ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	50/1188	182/18367	6.2230050815374e-19	6.21055907137432e-16	RPS29/RPL37A/ISG15/RPS17/RPS21/RPSA/RPS18/MRPL1/RPS4Y1/RPL23/RPS27/MRPL15/MRPS21/RPL31/MRPS33/RPLP0/RPL36/RPL27A/RPS23/RPS12/MRPS15/RPS28/RPS5/MRPL51/MRPS34/RPLP2/MRPL9/MRPL20/RPS14/MRPL46/MRPL52/RPL35/RPL5/MRPL19/RPL37/MRPS6/MRPL3/RPS27A/RPL18/RPS7/MRPL12/MRPL27/RPS16/MRPS7/MRPL43/MRPL21/MRPL4/RPS3/RPL10A/MRPL34	50
GO:0009055	electron transfer activity	34/1188	126/18367	4.5988392998763e-13	2.29482081063827e-10	GLDC/CYBA/CYBB/NCF2/ADH5/NCF1/AKR1B1/DEGS1/ALDH2/CYB5A/ASPH/UQCR10/NDUFB7/NDUFS5/COX4I1/NDUFA6/ETFA/NDUFC2/FDX1/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/CYCS/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/UQCR11/COX6A1	34
GO:0023026	MHC class II protein complex binding	15/1188	27/18367	1.10688404783429e-11	3.59533232116569e-09	B2M/HSP90AB1/HLA-DPA1/HLA-DRA/HSP90AA1/HLA-DRB1/HLA-DPB1/CD74/PKM/HLA-DMA/HLA-DQA1/YWHAE/HSPA8/HLA-DQA2/HLA-DMB	15
GO:0023023	MHC protein complex binding	17/1188	36/18367	1.44101495838304e-11	3.59533232116569e-09	B2M/HSP90AB1/HLA-DPA1/HLA-DRA/HSP90AA1/HLA-DRB1/HLA-DPB1/CD74/PKM/LILRB2/HLA-DMA/HLA-DQA1/LILRB1/YWHAE/HSPA8/HLA-DQA2/HLA-DMB	17
GO:0045296	cadherin binding	55/1188	332/18367	1.01353729186234e-10	2.02302043455724e-08	CDH1/EGFR/KRT18/ITGA6/LDHA/COBLL1/CALD1/ALDOA/DOCK9/ANK3/S100P/HSP90AB1/TJP1/TRIM29/CTNNAL1/MPP7/PDLIM1/LIMA1/CNN3/PPFIBP1/PRDX1/ITGB1/BSG/FNBP1L/IDH1/STAT1/DLG1/FXYD5/HSPA5/EFHD2/FLNA/BZW2/PAICS/PSMB6/CD46/RAN/RUVBL1/ATIC/WASF2/SERBP1/RANBP1/PKM/TXNDC9/PARK7/ENO1/EIF5/SH3GLB2/PRDX6/VASP/SND1/NOP56/YWHAE/TAGLN2/HSPA8/CD2AP	55
GO:0033218	amide binding	59/1188	400/18367	2.24792895763395e-09	3.73905516619781e-07	HLA-B/HLA-A/CTSV/ENPEP/MME/HLA-C/SLC40A1/FOLR1/SLC19A1/PTGES/HSP90AB1/HLA-E/DHCR24/IGF1R/PRLR/PPIC/HLA-DPA1/ACBD6/HLA-DRA/DBI/NFKBIA/ITM2C/APOE/HLA-F/C1QA/CD14/HLA-DRB1/PPIB/LRPAP1/HLA-DPB1/CLTA/CST3/ECI2/PFDN5/CRIP1/CD74/DLD/SRP14/TREM2/FKBP3/LILRB2/TAP1/CALR/PPIA/TYMS/HLA-DQA1/TLR2/KDELR1/TNPO1/ANPEP/ACBD3/TAPBP/KDELR2/VDAC1/LRP1/SORL1/ACADVL/FKBP2/NUP214	59
GO:0008137	NADH dehydrogenase (ubiquinone) activity	15/1188	42/18367	2.4964061101164e-08	3.55916185413738e-06	NDUFB7/NDUFS5/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	15
GO:0050136	NADH dehydrogenase (quinone) activity	15/1188	43/18367	3.60542241684443e-08	4.49776446501342e-06	NDUFB7/NDUFS5/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	15
GO:0003954	NADH dehydrogenase activity	15/1188	45/18367	7.25744859298283e-08	7.24293369579687e-06	NDUFB7/NDUFS5/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	15
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	15/1188	45/18367	7.25744859298283e-08	7.24293369579687e-06	NDUFB7/NDUFS5/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	15
GO:0016209	antioxidant activity	21/1188	86/18367	8.93714193593763e-08	8.02960178024515e-06	MGST3/SOD3/GPX8/SOD2/PRDX4/SOD1/PTGES/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/GSTO1/PRDX3/PARK7/PRDX6/GLRX/GPX3	21
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	19/1188	72/18367	9.65483179989397e-08	8.02960178024515e-06	CYB5A/UQCR10/NDUFB7/NDUFS5/COX4I1/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/COX6A1	19
GO:0042277	peptide binding	47/1188	321/18367	1.20706775836268e-07	9.2665663295843e-06	HLA-B/HLA-A/CTSV/ENPEP/MME/HLA-C/SLC40A1/PTGES/HSP90AB1/HLA-E/DHCR24/IGF1R/PRLR/PPIC/HLA-DPA1/HLA-DRA/NFKBIA/ITM2C/APOE/HLA-F/C1QA/CD14/HLA-DRB1/PPIB/LRPAP1/HLA-DPB1/CLTA/CST3/PFDN5/CRIP1/CD74/SRP14/TREM2/LILRB2/TAP1/CALR/PPIA/HLA-DQA1/TLR2/KDELR1/TNPO1/ANPEP/TAPBP/KDELR2/LRP1/SORL1/NUP214	47
GO:0016651	oxidoreductase activity, acting on NAD(P)H	21/1188	88/18367	1.36638811153367e-07	9.74039525221857e-06	CYBA/CYBB/NCF2/NCF1/DCXR/NDUFB7/NDUFS5/NDUFA6/NDUFC2/CYB5R1/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	21
GO:0042605	peptide antigen binding	13/1188	36/18367	1.84908508095649e-07	1.23025794052972e-05	HLA-B/HLA-A/HLA-C/HLA-E/DHCR24/HLA-DPA1/HLA-DRA/HLA-F/HLA-DRB1/HLA-DPB1/TAP1/HLA-DQA1/TAPBP	13
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	16/1188	57/18367	3.9306201007877e-07	2.45172428786633e-05	DCXR/NDUFB7/NDUFS5/NDUFA6/NDUFC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4	16
GO:0005178	integrin binding	27/1188	144/18367	4.86634010104057e-07	2.85682789461087e-05	FBN1/LAMA5/EGFR/LAMB1/FBLN1/ITGB4/FERMT1/JAM3/ISG15/ITGB5/FERMT2/PLPP3/ITGB8/P4HB/ITGB1/PTN/LCP1/CD9/DST/CALR/IGF2/PPIA/TSPAN4/UTRN/ICAM3/SYK/LYN	27
GO:0004298	threonine-type endopeptidase activity	8/1188	14/18367	6.32665870512615e-07	3.50778077095328e-05	PSMB9/PSMB8/PSMB2/PSMB1/PSMB6/PSMB5/PSMB7/PSMB4	8
GO:0019843	rRNA binding	17/1188	68/18367	1.04336935443322e-06	5.48043481960188e-05	RPS18/RPS4Y1/RPL23/NPM1/RPLP0/RPS5/MRPL20/RPS14/RPL5/MDM2/RPL37/MRPS6/BRIX1/MRPS7/IMP3/RPS3/CIRBP	17
GO:0044389	ubiquitin-like protein ligase binding	44/1188	316/18367	1.23829398634546e-06	6.17908699186386e-05	EGFR/CXCR4/ISG15/HSPD1/LAPTM5/HSP90AB1/ERBB3/RPL23/NFKBIA/HSP90AA1/STAT1/TUBB/TPI1/CEBPB/HSPA5/VCP/BAG2/PSMD1/UBE2L6/PRKACB/UBB/SLC25A5/CCT2/TUBA1B/PSMA3/PA2G4/LRPPRC/RPL5/MDM2/TXNIP/TRIOBP/RPS27A/PRDX6/NEDD8/JAK1/CALR/YWHAE/HSPA8/JUN/PARP9/GABARAPL1/TNFRSF1B/CCNB1/LYN	44
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	15/1188	55/18367	1.35678484823869e-06	6.44795846924862e-05	MGST3/GPX8/PRDX4/PTGES/PRDX2/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/PRDX3/PARK7/PRDX6/GPX3	15
GO:0042288	MHC class I protein binding	9/1188	20/18367	1.6838480027615e-06	7.6385468488908e-05	HLA-E/TUBB4B/TUBB/PILRA/VCP/LILRB2/TAP1/LILRB1/TAPBP	9
GO:0051082	unfolded protein binding	23/1188	122/18367	3.04984885445819e-06	0.000132336919858664	SERPINH1/HSPD1/LMAN1/HSP90B1/HSP90AB1/HSPE1/TUBB4B/NPM1/ST13/HSP90AA1/HSPA5/PPIB/DNAJB4/CCT2/AFG3L2/PFDN5/SIL1/NUDCD2/CALR/PPIA/TTC1/TAPBP/HSPA8	23
GO:0031625	ubiquitin protein ligase binding	40/1188	297/18367	8.4487211129777e-06	0.000351325986281323	EGFR/CXCR4/ISG15/HSPD1/LAPTM5/HSP90AB1/ERBB3/RPL23/NFKBIA/HSP90AA1/TUBB/TPI1/HSPA5/VCP/BAG2/PSMD1/UBE2L6/PRKACB/UBB/SLC25A5/CCT2/TUBA1B/PSMA3/PA2G4/LRPPRC/RPL5/MDM2/TXNIP/TRIOBP/RPS27A/PRDX6/NEDD8/JAK1/CALR/YWHAE/HSPA8/JUN/GABARAPL1/TNFRSF1B/LYN	40
GO:0003779	actin binding	53/1188	440/18367	9.02434554871887e-06	0.000360251874304857	EGFR/MYH10/SYNE2/DAG1/SLC6A4/FERMT1/COBLL1/CALD1/CXCR4/SORBS1/ALDOA/TMSB4X/PAWR/S100A4/CTNNAL1/FERMT2/SCIN/TMSB10/DSTN/PDLIM1/LIMA1/LSP1/RAI14/AIF1/CNN3/COTL1/MYO7A/P4HB/ITGB1/LCP1/GBP1/FXYD5/ARPC3/FLNA/EPS8/GMFG/ARPC5L/WASF2/MSN/MARCKSL1/DST/TRIOBP/MYO1G/VASP/WASL/PHACTR2/ADD3/ABI3/FMNL1/UTRN/IQGAP2/WIPF1/MYO1F	53
GO:0004601	peroxidase activity	13/1188	51/18367	1.53343278798619e-05	0.000588602277850084	MGST3/GPX8/PRDX4/PTGES/PRDX2/PRDX1/PRDX5/GPX1/GSTP1/GPX4/PRDX3/PRDX6/GPX3	13
GO:0015399	primary active transmembrane transporter activity	27/1188	181/18367	4.06729021956687e-05	0.00148644115998783	SLC26A2/ATP6V1C2/ATP2B1/CYB5A/UQCR10/ATP6V1F/NDUFB7/NDUFS5/COX4I1/NDUFA6/ATP2B4/NDUFC2/TAP1/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/TAPBP/NDUFA5/NDUFS3/NDUFS8/ATP6V1E1/NDUFV2/NDUFA4/COX6A1	27
GO:0004602	glutathione peroxidase activity	8/1188	22/18367	4.22230975573605e-05	0.00148644115998783	MGST3/GPX8/PTGES/GPX1/GSTP1/GPX4/PRDX6/GPX3	8
GO:0043236	laminin binding	9/1188	28/18367	4.31931799996463e-05	0.00148644115998783	BCAM/ITGA6/DAG1/TINAGL1/CTSS/RPSA/GPC1/ITGB1/LGALS3	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	13/1188	57/18367	5.4849835613558e-05	0.0018246711980777	P4HB/PDIA6/PDIA4/IFI30/PGK1/DLD/GSTO1/PRDX3/GLRX5/GLRX/ERO1A/TXN2/SCO2	13
GO:0097110	scaffold protein binding	14/1188	67/18367	8.00989698185824e-05	0.00257867006061114	DSP/KRT18/KRT8/DYNLL2/HSP90AA1/VIM/TREM1/ATP2B4/IL6ST/TREM2/PARK7/YWHAE/SYK/LYN	14
GO:0061134	peptidase regulator activity	31/1188	230/18367	8.31263272307236e-05	0.00259250233050819	ITIH5/CRIM1/FBLN1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/PCOLCE2/GPC3/GAPDH/CTSH/PSMD14/PRDX5/PSME2/VCP/CST3/A2M/APLP2/PYCARD/PRDX3/USP14/BAD/PSME1/BST2/CST6/TFPI2	31
GO:0070003	threonine-type peptidase activity	8/1188	24/18367	8.64490894852802e-05	0.00261443003958514	PSMB9/PSMB8/PSMB2/PSMB1/PSMB6/PSMB5/PSMB7/PSMB4	8
GO:0001618	virus receptor activity	15/1188	76/18367	8.99617214966436e-05	0.00264064111922501	EGFR/DPP4/DAG1/CXCR4/SLC52A1/TFRC/RPSA/ITGB5/ITGB1/BSG/CD55/CD86/PLSCR1/CD46/ANPEP	15
GO:0140272	exogenous protein binding	15/1188	77/18367	0.000105138183699757	0.00299794020949594	EGFR/DPP4/DAG1/CXCR4/SLC52A1/TFRC/RPSA/ITGB5/ITGB1/BSG/CD55/CD86/PLSCR1/CD46/ANPEP	15
GO:0140375	immune receptor activity	22/1188	144/18367	0.000142758729877292	0.00395758923382049	CXCR4/CD44/FCER1G/PRLR/HLA-DPA1/IFNGR2/HLA-DRA/CTSH/HLA-DRB1/IL6ST/CD74/LILRB2/FPR1/FPR3/CSF3R/HLA-DQA1/LILRB1/LILRB3/HLA-DQA2/IL10RB/LILRA2/CSF2RA	22
GO:0042287	MHC protein binding	10/1188	40/18367	0.000175153167542594	0.00472440165425701	HLA-E/TUBB4B/TUBB/PILRA/VCP/CD74/LILRB2/TAP1/LILRB1/TAPBP	10
GO:0050840	extracellular matrix binding	12/1188	56/18367	0.000198722107859561	0.00520992641611152	BCAM/ADGRG1/ITGA6/DAG1/TINAGL1/SMOC1/CTSS/RPSA/GPC1/ITGB1/VEGFA/LGALS3	12
GO:0004300	enoyl-CoA hydratase activity	5/1188	10/18367	0.000214995959482134	0.00520992641611152	ECHDC2/ECHS1/ECI1/HADHB/ECHDC1	5
GO:0032395	MHC class II receptor activity	5/1188	10/18367	0.000214995959482134	0.00520992641611152	HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQA1/HLA-DQA2	5
GO:0050786	RAGE receptor binding	5/1188	10/18367	0.000214995959482134	0.00520992641611152	S100A4/S100A8/S100A13/FPR1/S100A12	5
GO:0048027	mRNA 5'-UTR binding	8/1188	27/18367	0.000219255420317318	0.00520992641611152	MYH10/IGF2BP3/DHX36/GNL3/RPS14/RPL5/RPS7/NCL	8
GO:0003725	double-stranded RNA binding	14/1188	74/18367	0.00024437913206922	0.0056718691582577	HSPD1/TFRC/HSP90AB1/TUBB4B/VIM/DHX36/TUBA1B/CLTC/DDX1/MSN/OAS1/DHX15/OAS2/OASL	14
GO:0015036	disulfide oxidoreductase activity	10/1188	42/18367	0.00027015715686107	0.00612765551243971	P4HB/PDIA6/PDIA4/PGK1/GSTO1/GLRX5/GLRX/ERO1A/TXN2/SCO2	10
GO:0022804	active transmembrane transporter activity	45/1188	406/18367	0.000290958636241764	0.00645281597709511	SLC26A2/SLC16A12/SLC6A4/SLC38A1/SLC22A11/SLC13A4/SLC19A1/ATP6V1C2/SLC13A3/SLC9A1/SLC25A3/SLC5A3/ATP2B1/CYB5A/SLC25A5/UQCR10/SLC5A6/ATP6V1F/NDUFB7/NDUFS5/COX4I1/NDUFA6/ATP2B4/SLC11A1/NDUFC2/SLC1A3/SLCO2B1/SLC16A3/TAP1/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/SLC25A1/NDUFB1/TAPBP/NDUFA5/SLC8A1/NDUFS3/NDUFS8/ATP6V1E1/NDUFV2/NDUFA4/COX6A1	45
GO:0016504	peptidase activator activity	10/1188	43/18367	0.000331844681333166	0.0070698264990648	FBLN1/APP/PCOLCE2/CTSH/PSMD14/PSME2/VCP/PYCARD/BAD/PSME1	10
GO:0098631	cell adhesion mediator activity	12/1188	59/18367	0.000332947740937921	0.0070698264990648	BCAM/DSP/DSG2/KRT18/JAM3/DSC2/RPSA/TRIM29/PDLIM1/CNN3/ITGB1/BSG	12
GO:0097718	disordered domain specific binding	9/1188	36/18367	0.000368232515595519	0.00765616772009016	GJA5/GJA1/HSP90AB1/GAPDH/HSP90AA1/CLTC/AP2A2/MDM2/NCOA3	9
GO:0015035	protein-disulfide reductase activity	9/1188	37/18367	0.000458962995610901	0.00934785856366692	P4HB/PDIA6/PDIA4/PGK1/GLRX5/GLRX/ERO1A/TXN2/SCO2	9
GO:1901681	sulfur compound binding	32/1188	265/18367	0.000491067075817917	0.00980169883332562	FBN1/ADGRG1/CCDC80/TGFBR3/ADAMTS1/BMP7/SOD3/SMOC1/APP/NRP2/PCOLCE2/PTGES/FSTL1/ACBD6/NRP1/DBI/APOE/PTN/LRPAP1/VEGFA/PTPRC/GSTP1/ECI2/APLP2/DLD/PPIA/CXCL10/ACBD3/PRMT1/GAL3ST4/LRP1/ACADVL	32
GO:0030228	lipoprotein particle receptor activity	6/1188	18/18367	0.000683015841736989	0.0133656825500689	LRP2/OLR1/CXCL16/LRP1/SORL1/APOBR	6
GO:0030515	snoRNA binding	8/1188	32/18367	0.000777966568516115	0.0149309737572901	NUDT4/PRKDC/SNU13/ISG20/NHP2/NOP56/NUDT5/IMP3	8
GO:0019199	transmembrane receptor protein kinase activity	20/1188	143/18367	0.000898084218186884	0.0169110952783115	EGFR/MET/CRIM1/EFEMP1/TGFBR3/EPHB4/LTBP1/NRP2/ERBB3/WEE1/FLT1/IGF1R/NRP1/YES1/HCK/JAK1/FGR/SYK/JAK2/LYN	20
GO:0005539	glycosaminoglycan binding	28/1188	230/18367	0.000945025650263133	0.0174654740548631	FBN1/ADGRG1/CCDC80/TGFBR3/ADAMTS1/BMP7/SOD3/SMOC1/EXTL2/APP/NRP2/CD44/PCOLCE2/FSTL1/VCAN/NRP1/APOE/PTN/LRPAP1/VEGFA/PTPRC/C1QBP/APLP2/TREM2/PPIA/TLR2/CXCL10/SULF2	28
GO:0003714	transcription corepressor activity	24/1188	187/18367	0.00102052197494888	0.0183291340926801	TFAP2A/PAWR/CBX4/YAP1/TBL1X/SIAH2/C1QBP/DNMT3A/PFDN5/EID2/CCND1/BRD7/PA2G4/BASP1/HSBP1L1/CDYL/TRIM22/PHB/TLE4/SF1/GMNN/SRSF2/APEX1/PARP9	24
GO:0004714	transmembrane receptor protein tyrosine kinase activity	18/1188	124/18367	0.00102848848616241	0.0183291340926801	EGFR/MET/CRIM1/EFEMP1/EPHB4/NRP2/ERBB3/WEE1/FLT1/IGF1R/NRP1/YES1/HCK/JAK1/FGR/SYK/JAK2/LYN	18
GO:0016860	intramolecular oxidoreductase activity	10/1188	51/18367	0.00138112174938537	0.0241817457173088	PTGES/RPIA/P4HB/TPI1/PDIA6/PDIA4/ECI1/ECI2/ECH1/ERO1A	10
GO:0003712	transcription coregulator activity	49/1188	489/18367	0.0015423329338094	0.0265387632403756	MAGED1/PAGE4/PTPN14/TFAP2A/VGLL1/PAWR/ARID5B/CBX4/PDLIM1/YAP1/PIR/RBPMS/BRD4/NPM1/TBL1X/SMARCA2/SIAH2/C1QBP/ARID3A/DNMT3A/TAF11/USP22/PFDN5/EID2/DDX1/CCND1/RUVBL1/FUS/MED19/BRD7/PA2G4/NUCKS1/BASP1/HSBP1L1/NCOA3/PARK7/CDYL/TRIM22/PHB/TLE4/PMF1/SND1/SF1/GMNN/BCLAF1/SRSF2/APEX1/PARP9/LMO2	49
GO:0016835	carbon-oxygen lyase activity	13/1188	79/18367	0.00157699904125815	0.0266753397148412	HACD3/CA8/ECHDC2/ECHS1/TPI1/ECI1/PARK7/ENO1/CDYL/HADHB/ACO2/RPS3/ECHDC1	13
GO:0061135	endopeptidase regulator activity	24/1188	194/18367	0.00169733143094378	0.0282322794680315	ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/GAPDH/PSMD14/PRDX5/PSME2/CST3/A2M/APLP2/PRDX3/USP14/PSME1/BST2/CST6/TFPI2	24
GO:0051015	actin filament binding	26/1188	217/18367	0.00177250347689949	0.0289993191794376	EGFR/MYH10/SYNE2/SLC6A4/FERMT1/CTNNAL1/FERMT2/SCIN/DSTN/LIMA1/AIF1/COTL1/MYO7A/LCP1/ARPC3/FLNA/ARPC5L/MARCKSL1/TRIOBP/MYO1G/ADD3/ABI3/FMNL1/UTRN/IQGAP2/MYO1F	26
GO:0019838	growth factor binding	19/1188	141/18367	0.00185849834250742	0.0299158281584258	LRP2/EGFR/CRIM1/ITGB4/TGFBR3/ITGA6/LTBP1/NRP2/GPC1/ERBB3/FLT1/IGF1R/NRP1/DUSP1/PTN/S100A13/HTRA1/A2M/IL6ST	19
GO:0016829	lyase activity	24/1188	196/18367	0.00195013567027216	0.0304168510443246	GLDC/MGST3/HACD3/CA8/ALDOA/GGCT/ECHDC2/RNASET2/ECHS1/PISD/TPI1/PAICS/APMAP/ECI1/PARK7/ENO1/CDYL/RSAD2/HADHB/ACO2/UROD/RPS3/ECHDC1/NPL	24
GO:0005041	low-density lipoprotein particle receptor activity	5/1188	15/18367	0.00195057962608895	0.0304168510443246	LRP2/OLR1/CXCL16/LRP1/SORL1	5
GO:0030276	clathrin binding	12/1188	72/18367	0.00210608208087411	0.0323364602571132	NSG1/SYT7/AP1S1/AP1B1/DAB2/AP1M2/CLTA/CLTC/PIK3C2A/AP2A2/AP1S2/LRP1	12
GO:0016836	hydro-lyase activity	11/1188	64/18367	0.00247629732667548	0.0374446171518505	HACD3/CA8/ECHDC2/ECHS1/ECI1/PARK7/ENO1/CDYL/HADHB/ACO2/ECHDC1	11
GO:0005525	GTP binding	39/1188	377/18367	0.00255373849716422	0.0380392689577596	RHOBTB3/HSP90AB1/GBP2/TUBB4B/GNAI1/TUBB/GNAS/RND3/GBP1/GNA11/RHOA/TGM2/RAB25/GBP4/MX1/IFI44L/MX2/TUBA1B/SRPRB/RHOBTB1/RAN/GNL3/AK3/GBP5/ARL4A/EIF5/HRAS/ARF4/TUBA1C/RRAS/ARL1/GNAI2/EIF5B/RHOG/NME1/RAB2A/GCH1/RAB11A/GIMAP4	39
GO:0008022	protein C-terminus binding	23/1188	189/18367	0.00259236919220205	0.0380468302032006	BCAM/FBLN1/HIC2/YAP1/NCF2/SIAH1/TBL1X/ID1/DLG1/DAB2/CIB1/PRRC2C/MKI67/PRDX3/DST/CENPF/PABPC1/HRAS/PHB/NCL/CD2AP/TOP2A/JAK2	23
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/1188	10/18367	0.00266732921940332	0.0385796313183262	CYBA/CYBB/NCF2/NCF1	4
GO:0045309	protein phosphorylated amino acid binding	10/1188	56/18367	0.00287160594791071	0.0409408962287841	RASA1/YES1/GRB2/PTPN6/HCK/RTF1/FGR/YWHAE/SOCS3/SYK	10
GO:0004713	protein tyrosine kinase activity	18/1188	136/18367	0.00294715823969576	0.0414262524396672	EGFR/MET/CRIM1/EFEMP1/EPHB4/NRP2/ERBB3/WEE1/FLT1/IGF1R/NRP1/YES1/HCK/JAK1/FGR/SYK/JAK2/LYN	18
GO:0043021	ribonucleoprotein complex binding	19/1188	149/18367	0.0034991743519422	0.0482961421981212	RPSA/RPN2/NPM1/HSPA5/C1QBP/SNRPG/EIF1/SERBP1/MDM2/CBX5/SNRPD1/CCDC47/NAA10/SNRPB2/SND1/SNRPD2/NME1/RBM3/SNRPC	19
GO:0032393	MHC class I receptor activity	5/1188	17/18367	0.00360651588356705	0.0482961421981212	CTSH/LILRB2/LILRB1/LILRB3/LILRA2	5
GO:0070628	proteasome binding	5/1188	17/18367	0.00360651588356705	0.0482961421981212	PSMD14/ID1/PSMG1/USP14/RAD23B	5
GO:0038024	cargo receptor activity	12/1188	77/18367	0.00374573092949491	0.0482961421981212	LRP2/COLEC12/FOLR1/TFRC/OLR1/DAB2/CXCL16/ASGR1/LRP1/SORL1/LGALS3BP/APOBR	12
GO:0098632	cell-cell adhesion mediator activity	9/1188	49/18367	0.00377221892378495	0.0482961421981212	DSP/DSG2/KRT18/JAM3/DSC2/TRIM29/PDLIM1/CNN3/BSG	9
