ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 73/436 175/18639 0.417142857142857 17.8328571428571 6.0187027770324e-73 3.83993237174667e-70 GO:0045296 cadherin binding 42/436 334/18639 0.125748502994012 5.37574850299401 4.44418386701612e-19 1.41769465357814e-16 GO:0019843 rRNA binding 18/436 65/18639 0.276923076923077 11.8384615384615 5.6351425217819e-15 1.19840697629895e-12 GO:0016209 antioxidant activity 16/436 86/18639 0.186046511627907 7.95348837209302 1.31991517605171e-10 2.10526470580249e-08 GO:0009055 electron transfer activity 18/436 116/18639 0.155172413793103 6.63362068965517 2.12749651963337e-10 2.71468555905218e-08 GO:0180051 translation factor activity 15/436 84/18639 0.178571428571429 7.63392857142857 9.1663993499637e-10 9.7469379754614e-08 GO:0004601 peroxidase activity 12/436 57/18639 0.210526315789474 9 6.29984231769215e-09 5.14084404445666e-07 GO:0043021 ribonucleoprotein complex binding 20/436 177/18639 0.112994350282486 4.83050847457627 6.55373829572273e-09 5.14084404445666e-07 GO:0008135 translation factor activity, RNA binding 14/436 83/18639 0.168674698795181 7.21084337349398 7.25197435738401e-09 5.14084404445666e-07 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 12/436 59/18639 0.203389830508475 8.69491525423729 9.55833898249197e-09 6.09822027082987e-07 GO:0003743 translation initiation factor activity 11/436 51/18639 0.215686274509804 9.22058823529412 2.07587171316847e-08 1.20400559363771e-06 GO:0048306 calcium-dependent protein binding 13/436 80/18639 0.1625 6.946875 3.98946704361316e-08 2.0750403165375e-06 GO:0048027 mRNA 5'-UTR binding 8/436 24/18639 0.333333333333333 14.25 4.45196328972918e-08 2.0750403165375e-06 GO:0044389 ubiquitin-like protein ligase binding 26/436 322/18639 0.0807453416149068 3.45186335403727 4.55338000494122e-08 2.0750403165375e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 12/436 68/18639 0.176470588235294 7.54411764705882 5.14029862007033e-08 2.18634034640325e-06 GO:0051082 unfolded protein binding 15/436 121/18639 0.12396694214876 5.2995867768595 1.51760504885595e-07 6.05145013231309e-06 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/436 15/18639 0.4 17.1 6.6246236727129e-07 2.48618229599461e-05 GO:0031625 ubiquitin protein ligase binding 23/436 302/18639 0.076158940397351 3.25579470198676 7.69345774742346e-07 2.72690335714231e-05 GO:0055106 ubiquitin-protein transferase regulator activity 8/436 36/18639 0.222222222222222 9.5 1.43172084218606e-06 4.80756788060373e-05 GO:0043022 ribosome binding 13/436 112/18639 0.116071428571429 4.96205357142857 2.18382388706741e-06 6.96639819974505e-05 GO:0098641 cadherin binding involved in cell-cell adhesion 6/436 18/18639 0.333333333333333 14.25 2.31472198574558e-06 7.03234584240801e-05 GO:1990948 ubiquitin ligase inhibitor activity 5/436 11/18639 0.454545454545455 19.4318181818182 2.81546090822088e-06 8.16483663384055e-05 GO:0043024 ribosomal small subunit binding 6/436 20/18639 0.3 12.825 4.64452857925707e-06 0.00012583926935737 GO:0004859 phospholipase inhibitor activity 5/436 12/18639 0.416666666666667 17.8125 4.73376561845908e-06 0.00012583926935737 GO:0004857 enzyme inhibitor activity 26/436 416/18639 0.0625 2.671875 5.96779503986693e-06 0.000152298129417404 GO:0031386 protein tag activity 5/436 15/18639 0.333333333333333 14.25 1.69350406446034e-05 0.000400168738194703 GO:0141047 molecular tag activity 5/436 15/18639 0.333333333333333 14.25 1.69350406446034e-05 0.000400168738194703 GO:0022853 active monoatomic ion transmembrane transporter activity 12/436 118/18639 0.101694915254237 4.34745762711864 2.0998944896995e-05 0.000478475958724387 GO:0055102 lipase inhibitor activity 5/436 16/18639 0.3125 13.359375 2.41604930569233e-05 0.000531530847252314 GO:0015078 proton transmembrane transporter activity 15/436 185/18639 0.0810810810810811 3.46621621621622 3.12996713925793e-05 0.000665639678282187 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/436 41/18639 0.170731707317073 7.29878048780488 4.12749427063724e-05 0.0008229191702083 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/436 41/18639 0.170731707317073 7.29878048780488 4.12749427063724e-05 0.0008229191702083 GO:0031720 haptoglobin binding 4/436 10/18639 0.4 17.1 5.54541942828457e-05 0.00107211442280168 GO:0003954 NADH dehydrogenase activity 7/436 44/18639 0.159090909090909 6.80113636363636 6.62291960084506e-05 0.00124277138392328 GO:0070034 telomerase RNA binding 5/436 22/18639 0.227272727272727 9.71590909090909 0.000129715207067019 0.00236452291739308 GO:0004602 glutathione peroxidase activity 5/436 23/18639 0.217391304347826 9.29347826086956 0.000162581501947399 0.00288130550673446 GO:0019855 calcium channel inhibitor activity 4/436 13/18639 0.307692307692308 13.1538461538462 0.00017855051411968 0.00307878994617179 GO:0005344 oxygen carrier activity 4/436 14/18639 0.285714285714286 12.2142857142857 0.000245366380613355 0.00401394232900822 GO:0044548 S100 protein binding 4/436 14/18639 0.285714285714286 12.2142857142857 0.000245366380613355 0.00401394232900822 GO:0005200 structural constituent of cytoskeleton 10/436 112/18639 0.0892857142857143 3.81696428571429 0.000299052763762624 0.00476989158201385 GO:0015036 disulfide oxidoreductase activity 6/436 40/18639 0.15 6.4125 0.000309595974529746 0.00481761540853605 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/436 58/18639 0.120689655172414 5.15948275862069 0.000392314890323286 0.00595945000062515 GO:0051015 actin filament binding 14/436 209/18639 0.0669856459330144 2.86363636363636 0.000423852627290024 0.00628879014444268 GO:0015399 primary active transmembrane transporter activity 12/436 166/18639 0.072289156626506 3.09036144578313 0.000547985736062931 0.0079457931729125 GO:0019825 oxygen binding 5/436 34/18639 0.147058823529412 6.28676470588235 0.00108826712292379 0.0154292094316751 GO:0061631 ubiquitin conjugating enzyme activity 5/436 35/18639 0.142857142857143 6.10714285714286 0.00124556266622813 0.016997874959574 GO:0019207 kinase regulator activity 16/436 287/18639 0.0557491289198606 2.38327526132404 0.00125219455031345 0.016997874959574 GO:0044325 transmembrane transporter binding 10/436 136/18639 0.0735294117647059 3.14338235294118 0.0013696196236259 0.0182045274973609 GO:0140517 protein-RNA adaptor activity 4/436 22/18639 0.181818181818182 7.77272727272727 0.00154608514176156 0.0201306596008954 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/436 54/18639 0.111111111111111 4.75 0.00158226804767003 0.0201897402882696 GO:0098632 cell-cell adhesion mediator activity 6/436 55/18639 0.109090909090909 4.66363636363636 0.00174158449950142 0.021786880601606 GO:0050786 RAGE receptor binding 3/436 11/18639 0.272727272727273 11.6590909090909 0.00182356684518042 0.0218307867673937 GO:0070990 snRNP binding 3/436 11/18639 0.272727272727273 11.6590909090909 0.00182356684518042 0.0218307867673937 GO:0003779 actin binding 21/436 443/18639 0.0474040632054176 2.0265237020316 0.00184774684238129 0.0218307867673937 GO:0098631 cell adhesion mediator activity 7/436 76/18639 0.0921052631578947 3.9375 0.00199142368701037 0.0231005147693203 GO:0001786 phosphatidylserine binding 6/436 59/18639 0.101694915254237 4.34745762711864 0.00250322636743966 0.0285189004004733 GO:0061134 peptidase regulator activity 13/436 226/18639 0.0575221238938053 2.45907079646018 0.00265554451048444 0.0297234631173522 GO:0019887 protein kinase regulator activity 14/436 255/18639 0.0549019607843137 2.34705882352941 0.00283702116816213 0.0312072328497834 GO:0008200 ion channel inhibitor activity 5/436 43/18639 0.116279069767442 4.97093023255814 0.00317005989573946 0.0342796307369793 GO:0016248 channel inhibitor activity 5/436 44/18639 0.113636363636364 4.85795454545454 0.00350901033983303 0.0373124766135579 GO:0032036 myosin heavy chain binding 3/436 14/18639 0.214285714285714 9.16071428571428 0.00381835290752329 0.0398566205942174 GO:0141110 transporter inhibitor activity 5/436 45/18639 0.111111111111111 4.75 0.00387321391354464 0.0398566205942174 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/436 88/18639 0.0795454545454545 3.40056818181818 0.00455710929890208 0.046042330589597 GO:0004129 cytochrome-c oxidase activity 3/436 15/18639 0.2 8.55 0.00469083305379907 0.046042330589597 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/436 15/18639 0.2 8.55 0.00469083305379907 0.046042330589597 GO:0003727 single-stranded RNA binding 7/436 89/18639 0.0786516853932584 3.3623595505618 0.00484917116473867 0.0468753212591405 GO:0072341 modified amino acid binding 7/436 91/18639 0.0769230769230769 3.28846153846154 0.00547530663682609 0.0517156911219066 GO:0008142 oxysterol binding 3/436 16/18639 0.1875 8.015625 0.00567413538955088 0.0517156911219066 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/436 16/18639 0.1875 8.015625 0.00567413538955088 0.0517156911219066 GO:0043023 ribosomal large subunit binding 3/436 16/18639 0.1875 8.015625 0.00567413538955088 0.0517156911219066 GO:0031369 translation initiation factor binding 4/436 32/18639 0.125 5.34375 0.00632381941445169 0.0568253068509884 GO:0140311 protein sequestering activity 4/436 33/18639 0.121212121212121 5.18181818181818 0.00706556202320423 0.0626087301500597 GO:0005246 calcium channel regulator activity 5/436 