ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0005539 glycosaminoglycan binding 8/83 230/18367 9.41722807465234e-06 0.0013613046441159 LRPAP1/APLP2/NRP2/APP/SERPINE2/PRG2/ADGRG1/ENG 8 GO:0008201 heparin binding 7/83 166/18367 1.01212241198208e-05 0.0013613046441159 LRPAP1/APLP2/NRP2/APP/SERPINE2/PRG2/ADGRG1 7 GO:0004867 serine-type endopeptidase inhibitor activity 5/83 98/18367 8.15137201551142e-05 0.00730906357390857 APLP2/SPINT1/APP/SERPINF1/SERPINE2 5 GO:0050840 extracellular matrix binding 4/83 56/18367 0.000119071124167316 0.00778464145110393 ITGAV/TINAGL1/ADGRG1/TGFBI 4 GO:0004866 endopeptidase inhibitor activity 6/83 180/18367 0.000164690911467434 0.00778464145110393 APLP2/SPINT1/GAPDH/APP/SERPINF1/SERPINE2 6 GO:1901681 sulfur compound binding 7/83 265/18367 0.00019616901133913 0.00778464145110393 LRPAP1/APLP2/NRP2/APP/SERPINE2/PRG2/ADGRG1 7 GO:0030414 peptidase inhibitor activity 6/83 187/18367 0.000202574312854006 0.00778464145110393 APLP2/SPINT1/GAPDH/APP/SERPINF1/SERPINE2 6 GO:0061135 endopeptidase regulator activity 6/83 194/18367 0.000247028806930055 0.00830634363302309 APLP2/SPINT1/GAPDH/APP/SERPINF1/SERPINE2 6 GO:0019955 cytokine binding 5/83 139/18367 0.000417718954893873 0.0119965445002279 CSF3R/NRP2/EBI3/ITGAV/ENG 5 GO:0019838 growth factor binding 5/83 141/18367 0.000445968197034495 0.0119965445002279 FLT1/HTRA1/NRP2/ITGAV/ENG 5 GO:0005178 integrin binding 5/83 144/18367 0.000491015215438431 0.0120075539048125 IGF2/UTRN/ITGAV/ISG15/TGFBI 5 GO:0061134 peptidase regulator activity 6/83 230/18367 0.000610595295304673 0.0136875112030797 APLP2/SPINT1/GAPDH/APP/SERPINF1/SERPINE2 6 GO:0005201 extracellular matrix structural constituent 5/83 172/18367 0.00109450412909061 0.0226478162096441 FBN2/PRG2/TINAGL1/TGFBI/COL14A1 5 GO:0017154 semaphorin receptor activity 2/83 12/18367 0.00129304402828998 0.0238359915698945 NRP2/MET 2 GO:0015026 coreceptor activity 3/83 48/18367 0.00132914451133241 0.0238359915698945 ITGAV/LRP5/ENG 3 GO:0048185 activin binding 2/83 15/18367 0.00203908806811674 0.0328437125135699 FSTL3/ENG 2 GO:0051287 NAD binding 3/83 56/18367 0.00207562495438918 0.0328437125135699 LDHA/GAPDH/PARP1 3 GO:0005518 collagen binding 3/83 69/18367 0.00376147511461185 0.0522222644667078 ADGRG1/TGFBI/COL14A1 3 GO:0045296 cadherin binding 6/83 332/18367 0.00391878623602907 0.0522222644667078 LDHA/ALDOA/EFHD2/PDLIM1/S100P/FXYD5 6 GO:0019199 transmembrane receptor protein kinase activity 4/83 143/18367 0.00402347995187661 0.0522222644667078 FLT1/NRP2/MET/ENG 4 GO:0048029 monosaccharide binding 3/83 71/18367 0.0040768310550218 0.0522222644667078 ALDOA/EGLN3/ENG 3 GO:0070412 R-SMAD binding 2/83 23/18367 0.00479945640584938 0.0586842624169765 JUN/PARP1 2 GO:0050431 transforming growth factor beta binding 2/83 24/18367 0.00522048240409735 0.0610569463783559 ITGAV/ENG 2 GO:0048027 mRNA 5'-UTR binding 2/83 27/18367 0.00658114272765417 0.0737636414057905 MYH10/DHX36 2 GO:0001968 fibronectin binding 2/83 28/18367 0.00706671748492504 0.0760378801377934 ITGAV/FSTL3 2 GO:0005520 insulin-like growth factor binding 2/83 29/18367 0.00756805236467138 0.0765355741395698 HTRA1/ITGAV 2 GO:0030246 carbohydrate binding 5/83 271/18367 0.00768200930025422 0.0765355741395698 ALDOA/AGL/EGLN3/PRG2/ENG 5 GO:0017147 Wnt-protein binding 2/83 30/18367 0.00808499854996645 0.0776737360693205 WLS/LRP5 2 GO:0003735 structural constituent of ribosome 4/83 182/18367 0.00933522861238953 0.0865922929907856 RPS21/RPS29/ISG15/RPL37A 4 GO:0005516 calmodulin binding 4/83 201/18367 