category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	97/712	222/9376	5.7538212369673	RPL17/RPL36A/RPS10/RPL5/RPL29/RPS9/RPS26/RPL27/RPL31/RPL7/RPL3/RPL9/RPL10A/RPSA/RPS3/RPL35A/RPS20/RPL6/RPL19/RPS5/RPL22/RPL15/RPL14/RPL24/RPS4X/RPL8/RPS6/RPL35/RPL23A/UBA52/RPL11/RPL7A/RPS25/RPL26/RPL18A/RPS3A/RPL12/RPL27A/RPS13/RPL41/RPLP0/RPL13A/RPS11/RPL21/RPS15A/RPS16/RPS27A/RPS19/RPS8/RPL10/RPS24/RPL4/RPL32/RPS23/RPS2/RPL13/RPLP1/RPL28/RPS12/RPS14/RPS18/RPL30/RPS15/RPLP2/RPS7/RPL23/RPL18/RPL37/RPL34/RPS4Y1/RPL38/RPS17/MRPL51/MRPS15/RPL36AL/MRPS6/MRPL27/MRPL11/MRPL42/MRPS11/MRPL35/MRPS7/RPL22L1/MRPL52/MRPL10/MRPL41/MRPL44/MRPS22/MRPL3/MRPL48/RPL26L1/MRPL16/MRPL28/MRPS28/MRPL49/MRPL15/MRPL23	20.5485079545424
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	83/712	238/9376	4.59238976489472	RPL17/RPL36A/RPS10/RPL5/RPL29/RPS9/RPS26/RPL27/RPL31/RPL7/RPL3/RPL9/RPL10A/RPSA/RPS3/RPL35A/RPS20/RPL6/RPL19/RPS5/RPL22/RPL15/RPL14/RPL24/RPS4X/RPL8/RPS6/RPL35/RPL23A/UBA52/RPL11/RPL7A/RPS25/RPL26/RPL18A/RPS3A/RPL12/RPL27A/RPS13/RPL41/RPLP0/RPL13A/RPS11/RPL21/RPS15A/RPS16/RPS27A/RPS19/RPS8/RPL10/RPS24/RPL4/RPL32/RPS23/RPS2/RPL13/RPLP1/RPL28/RPS12/RPS14/RPS18/RPL30/RPS15/RPLP2/RPS7/RPL23/RPL18/RPL37/RPL34/RPS4Y1/RPL38/RPS17/MX1/ISG15/RPL36AL/F13A1/RPL22L1/FCGR2A/OAS2/CYBB/RPL26L1/MX2/NFKBIB	16.0921015759614
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	81/712	268/9376	3.98004360221365	CALM1/UQCRH/TXN/UBA52/RPS27A/SLC25A6/VDAC1/PARK7/TUBA1B/PSMB3/TUBA1C/COX5A/COX7C/PSMD8/COX7B/UBE2L3/NDUFA11/TUBB4B/PSMB1/PSMA2/CALM2/VDAC2/COX6B1/UQCR10/SLC25A5/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/NDUFB3/PSMB5/CYCS/SOD1/PSMC1/UQCRFS1/NDUFA13/UBC/TUBA4A/NDUFA12/NDUFB4/PSMC3/PSMA3/SDHC/UQCRB/TUBB/NDUFAB1/SNCA/SDHB/COX7A2L/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/UBB/NDUFA9/SDHA/COX6C/UBE2J2/CALM3/NDUFS6/UBE2L6/PSMB4/NDUFS3/PSMC4/SLC39A4/UQCRC2/NDUFB8/COX7A1	14.1887755168818
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	77/712	275/9376	3.68719101123596	CAV1/UQCRH/SLC25A6/VDAC1/TUBA1B/PSMB3/TUBA1C/CSNK2B/COX5A/COX7C/PSMD8/COX7B/RAC1/NDUFA11/TUBB4B/PSMB1/PSMA2/VDAC2/COX6B1/UQCR10/SLC25A5/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/CCL5/NDUFB3/PSMB5/CYCS/CYBA/SOD1/PSMC1/UQCRFS1/NDUFA13/TUBA4A/NDUFA12/NDUFB4/PSMC3/PSMA3/NCF1/SDHC/UQCRB/TUBB/NDUFAB1/SDHB/COX7A2L/NCF2/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/NDUFA9/SDHA/COX6C/CYBB/NDUFS6/PSMB4/NCF4/NDUFS3/PSMC4/RAC2/UQCRC2/NDUFB8/COX7A1	12.9654245150107
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	80/712	308/9376	3.42039982489421	GPX1/UQCRH/GPX3/SLC25A6/VDAC1/TUBA1B/PSMB3/TUBA1C/COX5A/COX7C/PSMD8/COX7B/NDUFA11/TUBB4B/PSMB1/CLTA/CLTB/PSMA2/VDAC2/COX6B1/UQCR10/SLC25A5/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/NDUFB3/PSMB5/CYCS/SOD1/PSMC1/UQCRFS1/NDUFA13/TUBA4A/AP2S1/NDUFA12/NDUFB4/PSMC3/PSMA3/SDHC/UQCRB/TUBB/NDUFAB1/SDHB/COX7A2L/POLR2E/POLR2H/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/TBPL1/NDUFA9/DCTN2/SDHA/COX6C/POLR2D/NDUFS6/DCTN6/PSMB4/NDUFS3/PSMC4/UQCRC2/NDUFB8/DNAL4/POLR2L/COX7A1	12.3814961963418
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	82/712	368/9376	2.9342940889106	GPX1/ACTG1/PFN1/HNRNPA1/UQCRH/GPX3/VDAC1/TUBA1B/PSMB3/TUBA1C/COX5A/COX7C/PSMD8/COX7B/SRSF3/RAC1/NDUFA11/TUBB4B/PSMB1/CHCHD10/PSMA2/COX6B1/UQCR10/ACTB/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/NDUFB3/PSMB5/CYCS/SOD1/PSMC1/UQCRFS1/HNRNPA3/NDUFA13/TUBA4A/NDUFA12/NDUFB4/PSMC3/TNFRSF1B/PSMA3/SDHC/UQCRB/TUBB/NDUFAB1/SDHB/COX7A2L/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/ALYREF/NDUFA9/DCTN2/SDHA/COX6C/NDUFS6/DCTN6/NUP54/PSMB4/NUP93/NDUFS3/PSMC4/RAB1A/UQCRC2/NDUFB8/DNAL4/COX7A1	10.8517214747544
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	46/712	138/9376	4.38951310861423	UQCRH/COX5A/COX7C/COX7B/NDUFA11/COX6B1/PPA1/UQCR10/UQCRQ/NDUFS5/COX8A/COX4I1/NDUFA6/COX8C/NDUFA4/COX7B2/NDUFB3/CYCS/ATP6V1F/UQCRFS1/NDUFA13/NDUFA12/NDUFB4/SDHC/UQCRB/NDUFAB1/SDHB/COX7A2L/NDUFV2/ATP6V0E1/NDUFB6/ATP6V0D1/COX5B/COX17/UQCR11/NDUFA9/SDHA/COX6C/NDUFS6/PPA2/COX11/NDUFS3/ATP6V1D/UQCRC2/NDUFB8/COX7A1	11.4988469964894
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	90/712	480/9376	2.46910112359551	GPX1/CALM1/UQCRH/UBA52/RPS27A/GPX3/SLC25A6/VDAC1/PARK7/TUBA1B/PSMB3/TUBA1C/CSNK2B/COX5A/COX7C/PSMD8/COX7B/UBE2L3/RAC1/NDUFA11/TUBB4B/PSMB1/PSMA2/CALM2/VDAC2/COX6B1/UQCR10/SLC25A5/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/NDUFB3/PSMB5/CYCS/SOD1/PSMC1/UQCRFS1/NDUFA13/UBC/TUBA4A/NDUFA12/NDUFB4/PSMC3/TNFRSF1B/PSMA3/SDHC/UQCRB/TUBB/NDUFAB1/SNCA/SDHB/COX7A2L/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/UBB/NDUFA9/DCTN2/SDHA/COX6C/UBE2J2/CYBB/CALM3/NDUFS6/DCTN6/UBE2L6/PSMB4/NDUFS3/PSMC4/RAB1A/UQCRC2/NDUFB8/DNAL4/COX7A1/PPID	9.47199228564555
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	53/712	205/9376	3.40454919155933	GAPDH/UQCRH/SLC25A6/VDAC1/COX5A/COX7C/COX7B/RAC1/NDUFA11/VDAC2/COX6B1/UQCR10/SLC25A5/TGFB1/UQCRQ/NDUFS5/COX8A/COX4I1/NDUFA6/COX8C/NDUFA4/COX7B2/NDUFB3/PPP1CA/CYBA/UQCRFS1/NDUFA13/NDUFA12/NDUFB4/NCF1/SDHC/UQCRB/NDUFAB1/SDHB/COX7A2L/NCF2/NDUFV2/NDUFB6/COX5B/UQCR11/NDUFA9/SDHA/COX6C/CYBB/NDUFS6/NCF4/NDUFS3/RAC2/UQCRC2/PDHA1/NDUFB8/COX7A1/AKT1	9.97857815490261
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/712	388/9376	2.61334414456157	GAPDH/CALM1/UQCRH/SLC25A6/VDAC1/TUBA1B/PSMB3/TUBA1C/CSNK2B/COX5A/COX7C/PSMD8/COX7B/NDUFA11/TUBB4B/PSMB1/PSMA2/CALM2/VDAC2/COX6B1/UQCR10/SLC25A5/PSMA7/PSMA1/UQCRQ/NDUFS5/COX8A/PSMB2/COX4I1/NDUFA6/PSMA5/PSMB6/TUBB6/PSMD4/PSMB7/COX8C/NDUFA4/COX7B2/NDUFB3/PSMB5/CYCS/PSMC1/UQCRFS1/NDUFA13/TUBA4A/NDUFA12/NDUFB4/PSMC3/PSMA3/SDHC/UQCRB/LPL/TUBB/NDUFAB1/SNCA/SDHB/COX7A2L/NDUFV2/PSMA4/NDUFB6/COX5B/UQCR11/NDUFA9/SDHA/COX6C/CYBB/CALM3/NDUFS6/PSMB4/NDUFS3/PSMC4/SLC39A4/UQCRC2/NDUFB8/COX7A1/PPID/AKT1	9.30417266467633
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	23/712	46/9376	6.58426966292135	POMP/PSMB3/PSMD8/PSME2/PSMB1/PSMA2/PSMA7/PSMA1/PSMB2/PSMA5/PSMB6/PSMD4/PSMB7/PSME1/PSMB5/PSMC1/PSMB8/PSMC3/PSMA3/PSMA4/PSMB9/PSMB4/PSMC4	10.8835578307243
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/712	157/9376	3.60667000644099	UQCRH/COX5A/COX7C/COX7B/RAC1/NDUFA11/LEP/COX6B1/UQCR10/TGFB1/UQCRQ/NDUFS5/COX8A/CDC42/COX4I1/NDUFA6/COX8C/NDUFA4/COX7B2/NDUFB3/CYCS/UQCRFS1/NDUFA13/NDUFA12/NDUFB4/SDHC/UQCRB/NDUFAB1/SDHB/COX7A2L/NDUFV2/NDUFB6/COX5B/UQCR11/NDUFA9/SDHA/COX6C/NDUFS6/NDUFS3/UQCRC2/NDUFB8/COX7A1/AKT1	9.44192152849934