GO:0019001	guanyl nucleotide binding	40/1188	398/18367	0.00377464838822991	0.0482961421981212	SLC19A1/RHOBTB3/HSP90AB1/GBP2/TUBB4B/GNAI1/TUBB/GNAS/RND3/GBP1/GNA11/RHOA/TGM2/RAB25/GBP4/MX1/IFI44L/MX2/TUBA1B/SRPRB/RHOBTB1/RAN/GNL3/AK3/GBP5/ARL4A/EIF5/HRAS/ARF4/TUBA1C/RRAS/ARL1/GNAI2/EIF5B/RHOG/NME1/RAB2A/GCH1/RAB11A/GIMAP4	40
GO:0032561	guanyl ribonucleotide binding	40/1188	398/18367	0.00377464838822991	0.0482961421981212	SLC19A1/RHOBTB3/HSP90AB1/GBP2/TUBB4B/GNAI1/TUBB/GNAS/RND3/GBP1/GNA11/RHOA/TGM2/RAB25/GBP4/MX1/IFI44L/MX2/TUBA1B/SRPRB/RHOBTB1/RAN/GNL3/AK3/GBP5/ARL4A/EIF5/HRAS/ARF4/TUBA1C/RRAS/ARL1/GNAI2/EIF5B/RHOG/NME1/RAB2A/GCH1/RAB11A/GIMAP4	40
GO:0042608	T cell receptor binding	4/1188	11/18367	0.00397827853644475	0.0496290247421483	HLA-A/HLA-E/HLA-DRA/HLA-DRB1	4
GO:0043560	insulin receptor substrate binding	4/1188	11/18367	0.00397827853644475	0.0496290247421483	PRKCZ/IGF1R/GRB2/JAK2	4
GO:0019902	phosphatase binding	23/1188	196/18367	0.00410268710329495	0.050549157149239	EGFR/MET/SOD1/HSP90B1/KCNN4/SH2D4A/SLC9A1/SH3YL1/STAT1/DLG1/VCP/LGALS3/GRB2/ATP2B4/CARHSP1/LILRB2/LILRB4/JAK1/BAD/LILRB1/SNX3/SYK/ENSA	23
GO:0048306	calcium-dependent protein binding	13/1188	88/18367	0.00419531176030298	0.0510600138631997	S100P/S100A4/ANXA3/S100A6/S100A10/SLC9A1/S100A8/S100A13/A2M/ATP2B4/S100A12/CLN3/PDCD6	13
GO:0030414	peptidase inhibitor activity	22/1188	187/18367	0.00477949757513213	0.0574691395178538	ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/GPC3/GAPDH/PRDX5/CST3/A2M/APLP2/PRDX3/USP14/BST2/CST6/TFPI2	22
GO:0008201	heparin binding	20/1188	166/18367	0.00532652773629992	0.0629367952517878	FBN1/ADGRG1/CCDC80/TGFBR3/ADAMTS1/BMP7/SOD3/SMOC1/APP/NRP2/PCOLCE2/FSTL1/NRP1/APOE/PTN/LRPAP1/VEGFA/PTPRC/APLP2/CXCL10	20
GO:0140297	DNA-binding transcription factor binding	39/1188	394/18367	0.00541259028416053	0.0629367952517878	TACC2/ISL1/PARP1/TBX3/YAP1/KLF5/NFKBIA/NPM1/FBP1/STAT1/CEBPB/FOXO4/FOS/HMGN3/TAF11/SPI1/KLF4/FUS/TRIP6/BHLHE41/NCOA3/PARK7/CBX5/CENPF/CREM/PTMA/HDAC2/CALR/TLE4/OASL/GMNN/ACTB/APEX1/JUN/RPS3/PARP9/GABARAPL1/LMO2/NR4A1	39
GO:0044325	transmembrane transporter binding	17/1188	133/18367	0.00542341121408192	0.0629367952517878	TCAF1/ANK3/HSP90AB1/S100A10/SLC5A3/YES1/DLG1/BAG2/FLNA/AKAP9/CIB1/PYCARD/YWHAE/TSPO/SLC8A1/VDAC1/LYN	17
GO:0032396	inhibitory MHC class I receptor activity	4/1188	12/18367	0.00566456529822965	0.0649797260647493	LILRB2/LILRB1/LILRB3/LILRA2	4
GO:0035615	clathrin adaptor activity	5/1188	19/18367	0.00608341923110186	0.0689915044618143	AP1S1/DAB2/AP1M2/AP2A2/AP1S2	5
GO:0004866	endopeptidase inhibitor activity	21/1188	180/18367	0.00632364158490345	0.0701524924599188	ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/GAPDH/PRDX5/CST3/A2M/APLP2/PRDX3/USP14/BST2/CST6/TFPI2	21
GO:0042887	amide transmembrane transporter activity	7/1188	35/18367	0.00632637707554378	0.0701524924599188	GJA1/SLC19A1/SLC13A3/SLC5A6/TAP1/TAPBP/AQP9	7
GO:0005200	structural constituent of cytoskeleton	14/1188	103/18367	0.00646904877191128	0.0709462711468951	DSP/ANK3/TUBB4B/TUBB/HLA-DRB1/ARPC3/VIM/TUBA1B/MSN/KRT19/TUBA1C/ADD3/ACTB/CD2AP	14
GO:0001784	phosphotyrosine residue binding	8/1188	44/18367	0.00658679386937575	0.0711526788046121	RASA1/YES1/GRB2/PTPN6/HCK/FGR/SOCS3/SYK	8
GO:0016853	isomerase activity	19/1188	158/18367	0.00663046004892678	0.0711526788046121	ISYNA1/HSPD1/PTGES/PPIC/RPIA/P4HB/DEGS1/TPI1/PDIA6/PPIB/PDIA4/ECI1/ECI2/ECH1/FKBP3/ERO1A/PPIA/TOP2A/FKBP2	19
GO:0003924	GTPase activity	34/1188	337/18367	0.0067801898023557	0.071985419390968	RHOBTB3/RASA1/GBP2/TUBB4B/GNAI1/TUBB/GNAS/RND3/GBP1/GNA11/RHOA/RAB25/GBP4/MX1/MX2/TUBA1B/RHOBTB1/RAN/GBP5/ARL4A/ARHGDIB/HRAS/ARF4/TUBA1C/RRAS/ARL1/RGS10/GNAI2/EIF5B/RHOG/RAB2A/GCH1/RAB11A/RGS19	34
GO:0004715	non-membrane spanning protein tyrosine kinase activity	8/1188	45/18367	0.00756738147478971	0.0763402052917355	WEE1/YES1/HCK/JAK1/FGR/SYK/JAK2/LYN	8
GO:0001540	amyloid-beta binding	12/1188	84/18367	0.00761775671880189	0.0763402052917355	ITM2C/APOE/C1QA/LRPAP1/CST3/PFDN5/CD74/TREM2/LILRB2/TLR2/LRP1/SORL1	12
GO:0140312	cargo adaptor activity	5/1188	20/18367	0.00768610489278681	0.0763402052917355	AP1S1/DAB2/AP1M2/AP2A2/AP1S2	5
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4/1188	13/18367	0.00776791443009988	0.0763402052917355	PGK1/DLD/PRDX3/GLRX	4
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	4/1188	13/18367	0.00776791443009988	0.0763402052917355	DUSP9/DUSP5/DUSP14/DUSP1	4
GO:0031386	protein tag	4/1188	13/18367	0.00776791443009988	0.0763402052917355	ISG15/UBB/RPS27A/NEDD8	4
GO:0031994	insulin-like growth factor I binding	4/1188	13/18367	0.00776791443009988	0.0763402052917355	LRP2/ITGB4/ITGA6/IGF1R	4
GO:0042826	histone deacetylase binding	16/1188	127/18367	0.00785913012292315	0.0763402052917355	BEX4/PARP1/GLI3/HSP90AB1/HSP90AA1/CEBPB/DHX36/SPI1/CCND1/KLF4/BHLHE41/HDAC2/PHB/YWHAE/GMNN/TOP2A	16
GO:0001968	fibronectin binding	6/1188	28/18367	0.00795529193420891	0.0763402052917355	CCDC80/FBLN1/CTSL/CTSS/ITGB1/VEGFA	6
GO:0051861	glycolipid binding	6/1188	28/18367	0.00795529193420891	0.0763402052917355	GPAA1/CLEC4E/TREM2/CLN3/MANF/LYN	6
GO:0019903	protein phosphatase binding	18/1188	150/18367	0.00826103145928476	0.0785191371082495	EGFR/MET/SOD1/HSP90B1/KCNN4/SLC9A1/STAT1/VCP/LGALS3/GRB2/ATP2B4/LILRB2/LILRB4/JAK1/BAD/LILRB1/SNX3/ENSA	18
GO:0019955	cytokine binding	17/1188	139/18367	0.00839303093089215	0.0790211780097204	TGFBR3/LTBP1/CXCR4/NRP2/PRLR/NRP1/ITGB1/ZFP36/GBP1/A2M/IL6ST/CD74/PARK7/PLP2/CSF3R/TNFRSF1B/CSF2RA	17
GO:0008514	organic anion transmembrane transporter activity	21/1188	185/18367	0.00858045757461064	0.0799970259997444	SLC26A2/SLC2A1/SLC16A12/SLC38A1/GJA1/SLC22A11/SLC38A9/SLC19A1/SLC52A1/SLC35B4/SLC13A3/MPC2/SLC25A5/SLC5A6/SLC1A3/SLC29A1/SLC2A3/SLCO2B1/SLC16A3/SLC25A13/SLC25A1	21
GO:0046915	transition metal ion transmembrane transporter activity	7/1188	37/18367	0.00865699279355952	0.0799970259997444	SLC40A1/SLC39A10/SLC25A37/SLC39A1/SLC11A1/SLC39A7/TMEM165	7
GO:0051087	chaperone binding	14/1188	107/18367	0.0090113220153862	0.0825073336821599	LRP2/HLA-B/HSPD1/SOD1/HSPE1/ST13/HSPA5/BAG2/DNAJB4/TBCA/CALR/HSPA8/ERP29/GRN	14
GO:0005520	insulin-like growth factor binding	6/1188	29/18367	0.00949316570395003	0.0861289033867466	LRP2/CRIM1/ITGB4/ITGA6/IGF1R/HTRA1	6
GO:0051219	phosphoprotein binding	12/1188	88/18367	0.010942312568981	0.098382233728316	RASA1/CBX4/YES1/GRB2/PTPN6/HCK/RTF1/FGR/YWHAE/SOCS3/SYK/LYN	12
GO:0046966	thyroid hormone receptor binding	6/1188	30/18367	0.0112316529740465	0.100082050608021	HMGN3/TAF11/FUS/TRIP6/NCOA3/OASL	6
GO:0000062	fatty-acyl-CoA binding	5/1188	22/18367	0.0117261651262462	0.102655375403453	ACBD6/DBI/ECI2/ACBD3/ACADVL	5
GO:0072349	modified amino acid transmembrane transporter activity	5/1188	22/18367	0.0117261651262462	0.102655375403453	SLC16A12/GJA1/SLC19A1/SLC13A3/SLC5A6	5
GO:0003697	single-stranded DNA binding	15/1188	123/18367	0.0131032718037558	0.109382767336518	SMARCA1/HSPD1/MCM3/MCM6/MCM7/DHX36/LRPPRC/RAD50/NUCKS1/RPA3/RAD23B/RTF1/YBX1/SSBP1/NME1	15
GO:0090482	vitamin transmembrane transporter activity	6/1188	31/18367	0.0131833625744285	0.109382767336518	SLC2A1/SLC19A3/SLC19A1/SLC52A1/SLC5A6/SLC2A3	6
GO:0004177	aminopeptidase activity	7/1188	40/18367	0.0132534550613736	0.109382767336518	DPP4/CTSV/ENPEP/CTSH/LAP3/METAP2/ANPEP	7
GO:0044183	protein folding chaperone	7/1188	40/18367	0.0132534550613736	0.109382767336518	HSP90AB1/HSPA5/CCT2/CD74/CCDC47/CALR/HSPA8	7
GO:0032794	GTPase activating protein binding	4/1188	15/18367	0.0133714404960473	0.109382767336518	CDH1/GNAI1/TUBB/FMNL1	4
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	4/1188	15/18367	0.0133714404960473	0.109382767336518	CYBA/CYBB/NCF2/NCF1	4
GO:0050998	nitric-oxide synthase binding	4/1188	15/18367	0.0133714404960473	0.109382767336518	SLC6A4/ATP2B4/CD74/ACTB	4
GO:1904680	peptide transmembrane transporter activity	4/1188	15/18367	0.0133714404960473	0.109382767336518	GJA1/SLC13A3/TAP1/TAPBP	4
GO:0019865	immunoglobulin binding	5/1188	23/18367	0.0142026424371581	0.11430836413132	FCGR3A/FCER1G/LGALS3/FCGR2A/LILRA2	5
GO:1901567	fatty acid derivative binding	5/1188	23/18367	0.0142026424371581	0.11430836413132	ACBD6/DBI/ECI2/ACBD3/ACADVL	5
GO:0005507	copper ion binding	9/1188	61/18367	0.0159657140049043	0.127470260615156	F5/SOD3/SOD1/GPC1/S100A13/CUTA/PARK7/S100A12/SCO2	9
GO:0051537	2 iron, 2 sulfur cluster binding	5/1188	24/18367	0.0170071533744754	0.133693952021824	CISD1/GLRX5/FDX1/ISCU/NDUFV2	5
GO:0030246	carbohydrate binding	27/1188	271/18367	0.0170131582232181	0.133693952021824	COLEC12/ALDOA/AGL/LMAN1/VCAN/GALNT11/FCN1/RPIA/OLR1/HLA-DRA/FBP1/BSG/HLA-DRB1/CLEC4E/MLEC/LGALS3/GANAB/GPCPD1/LGALS2/SLC2A3/CHID1/CALR/CD69/CLEC12A/ASGR1/P4HA1/UGP2	27
GO:0005154	epidermal growth factor receptor binding	6/1188	33/18367	0.0177742392423958	0.138583521593054	EFEMP1/YES1/VAV3/GRB2/PLSCR1/ARF4	6
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	29/1188	299/18367	0.0191942968232694	0.148495412632735	TACC2/ISL1/PARP1/TBX3/NFKBIA/NPM1/FBP1/STAT1/CEBPB/FOS/HMGN3/TAF11/SPI1/KLF4/FUS/TRIP6/BHLHE41/NCOA3/PARK7/HDAC2/CALR/OASL/ACTB/APEX1/JUN/PARP9/GABARAPL1/LMO2/NR4A1	29
GO:0120227	acyl-CoA binding	5/1188	25/18367	0.0201555200114072	0.154732376702956	ACBD6/DBI/ECI2/ACBD3/ACADVL	5
GO:0017124	SH3 domain binding	15/1188	130/18367	0.0208391489522486	0.158759317972092	LRP2/GJA1/CYBA/NCF1/GPX1/FUT8/GRB2/PLSCR1/WASF2/PTPN6/VASP/ABI3/CD2AP/WIPF1/LYN	15
GO:0015459	potassium channel regulator activity	8/1188	54/18367	0.0219390625621643	0.165872609371515	PRKCZ/RASA1/SLC5A3/DLG1/FLNA/AKAP9/YWHAE/ENSA	8
GO:0008330	protein tyrosine/threonine phosphatase activity	3/1188	10/18367	0.0229754276269387	0.168599093909447	DUSP9/DUSP5/DUSP1	3
GO:0030957	Tat protein binding	3/1188	10/18367	0.0229754276269387	0.168599093909447	NPM1/ACTB/GABARAPL1	3
GO:0034511	U3 snoRNA binding	3/1188	10/18367	0.0229754276269387	0.168599093909447	PRKDC/SNU13/ISG20	3
GO:0034713	type I transforming growth factor beta receptor binding	3/1188	10/18367	0.0229754276269387	0.168599093909447	FERMT2/TGFB1/SNX6	3
GO:0038187	pattern recognition receptor activity	5/1188	26/18367	0.0236618380067387	0.17236871774252	COLEC12/FCN1/CD14/CLEC4E/TLR2	5
GO:0004867	serine-type endopeptidase inhibitor activity	12/1188	98/18367	0.0241010155731158	0.174295750304127	ITIH5/CRIM1/SPINT1/SERPINH1/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/A2M/APLP2/TFPI2	12
GO:0022853	active ion transmembrane transporter activity	26/1188	267/18367	0.0244452389295324	0.175513298213477	SLC26A2/SLC6A4/SLC38A1/SLC22A11/SLC13A4/SLC19A1/ATP6V1C2/SLC13A3/SLC9A1/SLC25A3/SLC5A3/ATP2B1/CYB5A/SLC25A5/UQCR10/SLC5A6/ATP6V1F/COX4I1/ATP2B4/SLC11A1/SLC1A3/SLCO2B1/SLC25A1/SLC8A1/ATP6V1E1/COX6A1	26
GO:0033549	MAP kinase phosphatase activity	4/1188	18/18367	0.025690956029152	0.181840951185062	DUSP9/DUSP5/DUSP14/DUSP1	4
GO:0098641	cadherin binding involved in cell-cell adhesion	4/1188	18/18367	0.025690956029152	0.181840951185062	KRT18/TRIM29/PDLIM1/CNN3	4
GO:0043394	proteoglycan binding	6/1188	36/18367	0.0265410056387655	0.186534673433014	CTSL/CTSS/APOE/PTN/PTPRC/LRP1	6
GO:0051287	NAD binding	8/1188	56/18367	0.026763828770575	0.186785322468768	LDHA/PARP1/GAPDH/IDH1/ALDH2/HPGD/DLD/MDH1	8
GO:0008094	ATP-dependent activity, acting on DNA	13/1188	111/18367	0.0269850992381351	0.187021729442075	SMARCA1/MCM3/HELLS/MCM6/SMARCA2/MCM7/DHX36/DDX1/RUVBL1/RAD50/RFC1/TOP2A/SMC3	13
GO:0003823	antigen binding	18/1188	171/18367	0.028312461965643	0.194867841666977	HLA-B/HLA-A/HLA-C/HLA-E/FCN1/DHCR24/HLA-DPA1/HLA-DRA/HLA-F/HLA-DRB1/HLA-DPB1/CD48/TGFB1/TAP1/HLA-DQA1/TSPAN4/TAPBP/LILRA2	18
GO:0005201	extracellular matrix structural constituent	18/1188	172/18367	0.0297863499964874	0.198598490190318	FBN1/COL14A1/FBN2/LAMA5/VWA1/COL4A2/LAMB1/FBLN1/EFEMP1/TINAGL1/FRAS1/LAMC1/COL21A1/LTBP1/VCAN/FGL2/MFAP5/TFPI2	18
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	6/1188	37/18367	0.0300024274797731	0.198598490190318	ALDH7A1/GAPDH/ADH5/AKR1B1/ALDH2/DLD	6
GO:0043531	ADP binding	6/1188	37/18367	0.0300024274797731	0.198598490190318	MYH10/MYO7A/VCP/RUVBL1/PGK1/TAP1	6
GO:0019864	IgG binding	3/1188	11/18367	0.030099358535874	0.198598490190318	FCGR3A/FCER1G/FCGR2A	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/1188	11/18367	0.030099358535874	0.198598490190318	DSP/DSG2/DSC2	3
GO:0097493	structural molecule activity conferring elasticity	3/1188	11/18367	0.030099358535874	0.198598490190318	FBN1/FBN2/LAMC1	3
GO:0051536	iron-sulfur cluster binding	9/1188	68/18367	0.0304464619229646	0.198598490190318	CISD1/GLRX5/FDX1/RSAD2/ACO2/ISCU/NDUFS8/RPS3/NDUFV2	9
GO:0051540	metal cluster binding	9/1188	68/18367	0.0304464619229646	0.198598490190318	CISD1/GLRX5/FDX1/RSAD2/ACO2/ISCU/NDUFS8/RPS3/NDUFV2	9
GO:0070325	lipoprotein particle receptor binding	5/1188	28/18367	0.0317955853097646	0.206051909994449	HSP90B1/APOE/LRPAP1/CLTC/LRP1	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	8/1188	58/18367	0.0322793368638982	0.207837278646261	PTGES/SMS/FDFT1/GSTA4/SRM/FDPS/GSTP1/GSTO1	8
GO:0005518	collagen binding	9/1188	69/18367	0.0330821654458869	0.21164103278843	COL14A1/ADGRG1/CTSL/SERPINH1/CTSS/CD44/PCOLCE2/ITGB1/PPIB	9
GO:0015026	coreceptor activity	7/1188	48/18367	0.0335630785149792	0.213350015018785	TGFBR3/LRP5/CXCR4/NRP1/ITGB1/CD86/LRP1	7
GO:0008509	anion transmembrane transporter activity	29/1188	314/18367	0.0339495677482801	0.214440940587238	SLC26A2/CLDN4/SLC2A1/SLC16A12/SLC6A4/SLC38A1/GJA1/SLC22A11/SLC13A4/FXYD3/CLIC3/GABRE/SLC38A9/SLC19A1/SLC52A1/SLC35B4/SLC13A3/SLC9A1/MPC2/SLC25A5/SLC5A6/SLC1A3/SLC29A1/SLC2A3/SLCO2B1/SLC16A3/SLC25A13/SLC25A1/VDAC1	29
GO:0004857	enzyme inhibitor activity	9/1188	70/18367	0.0358714356106944	0.224874591311461	ANXA3/RPL23/OAZ1/APOC1/RPL5/RPL37/TXNIP/RPS7/PARP9	9
GO:0005516	calmodulin binding	20/1188	201/18367	0.0365470875698796	0.224874591311461	EGFR/MYH10/CALD1/SYT7/ASPM/TJP1/KCNN4/SLC9A1/CNN3/MYO7A/ATP2B1/CAMK2G/ATP2B4/MARCKSL1/MYO1G/PHKB/ADD3/SLC8A1/IQGAP2/MYO1F	20
GO:0003756	protein disulfide isomerase activity	4/1188	20/18367	0.0367280144125933	0.224874591311461	P4HB/PDIA6/PDIA4/ERO1A	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4/1188	20/18367	0.0367280144125933	0.224874591311461	P4HB/PDIA6/PDIA4/ERO1A	4
GO:0031683	G-protein beta/gamma-subunit complex binding	4/1188	20/18367	0.0367280144125933	0.224874591311461	GNAI1/GNAS/GNA11/GNAI2	4
GO:0060090	molecular adaptor activity	33/1188	369/18367	0.0370984504083988	0.225757643338915	COL14A1/SYNE2/DLG5/SORBS1/ANK3/FRMD4A/OBSL1/DDB1/MPP7/SLC9A1/ST13/AP1S1/DLG1/DAB2/AP1M2/EPS8/GRB2/PSMC6/PDE4DIP/KLF4/AKAP9/CIB1/PSMG1/RAD50/AP2A2/CBX5/CDYL/TRIM22/AP1S2/LAMTOR5/ISCU/HSPA8/PDCD6	33
GO:0008429	phosphatidylethanolamine binding	3/1188	12/18367	0.0382442896150888	0.228549706801549	PEBP1/TREM2/CD300A	3
GO:0017154	semaphorin receptor activity	3/1188	12/18367	0.0382442896150888	0.228549706801549	MET/NRP2/NRP1	3
GO:0035325	Toll-like receptor binding	3/1188	12/18367	0.0382442896150888	0.228549706801549	S100A8/TLR2/SYK	3
GO:0048029	monosaccharide binding	9/1188	71/18367	0.0388176888019298	0.230595556097178	COLEC12/ALDOA/LMAN1/RPIA/FBP1/BSG/SLC2A3/P4HA1/UGP2	9
GO:0070851	growth factor receptor binding	15/1188	141/18367	0.0393566670745193	0.232413927457812	EFEMP1/APP/GATA3/YES1/VEGFA/VAV3/GRB2/PLSCR1/IL6ST/PYCARD/TRIP6/ARF4/CD2AP/JAK2/LYN	15
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	7/1188	50/18367	0.0407766737160949	0.239383060992134	CDKN1C/CCND3/CCNE1/CCND1/CKS2/CKS1B/CCNB1	7
GO:0001848	complement binding	4/1188	21/18367	0.0431204208401669	0.251661871336179	CD59/C1QBP/CALR/PHB	4
GO:0030674	protein-macromolecule adaptor activity	27/1188	296/18367	0.0450635209848449	0.261473220598111	COL14A1/SYNE2/DLG5/SORBS1/ANK3/FRMD4A/OBSL1/DDB1/MPP7/SLC9A1/ST13/AP1S1/DAB2/AP1M2/EPS8/GRB2/PSMC6/KLF4/CIB1/RAD50/AP2A2/CBX5/CDYL/TRIM22/AP1S2/HSPA8/PDCD6	27
GO:0016859	cis-trans isomerase activity	6/1188	41/18367	0.0467357979715111	0.26420350707399	PPIC/DEGS1/PPIB/FKBP3/PPIA/FKBP2	6
GO:0071813	lipoprotein particle binding	5/1188	31/18367	0.0469264024675799	0.26420350707399	COLEC12/HSPD1/APOE/TREM2/SORL1	5
GO:0071814	protein-lipid complex binding	5/1188	31/18367	0.0469264024675799	0.26420350707399	COLEC12/HSPD1/APOE/TREM2/SORL1	5
GO:0005542	folic acid binding	3/1188	13/18367	0.0473872021705854	0.26420350707399	FOLR1/SLC19A1/TYMS	3
GO:0061133	endopeptidase activator activity	3/1188	13/18367	0.0473872021705854	0.26420350707399	PSMD14/PSME2/PSME1	3
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	3/1188	13/18367	0.0473872021705854	0.26420350707399	CKS2/CKS1B/CCNB1	3
GO:0070700	BMP receptor binding	3/1188	13/18367	0.0473872021705854	0.26420350707399	BMP7/PYCARD/GDF15	3