53/18639 0.0943396226415094 4.03301886792453 0.00781600168206999 0.0653283653540881 GO:0005544 calcium-dependent phospholipid binding 5/436 53/18639 0.0943396226415094 4.03301886792453 0.00781600168206999 0.0653283653540881 GO:0016860 intramolecular oxidoreductase activity 5/436 53/18639 0.0943396226415094 4.03301886792453 0.00781600168206999 0.0653283653540881 GO:0015035 protein-disulfide reductase activity 4/436 34/18639 0.117647058823529 5.02941176470588 0.00786253467657497 0.0653283653540881 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/436 122/18639 0.0655737704918033 2.80327868852459 0.00797756808354559 0.0653283653540881 GO:0003746 translation elongation factor activity 3/436 18/18639 0.166666666666667 7.125 0.00798685344454369 0.0653283653540881 GO:0019209 kinase activator activity 9/436 148/18639 0.0608108108108108 2.59966216216216 0.0081391782325239 0.0653480983972972 GO:0044183 protein folding chaperone 6/436 75/18639 0.08 3.42 0.00819411892129118 0.0653480983972972 GO:0003925 G protein activity 5/436 54/18639 0.0925925925925926 3.95833333333333 0.00845209695088632 0.0665733068477219 GO:0140313 molecular sequestering activity 5/436 55/18639 0.0909090909090909 3.88636363636364 0.0091231481960248 0.0709825432812661 GO:0008301 DNA binding, bending 3/436 19/18639 0.157894736842105 6.75 0.00932202387129552 0.0716560389142957 GO:0016835 carbon-oxygen lyase activity 6/436 79/18639 0.0759493670886076 3.24683544303797 0.0104685987488726 0.0793646985384403 GO:0016504 peptidase activator activity 5/436 57/18639 0.087719298245614 3.75 0.0105736667331778 0.0793646985384403 GO:0061135 endopeptidase regulator activity 10/436 184/18639 0.0543478260869565 2.32336956521739 0.0115443855314755 0.0856432321986206 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/436 132/18639 0.0606060606060606 2.59090909090909 0.0124969199684842 0.0916440797688842 GO:0000217 DNA secondary structure binding 4/436 39/18639 0.102564102564103 4.38461538461538 0.0127293371265171 0.0922876941672492 GO:0051087 protein-folding chaperone binding 8/436 134/18639 0.0597014925373134 2.55223880597015 0.0135890334322752 0.0974135205594563 GO:0140662 ATP-dependent protein folding chaperone 4/436 40/18639 0.1 4.275 0.0138887580233052 0.0984558624318747 GO:0061133 endopeptidase activator activity 3/436 22/18639 0.136363636363636 5.82954545454545 0.0140690885512281 0.0986382252272915 GO:0017134 fibroblast growth factor binding 3/436 23/18639 0.130434782608696 5.57608695652174 0.0159038494740224 0.110289738743764 GO:0008307 structural constituent of muscle 4/436 42/18639 0.0952380952380952 4.07142857142857 0.016403359630677 0.111333440897574 GO:0042056 chemoattractant activity 4/436 42/18639 0.0952380952380952 4.07142857142857 0.016403359630677 0.111333440897574 GO:0030295 protein kinase activator activity 8/436 139/18639 0.0575539568345324 2.46043165467626 0.0166222196862697 0.111631327998317 GO:0005525 GTP binding 16/436 378/18639 0.0423280423280423 1.80952380952381 0.0168394531789838 0.111912199251996 GO:0020037 heme binding 8/436 142/18639 0.0563380281690141 2.40845070422535 0.0186609032005298 0.122738724143691 GO:0001094 TFIID-class transcription factor complex binding 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0005131 growth hormone receptor binding 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0030957 Tat protein binding 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0031996 thioesterase binding 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0140940 histone H2A methyltransferase activity 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:1990259 histone H2AQ104 methyltransferase activity 2/436 10/18639 0.2 8.55 0.0216959069702535 0.133096044682902 GO:0003924 GTPase activity 14/436 331/18639 0.0422960725075529 1.80815709969789 0.0244907928712524 0.147366242022341 GO:0005536 D-glucose binding 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0008199 ferric iron binding 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0010854 adenylate cyclase regulator activity 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0015217 ADP transmembrane transporter activity 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0032050 clathrin heavy chain binding 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0034511 U3 snoRNA binding 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0042608 T cell receptor binding 2/436 11/18639 0.181818181818182 7.77272727272727 0.0261119825536031 0.147366242022341 GO:0046906 tetrapyrrole binding 8/436 152/18639 0.0526315789473684 2.25 0.026743812831306 0.147366242022341 GO:0019001 guanyl nucleotide binding 16/436 400/18639 0.04 1.71 0.0267938621858802 0.147366242022341 GO:0032561 guanyl ribonucleotide binding 16/436 400/18639 0.04 1.71 0.0267938621858802 0.147366242022341 GO:0043539 protein serine/threonine kinase activator activity 5/436 73/18639 0.0684931506849315 2.92808219178082 0.0280886390238017 0.153167108522953 GO:0043236 laminin binding 3/436 29/18639 0.103448275862069 4.42241379310345 0.0296130741173577 0.160111366837917 GO:0010853 cyclase activator activity 2/436 12/18639 0.166666666666667 7.125 0.0308564901271381 0.161364268041919 GO:0036009 protein-glutamine N-methyltransferase activity 2/436 12/18639 0.166666666666667 7.125 0.0308564901271381 0.161364268041919 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/436 12/18639 0.166666666666667 7.125 0.0308564901271381 0.161364268041919 GO:0097371 MDM2/MDM4 family protein binding 2/436 12/18639 0.166666666666667 7.125 0.0308564901271381 0.161364268041919 GO:0030544 Hsp70 protein binding 4/436 51/18639 0.0784313725490196 3.35294117647059 0.0311248291526993 0.16144423576766 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/436 30/18639 0.1 4.275 0.0323479400755654 0.166435369098474 GO:0017022 myosin binding 5/436 76/18639 0.0657894736842105 2.8125 0.0326689286169272 0.166742211660796 GO:0051540 metal cluster binding 5/436 77/18639 0.0649350649350649 2.77597402597403 0.03429304198794 0.173642545938934 GO:0099106 ion channel regulator activity 8/436 160/18639 0.05 2.1375 0.0347560760826246 0.174601390084366 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/436 13/18639 0.153846153846154 6.57692307692308 0.0359117223434411 0.17489831187111 GO:0031432 titin binding 2/436 13/18639 0.153846153846154 6.57692307692308 0.0359117223434411 0.17489831187111 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/436 13/18639 0.153846153846154 6.57692307692308 0.0359117223434411 0.17489831187111 GO:0140666 annealing activity 2/436 13/18639 0.153846153846154 6.57692307692308 0.0359117223434411 0.17489831187111 GO:0017069 snRNA binding 4/436 54/18639 0.0740740740740741 3.16666666666667 0.0373212807261151 0.180386190176223 GO:0030515 snoRNA binding 3/436 32/18639 0.09375 4.0078125 0.0381981952136635 0.183236455235469 GO:0003713 transcription coactivator activity 11/436 256/18639 0.04296875 1.8369140625 0.0391018174443193 0.186171339772207 GO:0005347 ATP transmembrane transporter activity 2/436 14/18639 0.142857142857143 6.10714285714286 0.0412606172494274 0.193560836802461 GO:1990825 sequence-specific mRNA binding 2/436 14/18639 0.142857142857143 6.10714285714286 0.0412606172494274 0.193560836802461 GO:0016247 channel regulator activity 8/436 168/18639 0.0476190476190476 2.03571428571429 0.0442560194126046 0.205955882917384 GO:0051427 hormone receptor binding 3/436 34/18639 0.0882352941176471 3.77205882352941 0.0445484511639482 0.205955882917384 GO:0030414 peptidase inhibitor activity 8/436 169/18639 0.0473372781065089 2.02366863905325 0.0455524228223533 0.20908234360188 GO:0141108 transporter regulator activity 8/436 170/18639 0.0470588235294118 2.01176470588235 0.04687350440405 0.212154175723062 GO:0000774 adenyl-nucleotide exchange factor activity 2/436 15/18639 0.133333333333333 5.7 0.0468867378949087 0.212154175723062 GO:0004033 aldo-keto reductase (NADPH) activity 3/436 36/18639 0.0833333333333333 3.5625 0.0513876401936975 0.229267933171881 GO:0045505 dynein intermediate chain binding 3/436 36/18639 0.0833333333333333 3.5625 0.0513876401936975 0.229267933171881 GO:0005521 lamin binding 2/436 16/18639 0.125 5.34375 0.0527742525385313 0.230616254243719 GO:0017070 U6 snRNA binding 2/436 16/18639 0.125 5.34375 0.0527742525385313 0.230616254243719 GO:0097027 ubiquitin-protein transferase activator activity 2/436 16/18639 0.125 5.34375 0.0527742525385313 0.230616254243719 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/436 61/18639 0.0655737704918033 2.80327868852459 0.0543376767454394 0.235832909956397 GO:0042162 telomeric DNA binding 3/436 38/18639 0.0789473684210526 3.375 0.0587024663080942 0.252236577497619 GO:0045236 CXCR chemokine receptor binding 2/436 17/18639 0.117647058823529 5.02941176470588 0.058907915434397 0.252236577497619 GO:0016853 isomerase activity 8/436 180/18639 0.0444444444444444 1.9 0.0614661885645796 0.261436188694679 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/436 39/18639 0.0769230769230769 3.28846153846154 0.0625335604065589 0.264214645956189 GO:0000400 four-way junction DNA binding 2/436 18/18639 0.111111111111111 4.75 0.0652730481831287 0.270416913901533 GO:0000900 mRNA regulatory element binding translation repressor activity 2/436 18/18639 