category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	65/1132	248/9376	2.17086515445116	GAPDH/ACTG1/FLNA/DYNLL1/TUBB6/TNFRSF1A/PFN1/ACTB/HSP90AB1/RHOA/TNFSF10/PKN1/IRAK1/RAB7A/BIRC3/ARPC4/TUBA1A/MYL9/AKT1/ANXA2/AHNAK/RALA/CTNNB1/CXCL8/PIK3C2A/M6PR/MAPK1/SNX9/ACTR10/MAP2K3/ARL8B/DCTN6/PTPRC/TUBB4B/LEF1/ARF1/PLEKHM2/RILP/MAPK3/TUBA1C/DYNLRB1/LY96/CDC42/MAP2K2/DNM2/VPS41/PIK3CB/DYNLT3/MYL12B/FADD/TUBA4A/RHOG/MYL12A/RIPK2/ARPC1A/TXN/GSDMD/TNFRSF10B/VPS33A/RAB5C/ARF6/CYCS/RAF1/RAC1/BAK1	6.92444174863629
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	45/1132	170/9376	2.19247557680316	ACTG1/YBX3/EZR/MYH9/ACTB/RAP1A/RHOA/VASP/ACTN1/CLDN7/CTTN/CLDN23/RAB8B/MYL6/ARPC4/RUNX1/TUBA1A/MYL9/LLGL2/CRB3/MPDZ/CLDN3/HSPA4/PRKAG1/PPP2R1B/SYNPO/TUBA1C/CDC42/CLDN15/MYL12B/TUBA4A/PARD6A/AMOTL2/MYL12A/SCRIB/WHAMM/ARPC1A/PRKAA1/PPP2CA/ARHGAP17/PARD6B/RAPGEF6/RAC1/STK11/PPP2R1A	5.81404419178872
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/1132	70/9376	2.72145381120646	RAP1A/TGFB1/EGLN3/CRKL/AKT1/ETS1/NRAS/MAPK1/EGLN2/SLC2A1/RAP1B/MAPK3/PAK4/CDC42/MAP2K2/PIK3CB/EGLN1/VEGFA/PRCC/CRK/RAF1/TFE3/RAC1	5.35676667882891
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	32/1132	116/9376	2.28487876203241	GAPDH/ALDOA/PKM/TPI1/ENO1/SDHA/PGK1/SHMT2/PFKL/PGAM1/ADPGK/SDHC/PFKP/SDHB/HK1/MDH2/IDH3A/ACOX1/SUCLA2/ACOX3/ACAT1/PHGDH/ACO2/SDHD/DLST/SHMT1/TKT/PSPH/DLD/RPE/PDHA1/H6PD	5.15971260280713
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/1132	203/9376	1.91766610384863	FLNB/CAV1/ACTG1/FLNA/LAMC2/CAV2/PGF/ACTB/RAP1A/RHOA/PPP1R12C/VASP/VEGFB/ACTN1/ITGA2/PPP1CC/BIRC3/CRKL/MYL9/AKT1/BCAR1/PXN/CTNNB1/MAPK1/RAP1B/FN1/RAC2/MAPK3/FLT1/COL1A2/PAK4/CDC42/ZYX/DIAPH1/ILK/PIK3CB/MYL12B/VAV2/CAPN2/MYL12A/VEGFA/EMP2/ITGA2B/CRK/RAF1/RAC1/PPP1CB	4.89797847926247
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	28/1132	98/9376	2.36648157496214	MYO10/CFL1/VASP/NCF1/MARCKS/PRKCD/ARPC4/CRKL/LYN/AKT1/MAPK1/ASAP2/PTPRC/RAC2/ASAP1/CFL2/MAPK3/CDC42/DNM2/PIK3CB/FCGR3A/VAV2/ARPC1A/LIMK1/ARF6/CRK/RAF1/RAC1	5.03882753658754
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	36/1132	142/9376	2.0998357636988	UBE2E3/CBLB/CDC20/UBE2J1/SOCS3/BIRC3/CUL4A/UBE2I/RCHY1/UBA2/MID1/UBE2N/UBE2J2/UBC/ANAPC7/UBE2B/ITCH/UBE2G2/UBE2D3/UBE2L6/UBA6/FZR1/UBE2G1/UBE2M/UBE2C/UBE2Q2/CUL4B/SAE1/UBA3/PML/UBE2D1/UBE2E1/KEAP1/UBE2O/MGRN1/ANAPC10	4.89347005239951
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	30/1132	110/9376	2.25891423064568	LDHA/GAPDH/ALDOA/ENO1/HMOX1/SERPINE1/IFNGR2/TIMP1/PGK1/INSR/PFKL/EGLN3/PFKP/TFRC/AKT1/IFNGR1/LTBR/HK1/EIF4E/MAPK1/EGLN2/SLC2A1/MAPK3/FLT1/EIF4EBP1/MAP2K2/PIK3CB/EGLN1/VEGFA/PDHA1	4.92137203958514
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	50/1132	227/9376	1.82438006880341	TNFRSF1A/GNG11/RHOA/GNAI3/HLA-E/CALM1/PLCB3/ARHGEF1/CRKL/AKT1/CALM3/BID/CASP9/BCAR1/PXN/TSC1/CTNNB1/CXCL8/GNB2/NRAS/ATF6B/MAPK1/JAK1/RAC2/MAPK3/EIF4EBP1/MAP2K2/GNA11/HLA-F/HLA-B/PIK3CB/SP1/FADD/PPP3R1/CCL3L3/GNG2/TBK1/IL10RA/VEGFA/PPP3CB/CXCR4/PTGS2/ADCY5/CRK/CYCS/RAF1/TAP1/CCR1/RAC1/BAK1	4.65900802045081
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	42/1132	180/9376	1.93262661955241	TNFRSF1A/SRSF5/ALYREF/IFNGR2/SRSF3/SRSF1/IRAK1/STAT1/HLA-E/SOCS3/PPP1CC/BIRC3/AKT1/SRSF4/IFNGR1/BID/PILRA/CASP9/TSC1/EIF2B5/JAK1/EIF2S1/HCFC1/EIF4EBP1/HLA-F/HLA-B/SRSF9/PIK3CB/OAS2/FADD/TBK1/IRF9/SRSF2/PML/TNFRSF14/CYCS/IRF7/PILRB/TAP1/OAS1/BAK1/PPP1CB	4.6814936484407
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	38/1132	157/9376	2.004726429745	IGFBP3/SERPINE1/ZFP36L2/TGFB1/HLA-E/CALM1/CCNA2/PPP1CC/AKT1/CALM3/CCNB1/ETS1/TSC1/CXCL8/RASSF5/CCNE1/NRAS/MAPK1/MAP2K3/RRAS2/MYBL2/MAPK3/CCNB2/EIF4EBP1/MAP2K2/HLA-F/HLA-B/PIK3CB/VDAC2/CAPN2/PPP3R1/TGFBR1/PPP3CB/CHEK2/CAPN1/RAF1/PPID/PPP1CB	4.70430645545199
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	29/1132	108/9376	2.22405444313572	EEF1A1/ALYREF/SUMO3/THOC6/UBE2I/DDX19B/SENP2/RAN/NUP37/XPOT/NUP107/SAP18/SUMO1/RBM8A/NMD3/EIF4A3/KPNA2/THOC3/RAE1/THOC1/GLE1/ACIN1/NUP54/NUP153/IPO4/NUP160/RANGAP1/PYM1/TNPO3	4.74088542776458
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	45/1132	200/9376	1.86360424028269	GAPDH/ACTG1/TUBB6/MYO10/EZR/TNFRSF1A/MYH9/ACTB/TMBIM6/RHOA/TNFSF10/NCL/BAIAP2L1/CLDN7/CTTN/CLDN23/IRAK1/ARPC4/ARHGEF1/TUBA1A/MYO1E/CASP9/WIPF1/LPAR2/CXCL8/CLDN3/MAPK1/TUBB4B/ABCF2/ARF1/ABL1/MAPK3/TUBA1C/CDC42/CLDN15/FADD/TUBA4A/ARPC1A/SEC24C/PTPN6/TNFRSF10B/ARF6/CYCS/RAC1/BAK1	4.57449251695604
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	47/1132	214/9376	1.81909448168819	TNFRSF1A/CFL1/GNG11/TNFRSF1B/GNAI3/IRAK1/HLA-E/CALM1/CUL4A/CRKL/AKT1/CALM3/BID/CCNB1/CASP9/PXN/GNB2/NRAS/MAPK1/MAP2K3/RAC2/CFL2/AP1S2/SAMHD1/MAPK3/CCNB2/PAK4/MAP2K2/GNA11/HLA-F/HLA-B/PIK3CB/FADD/PPP3R1/GNG2/TBK1/PPP3CB/CUL4B/CXCR4/LIMK1/CRK/CYCS/RAF1/TAP1/TRIM5/RAC1/BAK1	4.49144000685132
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/1132	78/9376	2.44233034339041	CAV1/ACTG1/CAV2/ACTB/CLTB/RHOA/CTTN/CTNNA1/ARPC4/CRKL/BCAR1/PXN/CTNNB1/FN1/CDC42/DNM2/ILK/PIK3CB/RHOG/ARPC1A/CRK/MAD2L2/RAC1	4.73976850353414
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1132	116/9376	2.14207383940539	ACTG1/EZR/CD99/ACTB/RAP1A/RHOA/VASP/NCF1/ACTN1/CLDN7/CLDN23/GNAI3/CTNNA1/MYL9/BCAR1/PXN/CTNNB1/CLDN3/RASSF5/RAP1B/RAC2/CDC42/CLDN15/PIK3CB/MYL12B/VAV2/MYL12A/CYBA/CXCR4/RAC1	4.58624810110112
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1132	212/9376	1.79718647909861	ACTG1/PFN1/PGF/ACTB/RAP1A/RHOA/VASP/VEGFB/INSR/GNAI3/CALM1/PLCB3/RALB/CRKL/AKT1/CALM3/EPHA2/BCAR1/RALA/LPAR2/CTNNB1/RASSF5/NRAS/CSF1R/MAPK1/RASGRP2/LCP2/MAP2K3/RAP1B/RAC2/MAPK3/FLT1/CDC42/MAP2K2/PIK3CB/VAV2/PARD6A/VEGFA/ITGA2B/APBB1IP/ADCY5/CRK/PARD6B/RAF1/RAPGEF6/RAC1	4.3503597727905
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1132	388/9376	1.5583403154712	GAPDH/TUBB6/TNFRSF1A/COX8C/IRS1/SDHA/INSR/MT-CO1/SLC39A4/COX7B2/CSNK1E/PSMD3/CALM1/SDHC/NDUFA7/PLCB3/SLC39A1/TUBA1A/AKT1/APH1B/SDHB/CALM3/BID/CASP9/ATP2A3/CTNNB1/PSMA2/MT-CYB/ATG101/ADAM17/WNT7A/BACE2/NRAS/MAPK1/EIF2S1/CHRM3/CSNK2B/TUBB4B/PSMB1/NDUFA13/CYC1/MAPK3/PSMD4/PSMD13/TUBA1C/MAP2K2/NDUFA9/PIK3CB/VDAC2/FADD/TUBA4A/CAPN2/PPP3R1/PSMD11/APH1A/SDHD/CSNK2A2/PSMB3/APOE/PPP3CB/SLC39A6/NDUFC2/SLC39A11/FRAT2/PTGS2/CAPN1/CYCS/RAF1/PSMD8/CSNK1A1/IRS2/PPID/PSENEN	4.16220223997109
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/1132	93/9376	2.22652836353965	ACTG1/ACTB/RAP1A/RHOA/ACTN1/INSR/CTNNA1/MYL9/CTNNB1/MAPK1/CSNK2B/RAP1B/RAC2/LEF1/MAPK3/CDC42/MYL12B/FER/MYL12A/TGFBR1/CSNK2A2/YES1/PTPN6/CCM2/RAC1	4.40468398045278
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1132	138/9376	1.98064218774005	PYGL/TRIP10/SH2B2/IRS1/CBLB/INSR/SOCS3/CALM1/PPP1CC/CRKL/AKT1/CALM3/HK1/TSC1/EIF4E/NRAS/MAPK1/PRKAG1/SREBF1/MAPK3/EIF4EBP1/MAP2K2/PCK2/PRKAR1A/PIK3CB/PHKG2/PRKAA1/FLOT1/CRK/RAF1/IRS2/GYS1/PPP1CB	4.3003222104831
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	36/1132	156/9376	1.9113889643925	MX1/TNFRSF1A/CD81/CLDN7/CLDN23/SCARB1/STAT1/SOCS3/AKT1/BID/CASP9/CTNNB1/CLDN3/NRAS/MAPK1/JAK1/EIF2S1/PPP2R1B/MAPK3/EIF3E/MAP2K2/CLDN15/IFIT1B/PIK3CB/OAS2/FADD/YWHAQ/TBK1/IRF9/PPP2CA/CYCS/RAF1/IRF7/OAS1/PPP2R1A/BAK1	4.2534415023264
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1132	30/9376	3.313074204947	SDHA/SDHC/SDHB/MDH2/IDH3A/SUCLA2/PCK2/ACO2/SDHD/DLST/DLD/PDHA1	4.70194088354823
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	48/1132	232/9376	1.71365907152431	ACTG1/EZR/PFN1/TMSB4X/CFL1/RGCC/MYH9/ACTB/RHOA/PPP1R12C/ACTN1/ITGA2/PPP1CC/ARPC4/ARHGEF1/CRKL/MYL9/AKT1/BCAR1/PXN/LPAR2/SPATA13/NRAS/MAPK1/CHRM3/PIP4K2A/RRAS2/FN1/RAC2/CFL2/MAPK3/PAK4/CDC42/MAP2K2/DIAPH1/PIK3CB/MYL12B/VAV2/MYL12A/ARPC1A/ITGA2B/CXCR4/LIMK1/CRK/RAF1/RAC1/PPP1CB/DIAPH3	4.07855698354053
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	21/1132	75/9376	2.3191519434629	GAPDH/ALDOA/PKM/TPI1/ENO1/PGK1/SHMT2/PFKL/ARG2/PGAM1/PFKP/ASL/IDH3A/PYCR2/PHGDH/ACO2/SHMT1/TKT/PSPH/RPE/BCAT2	4.25011313888845
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1132	60/9376	2.48480565371025	AKT1/CASP9/PXN/NRAS/MAPK1/RAC2/HSPB1/MAPK3/CDC42/MAP2K2/PIK3CB/PPP3R1/VEGFA/PPP3CB/MAPKAPK3/PTGS2/RAF1/RAC1	4.27533704481051
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	44/1132	216/9376	1.68721371548227	CYP2J2/TNFRSF1A/ABCG1/RAP1A/HSP90AB1/ERO1A/RHOA/TNFSF10/HSPA1B/NCF1/IRAK1/SOD2/CALM1/PLCB3/ARHGEF1/MIB2/LYN/AKT1/CALM3/BID/HSPA2/CASP9/CXCL8/HSPA4/NRAS/MAPK1/EIF2S1/MAP2K3/RAP1B/TANK/MAPK3/LY96/CDC42/PIK3CB/VAV2/PPP3R1/CCL3L3/TBK1/PPP3CB/TNFRSF10B/CYBA/CYCS/IRF7/RAC1	3.78626334820056
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	40/1132	193/9376	1.71661875903989	CXCR6/RAP1A/GNG11/PPBP/PF4/RHOA/NCF1/GNAI3/STAT1/PRKCD/PREX1/PLCB3/CRKL/LYN/AKT1/BCAR1/PXN/CXCL8/GNB2/NRAS/MAPK1/RASGRP2/RAP1B/RAC2/MAPK3/GSK3A/ARRB1/CDC42/PIK3CB/VAV2/CCL3L3/GNG2/CXCR4/CCL28/CXCL16/ADCY5/CRK/RAF1/CCR1/RAC1	3.72747204448983
