category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	70/981	180/9376	3.71684222448748	NFKBIA/HLA-A/HLA-C/HLA-B/B2M/HLA-F/HLA-E/HLA-DPB1/STAT1/BST2/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/SOCS3/PILRA/OAS1/OAS2/TNF/IRF7/HLA-DMA/TAP1/IL1B/CFP/BID/CD74/STAT2/SYK/TAPBP/HLA-DQA1/HLA-DMB/JAK1/TNFRSF14/TLR2/JAK2/SP100/IFIH1/MYD88/BIRC3/HLA-DRB1/TAP2/OAS3/EIF4EBP1/IFNGR1/ITGA5/EIF2AK2/HLA-DQB1/SRSF5/HLA-DRB5/CCL5/CARD9/HLA-DOA/IRAK1/CASP8/PML/PIK3CD/TYK2/FAS/BAX/IRF9/NFKB1/RELA/SRSF3/BAK1/SRC/TRADD/TNFSF14/TICAM1/IKBKE/IL6	12.5808788781151
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	44/981	78/9376	5.39146344650932	NFKBIA/FOS/CYBA/JUN/NCF2/NCF1/HLA-DPB1/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/ITGB2/TNF/FCGR1A/PTPN6/HLA-DMA/FCGR2A/CYBB/IL1B/TGFB1/HLA-DQA1/FCGR3A/HLA-DMB/JAK1/TLR2/JAK2/ITGA4/NCF4/MYD88/HLA-DRB1/ITGAM/IFNGR1/TLR4/MARCKSL1/HLA-DQB1/HLA-DRB5/PTGS2/HLA-DOA/IRAK1/NFKB1/RELA/IL1A/EEF1A1	13.3128670286219
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	68/981	181/9376	3.5906984078711	HLA-DPB1/CEBPB/CORO1A/STAT1/HLA-DRA/HLA-DPA1/LSP1/CTSS/IFNGR2/HLA-DQA2/ITGB2/CLEC4E/FCER1G/CD14/TNF/RHOA/FCGR1A/HLA-DMA/FCGR2A/IL1B/TGFB1/BID/PLK3/CD74/SYK/HLA-DQA1/FCGR3A/HLA-DMB/JAK1/IL10RA/TLR2/CLEC7A/JAK2/CTSD/MYD88/HLA-DRB1/ITGAM/ATP6V0D1/IFNGR1/TCIRG1/TLR4/RAB7A/RIPK2/CALM3/FCGR2B/CAMK2D/HLA-DQB1/HLA-DRB5/RAB5C/SPHK1/IL18/CARD9/NOD2/VDR/HLA-DOA/IRAK1/CASP8/MRC2/BAX/CASP10/NFKB1/RELA/SRC/TRADD/CALM1/IL1A/CAMP/IL6	12.0306770973234
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	68/981	187/9376	3.475488833287	NFKBIA/CYBA/JUN/TXNIP/GBP2/PYCARD/TNFAIP3/STAT1/GBP1/CARD16/GBP4/CASP1/OAS1/OAS2/GPSM3/TNF/GBP5/RHOA/IRF7/CXCL8/NAMPT/CYBB/IL1B/GABARAP/NLRP3/IFI16/STAT2/JAK1/PSTPIP1/MYD88/CXCL2/BIRC3/OAS3/MAP1LC3B/MEFV/TLR4/CXCL3/TANK/PRKCD/PLCB2/RIPK2/P2RX7/PKN1/CASP4/NLRP12/AIM2/GBP3/CCL5/NLRC4/ITPR1/IL18/CARD9/NOD2/CASP8/TYK2/IRF9/RBCK1/GABARAPL2/NFKB1/RELA/TRPV2/CARD6/TICAM1/IKBKE/GSDMD/CAMP/IL6/CXCL1	11.6884639245324
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	70/981	205/9376	3.26356878247682	NFKBIA/HLA-A/HLA-C/HLA-B/B2M/ISG15/JUN/GADD45B/HLA-F/HLA-E/HLA-DPB1/TNFAIP3/STAT1/VIM/HLA-DRA/HLA-DPA1/HLA-DQA2/OAS1/OAS2/TNF/IRF7/HLA-DMA/TAP1/CD44/LYN/BID/STAT2/SYK/TAPBP/HLA-DQA1/HLA-DMB/JAK1/RAC1/TLR2/STAT3/MYD88/HLA-DRB1/BTK/CXCL10/CDKN1A/SAP30/TAP2/OAS3/ICAM1/ITGAL/CD58/EIF2AK2/RELB/HLA-DQB1/HLA-DRB5/RUNX3/CD40/NFKBIE/NFKB2/HLA-DOA/IRAK1/CASP8/PIK3CD/TYK2/FAS/BAX/IRF9/NFKB1/RELA/BAK1/TRADD/CDKN1B/MAP2K3/IKBKE/IL6	11.2013939438818
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	78/981	248/9376	3.00601755943573	NFKBIA/FOS/JUN/ARPC3/PYCARD/TNFSF10/CASP1/CD14/RHOB/TNF/RHOA/CXCL8/IL1B/FLNA/TUBA1A/NLRP3/PTPRC/BRK1/S100A10/RHOG/RRAS/ARPC1B/STX10/ARPC4/ACTB/RAC1/TLR2/MYL12A/MYD88/BIRC3/PFN1/CYTH1/ACTR3/GAPDH/TLR4/RAB7A/ACTR2/DYNLT1/RIPK2/CDC42/PAK1/MLKL/PKN1/CASP4/M6PR/ARF6/RAB5C/ACTG1/NLRC4/TUBA4A/ARL8A/IL18/DYNC1LI1/RILP/IRAK1/CASP8/DYNLT3/PIK3CD/DYNLL1/BAX/AHNAK/ELMO1/NFKB1/ARF1/ARPC5/RALA/RELA/TNFRSF10A/VPS41/BAK1/TRADD/RHOH/MAP2K3/FHOD1/GSDMD/RAB9A/CASP7/IL6	10.9441628461415
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	63/981	173/9376	3.48051121599406	NFKBIA/HLA-DPB1/PYCARD/MX1/TNFSF10/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/CASP1/HLA-DQA2/SOCS3/MX2/OAS1/OAS2/TNF/IRF7/CXCL8/HLA-DMA/IL1B/BID/NLRP3/STAT2/HLA-DQA1/HLA-DMB/JAK1/ACTB/JAK2/IFIH1/MYD88/RSAD2/HLA-DRB1/CALCOCO2/CXCL10/OAS3/IFNGR1/ICAM1/TLR4/ADAR/EIF2AK2/HLA-DQB1/HLA-DRB5/ACTG1/CCL5/IL18/HLA-DOA/CASP8/PML/PIK3CD/TYK2/FAS/BAX/IRF9/NFKB1/RELA/TNFRSF10A/BAK1/TRADD/IL1A/TICAM1/IKBKE/KPNA5/IL6	11.2566542613949
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	45/981	95/9376	4.52728150651859	CCL3L3/FOS/JUN/CCL3/HLA-DPB1/HLA-DRA/TNFSF13B/HLA-DPA1/HLA-DQA2/ITGB2/TNF/CXCL8/HLA-DMA/IL1B/CD86/TGFB1/ATP6V1F/VEGFA/HLA-DQA1/HLA-DMB/TLR2/CXCL2/HLA-DRB1/ATP6V1G1/ATP6V0D1/TCIRG1/ICAM1/TLR4/CXCL3/ITGAL/ATP6V0E1/HLA-DQB1/HLA-DRB5/IL15/LTB/CCL5/IL18/HLA-DOA/ACP5/CD80/CCL20/IL1A/IL6/CXCL1/TNFSF13	11.8117522560125
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	56/981	155/9376	3.45306632468515	HLA-A/HLA-C/HLA-B/CYBA/NCF2/HLA-F/HLA-E/NCF1/HLA-DPB1/CORO1A/HLA-DRA/HLA-DPA1/CTSS/HLA-DQA2/ITGB2/CD14/FCGR1A/HLA-DMA/FCGR2A/TAP1/CYBB/ATP6V1F/TUBA1A/HLA-DQA1/FCGR3A/HLA-DMB/ACTB/RAC1/TLR2/CLEC7A/NCF4/HLA-DRB1/TAP2/ITGAM/ATP6V1G1/OLR1/ATP6V0D1/TCIRG1/ITGA5/TLR4/ATP6V0E1/RAB7A/FCGR2B/HLA-DQB1/M6PR/HLA-DRB5/RAB5C/ACTG1/TUBA4A/DYNC1LI1/RILP/HLA-DOA/MARCO/MRC2/VAMP3/SEC61B	10.5267890565074
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	68/981	216/9376	3.00887227696606	CCL3L3/NFKBIA/FOS/SOD2/CYBA/JUN/CCL3/NCF2/NCF1/PYCARD/TNFSF10/CASP1/CD14/TNF/RHOA/IRF7/CXCL8/CYBB/IL1B/LYN/BID/NLRP3/HSPA1A/RAP1A/RAC1/RAP1B/TLR2/JAK2/STAT3/NCF4/MYD88/CXCL2/OLR1/HSPA6/ICAM1/TLR4/CXCL3/TANK/PLCB2/CDC42/CALM3/CAMK2D/VAV1/ERO1A/RXRA/CD40/CCL5/ITPR1/IL18/IRAK1/CASP8/PIK3CD/FAS/BAX/NFKB1/RELA/TNFRSF10A/VAV2/SRC/CALM1/NFATC1/MAP2K3/TICAM1/IKBKE/CASP7/ERN1/IL6/CXCL1	10.2103647246816
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	53/981	142/9376	3.56727110881394	NFKBIA/FOS/FOSB/CYBA/JUN/JUNB/NCF2/NCF1/TYROBP/STAT1/SPI1/IFNGR2/JUND/SOCS3/GRB2/TNF/FCGR1A/OSCAR/LILRB2/FCGR2A/IL1B/TGFB1/LILRB1/STAT2/SYK/FCGR3A/LILRB4/JAK1/RAC1/LILRA2/LILRA5/NCF4/LILRB3/BTK/IFNGR1/FYN/FCGR2B/RELB/SIRPB1/LILRA1/FOSL2/NFKB2/ITPR1/PIK3CD/TYK2/IRF9/ACP5/NFKB1/RELA/ATP2A3/IL1A/NFATC1/LILRA4	10.5373343917631
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	51/981	138/9376	3.53215441209059	NFKBIA/FOS/JUN/ARPC3/PYCARD/CASP1/WAS/TNF/RHOA/CXCL8/FCGR2A/IL1B/NLRP3/RHOG/ARPC1B/ARPC4/ACTB/RAC1/RAC2/ITGA4/WIPF1/MYD88/SKAP2/ACTR3/ITGA5/MEFV/TLR4/PTK2B/ACTR2/CDC42/PKN1/VAV1/ARF6/ACTG1/RPS6KA1/ROCK1/NLRC4/IL18/IRAK1/PIK3CD/ELMO1/NFKB1/ARPC5/RELA/VAV2/SRC/LIMK1/NFATC1/MAP2K3/TICAM1/IL6	10.2435511777072
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	62/981	196/9376	3.02332064324201	NFKBIA/HLA-A/HLA-C/HLA-B/FOS/JUN/HLA-F/HLA-E/STAT1/ZFP36/CLEC2B/IRF7/CXCL8/CD86/LYN/UBC/VEGFA/HCK/BID/STAT2/ATG3/SYK/JAK1/RAC1/JAK2/STAT3/CXCL2/CDKN1A/IFNGR1/MAP1LC3B/ICAM1/CXCL3/GNB2/EIF2AK2/CALM3/PTGS2/ITPR1/CASP8/PIK3CD/TYK2/FAS/BAX/IRF9/GNGT2/NFKB1/MICA/RELA/GNG5/MICB/BECN1/GNG11/MAPKAPK2/BAK1/SRC/TRADD/CALM1/NFATC1/CCR5/TICAM1/IKBKE/IL6/CXCL1	9.78545894601015
Human Diseases	Infectious disease: viral	hsa05162	Measles	47/981	136/9376	3.30299214487018	NFKBIA/FOS/JUN/MX1/TNFAIP3/STAT1/MSN/MX2/OAS1/OAS2/IRF7/IL1B/BID/HSPA1A/STAT2/JAK1/TLR2/IFIH1/STAT3/MYD88/EIF3H/OAS3/HSPA6/TLR4/ADAR/CSNK2B/EIF2AK2/FCGR2B/STAT5A/IL2RG/IRAK1/CASP8/PIK3CD/TYK2/FAS/BAX/IRF9/NFKB1/RELA/BAK1/TRADD/CDKN1B/BBC3/IL1A/IKBKE/RAB9A/IL6	9.24774225326916
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	31/981	66/9376	4.48917307632904	JUN/HLA-DPB1/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/TNF/HLA-DMA/IL1B/TGFB1/HLA-DQA1/HLA-DMB/TLR2/STAT3/HLA-DRB1/IFNGR1/TLR4/HLA-DQB1/HLA-DRB5/IL2RG/IL18/NOD2/HLA-DOA/NFKB1/RELA/IL12RB1/IL1A/NFATC1/IL21R/IL6	9.72365253977445
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	57/981	193/9376	2.82270919491055	CCL3L3/NFKBIA/CCL3/CXCR4/CCL4L2/NCF1/STAT1/CCL4/GNAI2/GRB2/WAS/FGR/RHOA/CXCL8/LYN/HCK/ARRB2/STAT2/RAP1A/RAC1/RAP1B/RAC2/JAK2/CXCL16/STAT3/DOCK2/CXCL2/CCR2/CXCL10/CXCL3/RASGRP2/GNB2/PTK2B/PRKCD/PLCB2/CDC42/PAK1/GNAI3/VAV1/CCL5/ROCK1/PPBP/PIK3CD/ELMO1/GNGT2/NFKB1/PF4/RELA/GNG5/CXCL9/GNG11/CXCL11/VAV2/SRC/CCL20/CCR5/CXCL1	8.74608187170633
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	40/981	109/9376	3.50737405194101	CCL3L3/NFKBIA/FOS/JUN/CCL3/CCL4L2/STAT1/CCL4/CD14/TNF/IRF7/CXCL8/IL1B/CD86/STAT2/JAK1/RAC1/TLR2/MYD88/CXCL10/MAP3K8/TLR4/CD40/IRF5/CCL5/IRAK1/CASP8/PIK3CD/TYK2/IRF9/NFKB1/RELA/CXCL9/CXCL11/CD80/MAP2K3/TOLLIP/TICAM1/IKBKE/IL6	9.00062331195416
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	40/981	109/9376	3.50737405194101	NFKBIA/FOS/JUN/HLA-DPB1/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/HLA-DMA/IL1B/TGFB1/HLA-DQA1/HLA-DMB/JAK1/JAK2/STAT3/HLA-DRB1/IFNGR1/RARA/AHR/IL27RA/IL6R/HLA-DQB1/HLA-DRB5/STAT5A/RXRA/NFKBIE/IL2RG/HLA-DOA/TYK2/NFKB1/IL1RAP/EBI3/RELA/IL12RB1/IL27/NFATC1/IL21R/IL6	9.00062331195416
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	39/981	105/9376	3.54996359400029	NFKBIA/JUN/PYCARD/STAT1/IRF1/LSP1/CASP1/CLEC4E/FCER1G/TNF/RHOA/IL1B/NLRP3/PLK3/STAT2/RRAS/SYK/CLEC7A/PRKCD/CALM3/PAK1/RELB/PTGS2/CLEC4D/BCL3/NFKB2/ITPR1/CARD9/CASP8/PIK3CD/IRF9/NFKB1/RELA/MAPKAPK2/SRC/CALM1/NFATC1/IKBKE/IL6	8.98204301725141
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	27/981	56/9376	4.60812581913499	NFKBIA/PYCARD/CASP1/ITGB2/CD14/TNF/CXCL8/IL1B/HSPA1A/TLR2/MYD88/CXCL2/ITGAM/HSPA6/TLR4/CXCL3/NLRC4/NFKB2/IL18/CASP8/NFKB1/ARF1/RELA/CASP7/EEF1A1/IL6/CXCL1	9.25715472044894
