ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 96/1182 175/18639 0.548571428571429 8.65044234952864 2.78684745615175e-68 2.82586332053787e-65 GO:0009055 electron transfer activity 42/1182 116/18639 0.362068965517241 5.70947838263609 1.86254621644375e-21 9.4431093173698e-19 GO:0045296 cadherin binding 61/1182 334/18639 0.182634730538922 2.87997355542722 5.1047604307976e-14 1.72540902560959e-11 GO:0019843 rRNA binding 24/1182 65/18639 0.369230769230769 5.82241311987505 4.58204940672326e-13 1.16154952460435e-10 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 23/1182 68/18639 0.338235294117647 5.33364437145417 1.16559186308101e-11 2.36382029832829e-09 GO:0022853 active monoatomic ion transmembrane transporter activity 28/1182 118/18639 0.23728813559322 3.74180504172761 8.62393874685737e-10 1.45744564821889e-07 GO:0031386 protein tag activity 10/1182 15/18639 0.666666666666667 10.5126903553299 2.27095670454352e-09 2.87843762300891e-07 GO:0141047 molecular tag activity 10/1182 15/18639 0.666666666666667 10.5126903553299 2.27095670454352e-09 2.87843762300891e-07 GO:0043021 ribonucleoprotein complex binding 34/1182 177/18639 0.192090395480226 3.02908027187473 5.39567830559425e-09 6.07913089096952e-07 GO:0043022 ribosome binding 25/1182 112/18639 0.223214285714286 3.51987400290065 2.56571221104495e-08 2.55310216819933e-06 GO:0044389 ubiquitin-like protein ligase binding 48/1182 322/18639 0.149068322981366 2.35066368193713 2.76963746057126e-08 2.55310216819933e-06 GO:0180051 translation factor activity 21/1182 84/18639 0.25 3.94225888324873 4.11338216663907e-08 3.47580793081002e-06 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/1182 15/18639 0.6 9.46142131979695 5.68787732731124e-08 4.28874219673932e-06 GO:0015078 proton transmembrane transporter activity 33/1182 185/18639 0.178378378378378 2.81285498696666 5.92134031107993e-08 4.28874219673932e-06 GO:0055106 ubiquitin-protein transferase regulator activity 13/1182 36/18639 0.361111111111111 5.69437394247039 1.47062114948583e-07 9.9413989705242e-06 GO:0008135 translation factor activity, RNA binding 20/1182 83/18639 0.240963855421687 3.79976759831203 1.66039665627808e-07 1.05227638091623e-05 GO:0031625 ubiquitin protein ligase binding 44/1182 302/18639 0.145695364238411 2.29747537566813 2.03085959928782e-07 1.2113480198105e-05 GO:0003743 translation initiation factor activity 15/1182 51/18639 0.294117647058824 4.63795162735145 3.6088626440067e-07 2.03299262279044e-05 GO:0061650 ubiquitin-like protein conjugating enzyme activity 13/1182 41/18639 0.317073170731707 4.99993809582766 8.32454029867993e-07 4.43624604265998e-05 GO:0048027 mRNA 5'-UTR binding 10/1182 24/18639 0.416666666666667 6.57043147208122 8.74999219459562e-07 4.43624604265998e-05 GO:1990948 ubiquitin ligase inhibitor activity 7/1182 11/18639 0.636363636363636 10.034840793724 1.06700717697195e-06 5.07239979020449e-05 GO:0004129 cytochrome-c oxidase activity 8/1182 15/18639 0.533333333333333 8.41015228426396 1.10052066454141e-06 5.07239979020449e-05 GO:0016209 antioxidant activity 19/1182 86/18639 0.22093023255814 3.48385668752213 1.40507808296413e-06 6.19456163532882e-05 GO:0004601 peroxidase activity 15/1182 57/18639 0.263157894736842 4.1497461928934 1.7418176043594e-06 7.35917937841848e-05 GO:0015399 primary active transmembrane transporter activity 28/1182 166/18639 0.168674698795181 2.65983731881842 1.86892171342067e-06 7.58034646963424e-05 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/1182 16/18639 0.5 7.88451776649746 2.07837456287859e-06 8.10566079522649e-05 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/1182 59/18639 0.254237288135593 4.00907683042244 2.79455555272776e-06 0.000104951086313554 GO:0008137 NADH dehydrogenase (ubiquinone) activity 12/1182 41/18639 0.292682926829268 4.61532747307168 5.65681555136458e-06 0.000204857534610132 GO:0098641 cadherin binding involved in cell-cell adhesion 8/1182 18/18639 0.444444444444444 7.00846023688663 6.30161361732636e-06 0.000218171494147358 GO:0061631 ubiquitin conjugating enzyme activity 11/1182 35/18639 0.314285714285714 4.95598259608412 6.4547779333538e-06 0.000218171494147358 GO:0016651 oxidoreductase activity, acting on NAD(P)H 18/1182 88/18639 0.204545454545455 3.22548454083987 8.3995825340899e-06 0.000274747635147328 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 14/1182 58/18639 0.241379310344828 3.8063189217574 1.14682101386901e-05 0.000363398908769741 GO:0003954 NADH dehydrogenase activity 12/1182 44/18639 0.272727272727273 4.30064605445316 1.26520165104664e-05 0.000388761961867058 GO:0004857 enzyme inhibitor activity 49/1182 416/18639 0.117788461538462 1.85741043537681 2.11558174439818e-05 0.000630941143770515 GO:0043023 ribosomal large subunit binding 7/1182 16/18639 0.4375 6.89895304568528 2.78940873527952e-05 0.000808131559306696 GO:0140313 molecular sequestering activity 13/1182 55/18639 0.236363636363636 3.72722658052607 2.98560571600558e-05 0.000840945610008237 GO:0051537 2 iron, 2 sulfur cluster binding 9/1182 28/18639 0.321428571428571 5.06861856417694 3.69735226218081e-05 0.00101327437671658 GO:0051082 unfolded protein binding 20/1182 121/18639 0.165289256198347 2.60645215421404 7.16445171903239e-05 0.00191177737976285 GO:0003779 actin binding 49/1182 443/18639 0.110609480812641 1.74420483322066 0.000104973675685448 0.00272931556782165 GO:0048306 calcium-dependent protein binding 15/1182 80/18639 0.1875 2.95669416243655 0.000132649546984555 0.00336266601605846 GO:0015036 disulfide oxidoreductase activity 10/1182 40/18639 0.25 3.94225888324873 0.000148953396554398 0.00364477251826474 GO:0043024 ribosomal small subunit binding 7/1182 20/18639 0.35 5.51916243654822 0.000150966909040551 0.00364477251826474 GO:0016859 cis-trans isomerase activity 10/1182 42/18639 0.238095238095238 3.7545322697607 0.000230284329575989 0.00543042581837332 GO:0140517 protein-RNA adaptor activity 7/1182 22/18639 0.318181818181818 5.01742039686202 0.00029692469852062 0.00684276464317975 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 9/1182 36/18639 0.25 3.94225888324873 0.00031815732654965 0.0068640750876882 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 9/1182 36/18639 0.25 3.94225888324873 0.00031815732654965 0.0068640750876882 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 9/1182 36/18639 0.25 3.94225888324873 0.00031815732654965 0.0068640750876882 GO:0051015 actin filament binding 27/1182 209/18639 0.129186602870813 2.03714813105676 0.000339839296225166 0.00717910513275662 GO:0004602 glutathione peroxidase activity 7/1182 23/18639 0.304347826086957 4.79927168395498 0.000403611741000295 0.00835229194641427 GO:0003925 G protein activity 11/1182 54/18639 0.203703703703704 3.21221094190637 0.000487697809600076 0.00989051157868953 GO:0004859 phospholipase inhibitor activity 5/1182 12/18639 0.416666666666667 6.57043147208122 0.000552924317808939 0.0108306896778829 GO:0005525 GTP binding 41/1182 378/18639 0.108465608465608 1.71039803400209 0.000555419983481172 0.0108306896778829 GO:0003924 GTPase activity 37/1182 331/18639 0.11178247734139 1.76270185716257 0.000576903606556863 0.0110373633405407 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 9/1182 39/18639 0.230769230769231 3.63900819992191 0.000603131226974611 0.0113254641509677 GO:0019211 phosphatase activator activity 7/1182 25/18639 0.28 4.41532994923858 0.000707769034510125 0.0130486872907867 GO:0019855 calcium channel inhibitor activity 5/1182 13/18639 0.384615384615385 6.06501366653651 0.000851736164129052 0.0154225084004796 GO:0019001 guanyl nucleotide binding 42/1182 400/18639 0.105 1.65574873096447 0.000921744574457824 0.0161146379051764 GO:0032561 guanyl ribonucleotide binding 42/1182 400/18639 0.105 1.65574873096447 0.000921744574457824 0.0161146379051764 GO:0044325 transmembrane transporter binding 19/1182 136/18639 0.139705882352941 2.20302702299194 0.000958974249166825 0.0164813540450027 GO:0016853 isomerase activity 23/1182 180/18639 0.127777777777778 2.01493231810491 0.00105176295990499 0.0175017414251631 GO:0015035 protein-disulfide reductase activity 8/1182 34/18639 0.235294117647059 3.71036130188116 0.00105286610151376 0.0175017414251631 GO:0032036 myosin heavy chain binding 5/1182 14/18639 0.357142857142857 5.63179840464104 0.0012560788558486 0.02054296709404 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 11/1182 61/18639 0.180327868852459 2.84359657152367 0.00141903360090155 0.0228396836716535 GO:0072542 protein phosphatase activator activity 6/1182 21/18639 0.285714285714286 4.50543872371284 0.00152524422223374 0.0241655881460158 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/1182 29/18639 0.241379310344828 3.8063189217574 0.00183940642323148 0.0286947402024112 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 10/1182 54/18639 0.185185185185185 2.92019176536943 0.00187513881262701 0.0288089508485422 GO:0070034 telomerase RNA binding 6/1182 22/18639 0.272727272727273 4.30064605445316 0.00198586404362616 0.0300547185109989 GO:0055102 lipase inhibitor activity 5/1182 16/18639 0.3125 4.92782360406091 0.00246382938487261 0.0354202351385236 GO:0005131 growth hormone receptor binding 4/1182 10/18639 0.4 6.30761421319797 0.00248011508366388 0.0354202351385236 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/1182 10/18639 0.4 6.30761421319797 0.00248011508366388 0.0354202351385236 GO:0097177 mitochondrial ribosome binding 4/1182 10/18639 0.4 6.30761421319797 0.00248011508366388 0.0354202351385236 GO:0019207 kinase regulator activity 31/1182 287/18639 0.10801393728223 1.70327561506217 0.00264622206633284 0.0372676274341874 GO:0051540 metal cluster binding 12/1182 77/18639 0.155844155844156 2.45751203111609 0.00319272748585155 0.0443482968582667 GO:0019887 protein kinase regulator activity 28/1182 255/18639 0.109803921568627 1.73150194087787 0.00328570296153143 0.0450230108512551 GO:0050786 RAGE receptor binding 4/1182 11/18639 0.363636363636364 5.73419473927088 0.00370287805940753 0.0500629113631898 GO:0140311 protein sequestering activity 7/1182 33/18639 0.212121212121212 3.34494693124135 0.00403400321533415 0.0538220955309057 GO:0005200 structural constituent of cytoskeleton 15/1182 112/18639 0.133928571428571 2.11192440174039 0.00472872578210075 0.0622717914681839 GO:0008200 ion channel inhibitor activity 8/1182 43/18639 0.186046511627907 2.93377405265022 0.00507066335630642 0.0659186236319835 GO:0070003 threonine-type peptidase activity 5/1182 19/18639 0.263157894736842 4.1497461928934 0.00559511619323447 0.0718157951891108 GO:0016860 intramolecular oxidoreductase activity 9/1182 53/18639 0.169811320754717 2.67776075088593 0.00568927638101892 0.0721115781294148 GO:0016248 channel inhibitor activity 8/1182 44/18639 0.181818181818182 2.86709736963544 0.00586042836730438 0.0733638810425511 GO:0017069 snRNA binding 9/1182 54/18639 0.166666666666667 2.62817258883249 0.0064521038946973 0.0797857725515008 GO:0141110 transporter inhibitor activity 8/1182 45/18639 0.177777777777778 2.80338409475465 0.00674031301413649 0.0823455107992097 GO:0098632 cell-cell adhesion mediator activity 9/1182 55/18639 0.163636363636364 2.5803876326719 0.00729107763939682 0.0874662618968538 GO:0019003 GDP binding 11/1182 75/18639 0.146666666666667 2.31279187817259 0.00741824311945703 0.0874662618968538 GO:0044183 protein folding chaperone 11/1182 75/18639 0.146666666666667 2.31279187817259 0.00741824311945703 0.0874662618968538 GO:0017022 myosin binding 11/1182 76/18639 0.144736842105263 2.28236040609137 0.00819027379752026 0.0943742912577903 GO:0051536 iron-sulfur cluster binding 11/1182 76/18639 0.144736842105263 2.28236040609137 0.00819027379752026 0.0943742912577903 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/1182 21/18639 0.238095238095238 3.7545322697607 0.00881141230607745 0.0992752453151393 GO:0070182 DNA polymerase binding 5/1182 21/18639 0.238095238095238 3.7545322697607 0.00881141230607745 0.0992752453151393 GO:0044548 S100 protein binding 4/1182 14/18639 0.285714285714286 4.50543872371284 0.00964059481439852 0.107423770789012 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1182 30/18639 0.2 3.15380710659898 0.0102436078067846 0.111873492828774 GO:0016247 channel regulator activity 19/1182 168/18639 0.113095238095238 1.78340282813633 0.0102605866203905 0.111873492828774 GO:0000287 magnesium ion binding 24/1182 230/18639 0.104347826086957 1.64546457735599 0.0113303242490289 0.122222859452291 GO:0141108 transporter regulator activity 19/1182 170/18639 0.111764705882353 1.76242161839355 0.0115615189000629 0.123404001733303 GO:0000049 tRNA binding 11/1182 80/18639 0.1375 2.1682423857868 0.0119177948292994 0.125881707884475 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1182 15/18639 0.266666666666667 4.20507614213198 0.012496670956999 0.130635302581412 GO:0061135 endopeptidase regulator activity 20/1182 184/18639 0.108695652173913 1.71402560141249 0.0130115206416572 0.134354305425437 GO:0008171 O-methyltransferase activity 5/1182 23/18639 0.217391304347826 3.42805120282498 0.0131174321865072 0.134354305425437 GO:0030515 snoRNA binding 6/1182 32/18639 0.1875 2.95669416243655 0.014038880044292 0.140944795692199 GO:0031369 translation initiation factor binding 6/1182 32/18639 0.1875 2.95669416243655 0.014038880044292 0.140944795692199 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/1182 128/18639 0.1171875 1.84793385152284 0.0156131139659365 0.151535139639394 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/1182 24/18639 0.208333333333333 3.28521573604061 0.0157239159553464 0.151535139639394 GO:0008142 oxysterol binding 4/1182 16/18639 0.25 3.94225888324873 0.0158409514810411 0.151535139639394 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/1182 16/18639 0.25 3.94225888324873 0.0158409514810411 0.151535139639394 GO:0097027 ubiquitin-protein transferase activator activity 4/1182 16/18639 0.25 3.94225888324873 0.0158409514810411 0.151535139639394 GO:0061134 peptidase regulator activity 23/1182 226/18639 0.101769911504425 1.60481335070302 0.0170440668286182 0.161520409011391 GO:0005507 copper ion binding 9/1182 63/18639 0.142857142857143 2.25271936185642 0.0173108444550268 0.162529595161085 GO:0051427 hormone receptor binding 6/1182 34/18639 0.176470588235294 2.78277097641087 0.0187168921615117 0.174118611484155 GO:0003725 double-stranded RNA binding 10/1182 75/18639 0.133333333333333 2.10253807106599 