category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	51/287	222/9376	7.50503813918448	RPS4Y1/RPS3/RPS10/RPL3/RPL36A/RPL4/RPS16/RPL13/RPS3A/RPL10/RPS20/RPL9/MRPL54/RPL26/RPL23A/RPL18A/RPS13/RPL8/MRPL51/RPL29/RPL27A/RPL7/RPS2/RPSA/RPS5/RPL10A/RPL5/RPL7A/RPS26/RPS23/RPLP1/RPS6/RPS4X/RPL17/RPL19/RPL14/RPL35A/RPL23/RPL6/RPL24/RPS18/RPL15/RPS9/MRPL52/RPS8/RPL11/RPL31/RPS14/RPS27L/MRPL11/RPL18	17.429680058575
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/287	268/9376	6.33875916584326	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/CALM1/UBC/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/NDUFB10/PSMA2/NDUFB8/COX7A2L/NDUFAB1/PSMC1/PARK7/TUBA1C/UBE2L3/TUBB4B/PSMB7/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/PSMB4/NDUFA2/NDUFA10/PSMD7/SLC25A6/PSMB6/PSMB2/NDUFA13/ADRM1/SLC25A5/PSMA3/NDUFA12/PSMD6/NDUFS5/PSMA4	15.7566813013127
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	52/287	275/9376	6.17740893253088	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/CAV1/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/NDUFB10/CSNK2B/PSMA2/NDUFB8/COX7A2L/NDUFAB1/PSMC1/TUBA1C/TUBB4B/PSMB7/RAC1/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/CSNK2A2/PSMB4/NDUFA2/NDUFA10/PSMD7/SLC25A6/PSMB6/PSMB2/NDUFA13/ADRM1/SLC25A5/PSMA3/NDUFA12/PSMD6/NDUFS5/PSMA4	15.4846999099668
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	54/287	308/9376	5.72767998551971	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/MT-CO3/UQCRH/MT-CO2/GPX3/MT-ND5/MT-ND4/NDUFV2/PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/NDUFB10/PSMA2/NDUFB8/CLTB/COX7A2L/NDUFAB1/PSMC1/GPX1/TUBA1C/TUBB4B/PSMB7/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/POLR2H/PSMB4/NDUFA2/NDUFA10/PSMD7/SLC25A6/DCTN3/PSMB6/PSMB2/NDUFA13/ADRM1/SLC25A5/PSMA3/NDUFA12/PSMD6/NDUFS5/POLR2E/PSMA4	14.9911934711659
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/287	238/9376	6.45143911223026	RPS4Y1/RPS3/RPS10/RPL3/RPL36A/RPL4/RPS16/RPL13/RPS3A/RPL10/RPS20/RPL9/RPL26/RPL23A/RPL18A/RPS13/RPL8/RPL29/RPL27A/RPL7/RPS2/RPSA/RPS5/RPL10A/RPL5/RPL7A/RPS26/RPS23/RPLP1/RPS6/RPS4X/RPL17/RPL19/RPL14/RPL35A/RPL23/RPL6/RPL24/RPS18/RPL15/RPS9/RPS8/RPL11/RPL31/RPS14/RPS27L/RPL18	15.1370972909817
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/287	368/9376	4.88259354643236	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/ACTG1/MT-CO3/UQCRH/MT-CO2/RAB1A/GPX3/MT-ND5/MT-ND4/HNRNPA1/NDUFV2/SRSF3/PSMD8/PSMB1/PSMD4/PSMC4/NDUFB10/PSMA2/NDUFB8/COX7A2L/NDUFAB1/PSMC1/GPX1/TUBA1C/TUBB4B/PSMB7/RAC1/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/PSMB4/NDUFA2/NDUFA10/PSMD7/DCTN3/PSMB6/PSMB2/NDUFA13/CHCHD10/ADRM1/PFN1/PSMA3/NDUFA12/PSMD6/NDUFS5/PSMA4	13.5020646699516
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	59/287	480/9376	4.01556329849013	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/CALM1/UBC/MT-CO3/UQCRH/MT-CO2/RAB1A/GPX3/MT-ND5/MT-ND4/NDUFV2/PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/NDUFB10/CSNK2B/PSMA2/NDUFB8/COX7A2L/NDUFAB1/PSMC1/GPX1/PARK7/TUBA1C/UBE2L3/TUBB4B/PSMB7/RAC1/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/CSNK2A2/PSMB4/NDUFA2/NDUFA10/PSMD7/SLC25A6/DCTN3/PSMB6/PSMB2/NDUFA13/ADRM1/SLC25A5/PSMA3/NDUFA12/PSMD6/NDUFS5/PSMA4	12.0520303157479
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/287	388/9376	4.37831818671648	GAPDH/MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/CALM1/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/NDUFB10/CSNK2B/PSMA2/NDUFB8/COX7A2L/NDUFAB1/PSMC1/TUBA1C/TUBB4B/PSMB7/MT-ND4L/MT-ND3/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/UQCRC2/CSNK2A2/PSMB4/NDUFA2/NDUFA10/PSMD7/SLC25A6/PSMB6/PSMB2/NDUFA13/ADRM1/SLC25A5/PSMA3/NDUFA12/PSMD6/NDUFS5/PSMA4	12.0768429018714
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/287	46/9376	13.4937130737767	PSMD8/PSMB1/PSMD4/PSMC4/PSMA2/PSMC1/PSMB7/PSMC3/PSMB5/PSMD11/PSMB4/PSMD7/PSMB6/PSMB2/ADRM1/POMP/PSMA3/PSMD6/PSMA4	15.093784902787
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/287	138/9376	6.15502701610867	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/ATP6V0E1/NDUFV2/NDUFB10/NDUFB8/COX7A2L/NDUFAB1/MT-ND4L/MT-ND3/CYCS/UQCRC2/NDUFA2/NDUFA10/ATP6V1D/NDUFA13/NDUFA12/NDUFS5	10.8405182459587
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/287	227/9376	4.46140385884664	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/GSTO1/VDAC2/NDUFB10/NDUFB8/COX7A2L/NDUFAB1/RAC1/MT-ND4L/MT-ND3/ACP1/VDAC1/UQCRC2/HMOX1/NDUFA2/NDUFA10/SLC25A6/NDUFA13/SLC25A5/NDUFA12/NDUFS5	9.38095220230858
