB2/RAN/SLC25A6/STAT5A/VDAC2/TSPO/ANAPC16/POLB/NFKB2/CD40/IL15RA/ANAPC15	4.30973534476026
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/658	112/9376	2.54450716456795	NFKBIA/TNF/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/GNAI2/HSPA1A/HLA-DMA/BIRC3/HLA-DPA1/STAT3/CYCS/HLA-DRA/TLR4/HSPA6/HSPA8/PPIF/LDLR/CD40	4.51741321544594
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/658	105/9376	2.57843392676219	JUN/UBC/BNIP3L/GABARAP/CSNK2B/CALCOCO2/CITED2/RRAS/RAB7A/HIF1A/RAB5C/FKBP8/TAX1BP1/MAP1LC3B/GABARAPL1/TOMM20/BECN1/ULK1/CCZ1	4.46835756443031
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/658	142/9376	2.30797551265037	JUN/FOS/DUSP1/KLF2/TNF/CYBA/NCF2/HMOX1/GSTO1/RAC1/NCF1/CALM3/RHOA/ICAM1/VEGFA/IL1B/ACTG1/MGST1/SUMO3/SUMO2/TXN/CALM1/TXN2	4.31458474032247
Genetic Information Processing	Transcription	hsa03040	Spliceosome	33/658	243/9376	1.93508199181958	SF3B5/HNRNPA1/HSPA1A/SRSF5/SRSF3/LSM6/SRSF7/SYF2/HNRNPM/SRSF9/TXNL4A/SNRPD2/CCDC12/SF3B6/CWC15/HSPA6/ZMAT2/BUD31/SNRPF/PQBP1/SNRPB/LSM4/HSPA8/SLU7/HNRNPU/RBM17/RBMX2/ACIN1/SNRPC/DDX46/MAGOH/DHX8/BCAS2	4.05729189960293
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/658	214/9376	1.9975570263898	NFKBIA/JUN/HLA-A/FOS/HLA-C/HLA-B/B2M/TNF/HLA-F/BST2/CXCR4/HLA-E/GNAI2/APOBEC3A/RAC1/TAP1/CFL1/BID/CALM3/TAPBP/CYCS/BAX/APOBEC3G/TLR4/TAP2/CALM1/GNG5/CUL1/BAK1/FAS	4.05545538124096
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	32/658	235/9376	1.94032205910884	MT-ATP6/MT-CO1/MT-ND1/MT-CYB/MT-CO3/MT-ND2/MT-ND5/GRB2/COX7A2L/MT-CO2/COX14/NDUFB5/ACSL1/COA6/NDUFB8/UQCRH/MT-ND4/MT-ATP8/NDUFA12/ACTG1/SDHB/UQCRFS1/COX6B1/COA3/COX5A/CPT1A/NDUFV2/SDHD/NDUFS4/COX4I1/SLC25A20/SDHC	4.0105492483552
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/658	71/9376	2.80970931974828	NFKBIA/JUN/CXCL8/RAC1/ATP6V1F/ATP6V0D1/CXCL2/ATP6V1G1/ATP6V0E1/ADAM17/HBEGF/CXCL3/ATP6V1D/CCL5	4.20503835312584
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/658	42/9376	3.39267621942394	SAT1/FTL/FTH1/HMOX1/SAT2/ACSL1/GPX4/MAP1LC3B/VDAC2/PRNP	4.2693802113297
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/658	50/9376	3.13483282674772	TNF/CXCL8/HBA1/HBA2/ICAM1/ITGB2/IL1B/TLR4/GYPC/CD40/IL18	4.15806545409909
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/658	66/9376	2.80666850879617	JUN/TNF/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/HLA-DMA/HLA-DPA1/STAT3/HLA-DRA/IL1B/TLR4/IL18	4.04637151360082
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/658	110/9376	2.33169383807682	LDHA/IFNGR2/HMOX1/ENO1/CDKN1A/GAPDH/EIF4EBP1/TIMP1/PGK1/ALDOA/HIF1A/STAT3/PFKFB3/VEGFA/HK1/CDKN1B/TLR4/EIF4E2	3.85962168264249
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/658	193/9376	1.91958675213002	NFKBIA/CCL3L3/CCL3/CCL4L2/CCL4/CXCR4/STAT1/CXCL8/GRB2/GNAI2/RAC1/FGR/NCF1/RAP1B/RHOA/CXCL2/RAP1A/STAT3/STAT2/CXCL16/CCR2/CXCL10/PPBP/GNG5/CXCL3/CCL5	3.54624895693622
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/658	205/9376	1.87672918674476	NFKBIA/JUN/HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/GRB2/RAC1/PKM/CDKN1A/ATP6V0D1/SYK/RHOA/IRF7/STAT3/SP100/BAX/CDKN1B/STAT5A/YWHAH/PSMC1/POLB/NFKB2/PMAIP1/IRF9/BAK1	3.48677722943766
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/658	116/9376	2.21108898438319	CYBA/CXCR4/NCF2/GNAI2/RAC1/VASP/MSN/NCF1/RAP1B/RHOA/RAP1A/NCF4/ICAM1/ITGB2/MYL12A/ACTG1/EZR/SIPA1	3.60570097976901
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/658	138/9376	2.06510726399718	NFKBIA/JUN/FOS/TNF/ARPC3/CXCL8/CASP1/NLRP3/PYCARD/ARPC4/RAC1/RHOG/RHOA/ARPC1B/IL1B/ACTG1/TLR4/NLRC4/ARPC2/IL18	3.46285306042213
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/658	94/9376	2.27381491301817	NFKBIA/FOSB/JUN/FOS/TNFAIP3/JUND/TNF/CXCL8/S100A9/CXCL2/CEBPB/IL1B/CXCL10/CXCL3/IKBKE	3.40988416771854
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/658	67/9376	2.55210270834278	LDHA/ALDH2/FBP1/ENO1/PKM/GAPDH/PGK1/ALDOA/TPI1/HK1/AKR1A1/ALDH3B1	3.50264800553159
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/658	87/9376	2.29298116898997	GADD45B/JUN/FOS/GRB2/RAC1/CDKN1A/RHOA/CYCS/BAX/EREG/RALB/PMAIP1/AREG/BAK1	3.32856848834837
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/658	37/9376	3.08091678304444	TNF/HBA1/HBA2/ICAM1/IL1B/APOL1/IL18/FAS	3.48413953750096
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/658	169/9376	1.85493066671463	CTSD/UBC/GABARAP/DDIT4/CALCOCO2/ATG3/RRAS/RAB7A/RAB8A/HIF1A/CTSB/TAX1BP1/MAP1LC3B/VAMP8/IGBP1/GABARAPL1/LAMP1/VPS41/BECN1/SMCR8/ULK1/WDR45	3.08109670175446
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/658	100/9376	2.13738601823708	CCL3L3/CCL3/CCL4L2/CCL4/TNF/CXCR4/TNFSF10/CXCL8/CXCL2/CCR2/CXCL10/PPBP/CXCL3/CCL5/IL18	3.14135969966813
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/658	72/9376	2.37487335359676	NFKBIA/ISG15/TNF/CXCL8/IRF7/IFIH1/CXCL10/ADAR/ZNFX1/PIN1/CASP10/IKBKE	3.2172458179037
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/658	133/9376	1.92846858788308	HLA-A/HLA-C/HLA-B/TNF/HLA-E/CD48/TNFSF10/IFNGR2/GRB2/RAC1/BID/SYK/TYROBP/ICAM1/ICAM2/ITGB2/FCGR3A/FAS	2.96262519464359
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/658	75/9376	2.27987841945289	GSTO1/CDKN1A/BID/BIRC3/CYCS/BAX/MGST1/ERCC1/PMAIP1/SLC31A1/BAK1/FAS	3.05720582568626