0.111111111111111 4.75 0.0652730481831287 0.270416913901533 GO:0008308 voltage-gated monoatomic anion channel activity 2/436 18/18639 0.111111111111111 4.75 0.0652730481831287 0.270416913901533 GO:0061791 GTPase motor activity 3/436 40/18639 0.075 3.20625 0.0664777335727686 0.271876884739913 GO:1990606 membrane scission GTPase motor activity 3/436 40/18639 0.075 3.20625 0.0664777335727686 0.271876884739913 GO:0005506 iron ion binding 7/436 154/18639 0.0454545454545455 1.94318181818182 0.0702998995447155 0.284744240999676 GO:0001530 lipopolysaccharide binding 3/436 41/18639 0.0731707317073171 3.1280487804878 0.070532838388102 0.284744240999676 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/436 19/18639 0.105263157894737 4.5 0.0718555216315796 0.284744240999676 GO:0050145 nucleoside monophosphate kinase activity 2/436 19/18639 0.105263157894737 4.5 0.0718555216315796 0.284744240999676 GO:0097001 ceramide binding 2/436 19/18639 0.105263157894737 4.5 0.0718555216315796 0.284744240999676 GO:0010851 cyclase regulator activity 2/436 20/18639 0.1 4.275 0.078641738305816 0.305935542921406 GO:0016004 phospholipase activator activity 2/436 20/18639 0.1 4.275 0.078641738305816 0.305935542921406 GO:0042288 MHC class I protein binding 2/436 20/18639 0.1 4.275 0.078641738305816 0.305935542921406 GO:0097110 scaffold protein binding 4/436 70/18639 0.0571428571428571 2.44285714285714 0.0813802749852852 0.314670396609769 GO:0019205 nucleobase-containing compound kinase activity 3/436 44/18639 0.0681818181818182 2.91477272727273 0.0833410703872721 0.31839283177892 GO:0030547 signaling receptor inhibitor activity 3/436 44/18639 0.0681818181818182 2.91477272727273 0.0833410703872721 0.31839283177892 GO:0004866 endopeptidase inhibitor activity 7/436 161/18639 0.0434782608695652 1.85869565217391 0.0844327122440993 0.32064327626033 GO:0070182 DNA polymerase binding 2/436 21/18639 0.0952380952380952 4.07142857142857 0.0856186153624156 0.321321627066007 GO:0072542 protein phosphatase activator activity 2/436 21/18639 0.0952380952380952 4.07142857142857 0.0856186153624156 0.321321627066007 GO:0031072 heat shock protein binding 6/436 131/18639 0.0458015267175573 1.95801526717557 0.0874070025938594 0.325739368995249 GO:0008009 chemokine activity 3/436 45/18639 0.0666666666666667 2.85 0.0878168831774025 0.325739368995249 GO:0048029 monosaccharide binding 4/436 74/18639 0.0540540540540541 2.31081081081081 0.0951737354567363 0.350987533071663 GO:0016829 lyase activity 8/436 200/18639 0.04 1.71 0.0983731332442966 0.358765656913315 GO:0003725 double-stranded RNA binding 4/436 75/18639 0.0533333333333333 2.28 0.0987838770952434 0.358765656913315 GO:0002020 protease binding 6/436 136/18639 0.0441176470588235 1.88602941176471 0.100092892787031 0.358765656913315 GO:0000295 adenine nucleotide transmembrane transporter activity 2/436 23/18639 0.0869565217391304 3.71739130434783 0.100094493621583 0.358765656913315 GO:0008171 O-methyltransferase activity 2/436 23/18639 0.0869565217391304 3.71739130434783 0.100094493621583 0.358765656913315 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/436 48/18639 0.0625 2.671875 0.101828744603368 0.362942676295804 GO:0051536 iron-sulfur cluster binding 4/436 76/18639 0.0526315789473684 2.25 0.102456929788483 0.363152895583624 GO:0060590 ATPase regulator activity 3/436 49/18639 0.0612244897959184 2.61734693877551 0.106685589804715 0.375024613185781 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/436 24/18639 0.0833333333333333 3.5625 0.107569755819746 0.375024613185781 GO:0060229 lipase activator activity 2/436 24/18639 0.0833333333333333 3.5625 0.107569755819746 0.375024613185781 GO:0019211 phosphatase activator activity 2/436 25/18639 0.08 3.42 0.11518816969494 0.399402457963977 GO:0022804 active transmembrane transporter activity 15/436 457/18639 0.0328227571115974 1.40317286652079 0.119020513989547 0.41045993473152 GO:0003712 transcription coregulator activity 16/436 495/18639 0.0323232323232323 1.38181818181818 0.12113691570732 0.415000389878206 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/436 52/18639 0.0576923076923077 2.46634615384615 0.121777840872728 0.415000389878206 GO:0015216 purine nucleotide transmembrane transporter activity 2/436 26/18639 0.0769230769230769 3.28846153846154 0.122938986970189 0.415000389878206 GO:0097602 cullin family protein binding 2/436 26/18639 0.0769230769230769 3.28846153846154 0.122938986970189 0.415000389878206 GO:0004364 glutathione transferase activity 2/436 27/18639 0.0740740740740741 3.16666666666667 0.130811881803727 0.432424769900403 GO:0008266 poly(U) RNA binding 2/436 27/18639 0.0740740740740741 3.16666666666667 0.130811881803727 0.432424769900403 GO:0008395 steroid hydroxylase activity 2/436 27/18639 0.0740740740740741 3.16666666666667 0.130811881803727 0.432424769900403 GO:0023026 MHC class II protein complex binding 2/436 27/18639 0.0740740740740741 3.16666666666667 0.130811881803727 0.432424769900403 GO:0015485 cholesterol binding 3/436 54/18639 0.0555555555555556 2.375 0.132247204390785 0.434140171749542 GO:0001221 transcription coregulator binding 5/436 115/18639 0.0434782608695652 1.85869565217391 0.132691745283951 0.434140171749542 GO:0004860 protein kinase inhibitor activity 4/436 84/18639 0.0476190476190476 2.03571428571429 0.133985584328578 0.436136748987922 GO:0016866 intramolecular transferase activity 2/436 28/18639 0.0714285714285714 3.05357142857143 0.138796936982497 0.442762228974166 GO:0019789 SUMO transferase activity 2/436 28/18639 0.0714285714285714 3.05357142857143 0.138796936982497 0.442762228974166 GO:0046625 sphingolipid binding 2/436 28/18639 0.0714285714285714 3.05357142857143 0.138796936982497 0.442762228974166 GO:0051537 2 iron, 2 sulfur cluster binding 2/436 28/18639 0.0714285714285714 3.05357142857143 0.138796936982497 0.442762228974166 GO:0003785 actin monomer binding 2/436 29/18639 0.0689655172413793 2.94827586206897 0.146884630528063 0.466230817298031 GO:0003697 single-stranded DNA binding 5/436 121/18639 0.0413223140495868 1.76652892561983 0.154273317501493 0.482595096998381 GO:0008187 poly-pyrimidine tract binding 2/436 30/18639 0.0666666666666667 2.85 0.155065822703241 0.482595096998381 GO:0015215 nucleotide transmembrane transporter activity 2/436 30/18639 0.0666666666666667 2.85 0.155065822703241 0.482595096998381 GO:0031210 phosphatidylcholine binding 2/436 30/18639 0.0666666666666667 2.85 0.155065822703241 0.482595096998381 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 5/436 122/18639 0.040983606557377 1.75204918032787 0.158004921174844 0.489355047133739 GO:0019210 kinase inhibitor activity 4/436 90/18639 0.0444444444444444 1.9 0.159902754963977 0.492840375202982 GO:0003730 mRNA 3'-UTR binding 9/436 262/18639 0.0343511450381679 1.46851145038168 0.162481563548771 0.498380949731325 GO:0008327 methyl-CpG binding 2/436 31/18639 0.0645161290322581 2.75806451612903 0.163331743408121 0.498591637772159 GO:0016836 hydro-lyase activity 3/436 61/18639 0.0491803278688525 2.10245901639344 0.17111719225129 0.516500484985502 GO:0051059 NF-kappaB binding 2/436 32/18639 0.0625 2.671875 0.171673979954418 0.516500484985502 GO:0140142 nucleocytoplasmic carrier activity 2/436 32/18639 0.0625 2.671875 0.171673979954418 0.516500484985502 GO:0000287 magnesium ion binding 8/436 230/18639 0.0347826086956522 1.48695652173913 0.172436682291398 0.516500484985502 GO:0030296 protein tyrosine kinase activator activity 2/436 33/18639 0.0606060606060606 2.59090909090909 0.180084465207432 0.536887330852062 GO:0005507 copper ion binding 3/436 63/18639 0.0476190476190476 2.03571428571429 0.18276991651058 0.537390823752409 GO:0004867 serine-type endopeptidase inhibitor activity 4/436 95/18639 0.0421052631578947 1.8 0.18278026450513 0.537390823752409 GO:0008276 protein methyltransferase activity 4/436 95/18639 0.0421052631578947 1.8 0.18278026450513 0.537390823752409 GO:0005154 epidermal growth factor receptor binding 2/436 35/18639 0.0571428571428571 2.44285714285714 0.197079572404347 0.560234625959317 GO:0051020 GTPase binding 10/436 315/18639 0.0317460317460317 1.35714285714286 0.204987595173148 0.560234625959317 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/436 36/18639 0.0555555555555556 2.375 0.205649686063797 0.560234625959317 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/436 36/18639 0.0555555555555556 2.375 0.205649686063797 0.560234625959317 GO:0043130 ubiquitin binding 4/436 100/18639 0.04 1.71 0.20665407384504 0.560234625959317 GO:0050840 extracellular matrix binding 3/436 67/18639 0.0447761194029851 1.91417910447761 0.206666617994129 0.560234625959317 GO:0004090 carbonyl reductase (NADPH) activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0004955 prostaglandin receptor activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0005345 purine nucleobase transmembrane transporter activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0005522 profilin binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0016868 intramolecular phosphotransferase activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0032052 bile acid binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0032356 oxidized DNA binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0042975 