category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	73/301	222/9376	10.2428541498309	RPL23A/RPS3A/RPLP0/RPS10/RPS20/RPL13A/RPS13/RPL6/RPS6/RPS11/RPL27A/RPL31/RPS16/RPL7/RPL9/RPL14/RPL26/RPS8/RPL21/RPS25/RPL23/RPL24/RPL13/RPL15/RPL17/RPL18A/RPL19/RPS2/UBA52/RPS4X/RPL10A/RPL28/RPL7A/RPLP2/RPS12/RPLP1/RPS3/RPL10/RPL8/RPS27A/RPS17/RPL3/RPSA/RPL4/RPL27/RPL22/RPL29/RPL36A/RPS26/RPL12/RPS19/RPL32/RPS15A/RPS24/RPL5/RPS5/RPL11/RPL35A/RPS23/RPL35/RPS14/RPL38/RPL30/MRPS6/RPS9/RPL34/RPL37/RPL41/RPS18/MRPS15/MRPL51/RPL36AL/MRPL52	25.3818166360083
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	71/301	238/9376	9.29249839470672	RPL23A/RPS3A/RPLP0/RPS10/RPS20/RPL13A/RPS13/RPL6/RPS6/RPS11/RPL27A/RPL31/RPS16/RPL7/RPL9/RPL14/RPL26/RPS8/RPL21/RPS25/RPL23/RPL24/RPL13/RPL15/RPL17/RPL18A/RPL19/RPS2/UBA52/RPS4X/RPL10A/RPL28/RPL7A/RPLP2/RPS12/RPLP1/RPS3/RPL10/RPL8/RPS27A/RPS17/RPL3/RPSA/RPL4/RPL27/RPL22/RPL29/RPL36A/RPS26/RPL12/RPS19/RPL32/RPS15A/RPS24/RPL5/RPS5/RPL11/RPL35A/RPS23/RPL35/RPS14/RPL38/RPL30/RPS9/RPL34/RPL37/RPL41/MX1/RPS18/ISG15/RPL36AL	23.5990144898894
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/301	268/9376	6.1601626419398	UBA52/RPS27A/UQCRH/VDAC1/TXN/CALM1/TUBA1C/UBE2L3/TUBA1B/PSMA2/COX7B2/TUBB4B/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/PARK7/PSMA1/VDAC2/SLC25A5/CALM2/SLC25A6/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/PSMB7/UQCRQ/SOD1/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/UBE2J1/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/TUBB/MT-ND5/NDUFA6	15.608632141835
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/301	275/9376	5.55027484143763	CAV1/UQCRH/VDAC1/TUBA1C/TUBA1B/PSMA2/COX7B2/TUBB4B/CSNK2B/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/PSMA1/VDAC2/SLC25A5/SLC25A6/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/RAC1/PSMB7/UQCRQ/SOD1/CCL5/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/TUBB/MT-ND5/NDUFA6	13.947776775324
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/301	308/9376	4.95560253699789	GPX3/GPX1/UQCRH/VDAC1/TUBA1C/TUBA1B/PSMA2/COX7B2/TUBB4B/CLTA/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/PSMA1/VDAC2/SLC25A5/SLC25A6/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/PSMB7/UQCRQ/SOD1/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/CLTB/TUBB/MT-ND5/NDUFA6	12.8551698280717
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/301	368/9376	4.23226924743608	PFN1/GPX3/ACTG1/HNRNPA1/GPX1/UQCRH/VDAC1/TUBA1C/TUBA1B/PSMA2/COX7B2/TUBB4B/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/SRSF3/PSMA1/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/RAC1/HNRNPA3/PSMB7/UQCRQ/SOD1/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/TUBB/MT-ND5/NDUFA6	11.5202743036753
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/301	480/9376	3.63410852713178	UBA52/GPX3/RPS27A/GPX1/UQCRH/VDAC1/CALM1/TUBA1C/UBE2L3/TUBA1B/PSMA2/COX7B2/TUBB4B/CSNK2B/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/PARK7/PSMA1/VDAC2/SLC25A5/CALM2/SLC25A6/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/RAC1/PSMB7/UQCRQ/SOD1/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/UBE2J1/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/TUBB/MT-ND5/NDUFA6	10.7895284607509
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	48/301	388/9376	3.85354659725314	GAPDH/UQCRH/VDAC1/CALM1/TUBA1C/TUBA1B/PSMA2/COX7B2/TUBB4B/CSNK2B/COX8C/COX7B/PSMD8/MT-ATP6/COX5A/PSMB3/PSMA1/VDAC2/SLC25A5/CALM2/SLC25A6/PSMA5/PSMB2/COX7C/NDUFB3/PSMA7/UQCRB/NDUFA11/PSMB7/UQCRQ/CYCS/NDUFB6/COX8A/PSMD4/UQCRFS1/TUBB6/PSMC1/SDHB/PSMB4/PSMD14/PSMA4/NDUFA12/NDUFB4/UQCR11/NDUFS5/TUBB/MT-ND5/NDUFA6	10.4547792891887
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/301	46/9376	10.8346092734364	POMP/PSMA2/PSMD8/PSMB3/PSME2/PSMA1/PSME1/PSMA5/PSMB2/PSMA7/PSMB7/PSMD4/PSMC1/PSMB4/PSMD14/PSMA4	12.1770131013248
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	29/301	205/9376	4.4065148691354	GAPDH/UQCRH/VDAC1/COX7B2/COX8C/COX7B/MT-ATP6/COX5A/VDAC2/SLC25A5/SLC25A6/COX7C/NDUFB3/PPP1CA/UQCRB/NDUFA11/RAC1/UQCRQ/NDUFB6/COX8A/UQCRFS1/SDHB/NDUFA12/NDUFB4/UQCR11/NDUFS5/TGFB1/MT-ND5/NDUFA6	8.98099473696127
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/301	138/9376	5.19158361018826	UQCRH/COX7B2/COX8C/PPA1/COX7B/MT-ATP6/COX5A/COX7C/NDUFB3/UQCRB/NDUFA11/UQCRQ/CYCS/NDUFB6/COX8A/UQCRFS1/SDHB/NDUFA12/NDUFB4/UQCR11/NDUFS5/MT-ND5/NDUFA6	9.03387895002338
