ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	116/2130	182/18367	2.91300444067942e-63	3.15769681369649e-60	RPS21/RPS27/MRPL15/RPS29/MRPL33/RPL39/RPS28/MRPL55/RPL37A/RPL18/MRPL36/RPS18/RPL7L1/RPL36/RPS23/MRPS7/RPS7/RPL38/RPS14/RPS15A/RPL37/RPL41/RPS19/MRPL34/RPL34/RPL27/MRPL20/RPS15/RPL12/RPS24/RPL30/MRPS14/RPS27A/RPL10A/RPL11/RPL5/RPL22/RPS8/RPL32/RPL10/RPL27A/RPL23/RPS3/RPSA/RPL35A/RPL28/RPS5/MRPS31/MRPL51/RPLP1/MRPL11/RPL26/MRPL21/MRPL54/MRPL27/RPS2/MRPS15/RPL15/RPS16/MRPS6/MRPS21/RPS17/RPS9/RSL24D1/RPL3/RPS4X/RPL7A/MRPL57/RPLP2/RPS12/MRPL16/RPL13/MRPL1/RPS10/MRPS23/RPS4Y1/RPL35/MRPL42/MRPS34/RPL9/RPS25/DAP3/RPL26L1/MRPL43/RPL19/RPS6/MRPL3/MRPL47/RPL23A/MRPL41/RPS13/RPLP0/RPS26/RPL29/RPL36AL/RPS11/RPL18A/RPL7/MRPL19/RPL21/RPL6/MRPL4/MRPS36/RPL24/RPL31/RPS3A/RPL14/RPL22L1/RPL13A/MRPS33/RPL8/MRPS16/MRPL44/RPS27L/RPS20/RPL36A	116
GO:0045296	cadherin binding	117/2130	332/18367	4.33481474393692e-30	2.34946959121381e-27	SPTAN1/EGFR/CD46/PLEC/ANK3/CDH1/ITGA6/TRIM29/DOCK9/AHNAK/IQGAP1/ARGLU1/HSPA5/CTNND1/EPN2/ITGB1/PPP1R13L/BAIAP2/PTPRM/IDH1/P2RX4/CALD1/SND1/ARHGAP18/RTN4/PDXDC1/RDX/SPTBN1/KRT18/ATXN2L/MB21D2/LIMA1/HSPA8/SLK/ANXA2/TJP1/PSMB6/KTN1/S100A11/LRRFIP1/RPL34/PARK7/PRDX1/EIF3E/CAPZB/LRRC59/NCK1/HSP90AB1/YWHAE/EZR/ABI1/YWHAZ/FNBP1L/DDX3X/PPFIBP1/CTNNB1/PLIN3/SERBP1/RPS2/RPL15/BZW2/YWHAB/ENO1/PSEN1/RPL7A/KIF5B/CAST/MPP7/ATIC/ANXA1/IST1/MACF1/COBLL1/CLIC1/GLOD4/EEF1D/PTPN11/CTTN/CSNK1D/GCN1/LYPLA2/RPL23A/PFN1/EIF4G2/PCBP1/USP8/PTPN1/EPS8L2/RPS26/RPL29/CDC42EP1/FMNL2/S100P/EEF2/JUP/STK38/RPL6/CHMP5/DLG1/SNX5/RAB1A/TLN1/SWAP70/RPL24/NUMB/RPL14/ALDOA/PKN2/DNAJB1/SNX2/PPP1CA/VASP/RAN/DBNL/CNN3/PDLIM1/TWF2	117
GO:0009055	electron transfer activity	51/2130	126/18367	9.88610840650775e-17	3.57218050421813e-14	ASPH/GLDC/NDUFB9/ADH5/NDUFA10/CIAPIN1/NDUFB7/DEGS1/NDUFB2/COX6A1/NDUFS6/ETFA/CYB5A/NDUFB10/AKR1B1/NDUFA12/NDUFV2/NDUFC2/NDUFS7/COX5B/UQCR10/NDUFB4/COX7A2/UQCRFS1/NDUFS8/NDUFA4/UQCRC1/NDUFA1/NDUFB1/COX4I1/NDUFA5/AKR7A2/IDH3B/NDUFA3/POR/NDUFC1/AKR1A1/NDUFA2/NDUFS5/ETFB/COX5A/SURF1/NDUFA13/COX8A/NDUFS3/NDUFB8/QDPR/COX15/CYCS/UQCRH/CYC1	51
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	36/2130	72/18367	1.01723155431253e-15	2.75669751218694e-13	NDUFB9/NDUFA10/NDUFB7/NDUFB2/COX6A1/NDUFS6/CYB5A/NDUFB10/NDUFA12/NDUFV2/NDUFC2/NDUFS7/COX5B/UQCR10/NDUFB4/UQCRFS1/NDUFS8/NDUFA4/UQCRC1/NDUFA1/NDUFB1/COX4I1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/COX5A/SURF1/NDUFA13/COX8A/NDUFS3/NDUFB8/COX15/UQCRH/CYC1	36
GO:0019843	rRNA binding	34/2130	68/18367	6.35884772588097e-15	1.37859818697099e-12	IMP3/RPS18/MRPS7/RPS14/RPL37/MRPL20/RPL12/CIRBP/RPL11/RPL5/RPL23/RPS3/RPS5/MRPL11/MRPS6/RPS9/RPS4X/MRPL16/NPM1/RPS4Y1/RPL9/IMP4/BRIX1/DDX21/RPL19/EMG1/RPL23A/RPS13/RPLP0/UTP23/RPS11/EEF2/MDM2/RPL8	34
GO:0003712	transcription coregulator activity	109/2130	489/18367	8.23198336076453e-12	1.48724499384479e-09	SMARCA2/KCTD1/FUS/TLE4/CCAR1/MED7/SF1/MED23/MAGED1/PPP1R13L/USP22/TFAP2A/ARID5B/NRIP1/RSF1/CBX4/TCF25/NMI/TAF12/SND1/PAGE4/ARID3A/CEBPZ/MAML2/TRIM28/YAP1/PTPN14/MAML3/MED10/NCOA3/DNMT3A/TLE3/PRPF6/CCND1/BRD7/BRD4/GON4L/SRSF2/EID1/KDM5A/RLIM/FHL2/DMAP1/PARK7/SMARCA4/PHB/EDF1/TBL1X/ACTN4/HSBP1/RCOR1/KMT2C/C1QBP/SPEN/CTNNB1/NSD1/MTA3/DDX17/PHF10/VGLL1/TRIP11/RBFOX2/ENY2/CDYL/EWSR1/NPM1/NUPR1/TAF11/HNRNPU/NCOR1/MED29/SIN3B/TOB2/RBPMS/PFDN5/NUCKS1/HMGA1/BCLAF1/THRAP3/RERE/N4BP2L2/SMARCC1/MED30/PRMT2/UXT/IRF2BPL/TAF5L/JUP/PAWR/HSBP1L1/SUB1/ACTN1/MED12/ACTL6A/NOC2L/MED13/AIP/HMGB1/KDM5B/CNOT7/DNAJB1/NFKBIB/MED19/TACC1/CIR1/PDLIM1/TRIM27/DDX1/EID2	109
GO:0003954	NADH dehydrogenase activity	24/2130	45/18367	1.0179559609387e-11	1.57637751665364e-09	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/NDUFC2/AIFM1/NDUFS7/NDUFB4/NDUFS8/NDUFA4/NDUFA1/NDUFB1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8	24
GO:0008137	NADH dehydrogenase (ubiquinone) activity	23/2130	42/18367	1.32887469136739e-11	1.80062520680282e-09	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/NDUFC2/NDUFS7/NDUFB4/NDUFS8/NDUFA4/NDUFA1/NDUFB1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8	23
GO:0050136	NADH dehydrogenase (quinone) activity	23/2130	43/18367	2.54367925422917e-11	3.06372034620491e-09	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/NDUFC2/NDUFS7/NDUFB4/NDUFS8/NDUFA4/NDUFA1/NDUFB1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8	23
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	23/2130	45/18367	8.64168823230677e-11	9.36759004382054e-09	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/NDUFC2/NDUFS7/NDUFB4/NDUFS8/NDUFA4/NDUFA1/NDUFB1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8	23
GO:0045182	translation regulator activity	43/2130	140/18367	1.00679802464154e-09	9.92153689737659e-08	EIF3A/PURA/EIF2B5/IREB2/RPS14/EIF5B/ABCF1/EIF3G/CIRBP/EIF3E/DENR/RPL22/TUFM/RPL10/CYFIP1/EIF2AK2/EIF2D/RPS9/EIF3D/EIF4A1/PAIP1/EIF3L/EIF2AK4/EEF1D/HBS1L/GCN1/EIF3K/EIF4G2/EIF1AX/EIF2B2/IGF2BP3/EIF2S2/EEF2/EEF1A1/EEF1B2/SAMD4B/EIF3B/RPS27L/FXR1/EIF5A/EIF3F/EIF6/EIF4G1	43
GO:0051082	unfolded protein binding	39/2130	122/18367	1.66148714027318e-09	1.50087671671344e-07	ERLEC1/LMAN1/HSP90B1/HSPA5/ERO1B/AFG3L2/DNAJB6/PPIB/CALR/HSP90AA1/HSPA8/HSPA9/SERPINH1/NUDCD2/UGGT2/PFDN2/HSPD1/HSP90AB1/SIL1/PFDN1/CANX/PPIA/CCT4/CCDC115/HSPE1/SRSF10/NPM1/TOMM20/PFDN5/NACA/DNAJB11/GRPEL1/AIP/DNAJB1/CDC37/ST13/CCT5/PDRG1/MKKS	39
GO:0043021	ribonucleoprotein complex binding	44/2130	149/18367	2.5510817625732e-09	2.12720971586873e-07	RPN2/HSPA5/NEMF/CCDC47/SND1/TIMM50/DDX5/SRP54/PRPF6/NVL/ITCH/RPSA/C1QBP/RPLP1/DDX3X/SERBP1/LTN1/SNRPG/SEC61B/SNRPC/NAA10/RBM3/SRPRA/NPM1/HNRNPU/SNRPB2/CBX5/SRP72/CD2BP2/DERL2/GCN1/MALSU1/EIF3K/PYM1/EEF2/TMEM147/SNRPD2/SNRPB/PPIH/PPP1CA/MDM2/SRP68/EIF5A/EIF6	44
GO:0048027	mRNA 5'-UTR binding	16/2130	27/18367	3.76581900127677e-09	2.9158198552743e-07	MYH10/DHX36/RPS7/RPS14/RPL41/RPL5/DDX3X/RPL26/NCL/GNL3/SYNCRIP/IGF2BP3/RPS13/UTP23/RPS3A/CCT5	16
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	24/2130	57/18367	5.03105545412911e-09	3.63577607485064e-07	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/DCXR/NDUFC2/NDUFS7/NDUFB4/NDUFS8/NDUFA4/NDUFA1/NDUFB1/NDUFA5/NDUFA3/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8	24
GO:0003714	transcription corepressor activity	49/2130	187/18367	2.53129437678226e-08	1.71495194026998e-06	KCTD1/TLE4/CCAR1/SF1/PPP1R13L/TFAP2A/NRIP1/CBX4/TCF25/TRIM28/YAP1/DNMT3A/TLE3/CCND1/BRD7/GON4L/SRSF2/EID1/RLIM/FHL2/DMAP1/SMARCA4/PHB/TBL1X/HSBP1/RCOR1/C1QBP/SPEN/NSD1/MTA3/RBFOX2/CDYL/HNRNPU/NCOR1/SIN3B/TOB2/PFDN5/RERE/N4BP2L2/UXT/IRF2BPL/PAWR/HSBP1L1/NOC2L/KDM5B/CNOT7/DNAJB1/CIR1/EID2	49
GO:0008135	translation factor activity, RNA binding	28/2130	84/18367	1.18881654547406e-07	7.58045373702281e-06	EIF3A/EIF2B5/EIF5B/ABCF1/EIF3G/EIF3E/DENR/TUFM/EIF2D/EIF3D/EIF4A1/EIF3L/EEF1D/HBS1L/GCN1/EIF3K/EIF4G2/EIF1AX/EIF2B2/EIF2S2/EEF2/EEF1A1/EEF1B2/EIF3B/EIF5A/EIF3F/EIF6/EIF4G1	28
GO:0016651	oxidoreductase activity, acting on NAD(P)H	28/2130	88/18367	3.57020320193372e-07	2.15005570605342e-05	NDUFB9/NDUFA10/NDUFB7/NDUFB2/NDUFS6/NDUFB10/NDUFA12/NDUFV2/DCXR/NDUFC2/AIFM1/NDUFS7/NDUFB4/NDUFS8/NDUFA4/CYB5R1/NDUFA1/NDUFB1/NDUFA5/NDUFA3/POR/NDUFC1/NDUFA2/NDUFS5/NDUFA13/NDUFS3/NDUFB8/COX15	28
GO:0016853	isomerase activity	41/2130	158/18367	4.50513445419255e-07	2.57029776228669e-05	PDIA3/P4HB/GLCE/PDIA4/ISYNA1/ERO1B/PDIA6/FKBP2/PTGES2/PDIA5/PTGES/FKBP4/DEGS1/PPIB/PGM3/ECI1/PMM2/NKTR/ECH1/HSPD1/THAP4/GSTZ1/PPIE/PPIA/ENOPH1/TOP2B/DDT/IDI1/FKBP3/MIF/PIN4/PPIG/BPGM/ERP44/ECI2/PPIH/AIP/TPI1/RPIA/PIN1/PPIC	41
GO:0015399	primary active transmembrane transporter activity	45/2130	181/18367	4.7478364807965e-07	2.57332737259171e-05	ATP2B1/SLC26A2/NDUFB9/NDUFA10/NDUFB7/NDUFB2/COX6A1/NDUFS6/CYB5A/NDUFB10/NDUFA12/NDUFV2/NDUFC2/NDUFS7/COX5B/UQCR10/NDUFB4/UQCRFS1/NDUFS8/NDUFA4/UQCRC1/NDUFA1/NDUFB1/COX4I1/NDUFA5/NDUFA3/ABCB1/NDUFC1/TOMM20/NDUFA2/NDUFS5/COX5A/SURF1/ATP6V1C2/NDUFA13/ATP6V1G1/COX8A/NDUFS3/NDUFB8/ATP1A1/COX15/ATP13A3/UQCRH/CYC1/ATP6V0E1	45
GO:0140297	DNA-binding transcription factor binding	79/2130	394/18367	6.95941546902006e-07	3.59238398496083e-05	JUN/ISL1/FUS/TACC2/BHLHE41/TLE4/TRIM6/NFE2L2/CEBPA/HCLS1/NRIP1/COMMD7/TAF12/RBPJ/FOS/HMGN3/DDX5/PURA/YAP1/ID2/CALR/NCOA3/PRPF6/DDRGK1/TCF7L2/TRIP6/FHL2/DMAP1/PSMC5/PARK7/DCAF13/SMARCA4/TBX3/SP1/CHD4/PTPN2/PARP1/ACTN4/RPS3/COMMD6/YWHAZ/SPEN/HES1/CTNNB1/NSD1/RBFOX2/LYAR/PTMA/ETS2/JUND/NPM1/TAF11/NFKBIA/TDG/NCOR1/CBX5/CDK5RAP3/HSF1/CHCHD2/REST/TOB2/HMGA1/THRAP3/PPARG/MED30/PRMT2/CREM/MED12/NOC2L/MED13/AIP/CNOT1/HMGB1/CNOT7/TACC1/GABARAPL1/MAPK14/HSPB1/MKKS	79
GO:0090079	translation regulator activity, nucleic acid binding	31/2130	108/18367	1.09680026658579e-06	5.40423404081364e-05	EIF3A/PURA/EIF2B5/EIF5B/ABCF1/EIF3G/EIF3E/DENR/TUFM/EIF2D/EIF3D/EIF4A1/PAIP1/EIF3L/EEF1D/HBS1L/GCN1/EIF3K/EIF4G2/EIF1AX/EIF2B2/EIF2S2/EEF2/EEF1A1/EEF1B2/EIF3B/RPS27L/EIF5A/EIF3F/EIF6/EIF4G1	31
GO:0017070	U6 snRNA binding	10/2130	16/18367	1.78037153776322e-06	8.39096846493622e-05	LSM7/LARP7/LSM8/SART3/LSM2/LSM4/PRPF8/LSM3/PRPF4/EIF5A	10
GO:0003743	translation initiation factor activity	19/2130	51/18367	1.88832918514465e-06	8.52895348623667e-05	EIF3A/EIF2B5/EIF5B/EIF3G/EIF3E/DENR/EIF2D/EIF3D/EIF4A1/EIF3L/EIF3K/EIF4G2/EIF1AX/EIF2B2/EIF2S2/EIF3B/EIF3F/EIF6/EIF4G1	19
GO:0003713	transcription coactivator activity	56/2130	262/18367	3.87984560299953e-06	0.000168230105346059	SMARCA2/FUS/CCAR1/MED7/MED23/MAGED1/USP22/ARID5B/NRIP1/TAF12/PAGE4/CEBPZ/MAML2/TRIM28/YAP1/MAML3/NCOA3/PRPF6/BRD7/BRD4/KDM5A/PARK7/SMARCA4/EDF1/ACTN4/KMT2C/CTNNB1/MTA3/DDX17/VGLL1/TRIP11/ENY2/NPM1/NUPR1/TAF11/RBPMS/NUCKS1/HMGA1/THRAP3/RERE/SMARCC1/MED30/PRMT2/TAF5L/JUP/SUB1/ACTN1/MED12/ACTL6A/MED13/AIP/HMGB1/NFKBIB/TACC1/PDLIM1/TRIM27	56
GO:0098631	cell adhesion mediator activity	20/2130	59/18367	5.55371044749902e-06	0.000231547004811113	BCAM/DSG2/JAM3/TRIM29/DSP/DSC2/ITGB1/BAIAP2/CD47/KRT18/ANXA2/PALLD/S100A11/RPSA/ANXA1/CDC42EP1/JUP/PPP1CA/CNN3/PDLIM1	20
GO:0098641	cadherin binding involved in cell-cell adhesion	10/2130	18/18367	7.80451462045273e-06	0.000313336809206324	TRIM29/BAIAP2/KRT18/ANXA2/S100A11/ANXA1/CDC42EP1/PPP1CA/CNN3/PDLIM1	10
GO:0016860	intramolecular oxidoreductase activity	18/2130	51/18367	8.52506813865244e-06	0.000330041923653544	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PTGES2/PDIA5/PTGES/ECI1/ECH1/ENOPH1/DDT/IDI1/MIF/ERP44/ECI2/TPI1/RPIA	18
GO:0008022	protein C-terminus binding	43/2130	189/18367	9.92908645006594e-06	0.000371142403857637	DST/BCAM/FBLN1/SIAH1/PRRC2C/BAIAP2/ATXN2/SNX17/PPP1R9A/FOXN3/YAP1/VPS4B/ID1/XRCC5/SP1/PHB/TBL1X/EZR/RABAC1/CDK7/ERBB2/ITGB3BP/CTNNB1/NCL/TOP2B/XRCC6/YWHAB/POLR2A/SNF8/PPARG/EML2/DAB2/DYNLT1/DLG1/PRDX3/VPS4A/MED12/BANF1/VAMP2/PPP2CB/VPS36/DBNL/COIL	43
GO:0046966	thyroid hormone receptor binding	13/2130	30/18367	1.17111098253958e-05	0.000423161435024303	FUS/HMGN3/NCOA3/TRIP6/NSD1/TAF11/NCOR1/THRAP3/MED30/PRMT2/MED12/MED13/TACC1	13
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	60/2130	299/18367	1.4274201686432e-05	0.000499136600906202	JUN/ISL1/FUS/TACC2/BHLHE41/NFE2L2/CEBPA/HCLS1/NRIP1/COMMD7/RBPJ/FOS/HMGN3/DDX5/ID2/CALR/NCOA3/PRPF6/DDRGK1/TCF7L2/TRIP6/DMAP1/PARK7/DCAF13/SMARCA4/TBX3/SP1/CHD4/PTPN2/PARP1/ACTN4/COMMD6/SPEN/HES1/CTNNB1/NSD1/ETS2/JUND/NPM1/TAF11/NFKBIA/NCOR1/CDK5RAP3/HSF1/REST/TOB2/HMGA1/THRAP3/PPARG/MED30/PRMT2/MED12/MED13/AIP/CNOT1/TACC1/GABARAPL1/MAPK14/HSPB1/MKKS	60
GO:0017069	snRNA binding	18/2130	53/18367	1.57191639710539e-05	0.00053248667951945	LSM7/LARP7/LSM8/SART3/LSM2/HNRNPU/SNRPB2/SNRPD3/LSM4/DDX21/PRPF8/LSM3/SNRNP35/PRPF4/HEXIM1/SNRNP70/EIF5A/COIL	18
GO:0098632	cell-cell adhesion mediator activity	17/2130	49/18367	1.95842649120325e-05	0.000643313429231613	DSG2/JAM3/TRIM29/DSP/DSC2/BAIAP2/CD47/KRT18/ANXA2/PALLD/S100A11/ANXA1/CDC42EP1/JUP/PPP1CA/CNN3/PDLIM1	17
GO:0016859	cis-trans isomerase activity	15/2130	41/18367	2.92114487880373e-05	0.000931329720183308	FKBP2/FKBP4/DEGS1/PPIB/NKTR/GSTZ1/PPIE/PPIA/FKBP3/PIN4/PPIG/PPIH/AIP/PIN1/PPIC	15
GO:0044389	ubiquitin-like protein ligase binding	60/2130	316/18367	7.70851501158624e-05	0.00238743722073128	JUN/EGFR/HSPA5/TRIOBP/SHPRH/PSMD1/SLF2/CUL1/BAG5/TRAF4/RTN4/TRIM28/NAE1/CALR/HSP90AA1/HSPA8/DDRGK1/HM13/HSPA9/LRPPRC/XRCC5/SLC25A5/UBE2A/PSMA3/ITCH/RRAGA/RPS27A/NEDD8/HSPD1/RPL11/RPL5/HSP90AB1/YWHAE/CUL5/RPL23/FZD6/UQCRC1/YWHAZ/SUMO1/CRK/VCP/ABCB1/NFKBIA/ARRDC1/STUB1/POLR2A/CDK5RAP3/CACUL1/SUMO2/RNF8/HSPBP1/UBE2J2/ACTG1/SQSTM1/USP25/TPI1/UBE2N/ERBB3/MDM2/GABARAPL1	60
GO:0031625	ubiquitin protein ligase binding	57/2130	297/18367	8.50786400465159e-05	0.00256181238362287	JUN/EGFR/HSPA5/TRIOBP/SHPRH/PSMD1/SLF2/CUL1/BAG5/TRAF4/RTN4/TRIM28/NAE1/CALR/HSP90AA1/HSPA8/HM13/HSPA9/LRPPRC/XRCC5/SLC25A5/UBE2A/PSMA3/RRAGA/RPS27A/NEDD8/HSPD1/RPL11/RPL5/HSP90AB1/YWHAE/CUL5/RPL23/FZD6/UQCRC1/YWHAZ/SUMO1/CRK/VCP/ABCB1/NFKBIA/ARRDC1/STUB1/POLR2A/CACUL1/SUMO2/RNF8/HSPBP1/UBE2J2/ACTG1/SQSTM1/USP25/TPI1/UBE2N/ERBB3/MDM2/GABARAPL1	57
GO:0044183	protein folding chaperone	14/2130	40/18367	9.41402847777716e-05	0.00275805591078661	HSPA5/CCDC47/DNAJB6/CALR/HSPA8/HSPA9/PFDN2/HSP90AB1/PFDN1/CCT4/WDR83OS/DNAJB1/CCT5/HSPB1	14
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	17/2130	55/18367	0.000104152667888352	0.00297109189449931	GPX8/HBA1/MGST3/HBA2/PTGES/PRDX4/GSTP1/PRDX5/PARK7/PRDX1/GSTZ1/TXNDC17/HBG2/GSTK1/HBB/HBG1/PRDX3	17
GO:0008143	poly(A) binding	10/2130	23/18367	0.000117880645704087	0.00327647743444179	HNRNPDL/KHDRBS1/PPIE/PABPC4/DDX3X/HNRNPU/RBPMS/RBMS1/RBMS2/DDX1	10
GO:0004601	peroxidase activity	16/2130	51/18367	0.000135779200247568	0.00367961632670908	GPX8/HBA1/MGST3/HBA2/PTGES/PRDX4/GSTP1/PRDX5/PRDX1/GSTZ1/TXNDC17/HBG2/GSTK1/HBB/HBG1/PRDX3	16
GO:0140104	molecular carrier activity	20/2130	73/18367	0.000172472550550908	0.00456000597066303	KPNB1/HBA1/HBA2/NDUFAB1/EMC10/HSPA8/PARK7/EMC1/EMC6/HBG2/EMC8/HBB/SCO1/EMC7/HBG1/CSE1L/ATOX1/NUTF2/KPNA6/RAN	20
GO:0016675	oxidoreductase activity, acting on a heme group of donors	9/2130	20/18367	0.000189038726452216	0.00487899951129053	COX6A1/CYB5A/COX5B/COX4I1/POR/COX5A/SURF1/COX8A/COX15	9
GO:0005178	integrin binding	32/2130	144/18367	0.000204967156863861	0.00504964541000966	LAMA5/ITGB4/FBN1/ITGB8/EGFR/LAMB1/UTRN/DST/PLPP3/JAM3/FBLN1/ITGAV/P4HB/FERMT2/ITGB1/ITGB5/CD81/FERMT1/CALR/MMP14/PTPN2/ACTN4/TSPAN4/LGALS8/PPIA/S1PR2/NISCH/CD151/ACTN1/TLN1/HMGB1/EMP2	32
GO:0016922	nuclear receptor binding	32/2130	144/18367	0.000204967156863861	0.00504964541000966	ISL1/FUS/TACC2/NRIP1/HMGN3/DDX5/CALR/NCOA3/PRPF6/TCF7L2/TRIP6/PARK7/DCAF13/SMARCA4/PARP1/ACTN4/CTNNB1/NSD1/ETS2/JUND/TAF11/NCOR1/TOB2/HMGA1/THRAP3/PPARG/MED30/PRMT2/MED12/MED13/CNOT1/TACC1	32
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	13/2130	38/18367	0.000216731517224931	0.00522082143715167	FKBP2/FKBP4/PPIB/NKTR/PPIE/PPIA/FKBP3/PIN4/PPIG/PPIH/AIP/PIN1/PPIC	13
GO:0003727	single-stranded RNA binding	22/2130	87/18367	0.000295414770161168	0.00696151327945014	L1TD1/HNRNPDL/CBX4/KHDRBS1/MSI2/PPIE/PABPC4/DDX3X/STRBP/SNRPC/ENDOV/ANXA1/HNRNPU/HNRNPF/RBPMS/HNRNPA1/RBMS1/SSB/HMGB1/RBMS2/FXR1/DDX1	22
GO:0004298	threonine-type endopeptidase activity	7/2130	14/18367	0.000456781184488931	0.0103156417497084	PSMB2/PSMB6/PSMB1/PSMA4/PSMB5/PSMB3/PSMB4	7
GO:0044548	S100 protein binding	7/2130	14/18367	0.000456781184488931	0.0103156417497084	AHNAK/IQGAP1/ANXA2/S100A11/EZR/S100A6/ANXA11	7
GO:0051020	GTPase binding	53/2130	291/18367	0.000558982482857619	0.0123660614575032	SYTL1/IQGAP2/CHM/RASA1/IQGAP1/RHOBTB3/TRIOBP/MYCBP2/KPNB1/AIMP1/IPO7/PPP1R9A/RAB11FIP1/CDC42BPB/SPTBN1/CLTA/HSP90AA1/EVI5/INF2/ANXA2/GOLGA4/EPS8/YIPF1/IFT20/ATP6AP1/CHML/EXPH5/RAC1/CYFIP1/ERRFI1/ROCK1/FNBP1L/RANGRF/SOD1/RANBP2/TRIP11/LSM2/ENO1/RRAGC/RAB3GAP1/DVL3/PFN1/RABGAP1/FMNL2/CSE1L/GDI2/NUTF2/PKN2/CCDC186/RAB3GAP2/RAB11FIP4/DIAPH2/AP3M1	53
GO:0030515	snoRNA binding	11/2130	32/18367	0.000627723529775417	0.013609046125531	PRKDC/NHP2/NOP58/IMP3/BMS1/XRCC5/GAR1/IMP4/DDX21/NOP10/NUDT5	11
GO:0004129	cytochrome-c oxidase activity	8/2130	19/18367	0.000748503704686807	0.0159093728604019	COX6A1/CYB5A/COX5B/COX4I1/COX5A/SURF1/COX8A/COX15	8
GO:0060090	molecular adaptor activity	63/2130	369/18367	0.00104147126249725	0.0217106701643657	COL14A1/SYNE2/ANK3/DLG5/IQGAP1/EPB41L3/NCSTN/TRIM6/BAIAP2/KHDRBS1/WWC2/FKBP4/CUX1/GOSR1/VAMP8/PDE4DIP/SLC9A1/HSPA8/LAMTOR4/PSMC6/EPS8/OBSL1/LDLRAP1/SUN1/RAD50/NCK1/BLNK/PDCD6/SEC22B/ABI1/PSMG2/CAV2/SHC1/AP1M2/CRK/DDB1/AKAP9/CDYL/HOMER1/AP1S1/MPP7/ARRDC1/STUB1/CBX5/PTPN11/HERPUD1/STX16/JUP/DAB2/COX15/AP1S3/DLG1/VAMP2/CNOT1/SPAG9/AP2S1/EIF3B/APH1A/LAMTOR5/ST13/AP2M1/EIF4G1/STX7	63
GO:0070717	poly-purine tract binding	10/2130	29/18367	0.00107310751377772	0.0219480857534915	HNRNPDL/KHDRBS1/PPIE/PABPC4/DDX3X/HNRNPU/RBPMS/RBMS1/RBMS2/DDX1	10
GO:0043022	ribosome binding	17/2130	66/18367	0.00111009069885379	0.0222840429177316	RPN2/HSPA5/CCDC47/RPSA/C1QBP/SERBP1/SEC61B/NAA10/SRP72/GCN1/EIF3K/PYM1/EEF2/TMEM147/SRP68/EIF5A/EIF6	17
GO:0022804	active transmembrane transporter activity	68/2130	406/18367	0.00113771017716113	0.0224232333098666	ATP2B1/SLC16A12/SLC26A2/SLC38A2/SLC12A9/SLC19A1/SLC1A3/SLC22A11/SLC6A4/NDUFB9/SLC16A2/SLC38A1/SLC25A4/NDUFA10/NDUFB7/SLC20A2/SLC12A4/NDUFB2/COX6A1/NDUFS6/SLC13A4/CYB5A/SLC9A1/SLC7A6/NDUFB10/SLC35C2/NDUFA12/NDUFV2/NDUFC2/SLC25A3/NDUFS7/COX5B/SLC25A5/UQCR10/NDUFB4/UQCRFS1/NDUFS8/SLC35D2/NDUFA4/UQCRC1/NDUFA1/NDUFB1/COX4I1/NDUFA5/SLC35E3/NDUFA3/ABCB1/NDUFC1/TOMM20/NDUFA2/NDUFS5/SLC10A3/COX5A/SURF1/SLC25A6/ATP6V1C2/NDUFA13/ATP6V1G1/COX8A/NDUFS3/NDUFB8/ATP1A1/COX15/SLC16A4/ATP13A3/UQCRH/CYC1/ATP6V0E1	68
GO:0042826	histone deacetylase binding	27/2130	127/18367	0.00126085231521352	0.0244064983873474	BHLHE41/MAGEA10/NRIP1/GLI3/NACC1/DHX36/HSP90AA1/CCND1/SP1/PHB/CHD4/HSP90AB1/YWHAE/PARP1/RAC1/HES1/MTA3/NUDT21/TOP2B/YWHAB/NCOR1/GCM1/RFXANK/MAGEA8/PKN2/CIR1/SFPQ	27
GO:0003924	GTPase activity	58/2130	337/18367	0.0013270534977224	0.0252372980970365	RASA1/RHOB/RHOBTB3/GNA12/ARHGAP5/RHOBTB1/GNAI1/SAR1A/ARF5/RAB40C/GNL1/RAB31/RAB12/GNG5/LSG1/SRP54/RAB14/GNAI2/GNAQ/IFT27/EIF5B/RAB17/GNAS/BMS1/RRAGA/RASL11B/RAB21/GPN3/TUFM/KRAS/RAC1/GNA11/DDX3X/ARL5B/RAB2A/ARL1/RAB38/MTG2/RAB25/RAB6A/MRAS/SRPRA/RHOC/RHOU/RRAGC/ARL2/HBS1L/ARL15/ARF6/ARL5A/EEF2/EEF1A1/RAB1A/RND3/RAN/RAB5C/DNM2/RAB7A	58
GO:0030674	protein-macromolecule adaptor activity	52/2130	296/18367	0.00144916508530936	0.0270843957323336	COL14A1/SYNE2/ANK3/DLG5/IQGAP1/EPB41L3/NCSTN/TRIM6/BAIAP2/KHDRBS1/FKBP4/CUX1/GOSR1/VAMP8/SLC9A1/HSPA8/PSMC6/EPS8/OBSL1/LDLRAP1/SUN1/RAD50/NCK1/BLNK/PDCD6/SEC22B/ABI1/CAV2/SHC1/AP1M2/CRK/DDB1/CDYL/HOMER1/AP1S1/MPP7/ARRDC1/STUB1/CBX5/PTPN11/HERPUD1/STX16/JUP/DAB2/AP1S3/VAMP2/SPAG9/AP2S1/APH1A/ST13/AP2M1/STX7	52
GO:0016209	antioxidant activity	20/2130	86/18367	0.0016778824808546	0.0308275357499387	GPX8/SOD3/HBA1/MGST3/HBA2/PTGES/PRDX4/GSTP1/PRDX5/TXNRD2/PARK7/PRDX1/GSTZ1/TXNDC17/SOD1/HBG2/GSTK1/HBB/HBG1/PRDX3	20
GO:0005525	GTP binding	63/2130	377/18367	0.00178877174429934	0.031503576287697	RHOB/RHOBTB3/GNA12/ARHGAP5/RHOBTB1/GNAI1/SAR1A/ARF5/RAB40C/GNL1/RAB31/RAB12/TGM2/LSG1/SRP54/RAB14/GNAI2/GNAQ/IFT27/EIF5B/RAB17/GNAS/BMS1/RRAGA/RASL11B/RAB21/HSP90AB1/GPN3/TUFM/KRAS/RAC1/GNA11/ARL5B/GNL3/RAB2A/ARL1/RAB38/MTG2/RAB25/RAB6A/MRAS/SRPRA/RHOC/RHOU/RRAGC/ARL2/DAP3/AK3/HBS1L/RTCB/EIF2B2/ARL15/ARF6/ARL5A/EEF2/EEF1A1/GLUD1/RAB1A/RND3/RAN/RAB5C/DNM2/RAB7A	63
GO:0008094	ATP-dependent activity, acting on DNA	24/2130	111/18367	0.00179736179141497	0.031503576287697	SMARCA2/SHPRH/MCM3/DHX36/BPTF/NAV2/ATAD5/XRCC5/SMARCA4/RAD50/CHD4/G3BP1/RAD17/SMARCA5/CDK7/SMC3/DDX3X/TOP2B/XRCC6/ANXA1/ASCC3/CHD6/ATRX/DDX1	24
GO:0004386	helicase activity	31/2130	156/18367	0.00183712698269396	0.031503576287697	SMARCA2/SHPRH/MCM3/DDX50/DDX24/DDX5/DHX36/DICER1/NAV2/XRCC5/SMARCA4/RAD50/CHD4/G3BP1/SMARCA5/DDX3X/DDX17/XRCC6/DDX18/EIF4A1/ANXA1/DDX21/DDX52/ASCC3/DDX42/CHD6/DDX56/ATRX/DDX46/DDX1/HELZ	31
GO:0042974	retinoic acid receptor binding	9/2130	26/18367	0.0018415325254086	0.031503576287697	FUS/NRIP1/ACTN4/NSD1/HMGA1/PPARG/PRMT2/CNOT1/TACC1	9
GO:0097718	disordered domain specific binding	11/2130	36/18367	0.00188734141567326	0.031503576287697	GJA5/GJA1/CLTC/NCOA3/HSP90AA1/HSP90AB1/EZR/CTNNB1/CALM1/MDM2/AP2M1	11
GO:0070064	proline-rich region binding	7/2130	17/18367	0.00188905208367187	0.031503576287697	BAIAP2/GAREM1/YAP1/CCND1/RABAC1/PFN1/NEDD4	7
GO:0019003	GDP binding	18/2130	75/18367	0.0019258802782568	0.0316311245701571	RHOB/GNAI1/RAB40C/RAB31/RAB12/SRP54/RAB14/RAB17/RAB21/KRAS/RAB2A/MRAS/RRAGC/ARL2/ARF6/RAN/RAB5C/RAB7A	18
GO:0002039	p53 binding	16/2130	66/18367	0.00300886860040706	0.0485602271693411	TRIM29/USP10/CDK5/SMYD2/BRD7/BRD4/PTTG1IP/SMARCA4/HSPD1/PSME3/TAF3/MDM4/TRIAP1/EEF2/MDM2/EHMT1	16