0.01964689286994 0.181108630637447 GO:0098631 cell adhesion mediator activity 10/1182 76/18639 0.131578947368421 2.0748730964467 0.021382744244549 0.188376147520669 GO:0001094 TFIID-class transcription factor complex binding 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0005528 FK506 binding 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0016868 intramolecular phosphotransferase activity 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0030957 Tat protein binding 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0050815 phosphoserine residue binding 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0098505 G-rich strand telomeric DNA binding 3/1182 10/18639 0.3 4.73071065989848 0.0218005997953928 0.188376147520669 GO:0008198 ferrous iron binding 5/1182 26/18639 0.192307692307692 3.03250683326825 0.0219214846227209 0.188376147520669 GO:0000400 four-way junction DNA binding 4/1182 18/18639 0.222222222222222 3.50423011844332 0.0240823526663575 0.203495880030721 GO:0003746 translation elongation factor activity 4/1182 18/18639 0.222222222222222 3.50423011844332 0.0240823526663575 0.203495880030721 GO:0022804 active transmembrane transporter activity 40/1182 457/18639 0.087527352297593 1.38022192848971 0.0243203114007351 0.203808229424342 GO:0099106 ion channel regulator activity 17/1182 160/18639 0.10625 1.67546002538071 0.0254379847595869 0.211427184805091 GO:0005536 D-glucose binding 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0008199 ferric iron binding 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0010854 adenylate cyclase regulator activity 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0015217 ADP transmembrane transporter activity 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0034511 U3 snoRNA binding 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0042608 T cell receptor binding 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0070990 snRNP binding 3/1182 11/18639 0.272727272727273 4.30064605445316 0.0285872454463874 0.221278373149899 GO:0008301 DNA binding, bending 4/1182 19/18639 0.210526315789474 3.31979695431472 0.0290122823925237 0.222867078378932 GO:0042162 telomeric DNA binding 6/1182 38/18639 0.157894736842105 2.48984771573604 0.0310369294706425 0.236627417167154 GO:0000217 DNA secondary structure binding 6/1182 39/18639 0.153846153846154 2.4260054666146 0.0347822384738741 0.259620006176802 GO:0001098 basal transcription machinery binding 8/1182 60/18639 0.133333333333333 2.10253807106599 0.034871523414234 0.259620006176802 GO:0001099 basal RNA polymerase II transcription machinery binding 8/1182 60/18639 0.133333333333333 2.10253807106599 0.034871523414234 0.259620006176802 GO:0005506 iron ion binding 16/1182 154/18639 0.103896103896104 1.63834135407739 0.0353180517752787 0.259620006176802 GO:0003713 transcription coactivator activity 24/1182 256/18639 0.09375 1.47834708121827 0.0358241000472936 0.259620006176802 GO:0005527 macrolide binding 3/1182 12/18639 0.25 3.94225888324873 0.0363570422851143 0.259620006176802 GO:0010853 cyclase activator activity 3/1182 12/18639 0.25 3.94225888324873 0.0363570422851143 0.259620006176802 GO:0043047 single-stranded telomeric DNA binding 3/1182 12/18639 0.25 3.94225888324873 0.0363570422851143 0.259620006176802 GO:0097371 MDM2/MDM4 family protein binding 3/1182 12/18639 0.25 3.94225888324873 0.0363570422851143 0.259620006176802 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/1182 30/18639 0.166666666666667 2.62817258883249 0.0385886939044925 0.271379298877115 GO:0061791 GTPase motor activity 6/1182 40/18639 0.15 2.36535532994924 0.0388067044745382 0.271379298877115 GO:1990606 membrane scission GTPase motor activity 6/1182 40/18639 0.15 2.36535532994924 0.0388067044745382 0.271379298877115 GO:0030414 peptidase inhibitor activity 17/1182 169/18639 0.100591715976331 1.5862343435557 0.040051136076037 0.278163369733572 GO:0030544 Hsp70 protein binding 7/1182 51/18639 0.137254901960784 2.16437742609734 0.0408969088705553 0.282105208127504 GO:0017080 sodium channel regulator activity 6/1182 41/18639 0.146341463414634 2.30766373653584 0.043115278430408 0.295397921138066 GO:0003684 damaged DNA binding 9/1182 74/18639 0.121621621621622 1.91785567293182 0.0438220194923213 0.296236851768092 GO:0048029 monosaccharide binding 9/1182 74/18639 0.121621621621622 1.91785567293182 0.0438220194923213 0.296236851768092 GO:0051087 protein-folding chaperone binding 14/1182 134/18639 0.104477611940299 1.64751117508902 0.04499254091027 0.296895574112305 GO:0019104 DNA N-glycosylase activity 3/1182 13/18639 0.230769230769231 3.63900819992191 0.0450906493227761 0.296895574112305 GO:0030955 potassium ion binding 3/1182 13/18639 0.230769230769231 3.63900819992191 0.0450906493227761 0.296895574112305 GO:0031432 titin binding 3/1182 13/18639 0.230769230769231 3.63900819992191 0.0450906493227761 0.296895574112305 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/1182 122/18639 0.10655737704918 1.68030706499126 0.0456338532407039 0.298533723781121 GO:0061133 endopeptidase activator activity 4/1182 22/18639 0.181818181818182 2.86709736963544 0.0471442918223499 0.306437896845274 GO:0008307 structural constituent of muscle 6/1182 42/18639 0.142857142857143 2.25271936185642 0.0477119838614367 0.308152558187878 GO:0005246 calcium channel regulator activity 7/1182 53/18639 0.132075471698113 2.08270280624461 0.0488892695457687 0.313681597862318 GO:0051059 NF-kappaB binding 5/1182 32/18639 0.15625 2.46391180203046 0.049186759428115 0.313681597862318 GO:0004866 endopeptidase inhibitor activity 16/1182 161/18639 0.0993788819875776 1.56710912129142 0.0497168873171544 0.315080773372466 GO:0016829 lyase activity 19/1182 200/18639 0.095 1.49805837563452 0.0510617461324682 0.321593854523744 GO:0005347 ATP transmembrane transporter activity 3/1182 14/18639 0.214285714285714 3.37907904278463 0.0547588460068791 0.335818634222768 GO:0016530 metallochaperone activity 3/1182 14/18639 0.214285714285714 3.37907904278463 0.0547588460068791 0.335818634222768 GO:0098847 sequence-specific single stranded DNA binding 3/1182 14/18639 0.214285714285714 3.37907904278463 0.0547588460068791 0.335818634222768 GO:1990825 sequence-specific mRNA binding 3/1182 14/18639 0.214285714285714 3.37907904278463 0.0547588460068791 0.335818634222768 GO:0003727 single-stranded RNA binding 10/1182 89/18639 0.112359550561798 1.77180174528033 0.0549762261153644 0.335818634222768 GO:0140297 DNA-binding transcription factor binding 40/1182 488/18639 0.0819672131147541 1.29254389614712 0.0577067884307718 0.350387326160495 GO:0016835 carbon-oxygen lyase activity 9/1182 79/18639 0.113924050632911 1.79647240249309 0.0619293529589042 0.365656808372002 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/1182 24/18639 0.166666666666667 2.62817258883249 0.0620246262721739 0.365656808372002 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/1182 24/18639 0.166666666666667 2.62817258883249 0.0620246262721739 0.365656808372002 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/1182 24/18639 0.166666666666667 2.62817258883249 0.0620246262721739 0.365656808372002 GO:0060229 lipase activator activity 4/1182 24/18639 0.166666666666667 2.62817258883249 0.0620246262721739 0.365656808372002 GO:0008009 chemokine activity 6/1182 45/18639 0.133333333333333 2.10253807106599 0.0632570661831194 0.370766850344989 GO:0051371 muscle alpha-actinin binding 3/1182 15/18639 0.2 3.15380710659898 0.0653243897693491 0.380683512793793 GO:0019208 phosphatase regulator activity 12/1182 117/18639 0.102564102564103 1.61733697774307 0.0674362306452326 0.390744787852948 GO:0000175 3'-5'-RNA exonuclease activity 5/1182 35/18639 0.142857142857143 2.25271936185642 0.0679866518102141 0.391695823497483 GO:0008408 3'-5' exonuclease activity 7/1182 58/18639 0.120689655172414 1.9031594608787 0.0729540395328107 0.417940090882882 GO:0097110 scaffold protein binding 8/1182 70/18639 0.114285714285714 1.80217548948513 0.0745917923985271 0.422631245439247 GO:0004033 aldo-keto reductase (NADPH) activity 5/1182 36/18639 0.138888888888889 2.19014382402707 0.075023298006967 0.422631245439247 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/1182 36/18639 0.138888888888889 2.19014382402707 0.075023298006967 0.422631245439247 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 13/1182 132/18639 0.0984848484848485 1.5530110752192 0.0758185383998861 0.424751369820357 GO:0017070 U6 snRNA binding 3/1182 16/18639 0.1875 2.95669416243655 0.0767436447589586 0.427571735085627 GO:0097602 cullin family protein binding 4/1182 26/18639 0.153846153846154 2.4260054666146 0.0790792067255175 0.438176588085654 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/1182 48/18639 0.125 1.97112944162437 0.0814504674171851 0.448862901962096 GO:0043394 proteoglycan binding 5/1182 37/18639 0.135135135135135 2.13095074770202 0.0824386703234049 0.451853036259095 GO:0004860 protein kinase inhibitor activity 9/1182 84/18639 0.107142857142857 1.68953952139231 0.0842054509679345 0.456600680649656 GO:0051117 ATPase binding 9/1182 84/18639 0.107142857142857 1.68953952139231 0.0842054509679345 0.456600680649656 GO:0016763 pentosyltransferase activity 6/1182 49/18639 0.122448979591837 1.93090231016264 0.088098501389731 0.467427758730681 GO:0004364 glutathione transferase activity 4/1182 27/18639 0.148148148148148 2.33615341229554 0.0883905565288319 0.467427758730681 GO:0023026 MHC class II protein complex binding 4/1182 27/18639 0.148148148148148 2.33615341229554 0.0883905565288319 0.467427758730681 GO:0016018 cyclosporin A binding 3/1182 17/18639 0.176470588235294 2.78277097641087 0.0889680053599818 0.467427758730681 GO:0031489 myosin V binding 3/1182 17/18639 0.176470588235294 2.78277097641087 0.0889680053599818 0.467427758730681 GO:0048038 quinone binding 3/1182 17/18639 0.176470588235294 2.78277097641087 0.0889680053599818 0.467427758730681 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/1182 38/18639 0.131578947368421 2.0748730964467 0.0902268128768537 0.469648585858012 GO:0043539 protein serine/threonine kinase activator activity 8/1182 73/18639 0.10958904109589 1.72811348306794 0.0903170357419253 0.469648585858012 GO:0016866 intramolecular transferase activity 4/1182 28/18639 0.142857142857143 2.25271936185642 0.0982028191298341 0.506384531646091 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/1182 39/18639 0.128205128205128 2.02167122217884 0.0983804267596449 0.506384531646091 GO:0004532 RNA exonuclease activity 5/1182 40/18639 0.125 1.97112944162437 0.10689095851466 0.541937159669327 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1182 40/18639 0.125 1.97112944162437 0.10689095851466 0.541937159669327 GO:0140662 ATP-dependent protein folding chaperone 5/1182 40/18639 0.125 1.97112944162437 0.10689095851466 0.541937159669327 GO:0003785 actin monomer binding 4/1182 29/18639 0.137931034482759 2.17503938386137 0.108496948128494 0.547342812946732 GO:0005080 protein kinase C binding 6/1182 52/18639 0.115384615384615 1.81950409996095 0.109748393434117 0.55091520268413 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1182 19/18639 0.157894736842105 2.48984771573604 0.115620045931116 0.571896227190984 GO:0031420 alkali metal ion binding 3/1182 19/18639 0.157894736842105 2.48984771573604 0.115620045931116 0.571896227190984 GO:0034987 immunoglobulin receptor binding 3/1182 19/18639 0.157894736842105 2.48984771573604 0.115620045931116 0.571896227190984 GO:0019210 kinase inhibitor activity 9/1182 90/18639 0.1 1.57690355329949 0.116510192784103 0.572898511049493 GO:0005544 calcium-dependent phospholipid binding 6/1182 53/18639 0.113207547169811 1.78517383392395 0.117517643292204 0.572898511049493 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/1182 53/18639 0.113207547169811 1.78517383392395 0.117517643292204 0.572898511049493 GO:0001968 fibronectin binding 4/1182 30/18639 0.133333333333333 2.10253807106599 0.119252064162956 0.575095468150955 GO:0042056 chemoattractant activity 5/1182 42/18639 0.119047619047619 1.87726613488035 0.12494284158919 0.575095468150955 GO:0048487 beta-tubulin binding 5/1182 42/18639 0.119047619047619 1.87726613488035 0.12494284158919 0.575095468150955 GO:0051287 NAD binding 6/1182 54/18639 0.111111111111111 1.75211505922166 0.12555339592137 0.575095468150955 GO:0031072 heat shock protein binding 12/1182 131/18639 0.0916030534351145 1.44449180454915 0.12745534404117 0.575095468150955 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0004090 carbonyl reductase (NADPH) activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0005031 tumor necrosis factor receptor activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0005381 iron ion transmembrane transporter activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0005522 profilin binding 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0008239 dipeptidyl-peptidase activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0031720 haptoglobin binding 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0031996 thioesterase binding 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0140940 histone H2A methyltransferase activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0141109 transporter activator activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:1990259 histone H2AQ104 methyltransferase activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:1990757 ubiquitin ligase activator activity 2/1182 10/18639 0.2 3.15380710659898 0.128943330161814 0.575095468150955 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 3/1182 20/18639 0.15 2.36535532994924 0.129936018672728 0.575095468150955 GO:0010851 cyclase regulator activity 3/1182 20/18639 0.15 2.36535532994924 0.129936018672728 0.575095468150955 GO:0016004 phospholipase activator activity 3/1182 20/18639 0.15 2.36535532994924 0.129936018672728 0.575095468150955 GO:0008327 methyl-CpG binding 4/1182 31/18639 0.129032258064516 2.03471426232193 0.130445717627929 0.575095468150955 GO:0048156 tau protein binding 5/1182 43/18639 0.116279069767442 1.83360878290639 0.13446164868044 0.5902342500518 GO:0019888 protein phosphatase regulator activity 10/1182 107/18639 0.0934579439252336 1.47374163859766 0.140833782787563 0.6155407575284 GO:0019205 nucleobase-containing compound kinase activity 5/1182 44/18639 0.113636363636364 1.79193585602215 0.144292475727705 0.623423202736947 