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	65/981	253/9376	2.45550841482234	NFKBIA/JUN/ARPC3/PYCARD/CASP1/CD14/TNF/RHOA/CXCL8/IL1B/CD44/UBC/NLRP3/CAPNS1/ARPC1B/HCLS1/ARPC4/ACTB/RAC1/UBE2D1/MYL12A/MYD88/PFN1/CALCOCO2/FNBP1/CYTH1/HK2/ACTR3/TLN1/ITGA5/MAP1LC3B/UBE2D3/CAPN2/TLR4/TNIP1/ACTR2/PRKCD/PLCB2/RIPK2/CDC42/CASP4/ARF6/HK1/ACTG1/CCL5/ROCK1/NLRC4/ITPR1/IL18/CAST/HK3/PIK3CD/RRAGD/DIAPH1/BAX/ELMO1/RBCK1/NFKB1/ARF1/ARPC5/RELA/BECN1/SRC/TRADD/CUL1	8.02261470827764
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	23/981	44/9376	4.99601519785006	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/TNF/HLA-DMA/IL1B/CD86/HLA-DQA1/HLA-DMB/HLA-DRB1/HLA-DQB1/HLA-DRB5/HLA-DOA/FAS/CD80/IL1A/PTPRN2	9.08188286296971
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	23/981	45/9376	4.88499263789784	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/TNF/HLA-DMA/IL1B/CD86/HLA-DQA1/HLA-DMB/HLA-DRB1/HLA-DQB1/HLA-DRB5/HLA-DOA/FAS/CD80/IL1A/IL6	8.92980867355564
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	29/981	70/9376	3.9595747779234	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/ITGB2/HLA-DMA/CD86/BID/HLA-DQA1/HLA-DMB/ACTB/RAC1/RAC2/HLA-DRB1/ICAM1/ITGAL/FYN/HLA-DQB1/HLA-DRB5/ACTG1/CD40/HLA-DOA/CASP8/CD80	8.49584548192125
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	38/981	112/9376	3.24275520605796	NFKBIA/HLA-DPB1/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/GNAI2/TNF/HLA-DMA/TGFB1/HSPA1A/HLA-DQA1/HLA-DMB/JAK1/IL10RA/TLR2/JAK2/ALOX5/STAT3/MYD88/BIRC3/HLA-DRB1/IFNGR1/HSPA6/TLR4/GNAI3/HLA-DQB1/HLA-DRB5/CD40/HLA-DOA/IRAK1/CASP8/TYK2/NFKB1/RELA/MAP2K3/CCR5	8.16209045130772
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	24/981	50/9376	4.58764525993884	CXCR4/HLA-DPB1/HLA-DRA/TNFSF13B/HLA-DPA1/HLA-DQA2/HLA-DMA/CD86/TGFB1/HLA-DQA1/HLA-DMB/ITGA4/HLA-DRB1/HLA-DQB1/HLA-DRB5/IL15/CD40/HLA-DOA/IL15RA/ITGB7/CD80/ICOSLG/IL6/TNFSF13	8.6947396539573
Human Diseases	Immune disease	hsa05330	Allograft rejection	21/981	39/9376	5.14639692621344	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/TNF/HLA-DMA/CD86/HLA-DQA1/HLA-DMB/HLA-DRB1/HLA-DQB1/HLA-DRB5/CD40/HLA-DOA/FAS/CD80	8.8697073261051
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	54/981	200/9376	2.5805504587156	NFKBIA/FOS/JUN/ARPC3/PYCARD/TNFSF10/CASP1/TNF/RHOA/CXCL8/PTPN6/FCGR2A/MYO1G/IL1B/TUBA1A/NLRP3/BRK1/ARPC1B/HCLS1/MYO1F/ARPC4/ACTB/RAC1/WIPF1/MYD88/CYTH1/ACTR3/GAPDH/TLR4/FYN/ACTR2/CDC42/PAK1/CASP4/ARF6/ACTG1/ROCK1/TUBA4A/IL18/IRAK1/CASP8/FAS/BAX/NFKB1/ARF1/ARPC5/RELA/TNFRSF10A/BAK1/SRC/TRADD/LPAR2/CASP7/IL6	7.72336308750276
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	58/981	227/9376	2.44202849739769	CCL3L3/NFKBIA/HLA-A/HLA-C/HLA-B/B2M/CCL3/HLA-F/CXCR4/CCL4L2/HLA-E/CCL4/GNAI2/GRB2/TNF/RHOA/CXCL8/TAP1/IL1B/VEGFA/BID/TAPBP/JAK1/IL10RA/RAC1/RAC2/STAT3/CDKN1A/TAP2/EIF4EBP1/PTGER4/GNB2/PTK2B/PLCB2/CALM3/IL6R/GNAI3/PTGER2/PTGS2/CCL5/ROCK1/ITPR1/CASP8/PIK3CD/FAS/BAX/GNGT2/NFKB1/RELA/GNG5/GNG11/BAK1/SRC/TRADD/CALM1/NFATC1/CCR5/IL6	7.51812858735012
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	30/981	78/9376	3.67599780443817	FOS/JUN/PYCARD/IRF1/CASP1/ITGB2/GNAI2/CD14/TNF/RHOA/CXCL8/IL1B/NLRP3/IRF8/CFL1/MYD88/ITGAM/ITGA5/TLR4/SERPING1/CALM3/GNAI3/IRAK1/NFKB1/RELA/CALM1/IL1A/TICAM1/CASP7/IL6	8.1123760617175
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/981	214/9376	2.45639105623672	NFKBIA/HLA-A/HLA-C/HLA-B/FOS/B2M/JUN/HLA-F/CXCR4/HLA-E/BST2/APOBEC3A/GNAI2/TNF/TNFRSF1B/TAP1/AP1S2/BID/TAPBP/CFL1/RAC1/RAC2/TLR2/SAMHD1/APOBEC3G/MYD88/TAP2/TLR4/GNB2/PTK2B/CALM3/PAK1/APOBEC3C/GNAI3/ITPR1/IRAK1/CASP8/PIK3CD/FAS/RNF7/BAX/GNGT2/NFKB1/RELA/GNG5/GNG11/BAK1/TRADD/CALM1/LIMK1/NFATC1/MAP2K3/CCR5/CUL1/APOBEC3F	7.36715043070966
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	30/981	83/9376	3.4545521535684	NFKBIA/CCL4L2/PYCARD/CASP1/CCL4/IRF7/IL1B/NLRP3/IFI16/SAMHD1/CXCL10/MEFV/ADAR/POLR3GL/MLKL/POLR1D/AIM2/DNASE2/CCL5/IL18/CASP8/PCBP1/NFKB1/ZBP1/RELA/ZDHHC1/IKBKE/GSDMD/CASP7/IL6	7.67791205992402
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	37/981	119/9376	2.97168898140296	NFKBIA/FOS/JUN/JUNB/CEBPB/TNFAIP3/IRF1/SOCS3/TNF/TNFRSF1B/IL1B/CXCL2/BIRC3/CXCL10/MAP3K8/ICAM1/CXCL3/MLKL/IL15/ADAM17/PTGS2/BCL3/CCL5/NOD2/CASP8/PIK3CD/FAS/CASP10/NFKB1/RELA/TRADD/CCL20/MAP2K3/CASP7/TRAF1/IL6/CXCL1	7.39923038569754
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	34/981	105/9376	3.09484005630795	NFKBIA/GADD45B/BCL2A1/CCL4L2/TNFAIP3/TNFSF13B/CCL4/CD14/TNF/CXCL8/IL1B/LYN/SYK/MYD88/CXCL2/BIRC3/BTK/ICAM1/TLR4/CXCL3/CSNK2B/RELB/LTB/PTGS2/CD40/NFKB2/IRAK1/NFKB1/RELA/TRADD/TNFSF14/TICAM1/TRAF1/CXCL1	7.37890672019422
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	31/981	91/9376	3.25588376964524	NFKBIA/FOS/JUN/GRB2/PTPN6/LILRB2/LYN/LILRB1/SYK/LILRB4/RAC1/DAPP1/RAC2/LILRA2/LILRA5/PIK3AP1/LILRB3/BTK/IFITM1/FCGR2B/VAV1/NFKBIE/LILRA1/PIK3CD/CD72/NFKB1/RELA/VAV2/NFATC1/CD79B/LILRA4	7.39190290104856
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	44/981	168/9376	2.5031794573079	FTH1/PYCARD/TNFAIP3/TNFSF10/STAT1/IFNGR2/CASP1/FTL/TNF/CYBB/IL1B/BID/NLRP3/STAT2/JAK1/JAK2/STAT3/GLUL/BIRC3/CHMP1B/IFNGR1/CAPN2/TLR4/CHMP5/EIF2AK2/MLKL/CAMK2D/STAT5A/CHMP2A/CHMP2B/CHMP4A/CASP8/TYK2/FAS/CHMP3/BAX/IRF9/RBCK1/ZBP1/CHMP4B/TNFRSF10A/TRADD/IL1A/TICAM1	6.72036109856358
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/981	82/9376	3.26356878247682	HLA-A/HLA-C/HLA-B/B2M/HLA-F/HLA-E/HLA-DPB1/PSME2/HLA-DRA/HLA-DPA1/CTSS/IFI30/HLA-DQA2/TNF/HLA-DMA/TAP1/HSPA1A/CD74/TAPBP/HLA-DQA1/HLA-DMB/PSME1/HLA-DRB1/TAP2/HSPA6/HLA-DQB1/HLA-DRB5/HLA-DOA	7.03734884235801
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	31/981	98/9376	3.02332064324201	ARPC3/NCF1/VASP/WAS/FCGR1A/FCGR2A/LYN/HCK/PTPRC/SYK/ARPC1B/CFL1/FCGR3A/ARPC4/RAC1/RAC2/MARCKS/ACTR3/ACTR2/PRKCD/MARCKSL1/CDC42/FCGR2B/PAK1/VAV1/ARF6/SPHK1/PIK3CD/ARPC5/VAV2/LIMK1	6.88272405380443
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	31/981	100/9376	2.96285423037717	HLA-DPB1/HLA-DRA/HLA-DPA1/CD37/HLA-DQA2/CD14/TNF/FCGR1A/HLA-DMA/IL1B/CD44/HLA-DQA1/HLA-DMB/ITGA4/HLA-DRB1/CD1D/CD9/ITGAM/ITGA5/CD38/IL6R/HLA-DQB1/HLA-DRB5/ANPEP/HLA-DOA/IL3RA/FLT3LG/IL1A/CD2/FLT3/IL6	6.74555161876929
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	54/981	238/9376	2.16852979724	NFKBIA/FOS/ISG15/JUN/MX1/STAT1/CASP1/MX2/OAS1/OAS2/RPS9/TNF/CXCL8/FCGR2A/CYBB/IL1B/CFD/NLRP3/C5AR1/STAT2/SYK/JAK1/TLR2/IFIH1/STAT3/MYD88/RPL36A/CXCL10/OAS3/RPL28/TLR4/ADAR/EIF2AK2/IL6R/RPS27L/ADAM17/RPS26/HBEGF/IRAK1/RPL19/PIK3CD/TYK2/RPL17/RPL36AL/IRF9/NFKB1/RELA/RPS10/RPL29/IKBKE/RPL26/RPL9/RPS3A/IL6	6.24183788152745
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/981	93/9376	2.98032510166278	NFKBIA/FOS/JUN/HLA-DPB1/STAT1/HLA-DRA/HLA-DPA1/IFNGR2/HLA-DQA2/HLA-DMA/HLA-DQA1/HLA-DMB/JAK1/JAK2/HLA-DRB1/IFNGR1/NOTCH1/HLA-DQB1/HLA-DRB5/STAT5A/RUNX3/NFKBIE/IL2RG/HLA-DOA/TYK2/NFKB1/RELA/IL12RB1/NFATC1	6.56060035507271
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	33/981	116/9376	2.71897078983444	CYBA/NCF2/CXCR4/NCF1/MSN/ITGB2/GNAI2/VASP/RHOA/CYBB/PECAM1/ACTB/RAP1A/RAC1/RAP1B/RAC2/ITGA4/NCF4/MYL12A/RASSF5/ITGAM/ICAM1/ITGAL/PTK2B/CDC42/GNAI3/VAV1/ACTG1/ROCK1/SIPA1/PIK3CD/VAV2/RHOH	6.36798145233369
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/981	100/9376	2.86727828746177	CCL3L3/CCL3/CXCR4/CCL4L2/TNFSF10/CCL4/TNF/TNFRSF1B/CXCL8/IL10RA/TNFRSF14/CXCL2/CCR2/CXCL10/CXCL3/IL6R/IL2RG/CCL5/PPBP/IL18/PF4/CXCL9/TNFRSF10A/CXCL11/TNFSF14/CCL20/CCR5/TNFRSF10D/IL6/CXCL1	6.41709500366729
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	62/981	298/9376	1.98849277206521	CCL3L3/CCL3/CXCR4/CCL4L2/TNFSF10/TNFSF13B/IFNGR2/CCL4/TNF/TNFRSF1B/CXCL8/IL1B/TGFB1/IL10RA/TNFRSF14/CXCL16/CXCL2/CCR2/CXCL10/IL13RA1/TNFSF12/IFNGR1/IL1RN/CXCL3/IL27RA/CSH1/RELT/IL6R/OSM/CSF2RB/IL15/LTB/CD40/IL2RG/CCL5/PPBP/INHBA/IL18/FAS/IL3RA/PF4/IL1RAP/EBI3/CXCL9/TNFRSF10A/IL15RA/CXCL11/TNFSF14/IL12RB1/IL27/CCL20/IL1A/CCR5/IL32/TNFSF8/ACVR1B/GH2/TNFRSF10D/IL21R/IL6/CXCL1/TNFSF13	5.92783808348924
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	36/981	137/9376	2.51148463135338	NFKBIA/FOS/JUN/GADD45B/BCL2A1/TNFSF10/CTSS/MCL1/CTSH/TNF/TUBA1A/BID/ACTB/CTSD/BIRC3/CAPN2/PARP4/CSF2RB/ACTG1/TUBA4A/ITPR1/CASP8/PIK3CD/FAS/BAX/CASP10/IL3RA/NFKB1/RELA/TNFRSF10A/BAK1/TRADD/BBC3/CASP7/ERN1/TRAF1	6.09202009672744
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	50/981	224/9376	2.13339158293287	NFKBIA/HLA-A/HLA-C/HLA-B/FOS/B2M/JUN/HLA-F/HLA-E/HLA-DPB1/SPI1/HLA-DRA/TSPO/HLA-DPA1/HLA-DQA2/ITGB2/ZFP36/TNF/HLA-DMA/TGFB1/HLA-DQA1/HLA-DMB/JAK1/HLA-DRB1/CDKN1A/TLN1/ICAM1/ITGAL/EGR1/RELB/HLA-DQB1/HLA-DRB5/IL15/STAT5A/CD40/IL2RG/MAP3K3/NFKB2/HLA-DOA/POLB/PIK3CD/BAX/NFKB1/RELA/ANAPC16/IL15RA/CDC26/MAD1L1/NFATC1/IL6	5.86888741209964
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/981	110/9376	2.69350384579742	TIMP1/IFNGR2/ALDOA/CYBB/LDHA/VEGFA/HMOX1/PGK1/STAT3/CDKN1A/HK2/EIF4EBP1/IFNGR1/GAPDH/PFKFB3/TLR4/IL6R/CAMK2D/HK1/ENO1/HK3/EIF4E2/PIK3CD/NFKB1/RELA/PFKP/CDKN1B/ALDOC/EGLN2/ENO2/IL6	6.10725668445395
