ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0048002 antigen processing and presentation of peptide antigen 27/1165 62/18722 6.93900302913659e-17 3.89486240025437e-13 HLA-B/HLA-A/CTSV/HLA-C/CTSL/B2M/CTSS/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/HLA-F/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/PYCARD/SLC11A1/TREM2/TAP1/CALR/HLA-DMA/HLA-DQA1/TAPBP/HLA-DQA2/HLA-DMB 27 GO:0045785 positive regulation of cell adhesion 76/1165 437/18722 2.15632144750859e-16 6.05171614243287e-13 ADGRG1/CCDC80/HLA-A/DPP4/BMP7/ITGA6/DAG1/FERMT1/B2M/GATA3/CD44/PRKCZ/ANK3/HSPD1/CDK6/TFRC/GLI3/HLA-E/TJP1/CD24/FERMT2/HLA-DPA1/PLPP3/S100A10/NRP1/AIF1/HLA-DRA/P4HB/YES1/PTN/HLA-DRB1/HLA-DPB1/RHOA/TGM2/VEGFA/PTPRC/IL4I1/SOX4/VAV3/C1QBP/FLNA/CD55/PLAUR/CD86/CD46/IL6ST/CD74/CIB1/PYCARD/PTPN6/TNFSF13B/ST3GAL4/LILRB2/LIMS1/LILRB4/TRIOBP/JAK1/CALR/IGF2/HLA-DMA/BAD/APBB1IP/RRAS/HLA-DQA1/LILRB1/NFAT5/UTRN/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/JAK2/HLA-DMB/LYN 76 GO:0022900 electron transport chain 44/1165 175/18722 7.13563531994727e-16 1.33507736836213e-12 GLDC/COX6C/CYBA/UQCRQ/CYBB/NCF2/ADH5/NCF1/AKR1B1/DEGS1/ALDH2/CYB5A/ASPH/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/ETFA/NDUFC2/DLD/PARK7/FDX1/NDUFB10/NDUFS6/SLC25A13/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/SCO2/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 44 GO:0019882 antigen processing and presentation 33/1165 106/18722 3.66989999160255e-15 5.14978716321628e-12 HLA-B/HLA-A/CTSV/HLA-C/CTSL/B2M/CTSS/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/PSMB8/FGL2/CTSH/HLA-F/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/PYCARD/SLC11A1/CD68/TREM2/LILRB2/TAP1/CALR/HLA-DMA/HLA-DQA1/PSME1/TAPBP/HLA-DQA2/HLA-DMB 33 GO:0002478 antigen processing and presentation of exogenous peptide antigen 20/1165 38/18722 7.40382794866017e-15 8.31153725516590e-12 HLA-A/CTSV/CTSL/B2M/CTSS/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/HLA-F/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/TAP1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 20 GO:0022407 regulation of cell-cell adhesion 73/1165 448/18722 2.8400088133131e-14 2.65682824485441e-11 TENM3/CDH1/HLA-A/DPP4/BMP7/DLG5/B2M/SPINT2/GATA3/CD44/PRKCZ/ANK3/HSPD1/TFRC/GLI3/PAWR/LAPTM5/ASS1/HLA-E/TJP1/CD24/HLA-DPA1/PLPP3/AIF1/PRDX2/HLA-DRA/FGL2/YES1/CEBPB/DLG1/FXYD5/HLA-DRB1/HLA-DPB1/RHOA/VEGFA/PTPRC/IL4I1/SOX4/CD55/LGALS3/PLAUR/SPI1/CD9/CD86/IRF1/CD46/KLF4/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/TGFB1/ST3GAL4/LILRB2/LILRB4/JAK1/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/NFAT5/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/CD300A/JAK2/HLA-DMB/LYN 73 GO:0007159 leukocyte cell-cell adhesion 64/1165 371/18722 7.94765186432587e-14 6.37288141635159e-11 HLA-A/DPP4/BMP7/DLG5/B2M/GATA3/CD44/PRKCZ/HSPD1/TFRC/GLI3/PAWR/LAPTM5/ASS1/HLA-E/CD24/HLA-DPA1/OLR1/AIF1/PRDX2/HLA-DRA/FGL2/YES1/ITGB1/CEBPB/DLG1/S100A8/PECAM1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/LGALS3/CD86/IRF1/CD46/KLF4/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/MSN/ST3GAL4/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/NFAT5/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/CD300A/HLA-DMB/LYN 64 GO:0019884 antigen processing and presentation of exogenous antigen 21/1165 47/18722 1.04621095566869e-13 7.30945525803703e-11 HLA-A/CTSV/CTSL/B2M/CTSS/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/HLA-F/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/TAP1/HLA-DMA/HLA-DQA1/PSME1/HLA-DQA2/HLA-DMB 21 GO:0006091 generation of precursor metabolites and energy 76/1165 490/18722 1.17201313597601e-13 7.30945525803703e-11 GLDC/ACSS1/LDHA/PHLDA2/SORBS1/APP/ALDOA/AGL/COX6C/CYBA/UQCRQ/CYBB/GAPDH/RPIA/NCF2/ADH5/NCF1/FBP1/IDH1/AKR1B1/DEGS1/TPI1/ALDH2/VCP/CYB5A/GFPT1/RHOA/ASPH/UQCR10/COX7C/CISD1/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/IL6ST/ETFA/NDUFC2/PGK1/DLD/STOML2/OPN3/PKM/SUCLG1/PARK7/MDH1/UQCC2/FDX1/ENO1/NDUFB10/NDUFS6/SLC25A13/NDUFB2/IGF2/NDUFB9/NDUFA10/PHKB/ACO2/COX7A2/NDUFB1/ISCU/UGP2/CYCS/BNIP3/NDUFA5/NDUFS3/NDUFS8/SCO2/IL10RB/NDUFV2/NDUFA4/ACADVL/CCNB1/UQCR11/COX6A1 76 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 18/1165 34/18722 1.46374248317118e-13 8.21598655803985e-11 CTSV/CTSL/B2M/CTSS/FCER1G/HLA-DPA1/HLA-DRA/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/PYCARD/TREM2/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 18 GO:0046034 ATP metabolic process 53/1165 277/18722 1.66579846144124e-13 8.24720623794859e-11 LDHA/APP/ALDOA/ATP6V1B1/TMSB4X/COX6C/PARP1/UQCRQ/GAPDH/FBP1/TPI1/VCP/RHOA/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/PGK1/DLD/TGFB1/STOML2/PKM/TREM2/PARK7/UQCC2/ENO1/NDUFB10/NDUFS6/SLC25A13/NDUFB2/NDUFB9/NDUFA10/BAD/COX7A2/NDUFB1/NUDT5/FIS1/ISCU/TSPO/CYCS/NDUFA5/HSPA8/NDUFS3/NDUFS8/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 53 GO:0019646 aerobic electron transport chain 28/1165 87/18722 1.76316541698527e-13 8.24720623794859e-11 COX6C/UQCRQ/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/PARK7/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/UQCR11/COX6A1 28 GO:0042773 ATP synthesis coupled electron transport 29/1165 95/18722 3.0186678051391e-13 1.21027017073184e-10 COX6C/UQCRQ/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/PARK7/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 29 GO:0042775 mitochondrial ATP synthesis coupled electron transport 29/1165 95/18722 3.0186678051391e-13 1.21027017073184e-10 COX6C/UQCRQ/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/PARK7/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 29 GO:0022409 positive regulation of cell-cell adhesion 53/1165 284/18722 4.70876407068549e-13 1.76201951525051e-10 HLA-A/DPP4/BMP7/B2M/GATA3/CD44/PRKCZ/ANK3/HSPD1/TFRC/GLI3/HLA-E/TJP1/CD24/HLA-DPA1/PLPP3/AIF1/HLA-DRA/YES1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/PLAUR/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/ST3GAL4/LILRB2/LILRB4/JAK1/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/NFAT5/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/JAK2/HLA-DMB/LYN 53 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 18/1165 36/18722 5.3486065435963e-13 1.87635803307538e-10 CTSV/CTSL/B2M/CTSS/FCER1G/HLA-DPA1/HLA-DRA/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/PYCARD/TREM2/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 18 GO:0052547 regulation of peptidase activity 71/1165 461/18722 1.09363905447088e-12 3.61093883102651e-10 ITIH5/CRIM1/FBLN1/CLDN4/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/PSMB9/SERPINF1/APP/TIMP1/CD44/PCOLCE2/HSPD1/PERP/LAPTM5/GPC3/DHCR24/HSPE1/GAPDH/EFNA1/PSMB8/CTSH/PSMD14/PRDX5/PSME2/PMAIP1/GPX1/LGMN/VCP/S100A8/SIAH2/RHOA/VEGFA/ASPH/IFI6/PLAUR/CST3/A2M/PSMA3/KLF4/TNFSF10/APLP2/PYCARD/ARL6IP5/MDM2/PRDX3/USP14/PARK7/USP47/BAD/IFI16/PSME1/FIS1/BST2/LAMTOR5/CST6/CYCS/RPS3/PDCD6/SYK/LRP1/SORL1/JAK2/TFPI2/GRN/LYN/NR4A1 71 GO:1903037 regulation of leukocyte cell-cell adhesion 58/1165 336/18722 1.15842414236131e-12 3.61235261726336e-10 HLA-A/DPP4/DLG5/B2M/GATA3/CD44/PRKCZ/HSPD1/TFRC/GLI3/PAWR/LAPTM5/ASS1/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/HLA-DRA/FGL2/YES1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/LGALS3/CD86/IRF1/CD46/KLF4/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/ST3GAL4/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/NFAT5/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/CD300A/HLA-DMB/LYN 58 GO:0022904 respiratory electron transport chain 31/1165 114/18722 1.45033776456693e-12 4.28460309079693e-10 COX6C/UQCRQ/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/PARK7/NDUFB10/NDUFS6/SLC25A13/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/SCO2/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 31 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 16/1165 30/18722 2.90002823247569e-12 8.13892923444303e-10 CTSV/CTSL/B2M/CTSS/FCER1G/HLA-DPA1/HLA-DRA/LGMN/HLA-DRB1/HLA-DPB1/IFI30/CD74/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 16 GO:1903039 positive regulation of leukocyte cell-cell adhesion 46/1165 239/18722 5.42214171511141e-12 1.4214581432775e-09 HLA-A/DPP4/B2M/GATA3/CD44/PRKCZ/HSPD1/TFRC/GLI3/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DRA/YES1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/ST3GAL4/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/NFAT5/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/HLA-DMB/LYN 46 GO:0042110 T cell activation 72/1165 487/18722 5.61841104032091e-12 1.4214581432775e-09 HLA-A/DPP4/CTSL/DLG5/B2M/GATA3/CD44/PRKCZ/HSPD1/TFRC/GLI3/SOD1/PAWR/LAPTM5/HLA-E/CD24/FCER1G/HLA-DPA1/DDOST/AIF1/PRDX2/HLA-DRA/FGL2/CCND3/YES1/LCP1/CEBPB/DLG1/HLA-DRB1/PRKDC/HLA-DPB1/RHOA/CD48/PTPRC/IL4I1/SOX4/CD55/LGALS3/SPI1/CD86/IRF1/EIF2AK4/CD46/IL6ST/CD74/PYCARD/SLC11A1/PTPN6/TNFSF13B/MSN/STOML2/LILRB2/LILRB4/RSAD2/IGF2/HLA-DMA/BAD/APBB1IP/HLA-DQA1/KDELR1/LILRB1/ZFP36L1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/CD300A/HLA-DMB/TNFRSF1B/LYN 72 GO:0001819 positive regulation of cytokine production 70/1165 467/18722 5.82461024325363e-12 1.4214581432775e-09 