category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	71/335	222/9376	8.9511362108377	RPS20/RPL23A/RPS3A/RPL13A/RPL27A/RPLP0/RPS6/RPS11/RPS10/RPS16/RPL7/RPL6/RPL31/RPL14/RPL23/RPS8/RPS17/RPS2/RPL15/RPS13/RPL9/RPL26/RPS25/RPL17/RPL3/RPL13/RPL21/RPL7A/RPL18A/RPL24/RPL36A/RPL4/RPS3/RPL10A/RPL27/RPS26/RPLP2/RPL19/UBA52/RPS4X/RPL5/RPSA/RPL8/RPL11/RPL10/RPS4Y1/RPS27A/RPL29/MRPS15/RPS9/RPL22/RPL28/RPLP1/RPS24/MRPS6/RPS5/RPL35/RPS23/MRPS35/RPL38/RPS12/RPS18/RPL32/RPS15A/RPL12/RPS19/RPS14/RPL30/MRPL51/RPL35A/MRPL17	23.0780990873703
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	68/335	238/9376	7.99658848614072	RPS20/RPL23A/RPS3A/RPL13A/RPL27A/RPLP0/RPS6/RPS11/RPS10/RPS16/RPL7/RPL6/RPL31/RPL14/RPL23/RPS8/RPS17/RPS2/RPL15/RPS13/RPL9/RPL26/RPS25/RPL17/RPL3/RPL13/RPL21/RPL7A/RPL18A/RPL24/RPL36A/RPL4/RPS3/RPL10A/RPL27/RPS26/RPLP2/RPL19/UBA52/RPS4X/RPL5/RPSA/RPL8/RPL11/RPL10/RPS4Y1/RPS27A/RPL29/RPS9/RPL22/RPL28/RPLP1/RPS24/RPS5/RPL35/RPS23/RPL38/RPS12/RPS18/RPL32/RPS15A/RPL12/RPS19/RPS14/MX1/ISG15/RPL30/RPL35A	21.0450053170042
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/335	268/9376	5.43051904655825	CALM1/TXN/UBA52/TUBA1B/VDAC1/UQCRH/SLC25A5/UBE2L3/CALM2/TUBB4B/TUBA1C/RPS27A/PSMA2/VDAC2/MT-ATP6/COX5A/PARK7/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/SLC25A6/TUBB6/GNAS/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/PSMD11/PSMD14/COX7B	14.1647952436268
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/335	275/9376	4.78341383989145	CAV1/TUBA1B/VDAC1/UQCRH/SLC25A5/TUBB4B/TUBA1C/PSMA2/VDAC2/CSNK2B/MT-ATP6/COX5A/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/SLC25A6/TUBB6/RAC1/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/PSMD11/PSMD14/COX7B	12.2576000003274
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/335	308/9376	4.36177553789494	GPX3/TUBA1B/GPX1/VDAC1/UQCRH/SLC25A5/TUBB4B/TUBA1C/PSMA2/VDAC2/MT-ATP6/COX5A/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/SLC25A6/TUBB6/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/POLR2H/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/DCTN3/PSMD11/PSMD14/COX7B	11.5475040256209
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	52/335	368/9376	3.95483452303699	HNRNPA1/ACTG1/PFN1/GPX3/SRSF3/TUBA1B/GPX1/VDAC1/UQCRH/HNRNPA3/HNRNPA2B1/TUBB4B/TUBA1C/PSMA2/MT-ATP6/COX5A/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/TUBB6/RAC1/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/DCTN3/PSMD11/PSMD14/COX7B/RAB8A	11.1312180992174
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/335	46/9376	12.1687216093446	PSMA2/PSMD8/PSMA5/PSMB4/PSMB7/PSMA3/PSME2/PSMA1/PSME1/PSMC3/PSMC1/PSMB1/PSMB2/PSMB3/PSMA7/PSMA4/PSMD4/PSMD12/PSMD11/PSMD14	14.6164318823043
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/335	480/9376	3.2652736318408	CALM1/GPX3/UBA52/TUBA1B/GPX1/VDAC1/UQCRH/SLC25A5/UBE2L3/CALM2/TUBB4B/TUBA1C/RPS27A/PSMA2/VDAC2/CSNK2B/MT-ATP6/COX5A/PARK7/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/SLC25A6/TUBB6/RAC1/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/DCTN3/PSMD11/PSMD14/COX7B/RAB8A	9.80717011033058
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	48/335	388/9376	3.46244037544238	GAPDH/CALM1/TUBA1B/VDAC1/UQCRH/SLC25A5/CALM2/TUBB4B/TUBA1C/PSMA2/VDAC2/CSNK2B/MT-ATP6/COX5A/PSMD8/PSMA5/COX8C/PSMB4/MT-ND5/PSMB7/NDUFB6/PSMA3/PSMA1/SLC25A6/TUBB6/COX7B2/PSMC3/TUBB/PSMC1/COX8A/NDUFA6/PSMB1/PSMB2/SDHB/PSMB3/PSMA7/PSMA4/COX4I1/PSMD4/NDUFB3/CYCS/PSMD12/NDUFA10/MT-ND2/NDUFA13/PSMD11/PSMD14/COX7B	9.53564032366152
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/335	144/9376	4.47031509121061	VDAC1/SLC25A5/PSMA2/VDAC2/PSMD8/PSMA5/PSMB4/PSMB7/PSMA3/PSMA1/SLC25A6/PSMC3/PSMC1/PSMB1/PSMB2/PSMB3/PSMA7/PSMA4/PSMD4/CYCS/PSMD12/PSMD11/PSMD14	8.07796680316981
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	28/335	248/9376	3.15994222436206	GAPDH/ACTG1/PFN1/DYNLL1/RPS3/TXN/TUBA1B/RHOA/ARPC2/S100A10/MYL12B/TUBB4B/TUBA1C/HSP90AB1/MYL12A/ANXA2/DYNLRB1/DYNLT1/ARPC5/ARPC3/CDC42/TUBB6/RAC1/TUBB/SKP1/CYCS/DCTN3/ARPC1A	6.6355964525861
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/335	205/9376	3.14012377138697	GAPDH/VDAC1/UQCRH/SLC25A5/VDAC2/MT-ATP6/COX5A/COX8C/PPP1CA/MT-ND5/NDUFB6/SLC25A6/RAC1/COX7B2/COX8A/NDUFA6/SDHB/COX4I1/NDUFB3/NDUFA10/MT-ND2/NDUFA13/COX7B	5.96358318946277
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/335	243/9376	2.87943001044162	HNRNPA1/SRSF3/SNRPD2/HNRNPC/HNRNPA3/SNRPD1/SNRPE/LSM3/SNRPF/SNRPC/SNRPD3/HNRNPM/SNRPB/SF3B6/SNRPG/LSM4/SNU13/LSM5/MAGOH/SF3B5/BCAS2/SNRPA1/RBM17/LSM6/ZMAT2	5.71376497324532
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/335	138/9376	3.65061648280337	UQCRH/MT-ATP6/COX5A/PPA1/COX8C/MT-ND5/NDUFB6/COX7B2/COX8A/NDUFA6/SDHB/COX4I1/NDUFB3/CYCS/NDUFA10/MT-ND2/NDUFA13/COX7B	6.0380577943508
