category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	68/622	268/9376	3.82473484666699	CALM1/UBE2L6/UBC/PSMC5/COX5A/TXN/TUBB4B/UQCRH/DUSP1/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PSMB1/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/VDAC2/CALM3/PSMB3/SDHD/PSMA7/SLC25A6/COX4I1/NDUFAB1/PSMA1/UQCRFS1/NDUFA13/NDUFB10/COX7B/PSMA5/PSMB7/NDUFA12/SOD1/TXN2/PARK7/PSMC1/PSMB6/BAX/UBB/PSMB4/UBE2L3/NDUFS5/PSMD8/NDUFC2/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/PSMA3/MT-ATP6/PSMC2/GNAI3/NDUFS3/TUBB6/NDUFA7/NDUFA8/ADRM1/PINK1/UQCRC2/UQCR10/NDUFB5	12.5057900390087
Genetic Information Processing	Translation	hsa03010	Ribosome	59/622	222/9376	4.00614118942093	RPS10/RPL36A/RPS4Y1/RPS26/RPL36AL/RPL3/RPS27L/MRPS18C/RPS3/MRPS18B/RPS9/RPS20/RPL7/RPL7A/RPL17/RPS2/MRPL41/RPL27/RPS5/RPS25/RPL8/RPL23A/RPS18/RPL14/RPL27A/MRPL34/RPL6/RPL5/RPL22L1/RPS3A/MRPS15/MRPL51/RPL24/RPSA/MRPL27/RPL13/MRPL14/RPS4X/RPL31/MRPL18/RPL26/RPS6/MRPL54/RPS16/RPL4/RPL9/MRPL47/RPL10/RPL15/RPL26L1/RPL23/MRPL21/RSL24D1/MRPL22/RPL11/MRPL9/MRPL43/RPL29/RPL13A	12.0825323561977
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	60/622	238/9376	3.80015671863601	ISG15/OAS2/JUN/NFKBIA/MX2/RPS10/MX1/RPL36A/RPS4Y1/CXCL8/OAS1/RPS26/IFIH1/EIF2AK2/RPL36AL/RPL3/C5AR1/OAS3/RPS27L/RPS3/RPS9/STAT1/RPS20/RPL7/RPL7A/RPL17/RPS2/RPL27/C1QC/RPS5/RPS25/MYD88/RPL8/RPL23A/RPS18/RPL14/RPL27A/RPL6/RPL5/RPL22L1/RPS3A/RPL24/RPSA/RPL13/RPS4X/RPL31/RPL26/RPS6/RPS16/RPL4/RPL9/CFD/RPL10/RPL15/RPL26L1/RPL23/RSL24D1/RPL11/RPL29/RPL13A	11.6633363370199
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	69/622	308/9376	3.376957447697	PSMC5/COX5A/TUBB4B/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PSMB1/COX7A2L/GPX1/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/VDAC2/GPX3/PSMB3/SLC1A3/SDHD/POLR2E/POLR2K/PSMA7/SLC25A6/COX4I1/CLTB/NDUFAB1/POLR2F/AP2S1/PSMA1/UQCRFS1/NDUFA13/NDUFB10/COX7B/PSMA5/PSMB7/NDUFA12/SOD1/PSMC1/PSMB6/BAX/PSMB4/NDUFS5/SOD2/PSMD8/NDUFC2/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/POLR2H/PSMA3/MT-ATP6/PSMC2/NDUFS3/TUBB6/GNAQ/CREB3/NDUFA7/NDUFA8/ADRM1/UQCRC2/UQCR10/NDUFB5/WIPI2	11.306249603816
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	63/622	275/9376	3.45330605086232	CSNK2B/PSMC5/COX5A/RAC1/TUBB4B/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PSMB1/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/VDAC2/PSMB3/SDHD/PSMA7/SLC25A6/COX4I1/NDUFAB1/PSMA1/UQCRFS1/NDUFA13/NCF1/NDUFB10/COX7B/C1QC/PSMA5/PSMB7/NDUFA12/SOD1/PSMC1/PSMB6/BAX/PSMB4/NDUFS5/PSMD8/NCF2/NDUFC2/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/PSMA3/CAV1/MT-ATP6/PSMC2/NDUFS3/TUBB6/CREB3/NDUFA7/NDUFA8/ADRM1/UQCRC2/UQCR10/NDUFB5	11.0065466624336
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	70/622	368/9376	2.86732839368097	HNRNPA1/PSMC5/COX5A/RAC1/TUBB4B/MAP1LC3B/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PFN1/PSMB1/COX7A2L/GPX1/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/GPX3/PSMB3/SDHD/CHCHD10/PSMA7/COX4I1/RAB8A/NDUFAB1/ANXA7/PSMA1/UQCRFS1/NDUFA13/NDUFB10/COX7B/PSMA5/PSMB7/SQSTM1/NDUFA12/SOD1/PSMC1/PSMB6/BAX/PSMB4/NDUFS5/PSMD8/ANG/NDUFC2/RAB1A/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/SRSF3/PSMA3/MT-ATP6/PSMC2/NDUFS3/TUBB6/NDUFA7/NDUFA8/ADRM1/ANXA11/PINK1/UQCRC2/UQCR10/NDUFB5/WIPI2	9.74109953295656
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	22/622	46/9376	7.20928281839787	PSME2/PSMB9/PSMC5/PSMB8/POMP/PSMB2/PSMB1/PSMA2/PSMB3/PSMA7/PSMB10/PSMA1/PSMA5/PSMB7/PSMC1/PSMB6/PSMB4/PSMD8/PSMA3/PSME1/PSMC2/ADRM1	11.2527091763298
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	38/622	138/9376	4.1507991984715	ATP6V1F/COX5A/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/SDHD/COX4I1/NDUFAB1/ATP6V1G1/UQCRFS1/NDUFA13/NDUFB10/COX7B/NDUFA12/NDUFS5/ATP6V0E1/NDUFC2/NDUFS7/NDUFA2/NDUFB2/MT-ATP6/NDUFS3/PPA1/COX17/NDUFA7/NDUFA8/UQCRC2/UQCR10/ATP6V1B2/NDUFB5	9.93914096055946
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	48/622	227/9376	3.18744422567531	JUN/NFKBIA/COX5A/RAC1/GSTO1/VEGFA/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/GRB2/COX7A2L/HMOX1/NDUFS6/NDUFS4/SDHB/NDUFV2/VDAC2/SDHD/SLC25A6/COX4I1/NDUFAB1/UQCRFS1/NDUFA13/NCF1/NDUFB10/COX7B/NDUFA12/SOD1/NDUFS5/SOD2/NCF2/NDUFC2/AHR/VDAC1/NDUFS7/NDUFA2/NDUFB2/AKR1A1/MT-ATP6/NDUFS3/PTEN/NDUFA7/NDUFA8/UQCRC2/UQCR10/NDUFB5	8.8928437690358
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	75/622	480/9376	2.35530546623794	CALM1/CSNK2B/UBE2L6/UBC/PSMC5/COX5A/CAPN2/RAC1/TUBB4B/MAP1LC3B/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PSMB1/COX7A2L/GPX1/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/VDAC2/GPX3/CALM3/PSMB3/SDHD/PSMA7/SLC25A6/COX4I1/RAB8A/NDUFAB1/PSMA1/UQCRFS1/NDUFA13/NDUFB10/COX7B/PSMA5/PSMB7/SQSTM1/NDUFA12/SOD1/PARK7/PSMC1/PSMB6/BAX/UBB/PSMB4/UBE2L3/NDUFS5/PSMD8/NDUFC2/RAB1A/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/PSMA3/MT-ATP6/PSMC2/NDUFS3/TUBB6/GNAQ/NDUFA7/NDUFA8/ADRM1/PINK1/UQCRC2/UQCR10/NDUFB5/WIPI2	8.12527335938574
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	38/622	157/9376	3.64847318082209	JUN/CXCL8/COX5A/RAC1/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/SDHD/SOCS3/COX4I1/NDUFAB1/UQCRFS1/NDUFA13/NDUFB10/COX7B/NDUFA12/IRS2/BAX/NDUFS5/NDUFC2/NDUFS7/NDUFA2/NDUFB2/MLXIP/NDUFS3/NDUFA7/NDUFA8/UQCRC2/UQCR10/NDUFB5	8.9203328058003
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	64/622	388/9376	2.48642556435841	GAPDH/CALM1/CSNK2B/PSMC5/COX5A/CAPN2/EIF2AK2/TUBB4B/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/CYCS/PSMB2/PSMB1/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/PSMA2/VDAC2/CALM3/PSMB3/SDHD/PSMA7/SLC25A6/COX4I1/NDUFAB1/PSMA1/UQCRFS1/NDUFA13/NDUFB10/COX7B/PSMA5/PSMB7/NDUFA12/IRS2/PSMC1/PSMB6/PSMB4/NDUFS5/PSMD8/NDUFC2/TUBA1C/VDAC1/NDUFS7/NDUFA2/NDUFB2/PSMA3/MT-ATP6/PSMC2/NDUFS3/TUBB6/GNAQ/PSENEN/NDUFA7/NDUFA8/ADRM1/UQCRC2/UQCR10/NDUFB5/WIPI2	7.97085770615073
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	40/622	180/9376	3.34976777420507	HLA-A/OAS2/NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/B2M/HLA-DRA/HLA-DRB1/OAS1/PILRA/IFIH1/EIF2AK2/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/OAS3/CYCS/STAT1/IRF7/HLA-DMA/HLA-B/SOCS3/EIF4EBP1/CD74/MYD88/BST2/BAX/HLA-DRB5/TNFRSF14/SRSF9/SRSF3/IFNGR2/TAP1/CFP/RHEB/PPP1CB/HLA-E	8.48475436719013
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	42/622	205/9376	3.08832248451102	ISG15/VIM/HLA-A/OAS2/JUN/NFKBIA/HLA-DQA1/SAP30/HLA-DPB1/HLA-DPA1/B2M/HLA-DRA/HLA-DRB1/PSMC5/OAS1/RAC1/EIF2AK2/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/OAS3/CYCS/STAT1/IRF7/HLA-DMA/HLA-B/MYD88/PSMC1/BAX/TNFAIP3/CCND3/PSMD8/HLA-DRB5/TAP1/CIR1/PSMC2/CD58/HLA-E/ADRM1/RUNX3	8.05830512302399
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/622	205/9376	3.08832248451102	GAPDH/COX5A/RAC1/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/VDAC2/SDHD/SLC25A6/COX4I1/NDUFAB1/UQCRFS1/NDUFA13/NCF1/NDUFB10/COX7B/NDUFA12/NDUFS5/NCF2/NDUFC2/VDAC1/NDUFS7/NDUFA2/NDUFB2/MPC2/MT-ATP6/NDUFS3/PPP1CB/PTEN/NDUFA7/NDUFA8/CTSD/UQCRC2/UQCR10/NDUFB5	8.05830512302399