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/301	227/9376	3.84222927978691	GSTO1/UQCRH/VDAC1/COX7B2/COX8C/COX7B/MT-ATP6/COX5A/VDAC2/SLC25A5/SLC25A6/COX7C/NDUFB3/UQCRB/NDUFA11/RAC1/UQCRQ/SOD1/NDUFB6/COX8A/UQCRFS1/SDHB/NDUFA12/NDUFB4/UQCR11/NDUFS5/MT-ND5/NDUFA6	7.89461204802383
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/301	157/9376	4.56330279112089	UQCRH/CDC42/COX7B2/COX8C/COX7B/COX5A/COX7C/NDUFB3/UQCRB/NDUFA11/RAC1/UQCRQ/CYCS/NDUFB6/COX8A/UQCRFS1/SDHB/NDUFA12/NDUFB4/UQCR11/NDUFS5/TGFB1/NDUFA6	8.19985581506159
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/301	248/9376	3.14007073196871	GAPDH/DYNLL1/PFN1/RPS3/ACTG1/S100A10/TXN/MYL12B/SKP1/MYL12A/ARPC3/DYNLRB1/TUBA1C/CDC42/RHOA/ARPC2/TUBA1B/TUBB4B/DYNLT1/ARPC5/RAC1/CYCS/ANXA2/TUBB6/TUBB	6.22030559360034
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	24/301	235/9376	3.18122570156217	RPS6/ACTG1/UQCRH/COX20/COX7B2/COX8C/COX7B/MT-ATP6/COX5A/COX7C/NDUFB3/UQCRB/NDUFA11/UQCRQ/NDUFB6/COX8A/UQCRFS1/SDHB/NDUFA12/NDUFB4/UQCR11/NDUFS5/MT-ND5/NDUFA6	6.16713211511118
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/301	144/9376	3.8936877076412	VDAC1/PSMA2/PSMD8/PSMB3/PSMA1/VDAC2/SLC25A5/SLC25A6/PSMA5/PSMB2/PSMA7/PSMB7/CYCS/PSMD4/PSMC1/PSMB4/PSMD14/PSMA4	6.37280422070469
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/301	87/9376	4.65452323672051	UQCRH/TPM4/COX7B2/COX8C/COX7B/COX5A/COX7C/UQCRB/UQCRQ/TPM3/COX8A/UQCRFS1/UQCR11	6.23665099735227
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	13/301	116/9376	3.49089242754038	GAPDH/ALDOA/TPI1/ENO1/PKM/TALDO1/GCSH/SDHB/MDH1/ECHS1/PGK1/PGAM1/MDH2	4.91613774410165
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/301	78/9376	3.99352585399097	CAV1/ACTG1/ARPC3/CDC42/RHOA/ARPC2/CLTA/ARPC5/RAC1/CLTB	4.8348289387792
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/301	59/9376	4.22366124218706	GPX3/GSTO1/GPX1/PRDX6/GSTP1/GPX4/SMS/RRM2	4.5235867675858
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/301	200/9376	2.49196013289037	GAPDH/RPS3/ACTG1/ARPC3/TUBA1C/CDC42/RHOA/ARPC2/TUBA1B/TUBB4B/ARPC5/NCL/RAC1/CYCS/TUBB6/TUBB	3.88410608323465
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/301	243/9376	2.307370493417	HNRNPA1/SNRPD2/HNRNPC/SNRPE/LSM3/SNRPC/SRSF3/SF3B6/SNRPG/SNU13/HNRNPA3/SNRPF/SNRPD1/SF3B5/SNRPB/TXNL4A/SRSF9/SNRPD3	3.76045725203249
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/301	67/9376	3.71934348192592	GAPDH/LDHA/ALDOA/TPI1/ENO1/PKM/PGK1/PGAM1	4.06813655452943
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/301	194/9376	2.40846662328321	DYNLL1/ACTG1/MYL12B/MYL12A/DYNLRB1/TUBA1C/TPM4/MYL6/TUBA1B/TUBB4B/DYNLT1/CAPZB/TPM3/TUBB6/TUBB	3.61014254158288
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/301	138/9376	2.70865231835909	CALM1/SKP1/ANAPC11/CCNE1/YWHAE/CALM2/PPP1CA/CDK1/YWHAQ/PTTG1/CDC20/CCNB1	3.68256001722451
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/301	75/9376	3.32261351052049	GAPDH/ALDOA/TPI1/ENO1/PKM/TALDO1/PGK1/PGAM1	3.67780184751867
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/301	170/9376	2.38202071526285	ACTG1/MYL12B/MYL12A/ARPC3/TUBA1C/CDC42/RHOA/ARPC2/MYL6/TUBA1B/YBX3/ARPC5/RAC1	3.31168558229035
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/301	142/9376	2.41298956529877	UBA52/RPS27A/SKP1/ANAPC11/UBE2L3/UBE2C/UBE2I/UBE2E1/CDC20/UBE2J1/UBE2A	3.08982413294215
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/301	253/9376	1.96992895880661	UBA52/PFN1/RPS27A/ACTG1/VDAC1/MYL12B/SKP1/MYL12A/ARPC3/CDC42/RHOA/ARPC2/ARPC5/RAC1/CCL5/CYCS	2.84824221093466
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/301	157/9376	2.18244916097086	VDAC1/CALM1/CCNE1/VDAC2/SLC25A5/CALM2/SLC25A6/PPP1CA/CDK1/CCNB1/TGFB1	2.72104651133271
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/301	250/9376	1.86897009966777	CAV1/ARPC3/CDC42/RHOA/ARPC2/RAB11A/CLTA/CAPZB/ARPC5/VPS29/SNX3/SNX2/CHMP4B/CLTB/ARF4	2.53618058936955
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/301	142/9376	2.19362687754434	CAV1/GSTO1/ACTG1/TXN/CALM1/GSTP1/RHOA/CALM2/RAC1/SUMO2	2.61013755695007
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/301	85/9376	2.56525307797538	NME1/IMPDH2/AK2/UPP1/TYMS/RRM2/GUK1	2.64002699962437
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/301	155/9376	2.00964526845997	ACTG1/TUBA1C/TUBA1B/TUBB4B/RAC1/SEC61B/SEC61G/TUBB6/CTSS/TUBB	2.30829452555935
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/301	93/9376	2.34458614653663	ACTG1/MYL12B/MYL12A/CDC42/RHOA/CSNK2B/RAC1	2.37318448564584
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/301	158/9376	1.97148744690693	SKP1/ANAPC11/CCNE1/YWHAE/CDK1/YWHAQ/PTTG1/CDC20/CCNB1/TGFB1	2.24281242791267