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	31/1132	138/9376	1.86060326727096	ACTG1/ACTB/RHOA/PKN1/IRAK1/ARPC4/ARHGEF1/CRKL/AKT1/BCAR1/PXN/WIPF1/CXCL8/MAPK1/LCP2/MAP2K3/FN1/RAC2/MAPK3/CDC42/MAP2K2/PIK3CB/VAV2/RHOG/TBK1/ARPC1A/LIMK1/ARF6/CRK/RPS6KA1/RAC1	3.77392630148668
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/1132	157/9376	1.793702595035	TNFRSF1A/COX8C/IRS1/SDHA/TGFB1/INSR/MT-CO1/COX7B2/SOCS3/SDHC/NDUFA7/AKT1/SDHB/LEPR/BID/CXCL8/MT-CYB/EIF2S1/PRKAG1/SREBF1/NDUFA13/CYC1/GSK3A/CDC42/MAP3K11/ITCH/NDUFA9/PIK3CB/SDHD/PRKAA1/NDUFC2/CYCS/IRS2/RAC1	3.71625562042773
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	34/1132	158/9376	1.78235004696516	SLC7A5/TNFRSF1A/EIF4B/IRS1/RHOA/INSR/AKT1/TSC1/EIF4E/WNT7A/LPIN3/NRAS/MAPK1/MIOS/ATP6V1B2/MAPK3/EIF4EBP1/MAP2K2/FNIP1/TTI1/PIK3CB/AKT1S1/RRAGD/LAMTOR3/PRKAA1/SLC38A9/TELO2/WDR59/RAF1/ATP6V1C1/SLC3A2/RPS6KA1/STK11/NPRL3	3.67494771541544
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	40/1132	196/9376	1.69034398211581	TNFRSF1A/GNG11/STAT1/HLA-E/CALM1/PREX1/LYN/AKT1/IFNGR1/CALM3/BID/CASP9/CTNNB1/CXCL8/GNB2/NRAS/MAPK1/UBC/JAK1/MAP1LC3A/LEF1/MAPK3/MAP2K2/HLA-F/HLA-B/PIK3CB/FADD/PPP3R1/GNG2/TBK1/IRF9/VEGFA/PPP3CB/PTGS2/CYCS/RAF1/IRF7/CCR1/RAC1/BAK1	3.61919596045574
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	82/1132	480/9376	1.41495877502945	GPX3/TUBB6/TNFRSF1A/GPX1/COX8C/SDHA/TNFRSF1B/MT-CO1/UBE2J1/COX7B2/CSNK1E/PSMD3/CALM1/SDHC/NDUFA7/PLCB3/TUBA1A/SDHB/CALM3/BID/CASP9/DERL1/ATP2A3/CTNNB1/PSMA2/MT-CYB/ATG101/WNT7A/UBE2J2/NRAS/MAPK1/UBC/EIF2S1/CHRM3/MAP1LC3A/ACTR10/MAP2K3/CSNK2B/DCTN6/TUBB4B/PRNP/PSMB1/TANK/NDUFA13/CYC1/MAPK3/PSMD4/PSMD13/TUBA1C/MAP2K2/HAP1/SIGMAR1/MFN1/UBE2G2/NDUFA9/DNAL4/UBE2L6/UBE2G1/VDAC2/FADD/TUBA4A/CAPN2/PPP3R1/TBK1/PSMD11/HTRA2/SDHD/CSNK2A2/PSMB3/PPP3CB/NDUFC2/TRAP1/FRAT2/PTGS2/CAPN1/CYCS/RAF1/PSMD8/CSNK1A1/RAC1/PPID/BAK1	3.4583428406114
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	41/1132	204/9376	1.66465738238758	CAV1/ACTG1/FLNA/IGF2/TIMP3/CD63/EZR/CAV2/ACTB/EIF4B/TGFB1/RHOA/PPP1R12C/CTTN/ITGA2/PPP1CC/ARHGEF1/SDC4/AKT1/PXN/CTNNB1/LUM/WNT7A/NRAS/MAPK1/PLAUR/RRAS2/FN1/MAPK3/COL1A2/CDC42/MAP2K2/DCN/PIK3CB/VAV2/VEGFA/PTPN6/HPSE/RAF1/RAC1/PPP1CB	3.5564831350738
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/1132	250/9376	1.59027561837456	CAV1/CAV2/CLTB/RHOA/HSPA1B/RUFY1/CBLB/ARF5/RAB7A/HLA-E/ARPC4/TFRC/WIPF1/ARF4/IL2RG/SH3GL1/CAPZA1/RAB11B/EPN1/ASAP2/ASAP1/ARF1/ARRB1/CDC42/DNM2/HLA-F/MVB12A/CAPZB/ITCH/HLA-B/ARFGAP2/PARD6A/ACAP1/TGFBR1/ARPC1A/ARFGAP1/CHMP7/VPS37A/IGF2R/ACAP2/CXCR4/PML/RAB5C/ARF6/PARD6B/SNX5/ARFGEF2/CHMP6	3.50529422247287
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	30/1132	137/9376	1.81372675453303	ACTG1/TNFRSF1A/ACTB/BIRC5/TNFSF10/LMNA/BIRC3/TUBA1A/AKT1/BID/CASP9/LMNB2/NRAS/MAPK1/CTSH/EIF2S1/CTSZ/MAPK3/TUBA1C/MAP2K2/PIK3CB/FADD/TUBA4A/CAPN2/HTRA2/TNFRSF10B/CAPN1/CYCS/RAF1/BAK1	3.55521815889097
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	45/1132	233/9376	1.59966029208814	ACTG1/DSP/PDLIM2/ENO1/SYNE1/PDLIM4/MYH9/ACTB/PKP2/TPM1/TNNT3/ITGA2/FHL2/TPM4/EMD/LMNA/MYL9/SDC4/TMEM43/CSRP1/PLEC/TPM3/NEBL/SYNE3/SUN2/LMNB2/ATP1A1/MYL4/CAPZA1/TNNI2/FN1/SUN1/COL1A2/TMOD1/ZYX/PDLIM5/CAPZB/ATP1B1/DCN/DIAPH1/ATP1B3/INF2/ITGA2B/JUP/DIAPH3	3.43462045986764
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1132	253/9376	1.57141859523178	ACTG1/TNFRSF1A/PFN1/ACTB/RHOA/ACTN1/CTTN/TNIP1/PRKCD/PLCB3/ARPC4/CRKL/MYL9/AKT1/HK1/BCAR1/PXN/CXCL8/UBE2N/ATG5/MAPK1/UBC/UBE2V2/MAP1LC3A/CAPNS1/ARF1/MAPK3/GSK3A/CDC42/DIAPH1/ILK/UBE2D3/PIK3CB/MYL12B/AKT1S1/CAPN2/MYL12A/TBK1/RIPK2/ARPC1A/RRAGD/UBE2D1/ARF6/CAPN1/CRK/CYCS/RAC1/PPID	3.41417401322285
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1132	133/9376	1.80599909668163	KLF2/IRS1/TGFB1/TNFSF10/PRMT1/HOMER3/INSR/SOD2/CSNK1E/IL7R/PLK3/AKT1/CCNB1/USP7/FBXO32/NRAS/MAPK1/PRKAG1/CDKN2D/MAPK3/CCNB2/MAP2K2/PCK2/PIK3CB/TGFBR1/PRKAA1/RAF1/IRS2/STK11	3.46891580515879
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/1132	224/9376	1.58997980817769	TNFRSF1A/PTTG1/TSPO/TGFB1/CDC20/HLA-E/MSX1/CCNA2/AKT1/LTBR/ETS1/IL2RG/RAN/FOSL1/CCNE1/NRAS/ATF6B/MAPK1/JAK1/SLC2A1/KAT5/ANAPC7/VAC14/MAPK3/CCNB2/NFKB2/MAP2K2/HLA-F/HLA-B/BUB3/PIK3CB/VDAC2/TCF3/MAD1L1/PPP3R1/TGFBR1/MSX2/PPP3CB/CHEK2/ADCY5/ANAPC10/MAD2L1/ELK4	3.31163917823231
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	35/1132	173/9376	1.67568782042117	ACTG1/MX1/TNFRSF1A/ACTB/IFNGR2/TNFSF10/STAT1/SOCS3/AKT1/IFNGR1/BID/CASP9/CXCL8/MAPK1/JAK1/EIF2S1/RAB11B/PABPN1/MAPK3/CPSF4/KPNA2/MAP2K2/RAE1/PIK3CB/OAS2/FADD/TBK1/IRF9/TNFRSF10B/PML/CYCS/RAF1/IRF7/OAS1/BAK1	3.32387200159902
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/1132	20/9376	3.313074204947	UGP2/NANS/GMDS/UAP1/GMPPA/CYB5R1/CYB5R3/UGDH	3.83706641858319
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	64/1132	368/9376	1.44046704562913	GPX3/ACTG1/TUBB6/TNFRSF1A/PFN1/GPX1/ACTB/HNRNPA1/COX8C/ALYREF/SDHA/TNFRSF1B/CHCHD10/SRSF3/MT-CO1/COX7B2/PSMD3/SDHC/NDUFA7/TUBA1A/SDHB/BID/HNRNPA3/CASP9/DERL1/PSMA2/MT-CYB/ATG101/NUP37/EIF2S1/NUP107/MAP1LC3A/ACTR10/MAP2K3/DCTN6/TUBB4B/PSMB1/TANK/NDUFA13/CYC1/PSMD4/PSMD13/TUBA1C/HAP1/SIGMAR1/RAE1/NDUFA9/DNAL4/TUBA4A/GLE1/PPP3R1/TBK1/PSMD11/SDHD/PSMB3/NUP54/NUP153/PPP3CB/NUP160/NDUFC2/HNRNPA2B1/CYCS/PSMD8/RAC1	3.19420659526747
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1132	71/9376	2.0998357636988	LDHA/PKM/SLC16A3/SLC7A5/PFKL/PGAM1/PFKP/AKT1/HK1/NRAS/MAPK1/SLC2A1/GLS/MAPK3/MAP2K2/PIK3CB/RAF1/PDHA1	3.44697936346635
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/1132	268/9376	1.51437160487316	TUBB6/COX8C/SDHA/MT-CO1/GNAI3/SLC39A4/UBE2J1/COX7B2/PSMD3/CALM1/SDHC/NDUFA7/SLC39A1/TUBA1A/SDHB/CALM3/CASP9/PSMA2/MT-CYB/UBE2J2/UBC/EIF2S1/TUBB4B/PSMB1/NDUFA13/CYC1/PSMD4/PSMD13/TUBA1C/MFN1/UBE2G2/NDUFA9/UBE2L6/UBE2G1/VDAC2/TUBA4A/PSMD11/HTRA2/SDHD/PSMB3/TXN/SLC39A6/NDUFC2/SLC39A11/TRAP1/ADCY5/CYCS/KEAP1/PSMD8	3.16572169214373
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	26/1132	120/9376	1.79458186101296	SH2B2/RAP1A/IRS1/RHOA/ARHGDIB/IRAK1/CALM1/PRKCD/CRKL/AKT1/CALM3/ARHGDIA/NRAS/MAPK1/RAP1B/ABL1/MAPK3/CDC42/MAP2K2/PIK3CB/RIPK2/SORT1/CRK/RAF1/RPS6KA1/RAC1	3.24606682925078
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	46/1132	250/9376	1.52401413427562	CD63/AP3S1/LITAF/CLTB/CD68/RAB7A/ABCA2/KXD1/CD164/M6PR/LAPTM4A/CTSH/TFEB/CTSZ/ARL8B/ATP6V1B2/AP1S2/GGA2/NPC2/LAPTM4B/NPC1/CLN3/GGA1/VPS41/TTI1/AKT1S1/SLC36A4/IDS/NAGPA/SORT1/AP3D1/MFSD8/RRAGD/LAMTOR3/TCIRG1/IGF2R/OSTM1/BLOC1S3/VPS33A/SLC38A9/TELO2/BLOC1S4/TFE3/ATP6V0A4/ATP6V1C1/SLC15A4	3.1118068580039
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1132	73/9376	2.04230601674815	MX1/MLLT1/NELFB/SERINC5/RAN/CDK9/SMARCB1/SAMHD1/MAP1S/NELFCD/NUP153/CXCR4/CPSF6/BICD2/ELL2/TRIM5/TNPO3/CHMP6	3.31272224801022
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	23/1132	103/9376	1.84953171635391	ALYREF/DAZAP1/PPP1CC/DDX19B/NUDT21/CPSF1/SAP18/PABPN1/PPP2R1B/RBM8A/CSTF3/CPSF4/EIF4A3/ETF1/GSPT1/GLE1/ACIN1/SMG1/CPSF6/PPP2CA/PYM1/PPP2R1A/PPP1CB	3.21238759351229
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	34/1132	174/9376	1.61845578977296	HERPUD1/HSP90AB1/ERO1A/EDEM1/HSPA1B/UBE2J1/BCAP31/DERL1/DNAJB11/HSPBP1/CRYAB/HSPH1/UBE2J2/ATF6B/EIF2S1/UBXN6/RAD23B/UBE2G2/UBE2D3/UBE2G1/CAPN2/NSFL1C/NPLOC4/DERL2/SSR1/SEC24C/WFS1/UBE2D1/CAPN1/DAD1/PLAA/MOGS/RNF185/BAK1	3.05127976772258
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/1132	87/9376	1.90406563502701	TGFB1/BIRC5/RHOA/RALB/AKT1/CASP9/RALA/CTNNB1/NRAS/MAPK1/RAC2/LEF1/MAPK3/MAP2K2/PIK3CB/TGFBR1/CYCS/RAF1/RAC1/BAK1	3.13917094662846
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/1132	275/9376	1.47582396402184	CAV1/TUBB6/CAV2/COX8C/SDHA/HSPA1B/NCF1/MT-CO1/COX7B2/PSMD3/PRKCD/SDHC/NDUFA7/TUBA1A/SDHB/CASP9/PSMA2/STIP1/MT-CYB/ATF6B/MAPK1/EIF2S1/CSNK2B/TUBB4B/RAC2/PRNP/PSMB1/NDUFA13/CYC1/MAPK3/PSMD4/PSMD13/TUBA1C/NOTCH1/NDUFA9/PIK3CB/VDAC2/TUBA4A/PPP3R1/PSMD11/SDHD/CSNK2A2/PSMB3/PPP3CB/CYBA/NDUFC2/CYCS/PSMD8/RAC1	2.96761775333806
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/1132	37/9376	2.46242001719034	UGP2/NANS/GMDS/PGM2/GALE/HK1/UAP1/GNPNAT1/GMPPA/PMM1/UGDH	3.30265080443169
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	23/1132	107/9376	1.78039034377993	LDHA/PKM/PYGL/PRMT1/PFKL/PGAM1/CALM1/PFKP/PLCB3/AKT1/CALM3/PPP4C/PRKAG1/SLC2A1/PPP4R3B/PCK2/PPP3R1/PHKG2/PPP3CB/PRKAA1/PPP4R3A/GYS1/PDHA1	3.0083419155315
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1132	126/9376	1.7091255819171	ACTG1/ACTB/RAP1A/RHOA/VASP/ITGA2/GNAI3/PPP1CC/PLCB3/ARHGEF1/LYN/AKT1/MAPK1/RASGRP2/LCP2/RAP1B/SNAP23/MAPK3/COL1A2/PIK3CB/MYL12B/MYL12A/ITGA2B/APBB1IP/ADCY5/PPP1CB	2.96945958781958