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/622	155/9376	3.40379628669225	FCGR2B/HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/ATP6V1F/RAC1/TUBB4B/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/SEC61G/ATP6V1G1/CLEC7A/SEC61B/NCF1/HLA-DRB5/NCF2/ATP6V0E1/RILP/VAMP3/TUBA1C/ITGAM/TAP1/TUBB6/MSR1/HLA-E/RAB7A/ATP6V1B2	8.04362948550614
Human Diseases	Immune disease	hsa05330	Allograft rejection	16/622	39/9376	6.1841866600709	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/HLA-DRB5/CD86/HLA-E	8.64742519311003
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/622	95/9376	3.96683025892706	JUN/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/CXCL8/ATP6V1F/TNFSF13B/HLA-DQB1/VEGFA/HLA-DQA2/HLA-DOA/HLA-DMA/ACP5/ATP6V1G1/CXCL3/HLA-DRB5/ATP6V0E1/IL18/CCL3L3/CD86/CXCL2/LTB/ATP6V1B2	7.74701997004466
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/622	82/9376	4.22806054427104	HLA-A/PSME2/HLA-DQA1/HLA-DPB1/HLA-DPA1/B2M/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/CD74/HLA-DRB5/HSP90AB1/TAP1/PSME1/RFXANK/HLA-E/IFI30	7.82572933571436
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	42/622	235/9376	2.69406855031812	COX5A/UQCRH/NDUFB7/NDUFB8/COX5B/NDUFA6/GRB2/COX7A2L/NDUFS6/NDUFS4/SDHB/NDUFV2/ACSL1/SDHD/COX4I1/COA6/NDUFAB1/UQCRFS1/NDUFA13/COX14/NDUFB10/COX7B/NDUFA12/NDUFS5/COA3/NDUFC2/NDUFS7/NDUFA2/NDUFB2/RPS6/NDUFAF3/COA4/MT-ATP6/NDUFS3/RHEB/COX17/CREB3/NDUFA7/NDUFA8/UQCRC2/UQCR10/NDUFB5	7.01044547906512
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/622	44/9376	5.48143817597194	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/HLA-DRB5/CD86/HLA-E	7.94207423363112
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/622	45/9376	5.35962843872812	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/HLA-DRB5/CD86/HLA-E	7.81392428116762
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/622	173/9376	2.87537869635522	OAS2/NFKBIA/MX2/HLA-DQA1/MX1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/CXCL8/OAS1/IFIH1/EIF2AK2/HLA-DQB1/HLA-DQA2/HLA-DOA/PYCARD/OAS3/CYCS/RSAD2/STAT1/IRF7/HLA-DMA/SOCS3/SLC25A6/MYD88/RAB11A/BAX/CCND3/HLA-DRB5/VDAC1/IL18/IFNGR2	6.63628269851379
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/622	70/9376	4.09150206706477	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/RAC1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/CYCS/HLA-DMA/HLA-B/HLA-DRB5/CAV1/CD86/HLA-E	6.92013547244273
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/622	248/9376	2.43128306192304	GAPDH/DYNLL1/S100A10/JUN/NFKBIA/CXCL8/RAC1/TXN/MYL12A/TUBB4B/DYNLRB1/ANXA2/MYL12B/ARPC4/PYCARD/DYNLT1/CYCS/RPS3/PFN1/ARPC3/BRK1/RHOA/TXN2/MYD88/BAX/SKP1/RHOB/ABI1/RALA/HSP90AB1/RILP/FLNA/TUBA1C/IL18/TUBB6/STX10/ARPC1A/KPNA3/RAB7A/DYNLT3	6.08893188691348
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/622	54/9376	4.46635703227343	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/HLA-B/HLA-DRB5/CD86/HLA-E	6.80915441015987
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/622	78/9376	3.6718608294171	JUN/NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/STAT1/HLA-DMA/NCF1/MYD88/EEF1A1/HLA-DRB5/NCF2/ITGAM/IFNGR2	6.31602620045541
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/622	50/9376	4.22070739549839	CXCR4/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/TNFSF13B/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-DMA/HLA-DRB5/CD86/ITGB7	6.08647898059651
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/622	224/9376	2.28801102434543	HLA-A/JUN/NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/B2M/HLA-DRA/HLA-DRB1/HLA-F/HLA-DQB1/TSPO/HLA-DQA2/HLA-DOA/HLA-C/HLA-DMA/ANAPC13/VDAC2/HLA-B/SLC25A6/ANAPC11/BAX/CCND3/MAP3K3/HLA-DRB5/VDAC1/RAN/ANAPC16/KAT5/SPI1/PTEN/HLA-E/CREB3/RANBP1	5.2007160547884
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/622	243/9376	2.17114577957736	HNRNPA1/SNRPB/SNU13/SF3B6/SNRPG/SNRPE/LSM7/SNRPD2/RBM8A/CWC15/SNRPD3/SLU7/PCBP1/SNRPC/MAGOH/LSM6/LSM3/ZMAT2/SRSF9/BCAS2/SF3B2/SRSF3/SF3B5/PRPF6/SNRPD1/PQBP1/TXNL4A/THOC7/LSM2/SNRPB2/BUD31/PUF60/HNRNPM/EIF4A3/SYF2	4.93043145095192
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/622	181/9376	2.33188253894939	FCGR2B/CALM1/LSP1/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/CEBPB/HLA-DQB1/HLA-DQA2/HLA-DOA/CYCS/STAT1/HLA-DMA/CALM3/CLEC7A/CD74/RHOA/MYD88/BAX/HLA-DRB5/ITGAM/IL18/IFNGR2/RFXANK/RAB7A/CTSD	4.82288498824613
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/622	99/9376	2.89298125954075	FCGR2B/FPR3/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/C5AR1/HLA-DMA/KRT19/PTAFR/C1QC/HLA-DRB5/ITGAM/CFD/SELPLG	5.04705099565723
Human Diseases	Immune disease	hsa05310	Asthma	10/622	32/9376	4.71061093247588	HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-DMA/HLA-DRB5	5.60443134635549
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/622	144/9376	2.4076455877099	PSMC5/CYCS/PSMB2/PSMB1/PSMA2/VDAC2/PSMB3/PSMA7/SLC25A6/PSMA1/PSMA5/PSMB7/PSMC1/PSMB6/PSMB4/PSMD8/VDAC1/PSMA3/PSMC2/KAT5/GNAQ/ADRM1/WIPI2	4.5373703723423
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/622	66/9376	3.1975056026503	JUN/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/STAT1/HLA-DMA/HLA-DRB5/IL18/IFNGR2	4.77534417047457
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/622	67/9376	3.14978163843164	LDHA/ALDOA/GAPDH/TPI1/PKM/ENO1/PGK1/FBP1/HK2/PGAM1/GPI/ALDH2/ADH5/AKR1A1	4.7071473647944
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	23/622	149/9376	2.32685211161225	GNG5/NDUFB7/NDUFB8/NDUFA6/NDUFS6/NDUFS4/NDUFV2/NDUFAB1/NDUFA13/NDUFB10/NDUFA12/NDUFS5/NDUFC2/NDUFS7/NDUFA2/NDUFB2/GABRB2/GNAI3/NDUFS3/GNAQ/NDUFA7/NDUFA8/NDUFB5	4.35174013254034
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/622	160/9376	2.26109324758842	HLA-A/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/ALCAM/HLA-F/VCAN/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-C/JAML/HLA-DMA/HLA-B/CD99/HLA-DRB5/ITGAM/CD86/CD58/HLA-E/ITGB7/SELPLG	4.28858002071386
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/622	116/9376	2.46900986805633	ALDOA/GAPDH/TPI1/PKM/ENO1/PGK1/FBP1/ESD/TALDO1/ECHS1/SDHB/HK2/SDHD/PGAM1/GPI/TKT/ADH5/SUCLG1/PRPS1	4.24351531448545
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/622	56/9376	3.23013321084061	NFKBIA/CXCL8/PYCARD/CYCS/BNIP3/CXCL3/MYD88/EEF1A1/RAB1A/ITGAM/IL18/CXCL2	4.46163894029598
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	18/622	109/9376	2.48927696982212	JUN/NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/STAT1/HLA-DMA/IL1RAP/HLA-DRB5/HSP90AB1/AHR/IL27RA/IFNGR2	4.16866216362429
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/622	253/9376	1.90658719164241	JUN/NFKBIA/UBC/CXCL8/CAPN2/RAC1/MYL12A/MYL12B/MAP1LC3B/ARPC4/PYCARD/CYCS/PFN1/ARPC3/HK2/BNIP3/UBE2D2/RBX1/CAST/RHOA/SQSTM1/MYD88/HCLS1/BAX/SKP1/UBB/CAPNS1/VDAC1/IL18/RRAGD/ARPC1A/WIPI2	3.89653482054217
