ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 26/219 175/18639 0.148571428571429 12.6448532289628 2.34628702759473e-21 1.13794920838345e-18 GO:0045296 cadherin binding 23/219 334/18639 0.0688622754491018 5.8608399639078 1.03992934057461e-11 1.92751396563598e-09 GO:0019843 rRNA binding 12/219 65/18639 0.184615384615385 15.7125395152792 1.19227667977483e-11 1.92751396563598e-09 GO:0042605 peptide antigen binding 8/219 45/18639 0.177777777777778 15.1305936073059 4.74094684062144e-08 5.7483980442535e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/219 68/18639 0.132352941176471 11.2645044319097 9.78453402291801e-08 9.49099800223047e-06 GO:0008135 translation factor activity, RNA binding 9/219 83/18639 0.108433734939759 9.22875061891401 5.60405917489245e-07 4.30483354543561e-05 GO:0180051 translation factor activity 9/219 84/18639 0.107142857142857 9.11888454011742 6.21316181815449e-07 4.30483354543561e-05 GO:0009055 electron transfer activity 10/219 116/18639 0.0862068965517241 7.33703353802551 1.12554133525664e-06 6.82359434499335e-05 GO:0015399 primary active transmembrane transporter activity 11/219 166/18639 0.0662650602409639 5.6397920448919 4.39201711501385e-06 0.00023668092230908 GO:0022853 active monoatomic ion transmembrane transporter activity 9/219 118/18639 0.076271186440678 6.49140933364291 1.06904494209431e-05 0.00051848679691574 GO:0023026 MHC class II protein complex binding 5/219 27/18639 0.185185185185185 15.7610350076103 1.39879704377861e-05 0.000616742332938753 GO:0003743 translation initiation factor activity 6/219 51/18639 0.117647058823529 10.0128928283642 2.84610074186576e-05 0.00115029904983741 GO:0005525 GTP binding 15/219 378/18639 0.0396825396825397 3.37736464448793 4.31920129466065e-05 0.00161139432916186 GO:0023023 MHC protein complex binding 5/219 37/18639 0.135135135135135 11.5012958163643 6.86443382618407e-05 0.00223249133460517 GO:0015078 proton transmembrane transporter activity 10/219 185/18639 0.0540540540540541 4.60051832654572 6.90461237506752e-05 0.00223249133460517 GO:0019001 guanyl nucleotide binding 15/219 400/18639 0.0375 3.1916095890411 8.16925446658826e-05 0.00233064024487959 GO:0032561 guanyl ribonucleotide binding 15/219 400/18639 0.0375 3.1916095890411 8.16925446658826e-05 0.00233064024487959 GO:0004857 enzyme inhibitor activity 15/219 416/18639 0.0360576923076923 3.06885537407798 0.000126045187982118 0.00339621756507374 GO:0035035 histone acetyltransferase binding 4/219 24/18639 0.166666666666667 14.1849315068493 0.000163816935694779 0.00418164283220884 GO:0042277 peptide binding 11/219 249/18639 0.0441767068273092 3.75986136326126 0.000182442336579641 0.00442422666205628 GO:0042608 T cell receptor binding 3/219 11/18639 0.272727272727273 23.2117061021171 0.000246246636614415 0.00568712470276149 GO:0048306 calcium-dependent protein binding 6/219 80/18639 0.075 6.38321917808219 0.000357971112042126 0.00755605898669421 GO:0005200 structural constituent of cytoskeleton 7/219 112/18639 0.0625 5.31934931506849 0.000358328570503024 0.00755605898669421 GO:0003924 GTPase activity 12/219 331/18639 0.0362537764350453 3.08554401357447 0.000569258538620339 0.011503766301286 GO:0004129 cytochrome-c oxidase activity 3/219 15/18639 0.2 17.0219178082192 0.000655858122301029 0.01272364757264 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/219 16/18639 0.1875 15.9580479452055 0.000800239243053635 0.0149275397261928 GO:0003823 antigen binding 8/219 174/18639 0.0459770114942529 3.9130845536136 0.00106856449336535 0.0190312058005322 GO:0003746 translation elongation factor activity 3/219 18/18639 0.166666666666667 14.1849315068493 0.00114602731907759 0.0190312058005322 GO:0043021 ribonucleoprotein complex binding 8/219 177/18639 0.0451977401129944 3.8467610866032 0.00119248400269209 0.0190312058005322 GO:0061791 GTPase motor activity 4/219 40/18639 0.1 8.51095890410959 0.00121642758725051 0.0190312058005322 GO:1990606 membrane scission GTPase motor activity 4/219 40/18639 0.1 8.51095890410959 0.00121642758725051 0.0190312058005322 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/219 41/18639 0.0975609756097561 8.30337454059472 0.00133565262675507 0.0202434851242565 GO:0061135 endopeptidase regulator activity 8/219 184/18639 0.0434782608695652 3.70041691483026 0.00152643247658287 0.0220522874076675 GO:0044389 ubiquitin-like protein ligase binding 11/219 322/18639 0.0341614906832298 2.90747043308092 0.00154593355022823 0.0220522874076675 GO:0003954 NADH dehydrogenase activity 4/219 44/18639 0.0909090909090909 7.73723536737235 0.0017419683433815 0.024138704186858 GO:0019003 GDP binding 5/219 75/18639 0.0666666666666667 5.67397260273973 0.00189463960852797 0.025525005837113 GO:0140297 DNA-binding transcription factor binding 14/219 488/18639 0.0286885245901639 2.44166853806423 0.00195983980582604 0.0256897920493413 GO:0043022 ribosome binding 6/219 112/18639 0.0535714285714286 4.55944227005871 0.0020902774881153 0.0266785416246295 GO:0004602 glutathione peroxidase activity 3/219 23/18639 0.130434782608696 11.1012507444908 0.00238200803724135 0.0296224076426168 GO:0004866 endopeptidase inhibitor activity 7/219 161/18639 0.0434782608695652 3.70041691483026 0.00297806420695169 0.0361090285092893 GO:0031625 ubiquitin protein ligase binding 10/219 302/18639 0.033112582781457 2.81819831261907 0.00313008882032729 0.037026660435579 GO:0070412 R-SMAD binding 3/219 26/18639 0.115384615384615 9.82033719704953 0.00340765589252723 0.0393503120922788 GO:0003925 G protein activity 4/219 54/18639 0.0740740740740741 6.30441400304414 0.00370433916136577 0.0417382151664531 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/219 88/18639 0.0568181818181818 4.83577210460772 0.00380432028519086 0.0417382151664531 GO:0030414 peptidase inhibitor activity 7/219 169/18639 0.0414201183431953 3.52524925022291 0.00389148405381433 0.0417382151664531 GO:0140313 molecular sequestering activity 4/219 55/18639 0.0727272727272727 6.18978829389788 0.00395867607764297 0.0417382151664531 GO:0004601 peroxidase activity 4/219 57/18639 0.0701754385964912 5.97260273972603 0.00450227240245886 0.0464596194721818 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4/219 58/18639 0.0689655172413793 5.86962683042041 0.00479200684922985 0.0484192358724266 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/219 59/18639 0.0677966101694915 5.77014162990481 0.00509400962358389 0.0504202993354732 GO:0061134 peptidase regulator activity 8/219 226/18639 0.0353982300884956 3.01272881561401 0.00536878036639296 0.0518208764789335 GO:0002020 protease binding 6/219 136/18639 0.0441176470588235 3.75483481063658 0.00544920556788785 0.0518208764789335 GO:0032395 MHC class II receptor activity 2/219 10/18639 0.2 17.0219178082192 0.00581174304068716 0.053182931598741 GO:0070513 death domain binding 2/219 10/18639 0.2 17.0219178082192 0.00581174304068716 0.053182931598741 GO:0019956 chemokine binding 3/219 33/18639 0.0909090909090909 7.73723536737235 0.0067328804000976 0.0593717635281334 GO:0071889 14-3-3 protein binding 3/219 33/18639 0.0909090909090909 7.73723536737235 0.0067328804000976 0.0593717635281334 GO:1990948 ubiquitin ligase inhibitor activity 2/219 11/18639 0.181818181818182 15.4744707347447 0.00704852001937 0.0610452180249009 GO:0004859 