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	29/287	205/9376	4.62146681397128	GAPDH/MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/VDAC2/NDUFB10/NDUFB8/COX7A2L/NDUFAB1/RAC1/MT-ND4L/MT-ND3/VDAC1/UQCRC2/NDUFA2/NDUFA10/SLC25A6/NDUFA13/SLC25A5/NDUFA12/NDUFS5	9.31583158225787
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/287	144/9376	5.21796360820751	PSMD8/PSMB1/PSMD4/VDAC2/PSMC4/PSMA2/PSMC1/PSMB7/PSMC3/PSMB5/PSMD11/VDAC1/CYCS/PSMB4/PSMD7/SLC25A6/PSMB6/PSMB2/ADRM1/SLC25A5/PSMA3/PSMD6/PSMA4	9.06368307562898
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/287	235/9376	3.75345837348951	MT-ATP6/MT-ND1/MT-CO1/MT-CYB/MT-ND2/ACTG1/MT-CO3/UQCRH/MT-CO2/MT-ND5/MT-ND4/NDUFV2/NDUFB10/NDUFB8/COX7A2L/NDUFAB1/RPS6/COX14/MT-ND4L/MT-ND3/COX20/UQCRC2/NDUFA2/NDUFA10/NDUFA13/NDUFA12/NDUFS5	7.59598549521452
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/287	157/9376	4.16165471936794	MT-CO1/MT-CYB/MT-CO3/UQCRH/MT-CO2/LEP/NDUFV2/NDUFB10/NDUFB8/COX7A2L/NDUFAB1/RAC1/CYCS/UQCRC2/NDUFA2/NDUFA10/NDUFA13/CEBPA/NDUFA12/NDUFS5	7.09889729504729
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/287	248/9376	2.89805552433405	GAPDH/ACTG1/RPS3/ARF1/DYNLL1/RHOA/TUBA1C/TUBB4B/RAC1/BRK1/ACTR3/ARPC5L/RAB7A/CYCS/MYL12A/DCTN3/DYNLT1/ARPC1A/PFN1/RHOB/SNX9/ARPC3	5.3828895950476
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/287	149/9376	3.50807941444707	MT-ND1/MT-ND2/MT-ND5/MT-ND4/NDUFV2/NDUFB10/NDUFB8/NDUFAB1/MT-ND4L/GNG11/MT-ND3/NDUFA2/NDUFA10/NDUFA13/NDUFA12/NDUFS5	5.48368743431653
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/287	200/9376	2.94020905923345	GAPDH/ACTG1/RPS3/RAB1A/ARF1/NCL/EZR/RHOA/TUBA1C/TUBB4B/RAC1/BRK1/ACTR3/ARPC5L/TMBIM6/CYCS/ARPC1A/ARPC3	4.92839329788087
Genetic Information Processing	Transcription	hsa03040	Spliceosome	20/287	243/9376	2.68880572403608	SRSF9/SNRPE/HNRNPA1/SNRPD2/SRSF3/SNRPD1/SNRPB/MAGOH/HNRNPC/HNRNPM/PUF60/LSM4/SNU13/SF3B5/SNRPF/LSM7/EIF4A3/SNRPA1/SNRPC/PRPF31	4.73963213251257
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/287	78/9376	3.76949879388904	ACTG1/CAV1/CLTB/RHOA/RAC1/ACTR3/ARPC5L/ARPC1A/ARPC3	4.36437687159408
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/287	116/9376	3.09792142256398	GAPDH/ALDOA/PKM/ENO1/TPI1/GCSH/MDH2/ECHS1/PGK1/PGAM1/IDH2	4.03999896485426
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/287	67/9376	3.90077487128816	GAPDH/LDHA/ALDOA/PKM/ENO1/TPI1/PGK1/PGAM1	4.23417150995025
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/287	87/9376	3.37955064279707	MT-CO1/MT-CYB/MT-CO3/UQCRH/MT-CO2/COX7A2L/TPM4/UQCRC2/ATP1B3	3.96222041974597
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/287	253/9376	2.19514949525554	ACTG1/UBC/ARF1/RHOA/RAC1/ACTR3/ARPC5L/VDAC1/CYCS/UBE2N/MYL12A/RRAGA/ARPC1A/BNIP3/PFN1/ARPC3/UBE2D2	3.42438188064299
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/287	75/9376	3.48469221835076	GAPDH/ALDOA/PKM/ENO1/TPI1/PGK1/PGAM1/IDH2	3.83890128119755
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/287	105/9376	2.80019910403186	UBC/TOMM20/BNIP3L/CSNK2B/RAB7A/CSNK2A2/TAX1BP1/FKBP8/BNIP3	3.29625221826356
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/287	110/9376	2.67291732657586	GAPDH/LDHA/ALDOA/ENO1/FLT1/PGK1/RPS6/HMOX1/EIF4E2	3.13612387498121
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/287	205/9376	2.07169202005609	PSMD8/PSMD4/CALR/PSMC4/PSMC1/RAC1/LYN/PSMC3/PSMD11/CYCS/PSMD7/ADRM1/PSMD6	2.75681177813809
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/287	31/9376	4.21535348994043	SEC11A/SPCS1/SPCS2/SRP9	3.18631313836635
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/287	170/9376	2.11387579422013	ACTG1/EZR/RHOA/TUBA1C/RAC1/ACTR3/ARPC5L/RAB8B/MYL12A/ARPC1A/ARPC3	2.60431958302282
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/287	51/9376	3.20284211245474	ACTG1/ARF1/KDELR2/ATP6V0E1/ATP6V1D	2.80293207314518
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/287	93/9376	2.45895620246525	ACTG1/CSNK2B/RHOA/RAC1/ACP1/CSNK2A2/MYL12A	2.51251167548631
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/287	56/9376	2.91687406669985	RAB1A/ARF1/EEF1A1/CYCS/BNIP3	2.55651399234962
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/287	142/9376	2.07056976002356	UBC/UBE2L3/UBE2I/UBE2Q2/RNF7/UBE2N/ANAPC11/UBE2M/UBE2D2	2.28419272398783
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/287	98/9376	2.33349925335988	RAC1/LYN/ACTR3/ARPC5L/CFL1/ARPC1A/ARPC3	2.35801826875516
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/287	59/9376	2.76855843618969	GPX3/PRDX6/GSTO1/GPX1/IDH2	2.42145223764886
