ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 63/1833 175/18639 0.36 3.66068739770867 6.03818257988129e-21 6.80503176752621e-18 GO:0045296 cadherin binding 91/1833 334/18639 0.272455089820359 2.77048031596382 5.68234416110031e-20 3.20200093478002e-17 GO:0019843 rRNA binding 26/1833 65/18639 0.4 4.06743044189853 1.21227594207268e-10 4.55411662238638e-08 GO:0003712 transcription coregulator activity 94/1833 495/18639 0.18989898989899 1.93100233100233 2.68585112204335e-10 7.56738553635713e-08 GO:0043021 ribonucleoprotein complex binding 46/1833 177/18639 0.259887005649718 2.64268079558379 5.01764524742687e-10 1.13097723877002e-07 GO:0042393 histone binding 52/1833 247/18639 0.210526315789474 2.14075286415712 9.40248232512573e-08 1.76609959673612e-05 GO:0051082 unfolded protein binding 32/1833 121/18639 0.264462809917355 2.68921020951969 1.35814666277495e-07 2.18661612706767e-05 GO:0003713 transcription coactivator activity 52/1833 256/18639 0.203125 2.0654920212766 3.09971751509677e-07 4.36672704939257e-05 GO:0019003 GDP binding 23/1833 75/18639 0.306666666666667 3.11836333878887 4.5130914368475e-07 5.65139338814126e-05 GO:0140297 DNA-binding transcription factor binding 81/1833 488/18639 0.165983606557377 1.68781693541896 1.73096977439071e-06 0.000189158739060312 GO:0044183 protein folding chaperone 22/1833 75/18639 0.293333333333333 2.98278232405892 1.84626985773153e-06 0.000189158739060312 GO:0003714 transcription corepressor activity 42/1833 204/18639 0.205882352941176 2.09353037450659 2.86985080673092e-06 0.000269526821598813 GO:0008135 translation factor activity, RNA binding 23/1833 83/18639 0.27710843373494 2.81779819770079 3.20675799555514e-06 0.000278001250845434 GO:0003743 translation initiation factor activity 17/1833 51/18639 0.333333333333333 3.38952536824877 3.95837303123272e-06 0.00030119574001101 GO:0180051 translation factor activity 23/1833 84/18639 0.273809523809524 2.78425298106149 4.00881641540829e-06 0.00030119574001101 GO:0043022 ribosome binding 27/1833 112/18639 0.241071428571429 2.45135316810849 8.48230420508841e-06 0.000597472302445915 GO:0140662 ATP-dependent protein folding chaperone 14/1833 40/18639 0.35 3.55900163666121 1.4841588336113e-05 0.000983910003223489 GO:0031072 heat shock protein binding 29/1833 131/18639 0.221374045801527 2.25105883234842 2.31284405105921e-05 0.0014480973586354 GO:0005525 GTP binding 61/1833 378/18639 0.161375661375661 1.64096069415218 7.37859986150226e-05 0.00429374749737066 GO:0140566 histone reader activity 12/1833 35/18639 0.342857142857143 3.48636895019874 7.61978260402956e-05 0.00429374749737066 GO:0061650 ubiquitin-like protein conjugating enzyme activity 13/1833 41/18639 0.317073170731707 3.22418266735859 9.70003650539942e-05 0.00520568625789769 GO:0005484 SNAP receptor activity 12/1833 36/18639 0.333333333333333 3.38952536824877 0.000104131896051159 0.00533439303862072 GO:0140517 protein-RNA adaptor activity 9/1833 22/18639 0.409090909090909 4.15987204285077 0.000127674682614828 0.00625605944812656 GO:0098641 cadherin binding involved in cell-cell adhesion 8/1833 18/18639 0.444444444444444 4.51936715766503 0.000152609064057903 0.00703551096808878 GO:0140463 chromatin-protein adaptor activity 15/1833 54/18639 0.277777777777778 2.82460447354064 0.000156067235316965 0.00703551096808878 GO:0140104 molecular carrier activity 43/1833 249/18639 0.172690763052209 1.7560191666831 0.000182940432263651 0.00792976412158211 GO:0019001 guanyl nucleotide binding 62/1833 400/18639 0.155 1.57612929623568 0.00020643120814751 0.00830885612793726 GO:0032561 guanyl ribonucleotide binding 62/1833 400/18639 0.155 1.57612929623568 0.00020643120814751 0.00830885612793726 GO:0044389 ubiquitin-like protein ligase binding 52/1833 322/18639 0.161490683229814 1.64213030262984 0.000238135873835432 0.00925445275215627 GO:0042809 nuclear vitamin D receptor binding 7/1833 15/18639 0.466666666666667 4.74533551554828 0.000277615266226846 0.0104290801679219 GO:0140030 modification-dependent protein binding 32/1833 173/18639 0.184971098265896 1.88089268989527 0.000338857638008359 0.0123191147753361 GO:0043024 ribosomal small subunit binding 8/1833 20/18639 0.4 4.06743044189853 0.000367060359118244 0.0129274070226957 GO:0031625 ubiquitin protein ligase binding 48/1833 302/18639 0.158940397350993 1.6161975265822 0.000583117836846244 0.0199143576401732 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 53/1833 349/18639 0.151862464183381 1.54422502450302 0.0009317528357844 0.0301526368169646 GO:0019208 phosphatase regulator activity 23/1833 117/18639 0.196581196581197 1.99895085819799 0.000936417292452318 0.0301526368169646 GO:0046966 nuclear thyroid hormone receptor binding 9/1833 28/18639 0.321428571428571 3.26847089081132 0.00102885717785001 0.0322089455399156 GO:0003924 GTPase activity 50/1833 331/18639 0.151057401812689 1.53603868651757 0.00143557100373295 0.0437267167893792 GO:0048027 mRNA 5'-UTR binding 8/1833 24/18639 0.333333333333333 3.38952536824877 0.00149835144139469 0.0444379493276794 GO:0019888 protein phosphatase regulator activity 21/1833 107/18639 0.196261682242991 1.99570185233339 0.00156093789095109 0.0451071026436379 GO:0001098 basal transcription machinery binding 14/1833 60/18639 0.233333333333333 2.37266775777414 0.00169986577708382 0.0467255787993528 GO:0001099 basal RNA polymerase II transcription machinery binding 14/1833 60/18639 0.233333333333333 2.37266775777414 0.00169986577708382 0.0467255787993528 GO:0016922 nuclear receptor binding 25/1833 137/18639 0.182481751824818 1.85557958115809 0.00174762615080855 0.0468946350466962 GO:0003925 G protein activity 13/1833 54/18639 0.240740740740741 2.44799054373522 0.00181744212816277 0.0476338901962661 GO:0055106 ubiquitin-protein transferase regulator activity 10/1833 36/18639 0.277777777777778 2.82460447354064 0.00191755619068425 0.049115586975026 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/1833 15/18639 0.4 4.06743044189853 0.00205253274603134 0.051404542328385 GO:0060590 ATPase regulator activity 12/1833 49/18639 0.244897959183673 2.49026353585624 0.00230318372465493 0.0555128646510376 GO:0003727 single-stranded RNA binding 18/1833 89/18639 0.202247191011236 2.05656595376892 0.00231508841046918 0.0555128646510376 GO:0070990 snRNP binding 5/1833 11/18639 0.454545454545455 4.62208004761196 0.00254361547824906 0.0583053036091764 GO:1990948 ubiquitin ligase inhibitor activity 5/1833 11/18639 0.454545454545455 4.62208004761196 0.00254361547824906 0.0583053036091764 GO:0140034 methylation-dependent protein binding 16/1833 76/18639 0.210526315789474 2.14075286415712 0.00258674816367242 0.0583053036091764 GO:0140597 protein carrier chaperone 31/1833 188/18639 0.164893617021277 1.67673329386774 0.00286824823532473 0.0628826850204727 GO:0030515 snoRNA binding 9/1833 32/18639 0.28125 2.8599120294599 0.00291378473157919 0.0628826850204727 GO:0042162 telomeric DNA binding 10/1833 38/18639 0.263157894736842 2.6759410801964 0.00297416470758058 0.0628826850204727 GO:0055102 lipase inhibitor activity 6/1833 16/18639 0.375 3.81321603927987 0.00301301241446808 0.0628826850204727 GO:0001671 ATPase activator activity 8/1833 27/18639 0.296296296296296 3.01291143844335 0.00346318142299413 0.070963735703898 GO:0004859 phospholipase inhibitor activity 5/1833 12/18639 0.416666666666667 4.23690671031097 0.00400960079588533 0.0792775455607503 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/1833 12/18639 0.416666666666667 4.23690671031097 0.00400960079588533 0.0792775455607503 GO:0032977 membrane insertase activity 6/1833 17/18639 0.352941176470588 3.58890921343988 0.00427301575431183 0.082207192023168 GO:0015036 disulfide oxidoreductase activity 10/1833 40/18639 0.25 2.54214402618658 0.00444954632955923 0.082207192023168 GO:0061791 GTPase motor activity 10/1833 40/18639 0.25 2.54214402618658 0.00444954632955923 0.082207192023168 GO:1990606 membrane scission GTPase motor activity 10/1833 40/18639 0.25 2.54214402618658 0.00444954632955923 0.082207192023168 GO:0015035 protein-disulfide reductase activity 9/1833 34/18639 0.264705882352941 2.69168191007991 0.00455361939629934 0.0824936041900944 GO:0140296 general transcription initiation factor binding 12/1833 53/18639 0.226415094339623 2.30231911805577 0.00461144371248975 0.0824936041900944 GO:0031491 nucleosome binding 15/1833 74/18639 0.202702702702703 2.0611978590702 0.00505237284408198 0.0876003722350829 GO:0035064 methylated histone binding 15/1833 74/18639 0.202702702702703 2.0611978590702 0.00505237284408198 0.0876003722350829 GO:0016853 isomerase activity 29/1833 180/18639 0.161111111111111 1.63827059465357 0.0053748399703921 0.0909965011064065 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/1833 54/18639 0.222222222222222 2.25968357883252 0.00540972987944032 0.0909965011064065 GO:0051087 protein-folding chaperone binding 23/1833 134/18639 0.171641791044776 1.74535261499377 0.00573081500308121 0.0949798310069489 GO:0019887 protein kinase regulator activity 38/1833 255/18639 0.149019607843137 1.51531722345239 0.00625634231359389 0.102186924455367 GO:0051536 iron-sulfur cluster binding 15/1833 76/18639 0.197368421052632 2.0069558101473 0.00653378112345599 0.104533688737034 GO:0016887 ATP hydrolysis activity 57/1833 417/18639 0.136690647482014 1.38994925172791 0.00667287194955889 0.104533688737034 GO:0031490 chromatin DNA binding 22/1833 128/18639 0.171875 1.74772401800327 0.00667928746645608 0.104533688737034 GO:0001091 RNA polymerase II general transcription initiation factor binding 7/1833 24/18639 0.291666666666667 2.96583469721768 0.00677103751357895 0.104533688737034 GO:0051721 protein phosphatase 2A binding 8/1833 30/18639 0.266666666666667 2.71162029459902 0.00700011575038352 0.106609870955165 GO:0051540 metal cluster binding 15/1833 77/18639 0.194805194805195 1.98089144897656 0.0073951859677036 0.111124994474693 GO:0019211 phosphatase activator activity 7/1833 25/18639 0.28 2.84720130932897 0.00862038805305227 0.127831280734078 GO:0009055 electron transfer activity 20/1833 116/18639 0.172413793103448 1.7532027766804 0.00908809178170901 0.133016616077741 GO:0003779 actin binding 59/1833 443/18639 0.133182844243792 1.35427988753958 0.0100028417498456 0.144528239129179 GO:0051059 NF-kappaB binding 8/1833 32/18639 0.25 2.54214402618658 0.0105460093972761 0.150447501148484 GO:0031386 protein tag activity 5/1833 15/18639 0.333333333333333 3.38952536824877 0.0118380761513736 0.161603927576536 GO:0140776 protein-containing complex destabilizing activity 5/1833 15/18639 0.333333333333333 3.38952536824877 0.0118380761513736 0.161603927576536 GO:0141047 molecular tag activity 5/1833 15/18639 0.333333333333333 3.38952536824877 0.0118380761513736 0.161603927576536 GO:0008140 cAMP response element binding protein binding 4/1833 10/18639 0.4 4.06743044189853 0.0120450132355182 0.161603927576536 GO:0031720 haptoglobin binding 4/1833 10/18639 0.4 4.06743044189853 0.0120450132355182 0.161603927576536 GO:0003684 damaged DNA binding 14/1833 74/18639 0.189189189189189 1.92378466846552 0.0122210614976528 0.162036897739466 GO:0140416 transcription regulator inhibitor activity 8/1833 33/18639 0.242424242424242 2.46510935872638 0.0127487760006357 0.163346658144604 GO:0016251 RNA polymerase II general transcription initiation factor activity 11/1833 53/18639 0.207547169811321 2.11045919155112 0.0127546636350711 0.163346658144604 GO:0016860 intramolecular oxidoreductase activity 11/1833 53/18639 0.207547169811321 2.11045919155112 0.0127546636350711 0.163346658144604 GO:1904047 S-adenosyl-L-methionine binding 6/1833 21/18639 0.285714285714286 2.90530745849895 0.0133128028338166 0.167971322009706 GO:0051015 actin filament binding 31/1833 209/18639 0.148325358851675 1.50825769974706 0.0134138589005089 0.167971322009706 GO:0140223 general transcription initiation factor activity 13/1833 68/18639 0.191176470588235 1.94399249061327 0.0141720143100327 0.17551494645502 GO:0017069 snRNA binding 11/1833 54/18639 0.203703703703704 2.07137661392981 0.0146336001772092 0.179261602170813 GO:0019207 kinase regulator activity 40/1833 287/18639 0.139372822299652 1.41722315048729 0.0152359214347654 0.184633155451404 GO:0017070 U6 snRNA binding 5/1833 16/18639 0.3125 3.17768003273322 0.015849468759058 0.186066159286024 GO:0030275 LRR domain binding 5/1833 16/18639 0.3125 3.17768003273322 0.015849468759058 0.186066159286024 GO:0043023 ribosomal large subunit binding 5/1833 16/18639 0.3125 3.17768003273322 0.015849468759058 0.186066159286024 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/1833 41/18639 0.219512195121951 2.23212646201748 0.0162967670108863 0.187558381639147 GO:0051537 2 iron, 2 sulfur cluster binding 7/1833 28/18639 0.25 2.54214402618658 0.0163719434040717 0.187558381639147 GO:0004407 histone deacetylase activity 6/1833 22/18639 0.272727272727273 2.77324802856718 0.0168152790400174 0.187558381639147 GO:0033558 protein lysine deacetylase activity 6/1833 22/18639 0.272727272727273 2.77324802856718 0.0168152790400174 0.187558381639147 GO:0070034 telomerase RNA binding 6/1833 22/18639 0.272727272727273 2.77324802856718 0.0168152790400174 0.187558381639147 GO:0003724 RNA helicase activity 14/1833 77/18639 0.181818181818182 1.84883201904479 0.0170865297972132 0.187558381639147 GO:0005536 D-glucose binding 4/1833 11/18639 0.363636363636364 3.69766403808957 0.0174743833825292 0.187558381639147 GO:0015217 ADP transmembrane transporter activity 4/1833 11/18639 0.363636363636364 3.69766403808957 0.0174743833825292 0.187558381639147 GO:0043522 leucine zipper domain binding 4/1833 11/18639 0.363636363636364 3.69766403808957 0.0174743833825292 0.187558381639147 GO:0061631 ubiquitin conjugating enzyme activity 8/1833 35/18639 0.228571428571429 2.32424596679916 0.0181342196641091 0.19280439208916 GO:0140098 catalytic activity, acting on RNA 51/1833 387/18639 0.131782945736434 1.34004491302858 0.0188821678759423 0.19627352004063 GO:0031492 nucleosomal DNA binding 9/1833 42/18639 0.214285714285714 2.17898059387421 0.0189829757625809 0.19627352004063 GO:0051879 Hsp90 protein binding 9/1833 42/18639 0.214285714285714 2.17898059387421 0.0189829757625809 0.19627352004063 GO:0035091 phosphatidylinositol binding 39/1833 284/18639 0.137323943661972 1.39638897213066 0.0203986187845037 0.205008984217183 GO:0004659 prenyltransferase activity 5/1833 17/18639 0.294117647058824 2.99075767786656 0.0206729908443689 0.205008984217183 GO:0031489 myosin V binding 5/1833 17/18639 0.294117647058824 2.99075767786656 0.0206729908443689 0.205008984217183 GO:0070577 lysine-acetylated histone binding 6/1833 23/18639 0.260869565217391 2.65267202732513 0.0209030819685441 0.205008984217183 GO:0008186 ATP-dependent activity, acting on RNA 14/1833 79/18639 0.177215189873418 1.80202614514492 0.0210685589095945 0.205008984217183 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/1833 36/18639 0.222222222222222 2.25968357883252 0.0213628705504249 0.205008984217183 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/1833 36/18639 0.222222222222222 2.25968357883252 0.0213628705504249 0.205008984217183 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/1833 36/18639 0.222222222222222 2.25968357883252 0.0213628705504249 0.205008984217183 GO:0019787 ubiquitin-like protein transferase activity 61/1833 479/18639 0.127348643006263 1.29495436824536 0.0214650045586757 0.205008984217183 GO:0000049 tRNA binding 14/1833 80/18639 0.175 1.77950081833061 0.0233032338842294 0.22069533266829 GO:0008408 3'-5' exonuclease activity 11/1833 58/18639 0.189655172413793 1.92852305434844 0.0242779322638369 0.228010247177869 GO:0030544 Hsp70 protein binding 10/1833 51/18639 0.196078431372549 1.99383845191104 0.0249827127897365 