category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	41/642	78/9376	7.6766514897356	HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DRA/ITGB2/HLA-DMA/CYBB/HLA-DRB1/NCF2/CYBA/FCGR2A/NCF1/HLA-DMB/HLA-DQA1/HLA-DQB1/TGFB1/FCGR1A/HLA-DQA2/FOS/TLR2/JAK2/STAT1/IL1B/ITGAM/HLA-DRB5/TLR4/TNF/JAK1/IFNGR2/C3/NFKBIA/ITGA4/PTPN6/PRKCB/HLA-DOA/NCF4/PTGS2/MYD88/IFNGR1/JUN/CR1	16.0530587916654
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	58/642	181/9376	4.67985060498098	FCER1G/HLA-DPA1/HLA-DPB1/CTSS/FCGR3A/HLA-DRA/CD14/ITGB2/HLA-DMA/CD74/HLA-DRB1/CORO1A/LSP1/FCGR2A/HLA-DMB/HLA-DQA1/CLEC7A/HLA-DQB1/TGFB1/FCGR1A/HLA-DQA2/IL10RA/TLR2/JAK2/TLR1/STAT1/IL1B/ITGAM/HLA-DRB5/TLR4/TNF/CEBPB/CLEC4E/PLK3/JAK1/TLR6/IFNGR2/C3/CTSD/SYK/ITGAX/CIITA/HLA-DOA/CARD9/CAMK2D/SPHK1/FCGR2B/MYD88/RHOA/VDR/IFNGR1/NOD2/MRC2/IL18/TCIRG1/CR1/BID/ATP6V0B	13.5531475551004
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	50/642	155/9376	4.71108431313436	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/CTSS/FCGR3A/HLA-DRA/CD14/ITGB2/HLA-DMA/CYBB/HLA-DRB1/CORO1A/HLA-C/NCF2/CYBA/FCGR2A/HLA-F/NCF1/HLA-DMB/HLA-DQA1/CLEC7A/HLA-DQB1/MSR1/FCGR1A/HLA-E/HLA-DQA2/TUBA1A/ACTB/TLR2/TAP2/ITGAM/HLA-DRB5/TLR4/OLR1/ITGA5/CD36/TLR6/C3/TAP1/ATP6V1F/HLA-DOA/MARCO/NCF4/FCGR2B/MRC2/ATP6V1B2/ATP6V0E1/TCIRG1/ATP6V0B	12.6306068693808
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	39/642	95/9376	5.99547466797836	HLA-DPA1/HLA-DPB1/CCL3L3/CCL3/HLA-DRA/ITGB2/HLA-DMA/HLA-DRB1/TNFSF13B/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/TGFB1/HLA-DQA2/FOS/TLR2/ITGAL/IL1B/VEGFA/HLA-DRB5/TLR4/TNF/ATP6V1F/ICAM1/HLA-DOA/CXCL8/LTB/CCL5/CXCL3/CXCL2/ATP6V1B2/IL18/JUN/ACP5/ATP6V0E1/CD80/TCIRG1/ATP6V0B	13.2674584360932
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	52/642	180/9376	4.2190377293181	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/CD74/HLA-DRB1/BST2/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/HLA-DQB1/B2M/HLA-E/OAS2/PILRA/HLA-DQA2/POU2F2/TLR2/JAK2/CFP/STAT1/IL1B/TAP2/HLA-DRB5/TNF/ITGA5/IRF7/TNFRSF14/JAK1/IFNGR2/C3/SOCS3/TAP1/SYK/NFKBIA/OAS1/HLA-DOA/STAT2/CARD9/BIRC3/MYD88/TAPBP/CCL5/IFNGR1/SP100/PIK3CD/BID/IFIH1/PML	11.8225020130968
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	45/642	142/9376	4.62814268790312	TYROBP/FCGR3A/NCF2/CYBA/FCGR2A/NCF1/SPI1/CSF1R/TGFB1/FCGR1A/LILRB2/FOS/LILRB1/LILRB4/LILRB3/JUNB/STAT1/IL1B/OSCAR/TNF/JAK1/LCP2/IFNGR2/SOCS3/SYK/NFKBIA/TREM2/SIRPB1/LILRA2/BTK/LILRA6/LILRA5/NCF4/STAT2/FOSB/FCGR2B/SIRPA/GRB2/IFNGR1/ITPR1/JUN/ACP5/LILRA1/PIK3CD/RELB	11.8108228125889
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	51/642	187/9376	3.98300764655905	TXNIP/CYBB/CYBA/PYCARD/GPSM3/GBP4/GBP2/OAS2/CTSB/TNFAIP3/IFI16/GBP5/STAT1/CASP1/IL1B/NAMPT/TLR4/TNF/IRF7/GBP1/JAK1/NFKBIA/PLCB2/CARD16/OAS1/P2RX7/NLRP3/PSTPIP1/TRPV2/NAIP/CXCL8/STAT2/CARD9/NLRP12/BIRC3/PRKCD/NLRC4/AIM2/MYD88/TRPM2/RHOA/CCL5/MEFV/ITPR1/CXCL3/NOD2/CXCL2/GABARAP/IL18/NLRP1/JUN	11.170885556348
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	53/642	205/9376	3.77576172023402	HLA-A/HLA-B/VIM/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-C/ISG15/CD44/HLA-F/HLA-DMB/HLA-DQA1/HLA-DQB1/B2M/LYN/HLA-E/OAS2/HLA-DQA2/TLR2/TNFAIP3/ITGAL/STAT1/TAP2/HLA-DRB5/TNF/IRF7/JAK1/TAP1/SYK/NFKBIA/CXCL10/OAS1/GADD45B/ICAM1/BTK/HLA-DOA/STAT2/RUNX3/ENTPD1/MYD88/STAT3/TAPBP/CD40/NFKBIE/NCOR2/JAK3/JUN/CDKN1A/PIK3CD/RELB/BID	10.8942496811365
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	49/642	193/9376	3.70784304230626	CCL3L3/CCL3/CXCR4/CCL4L2/NCF1/CCL4/LYN/WAS/JAK2/HCK/CXCL16/FGR/STAT1/CCR1/RAC2/DOCK2/ARRB2/NFKBIA/PLCB2/CXCL10/PREX1/PIK3R5/CCR2/GNAI2/PRKCB/VAV1/CXCL8/ELMO1/STAT2/CCR5/PRKCD/PTK2B/STAT3/RHOA/CCL5/CX3CR1/RAP1A/GNB4/GRB2/RASGRP2/JAK3/CXCL11/CXCL3/PIK3CG/CXCL2/CXCL9/CDC42/PIK3CD/PF4	10.3051996012444
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	46/642	173/9376	3.88324059568185	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/TNFSF10/HLA-DQA1/MX1/PYCARD/HLA-DQB1/OAS2/HLA-DQA2/ACTB/JAK2/STAT1/CASP1/IL1B/MX2/HLA-DRB5/TLR4/TNF/IRF7/JAK1/IFNGR2/SOCS3/NFKBIA/TLR7/CXCL10/RSAD2/OAS1/ICAM1/NLRP3/PRKCB/CIITA/HLA-DOA/CXCL8/STAT2/MYD88/CCL5/IFNGR1/IL18/PIK3CD/BID/IFIH1/PML	10.3773337178452
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	28/642	66/9376	6.19578967242519	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/HLA-DQA1/HLA-DQB1/TGFB1/HLA-DQA2/TLR2/STAT1/IL1B/HLA-DRB5/TLR4/TNF/IFNGR2/IL2RG/STAT6/HLA-DOA/TLR5/STAT3/IFNGR1/NOD2/IL18/JUN/IL21R/MAF	11.4840545847462
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	35/642	109/9376	4.68947383463374	CCL3L3/CCL3/CD14/CCL4L2/CCL4/CD86/LY96/FOS/TLR2/SPP1/TLR1/STAT1/IL1B/TLR4/TNF/IRF7/JAK1/TLR6/NFKBIA/TLR7/CXCL10/IRF5/CXCL8/MAP3K8/TLR5/TLR8/STAT2/MYD88/CCL5/CD40/CXCL11/CXCL9/JUN/CD80/PIK3CD	10.5039987311934
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	33/642	99/9376	4.8681204569055	HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DRA/ITGB2/HLA-DMA/HLA-DRB1/FCGR2A/FPR1/HLA-DMB/HLA-DQA1/HLA-DQB1/FPR3/FCGR1A/C3AR1/C5AR1/HLA-DQA2/CFD/ITGAL/ITGAM/HLA-DRB5/PTAFR/C3/C1QB/C1QA/ICAM1/SELPLG/HLA-DOA/FCGR2B/FPR2/C1QC/C2/DEFB1	10.4896347769671
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/642	82/9376	5.34305903806702	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/CTSS/HLA-DRA/HLA-DMA/CD74/HLA-DRB1/HLA-C/HLA-F/IFI30/HLA-DMB/HLA-DQA1/HLA-DQB1/B2M/HLA-E/CTSB/HLA-DQA2/CD4/TAP2/HLA-DRB5/TNF/TAP1/CIITA/HLA-DOA/PSME2/TAPBP/HSPA6/HSPA1A	10.7089744798123
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/642	112/9376	4.56386292834891	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/HLA-DQA1/HLA-DQB1/TGFB1/LY96/HLA-DQA2/IL10RA/TLR2/JAK2/STAT1/ALOX5/HLA-DRB5/TLR4/TNF/JAK1/IFNGR2/NFKBIA/PIK3R5/GNAI2/CIITA/HLA-DOA/CCR5/BIRC3/MYD88/STAT3/HSPA6/CD40/IFNGR1/PIK3CG/HSPA1A	10.2867287625799
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	33/642	100/9376	4.81943925233645	HLA-DPA1/HLA-DPB1/HLA-DRA/CD14/CD37/HLA-DMA/HLA-DRB1/CD44/HLA-DMB/HLA-DQA1/HLA-DQB1/CSF1R/FCGR1A/CD9/HLA-DQA2/IL1B/CD4/ITGAM/HLA-DRB5/TNF/ITGA5/CD36/ITGA4/CD33/IL6R/CD1D/HLA-DOA/ANPEP/CD38/IL3RA/CD2/IL7R/CR1	10.4103611362668
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	50/642	216/9376	3.38063920618438	CCL3L3/CCL3/CD14/CYBB/NCF2/CYBA/NCF1/TNFSF10/PYCARD/LYN/LY96/FOS/POU2F2/TLR2/SOD2/JAK2/CASP1/IL1B/TLR4/OLR1/TNF/IRF7/CD36/TLR6/NFKBIA/PLCB2/ICAM1/NLRP3/VAV1/NCF4/CXCL8/CAMK2D/MYD88/STAT3/RHOA/CCL5/RAP1A/HSPA6/CD40/ITPR1/CXCL3/CXCL2/HSPA1A/IL18/JUN/CDC42/PIK3CD/BID/ABCG1/ERO1A	9.59664166684935
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	34/642	109/9376	4.55548886792992	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/HLA-DQA1/HLA-DQB1/TGFB1/HLA-DQA2/FOS/JAK2/STAT1/IL1B/CD4/HLA-DRB5/JAK1/IFNGR2/RUNX1/NFKBIA/IL2RG/STAT6/IL6R/RARA/IL27RA/HLA-DOA/STAT5A/STAT3/IFNGR1/NFKBIE/JAK3/JUN/IL21R/AHR	10.1225411078747
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	38/642	138/9376	4.02149081222629	FCGR2A/PYCARD/WAS/WIPF1/FOS/ACTB/FN1/CASP1/IL1B/CD4/TLR4/TNF/ITGA5/RAC2/ARPC3/LCP2/NFKBIA/ITGA4/SKAP2/NLRP3/VAV1/CXCL8/ELMO1/ACTR2/RPS6KA1/NLRC4/PTK2B/MYD88/RHOA/MEFV/ACTR3/RHOG/IL18/JUN/CDC42/PIK3CD/ARPC4/ARPC1B	9.69434342492905
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/642	39/9376	7.48941608754693	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/HLA-E/HLA-DQA2/HLA-DRB5/TNF/HLA-DOA/CD40/CD80	11.0098348280738