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/287	174/9376	1.87752813488726	CALR/PDIA6/HERPUD1/SSR2/BCAP31/DNAJA2/BAG1/RAD23A/UBXN1/UBE2D2	2.07617087341408
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/287	108/9376	2.11743450767841	SAP18/MAGOH/EEF1A1/UBE2I/SUMO1/RAN/EIF4A3	2.07543663636444
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/287	232/9376	1.68977532139853	ACTG1/EZR/RHOA/RAC1/BRK1/ACTR3/ARPC5L/CFL1/MYL12A/ARPC1A/PFN1/ARPC3	1.89039287106276
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/287	13/9376	5.02599839185205	XRCC6/XRCC5	2.58110871024489
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/287	71/9376	2.30063306669284	LDHA/PKM/PGAM1/SLC16A3/IDH2	1.95476390714333
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/287	142/9376	1.84050645335427	CALM1/ACTG1/CAV1/GSTO1/RHOA/RAC1/SUMO1/HMOX1	1.79332426237633
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/287	54/9376	2.41992515163247	LDHA/MDH2/ADI1/CDO1	1.85941494614387
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/287	35/9376	2.80019910403186	ALDOA/TPI1/AKR1B1	1.89594795807598
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/287	155/9376	1.68614139597617	ACTG1/ATP6V0E1/CALR/TUBA1C/TUBB4B/RAC1/RAB7A/ATP6V1D	1.53059043396982
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/287	61/9376	2.14222882275661	FTH1/HMOX1/ATP1B3/MT2A	1.59035887794124
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/287	20/9376	3.26689895470383	UGP2/NANS	1.80331081931533
NA	NA	hsa04517	IgSF CAM signaling	13/287	299/9376	1.42039084987123	ACTG1/DYNLL1/EZR/RHOA/TUBA1C/TUBB4B/RAC1/LYN/ACTR3/ARPC5L/MYL12A/ARPC1A/ARPC3	1.31276266235882
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/287	138/9376	1.6571226581831	ACTG1/RHOA/RAC1/ACTR3/ARPC5L/ARPC1A/ARPC3	1.38186475911897
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/287	42/9376	2.33349925335988	VDAC2/FTH1/HMOX1	1.53904762355201
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/287	194/9376	1.51557168001724	ACTG1/DYNLL1/KIF2A/TUBA1C/TUBB4B/TPM4/MYL12A/DCTN3/DYNLT1	1.28940636421148
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/287	116/9376	1.68977532139853	ACTG1/EZR/RHOA/RAC1/CD99/MYL12A	1.32831075294819
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/287	250/9376	1.43743554006969	CAV1/ARF1/CLTB/RHOA/ACTR3/ARPC5L/RAB7A/SNF8/ARPC1A/SNX6/ARPC3	1.2456968664382
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/287	70/9376	1.8667994026879	ACTG1/CAV1/RAC1/CYCS	1.29346485866645
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/287	71/9376	1.84050645335427	ATP6V0E1/RAC1/LYN/ATP6V1D	1.26322459486261
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/287	47/9376	2.08525465193862	LDHA/PKM/MDH2	1.32535302420848
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/287	76/9376	1.7194205024757	CALM1/ACTG1/EZR/ATP1B3	1.11896542429126
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/287	158/9376	1.44736029638777	EIF4B/RHOA/RPS6/ATP6V1D/RRAGA/EIF4E2/LAMTOR4	1.00771138199358
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/287	28/9376	2.33349925335988	ECHS1/TECR	1.25568577829213
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/287	28/9376	2.33349925335988	ATP6V0E1/ATP6V1D	1.25568577829213
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/287	52/9376	1.88474939694452	CYP11A1/CYP19A1/CYP2J2	1.1368138329893
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/287	52/9376	1.88474939694452	VDAC2/NPC2/VDAC1	1.1368138329893
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/287	30/9376	2.17793263646922	MDH2/IDH2	1.14825072586652
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/287	31/9376	2.10767674497021	GCSH/MDH2	1.097672457042
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/287	166/9376	1.3776079929474	CALM1/VDAC2/RHOA/VDAC1/ATP1B3/SLC25A6/SLC25A5	0.872235869260606
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/287	32/9376	2.0418118466899	UGP2/AKR1B1	1.04897805024294
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/287	32/9376	2.0418118466899	LDHA/ECHS1	1.04897805024294
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/287	34/9376	1.92170526747284	POLR2H/POLR2E	0.956709598877248
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/287	204/9376	1.2811368449819	ACTG1/CAV1/EIF4B/EZR/RHOA/RAC1/RPS6/PDCD4	0.721388745030698
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/287	36/9376	1.81494386372435	UGP2/AKR1B1	0.870510554572573
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/287	36/9376	1.81494386372435	SSBP1/RNASEH2C	0.870510554572573
