category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	64/909	222/9376	2.97358744883497	RPS4Y1/RPL23/RPL27A/RPS20/RPS9/RPL5/RPL9/RPS11/RPL13A/RPS6/RPL3/MRPS28/RPL7/RPL6/RPS17/RPS4X/MRPS23/RPL7A/RPS3/RPS16/MRPS31/RPS10/DAP3/MRPS9/RPL15/MRPL9/RPS3A/MRPL44/RPL31/MRPL46/MRPL32/MRPS35/RPL10A/MRPL11/MRPS18A/MRPL45/MRPL18/MRPL3/RPL23A/MRPL13/RPL4/MRPS2/MRPL15/MRPS22/RPS8/MRPL19/MRPS12/RPL26L1/MRPL17/RPL24/RPL26/MRPL39/MRPL34/MRPL43/MRPS11/RPL11/MRPS15/RPL36A/RPL14/RPL17/MRPS18C/RPL8/RPLP0/RPL27	9.75057456191587
Genetic Information Processing	Transcription	hsa03040	Spliceosome	63/909	243/9376	2.67416371266756	HNRNPA1/RBM17/EIF4A3/SRSF5/SRSF9/THOC3/BCAS2/DDX39B/HNRNPM/SF3B2/SRSF4/SNRNP27/LSM6/THOC6/SNW1/RBM8A/RBMX2/BUD31/SNRPA1/SRSF3/HNRNPA3/ZMAT2/ACIN1/HSPA1A/CDC5L/ALYREF/SNRPE/WBP11/PHF5A/CWC25/PRPF6/CRNKL1/PRPF38A/PRPF40A/PPIH/PPIE/SYF2/PRPF38B/SRSF7/PQBP1/RBMX/ISY1/MAGOH/PRPF3/SNRPD1/SF3A3/SF3B6/SNRPB/DHX8/HSPA1B/SNRPF/PUF60/PRPF31/PPIL1/BUD13/CWC15/PRPF4/AQR/SRSF2/SNRPD3/LSM4/FUS/PLRG1	8.66357485833884
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	58/909	248/9376	2.41229284218744	ANXA2/HSP90AB1/JUN/FOS/TUBB6/MYL12A/GAPDH/TUBA1C/MYL12B/TRADD/ARPC2/RAC1/RHOB/RALA/RPS3/RAF1/RHOA/ARPC1A/RRAS/RIPK2/RAB9A/MAPK9/CYTH2/DCTN6/PFN1/DYNLT1/MAP2K3/ACTG1/RIPK1/DYNC1LI1/ARPC3/AHNAK2/M6PR/SNX9/IL18/ARPC5/ARF1/GCC2/ARPC5L/ACTR10/TXN/NFKBIA/STX10/CYCS/DYNC1I2/KLC1/BRK1/DCTN2/CASP7/MAP2K4/CHUK/FBXO22/SKP1/MAPK13/DYNLRB1/TRAF2/TCF7/ROCK2	7.38525648476237
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	54/909	253/9376	2.20154189331977	JUN/MYL12A/BNIP3/PPID/MYL12B/TRADD/ILK/ARPC2/UBC/RAC1/FNBP1/UBE2V1/RHOA/ARPC1A/ATG12/RIPK2/ATG5/UBE2V2/MAPK9/CYTH2/CALCOCO2/PFN1/ACTG1/RIPK1/ARPC3/IL18/ARPC5/ARF1/HK2/ARPC5L/UBE2D2/FNBP1L/CBX3/CAST/TLN2/NFKBIA/UBE2D1/CYCS/IRF3/RRAGC/CRK/RRAGA/BTRC/CAPN2/MAP1LC3B/WIPI2/CHUK/SKP1/MAPK13/TRAF2/BECN1/VDAC1/ROCK2/TIFA	6.34794478734022
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	51/909	238/9376	2.21027817067421	RPS4Y1/RPL23/RPL27A/RPS20/JUN/FOS/RPS9/RPL5/RPL9/RPS11/RPL13A/RPS6/RPL3/RPL7/RPL6/RPS17/RPS4X/RPL7A/RPS3/RPS16/RPS10/RPL15/RPS3A/IFIH1/RPL31/IFNAR1/RPL10A/MAPK9/IRF9/MX1/RPL23A/RPL4/RPS8/RPL26L1/RPL24/RPL26/NFKBIA/OAS3/IRF3/EIF2AK2/RPL11/CHUK/RPL36A/ISG15/RPL14/RPL17/MAPK13/JAK1/RPL8/RPLP0/RPL27	6.19656346019775
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	27/909	108/9376	2.57865786578658	EEF1A1/PHAX/EIF4A3/NUP37/THOC3/UBE2I/DDX39B/THOC6/RBM8A/NXT1/PYM1/SAP18/ACIN1/SNUPN/ALYREF/PNN/RNPS1/MAGOH/TNPO3/SUMO1/NUP58/SRRM1/UPF3A/SUMO2/SENP2/RAN/TPR	5.40641877922377
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	76/909	480/9376	1.63314998166483	UBE2L6/TUBB6/CALM1/SDHB/VDAC2/PPID/MT-CO1/TUBA1C/WNT7A/MT-ATP6/MT-ND5/MT-CYB/UBC/RAC1/PSMD12/SDHC/CSNK2B/RAF1/RAB8A/PSMD4/OPTN/UBE2L3/PSMA2/WNT11/VDAC3/HSD17B10/IFT57/WNT6/CALM3/CSNK1E/MAPK9/DCTN6/NDUFS4/TOMM40/PSMA5/SDHD/ATXN2L/MAP2K3/MT-ND1/EIF2S1/PSMD13/NRAS/CSNK2A1/DAXX/PSMC5/ACTR10/HTRA2/FRAT2/MT-ND6/CYCS/CHMP2B/COX7A2L/SDHA/NRBF2/MT-ND2/MT-CO3/KLC1/MT-CO2/PSMD8/DCTN2/CASP7/CAPN2/MAP1LC3B/WIPI2/PINK1/CSNK2A2/MAPK13/PARK7/SLC25A4/TRAF2/NDUFAB1/BECN1/FZD9/FUS/NEFH/VDAC1	4.66586995455645
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/909	30/9376	4.12585258525853	SDHB/PDHA1/SUCLA2/SDHC/PDHB/IDH3G/SDHD/MDH2/SDHA/DLST/SUCLG2/MDH1	5.61848249155912
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	27/909	117/9376	2.38029956841838	INO80C/SMARCB1/CDK2AP2/MBD2/EPC2/SMARCE1/SMARCC2/GATAD2A/TFPT/BAZ1B/ACTG1/VPS72/RUVBL1/HDAC1/MORF4L2/MTA3/BRD7/GATAD2B/MRGBP/BCL7B/MEAF6/MTA2/SMARCD1/EPC1/SMARCA1/POLE3/RSF1	4.92251491768658
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	61/909	368/9376	1.70976228057588	HNRNPA1/TUBB6/SDHB/NUP37/MT-CO1/TUBA1C/MT-ATP6/MT-ND5/MT-CYB/RAC1/PSMD12/SDHC/RAB8A/PSMD4/OPTN/NXT1/HNRNPA2B1/PSMA2/SRSF3/HNRNPA3/ALYREF/DCTN6/NDUFS4/TOMM40/PFN1/PSMA5/SDHD/ATXN2L/MAP2K3/ACTG1/MT-ND1/EIF2S1/PSMD13/DAXX/SRSF7/PSMC5/ACTR10/MT-ND6/CYCS/CHMP2B/COX7A2L/SDHA/NRBF2/MT-ND2/MT-CO3/KLC1/MT-CO2/PSMD8/DCTN2/NUP58/MAP1LC3B/WIPI2/PINK1/MAPK13/TRAF2/NDUFAB1/BECN1/FUS/NEFH/VDAC1/TPR	4.55119492098576
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/909	116/9376	2.31190015553279	PFKP/GCSH/ALDOA/SDHB/PDHA1/PKM/GAPDH/SUCLA2/TPI1/ENO1/SDHC/MCEE/PDHB/IDH3G/SDHD/MDH2/HK2/GLUD1/PGK1/SDHA/ACAT2/PGLS/ADH5/DLST/SUCLG2/MDH1	4.65829603750172
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/909	103/9376	2.40340927296613	EIF4A3/DAZAP1/DDX39B/WDR33/RBM8A/NXT1/PYM1/SAP18/ACIN1/ALYREF/PNN/PPP2R2D/RNPS1/CSTF2T/MAGOH/SSU72/PPP1CA/SRRM1/SMG7/CPSF6/FIP1L1/UPF3A/PPP2R3C/FUS	4.69240646175296
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/909	105/9376	2.35763004871916	JUN/BNIP3/GABARAP/BNIP3L/UBC/RRAS2/CSNK2B/MTX2/OPTN/RRAS/MAPK9/CALCOCO2/TOMM40/EIF2S1/CCZ1/NRAS/USP15/CSNK2A1/RABGEF1/MAP1LC3B/PINK1/CSNK2A2/TRAF2/BECN1	4.58369382629375
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	44/909	250/9376	1.81537513751375	CLTB/CHMP5/SNX2/ARPC2/SNF8/RAB8A/RHOA/RUFY1/FGFR3/ARPC1A/CHMP2A/EPN2/EHD4/HSPA1A/SNX1/VPS4A/CYTH2/RAB4A/CHMP4B/CAPZB/ARPC3/CAPZA2/ARPC5/ARF1/SMAP2/RAB11FIP1/STAMBP/ARPC5L/CHMP4C/CHMP2B/HSPA1B/ARFGAP2/PARD3/CHMP3/MVB12A/NEDD4L/STAM/SNX6/RAB11B/EEA1/EPS15L1/TSG101/VPS37C/RAB10	4.28144172136912
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	46/909	268/9376	1.77042181830123	UBE2L6/TUBB6/CALM1/SDHB/VDAC2/MT-CO1/TUBA1C/MT-ATP6/MT-ND5/MT-CYB/UBC/PSMD12/SDHC/PSMD4/UBE2L3/PSMA2/VDAC3/CALM3/GNAI3/MAPK9/NDUFS4/PSMA5/SDHD/MT-ND1/EIF2S1/PSMD13/DAXX/PSMC5/TXN/HTRA2/MT-ND6/CYCS/COX7A2L/SDHA/MT-ND2/MT-CO3/GNAI1/KLC1/MT-CO2/PSMD8/PINK1/SLC39A1/PARK7/SLC25A4/NDUFAB1/VDAC1	4.19263696903274
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	60/909	388/9376	1.5950461025484	TUBB6/CALM1/SDHB/VDAC2/GAPDH/PPID/MT-CO1/TUBA1C/WNT7A/MT-ATP6/MT-ND5/MT-CYB/PSMD12/SDHC/CSNK2B/RAF1/PSMD4/PSMA2/WNT11/VDAC3/HSD17B10/WNT6/CALM3/CSNK1E/MAPK9/NDUFS4/PSMA5/SDHD/MT-ND1/EIF2S1/PSMD13/NRAS/CSNK2A1/PSMC5/APH1B/APH1A/FRAT2/MT-ND6/CYCS/COX7A2L/SDHA/NRBF2/MT-ND2/MT-CO3/EIF2AK2/KLC1/MT-CO2/PSMD8/CASP7/CAPN2/WIPI2/CHUK/CSNK2A2/SLC39A1/SLC25A4/TRAF2/NDUFAB1/BECN1/FZD9/VDAC1	3.92227234493145
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/909	308/9376	1.67445315960167	CLTB/TUBB6/SDHB/VDAC2/MT-CO1/TUBA1C/CREB3/MT-ATP6/MT-ND5/MT-CYB/PSMD12/SDHC/TBPL1/PSMD4/PSMA2/POLR2H/POLR2E/VDAC3/IFT57/PPARG/MAPK9/DCTN6/NDUFS4/PSMA5/SDHD/MT-ND1/PSMD13/HDAC1/PSMC5/ACTR10/MT-ND6/CYCS/COX7A2L/SDHA/NRBF2/MT-ND2/MT-CO3/KLC1/MT-CO2/PSMD8/DCTN2/WIPI2/TFAM/POLR2B/POLR2J3/SLC25A4/TRAF2/NDUFAB1/BECN1/VDAC1	3.94343054427929
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/909	200/9376	1.85663366336634	NCL/JUN/CLDN7/FOS/TUBB6/GAPDH/TUBA1C/TRADD/ARPC2/RAC1/RPS3/RHOA/ARPC1A/MAPK9/CYTH2/PAK2/ACTG1/RIPK1/ARPC3/IL18/ARPC5/ARF1/ARHGEF1/ARPC5L/CLDN4/NFKBIA/CYCS/TJP1/BRK1/CASP7/CHUK/MYO1E/MAPK13/TRAF2/CLDN19/ROCK2	4.01223380089748
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/909	137/9376	2.03281058032811	JUN/FOS/TUBA1C/TRADD/CASP6/GADD45B/RAF1/DFFB/CTSV/PARP4/MAPK9/ACTG1/RIPK1/EIF2S1/NRAS/DAXX/DAB2IP/NFKBIA/HTRA2/CYCS/CASP7/CAPN2/GADD45A/CHUK/AIFM1/LMNA/TRAF2	3.98998513997585
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/909	93/9376	2.21820031465512	MYL12A/RAP1B/MYL12B/RAC1/CSNK2B/RHOA/CCM2/RAP1A/ACTG1/PDCD10/ARHGAP29/CSNK2A1/TJP1/ACP1/PARD3/CSNK2A2/TCF7/PTPN1/ROCK2/CTNNA1	3.86828805174178