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	50/712	227/9376	2.90055932287284	GSTO1/UQCRH/SLC25A6/VDAC1/COX5A/COX7C/COX7B/RAC1/NDUFA11/VDAC2/COX6B1/UQCR10/SLC25A5/UQCRQ/NDUFS5/COX8A/COX4I1/NDUFA6/COX8C/NDUFA4/COX7B2/NDUFB3/CYBA/SOD1/UQCRFS1/NDUFA13/NDUFA12/NDUFB4/NCF1/SDHC/UQCRB/NDUFAB1/SDHB/COX7A2L/NCF2/NDUFV2/NDUFB6/AKR1A1/COX5B/UQCR11/ACP1/NDUFA9/SDHA/COX6C/NDUFS6/NDUFS3/UQCRC2/NDUFB8/COX7A1/AKT1	8.30948212554295
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/712	235/9376	2.68974420272532	ACTG1/UQCRH/RPS6/COX5A/COX7C/COX7B/NDUFA11/COX6B1/UQCR10/ACTB/UQCRQ/NDUFS5/COX8A/COX4I1/NDUFA6/COX8C/COX20/NDUFA4/COX7B2/NDUFB3/UQCRFS1/NDUFA13/NDUFA12/NDUFB4/SDHC/UQCRB/COA3/NDUFAB1/SDHB/COX7A2L/NDUFV2/NDUFB6/COX5B/COX17/UQCR11/NDUFA9/COA6/SDHA/COX6C/NDUFS6/COA5/COX11/COA1/NDUFS3/UQCRC2/COA7/NDUFB8/COX7A1	7.52011453207522
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	22/712	87/9376	3.32997546170735	UQCRH/COX5A/COX7C/COX7B/COX6B1/UQCR10/TPM4/UQCRQ/COX8A/COX4I1/COX8C/COX7B2/UQCRFS1/TPM3/UQCRB/COX7A2L/COX5B/UQCR11/COX6C/TPM1/UQCRC2/COX7A1	6.25882639365763
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/712	155/9376	2.5487495469373	ACTG1/TUBA1B/TUBA1C/RAC1/TUBB4B/ACTB/SEC61B/TUBB6/SEC61G/ATP6V1F/CYBA/TUBA4A/HLA-F/NCF1/FCGR3A/TUBB/CTSS/HLA-B/FCGR2A/NCF2/ATP6V0E1/ATP6V0D1/CORO1A/HLA-A/CYBB/STX18/NCF4/HLA-C/ATP6V1D/HLA-DPA1	5.5734542894289
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	41/712	248/9376	2.17705690467561	DYNLL1/GAPDH/ACTG1/PFN1/TXN/RPS3/MYL12B/S100A10/ARPC3/SKP1/DYNLRB1/RHOA/MYL12A/TUBA1B/TUBA1C/DYNLT1/RAC1/ARPC2/ANXA2/TUBB4B/HSP90AB1/ACTB/CDC42/TUBB6/CYCS/TUBA4A/MYL9/PTPRC/FLNA/TUBB/BRK1/ARPC5/LY96/DCTN2/ARPC1A/RHOG/DCTN6/RAB9A/RIPK2/RALA/AKT1	5.38520074477828
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	19/712	85/9376	2.94355584930601	UPP1/NME1/TYMS/APRT/UCK2/TK1/RRM2/CDA/IMPDH2/DUT/AK2/GUK1/ADSL/GMPR2/NT5E/DCTD/ASMTL/CTPS1/HPRT1	5.15990458510912
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/712	157/9376	2.2646532598583	CALM1/SLC25A6/VDAC1/CALM2/SERPINE1/IGFBP3/VDAC2/SLC25A5/TGFB1/CDK1/CCNE1/PPP1CA/EIF4EBP1/HLA-F/HLA-B/CCNB1/HLA-A/CALM3/CHEK1/CCNA2/CDK4/HLA-C/ZFP36L2/HUS1/CCNB2/PPID/AKT1	4.58084713862427
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/712	116/9376	2.49748159628051	PKM/ALDOA/TPI1/ENO1/GAPDH/PGAM1/MDH2/GCSH/TALDO1/PFKP/PGK1/ECHS1/SDHC/SDHB/MDH1/IDH3B/SDHA/SHMT2/PDHA1/FH/GPI/ACAT1	4.65212535059377
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	25/712	144/9376	2.28620474406991	SLC25A6/VDAC1/PSMB3/PSMD8/PSMB1/PSMA2/VDAC2/SLC25A5/PSMA7/PSMA1/PSMB2/PSMA5/PSMB6/PSMD4/PSMB7/PSMB5/CYCS/PSMC1/PSMC3/PSMA3/PSMA4/TBPL1/PSMB4/PSMC4/AKT1	4.45871659364768
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	37/712	253/9376	1.9258338144513	ACTG1/PFN1/UBA52/MYL12B/RPS27A/ARPC3/SKP1/RHOA/MYL12A/VDAC1/RAC1/ARPC2/RBX1/ACTB/CDC42/CCL5/CYCS/UBE2N/UBC/MYL9/RRAGD/ARPC5/UBB/ARPC1A/CAPNS1/TIFA/SHARPIN/RIPK2/GLMN/UBE2V1/UBE2D2/UBE2D1/UBE2D3/NFKBIB/PPID/ATG5/AKT1	4.27947875729582
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/712	59/9376	3.12473814511522	UPP1/NME1/TYMS/UCK2/TK1/RRM2/CDA/DUT/UMPS/NT5E/NUDT2/DCTD/ASMTL/CTPS1	4.69309976089139
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/712	98/9376	2.41871130474662	CFL1/ARPC3/RAC1/ARPC2/MARCKS/LYN/CDC42/NCF1/PTPRC/FCGR3A/FCGR2A/ARPC5/ARPC1A/WAS/HCK/RAC2/CFL2/AKT1	4.04712199970127
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	22/712	142/9376	2.04019623358126	UBA52/RPS27A/SKP1/ANAPC11/UBE2L3/UBE2I/RBX1/UBE2C/UBE2N/UBC/CDC20/UBE2E3/ANAPC10/UBB/UBE2J2/UBE2L6/UBA2/CDC34/UBE2D2/UBE2D1/UBE2D3/ANAPC15	3.58039487833999
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/712	36/9376	3.29213483146067	SSBP1/POLE3/PCNA/RPA2/RNASEH2C/RFC3/RNASEH1/RPA3/POLE4	3.94988440731351
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/712	67/9376	2.55508971993963	LDHA/PKM/ALDOA/TPI1/ENO1/GAPDH/PGAM1/PFKP/PGK1/AKR1A1/BPGM/PDHA1/GPI	3.66191070448914
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/712	30/9376	3.51161048689139	MDH2/SDHC/SDHB/MDH1/IDH3B/SDHA/PDHA1/FH	3.94972119002359
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/712	224/9376	1.76364365971108	RAN/ANAPC11/SLC25A6/VDAC1/RANBP1/VDAC2/SLC25A5/TGFB1/PTTG1/CCNE1/HLA-F/CDC20/HLA-B/TSPO/ANAPC10/MSX1/MAD2L1/TBPL1/HLA-A/SPI1/FOSL1/CHEK1/CCNA2/CDK4/HLA-C/NFYB/CCNB2/HLA-DPA1/ANAPC15/AKT1	3.31606600901389
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/712	63/9376	2.50829320492242	RBX1/POLE3/POLR2E/PCNA/RPA2/POLR2H/CETN2/RFC3/RPA3/POLR2D/POLE4/POLR2L	3.44332218698845
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/712	116/9376	2.04339403332042	ACTG1/MYL12B/RHOA/MYL12A/RAC1/ACTB/CDC42/CYBA/MYL9/NCF1/CD99/NCF2/CXCR4/ESAM/RAP1A/CYBB/NCF4/RAC2	3.24144206187555
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	22/712	154/9376	1.88121990369181	UGP2/NME1/ALAS2/AK2/RDH13/ALPP/MMAB/VKORC1/KYNU/AKR1A1/COQ5/GMPPA/MTHFD2/ADSL/SHMT2/UMPS/NAPRT/HMBS/LIPT2/CTPS1/GMPPB/PMM1	3.16081088649479
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/712	138/9376	1.90848396026706	CALM1/SKP1/ANAPC11/YWHAE/CALM2/RBX1/PTTG1/CDK1/CCNE1/PPP1CA/YWHAQ/CDC20/ANAPC10/MAD2L1/CCNB1/CALM3/YWHAH/CCNB2/ANAPC15/PPP2CA	3.08201140492023
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/712	35/9376	3.0099518459069	ALDOA/TPI1/AKR1B1/PFKP/TIGAR/GMPPA/GMPPB/PMM1	3.41498973143202
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/712	158/9376	1.83359408334519	SKP1/ANAPC11/YWHAE/RBX1/TGFB1/PTTG1/CDK1/CCNE1/YWHAQ/CDC20/PCNA/ANAPC10/MAD2L1/CCNB1/YWHAH/CHEK1/CCNA2/CDK4/CCNB2/AURKB/ANAPC15/PPP2CA	3.02922287865821
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/712	170/9376	1.78162590879048	ACTG1/MYL6/MYL12B/ARPC3/RHOA/MYL12A/TUBA1B/TUBA1C/RAC1/ARPC2/YBX3/ACTB/CDC42/TUBA4A/MYL9/PCNA/RAP1A/ARPC5/ARPC1A/WAS/CDK4/CRB3/PPP2CA	2.94818230521836
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/712	200/9376	1.71191011235955	GAPDH/ACTG1/RPS3/ARPC3/RHOA/TUBA1B/TUBA1C/RAC1/ARPC2/TUBB4B/ACTB/CDC42/TUBB6/CYCS/NCL/TUBA4A/TUBB/FCGR2A/WIPF1/BRK1/ARPC5/ARPC1A/RAB1A/ABCF2/NFKBIB/MYO1F	2.9172917949357
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/712	142/9376	1.85472384871024	CAV1/GSTO1/ACTG1/CALM1/TXN/GSTP1/RHOA/RAC1/SUMO2/CALM2/HSP90AB1/ACTB/CYBA/NCF1/SUMO1/NCF2/SUMO3/CALM3/RAC2/AKT1	2.94199189683771
Genetic Information Processing	Transcription	hsa03040	Spliceosome	30/712	243/9376	1.62574559578305	HNRNPA1/SNRPD2/SNRPE/SNRPG/LSM3/SNU13/SNRPD1/HNRNPC/SRSF3/SNRPF/SF3B6/SNRPC/SNRPB/RBM8A/SRSF9/SNRPD3/SF3B5/MAGOH/HNRNPA3/LSM4/LSM5/SMNDC1/RBM17/MAGOHB/ALYREF/TXNL4A/SNRPA1/PRPF38A/SF3B4/PPIE	2.83309164128321
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/712	78/9376	2.19475655430712	CAV1/ACTG1/ARPC3/RHOA/RAC1/ARPC2/CLTA/CLTB/ACTB/CDC42/ARPC5/ARPC1A/RHOG	3.03737465930523
