ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003779	actin binding	34/321	440/18367	3.85149109017406e-13	2.33785509173565e-10	TMSB4X/ALDOA/FXYD5/AIF1/GMFG/EPS8L1/LSP1/PDLIM2/FLNA/CORO1A/MARCKS/COTL1/CXCR4/LCP1/MSN/EZR/SYNE1/CAPG/FLNB/TPM4/PFN1/ITGB1/IQGAP2/MYH9/PLEC/GBP1/MYH10/ANXA6/CAPZA1/S100A4/CAPZB/DST/VASP/ACTR3	34
GO:0045296	cadherin binding	27/321	332/18367	3.59074669862233e-11	1.08979162303188e-08	LDHA/ALDOA/FXYD5/EFHD2/EPS8L1/FLNA/PKM/EZR/ANXA1/CAPG/ENO1/FLNB/KRT18/S100P/EIF4H/PFN1/ITGB1/MYH9/TAGLN2/PLEC/STAT1/CAPZA1/CAPZB/VASP/HSPA1A/IDH1/CTNNB1	27
GO:0042605	peptide antigen binding	9/321	36/18367	8.4570587332258e-09	1.71114488368935e-06	HLA-A/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-E/HLA-C/DHCR24	9
GO:0023026	MHC class II protein complex binding	8/321	27/18367	1.32661309723794e-08	2.01313537505857e-06	HLA-DMA/PKM/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/CD74/B2M	8
GO:0051015	actin filament binding	18/321	217/18367	5.36118701458413e-08	6.50848103570514e-06	AIF1/FLNA/CORO1A/MARCKS/COTL1/LCP1/EZR/SYNE1/CAPG/FLNB/TPM4/IQGAP2/MYH9/MYH10/ANXA6/CAPZA1/CAPZB/ACTR3	18
GO:0023023	MHC protein complex binding	8/321	36/18367	1.57677507240396e-07	1.59517078158201e-05	HLA-DMA/PKM/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/CD74/B2M	8
GO:0001968	fibronectin binding	7/321	28/18367	4.02983263512912e-07	3.4944405850334e-05	CTSS/PLEKHA2/CCDC80/FBLN1/ITGB1/IGFBP3/CTSL	7
GO:0042608	T cell receptor binding	5/321	11/18367	6.69906420971596e-07	5.08291496912199e-05	HLA-A/EPS8L1/HLA-DRB1/HLA-DRA/HLA-E	5
GO:0005178	integrin binding	13/321	144/18367	1.50587023826981e-06	0.000101562581625531	IGF2/ITGB2/FN1/LCP1/ISG15/TIMP2/FBLN1/FBN1/HMGB1/ITGB1/MYH9/DST/PLPP3	13
GO:0005200	structural constituent of cytoskeleton	11/321	103/18367	1.86895901978418e-06	0.0001134458125009	KRT19/VIM/HLA-DRB1/MSN/ACTG1/DSP/PLEC/TUBB6/TUBB/ACTR3/ACTB	11
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/321	10/18367	1.76967282253537e-05	0.000976537639344516	NCF2/CYBB/NCF1/CYBA	4
GO:0097718	disordered domain specific binding	6/321	36/18367	3.40441099390682e-05	0.00172206456108453	GAPDH/FN1/EZR/HSPA1A/CTNNB1/GJA1	6
GO:0044389	ubiquitin-like protein ligase binding	17/321	316/18367	4.42347169811512e-05	0.00206542101596606	TXNIP/TNFRSF1B/LAPTM5/CXCR4/ISG15/TPI1/NEK6/RPL23/ACTG1/JUN/STAT1/PA2G4/UBE2J1/PSMD1/TUBB/HSPA1A/CEBPB	17
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	4/321	15/18367	0.000107334929388116	0.00465373586704188	NCF2/CYBB/NCF1/CYBA	4
GO:0002020	protease binding	10/321	135/18367	0.00013240259254044	0.00535789157813645	SERPINB9/SERPINA1/FN1/TIMP2/TIMP3/ADAMTSL4/SRI/ITGB1/PSAP/CARD16	10
GO:0048306	calcium-dependent protein binding	8/321	88/18367	0.000152421627854875	0.00578249550674433	S100A6/ANXA4/ANXA1/S100P/ANXA6/S100A4/S100A9/PDCD6	8
GO:0019955	cytokine binding	10/321	139/18367	0.000168447768374901	0.00601457620020972	TNFRSF1B/CXCR4/NRP2/ZFP36/HMGB1/ITGB1/TGFBR1/CD74/GBP1/CSF2RA	10
GO:0140297	DNA-binding transcription factor binding	18/321	394/18367	0.000211575765668328	0.00695776143160368	NEK6/ANXA4/FUS/MTDH/BHLHE40/ISL1/HMGB1/SRI/HMGN3/JUN/PARP1/STAT1/BHLHE41/ACTB/GMNN/HSPB1/CTNNB1/CEBPB	18
GO:0004857	enzyme inhibitor activity	7/321	70/18367	0.000217788249094679	0.00695776143160368	TXNIP/RPL23/ANXA4/RPL37/ANXA1/DYNLL1/OAZ1	7
GO:0031625	ubiquitin protein ligase binding	15/321	297/18367	0.000246016499194955	0.00746660075056687	TXNIP/TNFRSF1B/LAPTM5/CXCR4/ISG15/TPI1/NEK6/RPL23/ACTG1/JUN/PA2G4/UBE2J1/PSMD1/TUBB/HSPA1A	15
GO:0043394	proteoglycan binding	5/321	36/18367	0.000381905975527395	0.0105833290732197	PTPRC/CTSS/FN1/CTSB/CTSL	5
GO:0005080	protein kinase C binding	6/321	55/18367	0.000383580295899232	0.0105833290732197	PLEK/FLNA/MARCKS/DSP/HSPB1/TOP2A	6
GO:0140678	molecular function inhibitor activity	9/321	128/18367	0.000420123444151897	0.0110876056782696	TXNIP/CAV1/RPL23/ANXA4/RPL37/ANXA1/DYNLL1/OAZ1/ID1	9
GO:0032395	MHC class II receptor activity	3/321	10/18367	0.00057935237577799	0.0140666756838896	HLA-DPA1/HLA-DRB1/HLA-DRA	3
GO:0050786	RAGE receptor binding	3/321	10/18367	0.00057935237577799	0.0140666756838896	HMGB1/S100A4/S100A9	3
GO:0061134	peptidase regulator activity	12/321	230/18367	0.00076107684898581	0.0164585881322511	GAPDH/SERPINB9/SERPINA1/BST2/FN1/CAV1/TIMP2/FBLN1/SERPINB1/TIMP3/TFPI2/CARD16	12
GO:0016209	antioxidant activity	7/321	86/18367	0.00076981226710436	0.0164585881322511	GPX3/GPX1/SOD2/GSTO1/GPX4/S100A9/SOD3	7
GO:0005536	glucose binding	3/321	11/18367	0.000786324638937859	0.0164585881322511	SLC2A3/PYGL/UGP2	3
GO:0019864	IgG binding	3/321	11/18367	0.000786324638937859	0.0164585881322511	FCGR3A/FCGR2A/FCER1G	3
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	14/321	299/18367	0.000829522070247843	0.0167839965546814	ANXA4/FUS/MTDH/BHLHE40/ISL1/HMGN3/JUN/PARP1/STAT1/BHLHE41/ACTB/HSPB1/CTNNB1/CEBPB	14
GO:0003823	antigen binding	10/321	171/18367	0.000873703260209484	0.0171076735144244	HLA-A/HLA-B/FCN1/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-E/HLA-C/DHCR24	10
GO:0097110	scaffold protein binding	6/321	67/18367	0.00110853039377289	0.0210274359068795	VIM/KRT8/DSP/DYNLL1/KRT18/PSAP	6
GO:0005518	collagen binding	6/321	69/18367	0.00129342005298721	0.0237910900655526	CTSS/FN1/COL14A1/ITGB1/CTSB/CTSL	6
GO:0003735	structural constituent of ribosome	10/321	182/18367	0.00140122405131045	0.0250159705631012	RPS29/RPL37A/RPS27/RPS21/ISG15/RPS17/RPL23/RPL36/RPS28/RPL37	10
GO:0008022	protein C-terminus binding	10/321	189/18367	0.0018547357225613	0.0313401410643679	NCF2/CORO1A/FN1/EZR/FBLN1/MKI67/DST/ID1/CTNNB1/TOP2A	10
GO:0003725	double-stranded RNA binding	6/321	74/18367	0.00185872335801853	0.0313401410643679	VIM/MSN/MTDH/EIF4H/HMGB1/TFRC	6
GO:0005164	tumor necrosis factor receptor binding	4/321	31/18367	0.00198519771462867	0.0320426107033954	TNFSF10/TNFSF13B/SIVA1/STAT1	4
GO:0017124	SH3 domain binding	8/321	130/18367	0.00205089585962855	0.0320426107033954	SH3BGRL/NCF1/CYBA/GPX1/ADAM12/VASP/LRP2/GJA1	8
GO:0050998	nitric-oxide synthase binding	3/321	15/18367	0.00205875093481453	0.0320426107033954	CAV1/CD74/ACTB	3
GO:0001618	virus receptor activity	6/321	76/18367	0.00213077973872238	0.0323345825351122	CXCR4/ITGB1/SIVA1/CDK1/HSPA1A/TFRC	6
GO:0140272	exogenous protein binding	6/321	77/18367	0.00227757253647336	0.0337191836497397	CXCR4/ITGB1/SIVA1/CDK1/HSPA1A/TFRC	6
GO:0008191	metalloendopeptidase inhibitor activity	3/321	16/18367	0.00250127452782297	0.0354602036274433	BST2/TIMP2/TIMP3	3
GO:0019956	chemokine binding	4/321	33/18367	0.00251200783522251	0.0354602036274433	CXCR4/ZFP36/HMGB1/ITGB1	4
GO:0020037	heme binding	8/321	139/18367	0.00310801725601235	0.0428765107818067	CYP2J2/CYBB/CYBA/CYP11A1/CYP19A1/BACH1/STC2/HMOX1	8
GO:0008047	enzyme activator activity	7/321	110/18367	0.00319864609457025	0.0431461817645364	NCF2/GMFG/NCF1/CCL3/PSAP/AZIN1/DBF4	7
GO:0008301	DNA binding, bending	3/321	18/18367	0.00355173214549779	0.0468674220068948	HMGB3/HMGB1/TOP2A	3
GO:0098631	cell adhesion mediator activity	5/321	59/18367	0.00365836413332159	0.0472473835941746	ANXA1/DSP/KRT18/ITGB1/EMB	5
GO:0140375	immune receptor activity	8/321	144/18367	0.00385535797508536	0.0487542143932669	HLA-DPA1/CXCR4/FCER1G/HLA-DRB1/HLA-DRA/IFNGR2/CD74/CSF2RA	8
GO:0016651	oxidoreductase activity, acting on NAD(P)H	6/321	88/18367	0.00443971740784634	0.0544353449050073	NCF2/CYBB/NCF1/CYBA/NDUFB1/NDUFB7	6
GO:0004866	endopeptidase inhibitor activity	9/321	180/18367	0.00448396580766123	0.0544353449050073	GAPDH/SERPINB9/SERPINA1/BST2/TIMP2/SERPINB1/TIMP3/TFPI2/CARD16	9
GO:0046906	tetrapyrrole binding	8/321	149/18367	0.00473453947962427	0.0563503032182732	CYP2J2/CYBB/CYBA/CYP11A1/CYP19A1/BACH1/STC2/HMOX1	8
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/321	20/18367	0.00483561311110019	0.0564464838161118	STAT1/EZH2/CEBPB	3
GO:0031492	nucleosomal DNA binding	4/321	40/18367	0.00509895002390083	0.0583974087642982	MBD3/HMGN2/HMGN3/ACTB	4
GO:0030331	estrogen receptor binding	4/321	41/18367	0.00557376288213099	0.0626532235083983	FUS/ISL1/PARP1/CTNNB1	4
GO:0030414	peptidase inhibitor activity	9/321	187/18367	0.00573454329159312	0.0632885050544914	GAPDH/SERPINB9/SERPINA1/BST2/TIMP2/SERPINB1/TIMP3/TFPI2/CARD16	9
GO:0004602	glutathione peroxidase activity	3/321	22/18367	0.00636625636055006	0.0690056716223909	GPX3/GPX1/GPX4	3
GO:0009055	electron transfer activity	7/321	126/18367	0.00670982027340349	0.0714537001044898	NCF2/CYBB/NCF1/CYBA/CYP19A1/NDUFB1/NDUFB7	7
GO:0019865	immunoglobulin binding	3/321	23/18367	0.0072276627264801	0.0744751044533642	FCGR3A/FCGR2A/FCER1G	3