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/287	63/9376	1.55566616890659	POLR2H/RAD23A/POLR2E	0.786335647302171
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/287	37/9376	1.76589132686694	UGP2/NANS	0.829442645476765
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/287	38/9376	1.7194205024757	QPRT/PNP	0.789616488981404
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/287	183/9376	1.24963347994136	CSNK2B/SNU13/CSNK2A2/NOP10/RAN/FBL/EIF6	0.605993939145395
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/287	66/9376	1.48495407031992	CYP11A1/COMT/CYP19A1	0.70253225883204
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/287	41/9376	1.59360924619699	GCSH/PGAM1	0.676867963283328
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/287	15/9376	2.17793263646922	ACP1	0.811285093813152
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/287	224/9376	1.16674962667994	VDAC2/CALR/VDAC1/RAN/SLC25A6/ANAPC11/SLC25A5/RANBP1	0.448848118041891
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/287	43/9376	1.51948788590876	ECHS1/ECI1	0.606691002627815
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/287	103/9376	1.26869862318595	SAP18/MAGOH/SSU72/EIF4A3	0.487239465862804
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/287	73/9376	1.34256121426185	PPIA/MLLT1/RAN	0.522103547168501
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/287	105/9376	1.24453293512527	CSNK2B/LYN/UBE2I/CSNK2A2	0.447751711485635
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/287	75/9376	1.30675958188153	GPX3/GPX1/ATP1B3	0.473949949698921
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/287	168/9376	1.16674962667994	PPIA/VDAC2/FTH1/VDAC1/SLC25A6/SLC25A5	0.387530055642047
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/287	17/9376	1.92170526747284	CDO1	0.675881160915309
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/287	46/9376	1.42039084987123	FTH1/HMOX1	0.507878564649802
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/287	169/9376	1.15984578273509	UBC/RAB1A/RAB7A/TAX1BP1/RRAGA/BNIP3	0.372609564171665
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/287	107/9376	1.22127063727246	LDHA/PKM/CALM1/PGAM1	0.40904187386025
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/287	233/9376	1.1216820445335	ENO1/ACTG1/PDLIM2/LMNA/PDLIM4/CSRP2/TPM4/ATP1B3	0.334217074758469
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/287	18/9376	1.81494386372435	PRDX1	0.614951635639477
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/287	78/9376	1.25649959796301	ENO1/LSM4/LSM7	0.404210651903178
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/287	78/9376	1.25649959796301	CALM1/RHOA/CFL1	0.404210651903178
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/287	79/9376	1.24059453976095	ATP6V0E1/CLTB/ATP6V1D	0.381589514040846
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/287	205/9376	1.11552647233789	PKM/PSMC1/RHOA/RAC1/LYN/YWHAB/RANBP1	0.297179351593177
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/287	19/9376	1.7194205024757	GCSH	0.557776009681398
NA	NA	hsa04519	Cadherin signaling	13/287	404/9376	1.05122986166212	KRT19/ACTG1/KRT18/KRT23/RHOA/RAC1/BRK1/ACTR3/ARPC5L/KRT8/YWHAB/ARPC1A/ARPC3	0.187041410154969
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/287	83/9376	1.18080685109777	PRDX1/IDH2/ECH1	0.293998080627473
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/287	117/9376	1.11688853152268	ACTG1/MORF4L2/MBD2/CDK2AP2	0.226074368444388
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/287	214/9376	1.0686118076134	CALM1/CALR/RAC1/GNG11/CYCS/CFL1/RNF7	0.180417698732971
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/287	85/9376	1.15302316048371	APRT/NME1/PNP	0.251827952912798
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/287	53/9376	1.2327920583788	CLTB/ATP1B3	0.301992938499571
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/287	250/9376	1.04540766550523	ATP6V0E1/CLTB/NPC2/LITAF/RAB7A/ATP6V1D/RRAGA/LAMTOR4	0.129308621387104
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/287	87/9376	1.12651688093236	RHOA/RAC1/CYCS	0.210664887755239
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/287	23/9376	1.42039084987123	FNTA	0.358682543185469
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/287	23/9376	1.42039084987123	SSBP1	0.358682543185469
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/287	23/9376	1.42039084987123	ATP1B3	0.358682543185469