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/622	169/9376	2.14067999771685	DDIT4/UBC/MAP1LC3B/GABARAPL2/ATG3/BNIP3/RAB8A/TAX1BP1/IGBP1/SQSTM1/IRS2/UBB/HMGB1/RAB1A/VAMP8/RHEB/RRAGD/PPP2CB/PTEN/WDR45B/RAB7A/CTSD/DAPK1/WIPI2	3.98864758586466
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/622	142/9376	2.22924686381957	FCGR2B/JUN/NFKBIA/TREM2/JUND/RAC1/GRB2/STAT1/ACP5/SOCS3/LILRA5/NCF1/JUNB/SQSTM1/FOSB/LILRB2/NCF2/LILRB4/IFNGR2/SPI1/OSCAR	3.93428580062852
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/622	196/9376	1.99960627337752	CALM1/HLA-A/JUN/NFKBIA/UBC/CXCL8/GNG5/RAC1/EIF2AK2/HLA-F/VEGFA/MAP1LC3B/HLA-C/CLEC2B/CYCS/STAT1/IRF7/ATG3/HLA-B/CALM3/CXCL3/BAX/UBB/CD86/CXCL2/HLA-E	3.76975588196262
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/622	187/9376	2.01523462351909	OAS2/JUN/NFKBIA/CXCL8/OAS1/TXN/TXNIP/MAP1LC3B/CARD16/PYCARD/OAS3/GABARAPL2/STAT1/IRF7/VDAC2/RHOA/TXN2/CXCL3/MYD88/TNFAIP3/HSP90AB1/VDAC1/IL18/CXCL2/GBP1	3.73792563889153
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/622	136/9376	2.216758085871	FCGR2B/OAS2/JUN/NFKBIA/CSNK2B/MX2/MX1/EIF3H/OAS1/IFIH1/EIF2AK2/OAS3/CYCS/STAT1/IRF7/MSN/MYD88/BAX/TNFAIP3/CCND3	3.80991484554882
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/622	142/9376	2.12309225125674	CALM1/JUN/SUMO2/RAC1/TXN/GSTO1/VEGFA/DUSP1/HMOX1/KLF2/SUMO1/CALM3/GSTP1/NCF1/RHOA/SQSTM1/TXN2/NCF2/HSP90AB1/CAV1	3.59453094977662
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/622	112/9376	2.28801102434543	NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/ALOX5/CYCS/STAT1/HLA-DMA/MYD88/HLA-DRB5/IFNGR2/GNAI3	3.65516408530574
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/622	93/9376	2.43128306192304	JUN/NFKBIA/HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQB1/HLA-DQA2/HLA-DOA/STAT1/HLA-DMA/HLA-DRB5/IFNGR2/RUNX3	3.69743365736762
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/622	105/9376	2.29698361659776	JUN/CSNK2B/UBC/MAP1LC3B/CITED2/BNIP3L/GABARAPL2/BNIP3/TOMM20/TAX1BP1/SQSTM1/UBB/TOMM7/RAB7A/PINK1/SAMM50	3.56240595865541
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/622	78/9376	2.5123258306538	CALM1/JUN/CXCL8/PYCARD/CFL1/CALM3/C1QC/RHOA/MYD88/IRF8/SERPING1/ITGAM/GNAI3	3.57499517372646
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/622	110/9376	2.19257527038878	LDHA/ALDOA/GAPDH/ENO1/TIMP1/PGK1/VEGFA/HMOX1/EGLN3/EIF4E2/HK2/EIF4EBP1/RBX1/RPS6/IFNGR2/EGLN1	3.35361770278933
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	24/622	200/9376	1.80887459807074	GAPDH/JUN/NFKBIA/CXCL8/RAC1/TUBB4B/NCL/MYO1G/ARPC4/PYCARD/CYCS/RPS3/ARPC3/BRK1/RHOA/MYD88/HCLS1/BAX/ABI1/RAB1A/TUBA1C/IL18/TUBB6/ARPC1A	3.08210231602665
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/622	100/9376	2.1103536977492	HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/HLA-DRB1/CD9/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-DMA/HLA-DRB5/ANPEP/ITGAM/IL7R	2.97549025764911
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/622	71/9376	2.33540147638241	JUN/NFKBIA/CXCL8/ATP6V1F/RAC1/ATP6V1G1/CXCL3/ATP6V0E1/CXCL2/CSK/ATP6V1B2	3.01065088097253
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	20/622	168/9376	1.794518450467	FTH1/CAPN2/EIF2AK2/FTL/CHMP2A/PYCARD/STAT1/VDAC2/SLC25A6/GLUL/SQSTM1/BAX/TNFAIP3/PPIA/HMGB1/CHMP5/HSP90AB1/VDAC1/IFNGR2/CHMP4B	2.76983266015865
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/622	157/9376	1.82423659041104	CALM1/HLA-A/ZFP36L2/CXCL8/CAPN2/HLA-F/HLA-C/VDAC2/HLA-B/CALM3/SLC25A6/EIF4EBP1/SQSTM1/CCND3/VDAC1/RHEB/PPP1CB/PTEN/HLA-E	2.77611446112602
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/622	214/9376	1.69053700754275	CALM1/HLA-A/CXCR4/JUN/NFKBIA/B2M/GNG5/RAC1/HLA-F/HLA-C/CFL1/CYCS/HLA-B/CALM3/RBX1/MYD88/BST2/BAX/SKP1/TAP1/GNAI3/GNAQ/RNF7/HLA-E	2.72380655554659
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/622	227/9376	1.66012720087256	CALM1/HLA-A/CXCR4/NFKBIA/B2M/CXCL8/GNG5/RAC1/HLA-F/VEGFA/HLA-C/CYCS/GRB2/HLA-B/CALM3/EIF4EBP1/RHOA/BAX/TAP1/CCL3L3/GNAI3/RHEB/GNAQ/HLA-E/CREB3	2.68368354088583
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/622	94/9376	2.08469590203188	JUN/NFKBIA/JUND/CXCL8/CEBPB/CXCL3/FOSB/TNFAIP3/S100A9/HSP90AB1/S100A8/CXCL2/ELAVL1	2.81727151085854
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/622	75/9376	2.21084673097535	ALDOA/GAPDH/TPI1/PKM/ENO1/PGK1/TALDO1/PGAM1/TKT/GLUL/PRPS1	2.8062899601507
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/622	142/9376	1.80462841356823	UBE2L6/UBC/UBE2B/ANAPC13/SOCS3/UBE2D2/RBX1/UBE2I/ANAPC11/SKP1/UBB/UBE2L3/UBE2F/UBE2M/ANAPC16/RNF7/UBE2E1	2.5752663972209
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/622	31/9376	2.91753967430764	ALDOA/FBP1/TALDO1/GPI/TKT/PRPS1	2.85044792870969
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/622	250/9376	1.56769131832797	HLA-A/CXCR4/HLA-F/CHMP2A/HLA-C/ARPC4/ARPC3/HLA-B/CLTB/RAB8A/AP2S1/RHOA/RAB11A/SMAP2/CHMP5/VPS29/CAV1/RUFY1/VTA1/ARPC1A/HLA-E/SNX2/CHMP4B/RAB7A/SNF8/SNX3	2.42504378395966
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/622	156/9376	1.73930249814494	IFIT1/OAS2/NFKBIA/MX2/MX1/YWHAH/OAS1/EIF2AK2/OAS3/CYCS/GRB2/RSAD2/STAT1/IRF7/SOCS3/EIF3E/BAX/PPP2CB	2.48197025123324
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/622	216/9376	1.60509705847326	CALM1/JUN/NFKBIA/CXCL8/RAC1/PYCARD/CYCS/ERO1A/IRF7/CALM3/NCF1/RAP1A/RHOA/CXCL3/MYD88/BAX/SOD2/NCF2/HSP90AB1/IL18/CCL3L3/CXCL2/RAP1B	2.3981797961337
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	22/622	205/9376	1.61769272998196	HLA-A/PKM/JUN/NFKBIA/YWHAH/RAC1/EIF2AK2/HLA-F/HLA-C/GRB2/MRPS18B/IRF7/HLA-B/GSN/RHOA/PSMC1/BAX/CCND3/HDAC5/HLA-E/CREB3/RANBP1	2.38351908164884
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/622	51/9376	2.3645419582624	ATP6V1F/ERO1A/SEC61G/ATP6V1G1/SEC61B/KDELR2/ATP6V0E1/ATP6V1B2	2.60450455638788
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/622	42/9376	2.5123258306538	FTH1/MAP1LC3B/FTL/HMOX1/VDAC2/ACSL1/PCBP1	2.61826545854613
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/622	83/9376	1.99775307015845	NFKBIA/PYCARD/IRF7/POLR1D/POLR2E/POLR2K/POLR2F/PCBP1/POLR3GL/IL18/POLR2H	2.43367011919306
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/622	116/9376	1.81927042909413	CXCR4/RAC1/MYL12A/MYL12B/MSN/CD99/NCF1/RAP1A/RHOA/NCF2/ITGAM/RAP1B/GNAI3/CTNNA1	2.36661896435452
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/622	73/9376	2.0649253402634	CXCR4/MX2/MX1/BST2/PPIA/RAN/MAP1S/SUPT4H1/MDFIC/CHMP4B	2.43470664091967
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/622	34/9376	2.66010970304521	POLR1D/POLR2E/POLR2K/POLR2F/POLR3GL/POLR2H	2.58484124215465
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	16/622	143/9376	1.68659636183752	HLA-DQA1/HLA-DPB1/HLA-DPA1/HLA-DRA/SSB/HLA-DRB1/SNRPB/HLA-DQB1/HLA-DQA2/HLA-DOA/HLA-DMA/SNRPD3/C1QC/HLA-DRB5/CD86/SNRPD1	2.20534052564702