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	52/1132	300/9376	1.43566548881037	FLNA/IGF2/TNFRSF1A/PGF/RAP1A/TGFB1/DUSP4/HSPA1B/VEGFB/INSR/STMN1/IRAK1/CRKL/DUSP9/AKT1/DUSP5/STK3/RPS6KA4/EPHA2/MAP3K8/NRAS/CSF1R/MAPK1/RASGRP2/MAP2K3/RAP1B/RRAS2/RAC2/DUSP3/HSPB1/MAPK3/CDC25B/ARRB1/FLT1/NFKB2/CDC42/MAP2K2/ECSIT/MAP3K11/PPP3R1/TGFBR1/VEGFA/PPP3CB/LAMTOR3/MAP4K4/MAPKAPK3/CRK/RAF1/PPM1B/RPS6KA1/RAC1/ELK4	2.84188436392217
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/1132	67/9376	1.97795474922209	LDHA/GAPDH/ALDOA/PKM/TPI1/ENO1/PGK1/PGM2/PFKL/PGAM1/ADPGK/PFKP/HK1/PCK2/DLD/PDHA1	2.97676469588478
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/1132	117/9376	1.69901241279333	ACTG1/MBD3/MORF4L2/ACTB/SMARCA1/MBD2/MRGBP/CDK2AP1/INO80C/UCHL5/SMARCB1/KAT5/MTA1/MCRS1/SMARCD2/ACTL6A/INO80/INO80B/BAZ2A/RUVBL2/MEAF6/VPS72/CHD3/SMARCC2	2.81926329241355
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1132	68/9376	1.94886717938059	CCNA2/RUNX1/PIM1/AKT1/NRAS/CSF1R/MAPK1/LEF1/MAPK3/EIF4EBP1/MAP2K2/PIK3CB/PML/JUP/PPARD/RAF1	2.90985637851221
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1132	169/9376	1.56831915027077	DAPK3/IRS1/ATG9B/RAB7A/PRKCD/AKT1/TSC1/ATG101/NRAS/ATG5/MAPK1/UBC/EIF2S1/MAP1LC3A/RRAS2/TANK/ATG4B/WDR45/MAPK3/MAP2K2/VPS41/SUPT20H/PIK3CB/AKT1S1/TBK1/RRAGD/PRKAA1/VPS33A/PPP2CA/RAF1/IRS2/STK11	2.76258997330033
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1132	77/9376	1.82864485337984	TGFB1/STAT1/RALB/AKT1/CASP9/RALA/MAPK1/JAK1/RAC2/MAPK3/CDC42/PIK3CB/TGFBR1/VEGFA/RAF1/RAC1/BAK1	2.70542523211041
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1132	42/9376	2.16927477704863	HMOX1/TFRC/FTH1/ATG5/GPX4/MAP1LC3A/PRNP/VDAC2/PCBP1/GSS/SLC3A2	2.81414964951051
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	33/1132	181/9376	1.51010288347032	TNFRSF1A/CEBPB/TGFB1/RHOA/IFNGR2/IRAK1/RAB7A/STAT1/CALM1/PLK3/AKT1/IFNGR1/CALM3/BID/CORO1A/CASP9/MAPK1/JAK1/NFYA/MAPK3/HSPA9/FCGR3A/FADD/CEBPG/PPP3R1/IL10RA/RIPK2/PPP3CB/TCIRG1/RAB5C/CYCS/RAF1/ATP6V0A4	2.56779919992577
Genetic Information Processing	Transcription	hsa03040	Spliceosome	42/1132	243/9376	1.43157527374253	SRSF5/HNRNPA1/ALYREF/HSPA1B/SRSF3/THOC6/HNRNPC/SRSF1/HNRNPM/PPIL1/SNRPA/SRSF4/HNRNPK/HNRNPA3/SART1/U2AF2/SF3B3/PLRG1/SNRNP40/DDX23/PRPF38A/XAB2/SF3B2/RBM8A/EIF4A3/THOC3/HNRNPU/SF3B4/PRPF31/SRSF9/THOC1/PPIE/ACIN1/SF3A2/SRSF2/PHF5A/U2SURP/LSM5/SNRNP70/PCBP1/BUD13/CWC25	2.52576431296563
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/1132	109/9376	1.67173469056959	PYGL/TNFRSF1A/IRS1/NR1H2/INSR/SOCS3/PRKCD/PPP1CC/AKT1/SLC27A6/TBC1D4/PRKAG1/SLC2A1/SREBF1/PCK2/PIK3CB/PRKAA1/OGT/RPS6KA1/IRS2/GYS1/PPP1CB	2.61385387311865
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	24/1132	122/9376	1.62938075653131	SCD/IRS1/INSR/PFKL/CCNA2/PFKP/AKT1/LEPR/TSC1/RAB11B/PRKAG1/SREBF1/PPP2R1B/EIF4EBP1/PCK2/ELAVL1/PIK3CB/AKT1S1/PRKAA1/PPP2CA/IRS2/STK11/PPP2R1A/GYS1	2.59279683537968
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1132	122/9376	1.62938075653131	ACTG1/ACTB/PFKL/STAT1/PFKP/PLCB3/AKT1/CASP9/ATP2A3/CTNNB1/TBC1D4/ATP1A1/NRAS/MAPK1/SLC2A1/MAPK3/MAP2K2/NOTCH1/ATP1B1/HDAC3/ATP1B3/PIK3CB/DIO2/RAF1	2.59279683537968
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/1132	142/9376	1.5748768227741	CAV1/ACTG1/TNFRSF1A/HMOX1/GSTO1/CAV2/ACTB/HSP90AB1/KLF2/SUMO3/RHOA/NCF1/CALM1/SDC4/AKT1/CALM3/CTNNB1/SUMO1/RAC2/PIK3CB/VEGFA/TXN/ITGA2B/PRKAA1/CYBA/KEAP1/RAC1	2.55778417916045
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/1132	32/9376	2.32950530035336	TNFRSF1A/BIRC5/BIRC3/BID/CASP9/FADD/HTRA2/CYCS/BAK1	2.79150562575225
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	22/1132	110/9376	1.6565371024735	HSP90AB1/GNAI3/CCNA2/STK10/AKT1/CCNB1/MAPK1/ANAPC7/MAPK3/CDC25B/CCNB2/PIK3CB/FZR1/MAD1L1/BUB1/ADCY5/RAF1/MAD2L2/KIF22/RPS6KA1/ANAPC10/MAD2L1	2.56654763319829
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1132	67/9376	1.85433257739571	RAP1A/CALM1/PPP1CC/PLCB3/CALM3/NRAS/MAPK1/RAP1B/MAPK3/MAP2K2/PPP3R1/PPP3CB/RAF1/RPS6KA1/PPP1CB	2.6004751824752
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/1132	157/9376	1.5299228016475	RAB17/CEBPB/BSG/SLC16A1/TGFB1/DUSP4/NR1H2/ARG2/RAB7A/CRKL/DUSP5/BCAR1/ATP2A3/ADAM9/ADAM17/MAPK1/SLC2A1/MAPK3/MAP2K2/HAVCR2/VPS41/PTPN6/VPS33A/RAB5C/MERTK/PTGS2/CRK/PPARD/RAC1	2.48119207664741
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1132	38/9376	2.17965408220197	UGP2/PGM2/GALE/HK1/UAP1/GNPNAT1/GMPPA/GNPDA1/PMM1/UGDH	2.69997285894635
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	36/1132	205/9376	1.45452038265966	GAPDH/COX8C/IRS1/SDHA/TGFB1/NCF1/INSR/MT-CO1/COX7B2/PRKCD/SDHC/PPP1CC/NDUFA7/PLCB3/AKT1/SDHB/ATP2A3/TBC1D4/MT-CYB/SLC2A1/RAC2/NDUFA13/CYC1/COL1A2/NDUFA9/PIK3CB/SP1/VDAC2/TGFBR1/SDHD/CYBA/NDUFC2/RAC1/GYS1/PDHA1/PPP1CB	2.43815778513227
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1132	105/9376	1.6565371024735	BNIP3L/ATG9B/FKBP8/CCZ1/RAB7A/RHOT2/NRAS/UBC/EIF2S1/TFEB/MAP1LC3A/CSNK2B/RRAS2/USP15/MFN1/SP1/TBK1/CSNK2A2/PGAM5/RAB5C/TFE3	2.50686238108805
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1132	62/9376	1.8702838253733	IRS1/HSPA1B/INSR/SOD2/AKT1/CRYAB/NRAS/ATG5/PRKAG1/PIK3CB/AKT1S1/PRKAA1/ADCY5/IRS2	2.54758392611208
Cellular Processes	Cell motility	hsa04814	Motor proteins	34/1132	194/9376	1.45160467742523	ACTG1/DYNLL1/TUBB6/MYO10/MYH9/ACTB/TPM1/TNNT3/TPM4/MYL6/TUBA1A/MYL9/MYO1E/KIF1C/TPM3/MYL4/CAPZA1/TNNI2/ACTR10/DCTN6/TUBB4B/TUBA1C/DYNLRB1/CAPZB/DNAL4/DYNLT3/MYL12B/KIF18B/TUBA4A/MYL12A/KIF9/KIF2C/KIF22/KIF4A	2.35521474845432
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1132	101/9376	1.64013574502327	SERPINE1/TGFB1/VEGFB/STAT1/PRKCD/PLCB3/PIM1/AKT1/CXCL8/NRAS/MAPK1/FN1/MAPK3/COL1A2/CDC42/DIAPH1/PIK3CB/TGFBR1/VEGFA/RAC1	2.39671098598175
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	28/1132	154/9376	1.50594282043045	RDH13/UGP2/RFK/ALAS2/SHMT2/MTHFD1L/CPOX/COQ2/NME1/NADK/GMPPA/CAD/HMBS/NME2/AK2/PMM1/DHFR/VKORC1/PHOSPHO2/SHMT1/GSS/DLD/UMPS/COQ5/COX10/BCAT2/UGDH/PTS	2.34578982941215
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/1132	46/9376	1.98064218774005	PSMB8/PSMF1/PSMD3/PSMA2/PSME2/PSMB1/PSMD4/PSMD13/PSMD11/PSMB3/PSMD8	2.47052086963579
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	23/1132	122/9376	1.56148989167584	IGFBP3/GH2/IRS1/GNAI3/STAT1/SOCS3/PLCB3/CRKL/AKT1/BCAR1/NRAS/ATF6B/MAPK1/MAP2K3/MAPK3/MAP2K2/GNA11/PIK3CB/CSH1/ADCY5/CRK/RAF1/IRS2	2.31311364246067
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/1132	83/9376	1.69645365915961	USP7/RNF2/PCGF1/WDR5/CSNK2B/HCFC1/PCGF5/USP16/AURKB/UBE2D3/PHC2/L3MBTL2/PCGF3/UBE2D1/PCGF2/RYBP/OGT	2.36152834222153
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1132	77/9376	1.72107750906337	TGFB1/CRKL/RUNX1/AKT1/CTBP1/NRAS/MAPK1/ABL1/MAPK3/MAP2K2/PIK3CB/TGFBR1/BCR/CRK/RAF1/BAK1	2.3542308618348
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1132	35/9376	2.12983341746593	ALDOA/TPI1/GMDS/PFKL/PFKP/HK1/GMPPA/PMM1/AKR1B1	2.48137048457445
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	53/1132	333/9376	1.31826526172816	PKM/MX1/LAMC2/TNFRSF1A/ISG15/HES2/ITGA2/STAT1/HLA-E/CCNA2/AKT1/LLGL2/BCAP31/CRB3/PXN/TSC1/CTNNB1/WNT7A/CCNE1/NRAS/MAPK1/TADA3/JAK1/ATP6V1B2/FN1/PPP2R1B/MAPK3/COL1A2/EIF4EBP1/CDC42/MAP2K2/HLA-F/NOTCH1/HLA-B/PIK3CB/FADD/PARD6A/TBK1/IRF9/SCRIB/VEGFA/HES6/ITGA2B/TCIRG1/PPP2CA/PTGS2/PARD6B/RAF1/CSNK1A1/ATP6V0A4/ATP6V1C1/PPP2R1A/BAK1	2.19126524156232
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/1132	90/9376	1.6565371024735	IRS1/INSR/SOD2/AKT1/TSC1/EIF4E/ATG101/NRAS/ATF6B/ATG5/PRKAG1/EIF4EBP1/PIK3CB/AKT1S1/PRKAA1/ADCY5/IRS2/STK11	2.31902830387847
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/1132	90/9376	1.6565371024735	IFNGR2/STAT1/AKT1/IFNGR1/BATF3/NRAS/MAPK1/JAK1/MAP2K3/CSNK2B/MAPK3/MAP2K2/PIK3CB/PPP3R1/CSNK2A2/PPP3CB/PTPN6/RAF1	2.31902830387847
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	20/1132	103/9376	1.6082884490034	TNFRSF1A/SERPINE1/TGFB1/IFNGR2/GNAI3/IRAK1/PLCB3/AKT1/IFNGR1/CXCL8/MAPK1/PPP2R1B/MAPK3/GNA11/PIK3CB/FADD/TGFBR1/CCL3L3/PPP2CA/PPP2R1A	2.30015928686211
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1132	59/9376	1.82499850272504	CTNNA1/AKT1/CASP9/CTNNB1/NRAS/MAPK1/LEF1/MAPK3/MAP2K2/ILK/PIK3CB/RAF1/BAK1	2.35548844709591
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	39/1132	235/9376	1.37457334035035	ACTG1/ACTB/COX8C/SDHA/MT-CO1/KDM3A/COX7B2/SDHC/NDUFA7/SDHB/TSC1/MT-CYB/NRAS/PRKAG1/MAP2K3/SMARCB1/SLC25A29/NDUFA13/CYC1/NDUFA9/COA1/AKT1S1/SMARCD2/MGLL/ACTL6A/PNPLA2/KDM3B/SDHD/COX11/NDUFAF7/PRKAA1/NDUFC2/NDUFAF2/COA6/ADCY5/COX10/RPS6KA1/SMARCC2/COA3	2.15483390690659