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	29/642	91/9376	4.65413714011845	LYN/PIK3AP1/LILRB2/FOS/LILRB1/LILRB4/LILRB3/RAC2/SYK/NFKBIA/LILRA2/PTPN6/BTK/PRKCB/LILRA6/DAPP1/VAV1/LILRA5/IFITM1/FCGR2B/GRB2/NFKBIE/JUN/INPP5D/LILRA1/PIK3CD/CD81/CD72/RASGRP3	9.49644687380935
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/642	44/9376	6.63834607759841	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/HLA-E/HLA-DQA2/IL1B/HLA-DRB5/TNF/HLA-DOA/CD80	10.1633588651767
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/642	93/9376	4.55404816936321	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/HLA-DQA1/HLA-DQB1/HLA-DQA2/FOS/JAK2/STAT1/CD4/HLA-DRB5/JAK1/IFNGR2/NFKBIA/IL2RG/STAT6/HLA-DOA/NOTCH1/NOTCH2/STAT5A/RUNX3/IFNGR1/NFKBIE/JAK3/JUN/MAF	9.33828592248093
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	25/642	70/9376	5.21584334668447	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/ITGB2/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/HLA-E/HLA-DQA2/ACTB/ITGAL/HLA-DRB5/RAC2/ICAM1/HLA-DOA/CD40/CD80/BID	9.59839280924068
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/642	45/9376	6.490827275874	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/HLA-E/HLA-DQA2/IL1B/HLA-DRB5/TNF/HLA-DOA/CD80	10.0098254183614
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	26/642	78/9376	4.8681204569055	CD14/ITGB2/PYCARD/LY96/FOS/CASP1/IL1B/ITGAM/TLR4/TNF/ITGA5/IRF8/C3/C1QB/C1QA/NLRP3/GNAI2/IRF1/CXCL8/MYD88/RHOA/C1QC/C2/JUN/CFL1/SERPING1	9.30034542066636
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/642	56/9376	5.73742768135291	CD14/ITGB2/PYCARD/TLR2/CASP1/IL1B/ITGAM/TLR4/TNF/C3/NFKBIA/NAIP/CXCL8/TLR5/NLRC4/MYD88/HSPA6/CXCL3/CXCL2/HSPA1A/IL18/CR1	9.63995949559188
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	37/642	160/9376	3.37725856697819	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/PTPRC/ITGB2/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/VCAN/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/PECAM1/HLA-E/HLA-DQA2/ITGAL/CD4/ITGAM/HLA-DRB5/ALCAM/ITGA4/JAML/SPN/ICAM1/SELPLG/HLA-DOA/ICAM2/SIGLEC1/CD40/SELL/CD2/CD80/ICAM3	8.22264873383175
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	27/642	98/9376	4.02365058172802	FCGR3A/PTPRC/FCGR2A/MARCKS/NCF1/FCGR1A/LYN/WAS/HCK/RAC2/ARPC3/SYK/VASP/PRKCB/VAV1/ACTR2/PRKCD/SPHK1/FCGR2B/ACTR3/INPP5D/CDC42/PLA2G4A/PIK3CD/CFL1/ARPC4/ARPC1B	8.15763020050094
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	39/642	196/9376	2.90596986458135	HLA-A/HLA-B/HLA-C/HLA-F/CLEC2B/ZFP36/CD86/LYN/HLA-E/FOS/JAK2/HCK/STAT1/VEGFA/CCR1/IRF7/JAK1/C3/SYK/NFKBIA/PREX1/ICAM1/PIK3R5/CXCL8/STAT2/CCR5/PTGS2/STAT3/GNB4/IFNGR1/ITPR1/MICB/CXCL3/PIK3CG/CXCL2/JUN/CDKN1A/PIK3CD/BID	7.31087373301118
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/642	54/9376	5.13857159340025	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/HLA-E/HLA-DQA2/HLA-DRB5/HLA-DOA/CD40/CD80	8.26874048043846
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	45/642	248/9376	2.64998492613808	PTPRC/CD14/TNFSF10/NCKAP1L/PYCARD/FLNA/LY96/FOS/TUBA1A/ACTB/TLR2/CASP1/IL1B/TLR4/TNF/ARPC3/TLR6/NFKBIA/CYTH4/NLRP3/NAIP/RRAS/CXCL8/ELMO1/TLR5/ACTR2/BIRC3/NLRC4/MYD88/RHOA/CYTH1/ACTR3/RHOG/PIK3CG/IL18/JUN/S100A10/CDC42/PFN1/PIK3CD/ARPC4/STX10/MLKL/RHOB/ARPC1B	7.13944676709922
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/642	105/9376	3.75540720961282	FCER1G/LSP1/CLEC7A/PYCARD/STAT1/CASP1/IL1B/TNF/CLEC4E/PLK3/SYK/NFKBIA/NLRP3/IRF1/RRAS/STAT2/CARD9/PRKCD/PTGS2/BCL3/RHOA/ITPR1/EGR3/JUN/CLEC4D/PIK3CD/RELB	7.6977483243138
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/642	100/9376	3.79713395638629	CCL3L3/CCL3/CXCR4/CCL4L2/TNFSF10/CCL4/TNFRSF1B/CSF1R/IL10RA/CCR1/TNF/TNFRSF14/IL2RG/CXCL10/CCR2/IL6R/CXCL8/CCR5/CCL5/CX3CR1/CXCL11/CXCL3/CXCL2/IL18/CXCL9/PF4	7.62393972222052
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	18/642	50/9376	5.25757009345794	HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/CXCR4/HLA-DRB1/TNFSF13B/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/TGFB1/HLA-DQA2/HLA-DRB5/ITGA4/HLA-DOA/CD40/CD80	8.18362389300587
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/642	50/9376	5.25757009345794	ITGB2/PECAM1/TGFB1/TLR2/ITGAL/IL1B/TLR4/TNF/CD36/GYPC/ICAM1/CXCL8/HGF/MYD88/CD40/IL18/CD81/CR1	8.18362389300587
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	42/642	227/9376	2.70212853555107	HLA-A/HLA-B/CCL3L3/CCL3/CXCR4/HLA-C/CCL4L2/HLA-F/CCL4/B2M/HLA-E/IL10RA/IL1B/VEGFA/TAP2/CCR1/TNF/RAC2/PTGER4/JAK1/TAP1/NFKBIA/PLCB2/CREB5/GNAI2/PRKCB/IL6R/CXCL8/CCR5/PTGS2/PTK2B/STAT3/TAPBP/RHOA/CCL5/GNB4/GRB2/ITPR1/PTGER2/CDKN1A/PIK3CD/BID	7.03825545829824
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	30/642	133/9376	3.29421685053756	FCER1G/HLA-A/TYROBP/HLA-B/FCGR3A/ITGB2/HLA-C/HCST/CD48/TNFSF10/HLA-E/LAT2/ITGAL/TNF/RAC2/SH3BP2/LCP2/IFNGR2/SYK/ICAM1/PTPN6/PRKCB/VAV1/ICAM2/PTK2B/GRB2/IFNGR1/MICB/PIK3CD/BID	7.22437644006471
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/642	105/9376	3.61631805370123	CD14/BCL2A1/CCL4L2/TNFSF13B/CCL4/LYN/LY96/TNFAIP3/IL1B/TLR4/TNF/SYK/NFKBIA/GADD45B/ICAM1/BTK/PRKCB/CXCL8/BIRC3/LTB/PTGS2/MYD88/CD40/CXCL3/CXCL2/RELB	7.3091766050001
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	49/642	298/9376	2.40138827907755	CCL3L3/CCL3/CXCR4/CCL4L2/TNFSF13B/TNFSF10/CCL4/TNFRSF1B/CSF1R/TGFB1/IL10RA/CXCL16/IL1B/CD4/CCR1/TNF/TNFRSF14/IFNGR2/IL1RN/IL2RG/CXCL10/CCR2/IL6R/TNFSF12/IL27RA/IL13RA1/CXCL8/CCR5/IL16/LTB/RELT/CCL5/CX3CR1/CD40/IFNGR1/IL17RA/CXCL11/CSF2RB/CXCL3/CXCL2/IL18/CXCL9/IL3RA/IL7R/IL21R/PF4/IL32/OSM/CSH1	6.6652751472162
Human Diseases	Immune disease	hsa05310	Asthma	14/642	32/9376	6.38940809968847	FCER1G/HLA-DPA1/HLA-DPB1/HLA-DRA/HLA-DMA/HLA-DRB1/HLA-DMB/HLA-DQA1/HLA-DQB1/HLA-DQA2/HLA-DRB5/TNF/HLA-DOA/CD40	8.27934925956921
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/642	238/9376	2.57724024189115	CYBB/FCGR2A/ISG15/MX1/C3AR1/C5AR1/OAS2/FOS/CFD/TLR2/STAT1/CASP1/IL1B/MX2/TLR4/TNF/JAK1/C3/SYK/NFKBIA/TLR7/C1QB/CXCL10/C1QA/OAS1/NLRP3/PRKCB/IL6R/HBEGF/CXCL8/TLR8/STAT2/F13A1/MYD88/STAT3/RPL28/C1QC/C2/JUN/PIK3CD/RPS9/IFIH1	6.68201289322772
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	43/642	253/9376	2.4821641855368	CD14/CD44/PYCARD/ACTB/CASP1/IL1B/TLR4/TNF/ITGA5/ARPC3/C3/NFKBIA/CYTH4/PLCB2/NLRP3/HK2/NAIP/CXCL8/ELMO1/TLR5/ACTR2/PRKCD/NLRC4/HK3/MYD88/RHOA/CCL5/CYTH1/ACTR3/ITPR1/HCLS1/UBE2D1/IL18/CAPNS1/JUN/CDC42/UBE2D3/PFN1/PIK3CD/ARHGEF2/ARPC4/CAPN2/ARPC1B	6.47939261444411
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	39/642	224/9376	2.54272363150868	HLA-A/HLA-B/HLA-DPA1/HLA-DPB1/TSPO/HLA-DRA/ITGB2/HLA-DMA/HLA-DRB1/HLA-C/HLA-F/ZFP36/HLA-DMB/HLA-DQA1/SPI1/HLA-DQB1/TGFB1/B2M/HLA-E/HLA-DQA2/FOS/ITGAL/CD4/HLA-DRB5/TNF/JAK1/NFKBIA/IL2RG/CREB5/ICAM1/HLA-DOA/STAT5A/CD40/JAK3/JUN/CDKN1A/PIK3CD/RELB/ETS1	6.33578883125607
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/642	200/9376	2.62878504672897	FCGR2A/TNFSF10/NCKAP1L/PYCARD/WIPF1/FOS/TUBA1A/ACTB/MYO1F/MYO1G/CASP1/IL1B/TLR4/TNF/ARPC3/NFKBIA/CYTH4/PTPN6/NLRP3/NAIP/CXCL8/TLR5/ACTR2/MYD88/RHOA/CYTH1/ACTR3/LPAR5/HCLS1/IL18/JUN/CDC42/ARHGEF2/MYO5A/ARPC4/ARPC1B	6.3124598292514