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/622	193/9376	1.56206787398164	CXCR4/NFKBIA/CXCL8/GNG5/RAC1/CXCL16/GRB2/STAT1/NCF1/RAP1A/RHOA/CXCL3/CCL3L3/CXCL2/RAP1B/GNAI3/PPBP/WAS/GNAQ/CCL13	2.10306494725177
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/622	170/9376	1.59606582182712	JUN/RAC1/MYL12A/MYL12B/ARPC4/YBX3/ARPC3/MSN/MYL6/RAB13/RAB8A/RAP1A/RHOA/HCLS1/TUBA1C/WAS/ARPC1A/PPP2CB	2.09055094344665
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/622	70/9376	1.93807992650436	JUN/RAC1/VEGFA/GRB2/EGLN3/RBX1/RAP1A/RAP1B/EGLN1	2.09983368426236
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/622	105/9376	1.72273771244832	NFKBIA/CSNK2B/CXCL8/TNFSF13B/UBE2I/CXCL3/MYD88/TNFAIP3/CXCL2/CCL13/LTB/PLAU	1.98513311997323
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/622	203/9376	1.48511871762787	JUN/CAPN2/RAC1/MYL12A/MYL12B/VEGFA/GRB2/PARVB/RAP1A/RHOA/CCND3/VEGFB/FLNA/CAV1/RAP1B/PPP1CB/PTEN/EMP1/ZYX/ITGB7	1.86259277161774
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/622	31/9376	2.43128306192304	SEC61G/SRP9/SEC61B/SRP14/SPCS2	2.12762108337021
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/622	32/9376	2.35530546623794	GABARAPL2/ATG3/IGBP1/PPP2CB/WIPI2	2.04702583404579
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/622	43/9376	2.10334255589621	ECHS1/ACSL1/ALDH2/ADH5/ACAA2/ECI1	1.93290951308274
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/622	33/9376	2.28393257332164	VAMP5/VAMP3/VAMP8/STX8/STX3	1.96939836011717
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/622	78/9376	1.73930249814494	RAC1/ARPC4/ARPC3/CLTB/RHOA/HCLS1/CAV1/ARPC1A/CTNNA1	1.74764115590717
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/622	138/9376	1.52924180996319	CALM1/FBP1/GRB2/EIF4E2/HK2/CALM3/SOCS3/EIF4EBP1/IRS2/FLOT1/RPS6/RHEB/PPP1CB/PPP1R3B	1.66948403249484
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/622	35/9376	2.1534221405604	ALDOA/TPI1/FBP1/AKR1B1/HK2	1.82222994509127
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/622	93/9376	1.62085537461536	CSNK2B/RAC1/MYL12A/MYL12B/RAP1A/RHOA/PDCD10/RAP1B/WAS/CTNNA1	1.60385574281591
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/622	59/9376	1.78843533707559	GSTO1/PRDX6/GPX1/GPX3/GSTP1/SMS/ANPEP	1.61931596732963
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	15/622	158/9376	1.43107167568888	DDIT4/ATP6V1F/LAMTOR5/SGK1/GRB2/EIF4E2/EIF4EBP1/ATP6V1G1/LAMTOR1/RHOA/RPS6/RHEB/RRAGD/PTEN/ATP6V1B2	1.4565897137929
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/622	108/9376	1.53531022984399	SUMO2/SAP18/RBM8A/SUMO1/UBE2I/EEF1A1/MAGOH/RAN/THOC7/KPNA3/EIF4A3	1.49142688465726
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	22/622	250/9376	1.32650803858521	CTSH/SLC11A1/ATP6V1F/LAMTOR5/BLOC1S1/ACP5/CLTB/AP2S1/ATP6V1G1/LAMTOR1/LITAF/ATP6V0E1/VPS29/BLOC1S2/VAMP8/RRAGD/OSBPL1A/RAB7A/CTSD/IDS/CTSA/ATP6V1B2	1.39476554215415
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/622	28/9376	2.1534221405604	ATP6V1F/ATP6V1G1/ATP6V0E1/ATP6V1B2	1.62924166129889
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/622	18/9376	2.5123258306538	PRDX1/TCN2/MMADHC	1.71185770350565
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/622	333/9376	1.26747969834787	ISG15/HLA-A/PKM/MX2/MX1/ATP6V1F/EIF2AK2/HLA-F/VEGFA/HLA-C/GRB2/STAT1/HLA-B/EIF4EBP1/ATP6V1G1/PSMC1/BAX/CCND3/ATP6V0E1/RHEB/PPP2CB/PTEN/HLA-E/OASL/CREB3/ITGB7/ATP6V1B2/MFNG	1.32475093738002
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/622	87/9376	1.55937465350926	COX5A/UQCRH/COX5B/COX7A2L/COX4I1/UQCRFS1/COX7B/UQCRC2/UQCR10	1.39719006205699
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/622	63/9376	1.67488388710254	POLR2E/POLR2K/POLR2F/RBX1/POLR2H/RPA2/GTF2H5	1.43262357024059
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/622	138/9376	1.42001025210867	JUN/NFKBIA/CXCL8/RAC1/ARPC4/PYCARD/ARPC3/RHOA/MYD88/IL18/WAS/GNAQ/ARPC1A	1.32491499382548
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/622	10/9376	3.01479099678457	PAPSS1/PAPSS2	1.69914516568236
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/622	78/9376	1.54604666501773	ENO1/BTG1/LSM7/MPHOSPH6/LSM6/LSM3/LSM2/PABPC4	1.29080265145235
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/622	103/9376	1.46349077513814	JUN/NFKBIA/CXCL8/C1QC/MYD88/IFNGR2/CCL3L3/GNAI3/GNAQ/PPP2CB	1.26074465804287
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/622	91/9376	1.49083071269566	FCGR2B/JUN/NFKBIA/RAC1/IFITM1/GRB2/LILRA5/LILRB2/LILRB4	1.25411982011848
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/622	79/9376	1.52647645406813	ATP6V1F/SLC1A3/CLTB/AP2S1/ATP6V1G1/ATP6V0E1/STX3/ATP6V1B2	1.2525602992013
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/622	32/9376	1.88424437299035	AKR1B1/HK2/UGP2/GALK1	1.33554473158385
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/622	120/9376	1.38177920685959	CALM1/JUN/NFKBIA/RAC1/GRB2/CALM3/RAP1A/RHOA/BAX/MAP3K3/RAP1B	1.12193780115814
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/622	57/9376	1.58673210357082	ECHS1/SCD/HSD17B4/ACSL1/ACAA2/HACD4	1.18432305325387
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/622	174/9376	1.29947887792438	CAPN2/PPP1R15A/ERO1A/SEC61G/UBE2D2/SSR4/RBX1/UBXN1/SEC61B/BAX/SKP1/HSP90AB1/RNF5/BAG1/HSPH1	1.06286294501039
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/622	34/9376	1.7734064686968	RBX1/SKP1/BHLHE40/NFIL3	1.2042173680267
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/622	46/9376	1.6384733678177	FTH1/FTL/HMOX1/BLVRA/BLVRB	1.15706681995493
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/622	71/9376	1.48616457587972	LDHA/PKM/SLC16A3/HK2/PGAM1/SCO2/PTEN	1.09605375952929
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/622	47/9376	1.60361223233222	LDHA/PKM/ALDH2/ADH5/AKR1A1	1.10577552747831
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/622	72/9376	1.46552340121472	ISG15/NFKBIA/CXCL8/IFIH1/AZI2/IRF7/ZNFX1	1.05694034042175
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/622	85/9376	1.41872517495744	TYMP/NT5C3A/APRT/UPP1/GUK1/CMPK1/NME1/DGUOK	1.03367702830061
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/622	98/9376	1.38434280464597	FCGR2B/RAC1/ARPC4/CFL1/ARPC3/NCF1/GSN/WAS/ARPC1A	1.01948811714475
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/622	166/9376	1.27129740828265	CALM1/VDAC2/ADORA3/CALM3/SLC25A6/RGS2/RHOA/IRS2/KCNMA1/VDAC1/GNAI3/GNAQ/PPP1CB/CREB3	0.940042379788268
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/622	61/9376	1.48268409677929	FTH1/FTL/HMOX1/MT2A/MT1X/MT1F	1.00812419384322
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/622	100/9376	1.35665594855305	CXCR4/CXCL8/CXCL3/TNFRSF14/IL18/CCL3L3/CXCL2/PPBP/CCL13	0.955755181797866
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/622	88/9376	1.37035954399298	C5AR1/C1QC/SERPING1/SERPINA1/ITGAM/CFD/PLAUR/PLAU	0.930424917920289