GO:0000287	magnesium ion binding	21/1188	221/18367	0.0497588171625007	0.275884997378754	S100P/WEE1/GNAI1/COMT/IDH1/ATP10D/PRKACB/PGP/DHX36/PLSCR1/RAN/STK26/PKM/ENO1/AASDHPPT/GLUL/NUDT5/NME1/PDCD6/DUT/TOP2A	21
GO:0055106	ubiquitin-protein transferase regulator activity	4/1188	22/18367	0.050096922109927	0.276225018042581	RPL23/RPL5/RPL37/RPS7	4
GO:0071889	14-3-3 protein binding	5/1188	32/18367	0.0527719599146505	0.289375912059457	PRKCZ/ZFP36/HLA-F/BAD/ZFP36L1	5
GO:0017069	snRNA binding	7/1188	53/18367	0.0533659058848299	0.291033738104155	SNRPA1/LSM7/SNU13/LSM3/ISG20/SNRPB2/SNRPD3	7
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	3/1188	14/18367	0.0574948361450928	0.306588584764825	ECI1/ECI2/ECH1	3
GO:0071837	HMG box domain binding	3/1188	14/18367	0.0574948361450928	0.306588584764825	GATA3/DLX5/JUN	3
GO:0008143	poly(A) binding	4/1188	23/18367	0.0576536125673521	0.306588584764825	RBPMS/DDX1/HNRNPDL/PABPC1	4
GO:0050750	low-density lipoprotein particle receptor binding	4/1188	23/18367	0.0576536125673521	0.306588584764825	HSP90B1/APOE/LRPAP1/CLTC	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	13/1188	124/18367	0.0577541622603077	0.306588584764825	HSD17B1/LDHB/LDHA/ADH5/GCLM/IDH1/AKR1B1/HPGD/DCXR/MDH1/HSD17B11/HADHB/IMPDH2	13
GO:0001530	lipopolysaccharide binding	5/1188	33/18367	0.0590215528918388	0.310018472558185	HSPD1/CD14/TREM2/TLR2/PSMB4	5
GO:0019956	chemokine binding	5/1188	33/18367	0.0590215528918388	0.310018472558185	CXCR4/ITGB1/ZFP36/A2M/PLP2	5
GO:0051020	GTPase binding	26/1188	291/18367	0.0593468858075755	0.310095246261573	EXPH5/RHOBTB3/SOD1/RASA1/NCF2/HSP90AA1/FNBP1L/LCP1/GOLGA4/FLNA/CLTA/EPS8/CIB1/STOML2/RANBP1/YIPF2/ENO1/CCDC186/TRIOBP/ARHGDIB/YBX1/TNPO1/BNIP3/FMNL1/IQGAP2/SORL1	26
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	6/1188	44/18367	0.0624439733319585	0.323951757306913	ALDH7A1/GAPDH/ADH5/AKR1B1/ALDH2/DLD	6
GO:0046943	carboxylic acid transmembrane transporter activity	16/1188	163/18367	0.0628013594901224	0.323951757306913	SLC27A2/SLC26A2/SLC16A12/SLC38A1/SLC38A9/SLC19A1/SLC13A3/MPC2/SLC5A6/SLC1A3/SLCO2B1/SLC16A3/SLC25A13/SLC25A1/AQP9/SLC7A7	16
GO:0005080	protein kinase C binding	7/1188	55/18367	0.0629725860897205	0.323951757306913	DSP/PARD6B/HINT1/C1QBP/FLNA/SRSF2/TOP2A	7
GO:0005342	organic acid transmembrane transporter activity	16/1188	164/18367	0.0656163893820198	0.335821315914132	SLC27A2/SLC26A2/SLC16A12/SLC38A1/SLC38A9/SLC19A1/SLC13A3/MPC2/SLC5A6/SLC1A3/SLCO2B1/SLC16A3/SLC25A13/SLC25A1/AQP9/SLC7A7	16
GO:0048156	tau protein binding	6/1188	45/18367	0.0682934600306861	0.341649866761959	HSP90AB1/APOE/HSP90AA1/LGMN/BAG2/ACTB	6
GO:0046332	SMAD binding	9/1188	79/18367	0.0683654753557673	0.341649866761959	TGFBR3/PARP1/FERMT2/DAB2/FOS/FLNA/SKIL/EID2/JUN	9
GO:0001846	opsonin binding	3/1188	15/18367	0.0685256850573542	0.341649866761959	C1QBP/CALR/PHB	3
GO:0004029	aldehyde dehydrogenase (NAD+) activity	3/1188	15/18367	0.0685256850573542	0.341649866761959	ALDH7A1/ADH5/ALDH2	3
GO:0071933	Arp2/3 complex binding	3/1188	15/18367	0.0685256850573542	0.341649866761959	GMFG/WASF2/IQGAP2	3
GO:0008238	exopeptidase activity	11/1188	103/18367	0.0689819495430994	0.341649866761959	DPP4/CTSV/ENPEP/MME/TFRC/GGH/CTSH/LAP3/METAP2/CPM/ANPEP	11
GO:0045182	translation regulator activity	14/1188	140/18367	0.0691515762383925	0.341649866761959	IGF2BP3/EIF2AK1/EIF2AK4/EIF1/RPS14/EIF3A/EIF2S2/EIF5/PABPC1/EIF3J/TYMS/EIF5B/ABCF1/CIRBP	14
GO:0005160	transforming growth factor beta receptor binding	4/1188	25/18367	0.0744738347667884	0.364337681849288	TGFBR3/FERMT2/TGFB1/SNX6	4
GO:0030247	polysaccharide binding	4/1188	25/18367	0.0744738347667884	0.364337681849288	AGL/HLA-DRA/HLA-DRB1/GPCPD1	4
GO:0072341	modified amino acid binding	10/1188	93/18367	0.0775482287248309	0.376122488195838	MME/FOLR1/SLC19A1/SYT7/PTGES/SCIN/TREM2/TYMS/HSPA8/CD300A	10
GO:0019207	kinase regulator activity	21/1188	233/18367	0.0776365055795015	0.376122488195838	CDKN1C/PKIB/HSP90AB1/ERBB3/CD24/CCND3/NPM1/CCNE1/GSTP1/GMFG/CCND1/KLF4/CIB1/CKS2/TREM2/LILRB4/IGF2/CXCL10/CKS1B/SOCS3/CCNB1	21
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	3/1188	16/18367	0.0804317390994701	0.380430690148204	ALDH7A1/ADH5/ALDH2	3
GO:0005092	GDP-dissociation inhibitor activity	3/1188	16/18367	0.0804317390994701	0.380430690148204	RANBP1/EIF5/ARHGDIB	3
GO:0005159	insulin-like growth factor receptor binding	3/1188	16/18367	0.0804317390994701	0.380430690148204	GNAS/INSL4/IGF2	3
GO:0005523	tropomyosin binding	3/1188	16/18367	0.0804317390994701	0.380430690148204	CALD1/S100A6/PYCARD	3
GO:0008191	metalloendopeptidase inhibitor activity	3/1188	16/18367	0.0804317390994701	0.380430690148204	TIMP3/TIMP1/BST2	3
GO:0016922	nuclear receptor binding	14/1188	144/18367	0.0828948462545743	0.390231398877666	TACC2/ISL1/PARP1/STAT1/CEBPB/HMGN3/TAF11/FUS/TRIP6/NCOA3/PARK7/CALR/OASL/NR4A1	14
GO:0004364	glutathione transferase activity	4/1188	26/18367	0.083712379632252	0.392229835084449	PTGES/GSTA4/GSTP1/GSTO1	4
GO:0016879	ligase activity, forming carbon-nitrogen bonds	6/1188	48/18367	0.0876748462395676	0.407400897747229	ASS1/GCLM/RIMKLB/ASNSD1/PAICS/GLUL	6
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/1188	17/18367	0.093160002950375	0.407400897747229	PTPRC/PTPN6/PTPRA	3
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	3/1188	17/18367	0.093160002950375	0.407400897747229	CTSH/PYCARD/BAD	3
GO:0019198	transmembrane receptor protein phosphatase activity	3/1188	17/18367	0.093160002950375	0.407400897747229	PTPRC/PTPN6/PTPRA	3
GO:0030169	low-density lipoprotein particle binding	3/1188	17/18367	0.093160002950375	0.407400897747229	COLEC12/TREM2/SORL1	3
GO:0031489	myosin V binding	3/1188	17/18367	0.093160002950375	0.407400897747229	RAB25/FUS/RAB11A	3
GO:0034185	apolipoprotein binding	3/1188	17/18367	0.093160002950375	0.407400897747229	HSPD1/TREM2/LRP1	3
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3/1188	17/18367	0.093160002950375	0.407400897747229	ATP6V1C2/ATP6V1F/ATP6V1E1	3
GO:0043024	ribosomal small subunit binding	3/1188	17/18367	0.093160002950375	0.407400897747229	NPM1/EIF1/NME1	3
GO:0043395	heparan sulfate proteoglycan binding	3/1188	17/18367	0.093160002950375	0.407400897747229	APOE/PTPRC/LRP1	3
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	3/1188	17/18367	0.093160002950375	0.407400897747229	ATP6V1C2/ATP6V1F/ATP6V1E1	3
GO:0046961	proton-transporting ATPase activity, rotational mechanism	3/1188	17/18367	0.093160002950375	0.407400897747229	ATP6V1C2/ATP6V1F/ATP6V1E1	3
GO:0015215	nucleotide transmembrane transporter activity	4/1188	27/18367	0.0934817691223602	0.407400897747229	SLC19A1/SLC25A5/SLC25A36/SLC29A1	4
GO:0030507	spectrin binding	4/1188	27/18367	0.0934817691223602	0.407400897747229	ANK3/MYO7A/GBP1/PTPRC	4
GO:0043425	bHLH transcription factor binding	4/1188	27/18367	0.0934817691223602	0.407400897747229	ISL1/KLF5/BHLHE41/LMO2	4
GO:0070006	metalloaminopeptidase activity	4/1188	27/18367	0.0934817691223602	0.407400897747229	ENPEP/LAP3/METAP2/ANPEP	4
GO:0016763	pentosyltransferase activity	6/1188	49/18367	0.0947381445827258	0.411081166493741	TYMP/QPRT/PARP1/UPP1/PARP9/PNP	6
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	5/1188	38/18367	0.0962394643831555	0.415787815819867	PPIC/PPIB/FKBP3/PPIA/FKBP2	5
GO:0002020	protease binding	13/1188	135/18367	0.0975567739872421	0.419053852281299	DPP4/TIMP3/ADAMTSL4/SERPINA1/TIMP1/ITGB1/VCP/CST3/A2M/CLTC/PYCARD/PARK7/LRP1	13
GO:0008013	beta-catenin binding	9/1188	85/18367	0.0978352180175779	0.419053852281299	CDH1/KANK1/GJA1/DLG5/GLI3/TBL1X/FOXO4/KLF4/CD2AP	9
GO:0047485	protein N-terminus binding	11/1188	110/18367	0.0990202578383387	0.422317168045564	RPS21/PARP1/MYO7A/NPM1/ID1/TAF11/MDM2/VPS25/NCOA3/GLRX/MORF4L1	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	13/1188	136/18367	0.101842798878344	0.431747177625775	HSD17B1/LDHB/LDHA/ADH5/GCLM/IDH1/AKR1B1/HPGD/DCXR/MDH1/HSD17B11/HADHB/IMPDH2	13
GO:0005048	signal sequence binding	6/1188	50/18367	0.10209652697363	0.431747177625775	NFKBIA/SRP14/KDELR1/TNPO1/KDELR2/NUP214	6
GO:0003785	actin monomer binding	4/1188	28/18367	0.103762799757793	0.436942085056022	COBLL1/TMSB4X/TMSB10/LIMA1	4
GO:0017022	myosin binding	8/1188	74/18367	0.104490904551399	0.437768882374558	CALD1/CXCR4/RHOA/RAB25/FUS/PYCARD/TRIOBP/RAB11A	8
GO:0005504	fatty acid binding	5/1188	39/18367	0.104836435759037	0.437768882374558	ADH5/S100A8/GSTP1/NDUFAB1/APOC1	5
GO:0000295	adenine nucleotide transmembrane transporter activity	3/1188	18/18367	0.10665381233462	0.439836796322109	SLC19A1/SLC25A5/SLC29A1	3
GO:0005346	purine ribonucleotide transmembrane transporter activity	3/1188	18/18367	0.10665381233462	0.439836796322109	SLC19A1/SLC25A5/SLC29A1	3
GO:0008301	DNA binding, bending	3/1188	18/18367	0.10665381233462	0.439836796322109	TFAM/HMGB3/TOP2A	3
GO:0003743	translation initiation factor activity	6/1188	51/18367	0.109744909609563	0.450721892141333	EIF1/EIF3A/EIF2S2/EIF5/EIF3J/EIF5B	6
GO:0005126	cytokine receptor binding	23/1188	271/18367	0.110774581443787	0.453086197872541	TGFBR3/GATA3/FERMT2/PRLR/STAT1/VEGFA/CCL3L3/GRB2/IL6ST/TNFSF10/PYCARD/TNFSF13B/TGFB1/TRIP6/JAK1/CXCL10/CXCL16/SNX6/CCL4/DEFB1/CD2AP/SYK/JAK2	23
GO:0019887	protein kinase regulator activity	18/1188	204/18367	0.111897416471773	0.455398692440046	CDKN1C/PKIB/HSP90AB1/ERBB3/CD24/CCND3/NPM1/CCNE1/GMFG/CCND1/CIB1/CKS2/LILRB4/IGF2/CXCL10/CKS1B/SOCS3/CCNB1	18
GO:0031492	nucleosomal DNA binding	5/1188	40/18367	0.113797600402269	0.455398692440046	HMGN3/HDAC2/ACTB/MBD2/HMGN1	5
GO:0042169	SH2 domain binding	5/1188	40/18367	0.113797600402269	0.455398692440046	DAG1/PTPN6/LILRB1/SYK/JAK2	5
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	5/1188	40/18367	0.113797600402269	0.455398692440046	CTSH/PRDX5/PYCARD/PRDX3/BAD	5
GO:0033612	receptor serine/threonine kinase binding	4/1188	29/18367	0.114534140082617	0.455398692440046	BMP7/PYCARD/MDM2/GDF15	4
GO:0051059	NF-kappaB binding	4/1188	29/18367	0.114534140082617	0.455398692440046	NFKBIA/NPM1/HDAC2/APEX1	4
GO:0070717	poly-purine tract binding	4/1188	29/18367	0.114534140082617	0.455398692440046	RBPMS/DDX1/HNRNPDL/PABPC1	4
GO:0099106	ion channel regulator activity	13/1188	139/18367	0.115370453628173	0.4569036219084	FXYD3/PRKCZ/PRSS8/RASA1/TSPAN13/SLC5A3/DLG1/FXYD5/FLNA/ATP2B4/AKAP9/YWHAE/ENSA	13
GO:0016830	carbon-carbon lyase activity	6/1188	52/18367	0.117677409576671	0.462370294320936	ALDOA/PISD/PAICS/UROD/ECHDC1/NPL	6
GO:1901682	sulfur compound transmembrane transporter activity	6/1188	52/18367	0.117677409576671	0.462370294320936	SLC26A2/SLC19A3/GJA1/SLC13A4/SLC13A3/SLC5A6	6
GO:0004129	cytochrome-c oxidase activity	3/1188	19/18367	0.120853971051992	0.471141652773001	CYB5A/COX4I1/COX6A1	3
GO:0010314	phosphatidylinositol-5-phosphate binding	3/1188	19/18367	0.120853971051992	0.471141652773001	PHLDA3/PLEKHA5/SNX3	3
GO:0004725	protein tyrosine phosphatase activity	10/1188	102/18367	0.123310552927623	0.478847983742286	DUSP9/PTPN14/DUSP5/DUSP14/DUSP1/PGP/PTPRC/PTPN6/PTPRA/PTP4A1	10
GO:0140678	molecular function inhibitor activity	12/1188	128/18367	0.125048719767191	0.483715590417273	RASA1/ANXA3/RPL23/ID1/OAZ1/APOC1/RPL5/RPL37/TXNIP/RPS7/PARP9/ENSA	12
GO:0005310	dicarboxylic acid transmembrane transporter activity	4/1188	30/18367	0.125772626760194	0.484637380334649	SLC26A2/SLC19A1/SLC13A3/SLC25A13	4
GO:0003713	transcription coactivator activity	22/1188	262/18367	0.126406241107117	0.485205494711164	MAGED1/PAGE4/VGLL1/ARID5B/PDLIM1/YAP1/RBPMS/BRD4/NPM1/SMARCA2/TAF11/USP22/RUVBL1/FUS/BRD7/NUCKS1/NCOA3/PARK7/TRIM22/PMF1/APEX1/LMO2	22
GO:0043022	ribosome binding	7/1188	66/18367	0.133238171043107	0.48540619587739	RPSA/RPN2/HSPA5/C1QBP/SERBP1/CCDC47/NAA10	7
GO:0005384	manganese ion transmembrane transporter activity	2/1188	10/18367	0.133240182850652	0.48540619587739	SLC11A1/TMEM165	2
GO:0005522	profilin binding	2/1188	10/18367	0.133240182850652	0.48540619587739	VASP/WIPF1	2
GO:0005528	FK506 binding	2/1188	10/18367	0.133240182850652	0.48540619587739	FKBP3/FKBP2	2
GO:0008097	5S rRNA binding	2/1188	10/18367	0.133240182850652	0.48540619587739	RPL5/MDM2	2
GO:0008172	S-methyltransferase activity	2/1188	10/18367	0.133240182850652	0.48540619587739	DNMT3A/MTR	2
GO:0016176	superoxide-generating NADPH oxidase activator activity	2/1188	10/18367	0.133240182850652	0.48540619587739	NCF2/NCF1	2
GO:0016595	glutamate binding	2/1188	10/18367	0.133240182850652	0.48540619587739	SLC1A3/GLUL	2
GO:0051880	G-quadruplex DNA binding	2/1188	10/18367	0.133240182850652	0.48540619587739	DHX36/RAD50	2
GO:0071723	lipopeptide binding	2/1188	10/18367	0.133240182850652	0.48540619587739	CD14/TLR2	2
GO:0015078	proton transmembrane transporter activity	12/1188	130/18367	0.135599895384496	0.48540619587739	ATP6V1B1/ATP6V1C2/SLC9A1/SLC25A3/CYB5A/SLC25A5/UQCR10/ATP6V1F/COX4I1/SLC11A1/ATP6V1E1/COX6A1	12
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/1188	20/18367	0.135699728106004	0.48540619587739	STAT1/CEBPB/FOS	3
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	3/1188	20/18367	0.135699728106004	0.48540619587739	ATP6V1C2/ATP6V1F/ATP6V1E1	3
GO:0016018	cyclosporin A binding	3/1188	20/18367	0.135699728106004	0.48540619587739	PPIC/PPIB/PPIA	3
GO:0016500	protein-hormone receptor activity	3/1188	20/18367	0.135699728106004	0.48540619587739	LGR5/LGR4/IGF1R	3
GO:0016505	peptidase activator activity involved in apoptotic process	3/1188	20/18367	0.135699728106004	0.48540619587739	CTSH/PYCARD/BAD	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/1188	20/18367	0.135699728106004	0.48540619587739	CYB5A/COX4I1/COX6A1	3
GO:0030506	ankyrin binding	3/1188	20/18367	0.135699728106004	0.48540619587739	CDH1/PTPRC/SLC8A1	3
GO:0031690	adrenergic receptor binding	3/1188	20/18367	0.135699728106004	0.48540619587739	ADRB1/GNAS/C1QBP	3
GO:0000146	microfilament motor activity	4/1188	31/18367	0.137453548877619	0.48992372064237	MYH10/MYO7A/MYO1G/MYO1F	4
GO:0016247	channel regulator activity	13/1188	145/18367	0.145389407131248	0.516365225327349	FXYD3/PRKCZ/PRSS8/RASA1/TSPAN13/SLC5A3/DLG1/FXYD5/FLNA/ATP2B4/AKAP9/YWHAE/ENSA	13
GO:0015605	organophosphate ester transmembrane transporter activity	4/1188	32/18367	0.149550918729472	0.522980017784063	SLC19A1/SLC25A5/SLC25A36/SLC29A1	4
GO:0005385	zinc ion transmembrane transporter activity	3/1188	21/18367	0.15112961265031	0.522980017784063	SLC39A10/SLC39A1/SLC39A7	3
GO:0015216	purine nucleotide transmembrane transporter activity	3/1188	21/18367	0.15112961265031	0.522980017784063	SLC19A1/SLC25A5/SLC29A1	3
GO:1990381	ubiquitin-specific protease binding	3/1188	21/18367	0.15112961265031	0.522980017784063	VCP/CLTC/PARK7	3
GO:0000774	adenyl-nucleotide exchange factor activity	2/1188	11/18367	0.156160366031714	0.522980017784063	BAG2/SIL1	2
GO:0005049	nuclear export signal receptor activity	2/1188	11/18367	0.156160366031714	0.522980017784063	RAN/NUP214	2
GO:0005536	glucose binding	2/1188	11/18367	0.156160366031714	0.522980017784063	SLC2A3/UGP2	2
GO:0008503	benzodiazepine receptor activity	2/1188	11/18367	0.156160366031714	0.522980017784063	GABRE/TSPO	2
GO:0008603	cAMP-dependent protein kinase regulator activity	2/1188	11/18367	0.156160366031714	0.522980017784063	PKIB/CXCL10	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/1188	11/18367	0.156160366031714	0.522980017784063	P4HB/ERO1A	2
GO:0019107	myristoyltransferase activity	2/1188	11/18367	0.156160366031714	0.522980017784063	NMT1/HADHB	2
GO:0035673	oligopeptide transmembrane transporter activity	2/1188	11/18367	0.156160366031714	0.522980017784063	GJA1/SLC13A3	2
GO:0043522	leucine zipper domain binding	2/1188	11/18367	0.156160366031714	0.522980017784063	PAWR/PMF1	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/1188	11/18367	0.156160366031714	0.522980017784063	PGK1/GLRX	2
GO:0099186	structural constituent of postsynapse	2/1188	11/18367	0.156160366031714	0.522980017784063	DLG1/ACTB	2
GO:1901612	cardiolipin binding	2/1188	11/18367	0.156160366031714	0.522980017784063	MME/STOML2	2
GO:1990226	histone methyltransferase binding	2/1188	11/18367	0.156160366031714	0.522980017784063	HSP90AB1/NOP56	2
GO:0140097	catalytic activity, acting on DNA	19/1188	229/18367	0.158801087029011	0.530045099849342	SMARCA1/MCM3/HELLS/MCM6/DNMT1/SMARCA2/MCM7/DNMT3A/DHX36/DDX1/RUVBL1/ISG20/RAD50/RFC1/NME1/APEX1/RPS3/TOP2A/SMC3	19
GO:0008083	growth factor activity	14/1188	162/18367	0.164809664709468	0.545238994317818	EFEMP1/BMP7/TYMP/TIMP1/PTN/VEGFA/GMFG/TGFB1/GDF15/NENF/IGF2/RABEP1/MANF/GRN	14
GO:0004860	protein kinase inhibitor activity	7/1188	70/18367	0.165636309129677	0.545238994317818	CDKN1C/PKIB/NPM1/GMFG/CIB1/LILRB4/SOCS3	7