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	35/981	133/9376	2.51515639251033	HLA-A/HLA-C/HLA-B/CD48/HLA-E/TYROBP/TNFSF10/IFNGR2/ITGB2/GRB2/FCER1G/TNF/HCST/PTPN6/BID/LAT2/SYK/FCGR3A/RAC1/RAC2/ICAM2/IFNGR1/ICAM1/ITGAL/FYN/PTK2B/PAK1/VAV1/PIK3CD/FAS/MICA/MICB/TNFRSF10A/VAV2/NFATC1	6.01570592880671
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	20/981	54/9376	3.53984973760713	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DMA/CD86/HLA-DQA1/HLA-DMB/HLA-DRB1/HLA-DQB1/HLA-DRB5/CD40/HLA-DOA/FAS/CD80	6.39823439241789
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	39/981	160/9376	2.32966360856269	HLA-A/HLA-C/HLA-B/HLA-F/HLA-E/HLA-DPB1/HLA-DRA/VCAN/HLA-DPA1/HLA-DQA2/ITGB2/HLA-DMA/CD86/PECAM1/JAML/PTPRC/HLA-DQA1/HLA-DMB/ICAM3/SELL/ICAM2/ITGA4/HLA-DRB1/ITGAM/SELPLG/ICAM1/ITGAL/CD58/HLA-DQB1/SPN/HLA-DRB5/CD40/HLA-DOA/NTNG2/ITGB7/CD80/CD2/ICOSLG/PDCD1LG2	5.7988294078215
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	52/981	250/9376	1.98797961264016	HLA-A/HLA-C/HLA-B/HLA-F/CXCR4/ARPC3/HLA-E/SMAP2/RHOA/HSPA1A/ARRB2/ARPC1B/ARPC4/WIPF1/SH3KBP1/CHMP1B/CAPZA2/CYTH1/ACTR3/RAB8A/SNX2/HSPA6/RAB7A/ACTR2/CHMP5/CDC42/CHMP2A/ARF6/RAB5C/CAPZB/CHMP2B/VPS28/RUFY1/IL2RG/CHMP4A/ARFGAP3/PML/RAB10/ACAP1/SH3GLB1/CHMP3/ARF1/ARPC5/SNF8/CHMP4B/IGF2R/SRC/SMAP1/CCR5/AGAP3/VTA1/AGAP2	5.41237085321929
Human Diseases	Immune disease	hsa05310	Asthma	14/981	32/9376	4.18144750254842	HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/FCER1G/TNF/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DRB1/HLA-DQB1/HLA-DRB5/CD40/HLA-DOA	6.16230411356058
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/981	71/9376	2.9615080903361	NFKBIA/JUN/CXCL8/LYN/ATP6V1F/RAC1/CSK/CXCL2/ATP6V1G1/ATP6V0D1/TCIRG1/CXCL3/ATP6V0E1/CDC42/PAK1/ADAM17/CCL5/HBEGF/NFKB1/RELA/SRC/CXCL1	5.67114669150868
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	27/981	99/9376	2.60661662496525	HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/ITGB2/FCGR1A/HLA-DMA/FCGR2A/CFD/FPR1/C5AR1/HLA-DQA1/FCGR3A/HLA-DMB/PTAFR/HLA-DRB1/ITGAM/SELPLG/FPR3/ICAM1/ITGAL/FCGR2B/HLA-DQB1/HLA-DRB5/DEFB1/HLA-DOA/CAMP	5.49333225387017
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	27/981	101/9376	2.55500045417386	JUN/STAT1/TNF/CXCL8/CYBB/IL1B/TGFB1/VEGFA/RAC1/JAK2/STAT3/ICAM1/EGR1/PRKCD/PLCB2/CDC42/STAT5A/PIK3CD/DIAPH1/BAX/NFKB1/RELA/CDKN1B/IL1A/NFATC1/IL6/PIM1	5.3708625681271
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/981	90/9376	2.65488730320535	NFKBIA/FOS/JUN/STAT1/IFNGR2/PTPN6/JAK1/TLR2/JAK2/STAT3/MYD88/IFNGR1/TLR4/CSNK2B/NFKBIE/MAP3K3/PIK3CD/NFKB1/BATF/BATF3/RELA/BATF2/NFATC1/MAP2K3/TICAM1	5.39243762968486
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	27/981	103/9376	2.50538879486951	CCL3L3/NFKBIA/FOS/JUN/CCL3/IFNGR2/GNAI2/TNF/CXCL8/IL1B/TGFB1/TLR2/MYD88/GNA15/IFNGR1/TLR4/PLCB2/GNAI3/CCL5/IRAK1/CASP8/PIK3CD/FAS/NFKB1/RELA/TICAM1/IL6	5.25130149379397
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	36/981	163/9376	2.11087972083075	NFKBIA/FOS/JUN/STAT1/GRB2/TNF/IRF7/CXCL8/TGFB1/BID/STAT2/JAK1/TLR2/JAK2/IFIH1/STAT3/MYD88/CDKN1A/TLR4/PTK2B/STAT5A/IRAK1/CASP8/PIK3CD/TYK2/FAS/BAX/CASP10/NFKB1/RELA/SRC/NFATC1/MAP2K3/TICAM1/IKBKE/IL6	4.89068956563974
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	41/981	201/9376	1.94955903459258	GADD45B/BCL2A1/CEBPB/SPI1/NFKBIZ/CD14/LMO2/FCGR1A/CXCL8/CD86/LYL1/BIRC3/BCL6/CDKN1A/REL/ITGAM/RARA/ID2/HHEX/MAX/JMJD1C/RXRA/CD40/DDX5/ETV6/PML/BAX/NFKB1/RELA/PBX3/NR4A3/BAK1/ITGB7/CDKN1B/NUPR1/RUNX2/CDK14/CEBPE/TRAF1/FLT3/IL6	4.65186126591527
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	55/981	300/9376	1.75222562011553	FOS/DUSP1/JUN/GADD45B/JUND/GRB2/CD14/TNF/NR4A1/IL1B/TGFB1/FLNA/VEGFA/DUSP2/HSPA1A/ARRB2/RRAS/RAP1A/RAC1/RAP1B/RAC2/MYD88/MAP3K8/STK4/HSPA6/EREG/MAPKAPK3/RASGRP2/TAOK3/CDC42/PAK1/MAX/RELB/MAP3K2/RPS6KA1/MAP3K3/DUSP10/NFKB2/IRAK1/FAS/NFKB1/AREG/IL1RAP/RELA/MAPKAPK2/FLT3LG/LAMTOR3/TRADD/PTPN7/CACNA2D4/IL1A/NFATC1/MAP2K3/CACNA1A/FLT3	4.52659142540085
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	34/981	156/9376	2.08306542251496	NFKBIA/MX1/STAT1/SOCS3/MX2/OAS1/GRB2/OAS2/TNF/IFIT1/IRF7/BID/STAT2/JAK1/STAT3/RSAD2/CXCL10/CDKN1A/OAS3/EIF2AK2/RXRA/YWHAH/CASP8/PIK3CD/TYK2/FAS/BAX/IRF9/NFKB1/RELA/BAK1/TRADD/TICAM1/IKBKE	4.66295604100963
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	24/981	94/9376	2.440236840393	NFKBIA/FOS/FOSB/JUN/CEBPB/TNFAIP3/JUND/S100A8/TNF/CXCL8/IL1B/S100A9/CXCL2/CXCL10/CXCL3/PTGS2/CASP8/NFKB1/RELA/TRADD/CCL20/IKBKE/IL6/CXCL1	4.79718925363214
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/981	50/9376	3.05843017329256	ITGB2/TNF/CXCL8/IL1B/PECAM1/TGFB1/TLR2/MYD88/ICAM1/TLR4/ITGAL/HBA1/CD40/IL18/HBA2/IL6	4.98865220942556
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/981	205/9376	1.91151885830785	NFKBIA/HLA-A/HLA-C/HLA-B/JUN/HLA-F/HLA-E/GRB2/RHOA/IRF7/LYN/SYK/JAK1/RAC1/SP100/STAT3/PKM/CDKN1A/REL/ATP6V0D1/EIF2AK2/CDC42/STAT5A/YWHAH/NFKB2/CASP8/POLB/PIK3CD/BAX/IRF9/NFKB1/RELA/MAPKAPK2/BAK1/SRC/TRADD/CDKN1B/MAD1L1/CCR5/GTF2B/TRAF1	4.51070093306879
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	35/981	168/9376	1.99116547740401	STAT1/IFNGR2/SOCS3/MCL1/GRB2/PTPN6/STAT2/JAK1/IL10RA/JAK2/STAT3/CDKN1A/IL13RA1/IFNGR1/IL27RA/CSH1/IL6R/OSM/CSF2RB/IL15/STAT5A/PTPN2/IL2RG/PIK3CD/TYK2/IRF9/IL3RA/IL15RA/IL12RB1/IL27/CISH/GH2/IL21R/IL6/PIM1	4.4312672610059
Organismal Systems	Immune system	hsa04611	Platelet activation	28/981	126/9376	2.12390984256428	GNAI2/FCER1G/VASP/APBB1IP/RHOA/FCGR2A/LYN/FERMT3/SYK/ACTB/RAP1A/RAP1B/TBXAS1/MYL12A/BTK/TLN1/FYN/RASGRP2/PLCB2/GNAI3/ACTG1/ROCK1/ITPR1/ORAI1/PIK3CD/SRC/PTGIR/P2RX1	4.34165862030674
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/981	70/9376	2.45766710353866	NFKBIA/SOCS3/TNF/TNFRSF1B/JAK2/STAT3/ACSL1/PRKAG2/ACSL4/RXRA/NFKBIE/NFKB1/RELA/ACSL5/TRADD/CPT1A/IRS2/POMC	4.18442357602248
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/981	142/9376	1.95190305953971	FOS/DUSP1/KLF2/CYBA/JUN/NCF2/NCF1/TNF/RHOA/IL1B/PECAM1/VEGFA/HMOX1/ACTB/RAC1/RAC2/MGST1/ICAM1/GSTO1/CALM3/ACTG1/SUMO2/PIK3CD/SUMO3/NFKB1/RELA/SRC/CALM1/IL1A	3.90707503094452
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/981	72/9376	2.38939857288481	NFKBIA/ISG15/TNF/IRF7/CXCL8/IFIH1/CXCL10/TANK/ADAR/AZI2/ZNFX1/CASP8/CASP10/NFKB1/RELA/DHX58/TRADD/IKBKE	4.04546117439151
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	31/981	157/9376	1.88716829960329	CEBPB/CASP1/PTPN6/SGK1/PECAM1/TGFB1/DUSP2/RAC1/JAK2/ALOX5/PTGER4/RAB7A/HAVCR2/CAMK2D/PTGER2/RXRA/ADAM17/PTGS2/RAB5C/SPHK1/SIRPB1/ODC1/SIGLEC10/ELMO1/NR1H2/MAPKAPK2/VPS41/ATP2A3/CPT1A/NFATC1/CASP7	3.83198433938828
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/981	67/9376	2.42506123815175	ALDH2/FBP1/ALDOA/LDHA/PGK1/PKM/HK2/GAPDH/ALDH3B1/HK1/ENO1/TPI1/HK3/AKR1A1/PFKP/ALDOC/ENO2	4.00155882127096
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	17/981	68/9376	2.38939857288481	BCL2A1/SPI1/GRB2/CD14/FCGR1A/STAT3/ITGAM/EIF4EBP1/RARA/STAT5A/PML/PIK3CD/NFKB1/RELA/CEBPE/FLT3/PIM1	3.93063673937414
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/981	120/9376	1.99116547740401	NFKBIA/JUN/ARHGDIB/GRB2/RHOA/RAP1A/RAC1/RAP1B/PRKCD/RIPK2/CDC42/CALM3/CAMK2D/RPS6KA1/NFKBIE/MAP3K3/IRAK1/PIK3CD/BAX/NFKB1/RELA/MAPKAPK2/CALM1/ZNF274/SH2B2	3.73538102846449
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/981	169/9376	1.8097219960311	UBC/GABARAP/DDIT4/ATG3/RRAS/TAX1BP1/CTSD/CALCOCO2/RAB8A/MAP1LC3B/TANK/RAB7A/PRKCD/IGBP1/NRBF2/ITPR1/PIK3CD/RRAGD/SH3GLB1/MTMR14/GABARAPL2/ULK1/BECN1/VPS41/RUBCN/SMCR8/WDR41/IRS2/ERN1/WDR45/TP53INP2/ATG4A	3.63103144034
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/981	157/9376	1.82629190284189	FOS/JUN/SOCS3/TNF/CXCL8/IL1B/TGFB1/BID/RAC1/MT-CO1/PRKAG2/CDC42/IL6R/RXRA/COX7A2L/CASP8/PIK3CD/FAS/NDUFB5/SDHB/BAX/NFKB1/RELA/SDHD/IL1A/IRS2/COX6B1/CASP7/ERN1/IL6	3.56903829055812
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/981	103/9376	2.04142790693071	ITGB2/CD14/TNF/CXCL8/IL1B/TGFB1/TLR2/CXCL2/CD1D/GNA15/ITGAM/TLR4/CXCL3/RAB7A/PLCB2/SERPINB9/RAB5C/PIK3CD/NFKB1/RELA/IL6/CXCL1	3.63285015936233
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/981	31/9376	3.0830949327546	FBP1/ALDOA/TKT/PGLS/G6PD/TALDO1/PRPS2/PFKP/ALDOC/RBKS	3.97109290997558
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/981	42/9376	2.73074122615407	FTH1/SAT1/FTL/CYBB/HMOX1/SAT2/ACSL1/MAP1LC3B/ACSL4/GPX4/PCBP1/ACSL5	3.84266634956013
NA	NA	hsa04517	IgSF CAM signaling	49/981	299/9376	1.56629471667366	CD48/ARPC3/MSN/ITGB2/GRB2/RHOA/PTPN6/CD86/LYN/TUBA1A/JAML/ARPC1B/ARPC4/ACTB/RAP1A/RAC1/ICAM3/DOK2/RAP1B/ICAM2/ITGA4/MYL12A/CSK/MYL6/SLAMF7/ACTR3/ITGAM/ITGA5/ICAM1/MBP/ITGAL/FYN/ACTR2/CDC42/PAK1/DOK1/VAV1/ARF6/ACTG1/CRTAM/TUBA4A/PIK3CD/DYNLL1/ARPC5/IL1RAP/VAV2/SRC/CD80/CD2	3.40186228113476