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	23/335	227/9376	2.83579459530541	GSTO1/VDAC1/UQCRH/SLC25A5/VDAC2/MT-ATP6/COX5A/COX8C/MT-ND5/NDUFB6/SLC25A6/RAC1/COX7B2/COX8A/NDUFA6/SDHB/COX4I1/ACP1/NDUFB3/NDUFA10/MT-ND2/NDUFA13/COX7B	5.38951901887262
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/335	59/9376	4.74373893245636	GSTO1/GPX3/GPX1/RRM2/GSTP1/SMS/PRDX6/GGCT/GPX4/RRM1	5.5525607780505
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/335	85/9376	3.95125548726953	DUT/TYMS/RRM2/IMPDH2/TK1/NME1/GMPS/HPRT1/AK2/DTYMK/DCTPP1/RRM1	5.26120043665097
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	14/335	116/9376	3.37786927431807	GAPDH/ALDOA/ENO1/TPI1/PKM/GCSH/MDH1/PGAM1/SDHB/TALDO1/MDH2/ACAT2/ESD/FH	4.96033814843575
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/335	138/9376	3.04218040233614	CALM1/CDK1/CALM2/YWHAQ/YWHAH/ANAPC11/YWHAE/PPP1CA/MAD2L1/CCNE1/AURKA/FBXO5/SKP1/CCNB1/PTTG1	4.65205108916956
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/335	170/9376	2.79880597014925	ACTG1/TUBA1B/RHOA/ARPC2/MYL12B/PCNA/TUBA1C/MYL12A/YBX3/ARPC5/ARPC3/MYL6/CDC42/RAC1/RAP1A/ARPC1A/RAB8A	4.55588866905759
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/335	157/9376	2.85228633900561	UQCRH/COX5A/COX8C/NDUFB6/CDC42/RAC1/COX7B2/COX8A/NDUFA6/SDHB/COX4I1/NDUFB3/CYCS/NDUFA10/NDUFA13/COX7B	4.50521840384162
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/335	158/9376	2.83423389382203	CDK1/PCNA/YWHAQ/YWHAH/ANAPC11/YWHAE/MAD2L1/BUB3/CCNA2/CCNE1/FBXO5/SKP1/CCNB1/PTTG1/NDC80/CDCA5	4.47573858758158
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/335	47/9376	4.7639250555732	LDHA/PKM/MDH1/GLO1/LDHB/MDH2/ACAT2/FH	4.97934430156791
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/335	36/9376	5.44212271973466	PCNA/RPA3/RFC2/SSBP1/PRIM1/RNASEH2A/POLE3	5.14005980084791
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/335	253/9376	2.32311957996578	ACTG1/PFN1/UBA52/VDAC1/RHOA/ARPC2/MYL12B/RPS27A/MYL12A/ARPC5/ARPC3/UBE2N/BNIP3/CDC42/RAC1/CBX3/UBE2D3/SKP1/UBE2D2/CYCS/ARPC1A	4.10667492611336
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/335	235/9376	2.3819625277866	RPS6/ACTG1/UQCRH/MT-ATP6/COX5A/COX8C/MT-ND5/NDUFB6/GNAS/COX7B2/COX8A/NDUFA6/SDHB/COX4I1/NDUFB3/NDUFA10/MT-ND2/NDUFA13/ACTL6A/COX7B	4.12983928306945
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/335	82/9376	3.41317801237714	GSTO1/DUT/RRM2/GSTP1/IMPDH2/TK1/NME1/GMPS/HPRT1/RRM1	4.22468914485008
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/335	200/9376	2.37898507462687	GAPDH/ACTG1/RPS3/TUBA1B/RHOA/NCL/ARPC2/TUBB4B/TUBA1C/ARPC5/ARPC3/CDC42/TUBB6/RAC1/TUBB/CYCS/ARPC1A	3.79443980981346
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/335	59/9376	3.79499114596509	DUT/TYMS/RRM2/TK1/NME1/DTYMK/DCTPP1/RRM1	4.14541678575368
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/335	23/9376	6.08436080467229	PCNA/RPA3/RFC2/SSBP1/EXO1	4.69920747510911
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/335	194/9376	2.30829358362825	ACTG1/DYNLL1/TUBA1B/MYL12B/TPM3/TUBB4B/TUBA1C/TPM4/MYL12A/DYNLRB1/DYNLT1/CAPZB/MYL6/TUBB6/TUBB/DCTN3	3.54435520638183
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/335	78/9376	3.22939150401837	ACTG1/CAV1/RHOA/ARPC2/ARPC5/ARPC3/CDC42/RAC1/ARPC1A	3.80573618252282
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/335	67/9376	3.34185787480508	GAPDH/LDHA/ALDOA/ENO1/TPI1/PKM/PGAM1/LDHB	3.70293618715107
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/335	87/9376	2.89531652084406	UQCRH/TPM3/TPM4/COX5A/COX8C/COX7B2/COX8A/COX4I1/COX7B	3.4186662158887
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/335	93/9376	2.70852190659605	ACTG1/RHOA/MYL12B/MYL12A/CSNK2B/CDC42/RAC1/RAP1A/ACP1	3.1872612140946
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/335	63/9376	3.10978441127695	PCNA/RAD23B/RPA3/RFC2/POLR2H/RAD23A/POLE3	3.23417383624901
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/335	142/9376	2.16808913180576	CALM1/ACTG1/GSTO1/TXN/CAV1/RHOA/CALM2/HSP90AB1/GSTP1/SUMO2/RAC1	2.69975918475838
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/335	75/9376	2.61221890547264	GAPDH/ALDOA/ENO1/TPI1/PKM/PGAM1/TALDO1	2.69829622733078
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/335	44/9376	3.18046132971506	HMGB1/PCNA/RFC2/APEX1/POLE3	2.79053304153907
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/335	30/9376	3.73174129353234	MDH1/SDHB/MDH2/FH	2.88461005954415
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/335	78/9376	2.51174894756984	ENO1/LSM3/HSPD1/LSM4/LSM5/HSPA9/LSM6	2.58066726202521