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1182 21/18639 0.142857142857143 2.25271936185642 0.144835408460561 0.623423202736947 GO:0010314 phosphatidylinositol-5-phosphate binding 3/1182 21/18639 0.142857142857143 2.25271936185642 0.144835408460561 0.623423202736947 GO:0003697 single-stranded DNA binding 11/1182 121/18639 0.0909090909090909 1.43354868481772 0.145354519424206 0.623423202736947 GO:0016504 peptidase activator activity 6/1182 57/18639 0.105263157894737 1.65989847715736 0.151187753370051 0.623423202736947 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0019206 nucleoside kinase activity 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0019864 IgG binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0032050 clathrin heavy chain binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0032794 GTPase activating protein binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0034713 type I transforming growth factor beta receptor binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0050998 nitric-oxide synthase binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0070697 activin receptor binding 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1182 11/18639 0.181818181818182 2.86709736963544 0.151244682320798 0.623423202736947 GO:0002020 protease binding 12/1182 136/18639 0.0882352941176471 1.39138548820543 0.154394008110635 0.631386324788989 GO:0042605 peptide antigen binding 5/1182 45/18639 0.111111111111111 1.75211505922166 0.154421901920778 0.631386324788989 GO:0034062 5'-3' RNA polymerase activity 3/1182 22/18639 0.136363636363636 2.15032302722658 0.160260321613963 0.650015864466235 GO:0097747 RNA polymerase activity 3/1182 22/18639 0.136363636363636 2.15032302722658 0.160260321613963 0.650015864466235 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1182 34/18639 0.117647058823529 1.85518065094058 0.166415047181937 0.664012410351585 GO:0030332 cyclin binding 4/1182 34/18639 0.117647058823529 1.85518065094058 0.166415047181937 0.664012410351585 GO:0003712 transcription coregulator activity 37/1182 495/18639 0.0747474747474747 1.17869558529457 0.168996791233836 0.664012410351585 GO:0001786 phosphatidylserine binding 6/1182 59/18639 0.101694915254237 1.60363073216898 0.169468068920841 0.664012410351585 GO:0015459 potassium channel regulator activity 6/1182 59/18639 0.101694915254237 1.60363073216898 0.169468068920841 0.664012410351585 GO:0004032 aldose reductase (NADPH) activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0004126 cytidine deaminase activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0008179 adenylate cyclase binding 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0016208 AMP binding 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0031543 peptidyl-proline dioxygenase activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0036009 protein-glutamine N-methyltransferase activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0070008 serine-type exopeptidase activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1182 12/18639 0.166666666666667 2.62817258883249 0.174222210327934 0.664012410351585 GO:0005504 fatty acid binding 5/1182 47/18639 0.106382978723404 1.6775569715952 0.175519512696407 0.664012410351585 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1182 23/18639 0.130434782608696 2.05683072169499 0.176153193673152 0.664012410351585 GO:0017134 fibroblast growth factor binding 3/1182 23/18639 0.130434782608696 2.05683072169499 0.176153193673152 0.664012410351585 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1182 23/18639 0.130434782608696 2.05683072169499 0.176153193673152 0.664012410351585 GO:0071617 lysophospholipid acyltransferase activity 3/1182 23/18639 0.130434782608696 2.05683072169499 0.176153193673152 0.664012410351585 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/1182 60/18639 0.1 1.57690355329949 0.178938299188136 0.672012723617665 GO:0005484 SNAP receptor activity 4/1182 36/18639 0.111111111111111 1.75211505922166 0.192127008705349 0.70836920646201 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1182 36/18639 0.111111111111111 1.75211505922166 0.192127008705349 0.70836920646201 GO:0005540 hyaluronic acid binding 3/1182 24/18639 0.125 1.97112944162437 0.192457274730435 0.70836920646201 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/1182 24/18639 0.125 1.97112944162437 0.192457274730435 0.70836920646201 GO:0017124 SH3 domain binding 10/1182 115/18639 0.0869565217391304 1.37122048112999 0.193546850668165 0.70836920646201 GO:0060590 ATPase regulator activity 5/1182 49/18639 0.102040816326531 1.60908525846887 0.197634963819211 0.70836920646201 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0005035 death receptor activity 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0005542 folic acid binding 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0035325 Toll-like receptor binding 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0140666 annealing activity 2/1182 13/18639 0.153846153846154 2.4260054666146 0.197700675965236 0.70836920646201 GO:0051020 GTPase binding 24/1182 315/18639 0.0761904761904762 1.20145032632342 0.202422874122384 0.722735191408795 GO:0023023 MHC protein complex binding 4/1182 37/18639 0.108108108108108 1.70476059816161 0.205422564872858 0.726748403975274 GO:0042805 actinin binding 4/1182 37/18639 0.108108108108108 1.70476059816161 0.205422564872858 0.726748403975274 GO:0016741 transferase activity, transferring one-carbon groups 17/1182 215/18639 0.0790697674418605 1.24685397237634 0.205697033472292 0.726748403975274 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/1182 25/18639 0.12 1.89228426395939 0.209117033418577 0.732189549463866 GO:0017056 structural constituent of nuclear pore 3/1182 25/18639 0.12 1.89228426395939 0.209117033418577 0.732189549463866 GO:0005085 guanyl-nucleotide exchange factor activity 18/1182 230/18639 0.0782608695652174 1.23409843301699 0.209403322824971 0.732189549463866 GO:0072341 modified amino acid binding 8/1182 91/18639 0.0879120879120879 1.38628883806549 0.219252949332807 0.763994813139058 GO:0005344 oxygen carrier activity 2/1182 14/18639 0.142857142857143 2.25271936185642 0.221524314291629 0.764032839087454 GO:0008191 metalloendopeptidase inhibitor activity 2/1182 14/18639 0.142857142857143 2.25271936185642 0.221524314291629 0.764032839087454 GO:0019763 immunoglobulin receptor activity 2/1182 14/18639 0.142857142857143 2.25271936185642 0.221524314291629 0.764032839087454 GO:0015216 purine nucleotide transmembrane transporter activity 3/1182 26/18639 0.115384615384615 1.81950409996095 0.226078489074193 0.777096908207566 GO:0019209 kinase activator activity 12/1182 148/18639 0.0810810810810811 1.27857044862121 0.229544652611454 0.786266761519957 GO:0032182 ubiquitin-like protein binding 10/1182 120/18639 0.0833333333333333 1.31408629441624 0.230297069202591 0.786266761519957 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/1182 52/18639 0.0961538461538462 1.51625341663413 0.232439172628902 0.790917184717137 GO:0051219 phosphoprotein binding 8/1182 93/18639 0.0860215053763441 1.35647617488128 0.236639660832099 0.802517110647989 GO:0001671 ATPase activator activity 3/1182 27/18639 0.111111111111111 1.75211505922166 0.243289480642363 0.806257068289087 GO:0008266 poly(U) RNA binding 3/1182 27/18639 0.111111111111111 1.75211505922166 0.243289480642363 0.806257068289087 GO:0140296 general transcription initiation factor binding 5/1182 53/18639 0.0943396226415094 1.48764486160329 0.244410165268142 0.806257068289087 GO:0016779 nucleotidyltransferase activity 11/1182 136/18639 0.0808823529411765 1.27543669752165 0.244725553575255 0.806257068289087 GO:0000774 adenyl-nucleotide exchange factor activity 2/1182 15/18639 0.133333333333333 2.10253807106599 0.245555071910441 0.806257068289087 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1182 15/18639 0.133333333333333 2.10253807106599 0.245555071910441 0.806257068289087 GO:0016846 carbon-sulfur lyase activity 2/1182 15/18639 0.133333333333333 2.10253807106599 0.245555071910441 0.806257068289087 GO:0017081 chloride channel regulator activity 2/1182 15/18639 0.133333333333333 2.10253807106599 0.245555071910441 0.806257068289087 GO:0042809 nuclear vitamin D receptor binding 2/1182 15/18639 0.133333333333333 2.10253807106599 0.245555071910441 0.806257068289087 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 10/1182 122/18639 0.0819672131147541 1.29254389614712 0.24569372199342 0.806257068289087 GO:0015631 tubulin binding 28/1182 385/18639 0.0727272727272727 1.14683894785418 0.251769184253655 0.815134287803973 GO:0016922 nuclear receptor binding 11/1182 137/18639 0.0802919708029197 1.26612694060543 0.252112553798265 0.815134287803973 GO:0015485 cholesterol binding 5/1182 54/18639 0.0925925925925926 1.46009588268472 0.25653840703822 0.815134287803973 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/1182 54/18639 0.0925925925925926 1.46009588268472 0.25653840703822 0.815134287803973 GO:0046906 tetrapyrrole binding 12/1182 152/18639 0.0789473684210526 1.24492385786802 0.257391954055011 0.815134287803973 GO:0019789 SUMO transferase activity 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0046625 sphingolipid binding 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0046875 ephrin receptor binding 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0046966 nuclear thyroid hormone receptor binding 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0051393 alpha-actinin binding 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/1182 28/18639 0.107142857142857 1.68953952139231 0.260699880023867 0.815134287803973 GO:0001530 lipopolysaccharide binding 4/1182 41/18639 0.0975609756097561 1.53844249102389 0.260903867300388 0.815134287803973 GO:0004812 aminoacyl-tRNA ligase activity 4/1182 41/18639 0.0975609756097561 1.53844249102389 0.260903867300388 0.815134287803973 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1182 41/18639 0.0975609756097561 1.53844249102389 0.260903867300388 0.815134287803973 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/1182 41/18639 0.0975609756097561 1.53844249102389 0.260903867300388 0.815134287803973 GO:0140223 general transcription initiation factor activity 6/1182 68/18639 0.0882352941176471 1.39138548820543 0.261260989680761 0.815134287803973 GO:0030295 protein kinase activator activity 11/1182 139/18639 0.079136690647482 1.24790928678377 0.267114976290133 0.826122005848905 GO:0005159 insulin-like growth factor receptor binding 2/1182 16/18639 0.125 1.97112944162437 0.269670990074939 0.826122005848905 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1182 16/18639 0.125 1.97112944162437 0.269670990074939 0.826122005848905 GO:0008296 3'-5'-DNA exonuclease activity 2/1182 16/18639 0.125 1.97112944162437 0.269670990074939 0.826122005848905 GO:0016722 oxidoreductase activity, acting on metal ions 2/1182 16/18639 0.125 1.97112944162437 0.269670990074939 0.826122005848905 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1182 16/18639 0.125 1.97112944162437 0.269670990074939 0.826122005848905 GO:0043175 RNA polymerase core enzyme binding 4/1182 42/18639 0.0952380952380952 1.50181290790428 0.275215554217356 0.838043759688887 GO:0051879 Hsp90 protein binding 4/1182 42/18639 0.0952380952380952 1.50181290790428 0.275215554217356 0.838043759688887 GO:0043236 laminin binding 3/1182 29/18639 0.103448275862069 1.63127953789603 0.278261756781025 0.844782698730418 GO:0019212 phosphatase inhibitor activity 5/1182 56/18639 0.0892857142857143 1.40794960116026 0.281200620205772 0.848623300263848 GO:0030170 pyridoxal phosphate binding 5/1182 56/18639 0.0892857142857143 1.40794960116026 0.281200620205772 0.848623300263848 GO:0004527 exonuclease activity 7/1182 84/18639 0.0833333333333333 1.31408629441624 0.283226549734724 0.852200953801219 GO:0020037 heme binding 11/1182 142/18639 0.0774647887323944 1.22154500607707 0.290136083114011 0.852478731281048 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25/1182 349/18639 0.0716332378223496 1.12958707256411 0.292035685705272 0.852478731281048 GO:0070279 vitamin B6 binding 5/1182 57/18639 0.087719298245614 1.38324873096447 0.293701857401514 0.852478731281048 GO:0004659 prenyltransferase activity 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0005092 GDP-dissociation inhibitor activity 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0032977 membrane insertase activity 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0036041 long-chain fatty acid binding 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0045236 CXCR chemokine receptor binding 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0070402 NADPH binding 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0070403 NAD+ binding 2/1182 17/18639 0.117647058823529 1.85518065094058 0.293764721370266 0.852478731281048 GO:0005126 cytokine receptor binding 20/1182 275/18639 0.0727272727272727 1.14683894785418 0.294769456714974 0.852478731281048 GO:0001965 G-protein alpha-subunit binding 3/1182 30/18639 0.1 1.57690355329949 0.295929500405255 0.852478731281048 GO:0008187 poly-pyrimidine tract binding 3/1182 30/18639 0.1 1.57690355329949 0.295929500405255 0.852478731281048 GO:0015215 nucleotide transmembrane transporter activity 3/1182 30/18639 0.1 1.57690355329949 0.295929500405255 0.852478731281048 GO:0031210 phosphatidylcholine binding 3/1182 30/18639 0.1 1.57690355329949 0.295929500405255 0.852478731281048 GO:0043130 ubiquitin binding 8/1182 100/18639 0.08 1.26152284263959 0.300722627826728 0.863832137723237 GO:0050660 flavin adenine dinucleotide binding 7/1182 86/18639 0.0813953488372093 1.28352614803447 0.30357600180399 0.868534263678813 GO:0001046 core promoter sequence-specific DNA binding 4/1182 44/18639 0.0909090909090909 1.43354868481772 0.304187789870486 0.868534263678813 GO:0042379 chemokine receptor binding 6/1182 72/18639 0.0833333333333333 1.31408629441624 0.305644150567336 0.868534263678813 GO:0019903 protein phosphatase binding 11/1182 144/18639 0.0763888888888889 1.20457910321489 0.305785731886919 0.868534263678813 GO:0005125 cytokine activity 17/1182 234/18639 0.0726495726495727 1.14561369256801 0.316063235216578 0.878884892096188 GO:0046982 protein heterodimerization activity 26/1182 369/18639 0.0704607046070461 1.11109735462837 0.316737924521362 0.878884892096188 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1182 