0.0130659406441352 0.117157934442412 MYH10/KCNN4/IQGAP2/ATP2B1 4 GO:0003779 actin binding 6/83 440/18367 0.0146438929037186 0.127071199712913 ALDOA/PDLIM1/UTRN/MYH10/IQGAP2/FXYD5 6 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/83 124/18367 0.0186546354789129 0.156815529494612 FLT1/NRP2/MET 3 GO:0017046 peptide hormone binding 2/83 52/18367 0.0231185522658074 0.187802650091986 EBI3/SLC40A1 2 GO:0004713 protein tyrosine kinase activity 3/83 136/18367 0.0237371379298421 0.187802650091986 FLT1/NRP2/MET 3 GO:0030546 signaling receptor activator activity 6/83 495/18367 0.024546424915647 0.188656808637401 IGF2/LRPAP1/TNFSF10/EBI3/APP/SEMA6A 6 GO:0019531 oxalate transmembrane transporter activity 1/83 10/18367 0.0442924115782192 0.285024168733777 SLC26A2 1 GO:0034511 U3 snoRNA binding 1/83 10/18367 0.0442924115782192 0.285024168733777 PRKDC 1 GO:0034713 type I transforming growth factor beta receptor binding 1/83 10/18367 0.0442924115782192 0.285024168733777 ENG 1 GO:0035612 AP-2 adaptor complex binding 1/83 10/18367 0.0442924115782192 0.285024168733777 AAK1 1 GO:0051880 G-quadruplex DNA binding 1/83 10/18367 0.0442924115782192 0.285024168733777 DHX36 1 GO:0016832 aldehyde-lyase activity 1/83 11/18367 0.0486135822400382 0.285024168733777 ALDOA 1 GO:0097493 structural molecule activity conferring elasticity 1/83 11/18367 0.0486135822400382 0.285024168733777 FBN2 1 GO:0046332 SMAD binding 2/83 79/18367 0.049695015696291 0.285024168733777 JUN/PARP1 2 GO:0005024 transforming growth factor beta-activated receptor activity 1/83 12/18367 0.0529154493501971 0.285024168733777 ENG 1 GO:0005095 GTPase inhibitor activity 1/83 12/18367 0.0529154493501971 0.285024168733777 IQGAP2 1 GO:0015269 calcium-activated potassium channel activity 1/83 12/18367 0.0529154493501971 0.285024168733777 KCNN4 1 GO:0017166 vinculin binding 1/83 12/18367 0.0529154493501971 0.285024168733777 UTRN 1 GO:0031543 peptidyl-proline dioxygenase activity 1/83 12/18367 0.0529154493501971 0.285024168733777 EGLN3 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/83 13/18367 0.0571980980946228 0.285024168733777 SLC26A2 1 GO:0016840 carbon-nitrogen lyase activity 1/83 13/18367 0.0571980980946228 0.285024168733777 APMAP 1 GO:0031386 protein tag 1/83 13/18367 0.0571980980946228 0.285024168733777 ISG15 1 GO:0031994 insulin-like growth factor I binding 1/83 13/18367 0.0571980980946228 0.285024168733777 ITGAV 1 GO:0042277 peptide binding 4/83 321/18367 0.0575450674556817 0.285024168733777 LRPAP1/EBI3/HLA-C/SLC40A1 4 GO:0042562 hormone binding 2/83 86/18367 0.0577829221692992 0.285024168733777 EBI3/SLC40A1 2 GO:0015926 glucosidase activity 1/83 14/18367 0.0614616132879403 0.285024168733777 AGL 1 GO:0071837 HMG box domain binding 1/83 14/18367 0.0614616132879403 0.285024168733777 JUN 1 GO:0001846 opsonin binding 1/83 15/18367 0.0657060793750702 0.285024168733777 ITGAV 1 GO:0042813 Wnt-activated receptor activity 1/83 15/18367 0.0657060793750702 0.285024168733777 LRP5 1 GO:0051371 muscle alpha-actinin binding 1/83 15/18367 0.0657060793750702 0.285024168733777 PDLIM1 1 GO:0071933 Arp2/3 complex binding 1/83 15/18367 0.0657060793750702 0.285024168733777 IQGAP2 1 GO:0048018 receptor ligand activity 5/83 487/18367 0.0695126025102863 0.285024168733777 IGF2/LRPAP1/TNFSF10/EBI3/SEMA6A 5 GO:0005159 insulin-like growth factor receptor binding 1/83 16/18367 0.0699315804328225 0.285024168733777 IGF2 1 GO:0016208 AMP binding 1/83 16/18367 0.0699315804328225 0.285024168733777 ACSS1 1 GO:0035497 cAMP response element