NA	NA	hsa04517	IgSF CAM signaling	18/335	299/9376	1.68489991514002	ACTG1/DYNLL1/TUBA1B/RHOA/ARPC2/MYL12B/TUBB4B/TUBA1C/MYL12A/ARPC5/ARPC3/MYL6/CDC42/TUBB6/RAC1/TUBB/RAP1A/ARPC1A	2.31681494458135
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/335	31/9376	3.61136254212807	GCSH/MDH1/MDH2/ACAT2	2.80322637938237
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/335	157/9376	1.96094685806636	CALM1/VDAC1/SLC25A5/CDK1/CALM2/VDAC2/PPP1CA/SLC25A6/CCNA2/CCNE1/CCNB1	2.337260378651
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/335	142/9376	1.97099011982342	UBA52/UBE2L3/RPS27A/ANAPC11/UBE2I/UBE2C/UBE2N/UBE2D3/SKP1/UBE2D2	2.24421186956034
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/335	107/9376	2.09256521132654	LDHA/CALM1/PKM/CALM2/PGAM1/PYGL/GNAS/LDHB	2.18787558927134
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/335	89/9376	2.20130806640953	TUBA1B/CDK1/TUBB4B/TUBA1C/TUBB6/GNAS/TUBB	2.19185328626544
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/335	128/9376	1.96791044776119	RRM2/IMPDH2/PAICS/NME1/GMPS/HPRT1/AK2/ATIC/RRM1	2.12234537436537
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/335	54/9376	2.59148700939746	LDHA/SMS/MDH1/LDHB/MDH2	2.25759084743593
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/335	39/9376	2.87057022579411	TYMS/GCSH/DHFR/ATIC	2.25321403908183
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/335	116/9376	1.93021101389604	ACTG1/RHOA/MYL12B/MYL12A/CDC42/CD99/RAC1/RAP1A	1.94046040636396
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/335	98/9376	1.99914712153518	CFL1/ARPC2/ARPC5/ARPC3/CDC42/RAC1/ARPC1A	1.91388175527659
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/335	205/9376	1.63832544594103	PSMD8/RAC1/CCNA2/CCNE1/PSMC3/PSMC1/ISG15/PSMD4/CYCS/PSMD12/PSMD11/PSMD14	1.7787321227469
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/335	205/9376	1.63832544594103	PKM/RANBP1/RHOA/CDK1/YWHAQ/YWHAH/YWHAE/CDC42/RAC1/CCNA2/CCNE1/PSMC1	1.7787321227469
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/335	232/9376	1.56829644879053	ACTG1/PFN1/CFL1/RHOA/ARPC2/MYL12B/MYL12A/ARPC5/PPP1CA/ARPC3/CDC42/RAC1/ARPC1A	1.68713810004366
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/335	83/9376	2.0232332314332	CSNK2B/RBBP7/CBX3/UBE2D3/SKP1/UBE2D2	1.80233501860771
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/335	13/9376	4.30585533869116	XRCC5/XRCC6	2.29587276840523
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/335	30/9376	2.79880597014925	TYMS/DHFR/ATIC	1.89946749677421
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/335	108/9376	1.81404090657822	EEF1A1/RAN/UBE2I/SUMO2/KPNA2/MAGOH/SAP18	1.63781521594431
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/335	15/9376	3.73174129353234	AK2/ACP1	2.03809245668501
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/335	110/9376	1.78105834464043	CDK1/HSP90AB1/ANAPC11/MAD2L1/CCNA2/AURKA/CCNB1	1.58611063968382
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/335	224/9376	1.49936034115139	RANBP1/RAN/VDAC1/SLC25A5/VDAC2/ANAPC11/MAD2L1/BUB3/SLC25A6/CCNA2/CCNE1/PTTG1	1.45606196871324
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/335	250/9376	1.45537910447761	CAV1/RHOA/ARPC2/ARPC5/RAB11A/VPS29/ARPC3/CAPZB/SNX2/CDC42/RUFY1/ARPC1A/RAB8A	1.40476176461656
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/335	138/9376	1.62249621457928	ACTG1/RHOA/ARPC2/ARPC5/ARPC3/CDC42/RAC1/ARPC1A	1.41803544374665
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/335	117/9376	1.6744992983799	ACTG1/MORF4L2/MORF4L1/RBBP7/POLE3/ACTL6A/SMARCA1	1.41316280519631
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/335	75/9376	1.86587064676617	CDK1/RRM2/CCNE1/CCNB1/CYCS	1.44916766054216
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/335	120/9376	1.6326368159204	CALM1/RHOA/CALM2/YWHAE/CDC42/RAC1/RAP1A	1.34255850138344
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/335	56/9376	1.99914712153518	EEF1A1/BNIP3/HSPD1/CYCS	1.44349507333926
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/335	168/9376	1.49936034115139	FTH1/PPIA/HMGB1/VDAC1/SLC25A5/HSP90AB1/VDAC2/PYGL/SLC25A6	1.25714635546505
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/335	102/9376	1.64635645302897	RHOA/RAB11A/RAC1/GNAS/RAP1A/RAB8A	1.2633929125289
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/335	20/9376	2.79880597014925	UGP2/NANS	1.55007966403069
Organismal Systems	Immune system	hsa04611	Platelet activation	7/335	126/9376	1.55489220563847	ACTG1/RHOA/MYL12B/MYL12A/PPP1CA/GNAS/RAP1A	1.2070432667717
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/335	41/9376	2.04790680742628	RAD51/RPA3/SSBP1	1.29436641559495