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/287	57/9376	1.1462803349838	ECHS1/TECR	0.196837233740847
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/287	157/9376	1.04041367984198	CALM1/VDAC2/VDAC1/SLC25A6/SLC25A5	0.0907412693599029
Organismal Systems	Immune system	hsa04611	Platelet activation	4/287	126/9376	1.03711077927106	ACTG1/RHOA/LYN/MYL12A	0.0745217448713159
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/287	60/9376	1.08896631823461	CRH/LYN	0.122844308022378
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/287	195/9376	1.00519967837041	ACTG1/VDAC2/RAC1/VDAC1/SLC25A6/SLC25A5	0.0130381906662074
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/287	196/9376	1.00007110858281	CALM1/UBC/RAC1/LYN/GNG11/CYCS	0.000178771075611253
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/287	95/9376	1.03165230148542	FLT1/ATP6V0E1/ATP6V1D	0.0550983057720628
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/287	27/9376	1.20996257581623	ECHS1	0.194137632486723
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/287	27/9376	1.20996257581623	TECR	0.194137632486723
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/287	63/9376	1.03711077927106	PTGES3/CYP2J2	0.0525162953458501
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/287	98/9376	1.00007110858281	CALM1/CYP11A1/ATP1B3	0.000125740855796626
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/287	28/9376	1.16674962667994	AKR1B1	0.157019311581882
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/287	99/9376	0.989969380213283	KRT19/KRT18/KRT23	-0.0178283077630107
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/287	99/9376	0.989969380213283	ACTG1/LMNA/TPM4	-0.0178283077630107
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	6/287	203/9376	0.96558589794202	ACTG1/FLT1/CAV1/RHOA/RAC1/MYL12A	-0.0880840549893831
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/287	29/9376	1.12651688093236	CALM1	0.121249481195895
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/287	136/9376	0.960852633736421	EIF3H/CSNK2B/CYCS/CSNK2A2	-0.0817155207270484
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/287	30/9376	1.08896631823461	CYP2J2	0.0867245174535351
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/287	137/9376	0.953839110862433	ACTG1/LMNA/TUBA1C/CYCS	-0.0967142571405188
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/287	102/9376	0.960852633736421	RHOA/RAC1/ATP1B3	-0.0706378747091358
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/287	173/9376	0.944190449336368	ACTG1/VDAC1/CYCS/SLC25A6/SLC25A5	-0.131654407019937
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/287	103/9376	0.951523967389466	SERPINB9/RAB7A/PRDX1	-0.0879030787588316
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/287	31/9376	1.05383837248511	ALDOA	0.0533521163798191
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/287	31/9376	1.05383837248511	ECHS1	0.0533521163798191
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/287	139/9376	0.940114807109017	KRT19/CALM1/KRT18/KRT23	-0.126395006314451
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/287	105/9376	0.933399701343952	ACTG1/LMNA/TPM4	-0.121948389869951
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/287	69/9376	0.946927233247488	RAC1/LYN	-0.0786248720714979
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/287	32/9376	1.02090592334495	CYCS	0.021049726760728
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/287	212/9376	0.924594043784104	CALM1/ACTG1/FLT1/RHOA/RAC1/PFN1	-0.197332935583322
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/287	33/9376	0.989969380213283	IDH2	-0.0102567577695255
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/287	216/9376	0.907471931862176	CALM1/RHOA/RAC1/LYN/CYCS/CYP2J2	-0.244467520858263
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/287	181/9376	0.902458274780064	CALM1/CEBPB/RHOA/RAB7A/CYCS	-0.235462845583313
NA	NA	hsa04382	Cornified envelope formation	6/287	217/9376	0.903290033558664	KRT19/KRT18/KRT23/S100A9/KRT8/SPTLC3	-0.256121245356726
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/287	75/9376	0.871173054587689	GSTO1/CYCS	-0.199040316600804
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/287	36/9376	0.907471931862176	UGP2	-0.0988370653410189
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/287	76/9376	0.859710251237851	PLIN2/UBC	-0.218202536217897
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/287	37/9376	0.882945663433468	COMT	-0.126767147218446
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/287	37/9376	0.882945663433468	TFG	-0.126767147218446