phospholipase inhibitor activity 2/219 12/18639 0.166666666666667 14.1849315068493 0.00839312658207037 0.0695857562805437 GO:0035259 nuclear glucocorticoid receptor binding 2/219 12/18639 0.166666666666667 14.1849315068493 0.00839312658207037 0.0695857562805437 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 10/219 349/18639 0.0286532951289398 2.4386701730973 0.0084650713825816 0.0695857562805437 GO:0043531 ADP binding 3/219 38/18639 0.0789473684210526 6.71917808219178 0.0099734712154274 0.0806188923247048 GO:0044548 S100 protein binding 2/219 14/18639 0.142857142857143 12.1585127201566 0.0113951521031474 0.0890780958109096 GO:0098847 sequence-specific single stranded DNA binding 2/219 14/18639 0.142857142857143 12.1585127201566 0.0113951521031474 0.0890780958109096 GO:0017124 SH3 domain binding 5/219 115/18639 0.0434782608695652 3.70041691483026 0.0115709691465718 0.0890780958109096 GO:0003725 double-stranded RNA binding 4/219 75/18639 0.0533333333333333 4.53917808219178 0.0117687759000005 0.0891852548671916 GO:0031386 protein tag activity 2/219 15/18639 0.133333333333333 11.3479452054795 0.0130473511771237 0.0944472435955971 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/219 15/18639 0.133333333333333 11.3479452054795 0.0130473511771237 0.0944472435955971 GO:0141047 molecular tag activity 2/219 15/18639 0.133333333333333 11.3479452054795 0.0130473511771237 0.0944472435955971 GO:0043023 ribosomal large subunit binding 2/219 16/18639 0.125 10.638698630137 0.0147969385962766 0.103063773750088 GO:0055102 lipase inhibitor activity 2/219 16/18639 0.125 10.638698630137 0.0147969385962766 0.103063773750088 GO:0001046 core promoter sequence-specific DNA binding 3/219 44/18639 0.0681818181818182 5.80292652552926 0.0148751838402189 0.103063773750088 GO:0043495 protein-membrane adaptor activity 3/219 47/18639 0.0638297872340425 5.43252696006995 0.0177524053658676 0.121266431020363 GO:0098641 cadherin binding involved in cell-cell adhesion 2/219 18/18639 0.111111111111111 9.45662100456621 0.0185783434361908 0.123723637805044 GO:0016209 antioxidant activity 4/219 86/18639 0.0465116279069767 3.95858553679516 0.0186223207417901 0.123723637805044 GO:0031072 heat shock protein binding 5/219 131/18639 0.0381679389312977 3.24845759698839 0.0193309245309975 0.126695924290997 GO:0022804 active transmembrane transporter activity 11/219 457/18639 0.0240700218818381 2.04858967057342 0.0196136615790301 0.126835011544395 GO:0070003 threonine-type peptidase activity 2/219 19/18639 0.105263157894737 8.95890410958904 0.0206053044310154 0.131494376961085 GO:0044325 transmembrane transporter binding 5/219 136/18639 0.0367647058823529 3.12902900886382 0.0223194307949809 0.14058342773462 GO:0043024 ribosomal small subunit binding 2/219 20/18639 0.1 8.51095890410959 0.0227199395323623 0.141271418887124 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/219 21/18639 0.0952380952380952 8.10567514677104 0.0249199285156015 0.151077066625834 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/219 21/18639 0.0952380952380952 8.10567514677104 0.0249199285156015 0.151077066625834 GO:0046982 protein heterodimerization activity 9/219 369/18639 0.024390243902439 2.07584363514868 0.0307928419475114 0.184376893142507 GO:0019957 C-C chemokine binding 2/219 24/18639 0.0833333333333333 7.09246575342466 0.0320094422994746 0.187043126689701 GO:0048027 mRNA 5'-UTR binding 2/219 24/18639 0.0833333333333333 7.09246575342466 0.0320094422994746 0.187043126689701 GO:0003774 cytoskeletal motor activity 5/219 153/18639 0.0326797385620915 2.78135911899006 0.0346573012890361 0.200104656252173 GO:0008320 protein transmembrane transporter activity 2/219 27/18639 0.0740740740740741 6.30441400304414 0.0397875688977487 0.227023187240095 GO:0051019 mitogen-activated protein kinase binding 2/219 28/18639 0.0714285714285714 6.07925636007828 0.0425235134521119 0.239812837491561 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/219 30/18639 0.0666666666666667 5.67397260273973 0.0481981851255499 0.268691032021744 GO:0005164 tumor necrosis factor receptor binding 2/219 31/18639 0.0645161290322581 5.4909412284578 0.05113301800269 0.281812656037553 GO:0022884 macromolecule transmembrane transporter activity 2/219 32/18639 0.0625 5.31934931506849 0.0541303128127144 0.288313565170391 GO:0051059 NF-kappaB binding 2/219 32/18639 0.0625 5.31934931506849 0.0541303128127144 0.288313565170391 GO:0051082 unfolded protein binding 4/219 121/18639 0.0330578512396694 2.81354013358995 0.0545307803515982 0.288313565170391 GO:0000287 magnesium ion binding 6/219 230/18639 0.0260869565217391 2.22025014889815 0.0546904082385072 0.288313565170391 GO:0019239 deaminase activity 2/219 33/18639 0.0606060606060606 5.15815691158157 0.0571882116780445 0.291960870145806 GO:0140311 protein sequestering activity 2/219 33/18639 0.0606060606060606 5.15815691158157 0.0571882116780445 0.291960870145806 GO:0140416 transcription regulator inhibitor activity 2/219 33/18639 0.0606060606060606 5.15815691158157 0.0571882116780445 0.291960870145806 GO:0098631 cell adhesion mediator activity 3/219 76/18639 0.0394736842105263 3.35958904109589 0.0602614886420715 0.298914136036948 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/219 34/18639 0.0588235294117647 5.00644641418211 0.0603048914012191 0.298914136036948 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 10/219 484/18639 0.0206611570247934 1.75846258349372 0.0603991450136514 0.298914136036948 GO:0001216 DNA-binding transcription activator activity 10/219 491/18639 0.0203665987780041 1.73339285216081 0.0651708582502761 0.319271376276605 GO:0046332 SMAD binding 3/219 79/18639 0.0379746835443038 3.23200971042136 0.0661100297688816 0.320327953487355 GO:0055106 ubiquitin-protein transferase regulator activity 2/219 36/18639 0.0555555555555556 4.72831050228311 0.0667074707262327 0.320327953487355 GO:0003712 transcription coregulator activity 10/219 495/18639 0.0202020202020202 1.71938563719386 0.0680036901018866 0.32073758284067 GO:0000049 tRNA binding 3/219 80/18639 0.0375 3.1916095890411 0.0681154041909051 0.32073758284067 GO:0001618 virus receptor activity 3/219 81/18639 0.037037037037037 3.15220700152207 0.070148260350163 0.327133714132972 GO:0140272 exogenous protein binding 3/219 82/18639 0.0365853658536585 3.11376545272302 0.0722083214255475 0.3335336751561 GO:0004860 protein kinase inhibitor activity 3/219 84/18639 0.0357142857142857 3.03962818003914 0.0764089274701997 0.349606885123083 GO:0003779 actin binding 9/219 443/18639 0.0203160270880361 1.72908871641053 0.0786335508250472 0.356423104206989 GO:0015036 disulfide oxidoreductase activity 2/219 40/18639 0.05 4.25547945205479 0.0801415009029923 0.356592916861938 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/219 40/18639 0.05 4.25547945205479 0.0801415009029923 0.356592916861938 GO:0001530 lipopolysaccharide binding 2/219 41/18639 0.0487804878048781 4.15168727029736 0.0836213962689995 0.358905992835971 GO:0017080 sodium channel regulator activity 2/219 41/18639 0.0487804878048781 4.15168727029736 0.0836213962689995 0.358905992835971 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/219 41/18639 0.0487804878048781 4.15168727029736 0.0836213962689995 0.358905992835971 GO:0140318 protein transporter