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/335	63/9376	1.77701966358683	PTGES3/CYP2J2/HPGD/GPX4	1.19112486223297
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/335	42/9376	1.99914712153518	FTH1/VDAC2/GPX4	1.24916554135647
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/335	110/9376	1.52662143826323	GAPDH/LDHA/RPS6/ALDOA/ENO1/LDHB	1.06942057792038
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/335	44/9376	1.90827679782904	DYNLL1/RAB11A/GNAS	1.1624037448701
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/335	67/9376	1.67092893740254	CALM1/CALM2/PPP1CA/RAP1A	1.06087011856835
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/335	139/9376	1.40947063244926	KRT19/CALM1/KRT18/CALM2/HSP90AB1/KRT23/GNAS	0.936191070994871
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/335	69/9376	1.62249621457928	CALM1/CALM2/PPP1CA/GNAS	0.998978658434724
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/335	70/9376	1.59931769722815	CDC42/RAC1/RAP1A/FH	0.968778306298317
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/335	70/9376	1.59931769722815	ACTG1/CAV1/RAC1/CYCS	0.968778306298317
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/335	166/9376	1.3488221542888	CALM1/VDAC1/RHOA/SLC25A5/CALM2/VDAC2/PPP1CA/SLC25A6	0.872826846651546
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/335	216/9376	1.29574350469873	CALM1/CYP2J2/RHOA/CALM2/HSP90AB1/CDC42/HSPD1/RAC1/RAP1A/CYCS	0.846436067861472
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/335	71/9376	1.57679209585873	LDHA/PKM/PGAM1/LDHB	0.939052975347651
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/335	73/9376	1.53359231241055	PPIA/RAN/MX1/PSIP1	0.880966290226405
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/335	29/9376	1.93021101389604	CALM1/CALM2	0.965704292994881
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/335	173/9376	1.29424553532913	ACTG1/VDAC1/SLC25A5/RAB11A/SLC25A6/MX1/KPNA2/CYCS	0.751913754918867
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/335	99/9376	1.41353836876225	CALM1/CYP2J2/CALM2/PPP1CA/GNAS	0.796213315785452
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/335	75/9376	1.49269651741294	GSTO1/GSTP1/BIRC5/CYCS	0.824603377147845
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/335	149/9376	1.31487528798958	MT-ND5/NDUFB6/NDUFA6/NDUFB3/NDUFA10/MT-ND2/NDUFA13	0.745763731650769
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/335	52/9376	1.61469575200918	CYP2J2/GNAS/CYP11A1	0.855579870692748
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/335	76/9376	1.47305577376276	CALM1/ACTG1/CALM2/GNAS	0.797035153430821
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/335	203/9376	1.2408499375046	ACTG1/CAV1/RHOA/MYL12B/MYL12A/PPP1CA/CDC42/RAC1/RAP1A	0.667788087100072
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/335	54/9376	1.55489220563847	RAD51/UBE2T/RPA3	0.787137788348796
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/335	78/9376	1.43528511289705	CALM1/CFL1/RHOA/CALM2	0.743063881278788
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/335	31/9376	1.80568127106403	ALDOA/TALDO1	0.864876843404708
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/335	31/9376	1.80568127106403	SRP9/SEC11A	0.864876843404708
NA	NA	hsa04981	Folate transport and metabolism	2/335	31/9376	1.80568127106403	TYMS/DHFR	0.864876843404708
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/335	154/9376	1.27218453188602	CALM1/ACTG1/RHOA/CALM2/PPP1CA/MYL6/GNAS	0.655557891008956
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/335	32/9376	1.74925373134328	LDHA/LDHB	0.817216818291583
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/335	32/9376	1.74925373134328	BIRC5/CYCS	0.817216818291583
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/335	155/9376	1.26397688974482	ACTG1/TUBA1B/TUBB4B/TUBA1C/TUBB6/RAC1/TUBB	0.637885239403674
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/335	105/9376	1.33276474769012	UBA52/RPS27A/CSNK2B/BNIP3/BNIP3L	0.660037298407937
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/335	134/9376	1.2531967030519	CALM1/RHOA/CALM2/PPP1CA/MYL6/GNAS	0.568234071354108
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/335	212/9376	1.18817234581808	CALM1/ACTG1/PFN1/RHOA/CALM2/CDC42/RAC1/GNAS/RAP1A	0.533434372190608
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/335	35/9376	1.59931769722815	ALDOA/TPI1	0.683745128910627
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/335	137/9376	1.22575443948143	ACTG1/TUBA1B/TUBA1C/LMNB1/BIRC5/CYCS	0.512370251739398
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/335	36/9376	1.55489220563847	UGP2/PYGL	0.642075714688162