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/658	32/9376	3.11702127659574	BID/BIRC3/CYCS/BAX/PMAIP1/BECN1/BAK1	3.29551998559565
Human Diseases	Immune disease	hsa05310	Asthma	7/658	32/9376	3.11702127659574	TNF/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/CD40	3.29551998559565
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/658	50/9376	2.5648632218845	CXCR4/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/TNFSF13B/HLA-DRA/CD40/IL15RA	3.0479218896127
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/658	87/9376	2.1291967997764	MT-CO1/MT-CYB/MT-CO3/COX7A2L/MT-CO2/TPM3/UQCRH/ATP1B3/UQCRFS1/COX6B1/COX5A/COX4I1/CACNA2D4	2.90693242486713
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/658	78/9376	2.19219078793547	ARPC3/ARPC4/RAC1/RHOG/RHOA/CLTA/ARPC1B/CLTB/HCLS1/ACTG1/ARPC2/MAD2L2	2.90461412376514
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/658	98/9376	2.03560573165436	FCGR1A/ARPC3/ARPC4/RAC1/VASP/CFL1/NCF1/SYK/ARPC1B/MARCKS/FCGR3A/MARCKSL1/ARPC2/SPHK1	2.83119936245595
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/658	51/9376	2.51457178616127	ATP6V1F/ATP6V0D1/ATP6V1G1/ARF1/ATP6V0E1/ACTG1/SEC61B/ATP6V1D/KCNQ1	2.97948142941245
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/658	109/9376	1.96090460388723	NFKBIA/JUN/FOS/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/HLA-DMA/HLA-DPA1/HIF1A/STAT3/HLA-DRA/IL1B/STAT5A/NFKBIE	2.77213320109907
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/658	163/9376	1.74837302105283	NFKBIA/JUN/FOS/TNF/STAT1/CXCL8/GRB2/CDKN1A/BID/IRF7/STAT3/CYCS/STAT2/IFIH1/BAX/TLR4/STAT5A/CASP10/IKBKE/FAS	2.64789977083691
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/658	174/9376	1.71973587674248	PPP1R15A/UBXN1/ERP29/DNAJA1/HSPA1A/BAX/OS9/SEC61B/HSPA6/DNAJA2/LMAN2/BAG1/FBXO6/HSPA8/DNAJB1/CUL1/DERL1/DNAJC1/DNAJB12/SEC13/BAK1	2.63267236009049
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/658	73/9376	2.14714577174501	BST2/CXCR4/MX1/APOBEC3A/MX2/APOBEC3G/RAN/CHMP4A/PPIA/PIN1/MDFIC	2.70307864148971
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/658	103/9376	1.93678991943813	NFKBIA/CCL3L3/JUN/FOS/CCL3/TNF/IFNGR2/CXCL8/GNAI2/GNA15/IL1B/TLR4/CCL5/FAS	2.62627889634118
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/658	93/9376	1.99182926430696	NFKBIA/JUN/FOS/HLA-DPB1/STAT1/IFNGR2/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/STAT5A/NOTCH1/NFKBIE	2.6407322535177
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/658	116/9376	1.84257415365266	FBP1/ENO1/PKM/GAPDH/PGK1/ALDOA/TPI1/HK1/SDHB/TALDO1/MDH2/TKT/SDHD/SDHC/PRPS2	2.50854436835682
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/658	68/9376	2.09547648846773	BCL2A1/FCGR1A/CD14/GRB2/SPI1/EIF4EBP1/STAT3/PIM1/STAT5A/PML	2.49068888526933
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/658	59/9376	2.17361289990212	LAP3/GSTO1/GPX1/GPX4/GSTK1/PRDX6/MGST1/ODC1/GPX3	2.48429396988501
Genetic Information Processing	Translation	hsa03010	Ribosome	24/658	222/9376	1.54045839152222	RPS26/RPS9/RPL36A/RPS10/RPL3/RPS20/RPL36AL/RPS4X/RPS3A/MRPL41/RPS2/RPL29/MRPL54/RPL19/RPL9/MRPS15/RPL7/RPL27A/RPL24/DAP3/MRPL18/RPL10A/RPL13/RPS16	2.23884202413341
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/658	133/9376	1.71419430034052	GADD45B/KLF2/SOD2/TNFSF10/GRB2/SGK1/GABARAP/PLK3/CDKN1A/STAT3/BCL6/CDKN2D/CDKN1B/GABARAPL1/HOMER3/S1PR4	2.27890319141966
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/658	101/9376	1.83406060970839	JUN/TNF/STAT1/CXCL8/RAC1/STAT3/BAX/ICAM1/VEGFA/PIM1/CDKN1B/IL1B/STAT5A	2.31521587472747
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/658	33/9376	2.59077093119646	VAMP5/STX11/VAMP8/STX6/STX4/STX8	2.51484715194833
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/658	333/9376	1.41208685889537	HLA-A/HLA-C/ISG15/HLA-B/IRF1/TNF/HLA-F/HLA-E/MX1/STAT1/GRB2/MX2/ATP6V1F/PKM/CDKN1A/ATP6V0D1/EIF4EBP1/ATP6V1G1/STAT2/BAX/OASL/VEGFA/CDKN1B/ATP6V0E1/PTGER4/NOTCH1/PSMC1/PPP2R3C/ATP6V1D/IRF9/IKBKE/BAK1/FAS	2.10351091290922
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/658	103/9376	1.79844778233541	TNF/CD14/CXCL8/CXCL2/RAB7A/RAB5C/ITGB2/GNA15/IL1B/TLR4/SERPINB6/SERPINB9/CXCL3	2.23843843434567
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/658	28/9376	2.54450716456795	ATP6V1F/ATP6V0D1/ATP6V1G1/ATP6V0E1/ATP6V1D	2.24853547450495
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/658	99/9376	1.72718062079764	FCGR1A/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/ICAM1/PTAFR/ITGB2/KRT19/FCGR3A/C3AR1	1.99823365010035
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/658	157/9376	1.54291135074439	SGK1/CASP1/RAC1/DUSP2/CEBPB/RAB7A/LIPA/HIF1A/RAB5C/ADAM17/UQCRFS1/PTGER4/CPT1A/PTGER2/ODC1/VPS41/SPHK1	1.88463387503437
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/658	79/9376	1.80370128121273	ATP6V1F/ATP6V0D1/ATP6V1G1/CLTA/CLTB/AP2S1/NAPA/ATP6V0E1/ATP6V1D/NSF	1.97072916358474
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/658	90/9376	1.74157379263762	NFKBIA/JUN/FOS/STAT1/IFNGR2/CSNK2B/HIF1A/STAT3/TLR4/NFKBIE/BATF	1.94200990692058