binding 1/83 16/18367 0.0699315804328225 0.285024168733777 JUN 1 GO:0036122 BMP binding 1/83 16/18367 0.0699315804328225 0.285024168733777 ENG 1 GO:1990404 protein ADP-ribosylase activity 1/83 16/18367 0.0699315804328225 0.285024168733777 PARP1 1 GO:0004896 cytokine receptor activity 2/83 97/18367 0.0713319378063152 0.286392407013415 CSF3R/EBI3 2 GO:0015108 chloride transmembrane transporter activity 1/83 17/18367 0.0741382001714784 0.289031534001851 SLC26A2 1 GO:0015116 sulfate transmembrane transporter activity 1/83 17/18367 0.0741382001714784 0.289031534001851 SLC26A2 1 GO:0051015 actin filament binding 3/83 217/18367 0.0752541981721174 0.289191132975708 UTRN/MYH10/IQGAP2 3 GO:0008301 DNA binding, bending 1/83 18/18367 0.0783260219363705 0.291534773328954 TFAM 1 GO:0098641 cadherin binding involved in cell-cell adhesion 1/83 18/18367 0.0783260219363705 0.291534773328954 PDLIM1 1 GO:0005200 structural constituent of cytoskeleton 2/83 103/18367 0.0791153845836939 0.291534773328954 KRT19/TUBB2A 2 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/83 19/18367 0.0824951287094525 0.29588252830457 ENG 1 GO:0035613 RNA stem-loop binding 1/83 19/18367 0.0824951287094525 0.29588252830457 MYH10 1 GO:0016500 protein-hormone receptor activity 1/83 20/18367 0.0866456031108646 0.29918256435883 LGR5 1 GO:0031418 L-ascorbic acid binding 1/83 20/18367 0.0866456031108646 0.29918256435883 EGLN3 1 GO:0042626 ATPase-coupled transmembrane transporter activity 2/83 109/18367 0.0871510600522701 0.29918256435883 SLC26A2/ATP2B1 2 GO:0047485 protein N-terminus binding 2/83 110/18367 0.0885135338921148 0.29918256435883 RPS21/PARP1 2 GO:0015662 P-type ion transporter activity 1/83 21/18367 0.0907775274004926 0.29918256435883 ATP2B1 1 GO:0140358 P-type transmembrane transporter activity 1/83 21/18367 0.0907775274004926 0.29918256435883 ATP2B1 1 GO:0015106 bicarbonate transmembrane transporter activity 1/83 22/18367 0.0948909834795155 0.29918256435883 SLC26A2 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/83 22/18367 0.0948909834795155 0.29918256435883 PRG2 1 GO:0070034 telomerase RNA binding 1/83 22/18367 0.0948909834795155 0.29918256435883 DHX36 1 GO:0003950 NAD+ ADP-ribosyltransferase activity 1/83 23/18367 0.0989860528919549 0.29918256435883 PARP1 1 GO:0005158 insulin receptor binding 1/83 23/18367 0.0989860528919549 0.29918256435883 IGF2 1 GO:0017134 fibroblast growth factor binding 1/83 23/18367 0.0989860528919549 0.29918256435883 ITGAV 1 GO:0030215 semaphorin receptor binding 1/83 23/18367 0.0989860528919549 0.29918256435883 SEMA6A 1 GO:0050750 low-density lipoprotein particle receptor binding 1/83 23/18367 0.0989860528919549 0.29918256435883 LRPAP1 1 GO:0016769 transferase activity, transferring nitrogenous groups 1/83 24/18367 0.10306281682621 0.300122867050288 GAPDH 1 GO:0005112 Notch binding 1/83 25/18367 0.107121356116589 0.300122867050288 AAK1 1 GO:0005160 transforming growth factor beta receptor binding 1/83 25/18367 0.107121356116589 0.300122867050288 ENG 1 GO:0005227 calcium activated cation channel activity 1/83 25/18367 0.107121356116589 0.300122867050288 KCNN4 1 GO:0030247 polysaccharide binding 1/83 25/18367 0.107121356116589 0.300122867050288 AGL 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/83 25/18367 0.107121356116589 0.300122867050288 DHX36 1 GO:0033218 amide binding 4/83 400/18367 0.107352874287683 0.300122867050288 LRPAP1/EBI3/HLA-C/SLC40A1 4 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/83 124/18367 0.108222743880587 0.300122867050288 