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/1132	138/9376	1.50048650586368	PTTG1/CDC20/CALM1/PPP1CC/CALM3/CCNB1/CCNE1/MAPK1/ANAPC7/PPP2R1B/MAPK3/CCNB2/MAD1L1/PPP3R1/YWHAQ/PPP3CB/BUB1/PPP2CA/ADCY5/MAD2L2/RPS6KA1/PPP2R1A/ANAPC10/MAD2L1/PPP1CB	2.19473857449743
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1132	60/9376	1.79458186101296	CRH/GNAI3/PLCB3/LYN/NRAS/MAPK1/PPP2R1B/MAPK3/MAP2K2/GNA11/PPP2CA/RAF1/PPP2R1A	2.28791239919814
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1132	37/9376	2.01470728679209	TFG/TPM3/CTNNB1/NRAS/MAPK1/LEF1/MAPK3/MAP2K2/BAK1	2.29156042559176
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/1132	155/9376	1.44279037957369	ACTG1/TUBB6/ACTB/NCF1/ITGA2/SCARB1/RAB7A/HLA-E/TUBA1A/TFRC/CORO1A/M6PR/TUBB4B/ATP6V1B2/RILP/TUBA1C/HLA-F/HLA-B/FCGR3A/TUBA4A/TCIRG1/CYBA/RAB5C/TAP1/ATP6V0A4/ATP6V1C1/RAC1	2.05975172203789
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1132	75/9376	1.6565371024735	GSTO1/BIRC5/BIRC3/AKT1/BID/CASP9/TOP2A/MAPK1/ERCC1/MAPK3/PIK3CB/FADD/SLC31A1/CYCS/BAK1	2.11526578057826
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1132	75/9376	1.6565371024735	IGFBP3/SERPINE1/AIFM2/BID/RCHY1/CCNB1/CASP9/CCNE1/CCNB2/GTSE1/PERP/CHEK2/RRM2/TNFRSF10B/CYCS	2.11526578057826
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1132	56/9376	1.77486118122161	MGAT4B/B4GALT3/MGAT4A/MGAT1/ALG3/ST6GAL1/DPM1/MGAT3/DHRSX/DPAGT1/DAD1/MOGS	2.15501263930706
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/1132	142/9376	1.45821928034639	TNFRSF1A/TGFB1/IFNGR2/NCF1/FHL2/STAT1/SOCS3/AKT1/IFNGR1/ATP2A3/FOSL1/CSF1R/MAPK1/JAK1/LCP2/MAPK3/NFKB2/PIK3CB/FCGR3A/PPP3R1/TGFBR1/IRF9/PPP3CB/CYBA/RAC1	2.03874287399621
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1132	69/9376	1.68054488656732	ALOX5AP/LYN/AKT1/NRAS/MAPK1/LCP2/MAP2K3/RAC2/MAPK3/MAP2K2/PIK3CB/VAV2/RAF1/RAC1	2.10240472364467
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/1132	136/9376	1.46165038453544	MX1/HSPA1B/CBLB/IRAK1/STAT1/AKT1/BID/RCHY1/CASP9/IL2RG/CCNE1/JAK1/EIF2S1/CSNK2B/PIK3CB/OAS2/FADD/TBK1/IRF9/CSNK2A2/CYCS/IRF7/OAS1/BAK1	2.00949315089961
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1132	57/9376	1.74372326576158	SCD/MCAT/ACOX1/ACOX3/ELOVL1/ACAT1/HSD17B12/ACADVL/TECR/MECR/CBR4/ACSF3	2.08691134353988
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1132	27/9376	2.14736291061379	SCD/ACOX1/ACOT7/ACOX3/ELOVL1/HSD17B12/TECR	2.21227936831785
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/1132	158/9376	1.41539562553115	PTTG1/TGFB1/CDC20/CCNA2/CCNB1/MAD2L1BP/CCNE1/CDKN2D/ANAPC7/ABL1/PPP2R1B/CDC25B/CCNB2/AURKB/BUB3/FZR1/TRIP13/MAD1L1/YWHAQ/BUB1/CHEK2/CDC14A/PPP2CA/MAD2L2/PPP2R1A/ANAPC10/MAD2L1	1.95124575113277
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1132	39/9376	1.9113889643925	SHMT2/MTHFD1L/TYMS/ATIC/AHCY/MTHFS/DHFR/SHMT1/DLD	2.11335399802822
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	31/1132	187/9376	1.37306551274541	TXNIP/GBP2/HSP90AB1/RHOA/PKN1/STAT1/PRKCD/BIRC3/PLCB3/TRIP6/CXCL8/GBP1/ATG5/MAPK1/JAK1/MAP1LC3A/TANK/NAMPT/MAPK3/MFN1/OAS2/VDAC2/FADD/TBK1/IRF9/RIPK2/TXN/GSDMD/CYBA/IRF7/OAS1	1.90946473074465
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	28/1132	166/9376	1.39707948401379	IRS1/RHOA/VASP/INSR/GNAI3/CALM1/PPP1CC/PLCB3/ADRA2C/MYL9/AKT1/CALM3/ATP2A3/ATP1A1/ATF6B/MAPK1/MAPK3/MAP2K2/GNA11/ATP1B1/ATP1B3/VDAC2/PPP3R1/PPP3CB/ADCY5/RAF1/IRS2/PPP1CB	1.91267656999306
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1132	238/9376	1.32244558600825	IGF2/PGF/RAP1A/GNG11/RHOA/VEGFB/INSR/RGL2/CALM1/RALB/AKT1/CALM3/ETS1/EPHA2/RALA/RASSF5/GNB2/NRAS/CSF1R/MAPK1/RASGRP2/RAP1B/RRAS2/RAC2/ABL1/MAPK3/FLT1/PAK4/CDC42/MAP2K2/PIK3CB/GNG2/TBK1/VEGFA/RAB5C/ARF6/RAF1/RAC1	1.86706396913178
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/1132	91/9376	1.54731487593678	DAPP1/CD81/LYN/AKT1/IFITM1/NRAS/MAPK1/RAC2/MAPK3/MAP2K2/PIK3CB/VAV2/PPP3R1/PPP3CB/PTPN6/RAF1/RAC1	1.94404742156298
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1132	125/9376	1.45775265017668	TNFRSF1A/RHOA/GNAI3/PLCB3/AKT1/BID/DEGS2/NRAS/MAPK1/RAC2/SPTLC2/ORMDL2/PPP2R1B/SPTSSA/MAPK3/MAP2K2/CERS2/PIK3CB/PPP2CA/RAF1/RAC1/PPP2R1A	1.90911193834722
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	19/1132	105/9376	1.49877166414269	RHOA/CBLB/STAT1/CALM1/PRKCD/PLK3/AKT1/CALM3/NRAS/MAPK1/RRAS2/MAPK3/NFKB2/PIK3CB/PPP3R1/IRF9/PPP3CB/PTGS2/RAF1	1.90446498283387
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1132	85/9376	1.55909374350447	UPP1/TK1/TYMS/NME1/NT5C3B/HPRT1/GMPS/NME2/NT5C/IMPDH2/AK2/DCTD/ITPA/NUDT16/RRM2/UCK2	1.91868078053261
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1132	59/9376	1.68461400251542	UPP1/TK1/TYMS/NME1/NT5C3B/CAD/NME2/NT5C/DCTD/RRM2/UMPS/UCK2	1.95467066706014
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	33/1132	205/9376	1.33331035077135	ISG15/IRAK1/STAT1/HLA-E/PSMD3/CCNA2/LYN/AKT1/BID/CASP9/USP7/CCNE1/JAK1/MAP2K3/NCOR2/PSMD4/PSMD13/NFKB2/HLA-F/HLA-B/PIK3CB/OAS2/FADD/TBK1/PSMD11/IRF9/CYCS/IRF7/TAP1/PSMD8/OAS1/RAC1/BAK1	1.78795771895417
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/1132	205/9376	1.33331035077135	PKM/RHOA/ACTN1/CDC20/HLA-E/CCNA2/LYN/HNRNPK/LTBR/PXN/USP7/CCNE1/NRAS/ATF6B/MAPK1/JAK1/VAC14/MAPK3/NFKB2/CDC42/HLA-F/HLA-B/HDAC3/PIK3CB/MAD1L1/YWHAQ/IRF9/SCRIB/GTF2A1/GTF2H1/IRF7/RAC1/BAK1	1.78795771895417
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/1132	47/9376	1.76227351326968	PKM/IRS1/INSR/SOCS3/PRKCD/HK1/MAPK1/MAPK3/PIK3CB/IRS2	1.94125269695869
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1132	48/9376	1.72555948174323	CD63/CD81/CD9/CLDN7/CLDN23/SCARB1/CLDN3/CLDN15/EPCAM/CHMP7	1.86740807299117
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1132	122/9376	1.4257081619649	RHOA/CBLB/AKT1/MAP3K8/NRAS/MAPK1/LCP2/PTPRC/PPP2R1B/MAPK3/PAK4/CDC42/MAP2K2/PIK3CB/VAV2/PPP3R1/PPP3CB/PTPN6/PPP2CA/RAF1/PPP2R1A	1.75374725662266
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1132	109/9376	1.44377086912828	IRAK1/STAT1/TOLLIP/AKT1/MAP3K8/CXCL8/MAPK1/JAK1/MAP2K3/MAPK3/LY96/MAP2K2/PIK3CB/FADD/CCL3L3/TBK1/IRF9/IRF7/RAC1	1.7268011036688
NA	NA	hsa04517	IgSF CAM signaling	45/1132	299/9376	1.24655802025598	ACTG1/DYNLL1/TUBB6/EZR/MYH9/ACTB/RAP1A/RHOA/ACTN1/MYL6/ARPC4/CADM1/TUBA1A/MYL9/LYN/AKT1/BCAR1/PXN/CTNNB1/MPDZ/MAPK1/CSK/LCP2/TUBB4B/RAP1B/CD48/ABL1/MAPK3/TUBA1C/PAK4/CDC42/MAP2K2/GLDN/PIK3CB/MYL12B/VAV2/TUBA4A/PARD6A/MYL12A/ARPC1A/PTPN6/ARF6/PARD6B/RAPGEF6/RAC1	1.60554846881186
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1132	31/9376	1.8702838253733	ALDOA/PGM2/PFKL/PFKP/TKT/RPE/H6PD	1.79842348887694
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1132	31/9376	1.8702838253733	SHMT2/MDH2/ACAT1/HYI/ACO2/SHMT1/DLD	1.79842348887694
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1132	70/9376	1.53821302372539	CAV1/ACTG1/ACTB/HLA-E/BID/CASP9/EIF4G1/RAC2/ABL1/HLA-F/HLA-B/CYCS/RAC1	1.67479462581883
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/1132	140/9376	1.36072690560323	SERPINE1/GNG11/KLF2/GNAI3/CALM1/PLCB3/AKT1/CALM3/MYL4/GNB2/NRAS/MAPK1/MAP1LC3A/PRKAG1/RRAS2/MAPK3/MAP2K2/NRF1/TGFBR1/GNG2/PRKAA1/ADCY5/RAF1	1.5934573806256
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/1132	133/9376	1.37006828024124	IFNGR2/TNFSF10/HLA-E/IFNGR1/BID/NRAS/MAPK1/LCP2/RAC2/CD48/MAPK3/MAP2K2/HLA-B/PIK3CB/FCGR3A/VAV2/PPP3R1/PPP3CB/PTPN6/TNFRSF10B/RAF1/RAC1	1.5927259864211
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1132	112/9376	1.40509843513377	LAMC2/TNFRSF1A/TGFB1/IFNGR2/HSPA1B/GNAI3/IRAK1/STAT1/BIRC3/AKT1/IFNGR1/CASP9/MAPK1/JAK1/MAP2K3/MAPK3/LY96/IL10RA/CYCS	1.59812285975913
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1132	184/9376	1.3054232601014	EFNB1/CFL1/RHOA/GNAI3/MYL9/SEMA4C/RHOD/EPHA2/NRAS/MAPK1/RAC2/CFL2/ABL1/RYK/MAPK3/PAK4/CDC42/ILK/PIK3CB/MYL12B/PARD6A/MYL12A/PPP3R1/PPP3CB/CXCR4/LIMK1/PARD6B/RAF1/RAC1	1.55040754166884
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1132	38/9376	1.74372326576158	IRS1/INSR/ATP1A1/MAPK1/MAPK3/ATP1B1/ATP1B3/PIK3CB	1.70222157700243
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1132	51/9376	1.62405598281716	ACTG1/ACTB/ERO1A/KDELR3/ATP6V1B2/ARF1/TCIRG1/ATP6V0A4/ATP6V1C1/KDELR2	1.65586176844545
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/1132	78/9376	1.48663586119417	ENO1/PFKL/PFKP/EXOSC6/CNOT10/EXOSC7/HSPA9/CNOT8/PNPT1/DDX6/NUDT16/LSM5/MPHOSPH6/EXOSC1	1.59917687244688
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/1132	78/9376	1.48663586119417	EEF1A1/TGFB1/IFNGR2/NCF1/IRAK1/STAT1/IFNGR1/MAPK1/JAK1/MAPK3/FCGR3A/PTPN6/CYBA/PTGS2	1.59917687244688
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1132	32/9376	1.81183745583039	UGP2/PGM2/GALE/PFKL/PFKP/HK1/AKR1B1	1.70458051167197