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/642	103/9376	3.40295798929317	CCL3L3/CCL3/TGFB1/FOS/TLR2/IL1B/TLR4/TNF/TLR6/IFNGR2/C3/NFKBIA/C1QB/PLCB2/C1QA/GNAI2/GNA15/CXCL8/MYD88/CCL5/IFNGR1/C1QC/JUN/PIK3CD	6.64815626571367
Human Diseases	Infectious disease: viral	hsa05162	Measles	28/642	136/9376	3.00678028220634	MSN/MX1/OAS2/FOS/TLR2/TNFAIP3/STAT1/IL1B/MX2/TLR4/IRF7/JAK1/NFKBIA/TLR7/IL2RG/OAS1/STAT5A/STAT2/FCGR2B/MYD88/STAT3/HSPA6/JAK3/HSPA1A/JUN/PIK3CD/BID/IFIH1	6.39116238595274
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/642	116/9376	3.14749167472339	ITGB2/CXCR4/CYBB/MSN/NCF2/CYBA/NCF1/PECAM1/ACTB/RASSF5/ITGAL/ITGAM/RAC2/VASP/ITGA4/ICAM1/GNAI2/PRKCB/VAV1/NCF4/PTK2B/RHOA/RAP1A/CDC42/PIK3CD	6.30959594300556
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	30/642	157/9376	2.79064230013691	PECAM1/TGFB1/HAVCR2/JAK2/SGK1/CASP1/ALOX5/CEBPB/PTGER4/DUSP2/CD36/C1QB/C1QA/SIRPB1/PTPN6/SIGLEC10/STAB1/ELMO1/CAMK2D/ODC1/SPHK1/LIPA/PTGS2/ATP11A/SIRPA/CX3CR1/AXL/C1QC/PTGER2/GPR132	6.13427606201246
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	25/642	119/9376	3.06814314510851	TNFRSF1B/FOS/JUNB/TNFAIP3/IL1B/TNF/CEBPB/SOCS3/NFKBIA/CXCL10/CREB5/RHBDF2/ICAM1/IRF1/MAP3K8/BIRC3/PTGS2/BCL3/CCL5/CXCL3/NOD2/CXCL2/JUN/PIK3CD/MLKL	6.15553070687148
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/642	214/9376	2.38856377558448	HLA-A/HLA-B/CXCR4/BST2/HLA-C/APOBEC3A/HLA-F/TNFRSF1B/SAMHD1/B2M/HLA-E/FOS/AP1S2/TLR2/CD4/TAP2/TLR4/TNF/RAC2/TAP1/NFKBIA/GNAI2/PRKCB/APOBEC3C/CCR5/APOBEC3G/PTK2B/MYD88/TAPBP/GNB4/ITPR1/JUN/PIK3CD/CFL1/BID	5.5708842217949
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/642	195/9376	2.39661314801502	FCGR3A/ITGB2/CYBB/NCF2/CYBA/FCGR2A/FPR1/NCF1/CLEC7A/FPR3/FCGR1A/C5AR1/ACTB/TLR2/ITGAL/CASP1/ITGAM/TLR4/RAC2/C3/AQP9/SYK/TLR7/PLCB2/SELPLG/PRKCB/NCF4/TLR8/SIGLEC9/FPR2/PIK3CD/CR1	5.34312084487389
Organismal Systems	Immune system	hsa04611	Platelet activation	24/642	126/9376	2.78178311823172	FCER1G/FCGR2A/LYN/FERMT3/APBB1IP/ACTB/LCP2/SYK/VASP/TBXAS1/PLCB2/PIK3R5/BTK/GNAI2/RHOA/RAP1A/ITPR1/RASGRP2/P2RX1/PIK3CG/PTGIR/PTGS1/PLA2G4A/PIK3CD	5.45903406626138
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/642	168/9376	2.43406022845275	CYBB/TNFSF10/PYCARD/FTH1/FTL/JAK2/TNFAIP3/STAT1/CASP1/IL1B/TLR4/TNF/JAK1/IFNGR2/GLUL/STAT6/NLRP3/STAT5A/STAT2/CAMK2D/BIRC3/STAT3/IFNGR1/JAK3/PLA2G4A/MLKL/BID/CAPN2	5.08494120173718
NA	NA	hsa04517	IgSF CAM signaling	41/642	299/9376	2.00260473645277	ITGB2/MSN/CD48/CD86/CD84/LYN/TUBA1A/ACTB/MBP/DOK2/ITGAL/ITGAM/ITGA5/SLAMF7/ARPC3/LCP2/ITGA4/JAML/CSK/ICAM1/PTPN6/ITGAX/PRKCB/VAV1/ICAM2/ACTR2/RHOA/RAP1A/GRB2/ACTR3/MYL6/DOK1/INPP5D/CDC42/CD2/CD80/CRTAM/PIK3CD/ICAM3/ARPC4/ARPC1B	4.77684046171636
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/642	163/9376	2.41912734361562	TGFB1/FOS/TLR2/JAK2/STAT1/TLR4/TNF/IRF7/JAK1/NFKBIA/CREB5/STAT6/PRKCB/CXCL8/STAT5A/STAT2/PTK2B/MYD88/STAT3/GRB2/EGR3/JAK3/JUN/CDKN1A/PIK3CD/BID/IFIH1	4.95520005850108
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	41/642	300/9376	1.99592938733126	CD14/CSF1R/TGFB1/FLNA/DUSP1/FOS/MEF2C/IL1B/VEGFA/TNF/RAC2/DUSP2/ARRB2/GADD45B/PRKCB/NR4A1/RRAS/MAP3K2/MAP3K8/RPS6KA1/HGF/MYD88/RAP1A/MAPKAPK3/HSPA6/GRB2/DUSP10/RASGRP2/CACNA2D4/HSPA1A/RASGRP4/JUN/CDC42/STK4/PLA2G4A/TAOK3/EREG/RELB/RASGRP3/AREG/PTPN7	4.75322628061754
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/642	88/9376	2.98725573491929	ITGB2/SERPINA1/PLAUR/C3AR1/C5AR1/CFD/ITGAM/C3/C1QB/C1QA/ITGAX/F13A1/C1QC/C2/VSIG4/A2M/CR1/SERPING1	5.07785797963496
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	27/642	168/9376	2.34712950600801	IL10RA/JAK2/STAT1/JAK1/IFNGR2/SOCS3/IL2RG/STAT6/PTPN6/IL6R/IL27RA/IL13RA1/MCL1/STAT5A/STAT2/STAT3/GRB2/IFNGR1/JAK3/CSF2RB/IL3RA/CDKN1A/IL7R/IL21R/PIK3CD/OSM/CSH1	4.77669918826682
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/642	38/9376	4.2275782915232	PTPRC/CD4/TAP2/TAP1/IL2RG/BTK/CIITA/CD40/JAK3/IL7R/ADA	5.40490677714486
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/642	143/9376	2.45108162865172	HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DRA/HLA-DMA/HLA-DRB1/FCGR2A/HLA-DMB/HLA-DQA1/CD86/HLA-DQB1/FCGR1A/HLA-DQA2/HLA-DRB5/TNF/C3/C1QB/C1QA/HLA-DOA/CD40/C1QC/C2/CD80/TRIM21	4.74061845829365
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	17/642	83/9376	2.99125473858049	CCL4L2/CCL4/SAMHD1/PYCARD/IFI16/CASP1/IL1B/IRF7/NFKBIA/CXCL10/NLRP3/AIM2/CCL5/MEFV/IL18/DNASE2/MLKL	4.94008541878267
NA	NA	hsa04518	Integrin signaling	25/642	154/9376	2.37083788485658	ITGB2/TGFB1/FLNA/FERMT3/ACTB/FN1/SPP1/ITGAL/VEGFA/ITGAM/ITGA5/RAC2/C3/ITGA4/ICAM1/PARVG/ITGAX/ICAM2/LIMS1/HGF/PARVB/ARHGEF6/CDC42/PIK3CD/ICAM3	4.65029450844438
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/642	204/9376	2.14770020157596	MSN/CD44/PLAUR/TGFB1/FLNA/ACTB/TLR2/FN1/VEGFA/TLR4/TNF/ITGA5/PTPN6/PRKCB/HPSE/VAV1/RRAS/HBEGF/CAMK2D/HGF/STAT3/RHOA/GRB2/ITPR1/CD63/HCLS1/CDC42/CDKN1A/FZD2/PIK3CD	4.49322407341085
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/642	71/9376	3.08542845860208	LYN/NFKBIA/ATP6V1F/CSK/HBEGF/CXCL8/CCL5/CXCL3/CXCL2/ATP6V1B2/JUN/CDC42/ATP6V0E1/TCIRG1/ATP6V0B	4.7820359849709
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/642	201/9376	2.10709691418298	CD14/BCL2A1/SPI1/CD86/CSF1R/FCGR1A/MEF2C/LYL1/LMO2/ITGAM/CEBPB/RUNX1/BCL6/FLI1/GADD45B/BMP2K/HHEX/RARA/CXCL8/BIRC3/CD40/NFKBIZ/REL/ID2/CDKN1A/AFF1/MAF/NR4A3/PML	4.30157194453275
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/642	137/9376	2.34522591354572	CTSS/BCL2A1/TNFSF10/CTSB/FOS/TUBA1A/ACTB/TNF/CTSH/CTSZ/CTSD/NFKBIA/GADD45B/MCL1/BIRC3/ITPR1/CSF2RB/IL3RA/JUN/PIK3CD/BID/CAPN2	4.30020919162331
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/642	101/9376	2.60275747200888	CYBB/TGFB1/FN1/JAK2/STAT1/IL1B/VEGFA/TNF/PLCB2/ICAM1/PRKCB/CXCL8/STAT5A/PRKCD/STAT3/JUN/CDC42/PIK3CD	4.39054160006843
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/642	250/9376	1.92777570093458	LAPTM5/CD68/CTSS/SLC11A1/CTSB/PSAP/NPC2/AP1S2/CTSH/LITAF/CTSZ/CTSD/TLR7/ATP6V1F/PPT1/SLC15A3/TPP1/TLR8/LIPA/DMXL2/GPR155/IDS/CD63/LAMTOR4/ATP6V1B2/ACP5/DNASE2/SLC2A6/VPS13C/ATP6V0E1/ASAH1/TCIRG1/ATP6V0B	4.03106057551904
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/642	69/9376	2.96320375637726	FCER1G/LYN/ALOX5/ALOX5AP/TNF/RAC2/LCP2/SYK/BTK/VAV1/GRB2/INPP5D/PLA2G4A/PIK3CD	4.43743110396999
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/642	212/9376	1.99776641391877	ITGB2/FPR1/CSF1R/APBB1IP/ACTB/RASSF5/ITGAL/VEGFA/ITGAM/RAC2/LCP2/DOCK4/VASP/PLCB2/GNAI2/PRKCB/VAV1/RRAS/HGF/RHOA/RAP1A/RASGRP2/LPAR5/RALB/CDC42/PFN1/PIK3CD/ARAP3/RASGRP3	3.98383029243865
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/642	154/9376	2.18117085406805	FOS/ACTB/MEF2C/CAMK1D/PLCB2/PIK3R5/GNAI2/PRKCB/CAMK1/CAMK2D/PTGS2/TRPM2/CD38/RHOA/ITPR1/MYL6/CACNA2D4/RGS2/PIK3CG/JUN/CDKN1A/PRKAG2/PLA2G4A	4.00688688056056
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/642	90/9376	2.5963309103496	FOS/TLR2/JAK2/STAT1/CD4/TLR4/JAK1/IFNGR2/NFKBIA/PTPN6/MYD88/STAT3/IFNGR1/NFKBIE/JUN/PIK3CD	4.12549814931126
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/642	110/9376	2.38980458793543	TIMP1/CYBB/VEGFA/HMOX1/TLR4/IFNGR2/PRKCB/IL6R/PFKFB3/HK2/CAMK2D/HK3/STAT3/ALDOA/IFNGR1/LDHA/CDKN1A/PIK3CD	3.97512229308906