18/18639 0.111111111111111 1.75211505922166 0.317742169554211 0.878884892096188 GO:0008308 voltage-gated monoatomic anion channel activity 2/1182 18/18639 0.111111111111111 1.75211505922166 0.317742169554211 0.878884892096188 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1182 18/18639 0.111111111111111 1.75211505922166 0.317742169554211 0.878884892096188 GO:0035615 clathrin adaptor activity 2/1182 18/18639 0.111111111111111 1.75211505922166 0.317742169554211 0.878884892096188 GO:1990381 ubiquitin-specific protease binding 2/1182 18/18639 0.111111111111111 1.75211505922166 0.317742169554211 0.878884892096188 GO:0046915 transition metal ion transmembrane transporter activity 4/1182 45/18639 0.0888888888888889 1.40169204737733 0.318799096011922 0.878884892096188 GO:0051539 4 iron, 4 sulfur cluster binding 4/1182 45/18639 0.0888888888888889 1.40169204737733 0.318799096011922 0.878884892096188 GO:0045309 protein phosphorylated amino acid binding 5/1182 59/18639 0.0847457627118644 1.33635894347415 0.318964142299208 0.878884892096188 GO:0070063 RNA polymerase binding 5/1182 59/18639 0.0847457627118644 1.33635894347415 0.318964142299208 0.878884892096188 GO:0004722 protein serine/threonine phosphatase activity 8/1182 103/18639 0.0776699029126214 1.22477945887339 0.329332029551464 0.904133002961876 GO:0140142 nucleocytoplasmic carrier activity 3/1182 32/18639 0.09375 1.47834708121827 0.331412226269198 0.904133002961876 GO:0008083 growth factor activity 12/1182 162/18639 0.0740740740740741 1.16807670614777 0.331418398439378 0.904133002961876 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/1182 60/18639 0.0833333333333333 1.31408629441624 0.331693764400215 0.904133002961876 GO:0015245 fatty acid transmembrane transporter activity 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0030506 ankyrin binding 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0043395 heparan sulfate proteoglycan binding 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0050145 nucleoside monophosphate kinase activity 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0097001 ceramide binding 2/1182 19/18639 0.105263157894737 1.65989847715736 0.341521242921634 0.916144286567557 GO:0016836 hydro-lyase activity 5/1182 61/18639 0.0819672131147541 1.29254389614712 0.344468607183641 0.921612579641719 GO:0004518 nuclease activity 15/1182 209/18639 0.0717703349282297 1.1317489616982 0.347903384989573 0.921969466922638 GO:0043495 protein-membrane adaptor activity 4/1182 47/18639 0.0851063829787234 1.34204557727616 0.348154614547328 0.921969466922638 GO:0019239 deaminase activity 3/1182 33/18639 0.0909090909090909 1.43354868481772 0.349148200491413 0.921969466922638 GO:0019956 chemokine binding 3/1182 33/18639 0.0909090909090909 1.43354868481772 0.349148200491413 0.921969466922638 GO:0071889 14-3-3 protein binding 3/1182 33/18639 0.0909090909090909 1.43354868481772 0.349148200491413 0.921969466922638 GO:0019842 vitamin binding 11/1182 150/18639 0.0733333333333333 1.15639593908629 0.353854728397815 0.931970635312688 GO:0004540 RNA nuclease activity 9/1182 121/18639 0.0743801652892562 1.17290346939632 0.360205779133871 0.946240051921621 GO:0032266 phosphatidylinositol-3-phosphate binding 4/1182 48/18639 0.0833333333333333 1.31408629441624 0.362854327344778 0.946652537735498 GO:0016408 C-acyltransferase activity 2/1182 20/18639 0.1 1.57690355329949 0.365030712282623 0.946652537735498 GO:0031418 L-ascorbic acid binding 2/1182 20/18639 0.1 1.57690355329949 0.365030712282623 0.946652537735498 GO:0042288 MHC class I protein binding 2/1182 20/18639 0.1 1.57690355329949 0.365030712282623 0.946652537735498 GO:0061608 nuclear import signal receptor activity 2/1182 20/18639 0.1 1.57690355329949 0.365030712282623 0.946652537735498 GO:0043178 alcohol binding 7/1182 92/18639 0.0760869565217391 1.19981792098874 0.366051548642499 0.946878240621157 GO:0051213 dioxygenase activity 7/1182 93/18639 0.0752688172043011 1.18691665302112 0.376585074394508 0.971209916147191 GO:0001222 transcription corepressor binding 4/1182 49/18639 0.0816326530612245 1.2872682067751 0.377540492991494 0.971209916147191 GO:0003774 cytoskeletal motor activity 11/1182 153/18639 0.0718954248366013 1.13372150890813 0.378331278972525 0.971209916147191 GO:0004536 DNA nuclease activity 5/1182 64/18639 0.078125 1.23195590101523 0.382917654171633 0.974366568393455 GO:0034061 DNA polymerase activity 3/1182 35/18639 0.0857142857142857 1.35163161711385 0.384430482357155 0.974366568393455 GO:0033293 monocarboxylic acid binding 6/1182 79/18639 0.0759493670886076 1.19764826832873 0.385735930357061 0.974366568393455 GO:0140101 catalytic activity, acting on a tRNA 10/1182 139/18639 0.0719424460431655 1.13446298798525 0.387212308502166 0.974366568393455 GO:0140767 enzyme-substrate adaptor activity 10/1182 139/18639 0.0719424460431655 1.13446298798525 0.387212308502166 0.974366568393455 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1182 21/18639 0.0952380952380952 1.50181290790428 0.388209165316524 0.974366568393455 GO:0051428 peptide hormone receptor binding 2/1182 21/18639 0.0952380952380952 1.50181290790428 0.388209165316524 0.974366568393455 GO:0140312 cargo adaptor activity 2/1182 21/18639 0.0952380952380952 1.50181290790428 0.388209165316524 0.974366568393455 GO:1904047 S-adenosyl-L-methionine binding 2/1182 21/18639 0.0952380952380952 1.50181290790428 0.388209165316524 0.974366568393455 GO:0015605 organophosphate ester transmembrane transporter activity 4/1182 50/18639 0.08 1.26152284263959 0.392193135010101 0.981935404691956 GO:0003730 mRNA 3'-UTR binding 18/1182 262/18639 0.0687022900763359 1.08336885341187 0.397365286220424 0.988360591671888 GO:0004867 serine-type endopeptidase inhibitor activity 7/1182 95/18639 0.0736842105263158 1.16192893401015 0.397683551678629 0.988360591671888 GO:0008276 protein methyltransferase activity 7/1182 95/18639 0.0736842105263158 1.16192893401015 0.397683551678629 0.988360591671888 GO:0000993 RNA polymerase II complex binding 3/1182 36/18639 0.0833333333333333 1.31408629441624 0.401912616325501 0.993998519400141 GO:0045505 dynein intermediate chain binding 3/1182 36/18639 0.0833333333333333 1.31408629441624 0.401912616325501 0.993998519400141 GO:0019787 ubiquitin-like protein transferase activity 32/1182 479/18639 0.0668058455114822 1.05346375168233 0.405765404523987 0.999999996065309 GO:0016830 carbon-carbon lyase activity 4/1182 51/18639 0.0784313725490196 1.23678710062705 0.40679323311124 0.999999996065309 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1182 22/18639 0.0909090909090909 1.43354868481772 0.41100404968678 0.999999996065309 GO:0140784 metal ion sensor activity 2/1182 22/18639 0.0909090909090909 1.43354868481772 0.41100404968678 0.999999996065309 GO:0016755 aminoacyltransferase activity 33/1182 496/18639 0.0665322580645161 1.04914954150974 0.412929016249561 0.999999996065309 GO:0008168 methyltransferase activity 14/1182 204/18639 0.0686274509803922 1.08218871304867 0.419650171891745 0.999999996065309 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/1182 67/18639 0.0746268656716418 1.17679369649216 0.421263056576562 0.999999996065309 GO:0019902 phosphatase binding 13/1182 190/18639 0.068421052631579 1.07893401015228 0.429766445931016 0.999999996065309 GO:0003887 DNA-directed DNA polymerase activity 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0005212 structural constituent of eye lens 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0031681 G-protein beta-subunit binding 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0043274 phospholipase binding 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0099186 structural constituent of postsynapse 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0140102 catalytic activity, acting on a rRNA 2/1182 23/18639 0.0869565217391304 1.37122048112999 0.433370797878554 0.999999996065309 GO:0030145 manganese ion binding 5/1182 68/18639 0.0735294117647059 1.15948790683786 0.433961633314323 0.999999996065309 GO:0032934 sterol binding 5/1182 68/18639 0.0735294117647059 1.15948790683786 0.433961633314323 0.999999996065309 GO:0004864 protein phosphatase inhibitor activity 4/1182 53/18639 0.0754716981132075 1.19011588928264 0.435764580835786 0.999999996065309 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1182 53/18639 0.0754716981132075 1.19011588928264 0.435764580835786 0.999999996065309 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1182 130/18639 0.0692307692307692 1.09170245997657 0.442642895046001 0.999999996065309 GO:0001221 transcription coregulator binding 8/1182 115/18639 0.0695652173913043 1.09697638490399 0.446324281222735 0.999999996065309 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/1182 39/18639 0.0769230769230769 1.2130027333073 0.453387995898437 0.999999996065309 GO:0005315 phosphate transmembrane transporter activity 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0015149 hexose transmembrane transporter activity 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0015295 solute:proton symporter activity 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0035035 histone acetyltransferase binding 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0055056 D-glucose transmembrane transporter activity 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0070840 dynein complex binding 2/1182 24/18639 0.0833333333333333 1.31408629441624 0.455272027255656 0.999999996065309 GO:0005179 hormone activity 9/1182 132/18639 0.0681818181818182 1.07516151361329 0.460889139122276 0.999999996065309 GO:0008374 O-acyltransferase activity 4/1182 55/18639 0.0727272727272727 1.14683894785418 0.464321914197419 0.999999996065309 GO:0004177 aminopeptidase activity 3/1182 40/18639 0.075 1.18267766497462 0.470143045287262 0.999999996065309 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/1182 40/18639 0.075 1.18267766497462 0.470143045287262 0.999999996065309 GO:0030331 nuclear estrogen receptor binding 3/1182 40/18639 0.075 1.18267766497462 0.470143045287262 0.999999996065309 GO:0050997 quaternary ammonium group binding 3/1182 40/18639 0.075 1.18267766497462 0.470143045287262 0.999999996065309 GO:0000030 mannosyltransferase activity 2/1182 25/18639 0.08 1.26152284263959 0.476676809328445 0.999999996065309 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1182 25/18639 0.08 1.26152284263959 0.476676809328445 0.999999996065309 GO:0017025 TBP-class protein binding 2/1182 25/18639 0.08 1.26152284263959 0.476676809328445 0.999999996065309 GO:0042974 nuclear retinoic acid receptor binding 2/1182 25/18639 0.08 1.26152284263959 0.476676809328445 0.999999996065309 GO:0047617 fatty acyl-CoA hydrolase activity 2/1182 25/18639 0.08 1.26152284263959 0.476676809328445 0.999999996065309 GO:0000182 rDNA binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0003796 lysozyme activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0004955 prostaglandin receptor activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0005345 purine nucleobase transmembrane transporter activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0008140 cAMP response element binding protein binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0008190 eukaryotic initiation factor 4E binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0016783 sulfurtransferase activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0031419 cobalamin binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0031434 mitogen-activated protein kinase kinase binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0032052 bile acid binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0032356 oxidized DNA binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0032395 MHC class II receptor activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0033204 ribonuclease P RNA binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0035256 G protein-coupled glutamate receptor binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0042975 peroxisome proliferator activated receptor binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0043208 glycosphingolipid binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0050308 sugar-phosphatase activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0051880 G-quadruplex DNA binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0070513 death domain binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0099122 RNA polymerase II C-terminal domain binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:1905394 retromer complex binding 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1182 10/18639 0.1 1.57690355329949 0.480723084073505 0.999999996065309 GO:0140098 catalytic activity, acting on RNA 25/1182 387/18639 0.0645994832041344 1.0186715460591 0.491720099494942 0.999999996065309 GO:0019838 growth factor binding 9/1182 136/18639 0.0661764705882353 1.04353911615408 0.49702460561025 0.999999996065309 GO:0004529 DNA exonuclease activity 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0005160 transforming growth factor beta receptor binding 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0015145 monosaccharide transmembrane transporter activity 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0016289 acyl-CoA hydrolase activity 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0019865 immunoglobulin binding 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0030507 spectrin binding 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0043548 phosphatidylinositol 3-kinase binding 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0051139 metal cation:proton antiporter activity 2/1182 26/18639 0.0769230769230769 1.2130027333073 0.497560002682967 0.999999996065309 GO:0033218 amide binding 16/1182 247/18639 0.0647773279352227 1.02147598594299 0.502177162392118 0.999999996065309 GO:0019894 kinesin binding 3/1182 42/18639 0.0714285714285714 1.12635968092821 0.502927033417029 0.999999996065309 GO:0031492 nucleosomal DNA binding 3/1182 42/18639 0.0714285714285714 1.12635968092821 0.502927033417029 0.999999996065309 GO:0035198 miRNA binding 3/1182 42/18639 0.0714285714285714 1.12635968092821 0.502927033417029 0.999999996065309 GO:0017116 single-stranded DNA helicase activity 4/1182 58/18639 0.0689655172413793 1.08751969193068 0.506129991123971 0.999999996065309 GO:0003678 DNA helicase activity 5/1182 74/18639 0.0675675675675676 