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	24/1132	149/9376	1.33412384091825	AGPAT2/RHOA/INSR/AGPAT5/DGKD/PLCB3/RALB/AKT1/RALA/LPAR2/TSC1/CXCL8/NRAS/MAPK1/RRAS2/DGKZ/ARF1/MAPK3/MAP2K2/DNM2/PIK3CB/ADCY5/ARF6/RAF1	1.52338683862302
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/1132	157/9376	1.3188989669375	ACTG1/SERPINE1/ACTB/TGFB1/BIRC5/CTNNA1/CSNK1E/PPP1CC/BIRC3/LLGL2/STK3/CTNNB1/WNT7A/LEF1/TEAD4/PPP2R1B/PARD6A/YWHAQ/TGFBR1/SCRIB/PPP2CA/YAP1/PARD6B/PPP2R1A/PPP1CB	1.49314124162315
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1132	52/9376	1.59282413699375	TSPO/SCARB1/ANGPTL4/NPC2/NPC1/STARD3/VDAC2/SORT1/APOE/VAPA	1.58842340338875
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	45/1132	308/9376	1.21013262356019	GPX3/TUBB6/GPX1/COX8C/CLTB/SDHA/MT-CO1/COX7B2/SOD2/PSMD3/SDHC/NDUFA7/PLCB3/TUBA1A/TGM2/SDHB/CASP9/POLR2E/PSMA2/MT-CYB/ATG101/ACTR10/DCTN6/TUBB4B/POLR2C/PSMB1/NDUFA13/CYC1/PSMD4/PSMD13/TUBA1C/HAP1/NDUFA9/DNAL4/NRF1/SP1/VDAC2/TUBA4A/PSMD11/POLR2H/SDHD/PSMB3/NDUFC2/CYCS/PSMD8	1.38948206504518
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/1132	110/9376	1.35534853838741	GREM2/INHBA/TGFB1/RHOA/TFRC/SKIL/TGIF1/MAPK1/PPP2R1B/MAPK3/DCN/SP1/NOG/TGFBR1/FST/PPP2CA/PPP2R1A/SKI	1.38913543000487
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1132	139/9376	1.31092864224521	KRT19/KRT18/KRT23/HSP90AB1/HSPA1B/GNAI3/CALM1/PRKCD/PLCB3/AKT1/CALM3/FKBP5/NRAS/ATF6B/MAPK1/MAPK3/FKBP4/MAP2K2/PIK3CB/SP1/ADCY5/RAF1	1.368492806197
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1132	41/9376	1.61613375851073	DAPK3/CXCL8/NRAS/MAPK1/MAPK3/MAP2K2/VEGFA/RAF1	1.4650405050414
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1132	119/9376	1.32244558600825	TNFRSF1A/CEBPB/TNFRSF1B/SOCS3/BIRC3/AKT1/RPS6KA4/MAP3K8/ADAM17/ATF6B/MAPK1/MAP2K3/RHBDF1/MAPK3/ITCH/PIK3CB/FADD/PGAM5/PTGS2	1.31170038228325
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/1132	163/9376	1.27035053870667	TGFB1/BIRC5/IRAK1/STAT1/CCNA2/AKT1/BID/CASP9/CXCL8/CCNE1/NRAS/ATF6B/MAPK1/JAK1/MAP2K3/MAPK3/MAP2K2/PIK3CB/FADD/YWHAQ/TGFBR1/TBK1/CYCS/RAF1/IRF7	1.29020988812986
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1132	49/9376	1.52130958390423	GALNT7/B4GALT3/GALNT3/COLGALT1/ST6GAL1/C1GALT1C1/GALNT2/PLOD3/OGT	1.3556969559564
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1132	56/9376	1.47905098435134	EEF1A1/HSPA1B/CASP9/CXCL8/HSF1/ARF1/NFKB2/CLK1/RAB1B/CYCS	1.33231726039245
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1132	70/9376	1.41988894497728	TNFRSF1A/IRS1/TNFRSF1B/SOCS3/AKT1/LEPR/PRKAG1/SLC2A1/PCK2/PRKAA1/IRS2/STK11	1.30659742051782
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1132	23/9376	1.80058380703641	ATP1A1/GLS/PCK2/ATP1B1/ATP1B3	1.42441032331706
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/1132	100/9376	1.3252296819788	TNFRSF1A/PPBP/PF4/TNFRSF1B/TNFSF10/LTBR/CXCL8/IL2RG/CSF1R/CCL3L3/IL10RA/TNFRSF10B/CXCR4/CCL28/TNFRSF14/CCR1	1.2115732178235
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1132	130/9376	1.274259309595	GNG11/TGFB1/VEGFB/GNAI3/PLCB3/AKT1/GNB2/NRAS/ATF6B/MAPK1/MAPK3/ARRB1/COL1A2/MAP2K2/PIK3CB/TGFBR1/GNG2/VEGFA/ADCY5/RAF1	1.16679879001363
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1132	65/9376	1.4016852405545	PLCB3/AKT1/NRAS/MAPK1/MAPK3/ARRB1/MAP2K2/GNA11/KCNN4/PIK3CB/RAF1	1.20416014645728
Genetic Information Processing	Translation	hsa03010	Ribosome	32/1132	222/9376	1.19390061439531	RPL4/MRPS9/MRPS6/MRPS17/MRPS2/RPL17/MRPL28/RPL8/MRPL50/MRPL39/MRPS28/MRPL32/MRPL37/MRPS18A/MRPL53/DAP3/MRPL24/MRPL18/MRPL44/MRPS35/RPL29/MRPS7/RPL19/MRPL11/MRPL10/MRPL9/MRPL34/MRPS30/RPS10/MRPL3/MRPS14/MRPS25	1.0834031112739
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1132	31/9376	1.60310042174855	SGTA/SRP9/SEC11A/BAG6/SRP72/UBL4A	1.2462945225472
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1132	18/9376	1.84059678052611	MCAT/MECR/CBR4/ACSF3	1.32273338350567
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1132	18/9376	1.84059678052611	PRDX1/HCFC1/CD320/ZNF143	1.32273338350567
NA	NA	hsa04518	Integrin signaling	23/1132	154/9376	1.2370244596393	FLNB/ACTG1/FLNA/LAMC2/PGF/ACTB/TGFB1/VEGFB/ACTN1/ITGA2/AKT1/PXN/CTNNB1/FN1/RAC2/FLT1/COL1A2/CDC42/ILK/PIK3CB/VEGFA/ITGA2B/RAC1	1.09895732144342
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1132	154/9376	1.2370244596393	ACTG1/ACTB/RHOA/PPP1R12C/GNAI3/MYL6/CALM1/PPP1CC/PLCB3/MYL9/CALM3/NRAS/MAPK1/PRKAG1/MAPK3/MAP2K2/PPP3R1/PPP3CB/PRKAA1/PTGS2/ADCY5/RAF1/PPP1CB	1.09895732144342
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1132	59/9376	1.40384500209618	IRS1/INSR/GNAI3/AKT1/PIK3CB/MGLL/PNPLA2/PTGS2/ADCY5/IRS2	1.15303510698858
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1132	12/9376	2.07067137809187	COQ2/VKORC1/COQ5	1.37516868315242
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	50/1132	362/9376	1.14401733596236	IGF2/LAMC2/GH2/PGF/EIF4B/HSP90AB1/GNG11/IRS1/VEGFB/INSR/PKN1/ITGA2/IL7R/AKT1/CDC37/CASP9/EPHA2/LPAR2/TSC1/EIF4E/IL2RG/CCNE1/GNB2/NRAS/CSF1R/ATF6B/MAPK1/JAK1/FN1/PPP2R1B/MAPK3/FLT1/COL1A2/EIF4EBP1/MAP2K2/PCK2/PIK3CB/YWHAQ/GNG2/VEGFA/CSH1/ITGA2B/PRKAA1/PPP2CA/IL4R/RAF1/RAC1/STK11/PPP2R1A/GYS1	1.0355000913363
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1132	170/9376	1.21804198711287	ACTG1/IGF2/HMOX1/GSTO1/ACTB/TGFB1/AKT1/CTNNB1/WNT7A/NRAS/MAPK1/SMARCB1/LEF1/MAPK3/MAP2K2/PIK3CB/SMARCD2/TGFBR1/ACTL6A/FRAT2/RAF1/KEAP1/CSNK1A1/SMARCC2/BAK1	1.06308739013184
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1132	89/9376	1.30289435026005	TUBB6/GNAI3/PLCB3/TUBA1A/NRAS/MAPK1/TUBB4B/MAPK3/TUBA1C/MAP2K2/GNA11/TUBA4A/ADCY5/RAF1	1.06386938985469
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1132	46/9376	1.44046704562913	HMOX1/BLVRA/ALAS2/CPOX/FTH1/BLVRB/HMBS/COX10	1.10966368999621
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1132	76/9376	1.30779244932118	ACTG1/EZR/ACTB/GNAI3/CALM1/PLCB3/CALM3/ATP1A1/CHRM3/ATP1B1/ATP1B3/ADCY5	0.99830476390838
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1132	33/9376	1.50594282043045	IDH3A/ACO2/DLST/DLD/BCAT2/PDHA1	1.07883516262115
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1132	33/9376	1.50594282043045	STX3/SNAP23/STX4/GOSR2/VTI1A/STX11	1.07883516262115
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/1132	62/9376	1.33591701812379	APH1B/CTBP1/ADAM17/NCOR2/TLE3/NOTCH1/ITCH/APH1A/DTX3L/PSENEN	0.983330691585107
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/1132	99/9376	1.25495235035871	DGKD/AKT1/SLC44A1/TSC1/NRAS/MAPK1/RAC2/DGKZ/MAPK3/EIF4EBP1/MAP2K2/PIK3CB/SP1/RAF1/RAC1	0.944958419877082
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/1132	183/9376	1.17677499082817	POP1/IMP4/RIOK1/RRP7A/NAT10/RAN/UTP18/UTP14A/NOB1/CSNK2B/GNL2/GTPBP4/NMD3/WDR3/POP4/NOP58/TBL3/GNL3/MDN1/EMG1/UTP15/DKC1/CSNK2A2/BMS1/RPP25L/HEATR1	0.894865156585087
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1132	48/9376	1.38044758539458	PLCB3/AKT1/HK1/ATP1A1/ATP1B1/ATP1B3/PIK3CB/SLC37A4	0.979176635675567
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1132	41/9376	1.41411703869689	ALAS2/SHMT2/PGAM1/PHGDH/SHMT1/PSPH/DLD	0.984685917852
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1132	34/9376	1.46165038453544	POLR2E/POLR1E/POLR2C/POLR2H/POLR1C/POLR3D	0.999246391873073
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/1132	138/9376	1.20038920469094	COX8C/SDHA/MT-CO1/COX7B2/SDHC/NDUFA7/SDHB/MT-CYB/ATP6V1B2/NDUFA13/CYC1/NDUFA9/SDHD/COX11/TCIRG1/NDUFC2/CYCS/COX10/ATP6V0A4/ATP6V1C1	0.87874880200639
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1132	63/9376	1.31471198609008	CUL4A/POLR2E/POLD2/POLR2C/ERCC1/RAD23B/POLR2H/CUL4B/RPA1/GTF2H1	0.92870678199304
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/1132	78/9376	1.274259309595	CFL1/RHOA/GNAI3/IRAK1/CALM1/CALM3/CXCL8/MAPK1/CFL2/IRF8/MAPK3/LY96	0.901267621094154
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/1132	154/9376	1.18324078748107	TPM1/GNAI3/TPM4/CALM1/PPP1CC/PLCB3/AKT1/CALM3/TPM3/ATP2A3/ATP1A1/MYL4/ATF6B/MAPK1/PPP2R1B/MAPK3/ATP1B1/ATP1B3/PPP2CA/ADCY5/PPP2R1A/PPP1CB	0.84959081984968
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1132	86/9376	1.25203385652067	CBLB/CRKL/AKT1/NRAS/MAPK1/ABL1/MAPK3/PAK4/EIF4EBP1/MAP2K2/PIK3CB/CRK/RAF1	0.870041790696317
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1132	86/9376	1.25203385652067	ACTG1/DSP/ACTB/PKP2/ITGA2/CTNNA1/EMD/LMNA/ATP2A3/CTNNB1/LEF1/ITGA2B/JUP	0.870041790696317
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/1132	155/9376	1.17560697594893	CYP11A1/CRH/RAP1A/HSD3B1/GNAI3/SCARB1/PLCB3/CTNNB1/WNT7A/CCNE1/ATF6B/MAPK1/WDR5/RAP1B/LEF1/MAPK3/MAP2K2/GNA11/SP1/RBBP5/ADCY5/ASH2L	0.81688037454862
