category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/89	47/9376	8.96581400908439	SOCS1/PKM/CACNA1G/IRS2	5.35925551062937
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/89	122/9376	5.18106465279057	PPP2R1B/PPARGC1A/PPP2R2A/CREB3/PRKAA2/IRS2	4.55035175042635
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/89	90/9376	5.85268414481898	PPARGC1A/CREB3/SOD2/PRKAA2/IRS2	4.52826524965718
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/89	62/9376	6.79666545849946	HSPA1A/SOD2/PRKAA2/IRS2	4.48279504752456
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/89	31/9376	10.1949981877492	CNDP2/ABAT/SMOX	5.01979244715412
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/89	107/9376	4.92281843956736	PPARGC1A/PKM/LDHA/CREB3/PRKAA2	3.99499807685075
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/89	333/9376	2.84725174612815	MX1/PPP2R1B/IRF9/FZD8/PKM/VEGFA/PPP2R2A/CREB3/HLA-F	3.35996579196905
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/89	71/9376	5.93511631587277	PKM/LDHA/HIF1A/MYC	4.08612169993584
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/89	88/9376	4.78855975485189	CFI/BDKRB2/PLAT/C2	3.49540330859539
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/89	54/9376	5.85268414481898	MTAP/LDHA/GCLC	3.50079978712182
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/89	156/9376	3.37654854508787	MX1/PPP2R1B/IRF9/PPP2R2A/MYC	2.93012702035339
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/89	109/9376	3.86599319657767	PPARGC1A/CREB3/PRKAA2/IRS2	2.9461967175937
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/89	61/9376	5.18106465279057	MT1A/SLC30A1/MT1X	3.20703197390262
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/89	227/9376	2.78453694995793	PTGER2/VEGFA/CREB3/MYC/HLA-F/ARHGEF11	2.66437026554634
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/89	168/9376	3.13536650615302	SOCS1/GH2/IRF9/PIAS2/MYC	2.73392962279607
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/89	122/9376	3.45404310186038	SOCS1/GH2/CREB3/IRS2	2.67079326714526
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/89	70/9376	4.51492776886035	PPARGC1A/PRKAA2/IRS2	2.88952741598325
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/89	125/9376	3.37114606741573	BDKRB2/PPP2R1B/ORMDL2/PPP2R2A	2.61253365022149
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/89	250/9376	2.5283595505618	DEPTOR/VPS13A/CTSH/SLC15A4/IDS/AP1S1	2.39771867595531
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/89	73/9376	4.32938279205787	MX1/ELL/SAMHD1	2.79548115471938
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/89	32/9376	6.58426966292135	LDHA/ABAT	3.09754678842094
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/89	133/9376	3.16837036411253	STK4/SOD2/PRKAA2/IRS2	2.46544731119162
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/89	196/9376	2.68745700527402	IRF9/VEGFA/HIF1A/MYC/HLA-F	2.33712709356454
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/89	138/9376	3.05357433642729	SOCS1/PPARGC1A/PRKAA2/IRS2	2.37905187177323
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/89	82/9376	3.85420663195396	RFXANK/HSPA1A/HLA-F	2.54117118309622
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/89	204/9376	2.58206653447896	SHH/FZD8/VEGFA/HIF1A/MYC	2.23640638451532
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/89	205/9376	2.56947108796931	IRF9/PKM/CREB3/GTF2H1/HLA-F	2.22415383552194
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/89	144/9376	2.92634207240949	PPARGC1A/LPIN3/PRKAA2/C2	2.28039288272523
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/89	37/9376	5.6945034922563	ADSL/ABAT	2.80080749250369
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/89	362/9376	2.03712210565522	PPP2R1B/GH2/VEGFA/PPP2R2A/CREB3/MYC/PRKAA2	1.97000948989676
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/89	41/9376	5.13894217593861	VEGFA/MYC	2.5999622661204
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/89	154/9376	2.73631985991537	ALAD/ADSL/AK4/GCLC	2.12676964427719
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/89	42/9376	5.01658640984484	SLC39A14/GCLC	2.55382291890812
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/89	157/9376	2.68403349316539	PPP2R1B/FZD8/PPP2R2A/MYC	2.08305895820974
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/89	158/9376	2.66704593941118	DEPTOR/FZD8/LPIN3/PRKAA2	2.06871507079874
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/89	44/9376	4.78855975485189	CCNH/GTF2H1	2.46578969616484
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/89	44/9376	4.78855975485189	AQP3/CREB3	2.46578969616484
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/89	166/9376	2.53851360498172	BDKRB2/PPIF/CREB3/IRS2	1.95780074173945
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/89	47/9376	4.4829070045422	PKM/LDHA	2.34323680364813