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/981	195/9376	1.71546564207115	CYBA/NCF2/NCF1/CASP1/ITGB2/FCGR1A/FCGR2A/CYBB/FPR1/C5AR1/SYK/FCGR3A/ACTB/RAC1/RAC2/TLR2/CLEC7A/NCF4/AQP9/ITGAM/SELPLG/FPR3/TLR4/ITGAL/PLCB2/CASP4/ACTG1/SIGLEC9/PIK3CD/NFKB1/RELA/SRC/GSDMD/AZU1/CAMP	3.45120603062363
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/981	37/9376	2.84144695153869	TNF/IL1B/MYD88/ICAM1/PLCB2/HBA1/IL18/HBA2/FAS/APOL1/IL6	3.83636286240233
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/981	115/9376	1.91151885830785	FOS/JUND/GNAI2/NR4A2/RHOA/MAFB/NACA/SGK1/ARRB2/CDKN1A/EGR1/PLCB2/GNAI3/RXRA/HBEGF/ITPR1/VDR/OXSR1/PDE4B/PDE4A/STK39/RUNX2/MMP17	3.36198234043788
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/981	232/9376	1.60666455762944	TMSB4X/CXCR4/ARPC3/MSN/ITGB2/RHOA/BRK1/RRAS/ARPC1B/CFL1/ARPC4/ACTB/RAC1/RAC2/ITGA4/MYL12A/PFN1/ACTR3/ITGAM/ITGA5/ITGAL/ACTR2/CDC42/PAK1/VAV1/SPATA13/ACTG1/PIP4K2A/RGCC/ROCK1/FGD3/PIK3CD/DIAPH1/ARPC5/VAV2/SRC/ITGB7/LIMK1/LPAR2	3.19841120963624
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/981	77/9376	2.11011822020996	GADD45B/STAT1/TGFB1/VEGFA/JAK1/RAC1/RAC2/STAT3/RALB/CDKN1A/CDC42/PIK3CD/BAX/NFKB1/RALA/RELA/BAK1	3.34353798227107
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/981	35/9376	2.73074122615407	FBP1/ALDOA/HK2/PFKFB3/HK1/TPI1/HK3/PFKP/ALDOC/SORD	3.50654378745805
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/981	78/9376	2.08306542251496	ARPC3/RHOA/RHOG/ARPC1B/HCLS1/ARPC4/ACTB/RAC1/ACTR3/ITGA5/ACTR2/CDC42/ACTG1/PIK3CD/ELMO1/ARPC5/SRC	3.28334873530624
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	51/981	333/9376	1.46377570230781	HLA-A/HLA-C/HLA-B/ISG15/HLA-F/HLA-E/MX1/STAT1/IRF1/MX2/GRB2/TNF/ATP6V1F/VEGFA/STAT2/JAK1/OASL/LFNG/ITGA4/PKM/CDKN1A/ATP6V1G1/ATP6V0D1/EIF4EBP1/TCIRG1/ITGA5/PTGER4/ATP6V0E1/NOTCH1/EIF2AK2/CDC42/PTGS2/CASP8/PIK3CD/TYK2/FAS/MFNG/BAX/IRF9/NFKB1/HES4/PPP2R3C/RELA/BAK1/TRADD/ITGB7/CDKN1B/TICAM1/IKBKE/NOTCH4/PPP2R5B	2.94566690045919
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	34/981	204/9376	1.59293238192321	MSN/GRB2/PLAUR/TNF/RHOA/PTPN6/TGFB1/CD44/FLNA/VEGFA/RRAS/HCLS1/ACTB/RAC1/TLR2/HPSE/STAT3/CDKN1A/ITGA5/TLR4/CDC42/CD63/PAK1/CAMK2D/VAV1/ACTG1/DDX5/ROCK1/HBEGF/ITPR1/PIK3CD/FAS/VAV2/SRC	2.92683352889489
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/981	116/9376	1.81264719322296	FBP1/ALDOA/PGK1/TKT/PKM/HK2/PGLS/GAPDH/HK1/G6PD/ENO1/TPI1/SDS/SDSL/HK3/TALDO1/SDHB/PRPS2/PFKP/SDHD/ALDOC/ENO2	3.01047713221076
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/981	212/9376	1.5779047179428	ITGB2/GNAI2/VASP/APBB1IP/RHOA/VEGFA/FPR1/RRAS/ACTB/RAP1A/RAC1/RAP1B/RAC2/RALB/RASSF5/PFN1/TLN1/ITGAM/ITGAL/RASGRP2/PLCB2/CDC42/CALM3/GNAI3/VAV1/ACTG1/SIPA1/PIK3CD/SIPA1L1/RALA/VAV2/SRC/CALM1/MAP2K3/LPAR2	2.90931952678825
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	15/981	69/9376	2.07773788946505	GRB2/FCER1G/TNF/LYN/SYK/RAC1/RAC2/ALOX5/BTK/FYN/VAV1/ALOX5AP/PIK3CD/VAV2/MAP2K3	3.07144421206474
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/981	125/9376	1.75859734964322	GNAI2/FCER1G/TNF/RHOA/BID/RAC1/RAC2/CTSD/S1PR4/SPTLC2/FYN/PLCB2/GNAI3/SPHK1/ROCK1/PIK3CD/BAX/ASAH1/NFKB1/PPP2R3C/RELA/TRADD/PPP2R5B	2.91864839072876
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/981	133/9376	1.72467866914994	KLF2/SOD2/GADD45B/TNFSF10/GRB2/SGK1/TGFB1/GABARAP/PLK3/HOMER3/STAT3/S1PR4/BCL6/CDKN1A/STK4/PRKAG2/CDKN2D/PIK3CD/GABARAPL2/SGK3/CDKN1B/IRS2/IL6/AGAP2	2.87723022391256
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	29/981	170/9376	1.63041314385081	JUN/ARPC3/MSN/VASP/WAS/RHOA/TUBA1A/ARPC1B/HCLS1/ARPC4/ACTB/RAP1A/RAC1/MYL12A/RAB8B/CD1D/MYL6/ACTR3/RAB8A/PRKAG2/ACTR2/CDC42/ACTG1/ROCK1/TUBA4A/YBX3/ARPC5/SRC/WHAMM	2.83546327391204
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/981	105/9376	1.82049415076938	JUN/BNIP3L/UBC/GABARAP/USP15/RRAS/TAX1BP1/CALCOCO2/MAP1LC3B/CITED2/RAB7A/CSNK2B/RAB5C/TOMM7/FKBP8/GABARAPL2/ULK1/RELA/BECN1/SRC	2.89012508843407
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/981	250/9376	1.49098470948012	CTSS/CTSH/LAPTM5/SLC11A1/AP1S2/ATP6V1F/LAMTOR4/BLOC1S1/LITAF/CD68/CTSD/NPC2/PPT1/IDS/PSAP/ATP6V1G1/ATP6V0D1/TCIRG1/ATP6V0E1/RAB7A/CD63/M6PR/LAMTOR2/LAMTOR1/AP3S1/DNASE2/ARL8A/CTSA/SLC2A6/RRAGD/ASAH1/ACP5/AP5B1/BLOC1S2/SLC36A4/LAMTOR3/VPS41/IGF2R/MAN2B1	2.68972284141091
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/981	144/9376	1.65930456450334	NFKBIA/ALDH2/CD14/TNF/CXCL8/IL1B/C5AR1/MYD88/CXCL2/TLR4/PRKAG2/CXCL3/IRAK1/CASP8/FAS/NFKB1/RELA/SCD/TRADD/CPT1A/MAP2K3/TICAM1/IKBKE/IL6/CXCL1	2.72539354052838
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/981	73/9376	1.96388923798752	CXCR4/MX1/BST2/APOBEC3A/MX2/SAMHD1/APOBEC3G/APOBEC3C/CHMP4A/SUPT4H1/CHMP4B/MDFIC/MAP1S/CCR5/APOBEC3F	2.8260955587012
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/981	87/9376	1.8675758960479	FOS/JUN/GADD45B/GRB2/RHOA/TGFB1/RAC1/RAC2/RALB/CDKN1A/EREG/PIK3CD/BAX/AREG/RALA/BAK1/BBC3	2.77902474591295
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/981	75/9376	1.91151885830785	ALDOA/PGK1/TKT/GLUL/PKM/GAPDH/ENO1/TPI1/SDS/SDSL/TALDO1/PRPS2/PFKP/ALDOC/ENO2	2.70920120009186
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/981	157/9376	1.58278631579631	HLA-A/HLA-C/HLA-B/GADD45B/HLA-F/HLA-E/CXCL8/ZFP36L2/TGFB1/RRAS/RASSF5/CDKN1A/EIF4EBP1/CAPN2/CALM3/ITPR1/PIK3CD/NBN/NFKB1/RELA/MAPKAPK2/CALM1/IL1A/NFATC1/MAP2K3/IL6	2.51725409523747
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/981	51/9376	2.06144190601827	ATP6V1F/ACTB/ATP6V1G1/ATP6V0D1/TCIRG1/ATP6V0E1/ERO1A/ACTG1/KCNQ1/ARF1/SEC61B	2.59816476718872
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/981	122/9376	1.6451596731338	NFKBIA/FOS/JUN/GRB2/TNF/RHOA/PTPN6/PTPRC/MAP3K8/FYN/CDC42/PAK1/VAV1/NFKBIE/PIK3CD/NFKB1/PPP2R3C/RELA/VAV2/NFATC1/PPP2R5B	2.45184026335786
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/981	32/9376	2.38939857288481	BID/BIRC3/CASP8/BAX/BECN1/BAK1/BBC3/CASP7	2.69119529214453
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/981	93/9376	1.74708712856094	WAS/RHOA/PTPN6/ACTB/RAP1A/RAC1/RAP1B/RAC2/MYL12A/FYN/CSNK2B/CDC42/ACTG1/ROCK1/SNAI1/HEG1/SRC	2.47501790326838
NA	NA	hsa04518	Integrin signaling	25/981	154/9376	1.55155751486027	ITGB2/TGFB1/FLNA/VEGFA/FERMT3/ACTB/LIMS1/RAC1/ICAM3/RAC2/PARVG/ICAM2/ITGA4/TLN1/ITGAM/ITGA5/ICAM1/ITGAL/CDC42/ACTG1/PARVB/PIK3CD/SRC/ITGB7/ICAM4	2.35911112842953
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/981	33/9376	2.31699255552467	VAMP5/STX11/STX6/STX4/VAMP3/STX8/STX3/VTI1A	2.5906390479242
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	34/981	226/9376	1.43786816775369	NFKBIA/FOS/JUN/GNAI2/RHOA/RRAS/RAP1A/RAC1/RAP1B/RAC2/FFAR2/HCAR3/CALM3/PAK1/GNAI3/CAMK2D/VAV1/PTGER2/CRH/HCAR2/ROCK1/ORAI1/PIK3CD/NFKB1/GABBR1/RELA/VAV2/PDE4B/CALM1/ATP2A3/ATP1B3/PDE4A/NFATC1/POMC	2.27770165882401
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/981	203/9376	1.45953410363407	JUN/GRB2/VASP/RHOA/FLNA/VEGFA/ACTB/RAP1A/RAC1/RAP1B/RAC2/PARVG/ITGA4/MYL12A/BIRC3/TLN1/ZYX/ITGA5/CAPN2/FYN/CDC42/PAK1/VAV1/ACTG1/PARVB/ROCK1/PIK3CD/DIAPH1/VAV2/SRC/ITGB7	2.26266292778425
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/981	47/9376	2.0335307003275	SOCS3/TNF/PKM/HK2/PRKCD/HK1/HK3/PIK3CD/IRS2/CACNA1A	2.42808874386883
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/981	70/9376	1.77498179700015	JUN/GRB2/TGFB1/VEGFA/RAP1A/RAC1/RAP1B/CDKN1A/CDC42/PAK1/PIK3CD/EGLN2/FLCN	2.2246863460685
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	24/981	154/9376	1.48949521426586	FOS/JUN/GNAI2/RHOA/RGS2/ACTB/MYL6/CDKN1A/CAMK1/PRKAG2/CD38/PLCB2/CALM3/GNAI3/CAMK2D/PTGS2/ACTG1/ROCK1/ITPR1/CAMK1D/SRC/CALM1/CACNA2D4/NFATC1	2.09365945740062
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/981	93/9376	1.64431729746912	JUN/GRB2/EGR1/PTK2B/PRKCD/PLCB2/CDC42/CALM3/CAMK2D/MAP3K2/MAP3K3/HBEGF/ITPR1/SRC/CALM1/MAP2K3	2.13455269895135
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/981	71/9376	1.74998205338043	FOS/STAT1/IRF1/SOCS3/GRB2/JAK2/STAT3/STAT5A/PIK3CD/NFKB1/RELA/SRC/CISH	2.16836130407726
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/981	238/9376	1.36537061307703	GRB2/RHOA/VEGFA/RRAS/RAP1A/RAC1/RAP1B/RAC2/RALB/RASSF5/REL/STK4/RASGRP2/GNB2/SHOC2/CDC42/CALM3/PAK1/ARF6/RAB5C/RASA3/PIK3CD/RASAL3/GNGT2/NFKB1/RALA/RELA/GNG5/GNG11/FLT3LG/CALM1/PLA1A/RIN1/FLT3	1.9516696441013
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/981	38/9376	2.01212511400826	TAP1/PTPRC/BTK/TAP2/CD40/IL2RG/ORAI1/ADA	2.13702132709612
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/981	46/9376	1.86996410051855	PSMB9/PSMB8/PSME2/PSMB10/PSME1/PSMF1/PSMB3/PSMD9/PSMA5	2.021851326219
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/981	76/9376	1.63485165513171	GNAI2/ACTB/PLCB2/CALM3/GNAI3/CAMK2D/ACTG1/HRH2/ITPR1/KCNQ1/CALM1/ATP1B3/KCNJ15	1.89953530448423