NA	NA	hsa04517	IgSF CAM signaling	16/301	299/9376	1.66686296514406	DYNLL1/ACTG1/MYL12B/MYL12A/ARPC3/TUBA1C/CDC42/RHOA/ARPC2/MYL6/TUBA1B/TUBB4B/ARPC5/RAC1/TUBB6/TUBB	2.13425641133434
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/301	232/9376	1.74544621377019	PFN1/ACTG1/CFL1/TMSB4X/MYL12B/MYL12A/ARPC3/CDC42/RHOA/ARPC2/ARPC5/PPP1CA/RAC1	2.09381239361486
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/301	82/9376	2.27923182886314	GSTO1/GSTP1/NME1/IMPDH2/UPP1/RRM2	2.11885100103494
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/301	107/9376	2.03781786568137	LDHA/PKM/CALM1/PYGL/CALM2/PRMT1/PGAM1	1.96626550175838
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/301	47/9376	2.65102141796847	LDHA/PKM/MDH1/MDH2	2.0664726360235
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/301	205/9376	1.67143667449964	PKM/CDC42/RHOA/RANBP1/CCNE1/YWHAE/RAC1/CDK1/YWHAQ/PSMC1/CDC20	1.77018726514894
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/301	89/9376	2.09996640412109	TUBA1C/TUBA1B/TUBB4B/CDK1/TUBB6/TUBB	1.89881332419233
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/301	30/9376	3.11495016611296	SDHB/MDH1/MDH2	2.1129705637766
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/301	31/9376	3.01446790268996	GCSH/MDH1/MDH2	2.04595988933677
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/301	31/9376	3.01446790268996	SRP9/SEC61B/SEC61G	2.04595988933677
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/301	168/9376	1.6687233032748	FTH1/VDAC1/PPIA/PYGL/VDAC2/SLC25A5/SLC25A6/CHMP4B/HMGB1	1.5928101414769
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/301	75/9376	2.0766334440753	CCNE1/CDK1/CYCS/CCNB1/RRM2	1.70482280060155
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/301	54/9376	2.307370493417	LDHA/SMS/MDH1/MDH2	1.7546341542711
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/301	98/9376	1.90711234659977	CFL1/ARPC3/CDC42/ARPC2/ARPC5/RAC1	1.6439647495438
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/301	35/9376	2.66995728523968	ALDOA/TPI1/AKR1B1	1.80255393387675
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	11/301	224/9376	1.5296630280019	VDAC1/RAN/ANAPC11/RANBP1/CCNE1/VDAC2/SLC25A5/SLC25A6/PTTG1/CDC20/TGFB1	1.46120527573499
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/301	149/9376	1.67245646502709	NDUFB3/NDUFA11/NDUFB6/NDUFA12/NDUFB4/NDUFS5/MT-ND5/NDUFA6	1.50685899983992
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/301	59/9376	2.11183062109353	NME1/UPP1/TYMS/RRM2	1.56017084535942
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/301	204/9376	1.52693635593772	RPS6/CAV1/ACTG1/CDC42/RHOA/PPP1CA/RAC1/EIF4B/PDCD4/TGFB1	1.38575608260694
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/301	20/9376	3.11495016611296	UGP2/NANS	1.72431100146111
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/301	110/9376	1.6990637269707	GAPDH/LDHA/RPS6/ALDOA/ENO1/PGK1	1.34311293555102
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/301	63/9376	1.97774613721458	PTGES3/HPGD/GPX4/CYP2J2	1.41806830813693
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/301	42/9376	2.2249644043664	FTH1/GPX4/VDAC2	1.44897130528779
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/301	138/9376	1.58004718570947	ACTG1/ARPC3/CDC42/RHOA/ARPC2/ARPC5/RAC1	1.25014232049775
NA	NA	hsa04382	Cornified envelope formation	10/301	217/9376	1.43546090604284	KRT19/KRT8/S100A11/S100A10/KRT18/S100A9/KRT23/S100A6/S100A13/KRT10	1.18195400999431
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/301	166/9376	1.501180802946	VDAC1/CALM1/RHOA/VDAC2/SLC25A5/CALM2/SLC25A6/PPP1CA	1.18649039177449
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/301	116/9376	1.61118112040325	ACTG1/MYL12B/MYL12A/CDC42/RHOA/RAC1	1.2062546504522
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/301	70/9376	1.77997152349312	CAV1/ACTG1/RAC1/CYCS	1.19286641728
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/301	120/9376	1.55747508305648	CALM1/CDC42/RHOA/YWHAE/CALM2/RAC1	1.11930895953162
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/301	173/9376	1.44043938317362	ACTG1/VDAC1/RAB11A/SLC25A5/SLC25A6/MX1/CCL5/CYCS	1.06485397261128
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/301	73/9376	1.70682200882902	RAN/PPIA/MX1/CHMP4B	1.10409273629013
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/301	50/9376	1.86897009966777	GYPC/TGFB1/HBA2	1.12198667419829
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/301	51/9376	1.83232362712527	ACTG1/SEC61B/SEC61G	1.08542160054795
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/301	52/9376	1.79708663429594	CYP11A1/CYP2J2/CYP19A1	1.04966722129674