activity 2/219 41/18639 0.0487804878048781 4.15168727029736 0.0836213962689995 0.358905992835971 GO:0035198 miRNA binding 2/219 42/18639 0.0476190476190476 4.05283757338552 0.0871466707953271 0.365281478075109 GO:0051879 Hsp90 protein binding 2/219 42/18639 0.0476190476190476 4.05283757338552 0.0871466707953271 0.365281478075109 GO:0003727 single-stranded RNA binding 3/219 89/18639 0.0337078651685393 2.86886255194705 0.0873662916633249 0.365281478075109 GO:0019210 kinase inhibitor activity 3/219 90/18639 0.0333333333333333 2.83698630136986 0.0896335029490563 0.370223600119814 GO:0019955 cytokine binding 4/219 144/18639 0.0277777777777778 2.36415525114155 0.0900750202353363 0.370223600119814 GO:0003714 transcription corepressor activity 5/219 204/18639 0.0245098039215686 2.08601933924255 0.0931834244213891 0.379781183566166 GO:0004867 serine-type endopeptidase inhibitor activity 3/219 95/18639 0.0315789473684211 2.68767123287671 0.101331122312447 0.396380578222371 GO:0004382 GDP phosphatase activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0004955 prostaglandin receptor activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0005522 profilin binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0016868 intramolecular phosphotransferase activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0030957 Tat protein binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0031996 thioesterase binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0032356 oxidized DNA binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0035256 G protein-coupled glutamate receptor binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0097177 mitochondrial ribosome binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0098505 G-rich strand telomeric DNA binding 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0141109 transporter activator activity 1/219 10/18639 0.1 8.51095890410959 0.111499441829139 0.396380578222371 GO:0016763 pentosyltransferase activity 2/219 49/18639 0.0408163265306122 3.47386077718759 0.112968929206409 0.396380578222371 GO:0035254 glutamate receptor binding 2/219 49/18639 0.0408163265306122 3.47386077718759 0.112968929206409 0.396380578222371 GO:0043130 ubiquitin binding 3/219 100/18639 0.03 2.55328767123288 0.113601856438989 0.396380578222371 GO:0032813 tumor necrosis factor receptor superfamily binding 2/219 50/18639 0.04 3.40438356164384 0.116804397278803 0.396933550301384 GO:0005048 signal sequence binding 2/219 51/18639 0.0392156862745098 3.33763094278807 0.12067245285622 0.396933550301384 GO:0030544 Hsp70 protein binding 2/219 51/18639 0.0392156862745098 3.33763094278807 0.12067245285622 0.396933550301384 GO:0004954 prostanoid receptor activity 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0005536 D-glucose binding 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0019215 intermediate filament binding 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0034511 U3 snoRNA binding 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0070990 snRNP binding 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/219 11/18639 0.0909090909090909 7.73723536737235 0.121944534010116 0.396933550301384 GO:0019207 kinase regulator activity 6/219 287/18639 0.0209059233449477 1.77929454441315 0.123165861885946 0.398236286764558 GO:0030159 signaling receptor complex adaptor activity 2/219 52/18639 0.0384615384615385 3.27344573234984 0.124571809967958 0.39902369403147 GO:0005544 calcium-dependent phospholipid binding 2/219 53/18639 0.0377358490566038 3.21168260532437 0.12850120811089 0.39902369403147 GO:0140296 general transcription initiation factor binding 2/219 53/18639 0.0377358490566038 3.21168260532437 0.12850120811089 0.39902369403147 GO:0004000 adenosine deaminase activity 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0004126 cytidine deaminase activity 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0005049 nuclear export signal receptor activity 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0005165 neurotrophin receptor binding 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0035497 cAMP response element binding 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0043047 single-stranded telomeric DNA binding 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0097371 MDM2/MDM4 family protein binding 1/219 12/18639 0.0833333333333333 7.09246575342466 0.132267389230847 0.39902369403147 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/219 54/18639 0.037037037037037 3.15220700152207 0.132459411833127 0.39902369403147 GO:0016247 channel regulator activity 4/219 168/18639 0.0238095238095238 2.02641878669276 0.136278272874531 0.405987282252033 GO:0098632 cell-cell adhesion mediator activity 2/219 55/18639 0.0363636363636364 3.09489414694894 0.136445210323879 0.405987282252033 GO:0141108 transporter regulator activity 4/219 170/18639 0.0235294117647059 2.00257856567284 0.140498737692811 0.413758528671855 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/219 13/18639 0.0769230769230769 6.54689146469968 0.142469431522061 0.413758528671855 GO:0030955 potassium ion binding 1/219 13/18639 0.0769230769230769 6.54689146469968 0.142469431522061 0.413758528671855 GO:0043560 insulin receptor substrate binding 1/219 13/18639 0.0769230769230769 6.54689146469968 0.142469431522061 0.413758528671855 GO:0061980 regulatory RNA binding 2/219 58/18639 0.0344827586206897 2.9348134152102 0.148556427473164 0.422826296421048 GO:0008191 metalloendopeptidase inhibitor activity 1/219 14/18639 0.0714285714285714 6.07925636007828 0.152552068400439 0.422826296421048 GO:0043176 amine binding 1/219 14/18639 0.0714285714285714 6.07925636007828 0.152552068400439 0.422826296421048 GO:0071933 Arp2/3 complex binding 1/219 14/18639 0.0714285714285714 6.07925636007828 0.152552068400439 0.422826296421048 GO:1990825 sequence-specific mRNA binding 1/219 14/18639 0.0714285714285714 6.07925636007828 0.152552068400439 0.422826296421048 GO:0001786 phosphatidylserine binding 2/219 59/18639 0.0338983050847458 2.8850708149524 0.152640975736759 0.422826296421048 GO:0004879 nuclear receptor activity 2/219 59/18639 0.0338983050847458 2.8850708149524 0.152640975736759 0.422826296421048 GO:0031593 polyubiquitin modification-dependent protein binding 2/219 59/18639 0.0338983050847458 2.8850708149524 0.152640975736759 0.422826296421048 GO:0001221 transcription coregulator binding 3/219 115/18639 0.0260869565217391 2.22025014889815 0.15343799622702 0.422826296421048 GO:0098531 ligand-modulated transcription factor activity 2/219 60/18639 0.0333333333333333 2.83698630136986 0.156747420399262 0.429505643466904 GO:0004953 icosanoid receptor activity 1/219 15/18639 0.0666666666666667 5.67397260273973 0.162516691059247 0.433080193207335 GO:0005523 tropomyosin binding 1/219 15/18639 0.0666666666666667 5.67397260273973 0.162516691059247 0.433080193207335 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/219 15/18639 0.0666666666666667 5.67397260273973 0.162516691059247 0.433080193207335 GO:0042809 nuclear vitamin D receptor binding 1/219 15/18639 0.0666666666666667 5.67397260273973 0.162516691059247 0.433080193207335 GO:0061578 K63-linked deubiquitinase activity 1/219 15/18639 0.0666666666666667 5.67397260273973 0.162516691059247 0.433080193207335 