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1132	28/9376	1.47905098435134	ACOT7/ELOVL1/HSD17B12/TECR/MECR	0.940678592705022
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1132	28/9376	1.47905098435134	ATP6V1B2/SLC4A1/TCIRG1/ATP6V0A4/ATP6V1C1	0.940678592705022
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/1132	87/9376	1.23764266276756	COX8C/TPM1/MT-CO1/COX7B2/TPM4/TPM3/ATP2A3/MT-CYB/ATP1A1/MYL4/CYC1/ATP1B1/ATP1B3	0.825162370669083
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/1132	227/9376	1.13111564265812	HMOX1/GSTO1/COX8C/SDHA/NCF1/MT-CO1/COX7B2/SOD2/PRKCD/SDHC/NDUFA7/AKT1/SDHB/MT-CYB/NRAS/MAPK1/NDUFA13/CYC1/ABL1/MAPK3/MAP2K2/NDUFA9/PIK3CB/VDAC2/SDHD/VEGFA/CYBA/NDUFC2/RAF1/KEAP1/RAC1	0.741003881422557
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1132	103/9376	1.20621633675255	SERPINB9/PRDX1/LAMC2/TGFB1/ACTN1/ARG2/RAB7A/PLCB3/CXCL8/FN1/HSPB1/COL1A2/GNA11/PIK3CB/RAB5C	0.779778775778475
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1132	134/9376	1.17441063235061	MYH9/RHOA/PPP1R12C/MYL6/CALM1/PRKCD/PPP1CC/PLCB3/ARHGEF1/MYL9/CALM3/MAPK1/MAPK3/MAP2K2/GNA11/ADCY5/RAF1/CALD1/PPP1CB	0.753498225448723
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1132	36/9376	1.38044758539458	PYGL/UGP2/GBE1/PGM2/HK1/GYS1	0.847446917695794
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1132	44/9376	1.31769996787665	DYNLL1/ARHGDIB/ARHGDIA/RAB11B/DCTN6/STX4/RAB5C	0.78270120812704
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1132	82/9376	1.21210031888305	UPP1/GSTO1/TK1/NME1/HPRT1/GMPS/NME2/IMPDH2/ITPA/RRM2/UMPS/UCK2	0.714803670039753
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1132	144/9376	1.15037298782882	INHBA/DUSP9/AKT1/SKIL/CTNNB1/PCGF1/WNT7A/NRAS/MAPK1/JAK1/MAPK3/MAP2K2/PCGF5/PIK3CB/DLX5/TCF3/KLF4/PCGF3/PCGF2/RAF1	0.673818665475748
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1132	52/9376	1.274259309595	CYP2J2/CYP11A1/CYP19A1/HSD3B1/INSR/SCARB1/PTGS2/ADCY5	0.734855210462744
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1132	30/9376	1.38044758539458	SHMT2/TYMS/ATIC/DHFR/SHMT1	0.773361292079681
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1132	83/9376	1.19749670058325	PRDX1/CROT/FAR2/MPV17/SOD2/ACOX1/ACOX3/PEX10/PEX19/AGPS/PEX3/SLC25A17	0.669669905224382
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1132	23/9376	1.44046704562913	ARG2/ASL/CAD/GLS	0.78368535731146
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1132	23/9376	1.44046704562913	NUS1/RCE1/ACAT1/GGPS1	0.78368535731146
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1132	76/9376	1.19880974521108	PLIN2/SCD/ANGPTL4/SLC27A6/FABP5/UBC/ACOX1/ACOX3/PCK2/ILK/PPARD	0.64482646079641
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1132	115/9376	1.1523736365033	RHOA/OXSR1/GNAI3/PLCB3/ARHGEF1/GCM1/ATF6B/MAPK1/MAPK3/ARRB1/GNA11/SP1/MMP15/PDE4D/ADCY5/RAF1	0.609213713146408
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1132	61/9376	1.22203556739848	HMOX1/SLC39A4/FTH1/ATP1A1/ATP1B1/ATP1B3/SLC31A1/SLC30A1/MT1F	0.644667678514032
NA	NA	hsa04981	Folate transport and metabolism	5/1132	31/9376	1.33591701812379	SHMT2/TYMS/MTHFS/DHFR/SHMT1	0.694165556217466
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1132	54/9376	1.22706452035074	LDHA/DNMT1/MDH2/AHCY/PHGDH/GSS/SMS/BCAT2	0.620056793539542
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/1132	93/9376	1.15779474904062	CALM1/PRKCD/PLCB3/CALM3/NRAS/MAPK1/MAP2K3/MAPK3/CDC42/MAP2K2/GNA11/ADCY5/RAF1	0.566669327803363
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1132	93/9376	1.15779474904062	LAMC2/ITGA2/BIRC3/AKT1/CASP9/CCNE1/FN1/CKS1B/PIK3CB/ITGA2B/PTGS2/CYCS/BAK1	0.566669327803363
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/1132	109/9376	1.13981910720654	EBI3/HSP90AB1/TGFB1/IFNGR2/STAT1/RUNX1/IFNGR1/IL2RG/MAPK1/JAK1/MAPK3/PPP3R1/TGFBR1/PPP3CB/IL4R	0.544064077735666
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1132	47/9376	1.23359145928878	LDHA/PKM/MDH2/PCK2/ACAT1/DLD/PDHA1	0.594878403141401
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/1132	133/9376	1.12096495656101	GNG11/GNAI3/CALM1/PPP1CC/PLCB3/AKT1/CALM3/GNB2/ATF6B/PPP2R1B/GSK3A/ARRB1/GNG2/PPP3CB/PPP2CA/ADCY5/PPP2R1A/PPP1CB	0.520617518570985
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1132	32/9376	1.29416961130742	LDHA/ACOX1/SUCLA2/ACOX3/DLD	0.617655397591695
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1132	32/9376	1.29416961130742	ATG9B/ATG101/ATG5/ATG4B/PPP2CA	0.617655397591695
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1132	71/9376	1.16657542427711	LYN/CXCL8/ADAM17/CSK/ATP6V1B2/CDC42/TCIRG1/ATP6V0A4/ATP6V1C1/RAC1	0.522061628558843
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1132	80/9376	1.13886925795053	AKT1/EIF4E/NRAS/MAPK1/JAK1/MAPK3/EIF4EBP1/MAP2K2/PIK3CB/VEGFA/RAF1	0.462213803328711
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1132	104/9376	1.11497689589562	LPCAT1/AGPAT2/AGPAT5/DGKD/LYPLA2/LPIN3/CRLS1/DGKZ/MBOAT7/PHOSPHO1/CEPT1/PGS1/PNPLA6/LPCAT2	0.436898343200939
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	22/1132	168/9376	1.08463738852431	PYGL/TNFRSF1A/HSP90AB1/IFNGR2/TNFSF10/STAT1/BIRC3/IFNGR1/BID/FTH1/JAK1/VDAC2/FADD/CAPN2/IRF9/SPATA2L/CHMP7/PGAM5/TNFRSF10B/CAPN1/PPID/CHMP6	0.410179640791624
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1132	144/9376	1.09285433843738	ATXN10/PSMD3/PLCB3/AKT1/ATP2A3/PSMA2/ATG101/PSMB1/KAT5/NFYA/PSMD4/PSMD13/PIK3CB/SP1/VDAC2/PSMD11/PSMB3/CYCS/PSMD8	0.416078627637113
NA	NA	hsa04382	Cornified envelope formation	28/1132	217/9376	1.06873361449903	KRT19/KRT8/COL17A1/DSP/KRT18/LAMC2/KRT23/PKP3/PKP2/S100A6/CLDN7/CLDN23/S100A16/ABCA12/PLEC/CLDN3/BLMH/SPTLC2/PPP2R1B/ELOVL1/CLDN15/S100A13/ST14/PPP2CA/JUP/CAPN1/PPL/PPP2R1A	0.379590102707991
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/1132	201/9376	1.07139215582863	IGFBP3/MLLT1/CEBPB/AFF1/CCNA2/ETV4/BIRC3/RUNX1/EWSR1/ETV5/CXCL8/HPGD/CSF1R/CDK9/FLT1/SP1/TCF3/SUPT3H/ETV7/PML/JUP/PRCC/TFE3/KDM6A/BAK1/ELK4	0.379127553916386
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1132	73/9376	1.13461445374897	AKT1/CASP9/RASSF5/NRAS/MAPK1/MAPK3/MAP2K2/PIK3CB/RAF1/BAK1	0.427840085994354
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1132	34/9376	1.21804198711287	BHLHE40/CSNK1E/PRKAG1/CRY1/PRKAA1	0.471953833892325
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1132	50/9376	1.15957597173145	P4HA1/CNDP2/SMOX/ARG2/P4HA2/PYCR2/SMS	0.419222568423582
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1132	19/9376	1.30779244932118	DLST/DLD/PDHA1	0.497629717210823
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1132	99/9376	1.08762537031088	ACTG1/ACTB/TGFB1/TPM1/ITGA2/TPM4/EMD/LMNA/TPM3/ATP2A3/PRKAG1/ITGA2B/PRKAA1	0.324775713397485
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/1132	59/9376	1.12307600167695	GPX3/GPX1/GSTO1/GPX4/RRM2/PRDX6/GSS/SMS	0.351399546917031
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/1132	76/9376	1.08982704110099	CALM1/AKT1/CALM3/NRAS/MAPK1/MAPK3/MAP2K2/PIK3CB/RAF1/BAK1	0.291348157684439
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1132	44/9376	1.12945711532284	MGAT4B/B4GALT3/MGAT4A/MGAT1/ALG3/DAD1	0.31893689269484
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1132	44/9376	1.12945711532284	NTHL1/POLD2/SMUG1/NEIL2/POLG/MPG	0.31893689269484
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1132	101/9376	1.06608823426512	GNAI3/CALM1/PLCB3/CALM3/CTNNB1/WNT7A/NRAS/MAPK1/LEF1/MAPK3/MAP2K2/ADCY5/RAF1	0.247438763322923
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1132	29/9376	1.14243938101621	CSNK1E/STK3/TEAD4/YAP1	0.284664175531577
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/1132	226/9376	1.02617342631102	CRH/RAP1A/RHOA/GNAI3/CALM1/PPP1CC/MYL9/AKT1/CALM3/ATP2A3/ATP1A1/MAPK1/ACOX1/RAP1B/RRAS2/ACOX3/RAC2/MAPK3/MAP2K2/ATP1B1/ATP1B3/PIK3CB/VAV2/PDE4D/ADCY5/RAF1/RAC1/PPP1CB	0.147585642944717
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/1132	144/9376	1.03533568904594	SCD/TNFRSF1A/IRAK1/AKT1/CTNNB1/CXCL8/LPIN3/ACOX1/PRKAG1/MAP2K3/SREBF1/ACOX3/LEF1/LY96/FADD/ACADVL/TBK1/PRKAA1	0.158338589798479
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	22/1132	178/9376	1.02370270377576	RHOA/CSNK1E/PLCB3/SENP2/CTBP1/CTNNB1/WNT7A/FOSL1/CSNK2B/RAC2/LEF1/TLE3/RYK/CACYBP/PPP3R1/CSNK2A2/PPP3CB/FRAT2/NOTUM/PPARD/CSNK1A1/RAC1	0.118304440936031
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1132	71/9376	1.0499178818494	STAT1/SOCS3/AKT1/NRAS/MAPK1/MAPK3/MAP2K2/PIK3CB/RAF1	0.156446911695405
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/1132	105/9376	1.02547534915026	TNFRSF1A/IRAK1/BIRC3/UBE2I/LYN/LTBR/CXCL8/CSNK2B/LY96/NFKB2/LTB/CSNK2A2/PTGS2	0.0972727880713338