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/301	29/9376	2.148241493871	CALM1/CALM2	1.12782491284453
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/301	78/9376	1.59741034159639	CFL1/CALM1/RHOA/CALM2	0.964874515456547
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/301	53/9376	1.76317933930922	RAB11A/CLTA/CLTB	1.01468739770905
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/301	31/9376	2.00964526845997	ALDOA/TALDO1	1.02542895767631
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/301	108/9376	1.44210655838563	EEF1A1/RAN/SAP18/UBE2I/SUMO2	0.841572221238902
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/301	32/9376	1.9468438538206	UGP2/AKR1B1	0.977085363781549
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/301	32/9376	1.9468438538206	LDHA/ECHS1	0.977085363781549
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/301	83/9376	1.501180802946	PRDX1/CROT/SOD1/ECH1	0.835220363530119
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/301	139/9376	1.34458280551638	KRT19/CALM1/KRT18/KRT23/CALM2/KRT10	0.745385774449244
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/301	60/9376	1.55747508305648	HSPB1/CDC42/RAC1	0.788918091263398
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/301	87/9376	1.432160995914	RHOA/RAC1/CYCS/TGFB1	0.737507229151583
NA	NA	hsa04519	Cadherin signaling	15/301	404/9376	1.15654090325976	KRT19/KRT8/ACTG1/KRT18/ARPC3/CDC42/RHOA/YWHAE/ARPC2/KRT23/ARPC5/PPP1CA/RAC1/YWHAQ/KRT10	0.585759653540009
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/301	36/9376	1.73052787006275	UGP2/AKR1B1	0.799760905076517
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/301	36/9376	1.73052787006275	UGP2/PYGL	0.799760905076517
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/301	203/9376	1.22756656792629	CAV1/ACTG1/MYL12B/MYL12A/CDC42/RHOA/PPP1CA/RAC1	0.596961538594733
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/301	37/9376	1.68375684654754	UGP2/NANS	0.758923378656247
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/301	37/9376	1.68375684654754	TFG/TPM3	0.758923378656247
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/301	205/9376	1.21559030872701	CCNE1/PSMD8/ISG15/RAC1/CYCS/PSMD4/PSMC1/PSMD14	0.568386019846887
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/301	39/9376	1.59741034159639	GCSH/TYMS	0.680842926086964
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/301	181/9376	1.20467685982269	CALM1/RHOA/CALM2/CYCS/CEBPB/CTSS/TGFB1	0.50638138834114
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/301	67/9376	1.39475380572222	CALM1/CALM2/PPP1CA	0.590551505454109
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/301	154/9376	1.21361694783622	ACTG1/CALM1/RHOA/MYL6/CALM2/PPP1CA	0.486775908707562
Organismal Systems	Immune system	hsa04611	Platelet activation	5/301	126/9376	1.23609133575911	ACTG1/MYL12B/MYL12A/RHOA/PPP1CA	0.485892308808351
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/301	41/9376	1.51948788590876	GCSH/PGAM1	0.607093748706051
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/301	214/9376	1.16446735181793	CFL1/CALM1/SKP1/CALM2/RAC1/CDK1/CYCS/CCNB1	0.443238025708193
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/301	69/9376	1.35432615917955	CALM1/CALM2/PPP1CA	0.537982903080254
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/301	15/9376	2.0766334440753	AK2	0.759972613884754
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/301	216/9376	1.1536852467085	CALM1/CDC42/RHOA/CYP2J2/CALM2/RAC1/CCL5/CYCS	0.416156695656683
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/301	70/9376	1.33497864261984	CDC42/RAC1/TGFB1	0.512306874355742
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/301	157/9376	1.19042681507502	RAC1/CEBPB/CD24/UQCRFS1/TGFB1/RAB17	0.438209301445679
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/301	128/9376	1.21677740863787	NME1/IMPDH2/AK2/RRM2/GUK1	0.449718407222954
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/301	99/9376	1.258565723682	CALM1/CYP2J2/CALM2/PPP1CA	0.471010231316471
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/301	99/9376	1.258565723682	KRT19/KRT18/KRT23/KRT10	0.471010231316471
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/301	99/9376	1.258565723682	ACTG1/TPM4/TPM3/TGFB1	0.471010231316471
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/301	187/9376	1.16602412635244	VDAC1/TXN/RHOA/YWHAE/VDAC2/TXNIP/CCL5	0.417641310869815
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/301	71/9376	1.3161761265266	CDC42/RAC1/CCL5	0.487018691355973