peroxisome proliferator activated receptor binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0050815 phosphoserine residue binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0098505 G-rich strand telomeric DNA binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:1905394 retromer complex binding 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:1990757 ubiquitin ligase activator activity 1/436 10/18639 0.1 4.275 0.210815612814436 0.560234625959317 GO:0032934 sterol binding 3/436 68/18639 0.0441176470588235 1.88602941176471 0.212748919509222 0.560234625959317 GO:0019838 growth factor binding 5/436 136/18639 0.0367647058823529 1.57169117647059 0.213774101460245 0.560234625959317 GO:0022829 wide pore channel activity 2/436 37/18639 0.0540540540540541 2.31081081081081 0.214259010554974 0.560234625959317 GO:0023023 MHC protein complex binding 2/436 37/18639 0.0540540540540541 2.31081081081081 0.214259010554974 0.560234625959317 GO:0042805 actinin binding 2/436 37/18639 0.0540540540540541 2.31081081081081 0.214259010554974 0.560234625959317 GO:0043394 proteoglycan binding 2/436 37/18639 0.0540540540540541 2.31081081081081 0.214259010554974 0.560234625959317 GO:0140767 enzyme-substrate adaptor activity 5/436 139/18639 0.0359712230215827 1.53776978417266 0.2264674413898 0.573664519946084 GO:0004954 prostanoid receptor activity 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0005114 type II transforming growth factor beta receptor binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0008432 JUN kinase binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0015205 nucleobase transmembrane transporter activity 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0032794 GTPase activating protein binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0034713 type I transforming growth factor beta receptor binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0050998 nitric-oxide synthase binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0070697 activin receptor binding 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/436 11/18639 0.0909090909090909 3.88636363636364 0.229285975840519 0.573664519946084 GO:0042379 chemokine receptor binding 3/436 72/18639 0.0416666666666667 1.78125 0.23743557716338 0.575500228767021 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/436 40/18639 0.05 2.1375 0.240258596384717 0.575500228767021 GO:0050997 quaternary ammonium group binding 2/436 40/18639 0.05 2.1375 0.240258596384717 0.575500228767021 GO:0071855 neuropeptide receptor binding 2/436 40/18639 0.05 2.1375 0.240258596384717 0.575500228767021 GO:0019888 protein phosphatase regulator activity 4/436 107/18639 0.0373831775700935 1.5981308411215 0.241447383822565 0.575500228767021 GO:0003720 telomerase activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0004032 aldose reductase (NADPH) activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0004300 enoyl-CoA hydratase activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0005049 nuclear export signal receptor activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0008179 adenylate cyclase binding 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0008603 cAMP-dependent protein kinase regulator activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0015368 calcium:monoatomic cation antiporter activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0016208 AMP binding 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0016273 arginine N-methyltransferase activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0016274 protein-arginine N-methyltransferase activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0043047 single-stranded telomeric DNA binding 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:1990459 transferrin receptor binding 1/436 12/18639 0.0833333333333333 3.5625 0.247325019996281 0.575500228767021 GO:0019903 protein phosphatase binding 5/436 144/18639 0.0347222222222222 1.484375 0.248092841311191 0.575500228767021 GO:0017080 sodium channel regulator activity 2/436 41/18639 0.0487804878048781 2.08536585365854 0.248962481410185 0.575500228767021 GO:0042287 MHC protein binding 2/436 41/18639 0.0487804878048781 2.08536585365854 0.248962481410185 0.575500228767021 GO:0140297 DNA-binding transcription factor binding 14/436 488/18639 0.0286885245901639 1.22643442622951 0.254504768864949 0.585043214728982 GO:0031492 nucleosomal DNA binding 2/436 42/18639 0.0476190476190476 2.03571428571429 0.257675773258376 0.585043214728982 GO:0035198 miRNA binding 2/436 42/18639 0.0476190476190476 2.03571428571429 0.257675773258376 0.585043214728982 GO:0048487 beta-tubulin binding 2/436 42/18639 0.0476190476190476 2.03571428571429 0.257675773258376 0.585043214728982 GO:0051879 Hsp90 protein binding 2/436 42/18639 0.0476190476190476 2.03571428571429 0.257675773258376 0.585043214728982 GO:0001664 G protein-coupled receptor binding 9/436 297/18639 0.0303030303030303 1.29545454545455 0.261311710747437 0.586921885704295 GO:1902936 phosphatidylinositol bisphosphate binding 4/436 111/18639 0.036036036036036 1.54054054054054 0.261897929813152 0.586921885704295 GO:0003964 RNA-directed DNA polymerase activity 1/436 13/18639 0.0769230769230769 3.28846153846154 0.264942794800685 0.586921885704295 GO:0005542 folic acid binding 1/436 13/18639 0.0769230769230769 3.28846153846154 0.264942794800685 0.586921885704295 GO:0030955 potassium ion binding 1/436 13/18639 0.0769230769230769 3.28846153846154 0.264942794800685 0.586921885704295 GO:0035325 Toll-like receptor binding 1/436 13/18639 0.0769230769230769 3.28846153846154 0.264942794800685 0.586921885704295 GO:0043560 insulin receptor substrate binding 1/436 13/18639 0.0769230769230769 3.28846153846154 0.264942794800685 0.586921885704295 GO:0001046 core promoter sequence-specific DNA binding 2/436 44/18639 0.0454545454545455 1.94318181818182 0.275110053872243 0.607336381904812 GO:0033293 monocarboxylic acid binding 3/436 79/18639 0.0379746835443038 1.62341772151899 0.281648822880283 0.609252577422708 GO:0008392 arachidonate epoxygenase activity 1/436 14/18639 0.0714285714285714 3.05357142857143 0.282149116150782 0.609252577422708 GO:0016530 metallochaperone activity 1/436 14/18639 0.0714285714285714 3.05357142857143 0.282149116150782 0.609252577422708 GO:0042043 neurexin family protein binding 1/436 14/18639 0.0714285714285714 3.05357142857143 0.282149116150782 0.609252577422708 GO:0098847 sequence-specific single stranded DNA binding 1/436 14/18639 0.0714285714285714 3.05357142857143 0.282149116150782 0.609252577422708 GO:1901612 cardiolipin binding 1/436 14/18639 0.0714285714285714 3.05357142857143 0.282149116150782 0.609252577422708 GO:0101005 deubiquitinase activity 4/436 115/18639 0.0347826086956522 1.48695652173913 0.282662637801131 0.609252577422708 GO:0000049 tRNA binding 3/436 80/18639 0.0375 1.603125 0.288034152637773 0.613287391544793 GO:0003774 cytoskeletal motor activity 5/436 153/18639 0.0326797385620915 1.39705882352941 0.288219742569695 0.613287391544793 GO:0015631 tubulin binding 11/436 385/18639 0.0285714285714286 1.22142857142857 0.292013098331222 0.613287391544793 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/436 46/18639 0.0434782608695652 1.85869565217391 0.292522708104939 0.613287391544793 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/436 46/18639 0.0434782608695652 1.85869565217391 0.292522708104939 0.613287391544793 GO:0030276 clathrin binding 2/436 46/18639 0.0434782608695652 1.85869565217391 0.292522708104939 0.613287391544793 GO:0030291 protein serine/threonine kinase inhibitor activity 2/436 46/18639 0.0434782608695652 1.85869565217391 0.292522708104939 0.613287391544793 GO:0019208 phosphatase regulator activity 4/436 117/18639 0.0341880341880342 1.46153846153846 0.293138662448044 0.613287391544793 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0004953 icosanoid receptor activity 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0005523 tropomyosin binding 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0031005 filamin binding 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0033130 acetylcholine receptor binding 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0051371 muscle alpha-actinin binding 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0061578 K63-linked deubiquitinase activity 1/436 15/18639 0.0666666666666667 2.85 0.298953571740487 0.613287391544793 GO:0005504 fatty acid binding 2/436 47/18639 0.0425531914893617 1.81914893617021 0.301209793967762 0.615935412023822 GO:0005125 cytokine activity 7/436 234/18639 0.0299145299145299 1.27884615384615 0.308290780528511 0.627387101036313 GO:0032182 ubiquitin-like protein binding 4/436 120/18639 0.0333333333333333 1.425 0.308943406809396 0.627387101036313 GO:0051117 ATPase binding 3/436 84/18639 0.0357142857142857 1.52678571428571 0.313664812625577 0.627387101036313 GO:0008391 arachidonate monooxygenase activity 1/436 16/18639 0.0625 2.671875 0.31536552635395 0.627387101036313 GO:0016722 oxidoreductase activity, acting on metal ions 1/436 16/18639 0.0625 2.671875 0.31536552635395 0.627387101036313 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/436 16/18639 0.0625 2.671875 0.31536552635395 0.627387101036313 GO:0034450 ubiquitin-ubiquitin