NA	NA	hsa04519	Cadherin signaling	16/335	404/9376	1.1084380079799	KRT19/ACTG1/KRT8/RHOA/ARPC2/KRT18/YWHAQ/YWHAH/ARPC5/YWHAE/KRT23/PPP1CA/ARPC3/CDC42/RAC1/ARPC1A	0.428871698797211
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/335	87/9376	1.28680734259736	RHOA/RAC1/BIRC5/CYCS	0.517327085910564
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/335	37/9376	1.51286809197257	MIF/COMT	0.601666957922014
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/335	37/9376	1.51286809197257	UGP2/NANS	0.601666957922014
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/335	37/9376	1.51286809197257	HBB/HBA2	0.601666957922014
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/335	37/9376	1.51286809197257	TPM3/TFG	0.601666957922014
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/335	93/9376	1.20378751404269	CALM1/CALM2/CDC42/GNAS	0.380167229297687
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/335	174/9376	1.12595642477269	HSP90AB1/DNAJA1/RAD23B/UBE2D3/SKP1/UBE2D2/RAD23A	0.322814951737346
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/335	41/9376	1.36527120495086	GCSH/PGAM1	0.451180178353356
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/335	16/9376	1.74925373134328	MIF	0.577365445611336
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/335	204/9376	1.09757096868598	RPS6/ACTG1/CAV1/RHOA/EIF4B/PPP1CA/CDC42/RAC1	0.271208617249408
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/335	69/9376	1.21687216093446	CALM1/CALM2/GNAS	0.348035305770607
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/335	98/9376	1.14236978373439	CALM1/CALM2/GNAS/CYP11A1	0.27271152137561
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/335	154/9376	1.09044388447374	CALM1/TPM3/CALM2/TPM4/PPP1CA/GNAS	0.217834576231861
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/335	155/9376	1.08340876263842	GNAS/CCNE1/RAP1A/CRH/CYP11A1/FH	0.20155256233
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/335	18/9376	1.55489220563847	PRDX1	0.453579234482393
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/335	183/9376	1.07058151863633	RAN/CSNK2B/FBL/SNU13/NHP2/NOP10/UTP18	0.18560416614322
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/335	156/9376	1.07646383467279	YWHAQ/YWHAH/YWHAE/MX1/EIF3E/CYCS	0.185375664112778
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/335	157/9376	1.0696073771271	ACTG1/YWHAQ/YWHAH/YWHAE/PPP1CA/BIRC5	0.169302353460385
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/335	46/9376	1.21687216093446	FTH1/BLVRA	0.283819158390918
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/335	214/9376	1.04628260566327	CALM1/CFL1/CDK1/CALM2/RAC1/SKP1/CCNB1/CYCS	0.131834583461599
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/335	19/9376	1.47305577376276	GCSH	0.397301898526516
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/335	103/9376	1.08691493986379	PPP1CA/MAGOH/ETF1/SAP18	0.170727202282563
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/335	75/9376	1.1195223880597	GPX3/GPX1/GNAS	0.200039093753532
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/335	133/9376	1.05218269554483	CALM1/CALM2/PPP1CA/GNAS/COMT	0.116666363285085
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/335	105/9376	1.0662117981521	ACTG1/TPM3/TPM4/GNAS	0.131330787526022
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/335	77/9376	1.09044388447374	RAD51/CDC42/RAC1	0.15339325116859
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/335	163/9376	1.03023532643531	PCNA/YWHAQ/CCNA2/CCNE1/BIRC5/CYCS	0.0749562300679825
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/335	50/9376	1.1195223880597	HBB/HBA2	0.163112169992563
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/335	136/9376	1.02897278314311	EIF3H/CSNK2B/CCNE1/MX1/CYCS	0.0655123972362866
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/335	51/9376	1.09757096868598	ACTG1/GNAS	0.134487243308368
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/335	195/9376	1.00469957902794	ACTG1/HMGB1/VDAC1/SLC25A5/VDAC2/SLC25A6/RAC1	0.0127653014829934
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/335	138/9376	1.01406013411205	RPS6/CALM1/CALM2/PPP1CA/PYGL	0.0320287385654083
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/335	52/9376	1.07646383467279	VDAC1/VDAC2	0.10642812735924
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/335	226/9376	0.990727777043984	CALM1/RHOA/CALM2/PPP1CA/RAC1/GNAS/RAP1A/CRH	-0.0271598486563358
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/335	82/9376	1.02395340371314	HSP90AB1/PSME2/PSME1	0.0419346124198425
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/335	23/9376	1.21687216093446	ACAT2	0.200443540291189
