category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	27/165	268/9376	5.72483039348711	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/DUSP1/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/SNCA/MT-ND4L/UBB/PSMA4/CALM1/PSMA1/MT-ATP8/PARK7/COX5A/PSMB2/TUBA1B/TUBA4A/TUBB4B/COX8A/SLC25A5	10.5030716584493
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	29/165	368/9376	4.47799736495389	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/GPX1/MT-ND3/UQCRH/ACTG1/MT-ND4L/HNRNPA3/HNRNPA2B1/MAP1LC3B/PSMA4/HNRNPA1/PSMA1/RAC1/MT-ATP8/COX5A/PSMB2/SRSF3/TUBA1B/TUBA4A/TUBB4B/COX8A	9.10989116163598
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	25/165	275/9376	5.16584022038568	MT-ND2/MT-CYB/EGR1/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/MT-ND4L/IL1B/PSMA4/PSMA1/RAC1/MT-ATP8/COX5A/PSMB2/TUBA1B/TUBA4A/TUBB4B/COX8A/SLC25A5	9.38422944093141
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	31/165	480/9376	3.66989898989899	MT-ND2/MT-CYB/MT-CO1/PTGS2/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/GPX1/MT-ND3/UQCRH/SNCA/MT-ND4L/UBB/MAP1LC3B/IL1B/PSMA4/CALM1/PSMA1/RAC1/MT-ATP8/PARK7/COX5A/PSMB2/TUBA1B/TUBA4A/TUBB4B/COX8A/SLC25A5	8.03696878876256
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/165	227/9376	5.25686824189027	FOS/MT-ND2/MT-CYB/MT-CO1/MT-ATP6/NFKBIA/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/JUN/MT-ND4L/HIF1A/RAC1/MT-ATP8/COX5A/COX8A/SLC25A5	8.6894150561264
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/165	388/9376	3.95426429240862	MT-ND2/MT-CYB/MT-CO1/PTGS2/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/SNCA/MT-ND4L/IL1B/PSMA4/CALM1/GAPDH/PSMA1/MT-ATP8/COX5A/PSMB2/TUBA1B/TUBA4A/TUBB4B/COX8A/SLC25A5	7.95440858908992
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	16/165	138/9376	6.58831796223101	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/MT-ND4L/COX17/MT-ATP8/COX5A/COX8A	8.85127617894892
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/165	205/9376	5.26663710273466	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/MT-ND4L/GAPDH/RAC1/MT-ATP8/COX5A/PPP1CA/COX8A/SLC25A5	8.26663016816792
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/165	308/9376	4.24336875245966	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/GPX1/MT-ND3/UQCRH/MT-ND4L/PSMA4/PSMA1/MT-ATP8/COX5A/PSMB2/TUBA1B/TUBA4A/TUBB4B/COX8A/SLC25A5	7.7462257567425
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/165	238/9376	4.29763177998472	FOS/CXCL8/NFKBIA/RPL36A/RPS10/JUN/RPL14/RPL7/RPL17/RPL5/RPL8/IL1B/RPL9/RPS17/RPL27/RPSA/RPS5/RPL41	6.89666737685258
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/165	94/9376	6.64964539007092	FOS/CXCL8/PTGS2/NFKBIA/CEBPB/JUND/FOSB/JUN/HSP90AB1/IL1B/CXCL1	7.3678122991006
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/165	235/9376	4.11068987749839	MT-ND2/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND5/MT-ND4/MT-ND1/MT-CO2/MT-ND3/UQCRH/ACTG1/MT-ND4L/COX17/MT-ATP8/COX5A/COX8A	6.46350384922518
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/165	157/9376	4.70519204786721	FOS/MT-CYB/MT-CO1/CXCL8/MT-CO3/MT-CO2/UQCRH/JUN/SOCS3/IL1B/RAC1/COX5A/COX8A	6.26603564616594
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/165	243/9376	3.74151390447687	DDX5/HNRNPA3/HNRNPA1/SRSF2/HNRNPC/SF3B6/SRSF5/SRSF3/SNRPD2/SNRPD1/SNRPB/LSM5/SNRPE/LSM3/LSM7/SNRPD3	5.79510194136364
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/165	119/9376	5.25266106442577	FOS/JUNB/PTGS2/NFKBIA/CEBPB/JUN/SOCS3/IL1B/CXCL1/MAP3K8/BCL3	6.24846496324013
Genetic Information Processing	Translation	hsa03010	Ribosome	15/165	222/9376	3.83947583947584	RPL36A/RPS10/RPL14/RPL7/RPL17/RPL5/RPL8/RPL9/MRPL51/RPS17/MRPL27/RPL27/RPSA/RPS5/RPL41	5.73038010099729
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/165	105/9376	4.87064935064935	PTGS2/NFKBIA/LSP1/JUN/IL1B/CALM1/EGR3/BCL3/PLK3	5.33813321679166
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/165	248/9376	3.20782013685239	FOS/CXCL8/NFKBIA/ACTG1/JUN/DYNLL1/HSP90AB1/IL1B/GAPDH/RAC1/RHOB/TUBA1B/TUBA4A/TUBB4B	4.71602321150093
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/165	87/9376	5.22521769418321	MT-CYB/MT-CO1/MT-CO3/MT-CO2/UQCRH/TPM3/COX5A/COX8A	5.2990553257203
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/165	196/9376	3.47903525046382	FOS/CXCL8/PTGS2/NFKBIA/ZFP36/JUN/UBB/MAP1LC3B/HIF1A/CALM1/RAC1/CXCL1	4.69422191333037