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/301	71/9376	1.3161761265266	LDHA/PKM/PGAM1	0.487018691355973
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/301	16/9376	1.9468438538206	MIF	0.690312917983493
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/301	44/9376	1.41588643914225	DYNLL1/RAB11A	0.503569365236131
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/301	103/9376	1.20968938489824	PRDX1/HSPB1/SERPINB9/TGFB1	0.389700082150855
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/301	134/9376	1.16229483810185	CALM1/RHOA/MYL6/CALM2/PPP1CA	0.344603507266092
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/301	75/9376	1.24598006644518	GSTO1/GSTP1/CYCS	0.389503435990143
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/301	195/9376	1.11818723911747	ACTG1/VDAC1/VDAC2/SLC25A5/SLC25A6/RAC1/HMGB1	0.30373054447493
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/301	105/9376	1.18664768232875	UBA52/RPS27A/CSNK2B/BNIP3L	0.350267247562708
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/301	105/9376	1.18664768232875	ACTG1/TPM4/TPM3/TGFB1	0.350267247562708
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/301	46/9376	1.35432615917955	FTH1/BLVRA	0.438719440956887
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/301	76/9376	1.22958559188669	ACTG1/CALM1/CALM2	0.365978455959177
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/301	136/9376	1.14520226695329	EIF3H/CCNE1/CSNK2B/MX1/CYCS	0.310636464392919
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/301	18/9376	1.73052787006275	PRDX1	0.564972215573879
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/301	137/9376	1.1368431263186	ACTG1/TUBA1C/TUBA1B/CYCS/CTSS	0.293843681594016
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/301	77/9376	1.21361694783622	CDC42/RAC1/TGFB1	0.342774505860456
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/301	138/9376	1.12860513264962	RPS6/CALM1/PYGL/CALM2/PPP1CA	0.277175241807047
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/301	19/9376	1.63944745584892	GCSH	0.508111376379146
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/301	110/9376	1.1327091513138	SKP1/RHOA/INHBA/TGFB1	0.254974433544076
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/301	174/9376	1.0741207469355	SKP1/SEC61B/SEC61G/DNAJA1/UBE2J1/BAG2	0.17972929302634
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/301	82/9376	1.13961591443157	PSME2/PSME1/CTSS	0.231252313598733
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/301	52/9376	1.19805775619729	VDAC1/VDAC2	0.260818241906051
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/301	212/9376	1.02852128126371	PFN1/ACTG1/CALM1/CDC42/RHOA/CALM2/RAC1	0.0764962227203308
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/301	23/9376	1.35432615917955	SSBP1	0.30983982349369
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/301	23/9376	1.35432615917955	MDH1	0.30983982349369
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/301	183/9376	1.02129513643048	RAN/NOP10/CSNK2B/SNU13/NHP2/FBL	0.0529813366449073
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/301	56/9376	1.1124822021832	EEF1A1/CYCS	0.153750110604934
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/301	184/9376	1.01574461938466	CFL1/MYL12B/MYL12A/CDC42/RHOA/RAC1	0.0392809189394187
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/301	154/9376	1.01134745653018	CALM1/TPM4/CALM2/PPP1CA/TPM3	0.0258578194284163
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/301	156/9376	0.998381463497742	YWHAE/MX1/EIF3E/YWHAQ/CYCS	-0.00371248669708904
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/301	157/9376	0.992022345895846	ACTG1/YWHAE/PPP1CA/YWHAQ/TGFB1	-0.0183581405317279
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/301	93/9376	1.00482263422999	CALM1/CDC42/CALM2	0.00851191332294124
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/301	93/9376	1.00482263422999	CCNE1/CKS1B/CYCS	0.00851191332294124
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/301	27/9376	1.1536852467085	ECHS1	0.145638785939971
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/301	61/9376	1.02129513643048	FTH1/MT2A	0.0303878157034277
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/301	193/9376	0.968378289983303	CDC42/RHOA/PPBP/PF4/RAC1/CCL5	-0.0808383207185006
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/301	28/9376	1.1124822021832	ECHS1	0.108554802952481
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/301	28/9376	1.1124822021832	AKR1B1	0.108554802952481