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/712	47/9376	2.52163519005498	LDHA/PKM/MDH2/MDH1/AKR1A1/PDHA1/ACYP1/FH/ACAT1	2.9978392336476
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	30/712	250/9376	1.58022471910112	CAV1/ARPC3/RHOA/ARPC2/CLTA/CLTB/CDC42/RAB11A/CAPZB/VPS29/CHMP2A/ARF4/AP2S1/HLA-F/SMAP1/HLA-B/CXCR4/WIPF1/RAB4A/ARPC5/VPS37A/HLA-A/ARPC1A/CHMP4A/RAB11B/FOLR2/SNX3/HLA-C/SH3GL1/VTA1	2.66558424162779
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/712	93/9376	1.98236075872901	ACTG1/MYL12B/RHOA/MYL12A/CSNK2B/RAC1/ACTB/CDC42/MYL9/RAP1A/ACP1/WAS/RAC2/PDCD10	2.72919594993803
Cellular Processes	Cell motility	hsa04814	Motor proteins	24/712	194/9376	1.62909764855786	DYNLL1/ACTG1/MYL6/MYL12B/DYNLRB1/MYL12A/TUBA1B/TUBA1C/DYNLT1/TUBB4B/ACTB/TPM4/TUBB6/CAPZB/TUBA4A/MYL9/TPM3/TUBB/DCTN2/DCTN6/TNNI2/TPM1/DNAL4/MYO1F	2.5381465595671
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/712	70/9376	2.069341894061	CAV1/ACTG1/RAC1/ACTB/CYCS/HLA-F/HLA-B/HLA-A/HLA-C/RAC2/HLA-DPA1	2.57424863313711
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/712	37/9376	2.49134527786213	UGP2/NANS/GMPPA/GNPNAT1/GMPPB/PMM1/GPI	2.60552527828728
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/712	82/9376	1.92710331597698	GSTO1/GSTP1/UPP1/NME1/UCK2/TK1/RRM2/CDA/IMPDH2/DUT/UMPS/HPRT1	2.41713072992291
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/712	205/9376	1.54168265278158	PKM/RHOA/RANBP1/YWHAE/RAC1/LYN/CDC42/CDK1/CCNE1/PSMC1/YWHAQ/HLA-F/CDC20/HLA-B/ATP6V0D1/TBPL1/HLA-A/YWHAH/CHEK1/CCNA2/HDAC3/CDK4/HLA-C/GTF2A2	2.24791520377704
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/712	75/9376	1.93138576779026	PKM/ALDOA/TPI1/ENO1/GAPDH/PGAM1/TALDO1/PFKP/PGK1/IDH3B/SHMT2	2.32146328798447
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/712	75/9376	1.93138576779026	SERPINE1/IGFBP3/CDK1/RRM2/CCNE1/CYCS/TP53I3/CCNB1/CHEK1/CDK4/CCNB2	2.32146328798447
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/712	23/9376	2.86272594040059	SSBP1/PCNA/RPA2/RFC3/RPA3	2.56391620131138
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/712	31/9376	2.5487495469373	MDH2/GCSH/MDH1/SHMT2/HYI/ACAT1	2.47593249448129
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/712	78/9376	1.85710169979833	EEF1A1/TGFB1/CYBA/NCF1/FCGR3A/FCGR2A/NCF2/CYBB/NCF4/HLA-DPA1/NFKBIB	2.1789702463065
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/712	108/9376	1.7070328755722	RAN/EEF1A1/SAP18/SUMO2/UBE2I/RBM8A/MAGOH/SUMO1/MAGOHB/ALYREF/SUMO3/NUP54/NUP93/KPNA2	2.11848252757773
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/712	214/9376	1.47684553187021	CALM1/CFL1/SKP1/GNG11/RAC1/CALM2/RBX1/CDK1/CYCS/HLA-F/TNFRSF1B/HLA-B/CXCR4/CCNB1/APOBEC3A/HLA-A/CALM3/CHEK1/HLA-C/RAC2/CFL2/CCNB2/AKT1/AP1S2	2.02281364130891
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/712	51/9376	2.06565322758317	ACTG1/ACTB/SEC61B/SEC61G/ATP6V1F/ATP6V0E1/ATP6V0D1/ATP6V1D	2.18747443266674
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/712	110/9376	1.67599591419816	LDHA/ALDOA/ENO1/GAPDH/RPS6/SERPINE1/RBX1/PFKP/EIF4EBP1/PGK1/EGLN3/CYBB/PDHA1/AKT1	2.04437555267494
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/712	44/9376	2.0949948927477	HMGB1/POLE3/MPG/PCNA/RFC3/UNG/POLE4	2.08697612105519
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/712	73/9376	1.80390949669078	PPIA/RAN/MX1/CPSF6/CXCR4/APOBEC3A/CHMP4A/PIN1/MLLT1/MX2	1.97662139497377
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/712	54/9376	1.95089471493966	LDHA/MDH2/SMS/MDH1/APIP/ADI1/CISD1/MPST	2.00882071150023
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/712	46/9376	2.00390815828041	FTH1/BLVRA/ALAS2/HMOX2/MMAB/HMBS/FTL	1.95658396834385
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/712	28/9376	2.35152487961477	ATP6V1F/ATP6V0E1/ATP6V0D1/SLC4A1/ATP6V1D	2.05310008918954
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/712	138/9376	1.52678716821365	ACTG1/ARPC3/RHOA/RAC1/ARPC2/ACTB/CDC42/FCGR2A/WIPF1/ARPC5/LCP2/ARPC1A/RHOG/WAS/RAC2/AKT1	1.78711362160189
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/712	20/9376	2.63370786516854	UGP2/NANS/GMPPA/GMPPB	2.09657645539971
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/712	38/9376	2.07924305144885	UGP2/GMPPA/GNPNAT1/GMPPB/PMM1/GPI	1.91095534187075
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/712	59/9376	1.78556465435155	GPX1/GSTO1/GSTP1/PRDX6/GPX3/GPX4/RRM2/SMS	1.73514712858985
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/712	31/9376	2.12395795578108	SEC61B/SRP14/SRP9/SEC61G/SEC11A	1.7968328259739
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/712	41/9376	1.92710331597698	PGAM1/GCSH/ALAS2/SHMT2/BPGM/GAMT	1.7054120012278
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/712	71/9376	1.66925146383922	LDHA/PKM/PGAM1/SLC16A3/PFKP/TIGAR/SCO2/PDHA1/AKT1	1.62265700373041
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/712	82/9376	1.60591942998082	PSME2/HSP90AB1/PSME1/HLA-F/CTSS/HLA-B/HLA-A/HLA-C/NFYB/HLA-DPA1	1.57974461834453
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/712	42/9376	1.88121990369181	FTH1/GPX4/VDAC2/CYBB/FTL/ATG5	1.64074639203092
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	21/712	205/9376	1.34897232118389	PSMD8/RAC1/ISG15/LYN/PSMD4/CCNE1/CYCS/PSMC1/HLA-F/PSMC3/HLA-B/HLA-A/OAS2/CCNA2/CDK4/HLA-C/PSMC4/VIM/HLA-DPA1/NFKBIB/AKT1	1.44819145021232
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/712	149/9376	1.41407133700324	GNG11/NDUFA11/NDUFS5/NDUFA6/NDUFA4/NDUFB3/NDUFA13/NDUFA12/NDUFB4/NDUFAB1/NDUFV2/NDUFB6/NDUFA9/NDUFS6/NDUFS3/NDUFB8	1.46050973386176
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/712	15/9376	2.63370786516854	AK2/ALPP/ACP1	1.8152034988629
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/712	95/9376	1.52477823772915	TGFB1/CCL5/ATP6V1F/CCL3L3/LTB/ATP6V0E1/ATP6V0D1/TNFSF13B/CCL3/ATP6V1D/HLA-DPA1	1.47369172976117
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/712	107/9376	1.47684553187021	LDHA/PKM/CALM1/CALM2/PGAM1/PYGL/PRMT1/PFKP/PPP4C/CALM3/PDHA1/AKT1	1.42206542857949
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/712	34/9376	1.93654990085922	POLR2E/POLR2H/POLR3D/POLR2D/POLR2L	1.56825565585606
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/712	232/9376	1.30550174351027	TMSB4X/ACTG1/PFN1/CFL1/MYL12B/ARPC3/RHOA/MYL12A/RAC1/ARPC2/ACTB/CDC42/RGCC/PPP1CA/MYL9/CXCR4/BRK1/ARPC5/ARPC1A/SPATA13/RAC2/CFL2/AKT1	1.35069095031413
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/712	44/9376	1.79570990806946	DYNLL1/RAB11A/ARHGDIB/DCTN2/RAB11B/DCTN6	1.51656193871454