0.229871651575388 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 20/1833 128/18639 0.15625 1.58884001636661 0.0250835601794654 0.229871651575388 GO:0032182 ubiquitin-like protein binding 19/1833 120/18639 0.158333333333333 1.61002454991817 0.0251630962694462 0.229871651575388 GO:0001046 core promoter sequence-specific DNA binding 9/1833 44/18639 0.204545454545455 2.07993602142538 0.0252920007057215 0.229871651575388 GO:0140033 acetylation-dependent protein binding 6/1833 24/18639 0.25 2.54214402618658 0.0256137634535324 0.230933691297049 GO:1990381 ubiquitin-specific protease binding 5/1833 18/18639 0.277777777777778 2.82460447354064 0.0263614895940367 0.235788879146662 GO:0035402 histone H3T11 kinase activity 34/1833 247/18639 0.137651821862348 1.39972302656427 0.0279265331565287 0.247820495018959 GO:0000287 magnesium ion binding 32/1833 230/18639 0.139130434782609 1.4147584145734 0.0281934779895134 0.248234763235793 GO:0004674 protein serine/threonine kinase activity 55/1833 433/18639 0.1270207852194 1.2916205213881 0.0290302203161269 0.253620606947869 GO:0004386 helicase activity 23/1833 155/18639 0.148387096774194 1.50888548651074 0.0298286672628507 0.258318465534913 GO:0003725 double-stranded RNA binding 13/1833 75/18639 0.173333333333333 1.76255319148936 0.030222366984309 0.258318465534913 GO:0140097 catalytic activity, acting on DNA 44/1833 336/18639 0.130952380952381 1.33159925181202 0.030255578926893 0.258318465534913 GO:0140713 histone chaperone activity 24/1833 164/18639 0.146341463414634 1.48808430801166 0.0311735767501765 0.263798723957052 GO:0001221 transcription coregulator binding 18/1833 115/18639 0.156521739130435 1.59160321639508 0.0318552865297957 0.263798723957052 GO:1990841 promoter-specific chromatin binding 12/1833 68/18639 0.176470588235294 1.79445460671994 0.0321648901425086 0.263798723957052 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/1833 13/18639 0.307692307692308 3.12879264761425 0.0323018845661697 0.263798723957052 GO:0005172 vascular endothelial growth factor receptor binding 4/1833 13/18639 0.307692307692308 3.12879264761425 0.0323018845661697 0.263798723957052 GO:0019104 DNA N-glycosylase activity 4/1833 13/18639 0.307692307692308 3.12879264761425 0.0323018845661697 0.263798723957052 GO:0017022 myosin binding 13/1833 76/18639 0.171052631578947 1.73936170212766 0.0332965367639945 0.269221909041089 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/1833 39/18639 0.205128205128205 2.08586176507617 0.0334437154088309 0.269221909041089 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 33/1833 243/18639 0.135802469135802 1.38091774261987 0.0354248886296433 0.27732416326373 GO:0140658 ATP-dependent chromatin remodeler activity 23/1833 158/18639 0.145569620253165 1.48023576208332 0.0361981051593135 0.27732416326373 GO:0004676 3-phosphoinositide-dependent protein kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0004711 ribosomal protein S6 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0035175 histone H3S10 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0035979 histone H2AXS139 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0044022 histone H3S28 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0044023 histone H4S1 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0044024 histone H2AS1 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0044025 histone H2BS14 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0072354 histone H3T3 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0072371 histone H2AS121 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0072518 Rho-dependent protein serine/threonine kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0140823 histone H2BS36 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0140855 histone H3S57 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0140995 histone H2A kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0140997 histone H4 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0140998 histone H2B kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:1990244 histone H2AT120 kinase activity 33/1833 245/18639 0.13469387755102 1.36964494472093 0.0391255918002955 0.27732416326373 GO:0016755 aminoacyltransferase activity 61/1833 496/18639 0.122983870967742 1.25057085159179 0.0397468077086958 0.279966576798126 GO:0000339 RNA cap binding 5/1833 20/18639 0.25 2.54214402618658 0.0404917554261049 0.281692644229754 GO:0016408 C-acyltransferase activity 5/1833 20/18639 0.25 2.54214402618658 0.0404917554261049 0.281692644229754 GO:0004677 DNA-dependent protein kinase activity 33/1833 246/18639 0.134146341463415 1.36407728234402 0.041081752789245 0.282311801179751 GO:0140857 histone H3T45 kinase activity 33/1833 246/18639 0.134146341463415 1.36407728234402 0.041081752789245 0.282311801179751 GO:0005344 oxygen carrier activity 4/1833 14/18639 0.285714285714286 2.90530745849895 0.0417921470528004 0.283733432099434 GO:0005347 ATP transmembrane transporter activity 4/1833 14/18639 0.285714285714286 2.90530745849895 0.0417921470528004 0.283733432099434 GO:0004857 enzyme inhibitor activity 52/1833 416/18639 0.125 1.27107201309329 0.0423590381277457 0.285860095628559 GO:0035403 histone H3T6 kinase activity 33/1833 247/18639 0.133603238866397 1.35855470225356 0.0431103614241964 0.289198674553984 GO:1902936 phosphatidylinositol bisphosphate binding 17/1833 111/18639 0.153153153153153 1.55734949351971 0.0433907879440312 0.289357503035048 GO:0016835 carbon-oxygen lyase activity 13/1833 79/18639 0.164556962025316 1.67330999192028 0.0438573322772999 0.290558773685685 GO:0016779 nucleotidyltransferase activity 20/1833 136/18639 0.147058823529412 1.49537883893328 0.0440865574980055 0.290558773685685 GO:0004679 AMP-activated protein kinase activity 33/1833 248/18639 0.133064516129032 1.35307665909931 0.045212815624295 0.296249088421979 GO:0008017 microtubule binding 36/1833 276/18639 0.130434782608696 1.32633601366256 0.0485410113073032 0.315050865746858 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/1833 21/18639 0.238095238095238 2.42108954874912 0.0489851781111949 0.315050865746858 GO:0072542 protein phosphatase activator activity 5/1833 21/18639 0.238095238095238 2.42108954874912 0.0489851781111949 0.315050865746858 GO:0016859 cis-trans isomerase activity 8/1833 42/18639 0.19047619047619 1.9368716389993 0.049480038364857 0.315050865746858 GO:0043175 RNA polymerase core enzyme binding 8/1833 42/18639 0.19047619047619 1.9368716389993 0.049480038364857 0.315050865746858 GO:0005154 epidermal growth factor receptor binding 7/1833 35/18639 0.2 2.03371522094926 0.0510289738201986 0.322740059344694 GO:0097718 disordered domain specific binding 6/1833 28/18639 0.214285714285714 2.17898059387421 0.0512603998426799 0.322740059344694 GO:0043539 protein serine/threonine kinase activator activity 12/1833 73/18639 0.164383561643836 1.6715467569446 0.051814198538735 0.324414454184191 GO:0000774 adenyl-nucleotide exchange factor activity 4/1833 15/18639 0.266666666666667 2.71162029459902 0.0526845364715011 0.324456134444709 GO:0004129 cytochrome-c oxidase activity 4/1833 15/18639 0.266666666666667 2.71162029459902 0.0526845364715011 0.324456134444709 GO:0008252 nucleotidase activity 4/1833 15/18639 0.266666666666667 2.71162029459902 0.0526845364715011 0.324456134444709 GO:0106310 protein serine kinase activity 45/1833 361/18639 0.124653739612188 1.26755103798777 0.0576901619438425 0.353352241906035 GO:0000993 RNA polymerase II complex binding 7/1833 36/18639 0.194444444444444 1.97722313147845 0.058189757368075 0.354485711101733 GO:0005048 signal sequence binding 9/1833 51/18639 0.176470588235294 1.79445460671994 0.0587534153631342 0.355995156528238 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/1833 29/18639 0.206896551724138 2.10384333201648 0.059468278580111 0.358399732405268 GO:0031593 polyubiquitin modification-dependent protein binding 10/1833 59/18639 0.169491525423729 1.72348747538073 0.0605000274884654 0.36075942317196 GO:0070063 RNA polymerase binding 10/1833 59/18639 0.169491525423729 1.72348747538073 0.0605000274884654 0.36075942317196 GO:0061659 ubiquitin-like protein ligase activity 46/1833 372/18639 0.123655913978495 1.25740457209229 0.0618481427478455 0.366857141456957 GO:0019205 nucleobase-containing compound kinase activity 8/1833 44/18639 0.181818181818182 1.84883201904479 0.0625388877838602 0.368270854547332 GO:0043130 ubiquitin binding 15/1833 100/18639 0.15 1.52528641571195 0.0642306431457398 0.368270854547332 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/1833 16/18639 0.25 2.54214402618658 0.0649628923756488 0.368270854547332 GO:0000510 H3-H4 histone complex chaperone activity 21/1833 151/18639 0.139072847682119 1.41417283575942 0.0656156326010276 0.368270854547332 GO:0140584 chromatin extrusion motor activity 21/1833 151/18639 0.139072847682119 1.41417283575942 0.0656156326010276 0.368270854547332 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 21/1833 151/18639 0.139072847682119 1.41417283575942 0.0656156326010276 0.368270854547332 GO:0140849 ATP-dependent H2AZ histone chaperone activity 21/1833 151/18639 0.139072847682119 1.41417283575942 0.0656156326010276 0.368270854547332 GO:0019213 deacetylase activity 7/1833 37/18639 0.189189189189189 1.92378466846552 0.0659392471653801 0.368270854547332 GO:0004527 exonuclease activity 13/1833 84/18639 0.154761904761905 1.57370820668693 0.0662828360349539 0.368270854547332 GO:0003689 DNA clamp loader activity 22/1833 160/18639 0.1375 1.39817921440262 0.0670411175853246 0.368270854547332 GO:0001094 TFIID-class transcription factor complex binding 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0005381 iron ion transmembrane transporter activity 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0016783 sulfurtransferase activity 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0030957 Tat protein binding 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0031434 mitogen-activated protein kinase kinase binding 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0045322 unmethylated CpG binding 3/1833 10/18639 0.3 3.0505728314239 0.0673148145845168 0.368270854547332 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1833 30/18639 0.2 2.03371522094926 0.0684124663748873 0.372467872485498 GO:0015616 DNA translocase activity 21/1833 152/18639 0.138157894736842 1.40486906710311 0.0693944345058256 0.374198697072084 GO:0140674 ATP-dependent histone chaperone activity 21/1833 152/18639 0.138157894736842 1.40486906710311 0.0693944345058256 0.374198697072084 GO:0051539 4 iron, 4 sulfur cluster binding 8/1833 45/18639 0.177777777777778 1.80774686306601 0.0698018724141417 0.374603381955894 GO:0019903 protein phosphatase binding 20/1833 144/18639 0.138888888888889 1.41230223677032 0.0717987012643426 0.383493537084901 GO:0019905 syntaxin binding 10/1833 61/18639 0.163934426229508 1.66697968930267 0.0728502524565297 0.385957697059936 GO:0002039 p53 binding 11/1833 69/18639 0.159420289855072 1.62107735003202 0.0729449773502807 0.385957697059936 GO:0061775 cohesin loader activity 21/1833 153/18639 0.137254901960784 1.39568691633773 0.0733192855919701 0.386125396552104 GO:0008327 methyl-CpG binding 6/1833 31/18639 0.193548387096774 1.96811150414445 0.078091741536708 0.406291535744052 GO:0004550 nucleoside diphosphate kinase activity 4/1833 17/18639 0.235294117647059 2.39260614229325 0.0785905543852735 0.406291535744052 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/1833 17/18639 0.235294117647059 2.39260614229325 0.0785905543852735 0.406291535744052 GO:0051787 misfolded protein binding 4/1833 17/18639 0.235294117647059 2.39260614229325 0.0785905543852735 0.406291535744052 GO:0035035 histone acetyltransferase binding 5/1833 24/18639 0.208333333333333 2.11845335515548 0.0802604897716149 0.413030009007352 GO:0008276 protein methyltransferase activity 14/1833 95/18639 0.147368421052632 1.49852700490998 0.0809261150151882 0.414306938289219 GO:0019902 phosphatase binding 25/1833 190/18639 0.131578947368421 1.3379705400982 0.0812438627878594 0.414306938289219 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/1833 39/18639 0.179487179487179 1.82512904444165 0.0832137955288547 0.422441205229816 GO:0008172 S-methyltransferase activity 3/1833 11/18639 0.272727272727273 2.77324802856718 0.0860049762852623 0.428883222449074 GO:0010854 adenylate cyclase regulator activity 3/1833 11/18639 0.272727272727273 2.77324802856718 0.0860049762852623 0.428883222449074 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/1833 11/18639 0.272727272727273 2.77324802856718 0.0860049762852623 0.428883222449074 GO:0019206 nucleoside kinase activity 3/1833 11/18639 0.272727272727273 2.77324802856718 0.0860049762852623 0.428883222449074 GO:0016407 acetyltransferase activity 14/1833 96/18639 0.145833333333333 1.48291734860884 0.0865941489479926 0.429918968565584 GO:0030295 protein kinase activator activity 19/1833 139/18639 0.136690647482014 1.38994925172791 0.0878924458369775 0.434450817799446 GO:0070717 poly-purine tract binding 6/1833 32/18639 0.1875 1.90660801963993 0.0884993110915851 0.435540277730203 GO:0019209 kinase activator activity 20/1833 148/18639 0.135135135135135 1.3741319060468 0.0893234392833498 0.437684852488414 GO:0008094 ATP-dependent activity, acting on DNA 27/1833 210/18639 0.128571428571429 1.30738835632453 0.0899123096639257 0.438663086542183 GO:0048306 calcium-dependent protein binding 12/1833 80/18639 0.15 1.52528641571195 0.0909742651494365 0.441931020790582 GO:0017025 TBP-class protein binding 5/1833 25/18639 0.2 2.03371522094926 0.0925805890826766 0.447803965219642 GO:0003746 translation elongation factor activity 4/1833 18/18639 0.222222222222222 2.25968357883252 0.0935131443256268 0.448465164489283 GO:0070628 proteasome binding 4/1833 18/18639 0.222222222222222 2.25968357883252 0.0935131443256268 0.448465164489283 GO:0000149 SNARE binding 15/1833 106/18639 0.141509433962264 1.43894944878486 0.095513311856835 0.454884670151243 GO:0015631 tubulin binding 46/1833 385/18639 0.119480519480519 1.21494675537229 0.0956589767753723 0.454884670151243 GO:1901981 phosphatidylinositol phosphate binding 24/1833 185/18639 0.12972972972973 1.31916662980493 0.0972473640391281 0.460494870891165 GO:0004601 peroxidase activity 9/1833 57/18639 0.157894736842105 1.60556464811784 0.103327851908087 0.486409444040861 GO:0008157 protein phosphatase 1 binding 5/1833 26/18639 0.192307692307692 1.95549540475891 0.105807012808513 0.486409444040861 GO:0050681 nuclear androgen receptor binding 5/1833 26/18639 0.192307692307692 1.95549540475891 0.105807012808513 0.486409444040861 GO:0070412 R-SMAD binding 5/1833 26/18639 0.192307692307692 1.95549540475891 0.105807012808513 0.486409444040861 GO:0016208 AMP binding 3/1833 12/18639 0.25 2.54214402618658 0.106604376821733 0.486409444040861 GO:0043047 single-stranded telomeric DNA binding 3/1833 12/18639 0.25 2.54214402618658 0.106604376821733 0.486409444040861 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1833 12/18639 0.25 2.54214402618658 0.106604376821733 0.486409444040861 GO:0097677 STAT family protein binding 3/1833 12/18639 0.25 2.54214402618658 0.106604376821733 0.486409444040861 GO:1990459 transferrin receptor binding 3/1833 12/18639 0.25 2.54214402618658 0.106604376821733 0.486409444040861 GO:0003756 protein disulfide isomerase activity 4/1833 19/18639 0.210526315789474 2.14075286415712 0.1096613724731 0.492383931383201 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/1833 19/18639 0.210526315789474 2.14075286415712 0.1096613724731 0.492383931383201 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/1833 19/18639 0.210526315789474 2.14075286415712 