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/301	196/9376	0.953556173299885	UBA52/RPS27A/CALM1/CALM2/RAC1/CYCS	-0.119668613730961
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/301	98/9376	0.953556173299885	CALM1/CYP11A1/CALM2	-0.0841704053694226
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/301	30/9376	1.03831672203765	CYP2J2	0.0382808574231177
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/301	30/9376	1.03831672203765	TYMS	0.0382808574231177
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/301	233/9376	0.935821938317197	ENO1/ACTG1/PDLIM2/TPM4/CAPZB/CSRP2/TPM3	-0.180661564191159
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/301	100/9376	0.934485049833887	PPBP/PF4/CCL5	-0.119951480930506
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/301	66/9376	0.943924292761502	CYP11A1/CYP19A1	-0.0832563670318363
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/301	101/9376	0.925232722607809	CDC42/RAC1/TGFB1	-0.137581760767909
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/301	31/9376	1.00482263422999	ECHS1	0.00489802601586181
NA	NA	hsa04981	Folate transport and metabolism	1/301	31/9376	1.00482263422999	TYMS	0.00489802601586181
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/301	102/9376	0.916161813562634	RHOA/RAB11A/RAC1	-0.155043650204923
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/301	32/9376	0.973421926910299	CYCS	-0.0274269575798329
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/301	69/9376	0.902884106119698	CALM1/CALM2	-0.147453664290375
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/301	105/9376	0.889985761746559	CALM1/RHOA/CALM2	-0.206455199148251
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/301	70/9376	0.889985761746559	GSTO1/GSTP1	-0.168252668568519
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/301	34/9376	0.916161813562634	SKP1	-0.0891881121737099
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/301	143/9376	0.871314731779848	SSB/SNRPD1/SNRPB/SNRPD3	-0.28240410297937
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/301	178/9376	0.874986001717123	SKP1/RHOA/CSNK2B/CACYBP/RAC1	-0.306667330675446
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/301	73/9376	0.853411004414509	GSTO1/GSTP1	-0.228979634511011
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/301	180/9376	0.865263935031377	SRSF3/PPP1CA/CCL5/CYCS/SRSF9	-0.332403968291016
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/301	110/9376	0.849531863485352	ANAPC11/CDK1/CCNB1	-0.289094817459397
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/301	36/9376	0.865263935031377	SSBP1	-0.14750516945575
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/301	75/9376	0.830653377630122	GPX3/GPX1	-0.268156246315562
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/301	37/9376	0.841878423273772	MIF	-0.175504145740466
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/301	37/9376	0.841878423273772	HBA2	-0.175504145740466
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/301	76/9376	0.819723727924462	CALM1/CALM2	-0.287375314618364
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/301	38/9376	0.819723727924462	UGP2	-0.202791151560922
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/301	78/9376	0.798705170798194	ENO1/LSM3	-0.32511029231767
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/301	78/9376	0.798705170798194	EEF1A1/TGFB1	-0.32511029231767
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/301	79/9376	0.788594978762774	GSTO1/GSTP1	-0.343639436060336
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/301	79/9376	0.788594978762774	CLTA/CLTB	-0.343639436060336
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/301	117/9376	0.798705170798194	ACTG1/MORF4L2/MORF4L1	-0.399014866539243
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/301	154/9376	0.809077965224145	UGP2/NME1/AK2/RDH13	-0.435060269850729
NA	NA	hsa04518	Integrin signaling	4/301	154/9376	0.809077965224145	ACTG1/CDC42/RAC1/TGFB1	-0.435060269850729
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/301	226/9376	0.82697792020698	CALM1/RHOA/CALM2/CRH/PPP1CA/RAC1	-0.479502382938895
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/301	41/9376	0.75974394295438	SSBP1	-0.280772572908039
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/301	227/9376	0.823334845668623	CALM1/RHOA/CALM2/RAC1/CCL5/CYCS	-0.490707370362128
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/301	42/9376	0.741654801455466	ECHS1	-0.305588291558177