HLA-A/FERMT1/ISL1/B2M/TYROBP/CADM1/APP/GATA3/ISG15/PRKCZ/HSPD1/SOD1/CYBA/LAPTM5/HLA-E/FCN1/CYBB/FCER1G/GAPDH/HLA-DPA1/HILPDA/AIF1/HSP90AA1/STAT1/HLA-F/CEBPB/CD14/S100A13/HLA-DPB1/PTPRC/CD55/DHX36/CD86/IRF1/DDX1/CD46/IL6ST/CD74/PYCARD/SLC11A1/GBP5/TGFB1/STOML2/TREM2/LILRB2/PARK7/GPSM3/IRF7/OAS1/RSAD2/HRAS/HDAC2/OAS2/PHB/MNDA/FGR/TLR2/LILRB1/IFI16/LAMTOR5/SULF2/RPS3/SYK/ADAM8/LRP1/PNP/CD83/SORL1/JAK2/LILRA2 70 GO:0050870 positive regulation of T cell activation 43/1165 216/18722 8.36818597048703e-12 1.95710949384766e-09 HLA-A/DPP4/B2M/GATA3/PRKCZ/HSPD1/TFRC/GLI3/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DRA/YES1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/HLA-DMB/LYN 43 GO:0016032 viral process 64/1165 415/18722 1.38136738040253e-11 3.10144604247975e-09 EGFR/DPP4/DAG1/IFITM3/CTSL/HACD3/CXCR4/ISG15/SLC52A1/TFRC/RPSA/HSP90AB1/FCN1/ITGB5/DDB1/APOBEC3A/NRP1/P4HB/APOE/ITGB1/BSG/ZFP36/STAT1/FUT8/VCP/HLA-DRB1/PPIB/PSMC3/IFITM2/CD55/MX1/TAF11/CD86/PLSCR1/EIF2AK4/CD46/RAN/CD74/ISG20/NUCKS1/EIF3A/ST3GAL4/TRIM22/WWP1/IRF7/PABPC1/OAS1/RSAD2/OAS2/PHB/PPIA/OASL/IFIT1/CCL4/IFI16/ANPEP/BST2/LAMTOR5/HSPA8/JUN/MGAT1/SNX3/PARP9/TOP2A 64 GO:0050863 regulation of T cell activation 55/1165 329/18722 1.64252590023858e-11 3.54596072232275e-09 HLA-A/DPP4/DLG5/B2M/GATA3/PRKCZ/HSPD1/TFRC/GLI3/SOD1/PAWR/LAPTM5/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/HLA-DRA/FGL2/YES1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/CD300A/HLA-DMB/TNFRSF1B/LYN 55 GO:0002181 cytoplasmic translation 34/1165 148/18722 2.13977288216238e-11 4.44835006947312e-09 RPS29/RPL37A/RPS17/RPS21/RPSA/RPS18/RPL23/RPS27/RPL31/RPLP0/RPL36/RPL27A/RPS23/RPS12/RPS28/DHX36/RPS5/RPLP2/TMA7/RPS14/RPL35/RPL5/EIF3A/RPL37/PKM/EIF2S2/EIF5/RPS27A/RPL18/RPS7/EIF3J/RPS16/RPS3/RPL10A 34 GO:0006119 oxidative phosphorylation 33/1165 141/18722 2.46616264143937e-11 4.94377532371399e-09 COX6C/UQCRQ/VCP/RHOA/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/STOML2/PARK7/UQCC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/COX7A2/NDUFB1/ISCU/CYCS/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 33 GO:0052548 regulation of endopeptidase activity 65/1165 432/18722 2.86155982607703e-11 5.53859838061048e-09 ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/PSMB9/SERPINF1/APP/TIMP1/CD44/HSPD1/PERP/LAPTM5/DHCR24/HSPE1/GAPDH/EFNA1/PSMB8/CTSH/PSMD14/PRDX5/PSME2/PMAIP1/GPX1/LGMN/VCP/S100A8/SIAH2/RHOA/VEGFA/ASPH/IFI6/PLAUR/CST3/A2M/PSMA3/KLF4/TNFSF10/APLP2/PYCARD/ARL6IP5/MDM2/PRDX3/USP14/PARK7/USP47/BAD/IFI16/PSME1/FIS1/BST2/LAMTOR5/CST6/CYCS/RPS3/PDCD6/SYK/SORL1/JAK2/TFPI2/LYN/NR4A1 65 GO:0045333 cellular respiration 43/1165 230/18722 7.1432996413982e-11 1.3365113629056e-08 COX6C/UQCRQ/IDH1/VCP/RHOA/UQCR10/COX7C/CISD1/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/STOML2/OPN3/SUCLG1/PARK7/MDH1/UQCC2/NDUFB10/NDUFS6/SLC25A13/NDUFB2/NDUFB9/NDUFA10/ACO2/COX7A2/NDUFB1/ISCU/CYCS/BNIP3/NDUFA5/NDUFS3/NDUFS8/SCO2/IL10RB/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 43 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 19/1165 51/18722 7.56484253924314e-11 1.36972455396038e-08 NDUFB7/NDUFS5/NDUFAB1/NDUFA6/NDUFC2/DLD/PARK7/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/NDUFB1/ISCU/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4 19 GO:0009060 aerobic respiration 38/1165 189/18722 1.00465903598262e-10 1.76223474030327e-08 COX6C/UQCRQ/IDH1/VCP/RHOA/UQCR10/COX7C/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/NDUFC2/DLD/STOML2/SUCLG1/PARK7/MDH1/UQCC2/NDUFB10/NDUFS6/NDUFB2/NDUFB9/NDUFA10/ACO2/COX7A2/NDUFB1/ISCU/CYCS/BNIP3/NDUFA5/NDUFS3/NDUFS8/NDUFV2/NDUFA4/CCNB1/UQCR11/COX6A1 38 GO:0006979 response to oxidative stress 65/1165 446/18722 1.15268264371606e-10 1.96060838762977e-08 EGFR/MET/BMP7/PAGE4/SOD3/LDHA/GPX8/SOD2/PON2/APP/HSPD1/PRDX4/PARP1/SOD1/PAWR/EPAS1/DHCR24/PDLIM1/KLF2/AIF1/NCF1/NET1/PRDX2/RBPMS/P4HB/DUSP1/APOE/PRDX1/GCLM/IDH1/STAT1/SESN1/PRDX5/GPX1/FUT8/FOS/ETV5/GSTP1/PSMB5/NDUFA6/KLF4/STK26/ARL6IP5/GPX4/MDM2/TXNIP/PRDX3/TREM2/PARK7/PRDX6/HDAC2/ERO1A/TXN2/BAD/PPIA/ROMO1/GCH1/APEX1/BNIP3/GPX3/SLC8A1/NDUFS8/JUN/RPS3/JAK2 65 GO:0015980 energy derivation by oxidation of organic compounds 52/1165 318/18722 1.35493535612944e-10 2.23023977709822e-08 PHLDA2/SORBS1/AGL/COX6C/UQCRQ/IDH1/VCP/GFPT1/RHOA/UQCR10/COX7C/CISD1/NDUFB7/NDUFS5/COX4I1/NDUFAB1/NDUFA6/IL6ST/NDUFC2/DLD/STOML2/OPN3/SUCLG1/PARK7/MDH1/UQCC2/NDUFB10/NDUFS6/SLC25A13/NDUFB2/IGF2/NDUFB9/NDUFA10/PHKB/ACO2/COX7A2/NDUFB1/ISCU/UGP2/CYCS/BNIP3/NDUFA5/NDUFS3/NDUFS8/SCO2/IL10RB/NDUFV2/NDUFA4/ACADVL/CCNB1/UQCR11/COX6A1 52 GO:1903706 regulation of hemopoiesis 57/1165 367/18722 1.39067151609545e-10 2.23023977709822e-08 FBN1/HLA-B/B2M/TYROBP/GATA3/ISG15/PRKCZ/CDK6/GLI3/SOD1/SCIN/PRDX2/HLA-DRA/NFKBIA/FGL2/PTN/ZFP36/STAT1/CEBPB/C1QC/FOS/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/PITHD1/EVI2B/FAM210B/SPI1/CD86/IRF1/CD46/ESRRA/CD74/CIB1/PTPN6/TGFB1/TREM2/LILRB2/LILRB4/IRF7/TMEM176B/CSF3R/BAD/LILRB1/NME1/ZFP36L1/LILRB3/PRMT1/JUN/SYK/ADAM8/PNP/CD83/LYN 57 GO:0046651 lymphocyte proliferation 48/1165 288/18722 3.59279970430529e-10 5.60177353896267e-08 HLA-A/DLG5/TYROBP/HSPD1/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/HELLS/CCND3/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/SLC11A1/PTPN6/TNFSF13B/MSN/LILRB2/LILRB4/IGF2/MNDA/LILRB1/GAPT/IMPDH2/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 48 GO:0019058 viral life cycle 51/1165 317/18722 3.69469938397754e-10 5.60495882223403e-08 EGFR/DPP4/DAG1/IFITM3/CTSL/HACD3/CXCR4/ISG15/SLC52A1/TFRC/RPSA/HSP90AB1/FCN1/ITGB5/DDB1/APOBEC3A/NRP1/P4HB/APOE/ITGB1/BSG/VCP/HLA-DRB1/PPIB/IFITM2/CD55/MX1/CD86/PLSCR1/EIF2AK4/CD46/CD74/ISG20/NUCKS1/TRIM22/WWP1/PABPC1/OAS1/RSAD2/OAS2/PHB/PPIA/OASL/IFIT1/IFI16/ANPEP/BST2/LAMTOR5/HSPA8/SNX3/TOP2A 51 GO:0009615 response to virus 56/1165 367/18722 4.00785671885046e-10 5.92002625339674e-08 IFITM3/CXCR4/GATA3/ISG15/CDK6/APOBEC3A/IFNGR2/ITGB8/BNIP3L/FGL2/AP1S1/HSP90AA1/STAT1/PMAIP1/GBP1/SKP2/HTRA1/IFIT3/PTPRC/IFI6/NCBP3/C1QBP/IFITM2/MX1/IFIT2/IFI44L/DHX36/MX2/PLSCR1/IRF1/EIF2AK4/DDX1/PYCARD/ISG20/ENO1/TRIM22/IRF7/OAS1/RSAD2/STMN1/OAS2/PHB/OASL/IFIT1/FGR/TLR2/LILRB1/CXCL10/CCL4/IFI16/BST2/LAMTOR5/BNIP3/PARP9/IL10RB/IFI44 56 GO:0070661 leukocyte proliferation 51/1165 318/18722 4.14162060278001e-10 5.96074780600107e-08 HLA-A/DLG5/TYROBP/HSPD1/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/HELLS/CCND3/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/GSTP1/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/SLC11A1/PTPN6/TNFSF13B/MSN/TREM2/LILRB2/LILRB4/IGF2/MNDA/LILRB1/BST2/GAPT/IMPDH2/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 51 GO:0032943 mononuclear cell proliferation 48/1165 291/18722 5.15479739637053e-10 7.23346944645694e-08 HLA-A/DLG5/TYROBP/HSPD1/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/HELLS/CCND3/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/SLC11A1/PTPN6/TNFSF13B/MSN/LILRB2/LILRB4/IGF2/MNDA/LILRB1/GAPT/IMPDH2/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 48 GO:0030099 myeloid cell differentiation 57/1165 381/18722 6.00920149640709e-10 8.22674341447146e-08 FBN1/TGFBR3/B2M/TYROBP/APP/GATA3/ISG15/PARP1/CDK6/TFRC/EPAS1/GPC3/SCIN/KLF2/SNX10/ITGB8/NFKBIA/PIR/ZFP36/STAT1/CEBPB/C1QC/FOS/HLA-DRB1/PRKDC/VEGFA/SLC25A5/PITHD1/EVI2B/EIF2AK1/FAM210B/SPI1/ESRRA/CD74/RPS14/JUNB/CIB1/WASF2/PTPN6/TGFB1/PRDX3/TREM2/LILRB4/IRF7/OSCAR/CSF3R/UFL1/TLR2/LILRB1/NME1/IFI16/ZFP36L1/LILRB3/PRMT1/JUN/JAK2/LYN 57 GO:0051607 defense response to virus 45/1165 265/18722 6.88979557992617e-10 8.99358664886641e-08 IFITM3/ISG15/APOBEC3A/IFNGR2/BNIP3L/FGL2/HSP90AA1/STAT1/PMAIP1/GBP1/SKP2/HTRA1/IFIT3/PTPRC/IFI6/NCBP3/C1QBP/IFITM2/MX1/IFIT2/IFI44L/DHX36/MX2/PLSCR1/IRF1/EIF2AK4/DDX1/PYCARD/ISG20/TRIM22/IRF7/OAS1/RSAD2/OAS2/PHB/OASL/IFIT1/TLR2/LILRB1/CXCL10/IFI16/BST2/BNIP3/PARP9/IL10RB 45 GO:0140546 defense response to symbiont 45/1165 265/18722 6.88979557992617e-10 8.99358664886641e-08 IFITM3/ISG15/APOBEC3A/IFNGR2/BNIP3L/FGL2/HSP90AA1/STAT1/PMAIP1/GBP1/SKP2/HTRA1/IFIT3/PTPRC/IFI6/NCBP3/C1QBP/IFITM2/MX1/IFIT2/IFI44L/DHX36/MX2/PLSCR1/IRF1/EIF2AK4/DDX1/PYCARD/ISG20/TRIM22/IRF7/OAS1/RSAD2/OAS2/PHB/OASL/IFIT1/TLR2/LILRB1/CXCL10/IFI16/BST2/BNIP3/PARP9/IL10RB 45 GO:0050670 regulation of lymphocyte proliferation 40/1165 225/18722 1.54424419868042e-09 1.96996424708937e-07 HLA-A/DLG5/TYROBP/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/MNDA/LILRB1/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 40 GO:0002683 negative regulation of immune system process 61/1165 434/18722 1.84688237505152e-09 2.30367794914759e-07 FBN1/HLA-B/HLA-A/DPP4/DLG5/TYROBP/ISG15/CDK6/GLI3/PAWR/LAPTM5/HLA-E/CD59/PRDX2/FGL2/DUSP1/YES1/HLA-F/CEBPB/DLG1/GPX1/GBP1/C1QC/HLA-DRB1/PRKDC/HTRA1/LST1/PTPRC/IL4I1/C1QBP/CD55/LGALS3/SPI1/CD86/A2M/IRF1/CD46/CD74/PTPN6/TGFB1/CD68/TREM2/LILRB2/LILRB4/TMEM176B/OAS1/HCK/TSC22D3/MNDA/WASL/FGR/LILRB1/NME1/IFI16/BST2/LILRB3/SYK/CD300A/PSMB4/GRN/LYN 61 GO:0070663 regulation of leukocyte proliferation 42/1165 245/18722 1.89681445932035e-09 2.31452599134025e-07 HLA-A/DLG5/TYROBP/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/GSTP1/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/MNDA/LILRB1/BST2/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 42 GO:0032944 regulation of mononuclear cell proliferation 40/1165 227/18722 2.01787772508501e-09 2.40986120657492e-07 HLA-A/DLG5/TYROBP/SLC39A10/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/LST1/PTPRC/IL4I1/VAV3/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/MNDA/LILRB1/RPS3/SYK/PNP/CD300A/HLA-DMB/TNFRSF1B/LYN 