1.06547537385101 0.50849156250884 0.999999996065309 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0004954 prostanoid receptor activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0005114 type II transforming growth factor beta receptor binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0008432 JUN kinase binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0008503 benzodiazepine receptor activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0015205 nucleobase transmembrane transporter activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0019203 carbohydrate phosphatase activity 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0019215 intermediate filament binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0032404 mismatch repair complex binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0045294 alpha-catenin binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0048185 activin binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0140031 phosphorylation-dependent protein binding 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1182 11/18639 0.0909090909090909 1.43354868481772 0.513670924248776 0.999999996065309 GO:0140104 molecular carrier activity 16/1182 249/18639 0.0642570281124498 1.01327135954987 0.515449028214782 0.999999996065309 GO:0008320 protein transmembrane transporter activity 2/1182 27/18639 0.0740740740740741 1.16807670614777 0.517901644446215 0.999999996065309 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1182 27/18639 0.0740740740740741 1.16807670614777 0.517901644446215 0.999999996065309 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1182 43/18639 0.0697674418604651 1.10016526974383 0.51892267200672 0.999999996065309 GO:0030695 GTPase regulator activity 31/1182 489/18639 0.0633946830265849 0.999673009249167 0.527920194815783 0.999999996065309 GO:0031267 small GTPase binding 18/1182 283/18639 0.0636042402826855 1.00297752506681 0.529923372507639 0.999999996065309 GO:0060589 nucleoside-triphosphatase regulator activity 31/1182 490/18639 0.063265306122449 0.997632860250699 0.532653274577889 0.999999996065309 GO:0016790 thiolester hydrolase activity 3/1182 44/18639 0.0681818181818182 1.07516151361329 0.534634980455713 0.999999996065309 GO:0030547 signaling receptor inhibitor activity 3/1182 44/18639 0.0681818181818182 1.07516151361329 0.534634980455713 0.999999996065309 GO:0051119 sugar transmembrane transporter activity 2/1182 28/18639 0.0714285714285714 1.12635968092821 0.537686395555626 0.999999996065309 GO:0097718 disordered domain specific binding 2/1182 28/18639 0.0714285714285714 1.12635968092821 0.537686395555626 0.999999996065309 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0003720 telomerase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0003995 acyl-CoA dehydrogenase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0004300 enoyl-CoA hydratase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0004526 ribonuclease P activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0005049 nuclear export signal receptor activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0015368 calcium:monoatomic cation antiporter activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016273 arginine N-methyltransferase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016274 protein-arginine N-methyltransferase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016423 tRNA (guanine) methyltransferase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016801 hydrolase activity, acting on ether bonds 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016803 ether hydrolase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0016840 carbon-nitrogen lyase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0035197 siRNA binding 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0035251 UDP-glucosyltransferase activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0035259 nuclear glucocorticoid receptor binding 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0042301 phosphate ion binding 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0070410 co-SMAD binding 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0097677 STAT family protein binding 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0140900 chloride:bicarbonate antiporter activity 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1182 12/18639 0.0833333333333333 1.31408629441624 0.544529898241579 0.999999996065309 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/1182 45/18639 0.0666666666666667 1.05126903553299 0.550051829344556 0.999999996065309 GO:0004721 phosphoprotein phosphatase activity 11/1182 175/18639 0.0628571428571429 0.991196519216824 0.556592899176679 0.999999996065309 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1182 29/18639 0.0689655172413793 1.08751969193068 0.556903035464855 0.999999996065309 GO:0097472 cyclin-dependent protein kinase activity 2/1182 29/18639 0.0689655172413793 1.08751969193068 0.556903035464855 0.999999996065309 GO:0042826 histone deacetylase binding 8/1182 127/18639 0.062992125984252 0.993325072944562 0.559809624680525 0.999999996065309 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/1182 46/18639 0.0652173913043478 1.02841536084749 0.565162729150899 0.999999996065309 GO:0030276 clathrin binding 3/1182 46/18639 0.0652173913043478 1.02841536084749 0.565162729150899 0.999999996065309 GO:0030291 protein serine/threonine kinase inhibitor activity 3/1182 46/18639 0.0652173913043478 1.02841536084749 0.565162729150899 0.999999996065309 GO:0003964 RNA-directed DNA polymerase activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0004465 lipoprotein lipase activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0005172 vascular endothelial growth factor receptor binding 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0008253 5'-nucleotidase activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0031994 insulin-like growth factor I binding 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0043560 insulin receptor substrate binding 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0061459 L-arginine transmembrane transporter activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0089720 caspase binding 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0140333 glycerophospholipid flippase activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1182 13/18639 0.0769230769230769 1.2130027333073 0.573432333431274 0.999999996065309 GO:0016407 acetyltransferase activity 6/1182 96/18639 0.0625 0.985564720812183 0.574423707454174 0.999999996065309 GO:0016769 transferase activity, transferring nitrogenous groups 2/1182 30/18639 0.0666666666666667 1.05126903553299 0.575544002254827 0.999999996065309 GO:0033612 receptor serine/threonine kinase binding 2/1182 30/18639 0.0666666666666667 1.05126903553299 0.575544002254827 0.999999996065309 GO:0098918 structural constituent of synapse 2/1182 30/18639 0.0666666666666667 1.05126903553299 0.575544002254827 0.999999996065309 GO:0008017 microtubule binding 17/1182 276/18639 0.0615942028985507 0.971281174133745 0.585475994877621 0.999999996065309 GO:0033192 calmodulin-dependent protein phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0140791 histone H2AXS140 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/1182 81/18639 0.0617283950617284 0.973397255123143 0.589930334002035 0.999999996065309 GO:0005164 tumor necrosis factor receptor binding 2/1182 31/18639 0.0645161290322581 1.01735713116096 0.593604974430827 0.999999996065309 GO:0016411 acylglycerol O-acyltransferase activity 2/1182 31/18639 0.0645161290322581 1.01735713116096 0.593604974430827 0.999999996065309 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1182 31/18639 0.0645161290322581 1.01735713116096 0.593604974430827 0.999999996065309 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/1182 48/18639 0.0625 0.985564720812183 0.594432364272779 0.999999996065309 GO:0005161 platelet-derived growth factor receptor binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0008392 arachidonate epoxygenase activity 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0030983 mismatched DNA binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0031404 chloride ion binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0042043 neurexin family protein binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0061665 SUMO ligase activity 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0061783 peptidoglycan muralytic activity 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0070742 C2H2 zinc finger domain binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0071933 Arp2/3 complex binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:1901612 cardiolipin binding 1/1182 14/18639 0.0714285714285714 1.12635968092821 0.600502181057401 0.999999996065309 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/1182 82/18639 0.0609756097560976 0.961526556889934 0.600948113217135 0.999999996065309 GO:0033549 MAP kinase phosphatase activity 5/1182 82/18639 0.0609756097560976 0.961526556889934 0.600948113217135 0.999999996065309 GO:0035254 glutamate receptor binding 3/1182 49/18639 0.0612244897959184 0.965451155081322 0.608577486312863 0.999999996065309 GO:0015106 bicarbonate transmembrane transporter activity 2/1182 32/18639 0.0625 0.985564720812183 0.611084490974935 0.999999996065309 GO:0022884 macromolecule transmembrane transporter activity 2/1182 32/18639 0.0625 0.985564720812183 0.611084490974935 0.999999996065309 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1182 32/18639 0.0625 0.985564720812183 0.611084490974935 0.999999996065309 GO:0043425 bHLH transcription factor binding 2/1182 32/18639 0.0625 0.985564720812183 0.611084490974935 0.999999996065309 GO:0070717 poly-purine tract binding 2/1182 32/18639 0.0625 0.985564720812183 0.611084490974935 0.999999996065309 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/1182 83/18639 0.0602409638554217 0.949941899578007 0.611796254167604 0.999999996065309 GO:0042277 peptide binding 15/1182 249/18639 0.0602409638554217 0.949941899578007 0.61950641982682 0.999999996065309 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/1182 167/18639 0.0598802395209581 0.944253624730235 0.620347486829371 0.999999996065309 GO:0048020 CCR chemokine receptor binding 3/1182 50/18639 0.06 0.946142131979695 0.622389253417295 0.999999996065309 GO:0017018 myosin phosphatase activity 5/1182 84/18639 0.0595238095238095 0.938633067440174 0.622470734461937 0.999999996065309 GO:0004953 icosanoid receptor activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0005523 tropomyosin binding 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0008252 nucleotidase activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0015116 sulfate transmembrane transporter activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0031005 filamin binding 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0033130 acetylcholine receptor binding 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0050700 CARD domain binding 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0140161 monocarboxylate:sodium symporter activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0141050 histone H3K deacetylase activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0141051 histone H4K deacetylase activity 1/1182 15/18639 0.0666666666666667 1.05126903553299 0.625855545996469 0.999999996065309 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1182 33/18639 0.0606060606060606 0.955699123211814 0.627983606490001 0.999999996065309 GO:0030296 protein tyrosine kinase activator activity 2/1182 33/18639 0.0606060606060606 0.955699123211814 0.627983606490001 0.999999996065309 GO:0005048 signal sequence binding 3/1182 51/18639 0.0588235294117647 0.92759032547029 0.635864004686423 0.999999996065309 GO:0004842 ubiquitin-protein transferase activity 27/1182 449/18639 0.0601336302895323 0.948249352763615 0.641834588217651 0.999999996065309 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/1182 86/18639 0.0581395348837209 0.916804391453193 0.643284792500498 0.999999996065309 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1182 34/18639 0.0588235294117647 0.92759032547029 0.644305578518283 0.999999996065309 GO:0019825 oxygen binding 2/1182 34/18639 0.0588235294117647 0.92759032547029 0.644305578518283 0.999999996065309 GO:0090482 vitamin transmembrane transporter activity 2/1182 34/18639 0.0588235294117647 0.92759032547029 0.644305578518283 0.999999996065309 GO:0008080 N-acetyltransferase activity 4/1182 69/18639 0.0579710144927536 0.914146987419996 0.644666201424614 0.999999996065309 GO:0031406 carboxylic acid binding 11/1182 187/18639 0.0588235294117647 0.92759032547029 0.645351245602537 0.999999996065309 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0005149 interleukin-1 receptor binding 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0005521 lamin binding 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0008391 arachidonate monooxygenase activity 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0015378 sodium:chloride symporter activity 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0019841 retinol binding 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0070411 I-SMAD binding 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0140327 flippase activity 1/1182 16/18639 0.0625 0.985564720812183 0.649601183057905 0.999999996065309 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1182 70/18639 0.0571428571428571 0.901087744742567 0.655908802005057 0.999999996065309 GO:0043177 organic acid binding 11/1182 189/18639 0.0582010582010582 0.917774554830392 0.659181535726523 0.999999996065309 GO:0005154 epidermal growth factor receptor binding 2/1182 35/18639 0.0571428571428571 0.901087744742567 0.66005558434623 0.999999996065309 GO:0016229 steroid dehydrogenase activity 2/1182 35/18639 0.0571428571428571 0.901087744742567 0.66005558434623 0.999999996065309 GO:0034212 protein N-acetyltransferase activity 3/1182 53/18639 0.0566037735849057 0.892586916961977 0.661793260476263 0.999999996065309 GO:0070851 growth factor receptor binding 8/1182 139/18639 0.0575539568345324 0.907570390388197 0.662061288891406 0.999999996065309 GO:0016791 phosphatase activity 16/1182 273/18639 0.0586080586080586 0.924192558710325 0.66445056543204 0.999999996065309 