LDHA/LDHB 2 GO:0008198 ferrous iron binding 1/83 26/18367 0.111161751244837 0.300820564562177 EGLN3 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/83 26/18367 0.111161751244837 0.300820564562177 SLC26A2 1 GO:0042826 histone deacetylase binding 2/83 127/18367 0.112588054109324 0.300820564562177 PARP1/DHX36 2 GO:0016405 CoA-ligase activity 1/83 27/18367 0.115184082341651 0.300820564562177 ACSS1 1 GO:0045499 chemorepellent activity 1/83 27/18367 0.115184082341651 0.300820564562177 SEMA6A 1 GO:0051393 alpha-actinin binding 1/83 27/18367 0.115184082341651 0.300820564562177 PDLIM1 1 GO:0043236 laminin binding 1/83 28/18367 0.119188429188197 0.305349404301191 TINAGL1 1 GO:0070325 lipoprotein particle receptor binding 1/83 28/18367 0.119188429188197 0.305349404301191 LRPAP1 1 GO:0015301 anion:anion antiporter activity 1/83 29/18367 0.123174871217609 0.309336684090412 SLC26A2 1 GO:0002020 protease binding 2/83 135/18367 0.12444586829634 0.309336684090412 ADAMTSL4/ITGAV 2 GO:0015085 calcium ion transmembrane transporter activity 2/83 135/18367 0.12444586829634 0.309336684090412 ITGAV/ATP2B1 2 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/83 136/18367 0.125948983674945 0.309336684090412 LDHA/LDHB 2 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/83 30/18367 0.127143487516493 0.309336684090412 SLC26A2 1 GO:0046873 metal ion transmembrane transporter activity 4/83 430/18367 0.130126316665037 0.309336684090412 KCNN4/ITGAV/ATP2B1/SLC40A1 4 GO:0000146 microfilament motor activity 1/83 31/18367 0.13109435682642 0.309336684090412 MYH10 1 GO:0005164 tumor necrosis factor receptor binding 1/83 31/18367 0.13109435682642 0.309336684090412 TNFSF10 1 GO:0016878 acid-thiol ligase activity 1/83 31/18367 0.13109435682642 0.309336684090412 ACSS1 1 GO:0001223 transcription coactivator binding 1/83 32/18367 0.13502755754541 0.310447974185601 TFAM 1 GO:0030515 snoRNA binding 1/83 32/18367 0.13502755754541 0.310447974185601 PRKDC 1 GO:0048019 receptor antagonist activity 1/83 32/18367 0.13502755754541 0.310447974185601 LRPAP1 1 GO:0140375 immune receptor activity 2/83 144/18367 0.13812679003695 0.311464267660105 CSF3R/EBI3 2 GO:0019956 chemokine binding 1/83 33/18367 0.138943167729415 0.311464267660105 ITGAV 1 GO:0140323 solute:anion antiporter activity 1/83 33/18367 0.138943167729415 0.311464267660105 SLC26A2 1 GO:0019903 protein phosphatase binding 2/83 150/18367 0.147424489120406 0.321487515974696 KCNN4/MET 2 GO:0005506 iron ion binding 2/83 151/18367 0.1489866678298 0.321487515974696 CYP11A1/EGLN3 2 GO:0015103 inorganic anion transmembrane transporter activity 2/83 152/18367 0.150552268307447 0.321487515974696 SLC26A2/CLIC3 2 GO:0042605 peptide antigen binding 1/83 36/18367 0.150585230530898 0.321487515974696 HLA-C 1 GO:0042805 actinin binding 1/83 36/18367 0.150585230530898 0.321487515974696 PDLIM1 1 GO:0097718 disordered domain specific binding 1/83 36/18367 0.150585230530898 0.321487515974696 GAPDH 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/83 37/18367 0.154431252344544 0.322031061090561 GAPDH 1 GO:0043531 ADP binding 1/83 37/18367 0.154431252344544 0.322031061090561 MYH10 1 GO:0046915 transition metal ion transmembrane transporter activity 1/83 37/18367 0.154431252344544 0.322031061090561 SLC40A1 1 GO:0008395 steroid hydroxylase activity 1/83 38/18367 0.15826006882329 0.32747660394973 CYP11A1 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/83 39/18367 0.162071756001404 0.332803834842578 IQGAP2 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/83 