category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	73/336	222/9376	9.17589017589018	RPLP0/RPS3A/RPL6/RPL23A/RPS10/RPS13/RPL14/RPS6/RPL13A/RPL19/RPL8/RPL15/RPL3/RPS8/RPL24/RPS16/RPL26/RPL9/RPS2/RPL13/RPS25/RPS20/RPL27A/RPL7A/RPL10A/RPL7/RPL18A/RPS4X/RPS3/RPS11/RPL11/RPL31/RPS26/RPL29/RPL10/RPS27A/RPS12/RPL27/UBA52/RPL22/RPLP1/RPL36A/RPSA/RPL32/RPL28/RPL4/RPS23/RPS5/RPL35/RPL17/RPL5/RPL21/RPL23/RPL12/RPS9/RPS24/RPS19/RPS14/RPLP2/RPL35A/RPS4Y1/RPS18/RPL30/RPL41/RPS15A/MRPL51/MRPS6/RPS17/RPS15/RPS7/RPL36AL/RPL38/MRPS15	23.7671520144627
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	72/336	238/9376	8.44177671068427	RPLP0/RPS3A/RPL6/RPL23A/RPS10/RPS13/RPL14/RPS6/RPL13A/RPL19/RPL8/RPL15/RPL3/RPS8/RPL24/RPS16/RPL26/RPL9/RPS2/RPL13/RPS25/RPS20/RPL27A/RPL7A/RPL10A/RPL7/RPL18A/RPS4X/RPS3/RPS11/RPL11/RPL31/RPS26/RPL29/RPL10/RPS27A/RPS12/RPL27/UBA52/RPL22/RPLP1/RPL36A/RPSA/RPL32/RPL28/RPL4/RPS23/RPS5/RPL35/RPL17/RPL5/RPL21/RPL23/RPL12/RPS9/RPS24/RPS19/RPS14/RPLP2/RPL35A/RPS4Y1/RPS18/MX1/RPL30/RPL41/RPS15A/RPS17/RPS15/RPS7/RPL36AL/RPL38/ISG15	22.4187089225778
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	54/336	268/9376	5.6226012793177	RPS27A/UBA52/CALM1/UQCRH/TUBA1C/TUBA1B/UBE2L3/TXN/VDAC1/SLC25A6/TUBB4B/PSMD8/GNAS/COX5A/SOD1/PSMB3/SLC25A5/PARK7/PSMC1/NDUFA11/COX4I1/PSMB1/PSMB7/VDAC2/CALM2/PSMB6/PSMB5/CYCS/UBC/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/TUBB6/PSMB2/COX7B/NDUFS5/PSMC4/PSMC3/NDUFA4/COX7C/SDHC/COX7B2/PSMD14/PSMA3/PSMB4/COX8C/NDUFA12/UQCR10	14.8017608417165
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/336	275/9376	5.07359307359307	CAV1/UQCRH/TUBA1C/TUBA1B/VDAC1/SLC25A6/TUBB4B/PSMD8/COX5A/CSNK2B/RAC1/SOD1/PSMB3/SLC25A5/PSMC1/NDUFA11/COX4I1/PSMB1/PSMB7/VDAC2/PSMB6/PSMB5/CYCS/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/TUBB6/PSMB2/CCL5/COX7B/NDUFS5/PSMC4/CAV2/PSMC3/NDUFA4/COX7C/SDHC/COX7B2/PSMD14/PSMA3/PSMB4/COX8C/NDUFA12/UQCR10	13.2181444902866
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/336	308/9376	4.5299938157081	GPX3/UQCRH/GPX1/CLTA/TUBA1C/TUBA1B/VDAC1/SLC25A6/TUBB4B/PSMD8/COX5A/SOD1/CLTB/PSMB3/SLC25A5/PSMC1/NDUFA11/COX4I1/PSMB1/PSMB7/VDAC2/PSMB6/PSMB5/CYCS/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/TUBB6/PSMB2/COX7B/NDUFS5/PSMC4/PSMC3/POLR2E/NDUFA4/COX7C/SDHC/COX7B2/PSMD14/PSMA3/PSMB4/COX8C/NDUFA12/UQCR10	12.1440796982638
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	54/336	368/9376	4.09472049689441	PFN1/GPX3/ACTG1/HNRNPA1/UQCRH/GPX1/TUBA1C/TUBA1B/VDAC1/TUBB4B/PSMD8/COX5A/RAC1/SOD1/PSMB3/PSMC1/NDUFA11/COX4I1/PSMB1/ACTB/PSMB7/PSMB6/PSMB5/CYCS/PSMA7/SRSF3/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/HNRNPA3/HNRNPA2B1/TUBB6/PSMB2/COX7B/NDUFS5/PSMC4/PSMC3/NDUFA4/COX7C/SDHC/COX7B2/SEC13/PSMD14/PSMA3/PSMB4/RAB8A/COX8C/NDUFA12/UQCR10	11.6762185034287
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/336	46/9376	12.1325051759834	POMP/PSMD8/PSMB3/PSMC1/PSMB1/PSME2/PSMB7/PSMB6/PSMB5/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/PSMB2/PSMC4/PSMC3/PSMD14/PSMA3/PSMB4	14.5915712912479
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/336	480/9376	3.31369047619048	GPX3/RPS27A/UBA52/CALM1/UQCRH/GPX1/TUBA1C/TUBA1B/UBE2L3/VDAC1/SLC25A6/TUBB4B/PSMD8/COX5A/CSNK2B/RAC1/SOD1/PSMB3/SLC25A5/PARK7/PSMC1/NDUFA11/COX4I1/PSMB1/PSMB7/VDAC2/CALM2/PSMB6/PSMB5/CYCS/UBC/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/TUBB6/PSMB2/COX7B/NDUFS5/PSMC4/PSMC3/NDUFA4/COX7C/SDHC/COX7B2/PSMD14/PSMA3/PSMB4/RAB8A/COX8C/NDUFA12/UQCR10	10.0322778599306
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	48/336	388/9376	3.45213549337261	GAPDH/CALM1/UQCRH/TUBA1C/TUBA1B/VDAC1/SLC25A6/TUBB4B/PSMD8/COX5A/CSNK2B/PSMB3/SLC25A5/PSMC1/NDUFA11/COX4I1/PSMB1/PSMB7/VDAC2/CALM2/PSMB6/PSMB5/CYCS/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/NDUFA13/COX6B1/NDUFA6/UQCRQ/TUBB6/PSMB2/COX7B/NDUFS5/PSMC4/PSMC3/NDUFA4/COX7C/SDHC/COX7B2/PSMD14/PSMA3/PSMB4/COX8C/NDUFA12/UQCR10	9.51042349130169
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/336	144/9376	4.45701058201058	VDAC1/SLC25A6/PSMD8/PSMB3/SLC25A5/PSMC1/PSMB1/PSMB7/VDAC2/PSMB6/PSMB5/CYCS/PSMA7/PSMA2/PSMA5/PSMD4/PSMA1/PSMB2/PSMC4/PSMC3/PSMD14/PSMA3/PSMB4	8.05944468171976
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/336	138/9376	4.04416839199448	UQCRH/COX5A/NDUFA11/COX4I1/ATP6V0E1/CYCS/NDUFA13/COX6B1/NDUFA6/UQCRQ/COX7B/NDUFS5/NDUFA4/COX7C/SDHC/COX7B2/COX8C/NDUFA12/PPA1/UQCR10	6.94528862192536
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/336	227/9376	3.19614013006083	GSTO1/UQCRH/VDAC1/SLC25A6/COX5A/RAC1/SOD1/SLC25A5/HMOX1/NDUFA11/COX4I1/VDAC2/NDUFA13/COX6B1/NDUFA6/UQCRQ/COX7B/NDUFS5/ACP1/NDUFA4/COX7C/SDHC/COX7B2/COX8C/NDUFA12/UQCR10	6.45739308557769