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/909	37/9376	3.06651205661107	NANS/PMM1/UGP2/PMM2/GNPNAT1/GALK1/CMAS/UAP1/GALE/HK2/GMDS	4.1265909146909
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	39/909	235/9376	1.71178990239449	SDHB/RPS6/SMARCB1/MT-CO1/CREB3/MT-ATP6/MT-ND5/COA6/MT-CYB/SDHC/PRKAG1/SMARCE1/SMARCC2/PPARG/NDUFS4/SDHD/MAP2K3/ACTG1/MT-ND1/GRB2/NRAS/KDM1A/MT-ND6/KDM3B/COX7A2L/SDHA/COA1/MT-ND2/MT-CO3/MT-CO2/SIRT6/FRS2/SMARCD1/MAPK13/COX19/MGLL/COA7/NDUFAB1/NPPB	3.62069297440251
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/909	33/9376	3.12564589792313	STX4/STX3/USE1/STX6/STX8/VAMP3/GOSR1/BET1/YKT6/STX11	4.00781359785494
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/909	170/9376	1.8202290817317	JUN/CLDN7/MYL12A/TUBA1C/MYL12B/ARPC2/RAC1/RAB8A/RHOA/RAB13/PRKAG1/ARPC1A/MYL6/RAP1A/MAPK9/ACTG1/ARPC3/PPP2R2D/ARPC5/ARPC5L/CLDN4/TJP1/YBX3/PARD3/HSPA4/WHAMM/NEDD4L/VASP/CLDN19/ROCK2	3.53611954524788
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/909	227/9376	1.68123948958773	JUN/FOS/SDHB/VDAC2/MT-CO1/HMOX1/MT-ATP6/MT-ND5/MT-CYB/RAC1/SDHC/RAF1/VDAC3/MAPK9/NDUFS4/SDHD/MT-ND1/GRB2/VEGFA/NRAS/NFKBIA/MT-ND6/ACP1/COX7A2L/SDHA/PRKD3/MT-ND2/MT-CO3/MT-CO2/MAP2K4/AKR1A1/CHUK/MAPK13/SLC25A4/NDUFAB1/PTPN1/VDAC1	3.40430709252055
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/909	47/9376	2.63352292676076	LDHA/PDHA1/PKM/GRHPR/PDHB/MDH2/GLO1/ACAT2/HAGH/ADH5/AKR1A1/MDH1	3.67840391880499
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	35/909	216/9376	1.67135232041723	HSP90AB1/JUN/FOS/CALM1/HSPA2/CYP2J2/RAP1B/CASP6/RAC1/VAV2/RHOA/ERO1A/RAP1A/CALM3/HSPA1A/PPARG/MAPK9/MAP2K3/EIF2S1/IL18/NRAS/ARHGEF1/RXRA/NFKBIA/CYCS/IRF3/HSPA1B/CASP7/MAP2K4/HSPA4/CHUK/IRF7/MAPK13/TRAF2/ROCK2	3.27063765873715
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	42/909	275/9376	1.57532553255326	TUBB6/SDHB/VDAC2/MT-CO1/TUBA1C/CREB3/MT-ATP6/MT-ND5/MT-CYB/RAC1/PSMD12/SDHC/CSNK2B/PSMD4/PSMA2/VDAC3/HSPA1A/MAPK9/NDUFS4/PSMA5/SDHD/MT-ND1/EIF2S1/PSMD13/STIP1/CSNK2A1/PSMC5/MT-ND6/CYCS/COX7A2L/SDHA/MT-ND2/MT-CO3/HSPA1B/KLC1/MT-CO2/PSMD8/CSNK2A2/MAPK13/SLC25A4/NDUFAB1/VDAC1	3.17276742387284
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/909	37/9376	2.78773823328279	TPM3/GADD45B/TFG/CCDC6/PPARG/NRAS/RXRA/GADD45A/TCF7/TPR	3.56991111070917
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/909	32/9376	2.9009900990099	IGBP1/GABARAP/ATG12/ATG5/ATG3/ATG4B/WIPI2/ATG10/BECN1	3.52932155964712
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/909	38/9376	2.71437670082798	PMM1/UGP2/PMM2/GNPNAT1/GALK1/UAP1/GALE/GNPDA1/HK2/AMDHD2	3.46955614124701
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/909	136/9376	1.8202290817317	JUN/FOS/EIF3H/TRADD/CSNK2B/IFIH1/IFNAR1/HSPA1A/RAB9A/MAPK9/IRF9/EIF2S1/MX1/CSNK2A1/NFKBIA/OAS3/CYCS/IRF3/HSPA1B/EIF2AK2/CHUK/IRF7/CSNK2A2/JAK1	3.15697710200499
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/909	85/9376	2.06292629262926	ADK/UPP1/DTYMK/UCK2/NT5C/NT5C3B/IMPDH2/NME1/CDA/DCTD/AK1/GMPR2/GUK1/NME6/HDDC2/NT5E/ADSL	3.2254044639243
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	28/909	169/9376	1.70893302347986	BNIP3/IGBP1/GABARAP/DAPK3/UBC/RRAS2/RAF1/RAB8A/OPTN/ATG12/RRAS/ATG5/MAPK9/CALCOCO2/ATG3/EIF2S1/NRAS/EIF2AK4/YKT6/NRBF2/RRAGC/RRAGA/ATG4B/MAP1LC3B/WIPI2/ATG10/WDR45B/BECN1	3.04713915482523
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/909	72/9376	2.14888155482215	TRADD/IFIH1/ATG12/ATG5/MAPK9/PIN1/RIPK1/TRIM25/NFKBIA/IRF3/CHUK/IRF7/ISG15/MAPK13/TRAF2	3.2063391230144
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	30/909	187/9376	1.65475371066518	HSP90AB1/JUN/VDAC2/GABARAP/RHOA/ATG12/IFNAR1/VDAC3/RIPK2/ATG5/TP53BP1/MAPK9/IRF9/RIPK1/GBP2/IL18/TXN/NFKBIA/GBP3/OAS3/IRF3/TRIP6/MAP1LC3B/CHUK/IRF7/MAPK13/TRAF2/JAK1/NLRP7/VDAC1	2.96324421893213
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/909	156/9376	1.71910524385772	CLDN7/TRADD/RAF1/IFIT1/IFNAR1/IRF9/EIF3E/RIPK1/EIF2S1/GRB2/MX1/PPP2R2D/NRAS/RXRA/CLDN4/NFKBIA/YWHAH/OAS3/CYCS/IRF3/EIF2AK2/CHUK/IRF7/TRAF2/JAK1/CLDN19	2.9675093383972
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/909	23/9376	3.1392356626967	GGPS1/PDSS1/IDI1/FNTA/ACAT2/PMVK/FDPS	3.36550221529354
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/909	168/9376	1.65770862800566	HSP90AB1/FTH1/VDAC2/CHMP5/PPID/TRADD/CHMP2A/IFNAR1/VDAC3/STAT4/VPS4A/MAPK9/CHMP4B/IRF9/RIPK1/GLUD1/CHMP4C/PYGL/CHMP2B/EIF2AK2/CAPN2/CHMP3/AIFM1/SLC25A4/TRAF2/JAK1/VDAC1	2.818436954634
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/909	138/9376	1.71910524385772	JUN/FOS/ARPC2/RAC1/VAV2/RHOA/ARPC1A/MAPK9/MAP2K3/ACTG1/ARPC3/IL18/ARPC5/ARHGEF1/ARPC5L/NFKBIA/IRF3/CRK/MAP2K4/CHUK/MAPK13/TRAF2/ROCK2	2.78834058398622
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/909	44/9376	2.34423442344234	TAF7/GTF2F2/GTF2F1/GTF2B/TAF9/TBPL1/MNAT1/TAF3/GTF2A2/TAF12	2.92830821478259
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/909	44/9376	2.34423442344234	APEX1/PARP4/MPG/POLD3/APTX/NTHL1/TDG/POLE3/RFC1/POLB	2.92830821478259
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	25/909	157/9376	1.64245723935451	JUN/FOS/SDHB/MT-CO1/MT-CYB/RAC1/SDHC/PRKAG1/PPARG/MAPK9/NDUFS4/SDHD/EIF2S1/MLX/RXRA/CYCS/COX7A2L/SDHA/MT-CO3/ADIPOR1/MT-CO2/CASP7/MAPK13/TRAF2/NDUFAB1	2.6598365272934
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/909	174/9376	1.6005462615227	HSP90AB1/DNAJA1/DNAJC1/UBXN1/PPP1R15A/RNF5/ERO1A/PDIA6/DNAJA2/HSPA1A/DNAJB11/MAPK9/NGLY1/TXNDC5/EIF2S1/NSFL1C/SEC61A2/UBXN2A/UBE2D2/UBE2D1/RAD23A/HSPA1B/FBXO6/CAPN2/BAG1/SKP1/TRAF2	2.61988831197265
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/909	73/9376	1.97814849978148	SMARCB1/VPS4A/PIN1/CHMP4B/MX1/NELFA/NELFCD/TNPO3/SUPT4H1/CPSF6/MAP1S/SUPT5H/TSG101/RAN	2.74889095754451
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/909	20/9376	3.09438943894389	NANS/UGP2/CYB5R2/CMAS/UAP1/GMDS	3.07206309020791
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	28/909	183/9376	1.57819497796774	GNL3/MPHOSPH10/GAR1/CSNK2B/GTPBP4/RIOK2/SBDS/NXT1/RPP38/GNL3L/GNL2/NOB1/RRP7A/BMS1/UTP6/CSNK2A1/WDR3/FCF1/POP7/EMG1/UTP14A/UTP18/CSNK2A2/IMP4/IMP3/RIOK1/NOP58/RAN	2.58805814904782
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/909	59/9376	2.09789114504671	UPP1/DTYMK/UCK2/NT5C/NT5C3B/NME1/CDA/DCTD/NME6/HDDC2/UMPS/NT5E	2.77172437006561
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/909	67/9376	2.00134640329705	LDHA/PFKP/ALDOA/PDHA1/PKM/GAPDH/TPI1/ENO1/PDHB/HK2/PGK1/ADH5/AKR1A1	2.69508848415631
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/909	10/9376	4.12585258525853	MPST/TST/ETHE1/BPNT1	3.24036711528659
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/909	196/9376	1.52614445117981	JUN/FOS/CALM1/TRADD/UBC/RAC1/RAF1/IFNAR1/CALM3/MAPK9/GNB2/IRF9/ATG3/VEGFA/NRAS/NFKBIA/CYCS/IRF3/EIF2AK2/MAP1LC3B/MAP2K4/CHUK/IRF7/MAPK13/TRAF2/TCF7/GNG10/JAK1/BECN1	2.43901510313918
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/909	34/9376	2.4269721089756	POLR1D/POLR3D/CRCP/POLR2H/POLR2E/POLR3F/POLR2B/POLR2J3	2.73110131667917