GO:0140299 molecular sensor activity 4/1182 71/18639 0.0563380281690141 0.888396368056052 0.666909647314253 0.999999996065309 GO:0000149 SNARE binding 6/1182 106/18639 0.0566037735849057 0.892586916961977 0.670854381305459 0.999999996065309 GO:0008013 beta-catenin binding 6/1182 106/18639 0.0566037735849057 0.892586916961977 0.670854381305459 0.999999996065309 GO:0004549 tRNA-specific ribonuclease activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0004550 nucleoside diphosphate kinase activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0008429 phosphatidylethanolamine binding 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0015278 intracellularly gated calcium channel activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0019198 transmembrane receptor protein phosphatase activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0030548 acetylcholine receptor regulator activity 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0032183 SUMO binding 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0046965 nuclear retinoid X receptor binding 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:1990226 histone methyltransferase binding 1/1182 17/18639 0.0588235294117647 0.92759032547029 0.671840961913382 0.999999996065309 GO:0050661 NADP binding 3/1182 54/18639 0.0555555555555556 0.876057529610829 0.674245647872538 0.999999996065309 GO:0140463 chromatin-protein adaptor activity 3/1182 54/18639 0.0555555555555556 0.876057529610829 0.674245647872538 0.999999996065309 GO:0022829 wide pore channel activity 2/1182 37/18639 0.0540540540540541 0.852380299080807 0.689868492875833 0.999999996065309 GO:0004706 JUN kinase kinase kinase activity 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0015172 acidic amino acid transmembrane transporter activity 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0015373 monoatomic anion:sodium symporter activity 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0017128 phospholipid scramblase activity 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0031690 adrenergic receptor binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0034185 apolipoprotein binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0050811 GABA receptor binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0070064 proline-rich region binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0070628 proteasome binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0099602 neurotransmitter receptor regulator activity 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:1901611 phosphatidylglycerol binding 1/1182 18/18639 0.0555555555555556 0.876057529610829 0.692670302640393 0.999999996065309 GO:0170055 lipid transmembrane transporter activity 3/1182 56/18639 0.0535714285714286 0.844769760696157 0.698127300333655 0.999999996065309 GO:0019955 cytokine binding 8/1182 144/18639 0.0555555555555556 0.876057529610829 0.700207629084155 0.999999996065309 GO:0052689 carboxylic ester hydrolase activity 5/1182 92/18639 0.0543478260869565 0.857012800706246 0.701269496195206 0.999999996065309 GO:0004519 endonuclease activity 7/1182 127/18639 0.0551181102362205 0.869159438826492 0.702112549617505 0.999999996065309 GO:0000146 microfilament motor activity 2/1182 38/18639 0.0526315789473684 0.82994923857868 0.70394916472481 0.999999996065309 GO:0005501 retinoid binding 2/1182 38/18639 0.0526315789473684 0.82994923857868 0.70394916472481 0.999999996065309 GO:0019840 isoprenoid binding 2/1182 38/18639 0.0526315789473684 0.82994923857868 0.70394916472481 0.999999996065309 GO:0043531 ADP binding 2/1182 38/18639 0.0526315789473684 0.82994923857868 0.70394916472481 0.999999996065309 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1182 57/18639 0.0526315789473684 0.82994923857868 0.709559468882031 0.999999996065309 GO:0031490 chromatin DNA binding 7/1182 128/18639 0.0546875 0.86236913071066 0.709822420484125 0.999999996065309 GO:0003756 protein disulfide isomerase activity 1/1182 19/18639 0.0526315789473684 0.82994923857868 0.712178583735879 0.999999996065309 GO:0005520 insulin-like growth factor binding 1/1182 19/18639 0.0526315789473684 0.82994923857868 0.712178583735879 0.999999996065309 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1182 19/18639 0.0526315789473684 0.82994923857868 0.712178583735879 0.999999996065309 GO:0016918 retinal binding 1/1182 19/18639 0.0526315789473684 0.82994923857868 0.712178583735879 0.999999996065309 GO:0046527 glucosyltransferase activity 1/1182 19/18639 0.0526315789473684 0.82994923857868 0.712178583735879 0.999999996065309 GO:1902936 phosphatidylinositol bisphosphate binding 6/1182 111/18639 0.0540540540540541 0.852380299080807 0.713467105523616 0.999999996065309 GO:0016410 N-acyltransferase activity 5/1182 94/18639 0.0531914893617021 0.838778485797602 0.719072694480219 0.999999996065309 GO:0061980 regulatory RNA binding 3/1182 58/18639 0.0517241379310345 0.815639768948013 0.720655622214289 0.999999996065309 GO:0016798 hydrolase activity, acting on glycosyl bonds 7/1182 130/18639 0.0538461538461538 0.849101913315111 0.724838783929122 0.999999996065309 GO:0001972 retinoic acid binding 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0030627 pre-mRNA 5'-splice site binding 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0030742 GTP-dependent protein binding 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0052745 inositol phosphate phosphatase activity 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0140664 ATP-dependent DNA damage sensor activity 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0140939 histone H4 methyltransferase activity 1/1182 20/18639 0.05 0.788451776649746 0.730449524338682 0.999999996065309 GO:0015144 carbohydrate transmembrane transporter activity 2/1182 40/18639 0.05 0.788451776649746 0.730511430972668 0.999999996065309 GO:0071855 neuropeptide receptor binding 2/1182 40/18639 0.05 0.788451776649746 0.730511430972668 0.999999996065309 GO:0071949 FAD binding 2/1182 40/18639 0.05 0.788451776649746 0.730511430972668 0.999999996065309 GO:0140097 catalytic activity, acting on DNA 19/1182 336/18639 0.056547619047619 0.891701414068165 0.730707453058675 0.999999996065309 GO:0036002 pre-mRNA binding 3/1182 59/18639 0.0508474576271186 0.801815366084488 0.73141884914416 0.999999996065309 GO:0016874 ligase activity 9/1182 167/18639 0.0538922155688623 0.849828262257211 0.739141447352818 0.999999996065309 GO:1901981 phosphatidylinositol phosphate binding 10/1182 185/18639 0.0540540540540541 0.852380299080807 0.743015235282199 0.999999996065309 GO:0042287 MHC protein binding 2/1182 41/18639 0.0487804878048781 0.769221245511947 0.743016533701527 0.999999996065309 GO:0140318 protein transporter activity 2/1182 41/18639 0.0487804878048781 0.769221245511947 0.743016533701527 0.999999996065309 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1182 41/18639 0.0487804878048781 0.769221245511947 0.743016533701527 0.999999996065309 GO:0046332 SMAD binding 4/1182 79/18639 0.0506329113924051 0.798432178885819 0.746121802987895 0.999999996065309 GO:0001846 opsonin binding 1/1182 21/18639 0.0476190476190476 0.750906453952139 0.74756154228979 0.999999996065309 GO:0015174 basic amino acid transmembrane transporter activity 1/1182 21/18639 0.0476190476190476 0.750906453952139 0.74756154228979 0.999999996065309 GO:0019200 carbohydrate kinase activity 1/1182 21/18639 0.0476190476190476 0.750906453952139 0.74756154228979 0.999999996065309 GO:0035613 RNA stem-loop binding 1/1182 21/18639 0.0476190476190476 0.750906453952139 0.74756154228979 0.999999996065309 GO:0061891 calcium ion sensor activity 1/1182 21/18639 0.0476190476190476 0.750906453952139 0.74756154228979 0.999999996065309 GO:0019905 syntaxin binding 3/1182 61/18639 0.0491803278688525 0.775526337688275 0.751961554829767 0.999999996065309 GO:0004725 protein tyrosine phosphatase activity 5/1182 98/18639 0.0510204081632653 0.804542629234435 0.752374636703753 0.999999996065309 GO:0042626 ATPase-coupled transmembrane transporter activity 5/1182 98/18639 0.0510204081632653 0.804542629234435 0.752374636703753 0.999999996065309 GO:0003714 transcription corepressor activity 11/1182 204/18639 0.053921568627451 0.850291131681099 0.752640610043987 0.999999996065309 GO:0004520 DNA endonuclease activity 2/1182 42/18639 0.0476190476190476 0.750906453952139 0.755021008715752 0.999999996065309 GO:0015297 antiporter activity 7/1182 135/18639 0.0518518518518519 0.81765369430344 0.760012742585942 0.999999996065309 GO:0015179 L-amino acid transmembrane transporter activity 3/1182 62/18639 0.0483870967741935 0.763017848370722 0.761749724155171 0.999999996065309 GO:0001618 virus receptor activity 4/1182 81/18639 0.0493827160493827 0.778717804098515 0.763502444930587 0.999999996065309 GO:0004407 histone deacetylase activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0008093 cytoskeletal anchor activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0008649 rRNA methyltransferase activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0008970 phospholipase A1 activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0015377 chloride:monoatomic cation symporter activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0033558 protein lysine deacetylase activity 1/1182 22/18639 0.0454545454545455 0.71677434240886 0.7635880895566 0.999999996065309 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1182 43/18639 0.0465116279069767 0.733443513162555 0.766538000750339 0.999999996065309 GO:0140789 histone phosphatase activity 7/1182 136/18639 0.0514705882352941 0.811641534786503 0.76664196496074 0.999999996065309 GO:0140272 exogenous protein binding 4/1182 82/18639 0.0487804878048781 0.769221245511947 0.771838564505636 0.999999996065309 GO:0005158 insulin receptor binding 1/1182 23/18639 0.0434782608695652 0.685610240564997 0.778597966451057 0.999999996065309 GO:0005283 amino acid:sodium symporter activity 1/1182 23/18639 0.0434782608695652 0.685610240564997 0.778597966451057 0.999999996065309 GO:0016493 C-C chemokine receptor activity 1/1182 23/18639 0.0434782608695652 0.685610240564997 0.778597966451057 0.999999996065309 GO:0070577 lysine-acetylated histone binding 1/1182 23/18639 0.0434782608695652 0.685610240564997 0.778597966451057 0.999999996065309 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1182 23/18639 0.0434782608695652 0.685610240564997 0.778597966451057 0.999999996065309 GO:0003823 antigen binding 9/1182 174/18639 0.0517241379310345 0.815639768948013 0.78101639316369 0.999999996065309 GO:0140303 intramembrane lipid transporter activity 2/1182 45/18639 0.0444444444444444 0.700846023688663 0.788163753920108 0.999999996065309 GO:0160215 deacylase activity 3/1182 65/18639 0.0461538461538462 0.727801639984381 0.789241844081485 0.999999996065309 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 12/1182 229/18639 0.0524017467248908 0.826325006095804 0.791775157796577 0.999999996065309 GO:0004806 triacylglycerol lipase activity 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0019957 C-C chemokine binding 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0050699 WW domain binding 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0070300 phosphatidic acid binding 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0140033 acetylation-dependent protein binding 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0140612 DNA damage sensor activity 1/1182 24/18639 0.0416666666666667 0.657043147208122 0.792655615981291 0.999999996065309 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/1182 46/18639 0.0434782608695652 0.685610240564997 0.79830016413689 0.999999996065309 GO:0001848 complement binding 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0004709 MAP kinase kinase kinase activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0005537 D-mannose binding 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0008139 nuclear localization sequence binding 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0008483 transaminase activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0015662 P-type ion transporter activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0120020 cholesterol transfer activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0140358 P-type transmembrane transporter activity 1/1182 25/18639 0.04 0.630761421319797 0.805821399591827 0.999999996065309 GO:0050840 extracellular matrix binding 3/1182 67/18639 0.0447761194029851 0.706076217895295 0.806066091983634 0.999999996065309 GO:0001784 phosphotyrosine residue binding 2/1182 47/18639 0.0425531914893617 0.671022788638082 0.808004227566761 0.999999996065309 GO:0061733 protein-lysine-acetyltransferase activity 2/1182 47/18639 0.0425531914893617 0.671022788638082 0.808004227566761 0.999999996065309 GO:0061749 forked DNA-dependent helicase activity 2/1182 47/18639 0.0425531914893617 0.671022788638082 0.808004227566761 0.999999996065309 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/1182 47/18639 0.0425531914893617 0.671022788638082 0.808004227566761 0.999999996065309 GO:0005178 integrin binding 8/1182 161/18639 0.0496894409937888 0.78355456064571 0.808096851406939 0.999999996065309 GO:0061659 ubiquitin-like protein ligase activity 20/1182 372/18639 0.0537634408602151 0.847797609300802 0.808616732094482 0.999999996065309 GO:0005548 phospholipid transporter activity 3/1182 68/18639 0.0441176470588235 0.695692744102717 0.814045264047096 0.999999996065309 GO:0009378 four-way junction helicase activity 2/1182 48/18639 0.0416666666666667 0.657043147208122 0.817289960753456 0.999999996065309 GO:0036121 double-stranded DNA helicase activity 2/1182 48/18639 0.0416666666666667 0.657043147208122 0.817289960753456 0.999999996065309 GO:0043138 3'-5' DNA helicase activity 2/1182 48/18639 0.0416666666666667 0.657043147208122 0.817289960753456 0.999999996065309 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0004435 phosphatidylinositol phospholipase C activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0004950 chemokine receptor activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0008143 poly(A) binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0008157 protein phosphatase 1 binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0030247 polysaccharide binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0034237 protein kinase A regulatory subunit binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0050681 nuclear androgen receptor binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0050750 low-density lipoprotein particle receptor binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0070006 metalloaminopeptidase activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0070412 R-SMAD binding 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0120014 phospholipid transfer activity 1/1182 26/18639 0.0384615384615385 0.606501366653651 0.818151855468181 0.999999996065309 GO:0002039 p53 binding 3/1182 69/18639 0.0434782608695652 0.685610240564997 0.821744312348118 0.999999996065309 GO:0005496 steroid binding 5/1182 108/18639 0.0462962962962963 0.730047941342358 0.822564952936904 0.999999996065309 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0005044 scavenger receptor activity 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0005385 zinc ion transmembrane transporter activity 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0008395 steroid hydroxylase activity 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0035255 ionotropic glutamate receptor binding 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/1182 27/18639 0.037037037037037 0.584038353073886 0.829699940507487 0.999999996065309 GO:0032813 tumor necrosis factor receptor superfamily binding 2/1182 50/18639 0.04 0.630761421319797 0.834662263029014 0.999999996065309 GO:0042578 phosphoric ester hydrolase activity 19/1182 363/18639 0.0523415977961433 0.825376515501112 0.837259421230933 0.999999996065309 GO:0051019 mitogen-activated protein kinase binding 1/1182 28/18639 0.0357142857142857 0.563179840464104 0.840515256987186 0.999999996065309 GO:0051959 dynein light intermediate chain binding 1/1182 28/18639 0.0357142857142857 0.563179840464104 0.840515256987186 0.999999996065309 GO:0008509 monoatomic anion transmembrane transporter activity 7/1182 149/18639 0.0469798657718121 0.740827172691037 0.84089045526797 0.999999996065309 GO:0004521 RNA endonuclease activity 3/1182 73/18639 0.0410958904109589 0.648042556150476 0.84987148293441 0.999999996065309 GO:0004629 phospholipase C activity 1/1182 29/18639 0.0344827586206897 0.543759845965342 0.850644264898698 0.999999996065309 GO:0005416 amino acid:monoatomic cation symporter activity 1/1182 29/18639 0.0344827586206897 0.543759845965342 0.850644264898698 0.999999996065309 GO:0051861 glycolipid binding 1/1182 29/18639 0.0344827586206897 0.543759845965342 0.850644264898698 0.999999996065309 GO:0099604 ligand-gated calcium channel activity 1/1182 29/18639 0.0344827586206897 0.543759845965342 0.850644264898698 0.999999996065309 GO:0001664 G protein-coupled receptor binding 15/1182 297/18639 0.0505050505050505 0.796415936009845 0.852036129877822 0.999999996065309 GO:0030246 carbohydrate binding 14/1182 280/18639 0.05 0.788451776649746 0.854907683034528 0.999999996065309 GO:0031491 nucleosome binding 3/1182 74/18639 0.0405405405405405 0.639285224310605 0.856269657494236 0.999999996065309 GO:0051018 protein kinase A binding 2/1182 53/18639 0.0377358490566038 0.595057944641318 0.857928914838267 0.999999996065309 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/1182 30/18639 0.0333333333333333 0.525634517766497 0.860130480851935 0.999999996065309 GO:0031624 ubiquitin conjugating enzyme binding 1/1182 30/18639 0.0333333333333333 0.525634517766497 0.860130480851935 0.999999996065309 GO:0048019 receptor antagonist activity 1/1182 30/18639 0.0333333333333333 0.525634517766497 0.860130480851935 0.999999996065309 GO:0051721 protein phosphatase 2A binding 1/1182 30/18639 0.0333333333333333 0.525634517766497 0.860130480851935 0.999999996065309 GO:0070566 adenylyltransferase activity 1/1182 30/18639 0.0333333333333333 0.525634517766497 0.860130480851935 0.999999996065309 GO:0061630 ubiquitin protein ligase activity 18/1182 353/18639 0.0509915014164306 0.804086797716455 0.860882350416284 0.999999996065309 GO:0035401 histone H3Y41 kinase activity 5/1182 115/18639 0.0434782608695652 0.685610240564997 0.861422271004788 0.999999996065309 GO:0140801 histone H2AXY142 kinase activity 5/1182 115/18639 0.0434782608695652 0.685610240564997 0.861422271004788 0.999999996065309 GO:0004896 cytokine receptor activity 4/1182 96/18639 0.0416666666666667 0.657043147208122 0.865646013088671 0.999999996065309 GO:0015294 solute:monoatomic cation symporter activity 5/1182 116/18639 0.0431034482758621 0.679699807456678 0.866345323108087 0.999999996065309 GO:0004386 helicase activity 7/1182 155/18639 0.0451612903225806 0.712149991812674 0.868140435382388 0.999999996065309 GO:0005184 neuropeptide hormone activity 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0005452 solute:inorganic anion antiporter activity 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0047499 calcium-independent phospholipase A2 activity 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0070325 lipoprotein particle receptor binding 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0072349 modified amino acid transmembrane transporter activity 1/1182 31/18639 0.032258064516129 0.508678565580481 0.869014664399305 0.999999996065309 GO:0005543 phospholipid binding 26/1182 497/18639 0.0523138832997988 0.824939484623477 0.870985437909376 0.999999996065309 GO:0140375 immune receptor activity 7/1182 156/18639 0.0448717948717949 0.707584927762593 0.872286753616014 0.999999996065309 GO:0008170 N-methyltransferase activity 4/1182 98/18639 0.0408163265306122 0.643634103387548 0.875905726314175 0.999999996065309 GO:0047498 calcium-dependent phospholipase A2 activity 1/1182 32/18639 0.03125 0.492782360406091 0.877334992574285 0.999999996065309 GO:0071813 lipoprotein particle binding 1/1182 32/18639 0.03125 0.492782360406091 0.877334992574285 0.999999996065309 GO:0071814 protein-lipid complex binding 1/1182 32/18639 0.03125 0.492782360406091 0.877334992574285 0.999999996065309 GO:0120015 sterol transfer activity 1/1182 32/18639 0.03125 0.492782360406091 0.877334992574285 0.999999996065309 GO:0160041 neuropeptide activity 1/1182 32/18639 0.03125 0.492782360406091 0.877334992574285 0.999999996065309 GO:0008514 organic anion transmembrane transporter activity 13/1182 269/18639 0.0483271375464684 0.762072349178193 0.877792049508438 0.999999996065309 GO:0140416 transcription regulator inhibitor activity 1/1182 33/18639 0.0303030303030303 0.477849561605907 0.885127223389418 0.999999996065309 GO:0015108 chloride transmembrane transporter activity 5/1182 121/18639 0.0413223140495868 0.651613038553509 0.888798844150013 0.999999996065309 GO:0008175 tRNA methyltransferase activity 1/1182 34/18639 0.0294117647058824 0.463795162735145 0.892424848991574 0.999999996065309 GO:0016831 carboxy-lyase activity 1/1182 34/18639 0.0294117647058824 0.463795162735145 0.892424848991574 0.999999996065309 GO:0008238 exopeptidase activity 4/1182 102/18639 0.0392156862745098 0.618393550313526 0.89440457282678 0.999999996065309 GO:0015171 amino acid transmembrane transporter activity 4/1182 102/18639 0.0392156862745098 0.618393550313526 0.89440457282678 0.999999996065309 GO:0031593 polyubiquitin modification-dependent protein binding 2/1182 59/18639 0.0338983050847458 0.534543577389658 0.895709122658809 0.999999996065309 GO:0005253 monoatomic anion channel activity 4/1182 103/18639 0.0388349514563107 0.612389729436696 0.898633277181931 0.999999996065309 GO:0004623 phospholipase A2 activity 1/1182 35/18639 0.0285714285714286 0.450543872371284 0.899259239128202 0.999999996065309 GO:0005343 organic acid:sodium symporter activity 1/1182 35/18639 0.0285714285714286 0.450543872371284 0.899259239128202 0.999999996065309 GO:0043015 gamma-tubulin binding 1/1182 35/18639 0.0285714285714286 0.450543872371284 0.899259239128202 0.999999996065309 GO:0140566 histone reader activity 1/1182 35/18639 0.0285714285714286 0.450543872371284 0.899259239128202 0.999999996065309 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/1182 60/18639 0.0333333333333333 0.525634517766497 0.901014513622684 0.999999996065309 GO:0001217 DNA-binding transcription repressor activity 13/1182 278/18639 0.0467625899280576 0.73740094219041 0.903067021248829 0.999999996065309 GO:0001540 amyloid-beta binding 3/1182 83/18639 0.036144578313253 0.569965139746804 0.90386208693002 0.999999996065309 GO:0015026 coreceptor activity 2/1182 61/18639 0.0327868852459016 0.51701755845885 0.90606715629363 0.999999996065309 GO:0005539 glycosaminoglycan binding 11/1182 242/18639 0.0454545454545455 0.71677434240886 0.906320946953067 0.999999996065309 GO:0019783 ubiquitin-like protein peptidase activity 5/1182 127/18639 0.0393700787401575 0.620828170590351 0.911391240790653 0.999999996065309 GO:0019213 deacetylase activity 1/1182 37/18639 0.027027027027027 0.426190149540403 0.911653977833209 0.999999996065309 GO:0030280 structural constituent of skin epidermis 1/1182 37/18639 0.027027027027027 0.426190149540403 0.911653977833209 0.999999996065309 GO:0030551 cyclic nucleotide binding 1/1182 37/18639 0.027027027027027 0.426190149540403 0.911653977833209 0.999999996065309 GO:0005516 calmodulin binding 9/1182 207/18639 0.0434782608695652 0.685610240564997 0.914273943611555 0.999999996065309 GO:0005109 frizzled binding 1/1182 38/18639 0.0263157894736842 0.41497461928934 0.917267621430733 0.999999996065309 GO:0042393 histone binding 11/1182 247/18639 0.0445344129554656 0.702264740335806 0.918802435320756 0.999999996065309 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 12/1182 268/18639 0.0447761194029851 0.706076217895295 0.923487754053462 0.999999996065309 GO:0004197 cysteine-type endopeptidase activity 3/1182 88/18639 0.0340909090909091 0.537580756806645 0.923661967742524 0.999999996065309 GO:0038024 cargo receptor activity 2/1182 65/18639 0.0307692307692308 0.485201093322921 0.923958913767817 0.999999996065309 GO:0120013 lipid transfer activity 2/1182 65/18639 0.0307692307692308 0.485201093322921 0.923958913767817 0.999999996065309 GO:0004222 metalloendopeptidase activity 4/1182 110/18639 0.0363636363636364 0.573419473927088 0.924265829917521 0.999999996065309 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/1182 89/18639 0.0337078651685393 0.531540523584099 0.927143791791149 0.999999996065309 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/1182 89/18639 0.0337078651685393 0.531540523584099 0.927143791791149 0.999999996065309 GO:0005096 GTPase activator activity 12/1182 271/18639 0.044280442804428 0.698259875999775 0.929737431012229 0.999999996065309 GO:0008236 serine-type peptidase activity 8/1182 194/18639 0.0412371134020619 0.650269506515255 0.930432491201792 0.999999996065309 GO:0140793 histone H2AXY142 phosphatase activity 3/1182 90/18639 0.0333333333333333 0.525634517766497 0.930479272866734 0.999999996065309 GO:0008173 RNA methyltransferase activity 2/1182 67/18639 0.0298507462686567 0.470717478596863 0.931650145850266 0.999999996065309 GO:0042054 histone methyltransferase activity 2/1182 67/18639 0.0298507462686567 0.470717478596863 0.931650145850266 0.999999996065309 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1182 41/18639 0.024390243902439 0.384610622755974 0.932059062333665 0.999999996065309 GO:0042169 SH2 domain binding 1/1182 41/18639 0.024390243902439 0.384610622755974 0.932059062333665 0.999999996065309 GO:0003777 microtubule motor activity 2/1182 68/18639 0.0294117647058824 0.463795162735145 0.935213930147332 0.999999996065309 GO:1990841 promoter-specific chromatin binding 2/1182 68/18639 0.0294117647058824 0.463795162735145 0.935213930147332 0.999999996065309 GO:0004402 histone acetyltransferase activity 1/1182 42/18639 0.0238095238095238 0.37545322697607 0.936377063641419 0.999999996065309 GO:1901681 sulfur compound binding 12/1182 275/18639 0.0436363636363636 0.688103368712506 0.93738882129679 0.999999996065309 GO:0101005 deubiquitinase activity 4/1182 115/18639 0.0347826086956522 0.548488192451997 0.9388370563711 0.999999996065309 GO:0017171 serine hydrolase activity 8/1182 198/18639 0.0404040404040404 0.637132748807876 0.939190832648275 0.999999996065309 GO:0008375 acetylglucosaminyltransferase activity 1/1182 43/18639 0.0232558139534884 0.366721756581277 0.940420850853111 0.999999996065309 GO:0016278 lysine N-methyltransferase activity 2/1182 70/18639 0.0285714285714286 0.450543872371284 0.941819650563251 0.999999996065309 GO:0016782 transferase activity, transferring sulphur-containing groups 2/1182 70/18639 0.0285714285714286 0.450543872371284 0.941819650563251 0.999999996065309 GO:0042562 hormone binding 3/1182 94/18639 0.0319148936170213 0.503267091478561 0.942462184014 0.999999996065309 GO:0001223 transcription coactivator binding 1/1182 44/18639 0.0227272727272727 0.35838717120443 0.94420782408884 0.999999996065309 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/1182 44/18639 0.0227272727272727 0.35838717120443 0.94420782408884 0.999999996065309 GO:0043014 alpha-tubulin binding 1/1182 44/18639 0.0227272727272727 0.35838717120443 0.94420782408884 0.999999996065309 GO:0004713 protein tyrosine kinase activity 5/1182 140/18639 0.0357142857142857 0.563179840464104 0.946996767931111 0.999999996065309 GO:0004180 carboxypeptidase activity 1/1182 46/18639 0.0217391304347826 0.342805120282498 0.951075482808865 0.999999996065309 GO:0008237 metallopeptidase activity 7/1182 184/18639 0.0380434782608696 0.599908960494372 0.951182050950266 0.999999996065309 GO:0016887 ATP hydrolysis activity 19/1182 417/18639 0.0455635491606715 0.718493225723989 0.952448617614358 0.999999996065309 GO:0140938 histone H3 methyltransferase activity 1/1182 47/18639 0.0212765957446809 0.335511394319041 0.954185727488041 0.999999996065309 GO:0015103 inorganic anion transmembrane transporter activity 6/1182 165/18639 0.0363636363636364 0.573419473927088 0.954383770411101 0.999999996065309 GO:0016757 glycosyltransferase activity 11/1182 267/18639 0.0411985018726592 0.64966063993612 0.955587214453297 0.999999996065309 GO:0015291 secondary active transmembrane transporter activity 12/1182 287/18639 0.0418118466898955 0.659332496153098 0.956187882877938 0.999999996065309 GO:0008234 cysteine-type peptidase activity 7/1182 187/18639 0.0374331550802139 0.590284752572002 0.956269025305549 0.999999996065309 GO:0038187 pattern recognition receptor activity 1/1182 48/18639 0.0208333333333333 0.328521573604061 0.95709840337601 0.999999996065309 GO:0046943 carboxylic acid transmembrane