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/165	142/9376	4.00170721297482	FOS/DUSP1/KLF2/ACTG1/SUMO2/JUN/HSP90AB1/IL1B/CALM1/RAC1	4.82382767782464
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/165	200/9376	3.40945454545455	FOS/CXCL8/NFKBIA/ACTG1/JUN/IL1B/MYH9/GAPDH/RAC1/TUBA1B/TUBA4A/TUBB4B	4.60979117604273
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/165	78/9376	5.0996114996115	BTG2/PABPC1/BTG1/ENO1/LSM5/LSM3/LSM7	4.8659702822705
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/165	142/9376	3.60153649167734	FOS/JUNB/NFKBIA/JUND/FOSB/JUN/SOCS3/IL1B/RAC1	4.18074210541907
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/165	67/9376	5.0887381275441	LDHA/TPI1/PGK1/GAPDH/ENO1/PKM	4.49520395746217
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/165	50/9376	5.68242424242424	CXCL8/HBA2/HBA1/IL1B/HBB	4.44306099518115
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/165	105/9376	3.78828282828283	GABARAPL2/BNIP3L/JUN/UBB/MAP1LC3B/HIF1A/GABARAP	3.84540779468162
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/165	137/9376	3.31820393718204	FOS/NFKBIA/ACTG1/JUN/BCL2A1/MCL1/TUBA1B/TUBA4A	3.65825233328296
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/165	109/9376	3.64926327495135	FOS/CXCL8/NFKBIA/JUN/IL1B/RAC1/MAP3K8	3.72342839004677
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/165	37/9376	6.14316134316134	HBA2/HBA1/IL1B/HBB	4.19522291326388
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/165	187/9376	2.734856587263	CXCL8/NFKBIA/GABARAPL2/JUN/HSP90AB1/MAP1LC3B/IL1B/GABARAP/CXCL1	3.20718842700177
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/165	224/9376	2.53679653679654	FOS/EGR1/NFKBIA/ZFP36/JUN/TLN1/RAN/ANAPC11/ETS2/SLC25A5	3.11570689770583
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/165	69/9376	4.11769872639438	FOS/FOSB/JUN/CALM1/PPP1CA	3.47878871939502
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/165	71/9376	4.00170721297482	CXCL8/NFKBIA/JUN/RAC1/CXCL1	3.39792300358025
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/165	75/9376	3.78828282828283	TPI1/PGK1/GAPDH/ENO1/PKM	3.24471721376604
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/165	105/9376	3.24709956709957	CXCL8/PTGS2/NFKBIA/BCL2A1/IL1B/CXCL1	3.0990450836266
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/165	138/9376	2.88238910847607	FOS/CXCL8/NFKBIA/ACTG1/JUN/IL1B/RAC1	2.98149568223841
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/165	78/9376	3.64257964257964	FOS/CXCL8/JUN/IL1B/CALM1	3.13656891891929
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/165	78/9376	3.64257964257964	FOS/PTGS2/NFKBIA/JUN/IL1B	3.13656891891929
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/165	109/9376	3.1279399499583	FOS/NFKBIA/JUN/HSP90AB1/IL1B/HIF1A	2.99073032752282
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/165	253/9376	2.24601748712421	CXCL8/NFKBIA/ACTG1/JUN/TLN1/UBB/MAP1LC3B/IL1B/RAC1/UBE2D1	2.68899366917823
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/165	216/9376	2.36767676767677	FOS/CXCL8/NFKBIA/JUN/HSP90AB1/IL1B/CALM1/RAC1/CXCL1	2.72167853172417
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/165	149/9376	2.66959528167582	MT-ND2/PTGS2/MT-ND5/MT-ND4/MT-ND1/MT-ND3/MT-ND4L	2.74946567229257
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/165	56/9376	4.05887445887446	CXCL8/NFKBIA/IL1B/CXCL1	3.07271251788241
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/165	95/9376	2.99074960127592	FOS/CXCL8/JUN/IL1B/CXCL1	2.61008873866483
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/165	169/9376	2.35366684597454	GABARAPL2/HMGB1/DDIT4/UBB/MAP1LC3B/HIF1A/GABARAP	2.37667770495882
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/165	101/9376	2.81308130813081	EGR1/CXCL8/JUN/IL1B/RAC1	2.45185750993186
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/165	103/9376	2.75845837010886	ETF1/SAP18/PABPC1/GSPT1/PPP1CA	2.40167807205251
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/165	103/9376	2.75845837010886	FOS/CXCL8/NFKBIA/JUN/IL1B	2.40167807205251
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/165	139/9376	2.45284499672989	FOS/JUN/KRT19/HSP90AB1/CALM1/KRT18	2.30959286700054
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/165	42/9376	4.05887445887446	SAT1/GPX4/MAP1LC3B	2.65905070735996