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/336	248/9376	3.03801843317972	GAPDH/PFN1/DYNLL1/ACTG1/RPS3/MYL12B/ANXA2/ARPC3/S100A10/MYL12A/SKP1/DYNLRB1/TUBA1C/TUBA1B/RHOA/TXN/TUBB4B/RAC1/HSP90AB1/ARPC2/ACTB/DYNLT1/CDC42/CYCS/TUBB6/RAB5C/BRK1	6.27071689556046
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/336	205/9376	3.26689895470383	GAPDH/UQCRH/VDAC1/SLC25A6/COX5A/RAC1/SLC25A5/NDUFA11/COX4I1/VDAC2/NDUFA13/COX6B1/NDUFA6/UQCRQ/COX7B/NDUFS5/NDUFA4/COX7C/SDHC/COX7B2/PPP1CA/COX8C/NDUFA12/UQCR10	6.32662084128962
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/336	157/9376	3.55474673946012	UQCRH/COX5A/RAC1/NDUFA11/COX4I1/CDC42/CYCS/NDUFA13/COX6B1/NDUFA6/UQCRQ/COX7B/NDUFS5/NDUFA4/COX7C/SDHC/COX7B2/COX8C/NDUFA12/UQCR10	6.22338736666859
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/336	138/9376	3.23533471359558	CALM1/SKP1/ANAPC11/YWHAE/CDK1/CDC20/RBX1/CALM2/PTTG1/CCNB1/YWHAQ/AURKA/CCNE1/PPP1CA/CCNB2/BUB1	5.09992968633331
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	22/336	235/9376	2.61236068895643	RPS6/ACTG1/UQCRH/GNAS/COX5A/COX20/NDUFA11/COX4I1/ACTB/NDUFA13/COX6B1/NDUFA6/UQCRQ/COX7B/NDUFS5/NDUFA4/COX7C/SDHC/COX7B2/COX8C/NDUFA12/UQCR10	4.82581133729893
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/336	78/9376	3.93528693528694	CAV1/ACTG1/ARPC3/CLTA/RHOA/RAC1/CLTB/ARPC2/ACTB/CDC42/CAV2	5.01850260188033
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/336	158/9376	2.82579867389994	SKP1/ANAPC11/YWHAE/CDK1/CDC20/RBX1/NDC80/PTTG1/CCNB1/CCNA2/AURKB/YWHAQ/CCNE1/CDCA5/CCNB2/BUB1	4.46204700031183
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/336	87/9376	3.52818828680898	UQCRH/COX5A/TPM4/COX4I1/COX6B1/UQCRQ/COX7B/COX7C/COX7B2/COX8C/UQCR10	4.56725880182718
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/336	67/9376	3.74840085287846	GAPDH/LDHA/ALDOA/TPI1/ENO1/PKM/LDHB/PGAM1/PGK1	4.35248238841798
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/336	200/9376	2.37190476190476	GAPDH/ACTG1/RPS3/ARPC3/TUBA1C/TUBA1B/RHOA/TUBB4B/RAC1/ARPC2/ACTB/EZR/CDC42/CYCS/TUBB6/NCL/BRK1	3.78079665966362
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/336	116/9376	2.88669950738916	GAPDH/ALDOA/TPI1/ENO1/PKM/TALDO1/MDH2/TKT/PGAM1/SDHC/PGK1/GCSH	3.94182463161047
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/336	59/9376	3.78369652945924	GPX3/GSTP1/GSTO1/PRDX6/GPX1/GPX4/SMS/RRM2	4.13505135605748
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/336	170/9376	2.46218487394958	ACTG1/MYL12B/ARPC3/MYL12A/MYL6/TUBA1C/TUBA1B/RHOA/RAC1/ARPC2/ACTB/EZR/CDC42/YBX3/RAB8A	3.70904689184773
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/336	75/9376	3.34857142857143	GAPDH/ALDOA/TPI1/ENO1/PKM/TALDO1/TKT/PGAM1/PGK1	3.93677545553713
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/336	157/9376	2.48832271762208	CALM1/VDAC1/SLC25A6/CDK1/SLC25A5/IGFBP3/VDAC2/CALM2/CCNB1/CCNA2/CCNE1/PPP1CA/CCNB2/EIF4EBP1	3.62556830205898
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/336	194/9376	2.3014236622484	DYNLL1/ACTG1/MYL12B/MYL12A/MYL6/DYNLRB1/TUBA1C/TUBA1B/TUBB4B/TPM4/ACTB/DYNLT1/KIF2C/TUBB6/KIFC1/CAPZB	3.53119727877627
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/336	142/9376	2.55466130114017	CAV1/ACTG1/GSTP1/GSTO1/CALM1/RHOA/TXN/RAC1/HSP90AB1/HMOX1/ACTB/CALM2/CAV2	3.59878653529166
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/336	243/9376	2.06701940035273	HNRNPA1/SNRPD2/HNRNPC/LSM3/SNRPD1/SNRPG/SNU13/RBM8A/SNRPE/SRSF3/SNRPF/SF3B6/SF3B5/HNRNPA3/SNRPB/SNRPC/MAGOH/SNRPD3	3.24892574381109
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/336	253/9376	1.98531902879729	PFN1/ACTG1/MYL12B/RPS27A/UBA52/ARPC3/MYL12A/SKP1/RHOA/VDAC1/RAC1/ARPC2/RBX1/ACTB/CDC42/CYCS/UBC/CCL5	3.06294610362563
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/336	107/9376	2.60792167334223	LDHA/PKM/CALM1/GNAS/CALM2/PYGL/LDHB/PRMT1/PGAM1/PPP4C	3.22486395855162
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/336	75/9376	2.97650793650794	CDK1/IGFBP3/CCNB1/CYCS/RRM2/CCNE1/GTSE1/CCNB2	3.31310678374888
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/336	93/9376	2.70046082949309	ACTG1/MYL12B/MYL12A/RHOA/CSNK2B/RAC1/ACTB/CDC42/ACP1	3.17713005568949
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/336	110/9376	2.53679653679654	GAPDH/LDHA/ALDOA/RPS6/ENO1/HMOX1/RBX1/LDHB/PGK1/EIF4EBP1	3.12563045227718
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	16/336	250/9376	1.78590476190476	CAV1/ARPC3/CLTA/RHOA/RAB11A/CLTB/ARF4/ARPC2/CDC42/CHMP2A/CAV2/VPS29/CAPZB/RAB8A/RAB5C/SNX2	2.4281233983289
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/336	232/9376	1.80418719211823	PFN1/ACTG1/CFL1/MYL12B/ARPC3/MYL12A/TMSB4X/RHOA/RAC1/ARPC2/ACTB/EZR/CDC42/PPP1CA/BRK1	2.39113500551062
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/336	44/9376	3.17099567099567	DYNLL1/GNAS/RAB11A/ARHGDIB/RAB5C	2.78271668674505
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/336	116/9376	2.16502463054187	ACTG1/MYL12B/MYL12A/RHOA/RAC1/ACTB/CD99/EZR/CDC42	2.43405098009367