40 GO:0002396 MHC protein complex assembly 11/1165 19/18722 2.45991127148811e-09 2.87655874309641e-07 B2M/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DPB1/CALR/HLA-DMA/HLA-DQA1/TAPBP/HLA-DQA2/HLA-DMB 11 GO:0072593 reactive oxygen species metabolic process 41/1165 239/18722 2.89028023470353e-09 3.31084550150835e-07 EGFR/BMP7/PAGE4/SOD3/TYROBP/SOD2/TFAP2A/HSPD1/PRDX4/SOD1/CYBA/CYBB/NCF2/NCF1/PRDX2/SLC5A3/PRDX1/SESN1/PRDX5/PMAIP1/GPX1/RHOA/STK17A/IFI6/GSTP1/DCXR/GRB2/TGFB1/PRDX3/PARK7/PRDX6/ARF4/GNAI2/ROMO1/GCH1/TSPO/BNIP3/GPX3/NDUFS3/VDAC1/SYK 41 GO:0044403 biological process involved in symbiotic interaction 46/1165 290/18722 4.27201153105434e-09 4.79576014476161e-07 EGFR/DPP4/DAG1/IFITM3/CTSL/CXCR4/HSPD1/SLC52A1/TFRC/RPSA/HSP90AB1/FCN1/ITGB5/DDB1/GAPDH/NRP1/P4HB/APOE/ITGB1/BSG/GPX1/HLA-DRB1/PPIB/PSMC3/IFITM2/CD55/TAF11/CD86/PLSCR1/TREM1/EIF2AK4/CD46/CD74/NUCKS1/TRIM22/WWP1/PHB/PPIA/IFIT1/FUCA2/ROMO1/CCL4/ANPEP/HSPA8/JUN/SNX3 46 GO:0042098 T cell proliferation 36/1165 199/18722 6.25451031307768e-09 6.88364046809902e-07 HLA-A/DLG5/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/PRDX2/CCND3/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/PTPRC/IL4I1/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/PYCARD/SLC11A1/PTPN6/TNFSF13B/MSN/LILRB2/LILRB4/IGF2/LILRB1/RPS3/SYK/PNP/HLA-DMB/TNFRSF1B 36 GO:1902105 regulation of leukocyte differentiation 44/1165 279/18722 1.10724771160088e-08 1.19518873177226e-06 FBN1/HLA-B/TYROBP/GATA3/PRKCZ/CDK6/GLI3/SOD1/PRDX2/HLA-DRA/FGL2/CEBPB/C1QC/FOS/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/EVI2B/CD86/IRF1/CD46/ESRRA/CD74/PTPN6/TGFB1/TREM2/LILRB2/LILRB4/IRF7/TMEM176B/BAD/LILRB1/NME1/ZFP36L1/LILRB3/JUN/SYK/ADAM8/PNP/CD83/LYN 44 GO:0042129 regulation of T cell proliferation 32/1165 171/18722 1.86216474033663e-08 1.97213786556783e-06 HLA-A/DLG5/TFRC/PAWR/HLA-E/CD24/HLA-DPA1/AIF1/CEBPB/DLG1/HLA-DRB1/HLA-DPB1/PTPRC/IL4I1/CD55/LGALS3/CD86/IRF1/CD46/IL6ST/PYCARD/PTPN6/TNFSF13B/LILRB2/LILRB4/IGF2/LILRB1/RPS3/SYK/PNP/HLA-DMB/TNFRSF1B 32 GO:0002501 peptide antigen assembly with MHC protein complex 10/1165 18/18722 2.31581390618419e-08 2.40715989915034e-06 B2M/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DPB1/CALR/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 10 GO:0048678 response to axon injury 21/1165 83/18722 2.36625349296236e-08 2.41486924654504e-06 DAG1/JAM3/ISL1/TYROBP/FOLR1/SOD1/AIF1/NREP/PTN/FLNA/MTR/KLF4/TREM2/ARF4/TXN2/TSPO/BNIP3/LRP1/JAK2/GRN/LYN 21 GO:0097193 intrinsic apoptotic signaling pathway 44/1165 288/18722 2.92073350717055e-08 2.92751378138362e-06 SOD2/CD44/PERP/PARP1/SOD1/CD24/SIAH1/HELLS/PHLDA3/HINT1/P4HB/CEBPB/PMAIP1/GPX1/S100A8/PRKDC/UBB/IFI6/SKIL/PLAUR/CRIP1/CD74/PYCARD/ARL6IP5/MDM2/TREM2/PARK7/ENO1/BCL2A1/RPS7/HRAS/USP47/ERO1A/BAD/PPIA/IFI16/FIS1/BCLAF1/BNIP3/NDUFS3/ERP29/RPS3/JAK2/TNFRSF1B 44 GO:0007568 aging 49/1165 339/18722 2.98834844204799e-08 2.94273680793252e-06 COL4A2/CTSV/MME/DAG1/B2M/SOD2/TFCP2L1/SERPINF1/APP/TIMP1/CDK6/SOD1/PAWR/ASS1/TBX3/RPN2/NPM1/PDCD4/GCLM/C1QA/ATP2B1/FOXO4/FOS/PRKDC/DNMT3A/SPI1/GRB2/SERP1/DLD/GPX4/CD68/LIMS1/RETN/BCL2A1/HRAS/KYNU/CALR/YBX1/ERO1A/TYMS/ROMO1/TSPO/APEX1/MBD2/ABI3/JUN/LRP1/YPEL3/TNFRSF1B 49 GO:0000302 response to reactive oxygen species 37/1165 222/18722 3.72238455009012e-08 3.6023697378717e-06 EGFR/MET/BMP7/SOD3/LDHA/SOD2/HSPD1/SOD1/PAWR/KLF2/NCF1/NET1/PRDX2/DUSP1/APOE/PRDX1/STAT1/SESN1/PRDX5/GPX1/FOS/GSTP1/KLF4/STK26/MDM2/TXNIP/PRDX3/PARK7/HDAC2/BAD/ROMO1/GCH1/APEX1/BNIP3/SLC8A1/JUN/RPS3 37 GO:0034341 response to interferon-gamma 28/1165 141/18722 3.80042458187216e-08 3.61555647085566e-06 IFITM3/ASS1/HSP90AB1/GAPDH/HLA-DPA1/GBP2/IFNGR2/AIF1/STAT1/GBP1/GBP4/CCL3L3/VIM/IFITM2/IRF1/CD74/SLC11A1/GBP5/HCK/KYNU/JAK1/TLR2/CXCL16/CCL4/BST2/GCH1/PARP9/JAK2 28 GO:0098869 cellular oxidant detoxification 23/1165 101/18722 4.3950478004835e-08 4.11156721735231e-06 BMP7/MGST3/SOD3/GPX8/SOD2/PRDX4/SOD1/PTGES/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/GSTO1/PRDX3/PARK7/PRDX6/GLRX/GCH1/GPX3 23 GO:0002483 antigen processing and presentation of endogenous peptide antigen 10/1165 19/18722 4.61561699400129e-08 4.2471242930048e-06 HLA-B/HLA-A/HLA-C/B2M/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/TAP1/TAPBP 10 GO:2000116 regulation of cysteine-type endopeptidase activity 38/1165 235/18722 5.59461133700491e-08 5.06492797332396e-06 PSMB9/CD44/HSPD1/PERP/LAPTM5/DHCR24/HSPE1/CTSH/PRDX5/PMAIP1/GPX1/LGMN/VCP/S100A8/SIAH2/RHOA/VEGFA/ASPH/IFI6/PLAUR/KLF4/TNFSF10/PYCARD/ARL6IP5/MDM2/PRDX3/PARK7/USP47/BAD/IFI16/FIS1/LAMTOR5/CYCS/RPS3/PDCD6/SYK/JAK2/NR4A1 38 GO:0002573 myeloid leukocyte differentiation 35/1165 208/18722 6.76811892080433e-08 5.96019947503582e-06 FBN1/TYROBP/APP/GATA3/PARP1/CDK6/TFRC/GPC3/SNX10/ITGB8/PIR/CEBPB/C1QC/FOS/HLA-DRB1/VEGFA/EVI2B/EIF2AK1/SPI1/ESRRA/CD74/JUNB/TGFB1/TREM2/LILRB4/IRF7/OSCAR/TLR2/LILRB1/NME1/IFI16/ZFP36L1/LILRB3/JUN/LYN 35 GO:0002831 regulation of response to biotic stimulus 47/1165 327/18722 6.79588039198811e-08 5.96019947503582e-06 HLA-B/HLA-A/TYROBP/CADM1/ISG15/HSPD1/CYBA/HSP90AB1/HLA-E/FCN1/NCF1/PRDX2/FGL2/APOE/HSP90AA1/STAT1/HLA-F/HLA-DRB1/PRKDC/HTRA1/IL4I1/C1QBP/CD55/SPI1/PLSCR1/A2M/IRF1/EIF2AK4/PYCARD/PTPN6/GBP5/TREM2/IRF7/OAS1/HCK/OASL/MNDA/IFIT1/FGR/LILRB1/IFI16/PARP9/SYK/ADAM8/LILRA2/GRN/LYN 47 GO:0002399 MHC class II protein complex assembly 9/1165 16/18722 1.04224239640504e-07 8.86379783488102e-06 B2M/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 9 GO:0002503 peptide antigen assembly with MHC class II protein complex 9/1165 16/18722 1.04224239640504e-07 8.86379783488102e-06 B2M/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB 9 GO:0019079 viral genome replication 26/1165 131/18722 1.16830649828511e-07 9.78761846996164e-06 IFITM3/HACD3/ISG15/DDB1/APOBEC3A/VCP/PPIB/IFITM2/MX1/PLSCR1/EIF2AK4/ISG20/NUCKS1/PABPC1/OAS1/RSAD2/OAS2/PHB/PPIA/OASL/IFIT1/IFI16/BST2/LAMTOR5/HSPA8/TOP2A 26 GO:0001667 ameboidal-type cell migration 60/1165 475/18722 1.3076415292299e-07 1.07938116228933e-05 SEMA6A/LAMA5/SEMA6D/KANK1/MET/NR2F2/ITGB4/DPP4/BMP7/LRP5/EPHB4/FERMT1/GJA1/ISL1/TACSTD2/SERPINF1/NRP2/FOLR1/GATA3/TIMP1/TMSB4X/AMOT/S100P/FSTL1/ARID5B/GPC3/MARVELD3/PDLIM1/ANXA3/PLPP3/EFNA1/NRP1/APOE/CTSH/ITGB1/PTN/ID1/GPX1/LGMN/RHOA/VEGFA/RAB25/C1QBP/PIK3C2A/KLF4/ATP2B4/CIB1/WASF2/TGFB1/ARHGDIB/CALR/RRAS/GLUL/CLN3/RAB11A/SLC8A1/PDCD6/ZEB2/GRN/NR4A1 60 GO:0007229 integrin-mediated signaling pathway 23/1165 107/18722 1.36411230346801e-07 1.10967570425593e-05 LAMA5/ITGB4/ADAMTS1/ITGA6/FERMT1/ISG15/TIMP1/ITGB5/FERMT2/PLPP3/NRP1/ITGB8/ITGB1/PTN/FUT8/VAV3/FLNA/DST/LIMS1/HCK/PTPRA/FGR/SYK 23 GO:0097237 cellular response to toxic substance 25/1165 124/18722 1.48157641882767e-07 1.18801263412567e-05 BMP7/MGST3/SOD3/GPX8/SOD2/PRDX4/SOD1/PTGES/ADH5/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/GSTO1/PRDX3/PARK7/PRDX6/GLRX/FIS1/GCH1/GPX3 25 GO:1990748 cellular detoxification 24/1165 116/18722 1.57262999610505e-07 1.24326368565319e-05 BMP7/MGST3/SOD3/GPX8/SOD2/PRDX4/SOD1/PTGES/ADH5/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/GSTO1/PRDX3/PARK7/PRDX6/GLRX/GCH1/GPX3 24 GO:0019883 antigen processing and presentation of endogenous antigen 11/1165 26/18722 1.67618267219993e-07 1.3067240748692e-05 HLA-B/HLA-A/HLA-C/B2M/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/CD74/TAP1/TAPBP 11 GO:0044409 entry into host 28/1165 151/18722 1.73810519034703e-07 1.33643622375587e-05 EGFR/DPP4/DAG1/IFITM3/CTSL/CXCR4/SLC52A1/TFRC/RPSA/FCN1/ITGB5/NRP1/P4HB/ITGB1/BSG/HLA-DRB1/IFITM2/CD55/CD86/PLSCR1/CD46/CD74/TRIM22/WWP1/PHB/FUCA2/ANPEP/SNX3 28 GO:1903829 positive regulation of cellular protein localization 41/1165 276/18722 1.88241143873307e-07 1.42783451427145e-05 CDH1/EGFR/TCAF1/TYROBP/SORBS1/ANK3/PARP1/TFRC/GLI3/HSP90AB1/FERMT2/YAP1/GNAI1/SLC5A3/NPM1/ITGB1/PTN/DLG1/FLNA/CCT2/LGALS3/RAN/ATP2B4/GNL3/CIB1/MSN/TGFB1/NMT1/TREM2/PARK7/HRAS/RHOG/FIS1/CLN3/LAMTOR5/RAB11A/PARP9/CD2AP/LRP1/SORL1/JAK2 41 GO:0070997 neuron death 49/1165 361/18722 2.16656894426304e-07 1.62146019788646e-05 ISL1/TYROBP/USP53/SOD2/SERPINF1/APP/GATA3/TFAP2A/HSPD1/PARP1/SOD1/HSP90AB1/ERBB3/DHCR24/RASA1/GAPDH/NRP1/SIAH1/SLC9A1/APOE/GCLM/HLA-F/C1QA/CEBPB/GPX1/LGMN/HSPA5/FOS/RHOA/UBB/PSMC1/ARL6IP5/TREM2/PARK7/HRAS/NENF/BAD/SET/SNX6/FIS1/CLN3/BNIP3/JUN/ADAM8/LRP1/SORL1/JAK2/TNFRSF1B/GRN 49 GO:0046718 viral entry into host cell 27/1165 144/18722 2.27216707799677e-07 1.67811497484156e-05 EGFR/DPP4/DAG1/IFITM3/CTSL/CXCR4/SLC52A1/TFRC/RPSA/FCN1/ITGB5/NRP1/P4HB/ITGB1/BSG/HLA-DRB1/IFITM2/CD55/CD86/PLSCR1/CD46/CD74/TRIM22/WWP1/PHB/ANPEP/SNX3 27 GO:0061458 reproductive system development 55/1165 427/18722 2.30610089341468e-07 1.68105770321255e-05 LRP2/ADGRG1/NR2F2/ADAMTS1/CTSV/BMP7/SPINT1/MME/LGR4/GJA1/KRT8/PHLDA2/SPINT2/SERPINF1/GATA3/PRDX4/RHOBTB3/GLI3/SOD1/ASPM/EPAS1/ARID5B/HSP90AB1/DHCR24/TBX3/NASP/ITGB8/TFAP2C/PLEKHA5/BSG/PTN/IDH1/CEBPB/DLG1/HSPA5/HTRA1/VEGFA/UBB/FLNA/GRB2/CRIP1/CCND1/TNFSF10/JUNB/PTPN6/BASP1/PRDX3/KRT19/EIF2S2/RETN/IGF2/SF1/CGA/ZFP36L1/SOCS3 55 GO:0051251 positive regulation of lymphocyte activation 49/1165 362/18722 2.35841639859533e-07 1.69715272375841e-05 