ligase activity 1/436 16/18639 0.0625 2.671875 0.31536552635395 0.627387101036313 GO:0005126 cytokine receptor binding 8/436 275/18639 0.0290909090909091 1.24363636363636 0.315795003303775 0.627387101036313 GO:0001222 transcription corepressor binding 2/436 49/18639 0.0408163265306122 1.74489795918367 0.318525043561061 0.627387101036313 GO:0016763 pentosyltransferase activity 2/436 49/18639 0.0408163265306122 1.74489795918367 0.318525043561061 0.627387101036313 GO:0035254 glutamate receptor binding 2/436 49/18639 0.0408163265306122 1.74489795918367 0.318525043561061 0.627387101036313 GO:0008017 microtubule binding 8/436 276/18639 0.0289855072463768 1.23913043478261 0.319260801039088 0.627387101036313 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/436 86/18639 0.0348837209302326 1.49127906976744 0.326506531606144 0.627387101036313 GO:0015605 organophosphate ester transmembrane transporter activity 2/436 50/18639 0.04 1.71 0.327145621655018 0.627387101036313 GO:0008083 growth factor activity 5/436 162/18639 0.0308641975308642 1.31944444444444 0.329412429092744 0.627387101036313 GO:0004550 nucleoside diphosphate kinase activity 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0005092 GDP-dissociation inhibitor activity 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0016018 cyclosporin A binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0030548 acetylcholine receptor regulator activity 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0031489 myosin V binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0036041 long-chain fatty acid binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0046965 nuclear retinoid X receptor binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0048038 quinone binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0070403 NAD+ binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0070492 oligosaccharide binding 1/436 17/18639 0.0588235294117647 2.51470588235294 0.331394127036422 0.627387101036313 GO:0003714 transcription corepressor activity 6/436 204/18639 0.0294117647058824 1.25735294117647 0.34336229066455 0.638088820163661 GO:0005080 protein kinase C binding 2/436 52/18639 0.0384615384615385 1.64423076923077 0.34429511322643 0.638088820163661 GO:0019783 ubiquitin-like protein peptidase activity 4/436 127/18639 0.031496062992126 1.34645669291339 0.346087253525841 0.638088820163661 GO:0017128 phospholipid scramblase activity 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:0070064 proline-rich region binding 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:0070628 proteasome binding 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:0099602 neurotransmitter receptor regulator activity 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:1901611 phosphatidylglycerol binding 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:1990381 ubiquitin-specific protease binding 1/436 18/18639 0.0555555555555556 2.375 0.34704830814544 0.638088820163661 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/436 128/18639 0.03125 1.3359375 0.351408114244138 0.641303654493671 GO:0004864 protein phosphatase inhibitor activity 2/436 53/18639 0.0377358490566038 1.61320754716981 0.352817527785703 0.641303654493671 GO:0140296 general transcription initiation factor binding 2/436 53/18639 0.0377358490566038 1.61320754716981 0.352817527785703 0.641303654493671 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/436 53/18639 0.0377358490566038 1.61320754716981 0.352817527785703 0.641303654493671 GO:0005516 calmodulin binding 6/436 207/18639 0.0289855072463768 1.23913043478261 0.355838386866678 0.644957076195855 GO:0051287 NAD binding 2/436 54/18639 0.037037037037037 1.58333333333333 0.36130100176243 0.650439299005368 GO:0031420 alkali metal ion binding 1/436 19/18639 0.0526315789473684 2.25 0.362336796285099 0.650439299005368 GO:0070003 threonine-type peptidase activity 1/436 19/18639 0.0526315789473684 2.25 0.362336796285099 0.650439299005368 GO:0046982 protein heterodimerization activity 10/436 369/18639 0.02710027100271 1.15853658536585 0.363069866662801 0.650439299005368 GO:0043178 alcohol binding 3/436 92/18639 0.0326086956521739 1.39402173913043 0.364963764670317 0.650439299005368 GO:0140104 molecular carrier activity 7/436 249/18639 0.0281124497991968 1.20180722891566 0.364980045523388 0.650439299005368 GO:0008374 O-acyltransferase activity 2/436 55/18639 0.0363636363636364 1.55454545454545 0.369742695918487 0.657091476311962 GO:0005179 hormone activity 4/436 132/18639 0.0303030303030303 1.29545454545455 0.372687117907954 0.660484392292429 GO:0030627 pre-mRNA 5'-splice site binding 1/436 20/18639 0.05 2.1375 0.377268115126113 0.660967868046691 GO:0030742 GTP-dependent protein binding 1/436 20/18639 0.05 2.1375 0.377268115126113 0.660967868046691 GO:0061608 nuclear import signal receptor activity 1/436 20/18639 0.05 2.1375 0.377268115126113 0.660967868046691 GO:0140939 histone H4 methyltransferase activity 1/436 20/18639 0.05 2.1375 0.377268115126113 0.660967868046691 GO:0019212 phosphatase inhibitor activity 2/436 56/18639 0.0357142857142857 1.52678571428571 0.378139924509471 0.660967868046691 GO:0005543 phospholipid binding 13/436 497/18639 0.0261569416498994 1.1182092555332 0.38017386979428 0.662707456089483 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/436 57/18639 0.0350877192982456 1.5 0.386490149686026 0.668451006665568 GO:0016741 transferase activity, transferring one-carbon groups 6/436 215/18639 0.027906976744186 1.19302325581395 0.389226909167259 0.668451006665568 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:0010314 phosphatidylinositol-5-phosphate binding 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:0051428 peptide hormone receptor binding 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:0061891 calcium ion sensor activity 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:1904047 S-adenosyl-L-methionine binding 1/436 21/18639 0.0476190476190476 2.03571428571429 0.391850590114298 0.668451006665568 GO:0061980 regulatory RNA binding 2/436 58/18639 0.0344827586206897 1.47413793103448 0.394790976072097 0.671671047290661 GO:0015459 potassium channel regulator activity 2/436 59/18639 0.0338983050847458 1.44915254237288 0.403040145514969 0.680018166033311 GO:0036002 pre-mRNA binding 2/436 59/18639 0.0338983050847458 1.44915254237288 0.403040145514969 0.680018166033311 GO:0045309 protein phosphorylated amino acid binding 2/436 59/18639 0.0338983050847458 1.44915254237288 0.403040145514969 0.680018166033311 GO:0008093 cytoskeletal anchor activity 1/436 22/18639 0.0454545454545455 1.94318181818182 0.406092353070049 0.680018166033311 GO:0008649 rRNA methyltransferase activity 1/436 22/18639 0.0454545454545455 1.94318181818182 0.406092353070049 0.680018166033311 GO:0140784 metal ion sensor activity 1/436 22/18639 0.0454545454545455 1.94318181818182 0.406092353070049 0.680018166033311 GO:0001098 basal transcription machinery binding 2/436 60/18639 0.0333333333333333 1.425 0.411235532002025 0.683250701607532 GO:0001099 basal RNA polymerase II transcription machinery binding 2/436 60/18639 0.0333333333333333 1.425 0.411235532002025 0.683250701607532 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/436 60/18639 0.0333333333333333 1.425 0.411235532002025 0.683250701607532 GO:0005158 insulin receptor binding 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:0031681 G-protein beta-subunit binding 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:0043274 phospholipase binding 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:0099186 structural constituent of postsynapse 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:0140102 catalytic activity, acting on a rRNA 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/436 23/18639 0.0434782608695652 1.85869565217391 0.420001346681343 0.687079126109479 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 9/436 349/18639 0.0257879656160458 1.10243553008596 0.430745607008058 0.699667852635025 GO:0015149 hexose transmembrane transporter activity 1/436 24/18639 0.0416666666666667 1.78125 0.433585328892717 0.699667852635025 GO:0035035 histone acetyltransferase binding 1/436 24/18639 0.0416666666666667 1.78125 0.433585328892717 0.699667852635025 GO:0055056 D-glucose transmembrane transporter activity 1/436 24/18639 0.0416666666666667 1.78125 0.433585328892717 0.699667852635025 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/436 24/18639 0.0416666666666667 1.78125 0.433585328892717 0.699667852635025 GO:0005253 monoatomic anion channel activity 3/436 103/18639 0.029126213592233 1.24514563106796 0.434276598187257 0.699667852635025 GO:0004536 DNA nuclease activity 2/436 64/18639 0.03125 1.3359375 0.443441081805281 0.708593610162731 GO:0031406 carboxylic acid binding 5/436 187/18639 0.0267379679144385 1.14304812834225 0.445068331842362 0.708593610162731 GO:0017056 structural constituent of nuclear pore 1/436 25/18639 0.04 1.71 0.446851877192624 0.708593610162731 GO:0042974 nuclear retinoic acid receptor binding 1/436 25/18639 0.04 1.71 0.446851877192624 0.708593610162731 GO:0004497 monooxygenase activity 3/436 106/18639 0.0283018867924528 1.20990566037736 0.45272446601936 0.708593610162731 GO:0043177 organic acid binding 