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/336	142/9376	1.96512407780013	RPS27A/UBA52/SKP1/UBE2L3/ANAPC11/UBE2C/CDC20/RBX1/UBE2I/UBC	2.23410432454042
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/336	204/9376	1.77824463118581	RPS6/CAV1/ACTG1/CD63/RHOA/RAC1/IGF2/ACTB/EZR/CDC42/CAV2/PDCD4/PPP1CA	2.16655767990088
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/336	108/9376	2.06701940035273	EEF1A1/RAN/SAP18/RBM8A/UBE2I/KPNA2/MAGOH/SEC13	2.15011774078699
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/336	110/9376	2.02943722943723	ANAPC11/CDK1/HSP90AB1/CCNB1/CCNA2/AURKA/CCNB2/BUB1	2.09373217338454
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/336	155/9376	1.80030721966206	ACTG1/TUBA1C/TUBA1B/TUBB4B/RAC1/ACTB/ATP6V0E1/TUBB6/VAMP3/RAB5C	1.93688856181917
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/336	76/9376	2.20300751879699	ACTG1/CALM1/GNAS/ACTB/EZR/CALM2	2.03004060698063
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/336	42/9376	2.65759637188209	FTH1/GPX4/HMOX1/VDAC2	2.07558534711708
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/336	205/9376	1.63344947735192	PKM/RHOA/YWHAE/RAC1/CDK1/RANBP1/CDC20/PSMC1/CDC42/CCNA2/YWHAQ/CCNE1	1.76787529810399
NA	NA	hsa04517	IgSF CAM signaling	16/336	299/9376	1.49323140627488	DYNLL1/ACTG1/MYL12B/ARPC3/MYL12A/MYL6/TUBA1C/TUBA1B/RHOA/TUBB4B/RAC1/ARPC2/ACTB/EZR/CDC42/TUBB6	1.67103755512046
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/336	168/9376	1.6609977324263	FTH1/PPIA/VDAC1/SLC25A6/HSP90AB1/SLC25A5/VDAC2/CHMP2A/PYGL/HMGB1	1.66664466645567
Organismal Systems	Immune system	hsa04611	Platelet activation	8/336	126/9376	1.77173091458806	ACTG1/MYL12B/MYL12A/RHOA/GNAS/ACTB/VAMP8/PPP1CA	1.68132381961199
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/336	85/9376	1.96974789915966	IMPDH2/RRM2/TK1/AK2/TYMS/APRT	1.73144277267939
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/336	47/9376	2.37487335359676	LDHA/PKM/MDH2/LDHB	1.82165084287041
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/336	173/9376	1.6129920176163	ACTG1/VDAC1/SLC25A6/RAB11A/SLC25A5/MX1/ACTB/KPNA2/CYCS/CCL5	1.56886011234891
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/336	31/9376	2.70046082949309	ALDOA/TALDO1/TKT	1.82822182018722
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/336	15/9376	3.72063492063492	ACP1/AK2	2.03294597109795
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/336	89/9376	1.88121990369181	TUBA1C/TUBA1B/TUBB4B/GNAS/CDK1/TUBB6	1.61032168020442
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/336	70/9376	1.99319727891156	CAV1/ACTG1/RAC1/ACTB/CYCS	1.60795569651677
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/336	224/9376	1.49489795918367	RAN/VDAC1/ANAPC11/SLC25A6/RANBP1/SLC25A5/CDC20/VDAC2/PTTG1/CCNA2/CCNE1/CCNB2	1.44528244639717
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/336	51/9376	2.18860877684407	ACTG1/GNAS/ACTB/ATP6V0E1	1.64085672860118
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/336	71/9376	1.96512407780013	LDHA/PKM/LDHB/PGAM1/SLC16A3	1.57371178735336
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/336	52/9376	2.14652014652015	CYP2J2/CYP11A1/GNAS/CYP19A1	1.59828156992261
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/336	205/9376	1.49732868757259	PSMD8/RAC1/PSMC1/CYCS/PSMD4/CCNA2/PSMC4/PSMC3/ISG15/CCNE1/PSMD14	1.38797983617185
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/336	53/9376	2.10601976639712	CLTA/GNAS/RAB11A/CLTB	1.55666099298772
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/336	139/9376	1.60602946214457	KRT19/KRT18/CALM1/KRT23/GNAS/HSP90AB1/CALM2/KRT10	1.38773559480563
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/336	54/9376	2.06701940035273	LDHA/SMS/MDH2/LDHB	1.51595289953115
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/336	35/9376	2.39183673469388	ALDOA/TPI1/AKR1B1	1.59036457158612
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/336	75/9376	1.86031746031746	GSTP1/GSTO1/CYCS/BIRC5/TOP2A	1.44210076838411
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/336	120/9376	1.62777777777778	CALM1/RHOA/YWHAE/RAC1/CALM2/CDC42/ARHGDIB	1.33430757046334
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/336	214/9376	1.43435692033823	CFL1/CALM1/SKP1/RAC1/CDK1/RBX1/GNG11/CALM2/CCNB1/CYCS/CCNB2	1.23916617414644
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/336	20/9376	2.79047619047619	UGP2/NANS	1.54528825274772
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/336	103/9376	1.625520110957	PRDX1/SERPINB9/HSPB1/GNAS/SERPINB6/RAB5C	1.23061108076113
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/336	82/9376	1.70150987224158	GSTP1/GSTO1/IMPDH2/RRM2/TK1	1.23001509421009
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/336	154/9376	1.44959802102659	ACTG1/MYL6/CALM1/RHOA/GNAS/ACTB/CALM2/PPP1CA	1.08453420588948