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/981	77/9376	1.61361981545468	NFKBIA/GADD45B/GRB2/TGFB1/CDKN1A/STAT5A/PIK3CD/BAX/NFKB1/CTBP2/RELA/BAK1/CDKN1B	1.84814655078703
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	29/981	205/9376	1.35204992416897	CYBA/NCF2/NCF1/CYBB/TGFB1/RAC1/RAC2/CTSD/MT-CO1/NCF4/MT-ND1/GAPDH/PDK4/MPC1/PRKCD/PLCB2/MT-ATP6/CAMK2D/COX7A2L/G6PD/MT-ND2/PIK3CD/NDUFB5/SDHB/NFKB1/RELA/SDHD/ATP2A3/COX6B1	1.7421383079048
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/981	86/9376	1.55588744280871	JUN/GRB2/CDKN1A/EIF4EBP1/EREG/PAK1/CAMK2D/STAT5A/NRG1/HBEGF/PIK3CD/AREG/SRC/CDKN1B	1.77026394414106
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/981	28/9376	2.04805591961555	ATP6V1F/ATP6V1G1/ATP6V0D1/TCIRG1/ATP6V0E1/SLC4A1	1.89851446643869
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/981	80/9376	1.55310907237513	GRB2/VEGFA/JAK1/JAK2/STAT3/EIF4EBP1/IL6R/NRG1/EIF4E2/PIK3CD/BAX/SRC/IL6	1.69831212279422
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/981	227/9376	1.30522212791946	NFKBIA/FOS/SOD2/CYBA/JUN/NCF2/NCF1/GRB2/VEGFA/HMOX1/RAC1/MT-CO1/MGST1/MT-ND1/AHR/GSTO1/PRKCD/MT-ATP6/CYP1B1/COX7A2L/MT-ND2/PIK3CD/NDUFB5/SDHB/AKR1A1/NFKB1/RELA/SDHD/SRC/COX6B1/CBR1	1.59129948509627
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/981	130/9376	1.39687916568651	NFKBIA/FOS/JUN/GNAI2/GRB2/TGFB1/VEGFA/ARRB2/GNA15/GNB2/PLCB2/GNAI3/PIK3CD/GNGT2/NFKB1/RELA/GNG5/GNG11/SRC	1.5576246961801
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/981	44/9376	1.7377444166435	TAF10/CCNH/TAF7/TAF12/GTF2B/GTF2F1/GTF2F2/TAF13	1.67669742056311
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/981	37/9376	1.80819351461553	HK2/HK1/NAGK/GALK1/HK3/NANS/UAP1L1	1.68374309263413
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/981	139/9376	1.37519342324306	FOS/JUN/GNAI2/GRB2/HSPA1A/FKBP5/CTSD/RARA/HSPA6/PRKCD/PLCB2/CALM3/GNAI3/HBEGF/ITPR1/PIK3CD/GABBR1/SRC/CALM1/POMC	1.52337539589488
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/981	75/9376	1.52921508664628	BID/BIRC3/CDKN1A/MGST1/GSTO1/ERCC1/CASP8/PIK3CD/FAS/BAX/BAK1/BBC3	1.57292428432084
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/981	60/9376	1.59293238192321	VEGFA/RAC1/RAC2/MAPKAPK3/CDC42/PTGS2/SPHK1/PIK3CD/MAPKAPK2/SRC	1.57498291162708
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	36/981	275/9376	1.25117597998332	CYBA/NCF2/NCF1/TNF/CYBB/IL1B/TUBA1A/HSPA1A/RAC1/RAC2/MT-CO1/NCF4/MT-ND1/HSPA6/FYN/EGR1/PRKCD/NOTCH1/CSNK2B/MT-ATP6/COX7A2L/MT-ND2/CCL5/TUBA4A/ITPR1/PIK3CD/PSMB3/NDUFB5/SDHB/BAX/PSMD9/SDHD/IL1A/PSMA5/COX6B1/IL6	1.44513921711117
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/981	362/9376	1.21450093207405	MCL1/GRB2/NR4A1/SGK1/VEGFA/DDIT4/SYK/JAK1/RAC1/TLR2/JAK2/PIK3AP1/ITGA4/CDKN1A/EIF4EBP1/ITGA5/EREG/TLR4/GNB2/CSH1/IL6R/PKN1/OSM/RXRA/IL2RG/YWHAH/EIF4E2/PIK3CD/GNGT2/IL3RA/NFKB1/AREG/CDC37/PPP2R3C/RELA/GNG5/SGK3/GNG11/FLT3LG/ITGB7/CDKN1B/LPAR2/GH2/FLT3/IL6/PPP2R5B	1.42276929396206
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/981	76/9376	1.5090938355062	PLIN2/UBC/ACSL1/OLR1/GK/ACSL4/RXRA/ACAA1/CYP27A1/ACSL5/SCD/CPT1A	1.52325619067445
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/981	38/9376	1.76060947475723	HK2/HK1/NAGK/GALK1/HK3/RENBP/UAP1L1	1.60596614652752
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/981	93/9376	1.43877763528548	NFKBIA/GADD45B/BIRC3/CDKN1A/MAX/RXRA/PTGS2/PIK3CD/BAX/NFKB1/RELA/BAK1/CDKN1B/TRAF1	1.45362229031729
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/981	143/9376	1.33672647434115	HLA-DPB1/HLA-DRA/HLA-DPA1/HLA-DQA2/TNF/FCGR1A/HLA-DMA/FCGR2A/CD86/HLA-DQA1/FCGR3A/HLA-DMB/HLA-DRB1/TRIM21/HLA-DQB1/HLA-DRB5/CD40/SSB/HLA-DOA/CD80	1.38702297768001
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/981	62/9376	1.5415474663773	LFNG/DTX3L/NOTCH1/NUMB/ADAM17/PSENEN/TLE3/MFNG/CTBP2/NOTCH4	1.46242649937193
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/981	32/9376	1.79204892966361	GABARAP/ATG3/IGBP1/GABARAPL2/BECN1/ATG4A	1.53415901833918
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/981	71/9376	1.48075404516805	SLC16A3/SCO2/LDHA/PKM/HK2/HK1/G6PD/HK3/PIK3CD/PFKP/FLT3	1.38996455131472
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/981	41/9376	1.63178439123841	TYMP/CXCL8/VEGFA/CDKN1A/HBEGF/SRC/UPK3A	1.38584114425646
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/981	122/9376	1.33179592587022	FOS/JUNB/STAT1/GNAI2/SOCS3/GRB2/JAK2/STAT3/PLCB2/CSH1/GNAI3/STAT5A/ITPR1/PIK3CD/MAP2K3/IRS2/GH2	1.26094460665088
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/981	89/9376	1.39605309876416	GNAI2/GABARAP/GLUL/GNB2/GNAI3/GNGT2/GABARAPL2/GABBR1/NSF/GNG5/GNG11/SRC/CACNA1A	1.28327722833564
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/981	57/9376	1.5090938355062	PPT1/HACD4/ACSL1/ACSL4/ACAA1/ACAA2/ACSL5/SCD/CPT1A	1.31783307088927
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/981	73/9376	1.44018544119085	GADD45B/GRB2/STAT3/RASSF5/CDKN1A/STK4/STAT5A/RXRA/PIK3CD/BAX/BAK1	1.29061106953711
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/981	34/9376	1.68663428674222	BHLHE40/PRKAG2/NFIL3/PER1/CSNK1D/CUL1	1.37105477176916
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	28/981	217/9376	1.23323797310184	FOS/JUN/KLF4/GNAI2/GRB2/VEGFA/ARRB2/JAK2/STAT3/BCL6/MGST1/EIF4EBP1/AHR/GSTO1/GNAI3/CYP1B1/STAT5A/RXRA/RPS6KA1/VDR/PIK3CD/NFKB1/RELA/AIP/SRC/IKBKE/CACNA1A/KPNA5	1.18826932960355
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	23/981	174/9376	1.26336016497358	PPP1R15A/HSPA1A/UBE2D1/UBXN1/UBE2D3/HSPA6/CAPN2/FBXO6/HERPUD1/ERO1A/SSR3/OS9/BAX/DNAJA1/STUB1/SEC61B/BAK1/DNAJB12/DNAJA2/CUL1/RNF5/ERN1/DNAJC5B	1.1986527522404
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/981	50/9376	1.52921508664628	ALDH2/SAT1/LAP3/SAT2/P4HA1/ODC1/CNDP2/SMOX	1.28256476489381
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/981	20/9376	1.91151885830785	CYB5R4/NANS/UAP1L1/CYB5R3	1.39490728068503
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/981	99/9376	1.35157899072272	IL1B/PTGER4/PRKCD/PLCB2/CALM3/CAMK2D/PTGER2/ITPR1/PIK3CD/IL1RAP/TRPV2/SRC/CALM1/MAP2K3	1.20211641004401
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/981	142/9376	1.27883303900877	UBE2L6/SOCS3/UBC/UBE2D1/BIRC3/UBE2R2/UBE2D3/UBE2E1/UBE2B/PML/RNF7/STUB1/ANAPC16/CDC26/UBE2E3/UBE2Z/CUL1/UBE2F/UBE2Q2	1.1444669639368
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/981	43/9376	1.55588744280871	ALDH2/ACSL1/ACSL4/ACAA1/ACAA2/ACSL5/CPT1A	1.2488786757218
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/981	59/9376	1.4579381122687	LAP3/GPX1/MGST1/GSTO1/GPX4/G6PD/GSTK1/ODC1/ANPEP	1.20615893753768
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/981	76/9376	1.38333601588068	GADD45B/GRB2/CDKN1A/CAMK1/CALM3/CAMK2D/CAMK1D/PIK3CD/BAX/BAK1/CALM1	1.14697707686468
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/981	69/9376	1.3851585929767	GNAI2/PTGER4/PLCB2/CALM3/GNAI3/PTGER2/ITPR1/ORAI1/KCNMA1/CALM1	1.09766311706131
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/981	61/9376	1.41013686268612	FTH1/FTL/HMOX1/SLC8A1/MT1X/VDR/MT1F/ATP1B3/MT1E	1.09853041197119
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/981	37/9376	1.54988015538474	GADD45B/TPM3/CDKN1A/RXRA/BAX/BAK1	1.14558815019208
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/981	30/9376	1.59293238192321	TNF/IL1B/NFKB1/RELA/IL6	1.11189224154806
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	46/981	388/9376	1.13311684899692	TNF/CYBB/IL1B/TUBA1A/BID/MT-CO1/MT-ND1/GAPDH/CAPN2/PLCB2/CSNK2B/EIF2AK2/CALM3/MT-ATP6/ADAM17/COX7A2L/PTGS2/MT-ND2/PSENEN/NRBF2/TUBA4A/ITPR1/SNCA/FRAT1/CASP8/PIK3CD/FAS/PSMB3/NDUFB5/SDHB/NFKB1/PSMD9/ULK1/RELA/BECN1/FRAT2/SDHD/CALM1/ATP2A3/IL1A/IRS2/PSMA5/COX6B1/CASP7/ERN1/IL6	0.915434238232143
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/981	38/9376	1.5090938355062	NAMPT/BST1/NADK/CD38/SIRT2/NAPRT	1.07491096595892
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/981	15/9376	1.91151885830785	ST3GAL5/ST6GALNAC4/ST3GAL2	1.20770247608551
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/981	480/9376	1.11505266734625	UBE2L6/GPX1/TNF/TNFRSF1B/CYBB/IL1B/UBC/TUBA1A/BID/RAC1/MT-CO1/LRRK2/RAB8A/MT-ND1/MAP1LC3B/CAPN2/TANK/PLCB2/CSNK2B/CALM3/MT-ATP6/CAMK2D/COX7A2L/PTGS2/CHMP2B/MT-ND2/NRBF2/TUBA4A/ITPR1/SNCA/FRAT1/CASP8/FAS/PSMB3/NDUFB5/SDHB/BAX/NFKB1/PSMD9/ULK1/RELA/BECN1/FRAT2/SDHD/BAK1/CALM1/ATP2A3/IL1A/MAP2K3/SMCR8/WDR41/PSMA5/COX6B1/CASP7/ERN1/IL6	0.884564925567105
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/981	140/9376	1.22883355176933	KLF2/GNAI2/RRAS/SLC8A1/MAP1LC3B/PRKAG2/EGR1/GNB2/PLCB2/CALM3/GNAI3/SPHK1/ITPR1/GNGT2/GNG5/BECN1/GNG11/CALM1	0.932505815180298