GO:0032182 ubiquitin-like protein binding 3/219 120/18639 0.025 2.1277397260274 0.167584281021492 0.444144132761877 GO:0005507 copper ion binding 2/219 63/18639 0.0317460317460317 2.70189171559035 0.16918752968836 0.444664187021477 GO:0003697 single-stranded DNA binding 3/219 121/18639 0.0247933884297521 2.11015510019246 0.170458522563947 0.444664187021477 GO:0005521 lamin binding 1/219 16/18639 0.0625 5.31934931506849 0.172364674556779 0.444664187021477 GO:0008296 3'-5'-DNA exonuclease activity 1/219 16/18639 0.0625 5.31934931506849 0.172364674556779 0.444664187021477 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/219 16/18639 0.0625 5.31934931506849 0.172364674556779 0.444664187021477 GO:0004536 DNA nuclease activity 2/219 64/18639 0.03125 2.65967465753425 0.173371065087741 0.444894003002934 GO:0019887 protein kinase regulator activity 5/219 255/18639 0.0196078431372549 1.66881547139404 0.181904979007398 0.450598103730995 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:0008429 phosphatidylethanolamine binding 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:0017110 nucleoside diphosphate phosphatase activity 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:0031489 myosin V binding 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:0046965 nuclear retinoid X receptor binding 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:0048038 quinone binding 1/219 17/18639 0.0588235294117647 5.00644641418211 0.182097378002629 0.450598103730995 GO:1990841 promoter-specific chromatin binding 2/219 68/18639 0.0294117647058824 2.50322320709106 0.190263215289576 0.46491165099894 GO:0017075 syntaxin-1 binding 1/219 18/18639 0.0555555555555556 4.72831050228311 0.191716144741831 0.46491165099894 GO:0035615 clathrin adaptor activity 1/219 18/18639 0.0555555555555556 4.72831050228311 0.191716144741831 0.46491165099894 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/219 18/18639 0.0555555555555556 4.72831050228311 0.191716144741831 0.46491165099894 GO:0035591 signaling adaptor activity 3/219 129/18639 0.0232558139534884 1.97929276839758 0.193936586540655 0.467956440160288 GO:0031420 alkali metal ion binding 1/219 19/18639 0.0526315789473684 4.47945205479452 0.201222302536877 0.483132756091015 GO:0051087 protein-folding chaperone binding 3/219 134/18639 0.0223880597014925 1.90543856062155 0.208998077487534 0.49587050688158 GO:0000339 RNA cap binding 1/219 20/18639 0.05 4.25547945205479 0.21061716374764 0.49587050688158 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/219 20/18639 0.05 4.25547945205479 0.21061716374764 0.49587050688158 GO:0042288 MHC class I protein binding 1/219 20/18639 0.05 4.25547945205479 0.21061716374764 0.49587050688158 GO:0048029 monosaccharide binding 2/219 74/18639 0.027027027027027 2.30025916327286 0.215975251403364 0.506009574264248 GO:0016922 nuclear receptor binding 3/219 137/18639 0.0218978102189781 1.86371362863714 0.218157712862109 0.506009574264248 GO:0030695 GTPase regulator activity 8/219 489/18639 0.016359918200409 1.39238591478276 0.218580987188855 0.506009574264248 GO:0140312 cargo adaptor activity 1/219 21/18639 0.0476190476190476 4.05283757338552 0.219902025509242 0.506009574264248 GO:0060589 nucleoside-triphosphatase regulator activity 8/219 490/18639 0.0163265306122449 1.38954431087503 0.220140247772693 0.506009574264248 GO:0017022 myosin binding 2/219 76/18639 0.0263157894736842 2.23972602739726 0.224618421399632 0.513558155206071 GO:0034062 5'-3' RNA polymerase activity 1/219 22/18639 0.0454545454545455 3.86861768368618 0.229078169907861 0.513558155206071 GO:0061133 endopeptidase activator activity 1/219 22/18639 0.0454545454545455 3.86861768368618 0.229078169907861 0.513558155206071 GO:0097747 RNA polymerase activity 1/219 22/18639 0.0454545454545455 3.86861768368618 0.229078169907861 0.513558155206071 GO:0140517 protein-RNA adaptor activity 1/219 22/18639 0.0454545454545455 3.86861768368618 0.229078169907861 0.513558155206071 GO:0016835 carbon-oxygen lyase activity 2/219 79/18639 0.0253164556962025 2.15467314028091 0.23762961167098 0.513558155206071 GO:0005212 structural constituent of eye lens 1/219 23/18639 0.0434782608695652 3.70041691483026 0.238146864154526 0.513558155206071 GO:0016493 C-C chemokine receptor activity 1/219 23/18639 0.0434782608695652 3.70041691483026 0.238146864154526 0.513558155206071 GO:0017134 fibroblast growth factor binding 1/219 23/18639 0.0434782608695652 3.70041691483026 0.238146864154526 0.513558155206071 GO:0099186 structural constituent of postsynapse 1/219 23/18639 0.0434782608695652 3.70041691483026 0.238146864154526 0.513558155206071 GO:0033192 calmodulin-dependent protein phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0140791 histone H2AXS140 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/219 81/18639 0.0246913580246914 2.10147133434805 0.246326202456085 0.513558155206071 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/219 24/18639 0.0416666666666667 3.54623287671233 0.24710936075692 0.513558155206071 GO:0015149 hexose transmembrane transporter activity 1/219 24/18639 0.0416666666666667 3.54623287671233 0.24710936075692 0.513558155206071 GO:0055056 D-glucose transmembrane transporter activity 1/219 24/18639 0.0416666666666667 3.54623287671233 0.24710936075692 0.513558155206071 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/219 82/18639 0.024390243902439 2.07584363514868 0.250679149481849 0.513558155206071 GO:0033549 MAP kinase phosphatase activity 2/219 82/18639 0.024390243902439 2.07584363514868 0.250679149481849 0.513558155206071 GO:0019209 kinase activator activity 3/219 148/18639 0.0202702702702703 1.72519437245465 0.25238115136033 0.513558155206071 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/219 83/18639 0.0240963855421687 2.05083347086978 0.255034306115101 0.513558155206071 GO:0008139 nuclear localization sequence binding 1/219 25/18639 0.04 3.40438356164384 0.255966897689192 0.513558155206071 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/219 25/18639 0.04 3.40438356164384 0.255966897689192 0.513558155206071 GO:0042974 nuclear retinoic acid receptor binding 1/219 25/18639 0.04 3.40438356164384 0.255966897689192 0.513558155206071 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/219 25/18639 0.04 3.40438356164384 0.255966897689192 0.513558155206071 GO:0017018 myosin phosphatase activity 2/219 84/18639 0.0238095238095238 2.02641878669276 0.259391022667416 0.513558155206071 GO:0051117 ATPase binding 2/219 84/18639 0.0238095238095238 2.02641878669276 0.259391022667416 0.513558155206071 GO:0001637 G protein-coupled chemoattractant receptor activity 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0004529 DNA exonuclease activity 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0004950 chemokine receptor activity 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0008157 protein phosphatase 1 binding 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0015145 monosaccharide transmembrane transporter activity 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0030247 polysaccharide binding 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0030507 spectrin binding 1/219 26/18639 0.0384615384615385 3.27344573234984 0.26472069855983 0.513558155206071 GO:0008266 