0.1096613724731 0.492383931383201 GO:0140036 ubiquitin-modified protein reader activity 4/1833 19/18639 0.210526315789474 2.14075286415712 0.1096613724731 0.492383931383201 GO:0019894 kinesin binding 7/1833 42/18639 0.166666666666667 1.69476268412439 0.113507168261947 0.507629280282595 GO:0042826 histone deacetylase binding 17/1833 127/18639 0.133858267716535 1.3611479825251 0.117706111980283 0.524327226093989 GO:0008320 protein transmembrane transporter activity 5/1833 27/18639 0.185185185185185 1.8830696490271 0.119903083438991 0.532010925337572 GO:0001786 phosphatidylserine binding 9/1833 59/18639 0.152542372881356 1.55113872784266 0.121539489327246 0.535058611217992 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/1833 59/18639 0.152542372881356 1.55113872784266 0.121539489327246 0.535058611217992 GO:0051219 phosphoprotein binding 13/1833 93/18639 0.139784946236559 1.42141386410432 0.123130735875069 0.538946033942824 GO:0005543 phospholipid binding 57/1833 497/18639 0.114688128772636 1.16621496573549 0.123378950095163 0.538946033942824 GO:0000175 3'-5'-RNA exonuclease activity 6/1833 35/18639 0.171428571428571 1.74318447509937 0.123945896165405 0.539332142773791 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/1833 20/18639 0.2 2.03371522094926 0.126953776734849 0.550245474657949 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/1833 68/18639 0.147058823529412 1.49537883893328 0.127667735638159 0.550245474657949 GO:0008253 5'-nucleotidase activity 3/1833 13/18639 0.230769230769231 2.34659448571069 0.128895124498402 0.550245474657949 GO:0089720 caspase binding 3/1833 13/18639 0.230769230769231 2.34659448571069 0.128895124498402 0.550245474657949 GO:0140666 annealing activity 3/1833 13/18639 0.230769230769231 2.34659448571069 0.128895124498402 0.550245474657949 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/1833 60/18639 0.15 1.52528641571195 0.13125370343385 0.558199712339428 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 28/1833 229/18639 0.122270742358079 1.24331934905195 0.134152254777336 0.56277123154385 GO:0016866 intramolecular transferase activity 5/1833 28/18639 0.178571428571429 1.81581716156184 0.134825405959929 0.56277123154385 GO:0019789 SUMO transferase activity 5/1833 28/18639 0.178571428571429 1.81581716156184 0.134825405959929 0.56277123154385 GO:0036408 histone H3K14 acetyltransferase activity 5/1833 28/18639 0.178571428571429 1.81581716156184 0.134825405959929 0.56277123154385 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/1833 28/18639 0.178571428571429 1.81581716156184 0.134825405959929 0.56277123154385 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 12/1833 86/18639 0.13953488372093 1.41887108438321 0.135948613603297 0.563287086510721 GO:0050660 flavin adenine dinucleotide binding 12/1833 86/18639 0.13953488372093 1.41887108438321 0.135948613603297 0.563287086510721 GO:0008080 N-acetyltransferase activity 10/1833 69/18639 0.144927536231884 1.47370668184729 0.136942779415766 0.565327884254827 GO:0005123 death receptor binding 4/1833 21/18639 0.19047619047619 1.9368716389993 0.145299329352179 0.591658892157861 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/1833 21/18639 0.19047619047619 1.9368716389993 0.145299329352179 0.591658892157861 GO:0004864 protein phosphatase inhibitor activity 8/1833 53/18639 0.150943396226415 1.53487941203718 0.145421040929661 0.591658892157861 GO:0005544 calcium-dependent phospholipid binding 8/1833 53/18639 0.150943396226415 1.53487941203718 0.145421040929661 0.591658892157861 GO:0097110 scaffold protein binding 10/1833 70/18639 0.142857142857143 1.45265372924947 0.146561978762298 0.594155935486008 GO:0046332 SMAD binding 11/1833 79/18639 0.139240506329114 1.41587768547101 0.15040540619829 0.59943238047205 GO:0010484 histone H3 acetyltransferase activity 5/1833 29/18639 0.172413793103448 1.7532027766804 0.150524807497391 0.59943238047205 GO:0016530 metallochaperone activity 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0030983 mismatched DNA binding 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0032036 myosin heavy chain binding 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0061665 SUMO ligase activity 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0070742 C2H2 zinc finger domain binding 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0071933 Arp2/3 complex binding 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0098847 sequence-specific single stranded DNA binding 3/1833 14/18639 0.214285714285714 2.17898059387421 0.152650481983565 0.59943238047205 GO:0034062 5'-3' RNA polymerase activity 4/1833 22/18639 0.181818181818182 1.84883201904479 0.164599866289968 0.63779518555448 GO:0097747 RNA polymerase activity 4/1833 22/18639 0.181818181818182 1.84883201904479 0.164599866289968 0.63779518555448 GO:0140035 ubiquitin-like protein reader activity 4/1833 22/18639 0.181818181818182 1.84883201904479 0.164599866289968 0.63779518555448 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/1833 38/18639 0.157894736842105 1.60556464811784 0.165230037196335 0.63779518555448 GO:0031210 phosphatidylcholine binding 5/1833 30/18639 0.166666666666667 1.69476268412439 0.166947275721891 0.63779518555448 GO:0043995 histone H4K5 acetyltransferase activity 5/1833 30/18639 0.166666666666667 1.69476268412439 0.166947275721891 0.63779518555448 GO:0043996 histone H4K8 acetyltransferase activity 5/1833 30/18639 0.166666666666667 1.69476268412439 0.166947275721891 0.63779518555448 GO:0043997 histone H4K12 acetyltransferase activity 5/1833 30/18639 0.166666666666667 1.69476268412439 0.166947275721891 0.63779518555448 GO:0098632 cell-cell adhesion mediator activity 8/1833 55/18639 0.145454545454545 1.47906561523583 0.168891777336248 0.643044030601188 GO:0003774 cytoskeletal motor activity 19/1833 153/18639 0.124183006535948 1.26276435287699 0.1718086457826 0.651947285511751 GO:0005504 fatty acid binding 7/1833 47/18639 0.148936170212766 1.51446878155796 0.174831231561197 0.658560849814152 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0005523 tropomyosin binding 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0045504 dynein heavy chain binding 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0141050 histone H3K deacetylase activity 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0141051 histone H4K deacetylase activity 3/1833 15/18639 0.2 2.03371522094926 0.177641968361581 0.658560849814152 GO:0000217 DNA secondary structure binding 6/1833 39/18639 0.153846153846154 1.56439632380713 0.180142081135876 0.663464462222656 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/1833 39/18639 0.153846153846154 1.56439632380713 0.180142081135876 0.663464462222656 GO:0019212 phosphatase inhibitor activity 8/1833 56/18639 0.142857142857143 1.45265372924947 0.181233120551421 0.66530855655196 GO:0000295 adenine nucleotide transmembrane transporter activity 4/1833 23/18639 0.173913043478261 1.76844801821675 0.184752310746379 0.671664045842481 GO:0003887 DNA-directed DNA polymerase activity 4/1833 23/18639 0.173913043478261 1.76844801821675 0.184752310746379 0.671664045842481 GO:0008171 O-methyltransferase activity 4/1833 23/18639 0.173913043478261 1.76844801821675 0.184752310746379 0.671664045842481 GO:0160215 deacylase activity 9/1833 65/18639 0.138461538461538 1.40795669142641 0.185504369713011 0.672229661307279 GO:0052689 carboxylic ester hydrolase activity 12/1833 92/18639 0.130434782608696 1.32633601366256 0.190937545238129 0.689700684241577 GO:0004532 RNA exonuclease activity 6/1833 40/18639 0.15 1.52528641571195 0.195566921121517 0.699694984456985 GO:0050997 quaternary ammonium group binding 6/1833 40/18639 0.15 1.52528641571195 0.195566921121517 0.699694984456985 GO:0071949 FAD binding 6/1833 40/18639 0.15 1.52528641571195 0.195566921121517 0.699694984456985 GO:0141003 histone H2AX kinase activity 40/1833 354/18639 0.112994350282486 1.14899165025382 0.19721967099902 0.703375219037644 GO:0004860 protein kinase inhibitor activity 11/1833 84/18639 0.130952380952381 1.33159925181202 0.200590221943495 0.713139369496274 GO:0022884 macromolecule transmembrane transporter activity 5/1833 32/18639 0.15625 1.58884001636661 0.201726650182816 0.714924323132182 GO:0016763 pentosyltransferase activity 7/1833 49/18639 0.142857142857143 1.45265372924947 0.202662891069915 0.714977338694936 GO:0000062 fatty-acyl-CoA binding 3/1833 16/18639 0.1875 1.90660801963993 0.203644832050643 0.714977338694936 GO:0097027 ubiquitin-protein transferase activator activity 3/1833 16/18639 0.1875 1.90660801963993 0.203644832050643 0.714977338694936 GO:0050699 WW domain binding 4/1833 24/18639 0.166666666666667 1.69476268412439 0.205650674941332 0.7175489494083 GO:0070840 dynein complex binding 4/1833 24/18639 0.166666666666667 1.69476268412439 0.205650674941332 0.7175489494083 GO:0061980 regulatory RNA binding 8/1833 58/18639 0.137931034482759 1.40256222134432 0.207028182181998 0.720125806540469 GO:0003697 single-stranded DNA binding 15/1833 121/18639 0.12396694214876 1.26056728571235 0.208363973439039 0.722481520039429 GO:0042054 histone methyltransferase activity 9/1833 67/18639 0.134328358208955 1.36592813347339 0.209602747906299 0.722481520039429 GO:0005200 structural constituent of cytoskeleton 14/1833 112/18639 0.125 1.27107201309329 0.209628622052257 0.722481520039429 GO:0140318 protein transporter activity 6/1833 41/18639 0.146341463414634 1.48808430801166 0.211463653894504 0.726583957131421 GO:0140996 histone H3 kinase activity 40/1833 357/18639 0.112044817927171 1.13933625823488 0.212686606541225 0.728564758577387 GO:0016741 transferase activity, transferring one-carbon groups 25/1833 215/18639 0.116279069767442 1.18239257031934 0.216038679153166 0.737804822441267 GO:0032813 tumor necrosis factor receptor superfamily binding 7/1833 50/18639 0.14 1.42360065466448 0.217178392199815 0.739456338396348 GO:0045309 protein phosphorylated amino acid binding 8/1833 59/18639 0.135593220338983 1.37878998030459 0.220438173218037 0.742023810792176 GO:0016209 antioxidant activity 11/1833 86/18639 0.127906976744186 1.30063182735127 0.222490012291328 0.742023810792176 GO:0004709 MAP kinase kinase kinase activity 4/1833 25/18639 0.16 1.62697217675941 0.227187834152504 0.742023810792176 GO:0042974 nuclear retinoic acid receptor binding 4/1833 25/18639 0.16 1.62697217675941 0.227187834152504 0.742023810792176 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/1833 25/18639 0.16 1.62697217675941 0.227187834152504 0.742023810792176 GO:0004402 histone acetyltransferase activity 6/1833 42/18639 0.142857142857143 1.45265372924947 0.227789734833263 0.742023810792176 GO:0008307 structural constituent of muscle 6/1833 42/18639 0.142857142857143 1.45265372924947 0.227789734833263 0.742023810792176 GO:0035198 miRNA binding 6/1833 42/18639 0.142857142857143 1.45265372924947 0.227789734833263 0.742023810792176 GO:0035173 histone kinase activity 40/1833 360/18639 0.111111111111111 1.12984178941626 0.228742607841588 0.742023810792176 GO:0004549 tRNA-specific ribonuclease activity 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0008429 phosphatidylethanolamine binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0016018 cyclosporin A binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0032183 SUMO binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0036041 long-chain fatty acid binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0038191 neuropilin binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0048038 quinone binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0070403 NAD+ binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:1901567 fatty acid derivative binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:1990226 histone methyltransferase binding 3/1833 17/18639 0.176470588235294 1.79445460671994 0.230442177264651 0.742023810792176 GO:0017124 SH3 domain binding 14/1833 115/18639 0.121739130434783 1.23791361275173 0.238761931394613 0.752777559071807 GO:0004842 ubiquitin-protein transferase activity 49/1833 449/18639 0.10913140311804 1.10971097802354 0.23962557818189 0.752777559071807 GO:0004518 nuclease activity 24/1833 209/18639 0.114832535885167 1.16768338044934 0.240554983811122 0.752777559071807 GO:0061630 ubiquitin protein ligase activity 39/1833 353/18639 0.110481586402266 1.12344041950455 0.243369745825465 0.752777559071807 GO:0016829 lyase activity 23/1833 200/18639 0.115 1.16938625204583 0.244123054936648 0.752777559071807 GO:0048156 tau protein binding 6/1833 43/18639 0.13953488372093 1.41887108438321 0.244501398365751 0.752777559071807 GO:0051020 GTPase binding 35/1833 315/18639 0.111111111111111 1.12984178941626 0.246444610176748 0.752777559071807 GO:0030159 signaling receptor complex adaptor activity 7/1833 52/18639 0.134615384615385 1.36884678333123 0.24725481628084 0.752777559071807 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 8/1833 61/18639 0.131147540983607 1.33358375144214 0.248165935269757 0.752777559071807 GO:0008143 poly(A) binding 4/1833 26/18639 0.153846153846154 1.56439632380713 0.249257074396866 0.752777559071807 GO:0015216 purine nucleotide transmembrane transporter activity 4/1833 26/18639 0.153846153846154 1.56439632380713 0.249257074396866 0.752777559071807 GO:0043548 phosphatidylinositol 3-kinase binding 4/1833 26/18639 0.153846153846154 1.56439632380713 0.249257074396866 0.752777559071807 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0004090 carbonyl reductase (NADPH) activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0005522 profilin binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0015643 toxic substance binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0016427 tRNA (cytidine) methyltransferase activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0016868 intramolecular phosphotransferase activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0031996 thioesterase binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0033204 ribonuclease P RNA binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0042975 peroxisome proliferator activated receptor binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0050815 phosphoserine residue binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0051880 G-quadruplex DNA binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0070513 death domain binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0097177 mitochondrial ribosome binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0098505 G-rich strand telomeric DNA binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0099122 RNA polymerase II C-terminal domain binding 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:1990757 ubiquitin ligase activator activity 2/1833 10/18639 0.2 2.03371522094926 0.257472664023723 0.752777559071807 GO:0010485 histone H4 acetyltransferase activity 5/1833 35/18639 0.142857142857143 1.45265372924947 0.257789135354195 0.752777559071807 GO:0034061 DNA polymerase activity 5/1833 35/18639 0.142857142857143 1.45265372924947 0.257789135354195 0.752777559071807 GO:0004706 JUN kinase kinase kinase activity 3/1833 18/18639 0.166666666666667 1.69476268412439 0.257827983852455 0.752777559071807 GO:0008308 voltage-gated monoatomic anion channel activity 3/1833 18/18639 0.166666666666667 1.69476268412439 0.257827983852455 0.752777559071807 GO:0070064 proline-rich region binding 3/1833 18/18639 0.166666666666667 1.69476268412439 0.257827983852455 0.752777559071807 GO:0003954 NADH dehydrogenase activity 6/1833 44/18639 0.136363636363636 1.38662401428359 0.261554059787534 0.761683269717186 GO:0034212 protein N-acetyltransferase activity 7/1833 53/18639 0.132075471698113 1.34301948553253 