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/981	184/9376	1.19469928644241	CXCR4/GNAI2/RHOA/RRAS/CFL1/RAC1/RAC2/MYL12A/SEMA4A/FYN/CDC42/PAK1/GNAI3/CAMK2D/SEMA4D/FES/ROCK1/PIK3CD/NTNG2/SRC/LIMK1/RGS3/SEMA6B	0.911754793320297
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/981	97/9376	1.28091469886608	FOS/GNAI2/GNB2/PLCB2/CALM3/GNAI3/CAMK2D/ITPR1/PER1/GNGT2/GNG5/GNG11/CALM1	0.950647555274311
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/981	31/9376	1.5415474663773	ALDH2/DPYD/ALDH3B1/CNDP2/SMOX	1.03237508302243
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/981	115/9376	1.24664273367903	FOS/GNAI2/JAK2/FYN/GNB2/PLCB2/GNAI3/CAMK2D/ITPR1/KCNQ1/PIK3CD/GNGT2/GNG5/GNG11/CACNA1A	0.909699791143739
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/981	48/9376	1.39381583418281	HK2/PLCB2/HK1/HK3/PIK3CD/SLC2A5/ATP1B3	0.935038117365347
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/981	99/9376	1.25503763424253	TNF/TGFB1/TPM3/ACTB/SLC8A1/ITGA4/ITGA5/PRKAG2/ACTG1/ITGB7/ATP2A3/CACNA2D4/IL6	0.872022883595843
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/981	32/9376	1.49337410805301	HK2/HK1/GALK1/HK3/PFKP	0.955640881436501
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/981	109/9376	1.22758091817935	NFKBIA/SOCS3/TNF/STAT3/PRKAG2/PRKCD/RPS6KA1/PIK3CD/NFKB1/NR1H2/RELA/CPT1A/IRS2/IL6	0.816938388564455
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/981	83/9376	1.26666912297508	UBE2D1/UBE2D3/CSNK2B/MAX/PCGF5/PHC2/KDM2B/FBRS/JARID2/RNF2/PCGF1	0.834148939277235
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/981	75/9376	1.27434590553857	GADD45B/BID/CDKN1A/ZNF385A/CASP8/FAS/BAX/CD82/TNFRSF10A/BBC3	0.815406340473485
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/981	110/9376	1.21642109165045	EMP3/TNF/RHOA/TGFB1/SKIL/ID2/ROCK1/INHBA/HAMP/SKI/TGIF1/SMAD7/CUL1/ACVR1B	0.780476030166119
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/981	102/9376	1.21812476264716	RHOA/RAP1A/RAC1/RAP1B/BST1/RAB8A/CD38/PLCB2/ITPR1/KCNQ1/KCNMA1/ATP2A3/ATP1B3	0.757148913502245
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/981	85/9376	1.23686514361096	TYMP/UPP1/CDA/NUDT16/GUK1/CMPK2/APRT/AMPD2/HPRT1/ADA/AK4	0.74987552737432
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/981	138/9376	1.1773848040302	SOCS3/GRB2/FBP1/HK2/EIF4EBP1/PRKAG2/RHOQ/CALM3/FLOT1/HK1/HK3/EIF4E2/PIK3CD/CALM1/IRS2/PRKAR2B/SH2B2	0.717590645165553
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/981	18/9376	1.59293238192321	ACSL1/ACSL4/ACSL5	0.860715636832628
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/981	149/9376	1.15460870636045	GRB2/FCER1G/RHOA/CXCL8/RRAS/SYK/RALB/CYTH1/AGPAT2/FYN/PTK2B/PLCB2/ARF6/SPHK1/PIK3CD/ARF1/RALA/LPAR2	0.650289305722112
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/981	158/9376	1.14933095910915	GRB2/TNF/RHOA/SGK1/ATP6V1F/DDIT4/LAMTOR4/ATP6V1G1/EIF4EBP1/LAMTOR2/LAMTOR1/RPS6KA1/EIF4E2/PIK3CD/RRAGD/ULK1/LAMTOR3/PRR5L/FLCN	0.647097672420451
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/981	44/9376	1.30330831248262	ARHGDIB/RAB5C/STX4/DYNC1LI1/DYNLL1/NSF	0.689339361575563
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/981	133/9376	1.14978577943329	FOS/GNAI2/ARRB2/GNB2/PLCB2/CALM3/GNAI3/CAMK2D/ITPR1/GNGT2/PPP2R3C/GNG5/GNG11/CALM1/CACNA1A/PPP2R5B	0.594702438535005
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/981	98/9376	1.17031766835174	NR4A2/NR4A1/CAMK1/PLCB2/CALM3/CAMK2D/ITPR1/CAMK1D/ORAI1/CALM1/ATP1B3/POMC	0.579369126029436
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/981	91/9376	1.15531359568057	GNAI2/ARRB2/GNB2/GNAI3/GNGT2/GABBR1/GNG5/GNG11/PDE4B/PDE4A/CACNA1A	0.508919401758017
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/981	12/9376	1.59293238192321	ASGR1/FCGR2B	0.702546187529758
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/981	93/9376	1.13046814201002	LYZ/CST3/BST1/CD38/PLCB2/CALM3/ITPR1/KCNMA1/CALM1/ATP1B3/CAMP	0.43222667736621
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/981	122/9376	1.09677311542254	FBP1/RAB8A/EIF4EBP1/PFKFB3/PRKAG2/RAB10/PIK3CD/PPP2R3C/ULK1/PFKP/SCD/CPT1A/IRS2/PPP2R5B	0.367772864120636
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/981	67/9376	1.141205288542	RAP1A/RAP1B/PLCB2/CALM3/CAMK2D/RPS6KA1/ITPR1/CALM1	0.396503148670429
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/981	49/9376	1.17031766835174	FOSB/JUN/GNAI2/GNAI3/NFKB1/RELA	0.408598291416981
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/981	22/9376	1.30330831248262	ALDH2/ALDH3B1/CNDP2	0.486862990147857
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/981	368/9376	1.03886894473253	CASP1/GPX1/NUP214/TNF/TNFRSF1B/TUBA1A/BID/ACTB/RAC1/MT-CO1/PFN1/RAB8A/CHCHD10/MT-ND1/MAP1LC3B/TANK/MT-ATP6/NRG1/COX7A2L/ACTG1/CHMP2B/MT-ND2/NRBF2/TUBA4A/PSMB3/NDUFB5/SDHB/BAX/ANG/PSMD9/ULK1/SRSF3/BECN1/SDHD/MAP2K3/SMCR8/WDR41/PSMA5/COX6B1/ERN1	0.260029285237301
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/981	78/9376	1.10279934133145	BTG1/PABPC1/NUDT16/ENO1/LSM6/TOB1/PFKP/PATL1/ENO2	0.311639611360848
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/981	14/9376	1.36537061307703	ST3GAL2/CHST2	0.467652332724038
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/981	60/9376	1.11505266734625	GNAI2/LYN/PLCB2/GNAI3/CRH/ITPR1/CACNA1A	0.30560986468592
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/981	107/9376	1.07187973363057	FBP1/LDHA/PKM/PRKAG2/PLCB2/CALM3/CAMK2D/ITPR1/PPP4C/PFKP/CALM1/CPT1A	0.255618156524402
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/981	79/9376	1.08883985599814	ATP6V1F/ATP6V1G1/ATP6V0D1/TCIRG1/ATP6V0E1/NAPA/NSF/STX3/CACNA1A	0.27105646349685
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/981	42/9376	1.13780884423086	ALDH2/IL4I1/KYNU/CYP1B1/KMO	0.305969142235344
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/981	89/9376	1.07388699904935	GNAI2/GRB2/TUBA1A/PLCB2/GNAI3/MAP3K2/TUBA4A/ITPR1/CSNK1D/SRC	0.239406038346777
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/981	99/9376	1.06195492128214	FOS/JUN/GRB2/CDKN1A/NOTCH1/HBEGF/PIK3CD/BAX/SRC/CDKN1B/NOTCH4	0.211835830699511
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/981	90/9376	1.06195492128214	SOD2/EIF4EBP1/PRKAG2/EIF4E2/PIK3CD/BAX/NFKB1/ULK1/RELA/IRS2	0.201879637494875
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/981	233/9376	1.02549294973597	VIM/VCAN/TPM3/ACTB/FMNL1/ITGA4/CAPZA2/FHL3/TLN1/ZYX/ITGA5/PDLIM7/SUN2/CAPZB/ACTG1/ENO1/TNNI2/DIAPH1/AMPD2/PDLIM5/TNNT1/ITGB7/ATP1B3/AGRN/ENO2	0.134698724090551
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/981	82/9376	1.0490042515104	TYMP/UPP1/CDA/DPYD/MGST1/GSTO1/CES1/TPMT/HPRT1	0.152352345246616
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/981	44/9376	1.08609026040219	POLD4/PARP4/POLB/POLE4/MPG	0.19566033208179
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/981	16/9376	1.19469928644241	IL4I1/ALDH3B1	0.266438032813776
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/981	46/9376	1.03886894473253	FTH1/FTL/HMOX1/BLVRA/BLVRB	0.0903338740177321
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/981	56/9376	1.02402795980778	ARRB2/SPOP/CSNK1G2/CSNK1D/PTCH2/CUL1	0.0616471134065495
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/981	105/9376	1.00127178292316	TNF/TGFB1/TPM3/ACTB/SLC8A1/ITGA4/ITGA5/ACTG1/ITGB7/ATP2A3/CACNA2D4	0.00447975373111107
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/981	27/9376	1.06195492128214	HACD4/ACAA1/SCD	0.110200839604479
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/981	115/9376	0.997314186943226	DUSP1/GNAI2/ALOX5/GNB2/PLCB2/GNAI3/PTGS2/ITPR1/GNGT2/GNG5/GNG11/CACNA1A	-0.00990616484156537
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/981	28/9376	1.02402795980778	PPT1/HACD4/ACAA2	0.0435257589221042
NA	NA	hsa03272	Virion - Hepatitis viruses	5/981	48/9376	0.995582738702005	CD9/CHMP1B/CD63/CHMP4A/CHMP4B	-0.0104879167607847
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/981	166/9376	0.978789776844381	GNAI2/VASP/RHOA/RGS2/SLC8A1/PLCB2/CALM3/GNAI3/ROCK1/ITPR1/KCNMB1/KCNMA1/CALM1/ATP2A3/ATP1B3/NFATC1/IRS2	-0.0942495441551803
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/981	18/9376	1.06195492128214	TCN2/ZNF143	0.08993533015233
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/981	78/9376	0.980266081183512	PLCB2/ITPK1/TPI1/PIP4K2A/PIK3CD/MTMR14/MTM1/IMPA1	-0.0598240291323261
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/981	98/9376	0.975264723626454	PLCB2/CALM3/ITPK1/PIP4K2A/ITPR1/PIK3CD/MTMR14/CALM1/MTM1/IMPA1	-0.084141918999511
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	24/981	235/9376	0.9760947361572	GRB2/ACTB/MT-CO1/ACSL1/MT-ND1/PRKAG2/MT-ATP6/ACSL4/COA6/COX7A2L/ACTG1/RPS6KA1/MT-ND2/SMARCD3/NDUFB5/KDM3A/SDHB/SLC25A20/ACSL5/SDHD/CPT1A/MAP2K3/COX6B1/COA5	-0.126864586914456