GO:0061135	endopeptidase regulator activity	9/321	194/18367	0.00723893107536819	0.0744751044533642	GAPDH/SERPINB9/SERPINA1/BST2/TIMP2/SERPINB1/TIMP3/TFPI2/CARD16	9
GO:0048029	monosaccharide binding	5/321	71/18367	0.00803408183460022	0.0811464748424416	ALDOA/SLC2A3/P4HA1/PYGL/UGP2	5
GO:0043495	protein-membrane adaptor activity	3/321	24/18367	0.00815475282601143	0.0811464748424416	SYNE1/MYH9/PDCD6	3
GO:0030246	carbohydrate binding	11/321	271/18367	0.00838254043968036	0.0820677749497738	ALDOA/VCAN/FCN1/SLC2A3/P4HA1/HLA-DRB1/HLA-DRA/SIGLEC6/PYGL/GALNT11/UGP2	11
GO:0044325	transmembrane transporter binding	7/321	133/18367	0.00892344654715199	0.085976699271766	TSPO/FLNA/CAV1/SRI/TCAF1/PDE4B/CTNNB1	7
GO:0016763	pentosyltransferase activity	4/321	49/18367	0.0104608832402592	0.0962084261642017	UPP1/PARP14/NAMPT/PARP1	4
GO:0032813	tumor necrosis factor receptor superfamily binding	4/321	49/18367	0.0104608832402592	0.0962084261642017	TNFSF10/TNFSF13B/SIVA1/STAT1	4
GO:0098632	cell-cell adhesion mediator activity	4/321	49/18367	0.0104608832402592	0.0962084261642017	ANXA1/DSP/KRT18/EMB	4
GO:0015485	cholesterol binding	4/321	50/18367	0.0112175970722439	0.101227706949975	TSPO/CAV1/ANXA6/NPC2	4
GO:0043425	bHLH transcription factor binding	3/321	27/18367	0.0113401714540334	0.101227706949975	BHLHE40/ISL1/BHLHE41	3
GO:0001221	transcription coregulator binding	5/321	78/18367	0.011808502590345	0.102857507178909	NEK6/RPL23/STAT1/EZH2/CTNNB1	5
GO:0046332	SMAD binding	5/321	79/18367	0.0124311131275154	0.102857507178909	FLNA/TGFBR1/JUN/PARP1/CTNNB1	5
GO:0005522	profilin binding	2/321	10/18367	0.0124896653376142	0.102857507178909	ACTG1/VASP	2
GO:0016176	superoxide-generating NADPH oxidase activator activity	2/321	10/18367	0.0124896653376142	0.102857507178909	NCF2/NCF1	2
GO:0003785	actin monomer binding	3/321	28/18367	0.0125394654550894	0.102857507178909	TMSB4X/CORO1A/PFN1	3
GO:0043236	laminin binding	3/321	28/18367	0.0125394654550894	0.102857507178909	CTSS/PLEKHA2/ITGB1	3
GO:0016922	nuclear receptor binding	7/321	144/18367	0.013421489282037	0.108624586589286	FUS/ISL1/HMGN3/PARP1/STAT1/CTNNB1/CEBPB	7
GO:0005520	insulin-like growth factor binding	3/321	29/18367	0.0138086172866314	0.108854944064744	HTRA1/IGFBP3/LRP2	3
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	3/321	29/18367	0.0138086172866314	0.108854944064744	PLEK/NCF1/PLEKHA2	3
GO:0099186	structural constituent of postsynapse	2/321	11/18367	0.0150904077150978	0.117434326705954	ACTG1/ACTB	2
GO:0140677	molecular function activator activity	7/321	150/18367	0.0164659984484972	0.125172787401171	NCF2/GMFG/NCF1/CCL3/PSAP/AZIN1/DBF4	7
GO:0051287	NAD binding	4/321	56/18367	0.0164972372192647	0.125172787401171	GAPDH/LDHA/PARP1/IDH1	4
GO:0001222	transcription corepressor binding	3/321	32/18367	0.0180398898531555	0.134914467544365	NEK6/STAT1/EZH2	3
GO:0003727	single-stranded RNA binding	5/321	87/18367	0.0182256776583821	0.134914467544365	HNRNPDL/ANXA1/EIF4H/HMGB1/SSB	5
GO:0005539	glycosaminoglycan binding	9/321	230/18367	0.0201689276114242	0.14750047060403	PTPRC/VCAN/FN1/NRP2/CCDC80/FBN1/PGF/ANXA6/SOD3	9
GO:0032934	sterol binding	4/321	60/18367	0.0207541634901649	0.147620036918848	TSPO/CAV1/ANXA6/NPC2	4
GO:0004859	phospholipase inhibitor activity	2/321	13/18367	0.0209148651977281	0.147620036918848	ANXA4/ANXA1	2
GO:0031994	insulin-like growth factor I binding	2/321	13/18367	0.0209148651977281	0.147620036918848	IGFBP3/LRP2	2
GO:0044548	S100 protein binding	2/321	14/18367	0.0241225981083945	0.161582893816086	EZR/S100A6	2
GO:0070411	I-SMAD binding	2/321	14/18367	0.0241225981083945	0.161582893816086	TGFBR1/CTNNB1	2
GO:0140666	annealing activity	2/321	14/18367	0.0241225981083945	0.161582893816086	ANXA1/EIF4H	2
GO:0042826	histone deacetylase binding	6/321	127/18367	0.0242091844697282	0.161582893816086	PARP1/HSPA1A/BHLHE41/GMNN/TOP2A/CEBPB	6
GO:0033218	amide binding	13/321	400/18367	0.0242241241141085	0.161582893816086	HLA-A/HLA-B/ITGB2/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-E/HLA-C/DBI/CD74/PSAP/DHCR24	13
GO:0042277	peptide binding	11/321	321/18367	0.0261751549195323	0.171246843317414	HLA-A/HLA-B/ITGB2/HLA-DPA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-E/HLA-C/CD74/DHCR24	11
GO:0042056	chemoattractant activity	3/321	37/18367	0.0265192805137346	0.171246843317414	CCL3/PGF/HMGB1	3
GO:0043531	ADP binding	3/321	37/18367	0.0265192805137346	0.171246843317414	MYH9/MYH10/PGK1	3
GO:0008201	heparin binding	7/321	166/18367	0.0269132419054199	0.171961450911472	PTPRC/FN1/NRP2/CCDC80/FBN1/PGF/SOD3	7
GO:0071933	Arp2/3 complex binding	2/321	15/18367	0.0275170361350991	0.173987926395887	GMFG/IQGAP2	2
GO:0008395	steroid hydroxylase activity	3/321	38/18367	0.0284296014008673	0.177904825261097	CYP2J2/CYP11A1/CYP19A1	3
GO:0005521	lamin binding	2/321	16/18367	0.03109071636471	0.190626917508879	SYNE1/BNIP3L	2
GO:1990404	protein ADP-ribosylase activity	2/321	16/18367	0.03109071636471	0.190626917508879	PARP14/PARP1	2
GO:0005201	extracellular matrix structural constituent	7/321	172/18367	0.0317855401707533	0.191313437923721	FGL2/VCAN/FN1/FBLN1/FBN1/COL14A1/TFPI2	7
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	3/321	40/18367	0.0324634005043546	0.191313437923721	CYP2J2/CYP19A1/HMOX1	3
GO:0042287	MHC protein binding	3/321	40/18367	0.0324634005043546	0.191313437923721	HLA-E/CD74/TUBB	3
GO:0044183	protein folding chaperone	3/321	40/18367	0.0324634005043546	0.191313437923721	CD74/HSPA1A/HSPB1	3
GO:0031490	chromatin DNA binding	5/321	103/18367	0.0345789106941724	0.195793348363166	MBD3/HMGN2/HMGN3/EZH2/ACTB	5
GO:0000400	four-way junction DNA binding	2/321	17/18367	0.0348363782919637	0.195793348363166	HMGB3/HMGB1	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/321	17/18367	0.0348363782919637	0.195793348363166	PTPRC/PTPRA	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/321	17/18367	0.0348363782919637	0.195793348363166	PTPRC/PTPRA	2
GO:0043024	ribosomal small subunit binding	2/321	17/18367	0.0348363782919637	0.195793348363166	EIF4H/EIF1	2
GO:0031491	nucleosome binding	4/321	71/18367	0.0356872247557155	0.198735279144214	MBD3/HMGN2/HMGN3/ACTB	4
GO:0001046	core promoter sequence-specific DNA binding	3/321	42/18367	0.0367792718101685	0.201126288187137	STAT1/EZH2/CEBPB	3
GO:0008307	structural constituent of muscle	3/321	42/18367	0.0367792718101685	0.201126288187137	KRT19/TPM4/PLEC	3
GO:0019838	growth factor binding	6/321	141/18367	0.0376227125825348	0.203901665514273	NRP2/HTRA1/FLT1/TGFBR1/IGFBP3/LRP2	6
GO:0055102	lipase inhibitor activity	2/321	18/18367	0.038746959060272	0.204297197124632	ANXA4/ANXA1	2
GO:0098641	cadherin binding involved in cell-cell adhesion	2/321	18/18367	0.038746959060272	0.204297197124632	ANXA1/KRT18	2
GO:0098918	structural constituent of synapse	2/321	18/18367	0.038746959060272	0.204297197124632	ACTG1/ACTB	2
GO:0016504	peptidase activator activity	3/321	43/18367	0.0390419684785129	0.204297197124632	FN1/CAV1/FBLN1	3
GO:0017022	myosin binding	4/321	74/18367	0.0406044618195191	0.210657336106394	CORO1A/CXCR4/FUS/RHOA	4
GO:1901681	sulfur compound binding	9/321	265/18367	0.0439172933022609	0.225913534190444	PTPRC/FN1/NRP2/CCDC80/FBN1/DBI/PGF/ANXA6/SOD3	9
GO:0030506	ankyrin binding	2/321	20/18367	0.0470355861056919	0.237921673051291	PTPRC/PLEC	2
GO:0042288	MHC class I protein binding	2/321	20/18367	0.0470355861056919	0.237921673051291	HLA-E/TUBB	2
GO:0048020	CCR chemokine receptor binding	3/321	48/18367	0.0513817061652789	0.257757815225821	CCL3L3/CCL3/STAT1	3
GO:0043539	protein serine/threonine kinase activator activity	3/321	49/18367	0.0540504554864759	0.268923167871237	IGF2/DBF4/CKS2	3
GO:0033691	sialic acid binding	2/321	22/18367	0.0559038732351153	0.2693146909025	FCN1/SIGLEC6	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/321	22/18367	0.0559038732351153	0.2693146909025	RPL23/RPL37	2
GO:0072349	modified amino acid transmembrane transporter activity	2/321	22/18367	0.0559038732351153	0.2693146909025	SLC6A8/GJA1	2
GO:0120020	cholesterol transfer activity	2/321	22/18367	0.0559038732351153	0.2693146909025	TSPO/NPC2	2
GO:0004601	peroxidase activity	3/321	51/18367	0.0595829544623586	0.282673843108241	GPX3/GPX1/GPX4	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/321	23/18367	0.0605397028073663	0.282673843108241	PARP14/PARP1	2
GO:0070412	R-SMAD binding	2/321	23/18367	0.0605397028073663	0.282673843108241	JUN/PARP1	2
GO:0120015	sterol transfer activity	2/321	23/18367	0.0605397028073663	0.282673843108241	TSPO/NPC2	2
GO:0046982	protein heterodimerization activity	10/321	328/18367	0.0632802339507289	0.293214519145744	CYBB/CAV1/CYBA/BHLHE40/TPM4/SRI/ITGB1/BHLHE41/TOP2A/CEBPB	10