HLA-A/DPP4/B2M/TYROBP/GATA3/PRKCZ/HSPD1/SLC39A10/TFRC/GLI3/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DRA/YES1/HLA-F/HLA-DRB1/PRKDC/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/TGFB1/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/LILRB1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/HLA-DMB/LYN 49 GO:0006457 protein folding 34/1165 212/18722 3.37718654757067e-07 2.39951241664736e-05 B2M/HSPD1/PRDX4/LMAN1/HSP90B1/HSP90AB1/HSPE1/PPIC/P4HB/ST13/HSP90AA1/PDIA6/HSPA5/BAG2/PPIB/PDIA4/DNAJB4/TBCA/CCT2/PFDN5/SIL1/CD74/TXNDC9/NUDCD2/CCDC47/CALR/ERO1A/PPIA/TTC1/SDF2/HSPA8/ERP29/FKBP2/GRN 34 GO:0052126 movement in host environment 30/1165 175/18722 3.81695647130561e-07 2.6780720841798e-05 EGFR/DPP4/DAG1/IFITM3/CTSL/CXCR4/SLC52A1/TFRC/RPSA/FCN1/ITGB5/DDB1/NRP1/P4HB/ITGB1/BSG/HLA-DRB1/IFITM2/CD55/CD86/PLSCR1/CD46/CD74/TRIM22/WWP1/PHB/PPIA/FUCA2/ANPEP/SNX3 30 GO:0050777 negative regulation of immune response 32/1165 194/18722 3.89353874377002e-07 2.69807814429396e-05 HLA-B/HLA-A/ISG15/HLA-E/CD59/FGL2/YES1/HLA-F/GPX1/HLA-DRB1/HTRA1/PTPRC/IL4I1/C1QBP/CD55/LGALS3/SPI1/A2M/CD46/PTPN6/TREM2/LILRB4/OAS1/HCK/FGR/LILRB1/IFI16/SYK/CD300A/PSMB4/GRN/LYN 32 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 11/1165 28/18722 4.14996493198204e-07 2.84070160527014e-05 HLA-B/HLA-A/HLA-C/B2M/HLA-E/FCER1G/HLA-F/IFI30/TAP1/CALR/TAPBP 11 GO:0048608 reproductive structure development 54/1165 424/18722 4.26697249724038e-07 2.86926072973135e-05 LRP2/ADGRG1/NR2F2/ADAMTS1/CTSV/BMP7/SPINT1/MME/LGR4/GJA1/KRT8/PHLDA2/SPINT2/SERPINF1/GATA3/PRDX4/RHOBTB3/GLI3/SOD1/ASPM/EPAS1/ARID5B/HSP90AB1/DHCR24/TBX3/NASP/ITGB8/TFAP2C/BSG/PTN/IDH1/CEBPB/DLG1/HSPA5/HTRA1/VEGFA/UBB/FLNA/GRB2/CRIP1/CCND1/TNFSF10/JUNB/PTPN6/BASP1/PRDX3/KRT19/EIF2S2/RETN/IGF2/SF1/CGA/ZFP36L1/SOCS3 54 GO:0042176 regulation of protein catabolic process 51/1165 391/18722 4.29392305892452e-07 2.86926072973135e-05 LRP2/CDH1/EGFR/GJA1/TIMP3/TIMP1/LAPTM5/HSP90AB1/GPC3/DDB1/EFNA1/RPL23/APOE/HSP90AA1/PSMD14/MAGEF1/PSME2/GPX1/OAZ1/VCP/DAB2/BAG2/PSMD1/UBB/PITHD1/PSMC1/FLNA/PSMC3/CST3/MYLIP/PSMC6/RPL5/MSN/MDM2/TREM2/USP14/PARK7/RAD23B/WWP1/RPS7/PHB/PSMC4/UFL1/PSME1/PSMD2/SNX3/ADAM8/LRP1/SORL1/ATRAID/TNFRSF1B 51 GO:0002697 regulation of immune effector process 46/1165 339/18722 5.11355648113392e-07 3.37675206218879e-05 HLA-B/HLA-A/B2M/TYROBP/CADM1/GATA3/PRKCZ/HSPD1/TFRC/LAPTM5/HLA-E/CD59/STXBP2/NCF1/HLA-DRA/FGL2/HLA-F/HLA-DRB1/PRKDC/PTPRC/IL4I1/C1QBP/CD55/LGALS3/DHX36/SPI1/CD86/A2M/DDX1/CD46/CD74/PTPN6/TGFB1/TREM2/LILRB4/RSAD2/PHB/FGR/LILRB1/BST2/SYK/CD300A/HLA-DMB/TNFRSF1B/GRN/LYN 46 GO:0032103 positive regulation of response to external stimulus 54/1165 427/18722 5.34249319890516e-07 3.48690864249473e-05 EGFR/MET/TYROBP/CXCR4/CADM1/APP/TMSB4X/HSPD1/CYBA/HLA-E/FCN1/NRP1/AIF1/NFKBIA/PDCD4/HSP90AA1/PTN/HLA-F/CEBPB/LGMN/S100A8/PRKDC/TGM2/VEGFA/C1QBP/FLNA/SPI1/PLSCR1/IL6ST/CD74/PYCARD/GBP5/TGFB1/TREM2/PARK7/GPSM3/IRF7/HCK/CALR/OASL/MNDA/S100A12/TLR2/CXCL10/CCL4/IFI16/PARP9/SYK/ADAM8/LRP1/JAK2/LILRA2/GRN/LYN 54 GO:0010952 positive regulation of peptidase activity 32/1165 197/18722 5.54673564406623e-07 3.57860082415446e-05 FBLN1/CLDN4/APP/PCOLCE2/HSPD1/PERP/LAPTM5/HSPE1/EFNA1/CTSH/PSMD14/PSME2/PMAIP1/LGMN/VCP/S100A8/RHOA/ASPH/TNFSF10/PYCARD/ARL6IP5/BAD/IFI16/PSME1/FIS1/CYCS/RPS3/PDCD6/SYK/JAK2/GRN/LYN 32 GO:0002443 leukocyte mediated immunity 55/1165 440/18722 6.1058012900592e-07 3.89452984557981e-05 HLA-B/HLA-A/B2M/TYROBP/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/FCER1G/ANXA3/HLA-DPA1/STXBP2/TUBB4B/HLA-DRA/CTSH/PRDX1/HLA-F/C1QA/TUBB/C1QB/C1QC/HLA-DRB1/S100A13/HLA-DPB1/PTPRC/IL4I1/C1QBP/CD55/DHX36/SPI1/TREM1/DDX1/CD46/CD74/PTPN6/TGFB1/TREM2/LILRB4/IRF7/RSAD2/MYO1G/HLA-DMA/HLA-DQA1/FGR/LILRB1/BST2/GAPT/HLA-DQA2/SYK/CD300A/HLA-DMB/TNFRSF1B/LYN 55 GO:0045088 regulation of innate immune response 34/1165 218/18722 6.58804679623373e-07 4.15491086148988e-05 HLA-B/HLA-A/TYROBP/CADM1/ISG15/HSP90AB1/HLA-E/FCN1/NCF1/APOE/HSP90AA1/HLA-F/PRKDC/SPI1/PLSCR1/A2M/IRF1/PYCARD/PTPN6/GBP5/TREM2/IRF7/OAS1/HCK/MNDA/FGR/LILRB1/IFI16/PARP9/SYK/ADAM8/LILRA2/GRN/LYN 34 GO:0045454 cell redox homeostasis 12/1165 35/18722 6.96801581190291e-07 4.34571919469011e-05 PRDX4/PRDX2/PRDX1/PRDX5/GPX1/SLC11A1/DLD/PRDX3/PRDX6/ERO1A/TXN2/APEX1 12 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33/1165 209/18722 7.20664804999304e-07 4.43722377258031e-05 CD44/HSPD1/LAPTM5/DHCR24/HSPE1/CTSH/PRDX5/PMAIP1/GPX1/VCP/S100A8/SIAH2/RHOA/VEGFA/IFI6/PLAUR/KLF4/TNFSF10/PYCARD/ARL6IP5/MDM2/PRDX3/PARK7/USP47/BAD/FIS1/LAMTOR5/CYCS/RPS3/PDCD6/SYK/JAK2/NR4A1 33 GO:0050867 positive regulation of cell activation 53/1165 420/18722 7.27284138744679e-07 4.43722377258031e-05 HLA-A/DPP4/B2M/TYROBP/GATA3/PRKCZ/HSPD1/SLC39A10/TFRC/GLI3/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DRA/YES1/HLA-F/HLA-DRB1/PRKDC/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/TGFB1/TREM2/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/FGR/LILRB1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/JAK2/LILRA2/HLA-DMB/LYN 53 GO:0045637 regulation of myeloid cell differentiation 33/1165 210/18722 8.04987981320383e-07 4.85849197758205e-05 FBN1/B2M/TYROBP/ISG15/CDK6/SCIN/NFKBIA/ZFP36/STAT1/CEBPB/C1QC/FOS/HLA-DRB1/PRKDC/PITHD1/EVI2B/FAM210B/SPI1/ESRRA/CD74/CIB1/TGFB1/TREM2/LILRB4/IRF7/CSF3R/LILRB1/NME1/ZFP36L1/LILRB3/PRMT1/JUN/LYN 33 GO:2001233 regulation of apoptotic signaling pathway 47/1165 356/18722 8.5605325564983e-07 5.11173077017287e-05 MAGED1/ITGA6/TIMP3/SOD2/CD44/PARP1/SOD1/YAP1/NRP1/SIAH1/PRDX2/HELLS/ITM2C/P4HB/TNFRSF12A/CTSH/GCLM/PMAIP1/GPX1/S100A8/SIAH2/PTPRC/UBB/SLC25A5/IFI6/GSTP1/LGALS3/SKIL/PLAUR/CD74/TNFSF10/PYCARD/MDM2/TREM2/PARK7/ENO1/RPS7/USP47/BAD/PPIA/GNAI2/FIS1/BCLAF1/NDUFS3/ERP29/RPS3/PEA15 47 GO:0045069 regulation of viral genome replication 19/1165 85/18722 8.75749541183374e-07 5.12293562203777e-05 IFITM3/HACD3/ISG15/DDB1/APOBEC3A/IFITM2/MX1/PLSCR1/ISG20/PABPC1/OAS1/RSAD2/OAS2/PPIA/OASL/IFIT1/IFI16/BST2/TOP2A 19 GO:0033108 mitochondrial respiratory chain complex assembly 20/1165 93/18722 8.76183537708223e-07 5.12293562203777e-05 TFAM/NDUFB7/NDUFS5/NDUFAB1/COA4/NDUFA6/NDUFC2/UQCC2/NDUFB10/NDUFB2/COX20/NDUFB9/NDUFA10/NDUFB1/NDUFB11/NDUFA11/NDUFA5/NDUFS3/NDUFS8/SCO2 20 GO:0007162 negative regulation of cell adhesion 42/1165 303/18722 9.0050646909078e-07 5.21086887732634e-05 CDH1/SEMA6A/KANK1/FBLN1/JAM3/DLG5/TACSTD2/SPINT2/GLI3/PAWR/LAPTM5/ASS1/ERBB3/RASA1/PRDX2/FGL2/DUSP1/CEBPB/DLG1/GBP1/FXYD5/HLA-DRB1/RHOA/VEGFA/PTPRC/IL4I1/LGALS3/SPI1/CD9/CD86/IRF1/KLF4/CD74/PTPN6/TGFB1/LILRB2/LILRB4/ARHGDIB/LILRB1/LRP1/CD300A/JAK2 42 GO:0009636 response to toxic substance 38/1165 262/18722 9.61261343734759e-07 5.4500605276598e-05 CDH1/BMP7/MGST3/SLC6A4/SOD3/GPX8/SOD2/PON2/PRDX4/SOD1/PTGES/ASS1/ADH5/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/FOS/GSTP1/DNMT3A/GPX4/MDM2/GSTO1/PRDX3/PARK7/DHX15/PRDX6/GLRX/TYMS/TLR2/CCL4/FIS1/GCH1/GPX3/CCNB1/LYN 38 GO:0010466 negative regulation of peptidase activity 38/1165 262/18722 9.61261343734759e-07 5.4500605276598e-05 ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/CD44/GPC3/DHCR24/GAPDH/PRDX5/GPX1/SIAH2/VEGFA/IFI6/PLAUR/CST3/A2M/KLF4/APLP2/MDM2/PRDX3/USP14/PARK7/USP47/IFI16/BST2/LAMTOR5/CST6/LRP1/SORL1/TFPI2/NR4A1 38 GO:0050792 regulation of viral process 28/1165 164/18722 1.00604864696981e-06 5.55154910702168e-05 IFITM3/HACD3/CXCR4/ISG15/FCN1/DDB1/APOBEC3A/P4HB/ZFP36/STAT1/HLA-DRB1/IFITM2/MX1/PLSCR1/CD74/ISG20/TRIM22/PABPC1/OAS1/RSAD2/OAS2/PPIA/OASL/IFIT1/IFI16/BST2/SNX3/TOP2A 28 GO:2001242 regulation of intrinsic apoptotic signaling pathway 28/1165 164/18722 1.00604864696981e-06 5.55154910702168e-05 SOD2/CD44/PARP1/SOD1/SIAH1/HELLS/P4HB/PMAIP1/GPX1/S100A8/UBB/SKIL/PLAUR/CD74/PYCARD/MDM2/TREM2/PARK7/ENO1/RPS7/USP47/BAD/PPIA/FIS1/BCLAF1/NDUFS3/ERP29/RPS3 28 GO:0050900 leukocyte migration 48/1165 369/18722 1.01072469657079e-06 5.55154910702168e-05 DPP4/JAM3/CXCR4/APP/GATA3/FLT1/FCER1G/AIF1/DUSP1/YES1/ITGB1/BSG/PTN/LGMN/S100A8/PECAM1/PPIB/RHOA/VEGFA/VAV3/C1QBP/CCL3L3/LGALS3/EPS8/SPI1/CD9/TREM1/CD74/PYCARD/MSN/ST3GAL4/TREM2/GPSM3/HCK/MYO1G/CALR/CSF3R/PPIA/WASL/S100A12/CXCL10/CXCL16/CCL4/RHOG/SYK/ADAM8/CD300A/LYN 48 GO:0002819 regulation of adaptive immune response 30/1165 183/18722 1.01872360239307e-06 5.55154910702168e-05 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/CD48/PTPRC/IL4I1/CD55/IRF1/EIF2AK4/CD46/IL6ST/PYCARD/SLC11A1/PTPN6/TNFSF13B/TGFB1/TREM2/LILRB4/IRF7/RSAD2/LILRB1/TNFRSF1B 30 GO:0062197 cellular response to chemical stress 45/1165 337/18722 1.06424575434277e-06 5.74385713377496e-05 EGFR/MET/BMP7/PAGE4/SLC2A1/SOD3/GPX8/SOD2/PARP1/SOD1/PAWR/EPAS1/KLF2/AIF1/NCF1/NET1/PRDX2/P4HB/PRDX1/AKR1B1/PRDX5/GPX1/FUT8/FOS/ETV5/KLF4/STK26/ARL6IP5/MDM2/PRDX3/TREM2/PARK7/HDAC2/BAD/PPIA/ROMO1/CLN3/GCH1/TSPO/APEX1/BNIP3/ZFP36L1/JUN/RPS3/JAK2 45 GO:0043254 regulation of protein-containing complex assembly 53/1165 427/18722 1.21173405866335e-06 6.47698369821146e-05 KANK1/MET/FERMT1/JAM3/ISL1/LMO4/ISG15/PRKCZ/TMSB4X/PARP1/TFRC/KANK4/RASA1/FERMT2/SCIN/TMSB10/MPP7/COTL1/APOE/HSP90AA1/LCP1/DLG1/HSPA5/VCP/RHOA/VEGFA/CLIP1/ARPC3/LGALS3/EPS8/GMFG/GRB2/ARPC5L/PSMC6/AKAP9/PYCARD/WASF2/GBP5/MSN/TGFB1/TREM2/PARK7/TRIOBP/HCK/STMN1/VASP/WASL/ADD3/HSPA8/IQGAP2/RPS3/SYK/SORL1 53 GO:1905475 regulation of protein localization to membrane 29/1165 175/18722 1.22316100482882e-06 6.47698369821146e-05 