GO:0005355	glucose transmembrane transporter activity	3/1188	22/18367	0.167082142735634	0.545238994317818	SLC2A1/SLC5A3/SLC2A3	3
GO:0005540	hyaluronic acid binding	3/1188	22/18367	0.167082142735634	0.545238994317818	CD44/VCAN/C1QBP	3
GO:0015149	hexose transmembrane transporter activity	3/1188	22/18367	0.167082142735634	0.545238994317818	SLC2A1/SLC5A3/SLC2A3	3
GO:0070034	telomerase RNA binding	3/1188	22/18367	0.167082142735634	0.545238994317818	DHX36/NHP2/SNRPD3	3
GO:0031406	carboxylic acid binding	15/1188	176/18367	0.167177487235724	0.545238994317818	NR2F2/GLDC/FOLR1/SLC19A1/FCN1/ADH5/SESN1/S100A8/GSTP1/NDUFAB1/APOC1/SLC1A3/TYMS/GLUL/P4HA1	15
GO:0008028	monocarboxylic acid transmembrane transporter activity	6/1188	58/18367	0.170820199744542	0.551594666916729	SLC27A2/SLC16A12/MPC2/SLC5A6/SLCO2B1/SLC16A3	6
GO:0008047	enzyme activator activity	10/1188	110/18367	0.174019941001936	0.551594666916729	DDOST/NCF2/NCF1/APOE/GNAS/GMFG/APOC1/PARK7/RFC1/ARL1	10
GO:0004864	protein phosphatase inhibitor activity	5/1188	46/18367	0.174514764048493	0.551594666916729	PTN/LGALS3/PHACTR2/SET/ENSA	5
GO:0016831	carboxy-lyase activity	4/1188	34/18367	0.174886187138225	0.551594666916729	PISD/PAICS/UROD/ECHDC1	4
GO:0004896	cytokine receptor activity	9/1188	97/18367	0.175182400414869	0.551594666916729	CXCR4/CD44/PRLR/IFNGR2/IL6ST/CD74/CSF3R/IL10RB/CSF2RA	9
GO:0030165	PDZ domain binding	8/1188	84/18367	0.175417486807309	0.551594666916729	CRIM1/TGFBR3/ADRB1/GJA1/GNG12/CADM1/ATP2B1/ATP2B4	8
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/1188	12/18367	0.179743581315039	0.551594666916729	APEX1/RPS3	2
GO:0003995	acyl-CoA dehydrogenase activity	2/1188	12/18367	0.179743581315039	0.551594666916729	TECR/ACADVL	2
GO:0004875	complement receptor activity	2/1188	12/18367	0.179743581315039	0.551594666916729	FPR1/FPR3	2
GO:0005024	transforming growth factor beta-activated receptor activity	2/1188	12/18367	0.179743581315039	0.551594666916729	TGFBR3/LTBP1	2
GO:0005527	macrolide binding	2/1188	12/18367	0.179743581315039	0.551594666916729	FKBP3/FKBP2	2
GO:0008296	3'-5'-exodeoxyribonuclease activity	2/1188	12/18367	0.179743581315039	0.551594666916729	ISG20/APEX1	2
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	2/1188	12/18367	0.179743581315039	0.551594666916729	CDK6/BRD4	2
GO:0015166	polyol transmembrane transporter activity	2/1188	12/18367	0.179743581315039	0.551594666916729	SLC5A3/AQP9	2
GO:0017166	vinculin binding	2/1188	12/18367	0.179743581315039	0.551594666916729	DAG1/UTRN	2
GO:0031543	peptidyl-proline dioxygenase activity	2/1188	12/18367	0.179743581315039	0.551594666916729	P4HB/P4HA1	2
GO:0045295	gamma-catenin binding	2/1188	12/18367	0.179743581315039	0.551594666916729	CDH1/DSC3	2
GO:0061578	Lys63-specific deubiquitinase activity	2/1188	12/18367	0.179743581315039	0.551594666916729	USP27X/PSMD14	2
GO:0097677	STAT family protein binding	2/1188	12/18367	0.179743581315039	0.551594666916729	SPI1/PARP9	2
GO:0042379	chemokine receptor binding	7/1188	72/18367	0.183029277502624	0.551594666916729	STAT1/CCL3L3/JAK1/CXCL10/CXCL16/CCL4/DEFB1	7
GO:0005158	insulin receptor binding	3/1188	23/18367	0.183496422260876	0.551594666916729	SORBS1/IGF1R/IGF2	3
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	3/1188	23/18367	0.183496422260876	0.551594666916729	PIR/CDO1/ADI1	3
GO:0017116	single-stranded DNA helicase activity	3/1188	23/18367	0.183496422260876	0.551594666916729	MCM3/MCM6/MCM7	3
GO:0017134	fibroblast growth factor binding	3/1188	23/18367	0.183496422260876	0.551594666916729	TGFBR3/GPC1/S100A13	3
GO:0070412	R-SMAD binding	3/1188	23/18367	0.183496422260876	0.551594666916729	PARP1/FOS/JUN	3
GO:0140103	catalytic activity, acting on a glycoprotein	3/1188	23/18367	0.183496422260876	0.551594666916729	FUT8/C1GALT1/MGAT1	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	5/1188	47/18367	0.185658084140695	0.554750802312616	DUSP9/DUSP5/DUSP14/DUSP1/PTP4A1	5
GO:0019829	ATPase-coupled cation transmembrane transporter activity	5/1188	47/18367	0.185658084140695	0.554750802312616	ATP6V1C2/ATP2B1/ATP6V1F/ATP2B4/ATP6V1E1	5
GO:0001786	phosphatidylserine binding	6/1188	60/18367	0.190432367457659	0.566910119771148	MME/SYT7/SCIN/TREM2/HSPA8/CD300A	6
GO:0042562	hormone binding	8/1188	86/18367	0.191694906039548	0.566910119771148	LRP2/EGFR/SLC40A1/IGF1R/PRLR/CTSH/CALR/TSPO	8
GO:0015370	solute:sodium symporter activity	7/1188	73/18367	0.191999619722092	0.566910119771148	SLC6A4/SLC38A1/SLC13A4/SLC13A3/SLC5A3/SLC5A6/SLC1A3	7
GO:0140104	molecular carrier activity	7/1188	73/18367	0.191999619722092	0.566910119771148	NDUFAB1/RAN/PARK7/TNPO1/HSPA8/SCO2/NUP214	7
GO:0048020	CCR chemokine receptor binding	5/1188	48/18367	0.19705148389664	0.571635275780208	STAT1/CCL3L3/JAK1/CCL4/DEFB1	5
GO:0003727	single-stranded RNA binding	8/1188	87/18367	0.200062530416002	0.571635275780208	L1TD1/MSI2/CBX4/RBPMS/DDX1/HNRNPDL/PABPC1/SNRPC	8
GO:0003707	steroid hormone receptor activity	3/1188	24/18367	0.200312639097297	0.571635275780208	ESRRG/ESRRA/PGRMC2	3
GO:0015145	monosaccharide transmembrane transporter activity	3/1188	24/18367	0.200312639097297	0.571635275780208	SLC2A1/SLC5A3/SLC2A3	3
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3/1188	24/18367	0.200312639097297	0.571635275780208	PIR/CDO1/ADI1	3
GO:0043495	protein-membrane adaptor activity	3/1188	24/18367	0.200312639097297	0.571635275780208	SYNE2/CIB1/PDCD6	3
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	3/1188	24/18367	0.200312639097297	0.571635275780208	BMP7/PYCARD/GDF15	3
GO:0070840	dynein complex binding	3/1188	24/18367	0.200312639097297	0.571635275780208	ATMIN/CENPF/SMC3	3
GO:0019210	kinase inhibitor activity	7/1188	74/18367	0.20114232130709	0.571635275780208	CDKN1C/PKIB/NPM1/GMFG/CIB1/LILRB4/SOCS3	7
GO:0004859	phospholipase inhibitor activity	2/1188	13/18367	0.203808377523122	0.571635275780208	ANXA3/APOC1	2
GO:0008035	high-density lipoprotein particle binding	2/1188	13/18367	0.203808377523122	0.571635275780208	HSPD1/TREM2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/1188	13/18367	0.203808377523122	0.571635275780208	SLC26A2/SLC13A4	2
GO:0016840	carbon-nitrogen lyase activity	2/1188	13/18367	0.203808377523122	0.571635275780208	GGCT/APMAP	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/1188	13/18367	0.203808377523122	0.571635275780208	UBE4B/ANAPC11	2
GO:0042301	phosphate ion binding	2/1188	13/18367	0.203808377523122	0.571635275780208	GNG12/PNP	2
GO:0060590	ATPase regulator activity	2/1188	13/18367	0.203808377523122	0.571635275780208	BAG2/SIL1	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/1188	13/18367	0.203808377523122	0.571635275780208	HSD17B1/HSD17B11	2
GO:0001664	G protein-coupled receptor binding	23/1188	295/18367	0.203909978134022	0.571635275780208	ITGB4/WLS/RNF43/ADRB1/ZNRF3/FCN1/GNAI1/STAT1/GNAS/GNA11/C1QBP/CCL3L3/FLNA/FPR1/JAK1/PHB/GNAI2/CXCL10/CXCL16/CCL4/DEFB1/HSPA8/JAK2	23
GO:0019212	phosphatase inhibitor activity	5/1188	49/18367	0.208677999727767	0.583363147698351	PTN/LGALS3/PHACTR2/SET/ENSA	5
GO:0004386	helicase activity	13/1188	156/18367	0.209976420457287	0.584539858764521	SMARCA1/MCM3/HELLS/DDX3Y/MCM6/SMARCA2/MCM7/DHX36/DDX27/DDX1/RUVBL1/RAD50/DHX15	13
GO:0019003	GDP binding	7/1188	75/18367	0.210449395778411	0.584539858764521	GNAI1/GBP1/RHOA/RAN/HRAS/RRAS/RAB2A	7
GO:1990841	promoter-specific chromatin binding	6/1188	62/18367	0.210856061277783	0.584539858764521	ISL1/STAT1/DNMT1/FOXO4/KLF4/HDAC2	6
GO:0015291	secondary active transmembrane transporter activity	19/1188	240/18367	0.211509905177753	0.584728214314121	SLC26A2/SLC16A12/SLC6A4/SLC38A1/SLC22A11/SLC13A4/SLC19A1/SLC13A3/SLC9A1/SLC25A3/SLC5A3/SLC25A5/SLC5A6/SLC11A1/SLC1A3/SLCO2B1/SLC16A3/SLC25A1/SLC8A1	19
GO:0008327	methyl-CpG binding	3/1188	25/18367	0.217472476051458	0.592998718850696	DNMT1/MBD2/PRMT1	3
GO:0034237	protein kinase A regulatory subunit binding	3/1188	25/18367	0.217472476051458	0.592998718850696	AKAP9/WASF2/ACBD3	3
GO:0035035	histone acetyltransferase binding	3/1188	25/18367	0.217472476051458	0.592998718850696	GLI3/STAT1/CEBPB	3
GO:0035925	mRNA 3'-UTR AU-rich region binding	3/1188	25/18367	0.217472476051458	0.592998718850696	ZFP36/DHX36/ZFP36L1	3
GO:0051019	mitogen-activated protein kinase binding	3/1188	25/18367	0.217472476051458	0.592998718850696	DUSP1/GCH1/PRMT1	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	5/1188	50/18367	0.220520385589337	0.599671239286536	SLC19A1/SLC35B4/SLC25A5/SLC25A36/SLC29A1	5
GO:0005172	vascular endothelial growth factor receptor binding	2/1188	14/18367	0.228193967752793	0.608924010206651	VEGFA/CD2AP	2
GO:0005313	L-glutamate transmembrane transporter activity	2/1188	14/18367	0.228193967752793	0.608924010206651	SLC1A3/SLC25A13	2
GO:0015373	anion:sodium symporter activity	2/1188	14/18367	0.228193967752793	0.608924010206651	SLC6A4/SLC13A4	2
GO:0015926	glucosidase activity	2/1188	14/18367	0.228193967752793	0.608924010206651	AGL/GANAB	2
GO:0035259	glucocorticoid receptor binding	2/1188	14/18367	0.228193967752793	0.608924010206651	CEBPB/NR4A1	2
GO:0043023	ribosomal large subunit binding	2/1188	14/18367	0.228193967752793	0.608924010206651	NPM1/RBM3	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/1188	14/18367	0.228193967752793	0.608924010206651	HSD17B1/HSD17B11	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4/1188	38/18367	0.229325518731582	0.610311647184316	SIAH1/SIAH2/PARK7/RPS3	4
GO:0008198	ferrous iron binding	3/1188	26/18367	0.234919445149615	0.623536186859882	FTH1/CDO1/ISCU	3
GO:0140030	modification-dependent protein binding	13/1188	160/18367	0.236158902340154	0.625163354205502	MORC4/AGL/HSPD1/LAPTM5/CBX4/BRD4/VCP/BRD7/PTPN6/CBX5/CDYL/RAD23B/LYN	13
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	4/1188	39/18367	0.243552842499872	0.639511288168845	POLR2L/POLR2I/POLR2K/POLR2F	4
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	4/1188	39/18367	0.243552842499872	0.639511288168845	FERMT2/PHLDA3/MYO1G/IQGAP2	4
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4/1188	39/18367	0.243552842499872	0.639511288168845	DLG1/AK3/PMVK/NME1	4
GO:0004879	nuclear receptor activity	5/1188	52/18367	0.244782877836171	0.639511288168845	NR2F2/NR2F6/ESRRG/ESRRA/NR4A1	5
GO:0098531	ligand-activated transcription factor activity	5/1188	52/18367	0.244782877836171	0.639511288168845	NR2F2/NR2F6/ESRRG/ESRRA/NR4A1	5
GO:0008139	nuclear localization sequence binding	3/1188	27/18367	0.252599154653021	0.645147831966326	NFKBIA/TNPO1/NUP214	3
GO:0015491	cation:cation antiporter activity	3/1188	27/18367	0.252599154653021	0.645147831966326	SLC9A1/SLC11A1/SLC8A1	3
GO:0045499	chemorepellent activity	3/1188	27/18367	0.252599154653021	0.645147831966326	SEMA6A/SEMA6D/DPP4	3
GO:0051119	sugar transmembrane transporter activity	3/1188	27/18367	0.252599154653021	0.645147831966326	SLC2A1/SLC5A3/SLC2A3	3
GO:0005161	platelet-derived growth factor receptor binding	2/1188	15/18367	0.252758318936707	0.645147831966326	VEGFA/LYN	2
GO:0005545	1-phosphatidylinositol binding	2/1188	15/18367	0.252758318936707	0.645147831966326	SCIN/SNX10	2
GO:0019215	intermediate filament binding	2/1188	15/18367	0.252758318936707	0.645147831966326	VIM/NME1	2
GO:0051139	metal ion:proton antiporter activity	2/1188	15/18367	0.252758318936707	0.645147831966326	SLC9A1/SLC11A1	2
GO:1901611	phosphatidylglycerol binding	2/1188	15/18367	0.252758318936707	0.645147831966326	MME/STOML2	2
GO:0002039	p53 binding	6/1188	66/18367	0.253770834957415	0.646079829815051	HSPD1/TRIM29/BRD4/BRD7/SMYD2/MDM2	6
GO:1901618	organic hydroxy compound transmembrane transporter activity	5/1188	53/18367	0.257167824613754	0.651782661869834	SLC6A4/SLC5A3/SLCO2B1/SLC16A3/AQP9	5
GO:0015144	carbohydrate transmembrane transporter activity	4/1188	40/18367	0.257970091621828	0.651782661869834	SLC2A1/SLC5A3/SLC2A3/AQP9	4
GO:0017080	sodium channel regulator activity	4/1188	40/18367	0.257970091621828	0.651782661869834	FXYD3/PRSS8/FXYD5/ATP2B4	4
GO:0090079	translation regulator activity, nucleic acid binding	9/1188	108/18367	0.264069634121279	0.665508825386456	EIF1/EIF3A/EIF2S2/EIF5/PABPC1/EIF3J/TYMS/EIF5B/ABCF1	9
GO:0015101	organic cation transmembrane transporter activity	3/1188	28/18367	0.270459517240449	0.676487714801925	SLC19A3/SLC44A2/SLC29A1	3
GO:0046875	ephrin receptor binding	3/1188	28/18367	0.270459517240449	0.676487714801925	EFNA1/GRB2/LYN	3
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	3/1188	28/18367	0.270459517240449	0.676487714801925	PHLDA3/PLEKHA5/SNX3	3
GO:0048487	beta-tubulin binding	4/1188	41/18367	0.272549372918376	0.676825547596715	TBCA/LRPPRC/GABARAPL1/SMC3	4
GO:0005283	amino acid:sodium symporter activity	2/1188	16/18367	0.277376401770598	0.676825547596715	SLC38A1/SLC1A3	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/1188	16/18367	0.277376401770598	0.676825547596715	SLC1A3/SLC25A13	2
GO:0015347	sodium-independent organic anion transmembrane transporter activity	2/1188	16/18367	0.277376401770598	0.676825547596715	SLC22A11/SLCO2B1	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/1188	16/18367	0.277376401770598	0.676825547596715	SLC13A3/SLC25A13	2
GO:0016208	AMP binding	2/1188	16/18367	0.277376401770598	0.676825547596715	ACSS1/FBP1	2
GO:0017070	U6 snRNA binding	2/1188	16/18367	0.277376401770598	0.676825547596715	LSM7/LSM3	2
GO:0032183	SUMO binding	2/1188	16/18367	0.277376401770598	0.676825547596715	CBX4/SERBP1	2
GO:0035497	cAMP response element binding	2/1188	16/18367	0.277376401770598	0.676825547596715	CREB3L2/JUN	2
GO:1990404	protein ADP-ribosylase activity	2/1188	16/18367	0.277376401770598	0.676825547596715	PARP1/PARP9	2
GO:0001046	core promoter sequence-specific DNA binding	4/1188	42/18367	0.287263353686858	0.692004819948754	NPM1/STAT1/CEBPB/FOS	4
GO:0008307	structural constituent of muscle	4/1188	42/18367	0.287263353686858	0.692004819948754	DAG1/CSRP2/ASPH/KRT19	4
GO:0019205	nucleobase-containing compound kinase activity	4/1188	42/18367	0.287263353686858	0.692004819948754	DLG1/AK3/ADK/NME1	4
GO:0015301	anion:anion antiporter activity	3/1188	29/18367	0.288450906912507	0.692004819948754	SLC26A2/SLC19A1/SLC25A5	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	3/1188	29/18367	0.288450906912507	0.692004819948754	DHCR24/AKR1B1/TECR	3
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	3/1188	29/18367	0.288450906912507	0.692004819948754	NCF1/PHLDA3/MYO1G	3
GO:0051787	misfolded protein binding	3/1188	29/18367	0.288450906912507	0.692004819948754	HSPA5/SDF2/HSPA8	3
GO:0032182	ubiquitin-like protein binding	9/1188	111/18367	0.290467270390053	0.695171069182908	CXCR4/CBX4/UBE2L6/SERBP1/MDM2/CKS2/RAD23B/CKS1B/TOP2A	9
GO:0008135	translation factor activity, RNA binding	7/1188	84/18367	0.300201600669226	0.704395305648196	EIF1/EIF3A/EIF2S2/EIF5/EIF3J/EIF5B/ABCF1	7
GO:0004659	prenyltransferase activity	2/1188	17/18367	0.301938588279961	0.704395305648196	FDFT1/FDPS	2
GO:0005324	long-chain fatty acid transporter activity	2/1188	17/18367	0.301938588279961	0.704395305648196	SLC27A2/SLC2A1	2
GO:0008381	mechanosensitive ion channel activity	2/1188	17/18367	0.301938588279961	0.704395305648196	TMEM150C/TMC5	2
GO:0015095	magnesium ion transmembrane transporter activity	2/1188	17/18367	0.301938588279961	0.704395305648196	TUSC3/MRS2	2
GO:0015116	sulfate transmembrane transporter activity	2/1188	17/18367	0.301938588279961	0.704395305648196	SLC26A2/SLC13A4	2
GO:0015174	basic amino acid transmembrane transporter activity	2/1188	17/18367	0.301938588279961	0.704395305648196	SLC38A9/SLC7A7	2
GO:0030275	LRR domain binding	2/1188	17/18367	0.301938588279961	0.704395305648196	PAWR/PMF1	2
GO:0070064	proline-rich region binding	2/1188	17/18367	0.301938588279961	0.704395305648196	YAP1/CCND1	2
GO:0034062	5'-3' RNA polymerase activity	4/1188	43/18367	0.302085361540509	0.704395305648196	POLR2L/POLR2I/POLR2K/POLR2F	4
GO:0097747	RNA polymerase activity	4/1188	43/18367	0.302085361540509	0.704395305648196	POLR2L/POLR2I/POLR2K/POLR2F	4
GO:0005343	organic acid:sodium symporter activity	3/1188	30/18367	0.306526271373874	0.711426090304946	SLC38A1/SLC13A3/SLC1A3	3
GO:0022829	wide pore channel activity	3/1188	30/18367	0.306526271373874	0.711426090304946	GJA5/GJA1/VDAC1	3
GO:0004536	deoxyribonuclease activity	5/1188	57/18367	0.30799075143655	0.713166519567697	ISG20/RAD50/NME1/APEX1/RPS3	5
GO:0031491	nucleosome binding	6/1188	71/18367	0.310302015796257	0.716063380134433	SMARCA1/HMGN3/HDAC2/ACTB/MBD2/HMGN1	6
GO:0050660	flavin adenine dinucleotide binding	7/1188	85/18367	0.310676797192595	0.716063380134433	DHCR24/CYBB/ETFA/DLD/CYB5R1/ERO1A/ACADVL	7
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	32/1188	450/18367	0.313724381067978	0.721421503008853	PBX1/ISL1/TFDP2/TFCP2L1/ZFAT/GATA3/TFAP2A/EPAS1/TBX3/ESRRG/KLF5/TFAP2C/IRF6/CEBPB/DLX5/FOXO4/FOS/SOX4/ETV5/SPI1/PLSCR1/IRF1/ATF5/ATMIN/KLF4/JUNB/KLF6/NFAT5/TFEC/CREB3L2/JUN/NR4A1	32