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/712	187/9376	1.33797993150273	TXN/RHOA/VDAC1/TXNIP/YWHAE/VDAC2/HSP90AB1/CCL5/CYBA/TRIP6/OAS2/NAMPT/CYBB/GBP2/SHARPIN/RIPK2/GPSM3/NFKBIB/ATG5	1.33827080681275
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/712	120/9376	1.42659176029963	CALM1/RHOA/YWHAE/RAC1/CALM2/CDC42/SH2B2/ARHGDIB/RAP1A/CALM3/RIPK2/NFKBIB/AKT1	1.34821087510345
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/712	78/9376	1.51944684528954	ENO1/LSM3/PFKP/LSM4/LSM5/EXOSC9/EXOSC1/EXOSC4/EXOSC7	1.32056583330777
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/712	216/9376	1.28027465667915	CALM1/RHOA/RAC1/CALM2/CYP2J2/HSP90AB1/LYN/CDC42/CCL5/CYCS/CYBA/CCL3L3/NCF1/NCF2/RAP1A/LY96/CYBB/CALM3/NCF4/CCL3/AKT1	1.19461889942722
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/712	193/9376	1.29638470047156	RHOA/PPBP/GNG11/RAC1/PF4/LYN/CDC42/CCL5/CCL3L3/NCF1/PREX1/CXCR4/RAP1A/WAS/HCK/CCL3/RAC2/NFKBIB/AKT1	1.19263776426379
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/712	18/9376	2.19475655430712	PRDX1/MMAB/THAP11	1.4544224415119
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/712	103/9376	1.40634886004145	SAP18/RBM8A/PPP1CA/MAGOH/CPSF6/MAGOHB/ALYREF/PPP2R3C/DAZAP1/PPP2CA/ETF1	1.18870459474689
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/712	28/9376	1.88121990369181	ECHS1/ACOT4/MECR/ACAA2	1.33866027193
Organismal Systems	Immune system	hsa04611	Platelet activation	13/712	126/9376	1.35865881933298	ACTG1/MYL12B/RHOA/MYL12A/ACTB/LYN/PPP1CA/VAMP8/FCGR2A/RAP1A/LCP2/FERMT3/AKT1	1.16188283009115
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/712	70/9376	1.50497592295345	RAC1/RBX1/TGFB1/CDC42/EGLN3/RAP1A/FH/AKT1	1.21563887719144
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/712	196/9376	1.27654207750516	CALM1/UBA52/RPS27A/GNG11/RAC1/CALM2/LYN/CYCS/UBC/HLA-F/PREX1/HLA-B/UBB/HLA-A/CALM3/HCK/CDK4/HLA-C/AKT1	1.12159051886259
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/712	173/9376	1.29401831525622	ACTG1/SLC25A6/VDAC1/MX1/SLC25A5/ACTB/RAB11A/CCL5/CYCS/OAS2/RAB11B/CDK4/MX2/KPNA2/HLA-DPA1/NFKBIB/AKT1	1.11892026233108
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/712	71/9376	1.48377907896819	RAC1/LYN/CDC42/CCL5/ATP6V1F/ATP6V0E1/ATP6V0D1/ATP6V1D	1.17296345717755
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/712	39/9376	1.68827427254394	HLA-F/HLA-B/HLA-A/HLA-C/HLA-DPA1	1.23468614116319
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/712	19/9376	2.07924305144885	GCSH/LIPT2/PDHA1	1.34987688345135
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/712	31/9376	1.69916636462486	ALDOA/TALDO1/PFKP/GPI	1.11773315746651
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/712	181/9376	1.23682413557639	CALM1/RHOA/CALM2/TGFB1/CYCS/CEBPB/FCGR3A/CTSS/FCGR2A/ATP6V0D1/CORO1A/CALM3/RIPK2/NFYB/IL10RA/HLA-DPA1/AKT1	0.922265142661909
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/712	87/9376	1.36226268888028	RHOA/RAC1/TGFB1/CYCS/RALB/BIRC5/RAC2/RALA/AKT1	0.973117234865565
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/712	195/9376	1.21555747623163	ACTG1/SLC25A6/VDAC1/RAC1/HMGB1/VDAC2/SLC25A5/ACTB/CYBA/NCF1/FCGR3A/FCGR2A/NCF2/CYBB/NCF4/HDAC3/RAC2/AKT1	0.871970546186366
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/712	100/9376	1.31685393258427	PPBP/PF4/CCL5/CCL3L3/TNFRSF1B/CXCR4/CSF1R/CCL3/TNFRSF14/IL10RA	0.913156352941091
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/712	77/9376	1.36815992995768	RAC1/TGFB1/CDC42/RALB/CDK4/RAC2/RALA/AKT1	0.92988698802437
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/712	12/9376	2.19475655430712	VKORC1/COQ5	1.18715043344868
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/712	33/9376	1.59618658495063	VAMP8/STX11/SNAP29/STX18	0.983472924973611
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/712	44/9376	1.49642492339122	GTF2F1/GTF2F2/TBPL1/TAF9/GTF2A2	0.946147756373901
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/712	44/9376	1.49642492339122	HLA-F/HLA-B/HLA-A/HLA-C/HLA-DPA1	0.946147756373901
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/712	45/9376	1.46317103620474	HLA-F/HLA-B/HLA-A/HLA-C/HLA-DPA1	0.892791339834858
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/712	68/9376	1.35558493060145	EIF4EBP1/CSF1R/BCL2A1/SPI1/CCNA2/PIM1/AKT1	0.843598948801483
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/712	13/9376	2.02592912705272	XRCC6/XRCC4	1.06107953323878
NA	NA	hsa04517	IgSF CAM signaling	26/712	299/9376	1.14509037616023	DYNLL1/ACTG1/MYL6/MYL12B/ARPC3/RHOA/MYL12A/TUBA1B/TUBA1C/RAC1/ARPC2/TUBB4B/ACTB/LYN/CDC42/TUBB6/TUBA4A/MYL9/TUBB/ESAM/RAP1A/ARPC5/CD48/LCP2/ARPC1A/AKT1	0.730919328068523
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/712	128/9376	1.23455056179775	NME1/APRT/RRM2/IMPDH2/AK2/GUK1/ADSL/HDDC3/GMPR2/NT5E/NUDT2/HPRT1	0.765920978564011
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/712	69/9376	1.33593877218694	RAC1/LYN/LCP2/ALOX5/ALOX5AP/RAC2/AKT1	0.80287185204304
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/712	227/9376	1.16022372914914	CALM1/RHOA/GNG11/RAC1/CALM2/CCL5/CYCS/EIF4EBP1/CCL3L3/HLA-F/HLA-B/CXCR4/HLA-A/CALM3/CDK4/HLA-C/CCL3/RAC2/IL10RA/AKT1	0.700518104028505
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/712	142/9376	1.20557050166166	RAC1/TGFB1/CYBA/NCF1/FCGR3A/FCGR2A/NCF2/CSF1R/LCP2/SPI1/FOSL1/NCF4/AKT1	0.707581461579742
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/712	36/9376	1.46317103620474	UGP2/AKR1B1/AKR1A1/CRYL1	0.798152023482195
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/712	36/9376	1.46317103620474	UGP2/PYGL/GYG1/GPI	0.798152023482195
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/712	180/9376	1.1705368289638	SRSF3/SRSF9/CCL5/CYCS/PPP1CA/EIF4EBP1/HLA-F/HLA-B/EIF2B3/ALYREF/HLA-A/OAS2/HLA-C/TNFRSF14/HLA-DPA1/AKT1	0.662249086219298
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/712	168/9376	1.17576243980738	PPIA/FTH1/SLC25A6/VDAC1/HMGB1/VDAC2/HSP90AB1/SLC25A5/PYGL/CHMP2A/CHMP4A/CYBB/SHARPIN/FTL/PPID	0.658968221304708
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/712	110/9376	1.19713993871297	ANAPC11/HSP90AB1/CDK1/ANAPC10/MAD2L1/CCNB1/CCNA2/CCNB2/ANAPC15/AKT1	0.59619897501702
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/712	174/9376	1.13521890740023	SKP1/CRYAB/RBX1/HSP90AB1/SEC61B/SEC61G/DNAJA1/HERPUD1/DERL3/UBE2J2/UBE2D2/UBE2D1/UBE2D3/DNAJA2/HSPBP1	0.516104142929748
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/712	39/9376	1.35061941803515	TYMS/GCSH/MTHFD2/SHMT2	0.628971550353955
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/712	63/9376	1.25414660246121	PTGES3/GPX4/HPGD/CYP2J2/ALOX5/LTA4H	0.580197956303481