EGFR/TCAF1/DAG1/SORBS1/PRKCZ/ANK3/GPC3/GPC1/SLC5A3/ITGB1/PTN/DLG1/GBP1/DAB2/LGALS3/CLTC/ATP2B4/CIB1/TGFB1/NMT1/TREM2/HRAS/RHOG/FIS1/ACTB/CLN3/ABI3/RAB11A/LRP1 29 GO:0031667 response to nutrient levels 57/1165 474/18722 1.34695039760133e-06 6.90224772668437e-05 EGFR/CTSV/BMP7/KRT18/PAGE4/SLC2A1/SLC6A4/ADRB1/LDHA/SOD2/FOLR1/AGL/SOD1/CYBA/ASS1/CYBB/APOE/COMT/PTN/ZFP36/GCLM/STAT1/SESN1/ATP2B1/PMAIP1/HSPA5/FOXO4/GSTP1/UPP1/EIF2AK1/DNMT3A/COX4I1/EIF2AK4/CCND1/STK26/MDM2/CD68/GDF15/KYNU/NENF/TXN2/TYMS/GNAI2/CXCL10/GLUL/IFI16/FIS1/SRSF2/TSPO/BNIP3/MBD2/SLC8A1/HSPA8/JUN/SORL1/GABARAPL1/ENSA 57 GO:1902107 positive regulation of leukocyte differentiation 27/1165 157/18722 1.35004140514266e-06 6.90224772668437e-05 TYROBP/GATA3/PRKCZ/GLI3/HLA-DRA/FOS/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/EVI2B/CD86/CD46/CD74/TGFB1/TREM2/LILRB2/LILRB4/BAD/ZFP36L1/JUN/SYK/ADAM8/PNP/CD83 27 GO:1903708 positive regulation of hemopoiesis 27/1165 157/18722 1.35004140514266e-06 6.90224772668437e-05 TYROBP/GATA3/PRKCZ/GLI3/HLA-DRA/FOS/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/EVI2B/CD86/CD46/CD74/TGFB1/TREM2/LILRB2/LILRB4/BAD/ZFP36L1/JUN/SYK/ADAM8/PNP/CD83 27 GO:0010257 NADH dehydrogenase complex assembly 15/1165 57/18722 1.37537882568307e-06 6.90224772668437e-05 NDUFB7/NDUFS5/NDUFAB1/NDUFA6/NDUFC2/NDUFB10/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFB11/NDUFA11/NDUFA5/NDUFS3/NDUFS8 15 GO:0032981 mitochondrial respiratory chain complex I assembly 15/1165 57/18722 1.37537882568307e-06 6.90224772668437e-05 NDUFB7/NDUFS5/NDUFAB1/NDUFA6/NDUFC2/NDUFB10/NDUFB2/NDUFB9/NDUFA10/NDUFB1/NDUFB11/NDUFA11/NDUFA5/NDUFS3/NDUFS8 15 GO:0045730 respiratory burst 12/1165 37/18722 1.377252352376e-06 6.90224772668437e-05 CYBA/CYBB/CD24/NCF2/NCF1/PRDX2/CD55/SLC11A1/CD52/TREM2/HCK/GRN 12 GO:0007015 actin filament organization 54/1165 441/18722 1.46615815863184e-06 7.22577593179806e-05 KANK1/MET/CALD1/TACSTD2/SORBS1/ALDOA/TMSB4X/RHOBTB3/PAWR/KANK4/HSP90B1/TJP1/ITGB5/RASA1/FERMT2/SCIN/TMSB10/DSTN/PDLIM1/LIMA1/S100A10/NRP1/AIF1/SLC9A1/COTL1/MYO7A/ID1/LCP1/DLG1/RND3/RHOA/ARPC3/FLNA/EPS8/GMFG/GRB2/ARPC5L/RHOBTB1/PYCARD/WASF2/MARCKSL1/TRIOBP/HCK/MYO1G/STMN1/VASP/WASL/ADD3/RHOG/IQGAP2/CD2AP/WIPF1/MYO1F/JAK2 54 GO:0032970 regulation of actin filament-based process 50/1165 396/18722 1.46755470554958e-06 7.22577593179806e-05 KANK1/MET/GJA5/DSP/DSG2/JAM3/TACSTD2/TMSB4X/RHOBTB3/DSC2/KANK4/TJP1/RASA1/FERMT2/SCIN/TMSB10/DSTN/LIMA1/S100A10/NRP1/SLC9A1/COTL1/ID1/DLG1/RND3/RHOA/ARPC3/FLNA/EPS8/GMFG/GRB2/ARPC5L/RHOBTB1/AKAP9/PYCARD/WASF2/TRIOBP/HCK/ARHGDIB/HRAS/STMN1/VASP/WASL/ADD3/RHOG/BST2/ABI3/IQGAP2/CD2AP/LRP1 50 GO:0051402 neuron apoptotic process 36/1165 246/18722 1.48771756437897e-06 7.26135538161666e-05 ISL1/TYROBP/USP53/SOD2/APP/GATA3/TFAP2A/HSPD1/PARP1/SOD1/HSP90AB1/ERBB3/RASA1/GAPDH/NRP1/SIAH1/APOE/GCLM/CEBPB/GPX1/LGMN/HSPA5/RHOA/TREM2/PARK7/HRAS/SET/SNX6/FIS1/CLN3/BNIP3/JUN/ADAM8/LRP1/JAK2/GRN 36 GO:0002696 positive regulation of leukocyte activation 51/1165 409/18722 1.67554965091975e-06 8.10763809535568e-05 HLA-A/DPP4/B2M/TYROBP/GATA3/PRKCZ/HSPD1/SLC39A10/TFRC/GLI3/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DRA/YES1/HLA-F/HLA-DRB1/PRKDC/HLA-DPB1/RHOA/PTPRC/IL4I1/SOX4/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/PTPN6/TNFSF13B/TGFB1/TREM2/LILRB2/LILRB4/IGF2/HLA-DMA/BAD/HLA-DQA1/FGR/LILRB1/HLA-DQA2/RPS3/SYK/ADAM8/PNP/CD83/HLA-DMB/LYN 51 GO:0009266 response to temperature stimulus 29/1165 178/18722 1.74696292491522e-06 8.38094264747789e-05 ADRB1/SOD2/CXCR4/HSPD1/SOD1/NR2F6/HSP90AB1/RBBP7/SLC9A1/NFKBIA/HSP90AA1/ATP2B1/VCP/CD14/FOS/DNAJB4/DHX36/EIF2AK4/PLAC8/HSBP1L1/HDAC2/ERO1A/CXCL10/YWHAE/TFEC/PDCD6/CIRBP/ACADVL/LYN 29 GO:0150105 protein localization to cell-cell junction 9/1165 21/18722 2.0147726422181e-06 9.58382952607642e-05 DSP/LSR/DLG5/TJP1/MPP7/PECAM1/FLNA/JAK1/ACTB 9 GO:0072001 renal system development 41/1165 302/18722 2.07681156703914e-06 9.79591876116864e-05 FBN1/LRP2/LAMA5/ADAMTS6/LGR5/MAGED1/PBX1/ADAMTS1/BMP7/ENPEP/MME/LGR4/DLG5/FRAS1/TACSTD2/SERPINF1/GATA3/TFAP2A/GLI3/IRX2/ASS1/ARID5B/GPC3/CD24/YAP1/NRP1/CTSH/STAT1/AKR1B1/DLG1/AP1B1/PECAM1/RHOA/VEGFA/HPGD/SOX4/HSPB11/BASP1/CENPF/C1GALT1/SULF2 41 GO:0006801 superoxide metabolic process 17/1165 74/18722 2.18434918140538e-06 0.000101328528555607 EGFR/BMP7/SOD3/TYROBP/SOD2/SOD1/CYBA/CYBB/NCF2/NCF1/PRDX2/PRDX1/GSTP1/TGFB1/GNAI2/GCH1/SYK 17 GO:0051881 regulation of mitochondrial membrane potential 17/1165 74/18722 2.18434918140538e-06 0.000101328528555607 PARP1/SOD1/BNIP3L/GCLM/PMAIP1/VCP/HEBP2/UBB/IFI6/SLC25A36/ARL6IP5/STOML2/PRDX3/PARK7/BAD/TSPO/BNIP3 17 GO:0001822 kidney development 40/1165 293/18722 2.39646066799977e-06 0.000110256833848219 FBN1/LRP2/LAMA5/ADAMTS6/MAGED1/PBX1/ADAMTS1/BMP7/ENPEP/MME/LGR4/DLG5/FRAS1/TACSTD2/SERPINF1/GATA3/TFAP2A/GLI3/IRX2/ASS1/ARID5B/GPC3/CD24/YAP1/NRP1/CTSH/STAT1/AKR1B1/DLG1/AP1B1/PECAM1/RHOA/VEGFA/HPGD/SOX4/HSPB11/BASP1/CENPF/C1GALT1/SULF2 40 GO:1901653 cellular response to peptide 46/1165 359/18722 2.56427715892833e-06 0.000117018599130607 FBN1/KANK1/GJA1/SORBS1/APP/PRKCZ/PARP1/CYBA/ASS1/IGF1R/KLF2/SLC9A1/RPL23/KLF5/CCND3/STAT1/AKR1B1/ATP2B1/ID1/LGMN/FOXO4/PRKDC/GSTP1/VIM/GRB2/PIK3C2A/ESRRA/KLF4/NUCKS1/MDM2/PKM/GDF15/TREM2/IGF2/PTPRA/GNAI2/SNX6/FIS1/APEX1/ZFP36L1/SOCS3/LRP1/SORL1/JAK2/LYN/NR4A1 46 GO:0051604 protein maturation 40/1165 294/18722 2.61116714941182e-06 0.000117482469234158 SRGN/ENPEP/MME/CTSL/SERPINH1/CTSS/HSPD1/PRDX4/GCSH/PERP/PARP1/GLI3/DHCR24/CTSH/MAGEF1/PISD/LGMN/BAG2/PRKACB/ASPH/SOX4/AFG3L2/NDUFAB1/PMPCB/PYCARD/PGK1/MDM2/STOML2/GLRX5/ENO1/METAP2/CALR/CPM/ERO1A/NAA10/BAD/IFI16/CLN3/ADAM8/SORL1 40 GO:0045582 positive regulation of T cell differentiation 19/1165 91/18722 2.61630298490464e-06 0.000117482469234158 GATA3/PRKCZ/GLI3/HLA-DRA/HLA-DRB1/RHOA/PTPRC/IL4I1/SOX4/CD86/CD46/CD74/LILRB2/LILRB4/BAD/SYK/ADAM8/PNP/CD83 19 GO:0010951 negative regulation of endopeptidase activity 36/1165 252/18722 2.63814840127967e-06 0.000117523229971292 ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/CD44/DHCR24/GAPDH/PRDX5/GPX1/SIAH2/VEGFA/IFI6/PLAUR/CST3/A2M/KLF4/APLP2/MDM2/PRDX3/USP14/PARK7/USP47/IFI16/BST2/LAMTOR5/CST6/SORL1/TFPI2/NR4A1 36 GO:0003018 vascular process in circulatory system 37/1165 263/18722 2.78253888062269e-06 0.000122979454621537 LRP2/EGFR/GJA5/SLC2A1/SLC16A12/SLC6A4/ADRB1/SLC38A1/SOD3/GJA1/SOD2/SLC19A1/TFRC/SOD1/TJP1/FERMT2/SLC13A3/KLF2/SLC5A3/APOE/YES1/GCLM/ATP2B1/GPX1/RHOA/VEGFA/SLC5A6/PIK3C2A/ATP2B4/SLC1A3/TGFB1/SLC29A1/SLC2A3/SLCO2B1/GCH1/SLC8A1/LRP1 37 GO:0009410 response to xenobiotic stimulus 55/1165 462/18722 2.80543732045768e-06 0.000123022809997882 CDH1/EGFR/SLC6A4/ADIRF/LDHA/B2M/SOD2/CXCR4/GATA3/HSPD1/TFRC/SOD1/CYBA/ASS1/HSP90AB1/CYBB/APOBEC3A/GGH/S100A10/RPN2/COMT/FBP1/GSTA4/PTN/GCLM/STAT1/GPX1/HSPA5/FOS/RHOA/VAV3/GSTP1/MCM7/DNMT3A/PLIN2/SLC1A3/MDM2/TXNIP/GSTO1/CENPF/USP47/HDAC2/CALR/TXN2/BAD/TYMS/S100A12/NME1/TSPO/APEX1/SLC8A1/JUN/PNP/CCNB1/LYN 55 GO:0097305 response to alcohol 36/1165 253/18722 2.89568733526372e-06 0.00012599606986694 CDH1/TGFBR3/DAG1/SOD2/GATA3/PARP1/SOD1/CYBA/CYBB/GGH/KLF2/GNAI1/PSMD14/ATP2B1/CDO1/S100A8/CD14/FOS/RHOA/HPGD/GSTP1/EPS8/DNMT3A/SPI1/CCND1/KLF4/TGFB1/MDM2/PMVK/FDX1/HDAC2/BAD/TYMS/TSPO/RPL10A/RGS19 36 GO:0045862 positive regulation of proteolysis 47/1165 372/18722 2.959167705162e-06 0.000127767756377494 FBLN1/CLDN4/APP/PCOLCE2/HSPD1/PERP/LAPTM5/HSPE1/EFNA1/APOE/CTSH/PSMD14/MAGEF1/PSME2/PMAIP1/LGMN/VCP/S100A8/DAB2/BAG2/RHOA/AURKAIP1/ASPH/PSMC1/PSMC3/PSMC6/TNFSF10/PYCARD/ARL6IP5/MDM2/TREM2/ENO1/HDAC2/BAD/PSMC4/IFI16/PSME1/FIS1/CYCS/RPS3/PDCD6/SYK/ADAM8/JAK2/TNFRSF1B/GRN/LYN 47 GO:0048545 response to steroid hormone 44/1165 339/18722 2.99916460225834e-06 0.000128506190171573 EGFR/CTSV/CLDN4/BMP7/ISL1/SERPINF1/AGL/HSPD1/PARP1/CYBA/ASS1/CYBB/RBBP7/ESRRG/ANXA3/YAP1/AIF1/DUSP1/PTN/ZFP36/IDH1/ATP2B1/CDO1/SKP2/DAB2/FOS/RHOA/GSTP1/CCND1/ESRRA/TGFB1/MDM2/TXNIP/PARK7/CALR/PHB/BAD/TYMS/UFL1/TLR2/PGRMC2/TSPO/ZFP36L1/JAK2 44 GO:0048525 negative regulation of viral process 19/1165 92/18722 3.10727277723316e-06 0.000132129712868256 IFITM3/ISG15/FCN1/APOBEC3A/ZFP36/STAT1/IFITM2/MX1/PLSCR1/ISG20/OAS1/RSAD2/OAS2/PPIA/OASL/IFIT1/IFI16/BST2/SNX3 19 GO:0001666 response to hypoxia 41/1165 307/18722 3.15936135035947e-06 0.000132504050302823 TGFBR3/DPP4/BMP7/SLC2A1/SLC6A4/SOD3/LDHA/SOD2/CXCR4/HSPD1/CYBA/HSP90B1/EPAS1/CYBB/CD24/PDLIM1/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/RHOA/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/ERO1A/TXN2/BAD/TLR2/FIS1/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 41 GO:0051701 biological process involved in interaction with host 31/1165 203/18722 3.18677202952672e-06 0.000132504050302823 EGFR/DPP4/DAG1/IFITM3/CTSL/CXCR4/SLC52A1/TFRC/RPSA/FCN1/ITGB5/DDB1/NRP1/P4HB/ITGB1/BSG/HLA-DRB1/IFITM2/CD55/CD86/PLSCR1/CD46/CD74/TRIM22/WWP1/PHB/PPIA/IFIT1/FUCA2/ANPEP/SNX3 31 GO:0010038 response to metal ion 47/1165 373/18722 3.18689591856068e-06 0.000132504050302823 CDH1/EGFR/HSD17B1/SOD3/B2M/SOD2/SERPINF1/APP/TFAP2A/SYT7/ANK3/PARP1/SOD1/PTGES/ASS1/CYBB/GGH/NCF1/DUSP1/FBP1/BSG/C1QA/LGMN/HSPA5/S100A8/CD14/FOS/CYB5A/CUTA/DNMT3A/PLSCR1/CRIP1/CCND1/FUS/JUNB/MDM2/TXNIP/PARK7/SLC25A13/CALR/BAD/TSPO/BNIP3/JUN/PDCD6/AQP9/CCNB1 47 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 8/1165 17/18722 3.2170994775928e-06 0.000132776318880356 