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/89	103/9376	3.06839751281772	BDKRB2/PPP2R1B/PPP2R2A	2.06626209179528
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/89	169/9376	2.49345123329566	DEPTOR/HIF1A/PRKAA2/IRS2	1.91786593507344
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/89	49/9376	4.29993120843843	B4GALT1/GALNT13	2.26712182027148
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/89	50/9376	4.21393258426966	CNDP2/SMOX	2.23057575863356
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/89	174/9376	2.42180033578716	DNAJC5/HSPA1A/PPP1R15A/HYOU1	1.8531690606585
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/89	110/9376	2.87313585291113	VEGFA/LDHA/HIF1A	1.93447174147948
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/89	178/9376	2.36737785633127	FZD8/MCC/CBY1/MYC	1.80299598588416
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/89	112/9376	2.82182985553772	SOCS1/HSPA1A/PPIF	1.89871801836752
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/89	180/9376	2.34107365792759	EIF2B3/IRF9/HLA-F/SRPK1	1.77841176172932
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/89	59/9376	3.5711293087031	ABHD5/IRS2	1.93934375405774
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/89	63/9376	3.34439093989656	CCNH/GTF2H1	1.8276727064183
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/89	63/9376	3.34439093989656	SHH/FZD8	1.8276727064183
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/89	128/9376	2.46910112359551	ADSL/AK4/ADPRM	1.6382330526806
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/89	14/9376	7.52487961476725	B4GALT1	2.3916362173369
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/89	65/9376	3.24148660328436	CACNA1G/CREB3	1.77516031884011
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/89	65/9376	3.24148660328436	CACNA1G/TRPC4	1.77516031884011
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/89	205/9376	2.05557687037545	PSMC4/IRF9/MYC/HLA-F	1.49589588679298
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/89	133/9376	2.3762777730844	PPP2R1B/PPP2R2A/CREB3	1.56483430656573
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/89	67/9376	3.14472580915646	PKM/LDHA	1.72464845212546
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/89	15/9376	7.02322097378277	AK4	2.28536842112302
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/89	136/9376	2.32385988103106	MX1/IRF9/HSPA1A	1.52236366047959
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/89	70/9376	3.0099518459069	VEGFA/HIF1A	1.65232725833146
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/89	140/9376	2.25746388443018	PPARGC1A/PLAT/PRKAA2	1.46744047968442
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/89	17/9376	6.1969596827495	CA12	2.09943292290294
NA	NA	hsa04382	Cornified envelope formation	4/89	217/9376	1.94190441671413	S100A16/PPP2R1B/ABHD5/PPP2R2A	1.37421786312324
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/89	142/9376	2.22566861845229	VEGFA/PLAT/PRKAA2	1.44067235489878
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/89	300/9376	1.75580524344569	HSPA1A/STK4/CACNA1G/VEGFA/MYC	1.30246542383739
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/89	18/9376	5.85268414481898	MCAT	2.01729622312989
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/89	388/9376	1.62909764855786	PSMC4/FZD8/SNCA/PPIF/SLC39A14/IRS2	1.23892584151351
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/89	19/9376	5.54464813719692	IDS	1.94111680169438
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	5/89	308/9376	1.7101999124471	PSMC4/PPARGC1A/PPIF/CREB3/SOD2	1.24063244802108
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	4/89	227/9376	1.85635796663862	PPIF/VEGFA/HIF1A/SOD2	1.27856960486554
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/89	150/9376	2.10696629213483	SHH/FZD8/MYC	1.33787709857152
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/89	154/9376	2.05223989493652	PPP2R1B/PPP2R2A/CREB3	1.28885922387451
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/89	155/9376	2.03899963754984	FZD8/CACNA1G/CREB3	1.27683609966294
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/89	83/9376	2.53851360498172	DDX41/SAMHD1	1.37817807760719
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/89	157/9376	2.01302511987404	ATP11A/PTGER2/HIF1A	1.25305764963065
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/89	158/9376	2.00028445455838	PPP2R1B/CCNH/MYC	1.2412996410654
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/89	22/9376	4.78855975485189	CNDP2	1.74152501868848
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/89	85/9376	2.4787838730998	ADSL/AK4	1.34068224297642
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/89	23/9376	4.58036150464094	B4GALT1	1.6828997604768
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/89	23/9376	4.58036150464094	PDSS2	1.6828997604768