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/165	180/9376	2.20983164983165	NFKBIA/SOCS3/IL1B/SRSF2/SRSF5/SRSF3/PPP1CA	2.19349138024899
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/165	110/9376	2.58292011019284	LDHA/PGK1/HIF1A/GAPDH/ENO1	2.23503027551102
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/165	46/9376	3.70592885375494	PSMA4/PSMA1/PSMB2	2.46223038702628
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/165	116/9376	2.44932079414838	TPI1/PGK1/GAPDH/ENO1/PKM	2.10214294089287
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/165	154/9376	2.21393152302243	FOS/PTGS2/ACTG1/JUN/CALM1/PPP1CA	2.03290090794099
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/165	194/9376	2.0503592627304	TPM3/ACTG1/DYNLL1/MYH9/TUBA1B/TUBA4A/TUBB4B	1.97853760726659
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/165	155/9376	2.19964809384164	ACTG1/RAC1/TUBA1B/SEC61B/TUBA4A/TUBB4B	2.01560267247678
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/165	157/9376	2.17162709901563	PTGS2/CEBPB/DUSP2/SGK1/HIF1A/RAC1	1.98139720467981
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/165	120/9376	2.36767676767677	NFKBIA/JUN/CALM1/RAC1/ARHGDIB	2.01807191723564
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/165	90/9376	2.52552188552189	FOS/NFKBIA/JUN/HIF1A	1.94625426251486
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/165	91/9376	2.4977688977689	FOS/NFKBIA/JUN/RAC1	1.92153707869547
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/165	170/9376	2.0055614973262	ACTG1/JUN/MYH9/RAC1/TUBA1B/TUBA4A	1.77080944837211
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/165	300/9376	1.70472727272727	FOS/DUSP1/JUND/JUN/DUSP2/IL1B/STMN1/RAC1/MAP3K8	1.6603845431544
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/165	173/9376	1.97078297425118	CXCL8/NFKBIA/ACTG1/SOCS3/IL1B/SLC25A5	1.72486341487753
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/165	59/9376	2.88936825885978	GPX1/GPX4/PRDX6	1.94840301179496
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/165	133/9376	2.13624971519708	GABARAPL2/KLF2/SGK1/GABARAP/PLK3	1.76631171949695
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/165	136/9376	2.08912655971479	FOS/NFKBIA/JUN/IL1B/EIF3H	1.7123243663081
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/165	99/9376	2.29592898683808	FOS/JUN/HIF1A/RAC1	1.73487920836891
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/165	30/9376	3.78828282828283	IL1B/TYMS	2.04719297367515
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/165	63/9376	2.70591630591631	PTGS2/GPX4/PTGES3	1.81826597877533
NA	NA	hsa04981	Folate transport and metabolism	2/165	31/9376	3.66608015640274	TYMS/MTHFS	1.9899337398919
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/165	142/9376	2.00085360648741	UBB/SOCS3/ANAPC11/UBE2S/UBE2D1	1.60839981579678
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/165	227/9376	1.75228941396342	CXCL8/PTGS2/NFKBIA/IL1B/CALM1/CXCR4/RAC1	1.5356253914393
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/165	103/9376	2.20676669608708	CXCL8/IL1B/PRDX1/CXCL1	1.64818522937008
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/165	32/9376	3.55151515151515	GABARAPL2/GABARAP	1.9349998917201
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/165	70/9376	2.43532467532468	JUN/HIF1A/RAC1	1.61321356849241
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/165	70/9376	2.43532467532468	ACTG1/RAC1/CD55	1.61321356849241
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/165	71/9376	2.40102432778489	LDHA/HIF1A/PKM	1.5859550762907
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/165	201/9376	1.6962460425147	CXCL8/CEBPB/NFKBIZ/DDX5/BCL2A1/REL	1.33546327975512
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/165	115/9376	1.9764953886693	FOS/EGR1/JUND/SGK1	1.41014702004599
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/165	39/9376	2.91406371406371	TYMS/MTHFS	1.60309490358665
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/165	204/9376	1.67130124777184	PLAUR/ACTG1/DDX5/HIF1A/RAC1/PPP1CA	1.29740251139547
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/165	205/9376	1.66314855875832	NFKBIA/JUN/EGR3/REL/RAC1/PKM	1.28485356260904
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/165	163/9376	1.74307492098903	FOS/CXCL8/NFKBIA/JUN/EGR3	1.28085535924501
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/165	122/9376	1.86308991554893	FOS/NFKBIA/JUN/MAP3K8	1.28423774231531