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/336	63/9376	1.77173091458806	CYP2J2/PTGES3/GPX4/HPGD	1.18484743527178
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	10/336	203/9376	1.37461881304246	CAV1/ACTG1/MYL12B/MYL12A/RHOA/RAC1/ACTB/CDC42/CAV2/PPP1CA	1.04028651137971
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/336	138/9376	1.41545893719807	RPS6/CALM1/CALM2/PYGL/PPP1CA/EIF4EBP1/TRIP10	0.947872081251205
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/336	138/9376	1.41545893719807	ACTG1/ARPC3/RHOA/RAC1/ARPC2/ACTB/CDC42	0.947872081251205
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/336	46/9376	1.81987577639752	FTH1/HMOX1/BLVRA	1.07462567069633
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/336	69/9376	1.61766735679779	CALM1/GNAS/CALM2/PPP1CA	0.992762582032922
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/336	166/9376	1.34480780263913	CALM1/RHOA/VDAC1/SLC25A6/SLC25A5/VDAC2/CALM2/PPP1CA	0.86411665431525
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/336	71/9376	1.57209926224011	RAC1/ATP6V0E1/CDC42/CCL5	0.932853477840454
NA	NA	hsa04382	Cornified envelope formation	10/336	217/9376	1.28593372833004	KRT19/KRT8/KRT18/S100A11/S100A10/KRT23/S100A9/KRT7/S100A6/KRT10	0.821565675094976
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/336	195/9376	1.28791208791209	ACTG1/VDAC1/SLC25A6/RAC1/SLC25A5/ACTB/VDAC2/HMGB1/AQP9	0.783255174415554
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/336	98/9376	1.42371234207969	CFL1/ARPC3/RAC1/ARPC2/CDC42	0.812882978972268
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/336	29/9376	1.92446633825944	CALM1/CALM2	0.961224964283156
NA	NA	hsa04519	Cadherin signaling	17/336	404/9376	1.17421027817067	KRT19/KRT8/KRT18/ACTG1/ARPC3/KRT23/RHOA/YWHAE/RAC1/KRT7/ARPC2/ACTB/CDC42/YWHAQ/KRT10/PPP1CA/BRK1	0.690066406782429
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/336	99/9376	1.40933140933141	CYP2J2/CALM1/GNAS/CALM2/PPP1CA	0.789332439263999
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/336	52/9376	1.60989010989011	VDAC1/VDAC2/NPC2	0.850204093904521
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/336	149/9376	1.31096196868009	NDUFA11/GNG11/NDUFA13/NDUFA6/NDUFS5/NDUFA4/NDUFA12	0.737634485928213
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/336	30/9376	1.86031746031746	MDH2/SDHC	0.90986621202064
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/336	102/9376	1.36788048552754	RHOA/GNAS/RAB11A/RAC1/RAB8A	0.720185466144628
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/336	31/9376	1.80030721966206	MDH2/GCSH	0.860436827748455
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/336	31/9376	1.80030721966206	SRP9/SEC11A	0.860436827748455
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/336	78/9376	1.43101343101343	CFL1/CALM1/RHOA/CALM2	0.736909907846821
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/336	32/9376	1.74404761904762	UGP2/AKR1B1	0.812793772050027
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/336	32/9376	1.74404761904762	LDHA/LDHB	0.812793772050027
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/336	32/9376	1.74404761904762	CYCS/BIRC5	0.812793772050027
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/336	105/9376	1.32879818594104	RPS27A/UBA52/CSNK2B/UBC/RAB5C	0.653178428323407
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/336	33/9376	1.69119769119769	VAMP8/VAMP3	0.766808884254711
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/336	133/9376	1.25886143931257	CALM1/GNAS/GNG11/CALM2/COMT/PPP1CA	0.579639225140251
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/336	34/9376	1.64145658263305	SKP1/RBX1	0.722366928662901
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/336	83/9376	1.34480780263913	PRDX1/SOD1/ECH1/PRDX5	0.60828796520654
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/336	134/9376	1.24946695095949	MYL6/CALM1/RHOA/GNAS/CALM2/PPP1CA	0.560729619856345
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/336	212/9376	1.18463611859838	PFN1/ACTG1/CALM1/RHOA/GNAS/RAC1/ACTB/CALM2/CDC42	0.524219429838683
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/336	59/9376	1.41888619854722	RRM2/TK1/TYMS	0.622235910059099
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/336	187/9376	1.19378660555131	RHOA/TXN/VDAC1/YWHAE/HSP90AB1/VDAC2/TXNIP/CCL5	0.516037775765844
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/336	60/9376	1.3952380952381	HSPB1/RAC1/CDC42	0.592094115052768
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/336	137/9376	1.22210636079249	ACTG1/TUBA1C/TUBA1B/ACTB/CYCS/BIRC5	0.504870340384236
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/336	216/9376	1.16269841269841	CYP2J2/CALM1/RHOA/RAC1/HSP90AB1/CALM2/CDC42/CYCS/CCL5	0.466373125339262