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	27/909	180/9376	1.54719471947195	SRSF5/SRSF9/TRADD/SRSF4/SP100/IFIH1/IFNAR1/SRSF3/ALYREF/IRF9/EIF2S1/DAXX/SRSF7/EIF2B1/NFKBIA/OAS3/CYCS/EIF2B3/IRF3/SRPK1/PPP1CA/EIF2AK2/CHUK/IRF7/TRAF2/SRSF2/JAK1	2.42874247980693
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/909	78/9376	1.85134410876985	PFKP/EXOSC8/LSM6/ENO1/EXOSC7/EXOSC3/EXOSC10/TOB2/MPHOSPH6/CNOT4/PNPT1/CNOT10/EDC3/LSM4	2.47377653349513
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/909	78/9376	1.85134410876985	CLTB/ILK/ARPC2/RAC1/RHOA/MAD2L2/ARPC1A/ACTG1/ARPC3/ARHGAP10/ARPC5/ARPC5L/CRK/CTNNA1	2.47377653349513
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/909	56/9376	2.02608832311803	EEF1A1/BNIP3/HSPA1A/EEF1G/IL18/ARF1/NFKBIA/CYCS/HSPA1B/CASP7/CLK4	2.52332739439083
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	22/909	144/9376	1.57584647353624	VDAC2/GTF2B/PSMD12/TBPL1/PSMD4/PSMA2/VDAC3/MAPK9/PSMA5/ATXN2L/PSMD13/PSMC5/SLC1A6/CYCS/NRBF2/PSMD8/ATXN10/WIPI2/SLC25A4/TRAF2/BECN1/VDAC1	2.28161760728801
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/909	203/9376	1.47351878044947	JUN/MYL12A/LAMA3/RAP1B/MYL12B/ILK/RAC1/VAV2/RAF1/RHOA/RAP1A/LAMB3/MAPK9/PPP1R12C/PAK2/ACTG1/GRB2/LAMC2/VEGFA/VEGFB/TLN2/CRK/PDGFA/PPP1CA/CAPN2/ITGA2/VASP/PAK4/ROCK2	2.23476741628953
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/909	205/9376	1.45914298746948	JUN/TRADD/RAC1/GADD45B/PSMD12/PSMD4/SNW1/IFNAR1/MAPK9/IRF9/MAP2K3/RIPK1/PSMD13/HDAC1/PSMC5/NFKBIA/OAS3/CYCS/IRF3/EIF2AK2/PSMD8/GADD45A/MAP2K4/CHUK/IRF7/ISG15/MAPK13/TRAF2/JAK1	2.17780674934898
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	29/909	205/9376	1.45914298746948	SDHB/VDAC2/PDHA1/GAPDH/MT-CO1/MT-ATP6/MT-ND5/MT-CYB/RAC1/MPC1/SDHC/VDAC3/PDHB/MAPK9/NDUFS4/SDHD/MT-ND1/MT-ND6/COX7A2L/SDHA/MT-ND2/MT-CO3/PPP1CA/MT-CO2/PDK3/MAPK13/SLC25A4/NDUFAB1/VDAC1	2.17780674934898
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/909	214/9376	1.44597637333827	JUN/FOS/CALM1/CFL1/TRADD/RAC1/RAF1/CALM3/GNAI3/GNA11/MAPK9/GNB2/PAK2/MAP2K3/RIPK1/NRAS/NFKBIA/CCNB2/CYCS/IRF3/CRK/GNAI1/BTRC/AP1M2/CHUK/SKP1/MAPK13/TRAF2/GNG10/PAK4	2.16235201050012
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/909	138/9376	1.56961783134835	SDHB/MT-CO1/MT-ATP6/MT-ND5/MT-CYB/SDHC/PPA1/NDUFS4/SDHD/ATP6V1D/LHPP/MT-ND1/MT-ND6/CYCS/COX7A2L/SDHA/MT-ND2/MT-CO3/MT-CO2/ATP6V1H/NDUFAB1	2.20870106299083
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/909	31/9376	2.32911033038788	HYI/GCSH/GRHPR/MCEE/MDH2/ACAT2/MDH1	2.42859461393098
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/909	31/9376	2.32911033038788	SRP54/SEC11A/SRP19/SEC61A2/SPCS2/SRPRA/SRP68	2.42859461393098
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/909	157/9376	1.51106066020615	IGFBP3/CALM1/VDAC2/PPID/RRAS2/GADD45B/RAF1/VDAC3/RRAS/CALM3/MAP2K3/NRAS/CCNB2/PPP1CA/HUS1/BTRC/CAPN2/GADD45A/TRAF3IP2/MAPK13/SLC25A4/VDAC1/RAD50	2.11584169095012
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/909	116/9376	1.6005462615227	CLDN7/MYL12A/CD99/RAP1B/MYL12B/RAC1/VAV2/RHOA/RAP1A/GNAI3/ACTG1/CLDN4/GNAI1/MAPK13/VASP/CLDN19/ROCK2/CTNNA1	2.13242010726917
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/909	32/9376	2.25632563256326	BOK/MAPK9/BIRC7/HTRA2/CYCS/CASP7/BECN1	2.33245672518345
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/909	19/9376	2.71437670082798	GCSH/PDHA1/PDHB/DLST/LIPT2	2.45085456906653
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/909	70/9376	1.76822253653937	JUN/RAP1B/RAC1/RAF1/RAP1A/PAK2/GRB2/VEGFA/NRAS/CRK/PRCC/PAK4	2.11376809925315
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/909	78/9376	1.71910524385772	JUN/FOS/CALM1/IRF1/CFL1/RHOA/CALM3/GNAI3/MAPK9/IRF3/GNAI1/CASP7/MAPK13	2.08952603188733
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/909	71/9376	1.74331799377121	LDHA/PFKP/PDHA1/PKM/RAF1/FGFR3/PDHB/SLC16A3/NRAS/HK2/SIRT6/SLC7A5	2.0599108807177
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/909	232/9376	1.37824816964455	MYL12A/GSN/CFL1/MYL12B/RGCC/ARPC2/RRAS2/RAC1/VAV2/RAF1/RHOA/FGFR3/ARPC1A/RRAS/PPP1R12C/PFN1/PAK2/ACTG1/ARPC3/NRAS/ARPC5/ARHGEF1/ARPC5L/CRK/PDGFA/PPP1CA/BRK1/ITGA2/PIP4K2A/PAK4/ROCK2	1.91141732806187
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/909	34/9376	2.12360059535365	PRKAG1/CSNK1E/CSNK1D/BTRC/NFIL3/BHLHE40/SKP1	2.15047445292732
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/909	173/9376	1.4309315324596	TRADD/RAF1/NXT1/IFIH1/IFNAR1/CALCOCO2/IRF9/ACTG1/EIF2S1/MX1/IL18/TRIM25/NFKBIA/OAS3/CYCS/IRF3/EIF2AK2/CHUK/IRF7/SLC25A4/RAB11B/JAK1/FDPS/VDAC1	1.87443081052524
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/909	35/9376	2.06292629262926	PFKP/ALDOA/PMM1/TPI1/PMM2/HK2/GMDS	2.06415965826457
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/909	83/9376	1.61554468699882	POLR1D/POLR3D/POLR2H/POLR2E/POLR3F/RIPK1/IL18/NFKBIA/IRF3/CASP7/CHUK/IRF7/DDX41	1.84554000918616
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	20/909	142/9376	1.45276499480934	UBE2L6/UBE2I/UBC/UBE2O/UBE2L3/CDC26/UBA3/UBE2F/BIRC7/UBE2E3/UBE2D2/ANAPC16/UBE2D1/UBE2E1/PIAS4/BTRC/ANAPC5/SKP1/NEDD4L/UBE2Q1	1.7812500081125
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/909	178/9376	1.39073682649164	JUN/SFRP1/CACYBP/WNT7A/RAC1/CSNK2B/RHOA/CBY1/WNT11/WNT6/CTBP2/CSNK1E/MAPK9/CTNNBIP1/RUVBL1/CSNK2A1/FRAT2/BTRC/CSNK2A2/SKP1/TCF7/FZD9/SENP2/ROCK2	1.72444935174123
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/909	109/9376	1.51407434321414	JUN/FOS/RAC1/IFNAR1/MAPK9/IRF9/MAP2K3/RIPK1/NFKBIA/IRF3/MAP2K4/CHUK/IRF7/MAPK13/JAK1/MAP3K8	1.76877420766068
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/909	205/9376	1.35851243660951	JUN/GSN/PKM/GTF2B/CREB3/TRADD/RAC1/RHOA/RANBP1/TBPL1/SNW1/SP100/DNAJA3/VDAC3/IRF9/GRB2/GTF2A2/NRAS/HDAC1/NFKBIA/YWHAH/IRF3/EIF2AK2/IRF7/TRAF2/JAK1/POLB	1.70049597942657
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/909	93/9376	1.55274022025859	CKS1B/LAMA3/GADD45B/LAMB3/LAMC2/BIRC7/MAX/RXRA/NFKBIA/CYCS/GADD45A/ITGA2/CHUK/TRAF2	1.7551779982496
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/909	119/9376	1.47351878044947	JUN/FOS/IRF1/CEBPB/CREB3/TRADD/MAPK9/MAP2K3/RIPK1/DAB2IP/NFKBIA/CASP7/MAP2K4/CHUK/MAPK13/TRAF2/MAP3K8	1.70324984148693
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/909	38/9376	1.90006369057958	NMRK1/NAPRT/NT5C/SIRT7/QPRT/SIRT6/NT5E	1.82154919840875
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/909	120/9376	1.46123945727906	JUN/CALM1/RAP1B/RAC1/RAF1/RHOA/RAP1A/RIPK2/CALM3/MAPK9/GRB2/NRAS/NFKBIA/CRK/SH2B2/FRS2/MAPK13	1.66612738416484
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/909	46/9376	1.7938489501124	PSMD12/PSMD4/PSMA2/PSMA5/PSMD13/PSMC5/PSMF1/PSMD8	1.76839292474284
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/909	87/9376	1.5412667703552	JUN/FOS/RAC1/GADD45B/RALA/RAF1/RHOA/MAPK9/GRB2/NRAS/CYCS/GADD45A/TCF7	1.66184039123153
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/909	63/9376	1.6372430893883	MNAT1/POLR2H/POLR2E/POLD3/RAD23A/POLR2B/XPC/POLR2J3/POLE3/RFC1	1.66277469904907
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/909	105/9376	1.47351878044947	UBE2I/TRADD/GADD45B/CSNK2B/PLAU/RIPK1/CSNK2A1/TRIM25/NFKBIA/PIAS4/GADD45A/CHUK/CSNK2A2/TRAF2/EDARADD	1.5987161691273
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/909	105/9376	1.47351878044947	JUN/CALM1/IRF1/RRAS2/PLK3/RAF1/RHOA/RRAS/CALM3/MAPK9/IRF9/NRAS/NFKBIA/CHUK/MAPK13	1.5987161691273