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	21/712	250/9376	1.10615730337079	CLTA/CLTB/CD63/VPS29/LAMTOR5/ATP6V1F/LAPTM5/AP2S1/VAMP8/SNAP29/CTSS/AP3S1/RRAGD/ATP6V0E1/ATP6V0D1/ATP6V1D/LITAF/LAMTOR2/SLC11A1/BLOC1S1/AP1S2	0.487692484796657
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/712	28/9376	1.41091492776886	AKR1B1/ALPP/QDPR	0.624220454670454
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/712	52/9376	1.26620570440795	CYP11A1/CYP2J2/HSD3B1/ACOT4/ALOX5	0.551803321281294
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/712	41/9376	1.28473554398465	SSBP1/RPA2/RPA3/RAD51C	0.523772707441823
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/712	29/9376	1.36226268888028	CALM1/CALM2/CALM3	0.56008365289293
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/712	78/9376	1.18179199078075	CALM1/CFL1/RHOA/CALM2/LY96/CALM3/CFL2	0.462161420309043
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/712	54/9376	1.21930919683729	HLA-F/HLA-B/HLA-A/HLA-C/HLA-DPA1	0.46330350764141
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/712	79/9376	1.16683259849239	CLTA/CLTB/ATP6V1F/AP2S1/ATP6V0E1/ATP6V0D1/ATP6V1D	0.426863929098544
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/712	30/9376	1.31685393258427	TYMS/FOLR2/SHMT2	0.498279768380548
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/712	18/9376	1.46317103620474	OLAH/MECR	0.563835659144113
NA	NA	hsa04981	Folate transport and metabolism	3/712	31/9376	1.27437477346865	TYMS/FOLR2/SHMT2	0.438633488959124
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/712	158/9376	1.08348741288579	RPS6/RHOA/LAMTOR5/ATP6V1F/EIF4EBP1/RRAGD/TBC1D7/EIF4B/NPRL2/SGK1/ATP6V1D/LAMTOR2/AKT1	0.303387447495712
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/712	57/9376	1.15513502858269	SCD/ECHS1/MECR/ACAA2/ACAT1	0.336766633285212
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/712	32/9376	1.23455056179775	UGP2/AKR1B1/PFKP	0.380988147469038
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/712	83/9376	1.1105997021795	CCL5/POLR2E/POLR2H/POLR3D/DDX41/POLR2L/NFKBIB	0.290122524844896
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/712	136/9376	1.06510244547257	EIF3H/CSNK2B/MX1/CCNE1/CYCS/OAS2/RAB9A/CDK4/MX2/NFKBIB/AKT1	0.219228586778653
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/712	203/9376	1.03791442962307	CAV1/ACTG1/MYL12B/RHOA/MYL12A/RAC1/ACTB/CDC42/PPP1CA/MYL9/FLNA/PARVA/RAP1A/PARVG/RAC2/AKT1	0.156553673371272
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/712	60/9376	1.09737827715356	HSPB1/RAC1/CDC42/RAC2/AKT1	0.216914900059109
NA	NA	hsa04382	Cornified envelope formation	17/712	217/9376	1.03163672137938	KRT19/KRT8/KRT18/S100A10/S100A11/S100A9/S100A6/KRT23/S100A16/S100A13/KRT10/BLMH/PPP2R3C/COL17A1/PKP3/ABHD5/PPP2CA	0.135164835555609
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/712	61/9376	1.07938846933137	FTH1/MT2A/HMOX2/FTL/SLC39A4	0.178318880770277
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	23/712	298/9376	1.01636377347108	CSH1/CSH2/INHBA/PPBP/EBI3/GH2/LEP/CSHL1/PF4/TGFB1/CCL5/CCL3L3/TNFRSF1B/IL7R/LTB/CXCR4/INHA/CSF1R/IL32/TNFSF13B/CCL3/TNFRSF14/IL10RA	0.0822930037843846
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/712	101/9376	1.04305261986873	RAC1/SERPINE1/TGFB1/CDC42/CYBB/CDK4/PIM1/AKT1	0.124700939520801
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/712	89/9376	1.03572781214493	TUBA1B/TUBA1C/TUBB4B/TUBB6/CDK1/TUBA4A/TUBB	0.0970800778645637
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/712	23/9376	1.14509037616023	GGPS1/ACAT1	0.199707084130469
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/712	50/9376	1.05348314606742	TGFB1/CXCR4/TNFSF13B/HLA-DPA1	0.108697775388237
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/712	117/9376	1.01296456352636	ACTG1/MORF4L2/ACTB/MORF4L1/POLE3/BCL7C/CDK2AP2/VPS72/RUVBL2	0.0404515532429129
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/712	37/9376	1.06771940479806	NIT2/ADSL/RIMKLA	0.118312387916527
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/712	37/9376	1.06771940479806	MIF/COMT/GSTZ1	0.118312387916527
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/712	91/9376	1.01296456352636	RAC1/LYN/PIK3AP1/DAPP1/RAC2/NFKBIB/AKT1	0.0356249329342819
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/712	10/9376	1.31685393258427	MPST	0.287374638632165
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/712	212/9376	0.993852024591902	ACTG1/PFN1/CALM1/RHOA/RAC1/CALM2/ACTB/CDC42/RALB/CSF1R/RAP1A/LCP2/CALM3/RAC2/RALA/AKT1	-0.025955172828155
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/712	333/9376	0.988629078516719	PKM/MX1/ISG15/CDC42/HES2/CCNE1/ATP6V1F/PSMC1/EIF4EBP1/HLA-F/HLA-B/ATP6V0E1/ATP6V0D1/TBPL1/HLA-A/PPP2R3C/CCNA2/CDK4/HLA-C/MX2/CRB3/ATP6V1D/TADA3/AKT1/PPP2CA	-0.0605658651504354
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/712	38/9376	1.03962152572442	NAMPT/NT5E/NAPRT	0.0701556207700492
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/712	38/9376	1.03962152572442	PTPRC/IL7R/UNG	0.0701556207700492
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/712	52/9376	1.01296456352636	VDAC1/VDAC2/LPL/TSPO	0.026873538374089
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/712	53/9376	0.993852024591902	CLTA/CLTB/RAB11A/AP2S1	-0.0128664467681319
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/712	67/9376	0.982726815361395	CALM1/CALM2/PPP1CA/RAP1A/CALM3	-0.0406747333724128
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/712	122/9376	0.971449622398232	LEP/SCD/PFKP/EIF4EBP1/PPP2R3C/RAB11B/CCNA2/AKT1/PPP2CA	-0.0909899523253809
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/712	122/9376	0.971449622398232	RHOA/CDC42/PTPRC/LCP2/PPP2R3C/CDK4/NFKBIB/AKT1/PPP2CA	-0.0909899523253809
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/712	122/9376	0.971449622398232	ACTG1/ACTB/PFKP/MED30/HDAC3/MED27/DIO2/MED4/AKT1	-0.0909899523253809
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/712	204/9376	0.96827495042961	CAV1/ACTG1/RPS6/RHOA/RAC1/ACTB/IGF2/TGFB1/CDC42/CD63/PPP1CA/FLNA/EIF4B/HPSE/AKT1	-0.131326322578074
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/712	54/9376	0.975447357469829	RPA2/RPA3/UBE2T/RAD51C	-0.0518688936448638
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/712	137/9376	0.961207250061511	ACTG1/TUBA1B/TUBA1C/ACTB/CYCS/TUBA4A/BIRC5/CTSS/BCL2A1/AKT1	-0.131118743921233
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/712	233/9376	0.960794714761055	ENO1/ACTG1/PDLIM2/PDLIM4/ACTB/CSRP2/TPM4/CAPZB/FHL1/MYL9/TPM3/VCAN/TNNI2/TPM1/EMD/VIM/PDLIM1	-0.1737179244147