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	6/2130	14/18367	0.00317125892925386	0.0485602271693411	ECI1/ECH1/DDT/IDI1/MIF/ECI2	6
GO:0043023	ribosomal large subunit binding	6/2130	14/18367	0.00317125892925386	0.0485602271693411	NEMF/LTN1/RBM3/NPM1/MALSU1/EIF6	6
GO:0004300	enoyl-CoA hydratase activity	5/2130	10/18367	0.00318060528507677	0.0485602271693411	HADHA/ECHS1/ECI1/ECHDC2/HADHB	5
GO:0031720	haptoglobin binding	5/2130	10/18367	0.00318060528507677	0.0485602271693411	HBA1/HBA2/HBG2/HBB/HBG1	5
GO:0042393	histone binding	43/2130	244/18367	0.00334094785325249	0.0502998260128569	SMARCA2/MORC4/BAZ1B/CTSL/MPHOSPH8/RSF1/CBX4/IPO7/MTF2/NASP/SPIN1/BPTF/BRD7/BRD4/SUPT6H/KDM5A/SUZ12/SMARCA4/ING3/MLLT6/RBBP7/TBL1X/SMARCA5/SET/KMT2C/PWP1/PHF10/SART3/NAP1L1/CDYL/NPM1/CBX5/SBNO1/KMT2A/DEK/SNCA/RNF8/SMARCC1/PIH1D1/TSPYL1/NOC2L/KDM5B/ATRX	43
GO:0032182	ubiquitin-like protein binding	23/2130	111/18367	0.00390961059032353	0.057407911402331	CBX4/FAAP20/CUEDC2/NSFL1C/UBE2A/UBR5/UCHL3/SERBP1/TDG/RNF8/MVB12A/PELP1/RBCK1/RAD23B/SQSTM1/USP25/N4BP2/UBE2N/NEDD4/MDM2/VPS36/HSPB1/BUB3	23
GO:0003746	translation elongation factor activity	7/2130	19/18367	0.00397194958964467	0.057407911402331	TUFM/EEF1D/HBS1L/EEF2/EEF1A1/EEF1B2/EIF5A	7
GO:0035615	clathrin adaptor activity	7/2130	19/18367	0.00397194958964467	0.057407911402331	LDLRAP1/AP1M2/AP1S1/DAB2/AP1S3/AP2S1/AP2M1	7
GO:0003725	double-stranded RNA binding	17/2130	74/18367	0.0041303209173764	0.0580962949743142	TLR3/DHX36/CLTC/DICER1/STAU1/LRRFIP1/HSPD1/HSP90AB1/EIF2AK2/STRBP/EIF4A1/HNRNPU/DDX21/ILF2/ACTN1/HMGB1/DDX1	17
GO:0019001	guanyl nucleotide binding	64/2130	398/18367	0.00418036070848386	0.0580962949743142	SLC19A1/RHOB/RHOBTB3/GNA12/ARHGAP5/RHOBTB1/GNAI1/SAR1A/ARF5/RAB40C/GNL1/RAB31/RAB12/TGM2/LSG1/SRP54/RAB14/GNAI2/GNAQ/IFT27/EIF5B/RAB17/GNAS/BMS1/RRAGA/RASL11B/RAB21/HSP90AB1/GPN3/TUFM/KRAS/RAC1/GNA11/ARL5B/GNL3/RAB2A/ARL1/RAB38/MTG2/RAB25/RAB6A/MRAS/SRPRA/RHOC/RHOU/RRAGC/ARL2/DAP3/AK3/HBS1L/RTCB/EIF2B2/ARL15/ARF6/ARL5A/EEF2/EEF1A1/GLUD1/RAB1A/RND3/RAN/RAB5C/DNM2/RAB7A	64
GO:0032561	guanyl ribonucleotide binding	64/2130	398/18367	0.00418036070848386	0.0580962949743142	SLC19A1/RHOB/RHOBTB3/GNA12/ARHGAP5/RHOBTB1/GNAI1/SAR1A/ARF5/RAB40C/GNL1/RAB31/RAB12/TGM2/LSG1/SRP54/RAB14/GNAI2/GNAQ/IFT27/EIF5B/RAB17/GNAS/BMS1/RRAGA/RASL11B/RAB21/HSP90AB1/GPN3/TUFM/KRAS/RAC1/GNA11/ARL5B/GNL3/RAB2A/ARL1/RAB38/MTG2/RAB25/RAB6A/MRAS/SRPRA/RHOC/RHOU/RRAGC/ARL2/DAP3/AK3/HBS1L/RTCB/EIF2B2/ARL15/ARF6/ARL5A/EEF2/EEF1A1/GLUD1/RAB1A/RND3/RAN/RAB5C/DNM2/RAB7A	64
GO:0070003	threonine-type peptidase activity	8/2130	24/18367	0.00428493822572397	0.058795861223858	GGT7/PSMB2/PSMB6/PSMB1/PSMA4/PSMB5/PSMB3/PSMB4	8
GO:0042809	vitamin D receptor binding	6/2130	15/18367	0.00477147903204503	0.0646535408842102	TAF11/TOB2/THRAP3/MED30/MED12/MED13	6
GO:0051087	chaperone binding	22/2130	107/18367	0.00518231463700075	0.0678339809053935	LRP2/GRN/DNAJC1/HSPA5/CTSC/ERP29/BAG5/DNAJB6/CALR/HSPA8/SDF2L1/TIMM44/HSPD1/HES1/SOD1/HSPE1/STUB1/ATP1A1/GRPEL1/DNAJB1/CDC37/ST13	22
GO:0000774	adenyl-nucleotide exchange factor activity	5/2130	11/18367	0.00527756786768889	0.0678339809053935	BAG5/SIL1/PFN1/HSPBP1/GRPEL1	5
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	5/2130	11/18367	0.00527756786768889	0.0678339809053935	DSG2/DSP/DSC2/CD47/JUP	5
GO:0097371	MDM2/MDM4 family protein binding	5/2130	11/18367	0.00527756786768889	0.0678339809053935	RPL37/RPS15/CDK5RAP3/PSME3/RPS20	5
GO:0003756	protein disulfide isomerase activity	7/2130	20/18367	0.00550681763807622	0.0678339809053935	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PDIA5/ERP44	7
GO:0016018	cyclosporin A binding	7/2130	20/18367	0.00550681763807622	0.0678339809053935	PPIB/NKTR/PPIE/PPIA/PPIG/PPIH/PPIC	7
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	7/2130	20/18367	0.00550681763807622	0.0678339809053935	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PDIA5/ERP44	7
GO:0140312	cargo adaptor activity	7/2130	20/18367	0.00550681763807622	0.0678339809053935	LDLRAP1/AP1M2/AP1S1/DAB2/AP1S3/AP2S1/AP2M1	7
GO:0051117	ATPase binding	19/2130	89/18367	0.00592135344485601	0.0721207543171227	EGFR/NCSTN/RDX/NOP58/SDF2L1/NSFL1C/EZR/TMEM106B/RAC1/PSEN1/UBE4B/ATP6V1G1/PELP1/PIH1D1/ATOX1/USP25/DNAJB1/CHMP4A/TOR1AIP2	19
GO:0031267	small GTPase binding	44/2130	259/18367	0.00600019632405021	0.0722690312807826	SYTL1/IQGAP2/CHM/IQGAP1/RHOBTB3/TRIOBP/MYCBP2/KPNB1/IPO7/RAB11FIP1/CDC42BPB/EVI5/INF2/ANXA2/GOLGA4/EPS8/YIPF1/IFT20/ATP6AP1/CHML/EXPH5/RAC1/CYFIP1/ERRFI1/ROCK1/RANGRF/SOD1/RANBP2/TRIP11/LSM2/RAB3GAP1/DVL3/PFN1/RABGAP1/FMNL2/CSE1L/GDI2/NUTF2/PKN2/CCDC186/RAB3GAP2/RAB11FIP4/DIAPH2/AP3M1	44
GO:0051015	actin filament binding	38/2130	217/18367	0.00617566725829645	0.0735650912966302	SPTAN1/EGFR/UTRN/SYNE2/IQGAP2/IQGAP1/SLC6A4/MYH10/TRIOBP/SCIN/FERMT2/HCLS1/ARPC1B/PSTPIP2/PPP1R9A/FERMT1/SPTBN1/LIMA1/ADD3/TPM4/MAP1S/CAPZB/ARPC5L/ARPC2/EZR/ACTN4/CYFIP1/SVIL/ARPC5/MACF1/CTTN/FMNL2/EEF2/DSTN/ACTN1/TLN1/DBNL/TWF2	38
GO:0017166	vinculin binding	5/2130	12/18367	0.00819131966906291	0.0965151143615673	UTRN/DAG1/RTCB/ACTN1/TLN1	5
GO:0016504	peptidase activator activity	11/2130	43/18367	0.00844887913145912	0.0984794083709858	APP/FBLN1/PCOLCE2/CTSC/VCP/PSME3/CTSH/BAD/RPS27L/APH1A/PSME1	11
GO:0043130	ubiquitin binding	19/2130	92/18367	0.00854221689137379	0.0985081181941403	FAAP20/CUEDC2/NSFL1C/UBE2A/UBR5/UCHL3/RNF8/MVB12A/RBCK1/RAD23B/SQSTM1/USP25/N4BP2/UBE2N/NEDD4/MDM2/VPS36/HSPB1/BUB3	19
GO:0097110	scaffold protein binding	15/2130	67/18367	0.0087311191769535	0.099626665134922	DSP/PSAP/BAIAP2/KRT18/HSP90AA1/PARK7/YWHAE/CAV2/IL6ST/CRK/XRCC6/DYNLL2/KRT8/UBTF/CDC37	15
GO:0004197	cysteine-type endopeptidase activity	23/2130	119/18367	0.009349364906735	0.105569912071883	PDIA3/CTSC/LGMN/CTSL/CTSF/USP10/CFLAR/CTSV/USP40/CTSD/CASP4/SENP7/USP48/CAPN1/CASP2/ATG4C/CTSH/USP47/USP8/SENP6/USP9X/USP34/USP25	23
GO:0046965	retinoid X receptor binding	6/2130	17/18367	0.0096239760487472	0.106452959559612	FUS/NRIP1/NSD1/HMGA1/PPARG/TACC1	6
GO:0050780	dopamine receptor binding	6/2130	17/18367	0.0096239760487472	0.106452959559612	GNA12/GNAS/PTPN11/SNX5/VPS35/DNM2	6
GO:0055106	ubiquitin-protein transferase regulator activity	7/2130	22/18367	0.00984616482317462	0.106732426683213	RPS7/RPL37/RPS15/RPL11/RPL5/RPL23/RPS20	7
GO:0070034	telomerase RNA binding	7/2130	22/18367	0.00984616482317462	0.106732426683213	NHP2/DHX36/HNRNPU/GAR1/SNRPD3/NOP10/SNRPB	7
GO:0050840	extracellular matrix binding	13/2130	56/18367	0.0103846829213013	0.111455408779115	BCAM/DAG1/ITGA6/ADGRG1/ITGAV/BGN/TINAGL1/ITGB1/GPC1/SMOC1/ANXA2/RPSA/LGALS3	13
GO:0031369	translation initiation factor binding	9/2130	33/18367	0.0107715261997562	0.114473866671919	EIF2B5/RPS24/NCK1/DDX3X/POLR2D/EIF2S2/EIF3B/EIF3F/EIF4G1	9
GO:0051219	phosphoprotein binding	18/2130	88/18367	0.0113638558643376	0.119596308319825	RASA1/CBX4/RRAGA/LDLRAP1/YWHAE/SHC1/CRK/YWHAB/PTPN11/PRKCSH/SNCA/PFN1/THRAP3/PIH1D1/RTF1/NEDD4/PIN1/LEO1	18
GO:0003779	actin binding	67/2130	440/18367	0.0118852000914732	0.119950059089037	SPTAN1/EGFR/UTRN/DST/SYNE2/IQGAP2/PLEC/DAG1/P4HB/IQGAP1/SLC6A4/MYH10/EPB41L3/TRIOBP/SCIN/FERMT2/ITGB1/HCLS1/PHACTR2/ARPC1B/CALD1/PSTPIP2/PPP1R9A/FERMT1/RAI14/RDX/SPTBN1/WASL/LIMA1/INF2/ADD3/PALLD/TPM4/EPS8/MAP1S/CAP1/CAPZB/ARPC5L/ARPC2/EZR/ACTN4/CYFIP1/MSRB2/TMSB10/SVIL/HNRNPU/ARPC5/MACF1/COBLL1/CTTN/SNCA/PFN1/EPS8L2/TRPM7/FMNL2/EEF2/DSTN/PAWR/ACTN1/TLN1/ALDOA/VASP/DBNL/DIAPH2/CNN3/PDLIM1/TWF2	67
GO:0043236	laminin binding	8/2130	28/18367	0.0118899812091727	0.119950059089037	BCAM/DAG1/ITGA6/TINAGL1/ITGB1/GPC1/RPSA/LGALS3	8
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5/2130	13/18367	0.0120559498845056	0.119950059089037	DUSP6/DUSP9/DUSP14/DUSP5/DUSP1	5
GO:0031994	insulin-like growth factor I binding	5/2130	13/18367	0.0120559498845056	0.119950059089037	LRP2/ITGB4/ITGA6/ITGAV/IGF1R	5
GO:0060590	ATPase regulator activity	5/2130	13/18367	0.0120559498845056	0.119950059089037	BAG5/SIL1/PFN1/HSPBP1/GRPEL1	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	13/2130	57/18367	0.0120613989305397	0.119950059089037	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PDIA5/TXNRD2/TMX1/TXNDC17/MSRB2/PCYOX1/TXNDC12/PRDX3	13
GO:0001618	virus receptor activity	16/2130	76/18367	0.012545007352037	0.123544590401651	EGFR/CD46/DAG1/ITGAV/ITGB1/SLC52A1/ITGB5/IDE/CD81/SLC20A2/SIVA1/SLC52A2/DPP4/RPSA/CD55/LAMP1	16
GO:0005158	insulin receptor binding	7/2130	23/18367	0.0127647547278459	0.123544590401651	IGF1R/SHC1/SNX4/PTPN11/PDPK1/PTPN1/SNX2	7
GO:0017134	fibroblast growth factor binding	7/2130	23/18367	0.0127647547278459	0.123544590401651	ITGAV/GPC1/TGFBR3/GLG1/RPS19/RPS2/CEP57	7
GO:0140597	protein carrier activity	6/2130	18/18367	0.0130437819413171	0.125127961277767	EMC10/HSPA8/EMC1/EMC6/EMC8/EMC7	6
GO:0004177	aminopeptidase activity	10/2130	40/18367	0.0138887827292268	0.132065267355104	ENPEP/MMP15/CTSV/DPP4/NPEPPS/MMP14/NPEPL1/RNPEP/CTSH/METAP2	10
GO:0140272	exogenous protein binding	16/2130	77/18367	0.0141786307458219	0.13364900633453	EGFR/CD46/DAG1/ITGAV/ITGB1/SLC52A1/ITGB5/IDE/CD81/SLC20A2/SIVA1/SLC52A2/DPP4/RPSA/CD55/LAMP1	16
GO:0047485	protein N-terminus binding	21/2130	110/18367	0.014437355251012	0.134914595621526	SRRM2/RPS21/RBPJ/NCOA3/ID1/SMARCA4/EIF3E/PARP1/VPS25/NPM1/TAF11/SNF8/SNCA/SMARCC1/ARF6/PELP1/CALM1/BANF1/MORF4L1/MDM2/EIF5A	21
GO:0051787	misfolded protein binding	8/2130	29/18367	0.0147885673628147	0.13701544462642	HSPA5/HSPA8/SDF2L1/HSPA9/SDF2/STUB1/DERL2/DNAJB11	8
GO:0001221	transcription coregulator binding	16/2130	78/18367	0.0159729859243749	0.146734887644257	NFE2L2/EPAS1/BAIAP2/VGLL4/MTF2/TFAM/SUZ12/SMARCA4/SP1/CHD4/RPL23/UBE2I/CTNNB1/CBX3/CHD6/EHMT1	16
GO:0019789	SUMO transferase activity	7/2130	24/18367	0.0162564438757784	0.147353664045068	CBX4/TRIM28/UBE2I/RANBP2/SUMO2/MDM2/TRIM27	7
GO:0030331	estrogen receptor binding	10/2130	41/18367	0.0165102102842693	0.147353664045068	ISL1/FUS/NRIP1/DCAF13/PARP1/CTNNB1/NSD1/PRMT2/CNOT1/TACC1	10
GO:0048487	beta-tubulin binding	10/2130	41/18367	0.0165102102842693	0.147353664045068	LRPPRC/MAP1S/ADNP/SMC3/EML4/PDCD5/SNCA/UXT/GABARAPL1/CCT5	10
GO:0005344	oxygen carrier activity	5/2130	14/18367	0.0169918893040899	0.147353664045068	HBA1/HBA2/HBG2/HBB/HBG1	5
GO:0008474	palmitoyl-(protein) hydrolase activity	5/2130	14/18367	0.0169918893040899	0.147353664045068	ABHD12/ABHD17A/LYPLA1/LYPLA2/LYPLAL1	5
GO:0032977	membrane insertase activity	5/2130	14/18367	0.0169918893040899	0.147353664045068	EMC10/EMC1/EMC6/EMC8/EMC7	5
GO:0098599	palmitoyl hydrolase activity	5/2130	14/18367	0.0169918893040899	0.147353664045068	ABHD12/ABHD17A/LYPLA1/LYPLA2/LYPLAL1	5
GO:0016835	carbon-oxygen lyase activity	16/2130	79/18367	0.0179377788921502	0.153106711173943	HACD3/ACO2/HADHA/ECHS1/IREB2/ECI1/ECHDC2/XRCC5/HADHB/CA8/PARK7/RPS3/XRCC6/ENO1/CDYL/TPI1	16
GO:0046332	SMAD binding	16/2130	79/18367	0.0179377788921502	0.153106711173943	JUN/FERMT2/IPO7/FOS/DDX5/PURA/TGFBR3/YY1/PARP1/CTNNB1/STUB1/PPARG/TGIF1/DAB2/USP9X/EID2	16
GO:0044325	transmembrane transporter binding	24/2130	133/18367	0.0182812347513528	0.154819206800519	TCAF1/ANK3/USP10/PPP1R9A/ID2/GPD1L/HSP90AB1/YWHAE/ACTN4/YWHAZ/S100A10/RANGRF/CTNNB1/AKAP9/HOMER1/VDAC1/PRKCSH/HERPUD1/GOPC/DLG1/CALM1/ACTN1/VAMP2/AP2M1	24
GO:0015036	disulfide oxidoreductase activity	10/2130	42/18367	0.0194803705982319	0.163695517275065	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PDIA5/TXNRD2/TMX1/TXNDC17/TXNDC12	10
GO:0019838	growth factor binding	25/2130	141/18367	0.0199733703715623	0.166547180636719	NRP2/LRP2/ITGB4/EGFR/COL4A1/ITGA6/ITGAV/IGF1R/CRIM1/GPC1/FLT1/TGFBR3/GLG1/LTBP1/RPS19/LIFR/NRP1/ERBB2/SHC1/RPS2/IL6ST/SEC61B/CEP57/ERBB3/DUSP1	25
GO:0034237	protein kinase A regulatory subunit binding	7/2130	25/18367	0.0203731967136978	0.167307160891276	AKAP1/EZR/AKAP9/ARFGEF2/ACBD3/ARFGEF1/PRRC1	7
GO:0051019	mitogen-activated protein kinase binding	7/2130	25/18367	0.0203731967136978	0.167307160891276	IQGAP1/TAB1/TPR/CDK5RAP3/PRMT1/MAPK14/DUSP1	7
GO:0005507	copper ion binding	13/2130	61/18367	0.0209296379948199	0.169668963111308	F5/SOD3/GPC1/P2RX4/CUTA/SNCG/PARK7/ADNP/SOD1/RNF7/SNCA/SCO1/ATOX1	13
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	4/2130	10/18367	0.0212868809807545	0.169668963111308	PTPN12/PTPN2/PTPN11/DUSP22	4
GO:0008097	5S rRNA binding	4/2130	10/18367	0.0212868809807545	0.169668963111308	RPL11/RPL5/EEF2/MDM2	4
GO:0008330	protein tyrosine/threonine phosphatase activity	4/2130	10/18367	0.0212868809807545	0.169668963111308	DUSP6/DUSP9/DUSP5/DUSP1	4
GO:0140678	molecular function inhibitor activity	23/2130	128/18367	0.0215249355264813	0.170314088399312	RASA1/PURA/ID2/ID1/ANXA2/RPS7/ANXA5/RPL37/RPS15/RPL11/RPL5/RPL23/LYAR/ANXA3/ANXA1/TAF3/PPP1R12A/MDFI/HSPBP1/CALM1/RNH1/NEDD4/RPS20	23
GO:0005080	protein kinase C binding	12/2130	55/18367	0.021774330004021	0.171038940031586	ITGAV/DSP/SRSF2/PARD6B/C1QBP/HINT1/TOP2B/PRKCSH/YWHAG/SQSTM1/HSPB1/TWF2	12
GO:0140318	protein transporter activity	8/2130	31/18367	0.0220643405561344	0.17207010908525	LRP2/IGF1R/TOMM7/ATAD1/TIMM8B/SEC61G/TOMM20/TMED10	8
GO:0031683	G-protein beta/gamma-subunit complex binding	6/2130	20/18367	0.0222553374240284	0.172319898340334	GNA12/GNAI1/GNAI2/GNAQ/GNAS/GNA11	6
GO:0015035	protein-disulfide reductase activity	9/2130	37/18367	0.0227721008275114	0.175070619127818	PDIA3/P4HB/PDIA4/ERO1B/PDIA6/PDIA5/TXNRD2/TXNDC17/TXNDC12	9
GO:0048306	calcium-dependent protein binding	17/2130	88/18367	0.0233000458556234	0.177488038610091	DDX5/SLC9A1/ANXA2/S100A11/SEC31A/CPNE3/PDCD6/S100A10/ANXA3/S100A6/CLN3/ANXA1/PDCD6IP/ANXA11/S100P/CALM1/VAMP2	17
GO:0031072	heat shock protein binding	23/2130	129/18367	0.0234140124734714	0.177488038610091	HSPA5/KPNB1/BAG5/CDK5/FKBP4/TFAM/DNAJB6/HSPA8/HSPA9/TOMM34/HSP90AB1/LMAN2/RPS3/TPR/DNAJB14/DNAJC7/STUB1/HSF1/SNCA/DNAJC8/DNAJB1/CDC37/ST13	23
GO:0030374	nuclear receptor coactivator activity	12/2130	56/18367	0.0248805973902173	0.184729914869833	CCAR1/USP22/NCOA3/ACTN4/ENY2/HMGA1/THRAP3/MED30/ACTN1/MED12/MED13/TACC1	12
GO:0045309	protein phosphorylated amino acid binding	12/2130	56/18367	0.0248805973902173	0.184729914869833	RASA1/LDLRAP1/YWHAE/SHC1/CRK/YWHAB/PTPN11/PFN1/RTF1/NEDD4/PIN1/LEO1	12
GO:0051287	NAD binding	12/2130	56/18367	0.0248805973902173	0.184729914869833	IDH1/HADHA/GPD1L/PARP1/IDH3B/HIBADH/IDH2/IDH3G/GRHPR/MDH1/QDPR/GLUD1	12
GO:0005048	signal sequence binding	11/2130	50/18367	0.0258495103846743	0.189330197682344	KPNB1/SRP54/SRP14/KDELR2/KDELR1/NFKBIA/TOMM20/NUP58/KPNA6/SRP68/AP2M1	11
GO:0015932	nucleobase-containing compound transmembrane transporter activity	11/2130	50/18367	0.0258495103846743	0.189330197682344	SLC19A1/SLC25A36/SLC29A3/SLC25A4/SLC35B4/SLC25A5/SLC35D2/HNRNPA3/SLC35E3/SLC35A2/SLC25A6	11
GO:0140416	transcription regulator inhibitor activity	6/2130	21/18367	0.0281791666383413	0.203641444239747	PURA/ID2/ID1/LYAR/TAF3/MDFI	6
GO:1990381	ubiquitin-specific protease binding	6/2130	21/18367	0.0281791666383413	0.203641444239747	CLTC/PARK7/SUMO1/SART3/VCP/DERL2	6
GO:0004857	enzyme inhibitor activity	14/2130	70/18367	0.0284484231437812	0.20422576614476	ANXA2/RPS7/ANXA5/RPL37/RPS15/RPL11/RPL5/RPL23/ANXA3/ANXA1/PPP1R12A/HSPBP1/RNH1/RPS20	14
GO:0003724	RNA helicase activity	15/2130	77/18367	0.029695773164609	0.210749218554909	DDX50/DDX24/DDX5/DHX36/G3BP1/DDX3X/DDX17/DDX18/EIF4A1/DDX21/DDX52/DDX42/DDX56/DDX46/DDX1	15
GO:0046975	histone methyltransferase activity (H3-K36 specific)	4/2130	11/18367	0.0304350599025062	0.210749218554909	SETD5/SMYD2/ASH1L/NSD1	4
GO:0097493	structural molecule activity conferring elasticity	4/2130	11/18367	0.0304350599025062	0.210749218554909	FBN2/FBN1/LAMC1/AHNAK	4
GO:0005159	insulin-like growth factor receptor binding	5/2130	16/18367	0.0304694087835258	0.210749218554909	GNAS/SOCS1/SHC1/CRK/YWHAG	5
GO:0032183	SUMO binding	5/2130	16/18367	0.0304694087835258	0.210749218554909	CBX4/SERBP1/TDG/PELP1/USP25	5
GO:0070006	metalloaminopeptidase activity	7/2130	27/18367	0.0306690102264738	0.210749218554909	ENPEP/MMP15/NPEPPS/MMP14/NPEPL1/RNPEP/METAP2	7
GO:0048156	tau protein binding	10/2130	45/18367	0.0307180595310661	0.210749218554909	LGMN/CDK5/FKBP4/HSP90AA1/HSP90AB1/ROCK1/STUB1/SNCA/PPP2CB/PIN1	10
GO:0031491	nucleosome binding	14/2130	71/18367	0.0317850974851903	0.216698400465071	HP1BP3/HMGN3/ACTR6/SUPT6H/SMARCA4/MLLT6/CHD4/SMARCA5/SMARCC1/HMGN1/ACTL6A/NOC2L/SUPT16H/ZNHIT1	14
GO:0000062	fatty-acyl-CoA binding	6/2130	22/18367	0.0350540423190289	0.234559147369305	ACADVL/HADHA/DBI/ACBD6/ACBD3/ECI2	6
GO:0004602	glutathione peroxidase activity	6/2130	22/18367	0.0350540423190289	0.234559147369305	GPX8/MGST3/PTGES/GSTP1/GSTZ1/GSTK1	6
GO:0008093	cytoskeletal anchor activity	6/2130	22/18367	0.0350540423190289	0.234559147369305	ANK3/EPB41L3/BAIAP2/OBSL1/NCK1/JUP	6
GO:0000049	tRNA binding	14/2130	72/18367	0.0353972538543271	0.235402596184605	IARS2/NEMF/TRMT11/AIMP1/NAT10/DTD1/TYW5/RPL35A/ELP5/EIF2AK4/HSD17B10/EEF1A1/SSB/TRMT10A	14
GO:0008186	ATP-dependent activity, acting on RNA	15/2130	79/18367	0.0364846639054699	0.23970476788672	DDX50/DDX24/DDX5/DHX36/G3BP1/DDX3X/DDX17/DDX18/EIF4A1/DDX21/DDX52/DDX42/DDX56/DDX46/DDX1	15
GO:0008187	poly-pyrimidine tract binding	7/2130	28/18367	0.0369286865655741	0.23970476788672	KHDRBS1/MSI2/PABPC4/HNRNPU/RBMS1/SSB/RBMS2	7
GO:0050681	androgen receptor binding	7/2130	28/18367	0.0369286865655741	0.23970476788672	DDX5/CALR/PRPF6/PARK7/SMARCA4/NSD1/PRMT2	7
GO:0070325	lipoprotein particle receptor binding	7/2130	28/18367	0.0369286865655741	0.23970476788672	LRP1/HSP90B1/LRPAP1/SNX17/CLTC/LDLRAP1/AP2M1	7
GO:0070063	RNA polymerase binding	14/2130	73/18367	0.0392954733442598	0.249600992442253	WDR43/PPIB/SMYD2/NCOA3/PABPN1/BRD4/ERBB2/WAC/HNRNPU/RTF1/PKN2/PAF1/NEDD4/LEO1	14
GO:0106306	protein serine phosphatase activity	14/2130	73/18367	0.0392954733442598	0.249600992442253	DUSP6/DUSP9/CTDSPL/DUSP14/CPPED1/PTPMT1/PHLPP2/PPM1G/DUSP5/DUSP22/PPP2CB/PPP1CA/PPP4C/DUSP1	14
GO:0106307	protein threonine phosphatase activity	14/2130	73/18367	0.0392954733442598	0.249600992442253	DUSP6/DUSP9/CTDSPL/DUSP14/CPPED1/PTPMT1/PHLPP2/PPM1G/DUSP5/DUSP22/PPP2CB/PPP1CA/PPP4C/DUSP1	14
GO:0140677	molecular function activator activity	25/2130	150/18367	0.0393743262985472	0.249600992442253	DNAJC1/DPM3/PSAP/TAB1/CFLAR/DDOST/MMP15/GM2A/DNAJB6/GNAS/XRCC5/PARK7/SUZ12/ARL1/PDCD5/DNAJC7/NUPR1/KRTCAP2/PDPK1/DNAJC19/CALM1/DNAJB1/RAB3GAP2/DBNL/TOR1AIP2	25
GO:0003995	acyl-CoA dehydrogenase activity	4/2130	12/18367	0.0415569300192279	0.257415497947675	ACADVL/ACADS/TECR/IVD	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4/2130	12/18367	0.0415569300192279	0.257415497947675	SLC35B4/SLC35D2/SLC35E3/SLC35A2	4
GO:0042975	peroxisome proliferator activated receptor binding	4/2130	12/18367	0.0415569300192279	0.257415497947675	HMGA1/PRMT2/MDM2/TACC1	4
GO:0097677	STAT family protein binding	4/2130	12/18367	0.0415569300192279	0.257415497947675	CEBPA/PTPN2/HSF1/PPARG	4
GO:0050750	low-density lipoprotein particle receptor binding	6/2130	23/18367	0.0429208497041523	0.262859893103396	HSP90B1/LRPAP1/SNX17/CLTC/LDLRAP1/AP2M1	6
GO:1901567	fatty acid derivative binding	6/2130	23/18367	0.0429208497041523	0.262859893103396	ACADVL/HADHA/DBI/ACBD6/ACBD3/ECI2	6
GO:0004725	protein tyrosine phosphatase activity	18/2130	102/18367	0.0451800877367567	0.275141657902496	PTP4A1/PTPRM/DUSP6/DUSP9/TIMM50/PTPN14/DUSP14/PTPRF/PTPMT1/PTPN12/PTPN2/PGP/PTPRE/PTPN11/PTPN1/DUSP5/DUSP22/DUSP1	18
GO:0051536	iron-sulfur cluster binding	13/2130	68/18367	0.0469280770014121	0.28261130816406	ACO2/CIAPIN1/IREB2/NDUFV2/CISD1/NDUFS7/UQCRFS1/NDUFS8/RPS3/PPAT/NFU1/NUBP2/PRIM2	13
GO:0051540	metal cluster binding	13/2130	68/18367	0.0469280770014121	0.28261130816406	ACO2/CIAPIN1/IREB2/NDUFV2/CISD1/NDUFS7/UQCRFS1/NDUFS8/RPS3/PPAT/NFU1/NUBP2/PRIM2	13
GO:0051539	4 iron, 4 sulfur cluster binding	9/2130	42/18367	0.0483621275065816	0.289638376890245	ACO2/CIAPIN1/IREB2/NDUFS7/NDUFS8/PPAT/NFU1/NUBP2/PRIM2	9
GO:0008047	enzyme activator activity	19/2130	110/18367	0.0487880649930561	0.290583859628971	DPM3/PSAP/TAB1/CFLAR/DDOST/MMP15/GM2A/GNAS/XRCC5/PARK7/SUZ12/ARL1/PDCD5/NUPR1/KRTCAP2/PDPK1/CALM1/RAB3GAP2/DBNL	19
GO:0033549	MAP kinase phosphatase activity	5/2130	18/18367	0.0491977841467474	0.291422939973083	DUSP6/DUSP9/DUSP14/DUSP5/DUSP1	5
GO:0042162	telomeric DNA binding	8/2130	36/18367	0.0504632501183741	0.297294364827812	PURA/UPF2/XRCC5/UPF3A/RAD50/NCL/XRCC6/HNRNPA1	8
GO:0004859	phospholipase inhibitor activity	4/2130	13/18367	0.0546684767457711	0.316901758248213	ANXA2/ANXA5/ANXA3/ANXA1	4
GO:0031386	protein tag	4/2130	13/18367	0.0546684767457711	0.316901758248213	RPS27A/NEDD8/SUMO1/SUMO2	4