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/909	212/9376	1.31365589389128	CALM1/RAP1B/RAC1/RALA/VAV2/RAF1/RHOA/FGFR3/RAP1A/RRAS/CALM3/GNAI3/PFN1/MAP2K3/ACTG1/VEGFA/NRAS/VEGFB/TLN2/PRKD3/CRK/PDGFA/GNAI1/PARD3/MAPK13/VASP/ID1	1.51349727334252
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	19/909	142/9376	1.38012674506887	HSP90AB1/JUN/FOS/CALM1/HMOX1/RAC1/RHOA/CALM3/MAPK9/ACTG1/VEGFA/TXN/SUMO1/PDGFA/PIAS4/MAP2K4/CHUK/MAPK13/SUMO2	1.49547949929927
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/909	90/9376	1.48989121134336	BATF3/JUN/FOS/CSNK2B/RAF1/MAP2K3/NRAS/CSNK2A1/NFKBIA/CHUK/CSNK2A2/MAPK13/JAK1	1.53006317647938
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/909	144/9376	1.36095831805403	KLF4/SKIL/WNT7A/RAF1/FGFR3/WNT11/WNT6/ID4/GRB2/PCGF1/NRAS/PCGF3/ID3/MAPK13/TCF7/JAK1/ID1/FZD9/KAT6A	1.43018823908331
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/909	83/9376	1.49127201876814	CSNK2B/PCGF1/MAX/HDAC1/RYBP/PCGF3/UBE2D2/CBX3/UBE2D1/ASXL1/MTF2/SKP1	1.47294288323863
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/909	42/9376	1.71910524385772	FTH1/VDAC2/HMOX1/VDAC3/ATG5/MAP1LC3B/SAT1	1.53033320834412
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/909	51/9376	1.61798140598374	ERO1A/KDELR1/ACTG1/ATP6V1D/SEC61A2/ARF1/TJP1/ATP6V1H	1.44990275752975
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/909	94/9376	1.42649158532875	HSP90AB1/JUN/FOS/JUND/CEBPB/TRADD/MAPK9/NFKBIA/ANAPC5/TRAF3IP2/CHUK/MAPK13/TRAF2	1.36162153557183
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/909	112/9376	1.38142385667138	LAMA3/LAMB3/GNAI3/HSPA1A/MAPK9/MAP2K3/LAMC2/BIRC7/NFKBIA/CYCS/HSPA1B/GNAI1/CHUK/MAPK13/JAK1	1.33051688746015
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/909	139/9376	1.33570767148657	KRT19/HSP90AB1/JUN/KRT18/FOS/CALM1/CREB3/KRT17/RAF1/CALM3/GNAI3/HSPA1A/KRT15/EBAG9/GRB2/NRAS/HSPA1B/GNAI1	1.30648971126051
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/909	13/9376	2.38029956841838	XRCC6/XRCC4/RAD50	1.63170001143554
Cellular Processes	Cell motility	hsa04814	Motor proteins	24/909	194/9376	1.27603688203872	TPM1/TUBB6/MYL12A/TPM3/TNNI2/TUBA1C/MYL12B/TNNT3/KIF2A/MYL6/DCTN6/DYNLT1/ACTG1/CAPZB/DYNC1LI1/CAPZA2/ACTR10/DYNC1I2/KIF3B/KLC1/DCTN2/KIF13A/MYO1E/DYNLRB1	1.27292300062238
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/909	44/9376	1.64096409640964	STX4/CREB3/DCTN6/DYNC1LI1/DYNC1I2/DCTN2/RAB11B	1.39628951332056
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/909	122/9376	1.35273855254378	JUN/FOS/VAV2/RAF1/RHOA/MAPK9/PAK2/GRB2/PPP2R2D/NRAS/NFKBIA/CHUK/MAPK13/PPP2R3C/PAK4/MAP3K8	1.28490463618389
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/909	204/9376	1.26404797342479	CD63/RPS6/WNT7A/RRAS2/RAC1/VAV2/RAF1/RHOA/WNT11/RRAS/WNT6/PLAU/PPP1R12C/ACTG1/GRB2/VEGFA/NRAS/ARHGEF1/PPP1CA/TWIST2/FRS2/ITGA2/MAPK13/FZD9/ROCK2	1.2493056360275
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/909	133/9376	1.31841154040216	BNIP3/GABARAP/GADD45B/PLK3/RAF1/PRKAG1/ATG12/CSNK1E/MAPK9/PLK2/GRB2/NRAS/HOMER3/CCNB2/GADD45A/CHUK/MAPK13	1.2117441832928
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/909	71/9376	1.45276499480934	JUN/RAC1/MAPK9/ATP6V1D/NFKBIA/TJP1/MAP2K4/CHUK/MAPK13/ATP6V1H	1.25471944313368
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/909	54/9376	1.52809355009575	LDHA/MPST/MTAP/TST/MDH2/SMS/AHCY/MDH1	1.27513449298867
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/909	125/9376	1.32027282728273	ORMDL2/TRADD/RAC1/RAF1/RHOA/GNAI3/MAPK9/PPP2R2D/NRAS/GNAI1/SPTLC1/MAPK13/PPP2R3C/TRAF2/SPTSSA/ROCK2	1.18109154234153
Organismal Systems	Immune system	hsa04611	Platelet activation	16/909	126/9376	1.30979447151064	MYL12A/RAP1B/MYL12B/RHOA/RAP1A/GNAI3/ACTG1/ARHGEF1/TLN2/ORAI1/PPP1CA/GNAI1/ITGA2/MAPK13/VASP/ROCK2	1.14707250330554
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/909	163/9376	1.26559895253329	JUN/FOS/CREB3/RAF1/IFIH1/IFNAR1/VDAC3/STAT4/MAPK9/MAP2K3/GRB2/NRAS/NFKBIA/CYCS/IRF3/MAP2K4/CHUK/IRF7/MAPK13/JAK1	1.12078529557286
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	16/909	128/9376	1.28932893289329	ADK/NT5C/NUDT5/IMPDH2/NME1/AK1/HDDC3/GMPR2/NUDT9/GUK1/NME6/GART/HDDC2/NT5E/ADSL/PDE6D	1.07988060077974
NA	NA	hsa03272	Virion - Hepatitis viruses	7/909	48/9376	1.5042170883755	CD63/CLDN7/VPS4A/CHMP4B/CLDN4/TSG101/CLDN19	1.14748418887653
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/909	138/9376	1.27064300632962	CALM1/RPS6/RAF1/PRKAG1/CALM3/MAPK9/GRB2/EIF4E2/NRAS/HK2/PYGL/CRK/PPP1CA/SH2B2/PTPN1/TRIP10/FLOT1	1.04942202100007
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/909	130/9376	1.26949310315647	JUN/FOS/CREB3/RAF1/GNAI3/MAPK9/GNB2/GRB2/VEGFA/NRAS/VEGFB/NFKBIA/GNAI1/MAP2K4/MAPK13/GNG10	1.01378342589217
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/909	32/9376	1.61166116611661	PFKP/UGP2/GALK1/GALE/HK2	1.13559189071979
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/909	76/9376	1.35718835041399	PLIN2/FABP7/ILK/UBC/SCD5/PPARG/RXRA/SCP2/ANGPTL4/ACADM	1.0243901829984
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/909	41/9376	1.50945826289946	RAD51/BABAM1/POLD3/UIMC1/TOPBP1/RAD50	1.0711398518998
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/909	41/9376	1.50945826289946	DAPK3/RAF1/FGFR3/RASSF1/VEGFA/NRAS	1.0711398518998
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/909	59/9376	1.39859409669781	ILK/GADD45B/RAF1/GRB2/NRAS/GADD45A/TCF7/CTNNA1	1.00628643974954
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/909	77/9376	1.33956252768134	RAD51/RAC1/GADD45B/RALA/RAF1/MAPK9/VEGFA/GADD45A/CHUK/JAK1	0.980279219761357
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/909	77/9376	1.33956252768134	GADD45B/RAF1/CTBP2/GRB2/NRAS/HDAC1/NFKBIA/CRK/GADD45A/CHUK	0.980279219761357
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	26/909	227/9376	1.18141153322381	CALM1/CREB3/TRADD/RAC1/RAF1/RHOA/CALM3/GNAI3/GNA11/GNB2/RIPK1/GRB2/VEGFA/NRAS/ARHGEF1/NFKBIA/CYCS/IRF3/CRK/GNAI1/CHUK/MAPK13/TRAF2/GNG10/JAK1/ROCK2	0.906554271527305
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/909	69/9376	1.3453867125843	RAC1/VAV2/RAF1/MAPK9/MAP2K3/GRB2/NRAS/MAP2K4/MAPK13	0.943470040964214
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/909	17/9376	1.8202290817317	SEPHS2/SEPHS1/TXNRD1	1.10904125167888
NA	NA	hsa04519	Cadherin signaling	44/909	404/9376	1.12337570390702	KRT19/KRT8/KRT7/KRT18/STK3/PKP3/LIMA1/WNT7A/KRT17/ARPC2/RRAS2/RAC1/VAV2/RAF1/RHOA/ARPC1A/WNT11/RRAS/WNT6/KRT15/MAPK9/MAP2K3/ACTG1/ARPC3/NRAS/ARPC5/APH1B/ARPC5L/APH1A/NFKBIA/YWHAH/TJP1/PPP1CA/BRK1/CHUK/MYO1E/MAPK13/VASP/TCF7/FZD9/SAV1/KRT1/ROCK2/CTNNA1	0.830574308954978
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/909	98/9376	1.26301609752812	GSN/CFL1/ARPC2/RAC1/VAV2/RAF1/ARPC1A/ARPC3/ARPC5/ARPC5L/CRK/VASP	0.85757277136275
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/909	89/9376	1.27484209095067	TUBB6/TUBA1C/RAF1/GNAI3/GNA11/GRB2/NRAS/CSNK1D/TJP1/PDGFA/GNAI1	0.853578218706135
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/909	224/9376	1.15118654722615	JUN/FOS/VDAC2/CREB3/RANBP1/TBPL1/CDC26/VDAC3/GPS2/MAPK9/NRAS/TLN2/NFKBIA/ANAPC16/CCNB2/MAP2K4/ANAPC5/CHUK/SLC25A4/JAK1/FDPS/VDAC1/CRTC3/RAN/POLB	0.750381212866349