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/981	138/9376	0.969611015083692	ATP6V1F/MT-CO1/ATP6V1G1/ATP6V0D1/MT-ND1/TCIRG1/ATP6V0E1/MT-ATP6/COX7A2L/MT-ND2/NDUFB5/SDHB/SDHD/COX6B1	-0.122935284176359
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/981	59/9376	0.971958741512466	GNAI2/GNAI3/PTGS2/PIK3CD/ABHD5/IRS2	-0.0738576100971006
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/981	59/9376	0.971958741512466	GADD45B/GRB2/CDKN1A/PIK3CD/BAX/BAK1	-0.0738576100971006
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/981	99/9376	0.965413564801944	FOS/JUN/GRB2/WAS/GPCPD1/RAC1/RAC2/EIF4EBP1/PIK3CD/SLC22A4	-0.118257695748655
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/981	29/9376	0.988716650848887	MOB1A/PAK1/RASSF2	-0.0208022684406727
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/981	19/9376	1.00606255700413	HPSE/IDS	0.00904220007890308
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/981	70/9376	0.955759429153925	SULT1A1/MGST1/GSTO1/CYP1B1/PTGS2/GSTK1/CBR1	-0.126998329876284
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	27/981	268/9376	0.962891962207312	DUSP1/UBE2L6/GNAI2/UBC/TUBA1A/MT-CO1/LRRK2/MT-ND1/CALM3/MT-ATP6/GNAI3/CAMK2D/COX7A2L/MT-ND2/TUBA4A/ITPR1/SNCA/PSMB3/NDUFB5/SDHB/BAX/PSMD9/SDHD/CALM1/PSMA5/COX6B1/ERN1	-0.210685024933052
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/981	122/9376	0.940091241790745	STAT1/ACTB/NOTCH1/PLCB2/RXRA/ACTG1/PIK3CD/PFKP/SRC/ATP2A3/ATP1B3/NOTCH4	-0.227674964232858
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/981	62/9376	0.924928479826379	SOD2/HSPA1A/HSPA6/PRKAG2/PIK3CD/IRS2	-0.202727530394445
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/981	31/9376	0.924928479826379	SEC11A/SEC61B/SEC11C	-0.143112047758832
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/981	154/9376	0.93093450891616	GNAI2/TPM3/SLC8A1/PLCB2/CALM3/GNAI3/CAMK2D/KCNQ1/KCNE1/PPP2R3C/CALM1/ATP2A3/CACNA2D4/ATP1B3/PPP2R5B	-0.295405581859608
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/981	144/9376	0.929210556121871	KLF4/GRB2/SKIL/JAK1/JAK2/STAT3/ID2/INHBA/PCGF5/PIK3CD/JARID2/ACVR1B/HESX1/PCGF1	-0.292625143932355
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/981	194/9376	0.936053049171369	MYO1G/TUBA1A/TPM3/MYO1F/ACTB/MYL12A/MYL6/CAPZA2/DYNLT1/CAPZB/ACTG1/TUBA4A/DYNC1LI1/DYNLT3/DYNLL1/TNNI2/KIF13A/TNNT1/MYO15B	-0.307653495145905
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/981	21/9376	0.91024707538469	ALDH2/DPYD	-0.140749270355926
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/981	155/9376	0.924928479826379	GNAI2/NR4A1/RAP1A/RAP1B/CDKN1A/AHR/PLCB2/GNAI3/CAMK2D/CRH/ITPR1/ORAI1/AIP/CDKN1B/POMC	-0.322152747794328
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/981	10/9376	0.955759429153925	PAPSS1	-0.0478468594537517
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/981	116/9376	0.90632359661148	GNAI2/HOMER3/GLUL/GNB2/PLCB2/GNAI3/ITPR1/GNGT2/GNG5/GNG11/CACNA1A	-0.347027187912179
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/981	86/9376	0.889078538747837	ACTB/SLC8A1/ITGA4/ITGA5/ACTG1/ITGB7/ATP2A3/CACNA2D4	-0.353237451261718
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/981	55/9376	0.86887220832175	PSAP/SPTLC2/SPHK1/ASAH1/CERK	-0.333391581893262
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/981	87/9376	0.878859245199011	TPM3/SLC8A1/MT-CO1/COX7A2L/ATP2A3/CACNA2D4/ATP1B3/COX6B1	-0.388038852697603
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/981	45/9376	0.849563937025711	TAP1/TAP2/DEFB1/ABCA7	-0.345783218958753
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/981	23/9376	0.831095155786021	CTSA/ANPEP	-0.277230078452467
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/981	88/9376	0.86887220832175	SERPINA1/ITGB2/PLAUR/CFD/C5AR1/ITGAM/SERPING1/PROC	-0.422459199410775
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/981	254/9376	0.903079775578511	CXCR4/VEGFA/SLC8A1/PTAFR/GNA15/CAMK1/PTK2B/CD38/PLCB2/CALM3/P2RX7/CAMK2D/ORAI2/SPHK1/HRH2/ITPR1/CAMK1D/ORAI1/ORAI3/CALM1/ATP2A3/P2RX1/NFATC1/CACNA1A	-0.535298500840508
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/981	47/9376	0.813412280131	ALDH2/LDHA/PKM/AKR1A1	-0.438353250865707
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/981	69/9376	0.831095155786021	FOS/FOSB/JUN/CALM3/CAMK2D/CALM1	-0.481361758941429
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/981	36/9376	0.796466190961604	HK2/HK1/HK3	-0.418238650128829
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/981	36/9376	0.796466190961604	ST6GALNAC4/GCNT1/ST3GAL2	-0.418238650128829
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/981	36/9376	0.796466190961604	POLD4/POLE4/RNASEH2B	-0.418238650128829
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/981	59/9376	0.809965617927055	TYMP/UPP1/CDA/DPYD/CMPK2	-0.500529792642028
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	13/981	144/9376	0.862838373541737	PLCB2/NRBF2/ITPR1/PIK3CD/PSMB3/PSMD9/ULK1/BECN1/ATP2A3/PSMA5/GTF2B/CACNA1A/ERN1	-0.566990478883332
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/981	48/9376	0.796466190961604	ALDH2/IL4I1/ACAA1/ACAA2	-0.483250933823851
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/981	37/9376	0.774940077692371	IL4I1/GLUL/ASRGL1	-0.468876677134078
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/981	13/9376	0.735199560887634	XRCC4	-0.326582310357276
NA	NA	hsa04081	Hormone signaling	20/981	219/9376	0.872839661327785	GNAI2/RHOA/JAK2/STAT3/GNA15/GNB2/PLCB2/CSH1/GNAI3/STAT5A/CRH/PIK3CD/GNGT2/HAMP/GNG5/GNG11/SRC/IRS2/POMC/GH2	-0.6508889788047
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/981	38/9376	0.754546917753098	SGK1/PIK3CD/ATP1B3	-0.518254575746873
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/981	83/9376	0.806062169165961	SOD2/ACSL1/ACSL4/GSTK1/ACAA1/ACSL5/DHRS4	-0.606643296648404
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/981	148/9376	0.839518417500069	FOS/JUN/GADD45B/GRB2/CDKN1A/NOTCH1/NFKB2/FRAT1/PIK3CD/BAX/FRAT2/BAK1/NOTCH4	-0.672685481848595
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/981	170/9376	0.84331714337111	GADD45B/GRB2/TGFB1/HMOX1/ACTB/CDKN1A/MGST1/GSTO1/ACTG1/FRAT1/SMARCD3/PIK3CD/BAX/FRAT2/BAK1	-0.704725924508928
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/981	149/9376	0.833884065704766	GNAI2/MT-ND1/GNB2/PLCB2/GNAI3/PTGS2/MT-ND2/ITPR1/NDUFB5/GNGT2/GNG5/GNG11/CACNA1A	-0.698689085014319
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/981	128/9376	0.821355759429154	NUDT16/GUK1/APRT/AMPD2/PRPS2/PAPSS1/HPRT1/PDE4B/PDE4A/ADA/AK4	-0.695632533834538
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/981	63/9376	0.758539229487242	ALOX5/TBXAS1/PTGS2/GPX4/CBR1	-0.657327568442303
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/981	63/9376	0.758539229487242	GADD45B/CDKN1A/BAX/BAK1/PTCH2	-0.657327568442303
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/981	28/9376	0.682685306538517	GCH1/CBR1	-0.57480381025009
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/981	15/9376	0.637172952769283	AK4	-0.480721950333298
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/981	75/9376	0.76460754332314	GPX1/ASGR1/ASGR2/PLCB2/ITPR1/ATP1B3	-0.699629547221218
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/981	53/9376	0.721327871059566	SLC8A1/PLCB2/VDR/ATP1B3	-0.695446010010414
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/981	29/9376	0.659144433899258	CALM3/CALM1	-0.628409959717144
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/981	65/9376	0.735199560887634	ALDH2/AGPAT2/GK/AKR1A1/GPAT3	-0.732296582893693
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/981	65/9376	0.735199560887634	NR4A1/PLCB2/ITPR1/ORAI1/POMC	-0.732296582893693
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/981	65/9376	0.735199560887634	ARRB2/PLCB2/ITPR1/PIK3CD/GABBR1	-0.732296582893693
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/981	16/9376	0.597349643221203	ST3GAL2	-0.55101059142116
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/981	54/9376	0.707969947521426	LDHA/IL4I1/SDS/SDSL	-0.735664278764919
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/981	154/9376	0.806809907727339	ALDH2/GCH1/KYNU/NADK/CMPK2/RDH11/PDXK/AKR1A1/NAPRT/KMO/MTHFD2/MTHFD1L/AK4	-0.826308923917436
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/981	30/9376	0.637172952769283	SDHB/SDHD	-0.680388845573079
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/981	134/9376	0.784578635872625	RHOA/MYL6/PRKCD/PLCB2/CALM3/ROCK1/ITPR1/KCNMB1/KCNMA1/CALM1/PTGIR	-0.85855472054194
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/981	17/9376	0.562211428914073	CYP27A1	-0.617566811130616
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/981	17/9376	0.562211428914073	PAPSS1	-0.617566811130616
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/981	17/9376	0.562211428914073	GLUL	-0.617566811130616