310/18367 0.165130675510355 0.333096701368407 JUN/ASCL2/PEG3 3 GO:0017080 sodium channel regulator activity 1/83 40/18367 0.165866389581276 0.333096701368407 FXYD5 1 GO:0001217 DNA-binding transcription repressor activity 3/83 313/18367 0.168431922984968 0.333096701368407 JUN/ASCL2/PEG3 3 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/83 41/18367 0.169644044934839 0.333096701368407 ACSS1 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/83 41/18367 0.169644044934839 0.333096701368407 COL14A1 1 GO:0030331 estrogen receptor binding 1/83 41/18367 0.169644044934839 0.333096701368407 PARP1 1 GO:0008307 structural constituent of muscle 1/83 42/18367 0.173404797105002 0.338013698704678 KRT19 1 GO:0016504 peptidase activator activity 1/83 43/18367 0.177148720807064 0.340249052627303 APP 1 GO:0030547 signaling receptor inhibitor activity 1/83 43/18367 0.177148720807064 0.340249052627303 LRPAP1 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2/83 170/18367 0.179250114211767 0.340249052627303 CYP11A1/EGLN3 2 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/83 44/18367 0.180875890430127 0.340249052627303 GAPDH 1 GO:0022839 ion gated channel activity 1/83 44/18367 0.180875890430127 0.340249052627303 KCNN4 1 GO:0005245 voltage-gated calcium channel activity 1/83 45/18367 0.184586380038505 0.344817612710819 ITGAV 1 GO:0019829 ATPase-coupled cation transmembrane transporter activity 1/83 47/18367 0.191957613852898 0.35264308709619 ATP2B1 1 GO:0070888 E-box binding 1/83 48/18367 0.195618504576163 0.35264308709619 ASCL2 1 GO:0015399 primary active transmembrane transporter activity 2/83 181/18367 0.197180256038162 0.35264308709619 SLC26A2/ATP2B1 2 GO:0022836 gated channel activity 3/83 340/18367 0.198963408023614 0.35264308709619 CLIC3/KCNN4/ITGAV 3 GO:0016763 pentosyltransferase activity 1/83 49/18367 0.19926300832201 0.35264308709619 PARP1 1 GO:0032813 tumor necrosis factor receptor superfamily binding 1/83 49/18367 0.19926300832201 0.35264308709619 TNFSF10 1 GO:0043539 protein serine/threonine kinase activator activity 1/83 49/18367 0.19926300832201 0.35264308709619 IGF2 1 GO:0098632 cell-cell adhesion mediator activity 1/83 49/18367 0.19926300832201 0.35264308709619 PDLIM1 1 GO:0016830 carbon-carbon lyase activity 1/83 52/18367 0.210098920726528 0.364623288228619 ALDOA 1 GO:0031593 polyubiquitin modification-dependent protein binding 1/83 52/18367 0.210098920726528 0.364623288228619 AGL 1 GO:1901682 sulfur compound transmembrane transporter activity 1/83 52/18367 0.210098920726528 0.364623288228619 SLC26A2 1 GO:0050661 NADP binding 1/83 53/18367 0.213678598017256 0.368458608119499 GAPDH 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/83 54/18367 0.217242247485672 0.372217608749337 EGLN3 1 GO:0005080 protein kinase C binding 1/83 55/18367 0.220789940024234 0.37317568286931 ITGAV 1 GO:0016829 lyase activity 2/83 196/18367 0.22196323144643 0.37317568286931 ALDOA/APMAP 2 GO:0019902 phosphatase binding 2/83 196/18367 0.22196323144643 0.37317568286931 KCNN4/MET 2 GO:0005244 voltage-gated ion channel activity 2/83 201/18367 0.230285492131717 0.382387638169333 CLIC3/ITGAV 2 GO:0022832 voltage-gated channel activity 2/83 201/18367 0.230285492131717 0.382387638169333 CLIC3/ITGAV 2 GO:0098631 cell adhesion mediator activity 1/83 59/18367 0.234822547917328 0.387529235520007 PDLIM1 1 GO:0005507 copper ion binding 1/83 61/18367 0.241744930850913 0.396520648773754 F5 1 GO:0004674 protein serine/threonine kinase activity 3/83 386/18367 0.253614591333982 