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/336	36/9376	1.55026455026455	UGP2/AKR1B1	0.637705861808098
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/336	36/9376	1.55026455026455	UGP2/PYGL	0.637705861808098
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/336	13/9376	2.14652014652015	XRCC6	0.797474705015002
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/336	87/9376	1.28297755883963	RHOA/RAC1/CYCS/BIRC5	0.511208660001007
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/336	37/9376	1.50836550836551	MIF/COMT	0.597307286657905
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/336	37/9376	1.50836550836551	UGP2/NANS	0.597307286657905
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/336	196/9376	1.13896987366375	RPS27A/UBA52/CALM1/RAC1/GNG11/CALM2/CYCS/UBC	0.379051674427306
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/336	39/9376	1.43101343101343	TYMS/GCSH	0.519984609276893
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/336	66/9376	1.26839826839827	CYP11A1/CYP19A1/COMT	0.421840136198944
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/336	227/9376	1.10635619886721	CALM1/RHOA/GNAS/RAC1/GNG11/CALM2/CYCS/CCL5/EIF4EBP1	0.31272311532982
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/336	93/9376	1.20020481310804	CALM1/GNAS/CALM2/CDC42	0.374061382648175
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/336	67/9376	1.24946695095949	CALM1/CALM2/PPP1CA	0.395066283510398
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/336	41/9376	1.36120789779326	PGAM1/GCSH	0.446851341882859
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/336	16/9376	1.74404761904762	MIF	0.574240553897098
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/336	122/9376	1.14363778298205	CSH1/CSH2/GNAS/IGFBP3/GH2	0.307861175058734
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/336	69/9376	1.21325051759834	CALM1/GNAS/CALM2	0.342752667986785
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/336	97/9376	1.1507118311242	CALM1/GNAS/GNG11/CALM2	0.287642919385681
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/336	70/9376	1.19591836734694	RAC1/RBX1/CDC42	0.317185781230705
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/336	98/9376	1.13896987366375	CYP11A1/CALM1/GNAS/CALM2	0.266610701818886
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/336	99/9376	1.12746512746513	KRT19/KRT18/KRT23/KRT10	0.245796823037556
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/336	18/9376	1.55026455026455	PRDX1	0.450492255051778
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/336	73/9376	1.146771037182	PPIA/RAN/MX1	0.242695288020364
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/336	157/9376	1.06642402183803	ACTG1/YWHAE/ACTB/BIRC5/YWHAQ/PPP1CA	0.161809549246162
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/336	19/9376	1.468671679198	GCSH	0.394228718469265
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/336	75/9376	1.11619047619048	GPX3/GPX1/GNAS	0.194763424807595
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/336	103/9376	1.08368007397134	SAP18/RBM8A/PPP1CA/MAGOH	0.164627202969523
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/336	105/9376	1.06303854875283	ACTG1/GNAS/TPM4/ACTB	0.125230071085453
NA	NA	hsa04081	Hormone signaling	8/336	219/9376	1.01935203305066	CSH1/RHOA/CSH2/GNAS/IGF2/CRH/GNG11/GH2	0.0558654252592515
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/336	21/9376	1.32879818594104	CHST15	0.290795864420672
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/336	50/9376	1.11619047619048	HBA2/GYPC	0.158810381808127
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/336	136/9376	1.02591036414566	EIF3H/CSNK2B/MX1/CYCS/CCNE1	0.0586783707554018
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/336	193/9376	1.01208981001727	RHOA/PPBP/RAC1/GNG11/PF4/CDC42/CCL5	0.0327172581161774
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/336	79/9376	1.05967450271248	CLTA/CLTB/ATP6V0E1	0.102683816135811
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/336	110/9376	1.01471861471861	SKP1/RHOA/INHBA/RBX1	0.0299356155992745
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/336	169/9376	0.990701606086221	RPS27A/UBA52/VAMP8/UBC/HMGB1/RAB8A	-0.0235159908707972
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/336	23/9376	1.21325051759834	SSBP1	0.197401117290106
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/336	170/9376	0.984873949579832	ACTG1/GSTP1/GSTO1/IGF2/HMOX1/ACTB	-0.0383694506053215
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/336	83/9376	1.00860585197935	SKP1/CSNK2B/AURKB	0.015181895970213
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/336	174/9376	0.962233169129721	SKP1/HSP90AB1/RBX1/DNAJA1/CRYAB/SEC13	-0.0969427007609635
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/336	56/9376	0.996598639455782	EEF1A1/CYCS	-0.00492163937782937