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/335	23/9376	1.21687216093446	MDH1	0.200443540291189
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/335	53/9376	1.05615319628274	RAB11A/GNAS	0.0789104248229697
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/335	233/9376	0.960963423227212	ENO1/ACTG1/TPM3/CSRP2/TPM4/CAPZB/LMNB1/PDLIM2	-0.116146234364733
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/335	27/9376	1.03659480375898	ACAT2	0.0366537599996958
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/335	181/9376	0.927780984579863	CALM1/RHOA/CALM2/HSPD1/HSPA9/CYCS	-0.188849044159113
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/335	60/9376	0.932935323383084	CDC42/RAC1	-0.100312378286401
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/335	60/9376	0.932935323383084	GNAS/CRH	-0.100312378286401
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/335	28/9376	0.999573560767591	DHFR	-0.00043498734656329
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/335	61/9376	0.91764130168828	FTH1/MT2A	-0.12421749557308
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/335	184/9376	0.912654120700844	CFL1/RHOA/MYL12B/MYL12A/CDC42/RAC1	-0.230327679358902
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/335	154/9376	0.908703237061446	UGP2/NME1/DHFR/AK2/RDH13	-0.219888738545235
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/335	93/9376	0.902840635532017	CALM1/CALM2/GNAS	-0.181251567661695
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/335	93/9376	0.902840635532017	CKS1B/CCNE1/CYCS	-0.181251567661695
NA	NA	hsa04382	Cornified envelope formation	7/335	217/9376	0.902840635532017	KRT19/KRT8/S100A10/KRT18/S100A9/KRT23/S100A11	-0.27873423275236
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/335	187/9376	0.898012610743076	TXN/VDAC1/RHOA/HSP90AB1/VDAC2/YWHAE	-0.271164579112721
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/335	30/9376	0.932935323383084	CYP2J2	-0.0708176287656721
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/335	97/9376	0.865610093860594	CALM1/CALM2/GNAS	-0.256095376277126
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/335	65/9376	0.861171067738232	GNAS/CYP11A1	-0.216191346076901
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/335	32/9376	0.874626865671642	UGP2	-0.136745443698193
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/335	66/9376	0.84812302125735	CYP11A1/COMT	-0.238335581442895
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/335	99/9376	0.84812302125735	KRT19/KRT18/KRT23	-0.292418991732506
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/335	99/9376	0.84812302125735	ACTG1/TPM3/TPM4	-0.292418991732506
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/335	193/9376	0.870095120253654	RHOA/CDC42/PPBP/RAC1/RAP1A/PF4	-0.35100365165479
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/335	101/9376	0.831328505984927	CALM1/CALM2/GNAS	-0.328053916188353
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/335	196/9376	0.856777337800792	CALM1/UBA52/CALM2/RPS27A/RAC1/CYCS	-0.390048169625762
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/335	34/9376	0.823178226514486	POLR2H	-0.198817714134991
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/335	34/9376	0.823178226514486	SKP1	-0.198817714134991
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/335	103/9376	0.815186204897841	SERPINB9/PRDX1/GNAS	-0.363030133029644
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/335	70/9376	0.799658848614073	GSTO1/GSTP1	-0.323845203001956
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/335	71/9376	0.788396047929367	CDC42/RAC1	-0.344504236819355
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/335	169/9376	0.828049103594454	UBA52/HMGB1/RPS27A/BNIP3/RAB8A	-0.434198713196746
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/335	105/9376	0.799658848614073	CALM1/RHOA/CALM2	-0.397375723355893
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/335	36/9376	0.777446102819237	UGP2	-0.257521102543788
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/335	106/9376	0.792114897212053	HSP90AB1/GSTP1/CCNE1	-0.414320327420052
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/335	73/9376	0.766796156205275	GSTO1/GSTP1	-0.385021898472004
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/335	38/9376	0.736527886881382	UGP2	-0.313255947451836
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/335	143/9376	0.782882788852938	SNRPD1/SSB/SNRPD3/SNRPB	-0.503605726612642
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/335	110/9376	0.763310719131615	RHOA/SKP1/INHBA	-0.480649607369965
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/335	76/9376	0.736527886881382	CALM1/CALM2	-0.443914962571732