5/436 189/18639 0.0264550264550265 1.13095238095238 0.45419170356646 0.708593610162731 GO:0019902 phosphatase binding 5/436 190/18639 0.0263157894736842 1.125 0.458738305902942 0.708593610162731 GO:0004435 phosphatidylinositol phospholipase C activity 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0005160 transforming growth factor beta receptor binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0008157 protein phosphatase 1 binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0008198 ferrous iron binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0015145 monosaccharide transmembrane transporter activity 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0019865 immunoglobulin binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0050681 nuclear androgen receptor binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0050750 low-density lipoprotein particle receptor binding 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0051139 metal cation:proton antiporter activity 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0120014 phospholipid transfer activity 1/436 26/18639 0.0384615384615385 1.64423076923077 0.459808392801521 0.708593610162731 GO:0005496 steroid binding 3/436 108/18639 0.0277777777777778 1.1875 0.464884503744515 0.714689911780725 GO:0042054 histone methyltransferase activity 2/436 67/18639 0.0298507462686567 1.27611940298507 0.466944276377301 0.715987702704936 GO:0001671 ATPase activator activity 1/436 27/18639 0.037037037037037 1.58333333333333 0.472462104762975 0.715987702704936 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/436 27/18639 0.037037037037037 1.58333333333333 0.472462104762975 0.715987702704936 GO:0008320 protein transmembrane transporter activity 1/436 27/18639 0.037037037037037 1.58333333333333 0.472462104762975 0.715987702704936 GO:0015252 proton channel activity 1/436 27/18639 0.037037037037037 1.58333333333333 0.472462104762975 0.715987702704936 GO:0035255 ionotropic glutamate receptor binding 1/436 27/18639 0.037037037037037 1.58333333333333 0.472462104762975 0.715987702704936 GO:0005548 phospholipid transporter activity 2/436 68/18639 0.0294117647058824 1.25735294117647 0.474647165979365 0.71759453055648 GO:0046875 ephrin receptor binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0051019 mitogen-activated protein kinase binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0051119 sugar transmembrane transporter activity 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0051393 alpha-actinin binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0051959 dynein light intermediate chain binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0097718 disordered domain specific binding 1/436 28/18639 0.0357142857142857 1.52678571428571 0.48482007394003 0.721014468936455 GO:0004629 phospholipase C activity 1/436 29/18639 0.0344827586206897 1.47413793103448 0.496889196919029 0.732809038259109 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/436 29/18639 0.0344827586206897 1.47413793103448 0.496889196919029 0.732809038259109 GO:0097472 cyclin-dependent protein kinase activity 1/436 29/18639 0.0344827586206897 1.47413793103448 0.496889196919029 0.732809038259109 GO:0140299 molecular sensor activity 2/436 71/18639 0.028169014084507 1.20422535211268 0.49734531906927 0.732809038259109 GO:0017124 SH3 domain binding 3/436 115/18639 0.0260869565217391 1.11521739130435 0.506456219739503 0.735907986093169 GO:0001965 G-protein alpha-subunit binding 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0001968 fibronectin binding 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0016769 transferase activity, transferring nitrogenous groups 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0033612 receptor serine/threonine kinase binding 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0048019 receptor antagonist activity 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0098918 structural constituent of synapse 1/436 30/18639 0.0333333333333333 1.425 0.508676209823022 0.735907986093169 GO:0003684 damaged DNA binding 2/436 74/18639 0.027027027027027 1.15540540540541 0.519408266207334 0.740384360440116 GO:0031491 nucleosome binding 2/436 74/18639 0.027027027027027 1.15540540540541 0.519408266207334 0.740384360440116 GO:0005184 neuropeptide hormone activity 1/436 31/18639 0.032258064516129 1.37903225806452 0.520187692036851 0.740384360440116 GO:0047499 calcium-independent phospholipase A2 activity 1/436 31/18639 0.032258064516129 1.37903225806452 0.520187692036851 0.740384360440116 GO:0070273 phosphatidylinositol-4-phosphate binding 1/436 31/18639 0.032258064516129 1.37903225806452 0.520187692036851 0.740384360440116 GO:0070325 lipoprotein particle receptor binding 1/436 31/18639 0.032258064516129 1.37903225806452 0.520187692036851 0.740384360440116 GO:0033218 amide binding 6/436 247/18639 0.0242914979757085 1.03846153846154 0.520376114175085 0.740384360440116 GO:0008168 methyltransferase activity 5/436 204/18639 0.0245098039215686 1.04779411764706 0.521054197237636 0.740384360440116 GO:0019003 GDP binding 2/436 75/18639 0.0266666666666667 1.14 0.52661784640843 0.746627080019063 GO:0022884 macromolecule transmembrane transporter activity 1/436 32/18639 0.03125 1.3359375 0.531430069845962 0.74846001007003 GO:0047498 calcium-dependent phospholipase A2 activity 1/436 32/18639 0.03125 1.3359375 0.531430069845962 0.74846001007003 GO:0160041 neuropeptide activity 1/436 32/18639 0.03125 1.3359375 0.531430069845962 0.74846001007003 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/436 33/18639 0.0303030303030303 1.29545454545455 0.542409619990916 0.75889767007501 GO:0019956 chemokine binding 1/436 33/18639 0.0303030303030303 1.29545454545455 0.542409619990916 0.75889767007501 GO:0071889 14-3-3 protein binding 1/436 33/18639 0.0303030303030303 1.29545454545455 0.542409619990916 0.75889767007501 GO:0030332 cyclin binding 1/436 34/18639 0.0294117647058824 1.25735294117647 0.553132473139576 0.770700044096472 GO:0004623 phospholipase A2 activity 1/436 35/18639 0.0285714285714286 1.22142857142857 0.563604617278847 0.770700044096472 GO:0034061 DNA polymerase activity 1/436 35/18639 0.0285714285714286 1.22142857142857 0.563604617278847 0.770700044096472 GO:0019787 ubiquitin-like protein transferase activity 11/436 479/18639 0.022964509394572 0.981732776617954 0.567800821264483 0.770700044096472 GO:0001618 virus receptor activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0033192 calmodulin-dependent protein phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0140791 histone H2AXS140 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/436 81/18639 0.0246913580246914 1.05555555555556 0.568317988515054 0.770700044096472 GO:0042826 histone deacetylase binding 3/436 127/18639 0.0236220472440945 1.00984251968504 0.573569409685476 0.770700044096472 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/436 36/18639 0.0277777777777778 1.1875 0.573831901027849 0.770700044096472 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/436 36/18639 0.0277777777777778 1.1875 0.573831901027849 0.770700044096472 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/436 36/18639 0.0277777777777778 1.1875 0.573831901027849 0.770700044096472 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/436 82/18639 0.024390243902439 1.04268292682927 0.575005048573543 0.770700044096472 GO:0033549 MAP kinase phosphatase activity 2/436 82/18639 0.024390243902439 1.04268292682927 0.575005048573543 0.770700044096472 GO:0140272 exogenous protein binding 2/436 82/18639 0.024390243902439 1.04268292682927 0.575005048573543 0.770700044096472 GO:0031490 chromatin DNA binding 3/436 128/18639 0.0234375 1.001953125 0.578901280776067 0.774295633406983 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/436 83/18639 0.0240963855421687 1.03012048192771 0.581616341196859 0.776299635321331 GO:0030280 structural constituent of skin epidermis 1/436 37/18639 0.027027027027027 1.15540540540541 0.583820036874317 0.777614161849299 GO:0017018 myosin phosphatase activity 2/436 84/18639 0.0238095238095238 1.01785714285714 0.588151744332744 0.781751693508939 GO:0000146 microfilament motor activity 1/436 38/18639 0.0263157894736842 1.125 0.593574604336031 0.784059208211983 GO:0005109 frizzled binding 1/436 38/18639 0.0263157894736842 1.125 0.593574604336031 0.784059208211983 GO:0043531 ADP binding 1/436 38/18639 0.0263157894736842 1.125 0.593574604336031 0.784059208211983 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/436 39/18639 0.0256410256410256 1.09615384615385 0.603101053048976 0.794996842655469 GO:0015144 carbohydrate transmembrane transporter activity 1/436 40/18639 0.025 1.06875 0.612404705783957 0.803938687839845 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/436 40/18639 0.025 1.06875 0.612404705783957 0.803938687839845 GO:0016755 aminoacyltransferase activity 11/436 496/18639 0.0221774193548387 0.948084677419355 0.614270900089829 0.804076266727004 GO:0015297 antiporter activity 3/436 135/18639 0.0222222222222222 0.95 0.615030122512191 0.804076266727004 GO:0140318 protein transporter activity 1/436 41/18639 0.024390243902439 1.04268292682927 0.621490761393301 0.809206338303931 GO:0140828 metal cation:monoatomic cation antiporter