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/658	170/9376	1.50874307169676	JUN/ARPC3/ARPC4/RAC1/VASP/MSN/TUBA1A/RHOA/RAP1A/RAB8A/ARPC1B/MYL6/HCLS1/MYL12A/ACTG1/EZR/YBX3/ARPC2	1.83898266712532
Organismal Systems	Immune system	hsa04611	Platelet activation	14/658	126/9376	1.58324890239784	GNAI2/VASP/SYK/APBB1IP/RAP1B/RHOA/RAP1A/FERMT3/TLN1/MYL12A/VAMP8/ACTG1/BTK/ORAI1	1.81074997982297
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/658	61/9376	1.86875280283024	FTL/FTH1/HMOX1/MT2A/ATP1B3/SLC31A1/MT1X/MT1E	1.87007859505166
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/658	31/9376	2.2982645357388	FBP1/ALDOA/TALDO1/TKT/PRPS2	1.98904468775871
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/658	31/9376	2.2982645357388	SEC61B/SRP54/SEC11C/SRP19/TMEM208	1.98904468775871
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/658	32/9376	2.22644376899696	GABARAP/ATG3/IGBP1/GABARAPL1/BECN1	1.90917776624242
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/658	201/9376	1.41783483796821	GADD45B/BCL2A1/NFKBIZ/FCGR1A/CD14/CXCL8/SPI1/CDKN1A/BIRC3/ID2/CEBPB/LYL1/BAX/BCL6/CDKN1B/MAX/TAF15/PML/CD40/BAK1	1.64509049232029
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/658	85/9376	1.67638119077418	TYMP/UPP1/APRT/CDA/GUK1/NUDT16/CMPK2/ITPA/HPRT1/DGUOK	1.72091693138168
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	28/658	300/9376	1.32992907801418	GADD45B/JUN/FOS/DUSP1/JUND/TNF/NR4A1/CD14/GRB2/RAC1/MAP3K8/HSPA1A/DUSP2/RAP1B/RRAS/RAP1A/EREG/VEGFA/IL1B/HSPA6/HSPA8/MAX/NFKB2/AREG/DUSP3/DUSP10/CACNA2D4/FAS	1.59560037541953
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/658	120/9376	1.54366767983789	NFKBIA/JUN/GRB2/RAC1/ARHGDIB/CALM3/RAP1B/RHOA/RAP1A/BAX/CALM1/RIPK2/NFKBIE	1.64665500446033
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/658	86/9376	1.6568883862303	JUN/GRB2/CDKN1A/EIF4EBP1/EREG/CDKN1B/STAT5A/NRG1/HBEGF/AREG	1.68121441442713
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/658	75/9376	1.70990881458967	ENO1/PKM/GAPDH/PGK1/ALDOA/TPI1/TALDO1/TKT/PRPS2	1.69573713462355
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/658	144/9376	1.48429584599797	PSMB3/PSMA5/CYCS/PSMD8/PSMA2/SLC25A6/VDAC2/PSMD4/PSMC1/PPIF/PSMD9/BECN1/PSMA7/ULK1/PSMD12	1.60891923850456
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/658	44/9376	1.94307819839735	POLE4/PARP4/POLB/POLD4/MPG/APEX1	1.72256980832552
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	16/658	158/9376	1.44296102497018	TNF/GRB2/SGK1/DDIT4/ATP6V1F/LAMTOR4/RHOA/LAMTOR5/EIF4EBP1/LAMTOR2/LAMTOR1/ATP6V1G1/EIF4E2/ATP6V1D/SEC13/ULK1	1.54264451619028
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/658	77/9376	1.6654955986263	GADD45B/STAT1/RAC1/CDKN1A/STAT3/BAX/VEGFA/RALB/BAK1	1.61087773517281
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/658	195/9376	1.3883874990258	CYBA/FCGR1A/NCF2/CASP1/RAC1/NCF1/SYK/NCF4/CASP4/AQP9/ITGB2/ACTG1/TLR4/FCGR3A/SLC25A6/VDAC2/GSDMD/PPIF/TLR7	1.5056627549213
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/658	100/9376	1.56741641337386	TNF/FCGR1A/HLA-DPB1/CD14/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/IL1B/CD37/CD38	1.56715400516848
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/658	35/9376	2.03560573165436	FBP1/ALDOA/TPI1/PFKFB3/HK1	1.68624988947138
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/658	160/9376	1.42492401215805	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/HLA-DRA/ICAM1/ICAM2/ITGB2/VCAN/SIGLEC1/CD40	1.48932741671131
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/658	298/9376	1.29103853450562	CCL3L3/CCL3/CCL4L2/CCL4/TNF/CXCR4/TNFSF10/IFNGR2/CXCL8/CSH1/CXCL2/TNFSF13B/IL1B/CXCL16/CCR2/CXCL10/IL1RN/TNFSF12/PPBP/OSM/CXCL3/CCL5/INHBA/CD40/IL15RA/IL18/FAS	1.40266412793204
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/658	91/9376	1.56585056281105	NFKBIA/JUN/FOS/GRB2/RAC1/SYK/LILRB4/LILRA5/BTK/NFKBIE	1.49012138354628
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/658	36/9376	1.9790611279973	POLE4/RNASEH2C/RNASEH2B/SSBP1/POLD4	1.6168799398215
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/658	115/9376	1.48687723007797	FOS/JUND/NACA/NR4A2/SGK1/GNAI2/CDKN1A/MAFB/RHOA/HBEGF/PDE4B/OXSR1	1.44321021785849
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/658	47/9376	1.81905193041454	LDHA/ALDH2/PKM/MDH2/AKR1A1/GRHPR	1.5464396395427
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/658	37/9376	1.92557298940278	GADD45B/CDKN1A/TPM3/BAX/BAK1	1.54971379610056
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/658	70/9376	1.62848458532349	JUN/GRB2/RAC1/CDKN1A/RAP1B/RAP1A/HIF1A/VEGFA	1.44994750469214
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/658	71/9376	1.6055481827133	FOS/IRF1/SOCS3/STAT1/GRB2/STAT3/STAT5A/CGA	1.40705101376683
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/658	38/9376	1.87490001599744	TAP1/BTK/TAP2/ORAI1/CD40	1.48461362051657
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/658	204/9376	1.32713510936289	TNF/CD63/GRB2/RAC1/MSN/CDKN1A/RHOA/RRAS/PLAUR/HIF1A/STAT3/HCLS1/VEGFA/ACTG1/TLR4/HPSE/EZR/HBEGF/FAS	1.29777788758579
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/658	157/9376	1.36139236830387	GADD45B/HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/CXCL8/CDKN1A/CALM3/RRAS/EIF4EBP1/SLC25A6/VDAC2/CALM1/NBN	1.25451843758751