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/89	170/9376	1.85908790482485	PPP2R1B/PPP2R2A/PRKAA2	1.10654606665276
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/89	254/9376	1.65902857648412	BDKRB2/PPIF/CACNA1G/VEGFA	1.04236300632645
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/89	27/9376	3.90178942987932	ABAT	1.47811462927526
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/89	28/9376	3.76243980738363	B4GALT1	1.43303040891746
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/89	98/9376	2.14996560421922	CACNA1G/CREB3	1.12024657085947
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/89	99/9376	2.12824877993417	BDKRB2/PTGER2	1.10474389511836
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/89	99/9376	2.12824877993417	CFI/C2	1.10474389511836
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/89	101/9376	2.08610523973746	FZD8/CREB3	1.07428263412608
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/89	268/9376	1.57236290457823	PSMC4/SNCA/PPIF/SLC39A14	0.930615504312446
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/89	103/9376	2.04559834187848	PPP2R1B/PPP2R2A	1.04451886239427
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/89	104/9376	2.02592912705272	LPIN3/ADPRM	1.02988856685996
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/89	32/9376	3.29213483146067	B4GALT1	1.2714276556094
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/89	275/9376	1.5323391215526	PSMC4/HSPA1A/PPIF/CREB3	0.877108040211696
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/89	106/9376	1.9877040491838	PLAT/CREB3	1.00111234890764
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/89	34/9376	3.09847984137475	PRKAA2	1.19996132092606
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/89	110/9376	1.91542390194076	PPP2R1B/MYC	0.945399484520617
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/89	36/9376	2.92634207240949	GALNT13	1.13358513170293
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/89	37/9376	2.84725174612815	MYC	1.10209664123811
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/89	115/9376	1.83214460185638	CREB3/ARHGEF11	0.878944994196935
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/89	38/9376	2.77232406859846	NNMT	1.07164493980089
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/89	38/9376	2.77232406859846	RFXANK	1.07164493980089
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/89	39/9376	2.7012388360703	HLA-F	1.04216583359315
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/89	122/9376	1.72702155093019	PPP2R1B/PPP2R2A	0.791234783864171
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/89	122/9376	1.72702155093019	HIF1A/MYC	0.791234783864171
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/89	214/9376	1.47684553187021	AP1S1/HLA-F/SAMHD1	0.690768268346198
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/89	217/9376	1.4564283125356	VEGFA/CREB3/MYC	0.66591888645107
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/89	44/9376	2.39427987742594	B4GALT1	0.907469111691832
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/89	44/9376	2.39427987742594	HLA-F	0.907469111691832
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/89	45/9376	2.34107365792759	HLA-F	0.882749972848518
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/89	130/9376	1.62074330164218	VEGFA/CREB3	0.697669427446312
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/89	46/9376	2.29018075232047	ALAD	0.858680442180228
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/89	46/9376	2.29018075232047	PSMC4	0.858680442180228
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/89	224/9376	1.41091492776886	CREB3/MYC/HLA-F	0.609341617180864
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/89	323/9376	1.30462309110516	SOCS1/VEGFA/MYC/IRS2	0.545394482984604
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/89	48/9376	2.19475655430712	ABAT	0.812360298345766
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/89	49/9376	2.14996560421922	CREB3	0.790050443239625
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/89	139/9376	1.51580308786679	HSPA1A/CREB3	0.599747967411267
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/89	235/9376	1.34487210136266	PPARGC1A/CREB3/PRKAA2	0.524128841725129
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/89	142/9376	1.48377907896819	SOCS1/PIAS2	0.568642400119506
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/89	142/9376	1.48377907896819	SOCS1/IRF9	0.568642400119506
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/89	238/9376	1.32791993201775	MX1/IRF9/C2	0.501618604556259
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/89	53/9376	1.9877040491838	BDKRB2	0.705878323653267
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/89	144/9376	1.46317103620474	FZD8/MYC	0.548299260849683
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/89	144/9376	1.46317103620474	PSMC4/PPIF	0.548299260849683