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/909	157/9376	1.18256921233525	STK3/WNT7A/WNT11/WNT6/CSNK1E/RASSF1/ACTG1/PPP2R2D/CSNK1D/YWHAH/PPP1CA/BTRC/PARD3/TCF7/ID1/FZD9/SAV1/CTNNA1	0.755854600091937
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/909	63/9376	1.30979447151064	KMT2A/KMT2E/KMT5C/ACAT2/SETD2/DLST/SUV39H2/PRDM2	0.808354641597829
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/909	110/9376	1.21900190019002	LDHA/PFKP/ALDOA/RPS6/PDHA1/GAPDH/HMOX1/ENO1/PDHB/EIF4E2/VEGFA/HK2/PGK1	0.757008712062589
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	18/909	158/9376	1.1750845970673	RPS6/WNT7A/RAF1/RHOA/WNT11/MAPKAP1/WNT6/ATP6V1D/GRB2/EIF4E2/NRAS/LAMTOR2/RRAGC/RRAGA/SLC7A5/CHUK/ATP6V1H/FZD9	0.727211825551824
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/909	101/9376	1.22550076789857	CALM1/CREB3/WNT7A/RAF1/WNT11/WNT6/CALM3/GNAI3/NRAS/GNAI1/TCF7/FZD9	0.746542527556524
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/909	46/9376	1.3453867125843	FTH1/HMOX1/HMOX2/ALAD/HCCS/BLVRA	0.769389968643009
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/909	93/9376	1.22001017306032	JUN/CALM1/RAF1/CALM3/GNA11/MAPK9/MAP2K3/GRB2/NRAS/MAP2K4/MAPK13	0.698622971503504
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/909	170/9376	1.15281175176341	SMARCB1/WNT7A/HMOX1/GADD45B/RAF1/SMARCE1/WNT11/SMARCC2/WNT6/ACTG1/GRB2/NRAS/BRD7/FRAT2/GADD45A/SMARCD1/TXNRD1/TCF7/FZD9	0.658792323009731
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/909	122/9376	1.18364623347581	IGFBP3/FOS/CREB3/RAF1/GNAI3/GNA11/MAPK9/MAP2K3/GRB2/NRAS/CRK/GNAI1/MAP2K4/MAPK13	0.668959758180917
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/909	29/9376	1.42270778802018	STK3/CSNK1E/RASSF1/SAV1	0.746974759162939
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	32/909	300/9376	1.10022735606894	JUN/FOS/JUND/STK3/RAP1B/TRADD/RRAS2/RAC1/GADD45B/RAF1/FGFR3/RAP1A/RRAS/HSPA1A/MAPK9/PAK2/MAP2K3/GRB2/MAX/VEGFA/NRAS/DAXX/VEGFB/CRK/PDGFA/HSPA1B/GADD45A/MAP2K4/CHUK/MAPK13/TRAF2/MAP3K8	0.578099319013537
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/909	57/9376	1.26670912705306	SCD5/FADS1/ACAT2/SCP2/MECR/ACAA2/ACADM	0.661749237914406
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/909	48/9376	1.28932893289329	AUH/MCEE/HSD17B10/ACAT2/ACAA2/ACADM	0.658447290926242
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/909	39/9376	1.32238864912132	GCSH/MTHFD1L/MTHFS/GART/AHCY	0.661014774328598
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/909	31/9376	1.33092018879307	PFKP/ALDOA/DERA/PGLS	0.604668378365055
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/909	70/9376	1.17881502435958	TRADD/PRKAG1/MAPK9/RXRA/NFKBIA/ADIPOR1/CHUK/TRAF2	0.49201042169515
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/909	80/9376	1.16039603960396	RPS6/RAF1/FGFR3/GRB2/EIF4E2/VEGFA/NRAS/PDGFA/JAK1	0.472055841975276
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/909	32/9376	1.28932893289329	LDHA/SUCLA2/MCEE/SUCLG2	0.537159473487958
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	15/909	140/9376	1.10513908533711	CALM1/RPS6/RRAS2/RAF1/PRKAG1/RRAS/CALM3/GNAI3/GNB2/NRAS/GNAI1/MAP1LC3B/TFAM/GNG10/BECN1	0.410666285653014
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/909	91/9376	1.13347598496113	JUN/FOS/RAC1/VAV2/RAF1/GRB2/NRAS/NFKBIA/DAPP1/CHUK	0.419213902064554
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/909	23/9376	1.3453867125843	CA2/GLUD1/MDH1	0.543371525916929
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/909	62/9376	1.16455516519394	PRKAG1/ATG5/HSPA1A/NRAS/HDAC1/CLPB/HSPA1B	0.42593374293195
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/909	62/9376	1.16455516519394	SNW1/MAML2/CTBP2/HDAC1/APH1B/APH1A/NUMB	0.42593374293195
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/909	33/9376	1.25025835916925	PDHA1/PDHB/IDH3G/DLST	0.471851335086132
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	34/909	333/9376	1.05314555479572	PKM/IRF1/LAMA3/CREB3/WNT7A/TRADD/RAF1/TBPL1/MAML2/WNT11/IFNAR1/WNT6/LAMB3/IRF9/ATP6V1D/GRB2/LAMC2/MX1/PPP2R2D/VEGFA/NRAS/HDAC1/HES2/IRF3/EIF2AK2/PARD3/ITGA2/CHUK/ISG15/ATP6V1H/PPP2R3C/TCF7/JAK1/FZD9	0.323545673200649
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/909	142/9376	1.089573746107	JUN/FOS/JUND/FHL2/RAC1/IFNAR1/PPARG/MAPK9/IRF9/GRB2/NFKBIA/CHUK/MAPK13/TRAF2/JAK1	0.352397464046348
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/909	63/9376	1.14607016257181	WNT7A/GADD45B/WNT11/WNT6/GADD45A/TCF7/FZD9	0.381144612872208
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/909	103/9376	1.10156258344281	JUN/FOS/GNAI3/GNA11/MAPK9/PPP2R2D/NFKBIA/GNAI1/MAP2K4/CHUK/MAPK13	0.339582281519433
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/909	154/9376	1.07165002214507	PTS/MTHFD1L/RFK/PMM1/NAPRT/UGP2/PMM2/NME1/AK1/QPRT/NME6/AKR1A1/UMPS/ALAD/LIPT2/ADSL	0.293742597123
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/909	144/9376	1.07444077741107	TRADD/PRKAG1/SCD5/MAPK9/MAP2K3/RIPK1/NFKBIA/IRF3/ADIPOR1/MAP2K4/ADH5/CHUK/MAPK13/TCF7/ACADM	0.294949081477053
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/909	15/9376	1.37528419508618	AK1/ACP1	0.476592914628743
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/909	115/9376	1.07630937006744	FOS/JUND/NACA/CREB3/RAF1/RHOA/GNAI3/GNA11/ARHGEF1/RXRA/GNAI1/OXSR1	0.269774344821491
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/909	75/9376	1.10022735606894	PFKP/ALDOA/PKM/GAPDH/TPI1/ENO1/IDH3G/PGK1	0.285532063246713
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/909	238/9376	1.04013090384669	CALM1/RAP1B/RRAS2/RAC1/RALA/RAF1/RHOA/FGFR3/RAP1A/RRAS/CALM3/MAPK9/RASSF1/GNB2/PAK2/GRB2/VEGFA/NRAS/VEGFB/BRAP/PDGFA/CHUK/GNG10/PAK4	0.205468212537092
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/909	86/9376	1.07943817637578	JUN/RAF1/MAPK9/PAK2/GRB2/NRAS/CRK/MAP2K4/PAK4	0.24247861026353
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/909	76/9376	1.08575068033119	CALM1/GADD45B/RAF1/CALM3/GRB2/NRAS/PDGFA/GADD45A	0.245926707897655
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/909	107/9376	1.0603826737814	LDHA/PFKP/PPP4C/CALM1/PDHA1/PKM/CREB3/PRKAG1/PDHB/CALM3/PYGL	0.205821428279935
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/909	36/9376	1.14607016257181	RNASEH2B/POLD3/POLE3/RFC1	0.28770149908779
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/909	67/9376	1.07764806331379	CALM1/RAP1B/RAF1/RAP1A/CALM3/NRAS/PPP1CA	0.208987020440685
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/909	37/9376	1.11509529331312	HBA2/HBA1/HBB/IL18	0.22983228681882
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/909	181/9376	1.02576445489853	CALM1/CEBPB/TRADD/PLK3/RAF1/RHOA/CEBPG/RIPK2/CALM3/MAPK9/IL18/CYCS/RFXANK/MAPK13/ATP6V1H/NFYC/EEA1/JAK1	0.114679866590185
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/909	27/9376	1.14607016257181	SCD5/FADS1/SCP2	0.249036850172985
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/909	17/9376	1.2134860544878	CA2/GLUD1	0.288656969569122
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/909	110/9376	1.03146314631463	HSP90AB1/RAF1/MAD2L2/CDC26/GNAI3/MAPK9/ANAPC16/CCNB2/GNAI1/ANAPC5/MAPK13	0.10875648041597