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/658	30/9376	1.89989868287741	SDHB/MDH2/SDHD/SDHC	1.3562242572652
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/658	41/9376	1.73771220994885	TYMP/CXCL8/CDKN1A/VEGFA/HBEGF	1.300504596347
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/658	76/9376	1.49992001279795	GADD45B/GRB2/CDKN1A/CALM3/BAX/CAMK1/CALM1/BAK1	1.20214262742122
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	20/658	226/9376	1.26099470102483	NFKBIA/JUN/FOS/GNAI2/RAC1/FFAR2/CALM3/RAP1B/RHOA/RRAS/RAP1A/HCAR3/ATP1B3/ORAI1/CALM1/PTGER2/CRH/PDE4B/CGA/HCAR2	1.0911024103002
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/658	77/9376	1.48044053211226	NFKBIA/GADD45B/GRB2/CDKN1A/BAX/CDKN1B/STAT5A/BAK1	1.16293925587451
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/658	139/9376	1.33266274518379	JUN/FOS/CTSD/GRB2/GNAI2/FKBP5/HSPA1A/CALM3/KRT19/HSPA6/CALM1/HSPA8/HBEGF	1.08551604726343
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/658	43/9376	1.6568883862303	ALDH2/ACSL1/ACAA2/ACAA1/CPT1A	1.1860563722394
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/658	44/9376	1.61923183199779	ARHGDIB/RAB5C/DYNLL1/STX4/NSF	1.13105155009009
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/658	142/9376	1.30450789845456	UBE2L6/SOCS3/UBC/BIRC3/UBE2E1/UBE2I/ANAPC16/UBE2Z/PML/CUL1/UBE2M/UBE2Q1/ANAPC15	1.00447226975792
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/658	168/9376	1.27225358228398	SOCS3/STAT1/IFNGR2/GRB2/MCL1/CSH1/CDKN1A/STAT3/STAT2/PIM1/STAT5A/PTPN2/OSM/IRF9/IL15RA	0.978218205325065
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/658	93/9376	1.37895872144328	NFKBIA/GADD45B/CDKN1A/BIRC3/CYCS/BAX/CDKN1B/MAX/BAK1	1.00897256663057
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/658	69/9376	1.44557508479803	GNAI2/CALM3/CTSB/PTGER4/ORAI1/CALM1/PTGER2	1.02054166364062
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/658	144/9376	1.28638973319824	NFKBIA/TNF/CD14/CXCL8/ALDH2/CXCL2/IL1B/TLR4/CPT1A/CXCL3/C3AR1/IKBKE/FAS	0.951438991807437
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/658	34/9376	1.67638119077418	POLR1D/POLR2E/POLR3GL/POLR2A	1.08542845264055
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/658	34/9376	1.67638119077418	BHLHE40/NFIL3/CUL1/PER1	1.08542845264055
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/658	82/9376	1.39016976795908	TYMP/UPP1/GSTO1/CDA/MGST1/CES1/ITPA/HPRT1	0.974875958017966
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/658	70/9376	1.42492401215805	NFKBIA/TNF/SOCS3/ACSL1/STAT3/CPT1A/NFKBIE	0.980322390556671
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/658	46/9376	1.54883044799789	FTL/BLVRA/FTH1/HMOX1/BLVRB	1.02510049628759
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/658	108/9376	1.31937408533153	NUP214/SAP18/RAN/SUMO3/UBE2I/SUMO2/NUP62/ACIN1/MAGOH/SEC13	0.917083102519534
NA	NA	hsa03272	Virion - Hepatitis viruses	5/658	48/9376	1.48429584599797	CD63/CHMP1B/LAMP1/CHMP4A/LDLR	0.924117610730156
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/658	73/9376	1.36636549111046	GADD45B/GRB2/CDKN1A/STAT3/BAX/STAT5A/BAK1	0.863285868624294
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/658	125/9376	1.25393313069909	TNF/CTSD/GNAI2/RAC1/BID/RHOA/BAX/S1PR4/PPP2R3C/SPTSSA/SPHK1	0.785181730131836
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/658	50/9376	1.42492401215805	SAT1/LAP3/ALDH2/SAT2/ODC1	0.827634760639917
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/658	75/9376	1.32992907801418	GADD45B/CDKN1A/BID/CYCS/BAX/PMAIP1/FAS	0.788091340581738
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/658	232/9376	1.16696363064668	TMSB4X/CXCR4/ARPC3/BRK1/ARPC4/RAC1/CFL1/MSN/RHOA/RRAS/ARPC1B/ITGB2/MYL12A/ACTG1/EZR/PFN1/SPATA13/RGCC/ARPC2	0.70743723791308
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/658	76/9376	1.31243001119821	GNAI2/CALM3/ATP1B3/ACTG1/EZR/CALM1/KCNQ1	0.751291056433165
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/658	52/9376	1.37011924245967	NPC2/LIPA/VDAC2/TSPO/LDLR	0.735245468740136
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/658	143/9376	1.19574042978298	TNF/FCGR1A/HLA-DPB1/HLA-DQA2/HLA-DMA/HLA-DPA1/SSB/HLA-DRA/FCGR3A/SNRPB/TRIM21/CD40	0.647988489193784
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/658	212/9376	1.14262774559844	GNAI2/RAC1/VASP/APBB1IP/CALM3/RAP1B/RHOA/RRAS/RAP1A/TLN1/ITGB2/VEGFA/RALB/ACTG1/PFN1/CALM1/SIPA1	0.577058125402317
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/658	93/9376	1.22574108572736	RAC1/CSNK2B/RAP1B/RHOA/RAP1A/MYL12A/ACTG1/SNAI1	0.601032644908781
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/658	80/9376	1.2468085106383	GRB2/EIF4EBP1/STAT3/BAX/VEGFA/EIF4E2/NRG1	0.609041967726354
NA	NA	hsa04517	IgSF CAM signaling	23/658	299/9376	1.09609539396773	CD48/ARPC3/GRB2/ARPC4/RAC1/MSN/TUBA1A/RAP1B/RHOA/RAP1A/ARPC1B/MYL6/ICAM1/ICAM2/ITGB2/MYL12A/DYNLL1/ACTG1/EZR/SLAMF7/DOK1/CRTAM/ARPC2	0.463935013992242
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/658	18/9376	1.58324890239784	TCN2/ZNF143	0.680438400426004