0.413468636780855 PRKDC/AAK1/ENG 3 GO:0097110 scaffold protein binding 1/83 67/18367 0.262142996044639 0.424797987566313 KRT8 1 GO:0000287 magnesium ion binding 2/83 221/18367 0.263741185364449 0.424828615946328 S100P/DHX36 2 GO:0003678 DNA helicase activity 1/83 72/18367 0.278726517661239 0.446294245540913 DHX36 1 GO:0003725 double-stranded RNA binding 1/83 74/18367 0.285256337798713 0.451376205105023 DHX36 1 GO:0005254 chloride channel activity 1/83 74/18367 0.285256337798713 0.451376205105023 CLIC3 1 GO:0005125 cytokine activity 2/83 235/18367 0.28720320070388 0.451799187072186 TNFSF10/EBI3 2 GO:0001618 virus receptor activity 1/83 76/18367 0.291727748147868 0.455973105137552 ITGAV 1 GO:0003724 RNA helicase activity 1/83 77/18367 0.294941711129866 0.455973105137552 DHX36 1 GO:0140272 exogenous protein binding 1/83 77/18367 0.294941711129866 0.455973105137552 ITGAV 1 GO:0001221 transcription coregulator binding 1/83 78/18367 0.298141264873782 0.458285715720271 TFAM 1 GO:0008186 ATP-dependent activity, acting on RNA 1/83 79/18367 0.301326473196571 0.460550120965213 DHX36 1 GO:0005216 ion channel activity 3/83 432/18367 0.310174564264663 0.471395241735561 CLIC3/KCNN4/ITGAV 3 GO:0001540 amyloid-beta binding 1/83 84/18367 0.317039547612906 0.476444906747887 LRPAP1 1 GO:0030165 PDZ domain binding 1/83 84/18367 0.317039547612906 0.476444906747887 ATP2B1 1 GO:0005253 anion channel activity 1/83 87/18367 0.326299271083438 0.485959318380802 CLIC3 1 GO:0048306 calcium-dependent protein binding 1/83 88/18367 0.329358196712545 0.485959318380802 S100P 1 GO:0003713 transcription coactivator activity 2/83 262/18367 0.33218710126367 0.485959318380802 PDLIM1/PAGE4 2 GO:0008081 phosphoric diester hydrolase activity 1/83 89/18367 0.332403399933337 0.485959318380802 SMPDL3A 1 GO:0015297 antiporter activity 1/83 89/18367 0.332403399933337 0.485959318380802 SLC26A2 1 GO:0022853 active ion transmembrane transporter activity 2/83 267/18367 0.340445128796294 0.4936475100996 SLC26A2/ATP2B1 2 GO:0051213 dioxygenase activity 1/83 92/18367 0.341457281932441 0.4936475100996 EGLN3 1 GO:0016757 glycosyltransferase activity 2/83 270/18367 0.345385632857867 0.4936475100996 AGL/PARP1 2 GO:0005126 cytokine receptor binding 2/83 271/18367 0.347029946374091 0.4936475100996 TNFSF10/ENG 2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/83 94/18367 0.347425699027723 0.4936475100996 AGL 1 GO:0016887 ATP hydrolysis activity 2/83 272/18367 0.348672962523881 0.4936475100996 ATP2B1/DHX36 2 GO:0030295 protein kinase activator activity 1/83 101/18367 0.36789736201446 0.514296875918184 IGF2 1 GO:0015267 channel activity 3/83 480/18367 0.369670879592022 0.514296875918184 CLIC3/KCNN4/ITGAV 3 GO:0004497 monooxygenase activity 1/83 102/18367 0.370769612039249 0.514296875918184 CYP11A1 1 GO:0022803 passive transmembrane transporter activity 3/83 481/18367 0.370905553636163 0.514296875918184 CLIC3/KCNN4/ITGAV 3 GO:0003712 transcription coregulator activity 3/83 489/18367 0.380767990090761 0.525264560689306 PDLIM1/BTG1/PAGE4 3 GO:0019209 kinase activator activity 1/83 107/18367 0.38493857936887 0.528308560460337 IGF2 1 GO:0031625 ubiquitin protein ligase binding 2/83 297/18367 0.389266843872063 0.531536959398908 JUN/ISG15 2 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 2/83 299/18367 0.3924695646837 0.532682413491616 JUN/PARP1 2 GO:0004222 metalloendopeptidase activity 1/83 111/18367 0.396046404082986 0.532682413491616 PAPPA2 1 GO:0008094 ATP-dependent activity, acting on DNA 1/83 111/18367 