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/165	168/9376	1.69119769119769	HMGB1/HSP90AB1/IL1B/CHMP5/SLC25A5	1.20989723300054
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/165	214/9376	1.59320305862362	FOS/NFKBIA/JUN/CALM1/CXCR4/RAC1	1.17486872690725
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/165	44/9376	2.58292011019284	HMGB1/APEX1	1.40854974376016
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/165	44/9376	2.58292011019284	DYNLL1/ARHGDIB	1.40854974376016
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/165	85/9376	2.0055614973262	GUK1/APRT/TYMS	1.2464104685164
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/165	174/9376	1.63288052943225	PPP1R15A/HSP90AB1/DNAJA1/SEC61B/UBE2D1	1.1277931790966
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/165	87/9376	1.9594566353187	FOS/JUN/RAC1	1.20330221095652
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/165	47/9376	2.4180528691167	LDHA/PKM	1.30436165905246
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/165	47/9376	2.4180528691167	SOCS3/PKM	1.30436165905246
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/165	89/9376	1.91542390194076	TUBA1B/TUBA4A/TUBB4B	1.1613249257203
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/165	226/9376	1.50860820595334	FOS/NFKBIA/JUN/CALM1/RAC1/PPP1CA	1.03586045689419
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/165	49/9376	2.31935683364255	FOSB/JUN	1.23926316618797
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/165	181/9376	1.56973045370835	CEBPB/LSP1/IL1B/CALM1/PLK3	1.0358743376314
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/165	232/9376	1.46959247648903	ACTG1/MYH9/CXCR4/RAC1/FGD3/PPP1CA	0.969329060779667
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/165	93/9376	1.83304007820137	ACTG1/RAC1/PDCD10	1.08053145586746
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/165	93/9376	1.83304007820137	FOS/NFKBIA/JUN	1.08053145586746
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/165	93/9376	1.83304007820137	EGR1/JUN/CALM1	1.08053145586746
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/165	93/9376	1.83304007820137	PTGS2/NFKBIA/CKS1B	1.08053145586746
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/165	51/9376	2.22840166369578	ACTG1/SEC61B	1.17726784699062
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/165	140/9376	1.62354978354978	EGR1/KLF2/MAP1LC3B/CALM1	0.994872457160395
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/165	16/9376	3.55151515151515	MIF	1.36708159907478
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/165	144/9376	1.57845117845118	CXCL8/NFKBIA/IL1B/CXCL1	0.936212159587954
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/165	144/9376	1.57845117845118	PSMA4/PSMA1/PSMB2/SLC25A5	0.936212159587954
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/165	193/9376	1.47213063275239	CXCL8/NFKBIA/CXCR4/RAC1/CXCL1	0.886998245347987
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/165	99/9376	1.72194674012856	IL1B/CALM1/PPP1CA	0.966480726736951
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/165	100/9376	1.70472727272727	CXCL8/CXCR4/CXCL1	0.948232700175796
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/165	17/9376	3.34260249554367	MYH9	1.29384591148649
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/165	18/9376	3.15690235690236	PRDX1	1.22588416804999
NA	NA	hsa04517	IgSF CAM signaling	7/165	299/9376	1.33033343468126	ACTG1/DYNLL1/MYH9/RAC1/TUBA1B/TUBA4A/TUBB4B	0.776946614480091
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/165	60/9376	1.89414141414141	PTGS2/RAC1	0.929910850165008
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/165	203/9376	1.3996118823705	ACTG1/JUN/TLN1/RAC1/PPP1CA	0.770379885235583
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/165	107/9376	1.59320305862362	LDHA/CALM1/PKM	0.825948651687416
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/165	108/9376	1.57845117845118	SUMO2/SAP18/RAN	0.809207304760232
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/165	157/9376	1.44775139934376	CXCL8/CALM1/PPP1CA/SLC25A5	0.757214792826633
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/165	109/9376	1.56396997497915	NFKBIA/SOCS3/PPP1CA	0.79263613995098
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/165	66/9376	1.72194674012856	JUN/IL1B	0.787728405037781