activity 1/436 41/18639 0.024390243902439 1.04268292682927 0.621490761393301 0.809206338303931 GO:1901681 sulfur compound binding 6/436 275/18639 0.0218181818181818 0.932727272727273 0.625178241627439 0.812349731483312 GO:0004520 DNA endonuclease activity 1/436 42/18639 0.0238095238095238 1.01785714285714 0.630364297689275 0.814114214424611 GO:0016859 cis-trans isomerase activity 1/436 42/18639 0.0238095238095238 1.01785714285714 0.630364297689275 0.814114214424611 GO:0019894 kinesin binding 1/436 42/18639 0.0238095238095238 1.01785714285714 0.630364297689275 0.814114214424611 GO:1901981 phosphatidylinositol phosphate binding 4/436 185/18639 0.0216216216216216 0.924324324324324 0.631743448115255 0.814247110904106 GO:0070851 growth factor receptor binding 3/436 139/18639 0.0215827338129496 0.922661870503597 0.634715852983329 0.816428859280975 GO:0048156 tau protein binding 1/436 43/18639 0.0232558139534884 0.994186046511628 0.63903027425579 0.820324577414877 GO:0051219 phosphoprotein binding 2/436 93/18639 0.021505376344086 0.919354838709677 0.643556880052991 0.824476484887166 GO:0001223 transcription coactivator binding 1/436 44/18639 0.0227272727272727 0.971590909090909 0.647493535194942 0.827857465840427 GO:0042562 hormone binding 2/436 94/18639 0.0212765957446809 0.909574468085106 0.649336030769454 0.828552775261824 GO:0031267 small GTPase binding 6/436 283/18639 0.0212014134275618 0.906360424028269 0.652599186878635 0.831054453550039 GO:0051539 4 iron, 4 sulfur cluster binding 1/436 45/18639 0.0222222222222222 0.95 0.655758811809893 0.831757697683323 GO:0140303 intramembrane lipid transporter activity 1/436 45/18639 0.0222222222222222 0.95 0.655758811809893 0.831757697683323 GO:0008170 N-methyltransferase activity 2/436 98/18639 0.0204081632653061 0.872448979591837 0.671710339296139 0.845272973075301 GO:0001784 phosphotyrosine residue binding 1/436 47/18639 0.0212765957446809 0.909574468085106 0.671713788948554 0.845272973075301 GO:0043495 protein-membrane adaptor activity 1/436 47/18639 0.0212765957446809 0.909574468085106 0.671713788948554 0.845272973075301 GO:0140938 histone H3 methyltransferase activity 1/436 47/18639 0.0212765957446809 0.909574468085106 0.671713788948554 0.845272973075301 GO:0032266 phosphatidylinositol-3-phosphate binding 1/436 48/18639 0.0208333333333333 0.890625 0.67941241136779 0.85160141149833 GO:0140693 molecular condensate scaffold activity 1/436 48/18639 0.0208333333333333 0.890625 0.67941241136779 0.85160141149833 GO:0008509 monoatomic anion transmembrane transporter activity 3/436 149/18639 0.0201342281879195 0.860738255033557 0.680813573210535 0.85168443080063 GO:0048020 CCR chemokine receptor binding 1/436 50/18639 0.02 0.855 0.694273454861221 0.866822826225947 GO:0004722 protein serine/threonine phosphatase activity 2/436 103/18639 0.0194174757281553 0.830097087378641 0.698036395442704 0.869818789633682 GO:0016830 carbon-carbon lyase activity 1/436 51/18639 0.0196078431372549 0.838235294117647 0.701444188826496 0.872361388832952 GO:0017046 peptide hormone binding 1/436 53/18639 0.0188679245283019 0.806603773584906 0.715286142340781 0.886121473424113 GO:0051018 protein kinase A binding 1/436 53/18639 0.0188679245283019 0.806603773584906 0.715286142340781 0.886121473424113 GO:0050661 NADP binding 1/436 54/18639 0.0185185185185185 0.791666666666667 0.721965107257354 0.891708372995111 GO:0004843 cysteine-type deubiquitinase activity 2/436 108/18639 0.0185185185185185 0.791666666666667 0.7225912677719 0.891708372995111 GO:0004620 phospholipase activity 2/436 109/18639 0.018348623853211 0.784403669724771 0.727295402655355 0.895780824119916 GO:0005178 integrin binding 3/436 161/18639 0.0186335403726708 0.796583850931677 0.73025688044921 0.89769535592793 GO:0030170 pyridoxal phosphate binding 1/436 56/18639 0.0178571428571429 0.763392857142857 0.734857704867914 0.901613876357171 GO:0070279 vitamin B6 binding 1/436 57/18639 0.0175438596491228 0.75 0.74107855406759 0.907501185211367 GO:0008408 3'-5' exonuclease activity 1/436 58/18639 0.0172413793103448 0.737068965517241 0.747153774734178 0.913187946897328 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/436 167/18639 0.0179640718562874 0.767964071856287 0.752628423915829 0.916926256110337 GO:0031593 polyubiquitin modification-dependent protein binding 1/436 59/18639 0.0169491525423729 0.724576271186441 0.753086768341406 0.916926256110337 GO:0019905 syntaxin binding 1/436 61/18639 0.0163934426229508 0.700819672131148 0.76453928576548 0.929097265368336 GO:0008201 heparin binding 3/436 172/18639 0.0174418604651163 0.745639534883721 0.770113909853011 0.934092537046048 GO:0004721 phosphoprotein phosphatase activity 3/436 175/18639 0.0171428571428571 0.732857142857143 0.780113289442001 0.944425576212518 GO:0120013 lipid transfer activity 1/436 65/18639 0.0153846153846154 0.657692307692308 0.785878684922467 0.949453341673815 GO:0030246 carbohydrate binding 5/436 280/18639 0.0178571428571429 0.763392857142857 0.787242661043022 0.949453341673815 GO:0005085 guanyl-nucleotide exchange factor activity 4/436 230/18639 0.0173913043478261 0.743478260869565 0.789458629738306 0.950329444854791 GO:0008173 RNA methyltransferase activity 1/436 67/18639 0.0149253731343284 0.638059701492537 0.795813392904921 0.954377715551391 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/436 67/18639 0.0149253731343284 0.638059701492537 0.795813392904921 0.954377715551391 GO:0035091 phosphatidylinositol binding 5/436 284/18639 0.0176056338028169 0.752640845070423 0.797344076231034 0.954419363293433 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3/436 181/18639 0.0165745856353591 0.708563535911602 0.799038382119853 0.954656344180648 GO:0003777 microtubule motor activity 1/436 68/18639 0.0147058823529412 0.628676470588235 0.80060691867993 0.954742456294944 GO:0016279 protein-lysine N-methyltransferase activity 1/436 69/18639 0.0144927536231884 0.619565217391304 0.805288162740861 0.958533298187815 GO:0008237 metallopeptidase activity 3/436 184/18639 0.016304347826087 0.697010869565217 0.807979307321262 0.959945620243883 GO:0016278 lysine N-methyltransferase activity 1/436 70/18639 0.0142857142857143 0.610714285714286 0.809859749226859 0.960391301127762 GO:0016298 lipase activity 2/436 130/18639 0.0153846153846154 0.657692307692308 0.811407069016188 0.960441020468141 GO:0008234 cysteine-type peptidase activity 3/436 187/18639 0.0160427807486631 0.685828877005348 0.816583097689148 0.964777808010512 GO:0005518 collagen binding 1/436 72/18639 0.0138888888888889 0.59375 0.818684141500212 0.965472240808014 GO:0005539 glycosaminoglycan binding 4/436 242/18639 0.0165289256198347 0.706611570247934 0.82098428360483 0.966398474058823 GO:0004842 ubiquitin-protein transferase activity 8/436 449/18639 0.0178173719376392 0.761692650334076 0.828146239060272 0.972547194890876 GO:0016779 nucleotidyltransferase activity 2/436 136/18639 0.0147058823529412 0.628676470588235 0.830780910996125 0.972547194890876 GO:0140789 histone phosphatase activity 2/436 136/18639 0.0147058823529412 0.628676470588235 0.830780910996125 0.972547194890876 GO:0042393 histone binding 4/436 247/18639 0.0161943319838057 0.692307692307692 0.832924214822059 0.972547710267974 GO:0016922 nuclear receptor binding 2/436 137/18639 0.0145985401459854 0.624087591240876 0.833830090151382 0.972547710267974 GO:0019955 cytokine binding 2/436 144/18639 0.0138888888888889 0.59375 0.853820703541704 0.994046731495634 GO:0001540 amyloid-beta binding 1/436 83/18639 0.0120481927710843 0.515060240963855 0.86040011266693 0.998064130693638 GO:0005254 chloride channel activity 1/436 83/18639 0.0120481927710843 0.515060240963855 0.86040011266693 0.998064130693638 GO:0004527 exonuclease activity 1/436 84/18639 0.0119047619047619 0.508928571428571 0.863680213490233 0.999992337944505 GO:0019842 vitamin binding 2/436 150/18639 0.0133333333333333 0.57 0.86918510171317 0.999992337944505 GO:0050660 flavin adenine dinucleotide binding 1/436 86/18639 0.0116279069767442 0.497093023255814 0.870011519636472 0.999992337944505 GO:0008081 phosphoric diester hydrolase activity 1/436 87/18639 0.0114942528735632 0.491379310344828 0.873066280453509 0.999992337944505 GO:0004197 cysteine-type endopeptidase activity 1/436 88/18639 0.0113636363636364 0.485795454545455 0.876049414440264 0.999992337944505 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/436 89/18639 0.0112359550561798 0.480337078651685 0.878962597303939 0.999992337944505 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/436 89/18639 0.0112359550561798 0.480337078651685 0.878962597303939 0.999992337944505 GO:0140793 histone H2AXY142 phosphatase activity 1/436 90/18639 0.0111111111111111 0.475 0.881807465636849 0.999992337944505 GO:0004725 protein tyrosine phosphatase activity 1/436 98/18639 0.0102040816326531 0.436224489795918 0.902291274670347 0.999992337944505 GO:0030527 structural constituent of chromatin 1/436 98/18639 0.0102040816326531 0.436224489795918 0.902291274670347 0.999992337944505 GO:0005244 voltage-gated monoatomic ion channel activity 2/436 173/18639 0.0115606936416185 0.494219653179191 0.915302959618933 0.999992337944505 GO:0022832 voltage-gated channel activity 2/436 175/18639 0.0114285714285714 0.488571428571429 