GO:0034450	ubiquitin-ubiquitin ligase activity	4/2130	13/18367	0.0546684767457711	0.316901758248213	UBR5/ANAPC11/UBE4B/STUB1	4
GO:1990782	protein tyrosine kinase binding	18/2130	105/18367	0.0574749667513077	0.331398212544774	TRIM6/ITGB1/KHDRBS1/EIF3A/PTPN14/HSP90AA1/NEDD9/CPNE3/NCK1/BLNK/PTPN2/SHC1/CRK/PTPN11/PTPN1/DUSP22/YWHAG/SQSTM1	18
GO:0033218	amide binding	57/2130	400/18367	0.0582004619354939	0.333805824010981	ENPEP/DHCR24/LRP1/LRPAP1/MME/SLC19A1/ITM2C/IGF1R/PSAP/IDE/KPNB1/FKBP2/CST3/PTGES2/ACADVL/CTSV/PTGES/FKBP4/PPIB/ITM2B/CLTA/HADHA/CALR/SRP54/FOLR1/DBI/NKTR/SRP14/NPEPPS/KDELR2/LDLRAP1/ADNP/PFDN2/HSP90AB1/PPIE/PFDN1/KDELR1/PPIA/PRLR/VDAC2/ACBD6/NFKBIA/FKBP3/VDAC1/TOMM20/PFDN5/NUP58/PPIG/GLTP/ACBD3/PPARG/ECI2/PPIH/KPNA6/SRP68/AP2M1/PPIC	57
GO:0090482	vitamin transmembrane transporter activity	7/2130	31/18367	0.0605081141592593	0.344011490882623	SLC19A1/SLC52A1/SLC19A3/SLC52A3/SLC52A2/SLC2A8/SLC2A1	7
GO:0000339	RNA cap binding	5/2130	19/18367	0.0606145708104991	0.344011490882623	NCBP3/CYFIP1/EIF3D/EIF4A1/DCPS	5
GO:0008266	poly(U) RNA binding	6/2130	25/18367	0.0617360760118281	0.346745628999076	KHDRBS1/MSI2/PABPC4/RBMS1/SSB/RBMS2	6
GO:0120227	acyl-CoA binding	6/2130	25/18367	0.0617360760118281	0.346745628999076	ACADVL/HADHA/DBI/ACBD6/ACBD3/ECI2	6
GO:0016836	hydro-lyase activity	12/2130	64/18367	0.0621369885046941	0.347198430613858	HACD3/ACO2/HADHA/ECHS1/IREB2/ECI1/ECHDC2/HADHB/CA8/PARK7/ENO1/CDYL	12
GO:0008013	beta-catenin binding	15/2130	85/18367	0.0634332081214606	0.352623577454684	CDH1/DLG5/GJA1/GLI3/TCF7L2/TBL1X/CTNNB1/PSEN1/KANK1/CTNNBIP1/DVL3/CBY1/MED12/NUMB/PIN1	15
GO:0005543	phospholipid binding	65/2130	466/18367	0.0653706791575911	0.361539878606269	IQGAP2/SYT7/ZFYVE16/MME/IQGAP1/PSD4/CPNE8/SCIN/EPN2/FERMT2/MYOF/PSAP/EEA1/SNX17/KRIT1/PHLDA2/WDR45B/PARD3/SPTBN1/CYTH3/PEBP1/SNX14/SLC9A1/SGK3/HSPA8/ANXA2/EXOC1/ANXA5/CHMP2A/NSFL1C/CPNE3/LDLRAP1/PLA2G15/PHLDA3/SH3YL1/PLEKHA5/SHC1/NF1/ARHGAP32/SNX6/SNX4/PLEKHF2/ANXA3/GSDMD/SVIL/VDAC2/ANXA1/VDAC1/NISCH/SNCA/PFN1/GLTP/RASA2/ANXA11/BAD/PLEKHF1/PXDC1/SNX5/TLN1/VAMP2/HMGB1/SNX2/VPS36/TWF2/SNX27	65
GO:1901981	phosphatidylinositol phosphate binding	27/2130	173/18367	0.0665752393421321	0.366332789070412	IQGAP2/SYT7/ZFYVE16/IQGAP1/SCIN/FERMT2/KRIT1/PHLDA2/WDR45B/PARD3/CYTH3/SNX14/SLC9A1/ANXA2/EXOC1/LDLRAP1/PHLDA3/PLEKHA5/ARHGAP32/GSDMD/SVIL/PFN1/PLEKHF1/SNX5/VPS36/TWF2/SNX27	27
GO:0016829	lyase activity	30/2130	196/18367	0.0684465925323205	0.373932213946205	GLDC/APMAP/HACD3/GGCX/ACO2/MGST3/RNASET2/PTGES2/PDXDC1/HADHA/ECHS1/IREB2/ECI1/ECHDC2/XRCC5/HADHB/CA8/PARK7/PISD/ILVBL/RPS3/GGCT/XRCC6/ENO1/DDT/CDYL/UMPS/ALDOA/HMGB1/TPI1	30
GO:0003678	DNA helicase activity	13/2130	72/18367	0.0690854567680357	0.373932213946205	MCM3/DHX36/NAV2/XRCC5/RAD50/CHD4/G3BP1/DDX3X/XRCC6/ANXA1/ASCC3/CHD6/ATRX	13
GO:0030276	clathrin binding	13/2130	72/18367	0.0690854567680357	0.373932213946205	LRP1/SYT7/EPN2/CLTA/CLTC/NSG1/LDLRAP1/AP1M2/AP1S1/DAB2/AP1S3/AP2S1/AP2M1	13
GO:0015926	glucosidase activity	4/2130	14/18367	0.0697391117224437	0.373932213946205	GAA/AGL/MOGS/GANAB	4
GO:0071837	HMG box domain binding	4/2130	14/18367	0.0697391117224437	0.373932213946205	JUN/DLX5/SP1/GATA3	4
GO:0140658	ATP-dependent chromatin remodeler activity	7/2130	32/18367	0.0700260511356824	0.373932213946205	SMARCA2/SHPRH/SMARCA4/CHD4/SMARCA5/CHD6/ATRX	7
GO:0004721	phosphoprotein phosphatase activity	27/2130	174/18367	0.0704619664609029	0.374415547272641	PTP4A1/PTPRM/DUSP6/DUSP9/CTDSPL/TIMM50/PTPN14/DUSP14/CPPED1/PTPRF/PTPMT1/PTPN12/PTPN2/PGP/PHLPP2/PPM1G/PTPRE/CAMK2G/PTPN11/PTPN1/DUSP5/DUSP22/DLG1/PPP2CB/PPP1CA/PPP4C/DUSP1	27
GO:0015078	proton transmembrane transporter activity	21/2130	130/18367	0.072620250052838	0.384001712474519	SLC25A4/COX6A1/CYB5A/SLC9A1/SLC25A3/COX5B/SLC25A5/UQCR10/UQCRFS1/UQCRC1/COX4I1/COX5A/SURF1/ATP6V1C2/ATP6V1G1/COX8A/COX15/UQCRH/ATP6V1B1/CYC1/ATP6V0E1	21
GO:0003697	single-stranded DNA binding	20/2130	123/18367	0.0742095443205587	0.387594611136754	MCM3/PURA/REXO4/DHX36/LRPPRC/RAD50/HSPD1/SSBP1/ANXA1/HNRNPU/HSF1/NUCKS1/PCBP1/HNRNPA1/RAD23B/RBMS1/SUB1/RTF1/HMGB1/SMC2	20
GO:0008234	cysteine-type peptidase activity	29/2130	190/18367	0.0742825833123684	0.387594611136754	PDIA3/CTSC/LGMN/CTSL/CTSF/USP10/USP22/CFLAR/OTULIN/USP27X/CTSV/USP40/CTSD/CASP4/SENP7/USP48/UCHL3/CAPN1/CASP2/SCRN2/ATG4C/CTSH/USP47/USP8/SENP6/USP9X/USP34/USP25/EIF3F	29
GO:0140030	modification-dependent protein binding	25/2130	160/18367	0.0743723977088974	0.387594611136754	MORC4/AGL/MPHOSPH8/IDE/CBX4/MTF2/FAAP20/SPIN1/BPTF/BRD7/BRD4/KDM5A/SUZ12/SMARCA4/ING3/HSPD1/PWP1/CDYL/VCP/CBX5/KMT2A/PRPF8/RAD23B/SQSTM1/ATRX	25
GO:0035064	methylated histone binding	13/2130	73/18367	0.0755399531765204	0.389930044015943	MORC4/MPHOSPH8/CBX4/MTF2/SPIN1/BPTF/KDM5A/SUZ12/ING3/PWP1/CDYL/CBX5/ATRX	13
GO:0140034	methylation-dependent protein binding	13/2130	73/18367	0.0755399531765204	0.389930044015943	MORC4/MPHOSPH8/CBX4/MTF2/SPIN1/BPTF/KDM5A/SUZ12/ING3/PWP1/CDYL/CBX5/ATRX	13
GO:0000287	magnesium ion binding	33/2130	221/18367	0.0767405560777863	0.394250060608153	IDH1/GNAI1/COMT/CDC42BPB/DHX36/EPHX2/PGM3/STK26/PDCD6/ILVBL/TKT/MAST4/PGP/RNASEH1/ENOPH1/PPA1/ENO1/IDH3B/MTG2/IDH2/ENDOV/RRAGC/IDH3G/ATP10D/TDG/SNCA/STK3/S100P/STK38/SRPK2/RAN/WEE1/NUDT5	33
GO:0140097	catalytic activity, acting on DNA	34/2130	229/18367	0.0780770823405413	0.399224326684655	SMARCA2/SHPRH/MCM3/DHX36/DNMT1/DNMT3A/BPTF/DICER1/NAV2/ATAD5/XRCC5/MPG/SMARCA4/RAD50/CHD4/G3BP1/RAD17/SMARCA5/CDK7/SMC3/RPS3/DDX3X/TOP2B/XRCC6/APEX2/ENDOV/ANXA1/TDG/ASCC3/XRCC1/CHD6/ATRX/PLD3/DDX1	34
GO:0035591	signaling adaptor activity	14/2130	81/18367	0.0818133110444563	0.416364456207468	DLG5/IQGAP1/KHDRBS1/EPS8/LDLRAP1/NCK1/BLNK/ABI1/SHC1/CRK/HOMER1/MPP7/PTPN11/SPAG9	14
GO:0001671	ATPase activator activity	6/2130	27/18367	0.0847191345480842	0.425164545602422	DNAJC1/DNAJB6/DNAJC7/DNAJC19/DNAJB1/TOR1AIP2	6
GO:0004190	aspartic-type endopeptidase activity	6/2130	27/18367	0.0847191345480842	0.425164545602422	NCSTN/SPPL2B/CTSD/HM13/SPPL2A/PSEN1	6
GO:0023026	MHC class II protein complex binding	6/2130	27/18367	0.0847191345480842	0.425164545602422	CD81/HSP90AA1/HSPA8/HSP90AB1/YWHAE/ANXA11	6
GO:0001846	opsonin binding	4/2130	15/18367	0.0866980270978367	0.429135440064178	ITGAV/CALR/PHB/C1QBP	4
GO:0015929	hexosaminidase activity	4/2130	15/18367	0.0866980270978367	0.429135440064178	NAGLU/HEXA/GM2A/HEXB	4
GO:0098847	sequence-specific single stranded DNA binding	4/2130	15/18367	0.0866980270978367	0.429135440064178	RAD50/HSF1/PCBP1/HNRNPA1	4
GO:0016887	ATP hydrolysis activity	39/2130	272/18367	0.0947996594680817	0.456554943608043	ATP2B1/HSPA5/RHOBTB3/MCM3/DDX50/DDX24/DDX5/KIF1C/DHX36/VPS4B/HSP90AA1/HSPA8/NAV2/NVL/HSPA9/HSPD1/CHD4/G3BP1/SMARCA5/DDX3X/ATAD1/DDX17/DDX18/VCP/KIF5B/EIF4A1/ATP10D/DDX21/DDX52/ASCC3/DDX42/ATP1A1/VPS4A/CHD6/ATP13A3/DDX56/ATRX/DDX46/DDX1	39
GO:0046875	ephrin receptor binding	6/2130	28/18367	0.0977528930887688	0.456554943608043	EFNA1/CDK5/NCK1/SHC1/CRK/PTPN1	6
GO:0070001	aspartic-type peptidase activity	6/2130	28/18367	0.0977528930887688	0.456554943608043	NCSTN/SPPL2B/CTSD/HM13/SPPL2A/PSEN1	6
GO:0004722	protein serine/threonine phosphatase activity	16/2130	98/18367	0.09919277993695	0.456554943608043	DUSP6/DUSP9/CTDSPL/TIMM50/DUSP14/CPPED1/PTPMT1/PHLPP2/PPM1G/CAMK2G/DUSP5/DUSP22/PPP2CB/PPP1CA/PPP4C/DUSP1	16
GO:0005522	profilin binding	3/2130	10/18367	0.100239923043094	0.456554943608043	CTTN/ACTG1/VASP	3
GO:0005528	FK506 binding	3/2130	10/18367	0.100239923043094	0.456554943608043	FKBP2/FKBP4/FKBP3	3
GO:0008172	S-methyltransferase activity	3/2130	10/18367	0.100239923043094	0.456554943608043	MTR/DNMT3A/KMT2A	3
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	3/2130	10/18367	0.100239923043094	0.456554943608043	SLC35B4/SLC35D2/SLC35A2	3
GO:0015643	toxic substance binding	3/2130	10/18367	0.100239923043094	0.456554943608043	EPHX2/ASS1/PHAX	3
GO:0015924	mannosyl-oligosaccharide mannosidase activity	3/2130	10/18367	0.100239923043094	0.456554943608043	MAN2A1/EDEM2/MAN1A2	3
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	3/2130	10/18367	0.100239923043094	0.456554943608043	CYB5R1/POR/COX15	3
GO:0016803	ether hydrolase activity	3/2130	10/18367	0.100239923043094	0.456554943608043	EPHX2/AKR7A2/RNPEP	3
GO:0016868	intramolecular transferase activity, phosphotransferases	3/2130	10/18367	0.100239923043094	0.456554943608043	PGM3/PMM2/BPGM	3
GO:0030957	Tat protein binding	3/2130	10/18367	0.100239923043094	0.456554943608043	SMARCA4/NPM1/GABARAPL1	3
GO:0034511	U3 snoRNA binding	3/2130	10/18367	0.100239923043094	0.456554943608043	PRKDC/BMS1/XRCC5	3
GO:0045294	alpha-catenin binding	3/2130	10/18367	0.100239923043094	0.456554943608043	CTNNB1/JUP/NUMB	3
GO:0046974	histone methyltransferase activity (H3-K9 specific)	3/2130	10/18367	0.100239923043094	0.456554943608043	SETD5/ASH1L/EHMT1	3
GO:0070016	armadillo repeat domain binding	3/2130	10/18367	0.100239923043094	0.456554943608043	TCF7L2/CTNNBIP1/CNOT1	3
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	3/2130	10/18367	0.100239923043094	0.456554943608043	CFLAR/CASP4/CASP2	3
GO:0070182	DNA polymerase binding	5/2130	22/18367	0.102967727721424	0.467016806903864	NAT10/HSP90AA1/SMARCA4/HSP90AB1/HMGB1	5
GO:0015923	mannosidase activity	4/2130	16/18367	0.105440899869274	0.476241397742887	MAN2A1/MANBA/EDEM2/MAN1A2	4
GO:0001046	core promoter sequence-specific DNA binding	8/2130	42/18367	0.106742122800784	0.478134136843179	FOS/KLF10/SMARCA4/NPM1/REST/UBTF/TAF1B/PIH1D1	8
GO:0019205	nucleobase-containing compound kinase activity	8/2130	42/18367	0.106742122800784	0.478134136843179	CLP1/ADK/AK6/AK3/DLG1/N4BP2/CMPK1/DGUOK	8
GO:0042054	histone methyltransferase activity	10/2130	56/18367	0.108372941246907	0.483441433381262	SETD5/SMYD2/ASH1L/SUZ12/KMT2C/NSD1/KMT2A/PRMT2/PRMT1/EHMT1	10
GO:1902936	phosphatidylinositol bisphosphate binding	17/2130	107/18367	0.110588441887527	0.491302750024916	SYT7/SCIN/KRIT1/WDR45B/PARD3/SNX14/SLC9A1/ANXA2/EXOC1/LDLRAP1/PHLDA3/PLEKHA5/GSDMD/SVIL/PFN1/SNX5/TWF2	17
GO:0050660	flavin adenine dinucleotide binding	14/2130	85/18367	0.111196509416448	0.491987821254815	DHCR24/ERO1B/ACADVL/ETFA/SQLE/AIFM1/ACADS/TXNRD2/D2HGDH/ILVBL/CYB5R1/POR/IVD/DUS1L	14
GO:0005520	insulin-like growth factor binding	6/2130	29/18367	0.111782359994986	0.492569423717742	LRP2/ITGB4/ITGA6/ITGAV/IGF1R/CRIM1	6
GO:0043175	RNA polymerase core enzyme binding	10/2130	57/18367	0.118523126044103	0.518791196034229	WDR43/SMYD2/NCOA3/BRD4/ERBB2/WAC/HNRNPU/RTF1/PAF1/LEO1	10
GO:0000993	RNA polymerase II complex binding	9/2130	50/18367	0.119059091033125	0.518791196034229	WDR43/SMYD2/NCOA3/BRD4/WAC/HNRNPU/RTF1/PAF1/LEO1	9
GO:0070412	R-SMAD binding	5/2130	23/18367	0.119647416059555	0.518791196034229	JUN/FOS/DDX5/PARP1/PPARG	5
GO:0140103	catalytic activity, acting on a glycoprotein	5/2130	23/18367	0.119647416059555	0.518791196034229	FUT8/B3GNT3/MGAT3/C1GALT1C1/C1GALT1	5
GO:0035091	phosphatidylinositol binding	38/2130	271/18367	0.124253503202008	0.5230372268907	IQGAP2/SYT7/ZFYVE16/IQGAP1/SCIN/FERMT2/EEA1/SNX17/KRIT1/PHLDA2/WDR45B/PARD3/CYTH3/SNX14/SLC9A1/SGK3/ANXA2/EXOC1/LDLRAP1/PHLDA3/SH3YL1/PLEKHA5/ARHGAP32/SNX6/SNX4/PLEKHF2/GSDMD/SVIL/NISCH/PFN1/PLEKHF1/PXDC1/SNX5/TLN1/SNX2/VPS36/TWF2/SNX27	38
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	15/2130	94/18367	0.12457880704871	0.5230372268907	NAGLU/HEXA/GAA/AGL/GM2A/FUCA1/HEXB/MAN2A1/MANBA/GUSB/MOGS/GANAB/EDEM2/MAN1A2/GLB1	15
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	19/2130	124/18367	0.124956071181627	0.5230372268907	IDH1/ADH5/HADHA/LDHB/AKR1B1/HSD17B1/DCXR/HADHB/KDSR/AKR7A2/IDH3B/HIBADH/IDH2/MDH2/IDH3G/GRHPR/AKR1A1/MDH1/HSD17B10	19
GO:0031489	myosin V binding	4/2130	17/18367	0.125836559596327	0.5230372268907	FUS/RAB14/RAB25/RAB6A	4
GO:0005347	ATP transmembrane transporter activity	3/2130	11/18367	0.126416746720815	0.5230372268907	SLC25A4/SLC25A5/SLC25A6	3
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	3/2130	11/18367	0.126416746720815	0.5230372268907	P4HB/ERO1B/PCYOX1	3
GO:0016801	hydrolase activity, acting on ether bonds	3/2130	11/18367	0.126416746720815	0.5230372268907	EPHX2/AKR7A2/RNPEP	3
GO:0031996	thioesterase binding	3/2130	11/18367	0.126416746720815	0.5230372268907	TRAF4/RAC1/ARF6	3
GO:0043560	insulin receptor substrate binding	3/2130	11/18367	0.126416746720815	0.5230372268907	IGF1R/PRKCZ/PTPN11	3
GO:0099186	structural constituent of postsynapse	3/2130	11/18367	0.126416746720815	0.5230372268907	ACTG1/DLG1/ACTN1	3
GO:1990226	histone methyltransferase binding	3/2130	11/18367	0.126416746720815	0.5230372268907	HSP90AB1/CTNNB1/CBX3	3
GO:1990459	transferrin receptor binding	3/2130	11/18367	0.126416746720815	0.5230372268907	CD81/SNX4/SNX2	3
GO:0051018	protein kinase A binding	9/2130	51/18367	0.130550222524284	0.538085327818722	AKAP1/RDX/EZR/RPS3/AKAP9/ARFGEF2/ACBD3/ARFGEF1/PRRC1	9
GO:0008238	exopeptidase activity	16/2130	103/18367	0.13731784847868	0.558238217546279	ENPEP/MME/NAALADL2/CTSC/MMP15/CTSV/CPVL/DPP4/NPEPPS/MMP14/NPEPL1/CPQ/SCRN2/RNPEP/CTSH/METAP2	16
GO:0004622	lysophospholipase activity	5/2130	24/18367	0.137499634764628	0.558238217546279	ABHD12/PLA2G15/LYPLA1/LYPLA2/LYPLAL1	5
GO:0043274	phospholipase binding	5/2130	24/18367	0.137499634764628	0.558238217546279	PRKCZ/BLNK/PTPN11/SNCA/PDPK1	5
GO:0043495	protein-membrane adaptor activity	5/2130	24/18367	0.137499634764628	0.558238217546279	SYNE2/EPB41L3/SUN1/PDCD6/JUP	5
GO:0019902	phosphatase binding	28/2130	196/18367	0.142905492737297	0.578020724355337	EGFR/HSP90B1/SH2D4A/IQGAP1/MET/ANAPC5/CTSC/KCNN4/PPP1R9A/PARD3/ELL/SLC9A1/PPP6R2/STAU1/BOD1/SH3YL1/ERBB2/SOD1/CTNNB1/TPRN/VCP/LGALS3/PTPN1/JUP/BAD/DLG1/PPP1CA/MAPK14	28
GO:0019903	protein phosphatase binding	22/2130	150/18367	0.146965632919477	0.58876086102501	EGFR/HSP90B1/IQGAP1/MET/ANAPC5/KCNN4/PPP1R9A/PARD3/SLC9A1/PPP6R2/STAU1/BOD1/ERBB2/SOD1/CTNNB1/VCP/LGALS3/PTPN1/JUP/BAD/PPP1CA/MAPK14	22
GO:0000295	adenine nucleotide transmembrane transporter activity	4/2130	18/18367	0.147733352581921	0.58876086102501	SLC19A1/SLC25A4/SLC25A5/SLC25A6	4
GO:0005346	purine ribonucleotide transmembrane transporter activity	4/2130	18/18367	0.147733352581921	0.58876086102501	SLC19A1/SLC25A4/SLC25A5/SLC25A6	4
GO:0055102	lipase inhibitor activity	4/2130	18/18367	0.147733352581921	0.58876086102501	ANXA2/ANXA5/ANXA3/ANXA1	4
GO:0002020	protease binding	20/2130	135/18367	0.149971907762634	0.594451486105231	ADAMTSL4/LRP1/ITGAV/ITGB1/OS9/PSAP/CFLAR/TIMP3/CST3/CLTC/ANXA2/NDUFS7/DPP4/PARK7/SUMO1/SART3/VCP/FLOT1/DVL3/DERL2	20
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	13/2130	82/18367	0.150583455272024	0.594451486105231	SYT7/SCIN/KRIT1/PARD3/SLC9A1/ANXA2/EXOC1/LDLRAP1/PHLDA3/GSDMD/SVIL/PFN1/TWF2	13
GO:0000340	RNA 7-methylguanosine cap binding	3/2130	12/18367	0.15470335228801	0.594451486105231	NCBP3/CYFIP1/DCPS	3
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	3/2130	12/18367	0.15470335228801	0.594451486105231	AKR1B1/AKR7A2/AKR1A1	3
GO:0005527	macrolide binding	3/2130	12/18367	0.15470335228801	0.594451486105231	FKBP2/FKBP4/FKBP3	3
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	3/2130	12/18367	0.15470335228801	0.594451486105231	CDK6/BRD4/CDK7	3
GO:0008429	phosphatidylethanolamine binding	3/2130	12/18367	0.15470335228801	0.594451486105231	PEBP1/NF1/ANXA11	3
GO:0017154	semaphorin receptor activity	3/2130	12/18367	0.15470335228801	0.594451486105231	NRP2/MET/NRP1	3
GO:0034452	dynactin binding	3/2130	12/18367	0.15470335228801	0.594451486105231	SNX6/SNX5/HOOK3	3
GO:0045295	gamma-catenin binding	3/2130	12/18367	0.15470335228801	0.594451486105231	DSC3/CDH1/TCF7L2	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	9/2130	53/18367	0.15519351528393	0.594451486105231	SLC19A1/SLC29A3/SLC25A4/SLC35B4/SLC25A5/SLC35D2/SLC35E3/SLC35A2/SLC25A6	9
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	20/2130	136/18367	0.157754323336777	0.602132698933332	IDH1/ADH5/HADHA/LDHB/AKR1B1/HSD17B1/DCXR/HADHB/KDSR/D2HGDH/AKR7A2/IDH3B/HIBADH/IDH2/MDH2/IDH3G/GRHPR/AKR1A1/MDH1/HSD17B10	20
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	7/2130	39/18367	0.159467708104692	0.60441606848072	POLR2J3/POLR2L/POLR2D/POLR2A/CRCP/POLR2F/POLR3K	7
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	7/2130	39/18367	0.159467708104692	0.60441606848072	IQGAP2/ZFYVE16/IQGAP1/FERMT2/PARD3/CYTH3/PHLDA3	7
GO:0010314	phosphatidylinositol-5-phosphate binding	4/2130	19/18367	0.170965027720967	0.64341070359767	PHLDA3/PLEKHA5/PLEKHF1/SNX5	4
GO:0030165	PDZ domain binding	13/2130	84/18367	0.171270317537189	0.64341070359767	ATP2B1/ADRB1/GJA1/CRIM1/LNX1/BAIAP2/PLEKHA1/TGFBR3/GNG5/GNG12/CADM1/PSEN1/ARHGAP29	13
GO:0019787	ubiquitin-like protein transferase activity	60/2130	458/18367	0.172035068997125	0.64341070359767	RNF43/SIAH1/TTC3/TRIM44/SHPRH/TRIM6/MYCBP2/MED7/LNX1/UFL1/DTX4/CBX4/CUL1/ZNRF3/LMO7/TRIM28/MED10/RNF170/HUWE1/KLHL42/NSMCE1/RLIM/UBE2Q1/UBE3C/RNF181/UBE2A/ITCH/MYLIP/NHLRC3/UBR5/CUL5/RNF217/ANAPC11/UBE2I/CBLL1/LTN1/RANBP2/AKTIP/RNF13/UBE4B/CDC23/STUB1/RNF7/RNF114/HERC4/FBXO21/SUMO2/RNF8/MED30/IRF2BPL/UBE2J2/RBCK1/MED12/UBE2N/NEDD4/MDM2/RBBP6/RNF121/WWP1/TRIM27	60
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	8/2130	47/18367	0.172130169781665	0.64341070359767	PTP4A1/DUSP6/DUSP9/DUSP14/PTPMT1/DUSP5/DUSP22/DUSP1	8
GO:0003925	G protein activity	7/2130	40/18367	0.175222936186394	0.650425913858507	RASL11B/KRAS/RAC1/MRAS/RAB1A/RAB5C/RAB7A	7
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	7/2130	40/18367	0.175222936186394	0.650425913858507	PRDX5/TNFAIP8/SNCA/CTSH/BAD/PRDX3/RPS27L	7
GO:0004364	glutathione transferase activity	5/2130	26/18367	0.17637684079637	0.650425913858507	PTGES/GSTP1/GSTZ1/GSTK1/GSTA4	5
GO:1990841	promoter-specific chromatin binding	10/2130	62/18367	0.176637338563773	0.650425913858507	ISL1/ZNF609/DDX5/TRIM28/DNMT1/EGR1/HNRNPU/POLR2A/HSF1/FOXC1	10
GO:0005154	epidermal growth factor receptor binding	6/2130	33/18367	0.177007052203191	0.650425913858507	EFEMP1/ATXN2/VAV3/SHC1/SNX4/SNX2	6
GO:0001098	basal transcription machinery binding	11/2130	70/18367	0.183347284798707	0.665215200686178	WDR43/SMYD2/NOP58/NCOA3/BRD4/EDF1/WAC/HNRNPU/RTF1/PAF1/LEO1	11
GO:0001099	basal RNA polymerase II transcription machinery binding	11/2130	70/18367	0.183347284798707	0.665215200686178	WDR43/SMYD2/NOP58/NCOA3/BRD4/EDF1/WAC/HNRNPU/RTF1/PAF1/LEO1	11
GO:0004860	protein kinase inhibitor activity	11/2130	70/18367	0.183347284798707	0.665215200686178	CDKN1C/PKIB/NCK1/SOCS1/YWHAB/NPM1/SNCA/YWHAG/SPRED2/HEXIM1/HSPB1	11
GO:0004535	poly(A)-specific ribonuclease activity	3/2130	13/18367	0.184713814950682	0.665215200686178	CNOT6L/CNOT1/CNOT7	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/2130	13/18367	0.184713814950682	0.665215200686178	TXNRD2/TXNDC17/PRDX3	3
GO:0061133	endopeptidase activator activity	3/2130	13/18367	0.184713814950682	0.665215200686178	PSME3/APH1A/PSME1	3
GO:0030971	receptor tyrosine kinase binding	12/2130	78/18367	0.188807637449325	0.677706884089632	EIF3A/PTPN14/CPNE3/NCK1/BLNK/PTPN2/SHC1/CRK/PTPN11/PTPN1/YWHAG/SQSTM1	12
GO:0022853	active ion transmembrane transporter activity	36/2130	267/18367	0.189559374932038	0.678159611968083	ATP2B1/SLC26A2/SLC38A2/SLC12A9/SLC19A1/SLC1A3/SLC22A11/SLC6A4/SLC38A1/SLC25A4/SLC20A2/SLC12A4/COX6A1/SLC13A4/CYB5A/SLC9A1/SLC25A3/COX5B/SLC25A5/UQCR10/UQCRFS1/UQCRC1/COX4I1/SLC10A3/COX5A/SURF1/SLC25A6/ATP6V1C2/ATP6V1G1/COX8A/ATP1A1/COX15/ATP13A3/UQCRH/CYC1/ATP6V0E1	36
GO:0061659	ubiquitin-like protein ligase activity	42/2130	316/18367	0.193181108380102	0.68298281544838	RNF43/SIAH1/TRIM44/SHPRH/TRIM6/MYCBP2/MED7/UFL1/DTX4/CBX4/ZNRF3/MED10/RNF170/HUWE1/NSMCE1/RLIM/UBE3C/RNF181/ITCH/MYLIP/NHLRC3/UBR5/RNF217/ANAPC11/CBLL1/LTN1/RANBP2/RNF13/UBE4B/STUB1/RNF7/RNF114/RNF8/MED30/IRF2BPL/MED12/NEDD4/MDM2/RBBP6/RNF121/WWP1/TRIM27	42
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	6/2130	34/18367	0.195313311595987	0.68298281544838	DICER1/ELAC2/RNASEH1/ENDOV/POP7/RPP38	6
GO:0030291	protein serine/threonine kinase inhibitor activity	6/2130	34/18367	0.195313311595987	0.68298281544838	CDKN1C/PKIB/YWHAG/SPRED2/HEXIM1/HSPB1	6
GO:0016505	peptidase activator activity involved in apoptotic process	4/2130	20/18367	0.195356039166378	0.68298281544838	CTSC/CTSH/BAD/RPS27L	4
GO:0030506	ankyrin binding	4/2130	20/18367	0.195356039166378	0.68298281544838	PLEC/CDH1/SPTBN1/ATP1A1	4
GO:0031690	adrenergic receptor binding	4/2130	20/18367	0.195356039166378	0.68298281544838	ADRB1/GNAS/C1QBP/NEDD4	4
GO:0097001	ceramide binding	4/2130	20/18367	0.195356039166378	0.68298281544838	PSAP/VDAC2/VDAC1/GLTP	4