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/336	117/9376	0.954008954008954	ACTG1/MORF4L2/ACTB/MORF4L1	-0.0965062049285918
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/336	178/9376	0.940609951845907	SKP1/RHOA/CSNK2B/RAC1/RBX1/CACYBP	-0.154222606068283
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/336	238/9376	0.93797519007603	CALM1/RHOA/RAC1/IGF2/GNG11/CALM2/CDC42/RAB5C	-0.186852711888991
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/336	181/9376	0.925019731649566	CALM1/RHOA/CALM2/CYCS/CEBPB/RAB5C	-0.196372863354861
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/336	60/9376	0.93015873015873	GNAS/CRH	-0.104627072539445
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/336	28/9376	0.996598639455782	AKR1B1	-0.00347490867330987
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/336	28/9376	0.996598639455782	ATP6V0E1	-0.00347490867330987
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/336	122/9376	0.914910226385636	CCNA2/RAB8A/RAB2A/EIF4EBP1	-0.182374283051098
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/336	61/9376	0.914910226385636	FTH1/HMOX1	-0.128535152674216
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/336	184/9376	0.909937888198758	CFL1/MYL12B/MYL12A/RHOA/RAC1/CDC42	-0.237857632323159
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/336	154/9376	0.90599876314162	CALM1/GNAS/TPM4/CALM2/PPP1CA	-0.226752681286384
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/336	362/9376	0.925019731649566	RPS6/CSH1/CSH2/YWHAE/RAC1/IGF2/HSP90AB1/GNG11/YWHAQ/CCNE1/EIF4EBP1/GH2	-0.280487531573639
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	11/336	333/9376	0.921778921778922	PKM/GNAS/MX1/PSMC1/ATP6V0E1/CDC42/CCNA2/ISG15/CCNE1/HES2/EIF4EBP1	-0.280195212858953
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/336	93/9376	0.900153609831029	CALM1/GNAS/CALM2	-0.186552351960087
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/336	93/9376	0.900153609831029	CKS1B/CYCS/CCNE1	-0.186552351960087
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/336	62/9376	0.900153609831029	SOD1/CRYAB	-0.15206566226147
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/336	94/9376	0.890577507598784	S100A9/HSP90AB1/CEBPB	-0.205551575191436
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/336	217/9376	0.900153609831029	PTGES3/GSTO1/GNAS/HSP90AB1/KPNA2/BIRC5/EIF4EBP1	-0.28688594180216
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/336	63/9376	0.885865457294029	RBX1/POLR2E	-0.175232088859979
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/336	30/9376	0.93015873015873	CYP2J2	-0.0738636777286129
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/336	30/9376	0.93015873015873	TYMS	-0.0738636777286129
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/336	157/9376	0.888686684865029	RAC1/CD24/RAB17/CEBPB/RAB5C	-0.27116029485544
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/336	158/9376	0.883062085593731	RPS6/RHOA/LAMTOR5/SEC13/EIF4EBP1	-0.285783135708317
NA	NA	hsa04981	Folate transport and metabolism	1/336	31/9376	0.900153609831029	TYMS	-0.107348164690306
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/336	250/9376	0.892952380952381	CD63/CLTA/CLTB/ATP6V0E1/VAMP8/LAMTOR5/VPS29/NPC2	-0.330733240392837
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/336	128/9376	0.87202380952381	IMPDH2/RRM2/AK2/APRT	-0.28104852743562
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/336	65/9376	0.858608058608059	CYP11A1/GNAS	-0.220523173803536
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/336	191/9376	0.87658937920718	CALM1/GNAS/CRH/GNG11/CALM2/PPP1CA	-0.332200821368199
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/336	99/9376	0.845598845598846	ACTG1/TPM4/ACTB	-0.297738793188888
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/336	163/9376	0.855974291557114	CYCS/CCNA2/BIRC5/YWHAQ/CCNE1	-0.357605630725243
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/336	100/9376	0.837142857142857	PPBP/PF4/CCL5	-0.31564397430966
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/336	226/9376	0.864306784660767	CALM1/RHOA/GNAS/RAC1/CRH/CALM2/PPP1CA	-0.398082299790111
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/336	68/9376	0.820728291316527	CCNA2/EIF4EBP1	-0.286028355110067
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/336	101/9376	0.828854314002829	CALM1/GNAS/CALM2	-0.333380923983277
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/336	34/9376	0.820728291316527	POLR2E	-0.20188420713723
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/336	70/9376	0.797278911564626	GSTP1/GSTO1	-0.328199176412326
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/336	36/9376	0.775132275132275	SSBP1	-0.260600953142732
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/336	105/9376	0.797278911564626	CALM1/RHOA/CALM2	-0.402718286152501