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/622	37/9376	1.62961675501868	IL4I1/MIF/COMT/ADH5	1.02283247971089
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/622	37/9376	1.62961675501868	HK2/GPI/UGP2/GALK1	1.02283247971089
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/622	115/9376	1.31077869425416	JUND/SGK1/NR4A2/NACA/MAFB/RHOA/GNAI3/GNAQ/CREB3/MMP14	0.893817338859023
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/622	50/9376	1.50739549839228	P4HA1/ALDH2/SMS/GATM/CNDP2	0.958873830056837
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/622	38/9376	1.58673210357082	HK2/GPI/UGP2/GALK1	0.96601145114798
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/622	103/9376	1.31714169762432	SAP18/RBM8A/MAGOH/SSU72/PPP2CB/PPP1CB/ETF1/PABPC4/EIF4A3	0.862659458547689
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/622	90/9376	1.33990710968203	JUN/NFKBIA/CSNK2B/STAT1/MYD88/MAP3K3/IFNGR2/PTEN	0.863663812563571
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/622	105/9376	1.29205328433624	CALM1/JUN/NFKBIA/LSP1/PYCARD/STAT1/CALM3/CLEC7A/RHOA	0.802178490961599
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/622	119/9376	1.266718906212	JUN/NFKBIA/CEBPB/SOCS3/JUNB/CXCL3/TNFAIP3/CXCL2/CREB3/MMP14	0.78049425326944
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/622	27/9376	1.67488388710254	SCD/HSD17B4/HACD4	0.936064814684696
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/622	232/9376	1.16953099013194	CXCR4/RAC1/MYL12A/MYL12B/ARPC4/CFL1/PFN1/ARPC3/MSN/BRK1/GSN/RHOA/PIP4K2A/ITGAM/ARPC1A/PPP1CB/ITGB7/IQGAP2	0.696951475151227
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/622	107/9376	1.26790275565706	LDHA/CALM1/PKM/FBP1/CALM3/PGAM1/PPP4C/GNAQ/CREB3	0.742899708550721
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/622	80/9376	1.31897106109325	VEGFA/GRB2/EIF4E2/EIF4EBP1/BAX/RPS6/PTEN	0.76370525420073
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/622	28/9376	1.6150666054203	ECHS1/ACAA2/HACD4	0.868799117673922
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/622	67/9376	1.3499064164707	CALM1/CALM3/RAP1A/RAP1B/GNAQ/PPP1CB	0.766152727686482
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/622	16/9376	1.88424437299035	IL4I1/MIF	0.943565234862375
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/622	41/9376	1.47062975452906	CXCL8/TYMP/VEGFA/DAPK1	0.804992265554703
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/622	109/9376	1.24463848491106	JUN/NFKBIA/CXCL8/RAC1/STAT1/IRF7/MYD88/CCL3L3/CD86	0.684772017885238
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/622	109/9376	1.24463848491106	NFKBIA/SOCS3/IRS2/MLXIP/NR1H2/PPP1CB/PTEN/CREB3/PPP1R3B	0.684772017885238
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/622	69/9376	1.31077869425416	CALM1/JUN/CALM3/FOSB/PPP1CB/CREB3	0.690634843721681
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/622	83/9376	1.27129740828265	PRDX1/HSD17B4/ACSL1/PRDX5/ECH1/SOD1/SOD2	0.661735268674392
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/622	17/9376	1.7734064686968	PAPSS1/PAPSS2	0.850736559611642
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/622	139/9376	1.19290291239677	CALM1/JUN/GRB2/KRT19/CALM3/FKBP5/HSP90AB1/GNAI3/GNAQ/CREB3/CTSD	0.610742682528295
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/622	30/9376	1.50739549839228	SDHB/SDHD/SUCLG1	0.741945334541741
Organismal Systems	Immune system	hsa04611	Platelet activation	10/622	126/9376	1.19634563364467	MYL12A/MYL12B/RAP1A/RHOA/RAP1B/APBB1IP/GNAI3/VAMP8/GNAQ/PPP1CB	0.591443432166323
NA	NA	hsa04517	IgSF CAM signaling	22/622	299/9376	1.10912043359967	DYNLL1/RAC1/MYL12A/TUBB4B/MYL12B/JAML/ARPC4/GRB2/ARPC3/MSN/MYL6/IL1RAP/RAP1A/RHOA/TUBA1C/ITGAM/KCNQ3/CD86/RAP1B/TUBB6/ARPC1A/CSK	0.511149651310856
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/622	31/9376	1.45876983715382	ECHS1/ALDH2/CNDP2	0.681967392691241
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/622	59/9376	1.27745381219685	TYMP/NT5C3A/UPP1/CMPK1/NME1	0.569844307021163
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/622	87/9376	1.21284695272942	JUN/RAC1/CYCS/GRB2/RHOA/BAX/RALA	0.531643050372394
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/622	32/9376	1.41318327974277	LDHA/ECHS1/SUCLG1	0.624063629121907
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/622	102/9376	1.1822709791312	RAC1/RAB8A/RAP1A/RHOA/KCNMA1/RAB11A/RAP1B/GNAQ	0.493357376561028
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/622	75/9376	1.20591639871383	CYCS/SIVA1/BAX/SHISA5/CCND3/PTEN	0.477237215543809
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/622	47/9376	1.28288978586577	PKM/HK2/SOCS3/IRS2	0.518234365422513
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/622	90/9376	1.17241872097178	EIF4E2/EIF4EBP1/IRS2/BAX/SOD2/RHEB/CREB3	0.438095602210615
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/622	76/9376	1.19004907767812	CALM1/GRB2/CALM3/BAX/PTEN/CAMK1	0.44341323066751
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/622	48/9376	1.2561629153269	IL4I1/ECHS1/ALDH2/ACAA2	0.474264007334007
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/622	21/9376	1.4356147603736	ALDH2/PPCS	0.532681848097612
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/622	49/9376	1.23052693746309	JUN/FOSB/GNAI3/CREB3	0.431247203446783
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/622	122/9376	1.11201307258447	FBP1/SCD/EIF4EBP1/RAB8A/IRS2/RHEB/ELAVL1/PPP2CB/CREB3	0.331941412355314
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/622	93/9376	1.13459876223075	CALM1/JUN/GRB2/CALM3/MAP3K3/GNAQ/MMP14	0.347708994084889
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/622	36/9376	1.2561629153269	AKR1B1/UGP2/AKR1A1	0.410460744819515
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/622	36/9376	1.2561629153269	HK2/GPI/UGP2	0.410460744819515
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/622	138/9376	1.09231557854513	CALM1/YWHAH/ANAPC13/CALM3/RBX1/ANAPC11/SKP1/ANAPC16/PPP2CB/PPP1CB	0.291207877817407
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/622	22/9376	1.37035954399298	ALDH2/CNDP2	0.463568329464245
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/622	37/9376	1.22221256626401	MYD88/IL18/GNAQ	0.360991394150553
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/622	125/9376	1.08532475884244	RAC1/ADORA3/RHOA/BAX/GNAI3/GNAQ/PPP2CB/PTEN/CTSD	0.255984279304363
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/622	52/9376	1.15953499876329	TSPO/VDAC2/VAPA/VDAC1	0.307492177612204
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/622	23/9376	1.31077869425416	SSBP1/RPA2	0.397756465590499
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/622	23/9376	1.31077869425416	ANPEP/CTSA	0.397756465590499
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/622	82/9376	1.10297231589679	GSTO1/TYMP/UPP1/GSTP1/CMPK1/NME1	0.249633940326838