GO:0015215	nucleotide transmembrane transporter activity	5/2130	27/18367	0.197208137670981	0.68298281544838	SLC19A1/SLC25A36/SLC25A4/SLC25A5/SLC25A6	5
GO:0022884	macromolecule transmembrane transporter activity	5/2130	27/18367	0.197208137670981	0.68298281544838	TOMM7/HNRNPA3/SEC61G/TOMM20/TMED10	5
GO:0035255	ionotropic glutamate receptor binding	5/2130	27/18367	0.197208137670981	0.68298281544838	FUS/GNAS/CANX/FLOT1/SQSTM1	5
GO:0016763	pentosyltransferase activity	8/2130	49/18367	0.202379433464692	0.698660209795306	GXYLT1/QPRT/APRT/PARP1/PPAT/NAPRT/MTAP/UMPS	8
GO:0035259	glucocorticoid receptor binding	3/2130	14/18367	0.216070552194748	0.73620681595687	NRIP1/ETS2/TACC1	3
GO:0140666	annealing activity	3/2130	14/18367	0.216070552194748	0.73620681595687	DDX3X/ANXA1/FXR1	3
GO:0008276	protein methyltransferase activity	13/2130	88/18367	0.216529005788793	0.73620681595687	SETD5/SMYD2/DNMT3A/ASH1L/SUZ12/KMT2C/NSD1/HEMK1/KMT2A/TRMT112/PRMT2/PRMT1/EHMT1	13
GO:0030159	signaling receptor complex adaptor activity	8/2130	50/18367	0.218249974880228	0.73620681595687	DLG5/LDLRAP1/NCK1/BLNK/SHC1/CRK/PTPN11/SPAG9	8
GO:0001968	fibronectin binding	5/2130	28/18367	0.21882884301494	0.73620681595687	CCDC80/FBLN1/ITGAV/ITGB1/CTSL	5
GO:0003785	actin monomer binding	5/2130	28/18367	0.21882884301494	0.73620681595687	LIMA1/TMSB10/COBLL1/PFN1/TWF2	5
GO:0017056	structural constituent of nuclear pore	5/2130	28/18367	0.21882884301494	0.73620681595687	UPF3A/TPR/NUP58/NUTF2/NUP54	5
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	5/2130	28/18367	0.21882884301494	0.73620681595687	WDR45B/SNX14/PHLDA3/PLEKHA5/SNX5	5
GO:0015216	purine nucleotide transmembrane transporter activity	4/2130	21/18367	0.220726213271202	0.73620681595687	SLC19A1/SLC25A4/SLC25A5/SLC25A6	4
GO:0070577	lysine-acetylated histone binding	4/2130	21/18367	0.220726213271202	0.73620681595687	BRD7/BRD4/SMARCA4/KMT2A	4
GO:0140033	acetylation-dependent protein binding	4/2130	21/18367	0.220726213271202	0.73620681595687	BRD7/BRD4/SMARCA4/KMT2A	4
GO:0042277	peptide binding	42/2130	321/18367	0.223270257389324	0.738209844354233	ENPEP/DHCR24/LRP1/LRPAP1/MME/ITM2C/IGF1R/IDE/KPNB1/CST3/PTGES2/CTSV/PTGES/PPIB/ITM2B/CLTA/CALR/SRP54/NKTR/SRP14/NPEPPS/KDELR2/LDLRAP1/ADNP/PFDN2/HSP90AB1/PPIE/PFDN1/KDELR1/PPIA/PRLR/NFKBIA/TOMM20/PFDN5/NUP58/PPIG/PPARG/PPIH/KPNA6/SRP68/AP2M1/PPIC	42
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	9/2130	58/18367	0.225470036512655	0.738209844354233	CHM/PTGES/GSTP1/SMS/FDPS/GSTZ1/GSTK1/GSTA4/SRM	9
GO:0018024	histone-lysine N-methyltransferase activity	7/2130	43/18367	0.22609378996827	0.738209844354233	SETD5/SMYD2/ASH1L/KMT2C/NSD1/KMT2A/EHMT1	7
GO:0030544	Hsp70 protein binding	7/2130	43/18367	0.22609378996827	0.738209844354233	RPS3/DNAJB14/STUB1/SNCA/DNAJC8/DNAJB1/ST13	7
GO:0032266	phosphatidylinositol-3-phosphate binding	7/2130	43/18367	0.22609378996827	0.738209844354233	WDR45B/PARD3/PHLDA3/PLEKHA5/PLEKHF1/VPS36/SNX27	7
GO:0034062	5'-3' RNA polymerase activity	7/2130	43/18367	0.22609378996827	0.738209844354233	POLR2J3/POLR2L/POLR2D/POLR2A/CRCP/POLR2F/POLR3K	7
GO:0097747	RNA polymerase activity	7/2130	43/18367	0.22609378996827	0.738209844354233	POLR2J3/POLR2L/POLR2D/POLR2A/CRCP/POLR2F/POLR3K	7
GO:1901681	sulfur compound binding	35/2130	265/18367	0.22976734276279	0.747951350014607	NRP2/ADAMTS1/CCDC80/FBN1/APP/FSTL1/SOD3/APLP2/LRP1/ADGRG1/LRPAP1/PCOLCE2/BMP7/PTGES2/ACADVL/PTGES/SMOC1/GSTP1/HADHA/TGFBR3/NAV2/DBI/PTPRF/NRP1/ILVBL/RPL22/TKT/PPIA/AAMP/PDCD5/ACBD6/ACBD3/RPL29/ECI2/PRMT1	35
GO:0005484	SNAP receptor activity	6/2130	36/18367	0.233862797233391	0.75196192193311	GOSR1/VAMP8/SEC22B/STX16/VAMP2/STX7	6
GO:0023023	MHC protein complex binding	6/2130	36/18367	0.233862797233391	0.75196192193311	CD81/HSP90AA1/HSPA8/HSP90AB1/YWHAE/ANXA11	6
GO:0042805	actinin binding	6/2130	36/18367	0.233862797233391	0.75196192193311	DAG1/CSRP2/PALLD/NFKB1/PPARG/PDLIM1	6
GO:0017022	myosin binding	11/2130	74/18367	0.235161523556572	0.75196192193311	VEZT/FUS/TRIOBP/CALD1/RAB14/MYL12B/RAB25/RAB6A/TRPM7/VAMP2/ARFGEF1	11
GO:0019210	kinase inhibitor activity	11/2130	74/18367	0.235161523556572	0.75196192193311	CDKN1C/PKIB/NCK1/SOCS1/YWHAB/NPM1/SNCA/YWHAG/SPRED2/HEXIM1/HSPB1	11
GO:0019905	syntaxin binding	11/2130	74/18367	0.235161523556572	0.75196192193311	SYT7/SLC6A4/VPS52/TMED9/VAMP8/PTPN2/SEC22B/STX16/VAMP2/TMED10/STX7	11
GO:0036002	pre-mRNA binding	9/2130	59/18367	0.240794257851621	0.758536430648927	SF1/DDX5/SRSF2/TRA2B/SNRPC/HNRNPL/HNRNPU/PRPF8/HNRNPA1	9
GO:0015301	anion:anion antiporter activity	5/2130	29/18367	0.241130193644097	0.758536430648927	SLC26A2/SLC19A1/SLC25A4/SLC25A5/SLC25A6	5
GO:0051059	NF-kappaB binding	5/2130	29/18367	0.241130193644097	0.758536430648927	COMMD7/COMMD6/NPM1/NFKBIA/CDK5RAP3	5
GO:0016791	phosphatase activity	36/2130	275/18367	0.242806325298924	0.758536430648927	PLPP3/PTP4A1/TAB1/PTPRM/DUSP6/DUSP9/CTDSPL/TIMM50/EPHX2/PTPN14/DUSP14/CPPED1/PTPRF/PTPMT1/G6PC3/PTPN12/PTPN2/FIG4/PGP/ENOPH1/PHLPP2/TNS3/PPM1G/PTPRE/NT5C/CAMK2G/PTPN11/PTPN1/DUSP5/DUSP22/ATP1A1/DLG1/PPP2CB/PPP1CA/PPP4C/DUSP1	36
GO:0017124	SH3 domain binding	18/2130	130/18367	0.246444362860557	0.758536430648927	LRP2/GJA1/FUT8/HCLS1/KHDRBS1/BCAR1/SH3BP1/PTPN12/ABI1/ERRFI1/CRK/USP8/MVB12A/RAPGEF1/ZNF106/QKI/VASP/DNM2	18
GO:0008320	protein transmembrane transporter activity	4/2130	22/18367	0.246894765615597	0.758536430648927	TOMM7/SEC61G/TOMM20/TMED10	4
GO:0015296	anion:cation symporter activity	4/2130	22/18367	0.246894765615597	0.758536430648927	SLC12A9/SLC6A4/SLC12A4/SLC13A4	4
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/2130	22/18367	0.246894765615597	0.758536430648927	PRDX5/TNFAIP8/SNCA/PRDX3	4
GO:0004467	long-chain fatty acid-CoA ligase activity	3/2130	15/18367	0.248413683468975	0.758536430648927	SLC27A2/SLC27A3/ACSF2	3
GO:0004549	tRNA-specific ribonuclease activity	3/2130	15/18367	0.248413683468975	0.758536430648927	ELAC2/POP7/RPP38	3
GO:0004559	alpha-mannosidase activity	3/2130	15/18367	0.248413683468975	0.758536430648927	MAN2A1/EDEM2/MAN1A2	3
GO:0005041	low-density lipoprotein particle receptor activity	3/2130	15/18367	0.248413683468975	0.758536430648927	LRP2/LRP1/OLR1	3
GO:0005545	1-phosphatidylinositol binding	3/2130	15/18367	0.248413683468975	0.758536430648927	ZFYVE16/SCIN/EEA1	3
GO:0032794	GTPase activating protein binding	3/2130	15/18367	0.248413683468975	0.758536430648927	CDH1/GNAI1/PIN1	3
GO:0050998	nitric-oxide synthase binding	3/2130	15/18367	0.248413683468975	0.758536430648927	SLC6A4/CALM1/DNM2	3
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	3/2130	15/18367	0.248413683468975	0.758536430648927	CFLAR/CASP4/CASP2	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	6/2130	37/18367	0.253959595152381	0.769458040948353	ADH5/ALDH7A1/AKR1B1/ALDH18A1/PDHX/PDHA1	6
GO:0071949	FAD binding	6/2130	37/18367	0.253959595152381	0.769458040948353	DHCR24/ERO1B/SQLE/AIFM1/D2HGDH/CYB5R1	6
GO:0004842	ubiquitin-protein transferase activity	55/2130	433/18367	0.254119906512463	0.769458040948353	RNF43/SIAH1/TTC3/TRIM44/SHPRH/TRIM6/MYCBP2/MED7/LNX1/DTX4/CUL1/ZNRF3/LMO7/TRIM28/MED10/RNF170/HUWE1/KLHL42/NSMCE1/RLIM/UBE2Q1/UBE3C/RNF181/UBE2A/ITCH/MYLIP/NHLRC3/UBR5/CUL5/RNF217/ANAPC11/CBLL1/LTN1/AKTIP/RNF13/UBE4B/CDC23/STUB1/RNF7/RNF114/HERC4/FBXO21/RNF8/MED30/IRF2BPL/UBE2J2/RBCK1/MED12/UBE2N/NEDD4/MDM2/RBBP6/RNF121/WWP1/TRIM27	55
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	9/2130	60/18367	0.256468469787276	0.774406187324254	DHCR24/PTGES2/ACADVL/AKR1B1/ACADS/TECR/IVD/COX15/DUS1L	9
GO:0019887	protein kinase regulator activity	27/2130	204/18367	0.260523005950198	0.784463717916708	IQGAP1/CDKN1C/PKIB/CCNG2/CCND1/CCND3/NCK1/HSP90AB1/SOCS1/ABI1/CD24/RPLP1/DDX3X/CCNG1/YWHAB/NPM1/SNCA/GCN1/STK3/YWHAG/SPRED2/CALM1/HMGB1/ERBB3/HEXIM1/CDC37/HSPB1	27
GO:0051213	dioxygenase activity	13/2130	92/18367	0.266251417534455	0.799491791156091	ASPH/P4HB/TYW5/RSBN1L/KDM5A/CDO1/TET2/ETHE1/POR/ADI1/ALKBH7/PHYH/KDM5B	13
GO:0043621	protein self-association	9/2130	61/18367	0.27245874637697	0.813687001537928	PLEC/CTSC/CRK/MDH2/TDG/HSF1/PPARG/VAMP2/SLC2A1	9
GO:0061134	peptidase regulator activity	30/2130	230/18367	0.273323690985601	0.813687001537928	ITIH5/APP/APLP2/SPINT1/FBLN1/PCOLCE2/SERPINF1/CRIM1/CTSC/GPC3/SPINT2/TIMP3/CST3/PEBP1/PRDX5/ANXA2/SERPINH1/TNFAIP8/ROCK1/VCP/CAST/PSME3/SNCA/CTSH/SERPINB1/BAD/PRDX3/RPS27L/APH1A/PSME1	30
GO:0030215	semaphorin receptor binding	4/2130	23/18367	0.273683681311606	0.813687001537928	SEMA6A/SEMA6D/SEMA3F/SH3BP1	4
GO:0061630	ubiquitin protein ligase activity	39/2130	304/18367	0.273981324318583	0.813687001537928	RNF43/SIAH1/TRIM44/SHPRH/TRIM6/MYCBP2/MED7/DTX4/ZNRF3/MED10/RNF170/HUWE1/NSMCE1/RLIM/UBE3C/RNF181/ITCH/MYLIP/NHLRC3/UBR5/RNF217/ANAPC11/CBLL1/LTN1/RNF13/UBE4B/STUB1/RNF7/RNF114/RNF8/MED30/IRF2BPL/MED12/NEDD4/MDM2/RBBP6/RNF121/WWP1/TRIM27	39
GO:0008168	methyltransferase activity	28/2130	214/18367	0.276275775133803	0.818259399576619	MTR/RNMT/TRMT11/COMT/SETD5/CIAPIN1/DNMT1/SMYD2/DNMT3A/ASH1L/SUZ12/CMTR2/KMT2C/NSD1/HEMK1/COQ5/GCSH/KMT2A/EMG1/TRMT112/PRMT2/METTL2B/TYW3/ECE2/PRMT1/METTL7A/TRMT10A/EHMT1	28
GO:0140296	general transcription initiation factor binding	7/2130	46/18367	0.281289948862229	0.822225403216055	TAF12/NOP58/PSMC5/EDF1/TAF11/HNRNPU/TAF1B	7
GO:0004698	calcium-dependent protein kinase C activity	3/2130	16/18367	0.281407402761214	0.822225403216055	PRKCZ/PRKCH/PKN2	3
GO:0005092	GDP-dissociation inhibitor activity	3/2130	16/18367	0.281407402761214	0.822225403216055	CHM/CHML/GDI2	3
GO:0005283	amino acid:sodium symporter activity	3/2130	16/18367	0.281407402761214	0.822225403216055	SLC38A2/SLC1A3/SLC38A1	3
GO:0016208	AMP binding	3/2130	16/18367	0.281407402761214	0.822225403216055	ACSS1/APRT/PFKL	3
GO:0005544	calcium-dependent phospholipid binding	8/2130	54/18367	0.285772801613946	0.830503262599244	SYT7/CPNE8/ANXA2/ANXA5/CPNE3/ANXA3/ANXA1/ANXA11	8
GO:0008408	3'-5' exonuclease activity	8/2130	54/18367	0.285772801613946	0.830503262599244	REXO4/EXOSC7/XRN2/RAD50/CNOT6L/APEX2/CNOT1/CNOT7	8
GO:0016878	acid-thiol ligase activity	5/2130	31/18367	0.287334264346183	0.8305875801367	ACSS1/SLC27A2/SLC27A3/ACSF2/SUCLG1	5
GO:0140142	nucleocytoplasmic carrier activity	5/2130	31/18367	0.287334264346183	0.8305875801367	KPNB1/CSE1L/NUTF2/KPNA6/RAN	5
GO:0016776	phosphotransferase activity, phosphate group as acceptor	6/2130	39/18367	0.295419600892557	0.833585596361827	IP6K2/PMVK/AK6/AK3/DLG1/CMPK1	6
GO:0019825	oxygen binding	6/2130	39/18367	0.295419600892557	0.833585596361827	HBA1/HBA2/PARK7/HBG2/HBB/HBG1	6
GO:0050997	quaternary ammonium group binding	6/2130	39/18367	0.295419600892557	0.833585596361827	CHMP2A/ILVBL/TKT/NF1/VDAC2/VDAC1	6
GO:0061650	ubiquitin-like protein conjugating enzyme activity	6/2130	39/18367	0.295419600892557	0.833585596361827	UBE2Q1/UBE2A/UBE2I/AKTIP/UBE2J2/UBE2N	6
GO:0016741	transferase activity, transferring one-carbon groups	29/2130	225/18367	0.300269740765335	0.833585596361827	MTR/RNMT/TRMT11/COMT/SETD5/CIAPIN1/DNMT1/SMYD2/DNMT3A/ASH1L/SUZ12/CMTR2/KMT2C/NSD1/HEMK1/COQ5/GCSH/ATIC/KMT2A/EMG1/TRMT112/PRMT2/METTL2B/TYW3/ECE2/PRMT1/METTL7A/TRMT10A/EHMT1	29
GO:0035254	glutamate receptor binding	7/2130	47/18367	0.300392910201328	0.833585596361827	FUS/GNAS/CANX/HOMER1/FLOT1/CALM1/SQSTM1	7
GO:0051537	2 iron, 2 sulfur cluster binding	4/2130	24/18367	0.300920490621002	0.833585596361827	CIAPIN1/NDUFV2/CISD1/UQCRFS1	4
GO:0070840	dynein complex binding	4/2130	24/18367	0.300920490621002	0.833585596361827	ATMIN/SMC3/TPR/SNCA	4
GO:0048029	monosaccharide binding	10/2130	71/18367	0.306177117012868	0.833585596361827	LMAN1/COLEC12/MANBA/LMAN2/SLC2A8/UGP2/PHYH/ALDOA/RPIA/PFKL	10
GO:0008378	galactosyltransferase activity	5/2130	32/18367	0.311018529876066	0.833585596361827	B3GNT3/C1GALT1C1/C1GALT1/B4GALT4/B4GALT1	5
GO:0015605	organophosphate ester transmembrane transporter activity	5/2130	32/18367	0.311018529876066	0.833585596361827	SLC19A1/SLC25A36/SLC25A4/SLC25A5/SLC25A6	5
GO:0050699	WW domain binding	5/2130	32/18367	0.311018529876066	0.833585596361827	TCEAL4/NDFIP2/TRAF4/TCEAL8/DNM2	5
GO:0071889	14-3-3 protein binding	5/2130	32/18367	0.311018529876066	0.833585596361827	PRKCZ/PPP1R12A/ZFP36L1/BAD/SRPK2	5
GO:0004697	protein kinase C activity	3/2130	17/18367	0.314744012010833	0.833585596361827	PRKCZ/PRKCH/PKN2	3
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/2130	17/18367	0.314744012010833	0.833585596361827	PTPRM/PTPRF/PTPRE	3
GO:0005324	long-chain fatty acid transporter activity	3/2130	17/18367	0.314744012010833	0.833585596361827	SLC27A2/SLC27A3/SLC2A1	3
GO:0008308	voltage-gated anion channel activity	3/2130	17/18367	0.314744012010833	0.833585596361827	ANO6/VDAC2/VDAC1	3
GO:0008381	mechanosensitive ion channel activity	3/2130	17/18367	0.314744012010833	0.833585596361827	TMEM63A/TMEM150C/TMC5	3
GO:0008484	sulfuric ester hydrolase activity	3/2130	17/18367	0.314744012010833	0.833585596361827	GNS/ARSD/STS	3
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	3/2130	17/18367	0.314744012010833	0.833585596361827	CTSH/BAD/RPS27L	3
GO:0015377	cation:chloride symporter activity	3/2130	17/18367	0.314744012010833	0.833585596361827	SLC12A9/SLC6A4/SLC12A4	3
GO:0017081	chloride channel regulator activity	3/2130	17/18367	0.314744012010833	0.833585596361827	VAMP8/SGK3/STX7	3
GO:0019198	transmembrane receptor protein phosphatase activity	3/2130	17/18367	0.314744012010833	0.833585596361827	PTPRM/PTPRF/PTPRE	3
GO:0034185	apolipoprotein binding	3/2130	17/18367	0.314744012010833	0.833585596361827	LRP1/HSPD1/CANX	3
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3/2130	17/18367	0.314744012010833	0.833585596361827	ATP6V1C2/ATP6V1G1/ATP6V0E1	3
GO:0042800	histone methyltransferase activity (H3-K4 specific)	3/2130	17/18367	0.314744012010833	0.833585596361827	ASH1L/KMT2C/KMT2A	3
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	3/2130	17/18367	0.314744012010833	0.833585596361827	ATP6V1C2/ATP6V1G1/ATP6V0E1	3
GO:0046961	proton-transporting ATPase activity, rotational mechanism	3/2130	17/18367	0.314744012010833	0.833585596361827	ATP6V1C2/ATP6V1G1/ATP6V0E1	3
GO:0048531	beta-1,3-galactosyltransferase activity	3/2130	17/18367	0.314744012010833	0.833585596361827	B3GNT3/C1GALT1C1/C1GALT1	3
GO:0004532	exoribonuclease activity	6/2130	40/18367	0.316630777017174	0.833585596361827	EXOSC7/XRN2/CNOT6L/CNOT1/DCPS/CNOT7	6
GO:0017080	sodium channel regulator activity	6/2130	40/18367	0.316630777017174	0.833585596361827	FXYD3/GPD1L/SGK3/PRSS8/RANGRF/NEDD4	6
GO:0031492	nucleosomal DNA binding	6/2130	40/18367	0.316630777017174	0.833585596361827	HMGN3/SMARCA4/CHD4/SMARCC1/HMGN1/ACTL6A	6
GO:0042169	SH2 domain binding	6/2130	40/18367	0.316630777017174	0.833585596361827	DAG1/ARHGAP5/KHDRBS1/BLNK/CRK/SQSTM1	6
GO:0004527	exonuclease activity	11/2130	80/18367	0.321391758128694	0.833585596361827	REXO4/EXOSC7/XRN2/RAD50/CNOT6L/APEX2/CNOT1/DCPS/CNOT7/PLD3/DDX1	11
GO:0140098	catalytic activity, acting on RNA	48/2130	386/18367	0.324426233768694	0.833585596361827	IARS2/POLR2J3/RNMT/TRMT11/DDX50/RNASET2/SND1/DDX24/DDX5/DHX36/DTD1/EXOSC7/TYW5/DICER1/POLR2L/XRN2/CMTR2/ELAC2/G3BP1/DDX3X/RNASEH1/DDX17/CNOT6L/DDX18/ENDOV/POLR2D/EIF4A1/POLR2A/CRCP/DDX21/EMG1/POLR2F/POP7/DDX52/RTCB/DDX42/METTL2B/TYW3/CNOT1/DDX56/DCPS/CNOT7/POLR3K/DDX46/TRMT10A/DDX1/DUS1L/RPP38	48
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	2/2130	10/18367	0.326051930680272	0.833585596361827	RAD50/XRCC1	2
GO:0001094	TFIID-class transcription factor complex binding	2/2130	10/18367	0.326051930680272	0.833585596361827	NOP58/EDF1	2
GO:0008190	eukaryotic initiation factor 4E binding	2/2130	10/18367	0.326051930680272	0.833585596361827	DDX3X/EIF4G1	2
GO:0008239	dipeptidyl-peptidase activity	2/2130	10/18367	0.326051930680272	0.833585596361827	CTSC/DPP4	2
GO:0016783	sulfurtransferase activity	2/2130	10/18367	0.326051930680272	0.833585596361827	TSTD1/MOCS2	2
GO:0019869	chloride channel inhibitor activity	2/2130	10/18367	0.326051930680272	0.833585596361827	VAMP8/STX7	2
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/2130	10/18367	0.326051930680272	0.833585596361827	SLC27A2/SLC27A3	2
GO:0032356	oxidized DNA binding	2/2130	10/18367	0.326051930680272	0.833585596361827	RPS3/XRCC1	2
GO:0033204	ribonuclease P RNA binding	2/2130	10/18367	0.326051930680272	0.833585596361827	POP7/RPP38	2
GO:0034713	type I transforming growth factor beta receptor binding	2/2130	10/18367	0.326051930680272	0.833585596361827	FERMT2/SNX6	2
GO:0035612	AP-2 adaptor complex binding	2/2130	10/18367	0.326051930680272	0.833585596361827	AAK1/LDLRAP1	2
GO:0045503	dynein light chain binding	2/2130	10/18367	0.326051930680272	0.833585596361827	DYNC1I2/HOOK3	2
GO:0051880	G-quadruplex DNA binding	2/2130	10/18367	0.326051930680272	0.833585596361827	DHX36/RAD50	2
GO:0070567	cytidylyltransferase activity	2/2130	10/18367	0.326051930680272	0.833585596361827	CDS1/CDS2	2
GO:0005160	transforming growth factor beta receptor binding	4/2130	25/18367	0.328440484176844	0.833792704561356	FERMT2/TGFBR3/RASL11B/SNX6	4
GO:0035035	histone acetyltransferase binding	4/2130	25/18367	0.328440484176844	0.833792704561356	GLI3/EGR1/EID1/SP1	4
GO:0035925	mRNA 3'-UTR AU-rich region binding	4/2130	25/18367	0.328440484176844	0.833792704561356	DHX36/HNRNPA0/NUDT21/ZFP36L1	4
GO:0016757	glycosyltransferase activity	34/2130	270/18367	0.330509331946566	0.837084382780556	CHPF/HEXA/EXTL2/RPN2/GALNT11/AGL/GXYLT1/FUT8/GLT8D1/QPRT/B3GAT3/HEXB/OSTC/B3GNT3/MGAT3/DPY19L1/GALNT18/C1GALT1C1/C1GALT1/UGGT2/B4GALT4/B4GALT1/APRT/PARP1/GALNT1/PPAT/TMTC3/NAPRT/MTAP/EXT2/ST3GAL6/UMPS/ALG5/RPN1	34
GO:0140323	solute:anion antiporter activity	5/2130	33/18367	0.334949150889079	0.846351700614829	SLC26A2/SLC19A1/SLC25A4/SLC25A5/SLC25A6	5
GO:0016877	ligase activity, forming carbon-sulfur bonds	6/2130	41/18367	0.338062680718796	0.851094399296393	ACSS1/SLC27A2/NAE1/SLC27A3/ACSF2/SUCLG1	6
GO:0004175	endopeptidase activity	53/2130	430/18367	0.338396389388142	0.851094399296393	ADAMTS1/ADAMTS6/PDIA3/MME/NCSTN/CTSC/LGMN/CTSL/CTSF/USP10/SPPL2B/IDE/CFLAR/MMP15/ST14/AFG3L2/CTSV/USP40/CTSD/CASP4/HM13/PSMB2/PSMB6/DPP4/MMP14/PRSS8/SPPL2A/SENP7/SEC11A/USP48/PSMB1/PSMA4/IMMP2L/PSMB5/PSEN1/CAPN1/CASP2/PSMB3/YME1L1/ATG4C/TMEM59/CTSH/USP47/USP8/MBTPS1/SENP6/PSMB4/USP9X/USP34/USP25/ECE2/PMPCA/PMPCB	53
GO:0016758	hexosyltransferase activity	25/2130	197/18367	0.346764026188731	0.861621963433631	CHPF/HEXA/EXTL2/RPN2/GALNT11/AGL/FUT8/B3GAT3/HEXB/OSTC/B3GNT3/MGAT3/DPY19L1/GALNT18/C1GALT1C1/C1GALT1/UGGT2/B4GALT4/B4GALT1/GALNT1/TMTC3/MTAP/EXT2/ALG5/RPN1	25
GO:0008301	DNA binding, bending	3/2130	18/18367	0.348146143896615	0.861621963433631	TFAM/FOXC1/HMGB1	3
GO:0030228	lipoprotein particle receptor activity	3/2130	18/18367	0.348146143896615	0.861621963433631	LRP2/LRP1/OLR1	3
GO:0046624	sphingolipid transporter activity	3/2130	18/18367	0.348146143896615	0.861621963433631	ABCB1/ATP10D/GLTP	3
GO:0047834	D-threo-aldose 1-dehydrogenase activity	3/2130	18/18367	0.348146143896615	0.861621963433631	AKR1B1/AKR7A2/AKR1A1	3
GO:0070122	isopeptidase activity	3/2130	18/18367	0.348146143896615	0.861621963433631	PSMD7/PRPF8/EIF3F	3
GO:0098918	structural constituent of synapse	3/2130	18/18367	0.348146143896615	0.861621963433631	ACTG1/DLG1/ACTN1	3
GO:0008198	ferrous iron binding	4/2130	26/18367	0.35608841933693	0.86911296646004	CDO1/TET2/SNCA/PHYH	4
GO:0030371	translation repressor activity	4/2130	26/18367	0.35608841933693	0.86911296646004	PURA/IREB2/CIRBP/SAMD4B	4
GO:0008376	acetylgalactosaminyltransferase activity	5/2130	34/18367	0.359024295594785	0.86911296646004	CHPF/EXTL2/GALNT11/GALNT18/GALNT1	5
GO:0016831	carboxy-lyase activity	5/2130	34/18367	0.359024295594785	0.86911296646004	GGCX/PDXDC1/PISD/DDT/UMPS	5
GO:0035198	miRNA binding	5/2130	34/18367	0.359024295594785	0.86911296646004	KCNQ1OT1/SOX4/PUM2/DDX21/HNRNPA1	5
GO:0008201	heparin binding	21/2130	166/18367	0.37002165821209	0.86911296646004	NRP2/ADAMTS1/CCDC80/FBN1/APP/FSTL1/SOD3/APLP2/ADGRG1/LRPAP1/PCOLCE2/BMP7/SMOC1/TGFBR3/NAV2/PTPRF/NRP1/RPL22/AAMP/PDCD5/RPL29	21
GO:0002162	dystroglycan binding	2/2130	11/18367	0.370415304893486	0.86911296646004	PLEC/DAG1	2
GO:0005049	nuclear export signal receptor activity	2/2130	11/18367	0.370415304893486	0.86911296646004	CSE1L/RAN	2
GO:0005078	MAP-kinase scaffold activity	2/2130	11/18367	0.370415304893486	0.86911296646004	IQGAP1/SPAG9	2
GO:0005536	glucose binding	2/2130	11/18367	0.370415304893486	0.86911296646004	SLC2A8/UGP2	2
GO:0016273	arginine N-methyltransferase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	PRMT2/PRMT1	2
GO:0016274	protein-arginine N-methyltransferase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	PRMT2/PRMT1	2