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/336	233/9376	0.838340486409156	ACTG1/ENO1/PDLIM2/TPM4/ACTB/CSRP2/CAPZB	-0.481732481274866
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/336	106/9376	0.789757412398922	GSTP1/HSP90AB1/CCNE1	-0.419666999954288
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/336	37/9376	0.754182754182754	HBA2	-0.288824536080152
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/336	37/9376	0.754182754182754	TFG	-0.288824536080152
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/336	73/9376	0.764514024787997	GSTP1/GSTO1	-0.389391106557117
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/336	140/9376	0.797278911564626	RPS6/CALM1/GNG11/CALM2	-0.465899287950322
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/336	38/9376	0.734335839598998	UGP2	-0.316350769179702
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/336	143/9376	0.78055278055278	SNRPD1/SSB/SNRPB/SNRPD3	-0.509797551187054
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/336	76/9376	0.734335839598998	PLIN2/UBC	-0.448300634041555
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/336	76/9376	0.734335839598998	CALM1/CALM2	-0.448300634041555
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/336	77/9376	0.724799010513296	RAC1/CDC42	-0.467464129744991
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/336	78/9376	0.715506715506716	ENO1/LSM3	-0.486402290448468
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/336	41/9376	0.680603948896632	SSBP1	-0.395125784623106
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/336	180/9376	0.775132275132275	CYCS/SRSF3/CCL5/PPP1CA/EIF4EBP1	-0.587266136398372
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/336	79/9376	0.706449668474985	GSTP1/GSTO1	-0.505121398567069
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/336	115/9376	0.727950310559006	CYP2J2/GNAS/GNG11	-0.565899453078221
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/336	115/9376	0.727950310559006	NACA/RHOA/GNAS	-0.565899453078221
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/336	80/9376	0.697619047619048	RPS6/EIF4EBP1	-0.523627477482571
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/336	183/9376	0.762425188654697	RAN/CSNK2B/SNU13/NHP2/NOP10	-0.625703190580437
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/336	82/9376	0.680603948896632	HSP90AB1/PSME2	-0.560023428655254
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/336	44/9376	0.634199134199134	HMGB1	-0.468872502552257
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/336	83/9376	0.672403901319564	CCL5/POLR2E	-0.577924173266114
NA	NA	hsa04518	Integrin signaling	4/336	154/9376	0.724799010513296	ACTG1/RAC1/ACTB/CDC42	-0.663848310345005
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/336	254/9376	0.769028871391076	CALM1/VDAC1/SLC25A6/GNAS/SLC25A5/VDAC2/CALM2	-0.719449942951544
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/336	155/9376	0.720122887864823	CYP11A1/GNAS/CRH/CCNE1	-0.677353351177453
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/336	156/9376	0.715506715506716	YWHAE/MX1/CYCS/YWHAQ	-0.69078026169403
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/336	86/9376	0.648947951273533	ACTG1/ACTB	-0.630498332309572
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/336	47/9376	0.59371833839919	PKM	-0.538306549735472
NA	NA	hsa03272	Virion - Hepatitis viruses	1/336	48/9376	0.581349206349206	CD63	-0.560595142715098
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/336	49/9376	0.569484936831876	GNAS	-0.582487305222484
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/336	90/9376	0.62010582010582	GNAS/AQP9	-0.698136937855404
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/336	50/9376	0.558095238095238	SMS	-0.604000140647302
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/336	91/9376	0.613291470434328	GNAS/GNG11	-0.71463544873625
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/336	95/9376	0.587468671679198	ATP6V0E1/CCL5	-0.77909858064377
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/336	133/9376	0.629430719656283	CCNB1/PRMT1/CCNB2	-0.829773994495379
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/336	98/9376	0.569484936831876	CALM1/CALM2	-0.825933852487878
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/336	99/9376	0.563732563732564	RAC1/EIF4EBP1	-0.841274409415331
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/336	101/9376	0.552569542668553	RAC1/CDC42	-0.8715661070527
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/336	59/9376	0.472962066182405	GNAS	-0.782890268340253
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/336	103/9376	0.541840036985668	GNAS/CCL5	-0.901356674822084
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/336	105/9376	0.531519274376417	CSNK2B/UBE2I	-0.930666643390454