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/909	69/9376	1.04641188756557	JUN/FOS/CALM1/CREB3/CALM3/HDAC1/PPP1CA	0.12678028385943
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/909	184/9376	1.00904003443823	MYL12A/CFL1/MYL12B/ILK/RAC1/RAF1/RHOA/RHOD/RRAS/GNAI3/SEMA4C/PAK2/NRAS/GNAI1/PARD3/SEMA4D/PAK4/ROCK2	0.0405767060223542
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/909	122/9376	1.01455391440783	PFKP/CREB3/RAB8A/PRKAG1/SCD5/PPARG/RAB2A/PPP2R2D/ADIPOR1/PPP2R3C/RAB11B/RAB10	0.0530148801779436
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/909	133/9376	1.00819706030753	FOS/CALM1/CREB3/CALM3/GNAI3/MAPK9/GNB2/PPP2R2D/PPP1CA/GNAI1/MAPK13/PPP2R3C/GNG10	0.0311946612714163
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/909	18/9376	1.14607016257181	OLAH/MECR	0.203239933749955
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/909	18/9376	1.14607016257181	ZNF143/ABCD4	0.203239933749955
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/909	154/9376	1.004671895761	JUN/FOS/CALM1/RAF1/RHOA/PRKAG1/MYL6/CALM3/GNAI3/PPP1R12C/ACTG1/NRAS/PPP1CA/GNAI1/ROCK2	0.0191533059340422
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/909	71/9376	1.01693549636654	FOS/IRF1/RAF1/MAPK9/GRB2/NRAS/MAPK13	0.0469322867576436
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/909	50/9376	1.03146314631463	P4HA1/LAP3/SMS/CNDP2/SAT1	0.0730873552025157
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/909	82/9376	1.00630550859964	UPP1/UCK2/IMPDH2/NME1/CDA/TPMT/NME6/UMPS	0.018790075034552
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/909	166/9376	0.994181345845428	CALM1/VDAC2/CREB3/RAF1/RHOA/VDAC3/CALM3/GNAI3/GNA11/PPP1CA/GNAI1/SLC25A4/VASP/NPPB/VDAC1/ROCK2	-0.0247827544283344
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/909	93/9376	0.998190141594805	JUN/FOS/MAML2/STAT4/MAPK9/NFKBIA/CHUK/MAPK13/JAK1	-0.00574704632722365
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/909	73/9376	0.989074249890742	GADD45B/RAF1/RASSF1/GRB2/NRAS/RXRA/GADD45A	-0.0307046380855651
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/909	106/9376	0.973078439919464	HSP90AB1/CREB3/RAF1/PLAU/GRB2/NRAS/NFKBIA/PDGFA/CHUK/TCF7	-0.0913305533088072
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/909	20/9376	1.03146314631463	HSD17B7/SQLE	0.0461503332177467
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/909	193/9376	0.961986354075822	RAP1B/RAC1/VAV2/RAF1/RHOA/RAP1A/GNAI3/GNB2/GRB2/NRAS/PF4/NFKBIA/CRK/GNAI1/PARD3/CHUK/GNG10/ROCK2	-0.174835124631768
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/909	43/9376	0.959500601222913	ACAT2/ADH5/ACAA2/ACADM	-0.0872117439125522
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/909	226/9376	0.958439206752534	JUN/FOS/HCAR2/CALM1/RAP1B/CREB3/RRAS2/RAC1/VAV2/RAF1/RHOA/RAP1A/RRAS/CALM3/GNAI3/MAPK9/NFKBIA/ORAI1/PPP1CA/GNAI1/ROCK2	-0.207219346888129
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/909	21/9376	0.982345853632982	CHST15/B4GALT7	-0.0265361109468067
NA	NA	hsa04382	Cornified envelope formation	20/909	217/9376	0.950657277709338	KRT19/KRT8/KRT7/CLDN7/KRT18/S100A16/PKP3/KAZN/LAMA3/KRT17/LAMB3/KRT15/LAMC2/PPP2R2D/CLDN4/TJP1/SPTLC1/PPP2R3C/KRT1/CLDN19	-0.240952670309437
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/909	99/9376	0.937693769376938	JUN/FOS/RAC1/RAF1/MAPK9/GRB2/NRAS/DGKZ/PDGFA	-0.204196407539111
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/909	110/9376	0.937693769376938	TGIF1/SKIL/FST/RHOA/ID4/NCOR1/HDAC1/ID3/SKP1/ID1	-0.21536963540734
NA	NA	hsa04518	Integrin signaling	14/909	154/9376	0.937693769376938	LAMA3/ILK/RAC1/ICAM3/LAMB3/FERMT2/ACTG1/LAMC2/VEGFA/VEGFB/TLN2/LIMS1/PDGFA/ITGA2	-0.255435985254916
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/909	56/9376	0.920949237780921	CSNK1E/CSNK1G2/CSNK1D/BTRC/IQCE	-0.1943993995066
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/909	68/9376	0.910114540865851	RAF1/PIM1/GRB2/NRAS/CHUK/TCF7	-0.243735343677269
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/909	23/9376	0.896924475056201	POLD3/RFC1	-0.162161146427224
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/909	233/9376	0.929644895820054	TPM1/TPM3/TNNI2/FHL2/COL5A1/TNNT3/CSRP1/PDLIM4/TMOD3/ENO1/PDLIM2/EMD/FHL3/ACTG1/CAPZB/CAPZA2/CSRP2/TLN2/ITGA2/NEBL/LMNA	-0.356313281611578
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/909	148/9376	0.906014925816906	JUN/FOS/WNT7A/GADD45B/RAF1/WNT11/WNT6/GRB2/NRAS/FRAT2/GADD45A/TCF7/FZD9	-0.377605884196784
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/909	36/9376	0.85955262192886	UGP2/HK2/PYGL	-0.276626797030854
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/909	82/9376	0.880517320024686	HSP90AB1/HSPA2/HSPA1A/HSPA1B/RFXANK/HSPA4/NFYC	-0.356051932463233
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/909	149/9376	0.899934288730887	MT-ND5/GNAI3/MAPK9/GNB2/NDUFS4/MT-ND1/MT-ND6/MT-ND2/GNAI1/MAPK13/MGLL/NDUFAB1/GNG10	-0.40341399508651
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/909	138/9376	0.896924475056201	CALM1/MAD2L2/CDC26/CALM3/YWHAH/ANAPC16/CCNB2/PPP1CA/BTRC/ANAPC5/SKP1/MAPK13	-0.399676781488391
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/909	60/9376	0.85955262192886	RAC1/RAF1/VEGFA/NRAS/MAPK13	-0.357583376747354
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/909	60/9376	0.85955262192886	RAF1/GNAI3/GNA11/NRAS/GNAI1	-0.357583376747354
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/909	150/9376	0.893934726806014	WNT7A/GADD45B/RAF1/WNT11/WNT6/GRB2/NRAS/RXRA/FRAT2/GADD45A/TCF7/FZD9/CTNNA1	-0.429056928297984
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/909	49/9376	0.842010731685413	JUN/CREB3/GNAI3/GNAI1	-0.363293342520277
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/909	61/9376	0.845461595339862	FTH1/HMOX1/MT1E/HMOX2/MT1F	-0.396746142081137
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/909	50/9376	0.825170517051705	HBA2/HBA1/HBB/IL18	-0.406120366740691
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/909	109/9376	0.851666818057953	HSP90AB1/JUN/FOS/MAPK9/RXRA/NFKBIA/CHUK/MAPK13/JAK1	-0.510369579463806
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/909	75/9376	0.825170517051705	IGFBP3/GADD45B/TP53I3/CCNB2/CYCS/GADD45A	-0.498061855969204
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/909	155/9376	0.865098122715497	TUBB6/TUBA1C/RAC1/VAMP3/ACTG1/ATP6V1D/DYNC1LI1/M6PR/SEC61A2/DYNC1I2/ITGA2/ATP6V1H/EEA1	-0.554878159999378
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/909	155/9376	0.865098122715497	RAP1B/CREB3/WNT7A/RAP1A/WNT11/WNT6/GNAI3/GNA11/KMT2A/ORAI1/GNAI1/TCF7/FZD9	-0.554878159999378
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/909	87/9376	0.829912876345106	TPM1/TPM3/MT-CO1/MT-CYB/COX7A2L/MT-CO3/MT-CO2	-0.522215047364919
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/909	52/9376	0.793433189472794	VDAC2/VDAC3/ANGPTL4/VDAC1	-0.489399907810413
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/909	99/9376	0.8335055727795	JUN/FOS/RAF1/MAPK9/GRB2/NRAS/NCOR1/MAPK13	-0.545652715205724
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/909	76/9376	0.814313010248393	CA2/CALM1/CALM3/GNAI3/ACTG1/GNAI1	-0.532536767203092