GO:0017128	phospholipid scramblase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	XKR8/ANO6	2
GO:0019107	myristoyltransferase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	NMT1/HADHB	2
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	2/2130	11/18367	0.370415304893486	0.86911296646004	HSD17B1/HSD17B10	2
GO:0031434	mitogen-activated protein kinase kinase binding	2/2130	11/18367	0.370415304893486	0.86911296646004	DLG1/PIN1	2
GO:0035251	UDP-glucosyltransferase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	UGGT2/ALG5	2
GO:0043295	glutathione binding	2/2130	11/18367	0.370415304893486	0.86911296646004	PTGES2/PTGES	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/2130	11/18367	0.370415304893486	0.86911296646004	TXNRD2/TXNDC17	2
GO:0047676	arachidonate-CoA ligase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	SLC27A2/SLC27A3	2
GO:0061665	SUMO ligase activity	2/2130	11/18367	0.370415304893486	0.86911296646004	CBX4/RANBP2	2
GO:0097157	pre-mRNA intronic binding	2/2130	11/18367	0.370415304893486	0.86911296646004	HNRNPL/PRPF8	2
GO:0140036	ubiquitin-dependent protein binding	2/2130	11/18367	0.370415304893486	0.86911296646004	IDE/FAAP20	2
GO:1901612	cardiolipin binding	2/2130	11/18367	0.370415304893486	0.86911296646004	MME/GSDMD	2
GO:0019207	kinase regulator activity	29/2130	233/18367	0.371541666561786	0.869872929920035	IQGAP1/TAB1/CDKN1C/PKIB/GSTP1/CCNG2/CCND1/CCND3/NCK1/HSP90AB1/SOCS1/ABI1/CD24/RPLP1/DDX3X/CCNG1/YWHAB/NPM1/SNCA/GCN1/STK3/YWHAG/SPRED2/CALM1/HMGB1/ERBB3/HEXIM1/CDC37/HSPB1	29
GO:0016790	thiolester hydrolase activity	6/2130	43/18367	0.381298773124724	0.881254732149216	ABHD12/ABHD17A/LYPLA1/LYPLA2/LYPLAL1/PNKD	6
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	3/2130	19/18367	0.381367603179549	0.881254732149216	GALNT11/GALNT18/GALNT1	3
GO:0000175	3'-5'-exoribonuclease activity	5/2130	35/18367	0.383146803537223	0.881254732149216	EXOSC7/XRN2/CNOT6L/CNOT1/CNOT7	5
GO:0008139	nuclear localization sequence binding	4/2130	27/18367	0.383719772670138	0.881254732149216	KPNB1/NFKBIA/NUP58/KPNA6	4
GO:0016405	CoA-ligase activity	4/2130	27/18367	0.383719772670138	0.881254732149216	ACSS1/SLC27A2/SLC27A3/ACSF2	4
GO:0043425	bHLH transcription factor binding	4/2130	27/18367	0.383719772670138	0.881254732149216	ISL1/BHLHE41/FHL2/SP1	4
GO:0045499	chemorepellent activity	4/2130	27/18367	0.383719772670138	0.881254732149216	SEMA6A/SEMA6D/SEMA3F/DPP4	4
GO:0051393	alpha-actinin binding	4/2130	27/18367	0.383719772670138	0.881254732149216	DAG1/PALLD/PPARG/PDLIM1	4
GO:0051959	dynein light intermediate chain binding	4/2130	27/18367	0.383719772670138	0.881254732149216	HOOK2/DYNC1H1/DYNLL2/HOOK3	4
GO:0003684	damaged DNA binding	9/2130	68/18367	0.3902730434704	0.894393226806135	XRCC5/MPG/RPS3/DDB1/XRCC6/TDG/XRCC1/RAD23B/HMGB1	9
GO:0072341	modified amino acid binding	12/2130	93/18367	0.393209350270948	0.894393226806135	SYT7/MME/SLC19A1/SCIN/PTGES2/PTGES/HSPA8/ANXA2/FOLR1/GSDMD/TLN1/HMGB1	12
GO:0001786	phosphatidylserine binding	8/2130	60/18367	0.394420398876586	0.894393226806135	SYT7/MME/SCIN/HSPA8/ANXA2/GSDMD/TLN1/HMGB1	8
GO:0001784	phosphotyrosine residue binding	6/2130	44/18367	0.40296423970121	0.894393226806135	RASA1/LDLRAP1/SHC1/CRK/PTPN11/PFN1	6
GO:0008375	acetylglucosaminyltransferase activity	6/2130	44/18367	0.40296423970121	0.894393226806135	HEXA/EXTL2/HEXB/B3GNT3/MGAT3/EXT2	6
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	6/2130	44/18367	0.40296423970121	0.894393226806135	ADH5/ALDH7A1/AKR1B1/ALDH18A1/PDHX/PDHA1	6
GO:0051879	Hsp90 protein binding	6/2130	44/18367	0.40296423970121	0.894393226806135	KPNB1/CDK5/RPS3/STUB1/HSF1/CDC37	6
GO:0016798	hydrolase activity, acting on glycosyl bonds	18/2130	144/18367	0.404944763708535	0.894393226806135	NAGLU/HEXA/GAA/AGL/GM2A/FUCA1/HEXB/TLR3/MAN2A1/MANBA/GUSB/MOGS/GANAB/EDEM2/MPG/MAN1A2/GLB1/TDG	18
GO:0061631	ubiquitin conjugating enzyme activity	5/2130	36/18367	0.4072248690701	0.894393226806135	UBE2Q1/UBE2A/AKTIP/UBE2J2/UBE2N	5
GO:0016410	N-acyltransferase activity	12/2130	94/18367	0.40795196212092	0.894393226806135	USP22/NMT1/ALAS2/NAT10/TGM2/NCOA3/HGSNAT/SAT1/EPC2/NAA10/EPC1/ALAS1	12
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/2130	12/18367	0.41355769541458	0.894393226806135	RPS3/APEX2	2
GO:0004526	ribonuclease P activity	2/2130	12/18367	0.41355769541458	0.894393226806135	POP7/RPP38	2
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	2/2130	12/18367	0.41355769541458	0.894393226806135	CDKN1C/HEXIM1	2
GO:0005024	transforming growth factor beta-activated receptor activity	2/2130	12/18367	0.41355769541458	0.894393226806135	TGFBR3/LTBP1	2
GO:0005095	GTPase inhibitor activity	2/2130	12/18367	0.41355769541458	0.894393226806135	IQGAP2/IQGAP1	2
GO:0008174	mRNA methyltransferase activity	2/2130	12/18367	0.41355769541458	0.894393226806135	RNMT/CMTR2	2
GO:0035256	G protein-coupled glutamate receptor binding	2/2130	12/18367	0.41355769541458	0.894393226806135	HOMER1/CALM1	2
GO:0043047	single-stranded telomeric DNA binding	2/2130	12/18367	0.41355769541458	0.894393226806135	RAD50/HNRNPA1	2
GO:0043422	protein kinase B binding	2/2130	12/18367	0.41355769541458	0.894393226806135	SRSF5/BAD	2
GO:0046790	virion binding	2/2130	12/18367	0.41355769541458	0.894393226806135	ANXA2/PPIA	2
GO:0070410	co-SMAD binding	2/2130	12/18367	0.41355769541458	0.894393226806135	TGIF1/USP9X	2
GO:1900750	oligopeptide binding	2/2130	12/18367	0.41355769541458	0.894393226806135	PTGES2/PTGES	2
GO:0001091	RNA polymerase II general transcription initiation factor binding	3/2130	20/18367	0.41419317329952	0.894393226806135	NOP58/EDF1/HNRNPU	3
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	3/2130	20/18367	0.41419317329952	0.894393226806135	ATP6V1C2/ATP6V1G1/ATP6V0E1	3
GO:0016408	C-acyltransferase activity	3/2130	20/18367	0.41419317329952	0.894393226806135	HADHA/HADHB/SPTSSA	3
GO:0016500	protein-hormone receptor activity	3/2130	20/18367	0.41419317329952	0.894393226806135	LGR4/IGF1R/LGR5	3
GO:0030296	protein tyrosine kinase activator activity	3/2130	20/18367	0.41419317329952	0.894393226806135	ABI1/CD24/ERBB3	3
GO:0031681	G-protein beta-subunit binding	3/2130	20/18367	0.41419317329952	0.894393226806135	GNG5/GNG12/CCT5	3
GO:0050145	nucleoside monophosphate kinase activity	3/2130	20/18367	0.41419317329952	0.894393226806135	AK6/DLG1/CMPK1	3
GO:0061608	nuclear import signal receptor activity	3/2130	20/18367	0.41419317329952	0.894393226806135	KPNB1/NUTF2/KPNA6	3
GO:0031490	chromatin DNA binding	13/2130	103/18367	0.417115292288577	0.898912478808783	HMGN3/SUZ12/SMARCA4/CHD4/ACTN4/LEMD2/HNRNPU/SBNO1/HSF1/SMARCC1/HMGN1/GRHL1/ACTL6A	13
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6/2130	45/18367	0.424573890028865	0.913170826966844	DICER1/ELAC2/RNASEH1/ENDOV/POP7/RPP38	6
GO:0046915	transition metal ion transmembrane transporter activity	5/2130	37/18367	0.431172568119743	0.918807430670254	SLC39A10/TMEM165/SLC25A37/SLC39A1/SLC39A7	5
GO:0015459	potassium channel regulator activity	7/2130	54/18367	0.438257766681163	0.918807430670254	RASA1/PRKCZ/SGK3/YWHAE/SUMO1/AKAP9/DLG1	7
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	7/2130	54/18367	0.438257766681163	0.918807430670254	ASPH/P4HB/TYW5/KDM5A/TET2/PHYH/KDM5B	7
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	4/2130	29/18367	0.438413018380976	0.918807430670254	CDK6/CDK5/CCND3/CDK7	4
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4/2130	29/18367	0.438413018380976	0.918807430670254	DHCR24/PTGES2/AKR1B1/TECR	4
GO:0046625	sphingolipid binding	4/2130	29/18367	0.438413018380976	0.918807430670254	PSAP/VDAC2/VDAC1/GLTP	4
GO:0070273	phosphatidylinositol-4-phosphate binding	4/2130	29/18367	0.438413018380976	0.918807430670254	PLEKHA5/GSDMD/PLEKHF1/SNX5	4
GO:0097472	cyclin-dependent protein kinase activity	4/2130	29/18367	0.438413018380976	0.918807430670254	CDK6/CDK5/CCND3/CDK7	4
GO:0004864	protein phosphatase inhibitor activity	6/2130	46/18367	0.44606648120386	0.918807430670254	PHACTR2/PPP1R10/BOD1/SET/PPP1R14B/LGALS3	6
GO:0061980	regulatory RNA binding	6/2130	46/18367	0.44606648120386	0.918807430670254	KCNQ1OT1/SOX4/PUM2/DICER1/DDX21/HNRNPA1	6
GO:0001848	complement binding	3/2130	21/18367	0.446437666637573	0.918807430670254	CALR/PHB/C1QBP	3
GO:0005385	zinc ion transmembrane transporter activity	3/2130	21/18367	0.446437666637573	0.918807430670254	SLC39A10/SLC39A1/SLC39A7	3
GO:0051428	peptide hormone receptor binding	3/2130	21/18367	0.446437666637573	0.918807430670254	GNAS/PSMC5/PTPN11	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	19/2130	156/18367	0.446698207441791	0.918807430670254	RNMT/TRMT11/COMT/SETD5/DNMT1/SMYD2/DNMT3A/ASH1L/CMTR2/KMT2C/NSD1/COQ5/KMT2A/EMG1/PRMT2/METTL2B/PRMT1/TRMT10A/EHMT1	19
GO:0008170	N-methyltransferase activity	12/2130	97/18367	0.452209027408932	0.918807430670254	RNMT/TRMT11/SETD5/SMYD2/ASH1L/KMT2C/NSD1/HEMK1/KMT2A/PRMT2/PRMT1/EHMT1	12
GO:0004520	endodeoxyribonuclease activity	5/2130	38/18367	0.454910241307728	0.918807430670254	DICER1/RAD50/RPS3/ENDOV/XRCC1	5
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	5/2130	38/18367	0.454910241307728	0.918807430670254	EXOSC7/XRN2/CNOT6L/CNOT1/CNOT7	5
GO:0002161	aminoacyl-tRNA editing activity	2/2130	13/18367	0.455165673680744	0.918807430670254	IARS2/DTD1	2
GO:0005542	folic acid binding	2/2130	13/18367	0.455165673680744	0.918807430670254	SLC19A1/FOLR1	2
GO:0008179	adenylate cyclase binding	2/2130	13/18367	0.455165673680744	0.918807430670254	CAP1/CALM1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/2130	13/18367	0.455165673680744	0.918807430670254	SLC26A2/SLC13A4	2
GO:0008494	translation activator activity	2/2130	13/18367	0.455165673680744	0.918807430670254	PAIP1/RPS27L	2
GO:0016423	tRNA (guanine) methyltransferase activity	2/2130	13/18367	0.455165673680744	0.918807430670254	TRMT11/TRMT10A	2
GO:0016840	carbon-nitrogen lyase activity	2/2130	13/18367	0.455165673680744	0.918807430670254	APMAP/GGCT	2
GO:0019104	DNA N-glycosylase activity	2/2130	13/18367	0.455165673680744	0.918807430670254	MPG/TDG	2
GO:0031404	chloride ion binding	2/2130	13/18367	0.455165673680744	0.918807430670254	CTSC/TDG	2
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	2/2130	13/18367	0.455165673680744	0.918807430670254	PTPMT1/FIG4	2
GO:0042301	phosphate ion binding	2/2130	13/18367	0.455165673680744	0.918807430670254	GNG12/CHST14	2
GO:0045504	dynein heavy chain binding	2/2130	13/18367	0.455165673680744	0.918807430670254	DYNC1LI2/DYNC1I2	2
GO:0051011	microtubule minus-end binding	2/2130	13/18367	0.455165673680744	0.918807430670254	CAMSAP2/MACF1	2
GO:0072542	protein phosphatase activator activity	2/2130	13/18367	0.455165673680744	0.918807430670254	B3GAT3/CALM1	2
GO:0140035	ubiquitination-like modification-dependent protein binding	2/2130	13/18367	0.455165673680744	0.918807430670254	IDE/FAAP20	2
GO:0140299	small molecule sensor activity	2/2130	13/18367	0.455165673680744	0.918807430670254	TMEM63A/PARK7	2
GO:0008235	metalloexopeptidase activity	9/2130	72/18367	0.459130511245387	0.924185547573775	ENPEP/NAALADL2/MMP15/NPEPPS/MMP14/NPEPL1/CPQ/RNPEP/METAP2	9
GO:0019888	protein phosphatase regulator activity	11/2130	89/18367	0.459535064706886	0.924185547573775	PHACTR2/B3GAT3/PPP2R2B/PPP6R2/PPP1R10/BOD1/SET/EIF2AK2/PPP1R14B/LGALS3/CALM1	11
GO:0005343	organic acid:sodium symporter activity	4/2130	30/18367	0.465245481904675	0.932210910138018	SLC38A2/SLC1A3/SLC38A1/SLC10A3	4
GO:0022829	wide pore channel activity	4/2130	30/18367	0.465245481904675	0.932210910138018	GJA5/GJA1/VDAC2/VDAC1	4
GO:0019829	ATPase-coupled cation transmembrane transporter activity	6/2130	47/18367	0.467384564765207	0.934769129530413	ATP2B1/ATP6V1C2/ATP6V1G1/ATP1A1/ATP13A3/ATP6V0E1	6
GO:0004714	transmembrane receptor protein tyrosine kinase activity	15/2130	124/18367	0.472302856873806	0.941985042697696	NRP2/EGFR/EFEMP1/EPHB4/IGF1R/MET/CRIM1/BAZ1B/DDR1/FLT1/NRP1/ERBB2/EIF2AK2/ERBB3/WEE1	15
GO:0005416	amino acid:cation symporter activity	3/2130	22/18367	0.477944440483149	0.941985042697696	SLC38A2/SLC1A3/SLC38A1	3
GO:0005537	mannose binding	3/2130	22/18367	0.477944440483149	0.941985042697696	LMAN1/MANBA/LMAN2	3
GO:0008106	alcohol dehydrogenase (NADP+) activity	3/2130	22/18367	0.477944440483149	0.941985042697696	AKR1B1/AKR7A2/AKR1A1	3
GO:0015645	fatty acid ligase activity	3/2130	22/18367	0.477944440483149	0.941985042697696	SLC27A2/SLC27A3/ACSF2	3
GO:0030742	GTP-dependent protein binding	3/2130	22/18367	0.477944440483149	0.941985042697696	EEA1/RAB38/MRAS	3
GO:0050321	tau-protein kinase activity	3/2130	22/18367	0.477944440483149	0.941985042697696	CDK5/ROCK1/CSNK1D	3
GO:0072349	modified amino acid transmembrane transporter activity	3/2130	22/18367	0.477944440483149	0.941985042697696	SLC16A12/SLC19A1/GJA1	3
GO:0004540	ribonuclease activity	14/2130	116/18367	0.479688177519976	0.943705960855997	RNASET2/SND1/EXOSC7/DICER1/XRN2/ELAC2/RNASEH1/CNOT6L/ENDOV/POP7/CNOT1/DCPS/CNOT7/RPP38	14
GO:0019783	ubiquitin-like protein-specific protease activity	15/2130	125/18367	0.485322253283269	0.953060366954826	USP10/USP22/OTULIN/USP27X/USP40/SENP7/USP48/UCHL3/USP47/USP8/SENP6/USP9X/USP34/USP25/EIF3F	15
GO:0015026	coreceptor activity	6/2130	48/18367	0.488474683583958	0.956142451225011	LRP1/LRP5/ITGAV/ITGB1/TGFBR3/NRP1	6
GO:0016407	acetyltransferase activity	11/2130	91/18367	0.490148667783619	0.956142451225011	CASD1/USP22/NAT10/HADHA/NCOA3/HGSNAT/SAT1/EPC2/NAA10/EPC1/PAFAH1B2	11
GO:0031210	phosphatidylcholine binding	4/2130	31/18367	0.491602699320749	0.956142451225011	CHMP2A/NF1/VDAC2/VDAC1	4
GO:0004065	arylsulfatase activity	2/2130	14/18367	0.495014860595077	0.956142451225011	ARSD/STS	2
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	2/2130	14/18367	0.495014860595077	0.956142451225011	BLNK/SHC1	2
GO:0015373	anion:sodium symporter activity	2/2130	14/18367	0.495014860595077	0.956142451225011	SLC6A4/SLC13A4	2
GO:0015562	efflux transmembrane transporter activity	2/2130	14/18367	0.495014860595077	0.956142451225011	GJA1/ABCB1	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/2130	14/18367	0.495014860595077	0.956142451225011	HSD17B1/HSD17B10	2
GO:0019199	transmembrane receptor protein kinase activity	17/2130	143/18367	0.495444656790155	0.956142451225011	NRP2/EGFR/EFEMP1/EPHB4/IGF1R/MET/CRIM1/BAZ1B/DDR1/FLT1/TGFBR3/LTBP1/NRP1/ERBB2/EIF2AK2/ERBB3/WEE1	17
GO:0004536	deoxyribonuclease activity	7/2130	57/18367	0.496741803110493	0.956142451225011	DICER1/RAD50/RPS3/APEX2/ENDOV/XRCC1/PLD3	7
GO:0005096	GTPase activator activity	54/2130	462/18367	0.497399959794015	0.956142451225011	JUN/ADRB1/IQGAP2/CHM/DOCK9/RASA1/IQGAP1/PSD4/ARHGAP21/MYCBP2/ARHGAP5/HACD3/DENND4C/ARHGAP18/DOCK8/ARHGAP10/CYTH3/EIF2B5/EVI5/SH3BP1/ARFGAP2/LAMTOR4/GNAQ/ARHGAP23/NRP1/VAV3/ELMOD2/GRTP1/CHML/SRGAP1/ERRFI1/RANGRF/NF1/RANBP2/ARHGAP32/FAM13A/TBC1D9B/ARHGAP29/ARFGEF2/RHOU/NUCB2/RAB3GAP1/EEF1D/RABGAP1/RASA2/EIF2B2/EPS8L2/RAPGEF1/EEF1B2/SWAP70/GDI2/ARFGEF1/RAB3GAP2/LAMTOR5	54
GO:0030695	GTPase regulator activity	57/2130	488/18367	0.498358380942925	0.956142451225011	JUN/ADRB1/IQGAP2/CHM/DOCK9/RASA1/IQGAP1/PSD4/ARHGAP21/MYCBP2/ARHGAP5/HACD3/DENND4C/IPO7/ARHGAP18/KRIT1/DOCK8/ARHGAP10/CYTH3/EIF2B5/WASL/EVI5/SH3BP1/ARFGAP2/LAMTOR4/GNAQ/ARHGAP23/NRP1/VAV3/ELMOD2/GRTP1/CHML/SRGAP1/ERRFI1/RANGRF/NF1/RANBP2/ARHGAP32/FAM13A/TBC1D9B/ARHGAP29/ARFGEF2/RHOU/NUCB2/RAB3GAP1/EEF1D/RABGAP1/RASA2/EIF2B2/EPS8L2/RAPGEF1/EEF1B2/SWAP70/GDI2/ARFGEF1/RAB3GAP2/LAMTOR5	57
GO:0060589	nucleoside-triphosphatase regulator activity	57/2130	488/18367	0.498358380942925	0.956142451225011	JUN/ADRB1/IQGAP2/CHM/DOCK9/RASA1/IQGAP1/PSD4/ARHGAP21/MYCBP2/ARHGAP5/HACD3/DENND4C/IPO7/ARHGAP18/KRIT1/DOCK8/ARHGAP10/CYTH3/EIF2B5/WASL/EVI5/SH3BP1/ARFGAP2/LAMTOR4/GNAQ/ARHGAP23/NRP1/VAV3/ELMOD2/GRTP1/CHML/SRGAP1/ERRFI1/RANGRF/NF1/RANBP2/ARHGAP32/FAM13A/TBC1D9B/ARHGAP29/ARFGEF2/RHOU/NUCB2/RAB3GAP1/EEF1D/RABGAP1/RASA2/EIF2B2/EPS8L2/RAPGEF1/EEF1B2/SWAP70/GDI2/ARFGEF1/RAB3GAP2/LAMTOR5	57
GO:0009931	calcium-dependent protein serine/threonine kinase activity	3/2130	23/18367	0.50858355435888	0.968539750014671	PRKCZ/PRKCH/PKN2	3
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	3/2130	23/18367	0.50858355435888	0.968539750014671	CDO1/ETHE1/ADI1	3
GO:0017025	TBP-class protein binding	3/2130	23/18367	0.50858355435888	0.968539750014671	TAF12/TAF11/TAF1B	3
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	3/2130	23/18367	0.50858355435888	0.968539750014671	FAAP20/PRPF8/SQSTM1	3
GO:0019212	phosphatase inhibitor activity	6/2130	49/18367	0.509287506926534	0.968539750014671	PHACTR2/PPP1R10/BOD1/SET/PPP1R14B/LGALS3	6
GO:0000149	SNARE binding	13/2130	110/18367	0.515361590561928	0.976717152924568	SYT7/SLC6A4/VPS52/TMED9/VAMP8/PTPN2/SEC22B/SNCA/STX16/VAMP2/TMED10/NBAS/STX7	13
GO:0001540	amyloid-beta binding	10/2130	84/18367	0.515389493978647	0.976717152924568	LRP1/LRPAP1/ITM2C/IDE/CST3/ITM2B/LDLRAP1/PFDN2/PFDN1/PFDN5	10
GO:0001223	transcription coactivator binding	4/2130	32/18367	0.517400437812846	0.977111628204051	EPAS1/VGLL4/TFAM/RPL23	4
GO:0008175	tRNA methyltransferase activity	4/2130	32/18367	0.517400437812846	0.977111628204051	TRMT11/METTL2B/TYW3/TRMT10A	4
GO:0016247	channel regulator activity	17/2130	145/18367	0.519606995899853	0.979572145313809	RASA1/PRKCZ/FXYD3/VAMP8/GPD1L/SGK3/TSPAN13/PRSS8/YWHAE/RANGRF/SUMO1/AKAP9/SNF8/DLG1/CALM1/NEDD4/STX7	17
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	6/2130	50/18367	0.52977790906362	0.98381900773185	CDKN1C/CCNG2/CCND1/CCND3/CCNG1/HEXIM1	6
GO:0004029	aldehyde dehydrogenase (NAD+) activity	2/2130	15/18367	0.532953503229862	0.98381900773185	ADH5/ALDH7A1	2
GO:0010851	cyclase regulator activity	2/2130	15/18367	0.532953503229862	0.98381900773185	GNAS/CALM1	2
GO:0016805	dipeptidase activity	2/2130	15/18367	0.532953503229862	0.98381900773185	CPQ/SCRN2	2
GO:0042813	Wnt-activated receptor activity	2/2130	15/18367	0.532953503229862	0.98381900773185	LRP5/FZD6	2
GO:0043138	3'-5' DNA helicase activity	2/2130	15/18367	0.532953503229862	0.98381900773185	NAV2/ASCC3	2
GO:0051371	muscle alpha-actinin binding	2/2130	15/18367	0.532953503229862	0.98381900773185	PALLD/PDLIM1	2
GO:0070742	C2H2 zinc finger domain binding	2/2130	15/18367	0.532953503229862	0.98381900773185	SRRM2/EHMT1	2
GO:1901611	phosphatidylglycerol binding	2/2130	15/18367	0.532953503229862	0.98381900773185	MME/GSDMD	2
GO:0016279	protein-lysine N-methyltransferase activity	7/2130	59/18367	0.534646617894358	0.98381900773185	SETD5/SMYD2/ASH1L/KMT2C/NSD1/KMT2A/EHMT1	7
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	7/2130	59/18367	0.534646617894358	0.98381900773185	EXOSC7/XRN2/CNOT6L/APEX2/CNOT1/CNOT7/PLD3	7
GO:0004519	endonuclease activity	15/2130	129/18367	0.536696743814997	0.98381900773185	RNASET2/SND1/REXO4/DICER1/RAD50/ELAC2/G3BP1/RPS3/RNASEH1/APEX2/ENDOV/POP7/XRCC1/N4BP2/RPP38	15
GO:0003707	steroid hormone receptor activity	3/2130	24/18367	0.538249706321434	0.98381900773185	ESRRA/ESRRG/PGRMC2	3
GO:0010857	calcium-dependent protein kinase activity	3/2130	24/18367	0.538249706321434	0.98381900773185	PRKCZ/PRKCH/PKN2	3
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3/2130	24/18367	0.538249706321434	0.98381900773185	CDO1/ETHE1/ADI1	3
GO:0050431	transforming growth factor beta binding	3/2130	24/18367	0.538249706321434	0.98381900773185	ITGAV/TGFBR3/LTBP1	3
GO:0120014	phospholipid transfer activity	3/2130	24/18367	0.538249706321434	0.98381900773185	PRELID1/GLTP/TRIAP1	3
GO:0008080	N-acetyltransferase activity	8/2130	68/18367	0.538990325842673	0.98381900773185	USP22/NAT10/NCOA3/HGSNAT/SAT1/EPC2/NAA10/EPC1	8
GO:0005200	structural constituent of cytoskeleton	12/2130	103/18367	0.539103773609519	0.98381900773185	SPTAN1/PLEC/ANK3/EPB41L3/DSP/ARPC1B/SPTBN1/ADD3/ARPC2/ARPC5/ACTG1/TLN1	12
GO:0019956	chemokine binding	4/2130	33/18367	0.542566132560952	0.988473424699281	ITGAV/ITGB1/ACKR2/HMGB1	4
GO:0008307	structural constituent of muscle	5/2130	42/18367	0.546397808559002	0.991141554144847	ASPH/PLEC/DAG1/CSRP2/TPM4	5
GO:0042562	hormone binding	10/2130	86/18367	0.546584365034074	0.991141554144847	LRP2/EGFR/IGF1R/IDE/CALR/PRLR/SHC1/SEC61B/CTSH/ATP1A1	10
GO:0019955	cytokine binding	16/2130	139/18367	0.552350430118779	0.991141554144847	NRP2/ITGAV/CSF3R/ITGB1/CSF2RA/TGFBR3/ACKR2/LTBP1/LIFR/NRP1/PARK7/PRLR/IL6ST/IFNGR1/HMGB1/IFNAR1	16
GO:0099106	ion channel regulator activity	16/2130	139/18367	0.552350430118779	0.991141554144847	RASA1/PRKCZ/FXYD3/VAMP8/GPD1L/SGK3/TSPAN13/PRSS8/YWHAE/RANGRF/SUMO1/AKAP9/DLG1/CALM1/NEDD4/STX7	16
GO:0016278	lysine N-methyltransferase activity	7/2130	60/18367	0.553167061915573	0.991141554144847	SETD5/SMYD2/ASH1L/KMT2C/NSD1/KMT2A/EHMT1	7