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/165	67/9376	1.6962460425147	CALM1/PPP1CA	0.76546060619425
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/165	116/9376	1.46959247648903	ACTG1/CXCR4/RAC1	0.681112500098958
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/165	23/9376	2.47061923583663	IDI1	0.94506768244468
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/165	70/9376	1.62354978354978	NFKBIA/SOCS3	0.700830264222607
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/165	71/9376	1.60068288518993	FOS/SOCS3	0.679971112645932
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/165	72/9376	1.57845117845118	CXCL8/NFKBIA	0.659435505278131
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/165	122/9376	1.3973174366617	FOS/JUNB/SOCS3	0.591189908083219
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/165	73/9376	1.55682855956829	RAN/CXCR4	0.639213061639723
Organismal Systems	Immune system	hsa04611	Platelet activation	3/165	126/9376	1.35295815295815	ACTG1/TLN1/PPP1CA	0.533840899279828
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/165	76/9376	1.49537480063796	ACTG1/CALM1	0.580327901677672
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/165	233/9376	1.21940434386786	TPM3/ACTG1/TLN1/MYH9/ENO1	0.45389253640647
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/165	78/9376	1.45703185703186	ACTG1/RAC1	0.542466873892481
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/165	130/9376	1.31132867132867	FOS/NFKBIA/JUN	0.478396582955209
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/165	29/9376	1.9594566353187	CALM1	0.692568041855483
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/165	133/9376	1.28174982911825	FOS/CALM1/PPP1CA	0.437982970188476
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/165	134/9376	1.27218453188602	MYH9/CALM1/PPP1CA	0.424724268534344
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/165	31/9376	1.83304007820137	SEC61B	0.621772212779893
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/165	83/9376	1.3692588535962	PRDX1/PRDX5	0.452237127377484
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/165	83/9376	1.3692588535962	NFKBIA/IL1B	0.452237127377484
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/165	32/9376	1.77575757575758	LDHA	0.588313506271194
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/165	138/9376	1.23530961791831	CALM1/ANAPC11/PPP1CA	0.372704350367071
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/165	138/9376	1.23530961791831	SOCS3/CALM1/PPP1CA	0.372704350367071
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/165	195/9376	1.16562548562549	HMGB1/ACTG1/RAC1/SLC25A5	0.312805006788482
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/165	34/9376	1.67130124777184	NFIL3	0.524820995414026
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/165	88/9376	1.29146005509642	PLAUR/CD55	0.367649089304494
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/165	143/9376	1.19211697393516	SNRPD1/SNRPB/SNRPD3	0.309839339011324
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/165	35/9376	1.62354978354978	TPI1	0.494632545175715
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/165	89/9376	1.2769492679605	GABARAPL2/GABARAP	0.351343336524918
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/165	37/9376	1.53579033579034	MIF	0.437038572861752
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/165	37/9376	1.53579033579034	TPM3	0.437038572861752
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/165	38/9376	1.49537480063796	SGK1	0.409517997815627
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/165	154/9376	1.10696576151122	TPM3/CALM1/PPP1CA	0.179129373915049
NA	NA	hsa04518	Integrin signaling	3/165	154/9376	1.10696576151122	ACTG1/TLN1/RAC1	0.179129373915049
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/165	97/9376	1.17163386441737	FOS/CALM1	0.227411529883337
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/165	212/9376	1.07215551743854	ACTG1/TLN1/CALM1/RAC1	0.142222777162753
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/165	41/9376	1.3859571322986	ALAS2	0.33147292242573
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/165	41/9376	1.3859571322986	CXCL8	0.33147292242573
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/165	99/9376	1.14796449341904	FOS/JUN	0.198082245104995