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/642	232/9376	1.88849500483403	TMSB4X/ITGB2/CXCR4/MSN/NCKAP1L/ACTB/FN1/ITGAL/ITGAM/ITGA5/RAC2/ARPC3/ITGA4/SPATA13/ITGAX/VAV1/RRAS/ACTR2/RHOA/RGCC/ARHGEF6/ACTR3/LPAR5/FGD3/CDC42/PFN1/PIK3CD/CFL1/ARPC4/ARPC1B	3.71515923478798
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/642	103/9376	2.41042857574933	CD14/ITGB2/TGFB1/TLR2/FN1/IL1B/ITGAM/TLR4/TNF/PLCB2/PRKCB/GNA15/CD1D/CXCL8/CXCL3/CXCL2/PIK3CD	3.90216958223546
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/642	94/9376	2.48584874395175	S100A8/FOS/TNFAIP3/IL1B/TNF/CEBPB/NFKBIA/CXCL10/CXCL8/FOSB/S100A9/PTGS2/IL17RA/CXCL3/CXCL2/JUN	3.92522272642267
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/642	68/9376	2.79201026204874	CD14/BCL2A1/SPI1/CSF1R/FCGR1A/ITGAM/RUNX1/RARA/STAT5A/STAT3/GRB2/PIK3CD/PML	4.02080785639896
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/642	142/9376	2.15979992102146	NCF2/CYBA/NCF1/PECAM1/DUSP1/FOS/ACTB/MEF2C/IL1B/VEGFA/KLF2/HMOX1/TNF/RAC2/MEF2A/ICAM1/RHOA/MGST1/JUN/PIK3CD/ARHGEF2	3.7755382143352
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/642	78/9376	2.62129563064143	ACTB/FN1/ITGA5/ARPC3/ELMO1/ACTR2/RHOA/ACTR3/RHOG/HCLS1/CDC42/PIK3CD/ARPC4/ARPC1B	3.89817472386712
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/642	144/9376	2.12980269989616	CD14/ALDH2/LY96/C3AR1/C5AR1/IL1B/TLR4/TNF/C3/NFKBIA/C1QB/C1QA/CXCL8/MYD88/IL17RA/C1QC/C2/CXCL3/CXCL2/PRKAG2/SCD	3.70409839617574
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/642	115/9376	2.15890559393201	MAFB/FOS/MEF2C/NR4A2/SGK1/ARRB2/MEF2A/PLCB2/CREB5/GNAI2/PRKCB/PDE4A/HBEGF/RHOA/VDR/ITPR1/CDKN1A	3.3901162882311
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/642	205/9376	1.78101967935567	HLA-A/HLA-B/HLA-C/HLA-F/LYN/HLA-E/IRF7/JAK1/C3/SYK/NFKBIA/CREB5/STAT5A/CCR5/STAT3/RHOA/GRB2/EGR3/JAK3/REL/SP100/JUN/CDC42/CDKN1A/PIK3CD	3.06532917820643
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/642	133/9376	1.97653011032254	TNFSF10/TGFB1/SOD2/SGK1/KLF2/HOMER3/PLK3/S1PR4/BCL6/GADD45B/STAT3/GRB2/GABARAP/CDKN1A/PRKAG2/STK4/IL7R/PIK3CD	3.07504546502433
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	36/642	333/9376	1.5788498779153	HLA-A/HLA-B/HLA-C/ISG15/HLA-F/MX1/HLA-E/FN1/SPP1/STAT1/VEGFA/MX2/TNF/OASL/ITGA5/PTGER4/JAK1/LFNG/ITGA4/ATP6V1F/CREB5/IRF1/NOTCH1/MFNG/NOTCH2/STAT2/PTGS2/GRB2/ATP6V1B2/CDC42/ATP6V0E1/CDKN1A/FZD2/PIK3CD/TCIRG1/ATP6V0B	2.9159384715201
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/642	156/9376	1.87235402188673	MX1/OAS2/IFIT1/STAT1/MX2/TNF/IRF7/JAK1/SOCS3/NFKBIA/CXCL10/RSAD2/OAS1/STAT2/STAT3/GRB2/CDKN1A/PIK3CD/CD81/BID	2.9787644681165
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/642	77/9376	2.27600436946231	TGFB1/STAT1/VEGFA/RAC2/JAK1/GADD45B/STAT3/ARHGEF6/RALB/CDC42/CDKN1A/PIK3CD	3.04807717440188
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/642	170/9376	1.8040681693238	MSN/WAS/TUBA1A/ACTB/ARPC3/RUNX1/VASP/CD1D/ACTR2/RHOA/RAP1A/ACTR3/MYL6/HCLS1/JUN/RAB8B/CDC42/PRKAG2/ARHGEF2/ARPC4/ARPC1B	2.86832530172844
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	24/642	203/9376	1.72662400441969	FLNA/ACTB/FN1/SPP1/VEGFA/ITGA5/RAC2/VASP/ITGA4/PARVG/PRKCB/VAV1/BIRC3/HGF/ZYX/PARVB/RHOA/RAP1A/GRB2/JUN/CDC42/EMP1/PIK3CD/CAPN2	2.837583313331
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/642	149/9376	1.86230111438667	FCER1G/LPAR6/SYK/CYTH4/PLCB2/PIK3R5/AGPAT2/RRAS/CXCL8/SPHK1/PTK2B/RHOA/CYTH1/GRB2/LPAR5/PIK3CG/RALB/PLA2G4A/PIK3CD	2.87652650252837
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/642	73/9376	2.20065719284769	CXCR4/BST2/APOBEC3A/SAMHD1/MX1/CD4/MX2/APOBEC3C/CCR5/APOBEC3G/ELL2	2.79200058525993
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/642	73/9376	2.20065719284769	RASSF5/GADD45B/PRKCB/STAT5A/HGF/STAT3/GRB2/JAK3/CDKN1A/STK4/PIK3CD	2.79200058525993
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/642	37/9376	2.76298728635177	IL1B/TNF/PLCB2/ICAM1/PRKCB/MYD88/IL18	2.9130397657788
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	27/642	250/9376	1.57727102803738	HLA-A/HLA-B/CXCR4/HLA-C/HLA-F/HLA-E/WIPF1/ARPC3/ARRB2/CYTH4/IL2RG/ARAP2/CCR5/ACTR2/SMAP2/RHOA/CYTH1/HSPA6/ACTR3/HSPA1A/CDC42/ARAP1/ACAP2/ARPC4/ARAP3/ARPC1B/PML	2.50816493702817
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/642	87/9376	2.01439467182297	TGFB1/FOS/RAC2/GADD45B/RHOA/GRB2/RALB/JUN/CDKN1A/EREG/PIK3CD/AREG	2.57708452273769
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/642	122/9376	1.7956182013176	PTPRC/FOS/CD4/TNF/LCP2/NFKBIA/PTPN6/VAV1/MAP3K8/RHOA/GRB2/NFKBIE/JUN/CDC42/PIK3CD	2.3980952899686
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/642	122/9376	1.7956182013176	FOS/JUNB/JAK2/STAT1/SOCS3/PLCB2/CREB5/GNAI2/PRKCB/STAT5A/STAT3/GRB2/ITPR1/PIK3CD/CSH1	2.3980952899686
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/642	80/9376	2.00809968847352	JAK2/VEGFA/JAK1/PRKCB/IL6R/HGF/STAT3/AXL/GRB2/NRG1/PIK3CD	2.45497444073639
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/642	60/9376	2.19065420560748	VEGFA/RAC2/PRKCB/SPHK1/PTGS2/MAPKAPK3/CDC42/PLA2G4A/PIK3CD	2.50837864066333
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/642	70/9376	2.08633733867379	TNFRSF1B/JAK2/TNF/CD36/SOCS3/NFKBIA/STAT3/NFKBIE/ACSL4/PRKAG2	2.47331118413982
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/642	70/9376	2.08633733867379	TGFB1/VEGFA/HGF/RAP1A/GRB2/JUN/CDC42/CDKN1A/PIK3CD/ETS1	2.47331118413982
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/642	51/9376	2.29088021501435	ACTB/ATP6V1F/KCNQ1/ATP6V1B2/ATP6V0E1/TCIRG1/ATP6V0B/ERO1A	2.50606984515206
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/642	42/9376	2.43406022845275	CYBB/FTH1/FTL/HMOX1/SAT1/ACSL4/SAT2	2.52525184346435
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	35/642	362/9376	1.41202388943392	CSF1R/PIK3AP1/TLR2/FN1/JAK2/SPP1/SGK1/LPAR6/VEGFA/TLR4/ITGA5/JAK1/SYK/ITGA4/IL2RG/CREB5/PIK3R5/IL6R/DDIT4/NR4A1/MCL1/HGF/GNB4/GRB2/JAK3/LPAR5/PIK3CG/IL3RA/CDKN1A/IL7R/EREG/PIK3CD/OSM/CSH1/AREG	2.16752674192564
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/642	93/9376	1.88443372525374	PLCB2/PRKCB/HBEGF/MAP3K2/CAMK2D/PRKCD/PTK2B/GRB2/ITPR1/JUN/CDC42/PLA2G4A	2.32385567452345
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/642	139/9376	1.68107756785226	FOS/CTSD/PLCB2/CREB5/GNAI2/RARA/FKBP5/HBEGF/PRKCD/HSPA6/GRB2/ITPR1/HSPA1A/GABBR1/JUN/PIK3CD	2.19323447191495
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/642	86/9376	1.86799971020793	PRKCB/HBEGF/STAT5A/CAMK2D/GRB2/NRG1/JUN/CDKN1A/EREG/PIK3CD/AREG	2.19233797808046
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/642	120/9376	1.70384215991693	ARHGDIB/IRAK3/NFKBIA/SH2B3/CAMK2D/RPS6KA1/PRKCD/RHOA/RAP1A/GRB2/NFKBIE/JUN/CDC42/PIK3CD	2.10378224662759
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/642	238/9376	1.47270870965209	CSF1R/RASSF5/VEGFA/RAC2/PRKCB/RRAS/RASAL3/HGF/RASA4/RASA3/RHOA/RAP1A/GNB4/GRB2/RASGRP2/RALB/REL/RASGRP4/CDC42/STK4/PLA2G4A/PIK3CD/ETS1/RASGRP3	2.00264082081052
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/642	28/9376	2.60792167334223	ATP6V1F/ATP6V1B2/SLC12A7/ATP6V0E1/TCIRG1	2.31010176219593
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/642	157/9376	1.58136397007758	HLA-A/HLA-B/HLA-C/HLA-F/ZFP36L2/TGFB1/HLA-E/RASSF5/ZFP36L1/GADD45B/RRAS/CXCL8/ITPR1/CDKN1A/PIK3CD/ETS1/CAPN2	1.99160216682627
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/642	125/9376	1.63568847352025	FCER1G/TNF/RAC2/CTSD/S1PR4/PLCB2/GNAI2/PRKCB/SPHK1/RHOA/ASAH1/ADORA3/PIK3CD/BID	1.93977590856475