0.26275126035602 0.763197604178439 GO:0019210 kinase inhibitor activity 11/1833 90/18639 0.122222222222222 1.24282596835788 0.268900173929102 0.768051146004454 GO:0008266 poly(U) RNA binding 4/1833 27/18639 0.148148148148148 1.50645571922168 0.27175342065041 0.768051146004454 GO:0035255 ionotropic glutamate receptor binding 4/1833 27/18639 0.148148148148148 1.50645571922168 0.27175342065041 0.768051146004454 GO:0033192 calmodulin-dependent protein phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0140791 histone H2AXS140 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:1990439 MAP kinase serine/threonine phosphatase activity 10/1833 81/18639 0.123456790123457 1.25537976601806 0.271918728709651 0.768051146004454 GO:0008168 methyltransferase activity 23/1833 204/18639 0.112745098039216 1.14645710984885 0.275245347042521 0.775503765292303 GO:0016409 palmitoyltransferase activity 5/1833 36/18639 0.138888888888889 1.41230223677032 0.277255588810537 0.777281215396705 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/1833 36/18639 0.138888888888889 1.41230223677032 0.277255588810537 0.777281215396705 GO:0051287 NAD binding 7/1833 54/18639 0.12962962962963 1.31814875431897 0.278509153328654 0.7783056592303 GO:0072341 modified amino acid binding 11/1833 91/18639 0.120879120879121 1.22916854013417 0.280968535544292 0.7783056592303 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 10/1833 82/18639 0.121951219512195 1.24007025667638 0.284728057489049 0.7783056592303 GO:0033549 MAP kinase phosphatase activity 10/1833 82/18639 0.121951219512195 1.24007025667638 0.284728057489049 0.7783056592303 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/1833 19/18639 0.157894736842105 1.60556464811784 0.285609223486085 0.7783056592303 GO:0031420 alkali metal ion binding 3/1833 19/18639 0.157894736842105 1.60556464811784 0.285609223486085 0.7783056592303 GO:0097001 ceramide binding 3/1833 19/18639 0.157894736842105 1.60556464811784 0.285609223486085 0.7783056592303 GO:0120227 acyl-CoA binding 3/1833 19/18639 0.157894736842105 1.60556464811784 0.285609223486085 0.7783056592303 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 19/1833 167/18639 0.11377245508982 1.15690386820467 0.285613988555066 0.7783056592303 GO:0140101 catalytic activity, acting on a tRNA 16/1833 139/18639 0.115107913669065 1.17048358040245 0.290967818772418 0.7783056592303 GO:0046625 sphingolipid binding 4/1833 28/18639 0.142857142857143 1.45265372924947 0.294574756432157 0.7783056592303 GO:0141052 histone H3 demethylase activity 4/1833 28/18639 0.142857142857143 1.45265372924947 0.294574756432157 0.7783056592303 GO:0000099 sulfur amino acid transmembrane transporter activity 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0008432 JUN kinase binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0008526 phosphatidylinositol transfer activity 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0034511 U3 snoRNA binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0034713 type I transforming growth factor beta receptor binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0045294 alpha-catenin binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0048407 platelet-derived growth factor binding 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0140537 transcription regulator activator activity 2/1833 11/18639 0.181818181818182 1.84883201904479 0.29557659463227 0.7783056592303 GO:0022829 wide pore channel activity 5/1833 37/18639 0.135135135135135 1.3741319060468 0.297003397030793 0.778425182450473 GO:0042805 actinin binding 5/1833 37/18639 0.135135135135135 1.3741319060468 0.297003397030793 0.778425182450473 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/1833 83/18639 0.120481927710843 1.22512965117426 0.2977031171085 0.77844875401689 GO:0004540 RNA nuclease activity 14/1833 121/18639 0.115702479338843 1.17652946666486 0.301255302776815 0.785913718123775 GO:0048029 monosaccharide binding 9/1833 74/18639 0.121621621621622 1.23671871544212 0.302181506396031 0.786509371150871 GO:0017018 myosin phosphatase activity 10/1833 84/18639 0.119047619047619 1.21054477437456 0.310826481319987 0.805056325010546 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 14/1833 122/18639 0.114754098360656 1.16688578251187 0.312113952979302 0.805056325010546 GO:0010851 cyclase regulator activity 3/1833 20/18639 0.15 1.52528641571195 0.313607243501009 0.805056325010546 GO:0061608 nuclear import signal receptor activity 3/1833 20/18639 0.15 1.52528641571195 0.313607243501009 0.805056325010546 GO:0043495 protein-membrane adaptor activity 6/1833 47/18639 0.127659574468085 1.29811609847825 0.314307704529406 0.805056325010546 GO:0061733 protein-lysine-acetyltransferase activity 6/1833 47/18639 0.127659574468085 1.29811609847825 0.314307704529406 0.805056325010546 GO:0140938 histone H3 methyltransferase activity 6/1833 47/18639 0.127659574468085 1.29811609847825 0.314307704529406 0.805056325010546 GO:0043531 ADP binding 5/1833 38/18639 0.131578947368421 1.3379705400982 0.316969057611771 0.808038007428798 GO:0003785 actin monomer binding 4/1833 29/18639 0.137931034482759 1.40256222134432 0.317622748261719 0.808038007428798 GO:0016417 S-acyltransferase activity 4/1833 29/18639 0.137931034482759 1.40256222134432 0.317622748261719 0.808038007428798 GO:0020037 heme binding 16/1833 142/18639 0.112676056338028 1.14575505405592 0.321179458951542 0.815246059095467 GO:0016504 peptidase activator activity 7/1833 57/18639 0.12280701754386 1.24877250409165 0.327016504267895 0.816759043576224 GO:0098631 cell adhesion mediator activity 9/1833 76/18639 0.118421052631579 1.20417348608838 0.330322501556215 0.816759043576224 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0003995 acyl-CoA dehydrogenase activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0004526 ribonuclease P activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0005095 GTPase inhibitor activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0005165 neurotrophin receptor binding 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0010853 cyclase activator activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0017166 vinculin binding 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0035197 siRNA binding 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0035497 cAMP response element binding 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0070008 serine-type exopeptidase activity 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0070410 co-SMAD binding 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/1833 12/18639 0.166666666666667 1.69476268412439 0.333371038194377 0.816759043576224 GO:0008173 RNA methyltransferase activity 8/1833 67/18639 0.119402985074627 1.21415834086523 0.336793585432141 0.822754700783315 GO:0001968 fibronectin binding 4/1833 30/18639 0.133333333333333 1.35581014729951 0.340803590190923 0.822754700783315 GO:0008187 poly-pyrimidine tract binding 4/1833 30/18639 0.133333333333333 1.35581014729951 0.340803590190923 0.822754700783315 GO:0015215 nucleotide transmembrane transporter activity 4/1833 30/18639 0.133333333333333 1.35581014729951 0.340803590190923 0.822754700783315 GO:0032452 histone demethylase activity 4/1833 30/18639 0.133333333333333 1.35581014729951 0.340803590190923 0.822754700783315 GO:0046982 protein heterodimerization activity 39/1833 369/18639 0.105691056910569 1.0747275557862 0.341027872609806 0.822754700783315 GO:0019200 carbohydrate kinase activity 3/1833 21/18639 0.142857142857143 1.45265372924947 0.341658562525813 0.822754700783315 GO:0070182 DNA polymerase binding 3/1833 21/18639 0.142857142857143 1.45265372924947 0.341658562525813 0.822754700783315 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/1833 58/18639 0.120689655172414 1.22724194367628 0.343485489652234 0.82539050498522 GO:0001222 transcription corepressor binding 6/1833 49/18639 0.122448979591837 1.24513176792812 0.350360299939556 0.830234858117915 GO:0035254 glutamate receptor binding 6/1833 49/18639 0.122448979591837 1.24513176792812 0.350360299939556 0.830234858117915 GO:0030331 nuclear estrogen receptor binding 5/1833 40/18639 0.125 1.27107201309329 0.357308350467672 0.830234858117915 GO:0032451 demethylase activity 5/1833 40/18639 0.125 1.27107201309329 0.357308350467672 0.830234858117915 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1833 40/18639 0.125 1.27107201309329 0.357308350467672 0.830234858117915 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/1833 31/18639 0.129032258064516 1.3120743360963 0.364028584522941 0.830234858117915 GO:0140457 protein demethylase activity 4/1833 31/18639 0.129032258064516 1.3120743360963 0.364028584522941 0.830234858117915 GO:0004197 cysteine-type endopeptidase activity 10/1833 88/18639 0.113636363636364 1.15552001190299 0.364450821005527 0.830234858117915 GO:0016279 protein-lysine N-methyltransferase activity 8/1833 69/18639 0.115942028985507 1.17896534547783 0.367457797191099 0.830234858117915 GO:0019783 ubiquitin-like protein peptidase activity 14/1833 127/18639 0.110236220472441 1.12094539737361 0.367726844488395 0.830234858117915 GO:0031683 G-protein beta/gamma-subunit complex binding 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0032931 histone H3K56 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0043992 histone H3K9 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0043993 histone H3K18 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0043994 histone H3K23 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0043999 histone H2AK5 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044012 histone H2AK9 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044014 histone H2BK5 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044015 histone H2BK12 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044016 histone H3K4 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044017 histone H3K27 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0044018 histone H3K36 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0046972 histone H4K16 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0061133 endopeptidase activator activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0140908 histone H3K122 acetyltransferase activity 3/1833 22/18639 0.136363636363636 1.38662401428359 0.369615198773579 0.830234858117915 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0009982 pseudouridine synthase activity 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0030955 potassium ion binding 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0031432 titin binding 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0043560 insulin receptor substrate binding 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0046974 histone H3K9 methyltransferase activity 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0046975 histone H3K36 methyltransferase activity 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0097157 pre-mRNA intronic binding 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0140852 histone ubiquitin ligase activity 2/1833 13/18639 0.153846153846154 1.56439632380713 0.370548477048191 0.830234858117915 GO:0033293 monocarboxylic acid binding 9/1833 79/18639 0.113924050632911 1.15844537902173 0.373311381858821 0.834765728878751 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/1833 60/18639 0.116666666666667 1.18633387888707 0.376676623823677 0.835982823639172 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/1833 41/18639 0.121951219512195 1.24007025667638 0.377564558325057 0.835982823639172 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/1833 41/18639 0.121951219512195 1.24007025667638 0.377564558325057 0.835982823639172 GO:0017080 sodium channel regulator activity 5/1833 41/18639 0.121951219512195 1.24007025667638 0.377564558325057 0.835982823639172 GO:0042169 SH2 domain binding 5/1833 41/18639 0.121951219512195 1.24007025667638 0.377564558325057 0.835982823639172 GO:0016278 lysine N-methyltransferase activity 8/1833 70/18639 0.114285714285714 1.16212298339958 0.382883978553032 0.846098517312289 GO:0008378 galactosyltransferase activity 4/1833 32/18639 0.125 1.27107201309329 0.387214575142958 0.850664378530437 GO:0043425 bHLH transcription factor binding 4/1833 32/18639 0.125 1.27107201309329 0.387214575142958 0.850664378530437 GO:0140142 nucleocytoplasmic carrier activity 4/1833 32/18639 0.125 1.27107201309329 0.387214575142958 0.850664378530437 GO:0035591 signaling adaptor activity 14/1833 129/18639 0.108527131782946 1.10356639896472 0.390402192174383 0.851344867374185 GO:0070851 growth factor receptor binding 15/1833 139/18639 0.107913669064748 1.0973283566273 0.392457971233535 0.851344867374185 GO:0016836 hydro-lyase activity 7/1833 61/18639 0.114754098360656 1.16688578251187 0.39333541678437 0.851344867374185 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0005158 insulin receptor binding 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0005283 amino acid:sodium symporter activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0017134 fibroblast growth factor binding 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0044013 histone H2B acetyltransferase activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0071617 lysophospholipid acyltransferase activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0099186 structural constituent of postsynapse 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0140102 catalytic activity, acting on a rRNA 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/1833 23/18639 0.130434782608696 1.32633601366256 0.397344631977659 0.851344867374185 GO:0004705 JUN kinase activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0005161 platelet-derived growth factor receptor binding 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0005313 L-glutamate transmembrane transporter activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0005545 1-phosphatidylinositol binding 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0008474 palmitoyl-(protein) hydrolase activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0008494 translation activator activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0032454 histone H3K9 demethylase activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0044548 S100 protein binding 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0098599 palmitoyl hydrolase activity 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:1990825 sequence-specific mRNA binding 2/1833 14/18639 0.142857142857143 1.45265372924947 0.406864809558961 0.853885736262475 GO:0008200 ion channel inhibitor activity 5/1833 43/18639 0.116279069767442 1.18239257031934 0.417975846833738 0.875573939371046 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/1833 53/18639 0.113207547169811 1.15115955902788 0.423055693190924 0.881528779597919 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/1833 132/18639 0.106060606060606 1.07848534444279 0.424628107477162 0.881528779597919 GO:0004622 lysophospholipase activity 3/1833 24/18639 0.125 1.27107201309329 0.424729482982848 0.881528779597919 GO:0043998 histone H2A acetyltransferase activity 3/1833 24/18639 0.125 1.27107201309329 0.424729482982848 0.881528779597919 GO:0140612 DNA damage sensor activity 3/1833 24/18639 0.125 1.27107201309329 0.424729482982848 0.881528779597919 GO:0046906 tetrapyrrole binding 16/1833 152/18639 0.105263157894737 1.07037643207856 0.426143468734204 0.88283766408722 GO:0008175 tRNA methyltransferase activity 4/1833 34/18639 0.117647058823529 1.19630307114663 0.433166326686783 0.892465173996351 GO:0019825 oxygen binding 4/1833 34/18639 0.117647058823529 1.19630307114663 