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/658	44/9376	1.29538546559823	TAF15/TAF7/TAF12/GTF2F1	0.539533291854667
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/658	71/9376	1.20416113703498	LDHA/SCO2/PKM/SLC16A3/HIF1A/HK1	0.474388567313821
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/658	98/9376	1.16320327523107	NR4A2/NR4A1/CALM3/ATP1B3/CAMK1/ORAI1/CALM1/LDLR	0.446174634478683
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/658	99/9376	1.15145374719843	JUN/FOS/GRB2/CDKN1A/BAX/CDKN1B/NOTCH1/HBEGF	0.416182672406376
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/658	154/9376	1.1103303990842	JUN/FOS/GNAI2/CDKN1A/CALM3/RHOA/MYL6/ACTG1/CAMK1/CALM1/CD38/CACNA2D4	0.379256596439815
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/658	59/9376	1.20756272216784	GADD45B/GRB2/CDKN1A/BAX/BAK1	0.439367034136635
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/658	20/9376	1.42492401215805	NANS/CYB5R3	0.522602300771276
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/658	47/9376	1.21270128694303	TNF/SOCS3/PKM/HK1	0.401598102996917
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/658	102/9376	1.11758746051612	RAC1/RAP1B/RHOA/RAP1A/RAB8A/ATP1B3/CD38/KCNQ1	0.32803312704224
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/658	75/9376	1.13993920972644	GPX1/ASGR1/ASGR2/ATP1B3/CGA/GPX3	0.334268443560833
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/658	21/9376	1.35707048776958	ALDH2/PPCS	0.450020047248469
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/658	62/9376	1.1491322678694	DTX3L/ADAM17/TLE3/NOTCH1/PSENEN	0.323660352574796
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/658	76/9376	1.12494000959846	PLIN2/UBC/ACSL1/OLR1/ACAA1/CPT1A	0.300439485445111
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/658	63/9376	1.13089207314131	POLE4/POLR2E/ERCC1/POLD4/POLR2A	0.2863709579394
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/658	63/9376	1.13089207314131	GADD45B/CDKN1A/BAX/PTCH2/BAK1	0.2863709579394
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/658	22/9376	1.29538546559823	ALDH2/ALDH3B1	0.381058744645449
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/658	149/9376	1.05195732441199	MT-ND1/MT-ND2/MT-ND5/GNAI2/NDUFB5/NDUFB8/MT-ND4/NDUFA12/NDUFV2/GNG5/NDUFS4	0.175630446396417
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/658	37/9376	1.15534379364167	HK1/NANS/GALK1	0.260096635166962
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/658	23/9376	1.23906435839831	SSBP1/POLD4	0.315350436445757
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/658	122/9376	1.05117345159201	FBP1/EIF4EBP1/RAB8A/PFKFB3/RAB2A/CPT1A/PPP2R3C/TBC1D1/ULK1	0.156296780075069
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/658	122/9376	1.05117345159201	NFKBIA/JUN/FOS/TNF/GRB2/MAP3K8/RHOA/PPP2R3C/NFKBIE	0.156296780075069
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/658	122/9376	1.05117345159201	FOS/SOCS3/JUNB/STAT1/GRB2/GNAI2/CSH1/STAT3/STAT5A	0.156296780075069
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/658	38/9376	1.12494000959846	NADK/CD38/SIRT2	0.21201010013228
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/658	110/9376	1.03630837247859	TNF/EMP3/ID2/RHOA/SKIL/CUL1/INHBA/TGIF1	0.105231831576384
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/658	53/9376	1.07541434879853	CLTA/CLTB/ATP1B3/AP2S1	0.15125308124739
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/658	69/9376	1.03255363199859	TNF/GRB2/RAC1/SYK/BTK	0.0745605822471992
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/658	69/9376	1.03255363199859	FOSB/JUN/FOS/CALM3/CALM1	0.0745605822471992
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/658	41/9376	1.04262732596931	SSBP1/POLD4/NBN	0.0751472357451037
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/658	217/9376	0.984970515316628	JUN/FOS/KLF4/GRB2/GNAI2/GSTO1/EIF4EBP1/STAT3/VEGFA/BCL6/STAT5A/MGST1/PTGES3/AIP/IKBKE	-0.0615375327979095
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/658	57/9376	0.999946675198635	ACSL1/ACAA2/ACAA1/CPT1A	-0.000110935915313663
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/658	12/9376	1.18743667679838	ASGR1	0.178486202247444
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/658	28/9376	1.01780286582718	GCH1/CBR1	0.0259178955453199
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/658	148/9376	0.962786494701388	GADD45B/JUN/FOS/GRB2/CDKN1A/BAX/NOTCH1/NFKB2/FRAT1/BAK1	-0.12536254419772
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/658	59/9376	0.966050177734274	TYMP/UPP1/CDA/CMPK2	-0.0718646998004575
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/658	13/9376	1.09609539396773	XRCC5	0.0952482244792792
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/658	29/9376	0.982706215281417	CALM3/CALM1	-0.0256237730212753
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/658	107/9376	0.932193278981905	LDHA/FBP1/PKM/CALM3/PPP4C/CPT1A/CALM1	-0.19379311510847
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/658	30/9376	0.949949341438703	TNF/IL1B	-0.0754306218294313
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/658	138/9376	0.929298268798731	SOCS3/GRB2/FBP1/CALM3/EIF4EBP1/HK1/EIF4E2/FLOT1/CALM1	-0.229863896851711