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/642	115/9376	1.65092780712448	FOS/JAK2/PLCB2/CREB5/PIK3R5/GNAI2/PRKCB/KCNQ1/CAMK2D/GNB4/ITPR1/PIK3CG/PIK3CD	1.90414212594154
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/642	71/9376	1.85125707516125	FOS/JAK2/STAT1/SOCS3/IRF1/STAT5A/STAT3/GRB2/PIK3CD	1.95199310198869
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/642	52/9376	1.96597172298107	TSPO/NPC2/CD36/APOC1/APOE/LIPA/PLTP	1.89370144810028
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/642	99/9376	1.6227068189685	IL1B/PTGER4/PLCB2/PRKCB/TRPV2/CAMK2D/PRKCD/ITPR1/PTGER2/PLA2G4A/PIK3CD	1.68866693188043
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/642	35/9376	2.08633733867379	FBP1/PFKFB3/HK2/HK3/ALDOA	1.7456155484091
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/642	140/9376	1.46043613707165	SLC8A1/MEF2C/SPP1/KLF2/MEF2A/PLCB2/PIK3R5/GNAI2/RRAS/SPHK1/GNB4/ITPR1/PIK3CG/PRKAG2	1.48812021335555
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/642	47/9376	1.86438655796381	TNF/SOCS3/HK2/PRKCD/HK3/PIK3CD	1.6105935126026
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/642	48/9376	1.82554517133956	PLCB2/PRKCB/HK2/HK3/PIK3CD/SLC2A5	1.5545824120431
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/642	130/9376	1.46043613707165	TGFB1/FOS/VEGFA/ARRB2/NFKBIA/PLCB2/CREB5/GNAI2/GNA15/GNB4/GRB2/JUN/PIK3CD	1.43321284458322
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/642	61/9376	1.67591032122976	FTH1/FTL/SLC8A1/HMOX1/MT1X/VDR/ATP7A	1.43585017204742
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/642	50/9376	1.75252336448598	ALDH2/LAP3/SAT1/ODC1/SAT2/GATM	1.44645139139703
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/642	109/9376	1.47383463374203	TNF/CD36/SOCS3/NFKBIA/CREB5/PRKCB/RPS6KA1/PRKCD/STAT3/PRKAG2/PIK3CD	1.34901577154453
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/642	62/9376	1.64887950959703	LFNG/NOTCH1/MFNG/NOTCH2/NCOR2/DTX3L/NUMB	1.38975532435478
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/642	30/9376	1.9472481827622	IL1B/TNF/ABCC3/MTHFR	1.40882833649659
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/642	41/9376	1.78101967935567	TYMP/VEGFA/HBEGF/CXCL8/CDKN1A	1.3587617183604
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/642	76/9376	1.53730119691753	OLR1/CD36/PLIN2/FABP5/ACSL4/GK/PLTP/SCD	1.27505725975836
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/642	76/9376	1.53730119691753	ACTB/PLCB2/GNAI2/PRKCB/KCNQ1/CAMK2D/HRH2/ITPR1	1.27505725975836
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/642	76/9376	1.53730119691753	CAMK1D/GADD45B/PRKCB/CAMK1/CAMK2D/GRB2/CDKN1A/PIK3CD	1.27505725975836
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/642	65/9376	1.57277737838486	SPP1/ARRB2/PLCB2/PRKCB/ITPR1/GABBR1/PIK3CD	1.25629297360671
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/642	77/9376	1.51733624630821	TGFB1/RUNX1/NFKBIA/GADD45B/STAT5A/GRB2/CDKN1A/PIK3CD	1.23579577123805
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/642	217/9376	1.27872288499361	FOS/KLF4/JAK2/VEGFA/ARRB2/BCL6/CREB5/GNAI2/PRKCB/NOTCH2/STAT5A/RPS6KA1/STAT3/MGST1/VDR/GRB2/JUN/AHR/PIK3CD	1.12622463923617
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/642	166/9376	1.31967120819728	SLC8A1/MEF2C/MEF2A/VASP/PLCB2/CREB5/PIK3R5/GNAI2/KCNMB1/RHOA/ITPR1/RGS2/PIK3CG/KCNMA1/ADORA3	1.12661183672014
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/642	21/9376	2.08633733867379	CHST15/DSE/CSGALNACT2	1.35113584849985
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/642	67/9376	1.52582879992561	ALDH2/FBP1/HK2/ALDH3B1/HK3/ALDOA/LDHA	1.17105370810858
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/642	69/9376	1.48160187818863	CTSB/PTGER4/PLCB2/GNAI2/ITPR1/PTGER2/KCNMA1	1.08856513087984
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/642	45/9376	1.6227068189685	TAP2/TAP1/ABCC3/DEFB1/ABCG1	1.1351998945743
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/642	12/9376	2.43406022845275	ASGR1/FCGR2B	1.34763992983272
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/642	226/9376	1.22780029222838	FOS/RAC2/NFKBIA/CREB5/GNAI2/VAV1/PDE4A/RRAS/CAMK2D/RHOA/RAP1A/HCAR3/PTGER2/HCAR2/FFAR2/GABBR1/JUN/PIK3CD/ARAP3	0.939819621269475
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/642	72/9376	1.41986846659744	ISG15/TNF/IRF7/NFKBIA/CXCL10/CXCL8/IFIH1	0.969596892238419
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/642	60/9376	1.46043613707165	LYN/PLCB2/GNAI2/PRKCB/ITPR1/PLA2G4A	0.970011415724858
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/642	98/9376	1.34121686057601	NR4A2/CAMK1D/PLCB2/CREB5/PRKCB/NR4A1/CAMK1/CAMK2D/ITPR1	0.920582882022089
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/642	99/9376	1.32766921551968	WAS/FOS/RAC2/GPCPD1/PRKCB/GRB2/JUN/PLA2G4A/PIK3CD	0.888578945963459
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/642	99/9376	1.32766921551968	TGFB1/SLC8A1/ACTB/TNF/ITGA5/ITGA4/TPM3/CACNA2D4/PRKAG2	0.888578945963459
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/642	75/9376	1.36307372793354	BIRC3/MGST1/ERCC1/CDKN1A/PIK3CD/ATP7A/BID	0.855868795222757
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/642	75/9376	1.36307372793354	ASGR1/GPX1/PLCB2/CREB5/PRKCB/ASGR2/ITPR1	0.855868795222757
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/642	38/9376	1.53730119691753	HK2/HK3/RENBP/UAP1L1	0.899765278572706
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/642	63/9376	1.39089155911586	ALOX5/TBXAS1/PTGS2/LTA4H/PTGS1/PLA2G4A	0.8439725549881
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/642	115/9376	1.26994446701883	DUSP1/ALOX5/PLCB2/GNAI2/PRKCB/PTGS2/GNB4/ITPR1/PTGS1/PLA2G4A	0.789661504224374
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/642	102/9376	1.28862012094557	PLCB2/PRKCB/KCNQ1/CD38/RHOA/RAP1A/RAB3D/ITPR1/KCNMA1	0.794583793569709
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/642	254/9376	1.14994971422965	CXCR4/SLC8A1/VEGFA/PTAFR/CAMK1D/PLCB2/P2RX7/ORAI2/PRKCB/CYSLTR1/GNA15/CAMK1/CAMK2D/HGF/SPHK1/PTK2B/CD38/HRH2/ITPR1/P2RX1	0.656846704343343
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/642	16/9376	1.82554517133956	IL4I1/ALDH3B1	0.896003006523204
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/642	93/9376	1.25628915016916	WAS/ACTB/RAC2/PTPN6/HEG1/RHOA/RAP1A/CDC42	0.67340149853346
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/642	67/9376	1.30785325707909	PLCB2/PRKCB/CAMK2D/RPS6KA1/RAP1A/ITPR1	0.685608506621885
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/642	29/9376	1.51079600386723	RASSF4/MOB1A/RASSF2	0.74689048539531
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/642	42/9376	1.39089155911586	ALDH2/KYNU/IL4I1/KMO	0.688325086120675
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/642	205/9376	1.13985259478763	CYBB/NCF2/CYBA/NCF1/TGFB1/RAC2/CD36/CTSD/PLCB2/PDK4/PRKCB/NCF4/CAMK2D/PRKCD/MPC1/PIK3CD	0.548890445121778
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/642	69/9376	1.26994446701883	FOS/CREB5/PRKCB/CAMK2D/FOSB/JUN	0.61015570615267
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/642	31/9376	1.41332529394031	FBP1/PRPS2/ALDOA	0.6249276431889