0.433166326686783 0.892465173996351 GO:0030332 cyclin binding 4/1833 34/18639 0.117647058823529 1.19630307114663 0.433166326686783 0.892465173996351 GO:0016248 channel inhibitor activity 5/1833 44/18639 0.113636363636364 1.15552001190299 0.438029922096072 0.899198036798312 GO:0016790 thiolester hydrolase activity 5/1833 44/18639 0.113636363636364 1.15552001190299 0.438029922096072 0.899198036798312 GO:0016846 carbon-sulfur lyase activity 2/1833 15/18639 0.133333333333333 1.35581014729951 0.442129862050866 0.899423022619722 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/1833 15/18639 0.133333333333333 1.35581014729951 0.442129862050866 0.899423022619722 GO:0031005 filamin binding 2/1833 15/18639 0.133333333333333 1.35581014729951 0.442129862050866 0.899423022619722 GO:0051371 muscle alpha-actinin binding 2/1833 15/18639 0.133333333333333 1.35581014729951 0.442129862050866 0.899423022619722 GO:0140161 monocarboxylate:sodium symporter activity 2/1833 15/18639 0.133333333333333 1.35581014729951 0.442129862050866 0.899423022619722 GO:0004536 DNA nuclease activity 7/1833 64/18639 0.109375 1.11218801145663 0.443203489448584 0.899982581276675 GO:0051117 ATPase binding 9/1833 84/18639 0.107142857142857 1.08949029693711 0.445656385697727 0.903150884949496 GO:0016410 N-acyltransferase activity 10/1833 94/18639 0.106382978723404 1.08176341539854 0.446366497707959 0.903150884949496 GO:0008139 nuclear localization sequence binding 3/1833 25/18639 0.12 1.22022913256956 0.451666980550622 0.905744994805251 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/1833 25/18639 0.12 1.22022913256956 0.451666980550622 0.905744994805251 GO:0017056 structural constituent of nuclear pore 3/1833 25/18639 0.12 1.22022913256956 0.451666980550622 0.905744994805251 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/1833 25/18639 0.12 1.22022913256956 0.451666980550622 0.905744994805251 GO:0019707 protein-cysteine S-acyltransferase activity 3/1833 25/18639 0.12 1.22022913256956 0.451666980550622 0.905744994805251 GO:0043015 gamma-tubulin binding 4/1833 35/18639 0.114285714285714 1.16212298339958 0.45579564169744 0.912400867127912 GO:0004715 non-membrane spanning protein tyrosine kinase activity 5/1833 45/18639 0.111111111111111 1.12984178941626 0.457920825452668 0.913410212894083 GO:0141110 transporter inhibitor activity 5/1833 45/18639 0.111111111111111 1.12984178941626 0.457920825452668 0.913410212894083 GO:0101005 deubiquitinase activity 12/1833 115/18639 0.104347826086957 1.06106881093005 0.45954133806765 0.915023123678873 GO:0002020 protease binding 14/1833 136/18639 0.102941176470588 1.0467651872533 0.470255430936784 0.925743888806106 GO:0003688 DNA replication origin binding 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0004707 MAP kinase activity 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0004708 MAP kinase kinase activity 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0005159 insulin-like growth factor receptor binding 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0005521 lamin binding 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0008142 oxysterol binding 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0008296 3'-5'-DNA exonuclease activity 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0015378 sodium:chloride symporter activity 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1833 16/18639 0.125 1.27107201309329 0.476199152050898 0.925743888806106 GO:0030276 clathrin binding 5/1833 46/18639 0.108695652173913 1.10528001138547 0.477606024002753 0.925743888806106 GO:0004529 DNA exonuclease activity 3/1833 26/18639 0.115384615384615 1.17329724285534 0.478068272657634 0.925743888806106 GO:0005160 transforming growth factor beta receptor binding 3/1833 26/18639 0.115384615384615 1.17329724285534 0.478068272657634 0.925743888806106 GO:0070006 metalloaminopeptidase activity 3/1833 26/18639 0.115384615384615 1.17329724285534 0.478068272657634 0.925743888806106 GO:0120014 phospholipid transfer activity 3/1833 26/18639 0.115384615384615 1.17329724285534 0.478068272657634 0.925743888806106 GO:0022853 active monoatomic ion transmembrane transporter activity 12/1833 118/18639 0.101694915254237 1.03409248522844 0.496362719975722 0.959197226450531 GO:0001784 phosphotyrosine residue binding 5/1833 47/18639 0.106382978723404 1.08176341539854 0.497046300130532 0.959197226450531 GO:0005085 guanyl-nucleotide exchange factor activity 23/1833 230/18639 0.1 1.01685761047463 0.498872374783275 0.961075498086754 GO:0008170 N-methyltransferase activity 10/1833 98/18639 0.102040816326531 1.03760980660677 0.500429378386802 0.96242987959373 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/1833 88/18639 0.102272727272727 1.03996801071269 0.502778142262852 0.965299772283193 GO:0005092 GDP-dissociation inhibitor activity 2/1833 17/18639 0.117647058823529 1.19630307114663 0.508966748689064 0.972212755546737 GO:0017110 nucleoside diphosphate phosphatase activity 2/1833 17/18639 0.117647058823529 1.19630307114663 0.508966748689064 0.972212755546737 GO:0070402 NADPH binding 2/1833 17/18639 0.117647058823529 1.19630307114663 0.508966748689064 0.972212755546737 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1833 48/18639 0.104166666666667 1.05922667757774 0.516205764920697 0.981052102977447 GO:0032266 phosphatidylinositol-3-phosphate binding 5/1833 48/18639 0.104166666666667 1.05922667757774 0.516205764920697 0.981052102977447 GO:0140693 molecular condensate scaffold activity 5/1833 48/18639 0.104166666666667 1.05922667757774 0.516205764920697 0.981052102977447 GO:0005109 frizzled binding 4/1833 38/18639 0.105263157894737 1.07037643207856 0.521606644000035 0.989647622538786 GO:0046875 ephrin receptor binding 3/1833 28/18639 0.107142857142857 1.08949029693711 0.528971573885702 0.998898625226039 GO:0051393 alpha-actinin binding 3/1833 28/18639 0.107142857142857 1.08949029693711 0.528971573885702 0.998898625226039 GO:0036002 pre-mRNA binding 6/1833 59/18639 0.101694915254237 1.03409248522844 0.5291415077728 0.998898625226039 GO:0000400 four-way junction DNA binding 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0008409 5'-3' exonuclease activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0008525 phosphatidylcholine transporter activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0015172 acidic amino acid transmembrane transporter activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0015373 monoatomic anion:sodium symporter activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0016854 racemase and epimerase activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0017075 syntaxin-1 binding 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0017128 phospholipid scramblase activity 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0050811 GABA receptor binding 2/1833 18/18639 0.111111111111111 1.12984178941626 0.54035909429364 0.999999999999956 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1833 60/18639 0.1 1.01685761047463 0.546082050433814 0.999999999999956 GO:0030971 receptor tyrosine kinase binding 8/1833 81/18639 0.0987654320987654 1.00430381281445 0.549574565636129 0.999999999999956 GO:0061134 peptidase regulator activity 22/1833 226/18639 0.0973451327433628 0.989861390727518 0.553324308460174 0.999999999999956 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1833 29/18639 0.103448275862069 1.05192166600824 0.553357976842316 0.999999999999956 GO:0005416 amino acid:monoatomic cation symporter activity 3/1833 29/18639 0.103448275862069 1.05192166600824 0.553357976842316 0.999999999999956 GO:0035250 UDP-galactosyltransferase activity 3/1833 29/18639 0.103448275862069 1.05192166600824 0.553357976842316 0.999999999999956 GO:0097472 cyclin-dependent protein kinase activity 3/1833 29/18639 0.103448275862069 1.05192166600824 0.553357976842316 0.999999999999956 GO:0015605 organophosphate ester transmembrane transporter activity 5/1833 50/18639 0.1 1.01685761047463 0.55355521507673 0.999999999999956 GO:0004177 aminopeptidase activity 4/1833 40/18639 0.1 1.01685761047463 0.5632926095926 0.999999999999956 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1833 40/18639 0.1 1.01685761047463 0.5632926095926 0.999999999999956 GO:0004722 protein serine/threonine phosphatase activity 10/1833 103/18639 0.0970873786407767 0.98724039851906 0.565777156244277 0.999999999999956 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0008301 DNA binding, bending 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0034987 immunoglobulin receptor binding 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0042800 histone H3K4 methyltransferase activity 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0043395 heparan sulfate proteoglycan binding 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0050145 nucleoside monophosphate kinase activity 2/1833 19/18639 0.105263157894737 1.07037643207856 0.570329667329823 0.999999999999956 GO:0016830 carbon-carbon lyase activity 5/1833 51/18639 0.0980392156862745 0.996919225955521 0.571689774639941 0.999999999999956 GO:0001965 G-protein alpha-subunit binding 3/1833 30/18639 0.1 1.01685761047463 0.576975130914693 0.999999999999956 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1833 30/18639 0.1 1.01685761047463 0.576975130914693 0.999999999999956 GO:0098918 structural constituent of synapse 3/1833 30/18639 0.1 1.01685761047463 0.576975130914693 0.999999999999956 GO:0016874 ligase activity 16/1833 167/18639 0.0958083832335329 0.974234836382881 0.582380458598632 0.999999999999956 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1833 41/18639 0.0975609756097561 0.992056205341104 0.58337131783774 0.999999999999956 GO:0140789 histone phosphatase activity 13/1833 136/18639 0.0955882352941176 0.971996245306633 0.585581694799393 0.999999999999956 GO:0031267 small GTPase binding 27/1833 283/18639 0.0954063604240283 0.970146836848589 0.596037287031221 0.999999999999956 GO:0016505 peptidase activator activity involved in apoptotic process 2/1833 20/18639 0.1 1.01685761047463 0.59885438108858 0.999999999999956 GO:0031418 L-ascorbic acid binding 2/1833 20/18639 0.1 1.01685761047463 0.59885438108858 0.999999999999956 GO:0052745 inositol phosphate phosphatase activity 2/1833 20/18639 0.1 1.01685761047463 0.59885438108858 0.999999999999956 GO:0140939 histone H4 methyltransferase activity 2/1833 20/18639 0.1 1.01685761047463 0.59885438108858 0.999999999999956 GO:0070273 phosphatidylinositol-4-phosphate binding 3/1833 31/18639 0.0967741935483871 0.984055752072224 0.599790832313809 0.999999999999956 GO:0003678 DNA helicase activity 7/1833 74/18639 0.0945945945945946 0.96189233423276 0.600589347100938 0.999999999999956 GO:0004520 DNA endonuclease activity 4/1833 42/18639 0.0952380952380952 0.968435819499649 0.602904677679874 0.999999999999956 GO:0048487 beta-tubulin binding 4/1833 42/18639 0.0952380952380952 0.968435819499649 0.602904677679874 0.999999999999956 GO:0008013 beta-catenin binding 10/1833 106/18639 0.0943396226415094 0.959299632523237 0.603230649893252 0.999999999999956 GO:1990782 protein tyrosine kinase binding 11/1833 117/18639 0.094017094017094 0.95601997565991 0.608360456066524 0.999999999999956 GO:0140767 enzyme-substrate adaptor activity 13/1833 139/18639 0.0935251798561151 0.951017909076994 0.61789365300887 0.999999999999956 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1833 32/18639 0.09375 0.953304009819967 0.621781479607346 0.999999999999956 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/1833 43/18639 0.0930232558139535 0.945914056255471 0.621871737253836 0.999999999999956 GO:0050661 NADP binding 5/1833 54/18639 0.0925925925925926 0.941534824513548 0.623665415089491 0.999999999999956 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1833 21/18639 0.0952380952380952 0.968435819499649 0.625927625147819 0.999999999999956 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1833 21/18639 0.0952380952380952 0.968435819499649 0.625927625147819 0.999999999999956 GO:0035613 RNA stem-loop binding 2/1833 21/18639 0.0952380952380952 0.968435819499649 0.625927625147819 0.999999999999956 GO:0140312 cargo adaptor activity 2/1833 21/18639 0.0952380952380952 0.968435819499649 0.625927625147819 0.999999999999956 GO:0001217 DNA-binding transcription repressor activity 26/1833 278/18639 0.0935251798561151 0.951017909076994 0.636872942385462 0.999999999999956 GO:0001223 transcription coactivator binding 4/1833 44/18639 0.0909090909090909 0.924416009522393 0.640255918769613 0.999999999999956 GO:0043014 alpha-tubulin binding 4/1833 44/18639 0.0909090909090909 0.924416009522393 0.640255918769613 0.999999999999956 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/1833 268/18639 0.0932835820895522 0.948561203800963 0.640607296302873 0.999999999999956 GO:0019239 deaminase activity 3/1833 33/18639 0.0909090909090909 0.924416009522393 0.642931202594389 0.999999999999956 GO:0030296 protein tyrosine kinase activator activity 3/1833 33/18639 0.0909090909090909 0.924416009522393 0.642931202594389 0.999999999999956 GO:0071889 14-3-3 protein binding 3/1833 33/18639 0.0909090909090909 0.924416009522393 0.642931202594389 0.999999999999956 GO:0061135 endopeptidase regulator activity 17/1833 184/18639 0.0923913043478261 0.939488009677649 0.643797161646752 0.999999999999956 GO:0000182 rDNA binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0004955 prostaglandin receptor activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0005131 growth hormone receptor binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0005345 purine nucleobase transmembrane transporter activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0008239 dipeptidyl-peptidase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0015279 store-operated calcium channel activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0019911 structural constituent of myelin sheath 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0032052 bile acid binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0032356 oxidized DNA binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0035256 G protein-coupled glutamate receptor binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0042166 acetylcholine binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0043422 protein kinase B binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0140940 histone H2A methyltransferase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0140999 histone H3K4 trimethyltransferase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:1905394 retromer complex binding 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:1990259 histone H2AQ104 methyltransferase activity 1/1833 10/18639 0.1 1.01685761047463 0.644938888536069 0.999999999999956 GO:0008649 rRNA methyltransferase activity 2/1833 22/18639 0.0909090909090909 0.924416009522393 0.651558867785243 0.999999999999956 GO:0015377 chloride:monoatomic cation symporter activity 2/1833 22/18639 0.0909090909090909 0.924416009522393 0.651558867785243 0.999999999999956 GO:0050321 tau-protein kinase activity 2/1833 22/18639 0.0909090909090909 0.924416009522393 0.651558867785243 0.999999999999956 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/1833 67/18639 0.0895522388059701 0.910618755648924 0.65592512030971 0.999999999999956 GO:0046915 transition metal ion transmembrane transporter activity 4/1833 45/18639 0.0888888888888889 0.903873431533006 0.65804470836151 0.999999999999956 GO:0005506 iron ion binding 14/1833 154/18639 0.0909090909090909 0.924416009522393 0.661819317231703 0.999999999999956 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1833 34/18639 0.0882352941176471 0.897227303359969 0.663231029295124 0.999999999999956 