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/712	138/9376	0.954241980133529	CALM1/RPS6/CALM2/PYGL/PPP1CA/EIF4EBP1/TRIP10/SH2B2/CALM3/AKT1	-0.15523305337562
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/712	83/9376	0.951942601868147	SKP1/CSNK2B/UBE2D2/UBE2D1/AURKB/UBE2D3	-0.126063030991356
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/712	83/9376	0.951942601868147	PRDX1/ECH1/SOD1/PRDX5/PXMP2/MPV17	-0.126063030991356
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/712	27/9376	0.975447357469829	ECHS1/ACAT1	-0.0366238465963963
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/712	27/9376	0.975447357469829	SCD/ACOT4	-0.0366238465963963
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/712	112/9376	0.940609951845907	TGFB1/CYCS/LY96/ALOX5/IL10RA/HLA-DPA1/NFKBIB/AKT1	-0.181254930362524
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/712	56/9376	0.940609951845907	ALG3/ALG13/DPM2/DPM1	-0.127780960395195
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/712	42/9376	0.940609951845907	ECHS1/KYNU/ACAT1	-0.110578536439243
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/712	154/9376	0.940609951845907	CALM1/CALM2/TPM4/PPP1CA/TPM3/CREM/PPP2R3C/CALM3/TPM1/AKT1/PPP2CA	-0.213023684517864
NA	NA	hsa04518	Integrin signaling	11/712	154/9376	0.940609951845907	ACTG1/RAC1/ACTB/TGFB1/CDC42/FLNA/PARVA/PARVG/FERMT3/RAC2/AKT1	-0.213023684517864
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/712	99/9376	0.931108841221201	KRT19/KRT18/KRT23/KRT10/FCGR3A/FCGR2A/HLA-DPA1	-0.197534847773692
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/712	99/9376	0.931108841221201	ACTG1/ACTB/TGFB1/TPM4/TPM3/TPM1/EMD	-0.197534847773692
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/712	169/9376	0.935044212485872	UBA52/RPS27A/HMGB1/UBC/VAMP8/SNAP29/RRAGD/UBB/RAB1A/ATG5/AKT1/PPP2CA	-0.244269107948423
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/712	43/9376	0.918735301802979	ECHS1/ACAA2/ACAT1	-0.153105902872169
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/712	156/9376	0.928550849899164	YWHAE/MX1/EIF3E/CYCS/YWHAQ/OAS2/YWHAH/CDK4/MX2/AKT1/PPP2CA	-0.257964722588529
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/712	103/9376	0.894949274571834	SERPINE1/TGFB1/CCL5/CCL3L3/CCL3/AKT1/PPP2CA	-0.307308060333224
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/712	30/9376	0.877902621722846	DPM2/PIGH	-0.19200851594806
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/712	75/9376	0.877902621722846	GSTO1/GSTP1/CYCS/BIRC5/AKT1	-0.304325652196774
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/712	133/9376	0.891104164906649	CALM1/GNG11/CALM2/COMT/PPP1CA/PPP2R3C/CALM3/AKT1/PPP2CA	-0.36257430812942
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/712	76/9376	0.866351271437019	PLIN2/SCD/UBC/LPL/FABP5	-0.335348653293265
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/712	76/9376	0.866351271437019	ACTG1/CALM1/CALM2/ACTB/CALM3	-0.335348653293265
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/712	76/9376	0.866351271437019	CALM1/CALM2/CALM3/CDK4/AKT1	-0.335348653293265
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/712	105/9376	0.877902621722846	CSNK2B/UBE2I/LYN/LTB/LY96/BCL2A1/TNFSF13B	-0.36066509282045
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/712	105/9376	0.877902621722846	UBA52/RPS27A/CSNK2B/BNIP3L/UBC/MTX1/UBB	-0.36066509282045
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/712	105/9376	0.877902621722846	ACTG1/ACTB/TGFB1/TPM4/TPM3/TPM1/EMD	-0.36066509282045
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/712	62/9376	0.849583182312432	CRYAB/SOD1/ATG5/AKT1	-0.340635994569496
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/712	32/9376	0.823033707865168	LDHA/ECHS1	-0.28745213521616
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/712	32/9376	0.823033707865168	ATG5/PPP2CA	-0.28745213521616
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/712	32/9376	0.823033707865168	CYCS/BIRC5	-0.28745213521616
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/712	48/9376	0.823033707865168	ECHS1/ACAA2/ACAT1	-0.352357333428445
NA	NA	hsa03272	Virion - Hepatitis viruses	3/712	48/9376	0.823033707865168	CD63/CHMP4A/CD9	-0.352357333428445
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/712	16/9376	0.823033707865168	MIF	-0.203085553828864
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/712	166/9376	0.872614051712468	CALM1/RHOA/SLC25A6/VDAC1/CALM2/VDAC2/SLC25A5/PPP1CA/MYL9/CALM3/AKT1	-0.474692277557761
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/712	33/9376	0.798093292475315	IDH3B/PDHA1	-0.333066501718647
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/712	65/9376	0.810371650821089	AKR1B1/AGPAT2/LPL/AKR1A1	-0.439772625631744
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/712	139/9376	0.852639236925067	KRT19/CALM1/KRT18/KRT23/CALM2/HSP90AB1/KRT10/CALM3/AKT1	-0.501753260470122
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/712	17/9376	0.774619960343688	SEPHS1	-0.266619310661847
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/712	110/9376	0.837997957099081	SKP1/RHOA/INHBA/RBX1/TGFB1/TGIF1/PPP2CA	-0.489933458226422
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/712	34/9376	0.774619960343688	SKP1/RBX1	-0.377399561501
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/712	50/9376	0.790112359550562	SMS/P4HA1/GAMT	-0.426570261397536
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/712	183/9376	0.863510775465095	RAN/CSNK2B/SNU13/NOP10/NHP2/RPP38/EIF6/UTP14A/FBL/IMP3/RPP25L/GAR1	-0.53451721180857
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/712	157/9376	0.838760466614185	ACTG1/YWHAE/SERPINE1/ACTB/TGFB1/PPP1CA/YWHAQ/BIRC5/YWHAH/PPP2CA	-0.584044400617989
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/712	98/9376	0.806237101582206	CALM1/CYP11A1/CALM2/HSD3B1/CALM3/ATF1	-0.552742539154287
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/712	19/9376	0.693081017149616	HPSE	-0.383882795896576
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/712	69/9376	0.763393584106823	CALM1/CALM2/PPP1CA/CALM3	-0.565473970440396
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/712	37/9376	0.711812936532038	TPM3/TFG	-0.503490834676161
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/712	70/9376	0.752487961476726	LEP/TNFRSF1B/NFKBIB/AKT1	-0.595840797402795
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/712	133/9376	0.792092591028132	TGFB1/PRMT1/IL7R/CCNB1/HOMER3/SGK1/CCNB2/AKT1	-0.692238457956945
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/712	133/9376	0.792092591028132	RAC1/FCGR3A/HLA-B/CD48/LCP2/HLA-A/HLA-C/RAC2	-0.692238457956945