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/336	323/9376	0.691139613740233	RHOA/HMOX1/EZR/UBE2I/STMN1/CCNE1/PDCD4/CDCA5	-1.0890260612152
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/336	109/9376	0.512013979903888	RAC1/CCL5	-0.987920755085551
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/336	109/9376	0.512013979903888	PYGL/PPP1CA	-0.987920755085551
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/336	65/9376	0.429304029304029	AKR1B1	-0.890090945041214
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/336	298/9376	0.655480984340045	CSH1/CSH2/PPBP/INHBA/PF4/CCL5/GH2	-1.16519148492337
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/336	68/9376	0.410364145658263	RDH13	-0.940765136729204
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/336	154/9376	0.543599257884972	UGP2/RDH13/AK2	-1.10094393940363
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/336	69/9376	0.404416839199448	RAC1	-0.957267160105488
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/336	116/9376	0.48111658456486	GNAS/GNG11	-1.08408754011219
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/336	72/9376	0.387566137566138	ISG15	-1.00568426348766
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/336	119/9376	0.468987595038015	CCL5/CEBPB	-1.12386482100279
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/336	201/9376	0.555318644870884	IGFBP3/HPGD/CCNA2/CEBPB	-1.22861262679531
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/336	122/9376	0.457455113192818	RHOA/CDC42	-1.16284519927076
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/336	122/9376	0.457455113192818	ACTG1/ACTB	-1.16284519927076
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/336	125/9376	0.44647619047619	RHOA/RAC1	-1.2010692113246
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/336	78/9376	0.357753357753358	TPI1	-1.09805838959611
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/336	78/9376	0.357753357753358	EEF1A1	-1.09805838959611
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/336	168/9376	0.498299319727891	CSH1/CSH2/GH2	-1.26499187805597
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/336	130/9376	0.429304029304029	GNAS/GNG11	-1.26319558632867
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/336	86/9376	0.324473975636766	EIF4EBP1	-1.21326177510675
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/336	86/9376	0.324473975636766	GNAS	-1.21326177510675
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/336	89/9376	0.313536650615302	HMMR	-1.25442787838632
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/336	89/9376	0.313536650615302	GNG11	-1.25442787838632
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/336	90/9376	0.31005291005291	EIF4EBP1	-1.26792558072903
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/336	90/9376	0.31005291005291	CSNK2B	-1.26792558072903
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/336	91/9376	0.306645735217164	RAC1	-1.28131524976391
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/336	149/9376	0.374560562480026	RHOA/GNAS	-1.48360810787411
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/336	99/9376	0.281866281866282	GNAS	-1.38481002564177
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/336	100/9376	0.279047619047619	CD24	-1.39732449445856
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/336	104/9376	0.268315018315018	PHOSPHO1	-1.44652239169831
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/336	109/9376	0.256006989951944	HSP90AB1	-1.50620326402032
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/336	112/9376	0.249149659863946	CYCS	-1.54111192728966
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/336	300/9376	0.465079365079365	HSPB1/RAC1/IGF2/CDC42/STMN1	-1.81540612688082
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/336	115/9376	0.242650103519669	GNG11	-1.57538827957392
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/336	133/9376	0.209810239885428	RAC1	-1.7693828075858
NA	NA	hsa04082	Neuroactive ligand signaling	2/336	199/9376	0.280449868389567	GNAS/GNG11	-1.97791803733544
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/336	142/9376	0.196512407780013	RAC1	-1.85994230771329
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/336	144/9376	0.193783068783069	INHBA	-1.87956056380647
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/336	150/9376	0.186031746031746	CCNE1	-1.93739169226794
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/336	160/9376	0.174404761904762	CD99	-2.03061223823853
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/336	370/9376	0.377091377091377	CSH1/CSH2/CRH/NPB/GH2	-2.356841057508
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/336	449/9376	0.124297380422102	CALM1/CALM2	-3.66604771888565