HLA-B/HLA-A/HLA-C/B2M/HLA-E/HLA-F/TAP1/TAPBP 8 GO:0034614 cellular response to reactive oxygen species 26/1165 155/18722 3.40120767956253e-06 0.000139126546438582 EGFR/MET/BMP7/SOD3/SOD2/SOD1/PAWR/KLF2/NCF1/NET1/PRDX2/PRDX1/PRDX5/FOS/KLF4/STK26/MDM2/PRDX3/PARK7/HDAC2/ROMO1/GCH1/APEX1/BNIP3/JUN/RPS3 26 GO:0042102 positive regulation of T cell proliferation 20/1165 101/18722 3.42053508079892e-06 0.000139126546438582 HLA-A/TFRC/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DPB1/PTPRC/CD55/CD86/CD46/IL6ST/PYCARD/TNFSF13B/LILRB2/IGF2/RPS3/SYK/PNP/HLA-DMB 20 GO:1901654 response to ketone 30/1165 194/18722 3.52082803702898e-06 0.00014217559548089 EGFR/TGFBR3/CLDN4/SERPINF1/PARP1/CYBA/ASS1/CYBB/YAP1/NASP/KLF2/GNAI1/DUSP1/PTN/AKR1B1/ATP2B1/FOS/CCND1/KLF4/MSN/TGFB1/TXNIP/PARK7/FDX1/CALR/BAD/TYMS/TLR2/NME1/TSPO 30 GO:0002698 negative regulation of immune effector process 21/1165 110/18722 3.62584492538189e-06 0.00014537048261549 HLA-B/HLA-A/HLA-E/CD59/FGL2/HLA-F/PRKDC/PTPRC/IL4I1/CD55/LGALS3/SPI1/A2M/CD46/PTPN6/TGFB1/LILRB4/LILRB1/BST2/CD300A/GRN 21 GO:0010720 positive regulation of cell development 40/1165 298/18722 3.66101959355218e-06 0.000145739737436939 LRP2/EGFR/SPINT1/MME/DAG1/TYROBP/CXCR4/SERPINF1/GLI3/ASPM/OBSL1/FERMT2/S100A10/NRP1/P4HB/PTN/GOLGA4/PRKDC/TGM2/VEGFA/ETV5/C1QBP/FLNA/SKIL/DHX36/IL6ST/CIB1/TGFB1/LIMS1/TRIOBP/HDAC2/CALR/BAD/UFL1/TLR2/TSPO/RAB11A/LRP1/TNFRSF1B/LYN 40 GO:0002253 activation of immune response 47/1165 375/18722 3.69203025068773e-06 0.000145939195754297 HLA-A/TYROBP/GATA3/SLC39A10/PAWR/LAPTM5/FCN1/FCER1G/CD59/KCNN4/YES1/HSP90AA1/C1QA/GBP1/C1QB/C1QC/HLA-DRB1/PRKDC/HLA-DPB1/PTPRC/VAV3/C1QBP/CD55/LGALS3/PLSCR1/A2M/CD46/PYCARD/PTPN6/STOML2/TREM2/LILRB4/HCK/FPR1/MYO1G/HRAS/FPR3/PHB/MNDA/FGR/IFI16/CFP/RPS3/SYK/CD300A/LILRA2/LYN 47 GO:0034599 cellular response to oxidative stress 39/1165 288/18722 3.89324204422448e-06 0.000152816556603021 EGFR/MET/BMP7/PAGE4/SOD3/GPX8/SOD2/PARP1/SOD1/PAWR/EPAS1/KLF2/AIF1/NCF1/NET1/PRDX2/P4HB/PRDX1/PRDX5/GPX1/FUT8/FOS/ETV5/KLF4/STK26/ARL6IP5/MDM2/PRDX3/TREM2/PARK7/HDAC2/PPIA/ROMO1/GCH1/APEX1/BNIP3/JUN/RPS3/JAK2 39 GO:0031349 positive regulation of defense response 38/1165 278/18722 4.12445978153832e-06 0.000160768005234546 EGFR/GJA1/TYROBP/CADM1/APP/HSPD1/CYBA/HLA-E/FCN1/NFKBIA/PDCD4/HSP90AA1/HLA-F/CEBPB/S100A8/PRKDC/TGM2/SPI1/PLSCR1/IL6ST/PYCARD/GBP5/TREM2/PARK7/GPSM3/IRF7/HCK/MNDA/S100A12/TLR2/IFI16/PARP9/SYK/ADAM8/JAK2/LILRA2/GRN/LYN 38 GO:0002703 regulation of leukocyte mediated immunity 33/1165 226/18722 4.21984686606834e-06 0.000163351727305114 HLA-B/HLA-A/B2M/TYROBP/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/STXBP2/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/IL4I1/CD55/DHX36/SPI1/DDX1/CD46/PTPN6/TGFB1/TREM2/LILRB4/RSAD2/FGR/LILRB1/BST2/SYK/CD300A/TNFRSF1B/LYN 33 GO:2000377 regulation of reactive oxygen species metabolic process 26/1165 157/18722 4.33903410583142e-06 0.000166815057781039 EGFR/BMP7/PAGE4/TYROBP/SOD2/TFAP2A/HSPD1/SOD1/CYBA/PRDX2/SLC5A3/RHOA/STK17A/GSTP1/DCXR/GRB2/TGFB1/PARK7/ARF4/GNAI2/ROMO1/GCH1/TSPO/BNIP3/VDAC1/SYK 26 GO:0002263 cell activation involved in immune response 38/1165 279/18722 4.4950139849856e-06 0.000171636146243022 TYROBP/APP/GATA3/PRKCZ/HSPD1/TFRC/FCER1G/ANXA3/STXBP2/HLA-DRA/FGL2/HLA-F/LCP1/HLA-DRB1/S100A13/PTPRC/LGALS3/SPI1/CD86/EIF2AK4/CD46/CD74/PYCARD/SLC11A1/TGFB1/TREM2/APBB1IP/FGR/DOCK10/LILRB1/GAPT/SYK/LRP1/CD300A/LILRA2/HLA-DMB/GRN/LYN 38 GO:1903900 regulation of viral life cycle 25/1165 148/18722 4.58501115651518e-06 0.000173889646091349 IFITM3/HACD3/ISG15/FCN1/DDB1/APOBEC3A/P4HB/HLA-DRB1/IFITM2/MX1/PLSCR1/CD74/ISG20/TRIM22/PABPC1/OAS1/RSAD2/OAS2/PPIA/OASL/IFIT1/IFI16/BST2/SNX3/TOP2A 25 GO:0002821 positive regulation of adaptive immune response 21/1165 112/18722 4.88601592183113e-06 0.000184061794424417 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/EIF2AK4/IL6ST/PYCARD/SLC11A1/TNFSF13B/TGFB1/TREM2/RSAD2 21 GO:0032956 regulation of actin cytoskeleton organization 45/1165 357/18722 5.08537999992944e-06 0.00019029491959736 KANK1/MET/JAM3/TACSTD2/TMSB4X/RHOBTB3/KANK4/TJP1/RASA1/FERMT2/SCIN/TMSB10/DSTN/LIMA1/S100A10/NRP1/SLC9A1/COTL1/ID1/DLG1/RND3/RHOA/ARPC3/FLNA/EPS8/GMFG/GRB2/ARPC5L/RHOBTB1/PYCARD/WASF2/TRIOBP/HCK/ARHGDIB/HRAS/STMN1/VASP/WASL/ADD3/RHOG/BST2/ABI3/IQGAP2/CD2AP/LRP1 45 GO:0007179 transforming growth factor beta receptor signaling pathway 30/1165 198/18722 5.37038099179834e-06 0.000198315450703711 FBN1/FBN2/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/PARP1/HSP90AB1/ITGB5/FERMT2/ITGB8/NREP/ID1/FUT8/HSPA5/DAB2/FOS/HTRA1/HPGD/LATS2/SKIL/SPI1/EID2/TGFB1/GDF15/SNX6/JUN/ZEB2 30 GO:0031099 regeneration 30/1165 198/18722 5.37038099179834e-06 0.000198315450703711 EGFR/TGFBR3/DAG1/JAM3/ISL1/FOLR1/GLI3/ANXA3/YAP1/KLF5/NREP/PTN/LCP1/CEBPB/GPX1/FLNA/GSTP1/MTR/CD9/CCND1/KLF4/ATIC/RPS16/TYMS/TSPO/SULF2/LRP1/JAK2/CCNB1/GRN 30 GO:1903131 mononuclear cell differentiation 51/1165 426/18722 5.46657541169779e-06 0.000199359262075376 HLA-B/PBX1/CTSL/B2M/GATA3/PRKCZ/CDK6/GLI3/SOD1/FCER1G/ITGB8/PRDX2/HLA-DRA/PIR/FGL2/ITGB1/CEBPB/HLA-DRB1/PRKDC/RHOA/VEGFA/PTPRC/SLC25A5/IL4I1/SOX4/SPI1/CD86/IRF1/CD46/CD74/PTPN6/TNFSF13B/TREM2/LILRB2/LILRB4/IRF7/TMEM176B/RSAD2/KLF6/BAD/DOCK10/KDELR1/LILRB1/IFI16/ZFP36L1/JUN/SYK/ADAM8/PNP/CD83/LYN 51 GO:0045621 positive regulation of lymphocyte differentiation 20/1165 104/18722 5.4696822304664e-06 0.000199359262075376 GATA3/PRKCZ/GLI3/HLA-DRA/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/CD86/CD46/CD74/LILRB2/LILRB4/BAD/SYK/ADAM8/PNP/CD83 20 GO:0051222 positive regulation of protein transport 40/1165 303/18722 5.52118912905469e-06 0.000199938287621832 CDH1/EGFR/MYH10/TCAF1/WLS/GJA1/ISL1/EXPH5/PRKCZ/ANK3/FRMD4A/GLI3/HSP90AB1/KCNN4/MPC2/OAZ1/HLA-DRB1/SOX4/FLNA/RAN/SERP1/CIB1/TGFB1/MDM2/NMT1/TREM2/HRAS/BAD/PPIA/PCM1/TLR2/GLUL/YWHAE/FIS1/CLN3/CD2AP/ADAM8/LRP1/SORL1/JAK2 40 GO:0071560 cellular response to transforming growth factor beta stimulus 35/1165 250/18722 5.72460742532844e-06 0.000205975778707491 FBN1/FBN2/COL4A2/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/PARP1/HSP90AB1/ITGB5/FERMT2/ITGB8/NREP/YES1/ID1/FUT8/HSPA5/DAB2/FOS/HTRA1/HPGD/LATS2/SKIL/SPI1/EID2/TGFB1/GDF15/LIMS1/HDAC2/SNX6/ZFP36L1/JUN/ZEB2 35 GO:0070665 positive regulation of leukocyte proliferation 25/1165 150/18722 5.8655213973664e-06 0.000209701729958074 HLA-A/SLC39A10/TFRC/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DPB1/PTPRC/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/TNFSF13B/LILRB2/IGF2/BST2/RPS3/SYK/PNP/HLA-DMB/LYN 25 GO:0045071 negative regulation of viral genome replication 14/1165 56/18722 5.94921181811703e-06 0.000211347632500575 IFITM3/ISG15/APOBEC3A/IFITM2/MX1/PLSCR1/ISG20/OAS1/RSAD2/OAS2/OASL/IFIT1/IFI16/BST2 14 GO:0048872 homeostasis of number of cells 37/1165 272/18722 6.15589609286791e-06 0.000217314746976526 ADGRG1/TGFBR3/LGR4/JAM3/B2M/GATA3/ISG15/RPS17/CDK6/SOD1/EPAS1/FSTL1/KLF2/PRDX2/PRDX1/ZFP36/STAT1/PMAIP1/PRKDC/VEGFA/SLC25A5/SOX4/SKIL/FAM210B/SPI1/CD74/RPS14/TNFSF13B/TSC22D3/UFL1/DOCK10/LIPA/GAPT/ZFP36L1/PRMT1/JAK2/LYN 37 GO:0009409 response to cold 13/1165 49/18722 6.27859082881147e-06 0.000220260814513242 ADRB1/SOD2/HSPD1/SLC9A1/NFKBIA/HSP90AA1/ATP2B1/FOS/EIF2AK4/PLAC8/CXCL10/CIRBP/ACADVL 13 GO:0001655 urogenital system development 43/1165 338/18722 6.48367324161285e-06 0.00022562793956046 FBN1/LRP2/LAMA5/ADAMTS6/LGR5/MAGED1/PBX1/ADAMTS1/BMP7/ENPEP/MME/LGR4/DLG5/FRAS1/TACSTD2/SERPINF1/GATA3/TFAP2A/GLI3/IRX2/ASS1/ARID5B/GPC3/CD24/YAP1/NRP1/HELLS/CTSH/STAT1/AKR1B1/DLG1/AP1B1/PECAM1/RHOA/VEGFA/HPGD/SOX4/CRIP1/HSPB11/BASP1/CENPF/C1GALT1/SULF2 43 GO:0050866 negative regulation of cell activation 31/1165 210/18722 6.51197687667816e-06 0.00022562793956046 DLG5/TYROBP/GLI3/PAWR/LAPTM5/PRDX2/FGL2/APOE/HLA-F/CEBPB/DLG1/HLA-DRB1/LST1/PTPRC/IL4I1/LGALS3/SPI1/CD9/CD86/IRF1/CD74/PTPN6/TREM2/LILRB2/LILRB4/MNDA/FGR/LILRB1/CD300A/GRN/LYN 31 GO:0043409 negative regulation of MAPK cascade 28/1165 180/18722 6.56331612522056e-06 0.000226011616017564 SEMA6A/FBLN1/BMP7/DAG1/DUSP9/TIMP3/PEBP1/DUSP5/MARVELD3/IGF1R/EFNA1/DUSP1/APOE/PDCD4/DLG1/GBP1/PTPRC/GSTP1/KLF4/PTPN6/EIF3A/TREM2/LILRB4/PHB/PPIA/SORL1/CD300A/LYN 28 GO:1900024 regulation of substrate adhesion-dependent cell spreading 14/1165 57/18722 7.43836674588625e-06 0.000253201964212419 KANK1/FBLN1/TACSTD2/FERMT2/S100A10/NRP1/P4HB/GBP1/C1QBP/FLNA/CIB1/LIMS1/TRIOBP/CALR 14 GO:0045861 negative regulation of proteolysis 44/1165 351/18722 7.44313630768737e-06 0.000253201964212419 ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/CD44/HSP90AB1/GPC3/DHCR24/GAPDH/EFNA1/RPL23/PRDX5/GPX1/SIAH2/VEGFA/IFI6/PLAUR/CST3/A2M/KLF4/APLP2/RPL5/MDM2/PRDX3/USP14/PARK7/RPS7/USP47/IFI16/BST2/CLN3/LAMTOR5/CST6/LRP1/SORL1/TFPI2/NR4A1 44 GO:0002237 response to molecule of bacterial origin 45/1165 363/18722 7.8726614722601e-06 0.000266200294239734 GJA1/B2M/GNG12/SOD2/HSPD1/PTGES/ASS1/CD24/ADH5/PRDX2/NFKBIA/PDCD4/COMT/ZFP36/CEBPB/S100A8/CD14/FOS/RHOA/HPGD/GSTP1/VIM/CD55/SPI1/CD86/PYCARD/SLC11A1/TGFB1/CD68/PRDX3/TREM2/LILRB2/HCK/HDAC2/TLR2/LILRB1/CXCL10/GCH1/TSPO/JUN/JAK2/LILRA2/TNFRSF1B/LYN/NR4A1 45 GO:1904951 positive regulation of establishment of protein localization 41/1165 319/18722 8.22577647036014e-06 0.000276474750467853 