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/658	62/9376	0.919305814295519	SOD2/HSPA1A/HSPA6/HSPA8	-0.175129829170978
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/658	93/9376	0.919305814295519	JUN/GRB2/CALM3/CALM1/HBEGF/CGA	-0.214847198534788
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/658	93/9376	0.919305814295519	CST3/CALM3/ATP1B3/CALM1/CD38/LYZ	-0.214847198534788
NA	NA	hsa04518	Integrin signaling	10/658	154/9376	0.925275332570165	RAC1/LIMS1/FERMT3/TLN1/ICAM1/ICAM2/ITGB2/VEGFA/ACTG1/PARVB	-0.256863233295374
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/658	78/9376	0.913412828306445	ENO1/BTG1/LSM6/NUDT16/LSM4	-0.210958115414988
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/658	31/9376	0.919305814295519	ALDH2/AKR1A1	-0.123629920551727
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/658	31/9376	0.919305814295519	ALDH2/ALDH3B1	-0.123629920551727
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/658	31/9376	0.919305814295519	MDH2/GRHPR	-0.123629920551727
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/658	155/9376	0.919305814295519	NR4A1/GNAI2/CDKN1A/RAP1B/RAP1A/CDKN1B/ORAI1/CRH/AIP/LDLR	-0.27829745461018
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/658	140/9376	0.916022579244464	KLF2/GNAI2/CALM3/RRAS/MAP1LC3B/CALM1/GNG5/BECN1/SPHK1	-0.275026625486547
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/658	79/9376	0.901850640606364	GSTO1/GSTK1/MGST1/ALDH3B1/CBR1	-0.240668777648747
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/658	48/9376	0.890577507598784	ALDH2/ACAA2/ACAA1	-0.208796447612671
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/658	32/9376	0.890577507598784	HK1/GALK1	-0.170335562787428
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	13/658	203/9376	0.912512914189887	JUN/GRB2/RAC1/VASP/BIRC3/RAP1B/RHOA/RAP1A/TLN1/MYL12A/VEGFA/ACTG1/PARVB	-0.346199491237375
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/658	49/9376	0.872402456423299	FOSB/JUN/GNAI2	-0.246013827606156
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/658	97/9376	0.88139629618024	FOS/GNAI2/CALM3/CALM1/GNG5/PER1	-0.322569784489863
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/658	128/9376	0.890577507598784	APRT/GUK1/NUDT16/PDE4B/ITPA/HPRT1/DGUOK/PRPS2	-0.342434749745071
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/658	16/9376	0.890577507598784	ALDH3B1	-0.120342442679797
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/658	130/9376	0.876876315174188	NFKBIA/JUN/FOS/GRB2/GNAI2/VEGFA/GNA15/GNG5	-0.388352842960866
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/658	67/9376	0.850700902780928	CALM3/RAP1B/RAP1A/CALM1	-0.336924987174596
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/658	99/9376	0.863590310398821	JUN/FOS/GRB2/RAC1/EIF4EBP1/HIF1A	-0.374842816440609
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/658	17/9376	0.838190595387091	LAMP1	-0.183444058277573
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/658	52/9376	0.822071545475801	CYP19A1/CGA/LDLR	-0.353456602470779
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/658	194/9376	0.88139629618024	DYNLT1/TUBA1A/MYO1G/TPM3/DYNLRB1/MYL6/MYL12A/CAPZB/DYNLL1/ACTG1/DCTN3/TNNT1	-0.458585823504022
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/658	18/9376	0.791624451198919	ACSL1	-0.243098143058972
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/658	70/9376	0.814242292661746	GSTO1/GSTK1/MGST1/CBR1	-0.428552951849728
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/658	88/9376	0.809615915998895	PLAUR/SERPINA1/ITGB2/SERPING1/C3AR1	-0.492947903805585
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/658	19/9376	0.749960006398976	HPSE	-0.299714750631126
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/658	38/9376	0.749960006398976	HK1/GALK1	-0.424291660059864
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/658	38/9376	0.749960006398976	SGK1/ATP1B3	-0.424291660059864
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/658	89/9376	0.800519107953963	GNAI2/GABARAP/GABARAPL1/GNG5/NSF	-0.519455961590054
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/658	154/9376	0.832747799313149	ALDH2/NADK/GCH1/PDXK/AKR1A1/PPCS/MTHFD2/CMPK2/RDH11	-0.574923148162968
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/658	154/9376	0.832747799313149	GNAI2/CALM3/TPM3/ATP1B3/CALM1/PPP2R3C/KCNQ1/CACNA2D4/KCNE1	-0.574923148162968
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/658	56/9376	0.763352149370386	PTCH2/SPOP/CUL1	-0.487953878460507
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/658	73/9376	0.78078028063455	GSTO1/GSTK1/MGST1/ALDH3B1	-0.516558711024765
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/658	73/9376	0.78078028063455	GADD45B/CDKN1A/BAX/BAK1	-0.516558711024765
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/658	170/9376	0.838190595387091	GADD45B/GRB2/HMOX1/GSTO1/CDKN1A/BAX/ACTG1/MGST1/FRAT1/BAK1	-0.584901705822879
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/658	90/9376	0.791624451198919	SOD2/EIF4EBP1/BAX/EIF4E2/ULK1	-0.545687272324435
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/658	20/9376	0.712462006079027	LIPA	-0.353635033282996