transporter activity 7/1182 188/18639 0.0372340425531915 0.587144940058322 0.957855608962034 0.999999996065309 GO:0140597 protein carrier chaperone 7/1182 188/18639 0.0372340425531915 0.587144940058322 0.957855608962034 0.999999996065309 GO:0015293 symporter activity 5/1182 146/18639 0.0342465753424658 0.54003546345873 0.958568622770247 0.999999996065309 GO:0005342 organic acid transmembrane transporter activity 7/1182 189/18639 0.037037037037037 0.584038353073886 0.959390129566025 0.999999996065309 GO:0005004 GPI-linked ephrin receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005008 hepatocyte growth factor receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005009 insulin receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005011 macrophage colony-stimulating factor receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005020 stem cell factor receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0008288 boss receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0036332 placental growth factor receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0038062 protein tyrosine kinase collagen receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0060175 brain-derived neurotrophic factor receptor activity 1/1182 49/18639 0.0204081632653061 0.321817051693774 0.959826050474583 0.999999996065309 GO:0005006 epidermal growth factor receptor activity 1/1182 50/18639 0.02 0.315380710659898 0.962380413483676 0.999999996065309 GO:0005007 fibroblast growth factor receptor activity 1/1182 50/18639 0.02 0.315380710659898 0.962380413483676 0.999999996065309 GO:0005017 platelet-derived growth factor receptor activity 1/1182 50/18639 0.02 0.315380710659898 0.962380413483676 0.999999996065309 GO:0005019 platelet-derived growth factor beta-receptor activity 1/1182 50/18639 0.02 0.315380710659898 0.962380413483676 0.999999996065309 GO:0015370 solute:sodium symporter activity 2/1182 79/18639 0.0253164556962025 0.399216089442909 0.964380747589142 0.999999996065309 GO:0005010 insulin-like growth factor receptor activity 1/1182 51/18639 0.0196078431372549 0.309196775156763 0.964772492200245 0.999999996065309 GO:0005021 vascular endothelial growth factor receptor activity 1/1182 51/18639 0.0196078431372549 0.309196775156763 0.964772492200245 0.999999996065309 GO:0005030 neurotrophin receptor activity 1/1182 51/18639 0.0196078431372549 0.309196775156763 0.964772492200245 0.999999996065309 GO:0016597 amino acid binding 1/1182 51/18639 0.0196078431372549 0.309196775156763 0.964772492200245 0.999999996065309 GO:0008201 heparin binding 6/1182 172/18639 0.0348837209302326 0.550082634871916 0.965333844234534 0.999999996065309 GO:0030159 signaling receptor complex adaptor activity 1/1182 52/18639 0.0192307692307692 0.303250683326825 0.967012588725923 0.999999996065309 GO:0004497 monooxygenase activity 3/1182 106/18639 0.0283018867924528 0.446293458480988 0.967870652214583 0.999999996065309 GO:0015101 organic cation transmembrane transporter activity 2/1182 81/18639 0.0246913580246914 0.389358902049257 0.968103634007326 0.999999996065309 GO:0030971 receptor tyrosine kinase binding 2/1182 81/18639 0.0246913580246914 0.389358902049257 0.968103634007326 0.999999996065309 GO:0005003 ephrin receptor activity 1/1182 53/18639 0.0188679245283019 0.297528972320659 0.969110351685301 0.999999996065309 GO:0005005 transmembrane-ephrin receptor activity 1/1182 53/18639 0.0188679245283019 0.297528972320659 0.969110351685301 0.999999996065309 GO:0008146 sulfotransferase activity 1/1182 53/18639 0.0188679245283019 0.297528972320659 0.969110351685301 0.999999996065309 GO:0017046 peptide hormone binding 1/1182 53/18639 0.0188679245283019 0.297528972320659 0.969110351685301 0.999999996065309 GO:0038064 collagen receptor activity 1/1182 53/18639 0.0188679245283019 0.297528972320659 0.969110351685301 0.999999996065309 GO:0004843 cysteine-type deubiquitinase activity 3/1182 108/18639 0.0277777777777778 0.438028764805415 0.97090234848654 0.999999996065309 GO:0005254 chloride channel activity 2/1182 83/18639 0.0240963855421687 0.379976759831203 0.971450279845758 0.999999996065309 GO:0004620 phospholipase activity 3/1182 109/18639 0.0275229357798165 0.434010152284264 0.972314653246958 0.999999996065309 GO:0005319 lipid transporter activity 6/1182 178/18639 0.0337078651685393 0.531540523584099 0.972746003028981 0.999999996065309 GO:0035091 phosphatidylinositol binding 11/1182 284/18639 0.0387323943661972 0.610772503038536 0.974360111173579 0.999999996065309 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/1182 181/18639 0.0331491712707182 0.52273045965729 0.975876690243258 0.999999996065309 GO:0008081 phosphoric diester hydrolase activity 2/1182 87/18639 0.0229885057471264 0.362506563976895 0.977156318105014 0.999999996065309 GO:0070888 E-box binding 1/1182 59/18639 0.0169491525423729 0.267271788694829 0.979175815384287 0.999999996065309 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/1182 60/18639 0.0166666666666667 0.262817258883249 0.980500583210755 0.999999996065309 GO:0140713 histone chaperone activity 5/1182 164/18639 0.0304878048780488 0.480763278444967 0.980801533044712 0.999999996065309 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1182 91/18639 0.021978021978022 0.346572209516372 0.981751228936532 0.999999996065309 GO:0008094 ATP-dependent activity, acting on DNA 7/1182 210/18639 0.0333333333333333 0.525634517766497 0.981903843951135 0.999999996065309 GO:1901682 sulfur compound transmembrane transporter activity 1/1182 63/18639 0.0158730158730159 0.25030215131738 0.983990677868692 0.999999996065309 GO:0008235 metalloexopeptidase activity 1/1182 66/18639 0.0151515151515152 0.238924780802953 0.986856532162106 0.999999996065309 GO:0140030 modification-dependent protein binding 5/1182 173/18639 0.0289017341040462 0.455752472051876 0.987128227380527 0.999999996065309 GO:0016500 protein-hormone receptor activity 1/1182 67/18639 0.0149253731343284 0.235358739298432 0.98769299256077 0.999999996065309 GO:0004252 serine-type endopeptidase activity 5/1182 176/18639 0.0284090909090909 0.447983964005538 0.988757091825424 0.999999996065309 GO:0016279 protein-lysine N-methyltransferase activity 1/1182 69/18639 0.0144927536231884 0.228536746854999 0.989209720667142 0.999999996065309 GO:0004674 protein serine/threonine kinase activity 17/1182 433/18639 0.0392609699769053 0.619107630625667 0.989764348571208 0.999999996065309 GO:0035591 signaling adaptor activity 3/1182 129/18639 0.0232558139534884 0.366721756581277 0.990016054638239 0.999999996065309 GO:0035402 histone H3T11 kinase activity 8/1182 247/18639 0.0323886639676113 0.510737992971496 0.99006945438179 0.999999996065309 GO:0016298 lipase activity 3/1182 130/18639 0.0230769230769231 0.363900819992191 0.990523064929735 0.999999996065309 GO:0005518 collagen binding 1/1182 72/18639 0.0138888888888889 0.219014382402707 0.991141889345777 0.999999996065309 GO:0003689 DNA clamp loader activity 4/1182 160/18639 0.025 0.394225888324873 0.992391229784354 0.999999996065309 GO:0004175 endopeptidase activity 15/1182 405/18639 0.037037037037037 0.584038353073886 0.993124963940261 0.999999996065309 GO:0003724 RNA helicase activity 1/1182 77/18639 0.012987012987013 0.204792669259674 0.993624856230015 0.999999996065309 GO:0019199 transmembrane receptor protein kinase activity 1/1182 78/18639 0.0128205128205128 0.202167122217884 0.994030815713698 0.999999996065309 GO:0008186 ATP-dependent activity, acting on RNA 1/1182 79/18639 0.0126582278481013 0.199608044721455 0.994410944792218 0.999999996065309 GO:0005201 extracellular matrix structural constituent 4/1182 168/18639 0.0238095238095238 0.37545322697607 0.994872225799496 0.999999996065309 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 7/1182 243/18639 0.0288065843621399 0.4542520523908 0.995396406951994 0.999999996065309 GO:0030165 PDZ domain binding 1/1182 83/18639 0.0120481927710843 0.189988379915601 0.995704476167682 0.999999996065309 GO:0016758 hexosyltransferase activity 5/1182 197/18639 0.0253807106598985 0.400229328248602 0.995749980644506 0.999999996065309 GO:0004676 3-phosphoinositide-dependent protein kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0004711 ribosomal protein S6 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0035175 histone H3S10 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0035979 histone H2AXS139 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0044022 histone H3S28 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0044023 histone H4S1 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0044024 histone H2AS1 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0044025 histone H2BS14 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0072354 histone H3T3 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0072371 histone H2AS121 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0072518 Rho-dependent protein serine/threonine kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0140823 histone H2BS36 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0140855 histone H3S57 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0140995 histone H2A kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0140997 histone H4 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:0140998 histone H2B kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:1990244 histone H2AT120 kinase activity 7/1182 245/18639 0.0285714285714286 0.450543872371284 0.99577716543668 0.999999996065309 GO:1990782 protein tyrosine kinase binding 2/1182 117/18639 0.0170940170940171 0.269556162957178 0.99589531060419 0.999999996065309 GO:0004677 DNA-dependent protein kinase activity 7/1182 246/18639 0.0284552845528455 0.448712393215303 0.995956102742577 0.999999996065309 GO:0140857 histone H3T45 kinase activity 7/1182 246/18639 0.0284552845528455 0.448712393215303 0.995956102742577 0.999999996065309 GO:0035403 histone H3T6 kinase activity 7/1182 247/18639 0.0283400809716599 0.446895743850059 0.9961277966531 0.999999996065309 GO:0015085 calcium ion transmembrane transporter activity 3/1182 147/18639 0.0204081632653061 0.321817051693774 0.996146333273491 0.999999996065309 GO:0004679 AMP-activated protein kinase activity 7/1182 248/18639 0.0282258064516129 0.445093744882921 0.996292523097439 0.999999996065309 GO:0035173 histone kinase activity 12/1182 360/18639 0.0333333333333333 0.525634517766497 0.996342517924157 0.999999996065309 GO:0106310 protein serine kinase activity 12/1182 361/18639 0.0332409972299169 0.524178466470745 0.996476207547498 0.999999996065309 GO:0141003 histone H2AX kinase activity 11/1182 354/18639 0.0310734463276836 0.489998279273854 0.998007949970426 0.999999996065309 GO:0005262 calcium channel activity 2/1182 131/18639 0.0152671755725191 0.240748634091526 0.9981953615162 0.999999996065309 GO:0140996 histone H3 kinase activity 11/1182 357/18639 0.030812324929972 0.485880646674914 0.99823059277665 0.999999996065309 GO:0030594 neurotransmitter receptor activity 1/1182 97/18639 0.0103092783505155 0.162567376628814 0.998291214658041 0.999999996065309 GO:0030527 structural constituent of chromatin 1/1182 98/18639 0.0102040816326531 0.160908525846887 0.998400144885319 0.999999996065309 GO:0008194 UDP-glycosyltransferase activity 2/1182 145/18639 0.0137931034482759 0.217503938386137 0.99921446990307 0.999999996065309 GO:0000510 H3-H4 histone complex chaperone activity 2/1182 151/18639 0.0132450331125828 0.208861397788012 0.999451474105736 0.999999996065309 GO:0140584 chromatin extrusion motor activity 2/1182 151/18639 0.0132450331125828 0.208861397788012 0.999451474105736 0.999999996065309 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/1182 151/18639 0.0132450331125828 0.208861397788012 0.999451474105736 0.999999996065309 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/1182 151/18639 0.0132450331125828 0.208861397788012 0.999451474105736 0.999999996065309 GO:0015616 DNA translocase activity 2/1182 152/18639 0.0131578947368421 0.20748730964467 0.999483416188814 0.999999996065309 GO:0140674 ATP-dependent histone chaperone activity 2/1182 152/18639 0.0131578947368421 0.20748730964467 0.999483416188814 0.999999996065309 GO:0061775 cohesin loader activity 2/1182 153/18639 0.0130718954248366 0.206131183437842 0.999513517487145 0.999999996065309 GO:0140658 ATP-dependent chromatin remodeler activity 2/1182 158/18639 0.0126582278481013 0.199608044721455 0.999639879724912 0.999999996065309 GO:0045182 translation regulator activity 9/1182 356/18639 0.0252808988764045 0.398655392688074 0.999742035413408 0.999999996065309 GO:0015081 sodium ion transmembrane transporter activity 2/1182 164/18639 0.0121951219512195 0.192305311377987 0.999749289465094 0.999999996065309 GO:0005244 voltage-gated monoatomic ion channel activity 2/1182 173/18639 0.0115606936416185 0.182300988820751 0.999854707242419 0.999999996065309 GO:0099094 ligand-gated monoatomic cation channel activity 1/1182 136/18639 0.00735294117647059 0.115948790683786 0.99986943201013 0.999999996065309 GO:0022832 voltage-gated channel activity 2/1182 175/18639 0.0114285714285714 0.180217548948513 0.99987134208347 0.999999996065309 GO:0001216 DNA-binding transcription activator activity 14/1182 491/18639 0.0285132382892057 0.449626267743236 0.999877020162332 0.999999996065309 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 13/1182 484/18639 0.0268595041322314 0.423548475059781 0.999937566883033 0.999999996065309 GO:0015276 ligand-gated monoatomic ion channel activity 1/1182 186/18639 0.00537634408602151 0.0847797609300802 0.99999520916043 0.999999996065309 GO:0022834 ligand-gated channel activity 1/1182 188/18639 0.00531914893617021 0.0838778485797602 0.999995803270072 0.999999996065309 GO:0030371 translation repressor activity 4/1182 329/18639 0.0121580547112462 0.191720796753738 0.999999211635652 0.999999996065309 GO:0046873 metal ion transmembrane transporter activity 8/1182 450/18639 0.0177777777777778 0.280338409475465 0.999999247136277 0.999999996065309 GO:0022836 gated channel activity 3/1182 318/18639 0.00943396226415094 0.148764486160329 0.9999998048045 0.999999996065309 GO:0005216 monoatomic ion channel activity 6/1182 448/18639 0.0133928571428571 0.211192440174039 0.999999965358323 0.999999996065309 GO:0005261 monoatomic cation channel activity 2/1182 341/18639 0.00586510263929619 0.0924870119237239 0.999999996065309 0.999999996065309