GO:0042393	histone binding	18/1188	244/18367	0.315813116500368	0.724555150039925	MORC4/CTSL/RBBP7/CBX4/NASP/BRD4/NPM1/TBL1X/STAT1/SMARCA2/BRD7/CKS2/CBX5/CDYL/SET/CKS1B/PARP9/JAK2	18
GO:0003678	DNA helicase activity	6/1188	72/18367	0.321872264732043	0.727001086836122	MCM3/MCM6/MCM7/DHX36/RUVBL1/RAD50	6
GO:0008235	metalloexopeptidase activity	6/1188	72/18367	0.321872264732043	0.727001086836122	ENPEP/TFRC/LAP3/METAP2/CPM/ANPEP	6
GO:0031072	heat shock protein binding	10/1188	129/18367	0.323600396033445	0.727001086836122	HSP90AB1/ST13/ZFP36/GBP1/HSPA5/BAG2/TFAM/HDAC2/HSPA8/RPS3	10
GO:0005164	tumor necrosis factor receptor binding	3/1188	31/18367	0.324641205927045	0.727001086836122	STAT1/TNFSF10/TNFSF13B	3
GO:0016878	acid-thiol ligase activity	3/1188	31/18367	0.324641205927045	0.727001086836122	SLC27A2/ACSS1/SUCLG1	3
GO:0140142	nucleocytoplasmic carrier activity	3/1188	31/18367	0.324641205927045	0.727001086836122	RAN/TNPO1/NUP214	3
GO:0140318	protein transporter activity	3/1188	31/18367	0.324641205927045	0.727001086836122	LRP2/IGF1R/TIMM8B	3
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/1188	18/18367	0.326349185273129	0.727001086836122	HSD17B1/HSD17B11	2
GO:0042834	peptidoglycan binding	2/1188	18/18367	0.326349185273129	0.727001086836122	TREM2/TLR2	2
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/1188	18/18367	0.326349185273129	0.727001086836122	GCLM/AKR1B1	2
GO:0055102	lipase inhibitor activity	2/1188	18/18367	0.326349185273129	0.727001086836122	ANXA3/APOC1	2
GO:0070122	isopeptidase activity	2/1188	18/18367	0.326349185273129	0.727001086836122	PSMD14/PSMD7	2
GO:0098918	structural constituent of synapse	2/1188	18/18367	0.326349185273129	0.727001086836122	DLG1/ACTB	2
GO:0033293	monocarboxylic acid binding	6/1188	73/18367	0.333502650852337	0.739634767890294	NR2F2/ADH5/S100A8/GSTP1/NDUFAB1/APOC1	6
GO:0070063	RNA polymerase binding	6/1188	73/18367	0.333502650852337	0.739634767890294	BRD4/ZFP36/PPIB/SMYD2/NCOA3/RTF1	6
GO:0004721	phosphoprotein phosphatase activity	13/1188	174/18367	0.336133937634705	0.743817449577463	DUSP9/CTDSPL/PTPN14/DUSP5/DUSP14/DUSP1/DLG1/PGP/PTPRC/CAMK2G/PTPN6/PTPRA/PTP4A1	13
GO:0001216	DNA-binding transcription activator activity	32/1188	456/18367	0.341228966203812	0.751798870921567	PBX1/ISL1/TFDP2/TFCP2L1/ZFAT/GATA3/TFAP2A/EPAS1/TBX3/ESRRG/KLF5/TFAP2C/IRF6/CEBPB/DLX5/FOXO4/FOS/SOX4/ETV5/SPI1/PLSCR1/IRF1/ATF5/ATMIN/KLF4/JUNB/KLF6/NFAT5/TFEC/CREB3L2/JUN/NR4A1	32
GO:0001223	transcription coactivator binding	3/1188	32/18367	0.342753994257829	0.751798870921567	EPAS1/RPL23/TFAM	3
GO:0050699	WW domain binding	3/1188	32/18367	0.342753994257829	0.751798870921567	TCEAL4/NDFIP2/TCEAL8	3
GO:0140658	ATP-dependent chromatin remodeler activity	3/1188	32/18367	0.342753994257829	0.751798870921567	SMARCA1/HELLS/SMARCA2	3
GO:0061980	regulatory RNA binding	4/1188	46/18367	0.346944466252241	0.75932144149065	KCNQ1OT1/SOX4/YBX1/MBD2	4
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/1188	19/18367	0.350525092828556	0.763807953368775	TGFBR3/LTBP1	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/1188	19/18367	0.350525092828556	0.763807953368775	SLC6A4/SLC29A1	2
GO:0015294	solute:cation symporter activity	8/1188	104/18367	0.359078147492291	0.777762353478952	SLC6A4/SLC38A1/SLC13A4/SLC13A3/SLC25A3/SLC5A3/SLC5A6/SLC1A3	8
GO:0015179	L-amino acid transmembrane transporter activity	5/1188	61/18367	0.360052019373656	0.777762353478952	SLC38A1/SLC38A9/SLC1A3/SLC25A13/SLC7A7	5
GO:0031369	translation initiation factor binding	3/1188	33/18367	0.36082562090256	0.777762353478952	EIF2S2/EIF5/GCH1	3
GO:0051427	hormone receptor binding	3/1188	33/18367	0.36082562090256	0.777762353478952	GNAS/JAK1/JAK2	3
GO:0140323	solute:anion antiporter activity	3/1188	33/18367	0.36082562090256	0.777762353478952	SLC26A2/SLC19A1/SLC25A5	3
GO:0005044	scavenger receptor activity	4/1188	47/18367	0.36194785063471	0.778499902873794	COLEC12/CXCL16/LRP1/LGALS3BP	4
GO:0004197	cysteine-type endopeptidase activity	9/1188	119/18367	0.36359441205544	0.78035961985232	CTSV/CTSL/CTSS/CTSH/LGMN/GPAA1/PYCARD/USP14/USP47	9
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/1188	20/18367	0.374394577797729	0.797599409566749	GLDC/IL4I1	2
GO:0030296	protein tyrosine kinase activator activity	2/1188	20/18367	0.374394577797729	0.797599409566749	ERBB3/CD24	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/1188	20/18367	0.374394577797729	0.797599409566749	KLF4/SOCS3	2
GO:0043177	organic acid binding	10/1188	135/18367	0.375910833596318	0.797599409566749	NR2F2/GLDC/FOLR1/SLC19A1/ASS1/S100A8/SLC1A3/TYMS/GLUL/P4HA1	10
GO:0140677	molecular function activator activity	11/1188	150/18367	0.378255074238678	0.797599409566749	DDOST/NCF2/NCF1/APOE/GNAS/DNAJB4/GMFG/APOC1/PARK7/RFC1/ARL1	11
GO:0008376	acetylgalactosaminyltransferase activity	3/1188	34/18367	0.378819759653947	0.797599409566749	CHPF/EXTL2/GALNT11	3
GO:0030291	protein serine/threonine kinase inhibitor activity	3/1188	34/18367	0.378819759653947	0.797599409566749	CDKN1C/PKIB/CIB1	3
GO:0035198	miRNA binding	3/1188	34/18367	0.378819759653947	0.797599409566749	KCNQ1OT1/SOX4/YBX1	3
GO:0043548	phosphatidylinositol 3-kinase binding	3/1188	34/18367	0.378819759653947	0.797599409566749	IGF1R/HCST/JAK2	3
GO:0016874	ligase activity	12/1188	165/18367	0.380102618542908	0.798615606959626	SLC27A2/ACSS1/ASS1/IARS2/GCLM/PCCB/RIMKLB/ASNSD1/PAICS/MDM2/SUCLG1/GLUL	12
GO:0030546	signaling receptor activator activity	34/1188	495/18367	0.382812480963953	0.802619445382405	FBN1/SEMA6A/SEMA6D/EFEMP1/DPP4/BMP7/TYMP/FAM3B/APP/TIMP1/CMTM8/PTN/INSL4/LRPAP1/VEGFA/CCL3L3/LGALS3/GMFG/TNFSF10/TNFSF13B/TGFB1/GDF15/SECTM1/RETN/NENF/IGF2/FAM3C/CXCL10/RABEP1/CXCL16/CCL4/CGA/MANF/GRN	34
GO:0043130	ubiquitin binding	7/1188	92/18367	0.385397029886739	0.806344309909781	CXCR4/UBE2L6/MDM2/CKS2/RAD23B/CKS1B/TOP2A	7
GO:0008009	chemokine activity	4/1188	49/18367	0.391894912069197	0.812445965952235	CCL3L3/CXCL10/CXCL16/CCL4	4
GO:0043539	protein serine/threonine kinase activator activity	4/1188	49/18367	0.391894912069197	0.812445965952235	CKS2/IGF2/CKS1B/CCNB1	4
GO:0001221	transcription coregulator binding	6/1188	78/18367	0.392155218788973	0.812445965952235	EPAS1/RPL23/STAT1/TFAM/KLF4/LMO2	6
GO:0015298	solute:cation antiporter activity	3/1188	35/18367	0.396702741681743	0.812445965952235	SLC9A1/SLC11A1/SLC8A1	3
GO:0005243	gap junction channel activity	2/1188	21/18367	0.397896153076405	0.812445965952235	GJA5/GJA1	2
GO:0015662	P-type ion transporter activity	2/1188	21/18367	0.397896153076405	0.812445965952235	ATP2B1/ATP2B4	2
GO:0051010	microtubule plus-end binding	2/1188	21/18367	0.397896153076405	0.812445965952235	CLIP1/DST	2
GO:0051428	peptide hormone receptor binding	2/1188	21/18367	0.397896153076405	0.812445965952235	GNAS/JAK2	2
GO:0070577	lysine-acetylated histone binding	2/1188	21/18367	0.397896153076405	0.812445965952235	BRD4/BRD7	2
GO:0140033	acetylation-dependent protein binding	2/1188	21/18367	0.397896153076405	0.812445965952235	BRD4/BRD7	2
GO:0140358	P-type transmembrane transporter activity	2/1188	21/18367	0.397896153076405	0.812445965952235	ATP2B1/ATP2B4	2
GO:0016887	ATP hydrolysis activity	19/1188	272/18367	0.398082241834312	0.812445965952235	HSPD1/RHOBTB3/MCM3/DDX3Y/HSP90AA1/MCM6/ATP2B1/HSPA5/ATP10D/VCP/MCM7/DHX36/DDX27/DDX1/ATP2B4/RUVBL1/RNF213/DHX15/HSPA8	19
GO:0000993	RNA polymerase II complex binding	4/1188	50/18367	0.406797044806576	0.826850205126197	BRD4/SMYD2/NCOA3/RTF1	4
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4/1188	50/18367	0.406797044806576	0.826850205126197	TLR2/OARD1/DNPH1/APEX1	4
GO:0042626	ATPase-coupled transmembrane transporter activity	8/1188	109/18367	0.408965977493351	0.828311764255626	SLC26A2/ATP6V1C2/ATP2B1/ATP6V1F/ATP2B4/TAP1/TAPBP/ATP6V1E1	8
GO:0030145	manganese ion binding	5/1188	65/18367	0.412335245435325	0.828311764255626	EXTL2/SOD2/LAP3/GLUL/MGAT1	5
GO:0015248	sterol transporter activity	3/1188	36/18367	0.414443506711054	0.828311764255626	APOE/OSBPL9/TSPO	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	3/1188	36/18367	0.414443506711054	0.828311764255626	APOBEC3A/ATIC/GCH1	3
GO:0042162	telomeric DNA binding	3/1188	36/18367	0.414443506711054	0.828311764255626	RAD50/NCL/APEX1	3
GO:0042805	actinin binding	3/1188	36/18367	0.414443506711054	0.828311764255626	DAG1/CSRP2/PDLIM1	3
GO:0048018	receptor ligand activity	33/1188	487/18367	0.416255129615669	0.828311764255626	FBN1/SEMA6A/SEMA6D/EFEMP1/DPP4/BMP7/TYMP/FAM3B/TIMP1/CMTM8/PTN/INSL4/LRPAP1/VEGFA/CCL3L3/LGALS3/GMFG/TNFSF10/TNFSF13B/TGFB1/GDF15/SECTM1/RETN/NENF/IGF2/FAM3C/CXCL10/RABEP1/CXCL16/CCL4/CGA/MANF/GRN	33
GO:0005416	amino acid:cation symporter activity	2/1188	22/18367	0.420977554110482	0.828311764255626	SLC38A1/SLC1A3	2
GO:0005537	mannose binding	2/1188	22/18367	0.420977554110482	0.828311764255626	LMAN1/BSG	2
GO:0008093	cytoskeletal anchor activity	2/1188	22/18367	0.420977554110482	0.828311764255626	ANK3/OBSL1	2
GO:0015296	anion:cation symporter activity	2/1188	22/18367	0.420977554110482	0.828311764255626	SLC6A4/SLC13A4	2
GO:0016881	acid-amino acid ligase activity	2/1188	22/18367	0.420977554110482	0.828311764255626	GCLM/PAICS	2
GO:0017075	syntaxin-1 binding	2/1188	22/18367	0.420977554110482	0.828311764255626	SLC6A4/STXBP2	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2/1188	22/18367	0.420977554110482	0.828311764255626	PRDX5/PRDX3	2
GO:0070182	DNA polymerase binding	2/1188	22/18367	0.420977554110482	0.828311764255626	HSP90AB1/HSP90AA1	2
GO:0120020	cholesterol transfer activity	2/1188	22/18367	0.420977554110482	0.828311764255626	APOE/TSPO	2
GO:0051018	protein kinase A binding	4/1188	51/18367	0.421625627496852	0.828311764255626	AKAP9/WASF2/ACBD3/RPS3	4
GO:0042056	chemoattractant activity	3/1188	37/18367	0.43201354021093	0.845391202216683	VEGFA/LGALS3/CXCL10	3
GO:0071949	FAD binding	3/1188	37/18367	0.43201354021093	0.845391202216683	DHCR24/CYB5R1/ERO1A	3
GO:0016597	amino acid binding	4/1188	52/18367	0.436362523301909	0.847955193896538	GLDC/ASS1/SLC1A3/GLUL	4
GO:0003950	NAD+ ADP-ribosyltransferase activity	2/1188	23/18367	0.443594804762825	0.847955193896538	PARP1/PARP9	2
GO:0004529	exodeoxyribonuclease activity	2/1188	23/18367	0.443594804762825	0.847955193896538	ISG20/APEX1	2
GO:0015299	solute:proton antiporter activity	2/1188	23/18367	0.443594804762825	0.847955193896538	SLC9A1/SLC11A1	2
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/1188	23/18367	0.443594804762825	0.847955193896538	ISG20/APEX1	2
GO:0017025	TBP-class protein binding	2/1188	23/18367	0.443594804762825	0.847955193896538	TAF11/RUVBL1	2
GO:0030215	semaphorin receptor binding	2/1188	23/18367	0.443594804762825	0.847955193896538	SEMA6A/SEMA6D	2
GO:0120015	sterol transfer activity	2/1188	23/18367	0.443594804762825	0.847955193896538	APOE/TSPO	2
GO:0004520	endodeoxyribonuclease activity	3/1188	38/18367	0.449386799194874	0.847955193896538	RAD50/APEX1/RPS3	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	4/1188	53/18367	0.450990661970329	0.847955193896538	SLC19A1/SLC35B4/SLC25A5/SLC29A1	4
GO:0003684	damaged DNA binding	5/1188	68/18367	0.45114680014892	0.847955193896538	DDB1/RPA3/RAD23B/APEX1/RPS3	5
GO:0005125	cytokine activity	16/1188	235/18367	0.453147001692248	0.847955193896538	BMP7/FAM3B/TIMP1/CMTM8/VEGFA/CCL3L3/TNFSF10/TNFSF13B/TGFB1/GDF15/SECTM1/FAM3C/CXCL10/CXCL16/CCL4/GRN	16
GO:0015293	symporter activity	10/1188	144/18367	0.455386101988112	0.847955193896538	SLC16A12/SLC6A4/SLC38A1/SLC13A4/SLC13A3/SLC25A3/SLC5A3/SLC5A6/SLC1A3/SLC16A3	10
GO:0016798	hydrolase activity, acting on glycosyl bonds	10/1188	144/18367	0.455386101988112	0.847955193896538	LYZ/AGL/FUCA1/MAN1A2/GANAB/TLR2/FUCA2/OARD1/DNPH1/APEX1	10
GO:0008234	cysteine-type peptidase activity	13/1188	190/18367	0.458315578841897	0.847955193896538	CTSV/CTSL/CTSS/USP27X/GGH/CTSH/PSMD14/LGMN/GPAA1/USP22/PYCARD/USP14/USP47	13
GO:0008237	metallopeptidase activity	13/1188	190/18367	0.458315578841897	0.847955193896538	ADAMTS6/ADAMTS1/ENPEP/MME/TFRC/PSMD14/LAP3/AFG3L2/PMPCB/METAP2/CPM/ANPEP/ADAM8	13
GO:0008408	3'-5' exonuclease activity	4/1188	54/18367	0.465494037328713	0.847955193896538	REXO2/ISG20/RAD50/APEX1	4
GO:0001965	G-protein alpha-subunit binding	2/1188	24/18367	0.465711365277873	0.847955193896538	RGS10/RGS19	2
GO:0016769	transferase activity, transferring nitrogenous groups	2/1188	24/18367	0.465711365277873	0.847955193896538	GAPDH/GFPT1	2
GO:0019789	SUMO transferase activity	2/1188	24/18367	0.465711365277873	0.847955193896538	CBX4/MDM2	2
GO:0019957	C-C chemokine binding	2/1188	24/18367	0.465711365277873	0.847955193896538	CXCR4/ZFP36	2
GO:0043274	phospholipase binding	2/1188	24/18367	0.465711365277873	0.847955193896538	PRKCZ/SYK	2
GO:0050431	transforming growth factor beta binding	2/1188	24/18367	0.465711365277873	0.847955193896538	TGFBR3/LTBP1	2
GO:0005496	steroid binding	7/1188	100/18367	0.471085551879554	0.847955193896538	HSD17B1/ESRRG/ESRRA/OSBPL9/PGRMC2/TSPO/VDAC1	7
GO:0001098	basal transcription machinery binding	5/1188	70/18367	0.47664316468869	0.847955193896538	BRD4/RUVBL1/SMYD2/NCOA3/RTF1	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/1188	70/18367	0.47664316468869	0.847955193896538	BRD4/RUVBL1/SMYD2/NCOA3/RTF1	5
GO:0003925	G protein activity	3/1188	40/18367	0.48345067248413	0.847955193896538	RHOA/HRAS/RAB11A	3
GO:0005112	Notch binding	2/1188	25/18367	0.487297355645387	0.847955193896538	AAK1/GALNT11	2
GO:0005227	calcium activated cation channel activity	2/1188	25/18367	0.487297355645387	0.847955193896538	KCNN4/CATSPER1	2
GO:0008266	poly(U) RNA binding	2/1188	25/18367	0.487297355645387	0.847955193896538	MSI2/PABPC1	2
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/1188	10/18367	0.487701684665945	0.847955193896538	RAD50	1
GO:0001094	TFIID-class transcription factor complex binding	1/1188	10/18367	0.487701684665945	0.847955193896538	RUVBL1	1
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/1188	10/18367	0.487701684665945	0.847955193896538	APEX1	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	PRKACB	1
GO:0004955	prostaglandin receptor activity	1/1188	10/18367	0.487701684665945	0.847955193896538	HPGD	1
GO:0005031	tumor necrosis factor-activated receptor activity	1/1188	10/18367	0.487701684665945	0.847955193896538	TNFRSF1B	1
GO:0005432	calcium:sodium antiporter activity	1/1188	10/18367	0.487701684665945	0.847955193896538	SLC8A1	1
GO:0008239	dipeptidyl-peptidase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	DPP4	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/1188	10/18367	0.487701684665945	0.847955193896538	SLC35B4	1
GO:0015232	heme transmembrane transporter activity	1/1188	10/18367	0.487701684665945	0.847955193896538	PGRMC2	1
GO:0015643	toxic substance binding	1/1188	10/18367	0.487701684665945	0.847955193896538	ASS1	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	MAN1A2	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	PIK3C2A	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/1188	10/18367	0.487701684665945	0.847955193896538	CYB5R1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/1188	10/18367	0.487701684665945	0.847955193896538	DEGS1	1
GO:0016783	sulfurtransferase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	TSTD1	1
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1/1188	10/18367	0.487701684665945	0.847955193896538	ASNSD1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/1188	10/18367	0.487701684665945	0.847955193896538	ADH5	1
GO:0019203	carbohydrate phosphatase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	FBP1	1
GO:0019531	oxalate transmembrane transporter activity	1/1188	10/18367	0.487701684665945	0.847955193896538	SLC26A2	1
GO:0031078	histone deacetylase activity (H3-K14 specific)	1/1188	10/18367	0.487701684665945	0.847955193896538	HDAC2	1
GO:0031419	cobalamin binding	1/1188	10/18367	0.487701684665945	0.847955193896538	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	SLC27A2	1
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	1/1188	10/18367	0.487701684665945	0.847955193896538	HDAC2	1
GO:0032356	oxidized DNA binding	1/1188	10/18367	0.487701684665945	0.847955193896538	RPS3	1
GO:0035374	chondroitin sulfate binding	1/1188	10/18367	0.487701684665945	0.847955193896538	PTN	1
GO:0035612	AP-2 adaptor complex binding	1/1188	10/18367	0.487701684665945	0.847955193896538	AAK1	1
GO:0043139	5'-3' DNA helicase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	RUVBL1	1
GO:0043208	glycosphingolipid binding	1/1188	10/18367	0.487701684665945	0.847955193896538	LYN	1