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/642	31/9376	1.41332529394031	ALDH2/DPYD/ALDH3B1	0.6249276431889
NA	NA	hsa04981	Folate transport and metabolism	3/642	31/9376	1.41332529394031	ABCC3/SLCO2B1/MTHFR	0.6249276431889
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/642	71/9376	1.23417138344083	SLC16A3/SCO2/HK2/HK3/LDHA/PIK3CD	0.536971660497584
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/642	99/9376	1.18015041379527	FOS/NOTCH1/HBEGF/NOTCH2/GRB2/JUN/CDKN1A/PIK3CD	0.488534953004975
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/642	169/9376	1.12341241313204	CTSB/CTSD/DDIT4/VMP1/RRAS/PRKCD/ITPR1/GABARAP/ATG16L2/PIK3CD/TAX1BP1/RUBCN/TP53INP2	0.438924358932157
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/642	19/9376	1.53730119691753	HPSE/IDS	0.635583848280015
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/642	59/9376	1.23765774328106	TYMP/UPP1/DPYD/CDA/ENTPD1	0.496462540599032
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/642	59/9376	1.23765774328106	GPX1/LAP3/ODC1/ANPEP/MGST1	0.496462540599032
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/642	46/9376	1.26994446701883	PSMB9/PSMB8/PSME2/PSMB10	0.497575608383268
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/642	157/9376	1.11625692005476	TGFB1/FOS/IL1B/TNF/SOCS3/IL6R/CXCL8/JUN/CDC42/PRKAG2/PIK3CD/BID	0.398266053293119
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/642	33/9376	1.32766921551968	VAMP5/STX11/STX6	0.511206062235283
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/642	158/9376	1.10919200283923	SGK1/TNF/ATP6V1F/PRKCB/DDIT4/RPS6KA1/RHOA/GRB2/LAMTOR4/ATP6V1B2/FZD2/PIK3CD	0.375273227251851
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/642	20/9376	1.46043613707165	CYB5R4/UAP1L1	0.558837899184919
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/642	89/9376	1.14865763589905	TUBA1A/PLCB2/GNAI2/PRKCB/MAP3K2/GRB2/ITPR1	0.382024363608589
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/642	62/9376	1.17777107828359	SOD2/HSPA6/HSPA1A/PRKAG2/PIK3CD	0.380746038219544
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/642	275/9376	1.06213537241575	CYBB/NCF2/CYBA/NCF1/TUBA1A/IL1B/TNF/RAC2/C1QB/C1QA/CREB5/NOTCH1/NCF4/PRKCD/CCL5/HSPA6/C1QC/ITPR1/HSPA1A/PIK3CD	0.28353537691559
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/642	21/9376	1.39089155911586	ALDH2/DPYD	0.486172738057777
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/642	105/9376	1.11271324729269	TGFB1/SLC8A1/ACTB/TNF/ITGA5/ITGA4/TPM3/CACNA2D4	0.314885657353406
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/642	49/9376	1.19219276495645	CREB5/GNAI2/FOSB/JUN	0.365687945738928
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/642	134/9376	1.08987771423258	PLCB2/PRKCB/PRKCD/KCNMB1/RHOA/ITPR1/MYL6/KCNMA1/PTGIR/PLA2G4A	0.284097880994422
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/642	22/9376	1.32766921551968	ALDH2/ALDH3B1	0.417152506527191
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/642	93/9376	1.09925300639802	LYZ/CST3/PLCB2/PRKCB/CD38/ITPR1/KCNMA1	0.260787954535961
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/642	93/9376	1.09925300639802	FN1/NFKBIA/GADD45B/BIRC3/PTGS2/CDKN1A/PIK3CD	0.260787954535961
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/642	37/9376	1.18413740843647	HK2/HK3/UAP1L1	0.304256075636766
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/642	37/9376	1.18413740843647	GADD45B/TPM3/CDKN1A	0.304256075636766
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/642	38/9376	1.15297589768815	SGK1/PRKCB/PIK3CD	0.256173635919541
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/642	82/9376	1.0686118076134	TYMP/UPP1/DPYD/CDA/CES1/MGST1	0.169180775648113
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/642	53/9376	1.10221595250691	SLC8A1/PLCB2/PRKCB/VDR	0.202313717891952
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/642	97/9376	1.05392298551562	FOS/PLCB2/GNAI2/PRKCB/CAMK2D/GNB4/ITPR1	0.144729068751329
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/642	10/9376	1.46043613707165	PAPSS2	0.394947058274304
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/642	54/9376	1.081804545979	SDS/IL4I1/SDSL/LDHA	0.163443000937603
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/642	55/9376	1.06213537241575	PSAP/SPHK1/ASAH1/NEU3	0.125295523464319
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/642	144/9376	1.01419176185531	SKIL/KLF4/JAK2/JAK1/STAT3/GRB2/JAK3/ID2/FZD2/PIK3CD	0.0465281967656881
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/642	85/9376	1.03089609675646	TYMP/UPP1/CDA/ENTPD1/AMPD3/ADA	0.0775761831204935
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/642	41/9376	1.0686118076134	SDS/SDSL/GATM	0.119365875248511
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/642	86/9376	1.01890893284069	PLCB2/CREB5/PRKCB/CAMK2D/KCNMB1/KCNMA1	0.0477589693914531
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/642	116/9376	1.00719733591148	HOMER3/GLUL/PLCB2/GNAI2/PRKCB/GNB4/ITPR1/PLA2G4A	0.0211466624071517
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/642	57/9376	1.02486746461168	PPT1/ACSL4/HACD4/SCD	0.0510541251916593
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/642	27/9376	1.081804545979	HACD4/SCD	0.115404647621324
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/642	133/9376	0.988265055161268	FOS/ARRB2/PLCB2/CREB5/GNAI2/PRKCB/CAMK2D/GNB4/ITPR1	-0.036952766255959
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/642	89/9376	0.984563687913473	CD44/FN1/SPP1/ITGA5/CD36/ITGA4	-0.0396686471277109
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/642	89/9376	0.984563687913473	GLUL/GNAI2/PRKCB/GNB4/GABARAP/GABBR1	-0.0396686471277109
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/642	28/9376	1.04316866933689	PPT1/HACD4	0.0620204458712994
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/642	59/9376	0.990126194624848	GNAI2/PTGS2/PTGS1/PIK3CD	-0.0206261930886513
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/642	59/9376	0.990126194624848	GADD45B/GRB2/CDKN1A/PIK3CD	-0.0206261930886513
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/642	75/9376	0.973624091381101	SDS/GLUL/SDSL/PRPS2/ALDOA	-0.0621755731571273
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/642	227/9376	0.965045905553954	NCF2/CYBA/NCF1/FOS/SOD2/VEGFA/HMOX1/NFKBIA/PRKCD/HGF/MGST1/GRB2/JUN/AHR/PIK3CD	-0.144534235156984
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/642	91/9376	0.962924925541748	ARRB2/GNAI2/PRKCB/PDE4A/GNB4/GABBR1	-0.096351467236915
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/642	107/9376	0.95542551023379	FBP1/PLCB2/CREB5/CAMK2D/ITPR1/LDHA/PRKAG2	-0.125721162117439
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/642	154/9376	0.94833515394263	SLC8A1/PLCB2/CREB5/PIK3R5/GNAI2/KCNQ1/CAMK2D/TPM3/CACNA2D4/PIK3CG	-0.175262700684221
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/642	46/9376	0.95245835026412	FTH1/FTL/HMOX1	-0.0876312285712632
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/642	170/9376	0.944988088693421	TGFB1/ACTB/HMOX1/GADD45B/PRKCB/HGF/MGST1/GRB2/CDKN1A/FZD2/PIK3CD	-0.196242138561211
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/642	155/9376	0.942216862626872	PLCB2/CREB5/GNAI2/NR4A1/CAMK2D/RAP1A/ITPR1/CDKN1A/FZD2/AHR	-0.196663840068617