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/712	72/9376	0.731585518102372	ISG15/PIN1/NFKBIB/ATG5	-0.655395951587293
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/712	56/9376	0.70545746388443	EEF1A1/CYCS/RAB1A	-0.633724492770762
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/712	21/9376	0.627073301230605	CHST15	-0.490430692133211
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/712	168/9376	0.783841626538256	CSH1/CSH2/GH2/LEP/CSHL1/FHL1/IL7R/PIM1/IL10RA/AKT1	-0.810420582670022
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/712	184/9376	0.787249633610161	CFL1/MYL12B/RHOA/MYL12A/RAC1/CDC42/MYL9/EFNB1/CXCR4/RAC2/CFL2	-0.835488802205275
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/712	154/9376	0.769589960601196	ACTG1/CALM1/MYL6/RHOA/CALM2/ACTB/PPP1CA/MYL9/CALM3	-0.826448151974711
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/712	23/9376	0.572545188080117	MDH1	-0.5883626215965
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	23/712	362/9376	0.836675150536967	CSH1/RPS6/CSH2/GNG11/GH2/YWHAE/RAC1/CSHL1/HSP90AB1/IGF2/CCNE1/YWHAQ/EIF4EBP1/PIK3AP1/IL7R/CSF1R/PPP2R3C/YWHAH/EIF4B/SGK1/CDK4/AKT1/PPP2CA	-0.908477526041832
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/712	60/9376	0.658426966292135	CRH/LYN/PPP2CA	-0.760870726361182
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/712	93/9376	0.70798598526036	CKS1B/CCNE1/CYCS/CDK4/AKT1	-0.811273719222755
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/712	109/9376	0.724873724358314	RAC1/CCL5/CCL3L3/LY96/CCL3/AKT1	-0.828213203617507
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/712	201/9376	0.786181452289116	HPGD/IGFBP3/CEBPB/CSF1R/LYL1/ETV4/LMO2/BCL2A1/SPI1/ATF1/CCNA2/MLLT1	-0.878429234560202
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/712	125/9376	0.737438202247191	RHOA/RAC1/ORMDL2/PPP2R3C/RAC2/AKT1/PPP2CA	-0.847146686617891
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/712	43/9376	0.612490201201986	AGPAT2/ACAT1	-0.730083774789153
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/712	44/9376	0.598569969356486	ALG3/ALG13	-0.765094790648031
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/712	160/9376	0.740730337078652	HLA-F/PTPRC/CD99/HLA-B/ESAM/HLA-A/VCAN/HLA-C/HLA-DPA1	-0.948215116424315
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/712	238/9376	0.774619960343688	CALM1/RHOA/GNG11/RAC1/CALM2/IGF2/CDC42/RALB/CSF1R/RAP1A/CALM3/RAC2/RALA/AKT1	-1.0095893621526
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/712	99/9376	0.665077743729429	CALM1/CALM2/CYP2J2/PPP1CA/CALM3	-0.96033827970373
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/712	99/9376	0.665077743729429	RAC1/EIF4EBP1/WAS/RAC2/AKT1	-0.96033827970373
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/712	66/9376	0.598569969356486	CYP11A1/HSD3B1/COMT	-0.938152411095544
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/712	134/9376	0.687908770752977	CALM1/MYL6/RHOA/CALM2/PPP1CA/MYL9/CALM3	-1.04307946142195
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/712	50/9376	0.526741573033708	TGFB1/GYPC	-0.961838298183308
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/712	69/9376	0.572545188080117	CALM1/CALM2/CALM3	-1.02158924460154
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/712	30/9376	0.438951310861423	CYP2J2	-0.882296800276668
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/712	105/9376	0.627073301230605	CALM1/RHOA/CALM2/CALM3/AKT1	-1.10159320637973
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/712	122/9376	0.647633081598821	CSH1/CSH2/GH2/CSHL1/IGFBP3/AKT1	-1.12299212128034
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/712	106/9376	0.621157515369939	GSTP1/HSP90AB1/CCNE1/FOLR2/AKT1	-1.12444483790228
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/712	31/9376	0.424791591156216	AKR1A1	-0.919565848055653
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/712	31/9376	0.424791591156216	ECHS1	-0.919565848055653
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/712	140/9376	0.658426966292135	CALM1/RPS6/GNG11/CALM2/SERPINE1/CALM3/AKT1	-1.16727194061164
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/712	90/9376	0.585268414481898	CSNK2B/BATF3/NFKBIB/AKT1	-1.13328839168359
Human Diseases	Immune disease	hsa05310	Asthma	1/712	32/9376	0.411516853932584	HLA-DPA1	-0.955892417901358
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/712	109/9376	0.604061436965261	EBI3/HSP90AB1/TGFB1/HLA-DPA1/NFKBIB	-1.19189468531092
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/712	143/9376	0.644613813153139	SNRPD1/SNRPB/SSB/SNRPD3/FCGR3A/FCGR2A/HLA-DPA1	-1.2276188766445
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/712	93/9376	0.566388788208288	CALM1/CALM2/CDC42/CALM3	-1.2046592380184
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/712	93/9376	0.566388788208288	CALM1/CALM2/CALM3/LYZ	-1.2046592380184
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/712	178/9376	0.66582502209317	SKP1/RHOA/CSNK2B/RAC1/CACYBP/RBX1/CBY1/FOSL1/RAC2	-1.29033845302023
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/712	94/9376	0.560363375567774	S100A9/HSP90AB1/CEBPB/FOSL1	-1.22801429579179
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/712	163/9376	0.646308678568967	TGFB1/CCNE1/CYCS/YWHAQ/BIRC5/PCNA/CCNA2/AKT1	-1.30582230751989
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/712	77/9376	0.513059973734131	TGFB1/CDK4/AKT1	-1.22989808919434
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/712	97/9376	0.543032549519286	CALM1/GNG11/CALM2/CALM3	-1.2968416784797
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/712	115/9376	0.572545188080117	NACA/RHOA/GCM1/OXSR1/SGK1	-1.32213743386617
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/712	59/9376	0.446391163587888	ABHD5/AKT1	-1.22280550371169
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/712	98/9376	0.537491401054804	CALM1/CALM2/CALM3/IMPA2	-1.31938662896355
NA	NA	hsa04519	Cadherin signaling	23/712	404/9376	0.749694070530649	KRT19/ACTG1/KRT8/KRT18/ARPC3/RHOA/YWHAE/RAC1/ARPC2/KRT23/ACTB/CDC42/PPP1CA/YWHAQ/KRT10/BRK1/ARPC5/ARPC1A/PKP3/YWHAH/VIM/RAC2/MYO1F	-1.47429231257289
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/712	80/9376	0.493820224719101	RPS6/EIF4EBP1/AKT1	-1.30337125250322
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/712	38/9376	0.346540508574808	SGK1	-1.15704419329708
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/712	170/9376	0.61969596827495	GSTO1/ACTG1/GSTP1/ACTB/IGF2/TGFB1/CDK4/AKT1	-1.43445298361461