GO:0051427 hormone receptor binding 3/1833 34/18639 0.0882352941176471 0.897227303359969 0.663231029295124 0.999999999999956 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1833 57/18639 0.087719298245614 0.891980360065466 0.671667059396746 0.999999999999956 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1833 46/18639 0.0869565217391304 0.884224009108375 0.675229344967106 0.999999999999956 GO:0031681 G-protein beta-subunit binding 2/1833 23/18639 0.0869565217391304 0.884224009108375 0.675769747385965 0.999999999999956 GO:0140103 catalytic activity, acting on a glycoprotein 2/1833 23/18639 0.0869565217391304 0.884224009108375 0.675769747385965 0.999999999999956 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0004954 prostanoid receptor activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0008199 ferric iron binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0015205 nucleobase transmembrane transporter activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0019107 myristoyltransferase activity 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0032050 clathrin heavy chain binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0032794 GTPase activating protein binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0034056 estrogen response element binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0042608 T cell receptor binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0048185 activin binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0140031 phosphorylation-dependent protein binding 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1833 11/18639 0.0909090909090909 0.924416009522393 0.679875117926448 0.999999999999956 GO:0005343 organic acid:sodium symporter activity 3/1833 35/18639 0.0857142857142857 0.871592237549684 0.682678096882408 0.999999999999956 GO:0016229 steroid dehydrogenase activity 3/1833 35/18639 0.0857142857142857 0.871592237549684 0.682678096882408 0.999999999999956 GO:0017116 single-stranded DNA helicase activity 5/1833 58/18639 0.0862068965517241 0.8766013883402 0.686735110697626 0.999999999999956 GO:0005315 phosphate transmembrane transporter activity 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0030215 semaphorin receptor binding 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0070300 phosphatidic acid binding 2/1833 24/18639 0.0833333333333333 0.847381342062193 0.69859158960443 0.999999999999956 GO:0030414 peptidase inhibitor activity 15/1833 169/18639 0.0887573964497041 0.902536340657957 0.70042879122099 0.999999999999956 GO:0004033 aldo-keto reductase (NADPH) activity 3/1833 36/18639 0.0833333333333333 0.847381342062193 0.701274910389144 0.999999999999956 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/1833 36/18639 0.0833333333333333 0.847381342062193 0.701274910389144 0.999999999999956 GO:0045505 dynein intermediate chain binding 3/1833 36/18639 0.0833333333333333 0.847381342062193 0.701274910389144 0.999999999999956 GO:0035401 histone H3Y41 kinase activity 10/1833 115/18639 0.0869565217391304 0.884224009108375 0.705114579667559 0.999999999999956 GO:0140801 histone H2AXY142 kinase activity 10/1833 115/18639 0.0869565217391304 0.884224009108375 0.705114579667559 0.999999999999956 GO:0051213 dioxygenase activity 8/1833 93/18639 0.0860215053763441 0.874716224064199 0.706142588810448 0.999999999999956 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/1833 48/18639 0.0833333333333333 0.847381342062193 0.707768034383916 0.999999999999956 GO:0000340 RNA 7-methylguanosine cap binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0003720 telomerase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0004032 aldose reductase (NADPH) activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0004126 cytidine deaminase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0004300 enoyl-CoA hydratase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0005049 nuclear export signal receptor activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0005078 MAP-kinase scaffold activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0005436 sodium:phosphate symporter activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0008179 adenylate cyclase binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016273 arginine N-methyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016274 protein-arginine N-methyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016423 tRNA (guanine) methyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016801 hydrolase activity, acting on ether bonds 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016803 ether hydrolase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0016840 carbon-nitrogen lyase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0031543 peptidyl-proline dioxygenase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0034452 dynactin binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0035259 nuclear glucocorticoid receptor binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0036009 protein-glutamine N-methyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0045295 gamma-catenin binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0097371 MDM2/MDM4 family protein binding 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1833 12/18639 0.0833333333333333 0.847381342062193 0.711375488811182 0.999999999999956 GO:0004519 endonuclease activity 11/1833 127/18639 0.0866141732283465 0.880742812222122 0.715146716709522 0.999999999999956 GO:0043394 proteoglycan binding 3/1833 37/18639 0.0810810810810811 0.82447914362808 0.7190286514147 0.999999999999956 GO:0000030 mannosyltransferase activity 2/1833 25/18639 0.08 0.813486088379705 0.720063294739544 0.999999999999956 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1833 25/18639 0.08 0.813486088379705 0.720063294739544 0.999999999999956 GO:0120020 cholesterol transfer activity 2/1833 25/18639 0.08 0.813486088379705 0.720063294739544 0.999999999999956 GO:0004866 endopeptidase inhibitor activity 14/1833 161/18639 0.0869565217391304 0.884224009108375 0.725102533459743 0.999999999999956 GO:0004521 RNA endonuclease activity 6/1833 73/18639 0.0821917808219178 0.8357733784723 0.735743296751861 0.999999999999956 GO:0002161 aminoacyl-tRNA editing activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0003964 RNA-directed DNA polymerase activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0004535 poly(A)-specific ribonuclease activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0005542 folic acid binding 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0019855 calcium channel inhibitor activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0031994 insulin-like growth factor I binding 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0045159 myosin II binding 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0051011 microtubule minus-end binding 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:1901338 catecholamine binding 1/1833 13/18639 0.0769230769230769 0.782198161903563 0.739777739791431 0.999999999999956 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1833 26/18639 0.0769230769230769 0.782198161903563 0.740229546579702 0.999999999999956 GO:0008198 ferrous iron binding 2/1833 26/18639 0.0769230769230769 0.782198161903563 0.740229546579702 0.999999999999956 GO:0050750 low-density lipoprotein particle receptor binding 2/1833 26/18639 0.0769230769230769 0.782198161903563 0.740229546579702 0.999999999999956 GO:0097602 cullin family protein binding 2/1833 26/18639 0.0769230769230769 0.782198161903563 0.740229546579702 0.999999999999956 GO:0015078 proton transmembrane transporter activity 16/1833 185/18639 0.0864864864864865 0.879444419869952 0.742129432895828 0.999999999999956 GO:0003730 mRNA 3'-UTR binding 23/1833 262/18639 0.0877862595419847 0.892661261103684 0.747811496137345 0.999999999999956 GO:0016791 phosphatase activity 24/1833 273/18639 0.0879120879120879 0.893940756461215 0.748924516156421 0.999999999999956 GO:0005507 copper ion binding 5/1833 63/18639 0.0793650793650794 0.807029849583041 0.75490648744347 0.999999999999956 GO:0008234 cysteine-type peptidase activity 16/1833 187/18639 0.0855614973262032 0.870038597197546 0.757155757668393 0.999999999999956 GO:0031406 carboxylic acid binding 16/1833 187/18639 0.0855614973262032 0.870038597197546 0.757155757668393 0.999999999999956 GO:0023026 MHC class II protein complex binding 2/1833 27/18639 0.0740740740740741 0.753227859610838 0.759139299973396 0.999999999999956 GO:0008174 mRNA methyltransferase activity 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0008392 arachidonate epoxygenase activity 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0031404 chloride ion binding 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0042813 Wnt receptor activity 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0043176 amine binding 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:1901612 cardiolipin binding 1/1833 14/18639 0.0714285714285714 0.726326864624737 0.76538642673239 0.999999999999956 GO:0015399 primary active transmembrane transporter activity 14/1833 166/18639 0.0843373493975904 0.857590755821979 0.765415956365076 0.999999999999956 GO:0005080 protein kinase C binding 4/1833 52/18639 0.0769230769230769 0.782198161903563 0.765555963763203 0.999999999999956 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1833 52/18639 0.0769230769230769 0.782198161903563 0.765555963763203 0.999999999999956 GO:0043177 organic acid binding 16/1833 189/18639 0.0846560846560847 0.860831839555244 0.771591562277067 0.999999999999956 GO:0045499 chemorepellent activity 2/1833 28/18639 0.0714285714285714 0.726326864624737 0.776844509672449 0.999999999999956 GO:0051019 mitogen-activated protein kinase binding 2/1833 28/18639 0.0714285714285714 0.726326864624737 0.776844509672449 0.999999999999956 GO:0051119 sugar transmembrane transporter activity 2/1833 28/18639 0.0714285714285714 0.726326864624737 0.776844509672449 0.999999999999956 GO:0051959 dynein light intermediate chain binding 2/1833 28/18639 0.0714285714285714 0.726326864624737 0.776844509672449 0.999999999999956 GO:0004812 aminoacyl-tRNA ligase activity 3/1833 41/18639 0.0731707317073171 0.744042154005828 0.781885758462887 0.999999999999956 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/1833 41/18639 0.0731707317073171 0.744042154005828 0.781885758462887 0.999999999999956 GO:0004089 carbonate dehydratase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0004953 icosanoid receptor activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0017081 chloride channel regulator activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0033130 acetylcholine receptor binding 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0047372 monoacylglycerol lipase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0048531 beta-1,3-galactosyltransferase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0050700 CARD domain binding 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0050780 dopamine receptor binding 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0061578 K63-linked deubiquitinase activity 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0120283 protein serine/threonine kinase binding 1/1833 15/18639 0.0666666666666667 0.677905073649754 0.788476181352499 0.999999999999956 GO:0015485 cholesterol binding 4/1833 54/18639 0.0740740740740741 0.753227859610838 0.79090687565785 0.999999999999956 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 15/1833 181/18639 0.0828729281767956 0.842699677188921 0.793228273710428 0.999999999999956 GO:0043236 laminin binding 2/1833 29/18639 0.0689655172413793 0.70128111067216 0.793399067659867 0.999999999999956 GO:0042277 peptide binding 21/1833 249/18639 0.0843373493975904 0.857590755821979 0.801525940157224 0.999999999999956 GO:0140313 molecular sequestering activity 4/1833 55/18639 0.0727272727272727 0.739532807617914 0.802732975826269 0.999999999999956 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1833 43/18639 0.0697674418604651 0.709435542191604 0.808687168656776 0.999999999999956 GO:0031624 ubiquitin conjugating enzyme binding 2/1833 30/18639 0.0666666666666667 0.677905073649754 0.808857920284522 0.999999999999956 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0005149 interleukin-1 receptor binding 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0008391 arachidonate monooxygenase activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0016722 oxidoreductase activity, acting on metal ions 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0022841 potassium ion leak channel activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0022858 alanine transmembrane transporter activity 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1833 16/18639 0.0625 0.635536006546645 0.809294649972606 0.999999999999956 GO:0003777 microtubule motor activity 5/1833 68/18639 0.0735294117647059 0.747689419466641 0.811326144462783 0.999999999999956 GO:0005548 phospholipid transporter activity 5/1833 68/18639 0.0735294117647059 0.747689419466641 0.811326144462783 0.999999999999956 GO:0043178 alcohol binding 7/1833 92/18639 0.0760869565217391 0.773696007969829 0.812202677320702 0.999999999999956 GO:0005164 tumor necrosis factor receptor binding 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0016411 acylglycerol O-acyltransferase activity 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0016878 acid-thiol ligase activity 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0017147 Wnt-protein binding 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0070325 lipoprotein particle receptor binding 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0072349 modified amino acid transmembrane transporter activity 2/1833 31/18639 0.0645161290322581 0.656037168048149 0.823276340144571 0.999999999999956 GO:0004721 phosphoprotein phosphatase activity 14/1833 175/18639 0.08 0.813486088379705 0.827384882266952 0.999999999999956 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0015278 intracellularly gated calcium channel activity 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0016805 dipeptidase activity 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0030169 low-density lipoprotein particle binding 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0030548 acetylcholine receptor regulator activity 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0045236 CXCR chemokine receptor binding 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0046965 nuclear retinoid X receptor binding 1/1833 17/18639 0.0588235294117647 0.598151535573313 0.828065143802828 0.999999999999956 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/1833 70/18639 0.0714285714285714 0.726326864624737 0.830779621087147 0.999999999999956 GO:0120015 sterol transfer activity 2/1833 32/18639 0.0625 0.635536006546645 0.836709330847053 0.999999999999956 GO:0004867 serine-type endopeptidase inhibitor activity 7/1833 95/18639 0.0736842105263158 0.749263502454992 0.837166849885839 0.999999999999956 GO:0001540 amyloid-beta binding 6/1833 83/18639 0.072289156626506 0.735077790704553 0.83769245984716 0.999999999999956 GO:0004180 carboxypeptidase activity 3/1833 46/18639 0.0652173913043478 0.663168006831282 0.843634852790027 0.999999999999956 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1833 46/18639 0.0652173913043478 0.663168006831282 0.843634852790027 0.999999999999956 GO:0015459 potassium channel regulator activity 4/1833 59/18639 0.0677966101694915 0.689394990152293 0.844696723013445 0.999999999999956 GO:0070888 E-box binding 4/1833 59/18639 0.0677966101694915 0.689394990152293 0.844696723013445 