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/1132	106/9376	1.01580105340356	HSP90AB1/AKT1/CASP9/CTNNB1/ETV5/CCNE1/NRAS/MAPK1/LEF1/MAPK3/MAP2K2/PIK3CB/RAF1	0.0606232153012046
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1132	31/9376	1.06873361449903	CNDP2/SMOX/ACOX1/ACOX3	0.142036589887727
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1132	98/9376	1.01420638926949	CYP11A1/HSD3B1/SCARB1/CALM1/PLCB3/CALM3/ATP1A1/ATF6B/GNA11/ATP1B1/ATP1B3/ADCY5	0.0523852986810781
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1132	65/9376	1.019407447676	AGPAT2/AGPAT5/DGKD/LPIN3/DGKZ/MGLL/PNPLA2/AKR1B1	0.0581790732555487
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1132	65/9376	1.019407447676	CYP11A1/HSD3B1/SCARB1/PLCB3/ATF6B/GNA11/SP1/ADCY5	0.0581790732555487
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1132	23/9376	1.08035028422185	B4GALT3/POMGNT1/B4GAT1	0.142960391305857
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/1132	82/9376	1.01008359906921	HSP90AB1/HSPA1B/HLA-E/HSPA2/PSME2/HSPA4/NFYA/HLA-F/HLA-B/TAP1	0.0339829457109514
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1132	150/9376	0.993922261484099	TGFB1/CTNNA1/AKT1/CTNNB1/WNT7A/CCNE1/NRAS/MAPK1/LEF1/MAPK3/MAP2K2/PIK3CB/TGFBR1/FRAT2/JUP/RAF1/CSNK1A1/BAK1	-0.0278048640424932
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/1132	83/9376	0.99791391715271	POLR2E/SAMHD1/FADD/TBK1/POLR2H/POLR1C/GSDMD/PCBP1/IRF7/POLR3D	-0.00707346957447601
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/1132	93/9376	0.979672479957445	IFNGR2/STAT1/IFNGR1/IL2RG/MAPK1/JAK1/MAPK3/NOTCH1/PPP3R1/PPP3CB/IL4R	-0.0729997809715388
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/1132	128/9376	0.970627208480565	PGM2/NME1/ATIC/HPRT1/GMPS/NME2/NT5C/IMPDH2/AK2/ITPA/NUDT16/RRM2/PDE4D/ADCY5/HDDC3	-0.123984146623404
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/1132	94/9376	0.969250432298324	CEBPB/HSP90AB1/SRSF1/CXCL8/FOSL1/MAPK1/MAPK3/ELAVL1/FADD/TBK1/PTGS2	-0.11102531636881
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/1132	298/9376	0.972798634002893	TNFRSF1A/GH2/INHBA/CXCR6/EBI3/INHA/PPBP/TGFB1/PF4/TNFRSF1B/IFNGR2/TNFSF10/TNFRSF12A/IL7R/IFNGR1/LEPR/LTBR/CXCL8/IL2RG/TNFSF12/CSF1R/LTB/TGFBR1/CCL3L3/IL10RA/CSH1/TNFRSF10B/CXCR4/CCL28/TNFRSF14/CXCL16/GDF15/IL4R/IL13RA1/CCR1	-0.176824979690049
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1132	86/9376	0.963102966554359	PLCB3/ATP1A1/ATF6B/CHRM3/SLC2A1/GNA11/ATP1B1/KCNN4/ATP1B3/ADCY5	-0.127371621787625
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1132	69/9376	0.960311363752753	CALM1/PPP1CC/CALM3/ATF6B/PPP3R1/PPP3CB/ADCY5/PPP1CB	-0.122609952654423
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1132	78/9376	0.955694482196249	TPI1/PLCB3/PIK3C2A/PIP4K2A/SYNJ2/PIK3CB/IMPA2/INPP5K/IPMK	-0.145596255934932
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1132	26/9376	0.955694482196249	SCARB1/BTD/SLC19A2	-0.0838259618133083
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/1132	105/9376	0.946592629984856	ACTG1/ACTB/TGFB1/TPM1/ITGA2/TPM4/EMD/LMNA/TPM3/ATP2A3/ITGA2B/ADCY5	-0.203925911055755
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1132	17/9376	0.974433589690293	MYH9/TFRC	-0.0390948320413522
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1132	53/9376	0.937662510834056	CLTB/PLCB3/ATP1A1/DNM2/ATP1B1/ATP1B3	-0.168635598578039
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/1132	115/9376	0.936303579658934	GNG11/GNAI3/PLCB3/AKT1/GNB2/NRAS/MAPK1/CHRM3/MAPK3/GNA11/PIK3CB/GNG2/ADCY5	-0.25466828541087
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1132	36/9376	0.920298390263055	UGP2/AKR1B1/RPE/UGDH	-0.177535319187045
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1132	36/9376	0.920298390263055	GALNT7/GALNT3/C1GALT1C1/GALNT2	-0.177535319187045
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1132	36/9376	0.920298390263055	POLD2/RNASEH1/RNASEH2A/RPA1	-0.177535319187045
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/1132	98/9376	0.929689190163698	DGKD/CALM1/PLCB3/CALM3/PIK3C2A/PIP4K2A/SYNJ2/DGKZ/PIK3CB/IMPA2/IPMK	-0.259267341188076
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1132	63/9376	0.920298390263055	SMYD3/COLGALT1/ACAT1/DLST/DLD/PLOD3/AASS	-0.235197351133864
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1132	63/9376	0.920298390263055	CYP2J2/PTGES3/HPGD/GPX4/LTA4H/PTGDS/PTGS2	-0.235197351133864
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1132	72/9376	0.920298390263055	ISG15/CXCL8/ATG5/TANK/AZI2/FADD/TBK1/IRF7	-0.251558125777726
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/1132	168/9376	0.93673229008918	GH2/IFNGR2/STAT1/SOCS3/IL7R/PIM1/AKT1/IFNGR1/LEPR/IL2RG/JAK1/PIK3CB/IL10RA/IRF9/CSH1/PTPN6/IL4R/IL13RA1/RAF1	-0.306615397490359
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1132	37/9376	0.895425460796486	ASL/CAD/RIMKLA/GLS	-0.236165521508046
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/1132	73/9376	0.907691562999177	AKT1/NRAS/MAPK1/MAPK3/MAP2K2/PIK3CB/RAF1/BAK1	-0.293380454509613
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1132	28/9376	0.887430590610803	B4GALT3/ST3GAL4/A4GALT	-0.221044600814773
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1132	28/9376	0.887430590610803	DHFR/AKR1B1/PTS	-0.221044600814773
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1132	19/9376	0.871861632880789	IDS/HPSE	-0.207170317316168
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1132	38/9376	0.871861632880789	NADK/NT5C/NAMPT/SIRT7	-0.293280986885391
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1132	38/9376	0.871861632880789	IL7R/IL2RG/PTPRC/TAP1	-0.293280986885391
NA	NA	hsa04519	Cadherin signaling	46/1132	404/9376	0.943078053388378	KRT19/KRT8/ACTG1/DSP/KRT18/KRT23/PKP3/ACTB/PKP2/RHOA/VASP/ACTN1/CTNNA1/PPP1CC/ARPC4/APH1B/STK3/MYO1E/FMN1/CTNNB1/MPDZ/WNT7A/NRAS/MAPK1/MAP2K3/RRAS2/RAC2/LEF1/TEAD4/RYK/MAPK3/CDC42/MAP2K2/VAV2/AMOTL2/YWHAQ/APH1A/ARPC1A/TMC6/YAP1/JUP/RAF1/CSNK1A1/RAC1/PSENEN/PPP1CB	-0.433376795332338
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1132	75/9376	0.883486454652532	GPX3/GPX1/PLCB3/ATP1A1/ATF6B/ATP1B1/ATP1B3/ADCY5	-0.37538947078364
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1132	102/9376	0.893230790549435	RAP1A/RHOA/PLCB3/ATP2A3/ATP1A1/CHRM3/RAP1B/ATP1B1/ATP1B3/ADCY5/RAC1	-0.401746800989653
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/1132	48/9376	0.862779740871614	ACAT1/AUH/ACSF3/DLD/BCAT2	-0.353170520297844
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1132	148/9376	0.895425460796486	AKT1/CTNNB1/WNT7A/NRAS/MAPK1/LEF1/MAPK3/NFKB2/MAP2K2/NOTCH1/PIK3CB/SP1/FRAT2/RAF1/CSNK1A1/BAK1	-0.475163294084189
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/1132	95/9376	0.871861632880789	TGFB1/CXCL8/ATP6V1B2/FLT1/LTB/CCL3L3/VEGFA/TCIRG1/ATP6V0A4/ATP6V1C1	-0.465139757170134
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1132	50/9376	0.828268551236749	CD81/HBB/GYPC/TGFB1/CXCL8	-0.451156262741056
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1132	21/9376	0.788827191654047	CHST15/B4GALT7	-0.358976159600334
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1132	69/9376	0.840272443283659	GNAI3/CALM1/PLCB3/CALM3/PPP3R1/PPP3CB/ADCY5	-0.493445732037605
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1132	195/9376	0.891981516716499	ACTG1/ACTB/NCF1/PLCB3/SELPLG/AKT1/MAPK1/RAC2/MAPK3/MAP2K2/HDAC3/PIK3CB/HAT1/FCGR3A/VDAC2/ITGA2B/GSDMD/CYBA/CLCN3/RAF1/RAC1	-0.564820234786595
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1132	41/9376	0.808066879255365	POLD2/MUS81/RPA1/BABAM1	-0.456377843716213
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1132	115/9376	0.864280227377477	CYP2J2/GNG11/GNAI3/PLCB3/GNB2/NRAS/MAPK1/MAPK3/GNG2/PTGS2/ADCY5/RAF1	-0.542628951596629
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/1132	97/9376	0.853885104367783	GNG11/GNAI3/CALM1/PLCB3/CALM3/GNB2/MAPK1/MAPK3/GNG2/ADCY5	-0.5360059763827
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/1132	79/9376	0.838752963277721	CLTB/STX3/STXBP1/ATP6V1B2/DNM2/TCIRG1/ATP6V0A4/ATP6V1C1	-0.533302638660613
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1132	116/9376	0.856829535762154	GNG11/HOMER3/GNAI3/PLCB3/GNB2/MAPK1/GLS/MAPK3/PPP3R1/GNG2/PPP3CB/ADCY5	-0.574932414253047
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1132	99/9376	0.83663490023914	AKT1/NRAS/MAPK1/MAPK3/MAP2K2/NOTCH1/PIK3CB/SP1/ADCY5/RAF1	-0.60549834632191
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/1132	99/9376	0.83663490023914	CYP2J2/CALM1/PRKCD/PPP1CC/PLCB3/CALM3/MAP2K3/PIK3CB/ADCY5/PPP1CB	-0.60549834632191