poly(U) RNA binding 1/219 27/18639 0.037037037037037 3.15220700152207 0.273371972777603 0.521878355427702 GO:0015252 proton channel activity 1/219 27/18639 0.037037037037037 3.15220700152207 0.273371972777603 0.521878355427702 GO:0035255 ionotropic glutamate receptor binding 1/219 27/18639 0.037037037037037 3.15220700152207 0.273371972777603 0.521878355427702 GO:0140375 immune receptor activity 3/219 156/18639 0.0192307692307692 1.63672286617492 0.277737908538795 0.521878355427702 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/219 89/18639 0.0224719101123595 1.91257503463137 0.281176288669393 0.521878355427702 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/219 89/18639 0.0224719101123595 1.91257503463137 0.281176288669393 0.521878355427702 GO:0016866 intramolecular transferase activity 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0046875 ephrin receptor binding 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0046966 nuclear thyroid hormone receptor binding 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0050698 proteoglycan sulfotransferase activity 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0051119 sugar transmembrane transporter activity 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0097718 disordered domain specific binding 1/219 28/18639 0.0357142857142857 3.03962818003914 0.281921915715584 0.521878355427702 GO:0140793 histone H2AXY142 phosphatase activity 2/219 90/18639 0.0222222222222222 1.89132420091324 0.2855295337994 0.524708820837514 GO:0005085 guanyl-nucleotide exchange factor activity 4/219 230/18639 0.0173913043478261 1.4801667659321 0.285614698352791 0.524708820837514 GO:0072341 modified amino acid binding 2/219 91/18639 0.021978021978022 1.87054041848562 0.28988019207717 0.525741382934703 GO:0003785 actin monomer binding 1/219 29/18639 0.0344827586206897 2.9348134152102 0.290371708873302 0.525741382934703 GO:0043236 laminin binding 1/219 29/18639 0.0344827586206897 2.9348134152102 0.290371708873302 0.525741382934703 GO:0099106 ion channel regulator activity 3/219 160/18639 0.01875 1.59580479452055 0.290512764178352 0.525741382934703 GO:0008187 poly-pyrimidine tract binding 1/219 30/18639 0.0333333333333333 2.83698630136986 0.298722520037017 0.534443057085823 GO:0016769 transferase activity, transferring nitrogenous groups 1/219 30/18639 0.0333333333333333 2.83698630136986 0.298722520037017 0.534443057085823 GO:0098918 structural constituent of synapse 1/219 30/18639 0.0333333333333333 2.83698630136986 0.298722520037017 0.534443057085823 GO:0015631 tubulin binding 6/219 385/18639 0.0155844155844156 1.32638320583526 0.299728889747101 0.534443057085823 GO:0008327 methyl-CpG binding 1/219 31/18639 0.032258064516129 2.7454706142289 0.306975503438161 0.543369048056599 GO:0047499 calcium-independent phospholipase A2 activity 1/219 31/18639 0.032258064516129 2.7454706142289 0.306975503438161 0.543369048056599 GO:0051020 GTPase binding 5/219 315/18639 0.0158730158730159 1.35094585779517 0.312129557428376 0.547809759700092 GO:0030515 snoRNA binding 1/219 32/18639 0.03125 2.65967465753425 0.31513179990995 0.547809759700092 GO:0031369 translation initiation factor binding 1/219 32/18639 0.03125 2.65967465753425 0.31513179990995 0.547809759700092 GO:0047498 calcium-dependent phospholipase A2 activity 1/219 32/18639 0.03125 2.65967465753425 0.31513179990995 0.547809759700092 GO:0140142 nucleocytoplasmic carrier activity 1/219 32/18639 0.03125 2.65967465753425 0.31513179990995 0.547809759700092 GO:0004725 protein tyrosine phosphatase activity 2/219 98/18639 0.0204081632653061 1.73693038859379 0.320218768344028 0.552690756750369 GO:0042626 ATPase-coupled transmembrane transporter activity 2/219 98/18639 0.0204081632653061 1.73693038859379 0.320218768344028 0.552690756750369 GO:0035402 histone H3T11 kinase activity 4/219 247/18639 0.0161943319838057 1.37829293993678 0.330554567986035 0.565535324743517 GO:0015035 protein-disulfide reductase activity 1/219 34/18639 0.0294117647058824 2.50322320709106 0.331158829334348 0.565535324743517 GO:0090482 vitamin transmembrane transporter activity 1/219 34/18639 0.0294117647058824 2.50322320709106 0.331158829334348 0.565535324743517 GO:0000175 3'-5'-RNA exonuclease activity 1/219 35/18639 0.0285714285714286 2.43170254403131 0.339031778346752 0.568963365045587 GO:0004623 phospholipase A2 activity 1/219 35/18639 0.0285714285714286 2.43170254403131 0.339031778346752 0.568963365045587 GO:0005154 epidermal growth factor receptor binding 1/219 35/18639 0.0285714285714286 2.43170254403131 0.339031778346752 0.568963365045587 GO:0061631 ubiquitin conjugating enzyme activity 1/219 35/18639 0.0285714285714286 2.43170254403131 0.339031778346752 0.568963365045587 GO:0140566 histone reader activity 1/219 35/18639 0.0285714285714286 2.43170254403131 0.339031778346752 0.568963365045587 GO:0004722 protein serine/threonine phosphatase activity 2/219 103/18639 0.0194174757281553 1.65261337943875 0.341702926720336 0.571468687790907 GO:0005484 SNAP receptor activity 1/219 36/18639 0.0277777777777778 2.36415525114155 0.346812472850196 0.57407525369401 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/219 36/18639 0.0277777777777778 2.36415525114155 0.346812472850196 0.57407525369401 GO:0045505 dynein intermediate chain binding 1/219 36/18639 0.0277777777777778 2.36415525114155 0.346812472850196 0.57407525369401 GO:0003713 transcription coactivator activity 4/219 256/18639 0.015625 1.32983732876712 0.354533385699222 0.584859496816743 GO:0019888 protein phosphatase regulator activity 2/219 107/18639 0.0186915887850467 1.59083344002048 0.358737427538864 0.588766708124865 GO:0000146 microfilament motor activity 1/219 38/18639 0.0263157894736842 2.23972602739726 0.362101390350703 0.588766708124865 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/219 38/18639 0.0263157894736842 2.23972602739726 0.362101390350703 0.588766708124865 GO:0042162 telomeric DNA binding 1/219 38/18639 0.0263157894736842 2.23972602739726 0.362101390350703 0.588766708124865 GO:0004843 cysteine-type deubiquitinase activity 2/219 108/18639 0.0185185185185185 1.57610350076103 0.36297164067904 0.588766708124865 GO:0003730 mRNA 3'-UTR binding 4/219 262/18639 0.0152671755725191 1.29938303879536 0.370527932581413 0.599020157673285 GO:0004532 RNA exonuclease activity 1/219 40/18639 0.025 2.1277397260274 0.377034041785413 0.601518125874755 GO:0015144 carbohydrate transmembrane transporter activity 1/219 40/18639 0.025 2.1277397260274 0.377034041785413 0.601518125874755 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/219 40/18639 0.025 2.1277397260274 0.377034041785413 0.601518125874755 GO:0140662 ATP-dependent protein folding chaperone 1/219 40/18639 0.025 2.1277397260274 0.377034041785413 0.601518125874755 GO:0042287 MHC protein binding 1/219 41/18639 0.024390243902439 2.07584363514868 0.384369357923323 0.611210290468235 GO:0004520 DNA endonuclease activity 1/219 42/18639 0.0238095238095238 2.02641878669276 0.391618691755714 0.613758994525941 GO:0008307 structural constituent of muscle 1/219 42/18639 0.0238095238095238 2.02641878669276 0.391618691755714 0.613758994525941 GO:0035401 histone H3Y41 kinase activity 2/219 115/18639 0.0173913043478261 1.4801667659321 0.392299563511426 0.613758994525941 