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/301	83/9376	0.750590401473002	SKP1/CSNK2B	-0.415642367634867
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/301	43/9376	0.724407015375106	ECHS1	-0.32986582378569
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/301	44/9376	0.707943219571127	HMGB1	-0.353632226712664
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/301	163/9376	0.764404948739376	CCNE1/YWHAQ/CYCS/TGFB1	-0.552592516911437
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/301	47/9376	0.662755354492119	PKM	-0.422106475423562
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/301	48/9376	0.648947951273533	ECHS1	-0.444061816382755
NA	NA	hsa03272	Virion - Hepatitis viruses	1/301	48/9376	0.648947951273533	CHMP4B	-0.444061816382755
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/301	170/9376	0.732929450850107	GSTO1/ACTG1/GSTP1/TGFB1	-0.63997136751011
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/301	93/9376	0.669881756153324	CALM1/CALM2	-0.582656229757783
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/301	50/9376	0.622990033222591	SMS	-0.486783329974087
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/301	50/9376	0.622990033222591	TGFB1	-0.486783329974087
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/301	133/9376	0.702620338220968	PRMT1/CCNB1/TGFB1	-0.629036978070739
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/301	133/9376	0.702620338220968	CALM1/CALM2/PPP1CA	-0.629036978070739
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/301	94/9376	0.662755354492119	S100A9/CEBPB	-0.598458137887102
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/301	95/9376	0.65577898233957	CCL5/TGFB1	-0.614111697277179
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/301	97/9376	0.642257766208857	CALM1/CALM2	-0.644987151551947
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/301	98/9376	0.635704115533256	CALM1/CALM2	-0.660215457007165
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/301	254/9376	0.735814999869202	VDAC1/CALM1/VDAC2/SLC25A5/CALM2/SLC25A6	-0.77736601319103
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/301	140/9376	0.667489321309919	RPS6/CALM1/CALM2	-0.721893650983037
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/301	101/9376	0.616821815071873	CALM1/CALM2	-0.705098957846621
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/301	57/9376	0.546482485282975	ECHS1	-0.625449723930531
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/301	103/9376	0.604844692449118	SAP18/PPP1CA	-0.734381742259671
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/301	103/9376	0.604844692449118	CCL5/TGFB1	-0.734381742259671
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/301	298/9376	0.731699703449352	CSH1/PPBP/CSH2/PF4/INHBA/CCL5/TGFB1	-0.85719526749609
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/301	105/9376	0.593323841164373	CSNK2B/UBE2I	-0.763177645859211
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/301	106/9376	0.587726446436407	GSTP1/CCNE1	-0.777399239367078
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/301	60/9376	0.519158361018826	CRH	-0.680469279353531
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/301	191/9376	0.652345584526274	CALM1/CALM2/CRH/PPP1CA	-0.884036959194386
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/301	62/9376	0.502411317114993	SOD1	-0.715885871383647
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/301	109/9376	0.571550489195038	RAC1/CCL5	-0.819386657631242
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/301	109/9376	0.571550489195038	PYGL/PPP1CA	-0.819386657631242
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/301	63/9376	0.494436534303644	ECHS1	-0.733240972445322
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/301	155/9376	0.602893580537992	CYP11A1/CCNE1/CRH	-0.907881810318183
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/301	112/9376	0.556241101091599	CYCS/TGFB1	-0.860403924329002
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/301	65/9376	0.479223102478916	AKR1B1	-0.767283385341193
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/301	65/9376	0.479223102478916	CYP11A1	-0.767283385341193
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/301	65/9376	0.479223102478916	KISS1	-0.767283385341193
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/301	66/9376	0.471962146380751	TGFB1	-0.783985000147184
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/301	238/9376	0.654401295401882	CALM1/CDC42/RHOA/CALM2/RAC1	-0.983514068896776