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/287	38/9376	0.859710251237851	UGP2	-0.153978234532443
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/287	38/9376	0.859710251237851	ATP1B3	-0.153978234532443
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/287	78/9376	0.837666398642008	TPI1/IMPA2	-0.25581705137864
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/287	154/9376	0.848545183039957	UGP2/RFK/QPRT/NME1	-0.336743659176039
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/287	227/9376	0.863497521067092	CALM1/CALR/RHOA/RAC1/GNG11/CYCS	-0.369943318545013
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/287	39/9376	0.837666398642008	GCSH	-0.180511794034854
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/287	80/9376	0.816724738675958	RPS6/EIF4E2	-0.292529263843877
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/287	157/9376	0.832330943873588	CALR/CEBPB/RAC1/RAB7A	-0.37646913235259
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/287	120/9376	0.816724738675958	CALM1/RHOA/RAC1	-0.35904702478179
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/287	82/9376	0.796804623098496	GSTO1/NME1	-0.328388507333313
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/287	41/9376	0.796804623098496	SSBP1	-0.231695246987894
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/287	83/9376	0.787204567398514	CSNK2B/UBE2D2	-0.346012600580604
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/287	83/9376	0.787204567398514	POLR2H/POLR2E	-0.346012600580604
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/287	42/9376	0.777833084453293	ECHS1	-0.256412189615048
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/287	125/9376	0.78405574912892	RHOA/RAC1/SPTLC3	-0.431887711363291
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/287	86/9376	0.75974394295438	ACTG1/LMNA	-0.397726243979163
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/287	44/9376	0.742477035159962	TAF10	-0.304245015431701
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/287	44/9376	0.742477035159962	DYNLL1	-0.304245015431701
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/287	128/9376	0.765679442508711	APRT/NME1/PNP	-0.474307509919044
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/287	89/9376	0.734134596562659	TUBA1C/TUBB4B	-0.447803663761131
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/287	90/9376	0.725977545489741	CSNK2B/CSNK2A2	-0.464153470493459
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/287	47/9376	0.695084883979539	PKM	-0.372373590311462
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/287	91/9376	0.717999770264579	RAC1/LYN	-0.480338877793312
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/287	48/9376	0.680603948896632	ECHS1	-0.394207086558031
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/287	48/9376	0.680603948896632	ATP1B3	-0.394207086558031
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/287	133/9376	0.736894501061015	CALM1/COMT/GNG11	-0.543022473702921
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/287	93/9376	0.702558914990072	CALM1/ATP1B3	-0.512232099629846
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/287	93/9376	0.702558914990072	CYCS/CKS1B	-0.512232099629846
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/287	94/9376	0.695084883979539	CEBPB/S100A9	-0.527947374492452
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/287	254/9376	0.771708414496968	CALM1/FLT1/VDAC2/VDAC1/SLC25A6/SLC25A5	-0.655435957877261
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/287	178/9376	0.734134596562659	CSNK2B/RHOA/RAC1/CSNK2A2	-0.636346501040386
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/287	138/9376	0.710195424935616	CALM1/ANAPC11/YWHAB	-0.60943071179465
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/287	138/9376	0.710195424935616	CALM1/RPS6/EIF4E2	-0.60943071179465
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/287	97/9376	0.673587413340996	CALM1/GNG11	-0.574209947264178
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/287	180/9376	0.725977545489741	SRSF9/SRSF3/CALR/CYCS	-0.659616420191478
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/287	98/9376	0.666714072388537	CALM1/IMPA2	-0.589347391119044
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/287	140/9376	0.700049776007964	CALM1/RPS6/GNG11	-0.635389130518143
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/287	99/9376	0.659979586808855	CALM1/CYP2J2	-0.604348355433148