GO:0019957	C-C chemokine binding	2/321	24/18367	0.0653019709874894	0.300290124162167	CXCR4/ZFP36	2
GO:0015631	tubulin binding	11/321	375/18367	0.0661247960056988	0.301787602823001	GAPDH/ALDOA/MX1/EZR/CCSAP/CAPN6/STMN1/PDE4B/DST/S100A9/GJA1	11
GO:0005525	GTP binding	11/321	377/18367	0.0681063064919073	0.306259759654318	MX1/IFI44L/GBP2/RAB17/SAMHD1/CDC42/GBP1/TUBB6/ANXA6/TUBB/RHOA	11
GO:0005544	calcium-dependent phospholipid binding	3/321	54/18367	0.0683569061705508	0.306259759654318	ANXA4/ANXA1/ANXA6	3
GO:0030247	polysaccharide binding	2/321	25/18367	0.0701848736473951	0.306259759654318	HLA-DRB1/HLA-DRA	2
GO:0035035	histone acetyltransferase binding	2/321	25/18367	0.0701848736473951	0.306259759654318	STAT1/CEBPB	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/321	25/18367	0.0701848736473951	0.306259759654318	ZFP36/ZFP36L2	2
GO:0051020	GTPase binding	9/321	291/18367	0.0704889390281423	0.306259759654318	NCF2/FLNA/CAV1/LCP1/ARHGDIB/ENO1/PFN1/IQGAP2/YBX3	9
GO:0043178	alcohol binding	4/321	89/18367	0.0706365178774375	0.306259759654318	TSPO/CAV1/ANXA6/NPC2	4
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/321	55/18367	0.0714047922787996	0.3073950986754	GPX3/GPX1/GPX4	3
GO:0050840	extracellular matrix binding	3/321	56/18367	0.0745127670934903	0.318515842434849	CTSS/PLEKHA2/ITGB1	3
GO:0001664	G protein-coupled receptor binding	9/321	295/18367	0.0753075623090937	0.319662170081258	FCN1/FLNA/CCL3L3/CCL3/WLS/ARRDC3/NPB/STAT1/HSPA1A	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/321	57/18367	0.0776798780256771	0.325295441298814	IFI30/PGK1/GSTO1	3
GO:0043130	ubiquitin binding	4/321	92/18367	0.0777064892723691	0.325295441298814	CXCR4/HSPB1/TOP2A/CKS2	4
GO:0030507	spectrin binding	2/321	27/18367	0.0802901776589461	0.333809163280687	PTPRC/GBP1	2
GO:0051861	glycolipid binding	2/321	28/18367	0.0855017709053966	0.353058332922284	PSAP/PPT1	2
GO:0031406	carboxylic acid binding	6/321	176/18367	0.0889843062775794	0.361924444615538	FCN1/P4HA1/SIGLEC6/PYGL/PSAP/S100A9	6
GO:0004896	cytokine receptor activity	4/321	97/18367	0.0902411271357405	0.361924444615538	CXCR4/IFNGR2/CD74/CSF2RA	4
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/321	29/18367	0.090812374877157	0.361924444615538	BLVRA/DHCR24	2
GO:0051059	NF-kappaB binding	2/321	29/18367	0.090812374877157	0.361924444615538	ANXA4/MTDH	2
GO:0019001	guanyl nucleotide binding	11/321	398/18367	0.0912264250843119	0.361924444615538	MX1/IFI44L/GBP2/RAB17/SAMHD1/CDC42/GBP1/TUBB6/ANXA6/TUBB/RHOA	11
GO:0032561	guanyl ribonucleotide binding	11/321	398/18367	0.0912264250843119	0.361924444615538	MX1/IFI44L/GBP2/RAB17/SAMHD1/CDC42/GBP1/TUBB6/ANXA6/TUBB/RHOA	11
GO:0004867	serine-type endopeptidase inhibitor activity	4/321	98/18367	0.092857881193875	0.366004765484949	SERPINB9/SERPINA1/SERPINB1/TFPI2	4
GO:0000287	magnesium ion binding	7/321	221/18367	0.0937492521389684	0.367134168053896	PKM/NEK6/ENO1/S100P/IDH1/TOP2A/PDCD6	7
GO:1990841	promoter-specific chromatin binding	3/321	62/18367	0.0943677520699423	0.367187342990096	ISL1/STAT1/EZH2	3
GO:0046966	thyroid hormone receptor binding	2/321	30/18367	0.0962169629613214	0.371998066990586	FUS/HMGN3	2
GO:0099106	ion channel regulator activity	5/321	139/18367	0.097034191138006	0.372783253296011	FXYD5/FLNA/CAV1/FXYD3/SRI	5
GO:0005496	steroid binding	4/321	100/18367	0.0981984042397654	0.374883216185771	TSPO/CAV1/ANXA6/NPC2	4
GO:0030295	protein kinase activator activity	4/321	101/18367	0.100921422388902	0.382870646187898	IGF2/HMGB1/DBF4/CKS2	4
GO:0000146	microfilament motor activity	2/321	31/18367	0.101710653018948	0.383468114177027	MYH9/MYH10	2
GO:0004497	monooxygenase activity	4/321	102/18367	0.103679094571548	0.386844361570421	CYP2J2/CYP11A1/CYP19A1/HMOX1	4
GO:0005126	cytokine receptor binding	8/321	271/18367	0.10388077584181	0.386844361570421	TNFSF10/TNFSF13B/CCL3L3/CCL3/PGF/TGFBR1/SIVA1/STAT1	8
GO:0008238	exopeptidase activity	4/321	103/18367	0.106471021192856	0.39407262112234	DPP7/CPVL/CNDP2/TFRC	4
GO:0016247	channel regulator activity	5/321	145/18367	0.110863458889371	0.407843148762717	FXYD5/FLNA/CAV1/FXYD3/SRI	5
GO:0005543	phospholipid binding	12/321	466/18367	0.117895514901534	0.428799966977832	NCF1/ANXA4/ANXA1/CAPG/PHLDA2/HMGB1/PFN1/IQGAP2/PSAP/ANXA6/SNX10/PPT1	12
GO:0019209	kinase activator activity	4/321	107/18367	0.117972972792913	0.428799966977832	IGF2/HMGB1/DBF4/CKS2	4
GO:0005506	iron ion binding	5/321	151/18367	0.125590410990735	0.45377011590105	CYP2J2/P4HA1/FTH1/CYP11A1/CYP19A1	5
GO:0047485	protein N-terminus binding	4/321	110/18367	0.126938267057152	0.455926201796989	RPS21/PARP1/HSPA1A/ID1	4
GO:0032182	ubiquitin-like protein binding	4/321	111/18367	0.12998883950885	0.460029906595225	CXCR4/HSPB1/TOP2A/CKS2	4
GO:0000217	DNA secondary structure binding	2/321	36/18367	0.13035443811265	0.460029906595225	HMGB3/HMGB1	2
GO:0015248	sterol transporter activity	2/321	36/18367	0.13035443811265	0.460029906595225	TSPO/NPC2	2
GO:0042379	chemokine receptor binding	3/321	72/18367	0.131583726386443	0.461683941714283	CCL3L3/CCL3/STAT1	3
GO:0033293	monocarboxylic acid binding	3/321	73/18367	0.13555482469669	0.47288378500512	PYGL/PSAP/S100A9	3
GO:0003924	GTPase activity	9/321	337/18367	0.137771599691368	0.477870634358061	MX1/GBP2/ARHGDIB/RAB17/CDC42/GBP1/TUBB6/TUBB/RHOA	9
GO:0005254	chloride channel activity	3/321	74/18367	0.139566811860514	0.481346902268932	CLIC3/FXYD3/CLIC4	3
GO:0019003	GDP binding	3/321	75/18367	0.143618562625804	0.491007657869363	RAB17/GBP1/RHOA	3
GO:0048018	receptor ligand activity	12/321	487/18367	0.147525641652614	0.491007657869363	TNFSF10/GMFG/TNFSF13B/IGF2/CCL3L3/CCL3/FBN1/PGF/STC2/HMGB1/SEMA6D/NAMPT	12
GO:0019887	protein kinase regulator activity	6/321	204/18367	0.14830575841732	0.491007657869363	GMFG/IGF2/HMGB1/DBF4/HSPB1/CKS2	6
GO:0019825	oxygen binding	2/321	39/18367	0.148326971515912	0.491007657869363	CYP19A1/SOD2	2
GO:0003712	transcription coregulator activity	12/321	489/18367	0.150537728553694	0.491007657869363	PAGE4/FUS/MTDH/PARP14/HMGB1/PA2G4/HSPA1A/MAGED1/EZH2/GMNN/CTNNB1/ARID3A	12
GO:0038024	cargo receptor activity	3/321	77/18367	0.151836856933938	0.491007657869363	ITGB2/LRP2/TFRC	3
GO:0003925	G protein activity	2/321	40/18367	0.154425054200731	0.491007657869363	CDC42/RHOA	2
GO:0017080	sodium channel regulator activity	2/321	40/18367	0.154425054200731	0.491007657869363	FXYD5/FXYD3	2
GO:0030546	signaling receptor activator activity	12/321	495/18367	0.159766202820155	0.491007657869363	TNFSF10/GMFG/TNFSF13B/IGF2/CCL3L3/CCL3/FBN1/PGF/STC2/HMGB1/SEMA6D/NAMPT	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/321	41/18367	0.160570633050388	0.491007657869363	SLC27A2/UBA5	2
GO:0005031	tumor necrosis factor-activated receptor activity	1/321	10/18367	0.161682877285948	0.491007657869363	TNFRSF1B	1
GO:0008239	dipeptidyl-peptidase activity	1/321	10/18367	0.161682877285948	0.491007657869363	DPP7	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/321	10/18367	0.161682877285948	0.491007657869363	UBA5	1
GO:0017002	activin-activated receptor activity	1/321	10/18367	0.161682877285948	0.491007657869363	TGFBR1	1
GO:0030957	Tat protein binding	1/321	10/18367	0.161682877285948	0.491007657869363	ACTB	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/321	10/18367	0.161682877285948	0.491007657869363	SLC27A2	1
GO:0035374	chondroitin sulfate binding	1/321	10/18367	0.161682877285948	0.491007657869363	ANXA6	1
GO:0043208	glycosphingolipid binding	1/321	10/18367	0.161682877285948	0.491007657869363	PSAP	1
GO:0045294	alpha-catenin binding	1/321	10/18367	0.161682877285948	0.491007657869363	CTNNB1	1
GO:0047844	deoxycytidine deaminase activity	1/321	10/18367	0.161682877285948	0.491007657869363	APOBEC3A	1
GO:0070008	serine-type exopeptidase activity	1/321	10/18367	0.161682877285948	0.491007657869363	CPVL	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2/321	42/18367	0.166760201112399	0.491007657869363	NDUFB1/NDUFB7	2
GO:0015036	disulfide oxidoreductase activity	2/321	42/18367	0.166760201112399	0.491007657869363	PGK1/GSTO1	2
GO:0019894	kinesin binding	2/321	42/18367	0.166760201112399	0.491007657869363	NEK6/ACTB	2
GO:0031267	small GTPase binding	7/321	259/18367	0.169300796855934	0.491007657869363	NCF2/FLNA/CAV1/ARHGDIB/PFN1/IQGAP2/YBX3	7
GO:0004180	carboxypeptidase activity	2/321	43/18367	0.172990358801856	0.491007657869363	CPVL/CNDP2	2
GO:0050136	NADH dehydrogenase (quinone) activity	2/321	43/18367	0.172990358801856	0.491007657869363	NDUFB1/NDUFB7	2
GO:0000774	adenyl-nucleotide exchange factor activity	1/321	11/18367	0.176342124243033	0.491007657869363	PFN1	1