0.396046404082986 0.532682413491616 DHX36 1 GO:0003774 cytoskeletal motor activity 1/83 114/18367 0.404246991816062 0.541007168151845 MYH10 1 GO:0008509 anion transmembrane transporter activity 2/83 314/18367 0.41624824285269 0.55301243298108 SLC26A2/CLIC3 2 GO:0005262 calcium channel activity 1/83 119/18367 0.417670857968912 0.55301243298108 ITGAV 1 GO:0044389 ubiquitin-like protein ligase binding 2/83 316/18367 0.419384893413161 0.55301243298108 JUN/ISG15 2 GO:0005267 potassium channel activity 1/83 121/18367 0.422956337637252 0.555001243045955 KCNN4 1 GO:0005179 hormone activity 1/83 122/18367 0.425581275923787 0.555734772929605 IGF2 1 GO:0003697 single-stranded DNA binding 1/83 123/18367 0.428194416734876 0.556445884549187 DHX36 1 GO:0031072 heat shock protein binding 1/83 129/18367 0.443628431796762 0.573731000737158 TFAM 1 GO:0005261 cation channel activity 2/83 335/18367 0.448753913616373 0.577582788338777 KCNN4/ITGAV 2 GO:0003924 GTPase activity 2/83 337/18367 0.451798298023658 0.578398922402974 TUBB2A/ARL4A 2 GO:0044325 transmembrane transporter binding 1/83 133/18367 0.453688374078169 0.578398922402974 TCAF1 1 GO:0043177 organic acid binding 1/83 135/18367 0.458650741256296 0.581967214141244 EGLN3 1 GO:0020037 heme binding 1/83 139/18367 0.468442259588059 0.588836298267233 CYP11A1 1 GO:0099106 ion channel regulator activity 1/83 139/18367 0.468442259588059 0.588836298267233 FXYD5 1 GO:0070851 growth factor receptor binding 1/83 141/18367 0.473272197054269 0.590713541146499 APP 1 GO:0022843 voltage-gated cation channel activity 1/83 143/18367 0.478058771861675 0.590713541146499 ITGAV 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 1/83 144/18367 0.480435918587722 0.590713541146499 AGL 1 GO:0016922 nuclear receptor binding 1/83 144/18367 0.480435918587722 0.590713541146499 PARP1 1 GO:0016247 channel regulator activity 1/83 145/18367 0.482802368610068 0.590713541146499 FXYD5 1 GO:0106310 protein serine kinase activity 2/83 360/18367 0.486120728291094 0.590713541146499 PRKDC/AAK1 2 GO:0008528 G protein-coupled peptide receptor activity 1/83 147/18367 0.487503368529824 0.590713541146499 LGR5 1 GO:0052689 carboxylic ester hydrolase activity 1/83 147/18367 0.487503368529824 0.590713541146499 APMAP 1 GO:0019842 vitamin binding 1/83 148/18367 0.48983801289931 0.590880831703651 EGLN3 1 GO:0046906 tetrapyrrole binding 1/83 149/18367 0.492162149511053 0.591034009903899 CYP11A1 1 GO:0001653 peptide receptor activity 1/83 153/18367 0.501354549690235 0.599397217185214 LGR5 1 GO:0015079 potassium ion transmembrane transporter activity 1/83 155/18367 0.505888908225994 0.599516981437585 KCNN4 1 GO:0015631 tubulin binding 2/83 375/18367 0.507791212922506 0.599516981437585 ALDOA/GAPDH 2 GO:0004386 helicase activity 1/83 156/18367 0.508140787240778 0.599516981437585 DHX36 1 GO:0005525 GTP binding 2/83 377/18367 0.510636431030867 0.599830567455472 TUBB2A/ARL4A 2 GO:0140030 modification-dependent protein binding 1/83 160/18367 0.517047356333174 0.604720603711408 AGL 1 GO:0008083 growth factor activity 1/83 162/18367 0.521440699295139 0.606924677623803 IGF2 1 GO:0046943 carboxylic acid transmembrane transporter activity 1/83 163/18367 0.523622540655123 0.606924677623803 SLC26A2 1 GO:0005342 organic acid transmembrane transporter activity 1/83 164/18367 0.525794553900872 0.606924677623803 SLC26A2 1 GO:0016874 ligase activity 1/83 165/18367 0.527956782765687 0.606924677623803 ACSS1 1 GO:0140297 DNA-binding transcription factor binding 2/83 394/18367 0.534390932641512 