GO:0101005 deubiquitinase activity 2/219 115/18639 0.0173913043478261 1.4801667659321 0.392299563511426 0.613758994525941 GO:0140801 histone H2AXY142 kinase activity 2/219 115/18639 0.0173913043478261 1.4801667659321 0.392299563511426 0.613758994525941 GO:0019208 phosphatase regulator activity 2/219 117/18639 0.0170940170940171 1.45486476993326 0.400569563281122 0.622680250613282 GO:1990782 protein tyrosine kinase binding 2/219 117/18639 0.0170940170940171 1.45486476993326 0.400569563281122 0.622680250613282 GO:0005126 cytokine receptor binding 4/219 275/18639 0.0145454545454545 1.23795765877958 0.405066791719554 0.626890942014411 GO:0043014 alpha-tubulin binding 1/219 44/18639 0.0227272727272727 1.93430884184309 0.405863414005206 0.626890942014411 GO:0008017 microtubule binding 4/219 276/18639 0.0144927536231884 1.23347230494342 0.407711730825199 0.627746633175306 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/219 45/18639 0.0222222222222222 1.89132420091324 0.412860774173685 0.631663960486553 GO:0008009 chemokine activity 1/219 45/18639 0.0222222222222222 1.89132420091324 0.412860774173685 0.631663960486553 GO:0016829 lyase activity 3/219 200/18639 0.015 1.27664383561644 0.418177792499761 0.634241141640356 GO:0030246 carbohydrate binding 4/219 280/18639 0.0142857142857143 1.21585127201566 0.418268018445468 0.634241141640356 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/219 46/18639 0.0217391304347826 1.85020845741513 0.419776095807328 0.634241141640356 GO:0030291 protein serine/threonine kinase inhibitor activity 1/219 46/18639 0.0217391304347826 1.85020845741513 0.419776095807328 0.634241141640356 GO:0001784 phosphotyrosine residue binding 1/219 47/18639 0.0212765957446809 1.81084232002332 0.426610336382717 0.638598806004992 GO:0005504 fatty acid binding 1/219 47/18639 0.0212765957446809 1.81084232002332 0.426610336382717 0.638598806004992 GO:0140359 ABC-type transporter activity 1/219 47/18639 0.0212765957446809 1.81084232002332 0.426610336382717 0.638598806004992 GO:0140693 molecular condensate scaffold activity 1/219 48/18639 0.0208333333333333 1.77311643835616 0.433364442252563 0.646713090746132 GO:0005516 calmodulin binding 3/219 207/18639 0.0144927536231884 1.23347230494342 0.439946223392535 0.652219717314231 GO:0001222 transcription corepressor binding 1/219 49/18639 0.0204081632653061 1.73693038859379 0.440039348774358 0.652219717314231 GO:0019783 ubiquitin-like protein peptidase activity 2/219 127/18639 0.015748031496063 1.34030848883616 0.441088798513542 0.652219717314231 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 2/219 128/18639 0.015625 1.32983732876712 0.445059131538072 0.654436406381279 GO:0051015 actin filament binding 3/219 209/18639 0.0143540669856459 1.22166874221669 0.446110063177588 0.654436406381279 GO:0048020 CCR chemokine receptor binding 1/219 50/18639 0.02 1.70219178082192 0.446635980437533 0.654436406381279 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/219 130/18639 0.0153846153846154 1.30937829293994 0.452952674476454 0.660000891080306 GO:0016830 carbon-carbon lyase activity 1/219 51/18639 0.0196078431372549 1.66881547139404 0.453155250989159 0.660000891080306 GO:0005246 calcium channel regulator activity 1/219 53/18639 0.0188679245283019 1.60584130266219 0.465965310778342 0.668618863099101 GO:0008146 sulfotransferase activity 1/219 53/18639 0.0188679245283019 1.60584130266219 0.465965310778342 0.668618863099101 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/219 53/18639 0.0188679245283019 1.60584130266219 0.465965310778342 0.668618863099101 GO:0016860 intramolecular oxidoreductase activity 1/219 53/18639 0.0188679245283019 1.60584130266219 0.465965310778342 0.668618863099101 GO:0051018 protein kinase A binding 1/219 53/18639 0.0188679245283019 1.60584130266219 0.465965310778342 0.668618863099101 GO:0017069 snRNA binding 1/219 54/18639 0.0185185185185185 1.57610350076103 0.472257874909384 0.669722424944595 GO:0050661 NADP binding 1/219 54/18639 0.0185185185185185 1.57610350076103 0.472257874909384 0.669722424944595 GO:0051287 NAD binding 1/219 54/18639 0.0185185185185185 1.57610350076103 0.472257874909384 0.669722424944595 GO:0140463 chromatin-protein adaptor activity 1/219 54/18639 0.0185185185185185 1.57610350076103 0.472257874909384 0.669722424944595 GO:0140789 histone phosphatase activity 2/219 136/18639 0.0147058823529412 1.25161160354553 0.476244053631533 0.673406314901731 GO:0008374 O-acyltransferase activity 1/219 55/18639 0.0181818181818182 1.54744707347447 0.478476627957264 0.674596408602538 GO:0030295 protein kinase activator activity 2/219 139/18639 0.0143884892086331 1.22459840346901 0.487663250822729 0.685555584489923 GO:0016504 peptidase activator activity 1/219 57/18639 0.0175438596491228 1.49315068493151 0.490696138268351 0.68687628011247 GO:0004713 protein tyrosine kinase activity 2/219 140/18639 0.0142857142857143 1.21585127201566 0.491435194224798 0.68687628011247 GO:0008408 3'-5' exonuclease activity 1/219 58/18639 0.0172413793103448 1.4674067076051 0.496698589334933 0.69223797651564 GO:0020037 heme binding 2/219 142/18639 0.0140845070422535 1.19872660621262 0.498926683576802 0.692545026478585 GO:0036002 pre-mRNA binding 1/219 59/18639 0.0169491525423729 1.4425354074762 0.502630617155591 0.692545026478585 GO:0045309 protein phosphorylated amino acid binding 1/219 59/18639 0.0169491525423729 1.4425354074762 0.502630617155591 0.692545026478585 GO:0070063 RNA polymerase binding 1/219 59/18639 0.0169491525423729 1.4425354074762 0.502630617155591 0.692545026478585 GO:0019903 protein phosphatase binding 2/219 144/18639 0.0138888888888889 1.18207762557078 0.506347584357277 0.692750355186349 GO:0001098 basal transcription machinery binding 1/219 60/18639 0.0166666666666667 1.41849315068493 0.508493044219258 0.692750355186349 GO:0001099 basal RNA polymerase II transcription machinery binding 1/219 60/18639 0.0166666666666667 1.41849315068493 0.508493044219258 0.692750355186349 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/219 60/18639 0.0166666666666667 1.41849315068493 0.508493044219258 0.692750355186349 GO:0015026 coreceptor activity 1/219 61/18639 0.0163934426229508 1.39523916460813 0.514286683452585 0.69478841636352 GO:0016836 hydro-lyase activity 1/219 61/18639 0.0163934426229508 1.39523916460813 0.514286683452585 0.69478841636352 GO:0019905 syntaxin binding 1/219 61/18639 0.0163934426229508 1.39523916460813 0.514286683452585 0.69478841636352 GO:0005125 cytokine activity 3/219 234/18639 0.0128205128205128 1.09114857744995 0.520602170195025 0.701366812623853 GO:0046906 tetrapyrrole binding 2/219 152/18639 0.0131578947368421 1.11986301369863 0.535310379157174 0.702040670256231 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/219 243/18639 0.0123456790123457 1.05073566717402 0.546078448247691 0.702040670256231 GO:0050840 extracellular matrix binding 1/219 67/18639 0.0149253731343284 1.2702923737477 0.547648321081606 0.702040670256231 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0004711 ribosomal protein S6 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0035175 histone H3S10 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0035979 histone H2AXS139 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0044022 histone H3S28 