GO:0002162	dystroglycan binding	1/321	11/18367	0.176342124243033	0.491007657869363	PLEC	1
GO:0008199	ferric iron binding	1/321	11/18367	0.176342124243033	0.491007657869363	FTH1	1
GO:0008503	benzodiazepine receptor activity	1/321	11/18367	0.176342124243033	0.491007657869363	TSPO	1
GO:0016832	aldehyde-lyase activity	1/321	11/18367	0.176342124243033	0.491007657869363	ALDOA	1
GO:0031996	thioesterase binding	1/321	11/18367	0.176342124243033	0.491007657869363	CDC42	1
GO:0032052	bile acid binding	1/321	11/18367	0.176342124243033	0.491007657869363	PYGL	1
GO:0035673	oligopeptide transmembrane transporter activity	1/321	11/18367	0.176342124243033	0.491007657869363	GJA1	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/321	11/18367	0.176342124243033	0.491007657869363	PGK1	1
GO:0047676	arachidonate-CoA ligase activity	1/321	11/18367	0.176342124243033	0.491007657869363	SLC27A2	1
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	1/321	11/18367	0.176342124243033	0.491007657869363	DSP	1
GO:0097371	MDM2/MDM4 family protein binding	1/321	11/18367	0.176342124243033	0.491007657869363	RPL37	1
GO:0097493	structural molecule activity conferring elasticity	1/321	11/18367	0.176342124243033	0.491007657869363	FBN1	1
GO:0140036	ubiquitin-dependent protein binding	1/321	11/18367	0.176342124243033	0.491007657869363	LAPTM5	1
GO:1990226	histone methyltransferase binding	1/321	11/18367	0.176342124243033	0.491007657869363	CTNNB1	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	5/321	170/18367	0.177567906897275	0.492163102678749	CYP2J2/P4HA1/CYP11A1/CYP19A1/HMOX1	5
GO:0030165	PDZ domain binding	3/321	84/18367	0.181688818837203	0.495511260337732	PLEKHA2/ATP2B1/GJA1	3
GO:0003954	NADH dehydrogenase activity	2/321	45/18367	0.185559365648897	0.495511260337732	NDUFB1/NDUFB7	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	2/321	45/18367	0.185559365648897	0.495511260337732	NDUFB1/NDUFB7	2
GO:0031072	heat shock protein binding	4/321	129/18367	0.189602967368196	0.495511260337732	ITGB2/ZFP36/GBP1/HSPA1A	4
GO:0004126	cytidine deaminase activity	1/321	12/18367	0.190745816666109	0.495511260337732	APOBEC3A	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/321	12/18367	0.190745816666109	0.495511260337732	TGFBR1	1
GO:0005095	GTPase inhibitor activity	1/321	12/18367	0.190745816666109	0.495511260337732	IQGAP2	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/321	12/18367	0.190745816666109	0.495511260337732	CDK1	1
GO:0017154	semaphorin receptor activity	1/321	12/18367	0.190745816666109	0.495511260337732	NRP2	1
GO:0030955	potassium ion binding	1/321	12/18367	0.190745816666109	0.495511260337732	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/321	12/18367	0.190745816666109	0.495511260337732	P4HA1	1
GO:0035325	Toll-like receptor binding	1/321	12/18367	0.190745816666109	0.495511260337732	S100A9	1
GO:0089720	caspase binding	1/321	12/18367	0.190745816666109	0.495511260337732	CARD16	1
GO:0005253	anion channel activity	3/321	87/18367	0.194934314668051	0.495511260337732	CLIC3/FXYD3/CLIC4	3
GO:0008017	microtubule binding	7/321	271/18367	0.197495462309323	0.495511260337732	GAPDH/MX1/EZR/CCSAP/CAPN6/DST/S100A9	7
GO:0051117	ATPase binding	3/321	89/18367	0.20389356971959	0.495511260337732	CAV1/EZR/SNX10	3
GO:0015026	coreceptor activity	2/321	48/18367	0.20463819147878	0.495511260337732	CXCR4/ITGB1	2
GO:0070888	E-box binding	2/321	48/18367	0.20463819147878	0.495511260337732	BHLHE40/BHLHE41	2
GO:0120013	lipid transfer activity	2/321	48/18367	0.20463819147878	0.495511260337732	TSPO/NPC2	2
GO:0005035	death receptor activity	1/321	13/18367	0.204898395955141	0.495511260337732	TNFRSF1B	1
GO:0008195	phosphatidate phosphatase activity	1/321	13/18367	0.204898395955141	0.495511260337732	PLPP3	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/321	13/18367	0.204898395955141	0.495511260337732	PGK1	1
GO:0031386	protein tag	1/321	13/18367	0.204898395955141	0.495511260337732	ISG15	1
GO:0032036	myosin heavy chain binding	1/321	13/18367	0.204898395955141	0.495511260337732	CORO1A	1
GO:0034236	protein kinase A catalytic subunit binding	1/321	13/18367	0.204898395955141	0.495511260337732	EZR	1
GO:0052650	NADP-retinol dehydrogenase activity	1/321	13/18367	0.204898395955141	0.495511260337732	RDH13	1
GO:0060590	ATPase regulator activity	1/321	13/18367	0.204898395955141	0.495511260337732	PFN1	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/321	13/18367	0.204898395955141	0.495511260337732	CKS2	1
GO:0061783	peptidoglycan muralytic activity	1/321	13/18367	0.204898395955141	0.495511260337732	LYZ	1
GO:0072542	protein phosphatase activator activity	1/321	13/18367	0.204898395955141	0.495511260337732	IGFBP3	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/321	13/18367	0.204898395955141	0.495511260337732	LAPTM5	1
GO:0140299	small molecule sensor activity	1/321	13/18367	0.204898395955141	0.495511260337732	EFHD1	1
GO:0008009	chemokine activity	2/321	49/18367	0.21104618024441	0.50835329923951	CCL3L3/CCL3	2
GO:0004298	threonine-type endopeptidase activity	1/321	14/18367	0.218804226558737	0.509414554379396	PSMB9	1
GO:0005172	vascular endothelial growth factor receptor binding	1/321	14/18367	0.218804226558737	0.509414554379396	PGF	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/321	14/18367	0.218804226558737	0.509414554379396	PPT1	1
GO:0015562	efflux transmembrane transporter activity	1/321	14/18367	0.218804226558737	0.509414554379396	GJA1	1
GO:0035259	glucocorticoid receptor binding	1/321	14/18367	0.218804226558737	0.509414554379396	CEBPB	1
GO:0036041	long-chain fatty acid binding	1/321	14/18367	0.218804226558737	0.509414554379396	S100A9	1
GO:0071837	HMG box domain binding	1/321	14/18367	0.218804226558737	0.509414554379396	JUN	1
GO:0098599	palmitoyl hydrolase activity	1/321	14/18367	0.218804226558737	0.509414554379396	PPT1	1
GO:0003743	translation initiation factor activity	2/321	51/18367	0.223918273931479	0.509414554379396	EIF4H/EIF1	2
GO:0019207	kinase regulator activity	6/321	233/18367	0.22396374960611	0.509414554379396	GMFG/IGF2/HMGB1/DBF4/HSPB1/CKS2	6
GO:0005125	cytokine activity	6/321	235/18367	0.229602954803714	0.509414554379396	TNFSF10/TNFSF13B/CCL3L3/CCL3/HMGB1/NAMPT	6
GO:0003714	transcription corepressor activity	5/321	187/18367	0.229754383724405	0.509414554379396	PARP14/PA2G4/HSPA1A/EZH2/GMNN	5
GO:0016830	carbon-carbon lyase activity	2/321	52/18367	0.23037720108694	0.509414554379396	ALDOA/AZIN1	2
GO:0001846	opsonin binding	1/321	15/18367	0.232467597303283	0.509414554379396	ITGB2	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/321	15/18367	0.232467597303283	0.509414554379396	PDE4B	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/321	15/18367	0.232467597303283	0.509414554379396	SLC27A2	1
GO:0005041	low-density lipoprotein particle receptor activity	1/321	15/18367	0.232467597303283	0.509414554379396	LRP2	1
GO:0005545	1-phosphatidylinositol binding	1/321	15/18367	0.232467597303283	0.509414554379396	SNX10	1
GO:0016805	dipeptidase activity	1/321	15/18367	0.232467597303283	0.509414554379396	CNDP2	1
GO:0019215	intermediate filament binding	1/321	15/18367	0.232467597303283	0.509414554379396	VIM	1
GO:0032794	GTPase activating protein binding	1/321	15/18367	0.232467597303283	0.509414554379396	TUBB	1
GO:0048185	activin binding	1/321	15/18367	0.232467597303283	0.509414554379396	TGFBR1	1
GO:0051371	muscle alpha-actinin binding	1/321	15/18367	0.232467597303283	0.509414554379396	PDLIM2	1
GO:1904680	peptide transmembrane transporter activity	1/321	15/18367	0.232467597303283	0.509414554379396	GJA1	1
GO:1990825	sequence-specific mRNA binding	1/321	15/18367	0.232467597303283	0.509414554379396	SSB	1
GO:0050661	NADP binding	2/321	53/18367	0.236848070202755	0.51467890578761	GAPDH/IDH1	2
GO:0019199	transmembrane receptor protein kinase activity	4/321	143/18367	0.240863229870008	0.51467890578761	NRP2/FLT1/TGFBR1/PBK	4
GO:0015459	potassium channel regulator activity	2/321	54/18367	0.243328499588609	0.51467890578761	FLNA/CAV1	2
GO:0004698	calcium-dependent protein kinase C activity	1/321	16/18367	0.245892722699188	0.51467890578761	CCL3	1
GO:0005092	GDP-dissociation inhibitor activity	1/321	16/18367	0.245892722699188	0.51467890578761	ARHGDIB	1
GO:0005159	insulin-like growth factor receptor binding	1/321	16/18367	0.245892722699188	0.51467890578761	IGF2	1
GO:0005523	tropomyosin binding	1/321	16/18367	0.245892722699188	0.51467890578761	S100A6	1
GO:0016004	phospholipase activator activity	1/321	16/18367	0.245892722699188	0.51467890578761	CCL3	1
GO:0016208	AMP binding	1/321	16/18367	0.245892722699188	0.51467890578761	PYGL	1