GO:0004843	thiol-dependent deubiquitinase	13/2130	113/18367	0.556187165902081	0.991141554144847	USP10/USP22/OTULIN/USP27X/USP40/USP48/UCHL3/USP47/USP8/USP9X/USP34/USP25/EIF3F	13
GO:0004521	endoribonuclease activity	8/2130	69/18367	0.556232507683202	0.991141554144847	RNASET2/SND1/DICER1/ELAC2/RNASEH1/ENDOV/POP7/RPP38	8
GO:0005518	collagen binding	8/2130	69/18367	0.556232507683202	0.991141554144847	COL14A1/ADGRG1/PCOLCE2/ITGB1/CTSL/DDR1/PPIB/SERPINH1	8
GO:0005516	calmodulin binding	23/2130	201/18367	0.560466495755896	0.991141554144847	ATP2B1/SPTAN1/EGFR/IQGAP2/SYT7/IQGAP1/MYH10/KCNN4/CALD1/EEA1/DDX5/SPTBN1/SLC9A1/ADD3/TJP1/CAMSAP2/EDF1/EWSR1/CAMK2G/PHKB/VAMP2/CNN3/NDUFAF4	23
GO:0005253	anion channel activity	10/2130	87/18367	0.561897376089638	0.991141554144847	GABRE/CLDN4/LRRC8D/FXYD3/APOL1/ANO6/VDAC2/VDAC1/CLIC1/CLIC3	10
GO:0005227	calcium activated cation channel activity	3/2130	25/18367	0.566860054795696	0.991141554144847	TMEM63A/KCNN4/ANO6	3
GO:0008327	methyl-CpG binding	3/2130	25/18367	0.566860054795696	0.991141554144847	DNMT1/CHTOP/PRMT1	3
GO:0043548	phosphatidylinositol 3-kinase binding	4/2130	34/18367	0.567038377489774	0.991141554144847	IGF1R/ATP1A1/CALM1/DNM2	4
GO:0045505	dynein intermediate chain binding	4/2130	34/18367	0.567038377489774	0.991141554144847	DYNC1H1/DYNLL2/DYNLT1/HOOK3	4
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	2/2130	16/18367	0.568888660439668	0.991141554144847	ADH5/ALDH7A1	2
GO:0005521	lamin binding	2/2130	16/18367	0.568888660439668	0.991141554144847	BNIP3L/SUN1	2
GO:0005523	tropomyosin binding	2/2130	16/18367	0.568888660439668	0.991141554144847	CALD1/S100A6	2
GO:0016004	phospholipase activator activity	2/2130	16/18367	0.568888660439668	0.991141554144847	GM2A/PDPK1	2
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/2130	16/18367	0.568888660439668	0.991141554144847	DICER1/ENDOV	2
GO:0035497	cAMP response element binding	2/2130	16/18367	0.568888660439668	0.991141554144847	JUN/CREB3L2	2
GO:0042577	lipid phosphatase activity	2/2130	16/18367	0.568888660439668	0.991141554144847	PLPP3/EPHX2	2
GO:0070402	NADPH binding	2/2130	16/18367	0.568888660439668	0.991141554144847	GRHPR/QDPR	2
GO:0070403	NAD+ binding	2/2130	16/18367	0.568888660439668	0.991141554144847	HADHA/GLUD1	2
GO:0140327	flippase activity	2/2130	16/18367	0.568888660439668	0.991141554144847	ABCB1/ATP10D	2
GO:1990380	Lys48-specific deubiquitinase activity	2/2130	16/18367	0.568888660439668	0.991141554144847	USP27X/USP9X	2
GO:0101005	deubiquitinase activity	13/2130	114/18367	0.569518193627873	0.991141554144847	USP10/USP22/OTULIN/USP27X/USP40/USP48/UCHL3/USP47/USP8/USP9X/USP34/USP25/EIF3F	13
GO:0016830	carbon-carbon lyase activity	6/2130	52/18367	0.569632092465166	0.991141554144847	GGCX/PDXDC1/PISD/DDT/UMPS/ALDOA	6
GO:0031593	polyubiquitin modification-dependent protein binding	6/2130	52/18367	0.569632092465166	0.991141554144847	AGL/FAAP20/VCP/PRPF8/RAD23B/SQSTM1	6
GO:0061135	endopeptidase regulator activity	22/2130	194/18367	0.578365781797499	0.999999999716318	ITIH5/APP/APLP2/SPINT1/SERPINF1/CRIM1/SPINT2/TIMP3/CST3/PEBP1/PRDX5/ANXA2/SERPINH1/TNFAIP8/ROCK1/CAST/PSME3/SNCA/SERPINB1/PRDX3/APH1A/PSME1	22
GO:0005539	glycosaminoglycan binding	26/2130	230/18367	0.586423549125791	0.999999999716318	NRP2/ADAMTS1/CCDC80/FBN1/APP/FSTL1/SOD3/APLP2/ADGRG1/LRPAP1/PCOLCE2/EXTL2/BGN/BMP7/GNS/SMOC1/TGFBR3/NAV2/PTPRF/NRP1/RPL22/C1QBP/PPIA/AAMP/PDCD5/RPL29	26
GO:0050661	NADP binding	6/2130	53/18367	0.588926674847687	0.999999999716318	IDH1/HSD17B1/HIBADH/POR/GRHPR/QDPR	6
GO:0015297	antiporter activity	10/2130	89/18367	0.591864983702046	0.999999999716318	SLC26A2/SLC19A1/SLC25A4/SLC9A1/SLC7A6/SLC35C2/SLC25A5/SLC35D2/SLC35E3/SLC25A6	10
GO:0004867	serine-type endopeptidase inhibitor activity	11/2130	98/18367	0.593068898893489	0.999999999716318	ITIH5/APP/APLP2/SPINT1/SERPINF1/CRIM1/SPINT2/PEBP1/ANXA2/SERPINH1/SERPINB1	11
GO:0097602	cullin family protein binding	3/2130	26/18367	0.59435200724684	0.999999999716318	ANAPC11/DDB1/RNF7	3
GO:0019208	phosphatase regulator activity	12/2130	107/18367	0.594352121106614	0.999999999716318	PHACTR2/B3GAT3/PPP2R2B/PPP6R2/PPP1R10/BOD1/SET/EIF2AK2/PPP1R14B/PPP1R12A/LGALS3/CALM1	12
GO:0008194	UDP-glycosyltransferase activity	16/2130	143/18367	0.599876270836113	0.999999999716318	CHPF/HEXA/EXTL2/GALNT11/GXYLT1/B3GAT3/HEXB/B3GNT3/MGAT3/GALNT18/UGGT2/B4GALT4/B4GALT1/GALNT1/EXT2/ALG5	16
GO:0000400	four-way junction DNA binding	2/2130	17/18367	0.602774613563513	0.999999999716318	YY1/HMGB1	2
GO:0004659	prenyltransferase activity	2/2130	17/18367	0.602774613563513	0.999999999716318	CHM/FDPS	2
GO:0008574	plus-end-directed microtubule motor activity	2/2130	17/18367	0.602774613563513	0.999999999716318	KIF1C/KIF5B	2
GO:0015116	sulfate transmembrane transporter activity	2/2130	17/18367	0.602774613563513	0.999999999716318	SLC26A2/SLC13A4	2
GO:0015174	basic amino acid transmembrane transporter activity	2/2130	17/18367	0.602774613563513	0.999999999716318	SLC38A9/SLC7A6	2
GO:0030275	LRR domain binding	2/2130	17/18367	0.602774613563513	0.999999999716318	KRAS/PAWR	2
GO:0031420	alkali metal ion binding	2/2130	17/18367	0.602774613563513	0.999999999716318	TDG/ATP1A1	2
GO:0042165	neurotransmitter binding	2/2130	17/18367	0.602774613563513	0.999999999716318	IDE/CHRNB1	2
GO:0043024	ribosomal small subunit binding	2/2130	17/18367	0.602774613563513	0.999999999716318	DDX3X/NPM1	2
GO:0070628	proteasome binding	2/2130	17/18367	0.602774613563513	0.999999999716318	ID1/RAD23B	2
GO:0008242	omega peptidase activity	14/2130	126/18367	0.60941161854199	0.999999999716318	USP10/USP22/OTULIN/USP27X/USP40/GGT7/USP48/UCHL3/USP47/USP8/USP9X/USP34/USP25/EIF3F	14
GO:0000217	DNA secondary structure binding	4/2130	36/18367	0.613709004196636	0.999999999716318	YY1/KMT2A/HMGA1/HMGB1	4
GO:0042578	phosphoric ester hydrolase activity	41/2130	366/18367	0.61876775038219	0.999999999716318	PLPP3/PDIA3/PTP4A1/TAB1/PTPRM/DUSP6/DUSP9/CTDSPL/TIMM50/PDE7A/EPHX2/PTPN14/DUSP14/CPPED1/PTPRF/PTPMT1/G6PC3/PTPN12/PTPN2/FIG4/PGP/ENOPH1/SMPDL3A/PHLPP2/TNS3/APEX2/PPM1G/PTPRE/NT5C/CAMK2G/PTPN11/PTPN1/DUSP5/DUSP22/ATP1A1/DLG1/PPP2CB/PPP1CA/PLD3/PPP4C/DUSP1	41
GO:0004709	MAP kinase kinase kinase activity	3/2130	27/18367	0.620681036568928	0.999999999716318	EGFR/MAP3K4/MAP3K2	3
GO:0016866	intramolecular transferase activity	3/2130	27/18367	0.620681036568928	0.999999999716318	PGM3/PMM2/BPGM	3
GO:0030507	spectrin binding	3/2130	27/18367	0.620681036568928	0.999999999716318	ANK3/CAMSAP2/DCTN2	3
GO:0004713	protein tyrosine kinase activity	15/2130	136/18367	0.622146615186032	0.999999999716318	NRP2/EGFR/EFEMP1/EPHB4/IGF1R/MET/CRIM1/BAZ1B/DDR1/FLT1/NRP1/ERBB2/EIF2AK2/ERBB3/WEE1	15
GO:0008509	anion transmembrane transporter activity	35/2130	314/18367	0.625735104746236	0.999999999716318	SLC16A12/GABRE/SLC26A2/SLC38A2/CLDN4/LRRC8D/SLC12A9/SLC19A1/SLC1A3/SLC38A9/SLC22A11/SLC6A4/GJA1/SLC52A1/SLC38A1/FXYD3/SLC25A4/SLC12A4/SLC52A3/APOL1/SLC13A4/SLC52A2/SLC9A1/SLC35B4/SLC25A5/ANO6/SLC35D2/SLC2A8/VDAC2/VDAC1/CLIC1/CLIC3/SLC25A6/MFSD10/SLC2A1	35
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/2130	18/18367	0.634603172271875	0.999999999716318	HSD17B1/HSD17B10	2
GO:0008409	5'-3' exonuclease activity	2/2130	18/18367	0.634603172271875	0.999999999716318	XRN2/PLD3	2
GO:0008569	minus-end-directed microtubule motor activity	2/2130	18/18367	0.634603172271875	0.999999999716318	DYNC1H1/KIFC3	2
GO:0016755	aminoacyltransferase activity	2/2130	18/18367	0.634603172271875	0.999999999716318	TGM2/GGT7	2
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/2130	18/18367	0.634603172271875	0.999999999716318	MARVELD3/STK38	2
GO:0046527	glucosyltransferase activity	2/2130	18/18367	0.634603172271875	0.999999999716318	UGGT2/ALG5	2
GO:0050811	GABA receptor binding	2/2130	18/18367	0.634603172271875	0.999999999716318	ARFGEF2/GABARAPL1	2
GO:0060229	lipase activator activity	2/2130	18/18367	0.634603172271875	0.999999999716318	GM2A/PDPK1	2
GO:0043531	ADP binding	4/2130	37/18367	0.635834632812017	0.999999999716318	MYH10/VCP/ATP1A1/GLUD1	4
GO:0008173	RNA methyltransferase activity	7/2130	65/18367	0.640348023786891	0.999999999716318	RNMT/TRMT11/CMTR2/EMG1/METTL2B/TYW3/TRMT10A	7
GO:0004869	cysteine-type endopeptidase inhibitor activity	6/2130	56/18367	0.643950356019218	0.999999999716318	CST3/PRDX5/TNFAIP8/CAST/SNCA/PRDX3	6
GO:0015101	organic cation transmembrane transporter activity	3/2130	28/18367	0.645818569643678	0.999999999716318	SLC19A3/SLC44A2/ATP13A3	3
GO:0051861	glycolipid binding	3/2130	28/18367	0.645818569643678	0.999999999716318	PSAP/CLN3/GLTP	3
GO:1990756	ubiquitin ligase-substrate adaptor activity	3/2130	28/18367	0.645818569643678	0.999999999716318	PDCD6/ARRDC1/HERPUD1	3
GO:0003730	mRNA 3'-UTR binding	22/2130	201/18367	0.646942501289576	0.999999999716318	FUS/DDX5/HNRNPR/DHX36/PUM2/RPS7/RPL41/CIRBP/RPL5/PABPC4/HNRNPA0/SERBP1/NUDT21/RNPS1/HNRNPU/ZFP36L1/IGF2BP3/UTP23/RBMS1/RBMS2/FXR1/CCT5	22
GO:0004518	nuclease activity	23/2130	210/18367	0.647483632868525	0.999999999716318	RNASET2/SND1/REXO4/EXOSC7/DICER1/XRN2/RAD50/ELAC2/G3BP1/RPS3/RNASEH1/CNOT6L/APEX2/ENDOV/POP7/XRCC1/N4BP2/CNOT1/DCPS/CNOT7/PLD3/DDX1/RPP38	23
GO:0015175	neutral amino acid transmembrane transporter activity	4/2130	38/18367	0.657119855341934	0.999999999716318	SLC38A2/SLC38A9/SLC38A1/SLC43A2	4
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4/2130	38/18367	0.657119855341934	0.999999999716318	SIAH1/PARK7/RNF217/RPS3	4
GO:0140303	intramembrane lipid transporter activity	4/2130	38/18367	0.657119855341934	0.999999999716318	XKR8/ANO6/ABCB1/ATP10D	4
GO:0005548	phospholipid transporter activity	6/2130	57/18367	0.661269009302597	0.999999999716318	XKR8/ANO6/ABCB1/PRELID1/GLTP/TRIAP1	6
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/2130	19/18367	0.664395592165091	0.999999999716318	TGFBR3/LTBP1	2
GO:0035613	RNA stem-loop binding	2/2130	19/18367	0.664395592165091	0.999999999716318	MYH10/DDX3X	2
GO:0008514	organic anion transmembrane transporter activity	20/2130	185/18367	0.665450277145013	0.999999999716318	SLC16A12/SLC26A2/SLC38A2/SLC19A1/SLC1A3/SLC38A9/SLC22A11/GJA1/SLC52A1/SLC38A1/SLC25A4/SLC52A3/SLC52A2/SLC35B4/SLC25A5/SLC35D2/SLC2A8/SLC25A6/MFSD10/SLC2A1	20
GO:0004033	aldo-keto reductase (NADP) activity	3/2130	29/18367	0.669749979404759	0.999999999716318	AKR1B1/AKR7A2/AKR1A1	3
GO:0032452	histone demethylase activity	3/2130	29/18367	0.669749979404759	0.999999999716318	KDM5A/JARID2/KDM5B	3
GO:0035250	UDP-galactosyltransferase activity	3/2130	29/18367	0.669749979404759	0.999999999716318	B3GNT3/B4GALT4/B4GALT1	3
GO:0140457	protein demethylase activity	3/2130	29/18367	0.669749979404759	0.999999999716318	KDM5A/JARID2/KDM5B	3
GO:0004402	histone acetyltransferase activity	4/2130	39/18367	0.67754901055231	0.999999999716318	USP22/NCOA3/EPC2/EPC1	4
GO:0005504	fatty acid binding	4/2130	39/18367	0.67754901055231	0.999999999716318	ADH5/NDUFAB1/GSTP1/PPARG	4
GO:0038024	cargo receptor activity	8/2130	77/18367	0.682517020136607	0.999999999716318	LRP2/LRP1/COLEC12/LGALS3BP/OLR1/ACKR2/FOLR1/DAB2	8
GO:0005085	guanyl-nucleotide exchange factor activity	24/2130	223/18367	0.683173342166917	0.999999999716318	ADRB1/DOCK9/PSD4/MYCBP2/DENND4C/DOCK8/CYTH3/EIF2B5/LAMTOR4/VAV3/RANGRF/ARFGEF2/RHOU/NUCB2/RAB3GAP1/EEF1D/EIF2B2/EPS8L2/RAPGEF1/EEF1B2/SWAP70/ARFGEF1/RAB3GAP2/LAMTOR5	24
GO:0030414	peptidase inhibitor activity	20/2130	187/18367	0.684309619824965	0.999999999716318	ITIH5/APP/APLP2/SPINT1/SERPINF1/CRIM1/GPC3/SPINT2/TIMP3/CST3/PEBP1/PRDX5/ANXA2/SERPINH1/TNFAIP8/ROCK1/CAST/SNCA/SERPINB1/PRDX3	20
GO:0034212	peptide N-acetyltransferase activity	5/2130	49/18367	0.685919594619308	0.999999999716318	USP22/NCOA3/EPC2/NAA10/EPC1	5
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/2130	20/18367	0.692195860927932	0.999999999716318	FOS/REST	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/2130	20/18367	0.692195860927932	0.999999999716318	GLDC/GLUD1	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/2130	20/18367	0.692195860927932	0.999999999716318	CDS1/GNPTAB	2
GO:0019211	phosphatase activator activity	2/2130	20/18367	0.692195860927932	0.999999999716318	B3GAT3/CALM1	2
GO:0042288	MHC class I protein binding	2/2130	20/18367	0.692195860927932	0.999999999716318	BCAP31/VCP	2
GO:0017147	Wnt-protein binding	3/2130	30/18367	0.692472701349213	0.999999999716318	LRP5/WLS/FZD6	3
GO:0015103	inorganic anion transmembrane transporter activity	16/2130	152/18367	0.697709611653255	0.999999999716318	GABRE/SLC26A2/CLDN4/LRRC8D/SLC12A9/SLC22A11/SLC6A4/FXYD3/SLC12A4/APOL1/SLC13A4/ANO6/VDAC2/VDAC1/CLIC1/CLIC3	16
GO:0004866	endopeptidase inhibitor activity	19/2130	180/18367	0.703550288959259	0.999999999716318	ITIH5/APP/APLP2/SPINT1/SERPINF1/CRIM1/SPINT2/TIMP3/CST3/PEBP1/PRDX5/ANXA2/SERPINH1/TNFAIP8/ROCK1/CAST/SNCA/SERPINB1/PRDX3	19
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/2130	10/18367	0.708568821442109	0.999999999716318	RNASEH1	1
GO:0004955	prostaglandin receptor activity	1/2130	10/18367	0.708568821442109	0.999999999716318	PPARG	1
GO:0005384	manganese ion transmembrane transporter activity	1/2130	10/18367	0.708568821442109	0.999999999716318	TMEM165	1
GO:0008519	ammonium transmembrane transporter activity	1/2130	10/18367	0.708568821442109	0.999999999716318	SLC12A4	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/2130	10/18367	0.708568821442109	0.999999999716318	NAE1	1
GO:0015232	heme transmembrane transporter activity	1/2130	10/18367	0.708568821442109	0.999999999716318	PGRMC2	1
GO:0016595	glutamate binding	1/2130	10/18367	0.708568821442109	0.999999999716318	SLC1A3	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/2130	10/18367	0.708568821442109	0.999999999716318	DEGS1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/2130	10/18367	0.708568821442109	0.999999999716318	ADH5	1
GO:0019203	carbohydrate phosphatase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	G6PC3	1
GO:0019531	oxalate transmembrane transporter activity	1/2130	10/18367	0.708568821442109	0.999999999716318	SLC26A2	1
GO:0031419	cobalamin binding	1/2130	10/18367	0.708568821442109	0.999999999716318	MTR	1
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	FIG4	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/2130	10/18367	0.708568821442109	0.999999999716318	DNM2	1
GO:0043208	glycosphingolipid binding	1/2130	10/18367	0.708568821442109	0.999999999716318	PSAP	1
GO:0047760	butyrate-CoA ligase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	ACSF2	1
GO:0050308	sugar-phosphatase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	G6PC3	1
GO:0050786	RAGE receptor binding	1/2130	10/18367	0.708568821442109	0.999999999716318	HMGB1	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	PLA2G15	1
GO:0070008	serine-type exopeptidase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	CPVL	1
GO:0070739	protein-glutamic acid ligase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	TPGS1	1
GO:0070740	tubulin-glutamic acid ligase activity	1/2130	10/18367	0.708568821442109	0.999999999716318	TPGS1	1
GO:0098505	G-rich strand telomeric DNA binding	1/2130	10/18367	0.708568821442109	0.999999999716318	HNRNPA1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/2130	10/18367	0.708568821442109	0.999999999716318	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/2130	10/18367	0.708568821442109	0.999999999716318	GLTP	1
GO:0043177	organic acid binding	14/2130	135/18367	0.711714909717891	0.999999999716318	NR2F2/GLDC/SLC19A1/SLC1A3/HBA1/HBA2/THNSL2/FOLR1/ASS1/HBG2/HBB/PPARG/HBG1/PHYH	14
GO:0008157	protein phosphatase 1 binding	3/2130	31/18367	0.713994487280834	0.999999999716318	PPP1R9A/STAU1/PPP1CA	3
GO:0042910	xenobiotic transmembrane transporter activity	3/2130	31/18367	0.713994487280834	0.999999999716318	SLC19A1/ABCB1/SLC2A1	3
GO:0043015	gamma-tubulin binding	3/2130	31/18367	0.713994487280834	0.999999999716318	DDX3X/CEP57/BLOC1S2	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/2130	41/18367	0.715810512067332	0.999999999716318	COL14A1/COL4A1/COL21A1/COL4A2	4
GO:0061733	peptide-lysine-N-acetyltransferase activity	4/2130	41/18367	0.715810512067332	0.999999999716318	USP22/NCOA3/EPC2/EPC1	4
GO:0001614	purinergic nucleotide receptor activity	2/2130	21/18367	0.718065144537443	0.999999999716318	P2RX4/P2RY6	2
GO:0005243	gap junction channel activity	2/2130	21/18367	0.718065144537443	0.999999999716318	GJA5/GJA1	2
GO:0015662	P-type ion transporter activity	2/2130	21/18367	0.718065144537443	0.999999999716318	ATP2B1/ATP1A1	2
GO:0016502	nucleotide receptor activity	2/2130	21/18367	0.718065144537443	0.999999999716318	P2RX4/P2RY6	2
GO:0019200	carbohydrate kinase activity	2/2130	21/18367	0.718065144537443	0.999999999716318	NAGK/PFKL	2
GO:0051010	microtubule plus-end binding	2/2130	21/18367	0.718065144537443	0.999999999716318	CLIP1/DST	2
GO:0140358	P-type transmembrane transporter activity	2/2130	21/18367	0.718065144537443	0.999999999716318	ATP2B1/ATP1A1	2
GO:0015179	L-amino acid transmembrane transporter activity	6/2130	61/18367	0.725085618916948	0.999999999716318	SLC38A2/SLC1A3/SLC38A9/SLC38A1/SLC43A2/SLC7A6	6
GO:0001222	transcription corepressor binding	3/2130	32/18367	0.73433180274304	0.999999999716318	MTF2/SUZ12/EHMT1	3
GO:0030332	cyclin binding	3/2130	32/18367	0.73433180274304	0.999999999716318	CDK6/XRCC6/CDK5RAP3	3
GO:0004879	nuclear receptor activity	5/2130	52/18367	0.735928693093818	0.999999999716318	NR2F2/NR2F6/ESRRA/ESRRG/PPARG	5
GO:0098531	ligand-activated transcription factor activity	5/2130	52/18367	0.735928693093818	0.999999999716318	NR2F2/NR2F6/ESRRA/ESRRG/PPARG	5
GO:0005496	steroid binding	10/2130	100/18367	0.736743140943166	0.999999999716318	CD81/ESRRA/HSD17B1/OSBPL9/ESRRG/VDAC2/STARD3NL/VDAC1/PGRMC2/ATP1A1	10
GO:0015631	tubulin binding	40/2130	375/18367	0.738329665120214	0.999999999716318	CLIP1/DST/DAG1/HOOK2/GJA1/KRIT1/KIF1C/DPYSL2/LRPPRC/MAP1S/ADNP/CAMSAP2/MAP4/EZR/SMC3/RPS3/EML4/DDX3X/TPR/STRBP/PDCD5/CEP350/CEP57/KIFC3/KIF5B/MACF1/SNCA/RABGAP1/EML2/RMDN1/BLOC1S2/UXT/TPGS1/ALDOA/HOOK3/MAP7D3/GABARAPL1/CNN3/DNM2/CCT5	40
GO:0005355	glucose transmembrane transporter activity	2/2130	22/18367	0.742077214942872	0.999999999716318	SLC2A8/SLC2A1	2
GO:0015149	hexose transmembrane transporter activity	2/2130	22/18367	0.742077214942872	0.999999999716318	SLC2A8/SLC2A1	2
GO:0016881	acid-amino acid ligase activity	2/2130	22/18367	0.742077214942872	0.999999999716318	PPCS/TPGS1	2
GO:0017075	syntaxin-1 binding	2/2130	22/18367	0.742077214942872	0.999999999716318	SLC6A4/VAMP2	2
GO:0030021	extracellular matrix structural constituent conferring compression resistance	2/2130	22/18367	0.742077214942872	0.999999999716318	BGN/TUFT1	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/2130	11/18367	0.742384173096971	0.999999999716318	HSF1	1
GO:0004143	diacylglycerol kinase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	DGKD	1
GO:0004596	peptide alpha-N-acetyltransferase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	NAA10	1
GO:0004954	prostanoid receptor activity	1/2130	11/18367	0.742384173096971	0.999999999716318	PPARG	1
GO:0005247	voltage-gated chloride channel activity	1/2130	11/18367	0.742384173096971	0.999999999716318	ANO6	1
GO:0005436	sodium:phosphate symporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC20A2	1
GO:0008503	benzodiazepine receptor activity	1/2130	11/18367	0.742384173096971	0.999999999716318	GABRE	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/2130	11/18367	0.742384173096971	0.999999999716318	PKIB	1
GO:0010485	H4 histone acetyltransferase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	USP22	1
GO:0015378	sodium:chloride symporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC9A1	1
GO:0016832	aldehyde-lyase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	ALDOA	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/2130	11/18367	0.742384173096971	0.999999999716318	GLCE	1
GO:0019855	calcium channel inhibitor activity	1/2130	11/18367	0.742384173096971	0.999999999716318	CALM1	1
GO:0022889	serine transmembrane transporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC38A2	1
GO:0035197	siRNA binding	1/2130	11/18367	0.742384173096971	0.999999999716318	DICER1	1
GO:0035252	UDP-xylosyltransferase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	GXYLT1	1
GO:0035673	oligopeptide transmembrane transporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	GJA1	1
GO:0042285	xylosyltransferase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	GXYLT1	1
GO:0043522	leucine zipper domain binding	1/2130	11/18367	0.742384173096971	0.999999999716318	PAWR	1