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/981	79/9376	0.725893237332095	MGST1/GSTO1/CYP1B1/ALDH3B1/GSTK1/CBR1	-0.836318439224921
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/981	31/9376	0.616618986550919	ALDH2/AKR1A1	-0.730855613149462
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/981	18/9376	0.530977460641069	MAN2B1	-0.680844976527968
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/981	138/9376	0.761837226137186	CALM3/CAMK2D/RPS6KA1/YWHAH/ITPR1/ANAPC16/CALM1/CDC26/MAD1L1/CUL1/PPP2R5B	-0.963461213518271
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/981	34/9376	0.562211428914073	POLR3GL/POLR1D	-0.874165652666722
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/981	73/9376	0.654629745995839	GADD45B/CDKN1A/PIK3CD/BAX/BAK1	-1.01261566420903
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/981	110/9376	0.6950977666574	GNAI2/STK10/GNAI3/RPS6KA1/PIK3CD/ANAPC16/CDC26/MAD1L1	-1.099564200759
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/981	178/9376	0.751720899334547	JUN/RHOA/RAC1/RAC2/PLCB2/CSNK2B/CAMK2D/TLE3/FRAT1/CTBP2/FRAT2/CCDC88C/NFATC1/CUL1	-1.14317640940391
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/981	21/9376	0.455123537692345	CHST15	-0.85446758233925
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/981	36/9376	0.530977460641069	AKR1A1/SORD	-0.963787562706443
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/981	157/9376	0.730516761136758	ITGB2/TGFB1/ACTB/BIRC3/MOB1A/ID2/ACTG1/YWHAH/AREG/CSNK1D/SMAD7/BBC3	-1.1639905883848
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/981	63/9376	0.606831383589793	POLD4/ERCC1/CCNH/POLE4	-1.07032115429736
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/981	37/9376	0.516626718461581	IL4I1/ALDH3B1	-1.00703161957613
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/981	158/9376	0.725893237332095	GADD45B/TGFB1/CDKN1A/CDKN2D/YWHAH/CCNH/ANAPC16/CDC26/CDKN1B/MAD1L1/CUL1/PPP2R5B	-1.18779018882119
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/981	51/9376	0.562211428914073	LPCAT2/PLA2G7/LPCAT1	-1.07160536476291
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/981	101/9376	0.662407525156185	GNAI2/PLCB2/CALM3/GNAI3/CAMK2D/CALM1/POMC	-1.16602074395106
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/981	52/9376	0.551399670665726	ALOX5/CYP1B1/PTGS2	-1.10884264243739
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/981	52/9376	0.551399670665726	TSPO/NPC2/CYP27A1	-1.10884264243739
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/981	23/9376	0.415547577893011	GLUL	-0.959284451470135
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/981	23/9376	0.415547577893011	POLD4	-0.959284451470135
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/981	23/9376	0.415547577893011	ATP1B3	-0.959284451470135
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/981	150/9376	0.700890248046211	GADD45B/GRB2/TGFB1/CDKN1A/RXRA/FRAT1/PIK3CD/BAX/FRAT2/BAK1/CDKN1B	-1.26234850115691
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/981	39/9376	0.490133040591756	MTHFD2/MTHFD1L	-1.09067481615469
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	25/981	308/9376	0.775778757430134	SOD2/GPX1/TUBA1A/MT-CO1/MT-ND1/PLCB2/MT-ATP6/COX7A2L/MT-ND2/NRBF2/TUBA4A/ITPR1/CASP8/PSMB3/NDUFB5/SDHB/BAX/PSMD9/ULK1/BECN1/SDHD/BBC3/PSMA5/COX6B1/ERN1	-1.36774819132897
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/981	68/9376	0.562211428914073	DHRS4L2/ALDH1A1/RDH11/DHRS4	-1.23851274585346
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/981	106/9376	0.63116188717712	NFKBIA/GRB2/CDKN1A/PIK3CD/NFKB1/RELA/CDKN1B	-1.30544520829815
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/981	41/9376	0.466224111782402	SDS/SDSL	-1.17085606729534
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/981	41/9376	0.466224111782402	POLD4/NBN	-1.17085606729534
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/981	26/9376	0.367599780443817	ACAA1	-1.10378038545477
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/981	26/9376	0.367599780443817	HHEX	-1.10378038545477
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/981	26/9376	0.367599780443817	TCN2	-1.10378038545477
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/981	86/9376	0.555674086717398	PLCB2/CAMK2D/KCNMB1/KCNMA1/ATP1B3	-1.41498814896311
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/981	73/9376	0.523703796796671	MGST1/GSTO1/ALDH3B1/GSTK1	-1.39648678650005
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/981	243/9376	0.707969947521426	HSPA1A/HSPA6/SF3B5/SRSF5/SYF2/DDX5/PQBP1/SLU7/ZMAT2/PCBP1/LSM6/CCDC12/SRSF3/BUD31/DHX8/CWC25/CWC15/BCAS2	-1.57664437649796
NA	NA	hsa04082	Neuroactive ligand signaling	14/981	199/9376	0.672393568248992	GNAI2/P2RY13/OGFR/GNB2/PLCB2/GNAI3/HRH2/GNGT2/GABBR1/GNG5/GNG11/P2RX1/POMC/P2RY11	-1.59675536298606
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/981	89/9376	0.536943499524677	CD44/ITGA4/ITGA5/ITGB7/AGRN	-1.50037927830133
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/981	30/9376	0.318586476384641	PIGZ	-1.27781587461346
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/981	103/9376	0.556753065526558	SLC7A7/SLC8A1/KCNQ1/COL8A2/SLC36A4/ATP1B3	-1.54619411081889
NA	NA	hsa04519	Cadherin signaling	32/981	404/9376	0.757037171607069	NFKBIA/ARPC3/VIM/VASP/RHOA/MYO1G/BRK1/RRAS/ARPC1B/MYO1F/ARPC4/ACTB/RAC1/RAC2/MOB1A/ACTR3/LHFPL2/PTK2B/ACTR2/TAOK3/SHOC2/CDC42/VAV1/ACTG1/ROCK1/PSENEN/YWHAH/NFKB1/ARPC5/RELA/VAV2/MAP2K3	-1.70645828566859
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/981	31/9376	0.30830949327546	GLUL	-1.31859917854009
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/981	104/9376	0.551399670665726	GPCPD1/LPCAT2/AGPAT2/LPCAT1/PLA1A/GPAT3	-1.57253144269752
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/981	49/9376	0.390105889450581	LFNG/MFNG	-1.46315819097003
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/981	32/9376	0.298674821610601	LDHA	-1.3584316661742
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/981	66/9376	0.434436104160875	HSD17B11/CYP1B1/SRD5A1	-1.57611751892993
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/981	108/9376	0.530977460641069	NUP214/SUMO2/SUMO3/DDX19B/KPNA5/EEF1A1	-1.67580071167735
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/981	323/9376	0.710161804944093	VIM/MCL1/GRB2/RHOA/CD44/VEGFA/HMOX1/DDIT4/STAT3/MARCKS/CDKN1A/ITGA5/NOTCH1/CYP1B1/PTGS2/ROCK1/PIK3CD/BMF/NFKB1/BAK1/CDKN1B/IRS2/NOTCH4/PIM1	-1.81205096847766
Genetic Information Processing	Translation	hsa03010	Ribosome	15/981	222/9376	0.645783398076976	RPS9/RPL36A/RPL28/RPS27L/RPS26/MRPL41/RPL19/RPL17/RPL36AL/RPS10/MRPL28/RPL29/RPL26/RPL9/RPS3A	-1.82578543108946
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/981	86/9376	0.444539269373918	PLCB2/GABBR1/CACNA1A/PKD2L1	-1.7689050481969
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/981	117/9376	0.490133040591756	MBD2/ACTB/BAZ1A/ACTG1/SMARCD3/TFPT	-1.8970446378231
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/981	41/9376	0.233112055891201	CACNA1A	-1.6821955096057
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/981	43/9376	0.222269634686959	AGPAT2	-1.74727974388695
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/981	370/9376	0.671614734000055	TSPO/FPR1/C5AR1/PTAFR/S1PR4/P2RY13/FPR3/PTGER4/OGFR/CSH1/P2RX7/PTGER2/CRH/HRH2/LTB4R/P2RY8/UTS2/GABBR1/GPR35/PTGIR/P2RX1/POMC/LPAR2/NMB/GH2/P2RY11	-2.20307024727056
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/981	63/9376	0.303415691794897	ALDH2/KMT2E	-1.89630832600748
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/981	44/9376	0.217218052080437	MGAT1	-1.7790557858933
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/981	191/9376	0.550437367575559	FOSB/GNAI2/GRB2/GNB2/CALM3/GNAI3/CRH/GNGT2/GNG5/GNG11/CALM1	-2.14574001635699
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/981	103/9376	0.371168710351039	PABPC1/PPP2R3C/DDX19B/PPP2R5B	-2.19357464459154
NA	NA	hsa04382	Cornified envelope formation	12/981	217/9376	0.528530559900788	S100A4/S100A6/S100A8/S100A9/S100A12/S100A10/S100A11/SPTLC2/PADI2/ABHD5/PPP2R3C/PPP2R5B	-2.40197883759965
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/981	90/9376	0.318586476384641	AQP9/RXRA/ATP1B3	-2.22038075886045
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/981	54/9376	0.176992486880356	ERCC1	-2.0732702796117
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/981	56/9376	0.170671326634629	MGAT1	-2.12775945969878
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/981	183/9376	0.208909164842388	NOP10/CSNK2B/GNL2/RIOK2	-3.69430765356597
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/981	449/9376	0.149004810781235	RGS2/ARRB2/SLC8A1/CALM3/CAMK2D/SLC24A4/CALM1	-6.31694796894485