GO:0035173	histone kinase activity	1/321	16/18367	0.245892722699188	0.51467890578761	CDK1	1
GO:0035497	cAMP response element binding	1/321	16/18367	0.245892722699188	0.51467890578761	JUN	1
GO:0042577	lipid phosphatase activity	1/321	16/18367	0.245892722699188	0.51467890578761	PLPP3	1
GO:0050700	CARD domain binding	1/321	16/18367	0.245892722699188	0.51467890578761	CARD16	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/321	56/18367	0.256308905899993	0.517315239290645	SERPINB9/CARD16	2
GO:0016829	lyase activity	5/321	196/18367	0.259010738037076	0.517315239290645	ALDOA/TPI1/ENO1/HMGB1/AZIN1	5
GO:0004697	protein kinase C activity	1/321	17/18367	0.259083744224639	0.517315239290645	CCL3	1
GO:0005324	long-chain fatty acid transporter activity	1/321	17/18367	0.259083744224639	0.517315239290645	SLC27A2	1
GO:0008392	arachidonic acid epoxygenase activity	1/321	17/18367	0.259083744224639	0.517315239290645	CYP2J2	1
GO:0015095	magnesium ion transmembrane transporter activity	1/321	17/18367	0.259083744224639	0.517315239290645	TUSC3	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/321	17/18367	0.259083744224639	0.517315239290645	PPT1	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/321	17/18367	0.259083744224639	0.517315239290645	FTH1	1
GO:0031420	alkali metal ion binding	1/321	17/18367	0.259083744224639	0.517315239290645	PKM	1
GO:0031489	myosin V binding	1/321	17/18367	0.259083744224639	0.517315239290645	FUS	1
GO:0043395	heparan sulfate proteoglycan binding	1/321	17/18367	0.259083744224639	0.517315239290645	PTPRC	1
GO:0046965	retinoid X receptor binding	1/321	17/18367	0.259083744224639	0.517315239290645	FUS	1
GO:0070064	proline-rich region binding	1/321	17/18367	0.259083744224639	0.517315239290645	PFN1	1
GO:0070628	proteasome binding	1/321	17/18367	0.259083744224639	0.517315239290645	ID1	1
GO:0030674	protein-macromolecule adaptor activity	7/321	296/18367	0.26139697800518	0.520222838193915	CAV1/AP1S2/SYNE1/COL14A1/ICE1/MYH9/PDCD6	7
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	2/321	57/18367	0.262804506913605	0.520363131277572	NDUFB1/NDUFB7	2
GO:0043021	ribonucleoprotein complex binding	4/321	149/18367	0.263743805557418	0.520363131277572	EIF4H/EIF1/EZH2/YBX3	4
GO:0004725	protein tyrosine phosphatase activity	3/321	102/18367	0.2640392824275	0.520363131277572	PTPRC/PTP4A2/PTPRA	3
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/321	58/18367	0.269300912465455	0.527575565729904	SLC16A3/SLC27A2	2
GO:0004708	MAP kinase kinase activity	1/321	18/18367	0.272044731587249	0.527575565729904	PBK	1
GO:0030228	lipoprotein particle receptor activity	1/321	18/18367	0.272044731587249	0.527575565729904	LRP2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/321	18/18367	0.272044731587249	0.527575565729904	CDC42	1
GO:0060229	lipase activator activity	1/321	18/18367	0.272044731587249	0.527575565729904	CCL3	1
GO:0005516	calmodulin binding	5/321	201/18367	0.275634738808055	0.532835307186272	MARCKS/ATP2B1/IQGAP2/MYH9/MYH10	5
GO:0001786	phosphatidylserine binding	2/321	60/18367	0.282288182835025	0.54019146301916	HMGB1/ANXA6	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/321	60/18367	0.282288182835025	0.54019146301916	BLVRA/DHCR24	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/321	19/18367	0.284779683963972	0.54019146301916	GALNT11	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	1/321	19/18367	0.284779683963972	0.54019146301916	TGFBR1	1
GO:0035613	RNA stem-loop binding	1/321	19/18367	0.284779683963972	0.54019146301916	MYH10	1
GO:0035615	clathrin adaptor activity	1/321	19/18367	0.284779683963972	0.54019146301916	AP1S2	1
GO:0019208	phosphatase regulator activity	3/321	107/18367	0.287762410608932	0.542458954160316	ZEB2/IGFBP3/PPP1R10	3
GO:0051087	chaperone binding	3/321	107/18367	0.287762410608932	0.542458954160316	HLA-B/FN1/LRP2	3
GO:0005507	copper ion binding	2/321	61/18367	0.288775242279178	0.542682885645389	F5/SOD3	2
GO:0016500	protein-hormone receptor activity	1/321	20/18367	0.297292531219671	0.548500201976719	LGR5	1
GO:0019211	phosphatase activator activity	1/321	20/18367	0.297292531219671	0.548500201976719	IGFBP3	1
GO:0031418	L-ascorbic acid binding	1/321	20/18367	0.297292531219671	0.548500201976719	P4HA1	1
GO:0031690	adrenergic receptor binding	1/321	20/18367	0.297292531219671	0.548500201976719	ARRDC3	1
GO:0097001	ceramide binding	1/321	20/18367	0.297292531219671	0.548500201976719	PSAP	1
GO:0140312	cargo adaptor activity	1/321	20/18367	0.297292531219671	0.548500201976719	AP1S2	1
GO:0016853	isomerase activity	4/321	158/18367	0.298755415871033	0.549224199432931	CYP2J2/TPI1/ISYNA1/TOP2A	4
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	7/321	310/18367	0.299494579921417	0.549224199432931	ZEB2/BHLHE40/ENO1/BACH1/JUN/BHLHE41/CEBPB	7
GO:0008094	ATP-dependent activity, acting on DNA	3/321	111/18367	0.306857821934393	0.549423250943598	ANXA1/RFC3/TOP2A	3
GO:0001217	DNA-binding transcription repressor activity	7/321	313/18367	0.307815233438301	0.549423250943598	ZEB2/BHLHE40/ENO1/BACH1/JUN/BHLHE41/CEBPB	7
GO:0003713	transcription coactivator activity	6/321	262/18367	0.309417685778273	0.549423250943598	PAGE4/FUS/MTDH/HMGB1/MAGED1/CTNNB1	6
GO:0001848	complement binding	1/321	21/18367	0.309587135104692	0.549423250943598	ITGB2	1
GO:0005243	gap junction channel activity	1/321	21/18367	0.309587135104692	0.549423250943598	GJA1	1
GO:0005385	zinc ion transmembrane transporter activity	1/321	21/18367	0.309587135104692	0.549423250943598	SLC39A10	1
GO:0008391	arachidonic acid monooxygenase activity	1/321	21/18367	0.309587135104692	0.549423250943598	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/321	21/18367	0.309587135104692	0.549423250943598	ATP2B1	1
GO:0051010	microtubule plus-end binding	1/321	21/18367	0.309587135104692	0.549423250943598	DST	1
GO:0140358	P-type transmembrane transporter activity	1/321	21/18367	0.309587135104692	0.549423250943598	ATP2B1	1
GO:0140416	transcription regulator inhibitor activity	1/321	21/18367	0.309587135104692	0.549423250943598	ID1	1
GO:0008509	anion transmembrane transporter activity	7/321	314/18367	0.310599077065443	0.549423250943598	SLC16A3/CLIC3/SLC2A3/SLC6A8/FXYD3/CLIC4/GJA1	7
GO:0000062	fatty-acyl-CoA binding	1/321	22/18367	0.321667290431815	0.549423250943598	DBI	1
GO:0005355	glucose transmembrane transporter activity	1/321	22/18367	0.321667290431815	0.549423250943598	SLC2A3	1
GO:0005540	hyaluronic acid binding	1/321	22/18367	0.321667290431815	0.549423250943598	VCAN	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/321	22/18367	0.321667290431815	0.549423250943598	RDH13	1
GO:0015149	hexose transmembrane transporter activity	1/321	22/18367	0.321667290431815	0.549423250943598	SLC2A3	1
GO:0015645	fatty acid ligase activity	1/321	22/18367	0.321667290431815	0.549423250943598	SLC27A2	1
GO:0017075	syntaxin-1 binding	1/321	22/18367	0.321667290431815	0.549423250943598	STXBP2	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/321	22/18367	0.321667290431815	0.549423250943598	VCAN	1
GO:0030742	GTP-dependent protein binding	1/321	22/18367	0.321667290431815	0.549423250943598	CDC42	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/321	22/18367	0.321667290431815	0.549423250943598	SERPINB9	1
GO:0070182	DNA polymerase binding	1/321	22/18367	0.321667290431815	0.549423250943598	HMGB1	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/321	23/18367	0.333536726232927	0.549423250943598	PDE4B	1
GO:0005158	insulin receptor binding	1/321	23/18367	0.333536726232927	0.549423250943598	IGF2	1
GO:0005212	structural constituent of eye lens	1/321	23/18367	0.333536726232927	0.549423250943598	VIM	1
GO:0008143	poly(A) binding	1/321	23/18367	0.333536726232927	0.549423250943598	HNRNPDL	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/321	23/18367	0.333536726232927	0.549423250943598	CCL3	1
GO:0016493	C-C chemokine receptor activity	1/321	23/18367	0.333536726232927	0.549423250943598	CXCR4	1
GO:0017116	single-stranded DNA helicase activity	1/321	23/18367	0.333536726232927	0.549423250943598	RFC3	1
GO:0030215	semaphorin receptor binding	1/321	23/18367	0.333536726232927	0.549423250943598	SEMA6D	1
GO:0030552	cAMP binding	1/321	23/18367	0.333536726232927	0.549423250943598	PDE4B	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/321	23/18367	0.333536726232927	0.549423250943598	ABHD8	1
GO:0047617	acyl-CoA hydrolase activity	1/321	23/18367	0.333536726232927	0.549423250943598	PPT1	1
GO:0071617	lysophospholipid acyltransferase activity	1/321	23/18367	0.333536726232927	0.549423250943598	ABHD8	1
GO:1901567	fatty acid derivative binding	1/321	23/18367	0.333536726232927	0.549423250943598	DBI	1