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/622	38/9376	1.19004907767812	IL7R/TAP1/RFXANK	0.312901892021685
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/622	53/9376	1.1376569799187	CLTB/AP2S1/RAB11A/GNAQ	0.2678772854598
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/622	69/9376	1.09231557854513	CALM1/CALM3/KCNMA1/GNAI3/GNAQ	0.20515034119248
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/622	99/9376	1.06583520088343	JUN/RAC1/GRB2/EIF4EBP1/RHEB/WAS/GPCPD1	0.175529268709524
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/622	144/9376	1.04680242943909	NFKBIA/CXCL8/C5AR1/SCD/ALDH2/C1QC/ADH5/CXCL3/MYD88/CXCL2	0.150861806796153
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/622	101/9376	1.04472955334119	JUN/CXCL8/RAC1/VEGFA/STAT1/BAX/VEGFB	0.120469150695158
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/622	163/9376	1.0172607657862	JUN/NFKBIA/CXCL8/IFIH1/CYCS/GRB2/STAT1/IRF7/MYD88/BAX/CREB3	0.0592558027018566
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/622	133/9376	1.02004206658124	SGK1/GRB2/GABARAPL2/KLF2/BNIP3/IRS2/SOD2/IL7R/PTEN	0.062049659685089
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/622	133/9376	1.02004206658124	CALM1/GNG5/COMT/CALM3/GNAI3/GNAQ/PPP2CB/PPP1CB/CREB3	0.062049659685089
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/622	103/9376	1.0244435425967	CXCL8/PRDX1/CXCL3/ITGAM/CXCL2/GNAQ/RAB7A	0.0664890595573227
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/622	42/9376	1.0767110702802	IL4I1/ECHS1/ALDH2	0.132808645816707
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/622	195/9376	1.00493033226152	FPR3/RAC1/C5AR1/VDAC2/SLC25A6/CLEC7A/NCF1/NCF2/HMGB1/VDAC1/ITGAM/HDAC5/SELPLG	0.0185449667638992
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/622	89/9376	1.0162216843094	TUBB4B/GRB2/TUBA1C/GNAI3/TUBB6/GNAQ	0.0409855516863863
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/622	89/9376	1.0162216843094	GNG5/GABARAPL2/GLUL/SLC38A2/GABRB2/GNAI3	0.0409855516863863
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/622	212/9376	0.995449857428866	CALM1/RAC1/VEGFA/PFN1/CALM3/RAP1A/RHOA/VEGFB/RALA/ITGAM/RAP1B/APBB1IP/GNAI3/GNAQ	-0.017861912369032
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/622	59/9376	1.02196304975748	GRB2/BAX/PTEN/CTNNA1	0.0451084768669276
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/622	106/9376	0.995449857428866	NFKBIA/GRB2/GSTP1/HSP90AB1/PTEN/CREB3/PLAU	-0.0125578597880095
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/622	12/9376	1.2561629153269	VKORC1	0.236675736428052
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/622	12/9376	1.2561629153269	FCGR2B	0.236675736428052
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/622	137/9376	0.990259816462084	JUN/NFKBIA/CTSH/CAPN2/CYCS/LMNA/BAX/TUBA1C/CTSD	-0.030612056058275
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/622	28/9376	1.0767110702802	AKR1B1/PCBD1	0.108356574048951
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/622	44/9376	1.02776965799474	TAF7/GTF2H5/TAF9	0.0492138185503199
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/622	44/9376	1.02776965799474	DYNLL1/RAB11A/CREB3	0.0492138185503199
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/622	122/9376	0.98845606451953	GRB2/STAT1/SOCS3/JUNB/IRS2/GNAI3/GNAQ/CREB3	-0.0342094914380299
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/622	154/9376	0.978828245709275	DHRS3/CMPK1/ALDH2/UGP2/VKORC1/NME1/PDXK/AKR1A1/PPCS/MTHFD1L	-0.0706126005258617
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/622	154/9376	0.978828245709275	CALM1/JUN/CALM3/MYL6/RGS2/RHOA/GNAI3/GNAQ/PPP1CB/CAMK1	-0.0706126005258617
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/622	29/9376	1.03958310233951	CALM1/CALM3	0.0569049788414523
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/622	77/9376	0.978828245709275	RAC1/VEGFA/STAT1/BAX/RALA	-0.049723494568658
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/622	140/9376	0.969039963252182	CALM1/GNG5/MAP1LC3B/KLF2/CALM3/RPS6/HDAC5/GNAI3/GNAQ	-0.0983787007314256
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/622	13/9376	1.15953499876329	XRCC6	0.153425552950339
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/622	62/9376	0.972513224769215	DTX3L/CIR1/PSENEN/MFNG	-0.0578800740983449
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/622	14/9376	1.0767110702802	B3GNT7	0.0765623580698244
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/622	31/9376	0.972513224769215	ALDH2/AKR1A1	-0.040859452648243
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/622	65/9376	0.927627999010636	AKR1B1/AGPAT2/ALDH2/AKR1A1	-0.15606540900159
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/622	32/9376	0.942122186495177	CYCS/BAX	-0.0874174733400336
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/622	130/9376	0.927627999010636	JUN/NFKBIA/GNG5/VEGFA/GRB2/VEGFB/GNAI3/CREB3	-0.221484261723682
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/622	98/9376	0.922895203097316	CALM1/NR4A2/CALM3/GNAQ/CREB3/CAMK1	-0.204524250921133
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/622	50/9376	0.90443729903537	CXCL8/MYD88/IL18	-0.180593981174203
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/622	68/9376	0.886703234348402	GRB2/EIF4EBP1/ITGAM/SPI1	-0.249931698404498
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/622	134/9376	0.899937610980467	CALM1/CALM3/MYL6/RHOA/KCNMA1/ADM/GNAQ/PPP1CB	-0.31096953488712
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/622	69/9376	0.873852462836106	RAC1/ALOX5/GRB2/ALOX5AP	-0.28033416133672
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/622	17/9376	0.886703234348402	HSD17B4	-0.124624895868764
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/622	17/9376	0.886703234348402	GLUL	-0.124624895868764
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/622	217/9376	0.903047994428557	JUN/KLF4/PTGES3/GSTO1/VEGFA/GRB2/EIF4EBP1/CCND3/HSP90AB1/AHR/GNAI3/CREB3/KPNA3	-0.385159127514337
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/622	70/9376	0.861368856224162	NFKBIA/ACSL1/SOCS3/IRS2	-0.310317209827823
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/622	36/9376	0.837441943551268	SSBP1/RPA2	-0.260473694411268
NA	NA	hsa04518	Integrin signaling	9/622	154/9376	0.880945421138347	RAC1/VEGFA/LIMS1/PARVB/CCND3/VEGFB/FLNA/ITGAM/ITGB7	-0.397074012030042
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/622	54/9376	0.837441943551268	LDHA/IL4I1/SMS	-0.319321667291999
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/622	204/9376	0.886703234348402	RAC1/VEGFA/GRB2/MSN/RHOA/HCLS1/FLNA/RPS6/CAV1/PPP1CB/PLAUR/PLAU	-0.436092012404541
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/622	18/9376	0.837441943551268	ACSL1	-0.184005493762124
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/622	37/9376	0.814808377509342	IL4I1/GLUL	-0.300849691409788