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/335	178/9376	0.786181452289116	RHOA/CACYBP/CSNK2B/RAC1/SKP1	-0.55438118322665
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/335	79/9376	0.708558473455507	GSTO1/GSTP1	-0.500718191891497
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/335	42/9376	0.66638237384506	ACAT2	-0.417099377658789
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/335	115/9376	0.730123296560675	NACA/RHOA/GNAS	-0.56051234448661
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/335	43/9376	0.650885109337036	ACAT2	-0.441663769744894
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/335	43/9376	0.650885109337036	ACAT2	-0.441663769744894
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/335	217/9376	0.773863401884586	GSTO1/PTGES3/HSP90AB1/GNAS/BIRC5/KPNA2	-0.648748697751104
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/335	44/9376	0.636092265943012	TAF15	-0.465725551798867
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/335	44/9376	0.636092265943012	HSPD1	-0.465725551798867
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/335	254/9376	0.771324479962393	CALM1/VDAC1/SLC25A5/CALM2/VDAC2/SLC25A6/GNAS	-0.711199277642217
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/335	191/9376	0.73267171993436	CALM1/CALM2/PPP1CA/GNAS/CRH	-0.718491797769315
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/335	47/9376	0.59549063194665	PKM	-0.535130584963401
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/335	48/9376	0.583084577114428	ACAT2	-0.557409181838883
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/335	227/9376	0.739772503123151	CALM1/RHOA/CALM2/RAC1/GNAS/CYCS	-0.763974927934718
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/335	49/9376	0.571184891867195	GNAS	-0.57929120757126
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/335	50/9376	0.559761194029851	SMS	-0.600793776985593
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/335	333/9376	0.756434045986285	PKM/CDC42/CCNA2/GNAS/CCNE1/MX1/PSMC1/ISG15/HES2	-0.871128535942002
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/335	94/9376	0.59549063194665	HSP90AB1/S100A9	-0.758702536089444
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/335	238/9376	0.705581337012417	CALM1/RHOA/CALM2/CDC42/RAC1/RAP1A	-0.885580499735329
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/335	170/9376	0.658542581211589	ACTG1/GSTO1/GSTP1/ACTL6A	-0.864819225107807
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/335	98/9376	0.571184891867195	CALM1/CALM2	-0.821401967891708
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/335	57/9376	0.491018591254255	ACAT2	-0.741915592392828
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/335	100/9376	0.559761194029851	PPBP/PF4	-0.851937546823715
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/335	101/9376	0.554219003989951	CDC42/RAC1	-0.867011953367607
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/335	140/9376	0.599744136460554	RPS6/CALM1/CALM2	-0.918458558984151
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/335	59/9376	0.474373893245636	GNAS	-0.779587187285176
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/335	105/9376	0.533105899076048	CSNK2B/UBE2I	-0.926082234237808
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/335	63/9376	0.444254915896707	ACAT2	-0.851924111783067
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/335	362/9376	0.695835738434897	RPS6/CSH1/YWHAQ/YWHAH/HSP90AB1/YWHAE/EIF4B/RAC1/CCNE1	-1.13606583599731
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/335	109/9376	0.5135423798439	PPP1CA/PYGL	-0.983305538576827
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/335	68/9376	0.411589113257243	RDH13	-0.937360774089439
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/335	68/9376	0.411589113257243	CCNA2	-0.937360774089439
NA	NA	hsa04518	Integrin signaling	3/335	154/9376	0.545221942236868	ACTG1/CDC42/RAC1	-1.09533536809943
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/335	69/9376	0.405624053644819	RAC1	-0.953851399557626
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/335	115/9376	0.486748864373783	CYP2J2/GNAS	-1.06598158964449
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/335	158/9376	0.53141885509163	RPS6/RHOA/EIF4B	-1.14339110118038
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/335	72/9376	0.388723051409619	ISG15	-1.00223421101862
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/335	122/9376	0.45882065084414	CCNA2/RAB8A	-1.15812701121993
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/335	122/9376	0.45882065084414	RHOA/CDC42	-1.15812701121993