GO:0019843	rRNA binding	2/321	68/18367	0.333900893203555	0.549423250943598	RPL23/RPL37	2
GO:0016757	glycosyltransferase activity	6/321	270/18367	0.33399864843194	0.549423250943598	UPP1/PARP14/PYGL/GALNT11/NAMPT/PARP1	6
GO:0035091	phosphatidylinositol binding	6/321	271/18367	0.337089286608301	0.553008640462808	NCF1/CAPG/PHLDA2/PFN1/IQGAP2/SNX10	6
GO:0004197	cysteine-type endopeptidase activity	3/321	119/18367	0.345140292419904	0.557276217781206	CTSS/CTSB/CTSL	3
GO:0010857	calcium-dependent protein kinase activity	1/321	24/18367	0.345199106895771	0.557276217781206	CCL3	1
GO:0015145	monosaccharide transmembrane transporter activity	1/321	24/18367	0.345199106895771	0.557276217781206	SLC2A3	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/321	24/18367	0.345199106895771	0.557276217781206	GAPDH	1
GO:0050431	transforming growth factor beta binding	1/321	24/18367	0.345199106895771	0.557276217781206	TGFBR1	1
GO:0070003	threonine-type peptidase activity	1/321	24/18367	0.345199106895771	0.557276217781206	PSMB9	1
GO:0004860	protein kinase inhibitor activity	2/321	70/18367	0.346656393373811	0.558046132382081	GMFG/HSPB1	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/321	25/18367	0.356658033281121	0.558046132382081	PDE4B	1
GO:0005112	Notch binding	1/321	25/18367	0.356658033281121	0.558046132382081	GALNT11	1
GO:0005160	transforming growth factor beta receptor binding	1/321	25/18367	0.356658033281121	0.558046132382081	TGFBR1	1
GO:0008266	poly(U) RNA binding	1/321	25/18367	0.356658033281121	0.558046132382081	SSB	1
GO:0008327	methyl-CpG binding	1/321	25/18367	0.356658033281121	0.558046132382081	MBD3	1
GO:0016289	CoA hydrolase activity	1/321	25/18367	0.356658033281121	0.558046132382081	PPT1	1
GO:0034237	protein kinase A regulatory subunit binding	1/321	25/18367	0.356658033281121	0.558046132382081	EZR	1
GO:0070330	aromatase activity	1/321	25/18367	0.356658033281121	0.558046132382081	CYP19A1	1
GO:0120227	acyl-CoA binding	1/321	25/18367	0.356658033281121	0.558046132382081	DBI	1
GO:1901981	phosphatidylinositol phosphate binding	4/321	173/18367	0.358083273920036	0.558046132382081	CAPG/PHLDA2/PFN1/IQGAP2	4
GO:0003678	DNA helicase activity	2/321	72/18367	0.359330571483519	0.558046132382081	ANXA1/RFC3	2
GO:0008235	metalloexopeptidase activity	2/321	72/18367	0.359330571483519	0.558046132382081	CNDP2/TFRC	2
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	2/321	72/18367	0.359330571483519	0.558046132382081	NDUFB1/NDUFB7	2
GO:0005179	hormone activity	3/321	122/18367	0.359466289557485	0.558046132382081	IGF2/FBN1/STC2	3
GO:0003697	single-stranded DNA binding	3/321	123/18367	0.364232451960573	0.559946793565842	ANXA1/SAMHD1/HMGB1	3
GO:0001637	G protein-coupled chemoattractant receptor activity	1/321	26/18367	0.367917043820689	0.559946793565842	CXCR4	1
GO:0004364	glutathione transferase activity	1/321	26/18367	0.367917043820689	0.559946793565842	GSTO1	1
GO:0004950	chemokine receptor activity	1/321	26/18367	0.367917043820689	0.559946793565842	CXCR4	1
GO:0008198	ferrous iron binding	1/321	26/18367	0.367917043820689	0.559946793565842	FTH1	1
GO:0038187	pattern recognition receptor activity	1/321	26/18367	0.367917043820689	0.559946793565842	FCN1	1
GO:0042974	retinoic acid receptor binding	1/321	26/18367	0.367917043820689	0.559946793565842	FUS	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	3/321	124/18367	0.368992944689187	0.559946793565842	NRP2/FLT1/PBK	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3/321	124/18367	0.368992944689187	0.559946793565842	LDHA/RDH13/IDH1	3
GO:0019210	kinase inhibitor activity	2/321	74/18367	0.371913760918362	0.562446519967866	GMFG/HSPB1	2
GO:0016405	CoA-ligase activity	1/321	27/18367	0.378979615596141	0.562446519967866	SLC27A2	1
GO:0016866	intramolecular transferase activity	1/321	27/18367	0.378979615596141	0.562446519967866	CYP2J2	1
GO:0035255	ionotropic glutamate receptor binding	1/321	27/18367	0.378979615596141	0.562446519967866	FUS	1
GO:0045499	chemorepellent activity	1/321	27/18367	0.378979615596141	0.562446519967866	SEMA6D	1
GO:0048027	mRNA 5'-UTR binding	1/321	27/18367	0.378979615596141	0.562446519967866	MYH10	1
GO:0051119	sugar transmembrane transporter activity	1/321	27/18367	0.378979615596141	0.562446519967866	SLC2A3	1
GO:0051393	alpha-actinin binding	1/321	27/18367	0.378979615596141	0.562446519967866	PDLIM2	1
GO:0051959	dynein light intermediate chain binding	1/321	27/18367	0.378979615596141	0.562446519967866	DYNLL1	1
GO:0008187	poly-pyrimidine tract binding	1/321	28/18367	0.389849165399501	0.57436515387742	SSB	1
GO:0046875	ephrin receptor binding	1/321	28/18367	0.389849165399501	0.57436515387742	EFNB1	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/321	28/18367	0.389849165399501	0.57436515387742	PDCD6	1
GO:0004033	aldo-keto reductase (NADP) activity	1/321	29/18367	0.400529050775299	0.581629506747863	RDH13	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/321	29/18367	0.400529050775299	0.581629506747863	CDK1	1
GO:0046625	sphingolipid binding	1/321	29/18367	0.400529050775299	0.581629506747863	PSAP	1
GO:0051787	misfolded protein binding	1/321	29/18367	0.400529050775299	0.581629506747863	HSPA1A	1
GO:0070717	poly-purine tract binding	1/321	29/18367	0.400529050775299	0.581629506747863	HNRNPDL	1
GO:0097472	cyclin-dependent protein kinase activity	1/321	29/18367	0.400529050775299	0.581629506747863	CDK1	1
GO:0016835	carbon-oxygen lyase activity	2/321	79/18367	0.402916997955546	0.58370075837474	TPI1/ENO1	2
GO:0008514	organic anion transmembrane transporter activity	4/321	185/18367	0.405569991583412	0.58614520212174	SLC16A3/SLC2A3/SLC6A8/GJA1	4
GO:0017147	Wnt-protein binding	1/321	30/18367	0.411022571044747	0.591210191052515	WLS	1
GO:0022829	wide pore channel activity	1/321	30/18367	0.411022571044747	0.591210191052515	GJA1	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	2/321	82/18367	0.421169163644169	0.598944055657026	CAPG/PFN1	2
GO:0016878	acid-thiol ligase activity	1/321	31/18367	0.421332968312274	0.598944055657026	SLC27A2	1
GO:0043015	gamma-tubulin binding	1/321	31/18367	0.421332968312274	0.598944055657026	PDE4B	1
GO:0090482	vitamin transmembrane transporter activity	1/321	31/18367	0.421332968312274	0.598944055657026	SLC2A3	1
GO:0140318	protein transporter activity	1/321	31/18367	0.421332968312274	0.598944055657026	LRP2	1
GO:0042393	histone binding	5/321	244/18367	0.423440275461854	0.598949613113674	MORC4/DEK/STAT1/CTSL/CKS2	5
GO:0008237	metallopeptidase activity	4/321	190/18367	0.425185268410062	0.598949613113674	ADAM12/ADAMTS6/CNDP2/TFRC	4
GO:0004713	protein tyrosine kinase activity	3/321	136/18367	0.425459330986138	0.598949613113674	NRP2/FLT1/PBK	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3/321	136/18367	0.425459330986138	0.598949613113674	LDHA/RDH13/IDH1	3
GO:0008236	serine-type peptidase activity	4/321	191/18367	0.429089967634846	0.598949613113674	CTSS/DPP7/HTRA1/CPVL	4
GO:0001223	transcription coactivator binding	1/321	32/18367	0.431463428454712	0.598949613113674	RPL23	1
GO:0030332	cyclin binding	1/321	32/18367	0.431463428454712	0.598949613113674	CDK1	1
GO:0050699	WW domain binding	1/321	32/18367	0.431463428454712	0.598949613113674	LITAF	1
GO:0051721	protein phosphatase 2A binding	1/321	32/18367	0.431463428454712	0.598949613113674	STAT1	1
GO:0071889	14-3-3 protein binding	1/321	32/18367	0.431463428454712	0.598949613113674	ZFP36	1
GO:0001540	amyloid-beta binding	2/321	84/18367	0.433177726782377	0.598949613113674	ITGB2/CD74	2
GO:0008135	translation factor activity, RNA binding	2/321	84/18367	0.433177726782377	0.598949613113674	EIF4H/EIF1	2
GO:0008013	beta-catenin binding	2/321	85/18367	0.439131966638254	0.603468848717831	CTNNB1/GJA1	2
GO:0050660	flavin adenine dinucleotide binding	2/321	85/18367	0.439131966638254	0.603468848717831	CYBB/DHCR24	2
GO:0001530	lipopolysaccharide binding	1/321	33/18367	0.441417082093438	0.603468848717831	HMGB1	1
GO:0008200	ion channel inhibitor activity	1/321	33/18367	0.441417082093438	0.603468848717831	CAV1	1
GO:0019239	deaminase activity	1/321	33/18367	0.441417082093438	0.603468848717831	APOBEC3A	1
GO:0017171	serine hydrolase activity	4/321	195/18367	0.44463686092736	0.604584067039068	CTSS/DPP7/HTRA1/CPVL	4
GO:0042562	hormone binding	2/321	86/18367	0.445051958781935	0.604584067039068	TSPO/LRP2	2
GO:0008376	acetylgalactosaminyltransferase activity	1/321	34/18367	0.451197005549749	0.604584067039068	GALNT11	1
GO:0016248	channel inhibitor activity	1/321	34/18367	0.451197005549749	0.604584067039068	CAV1	1