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/658	21/9376	0.678535243884788	CHST15	-0.40514573365985
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/658	109/9376	0.784361841554893	NFKBIA/TNF/SOCS3/STAT3/CPT1A/SLC27A3	-0.622098901421954
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/658	158/9376	0.811665576545727	GADD45B/CDKN1A/CDKN2D/CDKN1B/YWHAH/ANAPC16/CUL1/MAD2L2/ANAPC15	-0.655888552657989
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/658	59/9376	0.724537633300706	GNAI2/ABHD5/CGA	-0.58309643373755
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/658	60/9376	0.712462006079027	RAC1/VEGFA/SPHK1	-0.613827408243186
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/658	23/9376	0.619532179199154	IDI1	-0.501876123011241
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/658	23/9376	0.619532179199154	CTSA	-0.501876123011241
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/658	23/9376	0.619532179199154	ATP1B3	-0.501876123011241
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/658	63/9376	0.678535243884788	GPX4/PTGES3/CBR1	-0.703313561647705
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/658	149/9376	0.765059872299627	CXCL8/GRB2/SYK/RHOA/RRAS/ARF1/RALB/SPHK1	-0.794164056202408
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/658	166/9376	0.772549163218222	GNAI2/VASP/CALM3/RHOA/ATP1B3/SLC25A6/VDAC2/CALM1/PPIF	-0.812272818589003
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/658	99/9376	0.719658591999017	CALM3/IL1B/PTGER4/CALM1/PTGER2	-0.770355560864102
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/658	99/9376	0.719658591999017	TNF/TPM3/ACTG1/EMD/CACNA2D4	-0.770355560864102
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/658	45/9376	0.633299560959135	TAP1/TAP2	-0.677397742174808
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/658	83/9376	0.686710367305087	SOD2/ACSL1/GSTK1/ACAA1	-0.787584669345019
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/658	65/9376	0.657657236380641	NR4A1/ORAI1/LDLR	-0.760868877141795
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	21/658	362/9376	0.826613377218761	NR4A1/GRB2/SGK1/MCL1/RAC1/DDIT4/CSH1/CDKN1A/SYK/EIF4EBP1/CDC37/EREG/VEGFA/CDKN1B/TLR4/EIF4E2/YWHAH/OSM/GNG5/PPP2R3C/AREG	-0.924275089969873
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/658	26/9376	0.548047696983867	ACAA1	-0.633962581206047
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/658	26/9376	0.548047696983867	TCN2	-0.633962581206047
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/658	103/9376	0.691710685513619	SAP18/PPP2R3C/ACIN1/MAGOH/ETF1	-0.864285261618406
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/658	138/9376	0.722787542399013	CALM3/YWHAH/ANAPC16/CALM1/CUL1/MAD2L2/ANAPC15	-0.901266979992408
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/658	48/9376	0.593718338399189	ATP1B3/HK1	-0.775253476784085
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/658	27/9376	0.527749634132613	ACAA1	-0.675090129033529
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/658	238/9376	0.778319838573727	GRB2/RAC1/CALM3/RAP1B/RHOA/RRAS/RAP1A/RAB5C/VEGFA/RALB/SHOC2/CALM1/GNG5	-0.95165576613392
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/658	122/9376	0.700782301061338	STAT1/HIF1A/ATP1B3/ACTG1/NOTCH1/MED4	-0.913887209689178
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/658	105/9376	0.678535243884788	TNF/TPM3/ACTG1/EMD/CACNA2D4	-0.91002825669849
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/658	28/9376	0.508901432913591	ACAA2	-0.714954630774558
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/658	51/9376	0.558793730258061	PLA2G7/LPCAT1	-0.867945579897703
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/658	144/9376	0.692671394799054	KLF4/GRB2/ID2/STAT3/SKIL/INHBA/JARID2	-1.02100174828392
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/658	110/9376	0.647692732799116	GNAI2/STK10/ANAPC16/MAD2L2/ANAPC15	-1.02108512374345
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/658	233/9376	0.733866444029899	ENO1/TPM3/TLN1/ATP1B3/VIM/VCAN/CAPZB/ACTG1/FHL3/LMNB1/TNNT1/EMD	-1.13011695378241
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/658	54/9376	0.527749634132613	LDHA/MDH2	-0.956103232121526
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/658	32/9376	0.445288753799392	LDHA	-0.863506672464044
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/658	55/9376	0.518154186239293	GM2A/SPHK1	-0.984573933411025
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/658	150/9376	0.664964539007092	GADD45B/GRB2/CDKN1A/BAX/CDKN1B/FRAT1/BAK1	-1.13637019219294
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/658	133/9376	0.642822862627694	FOS/GNAI2/CALM3/CALM1/GNG5/PPP2R3C	-1.13970682469994
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/658	254/9376	0.729291817246248	CXCR4/CALM3/PTAFR/VEGFA/GNA15/SLC25A6/CAMK1/VDAC2/ORAI1/CALM1/PPIF/CD38/SPHK1	-1.20160952011736
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/658	78/9376	0.548047696983867	TPI1/IMPA2/ITPK1	-1.1011216123236
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/658	98/9376	0.581601637615533	CALM3/IMPA2/ITPK1/CALM1	-1.1438418508395