GO:0045503	dynein light chain binding	1/1188	10/18367	0.487701684665945	0.847955193896538	GLUL	1
GO:0047844	deoxycytidine deaminase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	APOBEC3A	1
GO:0050308	sugar-phosphatase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	FBP1	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/1188	10/18367	0.487701684665945	0.847955193896538	PIK3C2A	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/1188	10/18367	0.487701684665945	0.847955193896538	ADRB1	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/1188	56/18367	0.494067743011399	0.84936945244495	PRDX5/CST3/PRDX3/CST6	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/1188	41/18367	0.500100775081427	0.84936945244495	SLC27A2/ACSS1/SUCLG1	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	3/1188	41/18367	0.500100775081427	0.84936945244495	COL14A1/COL4A2/COL21A1	3
GO:0030331	estrogen receptor binding	3/1188	41/18367	0.500100775081427	0.84936945244495	ISL1/PARP1/FUS	3
GO:0043175	RNA polymerase core enzyme binding	4/1188	57/18367	0.508111289545349	0.84936945244495	BRD4/SMYD2/NCOA3/RTF1	4
GO:0030371	translation repressor activity	2/1188	26/18367	0.508328848186702	0.84936945244495	TYMS/CIRBP	2
GO:0097602	cullin family protein binding	2/1188	26/18367	0.508328848186702	0.84936945244495	DDB1/ANAPC11	2
GO:0031267	small GTPase binding	17/1188	259/18367	0.511215702017291	0.84936945244495	EXPH5/RHOBTB3/SOD1/NCF2/GOLGA4/FLNA/EPS8/CIB1/RANBP1/YIPF2/CCDC186/TRIOBP/ARHGDIB/TNPO1/FMNL1/IQGAP2/SORL1	17
GO:0106306	protein serine phosphatase activity	5/1188	73/18367	0.514105296322534	0.84936945244495	DUSP9/CTDSPL/DUSP5/DUSP14/DUSP1	5
GO:0106307	protein threonine phosphatase activity	5/1188	73/18367	0.514105296322534	0.84936945244495	DUSP9/CTDSPL/DUSP5/DUSP14/DUSP1	5
GO:0051539	4 iron, 4 sulfur cluster binding	3/1188	42/18367	0.516472884419471	0.84936945244495	RSAD2/ACO2/NDUFS8	3
GO:0015297	antiporter activity	6/1188	89/18367	0.518992598742734	0.84936945244495	SLC26A2/SLC19A1/SLC9A1/SLC25A5/SLC11A1/SLC8A1	6
GO:0051117	ATPase binding	6/1188	89/18367	0.518992598742734	0.84936945244495	EGFR/SNX10/UBE4B/SNU13/RUVBL1/ATP6V1E1	6
GO:0002162	dystroglycan binding	1/1188	11/18367	0.520855816529368	0.84936945244495	DAG1	1
GO:0004596	peptide alpha-N-acetyltransferase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	NAA10	1
GO:0004954	prostanoid receptor activity	1/1188	11/18367	0.520855816529368	0.84936945244495	HPGD	1
GO:0005347	ATP transmembrane transporter activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC25A5	1
GO:0008199	ferric iron binding	1/1188	11/18367	0.520855816529368	0.84936945244495	FTH1	1
GO:0010485	H4 histone acetyltransferase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	USP22	1
GO:0015368	calcium:cation antiporter activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC8A1	1
GO:0015378	sodium:chloride symporter activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC9A1	1
GO:0016273	arginine N-methyltransferase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	PRMT1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	PRMT1	1
GO:0016832	aldehyde-lyase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	ALDOA	1
GO:0017128	phospholipid scramblase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	PLSCR1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/1188	11/18367	0.520855816529368	0.84936945244495	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/1188	11/18367	0.520855816529368	0.84936945244495	DLG1	1
GO:0035197	siRNA binding	1/1188	11/18367	0.520855816529368	0.84936945244495	MBD2	1
GO:0043295	glutathione binding	1/1188	11/18367	0.520855816529368	0.84936945244495	PTGES	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/1188	11/18367	0.520855816529368	0.84936945244495	SMYD2	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	DUT	1
GO:0047676	arachidonate-CoA ligase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC27A2	1
GO:0051400	BH domain binding	1/1188	11/18367	0.520855816529368	0.84936945244495	BCL2A1	1
GO:0061665	SUMO ligase activity	1/1188	11/18367	0.520855816529368	0.84936945244495	CBX4	1
GO:0097371	MDM2/MDM4 family protein binding	1/1188	11/18367	0.520855816529368	0.84936945244495	RPL37	1
GO:0140036	ubiquitin-dependent protein binding	1/1188	11/18367	0.520855816529368	0.84936945244495	LAPTM5	1
GO:1901474	azole transmembrane transporter activity	1/1188	11/18367	0.520855816529368	0.84936945244495	SLC19A3	1
GO:0019905	syntaxin binding	5/1188	74/18367	0.526346150877843	0.854368890441929	SLC6A4/SYT7/STXBP2/TMED9/RAB11A	5
GO:0004709	MAP kinase kinase kinase activity	2/1188	27/18367	0.528787223669396	0.854368890441929	EGFR/MAP3K2	2
GO:0016405	CoA-ligase activity	2/1188	27/18367	0.528787223669396	0.854368890441929	SLC27A2/ACSS1	2
GO:0035255	ionotropic glutamate receptor binding	2/1188	27/18367	0.528787223669396	0.854368890441929	GNAS/FUS	2
GO:0051393	alpha-actinin binding	2/1188	27/18367	0.528787223669396	0.854368890441929	DAG1/PDLIM1	2
GO:0032266	phosphatidylinositol-3-phosphate binding	3/1188	43/18367	0.532551948635393	0.854368890441929	PHLDA3/PLEKHA5/SNX3	3
GO:0019209	kinase activator activity	7/1188	107/18367	0.543480580794314	0.854368890441929	ERBB3/CD24/CKS2/TREM2/IGF2/CKS1B/CCNB1	7
GO:1902936	phosphatidylinositol bisphosphate binding	7/1188	107/18367	0.543480580794314	0.854368890441929	SYT7/SCIN/SLC9A1/PHLDA3/PLEKHA5/MYO1G/SNX3	7
GO:0008187	poly-pyrimidine tract binding	2/1188	28/18367	0.548658585702392	0.854368890441929	MSI2/PABPC1	2
GO:0050681	androgen receptor binding	2/1188	28/18367	0.548658585702392	0.854368890441929	PARK7/CALR	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	4/1188	60/18367	0.549129141168562	0.854368890441929	DHCR24/AKR1B1/TECR/ACADVL	4
GO:0000340	RNA 7-methylguanosine cap binding	1/1188	12/18367	0.551866019730671	0.854368890441929	NCBP3	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/1188	12/18367	0.551866019730671	0.854368890441929	AKR1B1	1
GO:0004126	cytidine deaminase activity	1/1188	12/18367	0.551866019730671	0.854368890441929	APOBEC3A	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/1188	12/18367	0.551866019730671	0.854368890441929	CDKN1C	1
GO:0005095	GTPase inhibitor activity	1/1188	12/18367	0.551866019730671	0.854368890441929	IQGAP2	1
GO:0005165	neurotrophin receptor binding	1/1188	12/18367	0.551866019730671	0.854368890441929	GRB2	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/1188	12/18367	0.551866019730671	0.854368890441929	SLC35B4	1
GO:0008174	mRNA methyltransferase activity	1/1188	12/18367	0.551866019730671	0.854368890441929	RNMT	1
GO:0015269	calcium-activated potassium channel activity	1/1188	12/18367	0.551866019730671	0.854368890441929	KCNN4	1
GO:0030955	potassium ion binding	1/1188	12/18367	0.551866019730671	0.854368890441929	PKM	1
GO:0033130	acetylcholine receptor binding	1/1188	12/18367	0.551866019730671	0.854368890441929	JAK2	1
GO:0034452	dynactin binding	1/1188	12/18367	0.551866019730671	0.854368890441929	SNX6	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/1188	12/18367	0.551866019730671	0.854368890441929	PIK3C2A	1
GO:0042975	peroxisome proliferator activated receptor binding	1/1188	12/18367	0.551866019730671	0.854368890441929	MDM2	1
GO:0043047	single-stranded telomeric DNA binding	1/1188	12/18367	0.551866019730671	0.854368890441929	RAD50	1
GO:0043176	amine binding	1/1188	12/18367	0.551866019730671	0.854368890441929	SLC6A4	1
GO:0043422	protein kinase B binding	1/1188	12/18367	0.551866019730671	0.854368890441929	BAD	1
GO:0046790	virion binding	1/1188	12/18367	0.551866019730671	0.854368890441929	PPIA	1
GO:0051378	serotonin binding	1/1188	12/18367	0.551866019730671	0.854368890441929	SLC6A4	1
GO:1900750	oligopeptide binding	1/1188	12/18367	0.551866019730671	0.854368890441929	PTGES	1
GO:0051213	dioxygenase activity	6/1188	92/18367	0.551902648006982	0.854368890441929	PIR/P4HB/CDO1/ADI1/ASPH/P4HA1	6
GO:0015631	tubulin binding	24/1188	375/18367	0.55217227889283	0.854368890441929	DAG1/GJA1/ALDOA/BEX4/GAPDH/CAPN6/CNN3/GPAA1/S100A8/CLIP1/TBCA/MX1/MX2/ATF5/LRPPRC/DST/CENPF/STMN1/NME1/RAB11A/RPS3/GABARAPL1/SMC3/LYN	24
GO:0003724	RNA helicase activity	5/1188	77/18367	0.562214601883707	0.868560638823436	DDX3Y/DHX36/DDX27/DDX1/DHX15	5
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2/1188	29/18367	0.567933228575717	0.870434056458665	CDK6/CCND3	2
GO:0046625	sphingolipid binding	2/1188	29/18367	0.567933228575717	0.870434056458665	VDAC1/LYN	2
GO:0070273	phosphatidylinositol-4-phosphate binding	2/1188	29/18367	0.567933228575717	0.870434056458665	PLEKHA5/SNX3	2
GO:0097472	cyclin-dependent protein kinase activity	2/1188	29/18367	0.567933228575717	0.870434056458665	CDK6/CCND3	2
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	6/1188	94/18367	0.573259580486996	0.870434056458665	LYZ/AGL/FUCA1/MAN1A2/GANAB/FUCA2	6
GO:0002161	aminoacyl-tRNA editing activity	1/1188	13/18367	0.580870823247967	0.870434056458665	IARS2	1
GO:0005035	death receptor activity	1/1188	13/18367	0.580870823247967	0.870434056458665	TNFRSF1B	1
GO:0008195	phosphatidate phosphatase activity	1/1188	13/18367	0.580870823247967	0.870434056458665	PLPP3	1
GO:0008417	fucosyltransferase activity	1/1188	13/18367	0.580870823247967	0.870434056458665	FUT8	1
GO:0008494	translation activator activity	1/1188	13/18367	0.580870823247967	0.870434056458665	PABPC1	1
GO:0015250	water channel activity	1/1188	13/18367	0.580870823247967	0.870434056458665	AQP9	1
GO:0015385	sodium:proton antiporter activity	1/1188	13/18367	0.580870823247967	0.870434056458665	SLC9A1	1
GO:0016594	glycine binding	1/1188	13/18367	0.580870823247967	0.870434056458665	GLDC	1
GO:0019104	DNA N-glycosylase activity	1/1188	13/18367	0.580870823247967	0.870434056458665	APEX1	1
GO:0022851	GABA-gated chloride ion channel activity	1/1188	13/18367	0.580870823247967	0.870434056458665	GABRE	1
GO:0045159	myosin II binding	1/1188	13/18367	0.580870823247967	0.870434056458665	TRIOBP	1
GO:0052650	NADP-retinol dehydrogenase activity	1/1188	13/18367	0.580870823247967	0.870434056458665	AKR1B1	1
GO:0061783	peptidoglycan muralytic activity	1/1188	13/18367	0.580870823247967	0.870434056458665	LYZ	1
GO:0140035	ubiquitination-like modification-dependent protein binding	1/1188	13/18367	0.580870823247967	0.870434056458665	LAPTM5	1
GO:0140299	small molecule sensor activity	1/1188	13/18367	0.580870823247967	0.870434056458665	PARK7	1
GO:0008186	ATP-dependent activity, acting on RNA	5/1188	79/18367	0.585345868913019	0.87377902057008	DDX3Y/DHX36/DDX27/DDX1/DHX15	5
GO:0017147	Wnt-protein binding	2/1188	30/18367	0.586605154090134	0.87377902057008	WLS/LRP5	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/1188	30/18367	0.586605154090134	0.87377902057008	HSD17B1/HSD17B11	2
GO:0070566	adenylyltransferase activity	2/1188	30/18367	0.586605154090134	0.87377902057008	OAS1/OAS2	2
GO:0035091	phosphatidylinositol binding	17/1188	271/18367	0.588061504105703	0.87464289284276	PHLDA2/SYT7/FERMT2/SCIN/SNX10/NCF1/SLC9A1/SH3YL1/PHLDA3/PLEKHA5/PXDC1/GPAA1/PIK3C2A/MYO1G/SNX6/IQGAP2/SNX3	17
GO:0004527	exonuclease activity	5/1188	80/18367	0.596659234661973	0.882628770618387	REXO2/DDX1/ISG20/RAD50/APEX1	5
GO:0008157	protein phosphatase 1 binding	2/1188	31/18367	0.604671633273795	0.882628770618387	LILRB2/LILRB1	2
GO:0031210	phosphatidylcholine binding	2/1188	31/18367	0.604671633273795	0.882628770618387	APOC1/VDAC1	2
GO:0042910	xenobiotic transmembrane transporter activity	2/1188	31/18367	0.604671633273795	0.882628770618387	SLC2A1/SLC19A1	2
GO:0043015	gamma-tubulin binding	2/1188	31/18367	0.604671633273795	0.882628770618387	NME1/LYN	2
GO:0004065	arylsulfatase activity	1/1188	14/18367	0.607999812132211	0.882628770618387	SULF2	1
GO:0004089	carbonate dehydratase activity	1/1188	14/18367	0.607999812132211	0.882628770618387	CA8	1
GO:0005451	monovalent cation:proton antiporter activity	1/1188	14/18367	0.607999812132211	0.882628770618387	SLC9A1	1
GO:0015562	efflux transmembrane transporter activity	1/1188	14/18367	0.607999812132211	0.882628770618387	GJA1	1
GO:0017110	nucleoside-diphosphatase activity	1/1188	14/18367	0.607999812132211	0.882628770618387	NUDT5	1
GO:0036041	long-chain fatty acid binding	1/1188	14/18367	0.607999812132211	0.882628770618387	S100A8	1
GO:0044548	S100 protein binding	1/1188	14/18367	0.607999812132211	0.882628770618387	S100A6	1
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	1/1188	14/18367	0.607999812132211	0.882628770618387	GPR34	1
GO:0140666	annealing activity	1/1188	14/18367	0.607999812132211	0.882628770618387	SMARCA1	1
GO:0004722	protein serine/threonine phosphatase activity	6/1188	98/18367	0.614392495590585	0.882628770618387	DUSP9/CTDSPL/DUSP5/DUSP14/DUSP1/CAMK2G	6
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	5/1188	82/18367	0.618756660853797	0.882628770618387	SYT7/SCIN/SLC9A1/PHLDA3/MYO1G	5
GO:0031624	ubiquitin conjugating enzyme binding	2/1188	32/18367	0.622132809208193	0.882628770618387	SIAH1/SIAH2	2
GO:0051721	protein phosphatase 2A binding	2/1188	32/18367	0.622132809208193	0.882628770618387	STAT1/ENSA	2
GO:0032813	tumor necrosis factor receptor superfamily binding	3/1188	49/18367	0.622255475346251	0.882628770618387	STAT1/TNFSF10/TNFSF13B	3
GO:0034212	peptide N-acetyltransferase activity	3/1188	49/18367	0.622255475346251	0.882628770618387	USP22/NCOA3/NAA10	3
GO:0016779	nucleotidyltransferase activity	8/1188	132/18367	0.626642366124254	0.882628770618387	POLR2L/OAS1/OAS2/POLR2I/NUDT5/POLR2K/UGP2/POLR2F	8
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	19/1188	310/18367	0.630154211577426	0.882628770618387	PEG3/NFE2L3/GATA3/TFAP2A/IRX2/NR2F6/TBX3/HIC2/TFAP2C/CEBPB/SKIL/SPI1/BHLHE41/ENO1/CREM/TFEC/IFI16/JUN/ZEB2	19
GO:0046906	tetrapyrrole binding	9/1188	149/18367	0.632348119982206	0.882628770618387	CYBA/CYBB/HEBP2/CYB5A/EIF2AK1/MTR/PGRMC2/CYCS/JAK2	9
GO:0004467	long-chain fatty acid-CoA ligase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	MAN1A2	1
GO:0004953	icosanoid receptor activity	1/1188	15/18367	0.633374204503318	0.882628770618387	HPGD	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/1188	15/18367	0.633374204503318	0.882628770618387	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/1188	15/18367	0.633374204503318	0.882628770618387	SLC22A11	1
GO:0008020	G protein-coupled photoreceptor activity	1/1188	15/18367	0.633374204503318	0.882628770618387	OPN3	1
GO:0010851	cyclase regulator activity	1/1188	15/18367	0.633374204503318	0.882628770618387	GNAS	1
GO:0016846	carbon-sulfur lyase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	MGST3	1
GO:0017136	NAD-dependent histone deacetylase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	HDAC2	1
GO:0042809	vitamin D receptor binding	1/1188	15/18367	0.633374204503318	0.882628770618387	TAF11	1
GO:0042813	Wnt-activated receptor activity	1/1188	15/18367	0.633374204503318	0.882628770618387	LRP5	1
GO:0043138	3'-5' DNA helicase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	MCM6	1
GO:0045125	bioactive lipid receptor activity	1/1188	15/18367	0.633374204503318	0.882628770618387	S1PR4	1
GO:0047372	acylglycerol lipase activity	1/1188	15/18367	0.633374204503318	0.882628770618387	MGLL	1
GO:0048185	activin binding	1/1188	15/18367	0.633374204503318	0.882628770618387	TGFBR3	1
GO:0051371	muscle alpha-actinin binding	1/1188	15/18367	0.633374204503318	0.882628770618387	PDLIM1	1
GO:0070742	C2H2 zinc finger domain binding	1/1188	15/18367	0.633374204503318	0.882628770618387	MBD2	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/1188	15/18367	0.633374204503318	0.882628770618387	PYCARD	1
GO:0098847	sequence-specific single stranded DNA binding	1/1188	15/18367	0.633374204503318	0.882628770618387	RAD50	1
GO:1990825	sequence-specific mRNA binding	1/1188	15/18367	0.633374204503318	0.882628770618387	TYMS	1
GO:0008200	ion channel inhibitor activity	2/1188	33/18367	0.638991337485976	0.882628770618387	RASA1/ENSA	2
GO:0015171	amino acid transmembrane transporter activity	5/1188	84/18367	0.640121015008108	0.882628770618387	SLC38A1/SLC38A9/SLC1A3/SLC25A13/SLC7A7	5
GO:0030295	protein kinase activator activity	6/1188	101/18367	0.643732712340227	0.882628770618387	ERBB3/CD24/CKS2/IGF2/CKS1B/CCNB1	6
GO:0001217	DNA-binding transcription repressor activity	19/1188	313/18367	0.646821663086415	0.882628770618387	PEG3/NFE2L3/GATA3/TFAP2A/IRX2/NR2F6/TBX3/HIC2/TFAP2C/CEBPB/SKIL/SPI1/BHLHE41/ENO1/CREM/TFEC/IFI16/JUN/ZEB2	19
GO:0016229	steroid dehydrogenase activity	2/1188	34/18367	0.655252061100478	0.882628770618387	HSD17B1/HSD17B11	2
GO:0016248	channel inhibitor activity	2/1188	34/18367	0.655252061100478	0.882628770618387	RASA1/ENSA	2