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/89	54/9376	1.95089471493966	HLA-F	0.685989839085272
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/89	148/9376	1.42362587306408	FZD8/MYC	0.508513468820534
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/89	56/9376	1.88121990369181	B4GALT1	0.647460493381312
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/89	56/9376	1.88121990369181	SHH	0.647460493381312
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/89	56/9376	1.88121990369181	HSPA1A	0.647460493381312
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/89	57/9376	1.84821604573231	MCAT	0.628785002393932
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/89	59/9376	1.78556465435155	GCLC	0.592533366823805
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/89	59/9376	1.78556465435155	MYC	0.592533366823805
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/89	60/9376	1.75580524344569	VEGFA	0.574928323651214
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/89	60/9376	1.75580524344569	PPP2R1B	0.574928323651214
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/89	157/9376	1.3420167465827	MYC/HLA-F	0.423056341051564
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	2/89	157/9376	1.3420167465827	PRKAA2/IRS2	0.423056341051564
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/89	160/9376	1.31685393258427	SLITRK4/HLA-F	0.395722531541912
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/89	163/9376	1.29261735713793	CREB3/MYC	0.368923456452556
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/89	65/9376	1.62074330164218	LPIN3	0.491601812674855
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/89	68/9376	1.54923992068738	MYC	0.44497056540603
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/89	170/9376	1.2393919365499	FZD8/MYC	0.308348196139122
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/89	69/9376	1.52678716821365	PTGER2	0.429930043617602
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/89	69/9376	1.52678716821365	CREB3	0.429930043617602
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/89	70/9376	1.50497592295345	HLA-F	0.415127100679665
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/89	173/9376	1.21789959082938	MX1/IRF9	0.28317680278219
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/89	71/9376	1.48377907896819	SOCS1	0.400553921330892
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/89	73/9376	1.44312759735262	STK4	0.372067414564149
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/89	75/9376	1.40464419475655	PKM	0.344414987924293
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/89	75/9376	1.40464419475655	PERP	0.344414987924293
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/89	75/9376	1.40464419475655	CREB3	0.344414987924293
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/89	76/9376	1.38616203429923	PLIN2	0.330885559641311
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/89	77/9376	1.36815992995768	VEGFA	0.317546021718351
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/89	77/9376	1.36815992995768	MYC	0.317546021718351
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/89	184/9376	1.14509037616023	SHH/TRPC4	0.194574278656487
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/89	78/9376	1.35061941803515	PI4K2A	0.304390724080153
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/89	78/9376	1.35061941803515	TOB1	0.304390724080153
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/89	78/9376	1.35061941803515	C2	0.304390724080153
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/89	80/9376	1.31685393258427	VEGFA	0.278611447362233
NA	NA	hsa04517	IgSF CAM signaling	3/89	299/9376	1.05700650107099	EPB41L3/TRIO/SLITRK4	0.098068996418835
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/89	83/9376	1.26925680249086	CBX4	0.241196321721135
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/89	83/9376	1.26925680249086	SOD2	0.241196321721135
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/89	86/9376	1.22498040240397	MYC	0.205177142261532
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/89	86/9376	1.22498040240397	CREB3	0.205177142261532
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/89	87/9376	1.21090016789358	MYC	0.193461695266915
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/89	201/9376	1.04824193638549	PLAT/MYC	0.0676803572797313
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/89	89/9376	1.18368892816564	ABAT	0.170444573625685
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/89	90/9376	1.1705368289638	HIF1A	0.159135845923121
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/89	93/9376	1.13277757641658	CST2	0.12596936932146
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/89	93/9376	1.13277757641658	MYC	0.12596936932146