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/165	99/9376	1.14796449341904	KRT19/KRT18	0.198082245104995
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/165	99/9376	1.14796449341904	TPM3/ACTG1	0.198082245104995
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/165	100/9376	1.13648484848485	IL1B/CD55	0.183644654351212
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/165	217/9376	1.04745147325792	FOS/JUN/HSP90AB1/PTGES3	0.094651991788413
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/165	44/9376	1.29146005509642	TAF10	0.259353572728549
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/165	44/9376	1.29146005509642	IL1B	0.259353572728549
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/165	45/9376	1.26276094276094	IL1B	0.236470621464409
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/165	105/9376	1.08236652236652	TPM3/ACTG1	0.113594239406518
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/165	46/9376	1.23530961791831	ALAS2	0.214117415095381
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/165	106/9376	1.07215551743854	NFKBIA/HSP90AB1	0.0999900602674359
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/165	166/9376	1.02694414019715	CALM1/PPP1CA/SLC25A5	0.0468773202979244
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/165	168/9376	1.01471861471861	OSM/SOCS3/MCL1	0.0257639911828924
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/165	110/9376	1.03316804407713	HSP90AB1/ANAPC11	0.0468321693650412
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/165	50/9376	1.13648484848485	SAT1	0.12950780948936
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/165	50/9376	1.13648484848485	CXCR4	0.12950780948936
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/165	52/9376	1.09277389277389	PTGS2	0.0897843284052366
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/165	52/9376	1.09277389277389	NPC2	0.0897843284052366
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/165	115/9376	0.988247694334651	PTGS2/DUSP1	-0.0169713846117038
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5/165	298/9376	0.953426886312792	CXCL8/OSM/IL1B/CXCR4/CXCL1	-0.109350943871899
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/165	238/9376	0.955029284441049	CALM1/REL/ETS2/RAC1	-0.0940517582319544
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/165	117/9376	0.971354571354571	ACTG1/MORF4L1	-0.0417292359829822
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/165	54/9376	1.05230078563412	LDHA	0.0515851576843333
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/165	362/9376	0.941838272225012	OSM/DDIT4/HSP90AB1/SGK1/MCL1/RAC1	-0.151045234204075
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/165	122/9376	0.931544957774466	ACTG1/HIF1A	-0.101857926148872
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/165	250/9376	0.909187878787879	SMAP2/CHMP5/SNX3/CXCR4	-0.194781547290397
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/165	59/9376	0.963122752953261	TYMS	-0.0380295047699881
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/165	59/9376	0.963122752953261	PTGS2	-0.0380295047699881
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/165	191/9376	0.892527367920038	FOSB/CALM1/PPP1CA	-0.200839535208651
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/165	61/9376	0.931544957774466	MT2A	-0.071788214158221
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/165	128/9376	0.887878787878788	GUK1/APRT	-0.170939755181133
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/165	62/9376	0.916520039100684	NUMB	-0.0882641176554514
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/165	68/9376	0.835650623885918	BCL2A1	-0.182040721448884
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/165	205/9376	0.831574279379158	NFKBIA/JUN/RAC1	-0.326325654058389
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/165	69/9376	0.823539745278876	RAC1	-0.196897775384268
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/165	69/9376	0.823539745278876	CALM1	-0.196897775384268
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/165	70/9376	0.811774891774892	PTGS2	-0.211553040047202
NA	NA	hsa04519	Cadherin signaling	6/165	404/9376	0.843924392439244	NFKBIA/ACTG1/KRT19/KRT18/RAC1/PPP1CA	-0.429195641911767
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/165	75/9376	0.757656565656566	GPX1	-0.282014401509473