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/658	117/9376	0.60894188553763	MBD2/BAZ1A/ACTG1/CDK2AP2/ING3	-1.16934413955883
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/658	36/9376	0.39581222559946	AKR1A1	-0.997791725540067
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/658	36/9376	0.39581222559946	HK1	-0.997791725540067
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/658	60/9376	0.474974670719352	GNAI2/CRH	-1.12080818517131
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/658	37/9376	0.385114597880555	ALDH3B1	-1.02952052576664
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/658	83/9376	0.515032775478815	CSNK2B/MAX/JARID2	-1.21916817956003
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/658	178/9376	0.640415286363171	JUN/RAC1/CSNK2B/RHOA/CACYBP/TLE3/CUL1/FRAT1	-1.3306219162436
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/658	39/9376	0.365365131322578	MTHFD2	-1.09104510857498
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/658	63/9376	0.452356829256525	ALDH2/SETD2	-1.19815582144126
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/658	106/9376	0.537707174399266	NFKBIA/GRB2/CDKN1A/CDKN1B	-1.3149837069817
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/658	86/9376	0.497066515869089	ACTG1/EMD/CACNA2D4	-1.28718826629173
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/658	65/9376	0.438438157587094	ALDH2/AKR1A1	-1.24809101838489
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/658	41/9376	0.347542441989769	GRHPR	-1.15021012485679
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/658	323/9376	0.705844711904919	GRB2/HMOX1/MCL1/DDIT4/CDKN1A/RHOA/STAT3/VIM/MARCKS/VEGFA/PIM1/CDKN1B/EZR/UBE2I/NOTCH1/BAK1	-1.47799108287287
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/658	184/9376	0.619532179199154	CXCR4/GNAI2/RAC1/CFL1/RHOA/RRAS/MYL12A/SEMA4D	-1.4318976859696
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/658	42/9376	0.339267621942394	ALDH2	-1.17898013820822
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/658	89/9376	0.480311464772378	GRB2/GNAI2/TUBA1A	-1.35328905453105
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/658	90/9376	0.474974670719352	AQP9/ATP1B3/LDLR	-1.37491966540611
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/658	68/9376	0.419095297693545	DHRS4L2/RDH11	-1.3207521116762
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/658	91/9376	0.469755168843315	GNAI2/GNG5/PDE4B	-1.39635658838305
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/658	115/9376	0.495625743359323	FOS/GNAI2/GNG5/KCNQ1	-1.49507521781627
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/658	157/9376	0.544556947321549	BIRC3/ID2/ITGB2/ACTG1/YWHAH/AREG	-1.58100103092335
NA	NA	hsa04081	Hormone signaling	9/658	219/9376	0.585585210475913	GNAI2/CSH1/RHOA/STAT3/GNA15/STAT5A/GNG5/CRH/CGA	-1.70478984209404
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/658	101/9376	0.423244756086551	GNAI2/CALM3/CALM1	-1.60097825145777
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/658	54/9376	0.263874817066306	ERCC1	-1.49033588434867
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/658	56/9376	0.254450716456795	DPM3	-1.53727854920494
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/658	191/9376	0.522223459953214	FOSB/GRB2/GNAI2/CALM3/CALM1/GNG5/CRH	-1.83270294203566
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/658	134/9376	0.425350451390464	CALM3/RHOA/MYL6/CALM1	-1.84061365518195
NA	NA	hsa04519	Cadherin signaling	18/658	404/9376	0.634867134129826	NFKBIA/ARPC3/BRK1/ARPC4/RAC1/VASP/RHOA/MYO1G/RRAS/ARPC1B/LHFPL2/VIM/KRT19/ACTG1/YWHAH/SHOC2/PSENEN/ARPC2	-2.06104336055779
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/658	115/9376	0.371719307519493	DUSP1/GNAI2/GNG5	-1.86236089727561
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/658	116/9376	0.368514830730531	GNAI2/HOMER3/GNG5	-1.88008207729193
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/658	183/9376	0.467188200707559	CSNK2B/NOP10/EIF6/RAN/FBL/SBDS	-1.99968183416937
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/658	65/9376	0.219219078793547	CGA	-1.73531315962799
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/658	66/9376	0.215897577599705	CYP19A1	-1.75614380297139
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/658	103/9376	0.276684274205448	ATP1B3/KCNQ1	-2.02780664760493
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/658	86/9376	0.16568883862303	ATP1B3	-2.13530331792569
NA	NA	hsa04382	Cornified envelope formation	6/658	217/9376	0.393988206126651	S100A9/S100A10/S100A4/KRT19/ABHD5/PPP2R3C	-2.48128737791385
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/658	104/9376	0.137011924245967	LPCAT1	-2.4312236166124
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/658	370/9376	0.423626057668611	CSH1/PTAFR/TSPO/PTGER4/S1PR4/PTGER2/CRH/LTB4R/C3AR1/CGA/UTS2	-3.10763054625631
NA	NA	hsa04082	Neuroactive ligand signaling	2/658	199/9376	0.14320844343297	GNAI2/GNG5	-3.35615108219702
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/658	449/9376	0.063471002768733	CALM3/CALM1	-5.5870400495336