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/89	95/9376	1.10892962743938	VEGFA	0.104460801398942
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/89	97/9376	1.08606509903857	CACNA1G	0.083407532116721
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/89	98/9376	1.07498280210961	PI4K2A	0.0730449907619235
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	2/89	216/9376	0.975447357469829	HSPA1A/SOD2	-0.0357371815412801
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/89	99/9376	1.06412438996709	HIF1A	0.0627884821186876
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/89	99/9376	1.06412438996709	PRKAA2	0.0627884821186876
NA	NA	hsa04081	Hormone signaling	2/89	219/9376	0.962085064901749	GH2/IRS2	-0.0555774588748574
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/89	101/9376	1.04305261986873	VEGFA	0.0425839782246025
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/89	103/9376	1.02279917093924	SLC15A1	0.0227756329932605
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/89	105/9376	1.00331728196897	HIF1A	0.00334623676024619
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/89	105/9376	1.00331728196897	IRF9	0.00334623676024619
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/89	226/9376	0.932285969971164	PTGER2/CREB3	-0.100870750729701
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/89	109/9376	0.966498299144418	IRF9	-0.0344392307743032
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/89	109/9376	0.966498299144418	HIF1A	-0.0344392307743032
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/89	238/9376	0.885279954678501	STK4/VEGFA	-0.175487073001974
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/89	115/9376	0.916072300928188	CREB3	-0.0886478513578922
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/89	116/9376	0.908175125920186	PKM	-0.0974152078479096
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/89	117/9376	0.900412945356766	MEAF6	-0.106110093097612
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/89	480/9376	0.877902621722846	PSMC4/FZD8/SNCA/PPIF	-0.26882675456766
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/89	119/9376	0.885279954678501	CREB3	-0.123287934718968
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/89	370/9376	0.854175523838445	BDKRB2/GH2/PTGER2	-0.280161358398593
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/89	250/9376	0.842786516853933	HSPA1A/HLA-F	-0.246639414470731
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/89	134/9376	0.786181452289116	ARHGEF11	-0.244038142820113
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/89	137/9376	0.768965800049209	CTSH	-0.266665598075338
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/89	138/9376	0.763393584106823	PPP2R1B	-0.274106920124218
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/89	143/9376	0.736701500746444	C2	-0.310590310876607
NA	NA	hsa04518	Integrin signaling	1/89	154/9376	0.684079964978841	VEGFA	-0.386961616930844
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/89	154/9376	0.684079964978841	PRKAA2	-0.386961616930844
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/89	155/9376	0.679666545849946	HLA-F	-0.393660693812219
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/89	168/9376	0.627073301230605	IRF9	-0.477461525203923
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/89	181/9376	0.582034887330064	RFXANK	-0.55583561721209
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/89	187/9376	0.563359971159046	IRF9	-0.590409236762177
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/89	191/9376	0.551561856579799	CREB3	-0.612946497764927
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/89	195/9376	0.540247767214059	PPIF	-0.63509556180524
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/89	200/9376	0.526741573033708	ARHGEF11	-0.662261593867453
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/89	203/9376	0.518957214811535	VEGFA	-0.678295516354872
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/89	205/9376	0.513894217593861	PPIF	-0.688877959393893
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/89	212/9376	0.496926012295951	VEGFA	-0.725270763536626
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/89	232/9376	0.454087562960093	BDKRB2	-0.824217423566683
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/89	243/9376	0.43353215887548	HSPA1A	-0.87581945134701
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/89	248/9376	0.424791591156216	MYC	-0.898682261936273
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/89	253/9376	0.416396500421903	GLMN	-0.921196394253367
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/89	298/9376	0.353517834250811	GH2	-1.11022885432763
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/89	368/9376	0.286272594040059	PSMC4	-1.36736674234297
NA	NA	hsa04519	Cadherin signaling	1/89	404/9376	0.260763154967182	FZD8	-1.48686854408716