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/287	143/9376	0.685363417070734	SNRPD1/SNRPB/SSB	-0.673712108064842
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/287	184/9376	0.710195424935616	RHOA/RAC1/CFL1/MYL12A	-0.705468579649133
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/287	55/9376	0.59398162812797	SPTLC3	-0.536616856656638
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/287	226/9376	0.72276525546545	CALM1/CRH/RHOA/RAC1/ATP1B3	-0.749652277661402
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/287	105/9376	0.622266467562635	CALM1/RHOA	-0.691648491225537
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/287	59/9376	0.553711687237938	NME1	-0.611043328544177
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/287	60/9376	0.544483159117305	RAC1	-0.628975686767319
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/287	193/9376	0.677077503565561	RHOA/RAC1/LYN/GNG11	-0.805477101232583
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/287	110/9376	0.59398162812797	INHBA/RHOA	-0.761139770316755
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/287	154/9376	0.636408887279967	CALM1/TPM4/ATP1B3	-0.808406125329989
NA	NA	hsa04518	Integrin signaling	3/287	154/9376	0.636408887279967	ACTG1/FLT1/RAC1	-0.808406125329989
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/287	154/9376	0.636408887279967	CALM1/ACTG1/RHOA	-0.808406125329989
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/287	238/9376	0.68632330981173	CALM1/FLT1/RHOA/RAC1/GNG11	-0.87099103182507
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/287	63/9376	0.518555389635529	ECHS1	-0.68130305661047
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/287	156/9376	0.628249798981506	CYCS/YWHAB/EIF3E	-0.831987086498243
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/287	65/9376	0.502599839185205	AKR1B1	-0.715044336543554
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/287	65/9376	0.502599839185205	CYP11A1	-0.715044336543554
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/287	201/9376	0.650129145214693	FLT1/CEBPB/MLLT1/CEBPA	-0.89098684751204
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/287	115/9376	0.568156339948493	GNG11/CYP2J2	-0.827970876577029
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/287	115/9376	0.568156339948493	NACA/RHOA	-0.827970876577029
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/287	67/9376	0.48759685891102	CALM1	-0.747939043144191
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/287	68/9376	0.480426316868211	CEBPA	-0.764085484648422
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/287	69/9376	0.473463616623744	CALM1	-0.780039525299248
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/287	69/9376	0.473463616623744	CALM1	-0.780039525299248
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/287	70/9376	0.466699850671976	LEP	-0.795806965415891
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/287	70/9376	0.466699850671976	GSTO1	-0.795806965415891
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/287	70/9376	0.466699850671976	RAC1	-0.795806965415891
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/287	122/9376	0.535557205689153	ACTG1/ATP1B3	-0.917520828588521
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/287	170/9376	0.576511580241853	ACTG1/GSTO1/HMOX1	-0.990145571420481
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/287	73/9376	0.44752040475395	GSTO1	-0.84204382868544
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/287	75/9376	0.435586527293844	CYCS	-0.872030582900529
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/287	76/9376	0.429855125618925	CALM1	-0.886786516472473
NA	NA	hsa04081	Hormone signaling	4/287	219/9376	0.596693873005266	CRH/LEP/RHOA/GNG11	-1.07312127503708
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/287	77/9376	0.424272591519978	RAC1	-0.901389882006255
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/287	78/9376	0.418833199321004	EEF1A1	-0.915844754660457
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/287	79/9376	0.41353151325365	GSTO1	-0.930155044583159
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/287	134/9376	0.48759685891102	CALM1/RHOA	-1.06157268499711
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/287	82/9376	0.398402311549248	CALR	-0.972255225182988
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/287	187/9376	0.524101436583503	VDAC2/RHOA/VDAC1	-1.16807198019938
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/287	362/9376	0.631720792346045	FLT1/EIF4B/RAC1/RPS6/GNG11/YWHAB/EIF4E2	-1.26981731095987