GO:0015081	sodium ion transmembrane transporter activity	9/1188	152/18367	0.655934634493495	0.882628770618387	SLC6A4/SLC38A1/SLC13A4/SLC13A3/SLC9A1/SLC5A3/SLC5A6/SLC1A3/SLC8A1	9
GO:0015103	inorganic anion transmembrane transporter activity	9/1188	152/18367	0.655934634493495	0.882628770618387	SLC26A2/CLDN4/SLC6A4/SLC22A11/SLC13A4/FXYD3/CLIC3/GABRE/VDAC1	9
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/1188	16/18367	0.657107391352166	0.882628770618387	TYMS	1
GO:0003688	DNA replication origin binding	1/1188	16/18367	0.657107391352166	0.882628770618387	HSPD1	1
GO:0004698	calcium-dependent protein kinase C activity	1/1188	16/18367	0.657107391352166	0.882628770618387	PRKCZ	1
GO:0005372	water transmembrane transporter activity	1/1188	16/18367	0.657107391352166	0.882628770618387	AQP9	1
GO:0005402	carbohydrate:cation symporter activity	1/1188	16/18367	0.657107391352166	0.882628770618387	SLC5A3	1
GO:0005521	lamin binding	1/1188	16/18367	0.657107391352166	0.882628770618387	BNIP3L	1
GO:0015923	mannosidase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	MAN1A2	1
GO:0016307	phosphatidylinositol phosphate kinase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	PIK3C2A	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/1188	16/18367	0.657107391352166	0.882628770618387	IL4I1	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/1188	16/18367	0.657107391352166	0.882628770618387	APEX1	1
GO:0022821	potassium ion antiporter activity	1/1188	16/18367	0.657107391352166	0.882628770618387	SLC9A1	1
GO:0034979	NAD-dependent protein deacetylase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	HDAC2	1
GO:0035173	histone kinase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	JAK2	1
GO:0042577	lipid phosphatase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	PLPP3	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/1188	16/18367	0.657107391352166	0.882628770618387	SOCS3	1
GO:0050135	NAD(P)+ nucleosidase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	TLR2	1
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	1/1188	16/18367	0.657107391352166	0.882628770618387	TLR2	1
GO:0070403	NAD+ binding	1/1188	16/18367	0.657107391352166	0.882628770618387	HPGD	1
GO:0070492	oligosaccharide binding	1/1188	16/18367	0.657107391352166	0.882628770618387	CHID1	1
GO:0140327	flippase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	ATP10D	1
GO:1990380	Lys48-specific deubiquitinase activity	1/1188	16/18367	0.657107391352166	0.882628770618387	USP27X	1
GO:0017046	peptide hormone binding	3/1188	52/18367	0.662450590569525	0.886205007400119	SLC40A1/IGF1R/PRLR	3
GO:0031593	polyubiquitin modification-dependent protein binding	3/1188	52/18367	0.662450590569525	0.886205007400119	AGL/VCP/RAD23B	3
GO:0031490	chromatin DNA binding	6/1188	103/18367	0.662527500412282	0.886205007400119	HMGN3/HDAC2/ACTB/APEX1/MBD2/HMGN1	6
GO:0004175	endopeptidase activity	26/1188	430/18367	0.66888013024189	0.886205007400119	ADAMTS6/ADAMTS1/DPP4/CTSV/MME/CTSL/PSMB9/CTSS/PRSS8/PSMB8/CTSH/LGMN/GPAA1/HTRA1/PSMB2/PSMB1/AFG3L2/PSMB6/PSMB5/PMPCB/PYCARD/USP14/USP47/PSMB7/ADAM8/PSMB4	26
GO:0005253	anion channel activity	5/1188	87/18367	0.670737296293839	0.886205007400119	CLDN4/FXYD3/CLIC3/GABRE/VDAC1	5
GO:0000175	3'-5'-exoribonuclease activity	2/1188	35/18367	0.670921716822825	0.886205007400119	REXO2/ISG20	2
GO:0050661	NADP binding	3/1188	53/18367	0.675138186285477	0.886205007400119	HSD17B1/GAPDH/IDH1	3
GO:0016757	glycosyltransferase activity	16/1188	270/18367	0.678019759274184	0.886205007400119	TYMP/CHPF/EXTL2/AGL/QPRT/PARP1/GALNT11/RPN2/FUT8/UPP1/ST3GAL4/OSTC/C1GALT1/MGAT1/PARP9/PNP	16
GO:0000400	four-way junction DNA binding	1/1188	17/18367	0.679305441544179	0.886205007400119	HMGB3	1
GO:0004697	protein kinase C activity	1/1188	17/18367	0.679305441544179	0.886205007400119	PRKCZ	1
GO:0005005	transmembrane-ephrin receptor activity	1/1188	17/18367	0.679305441544179	0.886205007400119	EPHB4	1
GO:0005149	interleukin-1 receptor binding	1/1188	17/18367	0.679305441544179	0.886205007400119	TRIP6	1
GO:0008308	voltage-gated anion channel activity	1/1188	17/18367	0.679305441544179	0.886205007400119	VDAC1	1
GO:0008484	sulfuric ester hydrolase activity	1/1188	17/18367	0.679305441544179	0.886205007400119	SULF2	1
GO:0009881	photoreceptor activity	1/1188	17/18367	0.679305441544179	0.886205007400119	OPN3	1
GO:0015108	chloride transmembrane transporter activity	1/1188	17/18367	0.679305441544179	0.886205007400119	SLC26A2	1
GO:0015377	cation:chloride symporter activity	1/1188	17/18367	0.679305441544179	0.886205007400119	SLC6A4	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/1188	17/18367	0.679305441544179	0.886205007400119	FTH1	1
GO:0031420	alkali metal ion binding	1/1188	17/18367	0.679305441544179	0.886205007400119	PKM	1
GO:0046965	retinoid X receptor binding	1/1188	17/18367	0.679305441544179	0.886205007400119	FUS	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/1188	17/18367	0.679305441544179	0.886205007400119	C1GALT1	1
GO:0050780	dopamine receptor binding	1/1188	17/18367	0.679305441544179	0.886205007400119	GNAS	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4/1188	71/18367	0.682256521822388	0.888892961852145	HINT1/TGM2/HINT2/HDAC2	4
GO:0020037	heme binding	8/1188	139/18367	0.683732884291488	0.889655043706525	CYBA/CYBB/HEBP2/CYB5A/EIF2AK1/PGRMC2/CYCS/JAK2	8
GO:0005543	phospholipid binding	28/1188	466/18367	0.685797102644982	0.890294737344726	MME/PHLDA2/PEBP1/SYT7/FERMT2/SCIN/ANXA3/SNX10/NCF1/SLC9A1/SH3YL1/PHLDA3/PLEKHA5/APOE/PXDC1/GPAA1/APOC1/PIK3C2A/STOML2/TREM2/MYO1G/BAD/SNX6/HSPA8/IQGAP2/SNX3/VDAC1/CD300A	28
GO:0061631	ubiquitin conjugating enzyme activity	2/1188	36/18367	0.686008670358812	0.890294737344726	UBE2L6/UBE2H	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/1188	54/18367	0.687470195047639	0.891032798256551	P4HB/ASPH/P4HA1	3
GO:1901981	phosphatidylinositol phosphate binding	10/1188	173/18367	0.688512390813899	0.89122615568388	PHLDA2/SYT7/FERMT2/SCIN/SLC9A1/PHLDA3/PLEKHA5/MYO1G/IQGAP2/SNX3	10
GO:0019888	protein phosphatase regulator activity	5/1188	89/18367	0.69016863861275	0.892212825564151	PTN/LGALS3/PHACTR2/SET/ENSA	5
GO:0019208	phosphatase regulator activity	6/1188	107/18367	0.698203934121282	0.892875648071829	PTN/LGALS3/PHACTR2/SET/ZEB2/ENSA	6
GO:0004550	nucleoside diphosphate kinase activity	1/1188	18/18367	0.700067574266005	0.892875648071829	NME1	1
GO:0016755	aminoacyltransferase activity	1/1188	18/18367	0.700067574266005	0.892875648071829	TGM2	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/1188	18/18367	0.700067574266005	0.892875648071829	MARVELD3	1
GO:0045236	CXCR chemokine receptor binding	1/1188	18/18367	0.700067574266005	0.892875648071829	CXCL10	1
GO:0046624	sphingolipid transporter activity	1/1188	18/18367	0.700067574266005	0.892875648071829	ATP10D	1
GO:0050811	GABA receptor binding	1/1188	18/18367	0.700067574266005	0.892875648071829	GABARAPL1	1
GO:0099095	ligand-gated anion channel activity	1/1188	18/18367	0.700067574266005	0.892875648071829	GABRE	1
GO:0140597	protein carrier activity	1/1188	18/18367	0.700067574266005	0.892875648071829	HSPA8	1
GO:1904047	S-adenosyl-L-methionine binding	1/1188	18/18367	0.700067574266005	0.892875648071829	PRMT1	1
GO:0005109	frizzled binding	2/1188	37/18367	0.700522677795834	0.892875648071829	RNF43/ZNRF3	2
GO:0035064	methylated histone binding	4/1188	73/18367	0.703238905473565	0.894054047977857	MORC4/CBX4/CBX5/CDYL	4
GO:0140034	methylation-dependent protein binding	4/1188	73/18367	0.703238905473565	0.894054047977857	MORC4/CBX4/CBX5/CDYL	4
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	7/1188	125/18367	0.706110975782529	0.896438986030593	APOBEC3A/HINT1/TGM2/HINT2/ATIC/HDAC2/GCH1	7
GO:0005254	chloride channel activity	4/1188	74/18367	0.713347062879035	0.896438986030593	CLDN4/FXYD3/CLIC3/GABRE	4
GO:0005501	retinoid binding	2/1188	38/18367	0.714474671051443	0.896438986030593	NR2F2/OPN3	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/1188	38/18367	0.714474671051443	0.896438986030593	SLC38A1/SLC38A9	2
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	2/1188	38/18367	0.714474671051443	0.896438986030593	REXO2/ISG20	2
GO:0019213	deacetylase activity	2/1188	38/18367	0.714474671051443	0.896438986030593	HDAC2/OARD1	2
GO:0019840	isoprenoid binding	2/1188	38/18367	0.714474671051443	0.896438986030593	NR2F2/OPN3	2
GO:0140303	intramembrane lipid transporter activity	2/1188	38/18367	0.714474671051443	0.896438986030593	ATP10D/PLSCR1	2
GO:0000339	RNA cap binding	1/1188	19/18367	0.71948660101253	0.896438986030593	NCBP3	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/1188	19/18367	0.71948660101253	0.896438986030593	GALNT11	1
GO:0004890	GABA-A receptor activity	1/1188	19/18367	0.71948660101253	0.896438986030593	GABRE	1
GO:0005003	ephrin receptor activity	1/1188	19/18367	0.71948660101253	0.896438986030593	EPHB4	1
GO:0016918	retinal binding	1/1188	19/18367	0.71948660101253	0.896438986030593	OPN3	1
GO:0030627	pre-mRNA 5'-splice site binding	1/1188	19/18367	0.71948660101253	0.896438986030593	SNRPC	1
GO:0035613	RNA stem-loop binding	1/1188	19/18367	0.71948660101253	0.896438986030593	MYH10	1
GO:0052742	phosphatidylinositol kinase activity	1/1188	19/18367	0.71948660101253	0.896438986030593	PIK3C2A	1
GO:0046982	protein heterodimerization activity	19/1188	328/18367	0.724087880036794	0.899968264545616	TENM3/JAM3/ADRB1/CYBA/EPAS1/ERBB3/CYBB/P4HB/ITGB1/CEBPB/TAF11/RAN/BHLHE41/BCL2A1/PHB/YWHAE/TOP2A/SMC3/NR4A1	19
GO:0004402	histone acetyltransferase activity	2/1188	39/18367	0.727876565220739	0.899968264545616	USP22/NCOA3	2
GO:0019825	oxygen binding	2/1188	39/18367	0.727876565220739	0.899968264545616	SOD2/PARK7	2
GO:0050997	quaternary ammonium group binding	2/1188	39/18367	0.727876565220739	0.899968264545616	APOC1/VDAC1	2
GO:0061650	ubiquitin-like protein conjugating enzyme activity	2/1188	39/18367	0.727876565220739	0.899968264545616	UBE2L6/UBE2H	2
GO:0004222	metalloendopeptidase activity	6/1188	111/18367	0.73126363881579	0.899968264545616	ADAMTS6/ADAMTS1/MME/AFG3L2/PMPCB/ADAM8	6
GO:0016410	N-acyltransferase activity	5/1188	94/18367	0.735254693439144	0.899968264545616	TGM2/USP22/NMT1/NCOA3/NAA10	5
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/1188	20/18367	0.737649339076467	0.899968264545616	RUVBL1	1
GO:0001972	retinoic acid binding	1/1188	20/18367	0.737649339076467	0.899968264545616	NR2F2	1
GO:0004551	nucleotide diphosphatase activity	1/1188	20/18367	0.737649339076467	0.899968264545616	NUDT4	1
GO:0016408	C-acyltransferase activity	1/1188	20/18367	0.737649339076467	0.899968264545616	HADHB	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/1188	20/18367	0.737649339076467	0.899968264545616	AASDHPPT	1
GO:0031418	L-ascorbic acid binding	1/1188	20/18367	0.737649339076467	0.899968264545616	P4HA1	1
GO:0031681	G-protein beta-subunit binding	1/1188	20/18367	0.737649339076467	0.899968264545616	GNG12	1
GO:0050145	nucleoside monophosphate kinase activity	1/1188	20/18367	0.737649339076467	0.899968264545616	DLG1	1
GO:0061608	nuclear import signal receptor activity	1/1188	20/18367	0.737649339076467	0.899968264545616	TNPO1	1
GO:0097001	ceramide binding	1/1188	20/18367	0.737649339076467	0.899968264545616	VDAC1	1
GO:0004532	exoribonuclease activity	2/1188	40/18367	0.740741085891087	0.90263687877815	REXO2/ISG20	2
GO:0052689	carboxylic ester hydrolase activity	8/1188	147/18367	0.741901640824622	0.902948582369479	PON2/NOTUM/IARS2/MGLL/APMAP/PTRHD1/PRDX6/LIPA	8
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3/1188	59/18367	0.7438652800546	0.903135704981132	REXO2/ISG20/APEX1	3
GO:0036002	pre-mRNA binding	3/1188	59/18367	0.7438652800546	0.903135704981132	SF1/SRSF2/SNRPC	3
GO:0019842	vitamin binding	8/1188	148/18367	0.748621973469055	0.906290883730105	GLDC/FOLR1/SLC19A1/MTR/OPN3/KYNU/TYMS/P4HA1	8
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/1188	41/18367	0.753081614650557	0.906290883730105	USP22/NCOA3	2
GO:0032934	sterol binding	3/1188	60/18367	0.754114550522286	0.906290883730105	OSBPL9/TSPO/VDAC1	3
GO:0001614	purinergic nucleotide receptor activity	1/1188	21/18367	0.75463699837647	0.906290883730105	GPR34	1
GO:0004407	histone deacetylase activity	1/1188	21/18367	0.75463699837647	0.906290883730105	HDAC2	1
GO:0008373	sialyltransferase activity	1/1188	21/18367	0.75463699837647	0.906290883730105	ST3GAL4	1
GO:0015125	bile acid transmembrane transporter activity	1/1188	21/18367	0.75463699837647	0.906290883730105	SLCO2B1	1
GO:0016502	nucleotide receptor activity	1/1188	21/18367	0.75463699837647	0.906290883730105	GPR34	1
GO:0140416	transcription regulator inhibitor activity	1/1188	21/18367	0.75463699837647	0.906290883730105	ID1	1
GO:0003730	mRNA 3'-UTR binding	11/1188	201/18367	0.758429929002187	0.909751285029065	IGF2BP3/ZFP36/DHX36/FUS/RPL5/SERBP1/CARHSP1/PABPC1/RPS7/ZFP36L1/CIRBP	11
GO:0043621	protein self-association	3/1188	61/18367	0.76403093876728	0.913283244958235	SLC2A1/RSAD2/ADAM8	3
GO:0005506	iron ion binding	8/1188	151/18367	0.768043986193219	0.913283244958235	FTH1/CDO1/ADI1/FDX1/CALR/ACO2/P4HA1/ISCU	8
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/1188	22/18367	0.770525543341517	0.913283244958235	AKR1B1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/1188	22/18367	0.770525543341517	0.913283244958235	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/1188	22/18367	0.770525543341517	0.913283244958235	SLC27A2	1
GO:0016917	GABA receptor activity	1/1188	22/18367	0.770525543341517	0.913283244958235	GABRE	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/1188	22/18367	0.770525543341517	0.913283244958235	VCAN	1
GO:0030742	GTP-dependent protein binding	1/1188	22/18367	0.770525543341517	0.913283244958235	GCH1	1
GO:0033558	protein deacetylase activity	1/1188	22/18367	0.770525543341517	0.913283244958235	HDAC2	1
GO:0033691	sialic acid binding	1/1188	22/18367	0.770525543341517	0.913283244958235	FCN1	1
GO:0004180	carboxypeptidase activity	2/1188	43/18367	0.776246690309756	0.915581240661443	LAP3/CPM	2
GO:0005246	calcium channel regulator activity	2/1188	43/18367	0.776246690309756	0.915581240661443	TSPAN13/YWHAE	2
GO:0030544	Hsp70 protein binding	2/1188	43/18367	0.776246690309756	0.915581240661443	ST13/RPS3	2
GO:0030547	signaling receptor inhibitor activity	2/1188	43/18367	0.776246690309756	0.915581240661443	LRPAP1/LILRB4	2
GO:0035591	signaling adaptor activity	4/1188	81/18367	0.777051413667577	0.915581240661443	DLG5/SORBS1/MPP7/EPS8	4
GO:0005212	structural constituent of eye lens	1/1188	23/18367	0.785386031458731	0.917670458902421	VIM	1
GO:0008483	transaminase activity	1/1188	23/18367	0.785386031458731	0.917670458902421	GFPT1	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/1188	23/18367	0.785386031458731	0.917670458902421	PRKCZ	1
GO:0016493	C-C chemokine receptor activity	1/1188	23/18367	0.785386031458731	0.917670458902421	CXCR4	1
GO:0016849	phosphorus-oxygen lyase activity	1/1188	23/18367	0.785386031458731	0.917670458902421	RNASET2	1
GO:0005319	lipid transporter activity	8/1188	154/18367	0.786362521763391	0.917670458902421	SLC27A2/SLC2A1/APOE/ATP10D/PLSCR1/OSBPL9/SLCO2B1/TSPO	8
GO:0008375	acetylglucosaminyltransferase activity	2/1188	44/18367	0.787100113046566	0.917670458902421	EXTL2/MGAT1	2
GO:0022839	ion gated channel activity	2/1188	44/18367	0.787100113046566	0.917670458902421	KCNN4/CATSPER1	2
GO:0051879	Hsp90 protein binding	2/1188	44/18367	0.787100113046566	0.917670458902421	GBP1/RPS3	2
GO:0016791	phosphatase activity	15/1188	275/18367	0.78829837873106	0.917995078148889	DUSP9/CTDSPL/PTPN14/DUSP5/PLPP3/DUSP14/DUSP1/FBP1/DLG1/PGP/PTPRC/CAMK2G/PTPN6/PTPRA/PTP4A1	15
GO:0004622	lysophospholipase activity	1/1188	24/18367	0.799284929988333	0.926464994341877	MGLL	1
GO:0008171	O-methyltransferase activity	1/1188	24/18367	0.799284929988333	0.926464994341877	COMT	1
GO:0010857	calcium-dependent protein kinase activity	1/1188	24/18367	0.799284929988333	0.926464994341877	PRKCZ	1
GO:0015295	solute:proton symporter activity	1/1188	24/18367	0.799284929988333	0.926464994341877	SLC25A3	1
GO:0046873	metal ion transmembrane transporter activity	24/1188	430/18367	0.801982578046308	0.928513472030412	SLC6A4/SLC38A1/TUSC3/SLC40A1/SLC13A4/TMEM37/SLC39A10/SLC13A3/KCNN4/SLC9A1/SLC5A3/KCNG1/SLC25A37/MRS2/ATP2B1/SLC39A1/SLC5A6/ATP2B4/SLC11A1/SLC1A3/SLC39A7/TMEM165/CATSPER1/SLC8A1	24
GO:0140296	general transcription initiation factor binding	2/1188	46/18367	0.80742249450243	0.933728446713123	TAF11/RUVBL1	2
GO:0035254	glutamate receptor binding	2/1188	47/18367	0.816921230535075	0.939778059935897	GNAS/FUS	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/1188	47/18367	0.816921230535075	0.939778059935897	ADRB1/GABRE	2