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/622	157/9376	0.864112069142073	RAC1/CEBPB/SGK1/ALOX5/MERTK/UQCRFS1/C1QC/NR1H2/RAB7A	-0.457684667649922
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/622	19/9376	0.793366051785412	IDS	-0.240318784712075
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/622	75/9376	0.803944265809218	GSTO1/CYCS/GSTP1/BAX	-0.454383882298947
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/622	75/9376	0.803944265809218	GPX1/GPX3/GNAQ/CREB3	-0.454383882298947
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/622	110/9376	0.822215726395791	EMP3/HAMP/RBX1/RHOA/SKP1/PPP2CB	-0.499943694993987
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/622	20/9376	0.753697749196142	UGP2	-0.293910993818145
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/622	93/9376	0.810427687307679	CALM1/LYZ/CALM3/KCNMA1/GNAQ	-0.489722171735794
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/622	194/9376	0.854708787748202	DYNLL1/MYL12A/TUBB4B/DYNLRB1/MYL12B/MYO1G/DYNLT1/MYL6/TUBA1C/TUBB6/DYNLT3	-0.545066043883447
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/622	76/9376	0.793366051785412	PLIN2/UBC/SCD/ACSL1	-0.482108241001808
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/622	76/9376	0.793366051785412	CALM1/CALM3/GNAI3/GNAQ	-0.482108241001808
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/622	128/9376	0.82435691318328	APRT/GUK1/PAPSS1/NME1/PRPS1/DGUOK/PAPSS2	-0.533322240155955
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/622	21/9376	0.717807380186801	CHST15	-0.34507298630717
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/622	41/9376	0.735314877264528	PGAM1/GATM	-0.452732693925533
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/622	41/9376	0.735314877264528	SSBP1/RPA2	-0.452732693925533
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/622	60/9376	0.753697749196142	RAC1/VEGFA/MAPKAPK3	-0.51016049488852
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/622	60/9376	0.753697749196142	GNAI3/GNAQ/PPP2CB	-0.51016049488852
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/622	298/9376	0.859923606465396	CXCR4/CXCL8/TNFSF13B/CXCL16/IL1RAP/CXCL3/TNFSF12/TNFRSF14/IL27RA/IL18/IL7R/IFNGR2/CCL3L3/CXCL2/PPBP/CCL13/LTB	-0.65502149805122
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/622	97/9376	0.777007988862002	CALM1/GNG5/CALM3/GNAI3/GNAQ	-0.588439941410028
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/622	115/9376	0.786467216552495	GNG5/DUSP1/ALOX5/GABRB2/GNAI3/GNAQ	-0.614132525134175
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/622	201/9376	0.824942810065428	NUPR1/CXCL8/CEBPB/BAX/ITGAM/CD86/SPI1/HHEX/ITGB7/PLAU/NFKBIZ	-0.668732614353517
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/622	133/9376	0.793366051785412	HLA-A/RAC1/HLA-C/GRB2/HLA-B/IFNGR2/HLA-E	-0.639732739841324
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/622	62/9376	0.729384918576911	SOD1/IRS2/SOD2	-0.569845710651253
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/622	116/9376	0.779687326754629	GNG5/SLC1A3/GLUL/SLC38A2/GNAI3/GNAQ	-0.636415195854977
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/622	23/9376	0.65538934712708	GLUL	-0.441056989509933
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/622	99/9376	0.76131085777388	CALM1/CALM3/IL1RAP/GNAQ/PPP1CB	-0.636391019115094
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/622	101/9376	0.746235395243705	CALM1/CALM3/GNAI3/GNAQ/CREB3	-0.683458790171603
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/622	83/9376	0.726455661875799	CSNK2B/PHC2/UBE2D2/SKP1	-0.667215869214606
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/622	154/9376	0.78306259656742	CALM1/CALM3/GNAI3/KCNE1/GNAQ/PPP2CB/PPP1CB/CREB3	-0.723535423534222
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/622	158/9376	0.763238227034067	YWHAH/ANAPC13/RBX1/ANAPC11/SKP1/CCND3/ANAPC16/PPP2CB	-0.800017218877661
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/622	26/9376	0.579767499381647	HHEX	-0.571936832046338
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/622	26/9376	0.579767499381647	TCN2	-0.571936832046338
NA	NA	hsa03272	Virion - Hepatitis viruses	2/622	48/9376	0.628081457663451	CD9/CHMP4B	-0.688575776338496
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/622	48/9376	0.628081457663451	SLC2A5/HK2	-0.688575776338496
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/622	178/9376	0.762166263232053	JUN/CSNK2B/RAC1/CACYBP/RBX1/RHOA/SKP1/CCND3/SERPINF1	-0.853914360698994
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/622	27/9376	0.558294629034179	ECHS1	-0.61264591453424
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/622	71/9376	0.636927675377021	GRB2/STAT1/SOCS3	-0.818543361913955
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/622	110/9376	0.685179771996492	ANAPC13/ANAPC11/HSP90AB1/ANAPC16/GNAI3	-0.885299834772319
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/622	29/9376	0.519791551169753	RASSF2	-0.690351437989719
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/622	73/9376	0.61947760207902	GSTO1/GSTP1/ADH5	-0.869976865239899
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/622	30/9376	0.502465166130761	DPM2	-0.727526456050435
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/622	93/9376	0.648342149846143	NFKBIA/CYCS/BAX/PTEN	-0.908437754646136
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/622	238/9376	0.760031343727201	CALM1/GNG5/RAC1/VEGFA/GRB2/CALM3/RAP1A/RHOA/VEGFB/RALA/SHOC2/RAP1B	-0.999528037064906
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/622	31/9376	0.486256612384607	GLUL	-0.763686297987727
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/622	362/9376	0.791174432857828	DDIT4/YWHAH/GNG5/RAC1/VEGFA/SGK1/GRB2/EIF4E2/EIF4EBP1/CCND3/VEGFB/HSP90AB1/IL7R/RPS6/RHEB/PPP2CB/PTEN/CREB3/ITGB7	-1.08008202219606
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/622	115/9376	0.65538934712708	GNG5/KCNQ3/GNAI3/GNAQ/CREB3	-0.991119991132475
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/622	226/9376	0.733688074438722	CALM1/JUN/NFKBIA/RAC1/CALM3/RAP1A/RHOA/RAP1B/GNAI3/PPP1CB/CREB3	-1.0802190867667
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/622	77/9376	0.587296947425565	NFKBIA/GRB2/BAX	-0.969264885250583
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/622	56/9376	0.538355535140101	DPM2/MGAT1	-0.923573045313586
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/622	191/9376	0.710291072540866	CALM1/GNG5/GRB2/CALM3/FOSB/HDAC5/GNAI3/PPP1CB/CREB3	-1.07824273596788
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/622	117/9376	0.644186110424052	MORF4L2/MORF4L1/KAT5/MBD2/MEAF6	-1.0323128787254
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/622	98/9376	0.615263468731544	CALM1/CALM3/PIP4K2A/PTEN	-1.02053249629839
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/622	78/9376	0.579767499381647	TPI1/PIP4K2A/PTEN	-0.993389870821773