GO:0016831	carboxy-lyase activity	1/321	34/18367	0.451197005549749	0.604584067039068	AZIN1	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/321	34/18367	0.451197005549749	0.604584067039068	HSPB1	1
GO:0035198	miRNA binding	1/321	34/18367	0.451197005549749	0.604584067039068	SOX4	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/321	34/18367	0.451197005549749	0.604584067039068	CORO1A	1
GO:0045505	dynein intermediate chain binding	1/321	34/18367	0.451197005549749	0.604584067039068	DYNLL1	1
GO:0042578	phosphoric ester hydrolase activity	7/321	366/18367	0.458290688187471	0.612736669008359	PTPRC/SAMHD1/PTP4A2/PDE4B/HMOX1/PTPRA/PLPP3	7
GO:0042887	amide transmembrane transporter activity	1/321	35/18367	0.460806221783782	0.614438571828301	GJA1	1
GO:0008081	phosphoric diester hydrolase activity	2/321	89/18367	0.462600374506645	0.614438571828301	PDE4B/HMOX1	2
GO:0019888	protein phosphatase regulator activity	2/321	89/18367	0.462600374506645	0.614438571828301	IGFBP3/PPP1R10	2
GO:0060090	molecular adaptor activity	7/321	369/18367	0.466752862878077	0.617836265583478	CAV1/AP1S2/SYNE1/COL14A1/ICE1/MYH9/PDCD6	7
GO:0003730	mRNA 3'-UTR binding	4/321	201/18367	0.467708393746664	0.617836265583478	ZFP36/FUS/ZFP36L2/YBX3	4
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/321	36/18367	0.470247701317244	0.617836265583478	APOBEC3A	1
GO:0042805	actinin binding	1/321	36/18367	0.470247701317244	0.617836265583478	PDLIM2	1
GO:0061631	ubiquitin conjugating enzyme activity	1/321	36/18367	0.470247701317244	0.617836265583478	UBE2J1	1
GO:0015035	protein-disulfide reductase activity	1/321	37/18367	0.47952436314023	0.623278990205824	PGK1	1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/321	37/18367	0.47952436314023	0.623278990205824	GAPDH	1
GO:0030551	cyclic nucleotide binding	1/321	37/18367	0.47952436314023	0.623278990205824	PDE4B	1
GO:0046915	transition metal ion transmembrane transporter activity	1/321	37/18367	0.47952436314023	0.623278990205824	SLC39A10	1
GO:0071949	FAD binding	1/321	37/18367	0.47952436314023	0.623278990205824	DHCR24	1
GO:0072341	modified amino acid binding	2/321	93/18367	0.485484530881151	0.629677585993287	HMGB1/ANXA6	2
GO:0015175	neutral amino acid transmembrane transporter activity	1/321	38/18367	0.488639075602422	0.63241773750676	SLC43A2	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	1/321	39/18367	0.497594657288909	0.637424814091538	POLR2L	1
GO:0005504	fatty acid binding	1/321	39/18367	0.497594657288909	0.637424814091538	S100A9	1
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	1/321	39/18367	0.497594657288909	0.637424814091538	IQGAP2	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/321	39/18367	0.497594657288909	0.637424814091538	UBE2J1	1
GO:0015103	inorganic anion transmembrane transporter activity	3/321	152/18367	0.497758421547593	0.637424814091538	CLIC3/FXYD3/CLIC4	3
GO:0004177	aminopeptidase activity	1/321	40/18367	0.506393877880914	0.643166756368068	DPP7	1
GO:0015144	carbohydrate transmembrane transporter activity	1/321	40/18367	0.506393877880914	0.643166756368068	SLC2A3	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/321	40/18367	0.506393877880914	0.643166756368068	SERPINB9	1
GO:0005319	lipid transporter activity	3/321	154/18367	0.50648057585492	0.643166756368068	TSPO/SLC27A2/NPC2	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	1/321	41/18367	0.515039459001677	0.652670045123211	COL14A1	1
GO:0005246	calcium channel regulator activity	1/321	43/18367	0.531880354005993	0.667048295209995	SRI	1
GO:0016790	thiolester hydrolase activity	1/321	43/18367	0.531880354005993	0.667048295209995	PPT1	1
GO:0018024	histone-lysine N-methyltransferase activity	1/321	43/18367	0.531880354005993	0.667048295209995	EZH2	1
GO:0034062	5'-3' RNA polymerase activity	1/321	43/18367	0.531880354005993	0.667048295209995	POLR2L	1
GO:0097747	RNA polymerase activity	1/321	43/18367	0.531880354005993	0.667048295209995	POLR2L	1
GO:0001784	phosphotyrosine residue binding	1/321	44/18367	0.540080878256379	0.671000809601249	PFN1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/321	44/18367	0.540080878256379	0.671000809601249	PBK	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/321	44/18367	0.540080878256379	0.671000809601249	GAPDH	1
GO:0051879	Hsp90 protein binding	1/321	44/18367	0.540080878256379	0.671000809601249	GBP1	1
GO:0008083	growth factor activity	3/321	162/18367	0.540559136565091	0.671000809601249	GMFG/IGF2/PGF	3
GO:0046943	carboxylic acid transmembrane transporter activity	3/321	163/18367	0.544723683896114	0.674790359438655	SLC16A3/SLC27A2/SLC43A2	3
GO:0048156	tau protein binding	1/321	45/18367	0.548138185361094	0.677158234321724	ACTB	1
GO:0005342	organic acid transmembrane transporter activity	3/321	164/18367	0.548866311839025	0.677158234321724	SLC16A3/SLC27A2/SLC43A2	3
GO:0004864	protein phosphatase inhibitor activity	1/321	46/18367	0.556054768839923	0.683249483169703	PPP1R10	1
GO:0061980	regulatory RNA binding	1/321	46/18367	0.556054768839923	0.683249483169703	SOX4	1
GO:1902936	phosphatidylinositol bisphosphate binding	2/321	107/18367	0.560611680048701	0.687242327132338	CAPG/PFN1	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	1/321	47/18367	0.563833078932297	0.687242327132338	PTP4A2	1
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/321	47/18367	0.563833078932297	0.687242327132338	ATP2B1	1
GO:0035254	glutamate receptor binding	1/321	47/18367	0.563833078932297	0.687242327132338	FUS	1
GO:0090079	translation regulator activity, nucleic acid binding	2/321	108/18367	0.565669842795419	0.688099387929498	EIF4H/EIF1	2
GO:0019212	phosphatase inhibitor activity	1/321	49/18367	0.578984467994155	0.702887144144904	PPP1R10	1
GO:0004222	metalloendopeptidase activity	2/321	111/18367	0.580592469205054	0.703432392829277	ADAM12/ADAMTS6	2
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/321	50/18367	0.586362237716498	0.709007725685089	CKS2	1
GO:0004721	phosphoprotein phosphatase activity	3/321	174/18367	0.589046832793402	0.710837828042932	PTPRC/PTP4A2/PTPRA	3
GO:0016860	intramolecular oxidoreductase activity	1/321	51/18367	0.593611116992199	0.713508807949039	TPI1	1
GO:0051018	protein kinase A binding	1/321	51/18367	0.593611116992199	0.713508807949039	EZR	1
GO:0003774	cytoskeletal motor activity	2/321	114/18367	0.595136024815495	0.713927998148232	MYH9/MYH10	2
GO:1901682	sulfur compound transmembrane transporter activity	1/321	52/18367	0.6007333506374	0.719221190999806	GJA1	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/321	53/18367	0.607731144491912	0.726166938398801	SLC16A3	1
GO:0008374	O-acyltransferase activity	1/321	54/18367	0.614606666093861	0.731456640564101	CROT	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	1/321	54/18367	0.614606666093861	0.731456640564101	P4HA1	1
GO:0015399	primary active transmembrane transporter activity	3/321	181/18367	0.615773218003716	0.731456640564101	ATP2B1/NDUFB1/NDUFB7	3
GO:0030170	pyridoxal phosphate binding	1/321	55/18367	0.621362045342694	0.736653831099639	PYGL	1
GO:0042054	histone methyltransferase activity	1/321	56/18367	0.627999375150743	0.738954072077966	EZH2	1
GO:0045309	protein phosphorylated amino acid binding	1/321	56/18367	0.627999375150743	0.738954072077966	PFN1	1
GO:0070279	vitamin B6 binding	1/321	56/18367	0.627999375150743	0.738954072077966	PYGL	1
GO:0004175	endopeptidase activity	7/321	430/18367	0.628171830629705	0.738954072077966	CTSS/PSMB9/HTRA1/ADAM12/ADAMTS6/CTSB/CTSL	7
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/321	58/18367	0.64092807698913	0.75250163004333	GSTO1	1
GO:0016279	protein-lysine N-methyltransferase activity	1/321	59/18367	0.647223455616389	0.756858202286667	EZH2	1
GO:0036002	pre-mRNA binding	1/321	59/18367	0.647223455616389	0.756858202286667	TRA2B	1
GO:0008234	cysteine-type peptidase activity	3/321	190/18367	0.648379349570127	0.756858202286667	CTSS/CTSB/CTSL	3
GO:0016278	lysine N-methyltransferase activity	1/321	60/18367	0.653408799222853	0.761265146119523	EZH2	1
GO:0015179	L-amino acid transmembrane transporter activity	1/321	61/18367	0.659486025171914	0.765407298813292	SLC43A2	1
GO:0043621	protein self-association	1/321	61/18367	0.659486025171914	0.765407298813292	PLEC	1
GO:0016779	nucleotidyltransferase activity	2/321	132/18367	0.674468733799263	0.780207932356643	POLR2L/UGP2	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	7/321	450/18367	0.67480916719479	0.780207932356643	BACH1/ISL1/LITAF/JUN/REL/SOX4/CEBPB	7
GO:0016836	hydro-lyase activity	1/321	64/18367	0.677087674551508	0.781354027476741	ENO1	1
GO:0030145	manganese ion binding	1/321	65/18367	0.682750945953408	0.783878659221083	SOD2	1
GO:0005244	voltage-gated ion channel activity	3/321	201/18367	0.68550412889686	0.783878659221083	CYBB/CLIC3/CLIC4	3