GO:1990782	protein tyrosine kinase binding	5/1188	105/18367	0.817136081649899	0.939778059935897	PTPN14/HSP90AA1/ITGB1/EIF3A/TREM2	5
GO:0001637	G protein-coupled chemoattractant receptor activity	1/1188	26/18367	0.824442634815259	0.939778059935897	CXCR4	1
GO:0004950	chemokine receptor activity	1/1188	26/18367	0.824442634815259	0.939778059935897	CXCR4	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/1188	26/18367	0.824442634815259	0.939778059935897	GLUL	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/1188	26/18367	0.824442634815259	0.939778059935897	GLUL	1
GO:0042923	neuropeptide binding	1/1188	26/18367	0.824442634815259	0.939778059935897	SORL1	1
GO:0042974	retinoic acid receptor binding	1/1188	26/18367	0.824442634815259	0.939778059935897	FUS	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/1188	26/18367	0.824442634815259	0.939778059935897	SLC26A2	1
GO:0008080	N-acetyltransferase activity	3/1188	68/18367	0.82461460874785	0.939778059935897	USP22/NCOA3/NAA10	3
GO:0016782	transferase activity, transferring sulphur-containing groups	3/1188	68/18367	0.82461460874785	0.939778059935897	TSTD1/TPST2/GAL3ST4	3
GO:0070888	E-box binding	2/1188	48/18367	0.825998163715273	0.939778059935897	GATA3/BHLHE41	2
GO:0120013	lipid transfer activity	2/1188	48/18367	0.825998163715273	0.939778059935897	APOE/TSPO	2
GO:0016758	hexosyltransferase activity	10/1188	197/18367	0.826778694011741	0.939778059935897	TYMP/CHPF/EXTL2/AGL/GALNT11/RPN2/FUT8/OSTC/C1GALT1/MGAT1	10
GO:0008242	omega peptidase activity	6/1188	126/18367	0.832066402475488	0.943599964693261	USP27X/GGH/PSMD14/USP22/USP14/USP47	6
GO:0004521	endoribonuclease activity	3/1188	69/18367	0.832085515906721	0.943599964693261	RNASET2/SND1/APEX1	3
GO:0001671	ATPase activator activity	1/1188	27/18367	0.835813996782408	0.943599964693261	DNAJB4	1
GO:0004683	calmodulin-dependent protein kinase activity	1/1188	27/18367	0.835813996782408	0.943599964693261	CAMK2G	1
GO:0051959	dynein light intermediate chain binding	1/1188	27/18367	0.835813996782408	0.943599964693261	DYNLL2	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/1188	27/18367	0.835813996782408	0.943599964693261	ATP10D	1
GO:0015485	cholesterol binding	2/1188	50/18367	0.842945562190606	0.947624382070303	TSPO/VDAC1	2
GO:0030159	signaling receptor complex adaptor activity	2/1188	50/18367	0.842945562190606	0.947624382070303	DLG5/SORBS1	2
GO:0140359	ABC-type transporter activity	2/1188	50/18367	0.842945562190606	0.947624382070303	TAP1/TAPBP	2
GO:0003953	NAD+ nucleosidase activity	1/1188	28/18367	0.846449382377964	0.947624382070303	TLR2	1
GO:0004629	phospholipase C activity	1/1188	28/18367	0.846449382377964	0.947624382070303	NOTUM	1
GO:0017056	structural constituent of nuclear pore	1/1188	28/18367	0.846449382377964	0.947624382070303	NUP214	1
GO:1990756	ubiquitin ligase-substrate adaptor activity	1/1188	28/18367	0.846449382377964	0.947624382070303	PDCD6	1
GO:0000149	SNARE binding	5/1188	110/18367	0.846974898603919	0.947624382070303	SLC6A4/SYT7/STXBP2/TMED9/RAB11A	5
GO:0004033	aldo-keto reductase (NADP) activity	1/1188	29/18367	0.856396387870901	0.954953737536491	AKR1B1	1
GO:0004181	metallocarboxypeptidase activity	1/1188	29/18367	0.856396387870901	0.954953737536491	CPM	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	1/1188	29/18367	0.856396387870901	0.954953737536491	IL4I1	1
GO:0008146	sulfotransferase activity	2/1188	52/18367	0.858380873484918	0.956098338993246	TPST2/GAL3ST4	2
GO:0004843	thiol-dependent deubiquitinase	5/1188	113/18367	0.86286365450126	0.96001998572158	USP27X/PSMD14/USP22/USP14/USP47	5
GO:0016417	S-acyltransferase activity	1/1188	30/18367	0.865699533863342	0.962102599995117	GLUL	1
GO:0003774	cytoskeletal motor activity	5/1188	114/18367	0.867842548371928	0.962340959194649	MYH10/MYO7A/MYO1G/MYO1F/SMC3	5
GO:0101005	deubiquitinase activity	5/1188	114/18367	0.867842548371928	0.962340959194649	USP27X/PSMD14/USP22/USP14/USP47	5
GO:0005544	calcium-dependent phospholipid binding	2/1188	54/18367	0.872416732994021	0.966339511129893	SYT7/ANXA3	2
GO:0015085	calcium ion transmembrane transporter activity	6/1188	135/18367	0.87634694036775	0.968630452911275	TMEM37/ATP2B1/ATP2B4/TMEM165/CATSPER1/SLC8A1	6
GO:0004540	ribonuclease activity	5/1188	116/18367	0.877343448975715	0.968630452911275	RNASET2/REXO2/ISG20/SND1/APEX1	5
GO:0030170	pyridoxal phosphate binding	2/1188	55/18367	0.878943861068639	0.968630452911275	GLDC/KYNU	2
GO:0004518	nuclease activity	10/1188	210/18367	0.879028569307805	0.968630452911275	RNASET2/REXO2/PLSCR1/DDX1/ISG20/RAD50/SND1/NME1/APEX1/RPS3	10
GO:0001222	transcription corepressor binding	1/1188	32/18367	0.882538130162825	0.968630452911275	STAT1	1
GO:0008378	galactosyltransferase activity	1/1188	32/18367	0.882538130162825	0.968630452911275	C1GALT1	1
GO:0030332	cyclin binding	1/1188	32/18367	0.882538130162825	0.968630452911275	CDK6	1
GO:0048019	receptor antagonist activity	1/1188	32/18367	0.882538130162825	0.968630452911275	LRPAP1	1
GO:0030374	nuclear receptor coactivator activity	2/1188	56/18367	0.885161295646375	0.968630452911275	USP22/NCOA3	2
GO:0042054	histone methyltransferase activity	2/1188	56/18367	0.885161295646375	0.968630452911275	SMYD2/PRMT1	2
GO:0070279	vitamin B6 binding	2/1188	56/18367	0.885161295646375	0.968630452911275	GLDC/KYNU	2
GO:0004623	phospholipase A2 activity	1/1188	33/18367	0.890148967433977	0.970894720764054	PRDX6	1
GO:0005251	delayed rectifier potassium channel activity	1/1188	33/18367	0.890148967433977	0.970894720764054	KCNG1	1
GO:0019239	deaminase activity	1/1188	33/18367	0.890148967433977	0.970894720764054	APOBEC3A	1
GO:0015020	glucuronosyltransferase activity	1/1188	34/18367	0.897267055504689	0.975460262956078	CHPF	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/1188	34/18367	0.897267055504689	0.975460262956078	APEX1	1
GO:0045505	dynein intermediate chain binding	1/1188	34/18367	0.897267055504689	0.975460262956078	DYNLL2	1
GO:0005179	hormone activity	5/1188	122/18367	0.902425113494818	0.980000286472066	FBN1/INSL4/RETN/IGF2/CGA	5
GO:0000217	DNA secondary structure binding	1/1188	36/18367	0.910150431376544	0.986856848169768	HMGB3	1
GO:0042578	phosphoric ester hydrolase activity	18/1188	366/18367	0.911922215472416	0.986856848169768	DUSP9/CTDSPL/PTPN14/NOTUM/DUSP5/PLPP3/DUSP14/DUSP1/FBP1/DLG1/PGP/PTPRC/CAMK2G/PTPN6/GPCPD1/PTPRA/PTP4A1/APEX1	18
GO:0019783	ubiquitin-like protein-specific protease activity	5/1188	125/18367	0.913202679591211	0.986856848169768	USP27X/PSMD14/USP22/USP14/USP47	5
GO:0016409	palmitoyltransferase activity	1/1188	37/18367	0.915973424531563	0.986856848169768	GLUL	1
GO:0030551	cyclic nucleotide binding	1/1188	37/18367	0.915973424531563	0.986856848169768	SLC19A1	1
GO:0071855	neuropeptide receptor binding	1/1188	37/18367	0.915973424531563	0.986856848169768	GNAS	1
GO:0004674	protein serine/threonine kinase activity	19/1188	386/18367	0.916458067507789	0.986856848169768	EGFR/TGFBR3/NRK/LTBP1/AAK1/PRKCZ/CDK6/BRD4/CCND3/PRKDC/STK17A/PRKACB/LATS2/TLK1/EIF2AK1/CAMK2G/EIF2AK4/SYK/MAP3K2	19
GO:0098960	postsynaptic neurotransmitter receptor activity	2/1188	62/18367	0.916649597448271	0.986856848169768	ADRB1/GABRE	2
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/1188	38/18367	0.921419336787783	0.990922950554103	TAF11	1
GO:0016741	transferase activity, transferring one-carbon groups	10/1188	225/18367	0.922588569398652	0.99111237057035	GCSH/COMT/DNMT1/DNMT3A/MTR/ATIC/SMYD2/TYMS/RNMT/PRMT1	10
GO:0004519	endonuclease activity	5/1188	129/18367	0.92593815247289	0.993641157169832	RNASET2/RAD50/SND1/APEX1/RPS3	5
GO:0008276	protein methyltransferase activity	3/1188	88/18367	0.929806431363291	0.996720535446363	DNMT3A/SMYD2/PRMT1	3
GO:0043014	alpha-tubulin binding	1/1188	40/18367	0.931275938944838	0.997224664234923	BEX4	1
GO:0008081	phosphoric diester hydrolase activity	3/1188	89/18367	0.933094414591973	0.998100992243075	NOTUM/GPCPD1/APEX1	3
GO:0004812	aminoacyl-tRNA ligase activity	1/1188	41/18367	0.935730797052195	0.998212100686871	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/1188	41/18367	0.935730797052195	0.998212100686871	IARS2	1
GO:0004252	serine-type endopeptidase activity	7/1188	174/18367	0.938366318021739	0.998212100686871	DPP4/CTSV/CTSS/PRSS8/CTSH/HTRA1/ADAM8	7
GO:0016407	acetyltransferase activity	3/1188	91/18367	0.939248331821855	0.998212100686871	USP22/NCOA3/NAA10	3
GO:0019894	kinesin binding	1/1188	42/18367	0.939897107927563	0.998212100686871	ACTB	1
GO:0008017	microtubule binding	12/1188	271/18367	0.940022607689351	0.998212100686871	GAPDH/CAPN6/CNN3/S100A8/CLIP1/MX1/MX2/LRPPRC/DST/CENPF/RAB11A/RPS3	12
GO:0008168	methyltransferase activity	9/1188	214/18367	0.940199774194047	0.998212100686871	GCSH/COMT/DNMT1/DNMT3A/MTR/SMYD2/TYMS/RNMT/PRMT1	9
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	6/1188	156/18367	0.942964663905443	0.9988398296388	COMT/DNMT1/DNMT3A/SMYD2/RNMT/PRMT1	6
GO:0016790	thiolester hydrolase activity	1/1188	43/18367	0.943793546442273	0.9988398296388	PNKD	1
GO:0018024	histone-lysine N-methyltransferase activity	1/1188	43/18367	0.943793546442273	0.9988398296388	SMYD2	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/1188	44/18367	0.947437579777057	0.999999626384236	GABRE	1
GO:0005245	voltage-gated calcium channel activity	1/1188	45/18367	0.950845545460889	0.999999626384236	CATSPER1	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/1188	45/18367	0.950845545460889	0.999999626384236	APEX1	1
GO:0140223	general transcription initiation factor activity	1/1188	45/18367	0.950845545460889	0.999999626384236	TAF11	1
GO:0000049	tRNA binding	2/1188	72/18367	0.951800933708704	0.999999626384236	IARS2/EIF2AK4	2
GO:0008170	N-methyltransferase activity	3/1188	97/18367	0.954703299100285	0.999999626384236	SMYD2/RNMT/PRMT1	3
GO:0030695	GTPase regulator activity	23/1188	488/18367	0.959717282286423	0.999999626384236	ADRB1/HACD3/SYDE2/DOCK9/RASA1/NRP1/NET1/FAM13A/VAV3/RANBP1/EIF5/GPSM3/ARHGDIB/ARF4/WASL/DOCK10/RGS10/RABEP1/RASGEF1B/LAMTOR5/SMAP2/JUN/IQGAP2	23
GO:0060589	nucleoside-triphosphatase regulator activity	23/1188	488/18367	0.959717282286423	0.999999626384236	ADRB1/HACD3/SYDE2/DOCK9/RASA1/NRP1/NET1/FAM13A/VAV3/RANBP1/EIF5/GPSM3/ARHGDIB/ARF4/WASL/DOCK10/RGS10/RABEP1/RASGEF1B/LAMTOR5/SMAP2/JUN/IQGAP2	23
GO:0008528	G protein-coupled peptide receptor activity	5/1188	147/18367	0.964932230081752	0.999999626384236	LGR5/LGR4/CXCR4/FPR1/FPR3	5
GO:0030971	receptor tyrosine kinase binding	2/1188	78/18367	0.965537311752124	0.999999626384236	PTPN14/EIF3A	2
GO:0008227	G protein-coupled amine receptor activity	1/1188	51/18367	0.967125926172941	0.999999626384236	ADRB1	1
GO:0034987	immunoglobulin receptor binding	2/1188	79/18367	0.967425534022148	0.999999626384236	FLNA/FGR	2
GO:0008236	serine-type peptidase activity	7/1188	191/18367	0.967431198892701	0.999999626384236	DPP4/CTSV/CTSS/PRSS8/CTSH/HTRA1/ADAM8	7
GO:0140098	catalytic activity, acting on RNA	17/1188	386/18367	0.967607964237894	0.999999626384236	POLR2L/IARS2/DDX3Y/RNASET2/REXO2/DHX36/DDX27/DDX1/ISG20/PTRHD1/DHX15/RNMT/SND1/POLR2I/POLR2K/APEX1/POLR2F	17
GO:0004620	phospholipase activity	3/1188	104/18367	0.96806809814404	0.999999626384236	NOTUM/MGLL/PRDX6	3
GO:0016298	lipase activity	4/1188	129/18367	0.970803442942168	0.999999626384236	NOTUM/MGLL/PRDX6/LIPA	4
GO:0017171	serine hydrolase activity	7/1188	195/18367	0.972132499501181	0.999999626384236	DPP4/CTSV/CTSS/PRSS8/CTSH/HTRA1/ADAM8	7
GO:0001653	peptide receptor activity	5/1188	153/18367	0.972966068281408	0.999999626384236	LGR5/LGR4/CXCR4/FPR1/FPR3	5
GO:0061659	ubiquitin-like protein ligase activity	13/1188	316/18367	0.973042374810714	0.999999626384236	RNF43/ZNRF3/CBX4/SIAH1/SIAH2/UBE4B/MYLIP/ANAPC11/MDM2/TRIM22/WWP1/UFL1/RNF130	13
GO:0008374	O-acyltransferase activity	1/1188	54/18367	0.973117066970836	0.999999626384236	PRDX6	1
GO:0030594	neurotransmitter receptor activity	3/1188	111/18367	0.977644555565894	0.999999626384236	ADRB1/GABRE/TSPO	3
GO:0005548	phospholipid transporter activity	1/1188	57/18367	0.978017100803656	0.999999626384236	PLSCR1	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	8/1188	222/18367	0.978076064475889	0.999999626384236	TGM2/USP22/NMT1/NCOA3/PRDX6/HADHB/NAA10/GLUL	8
GO:0005085	guanyl-nucleotide exchange factor activity	8/1188	223/18367	0.978901156099766	0.999999626384236	ADRB1/DOCK9/NET1/VAV3/ARF4/DOCK10/RASGEF1B/LAMTOR5	8
GO:0016279	protein-lysine N-methyltransferase activity	1/1188	59/18367	0.980777245501226	0.999999626384236	SMYD2	1
GO:0005096	GTPase activator activity	20/1188	462/18367	0.981426253528103	0.999999626384236	ADRB1/HACD3/SYDE2/DOCK9/RASA1/NRP1/NET1/FAM13A/VAV3/RANBP1/ARHGDIB/ARF4/DOCK10/RGS10/RABEP1/RASGEF1B/LAMTOR5/SMAP2/JUN/IQGAP2	20
GO:0043178	alcohol binding	2/1188	89/18367	0.981571215411691	0.999999626384236	TSPO/VDAC1	2
GO:0016278	lysine N-methyltransferase activity	1/1188	60/18367	0.982024603614868	0.999999626384236	SMYD2	1
GO:0022824	transmitter-gated ion channel activity	1/1188	60/18367	0.982024603614868	0.999999626384236	GABRE	1
GO:0022835	transmitter-gated channel activity	1/1188	60/18367	0.982024603614868	0.999999626384236	GABRE	1
GO:0008194	UDP-glycosyltransferase activity	4/1188	143/18367	0.984995892407619	0.999999626384236	CHPF/EXTL2/GALNT11/MGAT1	4
GO:0008173	RNA methyltransferase activity	1/1188	65/18367	0.987148078555067	0.999999626384236	RNMT	1
GO:0106310	protein serine kinase activity	14/1188	360/18367	0.987819754233609	0.999999626384236	NRK/AAK1/PRKCZ/CDK6/PRKDC/STK17A/PRKACB/LATS2/TLK1/EIF2AK1/CAMK2G/EIF2AK4/STK26/MAP3K2	14
GO:0061630	ubiquitin protein ligase activity	11/1188	304/18367	0.989616516022558	0.999999626384236	RNF43/ZNRF3/SIAH1/SIAH2/UBE4B/MYLIP/ANAPC11/MDM2/TRIM22/WWP1/RNF130	11
GO:0003777	microtubule motor activity	1/1188	69/18367	0.99017415103353	0.999999626384236	SMC3	1
GO:0005244	voltage-gated ion channel activity	6/1188	201/18367	0.991285355334169	0.999999626384236	TMEM37/CLIC3/CYBB/KCNG1/CATSPER1/VDAC1	6
GO:0022832	voltage-gated channel activity	6/1188	201/18367	0.991285355334169	0.999999626384236	TMEM37/CLIC3/CYBB/KCNG1/CATSPER1/VDAC1	6
GO:0005230	extracellular ligand-gated ion channel activity	1/1188	73/18367	0.992488170181926	0.999999626384236	GABRE	1
GO:0016746	acyltransferase activity	8/1188	250/18367	0.992818299562013	0.999999626384236	TGM2/USP22/NMT1/NCOA3/PRDX6/HADHB/NAA10/GLUL	8
GO:0019787	ubiquitin-like protein transferase activity	18/1188	458/18367	0.993440132186998	0.999999626384236	RNF43/ZNRF3/KLHL42/CBX4/SIAH1/LMO7/SIAH2/UBE2L6/UBE4B/MYLIP/UBE2H/ANAPC11/MDM2/RNF213/TRIM22/WWP1/UFL1/RNF130	18
GO:0004842	ubiquitin-protein transferase activity	16/1188	433/18367	0.996006205975601	0.999999626384236	RNF43/ZNRF3/KLHL42/SIAH1/LMO7/SIAH2/UBE2L6/UBE4B/MYLIP/UBE2H/ANAPC11/MDM2/RNF213/TRIM22/WWP1/RNF130	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	4/1188	170/18367	0.996098938853694	0.999999626384236	P4HB/DEGS1/ASPH/P4HA1	4
GO:0005262	calcium channel activity	2/1188	119/18367	0.996834020976462	0.999999626384236	TMEM37/CATSPER1	2
GO:0005267	potassium channel activity	2/1188	121/18367	0.997191049392982	0.999999626384236	KCNN4/KCNG1	2
GO:0005249	voltage-gated potassium channel activity	1/1188	90/18367	0.997602283363805	0.999999626384236	KCNG1	1
GO:0140101	catalytic activity, acting on a tRNA	2/1188	124/18367	0.997653561637486	0.999999626384236	IARS2/PTRHD1	2
GO:0015079	potassium ion transmembrane transporter activity	3/1188	155/18367	0.997894019641894	0.999999626384236	KCNN4/SLC9A1/KCNG1	3
GO:0022836	gated channel activity	10/1188	340/18367	0.998936843921801	0.999999626384236	TMEM37/CLIC3/GABRE/TMEM150C/TMC5/CYBB/KCNN4/KCNG1/CATSPER1/VDAC1	10
GO:0022843	voltage-gated cation channel activity	2/1188	143/18367	0.999257315902385	0.999999626384236	KCNG1/CATSPER1	2
GO:0015267	channel activity	15/1188	480/18367	0.999681474358086	0.999999626384236	GJA5/CLDN4/GJA1/FXYD3/TMEM37/CLIC3/GABRE/TMEM150C/TMC5/CYBB/KCNN4/KCNG1/CATSPER1/VDAC1/AQP9	15
GO:0022803	passive transmembrane transporter activity	15/1188	481/18367	0.999693885762197	0.999999626384236	GJA5/CLDN4/GJA1/FXYD3/TMEM37/CLIC3/GABRE/TMEM150C/TMC5/CYBB/KCNN4/KCNG1/CATSPER1/VDAC1/AQP9	15
GO:0015276	ligand-gated ion channel activity	1/1188	143/18367	0.999932307718389	0.999999626384236	GABRE	1
GO:0022834	ligand-gated channel activity	1/1188	143/18367	0.999932307718389	0.999999626384236	GABRE	1
GO:0005216	ion channel activity	11/1188	432/18367	0.999948932476436	0.999999626384236	CLDN4/FXYD3/TMEM37/CLIC3/GABRE/TMEM150C/TMC5/KCNN4/KCNG1/CATSPER1/VDAC1	11
GO:0005261	cation channel activity	4/1188	335/18367	0.999999626384236	0.999999626384236	TMEM37/KCNN4/KCNG1/CATSPER1	4