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0044023 histone H4S1 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0044024 histone H2AS1 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0044025 histone H2BS14 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0072354 histone H3T3 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0072371 histone H2AS121 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140823 histone H2BS36 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140855 histone H3S57 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140995 histone H2A kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140997 histone H4 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140998 histone H2B kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:1990244 histone H2AT120 kinase activity 3/219 245/18639 0.0122448979591837 1.04215823315628 0.551632803951305 0.702040670256231 GO:0140223 general transcription initiation factor activity 1/219 68/18639 0.0147058823529412 1.25161160354553 0.552982427138204 0.702040670256231 GO:0004677 DNA-dependent protein kinase activity 3/219 246/18639 0.0121951219512195 1.03792181757434 0.554395003521931 0.702040670256231 GO:0140857 histone H3T45 kinase activity 3/219 246/18639 0.0121951219512195 1.03792181757434 0.554395003521931 0.702040670256231 GO:0035403 histone H3T6 kinase activity 3/219 247/18639 0.0121457489878543 1.03371970495258 0.557147140024421 0.702518789583062 GO:0008080 N-acetyltransferase activity 1/219 69/18639 0.0144927536231884 1.23347230494342 0.558253917551037 0.702518789583062 GO:0004679 AMP-activated protein kinase activity 3/219 248/18639 0.0120967741935484 1.02955148033584 0.559889157354074 0.702518789583062 GO:0140104 molecular carrier activity 3/219 249/18639 0.0120481927710843 1.02541673543489 0.562621001029749 0.702518789583062 GO:0016782 transferase activity, transferring sulphur-containing groups 1/219 70/18639 0.0142857142857143 1.21585127201566 0.563463524016106 0.702518789583062 GO:0097110 scaffold protein binding 1/219 70/18639 0.0142857142857143 1.21585127201566 0.563463524016106 0.702518789583062 GO:0008083 growth factor activity 2/219 162/18639 0.0123456790123457 1.05073566717402 0.569850445258005 0.708660169102904 GO:0042379 chemokine receptor binding 1/219 72/18639 0.0138888888888889 1.18207762557078 0.573699969428994 0.71162272422778 GO:0004674 protein serine/threonine kinase activity 5/219 433/18639 0.0115473441108545 0.982789711790946 0.57803592267003 0.714206593787816 GO:0043539 protein serine/threonine kinase activator activity 1/219 73/18639 0.0136986301369863 1.16588478138488 0.578728229605385 0.714206593787816 GO:0003684 damaged DNA binding 1/219 74/18639 0.0135135135135135 1.15012958163643 0.583697448484864 0.718510818566394 GO:0044183 protein folding chaperone 1/219 75/18639 0.0133333333333333 1.13479452054795 0.588608316181165 0.722721603412317 GO:0051536 iron-sulfur cluster binding 1/219 76/18639 0.0131578947368421 1.11986301369863 0.593461514778252 0.726840491584475 GO:0003724 RNA helicase activity 1/219 77/18639 0.012987012987013 1.10531933819605 0.598257718423329 0.729032646822398 GO:0051540 metal cluster binding 1/219 77/18639 0.012987012987013 1.10531933819605 0.598257718423329 0.729032646822398 GO:0141003 histone H2AX kinase activity 4/219 354/18639 0.0112994350282486 0.961690271650801 0.600382997755938 0.729788856921379 GO:0140030 modification-dependent protein binding 2/219 173/18639 0.0115606936416185 0.98392588486816 0.605665136709776 0.731329211369204 GO:0140996 histone H3 kinase activity 4/219 357/18639 0.0112044817927171 0.953608840796593 0.607039075000219 0.731329211369204 GO:0008186 ATP-dependent activity, acting on RNA 1/219 79/18639 0.0126582278481013 1.07733657014045 0.607681798312968 0.731329211369204 GO:0033293 monocarboxylic acid binding 1/219 79/18639 0.0126582278481013 1.07733657014045 0.607681798312968 0.731329211369204 GO:0004721 phosphoprotein phosphatase activity 2/219 175/18639 0.0114285714285714 0.972681017612524 0.611930148156856 0.733028265887148 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/219 268/18639 0.0111940298507463 0.952719280310775 0.6125318678666 0.733028265887148 GO:0035173 histone kinase activity 4/219 360/18639 0.0111111111111111 0.945662100456621 0.613627785464293 0.733028265887148 GO:0030971 receptor tyrosine kinase binding 1/219 81/18639 0.0123456790123457 1.05073566717402 0.616885793759378 0.735109606814001 GO:0005096 GTPase activator activity 3/219 271/18639 0.011070110701107 0.942172572410656 0.6200567534919 0.737077268244048 GO:0001540 amyloid-beta binding 1/219 83/18639 0.0120481927710843 1.02541673543489 0.625874821457996 0.740198536252733 GO:0005254 chloride channel activity 1/219 83/18639 0.0120481927710843 1.02541673543489 0.625874821457996 0.740198536252733 GO:0016853 isomerase activity 2/219 180/18639 0.0111111111111111 0.945662100456621 0.627261027628605 0.740198536252733 GO:0004527 exonuclease activity 1/219 84/18639 0.0119047619047619 1.01320939334638 0.630290288913304 0.741967937191632 GO:0001217 DNA-binding transcription repressor activity 3/219 278/18639 0.0107913669064748 0.918448802601754 0.637228313763282 0.747000269370988 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/219 86/18639 0.0116279069767442 0.989646384198789 0.638966200494995 0.747000269370988 GO:0008237 metallopeptidase activity 2/219 184/18639 0.0108695652173913 0.925104228707564 0.63918579750301 0.747000269370988 GO:0008234 cysteine-type peptidase activity 2/219 187/18639 0.0106951871657754 0.910262984396747 0.64793214874913 0.755018154556814 GO:0031267 small GTPase binding 3/219 283/18639 0.0106007067137809 0.90222179195508 0.649159939072559 0.755018154556814 GO:0019902 phosphatase binding 2/219 190/18639 0.0105263157894737 0.895890410958904 0.656510430359167 0.761740571110517 GO:0051219 phosphoprotein binding 1/219 93/18639 0.010752688172043 0.915156871409633 0.667766389620154 0.772951548844331 GO:0016410 N-acyltransferase activity 1/219 94/18639 0.0106382978723404 0.905421160011658 0.671689562308237 0.77564151837975 GO:0004896 cytokine receptor activity 1/219 96/18639 0.0104166666666667 0.886558219178082 0.679398094426365 0.780824824163002 GO:0016407 acetyltransferase activity 1/219 96/18639 0.0104166666666667 0.886558219178082 0.679398094426365 0.780824824163002 GO:0005543 phospholipid binding 5/219 497/18639 0.0100603621730382 0.85623329015187 0.697922625541623 0.800218613209662 GO:0005253 monoatomic anion channel activity 1/219 103/18639 0.00970873786407767 0.826306689719377 0.704986280407661 0.806411193390838 GO:0004518 nuclease activity 2/219 209/18639 0.00956937799043062 0.814445828144458 0.707014121825191 0.806827880200512 GO:0000149 SNARE binding 1/219 106/18639 0.00943396226415094 0.802920651331093 0.7153204001384 0.812483358471016 GO:0008013 beta-catenin binding 1/219 106/18639 0.00943396226415094 0.802920651331093 0.7153204001384 0.812483358471016 GO:0004620 phospholipase activity 1/219 109/18639 0.00917431192660551 0.780821917808219 0.725294118198131 0.820045857090683 GO:0016887 ATP hydrolysis activity 4/219 417/18639 0.00959232613908873 0.816398935646004 0.725360149880212 0.820045857090683 GO:0004222 metalloendopeptidase activity 1/219 110/18639 0.00909090909090909 