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/287	86/9376	0.37987197147719	ATP1B3	-1.02657637273947
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/287	191/9376	0.513125490267618	CALM1/CRH/GNG11	-1.20798815513491
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/287	89/9376	0.36706729828133	GNG11	-1.06606417788635
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/287	90/9376	0.36298877274487	EIF4E2	-1.07900271312509
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/287	90/9376	0.36298877274487	ATP1B3	-1.07900271312509
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/287	91/9376	0.358999885132289	GNG11	-1.09183342201464
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/287	93/9376	0.351279457495036	CALM1	-1.11718085465308
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/287	149/9376	0.438509926805884	ARF1/RHOA	-1.22764695612593
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/287	155/9376	0.421535348994043	CYP11A1/CRH	-1.29039359294123
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/287	99/9376	0.329989793404428	RAC1	-1.19086840310329
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/287	157/9376	0.416165471936794	ACTG1/YWHAB	-1.31088993577757
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/287	158/9376	0.41353151325365	ANAPC11/YWHAB	-1.32106262904157
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/287	101/9376	0.323455342049884	CALM1	-1.2146991617096
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/287	101/9376	0.323455342049884	RAC1	-1.2146991617096
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/287	103/9376	0.317174655796489	ATP1B3	-1.2381881680021
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/287	103/9376	0.317174655796489	CALR	-1.2381881680021
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/287	163/9376	0.400846497509673	CYCS/YWHAB	-1.37119715630137
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/287	109/9376	0.299715500431544	RAC1	-1.30673256989651
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/287	110/9376	0.296990814063985	ANAPC11	-1.31789171964504
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/287	112/9376	0.291687406669985	CYCS	-1.33999518042127
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/287	323/9376	0.505711912492853	EZR/RHOA/PDCD4/UBE2I/HMOX1	-1.6063999420345
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/287	115/9376	0.284078169974246	GNG11	-1.37263199625613
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/287	116/9376	0.281629220233089	GNG11	-1.38337745895789
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/287	119/9376	0.274529323924692	CEBPB	-1.41522908832841
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/287	333/9376	0.490525368574149	PKM/ATP6V0E1/PSMC1/BCAP31/ATP6V1D	-1.68211990502619
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/287	122/9376	0.267778602844576	LEP	-1.44652558131549
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/287	122/9376	0.267778602844576	RHOA	-1.44652558131549
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/287	130/9376	0.251299919592603	GNG11	-1.5274645727678
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/287	133/9376	0.245631500353672	BNIP3	-1.55693837800215
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/287	133/9376	0.245631500353672	RAC1	-1.55693837800215
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/287	142/9376	0.230063306669284	RAC1	-1.6427549689042
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/287	144/9376	0.226867982965544	INHBA	-1.66132860046178
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/287	217/9376	0.301096677852888	PTGES3/GSTO1	-1.85093631855259
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/287	160/9376	0.20418118466899	CD99	-1.80414523645222
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/287	168/9376	0.194458271113323	LEP	-1.87209793048969
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/287	298/9376	0.328882445104413	INHBA/LEP/INHA	-2.09208910020158
NA	NA	hsa04082	Neuroactive ligand signaling	1/287	199/9376	0.164165776618283	GNG11	-2.11770204814263
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	2/287	300/9376	0.217793263646922	FLT1/RAC1	-2.44682816183559
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/287	370/9376	0.26488369903004	CRH/LEP/NPB	-2.56365440095264
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/287	449/9376	0.0727594421983036	CALM1	-3.57792602832644