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/909	14/9376	0.736759390224737	B4GALT4	-0.322950073340196
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/909	134/9376	0.846723478317981	CALM1/RAF1/RHOA/MYL6/CALM3/GNA11/PPP1R12C/ARHGEF1/PPP1CA/NPPB/ROCK2	-0.585528250060567
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/909	28/9376	0.736759390224737	MECR/ACAA2	-0.457062248580261
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/909	28/9376	0.736759390224737	A4GALT/B4GALT4	-0.457062248580261
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/909	28/9376	0.736759390224737	CA2/ATP6V1D	-0.457062248580261
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/909	158/9376	0.848672208993051	GADD45B/MAD2L2/CDC26/MAD2L1BP/HDAC1/YWHAH/ANAPC16/CCNB2/CDCA5/GADD45A/ANAPC5/SKP1/ORC4	-0.628538209518147
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/909	101/9376	0.817000511932381	JUN/RAC1/PIM1/MAPK9/VEGFA/NRAS/VEGFB/MAPK13	-0.605837849851576
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/909	78/9376	0.793433189472794	EEF1A1/JUN/FOS/NFKBIA/MAPK13/JAK1	-0.600227479367313
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/909	90/9376	0.802249113800269	CREB3/PRKAG1/ATG5/PPARG/EIF4E2/NRAS/ADIPOR1	-0.617629673863053
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/909	29/9376	0.711353894010091	CALM1/CALM3	-0.510071878530989
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/909	149/9376	0.830708574213126	RRAS2/RALA/RAF1/RHOA/RRAS/CYTH2/GRB2/NRAS/ARF1/DGKZ/PDGFA/AGPAT2	-0.682496826779207
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/909	30/9376	0.687642097543088	PIGF/PIGC	-0.561439593898555
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/909	30/9376	0.687642097543088	GART/CHUK	-0.561439593898555
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/909	16/9376	0.644664466446645	A4GALT	-0.46608326112058
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/909	69/9376	0.747437062546834	CALM1/CALM3/GNAI3/ORAI1/GNAI1	-0.689909473245355
NA	NA	hsa04517	IgSF CAM signaling	25/909	299/9376	0.862427379861732	TUBB6/MYL12A/RAP1B/TUBA1C/MYL12B/ARPC2/RAC1/ICAM3/VAV2/RHOA/ARPC1A/MYL6/RAP1A/MAPK9/PAK2/ACTG1/GRB2/ARPC3/ARPC5/ARPC5L/TJP1/CLMP/PARD3/MAPK13/PAK4	-0.792135058959627
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/909	17/9376	0.606743027243901	SCP2	-0.531727312540635
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/909	154/9376	0.803737516608804	TPM1/CALM1/TPM3/CREB3/CALM3/GNAI3/PPP2R2D/PPP1CA/GNAI1/MAPK13/PPP2R3C/CREM	-0.804614567632831
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/909	83/9376	0.745636009384071	SLC25A17/PRDX5/ECH1/SCP2/ABCD4/PMVK	-0.76263987244658
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/909	201/9376	0.821065191096224	IGFBP3/CEBPB/GADD45B/PLAU/PPARG/MAX/NCOR1/HDAC1/ATF1/RXRA/KMT2A/PDGFA/PRCC/GADD45A/ETV4/FUS	-0.840219247485718
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/909	59/9376	0.699297048348903	LAP3/SMS/PRDX6/TXNDC12	-0.759151490566534
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/909	109/9376	0.757037171607069	CREB3/PRKAG1/MAPK9/MLX/NFKBIA/PYGL/PPP1CA/PTPN1	-0.835961549053018
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/909	97/9376	0.74435484785592	FOS/CALM1/CALM3/GNAI3/GNB2/GNAI1/GNG10	-0.829231213486125
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/909	47/9376	0.65838073169019	PKM/MAPK9/HK2	-0.769266004598989
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/909	122/9376	0.760915435805876	PFKP/MED4/RAF1/ACTG1/NRAS/NCOR1/HDAC1/RXRA/MED30	-0.870902436826517
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/909	73/9376	0.706481607064816	GADD45B/RAF1/NRAS/PDGFA/GADD45A	-0.824874808265586
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/909	98/9376	0.736759390224737	CALM1/CREB3/CALM3/GNA11/ATF1/ORAI1/PRKD3	-0.858304801043811
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/909	86/9376	0.719625450917185	EMD/ACTG1/ITGA2/LMNA/TCF7/CTNNA1	-0.855820640862487
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/909	99/9376	0.729317376182063	CALM1/CYP2J2/CALM3/MAPK9/MAP2K3/PPP1CA/MAPK13	-0.887109022872337
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/909	99/9376	0.729317376182063	TPM1/TPM3/PRKAG1/EMD/ACTG1/ITGA2/LMNA	-0.887109022872337
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/909	89/9376	0.695368413245819	GABARAP/GNAI3/GNB2/GNAI1/TRAK2/GNG10	-0.946095579042621
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/909	36/9376	0.573035081285906	UGP2/AKR1A1	-0.840955093149499
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/909	36/9376	0.573035081285906	ST6GALNAC2/C1GALT1C1	-0.840955093149499
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/909	115/9376	0.717539580044961	FOS/CREB3/GNAI3/GNA11/GNB2/NRAS/GNAI1/GNG10	-0.998574286015314
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/909	37/9376	0.557547646656558	GLUD1/ADSL	-0.88352732114463
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/909	37/9376	0.557547646656558	FAHD1/ADH5	-0.88352732114463
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/909	65/9376	0.634746551578235	DGKZ/AKR1A1/MGLL/AGPAT2	-0.968178958372276
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/909	65/9376	0.634746551578235	KISS1R/RAF1/GNA11/NRAS	-0.968178958372276
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/909	79/9376	0.652824776148501	CLTB/STX3/ATP6V1D/SLC1A6/ATP6V1H	-1.01529828896768
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/909	22/9376	0.468846884688469	CNDP2	-0.817212856870415
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/909	38/9376	0.542875340165595	ORAI1/RFXANK	-0.925129039655008
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/909	250/9376	0.78391199119912	CLTB/CD63/DTNBP1/AP3S1/BLOC1S4/CTSV/LAPTM4A/LITAF/ATP6V1D/M6PR/BORCS8/LAMTOR2/BORCS6/RRAGC/MCOLN1/RRAGA/AP1M2/ATP6V1H/CTBS	-1.13465345434581
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/909	23/9376	0.448462237528101	GLUD1	-0.867693818771376
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/909	95/9376	0.651450408198715	JUN/FOS/ATP6V1D/IL18/VEGFA/ATP6V1H	-1.11874677061896
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/909	24/9376	0.42977631096443	B4GALT7	-0.916434493446146
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/909	41/9376	0.50315275429982	GCSH/GRHPR	-1.04462509283344
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/909	42/9376	0.491172926816491	ACAT2/DLST	-1.08283867215316
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/909	26/9376	0.396716594736397	ABCD4	-1.00926461635095
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/909	43/9376	0.479750300611456	ACAT2/AGPAT2	-1.12031005209207
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/909	59/9376	0.524472786261677	GNAI3/GNAI1/MGLL	-1.20051097314555
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/909	27/9376	0.382023387523938	ACAT2	-1.05359606877926
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/909	191/9376	0.702042979167027	CALM1/CREB3/RAF1/CALM3/GNAI3/GNB2/GRB2/NRAS/HDAC1/PPP1CA/GNAI1/HAT1/GNG10	-1.36311823161172
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/909	115/9376	0.627847132539341	CYP2J2/RAF1/GNAI3/GNB2/NRAS/GNAI1/GNG10	-1.31566144372452