0.773723536737235 0.728540777027846 0.821726225252338 GO:1902936 phosphatidylinositol bisphosphate binding 1/219 111/18639 0.00900900900900901 0.766753054424287 0.731749237809912 0.823430116793056 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/219 229/18639 0.00873362445414847 0.743315188131842 0.753357096411287 0.845782851295079 GO:0140097 catalytic activity, acting on DNA 3/219 336/18639 0.00892857142857143 0.759907045009785 0.758537604617298 0.849395374599607 GO:0004540 RNA nuclease activity 1/219 121/18639 0.00826446280991736 0.703385033397487 0.76182884113573 0.849395374599607 GO:0015108 chloride transmembrane transporter activity 1/219 121/18639 0.00826446280991736 0.703385033397487 0.76182884113573 0.849395374599607 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/219 122/18639 0.00819672131147541 0.697619582304065 0.764645532127807 0.850580465784372 GO:0004519 endonuclease activity 1/219 127/18639 0.0078740157480315 0.670154244418078 0.778239279935948 0.860723708296845 GO:0042826 histone deacetylase binding 1/219 127/18639 0.0078740157480315 0.670154244418078 0.778239279935948 0.860723708296845 GO:0005539 glycosaminoglycan binding 2/219 242/18639 0.00826446280991736 0.703385033397487 0.779991849501383 0.860723708296845 GO:0031490 chromatin DNA binding 1/219 128/18639 0.0078125 0.664918664383562 0.780862745671364 0.860723708296845 GO:0016298 lipase activity 1/219 130/18639 0.00769230769230769 0.654689146469968 0.786017351400715 0.864440851313711 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/219 132/18639 0.00757575757575758 0.644769613947696 0.791051249760733 0.868008724284968 GO:0106310 protein serine kinase activity 3/219 361/18639 0.00831024930747922 0.707281903388609 0.799734986704419 0.872747271420764 GO:0016779 nucleotidyltransferase activity 1/219 136/18639 0.00735294117647059 0.625805801772764 0.800768115014928 0.872747271420764 GO:0019838 growth factor binding 1/219 136/18639 0.00735294117647059 0.625805801772764 0.800768115014928 0.872747271420764 GO:0070851 growth factor receptor binding 1/219 139/18639 0.00719424460431655 0.612299201734503 0.807759365218503 0.878393031683798 GO:0016757 glycosyltransferase activity 2/219 267/18639 0.00749063670411985 0.637525011543789 0.824219602044114 0.886649721787441 GO:0008509 monoatomic anion transmembrane transporter activity 1/219 149/18639 0.00671140939597315 0.571205295577825 0.829346682741348 0.886649721787441 GO:0000510 H3-H4 histone complex chaperone activity 1/219 151/18639 0.00662251655629139 0.563639662523814 0.83336536823046 0.886649721787441 GO:0140584 chromatin extrusion motor activity 1/219 151/18639 0.00662251655629139 0.563639662523814 0.83336536823046 0.886649721787441 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/219 151/18639 0.00662251655629139 0.563639662523814 0.83336536823046 0.886649721787441 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/219 151/18639 0.00662251655629139 0.563639662523814 0.83336536823046 0.886649721787441 GO:0016791 phosphatase activity 2/219 273/18639 0.00732600732600733 0.623513472828541 0.833577413478549 0.886649721787441 GO:0015616 DNA translocase activity 1/219 152/18639 0.00657894736842105 0.559931506849315 0.835339242330283 0.886649721787441 GO:0140674 ATP-dependent histone chaperone activity 1/219 152/18639 0.00657894736842105 0.559931506849315 0.835339242330283 0.886649721787441 GO:0140098 catalytic activity, acting on RNA 3/219 387/18639 0.00775193798449612 0.659764256132526 0.836199109366615 0.886649721787441 GO:1901681 sulfur compound binding 2/219 275/18639 0.00727272727272727 0.618978829389788 0.836595800694253 0.886649721787441 GO:0061775 cohesin loader activity 1/219 153/18639 0.0065359477124183 0.556271823798012 0.837289840368346 0.886649721787441 GO:0004386 helicase activity 1/219 155/18639 0.00645161290322581 0.54909412284578 0.841122297981198 0.888767569762268 GO:0140658 ATP-dependent chromatin remodeler activity 1/219 158/18639 0.00632911392405063 0.538668285070227 0.846703141667831 0.892719616758474 GO:0003689 DNA clamp loader activity 1/219 160/18639 0.00625 0.531934931506849 0.85031485047552 0.894508818515677 GO:0005178 integrin binding 1/219 161/18639 0.0062111801242236 0.528630987832894 0.852088812689161 0.894508818515677 GO:0140713 histone chaperone activity 1/219 164/18639 0.00609756097560976 0.51896090878717 0.857286106385722 0.895923098836406 GO:0004175 endopeptidase activity 3/219 405/18639 0.00740740740740741 0.630441400304414 0.85797955103618 0.895923098836406 GO:0015103 inorganic anion transmembrane transporter activity 1/219 165/18639 0.00606060606060606 0.515815691158157 0.858977816410162 0.895923098836406 GO:0016874 ligase activity 1/219 167/18639 0.00598802395209581 0.509638257731113 0.862301582556602 0.89745980158788 GO:0001664 G protein-coupled receptor binding 2/219 297/18639 0.00673400673400673 0.573128545731285 0.866680746655285 0.90008600027369 GO:0008201 heparin binding 1/219 172/18639 0.00581395348837209 0.494823192099395 0.870273770011925 0.901886278751675 GO:1901981 phosphatidylinositol phosphate binding 1/219 185/18639 0.00540540540540541 0.460051832654572 0.888915932794838 0.918721846596214 GO:0031406 carboxylic acid binding 1/219 187/18639 0.0053475935828877 0.455131492198374 0.891536905068539 0.918721846596214 GO:0140597 protein carrier chaperone 1/219 188/18639 0.00531914893617021 0.452710580005829 0.892824213641593 0.918721846596214 GO:0043177 organic acid binding 1/219 189/18639 0.00529100529100529 0.450315285931724 0.894096312563738 0.918721846596214 GO:0016758 hexosyltransferase activity 1/219 197/18639 0.0050761421319797 0.432028370766984 0.903746589401496 0.926674621267919 GO:0008094 ATP-dependent activity, acting on DNA 1/219 210/18639 0.00476190476190476 0.405283757338552 0.917596019702565 0.938890442100726 GO:0019787 ubiquitin-like protein transferase activity 3/219 479/18639 0.00626304801670146 0.533045442846112 0.923079071159166 0.941528192800176 GO:0045182 translation regulator activity 2/219 356/18639 0.00561797752808989 0.478143758657842 0.924056535614193 0.941528192800176 GO:0042578 phosphoric ester hydrolase activity 2/219 363/18639 0.00550964187327824 0.468923355598324 0.92906426759389 0.94464605824536 GO:0016755 aminoacyltransferase activity 3/219 496/18639 0.00604838709677419 0.514775740167919 0.933545169245549 0.947216332811906 GO:0033218 amide binding 1/219 247/18639 0.00404858299595142 0.344573234984194 0.947074899700126 0.956940263238669 GO:0042393 histone binding 1/219 247/18639 0.00404858299595142 0.344573234984194 0.947074899700126 0.956940263238669 GO:0008514 organic anion transmembrane transporter activity 1/219 269/18639 0.00371747211895911 0.316392524316342 0.959342131385292 0.967320028527789 GO:0035091 phosphatidylinositol binding 1/219 284/18639 0.00352112676056338 0.299681651553155 0.966038595021377 0.971945632467992 GO:0005216 monoatomic ion channel activity 2/219 448/18639 0.00446428571428571 0.379953522504892 0.969634058845735 0.971945632467992 GO:0004842 ubiquitin-protein transferase activity 2/219 449/18639 0.0044543429844098 0.379107300851207 0.969941620854656 0.971945632467992 GO:0005261 monoatomic cation channel activity 1/219 341/18639 0.00293255131964809 0.249588237657173 0.982884308645095 0.982884308645095