CDH1/EGFR/MYH10/TCAF1/WLS/GJA1/ISL1/EXPH5/PRKCZ/ANK3/FRMD4A/GLI3/HSP90AB1/KCNN4/MPC2/OAZ1/HLA-DRB1/SOX4/FLNA/CCT2/RAN/SERP1/CIB1/TGFB1/MDM2/NMT1/TREM2/HRAS/BAD/PPIA/PCM1/TLR2/GLUL/YWHAE/FIS1/CLN3/CD2AP/ADAM8/LRP1/SORL1/JAK2 41 GO:1904375 regulation of protein localization to cell periphery 22/1165 125/18722 8.55624070775355e-06 0.000285870113646552 EGFR/DAG1/SORBS1/PRKCZ/GNAI1/ITGB1/DLG1/GBP1/DAB2/LGALS3/CLTC/ATP2B4/CIB1/TGFB1/TREM2/HRAS/RHOG/ACTB/CLN3/ABI3/RAB11A/LRP1 22 GO:0001890 placenta development 24/1165 144/18722 8.95313788183009e-06 0.000296767883688949 NR2F2/CTSV/BMP7/SPINT1/MME/GJA1/KRT8/PHLDA2/SPINT2/SOD1/EPAS1/HSP90AB1/ITGB8/BSG/PTN/CEBPB/HTRA1/GRB2/JUNB/PRDX3/KRT19/IGF2/ZFP36L1/SOCS3 24 GO:0042060 wound healing 50/1165 422/18722 8.98815966989513e-06 0.000296767883688949 F5/EGFR/KANK1/FBLN1/DSP/CLDN4/DAG1/FERMT1/GJA1/SERPINA1/CXCR4/TIMP1/CD44/SYT7/LMAN1/GLI3/ERBB3/FERMT2/FCER1G/CD59/PLPP3/YAP1/PRDX2/TNFRSF12A/APOE/ITGB1/GNAS/GPX1/S100A8/RHOA/VEGFA/VAV3/FLNA/PLAUR/CD9/PLSCR1/IL6ST/AK3/SLC11A1/PTPN6/TGFB1/ST3GAL4/DST/HRAS/PPIA/ACTB/SYK/JAK2/TFPI2/LYN 50 GO:0032496 response to lipopolysaccharide 43/1165 343/18722 9.40214674286628e-06 0.000307424419059544 GJA1/GNG12/SOD2/HSPD1/PTGES/ASS1/ADH5/PRDX2/NFKBIA/PDCD4/COMT/ZFP36/CEBPB/S100A8/CD14/FOS/RHOA/HPGD/GSTP1/VIM/CD55/SPI1/CD86/PYCARD/SLC11A1/TGFB1/CD68/PRDX3/TREM2/LILRB2/HCK/HDAC2/TLR2/LILRB1/CXCL10/GCH1/TSPO/JUN/JAK2/LILRA2/TNFRSF1B/LYN/NR4A1 43 GO:0001101 response to acid chemical 23/1165 135/18722 9.42045253487289e-06 0.000307424419059544 KRT8/SLC38A9/CYBA/ASS1/CYBB/KLF2/PTN/GCLM/SESN1/DNMT1/AKR1B1/CDO1/CEBPB/RHOA/VEGFA/GSTP1/DNMT3A/CD9/ATP2B4/BAD/UFL1/LAMTOR5/LYN 23 GO:0071559 response to transforming growth factor beta 35/1165 256/18722 9.72415605597524e-06 0.000315501086371035 FBN1/FBN2/COL4A2/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/PARP1/HSP90AB1/ITGB5/FERMT2/ITGB8/NREP/YES1/ID1/FUT8/HSPA5/DAB2/FOS/HTRA1/HPGD/LATS2/SKIL/SPI1/EID2/TGFB1/GDF15/LIMS1/HDAC2/SNX6/ZFP36L1/JUN/ZEB2 35 GO:0002699 positive regulation of immune effector process 33/1165 235/18722 9.82935969070435e-06 0.000316416083086073 HLA-B/HLA-A/B2M/TYROBP/CADM1/GATA3/PRKCZ/HSPD1/TFRC/LAPTM5/HLA-E/STXBP2/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/DHX36/SPI1/CD86/DDX1/CD46/CD74/TGFB1/TREM2/RSAD2/PHB/FGR/LILRB1/SYK/CD300A/HLA-DMB/LYN 33 GO:0014015 positive regulation of gliogenesis 15/1165 66/18722 9.86510146803186e-06 0.000316416083086073 LRP2/EGFR/SPINT1/DAG1/CXCR4/PTN/ETV5/IL6ST/TGFB1/HDAC2/UFL1/TLR2/TSPO/TNFRSF1B/LYN 15 GO:0036293 response to decreased oxygen levels 41/1165 322/18722 1.03395159246709e-05 0.000329748311847601 TGFBR3/DPP4/BMP7/SLC2A1/SLC6A4/SOD3/LDHA/SOD2/CXCR4/HSPD1/CYBA/HSP90B1/EPAS1/CYBB/CD24/PDLIM1/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/RHOA/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/ERO1A/TXN2/BAD/TLR2/FIS1/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 41 GO:1900180 regulation of protein localization to nucleus 23/1165 136/18722 1.06813256811244e-05 0.00033872475168447 CDH1/MAGED1/FERMT1/PARP1/TFRC/GLI3/HSP90AB1/TRIM29/FERMT2/YAP1/NPM1/LATS2/FLNA/CCT2/RAN/TGFB1/PARK7/LILRB4/GLUL/LAMTOR5/PARP9/CD2AP/JAK2 23 GO:0019221 cytokine-mediated signaling pathway 54/1165 472/18722 1.10669153355444e-05 0.00034898087515961 KRT18/IFITM3/KRT8/CXCR4/ISG15/CD44/TMSB4X/LAPTM5/HSP90AB1/CD24/FCER1G/PRLR/YAP1/IFNGR2/NFKBIA/P4HB/STAT1/PTPRC/CCL3L3/GSTP1/IFITM2/MX1/SPI1/IRF1/IL6ST/CD74/CIB1/PYCARD/PTPN6/TNFSF13B/TREM2/LILRB2/LIMS1/LILRB4/IRF7/OAS1/HCK/PLP2/JAK1/OAS2/CSF3R/BAD/OASL/LILRB1/CXCL10/CCL4/LILRB3/PARP9/SYK/IL10RB/JAK2/LILRA2/TNFRSF1B/CSF2RA 54 GO:0042542 response to hydrogen peroxide 24/1165 146/18722 1.13938272852647e-05 0.000356736057881407 MET/LDHA/SOD2/HSPD1/SOD1/PAWR/KLF2/NET1/DUSP1/STAT1/GPX1/KLF4/STK26/MDM2/TXNIP/PRDX3/PARK7/HDAC2/BAD/APEX1/BNIP3/SLC8A1/JUN/RPS3 24 GO:0002456 T cell mediated immunity 20/1165 109/18722 1.14399590982814e-05 0.000356736057881407 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/HLA-E/HLA-DRA/CTSH/HLA-F/HLA-DRB1/PTPRC/IL4I1/CD55/CD46/LILRB4/RSAD2/MYO1G/LILRB1/TNFRSF1B 20 GO:0031334 positive regulation of protein-containing complex assembly 33/1165 237/18722 1.17699265147903e-05 0.000364997776395125 MET/FERMT1/ISG15/TFRC/FERMT2/SCIN/MPP7/HSP90AA1/LCP1/DLG1/VCP/RHOA/VEGFA/CLIP1/ARPC3/LGALS3/GMFG/GRB2/ARPC5L/PSMC6/AKAP9/PYCARD/WASF2/GBP5/MSN/TGFB1/PARK7/HCK/VASP/WASL/IQGAP2/RPS3/SYK 33 GO:0050671 positive regulation of lymphocyte proliferation 23/1165 137/18722 1.20931010403349e-05 0.00037295920955714 HLA-A/SLC39A10/TFRC/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DPB1/PTPRC/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/TNFSF13B/LILRB2/IGF2/RPS3/SYK/PNP/HLA-DMB 23 GO:0022408 negative regulation of cell-cell adhesion 29/1165 196/18722 1.22285626269622e-05 0.000375076076640101 CDH1/DLG5/SPINT2/GLI3/PAWR/LAPTM5/ASS1/PRDX2/FGL2/CEBPB/DLG1/FXYD5/HLA-DRB1/VEGFA/IL4I1/LGALS3/SPI1/CD9/CD86/IRF1/KLF4/CD74/PTPN6/TGFB1/LILRB2/LILRB4/LILRB1/CD300A/JAK2 29 GO:0031103 axon regeneration 13/1165 52/18722 1.27509552765325e-05 0.000388973434604222 DAG1/JAM3/ISL1/FOLR1/NREP/PTN/FLNA/MTR/KLF4/TSPO/LRP1/JAK2/GRN 13 GO:0051250 negative regulation of lymphocyte activation 25/1165 157/18722 1.33385081678813e-05 0.000404697547817933 DLG5/TYROBP/GLI3/PAWR/LAPTM5/PRDX2/FGL2/HLA-F/CEBPB/DLG1/HLA-DRB1/LST1/IL4I1/LGALS3/CD86/IRF1/CD74/PTPN6/LILRB2/LILRB4/MNDA/FGR/LILRB1/CD300A/LYN 25 GO:0032946 positive regulation of mononuclear cell proliferation 23/1165 138/18722 1.36716095944176e-05 0.000411189558234252 HLA-A/SLC39A10/TFRC/HLA-E/CD24/HLA-DPA1/AIF1/HLA-DPB1/PTPRC/VAV3/CD55/CD86/CD46/IL6ST/CD74/PYCARD/TNFSF13B/LILRB2/IGF2/RPS3/SYK/PNP/HLA-DMB 23 GO:0002695 negative regulation of leukocyte activation 28/1165 187/18722 1.36989929431329e-05 0.000411189558234252 DLG5/TYROBP/GLI3/PAWR/LAPTM5/PRDX2/FGL2/HLA-F/CEBPB/DLG1/HLA-DRB1/LST1/PTPRC/IL4I1/LGALS3/SPI1/CD86/IRF1/CD74/PTPN6/LILRB2/LILRB4/MNDA/FGR/LILRB1/CD300A/GRN/LYN 28 GO:0007163 establishment or maintenance of cell polarity 31/1165 218/18722 1.40352764146199e-05 0.000418383748508121 KANK1/FERMT1/JAM3/GJA1/DLG5/SPINT2/MAP7/GATA3/PRKCZ/RHOBTB3/FRMD4A/AMOT/HSP90AB1/WEE1/MPP7/PDLIM1/SLC9A1/PARD6B/FRMD4B/HSP90AA1/ITGB1/DLG1/RND3/RHOA/RHOBTB1/MSN/DST/ARF4/CCL4/RHOG/ACTB 31 GO:0032930 positive regulation of superoxide anion generation 8/1165 20/18722 1.40877478118715e-05 0.000418383748508121 EGFR/TYROBP/SOD1/CYBA/GSTP1/TGFB1/GNAI2/SYK 8 GO:0034101 erythrocyte homeostasis 22/1165 129/18722 1.43839511697236e-05 0.000424932199556097 TGFBR3/B2M/GATA3/ISG15/RPS17/CDK6/EPAS1/KLF2/PRDX1/ZFP36/STAT1/PRKDC/VEGFA/SLC25A5/FAM210B/SPI1/RPS14/UFL1/ZFP36L1/PRMT1/JAK2/LYN 22 GO:0045185 maintenance of protein location 18/1165 93/18722 1.45072424441774e-05 0.000426330637901401 FBN1/FBN2/SRGN/GJA1/LTBP1/TMSB4X/ANK3/SCIN/TMSB10/NFKBIA/HSPA5/GPAA1/FLNA/PARK7/KDELR1/TSPO/KDELR2/SORL1 18 GO:0048569 post-embryonic animal organ development 7/1165 15/18722 1.46633007666485e-05 0.00042867243334999 FBN1/EFEMP1/LDHA/MYO7A/VEGFA/KLF4/HMGN1 7 GO:0035456 response to interferon-beta 10/1165 32/18722 1.52993432623256e-05 0.00044494929394525 IFITM3/STAT1/IFITM2/PLSCR1/IRF1/XAF1/OAS1/MNDA/IFI16/BST2 10 GO:0002709 regulation of T cell mediated immunity 17/1165 85/18722 1.58821533480486e-05 0.00045951817908555 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/IL4I1/CD55/LILRB4/RSAD2/LILRB1/TNFRSF1B 17 GO:0097529 myeloid leukocyte migration 31/1165 220/18722 1.68759097195051e-05 0.000480101950109862 DPP4/JAM3/FLT1/FCER1G/AIF1/DUSP1/BSG/LGMN/S100A8/PECAM1/PPIB/VEGFA/VAV3/C1QBP/CCL3L3/LGALS3/SPI1/CD9/TREM1/CD74/TREM2/CSF3R/PPIA/S100A12/CXCL10/CCL4/RHOG/SYK/ADAM8/CD300A/LYN 31 GO:1902414 protein localization to cell junction 18/1165 94/18722 1.69136741096551e-05 0.000480101950109862 DSP/DAG1/JAM3/LSR/DLG5/NSG1/PRKCZ/TJP1/MARVELD3/FERMT2/MPP7/DLG1/PECAM1/FLNA/HRAS/JAK1/ACTB/RAB11A 18 GO:1990830 cellular response to leukemia inhibitory factor 18/1165 94/18722 1.69136741096551e-05 0.000480101950109862 NRP2/PCOLCE2/TFRC/ARID5B/SNX10/KLF5/HELLS/MRPL15/GCLM/SRM/SLC25A5/EPS8/KLF4/RPS16/TLE4/RNMT/NCL/SOCS3 18 GO:0010950 positive regulation of endopeptidase activity 27/1165 179/18722 1.69357181759759e-05 0.000480101950109862 HSPD1/PERP/LAPTM5/HSPE1/EFNA1/CTSH/PSMD14/PSME2/PMAIP1/LGMN/VCP/S100A8/RHOA/ASPH/TNFSF10/PYCARD/ARL6IP5/BAD/IFI16/PSME1/FIS1/CYCS/RPS3/PDCD6/SYK/JAK2/LYN 27 GO:1901222 regulation of NIK/NF-kappaB signaling 20/1165 112/18722 1.73768296832262e-05 0.000488090890967363 EGFR/BMP7/APP/TMSB4X/LAPTM5/NFKBIA/PDCD4/PRDX1/CD14/RHOA/SPI1/CD86/TRIP6/TREM2/LIMS1/CALR/PHB/TLR2/NFAT5/RPS3 20 GO:0031589 cell-substrate adhesion 44/1165 363/18722 1.74249013109412e-05 0.000488090890967363 LAMA5/BCAM/KANK1/CCDC80/LAMB1/FBLN1/ITGB4/ITGA6/DAG1/FERMT1/JAM3/LAMC1/TACSTD2/SORBS1/CD44/PRKCZ/CDK6/ITGB5/RASA1/FERMT2/EFNA1/S100A10/NRP1/SLC9A1/P4HB/ITGB1/PTN/ID1/GBP1/RHOA/VEGFA/C1QBP/FLNA/CIB1/TRIP6/LIMS1/TRIOBP/MYO1G/CALR/PTPRA/RRAS/UTRN/LRP1/JAK2 44 GO:1901224 positive regulation of NIK/NF-kappaB signaling 15/1165 69/18722 1.74784017609906e-05 0.000488090890967363 EGFR/APP/LAPTM5/PDCD4/CD14/RHOA/CD86/TRIP6/TREM2/LIMS1/CALR/PHB/TLR2/NFAT5/RPS3 15 GO:0002764 immune response-regulating signaling pathway 53/1165 468/18722 1.77120074688003e-05 0.000492165831298891 