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/301	158/9376	0.59144623407208	RPS6/RHOA/EIF4B	-0.943202577255166
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/301	115/9376	0.541730463671819	NACA/RHOA	-0.900505843801252
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/301	68/9376	0.458080906781317	RDH13	-0.816782249124906
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/301	69/9376	0.451442053059849	RAC1	-0.832890231661004
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/301	119/9376	0.523521036321505	CCL5/CEBPB	-0.952637447845091
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/301	362/9376	0.688386777041537	RPS6/CSH1/CCNE1/YWHAE/CSH2/RAC1/YWHAQ/EIF4B	-1.10117655352611
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/301	72/9376	0.432631967515688	ISG15	-0.88011987613165
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/301	122/9376	0.510647568215239	CDC42/RHOA	-0.990791991913932
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/301	122/9376	0.510647568215239	CSH1/CSH2	-0.990791991913932
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/301	250/9376	0.622990033222591	CLTA/VPS29/CTSS/CLTB/AP3S1	-1.10034322251742
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/301	169/9376	0.552949733629519	UBA52/RPS27A/HMGB1	-1.06803677779669
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/301	125/9376	0.498392026578073	RHOA/RAC1	-1.02818358598776
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/301	76/9376	0.409861863962231	PLIN2	-0.940729085195905
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/301	77/9376	0.404538982612072	TGFB1	-0.955489993007503
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/301	78/9376	0.399352585399097	TPI1	-0.970102696204778
NA	NA	hsa04081	Hormone signaling	4/301	219/9376	0.568940669609672	CSH1/RHOA/CSH2/CRH	-1.17551471353107
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/301	80/9376	0.38936877076412	RPS6	-0.998898857893411
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/301	83/9376	0.375295200736501	CCL5	-1.04107373321736
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/301	86/9376	0.362203507687553	ACTG1	-1.08210415393704
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/301	142/9376	0.438725375508867	RAC1/TGFB1	-1.22735505098656
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/301	90/9376	0.346105574012551	CSNK2B	-1.13516794641079
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/301	91/9376	0.342302216056369	RAC1	-1.14815808888987
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/301	150/9376	0.415326688815061	CCNE1/TGFB1	-1.31461245748849
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	6/301	333/9376	0.561252282182515	PKM/CDC42/CCNE1/MX1/ISG15/PSMC1	-1.48465754922149
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/301	99/9376	0.314641430920501	RAC1	-1.24846748269647
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/301	100/9376	0.311495016611296	CD24	-1.26058544158408
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/301	109/9376	0.285775244597519	TGFB1	-1.3659164507557
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/301	168/9376	0.370827400727733	CSH1/CSH2	-1.49860561453836
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/301	115/9376	0.270865231835909	CYP2J2	-1.43275969184264
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/301	122/9376	0.255323784107619	ACTG1	-1.50774612191866
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/301	130/9376	0.239611551239458	TGFB1	-1.58992197339838
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/301	133/9376	0.234206779406989	RAC1	-1.61985608036242
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/301	300/9376	0.415326688815061	HSPB1/CDC42/RAC1/TGFB1	-1.87444293219494
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/301	201/9376	0.309945290160493	HPGD/CEBPB	-1.8010430168403
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/301	144/9376	0.216315983757844	INHBA	-1.72591699968823
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/301	149/9376	0.209057058128386	RHOA	-1.77236676618328
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/301	370/9376	0.420939211636886	CSH1/CSH2/CRH/KISS1/NPB	-2.06968673946389
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/301	323/9376	0.385752342552688	RHOA/CCNE1/UBE2I/PDCD4	-2.04594558592892
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/301	217/9376	0.287092181208567	GSTO1/PTGES3	-1.93501699804468
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/301	449/9376	0.138750564192114	CALM1/CALM2	-3.40600218845278