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/642	110/9376	0.929368450863778	EMP3/TGFB1/SKIL/TNF/HAMP/RHOA/ID2	-0.202020520009865
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/642	79/9376	0.924326669032691	ATP6V1F/ATP6V1B2/ATP6V0E1/TCIRG1/ATP6V0B	-0.183118212207362
NA	NA	hsa03272	Virion - Hepatitis viruses	3/642	48/9376	0.912772585669782	CD9/CD63/CD81	-0.164257764291347
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/642	32/9376	0.912772585669782	HK2/HK3	-0.134001028478577
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/642	32/9376	0.912772585669782	BIRC3/BID	-0.134001028478577
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/642	15/9376	0.973624091381101	ST3GAL5	-0.0277165068623742
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/642	65/9376	0.898729930505631	PLCB2/CREB5/NR4A1/ITPR1	-0.222119241338046
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/642	49/9376	0.894144573717337	LFNG/MFNG/ST6GAL1	-0.201412646263749
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/642	34/9376	0.859080080630383	BHLHE40/PRKAG2	-0.223171365904733
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/642	51/9376	0.859080080630383	LPCAT2/PLA2G7/PLA2G4A	-0.273577018538106
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/642	116/9376	0.881297668922548	FBP1/SDS/HK2/SDSL/HK3/PRPS2/ALDOA	-0.348762118804519
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/642	148/9376	0.888103056327355	FOS/GADD45B/NOTCH1/NOTCH2/GRB2/JUN/CDKN1A/FZD2/PIK3CD	-0.371999064467589
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/642	17/9376	0.859080080630383	PAPSS2	-0.157662599024576
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/642	17/9376	0.859080080630383	GLUL	-0.157662599024576
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/642	52/9376	0.842559309849029	ALOX5/PTGS2/PLA2G4A	-0.308648437460155
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/642	86/9376	0.849090777367239	SLC8A1/ACTB/ITGA5/ITGA4/CACNA2D4	-0.381156832346349
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/642	36/9376	0.811353409484251	HK2/HK3	-0.307449174386504
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/642	18/9376	0.811353409484251	ACSL4	-0.217190212883542
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/642	18/9376	0.811353409484251	NEU3	-0.217190212883542
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/642	18/9376	0.811353409484251	TCN2	-0.217190212883542
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/642	184/9376	0.873086821075444	CXCR4/PLXNC1/RAC2/GNAI2/SEMA4A/RRAS/CAMK2D/RHOA/CDC42/PIK3CD/CFL1	-0.471364840028922
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/642	37/9376	0.789424938957649	GLUL/IL4I1	-0.347939846898743
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/642	37/9376	0.789424938957649	IL4I1/ALDH3B1	-0.347939846898743
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	14/642	233/9376	0.877515275493696	VIM/VCAN/ACTB/FN1/FMNL1/ITGA5/ITGA4/FHL3/PDLIM7/TNNI2/TPM3/ZYX/AMPD3/SUN2	-0.513289155459941
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/642	105/9376	0.834534935469515	BNIP3L/RRAS/USP15/GABARAP/JUN/TAX1BP1	-0.462257781274005
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/642	138/9376	0.846629644679218	FBP1/SOCS3/HK2/HK3/RHOQ/GRB2/PRKAG2/PIK3CD	-0.492083209277587
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/642	122/9376	0.837955160614882	FBP1/CD36/CREB5/PFKFB3/PRKAG2/PIK3CD/SCD	-0.488423926764899
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/642	122/9376	0.837955160614882	ACTB/STAT1/PLCB2/PRKCB/NOTCH1/NOTCH2/PIK3CD	-0.488423926764899
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/642	38/9376	0.768650598458764	NAMPT/CD38	-0.387418006733625
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/642	73/9376	0.800238979217343	GADD45B/HGF/CDKN1A/PIK3CD	-0.464523004784138
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/642	56/9376	0.78237650200267	ST6GAL1/MGAT4A/MGAT1	-0.442831394395907
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/642	20/9376	0.730218068535826	LIPA	-0.327438173676685
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	22/642	370/9376	0.868367432853414	TSPO/FPR1/FPR3/C3AR1/C5AR1/LPAR6/PTGER4/PTAFR/C3/P2RY13/S1PR4/P2RX7/CYSLTR1/FPR2/HRH2/PTGER2/P2RX1/P2RY11/GABBR1/PTGIR/ADORA3/CSH1	-0.700397843620442
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/642	323/9376	0.859080080630383	VIM/MARCKS/ZEB2/CD44/VEGFA/HMOX1/ITGA5/PRKCB/DDIT4/NOTCH1/MCL1/NOTCH2/PTGS2/STAT3/RHOA/GRB2/BMF/CDKN1A/PIK3CD	-0.698753418256594
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/642	78/9376	0.748941608754693	PLCB2/PIK3CG/INPP5D/PIK3CD	-0.603634190132253
NA	NA	hsa04519	Cadherin signaling	24/642	404/9376	0.867585824002961	VIM/NCKAP1L/ACTB/MYO1F/MYO1G/RAC2/ARPC3/LHFPL2/NFKBIA/VASP/VAV1/RRAS/TMC6/ACTR2/PTK2B/MOB1A/RHOA/ACTR3/CDC42/FZD2/TMC8/TAOK3/ARPC4/ARPC1B	-0.73761050083977
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/642	43/9376	0.679272621893791	ALDH2/ACSL4	-0.57148677847831
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/642	43/9376	0.679272621893791	CD36/AGPAT2	-0.57148677847831
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/642	23/9376	0.634972233509413	GLUL	-0.475183016753604
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/642	23/9376	0.634972233509413	POLD4	-0.475183016753604
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/642	23/9376	0.634972233509413	ANPEP	-0.475183016753604
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/642	98/9376	0.745120478097781	PLCB2/PRKCB/ITPR1/INPP5D/PIK3CD	-0.687649855417655
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/642	44/9376	0.663834607759841	MGAT4A/MGAT1	-0.605952432214816
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/642	44/9376	0.663834607759841	ARHGDIB/CREB5	-0.605952432214816
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/642	63/9376	0.695445779557929	GADD45B/CDKN1A/FZD2	-0.657561918554296
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/642	24/9376	0.608515057113188	HS3ST1	-0.52061298179718
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/642	101/9376	0.722988186669134	PLCB2/GNAI2/PRKCB/CAMK2D/FZD2	-0.758837136235679
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/642	65/9376	0.674047447879224	ALDH2/AGPAT2/GK	-0.7149233129863
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/642	47/9376	0.621462185987937	ALDH2/LDHA	-0.705321643315193
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/642	26/9376	0.56170620656602	PLA2G4A	-0.606726197837696
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/642	26/9376	0.56170620656602	HHEX	-0.606726197837696
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/642	26/9376	0.56170620656602	TCN2	-0.606726197837696
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/642	48/9376	0.608515057113188	ALDH2/IL4I1	-0.737204489736164
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/642	174/9376	0.755398001933613	HSPA6/HSPA1A/UBE2D1/FBXO6/PPP1R15A/UBE2D3/HERPUD1/CAPN2/ERO1A	-0.882958045972699
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/642	157/9376	0.74417128003651	ITGB2/TGFB1/ACTB/BIRC3/MOB1A/ID2/FZD2/AREG	-0.876402837533401
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/642	106/9376	0.688884970316817	NFKBIA/CREB5/GRB2/CDKN1A/PIK3CD	-0.873334498438129