0.999999999999956 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0031690 adrenergic receptor binding 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0035615 clathrin adaptor activity 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0099602 neurotransmitter receptor regulator activity 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:1901611 phosphatidylglycerol binding 1/1833 18/18639 0.0555555555555556 0.564920894708129 0.844989029068074 0.999999999999956 GO:0030695 GTPase regulator activity 42/1833 489/18639 0.0858895705521472 0.873374634763488 0.845003592050006 0.999999999999956 GO:0004843 cysteine-type deubiquitinase activity 8/1833 108/18639 0.0740740740740741 0.753227859610838 0.845014468975601 0.999999999999956 GO:0060589 nucleoside-triphosphatase regulator activity 42/1833 490/18639 0.0857142857142857 0.871592237549684 0.848484722851985 0.999999999999956 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1833 33/18639 0.0606060606060606 0.616277339681595 0.849211145573031 0.999999999999956 GO:0140311 protein sequestering activity 2/1833 33/18639 0.0606060606060606 0.616277339681595 0.849211145573031 0.999999999999956 GO:0061749 forked DNA-dependent helicase activity 3/1833 47/18639 0.0638297872340425 0.649058049239127 0.853986921485121 0.999999999999956 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/1833 47/18639 0.0638297872340425 0.649058049239127 0.853986921485121 0.999999999999956 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/1833 122/18639 0.0737704918032787 0.750140860186204 0.85902514577467 0.999999999999956 GO:0004725 protein tyrosine phosphatase activity 7/1833 98/18639 0.0714285714285714 0.726326864624737 0.859415207842689 0.999999999999956 GO:0005520 insulin-like growth factor binding 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0008574 plus-end-directed microtubule motor activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0015245 fatty acid transmembrane transporter activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0022840 leak channel activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0022842 narrow pore channel activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0046624 sphingolipid transporter activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:1990380 K48-linked deubiquitinase activity 1/1833 19/18639 0.0526315789473684 0.53518821603928 0.860247882497977 0.999999999999956 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1833 34/18639 0.0588235294117647 0.598151535573313 0.8608349028404 0.999999999999956 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1833 34/18639 0.0588235294117647 0.598151535573313 0.8608349028404 0.999999999999956 GO:0016831 carboxy-lyase activity 2/1833 34/18639 0.0588235294117647 0.598151535573313 0.8608349028404 0.999999999999956 GO:0090482 vitamin transmembrane transporter activity 2/1833 34/18639 0.0588235294117647 0.598151535573313 0.8608349028404 0.999999999999956 GO:0008188 neuropeptide receptor activity 3/1833 48/18639 0.0625 0.635536006546645 0.863734847291868 0.999999999999956 GO:0009378 four-way junction helicase activity 3/1833 48/18639 0.0625 0.635536006546645 0.863734847291868 0.999999999999956 GO:0036121 double-stranded DNA helicase activity 3/1833 48/18639 0.0625 0.635536006546645 0.863734847291868 0.999999999999956 GO:0043138 3'-5' DNA helicase activity 3/1833 48/18639 0.0625 0.635536006546645 0.863734847291868 0.999999999999956 GO:0005126 cytokine receptor binding 22/1833 275/18639 0.08 0.813486088379705 0.872954517930927 0.999999999999956 GO:0001972 retinoic acid binding 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0015464 acetylcholine receptor activity 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0016004 phospholipase activator activity 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0030627 pre-mRNA 5'-splice site binding 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0030742 GTP-dependent protein binding 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:0140664 ATP-dependent DNA damage sensor activity 1/1833 20/18639 0.05 0.508428805237316 0.874005435203735 0.999999999999956 GO:1901682 sulfur compound transmembrane transporter activity 4/1833 63/18639 0.0634920634920635 0.645623879666433 0.87886956431713 0.999999999999956 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/1833 89/18639 0.0674157303370786 0.685521984589639 0.881855500476612 0.999999999999956 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/1833 89/18639 0.0674157303370786 0.685521984589639 0.881855500476612 0.999999999999956 GO:0015171 amino acid transmembrane transporter activity 7/1833 102/18639 0.0686274509803922 0.697843458168865 0.88515508762314 0.999999999999956 GO:0001846 opsonin binding 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0008373 sialyltransferase activity 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0015174 basic amino acid transmembrane transporter activity 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0051010 microtubule plus-end binding 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0051428 peptide hormone receptor binding 1/1833 21/18639 0.0476190476190476 0.484217909749825 0.88640932570653 0.999999999999956 GO:0140793 histone H2AXY142 phosphatase activity 6/1833 90/18639 0.0666666666666667 0.677905073649754 0.888132480106885 0.999999999999956 GO:0005253 monoatomic anion channel activity 7/1833 103/18639 0.0679611650485437 0.691068278963342 0.89093588191904 0.999999999999956 GO:0023023 MHC protein complex binding 2/1833 37/18639 0.0540540540540541 0.54965276241872 0.890946144522023 0.999999999999956 GO:0030280 structural constituent of skin epidermis 2/1833 37/18639 0.0540540540540541 0.54965276241872 0.890946144522023 0.999999999999956 GO:0004713 protein tyrosine kinase activity 10/1833 140/18639 0.0714285714285714 0.726326864624737 0.892421458298044 0.999999999999956 GO:0120013 lipid transfer activity 4/1833 65/18639 0.0615384615384615 0.62575852952285 0.893367300463157 0.999999999999956 GO:0005243 gap junction channel activity 1/1833 22/18639 0.0454545454545455 0.462208004761196 0.897592680845639 0.999999999999956 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1833 22/18639 0.0454545454545455 0.462208004761196 0.897592680845639 0.999999999999956 GO:0000146 microfilament motor activity 2/1833 38/18639 0.0526315789473684 0.53518821603928 0.899557011564106 0.999999999999956 GO:0008235 metalloexopeptidase activity 4/1833 66/18639 0.0606060606060606 0.616277339681595 0.900027997610937 0.999999999999956 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1833 130/18639 0.0692307692307692 0.703978345713207 0.9027251221627 0.999999999999956 GO:0051018 protein kinase A binding 3/1833 53/18639 0.0566037735849057 0.575579779513942 0.904337270852483 0.999999999999956 GO:0050840 extracellular matrix binding 4/1833 67/18639 0.0597014925373134 0.607079170432616 0.906318715798715 0.999999999999956 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1833 23/18639 0.0434782608695652 0.442112004554188 0.907675541457442 0.999999999999956 GO:0004602 glutathione peroxidase activity 1/1833 23/18639 0.0434782608695652 0.442112004554188 0.907675541457442 0.999999999999956 GO:0016493 C-C chemokine receptor activity 1/1833 23/18639 0.0434782608695652 0.442112004554188 0.907675541457442 0.999999999999956 GO:0043274 phospholipase binding 1/1833 23/18639 0.0434782608695652 0.442112004554188 0.907675541457442 0.999999999999956 GO:0016247 channel regulator activity 12/1833 168/18639 0.0714285714285714 0.726326864624737 0.909469460994254 0.999999999999956 GO:0001664 G protein-coupled receptor binding 23/1833 297/18639 0.0774410774410774 0.787465489593149 0.909855293237128 0.999999999999956 GO:0015101 organic cation transmembrane transporter activity 5/1833 81/18639 0.0617283950617284 0.627689883009032 0.910434328925675 0.999999999999956 GO:0030145 manganese ion binding 4/1833 68/18639 0.0588235294117647 0.598151535573313 0.912255751507211 0.999999999999956 GO:0032934 sterol binding 4/1833 68/18639 0.0588235294117647 0.598151535573313 0.912255751507211 0.999999999999956 GO:1901681 sulfur compound binding 21/1833 275/18639 0.0763636363636364 0.77650944799881 0.913068291240834 0.999999999999956 GO:0015144 carbohydrate transmembrane transporter activity 2/1833 40/18639 0.05 0.508428805237316 0.914907436890074 0.999999999999956 GO:0005540 hyaluronic acid binding 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0015149 hexose transmembrane transporter activity 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0015295 solute:proton symporter activity 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0019957 C-C chemokine binding 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0055056 D-glucose transmembrane transporter activity 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0060229 lipase activator activity 1/1833 24/18639 0.0416666666666667 0.423690671031097 0.916766148059747 0.999999999999956 GO:0141108 transporter regulator activity 12/1833 170/18639 0.0705882352941176 0.717781842687975 0.917025221704776 0.999999999999956 GO:0008374 O-acyltransferase activity 3/1833 55/18639 0.0545454545454545 0.554649605713435 0.917256378071987 0.999999999999956 GO:0001727 lipid kinase activity 2/1833 41/18639 0.0487804878048781 0.496028102670552 0.921729061424802 0.999999999999956 GO:0016782 transferase activity, transferring sulphur-containing groups 4/1833 70/18639 0.0571428571428571 0.581061491699789 0.92313239856171 0.999999999999956 GO:0015297 antiporter activity 9/1833 135/18639 0.0666666666666667 0.677905073649754 0.923782892789858 0.999999999999956 GO:0099106 ion channel regulator activity 11/1833 160/18639 0.06875 0.699089607201309 0.924758800751052 0.999999999999956 GO:0001848 complement binding 1/1833 25/18639 0.04 0.406743044189853 0.924962100281423 0.999999999999956 GO:0003707 nuclear steroid receptor activity 1/1833 25/18639 0.04 0.406743044189853 0.924962100281423 0.999999999999956 GO:0005537 D-mannose binding 1/1833 25/18639 0.04 0.406743044189853 0.924962100281423 0.999999999999956 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1833 25/18639 0.04 0.406743044189853 0.924962100281423 0.999999999999956 GO:0047617 fatty acyl-CoA hydrolase activity 1/1833 25/18639 0.04 0.406743044189853 0.924962100281423 0.999999999999956 GO:0042056 chemoattractant activity 2/1833 42/18639 0.0476190476190476 0.484217909749825 0.928032837800655 0.999999999999956 GO:0140299 molecular sensor activity 4/1833 71/18639 0.0563380281690141 0.572877527027962 0.928102921556379 0.999999999999956 GO:0042578 phosphoric ester hydrolase activity 28/1833 363/18639 0.0771349862258953 0.784352977776576 0.931807247537379 0.999999999999956 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0004950 chemokine receptor activity 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0005112 Notch binding 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0015145 monosaccharide transmembrane transporter activity 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0016289 acyl-CoA hydrolase activity 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0030507 spectrin binding 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0034237 protein kinase A regulatory subunit binding 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0052742 phosphatidylinositol kinase activity 1/1833 26/18639 0.0384615384615385 0.391099080951781 0.932351402429491 0.999999999999956 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0005044 scavenger receptor activity 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0005104 fibroblast growth factor receptor binding 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0005385 zinc ion transmembrane transporter activity 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0015252 proton channel activity 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1833 27/18639 0.037037037037037 0.376613929805419 0.93901340637011 0.999999999999956 GO:0008238 exopeptidase activity 6/1833 102/18639 0.0588235294117647 0.598151535573313 0.943807842884826 0.999999999999956 GO:0140303 intramembrane lipid transporter activity 2/1833 45/18639 0.0444444444444444 0.451936715766503 0.944185093605297 0.999999999999956 GO:0005242 inward rectifier potassium channel activity 1/1833 28/18639 0.0357142857142857 0.363163432312368 0.945019661803357 0.999999999999956 GO:0030291 protein serine/threonine kinase inhibitor activity 2/1833 46/18639 0.0434782608695652 0.442112004554188 0.9487555590969 0.999999999999956 GO:0016798 hydrolase activity, acting on glycosyl bonds 8/1833 130/18639 0.0615384615384615 0.62575852952285 0.949030523352054 0.999999999999956 GO:0051861 glycolipid binding 1/1833 29/18639 0.0344827586206897 0.35064055533608 0.950434683022767 0.999999999999956 GO:0099604 ligand-gated calcium channel activity 1/1833 29/18639 0.0344827586206897 0.35064055533608 0.950434683022767 0.999999999999956 GO:0015179 L-amino acid transmembrane transporter activity 3/1833 62/18639 0.0483870967741935 0.492027876036112 0.950896961260601 0.999999999999956 GO:0140359 ABC-type transporter activity 2/1833 47/18639 0.0425531914893617 0.432705366159418 0.952967498546312 0.999999999999956 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/1833 30/18639 0.0333333333333333 0.338952536824877 0.955316640358569 0.999999999999956 GO:0016769 transferase activity, transferring nitrogenous groups 1/1833 30/18639 0.0333333333333333 0.338952536824877 0.955316640358569 0.999999999999956 GO:0048019 receptor antagonist activity 1/1833 30/18639 0.0333333333333333 0.338952536824877 0.955316640358569 0.999999999999956 GO:0070566 adenylyltransferase activity 1/1833 30/18639 0.0333333333333333 0.338952536824877 0.955316640358569 0.999999999999956 GO:0004497 monooxygenase activity 6/1833 106/18639 0.0566037735849057 0.575579779513942 0.955888053356259 0.999999999999956 GO:0015370 solute:sodium symporter activity 4/1833 79/18639 0.0506329113924051 0.514864612898548 0.958511036940662 0.999999999999956 GO:0005452 solute:inorganic anion antiporter activity 1/1833 31/18639 0.032258064516129 0.328018584024075 0.959717983699036 0.999999999999956 GO:0047499 calcium-independent phospholipase A2 activity 1/1833 31/18639 0.032258064516129 0.328018584024075 0.959717983699036 0.999999999999956 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 37/1833 484/18639 0.0764462809917355 0.777349826189284 0.960814804528765 0.999999999999956 GO:0005178 integrin binding 10/1833 161/18639 0.062111801242236 0.631588577934554 0.961280322057068 0.999999999999956 GO:0008509 monoatomic anion transmembrane transporter activity 9/1833 149/18639 0.0604026845637584 0.614209294917563 0.963188279305382 0.999999999999956 GO:0019838 growth factor binding 8/1833 136/18639 0.0588235294117647 0.598151535573313 0.96347630769144 0.999999999999956 GO:0047498 calcium-dependent phospholipase A2 activity 1/1833 32/18639 0.03125 0.317768003273322 0.963686004758777 0.999999999999956 GO:0071813 lipoprotein particle binding 1/1833 32/18639 0.03125 0.317768003273322 0.963686004758777 0.999999999999956 GO:0071814 protein-lipid complex binding 1/1833 32/18639 0.03125 0.317768003273322 0.963686004758777 0.999999999999956 GO:0048020 CCR chemokine receptor binding 2/1833 50/18639 0.04 0.406743044189853 0.963706432847203 0.999999999999956 GO:0001618 virus receptor activity 4/1833 81/18639 0.0493827160493827 0.502151906407226 0.963978416874111 0.999999999999956 GO:0046943 carboxylic acid transmembrane transporter activity 12/1833 188/18639 0.0638297872340425 0.649058049239127 0.964073662449908 0.999999999999956 GO:0005342 organic acid transmembrane transporter activity 12/1833 189/18639 0.0634920634920635 