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/712	100/9376	0.526741573033708	IL7R/CSF1R/CD9/HLA-DPA1	-1.36390587183967
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/712	155/9376	0.594708227618702	CRH/CYP11A1/HSD3B1/CCNE1/RAP1A/CDK4/FH	-1.45851546605181
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/712	102/9376	0.516413306895792	RHOA/RAC1/RAB11A/RAP1A	-1.40769087412492
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/712	63/9376	0.41804886748707	ECHS1/ACAT1	-1.32855153081983
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/712	103/9376	0.511399585469619	PRDX1/SERPINB9/HSPB1/TGFB1	-1.42931755164331
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/712	157/9376	0.587132326629929	RAC1/TGFB1/UQCRFS1/CEBPB/RAB17/ALOX5/SGK1	-1.49549584871956
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/712	41/9376	0.321183885996163	CDK4	-1.24868623323715
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/712	226/9376	0.640946604355175	CALM1/CRH/RHOA/RAC1/CALM2/PPP1CA/MYL9/RAP1A/CALM3/RAC2/AKT1	-1.56627899608405
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/712	65/9376	0.405185825410544	CYP11A1/HSD3B1	-1.37945087037268
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/712	65/9376	0.405185825410544	KISS1/AKT1	-1.37945087037268
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/712	86/9376	0.459367650901489	ACTG1/ACTB/EMD	-1.44380921812156
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/712	66/9376	0.399046646237657	TGFB1/HLA-DPA1	-1.40444360100393
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/712	88/9376	0.448927477017365	SERPINE1/F13A1/SERPINA1	-1.48886528256723
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/712	90/9376	0.438951310861423	EIF4EBP1/ATG5/AKT1	-1.53311199043529
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/712	70/9376	0.376243980738363	GSTO1/GSTP1	-1.50158063469991
NA	NA	hsa04081	Hormone signaling	10/712	219/9376	0.601303165563593	CSH1/CSH2/CRH/RHOA/GNG11/GH2/LEP/CSHL1/IGF2/DIO2	-1.71141230808744
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/712	47/9376	0.280181687783887	PKM	-1.41814515828954
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/712	48/9376	0.274344569288389	AKT1	-1.44485149950817
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/712	73/9376	0.360781899338156	GSTO1/GSTP1	-1.57168459761173
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/712	73/9376	0.360781899338156	CDK4/AKT1	-1.57168459761173
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/712	73/9376	0.360781899338156	CDK4/AKT1	-1.57168459761173
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/712	75/9376	0.351161048689139	GPX1/GPX3	-1.61722012228739
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/712	119/9376	0.44263997733925	CCL5/CEBPB/TNFRSF1B/AKT1	-1.75404437896106
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/712	78/9376	0.337654854508787	TPI1/IMPA2	-1.68384961218778
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/712	101/9376	0.391144732450773	CALM1/CALM2/CALM3	-1.76353550903706
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/712	79/9376	0.333380742426397	GSTO1/GSTP1	-1.70563617705446
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/712	149/9376	0.441897292813513	RHOA/RALB/AGPAT2/RALA/AKT1	-1.9685362484631
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/712	59/9376	0.223195581793944	AKT1	-1.71579760909527
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/712	86/9376	0.306245100600993	EIF4EBP1/AKT1	-1.85273730019949
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/712	109/9376	0.362436862179157	PYGL/PPP1CA/AKT1	-1.91925764869774
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/712	191/9376	0.482616624507324	CALM1/CRH/GNG11/CALM2/PPP1CA/CALM3/HDAC3	-2.07088501912438
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/712	115/9376	0.34352711284807	GNG11/CYP2J2/ALOX5	-2.03050089557642
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/712	93/9376	0.283194394104144	HLA-DPA1/NFKBIB	-1.99143027560968
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/712	68/9376	0.193654990085922	RDH13	-1.91299389876916
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/712	71/9376	0.185472384871024	AKT1	-1.97489136869246
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/712	99/9376	0.266031097491772	CDK4/AKT1	-2.10454342759879
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/712	103/9376	0.25569979273481	SLC7A7/COL17A1	-2.17732387918337
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/712	130/9376	0.303889369057908	GNG11/TGFB1/AKT1	-2.29107555267743
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/712	217/9376	0.424791591156216	GSTO1/PTGES3/HSP90AB1/EIF4EBP1/BIRC5/KPNA2/AKT1	-2.4575223538253
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/712	300/9376	0.482846441947566	HSPB1/RAC1/STMN1/IGF2/TGFB1/CDC42/FLNA/CSF1R/RAP1A/RAC2/AKT1	-2.60975245001282
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/712	115/9376	0.229018075232047	GNG11/AKT1	-2.38468262643154
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/712	116/9376	0.227043781480047	GNG11/HOMER3	-2.4012910929973
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/712	144/9376	0.274344569288389	SCD/LY96/AKT1	-2.51553411313537
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/712	89/9376	0.147961116020704	GNG11	-2.31517118554042
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/712	254/9376	0.41475714412103	CALM1/SLC25A6/VDAC1/CALM2/VDAC2/SLC25A5/CXCR4/CALM3	-2.71065570182169
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/712	91/9376	0.144709223360909	GNG11	-2.35022771843592
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/712	150/9376	0.263370786516854	TGFB1/CCNE1/AKT1	-2.60707938687771
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/712	104/9376	0.126620570440795	AGPAT2	-2.56743424890049
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/712	144/9376	0.182896379525593	INHBA/AKT1	-2.83254550889823
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/712	148/9376	0.177953234133009	CDK4/AKT1	-2.88961513292546
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/712	323/9376	0.32615577277629	RHOA/STMN1/UBE2I/MARCKS/CCNE1/TPM1/PIM1/VIM	-3.53289659633115
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/712	370/9376	0.355906468266019	CSH1/CSH2/CRH/KISS1/GH2/LEP/CSHL1/NPB/TSPO/TMEM97	-3.62368336024106
NA	NA	hsa04082	Neuroactive ligand signaling	1/712	199/9376	0.0661735644514708	GNG11	-3.81688213963747
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/712	449/9376	0.087985786141488	CALM1/CALM2/CALM3	-5.67725528464567