GO:0048407	platelet-derived growth factor binding	1/2130	11/18367	0.742384173096971	0.999999999716318	COL4A1	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	1/2130	11/18367	0.742384173096971	0.999999999716318	PLA2G15	1
GO:0102545	phosphatidyl phospholipase B activity	1/2130	11/18367	0.742384173096971	0.999999999716318	PLA2G15	1
GO:0140161	monocarboxylate:sodium symporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC10A3	1
GO:1901474	azole transmembrane transporter activity	1/2130	11/18367	0.742384173096971	0.999999999716318	SLC19A3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	23/2130	222/18367	0.748616947734928	0.999999999716318	CASD1/USP22/NMT1/CPT2/ALAS2/NAT10/TGM2/HADHA/GPAM/NCOA3/HGSNAT/LPCAT3/HADHB/PLA2G15/OSGEP/SPTSSA/SAT1/EPC2/NAA10/ZDHHC4/EPC1/PAFAH1B2/ALAS1	23
GO:0005246	calcium channel regulator activity	4/2130	43/18367	0.750620050007962	0.999999999716318	SGK3/TSPAN13/YWHAE/CALM1	4
GO:0016746	acyltransferase activity	26/2130	250/18367	0.752243655282259	0.999999999716318	CASD1/USP22/NMT1/CPT2/ALAS2/NAT10/TGM2/HADHA/GPAM/NCOA3/GGT7/HGSNAT/LPCAT3/HADHB/PLA2G15/OSGEP/KMT2C/SPTSSA/SAT1/EPC2/NAA10/ZDHHC4/EPC1/PDHX/PAFAH1B2/ALAS1	26
GO:0001530	lipopolysaccharide binding	3/2130	33/18367	0.753508369761249	0.999999999716318	HSPD1/PSMB4/HMGB1	3
GO:0008200	ion channel inhibitor activity	3/2130	33/18367	0.753508369761249	0.999999999716318	RASA1/CALM1/NEDD4	3
GO:0051427	hormone receptor binding	3/2130	33/18367	0.753508369761249	0.999999999716318	GNAS/PSMC5/PTPN11	3
GO:0004222	metalloendopeptidase activity	11/2130	111/18367	0.753667516610435	0.999999999716318	ADAMTS1/ADAMTS6/MME/IDE/MMP15/AFG3L2/MMP14/YME1L1/ECE2/PMPCA/PMPCB	11
GO:0015370	solute:sodium symporter activity	7/2130	73/18367	0.757019103093642	0.999999999716318	SLC38A2/SLC1A3/SLC6A4/SLC38A1/SLC20A2/SLC13A4/SLC10A3	7
GO:0004529	exodeoxyribonuclease activity	2/2130	23/18367	0.764314706427062	0.999999999716318	APEX2/PLD3	2
GO:0008483	transaminase activity	2/2130	23/18367	0.764314706427062	0.999999999716318	BCAT2/GFPT1	2
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/2130	23/18367	0.764314706427062	0.999999999716318	APEX2/PLD3	2
GO:0008374	O-acyltransferase activity	5/2130	54/18367	0.765882333425677	0.999999999716318	CASD1/CPT2/GPAM/LPCAT3/PLA2G15	5
GO:0005254	chloride channel activity	7/2130	74/18367	0.769469984777271	0.999999999716318	GABRE/CLDN4/FXYD3/APOL1/ANO6/CLIC1/CLIC3	7
GO:0008017	microtubule binding	28/2130	271/18367	0.770439016764677	0.999999999716318	CLIP1/DST/HOOK2/KRIT1/KIF1C/DPYSL2/LRPPRC/MAP1S/CAMSAP2/MAP4/EZR/RPS3/EML4/STRBP/CEP350/CEP57/KIFC3/KIF5B/MACF1/SNCA/EML2/RMDN1/UXT/TPGS1/HOOK3/MAP7D3/CNN3/DNM2	28
GO:0015020	glucuronosyltransferase activity	3/2130	34/18367	0.771553852884294	0.999999999716318	CHPF/B3GAT3/EXT2	3
GO:0016248	channel inhibitor activity	3/2130	34/18367	0.771553852884294	0.999999999716318	RASA1/CALM1/NEDD4	3
GO:0005165	neurotrophin receptor binding	1/2130	12/18367	0.772277489249916	0.999999999716318	SHC1	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/2130	12/18367	0.772277489249916	0.999999999716318	APEX2	1
GO:0015269	calcium-activated potassium channel activity	1/2130	12/18367	0.772277489249916	0.999999999716318	KCNN4	1
GO:0030955	potassium ion binding	1/2130	12/18367	0.772277489249916	0.999999999716318	ATP1A1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/2130	12/18367	0.772277489249916	0.999999999716318	P4HB	1
GO:0042166	acetylcholine binding	1/2130	12/18367	0.772277489249916	0.999999999716318	CHRNB1	1
GO:0043176	amine binding	1/2130	12/18367	0.772277489249916	0.999999999716318	SLC6A4	1
GO:0051378	serotonin binding	1/2130	12/18367	0.772277489249916	0.999999999716318	SLC6A4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/2130	12/18367	0.772277489249916	0.999999999716318	USP27X	1
GO:0015171	amino acid transmembrane transporter activity	8/2130	84/18367	0.772554535182826	0.999999999716318	SLC38A2/SLC1A3/SLC38A9/SLC16A2/SLC38A1/SLC43A2/SLC7A6/SLC38A10	8
GO:0015294	solute:cation symporter activity	10/2130	104/18367	0.779822202800542	0.999999999716318	SLC38A2/SLC12A9/SLC1A3/SLC6A4/SLC38A1/SLC20A2/SLC12A4/SLC13A4/SLC25A3/SLC10A3	10
GO:0030170	pyridoxal phosphate binding	5/2130	55/18367	0.779859724707201	0.999999999716318	GLDC/THNSL2/ALAS2/PDXDC1/ALAS1	5
GO:0140223	general transcription initiation factor activity	4/2130	45/18367	0.782056614949784	0.999999999716318	TAF12/TAF11/TAF3/UBTF	4
GO:0000030	mannosyltransferase activity	2/2130	24/18367	0.784866070073029	0.999999999716318	DPY19L1/TMTC3	2
GO:0008171	O-methyltransferase activity	2/2130	24/18367	0.784866070073029	0.999999999716318	COMT/CMTR2	2
GO:0015145	monosaccharide transmembrane transporter activity	2/2130	24/18367	0.784866070073029	0.999999999716318	SLC2A8/SLC2A1	2
GO:0016769	transferase activity, transferring nitrogenous groups	2/2130	24/18367	0.784866070073029	0.999999999716318	BCAT2/GFPT1	2
GO:0008237	metallopeptidase activity	19/2130	190/18367	0.786688994394198	0.999999999716318	ADAMTS1/ADAMTS6/ENPEP/MME/NAALADL2/IDE/MMP15/AFG3L2/NPEPPS/MMP14/NPEPL1/CPQ/YME1L1/RNPEP/ECE2/PMPCA/METAP2/PMPCB/EIF3F	19
GO:0005201	extracellular matrix structural constituent	17/2130	172/18367	0.792534379220619	0.999999999716318	COL14A1/LAMA5/FBN2/FBN1/LAMC1/FRAS1/LAMB1/COL4A1/VWA1/FBLN1/EFEMP1/BGN/TINAGL1/COL21A1/TUFT1/LTBP1/COL4A2	17
GO:0070279	vitamin B6 binding	5/2130	56/18367	0.793184172617787	0.999999999716318	GLDC/THNSL2/ALAS2/PDXDC1/ALAS1	5
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/2130	13/18367	0.79870347388068	0.999999999716318	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/2130	13/18367	0.79870347388068	0.999999999716318	HSPD1	1
GO:0008195	phosphatidate phosphatase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	PLPP3	1
GO:0008253	5'-nucleotidase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	NT5C	1
GO:0008417	fucosyltransferase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	FUT8	1
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	1/2130	13/18367	0.79870347388068	0.999999999716318	SLC10A3	1
GO:0015385	sodium:proton antiporter activity	1/2130	13/18367	0.79870347388068	0.999999999716318	SLC9A1	1
GO:0016594	glycine binding	1/2130	13/18367	0.79870347388068	0.999999999716318	GLDC	1
GO:0022851	GABA-gated chloride ion channel activity	1/2130	13/18367	0.79870347388068	0.999999999716318	GABRE	1
GO:0031432	titin binding	1/2130	13/18367	0.79870347388068	0.999999999716318	CALM1	1
GO:0032036	myosin heavy chain binding	1/2130	13/18367	0.79870347388068	0.999999999716318	MYL12B	1
GO:0034236	protein kinase A catalytic subunit binding	1/2130	13/18367	0.79870347388068	0.999999999716318	EZR	1
GO:0045159	myosin II binding	1/2130	13/18367	0.79870347388068	0.999999999716318	TRIOBP	1
GO:0052650	NADP-retinol dehydrogenase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	AKR1B1	1
GO:0070700	BMP receptor binding	1/2130	13/18367	0.79870347388068	0.999999999716318	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/2130	13/18367	0.79870347388068	0.999999999716318	HSD17B1	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	PTPMT1	1
GO:0140333	glycerophospholipid flippase activity	1/2130	13/18367	0.79870347388068	0.999999999716318	ABCB1	1
GO:0005112	Notch binding	2/2130	25/18367	0.803823114879753	0.999999999716318	AAK1/GALNT11	2
GO:0043394	proteoglycan binding	3/2130	36/18367	0.804393018370848	0.999999999716318	LRP1/CTSL/PTPRF	3
GO:0004896	cytokine receptor activity	9/2130	97/18367	0.806547725026961	0.999999999716318	CSF3R/IL10RB/CSF2RA/ACKR2/LIFR/PRLR/IL6ST/IFNGR1/IFNAR1	9
GO:0019209	kinase activator activity	10/2130	107/18367	0.808646340547555	0.999999999716318	IQGAP1/TAB1/ABI1/CD24/RPLP1/DDX3X/STK3/CALM1/HMGB1/ERBB3	10
GO:0015291	secondary active transmembrane transporter activity	24/2130	240/18367	0.80889287752778	0.999999999716318	SLC16A12/SLC26A2/SLC38A2/SLC12A9/SLC19A1/SLC1A3/SLC22A11/SLC6A4/SLC16A2/SLC38A1/SLC25A4/SLC20A2/SLC12A4/SLC13A4/SLC9A1/SLC7A6/SLC35C2/SLC25A3/SLC25A5/SLC35D2/SLC35E3/SLC10A3/SLC25A6/SLC16A4	24
GO:0005044	scavenger receptor activity	4/2130	47/18367	0.810257711366548	0.999999999716318	LRP1/COLEC12/LGALS3BP/ACKR2	4
GO:0008028	monocarboxylic acid transmembrane transporter activity	5/2130	58/18367	0.817926585207742	0.999999999716318	SLC16A12/SLC16A2/SLC27A2/SLC10A3/SLC16A4	5
GO:0005109	frizzled binding	3/2130	37/18367	0.819265817096627	0.999999999716318	RNF43/ZNRF3/DVL3	3
GO:0016409	palmitoyltransferase activity	3/2130	37/18367	0.819265817096627	0.999999999716318	CPT2/SPTSSA/ZDHHC4	3
GO:0042056	chemoattractant activity	3/2130	37/18367	0.819265817096627	0.999999999716318	MIF/LGALS3/HMGB1	3
GO:0052689	carboxylic ester hydrolase activity	14/2130	147/18367	0.819420068579227	0.999999999716318	IARS2/APMAP/PON2/DTD1/ABHD12/PNPLA4/PLA2G15/BPHL/DPH7/LYPLA1/LYPLA2/LYPLAL1/PAFAH1B2/PGLS	14
GO:0004089	carbonate dehydratase activity	1/2130	14/18367	0.822064136441111	0.999999999716318	CA8	1
GO:0004707	MAP kinase activity	1/2130	14/18367	0.822064136441111	0.999999999716318	MAPK14	1
GO:0005313	L-glutamate transmembrane transporter activity	1/2130	14/18367	0.822064136441111	0.999999999716318	SLC1A3	1
GO:0005451	monovalent cation:proton antiporter activity	1/2130	14/18367	0.822064136441111	0.999999999716318	SLC9A1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/2130	14/18367	0.822064136441111	0.999999999716318	B3GNT3	1
GO:0017110	nucleoside-diphosphatase activity	1/2130	14/18367	0.822064136441111	0.999999999716318	NUDT5	1
GO:0019992	diacylglycerol binding	1/2130	14/18367	0.822064136441111	0.999999999716318	DGKD	1
GO:0030983	mismatched DNA binding	1/2130	14/18367	0.822064136441111	0.999999999716318	TDG	1
GO:0036041	long-chain fatty acid binding	1/2130	14/18367	0.822064136441111	0.999999999716318	PPARG	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/2130	14/18367	0.822064136441111	0.999999999716318	P2RY6	1
GO:0070411	I-SMAD binding	1/2130	14/18367	0.822064136441111	0.999999999716318	CTNNB1	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/2130	14/18367	0.822064136441111	0.999999999716318	FIG4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	4/2130	48/18367	0.823199693108809	0.999999999716318	ASS1/NAPRT/PPCS/TPGS1	4
GO:0070888	E-box binding	4/2130	48/18367	0.823199693108809	0.999999999716318	BHLHE41/HES1/GATA3/PPARG	4
GO:0003777	microtubule motor activity	6/2130	69/18367	0.826154150859593	0.999999999716318	DYNC1H1/KIF1C/SMC3/DYNC1I2/KIFC3/KIF5B	6
GO:0030246	carbohydrate binding	27/2130	271/18367	0.826317068906064	0.999999999716318	LMAN1/GAA/GALNT11/COLEC12/AGL/OS9/OLR1/MAN2A1/MANBA/CALR/GUSB/GANAB/GALNT18/MLEC/CLEC1A/LMAN2/GALNT1/LGALS8/CANX/SLC2A8/UGP2/LGALS3/EMC7/PHYH/ALDOA/RPIA/PFKL	27
GO:0020037	heme binding	13/2130	139/18367	0.831802784656485	0.999999999716318	HBA1/HBA2/PTGES2/CYB5A/THAP4/HBG2/HBB/PGRMC2/HBG1/COX15/CYCS/CYC1/HEBP2	13
GO:0046982	protein heterodimerization activity	33/2130	328/18367	0.832134233300391	0.999999999716318	ADRB1/JAM3/HEXA/P4HB/BHLHE41/TENM3/ITGB1/EPAS1/TAF12/NAE1/DGKD/TPM4/RRAGA/PHB/YWHAE/SMC3/ERBB2/CAV2/TOP2B/MICU2/EXT2/TAF11/RRAGC/TAF3/HSF1/MAFG/TRMT112/ATP1A1/PAFAH1B2/SNX2/ERBB3/RAN/FXR1	33
GO:0016251	RNA polymerase II general transcription initiation factor activity	3/2130	38/18367	0.833164042389887	0.999999999716318	TAF12/TAF11/TAF3	3
GO:0046906	tetrapyrrole binding	14/2130	149/18367	0.834060795421924	0.999999999716318	MTR/HBA1/HBA2/PTGES2/CYB5A/THAP4/HBG2/HBB/PGRMC2/HBG1/COX15/CYCS/CYC1/HEBP2	14
GO:0043539	protein serine/threonine kinase activator activity	4/2130	49/18367	0.835402368530099	0.999999999716318	IQGAP1/DDX3X/STK3/CALM1	4
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/2130	27/18367	0.837326880831582	0.999999999716318	PTPMT1/FIG4	2
GO:0051119	sugar transmembrane transporter activity	2/2130	27/18367	0.837326880831582	0.999999999716318	SLC2A8/SLC2A1	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/2130	27/18367	0.837326880831582	0.999999999716318	ABCB1/ATP10D	2
GO:0032934	sterol binding	5/2130	60/18367	0.840230309841994	0.999999999716318	CD81/OSBPL9/VDAC2/STARD3NL/VDAC1	5
GO:0030295	protein kinase activator activity	9/2130	101/18367	0.842199690572956	0.999999999716318	IQGAP1/ABI1/CD24/RPLP1/DDX3X/STK3/CALM1/HMGB1/ERBB3	9
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/2130	15/18367	0.8427148959562	0.999999999716318	PDE7A	1
GO:0004953	icosanoid receptor activity	1/2130	15/18367	0.8427148959562	0.999999999716318	PPARG	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/2130	15/18367	0.8427148959562	0.999999999716318	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/2130	15/18367	0.8427148959562	0.999999999716318	SLC22A11	1
GO:0008020	G protein-coupled photoreceptor activity	1/2130	15/18367	0.8427148959562	0.999999999716318	OPN3	1
GO:0008252	nucleotidase activity	1/2130	15/18367	0.8427148959562	0.999999999716318	NT5C	1
GO:0008559	ABC-type xenobiotic transporter activity	1/2130	15/18367	0.8427148959562	0.999999999716318	ABCB1	1
GO:0016846	carbon-sulfur lyase activity	1/2130	15/18367	0.8427148959562	0.999999999716318	MGST3	1
GO:0030548	acetylcholine receptor regulator activity	1/2130	15/18367	0.8427148959562	0.999999999716318	CDK5	1
GO:0034483	heparan sulfate sulfotransferase activity	1/2130	15/18367	0.8427148959562	0.999999999716318	HS6ST2	1
GO:0042043	neurexin family protein binding	1/2130	15/18367	0.8427148959562	0.999999999716318	SYTL1	1
GO:0045125	bioactive lipid receptor activity	1/2130	15/18367	0.8427148959562	0.999999999716318	S1PR2	1
GO:0047372	acylglycerol lipase activity	1/2130	15/18367	0.8427148959562	0.999999999716318	ABHD12	1
GO:0048185	activin binding	1/2130	15/18367	0.8427148959562	0.999999999716318	TGFBR3	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/2130	15/18367	0.8427148959562	0.999999999716318	AIFM1	1
GO:0051139	metal ion:proton antiporter activity	1/2130	15/18367	0.8427148959562	0.999999999716318	SLC9A1	1
GO:0071933	Arp2/3 complex binding	1/2130	15/18367	0.8427148959562	0.999999999716318	IQGAP2	1
GO:0099602	neurotransmitter receptor regulator activity	1/2130	15/18367	0.8427148959562	0.999999999716318	CDK5	1
GO:1904680	peptide transmembrane transporter activity	1/2130	15/18367	0.8427148959562	0.999999999716318	GJA1	1
GO:1990825	sequence-specific mRNA binding	1/2130	15/18367	0.8427148959562	0.999999999716318	SSB	1
GO:0070851	growth factor receptor binding	13/2130	141/18367	0.846105276260568	0.999999999716318	APP/EFEMP1/NCSTN/ATXN2/TIMM50/TRIP6/VAV3/SHC1/IL6ST/GATA3/PSEN1/SNX4/SNX2	13
GO:0032451	demethylase activity	3/2130	39/18367	0.846131961709685	0.999999999716318	KDM5A/JARID2/KDM5B	3
GO:0015485	cholesterol binding	4/2130	50/18367	0.846892255289919	0.999999999716318	CD81/VDAC2/STARD3NL/VDAC1	4
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4/2130	50/18367	0.846892255289919	0.999999999716318	TLR3/MAN2A1/MPG/TDG	4
GO:0001664	G protein-coupled receptor binding	29/2130	295/18367	0.85315128693707	0.999999999716318	ITGB4/RNF43/ADRB1/WLS/GNA12/GNAI1/ADM/ZNRF3/HSPA8/GNAI2/GNAQ/GNAS/CNIH4/PSMC5/ITCH/PHB/GNA11/C1QBP/HOMER1/S1PR2/PDCD6IP/STUB1/PTPN11/DVL3/SNX5/CALM1/VPS35/NEDD4/DNM2	29
GO:0042287	MHC protein binding	3/2130	40/18367	0.858214548646674	0.999999999716318	CD81/BCAP31/VCP	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/2130	16/18367	0.860969978323969	0.999999999716318	PURA	1
GO:0003688	DNA replication origin binding	1/2130	16/18367	0.860969978323969	0.999999999716318	HSPD1	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/2130	16/18367	0.860969978323969	0.999999999716318	CAPN1	1
GO:0008191	metalloendopeptidase inhibitor activity	1/2130	16/18367	0.860969978323969	0.999999999716318	TIMP3	1
GO:0008970	phospholipase A1 activity	1/2130	16/18367	0.860969978323969	0.999999999716318	PLA2G15	1
GO:0010181	FMN binding	1/2130	16/18367	0.860969978323969	0.999999999716318	POR	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/2130	16/18367	0.860969978323969	0.999999999716318	SLC1A3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/2130	16/18367	0.860969978323969	0.999999999716318	SLC22A11	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/2130	16/18367	0.860969978323969	0.999999999716318	PIP4K2C	1
GO:0022821	potassium ion antiporter activity	1/2130	16/18367	0.860969978323969	0.999999999716318	SLC9A1	1
GO:0022848	acetylcholine-gated cation-selective channel activity	1/2130	16/18367	0.860969978323969	0.999999999716318	CHRNB1	1
GO:0035173	histone kinase activity	1/2130	16/18367	0.860969978323969	0.999999999716318	BAZ1B	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/2130	16/18367	0.860969978323969	0.999999999716318	SOCS1	1
GO:0050700	CARD domain binding	1/2130	16/18367	0.860969978323969	0.999999999716318	CASP4	1
GO:1990404	protein ADP-ribosylase activity	1/2130	16/18367	0.860969978323969	0.999999999716318	PARP1	1
GO:0046943	carboxylic acid transmembrane transporter activity	15/2130	163/18367	0.861991583364423	0.999999999716318	SLC16A12/SLC26A2/SLC38A2/SLC19A1/SLC1A3/SLC38A9/SLC16A2/SLC27A2/SLC38A1/SLC43A2/SLC7A6/ABCB1/SLC38A10/SLC10A3/SLC16A4	15
GO:0033293	monocarboxylic acid binding	6/2130	73/18367	0.864258476690779	0.999999999716318	NR2F2/PSAP/ADH5/NDUFAB1/GSTP1/PPARG	6
GO:0140101	catalytic activity, acting on a tRNA	11/2130	124/18367	0.864726176282666	0.999999999716318	IARS2/TRMT11/DTD1/TYW5/ELAC2/POP7/METTL2B/TYW3/TRMT10A/DUS1L/RPP38	11
GO:0005231	excitatory extracellular ligand-gated ion channel activity	2/2130	29/18367	0.865562608642256	0.999999999716318	P2RX4/CHRNB1	2
GO:0033612	receptor serine/threonine kinase binding	2/2130	29/18367	0.865562608642256	0.999999999716318	BMP7/MDM2	2
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	2/2130	29/18367	0.865562608642256	0.999999999716318	PLEKHA1/PHLDA3	2
GO:0015293	symporter activity	13/2130	144/18367	0.865779777075373	0.999999999716318	SLC16A12/SLC38A2/SLC12A9/SLC1A3/SLC6A4/SLC16A2/SLC38A1/SLC20A2/SLC12A4/SLC13A4/SLC25A3/SLC10A3/SLC16A4	13
GO:0016597	amino acid binding	4/2130	52/18367	0.867844162489489	0.999999999716318	GLDC/SLC1A3/THNSL2/ASS1	4
GO:1901682	sulfur compound transmembrane transporter activity	4/2130	52/18367	0.867844162489489	0.999999999716318	SLC26A2/GJA1/SLC19A3/SLC13A4	4
GO:0005342	organic acid transmembrane transporter activity	15/2130	164/18367	0.867870163124737	0.999999999716318	SLC16A12/SLC26A2/SLC38A2/SLC19A1/SLC1A3/SLC38A9/SLC16A2/SLC27A2/SLC38A1/SLC43A2/SLC7A6/ABCB1/SLC38A10/SLC10A3/SLC16A4	15
GO:0016874	ligase activity	15/2130	165/18367	0.873550630796427	0.999999999716318	IARS2/ACSS1/ACACA/SLC27A2/NAE1/SLC27A3/ACSF2/ASS1/ITCH/SUCLG1/NAPRT/PPCS/RTCB/TPGS1/MDM2	15
GO:0003951	NAD+ kinase activity	1/2130	17/18367	0.877107188621498	0.999999999716318	DGKD	1
GO:0005005	transmembrane-ephrin receptor activity	1/2130	17/18367	0.877107188621498	0.999999999716318	EPHB4	1
GO:0005149	interleukin-1 receptor binding	1/2130	17/18367	0.877107188621498	0.999999999716318	TRIP6	1
GO:0008525	phosphatidylcholine transporter activity	1/2130	17/18367	0.877107188621498	0.999999999716318	ABCB1	1
GO:0009881	photoreceptor activity	1/2130	17/18367	0.877107188621498	0.999999999716318	OPN3	1
GO:0015095	magnesium ion transmembrane transporter activity	1/2130	17/18367	0.877107188621498	0.999999999716318	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/2130	17/18367	0.877107188621498	0.999999999716318	SLC26A2	1
GO:0016854	racemase and epimerase activity	1/2130	17/18367	0.877107188621498	0.999999999716318	GLCE	1
GO:0030169	low-density lipoprotein particle binding	1/2130	17/18367	0.877107188621498	0.999999999716318	COLEC12	1
GO:0032393	MHC class I receptor activity	1/2130	17/18367	0.877107188621498	0.999999999716318	CTSH	1
GO:0043395	heparan sulfate proteoglycan binding	1/2130	17/18367	0.877107188621498	0.999999999716318	LRP1	1
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/2130	30/18367	0.877926173448901	0.999999999716318	SLC26A2/SLC19A1	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/2130	30/18367	0.877926173448901	0.999999999716318	HSD17B1/HSD17B10	2
GO:0019894	kinesin binding	3/2130	42/18367	0.879904168307228	0.999999999716318	KTN1/SNCA/SPAG9	3
GO:0004674	protein serine/threonine kinase activity	38/2130	386/18367	0.880089078629109	0.999999999716318	AAK1/EGFR/CDK6/PRKDC/LATS2/NRK/MAP3K4/PRKCZ/CDK5/CDC42BPB/TGFBR3/SGK3/SLK/CCND3/LTBP1/BRD4/CPNE3/CDK7/MAP3K2/MAST4/MAP4K3/ROCK1/EIF2AK2/PLK2/LIMK2/PRKCH/EIF2AK4/CAMK2G/CSNK1D/PDPK1/STK3/STK38/SQSTM1/SRPK2/PKN2/TLK1/MAPK14/CSNK1A1	38
GO:0106310	protein serine kinase activity	35/2130	360/18367	0.887981211693716	0.999999999716318	AAK1/CDK6/PRKDC/LATS2/NEK9/NRK/MAP3K4/PRKCZ/CDK5/CDC42BPB/PRPF4B/SGK3/SLK/STK26/CDK7/MAP3K2/MAST4/MAP4K3/ROCK1/EIF2AK2/PLK2/LIMK2/PRKCH/EIF2AK4/CAMK2G/CSNK1D/PDPK1/STK3/TRPM7/STK38/SRPK2/PKN2/TLK1/MAPK14/CSNK1A1	35