GO:0022832	voltage-gated channel activity	3/321	201/18367	0.68550412889686	0.783878659221083	CYBB/CLIC3/CLIC4	3
GO:0015085	calcium ion transmembrane transporter activity	2/321	135/18367	0.686393024861346	0.783878659221083	ATP2B1/ANXA6	2
GO:0043177	organic acid binding	2/321	135/18367	0.686393024861346	0.783878659221083	P4HA1/S100A9	2
GO:0001216	DNA-binding transcription activator activity	7/321	456/18367	0.688069518388919	0.783878659221083	BACH1/ISL1/LITAF/JUN/REL/SOX4/CEBPB	7
GO:0002039	p53 binding	1/321	66/18367	0.688315198294625	0.783878659221083	PTTG1IP	1
GO:0003684	damaged DNA binding	1/321	68/18367	0.699153519705246	0.794730686256712	HMGB1	1
GO:0045182	translation regulator activity	2/321	140/18367	0.705469666050198	0.800411378116767	EIF4H/EIF1	2
GO:0016791	phosphatase activity	4/321	275/18367	0.711169066622627	0.805372431790922	PTPRC/PTP4A2/PTPRA/PLPP3	4
GO:0000049	tRNA binding	1/321	72/18367	0.719715896084315	0.81004172202805	SSB	1
GO:0030276	clathrin binding	1/321	72/18367	0.719715896084315	0.81004172202805	AP1S2	1
GO:0015293	symporter activity	2/321	144/18367	0.72002812453031	0.81004172202805	SLC16A3/SLC6A8	2
GO:0015370	solute:sodium symporter activity	1/321	73/18367	0.724633698618173	0.81004172202805	SLC6A8	1
GO:0035064	methylated histone binding	1/321	73/18367	0.724633698618173	0.81004172202805	MORC4	1
GO:0070063	RNA polymerase binding	1/321	73/18367	0.724633698618173	0.81004172202805	ZFP36	1
GO:0140034	methylation-dependent protein binding	1/321	73/18367	0.724633698618173	0.81004172202805	MORC4	1
GO:0019905	syntaxin binding	1/321	74/18367	0.729465478586664	0.813654238066617	STXBP2	1
GO:0008528	G protein-coupled peptide receptor activity	2/321	147/18367	0.730546226929665	0.813654238066617	CXCR4/LGR5	2
GO:0019842	vitamin binding	2/321	148/18367	0.733977173758763	0.815978286577966	P4HA1/PYGL	2
GO:0019903	protein phosphatase binding	2/321	150/18367	0.74072788695765	0.821977746587374	STAT1/CTNNB1	2
GO:0001653	peptide receptor activity	2/321	153/18367	0.750579729353077	0.831390320652039	CXCR4/LGR5	2
GO:0034987	immunoglobulin receptor binding	1/321	79/18367	0.752385639884258	0.831872647376584	FLNA	1
GO:0004386	helicase activity	2/321	156/18367	0.760108590750988	0.838883481065181	ANXA1/RFC3	2
GO:0140097	catalytic activity, acting on DNA	3/321	229/18367	0.766631556127529	0.844546922993484	ANXA1/RFC3/TOP2A	3
GO:0140030	modification-dependent protein binding	2/321	160/18367	0.77232345957725	0.848888401854648	LAPTM5/MORC4	2
GO:0015171	amino acid transmembrane transporter activity	1/321	84/18367	0.773369499547974	0.848888401854648	SLC43A2	1
GO:0016874	ligase activity	2/321	165/18367	0.786828033673275	0.861233140758659	SLC27A2/UBA5	2
GO:0008276	protein methyltransferase activity	1/321	88/18367	0.788872530909084	0.861233140758659	EZH2	1
GO:0051219	phosphoprotein binding	1/321	88/18367	0.788872530909084	0.861233140758659	PFN1	1
GO:0051213	dioxygenase activity	1/321	92/18367	0.803318129183028	0.875429271838596	P4HA1	1
GO:0004674	protein serine/threonine kinase activity	5/321	386/18367	0.807955350747016	0.878904834952399	CCL3/NEK6/TGFBR1/CDK1/PBK	5
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	1/321	94/18367	0.810167058999732	0.878957155243844	LYZ	1
GO:0004252	serine-type endopeptidase activity	2/321	174/18367	0.810899517193662	0.878957155243844	CTSS/HTRA1	2
GO:0008170	N-methyltransferase activity	1/321	97/18367	0.81999720149288	0.887234048674115	EZH2	1
GO:0022804	active transmembrane transporter activity	5/321	406/18367	0.840942623374284	0.90512463576728	SLC16A3/SLC6A8/ATP2B1/NDUFB1/NDUFB7	5
GO:0004620	phospholipase activity	1/321	104/18367	0.8410054276322	0.90512463576728	HMOX1	1
GO:0015294	solute:cation symporter activity	1/321	104/18367	0.8410054276322	0.90512463576728	SLC6A8	1
GO:1990782	protein tyrosine kinase binding	1/321	105/18367	0.843799999045991	0.906524954727286	ITGB1	1
GO:0015267	channel activity	6/321	480/18367	0.847701505927139	0.907366609015381	CYBB/CLIC3/FXYD3/CLIC4/ANXA6/GJA1	6
GO:0022836	gated channel activity	4/321	340/18367	0.848437081792815	0.907366609015381	CYBB/CLIC3/CLIC4/ANXA6	4
GO:0022803	passive transmembrane transporter activity	6/321	481/18367	0.849067930676666	0.907366609015381	CYBB/CLIC3/FXYD3/CLIC4/ANXA6/GJA1	6
GO:0042626	ATPase-coupled transmembrane transporter activity	1/321	109/18367	0.854497079685758	0.911563668487267	ATP2B1	1
GO:0000149	SNARE binding	1/321	110/18367	0.857055215156284	0.912443641859266	STXBP2	1
GO:0030594	neurotransmitter receptor activity	1/321	111/18367	0.85956851284675	0.912443641859266	TSPO	1
GO:0019902	phosphatase binding	2/321	196/18367	0.859831570252883	0.912443641859266	STAT1/CTNNB1	2
GO:0016758	hexosyltransferase activity	2/321	197/18367	0.861754433993505	0.912888204946	PYGL/GALNT11	2
GO:0004540	ribonuclease activity	1/321	116/18367	0.871489383739386	0.921592431933462	SAMHD1	1
GO:0046873	metal ion transmembrane transporter activity	5/321	430/18367	0.874249149097396	0.922903014786294	SLC6A8/ATP2B1/ANXA6/SLC39A10/TUSC3	5
GO:0005262	calcium channel activity	1/321	119/18367	0.878151944916223	0.925413594729422	ANXA6	1
GO:0051082	unfolded protein binding	1/321	122/18367	0.884470109554555	0.930456423742834	HSPA1A	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/321	125/18367	0.890461627209832	0.935138767675378	APOBEC3A	1
GO:0016298	lipase activity	1/321	129/18367	0.897971176232645	0.941396379919198	HMOX1	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	2/321	222/18367	0.902620402095376	0.944638938054989	CROT/ABHD8	2
GO:0070851	growth factor receptor binding	1/321	141/18367	0.917557396428165	0.956504733800114	PGF	1
GO:0008194	UDP-glycosyltransferase activity	1/321	143/18367	0.920435893483874	0.956504733800114	GALNT11	1
GO:0015276	ligand-gated ion channel activity	1/321	143/18367	0.920435893483874	0.956504733800114	ANXA6	1
GO:0022834	ligand-gated channel activity	1/321	143/18367	0.920435893483874	0.956504733800114	ANXA6	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	1/321	144/18367	0.921837346413619	0.956504733800114	LYZ	1
GO:0015291	secondary active transmembrane transporter activity	2/321	240/18367	0.924748069622899	0.957442465998239	SLC16A3/SLC6A8	2
GO:0052689	carboxylic ester hydrolase activity	1/321	147/18367	0.925895762011477	0.957442465998239	ABHD8	1
GO:0015081	sodium ion transmembrane transporter activity	1/321	152/18367	0.932198274361877	0.962320327444999	SLC6A8	1
GO:0016746	acyltransferase activity	2/321	250/18367	0.934903563623542	0.963474470491494	CROT/ABHD8	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	1/321	156/18367	0.936853219902687	0.963847295730392	EZH2	1
GO:0005216	ion channel activity	4/321	432/18367	0.94626340033376	0.971881360410478	CLIC3/FXYD3/CLIC4/ANXA6	4
GO:0022853	active ion transmembrane transporter activity	2/321	267/18367	0.94925668678086	0.973308798776997	SLC6A8/ATP2B1	2
GO:0106310	protein serine kinase activity	3/321	360/18367	0.952740387102489	0.973723373315728	NEK6/CDK1/PBK	3
GO:0016887	ATP hydrolysis activity	2/321	272/18367	0.952869330724122	0.973723373315728	ATP2B1/HSPA1A	2
GO:0005096	GTPase activator activity	4/321	462/18367	0.962617548355526	0.982031683784545	EPS8L1/ARHGDIB/IQGAP2/JUN	4
GO:0030695	GTPase regulator activity	4/321	488/18367	0.972930765182062	0.989227762923805	EPS8L1/ARHGDIB/IQGAP2/JUN	4
GO:0060589	nucleoside-triphosphatase regulator activity	4/321	488/18367	0.972930765182062	0.989227762923805	EPS8L1/ARHGDIB/IQGAP2/JUN	4
GO:0004518	nuclease activity	1/321	210/18367	0.975863673983361	0.990550585464716	SAMHD1	1
GO:0008168	methyltransferase activity	1/321	214/18367	0.977525912853082	0.990581350754292	EZH2	1
GO:0005085	guanyl-nucleotide exchange factor activity	1/321	223/18367	0.980860465008084	0.991330703821861	EPS8L1	1
GO:0016741	transferase activity, transferring one-carbon groups	1/321	225/18367	0.981531718281612	0.991330703821861	EZH2	1
GO:0140098	catalytic activity, acting on RNA	2/321	386/18367	0.991748397346362	0.997423733548973	SAMHD1/POLR2L	2
GO:0061630	ubiquitin protein ligase activity	1/321	304/18367	0.995506344195725	0.997423733548973	CDC42	1
GO:0004842	ubiquitin-protein transferase activity	2/321	433/18367	0.996079136943519	0.997423733548973	CDC42/UBE2J1	2
GO:0061659	ubiquitin-like protein ligase activity	1/321	316/18367	0.996376540619666	0.997423733548973	CDC42	1
GO:0019787	ubiquitin-like protein transferase activity	2/321	458/18367	0.997373318815507	0.997423733548973	CDC42/UBE2J1	2
GO:0005261	cation channel activity	1/321	335/18367	0.997423733548973	0.997423733548973	ANXA6	1