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/165	148/9376	0.767895167895168	FOS/JUN	-0.38092148251034
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/165	76/9376	0.747687400318979	PLIN2	-0.295582337557655
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/165	76/9376	0.747687400318979	CALM1	-0.295582337557655
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/165	77/9376	0.737977174340811	RAC1	-0.308987267444061
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/165	77/9376	0.737977174340811	NFKBIA	-0.308987267444061
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/165	78/9376	0.728515928515929	TPI1	-0.322233807783123
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/165	156/9376	0.728515928515929	NFKBIA/SOCS3	-0.457630974274106
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/165	157/9376	0.723875699671878	ACTG1/PPP1CA	-0.466967619026546
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/165	82/9376	0.692978566149298	HSP90AB1	-0.373721864498869
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/165	158/9376	0.719294207901803	DDIT4/SGK1	-0.476250872939221
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/165	83/9376	0.684629426798102	UBE2D1	-0.386239302579267
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/165	86/9376	0.660747004933051	JUN	-0.422998939211692
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/165	86/9376	0.660747004933051	ACTG1	-0.422998939211692
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/165	93/9376	0.611013359400456	CALM1	-0.504552316363364
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/165	178/9376	0.638474633980252	JUN/RAC1	-0.651742875167294
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/165	323/9376	0.70370578853551	PTGS2/DDIT4/MCL1/STMN1	-0.725274464598646
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/165	98/9376	0.579839208410637	CALM1	-0.559597280851509
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/165	98/9376	0.579839208410637	RAC1	-0.559597280851509
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/165	98/9376	0.579839208410637	CALM1	-0.559597280851509
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/165	254/9376	0.671152469577666	CALM1/CXCR4/SLC25A5	-0.711116291373573
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/165	101/9376	0.562616261626163	CALM1	-0.591480701303768
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/165	102/9376	0.557100415923945	RAC1	-0.601930059230084
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/165	184/9376	0.617654808959157	CXCR4/RAC1	-0.70102540183852
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/165	110/9376	0.516584022038567	SKIL	-0.682567199350286
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/165	112/9376	0.507359307359307	NFKBIA	-0.701963029261431
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/165	115/9376	0.494123847167325	FOS	-0.730530586940553
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/165	122/9376	0.465772478887233	RAB2A	-0.794905760380962
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/165	125/9376	0.454593939393939	RAC1	-0.821589432729852
NA	NA	hsa04382	Cornified envelope formation	2/165	217/9376	0.523725736628962	KRT19/KRT18	-0.95002967390689
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/165	133/9376	0.427249943039417	RAC1	-0.890345779119999
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/165	144/9376	0.394612794612795	SKIL	-0.979807603573423
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/165	149/9376	0.381370754525117	CXCL8	-1.01874980899695
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/165	154/9376	0.368988587170405	ALAS2	-1.05671831543558
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/165	158/9376	0.359647103950901	ANAPC11	-1.08643510150961
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/165	170/9376	0.334260249554367	ACTG1	-1.17237806278454
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/165	183/9376	0.310514985924822	RAN	-1.26065417141652
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/165	333/9376	0.341286741286741	PTGS2/PKM	-1.63808515877587
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/165	250/9376	0.22729696969697	NPC2	-1.65735905988631
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/165	449/9376	0.126557332793413	CALM1	-2.53851085840274