0.645623879666433 0.965796010178747 0.999999999999956 GO:0140272 exogenous protein binding 4/1833 82/18639 0.0487804878048781 0.496028102670552 0.966453647812705 0.999999999999956 GO:0005272 sodium channel activity 2/1833 51/18639 0.0392156862745098 0.398767690382208 0.966730380302255 0.999999999999956 GO:0016597 amino acid binding 2/1833 51/18639 0.0392156862745098 0.398767690382208 0.966730380302255 0.999999999999956 GO:0019956 chemokine binding 1/1833 33/18639 0.0303030303030303 0.308138669840798 0.967263344108332 0.999999999999956 GO:0001216 DNA-binding transcription activator activity 37/1833 491/18639 0.0753564154786151 0.766267445775181 0.968642476647378 0.999999999999956 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1833 34/18639 0.0294117647058824 0.299075767786656 0.970488448389178 0.999999999999956 GO:0005246 calcium channel regulator activity 2/1833 53/18639 0.0377358490566038 0.383719853009295 0.972066808716314 0.999999999999956 GO:0038064 collagen receptor activity 2/1833 53/18639 0.0377358490566038 0.383719853009295 0.972066808716314 0.999999999999956 GO:0008514 organic anion transmembrane transporter activity 18/1833 269/18639 0.0669144981412639 0.680425166860348 0.972919192177765 0.999999999999956 GO:0004623 phospholipase A2 activity 1/1833 35/18639 0.0285714285714286 0.290530745849895 0.973395982605928 0.999999999999956 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/1833 54/18639 0.037037037037037 0.376613929805419 0.974415161088464 0.999999999999956 GO:0004190 aspartic-type endopeptidase activity 1/1833 36/18639 0.0277777777777778 0.282460447354064 0.976017201907333 0.999999999999956 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1833 36/18639 0.0277777777777778 0.282460447354064 0.976017201907333 0.999999999999956 GO:0033218 amide binding 16/1833 247/18639 0.0647773279352227 0.658693188971421 0.97615578397739 0.999999999999956 GO:0005518 collagen binding 3/1833 72/18639 0.0416666666666667 0.423690671031097 0.97743463890644 0.999999999999956 GO:0042379 chemokine receptor binding 3/1833 72/18639 0.0416666666666667 0.423690671031097 0.97743463890644 0.999999999999956 GO:0070001 aspartic-type peptidase activity 1/1833 37/18639 0.027027027027027 0.27482638120936 0.978380286834703 0.999999999999956 GO:0030170 pyridoxal phosphate binding 2/1833 56/18639 0.0357142857142857 0.363163432312368 0.978552525952206 0.999999999999956 GO:0070279 vitamin B6 binding 2/1833 57/18639 0.0350877192982456 0.356792144026187 0.980370281990275 0.999999999999956 GO:0005501 retinoid binding 1/1833 38/18639 0.0263157894736842 0.26759410801964 0.9805106456258 0.999999999999956 GO:0019840 isoprenoid binding 1/1833 38/18639 0.0263157894736842 0.26759410801964 0.9805106456258 0.999999999999956 GO:0042887 amide transmembrane transporter activity 1/1833 38/18639 0.0263157894736842 0.26759410801964 0.9805106456258 0.999999999999956 GO:0004879 nuclear receptor activity 2/1833 59/18639 0.0338983050847458 0.344697495076146 0.983568107673248 0.999999999999956 GO:0044325 transmembrane transporter binding 7/1833 136/18639 0.0514705882352941 0.523382593626649 0.983860488783858 0.999999999999956 GO:0098531 ligand-modulated transcription factor activity 2/1833 60/18639 0.0333333333333333 0.338952536824877 0.984971040135454 0.999999999999956 GO:0008237 metallopeptidase activity 10/1833 184/18639 0.0543478260869565 0.552640005692735 0.989073187130942 0.999999999999956 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/1833 44/18639 0.0227272727272727 0.231104002380598 0.989542472977425 0.999999999999956 GO:0030547 signaling receptor inhibitor activity 1/1833 44/18639 0.0227272727272727 0.231104002380598 0.989542472977425 0.999999999999956 GO:0042626 ATPase-coupled transmembrane transporter activity 4/1833 98/18639 0.0408163265306122 0.415043922642707 0.989713221944872 0.999999999999956 GO:0019955 cytokine binding 7/1833 144/18639 0.0486111111111111 0.494305782869613 0.990341507402648 0.999999999999956 GO:0008009 chemokine activity 1/1833 45/18639 0.0222222222222222 0.225968357883251 0.99057332250861 0.999999999999956 GO:0042605 peptide antigen binding 1/1833 45/18639 0.0222222222222222 0.225968357883251 0.99057332250861 0.999999999999956 GO:0005254 chloride channel activity 3/1833 83/18639 0.036144578313253 0.367538895352277 0.990732757461437 0.999999999999956 GO:0016757 glycosyltransferase activity 16/1833 267/18639 0.0599250936329588 0.609352875190791 0.990896166130641 0.999999999999956 GO:0015294 solute:monoatomic cation symporter activity 5/1833 116/18639 0.0431034482758621 0.4383006941701 0.991405435177087 0.999999999999956 GO:0016500 protein-hormone receptor activity 2/1833 67/18639 0.0298507462686567 0.303539585216308 0.991999045326277 0.999999999999956 GO:0038187 pattern recognition receptor activity 1/1833 48/18639 0.0208333333333333 0.211845335515548 0.993095499207185 0.999999999999956 GO:0005516 calmodulin binding 11/1833 207/18639 0.0531400966183575 0.540359116677341 0.993630095126985 0.999999999999956 GO:0005004 GPI-linked ephrin receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0005008 hepatocyte growth factor receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0005009 insulin receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0005011 macrophage colony-stimulating factor receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0005020 stem cell factor receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0008288 boss receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0036332 placental growth factor receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0038062 protein tyrosine kinase collagen receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0060175 brain-derived neurotrophic factor receptor activity 1/1833 49/18639 0.0204081632653061 0.207521961321353 0.993776256022485 0.999999999999956 GO:0008236 serine-type peptidase activity 10/1833 194/18639 0.0515463917525773 0.52415340746115 0.993943905552582 0.999999999999956 GO:0015108 chloride transmembrane transporter activity 5/1833 121/18639 0.0413223140495868 0.420189095237451 0.994030600441019 0.999999999999956 GO:0005006 epidermal growth factor receptor activity 1/1833 50/18639 0.02 0.203371522094926 0.994389925883205 0.999999999999956 GO:0005007 fibroblast growth factor receptor activity 1/1833 50/18639 0.02 0.203371522094926 0.994389925883205 0.999999999999956 GO:0005017 platelet-derived growth factor receptor activity 1/1833 50/18639 0.02 0.203371522094926 0.994389925883205 0.999999999999956 GO:0005019 platelet-derived growth factor beta-receptor activity 1/1833 50/18639 0.02 0.203371522094926 0.994389925883205 0.999999999999956 GO:0008528 G protein-coupled peptide receptor activity 5/1833 122/18639 0.040983606557377 0.416744922325669 0.994454227597875 0.999999999999956 GO:0005010 insulin-like growth factor receptor activity 1/1833 51/18639 0.0196078431372549 0.199383845191104 0.994943116794824 0.999999999999956 GO:0005021 vascular endothelial growth factor receptor activity 1/1833 51/18639 0.0196078431372549 0.199383845191104 0.994943116794824 0.999999999999956 GO:0005030 neurotrophin receptor activity 1/1833 51/18639 0.0196078431372549 0.199383845191104 0.994943116794824 0.999999999999956 GO:0017171 serine hydrolase activity 10/1833 198/18639 0.0505050505050505 0.513564449734663 0.995246303213299 0.999999999999956 GO:0005496 steroid binding 4/1833 108/18639 0.037037037037037 0.376613929805419 0.99525489498395 0.999999999999956 GO:0004620 phospholipase activity 4/1833 109/18639 0.036697247706422 0.37315875613748 0.995613739876786 0.999999999999956 GO:0005003 ephrin receptor activity 1/1833 53/18639 0.0188679245283019 0.191859926504648 0.995891304998403 0.999999999999956 GO:0005005 transmembrane-ephrin receptor activity 1/1833 53/18639 0.0188679245283019 0.191859926504648 0.995891304998403 0.999999999999956 GO:0008146 sulfotransferase activity 1/1833 53/18639 0.0188679245283019 0.191859926504648 0.995891304998403 0.999999999999956 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/1833 53/18639 0.0188679245283019 0.191859926504648 0.995891304998403 0.999999999999956 GO:0008201 heparin binding 8/1833 172/18639 0.0465116279069767 0.472957028127736 0.995995367629562 0.999999999999956 GO:0005096 GTPase activator activity 15/1833 271/18639 0.0553505535055351 0.562836315760866 0.996297209153457 0.999999999999956 GO:0001653 peptide receptor activity 5/1833 128/18639 0.0390625 0.397210004091653 0.996451053007458 0.999999999999956 GO:0004252 serine-type endopeptidase activity 8/1833 176/18639 0.0454545454545455 0.462208004761196 0.996926104725163 0.999999999999956 GO:0016298 lipase activity 5/1833 130/18639 0.0384615384615385 0.391099080951781 0.996946985024775 0.999999999999956 GO:0015293 symporter activity 6/1833 146/18639 0.0410958904109589 0.41788668923615 0.996989978253854 0.999999999999956 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/1833 56/18639 0.0178571428571429 0.181581716156184 0.996991041484647 0.999999999999956 GO:0170055 lipid transmembrane transporter activity 1/1833 56/18639 0.0178571428571429 0.181581716156184 0.996991041484647 0.999999999999956 GO:0022804 active transmembrane transporter activity 29/1833 457/18639 0.0634573304157549 0.645270693736637 0.997103954522055 0.999999999999956 GO:0015103 inorganic anion transmembrane transporter activity 7/1833 165/18639 0.0424242424242424 0.431394137777116 0.997665500195799 0.999999999999956 GO:0019842 vitamin binding 6/1833 150/18639 0.04 0.406743044189853 0.997747271327151 0.999999999999956 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/1833 60/18639 0.0166666666666667 0.169476268412439 0.998013919757814 0.999999999999956 GO:0030165 PDZ domain binding 2/1833 83/18639 0.0240963855421687 0.245025930234851 0.998163527040389 0.999999999999956 GO:0015026 coreceptor activity 1/1833 61/18639 0.0163934426229508 0.166697968930268 0.998209865991945 0.999999999999956 GO:0015291 secondary active transmembrane transporter activity 15/1833 287/18639 0.0522648083623693 0.531458681432734 0.99848346149238 0.999999999999956 GO:0022824 transmitter-gated monoatomic ion channel activity 1/1833 63/18639 0.0158730158730159 0.161405969916608 0.998545695423748 0.999999999999956 GO:0022835 transmitter-gated channel activity 1/1833 63/18639 0.0158730158730159 0.161405969916608 0.998545695423748 0.999999999999956 GO:0005267 potassium channel activity 4/1833 124/18639 0.032258064516129 0.328018584024075 0.998683615260682 0.999999999999956 GO:0008081 phosphoric diester hydrolase activity 2/1833 87/18639 0.0229885057471264 0.233760370224053 0.998735724991192 0.999999999999956 GO:0038024 cargo receptor activity 1/1833 65/18639 0.0153846153846154 0.156439632380713 0.998818551049848 0.999999999999956 GO:0005319 lipid transporter activity 7/1833 178/18639 0.0393258426966292 0.399887824343956 0.999073424073705 0.999999999999956 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1833 91/18639 0.021978021978022 0.223485189115304 0.999131228381221 0.999999999999956 GO:0015081 sodium ion transmembrane transporter activity 6/1833 164/18639 0.0365853658536585 0.372021077002914 0.999202379171394 0.999999999999956 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1833 69/18639 0.0144927536231884 0.147370668184729 0.999220343293965 0.999999999999956 GO:0005262 calcium channel activity 4/1833 131/18639 0.0305343511450382 0.310490873427368 0.999259604002428 0.999999999999956 GO:0016758 hexosyltransferase activity 8/1833 197/18639 0.0406091370558376 0.412937100700358 0.999271012659827 0.999999999999956 GO:0005201 extracellular matrix structural constituent 6/1833 168/18639 0.0357142857142857 0.363163432312368 0.999410850132672 0.999999999999956 GO:0004896 cytokine receptor activity 2/1833 96/18639 0.0208333333333333 0.211845335515548 0.999457737358997 0.999999999999956 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1833 73/18639 0.0136986301369863 0.139295563078717 0.999485540846782 0.999999999999956 GO:0005249 voltage-gated potassium channel activity 2/1833 98/18639 0.0204081632653061 0.207521961321353 0.999551220471713 0.999999999999956 GO:0005244 voltage-gated monoatomic ion channel activity 6/1833 173/18639 0.0346820809248555 0.352667379355364 0.999598036340994 0.999999999999956 GO:0022832 voltage-gated channel activity 6/1833 175/18639 0.0342857142857143 0.348636895019874 0.999655412691985 0.999999999999956 GO:0019199 transmembrane receptor protein kinase activity 1/1833 78/18639 0.0128205128205128 0.13036636031726 0.999694083716547 0.999999999999956 GO:0005539 glycosaminoglycan binding 10/1833 242/18639 0.0413223140495868 0.420189095237451 0.999727590995779 0.999999999999956 GO:0008083 growth factor activity 5/1833 162/18639 0.0308641975308642 0.313844941504516 0.999751304291144 0.999999999999956 GO:0008194 UDP-glycosyltransferase activity 4/1833 145/18639 0.0275862068965517 0.280512444268864 0.999770943084708 0.999999999999956 GO:0015085 calcium ion transmembrane transporter activity 4/1833 147/18639 0.0272108843537415 0.276695948428471 0.999806714064616 0.999999999999956 GO:0004222 metalloendopeptidase activity 2/1833 110/18639 0.0181818181818182 0.184883201904478 0.999856859295695 0.999999999999956 GO:0099094 ligand-gated monoatomic cation channel activity 3/1833 136/18639 0.0220588235294118 0.224306825839992 0.999907620755797 0.999999999999956 GO:0015079 potassium ion transmembrane transporter activity 4/1833 160/18639 0.025 0.254214402618658 0.999936657440267 0.999999999999956 GO:0042562 hormone binding 1/1833 94/18639 0.0106382978723404 0.108176341539854 0.999942086857613 0.999999999999956 GO:0030246 carbohydrate binding 11/1833 280/18639 0.0392857142857143 0.399479775543605 0.999942794924365 0.999999999999956 GO:0030594 neurotransmitter receptor activity 1/1833 97/18639 0.0103092783505155 0.10483068149223 0.999957618708008 0.999999999999956 GO:0004175 endopeptidase activity 19/1833 405/18639 0.0469135802469136 0.477044311086864 0.999960634170413 0.999999999999956 GO:0005179 hormone activity 2/1833 132/18639 0.0151515151515152 0.154069334920399 0.999982858691007 0.999999999999956 GO:0005125 cytokine activity 7/1833 234/18639 0.0299145299145299 0.304188174073608 0.999987120669991 0.999999999999956 GO:0022843 voltage-gated monoatomic cation channel activity 2/1833 143/18639 0.013986013986014 0.14221784761883 0.999994131652393 0.999999999999956 GO:0003823 antigen binding 3/1833 174/18639 0.0172413793103448 0.17532027766804 0.999997207811078 0.999999999999956 GO:0140375 immune receptor activity 2/1833 156/18639 0.0128205128205128 0.13036636031726 0.999998359280608 0.999999999999956 GO:0015276 ligand-gated monoatomic ion channel activity 3/1833 186/18639 0.0161290322580645 0.164009292012037 0.99999909497551 0.999999999999956 GO:0022834 ligand-gated channel activity 3/1833 188/18639 0.0159574468085106 0.162264512309782 0.999999250542923 0.999999999999956 GO:0005261 monoatomic cation channel activity 11/1833 341/18639 0.032258064516129 0.328018584024075 0.999999345281341 0.999999999999956 GO:0005216 monoatomic ion channel activity 17/1833 448/18639 0.0379464285714286 0.385861146831891 0.999999676296942 0.999999999999956 GO:0022836 gated channel activity 9/1833 318/18639 0.0283018867924528 0.287789889756971 0.999999737231955 0.999999999999956 GO:0046873 metal ion transmembrane transporter activity 14/1833 450/18639 0.0311111111111111 0.316355701036552 0.999999992378719 0.999999999999956 GO:0045182 translation regulator activity 8/1833 356/18639 0.0224719101123595 0.228507328196546 0.999999997651861 0.999999999999956 GO:0030371 translation repressor activity 2/1833 329/18639 0.0060790273556231 0.0618150523084883 0.999999999999956 0.999999999999956