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/642	28/9376	0.521584334668447	GCH1	-0.687339992903577
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/642	70/9376	0.625901201602136	SULT1A1/PTGS2/MGST1	-0.851726907573917
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/642	90/9376	0.6490827275874	SOD2/CREB5/PRKAG2/PIK3CD	-0.906897528897991
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/642	128/9376	0.684579439252336	PDE4A/ENTPD1/PRPS2/PAPSS2/AMPD3/ADA	-0.974131601102798
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/642	30/9376	0.48681204569055	PLA2G4A	-0.763256921614353
NA	NA	hsa04082	Neuroactive ligand signaling	10/642	199/9376	0.733887506066156	P2RY13/PLCB2/GNAI2/PRKCB/GNB4/HRH2/P2RX1/P2RY11/GABBR1/ADORA3	-1.02869823780105
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/642	31/9376	0.471108431313436	ALDH2	-0.799658202310523
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/642	31/9376	0.471108431313436	GLUL	-0.799658202310523
NA	NA	hsa04081	Hormone signaling	11/642	219/9376	0.733552397615898	JAK2/PLCB2/HAMP/GNAI2/GNA15/STAT5A/STAT3/RHOA/GNB4/PIK3CD/CSH1	-1.08169251714026
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/642	75/9376	0.58417445482866	GADD45B/CDKN1A/BID	-0.980219941537012
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/642	150/9376	0.68153686396677	TGFB1/GADD45B/HGF/GRB2/CDKN1A/FZD2/PIK3CD	-1.06596913588757
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/642	32/9376	0.456386292834891	LDHA	-0.83511355248256
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/642	32/9376	0.456386292834891	GABARAP	-0.83511355248256
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/642	78/9376	0.56170620656602	PABPC1/BTG2/BTG1	-1.05381508153219
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/642	36/9376	0.405676704742125	POLD4	-0.968605931048856
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/642	103/9376	0.567159664882194	SLC7A7/SLC8A1/KCNE3/KCNQ1	-1.19751997279548
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/642	142/9376	0.617085691720416	UBE2L6/SOCS3/BIRC3/UBE2D1/UBE2D3/PML	-1.24651465957339
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/642	104/9376	0.56170620656602	LPCAT2/GPCPD1/AGPAT2/PLA2G4A	-1.21854574458983
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/642	63/9376	0.463630519705286	ALDH2/KMT2E	-1.1580734097351
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/642	63/9376	0.463630519705286	POLD4/ERCC1	-1.1580734097351
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/642	39/9376	0.374470804377346	MTHFR	-1.06126237415401
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/642	87/9376	0.503598667955742	SLC8A1/TPM3/CACNA2D4	-1.26111485540304
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/642	41/9376	0.356203935871134	POLD4	-1.12002996786338
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/642	149/9376	0.588095088753685	PLCB2/GNAI2/PRKCB/PTGS2/GNB4/ITPR1	-1.37406223180446
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/642	110/9376	0.531067686207873	GNAI2/RPS6KA1/PIK3CD/STK10	-1.34124128721866
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/642	44/9376	0.331917303879921	POLD4	-1.20424750429212
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/642	194/9376	0.602241706008928	TUBA1A/ACTB/MYO1F/MYO1G/TNNI2/TPM3/MYL6/MYO5A	-1.51774224830939
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/642	138/9376	0.529143527924511	ATP6V1F/ATP6V1B2/ATP6V0E1/TCIRG1/ATP6V0B	-1.51072587269825
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/642	73/9376	0.400119489608671	ALDH3B1/MGST1	-1.3949583162253
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/642	178/9376	0.574328817949526	RAC2/PLCB2/PRKCB/CAMK2D/RHOA/JUN/FZD2	-1.55447630484353
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/642	79/9376	0.369730667613076	ALDH3B1/MGST1	-1.52515809573229
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/642	54/9376	0.27045113649475	ERCC1	-1.45761649496257
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/642	83/9376	0.35191232218594	UBE2D1/UBE2D3	-1.60783471106479
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/642	83/9376	0.35191232218594	SOD2/ACSL4	-1.60783471106479
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/642	56/9376	0.260792167334223	ARRB2	-1.50417780386831
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/642	86/9376	0.339636310946896	PLCB2/GABBR1	-1.66790423755975
NA	NA	hsa04382	Cornified envelope formation	8/642	217/9376	0.538409635786784	S100A8/S100A4/S100A6/S100A12/S100A11/S100A9/PADI2/S100A10	-1.86513009659338
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/642	90/9376	0.3245413637937	AQP9/ABCC3	-1.74563014193287
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/642	144/9376	0.405676704742125	PLCB2/PRKCB/ITPR1/PIK3CD	-1.94851009382161
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/642	66/9376	0.221278202586614	HSD17B11	-1.72117891439836
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/642	68/9376	0.214770020157596	ALDH1A1	-1.76185312042842
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/642	235/9376	0.497169748790349	ACTB/CREB5/RPS6KA1/GRB2/ACSL4/PRKAG2/ZNF516/SLC25A20	-2.11643547720471
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/642	154/9376	0.379334061577052	ALDH2/KYNU/GCH1/KMO	-2.10548558433566
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/642	138/9376	0.317486116754707	CAMK2D/RPS6KA1/ITPR1	-2.18982098164536
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/642	191/9376	0.382313124887867	CREB5/GNAI2/FOSB/GNB4/GRB2	-2.33825587978135
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/642	117/9376	0.249647202918231	ACTB/BAZ2B	-2.21423113414894
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/642	158/9376	0.277298000709807	TGFB1/GADD45B/CDKN1A	-2.48379647376117
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/642	103/9376	0.141789916220549	PABPC1	-2.37437140857185
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/642	268/9376	0.381457199981401	DUSP1/TUBA1A/LRRK2/UBE2L6/GNAI2/CAMK2D/ITPR1	-2.78530141928343
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/642	108/9376	0.135225568247375	NUP214	-2.45057649860543
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/642	388/9376	0.451681279506696	CYBB/TUBA1A/IL1B/TNF/PLCB2/APOE/PTGS2/ITPR1/FZD2/PIK3CD/BID/CAPN2	-2.99063879691903
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	11/642	368/9376	0.436543410537722	TNFRSF1B/TUBA1A/ACTB/GPX1/CASP1/TNF/NUP214/CHCHD10/NRG1/PFN1/BID	-2.98962516997667
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/642	480/9376	0.48681204569055	CYBB/TNFRSF1B/TUBA1A/GPX1/LRRK2/UBE2L6/IL1B/TNF/PLCB2/PRKCB/CAMK2D/PTGS2/ITPR1/FZD2/BID/CAPN2	-3.12929311033982
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	6/642	308/9376	0.284500546182789	TUBA1A/SOD2/GPX1/PLCB2/CREB5/ITPR1	-3.46158872434775
Genetic Information Processing	Translation	hsa03010	Ribosome	2/642	222/9376	0.131570823159608	RPL28/RPS9	-3.55019328121093
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/642	243/9376	0.120200505108778	HSPA6/HSPA1A	-3.76726937149203
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/642	449/9376	0.130105669226873	SLC8A1/ARRB2/CAMK2D/RGS2	-5.12133826577241