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/909	102/9376	0.606743027243901	CA2/RAP1B/RAC1/RAB8A/RHOA/RAP1A	-1.3084157755693
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/909	45/9376	0.458428065028725	ABCD4/ABCB10	-1.19316666822248
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/909	89/9376	0.579473677704849	LAMA3/LAMB3/LAMC2/ITGA2/SV2A	-1.30603033859237
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/909	28/9376	0.368379695112368	PTS	-1.0966765236084
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/909	168/9376	0.675362774372675	RAF1/PIM1/IFNAR1/STAT4/IRF9/GRB2/PDGFA/PIAS4/PTPN2/STAM/JAK1	-1.39114725669987
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/909	105/9376	0.589407512179789	TPM1/TPM3/EMD/ACTG1/ITGA2/LMNA	-1.38626148803916
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/909	30/9376	0.343821048771544	CYP2J2	-1.17943180244432
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/909	31/9376	0.332730047198268	AKR1A1	-1.21925785720087
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/909	31/9376	0.332730047198268	CNDP2	-1.21925785720087
NA	NA	hsa04981	Folate transport and metabolism	1/909	31/9376	0.332730047198268	MTHFS	-1.21925785720087
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/909	65/9376	0.476059913683676	CREB3/GNA11/ORAI1	-1.38881034309488
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/909	66/9376	0.468846884688469	JUN/STAT4/IL18	-1.41879503576054
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	26/909	362/9376	0.740829884093382	HSP90AB1/RPS6/LAMA3/CREB3/CDC37/RAC1/RAF1/FGFR3/IFNAR1/LAMB3/GNB2/GRB2/LAMC2/EIF4E2/PPP2R2D/VEGFA/NRAS/RXRA/VEGFB/YWHAH/PDGFA/ITGA2/CHUK/PPP2R3C/GNG10/JAK1	-1.6477193097933
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/909	51/9376	0.404495351495934	LPCAT1/GDPD3	-1.39716797888666
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/909	98/9376	0.526256707303383	IMPA2/CALM1/CALM3/DGKZ/PIP4K2A	-1.54465583000644
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/909	52/9376	0.396716594736397	CYP2J2/HSD17B7	-1.42930436000837
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/909	70/9376	0.442055634134842	RAC1/ACTG1/CYCS	-1.53518667525235
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/909	54/9376	0.382023387523938	RAD51/POLI	-1.49216610255067
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/909	116/9376	0.533515420507568	GNAI3/GNB2/HOMER3/SLC1A6/GNAI1/GNG10	-1.65639378807965
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/909	38/9376	0.271437670082798	NEDD4L	-1.47446468726776
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/909	91/9376	0.453390393984453	GNAI3/GNB2/GNAI1/GNG10	-1.71676085335104
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/909	217/9376	0.617927230511069	HSP90AB1/JUN/FOS/KLF4/CREB3/RAF1/PTGES3/GNAI3/GRB2/VEGFA/NRAS/RXRA/GNAI1	-1.86575547085901
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/909	78/9376	0.396716594736397	IMPA2/TPI1/PIP4K2A	-1.75297898419073
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/909	63/9376	0.327448617877661	CYP2J2/PTGES3	-1.7549055307559
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/909	99/9376	0.41675278638975	KRT19/KRT18/KRT17/KRT15	-1.91147794587218
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/909	133/9376	0.465321720141939	RAC1/VAV2/RAF1/IFNAR1/GRB2/NRAS	-2.03476700226601
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/909	103/9376	0.400568212161022	LAMA3/LAMB3/GNA11/LAMC2	-2.0042461232217
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/909	48/9376	0.214888155482215	HK2	-1.7867371988252
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/909	104/9376	0.396716594736397	LPCAT1/LYPLA2/DGKZ/AGPAT2	-2.02700181367234
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/909	49/9376	0.210502682921353	C1GALT1C1	-1.8154341892462
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/909	195/9376	0.528955459648529	VDAC2/RAC1/RAF1/VDAC3/ACTG1/HDAC1/HAT1/MAPK13/SLC25A4/VDAC1	-2.17789574479659
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/909	157/9376	0.459888027019262	CEBPB/RAC1/PPARG/RXRA/CRK/CASP7/MAPK13	-2.23611699979607
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/909	53/9376	0.194615687983893	CLTB	-1.92648689209248
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/909	75/9376	0.275056839017235	CREB3/TTF1	-2.06524969440104
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/909	55/9376	0.187538753875388	SPTLC1	-1.97995602780269
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/909	56/9376	0.184189847556184	DPM1	-2.00621726210489
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/909	100/9376	0.309438943894389	ACKR3/IL18/PF4	-2.27470201745644
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/909	254/9376	0.527914208743709	CALM1/VDAC2/FGFR3/VDAC3/CALM3/GNA11/VEGFA/VEGFB/ORAI1/MCOLN1/PDGFA/SLC25A4/VDAC1	-2.499168588053
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/909	323/9376	0.574809183704748	TPM1/UBE2I/HMOX1/RAF1/PIM1/RHOA/FGFR3/PLAU/RASSF1/GRB2/VEGFA/NRAS/HDAC1/CDCA5/CRK/PDGFA/SOX4/PAK4	-2.54795454803473
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/909	86/9376	0.239875150305728	CREB3/GNA11	-2.32021964236384
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/909	143/9376	0.360651449760361	TRIM21/SSB/SNRPD1/SNRPB/SNRPD3	-2.52427743810843
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/909	88/9376	0.234423442344234	PLAU/CLU	-2.36413166146728
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/909	66/9376	0.156282294896156	HSD17B7	-2.25370511266325
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/909	90/9376	0.229214032514363	CA2/RXRA	-2.40737371581508
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/909	68/9376	0.151685756810975	ADH5	-2.30030714201967
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/909	93/9376	0.221820031465512	CALM1/CALM3	-2.47104210873477
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/909	73/9376	0.141296321412963	ADH5	-2.41321514862563
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/909	75/9376	0.137528419508618	CYCS	-2.457046654009
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/909	160/9376	0.322332233223322	CLDN7/CD99/ICAM3/CLDN4/CLDN19	-2.83275090623507
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/909	79/9376	0.1305649552297	ADH5	-2.54262358797068
NA	NA	hsa04081	Hormone signaling	8/909	219/9376	0.376790190434569	RHOA/GNAI3/GNA11/GNB2/ADIPOR1/GNAI1/GNG10/NPPB	-3.05761310375711
NA	NA	hsa04082	Neuroactive ligand signaling	6/909	199/9376	0.310993913461698	GNAI3/GNA11/GNB2/SLC1A6/GNAI1/GNG10	-3.21885957479383
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/909	100/9376	0.103146314631463	ITGA2	-2.95422811557891
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/909	103/9376	0.100142053040255	COL5A1	-3.0087440109679
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/909	298/9376	0.207677143553281	INHA/TNFRSF12A/IFNAR1/ACKR3/IL18/PF4	-4.55426216577562
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/909	370/9376	0.139386911664139	KISS1R/NPFFR2/LYPD6B/NPB/CHRNB1	-5.53408260332488
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/909	449/9376	0.0459449062946384	CALM1/CALM3	-6.78807539887751