0.91849472214529 0.999992337944505 GO:0000149 SNARE binding 1/436 106/18639 0.00943396226415094 0.403301886792453 0.919231772687345 0.999992337944505 GO:0008013 beta-catenin binding 1/436 106/18639 0.00943396226415094 0.403301886792453 0.919231772687345 0.999992337944505 GO:0004252 serine-type endopeptidase activity 2/436 176/18639 0.0113636363636364 0.485795454545455 0.920047926163075 0.999992337944505 GO:0045182 translation regulator activity 5/436 356/18639 0.0140449438202247 0.600421348314607 0.922081690192605 0.999992337944505 GO:0005319 lipid transporter activity 2/436 178/18639 0.0112359550561798 0.480337078651685 0.923071252442937 0.999992337944505 GO:0016887 ATP hydrolysis activity 6/436 417/18639 0.0143884892086331 0.615107913669065 0.927656310995014 0.999992337944505 GO:0042277 peptide binding 3/436 249/18639 0.0120481927710843 0.515060240963855 0.933234022861336 0.999992337944505 GO:0035401 histone H3Y41 kinase activity 1/436 115/18639 0.00869565217391304 0.371739130434783 0.934811953571848 0.999992337944505 GO:0140801 histone H2AXY142 kinase activity 1/436 115/18639 0.00869565217391304 0.371739130434783 0.934811953571848 0.999992337944505 GO:0004674 protein serine/threonine kinase activity 6/436 433/18639 0.0138568129330254 0.592378752886836 0.941833636903783 0.999992337944505 GO:0030695 GTPase regulator activity 7/436 489/18639 0.0143149284253579 0.611963190184049 0.942187247927411 0.999992337944505 GO:0060589 nucleoside-triphosphatase regulator activity 7/436 490/18639 0.0142857142857143 0.610714285714286 0.942940093593098 0.999992337944505 GO:0015108 chloride transmembrane transporter activity 1/436 121/18639 0.00826446280991736 0.353305785123967 0.943494054054108 0.999992337944505 GO:0008236 serine-type peptidase activity 2/436 194/18639 0.0103092783505155 0.440721649484536 0.943657456078645 0.999992337944505 GO:0017171 serine hydrolase activity 2/436 198/18639 0.0101010101010101 0.431818181818182 0.947919259865421 0.999992337944505 GO:0004519 endonuclease activity 1/436 127/18639 0.0078740157480315 0.336614173228346 0.95102212072341 0.999992337944505 GO:0016757 glycosyltransferase activity 3/436 267/18639 0.0112359550561798 0.480337078651685 0.951136669504092 0.999992337944505 GO:0035591 signaling adaptor activity 1/436 129/18639 0.00775193798449612 0.331395348837209 0.953302095506456 0.999992337944505 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/436 130/18639 0.00769230769230769 0.328846153846154 0.954402056952117 0.999992337944505 GO:0005096 GTPase activator activity 3/436 271/18639 0.011070110701107 0.473247232472325 0.95445511414929 0.999992337944505 GO:0005262 calcium channel activity 1/436 131/18639 0.00763358778625954 0.326335877862595 0.955476167015809 0.999992337944505 GO:0016791 phosphatase activity 3/436 273/18639 0.010989010989011 0.46978021978022 0.956034328868005 0.999992337944505 GO:0140097 catalytic activity, acting on DNA 4/436 336/18639 0.0119047619047619 0.508928571428571 0.956531112182134 0.999992337944505 GO:0004518 nuclease activity 2/436 209/18639 0.00956937799043062 0.409090909090909 0.958112839535779 0.999992337944505 GO:0004713 protein tyrosine kinase activity 1/436 140/18639 0.00714285714285714 0.305357142857143 0.964075337046516 0.999992337944505 GO:0015291 secondary active transmembrane transporter activity 3/436 287/18639 0.0104529616724739 0.446864111498258 0.965734450064381 0.999992337944505 GO:0061630 ubiquitin protein ligase activity 4/436 353/18639 0.0113314447592068 0.484419263456091 0.967089535702004 0.999992337944505 GO:0015085 calcium ion transmembrane transporter activity 1/436 147/18639 0.00680272108843537 0.290816326530612 0.969600096427058 0.999992337944505 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/436 229/18639 0.00873362445414847 0.373362445414847 0.971957425459762 0.999992337944505 GO:0042578 phosphoric ester hydrolase activity 4/436 363/18639 0.0110192837465565 0.471074380165289 0.972131705899839 0.999992337944505 GO:0061659 ubiquitin-like protein ligase activity 4/436 372/18639 0.010752688172043 0.459677419354839 0.976043441887014 0.999992337944505 GO:0015103 inorganic anion transmembrane transporter activity 1/436 165/18639 0.00606060606060606 0.259090909090909 0.980218314787064 0.999992337944505 GO:0035402 histone H3T11 kinase activity 2/436 247/18639 0.00809716599190283 0.346153846153846 0.980557765582097 0.999992337944505 GO:0005216 monoatomic ion channel activity 5/436 448/18639 0.0111607142857143 0.477120535714286 0.980737986422491 0.999992337944505 GO:0016874 ligase activity 1/436 167/18639 0.00598802395209581 0.255988023952096 0.981141045835938 0.999992337944505 GO:0005201 extracellular matrix structural constituent 1/436 168/18639 0.00595238095238095 0.254464285714286 0.981586179227857 0.999992337944505 GO:0140030 modification-dependent protein binding 1/436 173/18639 0.00578034682080925 0.247109826589595 0.983659440662633 0.999992337944505 GO:0003823 antigen binding 1/436 174/18639 0.00574712643678161 0.245689655172414 0.98404525696671 0.999992337944505 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 2/436 268/18639 0.00746268656716418 0.319029850746269 0.987387343236982 0.999992337944505 GO:0008514 organic anion transmembrane transporter activity 2/436 269/18639 0.00743494423791822 0.317843866171004 0.987646251540709 0.999992337944505 GO:0001217 DNA-binding transcription repressor activity 2/436 278/18639 0.00719424460431655 0.307553956834532 0.98975519542095 0.999992337944505 GO:0016758 hexosyltransferase activity 1/436 197/18639 0.0050761421319797 0.217005076142132 0.990794247229456 0.999992337944505 GO:0035173 histone kinase activity 3/436 360/18639 0.00833333333333333 0.35625 0.991156952591823 0.999992337944505 GO:0106310 protein serine kinase activity 3/436 361/18639 0.00831024930747922 0.355263157894737 0.991324316184601 0.999992337944505 GO:0022836 gated channel activity 2/436 318/18639 0.00628930817610063 0.268867924528302 0.995587210635877 0.999992337944505 GO:0004175 endopeptidase activity 3/436 405/18639 0.00740740740740741 0.316666666666667 0.996303431608188 0.999992337944505 GO:0030371 translation repressor activity 2/436 329/18639 0.0060790273556231 0.259878419452888 0.99650889521847 0.999992337944505 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1/436 243/18639 0.00411522633744856 0.175925925925926 0.996941611621802 0.999992337944505 GO:0004676 3-phosphoinositide-dependent protein kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0004711 ribosomal protein S6 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0035175 histone H3S10 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0035979 histone H2AXS139 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0044022 histone H3S28 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0044023 histone H4S1 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0044024 histone H2AS1 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0044025 histone H2BS14 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0072354 histone H3T3 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0072371 histone H2AS121 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0072518 Rho-dependent protein serine/threonine kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0140823 histone H2BS36 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0140855 histone H3S57 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0140995 histone H2A kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0140997 histone H4 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0140998 histone H2B kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:1990244 histone H2AT120 kinase activity 1/436 245/18639 0.00408163265306122 0.174489795918367 0.997084870016362 0.999992337944505 GO:0004677 DNA-dependent protein kinase activity 1/436 246/18639 0.0040650406504065 0.173780487804878 0.997153968454596 0.999992337944505 GO:0140857 histone H3T45 kinase activity 1/436 246/18639 0.0040650406504065 0.173780487804878 0.997153968454596 0.999992337944505 GO:0035403 histone H3T6 kinase activity 1/436 247/18639 0.00404858299595142 0.173076923076923 0.997221432693915 0.999992337944505 GO:0004679 AMP-activated protein kinase activity 1/436 248/18639 0.00403225806451613 0.172379032258065 0.997287301296865 0.999992337944505 GO:0005261 monoatomic cation channel activity 2/436 341/18639 0.00586510263929619 0.250733137829912 0.997299478266352 0.999992337944505 GO:0141003 histone H2AX kinase activity 2/436 354/18639 0.00564971751412429 0.241525423728814 0.997957957813321 0.999992337944505 GO:0140996 histone H3 kinase activity 2/436 357/18639 0.00560224089635854 0.239495798319328 0.998085868800995 0.999992337944505 GO:0140098 catalytic activity, acting on RNA 1/436 387/18639 0.00258397932816537 0.11046511627907 0.999904610025196 0.999992337944505 GO:0046873 metal ion transmembrane transporter activity 1/436 450/18639 0.00222222222222222 0.095 0.999979258186455 0.999992337944505 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1/436 484/18639 0.00206611570247934 0.0883264462809917 0.999990916421516 0.999992337944505 GO:0001216 DNA-binding transcription activator activity 1/436 491/18639 0.00203665987780041 0.0870672097759674 0.999992337944505 0.999992337944505