GO:0019842	vitamin binding	13/2130	148/18367	0.888862336273608	0.999999999716318	MTR/GLDC/SLC19A1/GGCX/THNSL2/OPN3/ALAS2/PDXDC1/FOLR1/ILVBL/TKT/PHYH/ALAS1	13
GO:0005164	tumor necrosis factor receptor binding	2/2130	31/18367	0.889231806977734	0.999999999716318	TRAF4/SIVA1	2
GO:0016411	acylglycerol O-acyltransferase activity	2/2130	31/18367	0.889231806977734	0.999999999716318	LPCAT3/PLA2G15	2
GO:0071813	lipoprotein particle binding	2/2130	31/18367	0.889231806977734	0.999999999716318	COLEC12/HSPD1	2
GO:0071814	protein-lipid complex binding	2/2130	31/18367	0.889231806977734	0.999999999716318	COLEC12/HSPD1	2
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/2130	18/18367	0.891372130759711	0.999999999716318	FIG4	1
GO:0004550	nucleoside diphosphate kinase activity	1/2130	18/18367	0.891372130759711	0.999999999716318	CMPK1	1
GO:0004708	MAP kinase kinase activity	1/2130	18/18367	0.891372130759711	0.999999999716318	MAPK14	1
GO:0005229	intracellular calcium activated chloride channel activity	1/2130	18/18367	0.891372130759711	0.999999999716318	ANO6	1
GO:0045236	CXCR chemokine receptor binding	1/2130	18/18367	0.891372130759711	0.999999999716318	ITCH	1
GO:0048038	quinone binding	1/2130	18/18367	0.891372130759711	0.999999999716318	NDUFS7	1
GO:0061778	intracellular chloride channel activity	1/2130	18/18367	0.891372130759711	0.999999999716318	ANO6	1
GO:0099095	ligand-gated anion channel activity	1/2130	18/18367	0.891372130759711	0.999999999716318	GABRE	1
GO:1904047	S-adenosyl-L-methionine binding	1/2130	18/18367	0.891372130759711	0.999999999716318	PRMT1	1
GO:0042626	ATPase-coupled transmembrane transporter activity	9/2130	109/18367	0.897854783749123	0.999999999716318	ATP2B1/SLC26A2/ABCB1/TOMM20/ATP6V1C2/ATP6V1G1/ATP1A1/ATP13A3/ATP6V0E1	9
GO:0022839	ion gated channel activity	3/2130	44/18367	0.89858935214134	0.999999999716318	TMEM63A/KCNN4/ANO6	3
GO:0031624	ubiquitin conjugating enzyme binding	2/2130	32/18367	0.899558473926714	0.999999999716318	SIAH1/RNF217	2
GO:0051721	protein phosphatase 2A binding	2/2130	32/18367	0.899558473926714	0.999999999716318	BOD1/PTPN1	2
GO:0005506	iron ion binding	13/2130	151/18367	0.903972901522081	0.999999999716318	HBA1/ACO2/HBA2/CALR/TYW5/CDO1/TET2/ETHE1/ADI1/NFU1/SNCA/PHYH/MSMO1	13
GO:0004890	GABA-A receptor activity	1/2130	19/18367	0.903981938459412	0.999999999716318	GABRE	1
GO:0005003	ephrin receptor activity	1/2130	19/18367	0.903981938459412	0.999999999716318	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/2130	19/18367	0.903981938459412	0.999999999716318	SLC6A4	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/2130	19/18367	0.903981938459412	0.999999999716318	QDPR	1
GO:0016918	retinal binding	1/2130	19/18367	0.903981938459412	0.999999999716318	OPN3	1
GO:0030627	pre-mRNA 5'-splice site binding	1/2130	19/18367	0.903981938459412	0.999999999716318	SNRPC	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/2130	19/18367	0.903981938459412	0.999999999716318	FIG4	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	3/2130	45/18367	0.906913119083594	0.999999999716318	BAZ1B/EIF2AK2/WEE1	3
GO:0016782	transferase activity, transferring sulphur-containing groups	5/2130	68/18367	0.908034313720574	0.999999999716318	TSTD1/TPST2/CHST14/HS6ST2/MOCS2	5
GO:0016779	nucleotidyltransferase activity	11/2130	132/18367	0.91038807310119	0.999999999716318	POLR2J3/POLR2L/CDS1/UGP2/POLR2D/POLR2A/CRCP/POLR2F/NUDT5/POLR3K/CDS2	11
GO:0001972	retinoic acid binding	1/2130	20/18367	0.915128574118963	0.999999999716318	NR2F2	1
GO:0031418	L-ascorbic acid binding	1/2130	20/18367	0.915128574118963	0.999999999716318	PHYH	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/2130	20/18367	0.915128574118963	0.999999999716318	SOCS1	1
GO:0070300	phosphatidic acid binding	1/2130	20/18367	0.915128574118963	0.999999999716318	GSDMD	1
GO:0005319	lipid transporter activity	13/2130	154/18367	0.917346002931004	0.999999999716318	XKR8/SLC27A2/GM2A/SLC27A3/OSBPL9/ANO6/ABCB1/ATP10D/PRELID1/SLC10A3/GLTP/TRIAP1/SLC2A1	13
GO:0016229	steroid dehydrogenase activity	2/2130	34/18367	0.917570261817723	0.999999999716318	HSD17B1/HSD17B10	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/2130	34/18367	0.917570261817723	0.999999999716318	PTPMT1/FIG4	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	3/2130	47/18367	0.921727906720672	0.999999999716318	ADRB1/GABRE/CHRNB1	3
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	1/2130	21/18367	0.924981745598039	0.999999999716318	LPCAT3	1
GO:0005123	death receptor binding	1/2130	21/18367	0.924981745598039	0.999999999716318	CFLAR	1
GO:0008373	sialyltransferase activity	1/2130	21/18367	0.924981745598039	0.999999999716318	ST3GAL6	1
GO:0015125	bile acid transmembrane transporter activity	1/2130	21/18367	0.924981745598039	0.999999999716318	SLC10A3	1
GO:0042887	amide transmembrane transporter activity	2/2130	35/18367	0.925392539269929	0.999999999716318	SLC19A1/GJA1	2
GO:0004620	phospholipase activity	8/2130	104/18367	0.92640912931651	0.999999999716318	PDIA3/PLBD1/ABHD12/PLA2G15/LYPLA1/LYPLA2/LYPLAL1/PLD3	8
GO:0120013	lipid transfer activity	3/2130	48/18367	0.928296454294796	0.999999999716318	PRELID1/GLTP/TRIAP1	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	2/2130	36/18367	0.932510158146345	0.999999999716318	AMPD2/ATIC	2
GO:0005540	hyaluronic acid binding	1/2130	22/18367	0.933691485153047	0.999999999716318	C1QBP	1
GO:0008649	rRNA methyltransferase activity	1/2130	22/18367	0.933691485153047	0.999999999716318	EMG1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/2130	22/18367	0.933691485153047	0.999999999716318	SLC26A2	1
GO:0015464	acetylcholine receptor activity	1/2130	22/18367	0.933691485153047	0.999999999716318	CHRNB1	1
GO:0016917	GABA receptor activity	1/2130	22/18367	0.933691485153047	0.999999999716318	GABRE	1
GO:0140102	catalytic activity, acting on a rRNA	1/2130	22/18367	0.933691485153047	0.999999999716318	EMG1	1
GO:0032813	tumor necrosis factor receptor superfamily binding	3/2130	49/18367	0.934354764235972	0.999999999716318	CFLAR/TRAF4/SIVA1	3
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	PARP1	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	PDE7A	1
GO:0015299	solute:proton antiporter activity	1/2130	23/18367	0.941390429640592	0.999999999716318	SLC9A1	1
GO:0016493	C-C chemokine receptor activity	1/2130	23/18367	0.941390429640592	0.999999999716318	ACKR2	1
GO:0016849	phosphorus-oxygen lyase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	RNASET2	1
GO:0017116	single-stranded DNA helicase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	MCM3	1
GO:0019865	immunoglobulin binding	1/2130	23/18367	0.941390429640592	0.999999999716318	LGALS3	1
GO:0042171	lysophosphatidic acid acyltransferase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	LPCAT3	1
GO:0071617	lysophospholipid acyltransferase activity	1/2130	23/18367	0.941390429640592	0.999999999716318	LPCAT3	1
GO:0005501	retinoid binding	2/2130	38/18367	0.944859997846925	0.999999999716318	NR2F2/OPN3	2
GO:0019840	isoprenoid binding	2/2130	38/18367	0.944859997846925	0.999999999716318	NR2F2/OPN3	2
GO:0001965	G-protein alpha-subunit binding	1/2130	24/18367	0.948195836578312	0.999999999716318	NUCB2	1
GO:0015295	solute:proton symporter activity	1/2130	24/18367	0.948195836578312	0.999999999716318	SLC25A3	1
GO:0019957	C-C chemokine binding	1/2130	24/18367	0.948195836578312	0.999999999716318	ACKR2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/2130	24/18367	0.948195836578312	0.999999999716318	BMP7	1
GO:0008146	sulfotransferase activity	3/2130	52/18367	0.949806091585619	0.999999999716318	TPST2/CHST14/HS6ST2	3
GO:0017046	peptide hormone binding	3/2130	52/18367	0.949806091585619	0.999999999716318	IGF1R/IDE/PRLR	3
GO:0030145	manganese ion binding	4/2130	65/18367	0.952574140464216	0.999999999716318	EXTL2/B4GALT1/GALNT1/NPEPL1	4
GO:1901618	organic hydroxy compound transmembrane transporter activity	3/2130	53/18367	0.954152691776309	0.999999999716318	SLC6A4/SLC10A3/MFSD10	3
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/2130	25/18367	0.954211366649086	0.999999999716318	PDE7A	1
GO:0030247	polysaccharide binding	1/2130	25/18367	0.954211366649086	0.999999999716318	AGL	1
GO:0015144	carbohydrate transmembrane transporter activity	2/2130	40/18367	0.955037811596426	0.999999999716318	SLC2A8/SLC2A1	2
GO:0043014	alpha-tubulin binding	2/2130	40/18367	0.955037811596426	0.999999999716318	EML4/SNCA	2
GO:0031406	carboxylic acid binding	14/2130	176/18367	0.955059580804378	0.999999999716318	NR2F2/GLDC/SLC19A1/SLC1A3/PSAP/THNSL2/ADH5/NDUFAB1/GSTP1/FOLR1/GRHPR/PPARG/PHYH/GLUD1	14
GO:0015085	calcium ion transmembrane transporter activity	10/2130	135/18367	0.958840154968062	0.999999999716318	ATP2B1/ITGAV/TMEM165/P2RX4/CDK5/ANXA2/CUL5/PSEN1/TRPM7/TMEM37	10
GO:0001637	G protein-coupled chemoattractant receptor activity	1/2130	26/18367	0.959528659694416	0.999999999716318	ACKR2	1
GO:0004806	triglyceride lipase activity	1/2130	26/18367	0.959528659694416	0.999999999716318	PNPLA4	1
GO:0004950	chemokine receptor activity	1/2130	26/18367	0.959528659694416	0.999999999716318	ACKR2	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/2130	26/18367	0.959528659694416	0.999999999716318	ZDHHC4	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/2130	26/18367	0.959528659694416	0.999999999716318	ZDHHC4	1
GO:0038187	pattern recognition receptor activity	1/2130	26/18367	0.959528659694416	0.999999999716318	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/2130	26/18367	0.959528659694416	0.999999999716318	SLC26A2	1
GO:0099604	ligand-gated calcium channel activity	1/2130	26/18367	0.959528659694416	0.999999999716318	P2RX4	1
GO:0003774	cytoskeletal motor activity	8/2130	114/18367	0.961402202026105	0.999999999716318	MYH10/DYNC1H1/KIF1C/SMC3/DYNC1I2/KIFC3/KIF5B/PIN1	8
GO:0004683	calmodulin-dependent protein kinase activity	1/2130	27/18367	0.964228728112217	0.999999999716318	CAMK2G	1
GO:0015491	cation:cation antiporter activity	1/2130	27/18367	0.964228728112217	0.999999999716318	SLC9A1	1
GO:0004180	carboxypeptidase activity	2/2130	43/18367	0.967002800862745	0.999999999716318	CPVL/CPQ	2
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	2/2130	43/18367	0.967002800862745	0.999999999716318	SQLE/MSMO1	2
GO:0003953	NAD+ nucleosidase activity	1/2130	28/18367	0.968383188805837	0.999999999716318	TLR3	1
GO:0004629	phospholipase C activity	1/2130	28/18367	0.968383188805837	0.999999999716318	PDIA3	1
GO:0016298	lipase activity	9/2130	129/18367	0.970057438177568	0.999999999716318	PDIA3/PLBD1/ABHD12/PNPLA4/PLA2G15/LYPLA1/LYPLA2/LYPLAL1/PLD3	9
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	2/2130	44/18367	0.970260584135193	0.999999999716318	GABRE/CHRNB1	2
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/2130	29/18367	0.972055352383107	0.999999999716318	QDPR	1
GO:0005262	calcium channel activity	8/2130	119/18367	0.972519781951077	0.999999999716318	ITGAV/P2RX4/CDK5/ANXA2/CUL5/PSEN1/TRPM7/TMEM37	8
GO:0005245	voltage-gated calcium channel activity	2/2130	45/18367	0.973206977858523	0.999999999716318	ITGAV/CDK5	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	40/2130	450/18367	0.974090668800645	0.999999999716318	ZNF208/JUN/CREB3L2/ISL1/DMTF1/NFE2L2/ZFAT/ATMIN/EPAS1/CEBPA/TFAP2A/RREB1/NFAT5/RBPJ/FOS/KLF10/NFATC3/ZNF770/ZNF33A/SOX4/FOSB/YY1/DLX5/EGR1/NFKB1/CEBPD/TBX3/SP1/ESRRG/GATA3/JUND/MAFG/GCM1/FOXC1/RFXANK/GRHL1/TFDP2/ZNF721/TFAP2C/IRF6	40
GO:0016417	S-acyltransferase activity	1/2130	30/18367	0.975301186139459	0.999999999716318	ZDHHC4	1
GO:0140375	immune receptor activity	10/2130	144/18367	0.976684807115358	0.999999999716318	CSF3R/IL10RB/CSF2RA/ACKR2/LIFR/PRLR/IL6ST/CTSH/IFNGR1/IFNAR1	10
GO:0000146	microfilament motor activity	1/2130	31/18367	0.97817016544485	0.999999999716318	MYH10	1
GO:0001216	DNA-binding transcription activator activity	40/2130	456/18367	0.979455960496978	0.999999999716318	ZNF208/JUN/CREB3L2/ISL1/DMTF1/NFE2L2/ZFAT/ATMIN/EPAS1/CEBPA/TFAP2A/RREB1/NFAT5/RBPJ/FOS/KLF10/NFATC3/ZNF770/ZNF33A/SOX4/FOSB/YY1/DLX5/EGR1/NFKB1/CEBPD/TBX3/SP1/ESRRG/GATA3/JUND/MAFG/GCM1/FOXC1/RFXANK/GRHL1/TFDP2/ZNF721/TFAP2C/IRF6	40
GO:0098960	postsynaptic neurotransmitter receptor activity	3/2130	62/18367	0.980153856268201	0.999999999716318	ADRB1/GABRE/CHRNB1	3
GO:0048019	receptor antagonist activity	1/2130	32/18367	0.980706026461564	0.999999999716318	LRPAP1	1
GO:0008081	phosphoric diester hydrolase activity	5/2130	89/18367	0.981974869805474	0.999999999716318	PDIA3/PDE7A/SMPDL3A/APEX2/PLD3	5
GO:0004623	phospholipase A2 activity	1/2130	33/18367	0.982947431623106	0.999999999716318	PLA2G15	1
GO:0005251	delayed rectifier potassium channel activity	1/2130	33/18367	0.982947431623106	0.999999999716318	KCNG1	1
GO:0019239	deaminase activity	1/2130	33/18367	0.982947431623106	0.999999999716318	AMPD2	1
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	25/2130	310/18367	0.983541126625106	0.999999999716318	JUN/NFE2L3/PEG3/BHLHE41/IRX2/NR2F6/TFAP2A/NFATC3/NACC1/YY1/NFKB1/LRRFIP1/TBX3/HES1/ENO1/GATA3/ZFHX3/ETS2/HSF1/REST/PPARG/TGIF1/CREM/TFAP2C/NFIL3	25
GO:0140359	ABC-type transporter activity	2/2130	50/18367	0.984180961735382	0.999999999716318	ABCB1/ATP13A3	2
GO:0001217	DNA-binding transcription repressor activity	25/2130	313/18367	0.985770518103264	0.999999999716318	JUN/NFE2L3/PEG3/BHLHE41/IRX2/NR2F6/TFAP2A/NFATC3/NACC1/YY1/NFKB1/LRRFIP1/TBX3/HES1/ENO1/GATA3/ZFHX3/ETS2/HSF1/REST/PPARG/TGIF1/CREM/TFAP2C/NFIL3	25
GO:0015298	solute:cation antiporter activity	1/2130	35/18367	0.986679617354695	0.999999999716318	SLC9A1	1
GO:0015248	sterol transporter activity	1/2130	36/18367	0.988227316189219	0.999999999716318	OSBPL9	1
GO:0042605	peptide antigen binding	1/2130	36/18367	0.988227316189219	0.999999999716318	DHCR24	1
GO:0030551	cyclic nucleotide binding	1/2130	37/18367	0.989595262101443	0.999999999716318	SLC19A1	1
GO:0071855	neuropeptide receptor binding	1/2130	37/18367	0.989595262101443	0.999999999716318	GNAS	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	11/2130	170/18367	0.991187500713346	0.999999999716318	ASPH/P4HB/DEGS1/TYW5/SQLE/KDM5A/TET2/POR/PHYH/KDM5B/MSMO1	11
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3/2130	71/18367	0.991691057424665	0.999999999716318	TGM2/BTD/HINT1	3
GO:0005230	extracellular ligand-gated ion channel activity	3/2130	73/18367	0.99317864523157	0.999999999716318	GABRE/P2RX4/CHRNB1	3
GO:0004812	aminoacyl-tRNA ligase activity	1/2130	41/18367	0.993652208563338	0.999999999716318	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/2130	41/18367	0.993652208563338	0.999999999716318	IARS2	1
GO:0015081	sodium ion transmembrane transporter activity	9/2130	152/18367	0.994018266324825	0.999999999716318	SLC38A2/SLC1A3/SLC6A4/SLC38A1/SLC20A2/SLC13A4/SLC9A1/SLC10A3/ATP1A1	9
GO:0043178	alcohol binding	4/2130	89/18367	0.994296107431762	0.999999999716318	CD81/VDAC2/STARD3NL/VDAC1	4
GO:0022824	transmitter-gated ion channel activity	2/2130	60/18367	0.994605859481181	0.999999999716318	GABRE/CHRNB1	2
GO:0022835	transmitter-gated channel activity	2/2130	60/18367	0.994605859481181	0.999999999716318	GABRE/CHRNB1	2
GO:0030547	signaling receptor inhibitor activity	1/2130	43/18367	0.995042077839886	0.999999999716318	LRPAP1	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/2130	44/18367	0.995618391646972	0.999999999716318	MAPK14	1
GO:0005126	cytokine receptor binding	19/2130	271/18367	0.995649330072884	0.999999999716318	FERMT2/CFLAR/TIMM50/TRAF4/SIVA1/TGFBR3/TRIP6/LIFR/CNIH4/ITCH/RASL11B/PRLR/SHC1/IL6ST/DDT/GATA3/SNX6/MIF/SPRED2	19
GO:0004252	serine-type endopeptidase activity	10/2130	174/18367	0.997137366091679	0.999999999716318	CTSC/ST14/CTSV/DPP4/MMP14/PRSS8/SEC11A/IMMP2L/CTSH/MBTPS1	10
GO:0048020	CCR chemokine receptor binding	1/2130	48/18367	0.997327376492635	0.999999999716318	CNIH4	1
GO:0008236	serine-type peptidase activity	11/2130	191/18367	0.998006807291436	0.999999999716318	CTSC/ST14/CTSV/CPVL/DPP4/MMP14/PRSS8/SEC11A/IMMP2L/CTSH/MBTPS1	11
GO:0008227	G protein-coupled amine receptor activity	1/2130	51/18367	0.998155480687568	0.999999999716318	ADRB1	1
GO:0017171	serine hydrolase activity	11/2130	195/18367	0.998518233916867	0.999999999716318	CTSC/ST14/CTSV/CPVL/DPP4/MMP14/PRSS8/SEC11A/IMMP2L/CTSH/MBTPS1	11
GO:0042379	chemokine receptor binding	2/2130	72/18367	0.998560047746853	0.999999999716318	CNIH4/ITCH	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	5/2130	125/18367	0.999261878043287	0.999999999716318	AMPD2/TGM2/BTD/HINT1/ATIC	5
GO:0005244	voltage-gated ion channel activity	10/2130	201/18367	0.999649634407922	0.999999999716318	ITGAV/CDK5/KCNG1/TMEM109/ANO6/VDAC2/VDAC1/CLIC1/CLIC3/TMEM37	10
GO:0022832	voltage-gated channel activity	10/2130	201/18367	0.999649634407922	0.999999999716318	ITGAV/CDK5/KCNG1/TMEM109/ANO6/VDAC2/VDAC1/CLIC1/CLIC3/TMEM37	10
GO:0015079	potassium ion transmembrane transporter activity	6/2130	155/18367	0.999828619011547	0.999999999716318	SLC12A9/KCNN4/SLC12A4/SLC9A1/KCNG1/ATP1A1	6
GO:0030594	neurotransmitter receptor activity	3/2130	111/18367	0.999866463256138	0.999999999716318	ADRB1/GABRE/CHRNB1	3
GO:0046873	metal ion transmembrane transporter activity	28/2130	430/18367	0.999874618763668	0.999999999716318	ATP2B1/SLC38A2/ITGAV/SLC12A9/SLC39A10/TUSC3/SLC1A3/SLC6A4/TMEM165/P2RX4/SLC38A1/KCNN4/CDK5/SLC20A2/SLC12A4/SLC13A4/SLC25A37/SLC9A1/ANXA2/KCNG1/SLC39A1/CUL5/PSEN1/SLC10A3/SLC39A7/TRPM7/ATP1A1/TMEM37	28
GO:0008528	G protein-coupled peptide receptor activity	5/2130	147/18367	0.99991087701845	0.999999999716318	LGR4/LGR5/ACKR2/S1PR2/CRCP	5
GO:0001653	peptide receptor activity	5/2130	153/18367	0.999950703535662	0.999999999716318	LGR4/LGR5/ACKR2/S1PR2/CRCP	5
GO:0004497	monooxygenase activity	2/2130	102/18367	0.999951699845288	0.999999999716318	SQLE/MSMO1	2
GO:0005179	hormone activity	3/2130	122/18367	0.999959228572272	0.999999999716318	FBN1/ADM/COPA	3
GO:0005249	voltage-gated potassium channel activity	1/2130	90/18367	0.999985222030493	0.999999999716318	KCNG1	1
GO:0099094	ligand-gated cation channel activity	2/2130	113/18367	0.999986409320301	0.999999999716318	P2RX4/CHRNB1	2
GO:0022836	gated channel activity	17/2130	340/18367	0.999993047264142	0.999999999716318	TMEM63A/GABRE/ITGAV/TMEM150C/TMC5/P2RX4/KCNN4/CDK5/KCNG1/TMEM109/CHRNB1/ANO6/VDAC2/VDAC1/CLIC1/CLIC3/TMEM37	17
GO:0005267	potassium channel activity	2/2130	121/18367	0.999994627527331	0.999999999716318	KCNN4/KCNG1	2
GO:0005216	ion channel activity	24/2130	432/18367	0.999995277660295	0.999999999716318	TMEM63A/GABRE/CLDN4/ITGAV/LRRC8D/TMEM150C/TMC5/P2RX4/KCNN4/FXYD3/CDK5/APOL1/ANXA2/KCNG1/CHRNB1/ANO6/CUL5/PSEN1/VDAC2/VDAC1/CLIC1/CLIC3/TRPM7/TMEM37	24
GO:0015267	channel activity	28/2130	480/18367	0.999995291768355	0.999999999716318	TMEM63A/GABRE/CLDN4/ITGAV/GJA5/LRRC8D/GJA1/TMEM150C/TMC5/P2RX4/KCNN4/FXYD3/CDK5/APOL1/ANXA2/KCNG1/TMEM109/CHRNB1/ANO6/CUL5/PSEN1/VDAC2/VDAC1/CLIC1/CLIC3/TRPM7/MPV17/TMEM37	28
GO:0022803	passive transmembrane transporter activity	28/2130	481/18367	0.999995605470809	0.999999999716318	TMEM63A/GABRE/CLDN4/ITGAV/GJA5/LRRC8D/GJA1/TMEM150C/TMC5/P2RX4/KCNN4/FXYD3/CDK5/APOL1/ANXA2/KCNG1/TMEM109/CHRNB1/ANO6/CUL5/PSEN1/VDAC2/VDAC1/CLIC1/CLIC3/TRPM7/MPV17/TMEM37	28
GO:0015276	ligand-gated ion channel activity	3/2130	143/18367	0.999995934791861	0.999999999716318	GABRE/P2RX4/CHRNB1	3
GO:0022834	ligand-gated channel activity	3/2130	143/18367	0.999995934791861	0.999999999716318	GABRE/P2RX4/CHRNB1	3
GO:0022843	voltage-gated cation channel activity	3/2130	143/18367	0.999995934791861	0.999999999716318	ITGAV/CDK5/KCNG1	3
GO:0008083	growth factor activity	4/2130	162/18367	0.999996385412825	0.999999999716318	GRN/EFEMP1/BMP7/NENF	4
GO:0005125	cytokine activity	8/2130	235/18367	0.999998545627378	0.999999999716318	GRN/BMP7/CMTM8/AIMP1/THNSL2/FAM3B/MIF/HMGB1	8
GO:0005261	cation channel activity	13/2130	335/18367	0.999999882930468	0.999999999716318	TMEM63A/ITGAV/P2RX4/KCNN4/CDK5/ANXA2/KCNG1/CHRNB1/ANO6/CUL5/PSEN1/TRPM7/TMEM37	13
GO:0003823	antigen binding	2/2130	171/18367	0.999999985046019	0.999999999716318	DHCR24/TSPAN4	2
GO:0030546	signaling receptor activator activity	21/2130	495/18367	0.999999998441741	0.999999999716318	FBN1/APP/GRN/LRPAP1/EFEMP1/SEMA6A/BMP7/SEMA6D/CMTM8/AIMP1/SEMA3F/THNSL2/ADM/CDK5/NENF/FAM3B/DPP4/COPA/MIF/LGALS3/HMGB1	21
GO:0048018	receptor ligand activity	19/2130	487/18367	0.999999999716318	0.999999999716318	FBN1/GRN/LRPAP1/EFEMP1/SEMA6A/BMP7/SEMA6D/CMTM8/AIMP1/SEMA3F/THNSL2/ADM/NENF/FAM3B/DPP4/COPA/MIF/LGALS3/HMGB1	19