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/335	122/9376	0.45882065084414	CSH1/GNAS	-1.15812701121993
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/335	76/9376	0.368263943440691	PLIN2	-1.06439002057301
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/335	125/9376	0.447808955223881	RHOA/RAC1	-1.19632680108152
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/335	78/9376	0.358821278224263	TPI1	-1.09453949946763
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/335	78/9376	0.358821278224263	EEF1A1	-1.09453949946763
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/335	80/9376	0.349850746268657	RPS6	-1.12411258880168
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/335	83/9376	0.337205538572199	PRDX1	-1.16745394038598
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/335	83/9376	0.337205538572199	POLR2H	-1.16745394038598
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/335	133/9376	0.420873078217933	BNIP3/CCNB1	-1.29477082660003
NA	NA	hsa04081	Hormone signaling	4/335	219/9376	0.511197437470183	RHOA/CSH1/GNAS/CRH	-1.40889533597585
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/335	86/9376	0.325442554668518	GNAS	-1.20965107530568
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/335	86/9376	0.325442554668518	ACTG1	-1.20965107530568
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/335	180/9376	0.466467661691542	SRSF3/PPP1CA/CYCS	-1.39122484944327
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/335	90/9376	0.310978441127695	GNAS	-1.264269127606
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/335	90/9376	0.310978441127695	CSNK2B	-1.264269127606
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/335	91/9376	0.307561095620797	RAC1	-1.27764738306844
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/335	91/9376	0.307561095620797	GNAS	-1.27764738306844
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/335	149/9376	0.375678653711309	RHOA/GNAS	-1.47866864983349
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/335	99/9376	0.28270767375245	GNAS	-1.38105129925046
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/335	99/9376	0.28270767375245	RAC1	-1.38105129925046
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/335	103/9376	0.271728734965947	GNAS	-1.43054480365406
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/335	201/9376	0.417732234350635	HPGD/CCNA2/TAF15	-1.60626629910448
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/335	109/9376	0.25677118992195	RAC1	-1.50233232063483
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/335	109/9376	0.25677118992195	HSP90AB1	-1.50233232063483
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/335	112/9376	0.249893390191898	CYCS	-1.53720765197459
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/335	116/9376	0.241276376737005	GNAS	-1.58273029271979
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/335	122/9376	0.22941032542207	ACTG1	-1.64906646583599
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/335	323/9376	0.433251698165519	RHOA/STMN1/UBE2I/CCNE1/CDCA5	-1.99523950729067
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/335	130/9376	0.215292766934558	GNAS	-1.73421202963826
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/335	133/9376	0.210436539108966	RAC1	-1.76524988989507
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/335	142/9376	0.197099011982342	RAC1	-1.85571396722207
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/335	298/9376	0.375678653711309	CSH1/PPBP/INHBA/PF4	-2.10824478228462
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/335	144/9376	0.194361525704809	INHBA	-1.87531122669401
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/335	300/9376	0.373174129353234	STMN1/CDC42/RAC1/RAP1A	-2.1240273440739
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/335	150/9376	0.186587064676617	CCNE1	-1.93307981497298
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/335	157/9376	0.178267896187851	RAC1	-1.99865567173023
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/335	160/9376	0.174925373134328	CD99	-2.02619760208133
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/335	168/9376	0.166595593461265	CSH1	-2.09810676973856
NA	NA	hsa04082	Neuroactive ligand signaling	1/335	199/9376	0.140643516087902	GNAS	-2.35857308119154
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/335	250/9376	0.11195223880597	VPS29	-2.73946592588998
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/335	370/9376	0.151286809197257	CSH1/CRH	-3.20623720917027
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/335	449/9376	0.124668417378586	CALM1/CALM2	-3.65883486341995