0.61115795082198 JUN/PARP1 2 GO:0019001 guanyl nucleotide binding 2/83 398/18367 0.539866957163202 0.61115795082198 TUBB2A/ARL4A 2 GO:0032561 guanyl ribonucleotide binding 2/83 398/18367 0.539866957163202 0.61115795082198 TUBB2A/ARL4A 2 GO:0003823 antigen binding 1/83 171/18367 0.540727108905692 0.61115795082198 HLA-C 1 GO:1901981 phosphatidylinositol phosphate binding 1/83 173/18367 0.544907560919968 0.612595087367327 IQGAP2 1 GO:0004252 serine-type endopeptidase activity 1/83 174/18367 0.546983666913353 0.612595087367327 HTRA1 1 GO:0022804 active transmembrane transporter activity 2/83 406/18367 0.550687750685128 0.612595087367327 SLC26A2/ATP2B1 2 GO:0031406 carboxylic acid binding 1/83 176/18367 0.551107848114844 0.612595087367327 EGLN3 1 GO:0008514 organic anion transmembrane transporter activity 1/83 185/18367 0.569212315015231 0.630115690284351 SLC26A2 1 GO:0008237 metallopeptidase activity 1/83 190/18367 0.578956645583545 0.636510121119399 PAPPA2 1 GO:0008236 serine-type peptidase activity 1/83 191/18367 0.580879217978141 0.636510121119399 HTRA1 1 GO:0004175 endopeptidase activity 2/83 430/18367 0.582087322659376 0.636510121119399 HTRA1/PAPPA2 2 GO:0017171 serine hydrolase activity 1/83 195/18367 0.588483157488853 0.640898661394743 HTRA1 1 GO:0016758 hexosyltransferase activity 1/83 197/18367 0.592233854222673 0.642382688652819 AGL 1 GO:0003730 mRNA 3'-UTR binding 1/83 201/18367 0.599634217496763 0.647797608460359 DHX36 1 GO:0019887 protein kinase regulator activity 1/83 204/18367 0.605097265264113 0.650554217702673 IGF2 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 2/83 450/18367 0.607022708711416 0.650554217702673 JUN/PBX1 2 GO:0001216 DNA-binding transcription activator activity 2/83 456/18367 0.61428415278628 0.655723956744084 JUN/PBX1 2 GO:0005096 GTPase activator activity 2/83 462/18367 0.62144448181747 0.66074531861225 JUN/IQGAP2 2 GO:0140097 catalytic activity, acting on DNA 1/83 229/18367 0.647849539191232 0.684382966350278 DHX36 1 GO:0030695 GTPase regulator activity 2/83 488/18367 0.651308696601008 0.684382966350278 JUN/IQGAP2 2 GO:0060589 nucleoside-triphosphatase regulator activity 2/83 488/18367 0.651308696601008 0.684382966350278 JUN/IQGAP2 2 GO:0019207 kinase regulator activity 1/83 233/18367 0.654251757398598 0.684800477588416 IGF2 1 GO:0015291 secondary active transmembrane transporter activity 1/83 240/18367 0.66518010801417 0.693540500216324 SLC26A2 1 GO:0031267 small GTPase binding 1/83 259/18367 0.693152079945348 0.719914708514667 IQGAP2 1 GO:0008017 microtubule binding 1/83 271/18367 0.709615559137504 0.731366227616815 GAPDH 1 GO:0035091 phosphatidylinositol binding 1/83 271/18367 0.709615559137504 0.731366227616815 IQGAP2 1 GO:0051020 GTPase binding 1/83 291/18367 0.735136846684856 0.754777907474146 IQGAP2 1 GO:0001664 G protein-coupled receptor binding 1/83 295/18367 0.739968555018974 0.755199986344096 WLS 1 GO:0030674 protein-macromolecule adaptor activity 1/83 296/18367 0.741162811876733 0.755199986344096 COL14A1 1 GO:0046982 protein heterodimerization activity 1/83 328/18367 0.776645975182505 0.788368933298467 TENM3 1 GO:0042578 phosphoric ester hydrolase activity 1/83 366/18367 0.812583988925828 0.821270742924994 SMPDL3A 1 GO:0060090 molecular adaptor activity 1/83 369/18367 0.815164640747113 0.821270742924994 COL14A1 1 GO:0140098 catalytic activity, acting on RNA 1/83 386/18367 0.829138801679412 0.832232603178216 DHX36 1 GO:0005543 phospholipid binding 1/83 466/18367 0.882092488240738 0.882092488240738 IQGAP2 1