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1132	43/9376	0.770482373243488	ACOX1/ACOX3/ACAT1/ACADVL	-0.558958416024706
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1132	23/9376	0.720233522814564	POLD2/RPA1	-0.497764574699745
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1132	23/9376	0.720233522814564	THOP1/PREP	-0.497764574699745
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1132	12/9376	0.690223792697291	NPC1	-0.397876087644758
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1132	44/9376	0.752971410215227	TAF12/GTF2A1/GTF2H1/TAF8	-0.608591738169559
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1132	93/9376	0.801550210874273	CALM1/PLCB3/CALM3/ATP1A1/CHRM3/ATP1B1/KCNN4/ATP1B3/ADCY5	-0.712668889746441
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1132	45/9376	0.736238712210444	ABCG1/ABCA12/ABCA2/TAP1	-0.657193223699365
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/1132	149/9376	0.833827400573908	GNG11/GNAI3/NDUFA7/PLCB3/GNB2/MAPK1/NDUFA13/MAPK3/NDUFA9/ABHD6/MGLL/GNG2/NDUFC2/PTGS2/ADCY5	-0.757638695310631
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1132	13/9376	0.637129654797499	XRCC6	-0.485127062794531
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1132	56/9376	0.739525492175669	CSNK1E/CSNK1G2/ARRB1/MGRN1/CSNK1A1	-0.724421186894101
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1132	66/9376	0.752971410215227	TGFB1/IFNGR2/STAT1/IFNGR1/IL2RG/IL4R	-0.746249763448274
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1132	14/9376	0.591620393740535	B4GALT3	-0.566609178778459
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1132	26/9376	0.637129654797499	ACOX1/ACOX3	-0.686550055342126
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1132	37/9376	0.671569095597364	HBB/THOP1/PLCB3	-0.741710710928008
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1132	15/9376	0.552179034157833	AK2	-0.64317445808405
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1132	39/9376	0.637129654797499	HLA-E/HLA-F/HLA-B	-0.84143381669182
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1132	50/9376	0.662614840989399	TGFB1/LTBR/CXCR4/CCL28	-0.886345678323376
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1132	16/9376	0.517667844522968	MIF	-0.715497536643044
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1132	16/9376	0.517667844522968	A4GALT	-0.715497536643044
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1132	51/9376	0.649622393126862	LPCAT1/CEPT1/AGPS/LPCAT2	-0.929687239150509
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1132	29/9376	0.571219690508103	CALM1/CALM3	-0.856914656711393
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1132	103/9376	0.723729802051528	COL17A1/ATP1A1/COL1A2/ATP1B1/KCNN4/ATP1B3/SLC36A4/KCNE3/SLC3A2	-1.04467783752189
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1132	30/9376	0.552179034157833	PIGG/PIGL	-0.910315675692553
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1132	42/9376	0.591620393740535	ACAT1/DLST/DLD	-0.982866772105627
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1132	54/9376	0.61353226017537	ERCC1/MUS81/RPA1/TELO2	-1.05534738404742
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1132	43/9376	0.577861779932616	AGPAT2/SCARB1/ACAT1	-1.0280592134332
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1132	55/9376	0.602377128172181	DEGS2/SPTLC2/CERS2/SMPD4	-1.09587572910604
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1132	44/9376	0.56472855766142	HLA-E/HLA-F/HLA-B	-1.07235605360176
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1132	45/9376	0.552179034157833	HLA-E/HLA-F/HLA-B	-1.11580022469708
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1132	20/9376	0.414134275618375	EBP	-0.971869251758468
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1132	89/9376	0.651447175130027	GNG11/GNAI3/GNB2/GLS/HAP1/GNG2/ADCY5	-1.22423769478757
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/1132	217/9376	0.763381153213594	GSTO1/PTGES3/HSP90AB1/BIRC5/GNAI3/AKT1/NRAS/ATF6B/MAPK1/MAPK3/ARRB1/KPNA2/EIF4EBP1/MAP2K2/PIK3CB/VEGFA/KLF4/ADCY5/RAF1/RPS6KA1	-1.30675758882962
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1132	160/9376	0.724734982332155	CD99/CLDN7/CLDN23/HLA-E/CADM1/SDC4/SELPLG/CLDN3/PTPRC/HLA-F/CLDN15/HLA-B/SPN/SELL	-1.30130662412531
NA	NA	hsa04081	Hormone signaling	20/1132	219/9376	0.756409635832648	IGF2/GH2/CRH/GNG11/IRS1/RHOA/INSR/GNAI3/PLCB3/ADRA2C/LEPR/GNB2/GNA11/PIK3CB/GNG2/CSH1/DIO2/ADCY5/IRS2/STK11	-1.3515913854698
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1132	21/9376	0.394413595827023	BCAT2	-1.02944637322837
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/1132	323/9376	0.79493266527366	TIMP3/EZR/HMOX1/IRS1/RHOA/TPM1/MARCKS/STMN1/DNMT1/UBE2I/CRKL/PIM1/HNRNPK/CCNE1/NRAS/MAPK1/GLS/ABL1/MAPK3/CDC25B/PAK4/MAP2K2/NOTCH1/PIK3CB/VEGFA/ST14/PTGS2/CRK/RAF1/IRS2/BAK1	-1.38976492894421
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1132	91/9376	0.637129654797499	GNG11/GNAI3/GNB2/ARRB1/GNG2/PDE4D/ADCY5	-1.28890550936545
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1132	191/9376	0.737202375446321	CRH/GNG11/GNAI3/CALM1/PPP1CC/CALM3/GNB2/NRAS/ATF6B/MAPK1/MAPK3/HDAC3/HAT1/GNG2/ADCY5/RAF1/PPP1CB	-1.35968528868757
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1132	22/9376	0.376485705107613	CNDP2	-1.08492304049712
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1132	49/9376	0.507103194634744	GNAI3/ATF6B/ADCY5	-1.2818078149069
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1132	37/9376	0.447712730398243	MIF/FAHD1	-1.24725590034797
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1132	24/9376	0.345111896348645	B4GALT7	-1.19031068791982
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/1132	63/9376	0.525884794436031	CTNNB1/WNT7A/LEF1/BAK1	-1.39910148426077
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/1132	238/9376	0.73082519226772	MX1/TNFRSF1A/ISG15/RPL4/IRAK1/STAT1/RPL17/RPL8/CXCL8/ADAM17/MAPK1/JAK1/MAPK3/RPL29/RPL19/PIK3CB/OAS2/TBK1/IRF9/RPS10/OAS1	-1.55860897690207
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/1132	100/9376	0.579787985865724	CD9/ITGA2/IL7R/TFRC/CSF1R/ITGA2B/IL4R	-1.56540946396753
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/1132	89/9376	0.558383292968595	LAMC2/ITGA2/SDC4/FN1/COL1A2/ITGA2B	-1.55111013545075
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1132	66/9376	0.501980940143484	CYP11A1/CYP19A1/HSD3B1/HSD17B12	-1.50446798864236
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1132	54/9376	0.460149195131527	HLA-E/HLA-F/HLA-B	-1.47419842844416
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1132	90/9376	0.552179034157833	SCARB1/ATP1A1/SLC2A1/ATP1B1/ATP1B3/ADCY5	-1.58179863856224
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1132	27/9376	0.306766130087685	ACAT1	-1.33665379422604
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1132	30/9376	0.276089517078916	CYP2J2	-1.47154133161663
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1132	31/9376	0.267183403624758	UGDH	-1.51435030910149
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1132	99/9376	0.41831745011957	KRT19/KRT18/KRT23/SELPLG/FCGR3A	-2.1559551125209
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1132	68/9376	0.243608397422573	RDH13/ALDH1A1	-2.31959854576253
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1132	70/9376	0.236648157496214	GSTO1/PTGS2	-2.37537463249225
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/1132	88/9376	0.28236427883071	SERPINE1/SERPINA1/PLAUR	-2.50624856256762
NA	NA	hsa04082	Neuroactive ligand signaling	11/1132	199/9376	0.457836887618304	GNG11/GNAI3/PLCB3/ADRA2C/OGFR/GNB2/CHRM3/OGFRL1/GNA11/GNG2/ADCY5	-2.86448134477007
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/1132	254/9376	0.489134971202805	VEGFB/CALM1/PLCB3/CALM3/ATP2A3/TFEB/CHRM3/FLT1/GNA11/VDAC2/PPP3R1/PHKG2/VEGFA/PPP3CB/CXCR4	-3.05856601473113
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1132	86/9376	0.192620593310872	PLCB3/CHRM3	-2.7871407217448
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1132	73/9376	0.113461445374897	GSTO1	-2.8176523462735
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/1132	79/9376	0.104844120409715	GSTO1	-2.96060629889455
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1132	143/9376	0.231683510835454	ACTN1/SSB/TRIM21/FCGR3A	-3.43065159520435
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1132	370/9376	0.291013274758858	NPB/GH2/CRH/TSPO/ADRA2C/LEPR/CHRNB1/LPAR2/OGFR/CHRM3/NMU/OGFRL1/CSH1	-5.15599935688006
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1132	449/9376	0.0553408831561302	CALM1/CALM3/ARRB1	-7.6012564241525