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/622	79/9376	0.572428670275551	GSTO1/GSTP1/ADH5	-1.01725132919286
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/622	59/9376	0.51098152487874	IRS2/GNAI3	-1.00436318344154
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/622	122/9376	0.617785040324706	JUN/NFKBIA/GRB2/RHOA/PPP2CB	-1.13266220281806
NA	NA	hsa04382	Cornified envelope formation	10/622	217/9376	0.694652303406582	S100A4/S100A10/S100A6/S100A11/KRT19/S100A9/S100A8/S100A13/ST14/PPP2CB	-1.2130481645557
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/622	254/9376	0.712155353571157	CALM1/CXCR4/VEGFA/VDAC2/CALM3/SLC25A6/PTAFR/VEGFB/VDAC1/GNAQ/ORAI3/CAMK1	-1.23967413568502
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/622	37/9376	0.407404188754671	BAX	-0.962690776970129
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/622	38/9376	0.396683025892706	SGK1	-0.993317226230905
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/622	184/9376	0.65538934712708	CXCR4/RAC1/MYL12A/MYL12B/CFL1/DPYSL2/RHOA/GNAI3	-1.25837523186144
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/622	63/9376	0.478538253457868	ECHS1/ALDH2	-1.10694358444741
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/622	63/9376	0.478538253457868	PTGES3/ALOX5	-1.10694358444741
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/622	86/9376	0.525835638974052	JUN/GRB2/EIF4EBP1	-1.17746453900884
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/622	86/9376	0.525835638974052	KCNMA1/GNAQ/CREB3	-1.17746453900884
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/622	86/9376	0.525835638974052	LMNA/CTNNA1/ITGB7	-1.17746453900884
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/622	39/9376	0.386511666254432	MTHFD1L	-1.02332242659603
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/622	168/9376	0.628081457663451	GRB2/STAT1/SOCS3/CCND3/IL27RA/IL7R/IFNGR2	-1.2965742014888
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/622	65/9376	0.463813999505318	GNAQ/CREB3	-1.15624946559688
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/622	149/9376	0.607004898681456	CXCL8/GRB2/AGPAT2/RHOA/RALA/RHEB	-1.28892477114243
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/622	66/9376	0.456786514664328	COMT/HSD17B11	-1.18044356628367
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/622	41/9376	0.367657438632264	GABRB2	-1.08159517366565
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/622	300/9376	0.703451232583065	JUN/JUND/RAC1/VEGFA/DUSP1/GRB2/IL1RAP/RAP1A/MYD88/MAP3K3/VEGFB/FLNA/MAPKAPK3/RAP1B	-1.39151235406032
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/622	68/9376	0.443351617174201	DHRS3/ADH5	-1.22796158331291
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/622	91/9376	0.496943570898555	GNG5/GABRB2/GNAI3	-1.28535770491878
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/622	43/9376	0.350557092649368	AGPAT2	-1.13773765646381
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/622	155/9376	0.583507934861529	RAP1A/AHR/RAP1B/GNAI3/GNAQ/CREB3	-1.39367377933555
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/622	44/9376	0.342589885998246	MGAT1	-1.16507239915442
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/622	44/9376	0.342589885998246	HMGB1	-1.16507239915442
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/622	70/9376	0.430684428112081	GSTO1/GSTP1	-1.2743775674639
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/622	45/9376	0.334976777420507	TAP1	-1.1919458686645
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/622	73/9376	0.41298506805268	BAX/PTEN	-1.34207450897698
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/622	73/9376	0.41298506805268	GRB2/BAX	-1.34207450897698
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/622	99/9376	0.456786514664328	JUN/GRB2/BAX	-1.44831130693971
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/622	49/9376	0.307631734365772	MFNG	-1.29521470070225
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/622	52/9376	0.289883749690824	ALOX5	-1.36869773941804
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/622	170/9376	0.532021940609041	GSTO1/GRB2/HMOX1/GSTP1/BAX/PTEN	-1.64131533422469
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/622	54/9376	0.279147314517089	RPA2	-1.41601029459229
NA	NA	hsa04082	Neuroactive ligand signaling	7/622	199/9376	0.530239622550049	GNG5/ADORA3/SLC1A3/OGFR/GABRB2/GNAI3/GNAQ	-1.78537773549028
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/622	157/9376	0.480062260634485	YWHAH/CCND3/PPP2CB/PPP1CB/CTNNA1	-1.7512043191603
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/622	183/9376	0.494228032259765	CSNK2B/NOP10/SNU13/EIF6/RAN/NHP2	-1.84174385392618
NA	NA	hsa04519	Cadherin signaling	17/622	404/9376	0.634300085957149	VIM/NFKBIA/YWHAH/RAC1/LHFPL2/MYO1G/ARPC4/ARPC3/KRT19/BRK1/RHOA/SHOC2/GABRB2/ARPC1A/PPP1CB/PSENEN/CTNNA1	-2.00285019825802
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/622	63/9376	0.239269126728934	BAX	-1.61485701538502
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/622	65/9376	0.231906999752659	GNAQ	-1.65634149389452
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/622	148/9376	0.407404188754671	JUN/GRB2/BAX/PTEN	-1.93692677004086
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/622	99/9376	0.304524343109552	LMNA/ITGB7	-1.85427145085202
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/622	323/9376	0.560023095377938	VIM/DDIT4/VEGFA/GRB2/HMOX1/UBE2I/RHOA/IRS2/HDAC5/ST14/PTEN/PLAU	-2.14492662609098
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/622	104/9376	0.289883749690824	AGPAT2/GPCPD1	-1.94105109995841
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/622	105/9376	0.287122952074721	LMNA/ITGB7	-1.95804897673221
NA	NA	hsa04081	Hormone signaling	6/622	219/9376	0.41298506805268	GNG5/HAMP/RHOA/IRS2/GNAI3/GNAQ	-2.34299929708676
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/622	150/9376	0.301479099678457	GRB2/BAX/CTNNA1	-2.29877184271993
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/622	89/9376	0.169370280718234	ITGB7	-2.09866106641805
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/622	122/9376	0.247114016129882	STAT1/RHEB	-2.23111491419809
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/622	233/9376	0.388170514607455	VIM/ENO1/VCAN/LMNA/ZYX/ITGB7	-2.52081841507178
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/622	103/9376	0.146349077513814	SLC38A2	-2.32202213741378
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/622	144/9376	0.209360485887817	KLF4/GRB2	-2.54852807969378
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/622	370/9376	0.325923351003737	FPR3/TSPO/C5AR1/ADORA3/OGFR/PTAFR/ADM/GABRB2	-3.52632010247071
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/622	449/9376	0.100716848444919	CALM1/CALM3/RGS2	-5.20528387711875