HLA-A/LGR4/COLEC12/TYROBP/CTSS/GATA3/HSPD1/SLC39A10/PAWR/CYBA/LAPTM5/FCN1/CD24/FCER1G/KCNN4/NFKBIA/YES1/CTSH/GBP1/CD14/HLA-DRB1/HLA-DPB1/PTPRC/VAV3/CLEC4E/C1QBP/LGALS3/PLSCR1/IRF1/PTPN6/STOML2/TREM2/LILRB2/LILRB4/IRF7/OAS1/HCK/FPR1/RSAD2/MYO1G/HRAS/FPR3/PHB/OASL/MNDA/FGR/TLR2/LILRB1/RPS3/SYK/CD300A/LILRA2/LYN 53 GO:0046683 response to organophosphorus 22/1165 131/18722 1.84728877591844e-05 0.000510779896513802 SLC6A4/LDHA/APP/HSPD1/SOD1/HSP90B1/ASS1/DUSP1/BSG/STAT1/CDO1/HSPA5/FOS/AKAP9/FDX1/TYMS/NME1/APEX1/ZFP36L1/SLC8A1/JUN/AQP9 22 GO:1901214 regulation of neuron death 40/1165 319/18722 1.89507470658125e-05 0.000521424231766695 ISL1/TYROBP/SOD2/SERPINF1/GATA3/TFAP2A/HSPD1/PARP1/SOD1/HSP90AB1/ERBB3/DHCR24/RASA1/NRP1/APOE/GCLM/HLA-F/C1QA/CEBPB/LGMN/FOS/RHOA/UBB/PSMC1/TREM2/PARK7/HRAS/NENF/BAD/SET/SNX6/FIS1/CLN3/JUN/ADAM8/LRP1/SORL1/JAK2/TNFRSF1B/GRN 40 GO:0002366 leukocyte activation involved in immune response 36/1165 275/18722 1.92468628900476e-05 0.000526893889578525 TYROBP/GATA3/PRKCZ/HSPD1/TFRC/FCER1G/ANXA3/STXBP2/HLA-DRA/FGL2/HLA-F/LCP1/HLA-DRB1/S100A13/PTPRC/LGALS3/SPI1/CD86/EIF2AK4/CD46/CD74/PYCARD/SLC11A1/TGFB1/TREM2/APBB1IP/FGR/DOCK10/LILRB1/GAPT/SYK/CD300A/LILRA2/HLA-DMB/GRN/LYN 36 GO:1990266 neutrophil migration 21/1165 122/18722 1.9337277971348e-05 0.000526893889578525 DPP4/JAM3/FCER1G/BSG/S100A8/PECAM1/PPIB/VAV3/C1QBP/CCL3L3/LGALS3/TREM1/CD74/CSF3R/PPIA/S100A12/CXCL10/CCL4/RHOG/SYK/ADAM8 21 GO:0050764 regulation of phagocytosis 18/1165 95/18722 1.96705086770541e-05 0.000530820025020694 SYT7/SOD1/CYBA/FCER1G/TGM2/PTPRC/PLSCR1/PYCARD/SLC11A1/TREM2/HCK/CALR/FGR/TLR2/SNX3/SYK/LRP1/CD300A 18 GO:1990823 response to leukemia inhibitory factor 18/1165 95/18722 1.96705086770541e-05 0.000530820025020694 NRP2/PCOLCE2/TFRC/ARID5B/SNX10/KLF5/HELLS/MRPL15/GCLM/SRM/SLC25A5/EPS8/KLF4/RPS16/TLE4/RNMT/NCL/SOCS3 18 GO:0071456 cellular response to hypoxia 24/1165 151/18722 2.03447688081968e-05 0.000546388456078511 BMP7/EPAS1/CYBB/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/ERO1A/BAD/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 24 GO:0022604 regulation of cell morphogenesis 39/1165 309/18722 2.06505397701774e-05 0.000551532964143445 KANK1/MYH10/FBLN1/CLDN4/DAG1/TACSTD2/CXCR4/ALDOA/CD44/RHOBTB3/OBSL1/RASA1/FERMT2/S100A10/NRP1/P4HB/PTN/DLG1/RND3/GBP1/PRKDC/RHOA/VEGFA/LST1/C1QBP/FLNA/EPS8/DHX36/RHOBTB1/CIB1/MSN/PLEKHO1/LIMS1/TRIOBP/HCK/CALR/FGR/RHOG/FMNL1 39 GO:0002431 Fc receptor mediated stimulatory signaling pathway 10/1165 33/18722 2.0732844367409e-05 0.000551532964143445 FCER1G/YES1/PTPRC/VAV3/PLSCR1/HCK/MYO1G/FGR/SYK/LYN 10 GO:1900182 positive regulation of protein localization to nucleus 17/1165 87/18722 2.18674438544933e-05 0.000578971520543729 CDH1/PARP1/TFRC/GLI3/HSP90AB1/FERMT2/YAP1/NPM1/FLNA/CCT2/RAN/TGFB1/PARK7/LAMTOR5/PARP9/CD2AP/JAK2 17 GO:0010811 positive regulation of cell-substrate adhesion 21/1165 123/18722 2.19733470307767e-05 0.000579044116825116 CCDC80/ITGA6/DAG1/FERMT1/PRKCZ/CDK6/FERMT2/S100A10/NRP1/P4HB/PTN/VEGFA/C1QBP/FLNA/CIB1/LIMS1/TRIOBP/CALR/RRAS/UTRN/JAK2 21 GO:0098754 detoxification 24/1165 152/18722 2.2759865957925e-05 0.000596967886083332 BMP7/MGST3/SOD3/GPX8/SOD2/PRDX4/SOD1/PTGES/ADH5/PRDX2/APOE/PRDX1/SESN1/PRDX5/GPX1/GSTP1/GPX4/GSTO1/PRDX3/PARK7/PRDX6/GLRX/GCH1/GPX3 24 GO:0050673 epithelial cell proliferation 50/1165 437/18722 2.31551996390287e-05 0.000604512258483107 EGFR/LGR5/NR2F2/LAMB1/TGFBR3/MAGED1/LGR4/FERMT1/GJA1/ISL1/LAMC1/B2M/CDKN1C/SERPINF1/NRP2/GATA3/CDK6/CYBA/GPC3/MARVELD3/FLT1/YAP1/NRP1/APOE/PTN/ZFP36/IRF6/STAT1/ID1/CEBPB/DLG1/GPX1/DLX5/PRKDC/HTRA1/VEGFA/CCND1/TGFB1/MYDGF/HRAS/IGF2/BAD/GLUL/NME1/ZFP36L1/SULF2/HMGN1/PDCD6/GRN/NR4A1 50 GO:0051346 negative regulation of hydrolase activity 45/1165 379/18722 2.36188574312811e-05 0.000613762253526763 ITIH5/CRIM1/SPINT1/SERPINH1/TIMP3/SERPINA1/SPINT2/PEBP1/SERPINF1/APP/TIMP1/CD44/PRKCZ/AMOT/GPC3/DHCR24/GAPDH/CNN3/PRDX5/GPX1/SIAH2/VEGFA/IFI6/LGALS3/PLAUR/CST3/A2M/APOC1/KLF4/APLP2/MDM2/PRDX3/USP14/PARK7/HRAS/USP47/GNAI2/IFI16/BST2/LAMTOR5/CST6/LRP1/SORL1/TFPI2/NR4A1 45 GO:0002704 negative regulation of leukocyte mediated immunity 14/1165 63/18722 2.54601925906079e-05 0.000657930059091091 HLA-B/HLA-A/HLA-E/HLA-F/PTPRC/IL4I1/CD55/SPI1/CD46/PTPN6/LILRB4/LILRB1/BST2/CD300A 14 GO:0010232 vascular transport 17/1165 88/18722 2.55529579337e-05 0.000657930059091091 LRP2/SLC2A1/SLC16A12/SLC38A1/GJA1/SLC19A1/TFRC/SLC13A3/SLC5A3/APOE/SLC5A6/ATP2B4/SLC1A3/SLC29A1/SLC2A3/SLCO2B1/LRP1 17 GO:1905477 positive regulation of protein localization to membrane 19/1165 106/18722 2.64920725648757e-05 0.000678995448888802 EGFR/TCAF1/SORBS1/ANK3/SLC5A3/ITGB1/PTN/DLG1/LGALS3/ATP2B4/CIB1/NMT1/TREM2/HRAS/RHOG/FIS1/CLN3/RAB11A/LRP1 19 GO:0050678 regulation of epithelial cell proliferation 45/1165 381/18722 2.69198265080955e-05 0.000686822664499727 EGFR/NR2F2/LAMB1/TGFBR3/MAGED1/GJA1/ISL1/LAMC1/B2M/CDKN1C/SERPINF1/NRP2/GATA3/CDK6/CYBA/GPC3/MARVELD3/FLT1/YAP1/NRP1/APOE/PTN/ZFP36/STAT1/ID1/DLG1/GPX1/DLX5/PRKDC/HTRA1/VEGFA/CCND1/TGFB1/MYDGF/HRAS/IGF2/BAD/GLUL/NME1/ZFP36L1/SULF2/HMGN1/PDCD6/GRN/NR4A1 45 GO:0070482 response to oxygen levels 42/1165 347/18722 2.77877181520068e-05 0.00070575774654848 TGFBR3/DPP4/BMP7/SLC2A1/SLC6A4/SOD3/LDHA/SOD2/CXCR4/HSPD1/CYBA/HSP90B1/EPAS1/CYBB/CD24/PDLIM1/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/RHOA/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/HDAC2/ERO1A/TXN2/BAD/TLR2/FIS1/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 42 GO:0007584 response to nutrient 26/1165 174/18722 2.84731061294765e-05 0.000716679572667049 EGFR/BMP7/SLC6A4/LDHA/SOD2/FOLR1/AGL/ASS1/CYBB/PTN/GCLM/STAT1/ATP2B1/GSTP1/DNMT3A/COX4I1/CCND1/MDM2/KYNU/TYMS/GNAI2/CXCL10/SRSF2/TSPO/SLC8A1/ENSA 26 GO:0045619 regulation of lymphocyte differentiation 26/1165 174/18722 2.84731061294765e-05 0.000716679572667049 GATA3/PRKCZ/GLI3/SOD1/PRDX2/HLA-DRA/FGL2/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/CD86/IRF1/CD46/CD74/PTPN6/LILRB2/LILRB4/BAD/ZFP36L1/SYK/ADAM8/PNP/CD83 26 GO:1902903 regulation of supramolecular fiber organization 45/1165 382/18722 2.87244505627582e-05 0.00071977830807483 KANK1/MET/TACSTD2/APP/TMSB4X/KANK4/TJP1/RASA1/FERMT2/SCIN/TMSB10/DSTN/LIMA1/S100A10/NRP1/SLC9A1/COTL1/APOE/ID1/DLG1/GPX1/RHOA/CLIP1/ARPC3/FLNA/EPS8/GMFG/GRB2/ARPC5L/PFDN5/AKAP9/CIB1/PYCARD/WASF2/TREM2/PARK7/TRIOBP/HCK/STMN1/VASP/WASL/ADD3/HSPA8/IQGAP2/RPS3 45 GO:0002711 positive regulation of T cell mediated immunity 13/1165 56/18722 3.00781752571272e-05 0.000750350212081133 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/RSAD2 13 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 19/1165 107/18722 3.03614634686714e-05 0.000754065904644481 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/CD14/PTPRC/CD86/PYCARD/OAS1/HDAC2/OAS2/TLR2/SYK/ADAM8/JAK2/LILRA2 19 GO:0002367 cytokine production involved in immune response 18/1165 98/18722 3.05030477320511e-05 0.000754244964405299 HLA-A/B2M/GATA3/PRKCZ/LAPTM5/HLA-E/HLA-F/CD55/DHX36/TREM1/DDX1/CD74/TGFB1/LILRB4/RSAD2/LILRB1/BST2/TNFRSF1B 18 GO:0038094 Fc-gamma receptor signaling pathway 9/1165 28/18722 3.18373777678569e-05 0.000782554161054527 FCER1G/YES1/PTPRC/VAV3/HCK/MYO1G/FGR/SYK/LYN 9 GO:2001235 positive regulation of apoptotic signaling pathway 21/1165 126/18722 3.1926759822107e-05 0.000782554161054527 MAGED1/TIMP3/SOD1/SIAH1/ITM2C/TNFRSF12A/CTSH/PMAIP1/S100A8/PTPRC/UBB/SKIL/TNFSF10/PYCARD/PARK7/RPS7/BAD/FIS1/BCLAF1/RPS3/PEA15 21 GO:0033674 positive regulation of kinase activity 52/1165 467/18722 3.35012908181743e-05 0.000817577153749619 EGFR/MET/MAGED1/DAG1/EPHB4/LMO4/PRKCZ/HSP90AB1/ERBB3/CD24/FERMT2/FLT1/IGF1R/PRLR/EFNA1/NCF1/CCND3/NPM1/HSP90AA1/DLG1/HLA-DRB1/RHOA/VEGFA/PTPRC/VAV3/CD86/CCND1/ATP2B4/CD74/CIB1/SLC11A1/RAD50/TGFB1/CKS2/TREM2/PARK7/HRAS/IGF2/PHB/BAD/PPIA/S100A12/FGR/CKS1B/ERP29/RPS3/SYK/ADAM8/CD300A/JAK2/CCNB1/LYN 52 GO:0002449 lymphocyte mediated immunity 42/1165 350/18722 3.40589532024524e-05 0.000827588330412837 HLA-B/HLA-A/B2M/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/FCER1G/HLA-DPA1/TUBB4B/HLA-DRA/CTSH/PRDX1/HLA-F/C1QA/TUBB/C1QB/C1QC/HLA-DRB1/HLA-DPB1/PTPRC/IL4I1/C1QBP/CD55/CD46/CD74/PTPN6/TGFB1/TREM2/LILRB4/IRF7/RSAD2/MYO1G/HLA-DMA/HLA-DQA1/LILRB1/GAPT/HLA-DQA2/HLA-DMB/TNFRSF1B 42 GO:0034109 homotypic cell-cell adhesion 17/1165 90/18722 3.4615920932445e-05 0.000829458990891155 DSP/DSG2/ANK3/DSC2/PLPP3/GNAS/FLNA/PLAUR/CD9/IL6ST/PTPN6/JAK1/PPIA/ACTB/SYK/JAK2/LYN 17 GO:0070664 negative regulation of leukocyte proliferation 17/1165 90/18722 3.4615920932445e-05 0.000829458990891155 DLG5/TYROBP/PAWR/CEBPB/DLG1/HLA-DRB1/LST1/IL4I1/GSTP1/CD86/PTPN6/LILRB2/LILRB4/MNDA/LILRB1/CD300A/LYN 17 GO:0045580 regulation of T cell differentiation 23/1165 146/18722 3.47164464730231e-05 0.000829458990891155 GATA3/PRKCZ/GLI3/SOD1/PRDX2/HLA-DRA/FGL2/HLA-DRB1/RHOA/PTPRC/IL4I1/SOX4/CD86/IRF1/CD46/CD74/LILRB2/LILRB4/BAD/SYK/ADAM8/PNP/CD83 23 GO:0034446 substrate adhesion-dependent cell spreading 19/1165 108/18722 3.47270377444186e-05 0.000829458990891155 LAMA5/KANK1/LAMB1/FBLN1/LAMC1/TACSTD2/FERMT2/EFNA1/S100A10/NRP1/P4HB/GBP1/RHOA/C1QBP/FLNA/CIB1/LIMS1/TRIOBP/CALR 19 GO:0016055 Wnt signaling pathway 50/1165 444/18722 3.51963365169019e-05 0.000837106088429535 EGFR/KANK1/LGR5/WLS/LGR4/LRP5/FERMT1/RNF43/ISL1/ZNRF3/APP/FOLR1/GATA3/GLI3/ATP6V1C2/ASPM/NOTUM/GPC3/DDB1/CD24/FERMT2/PLPP3/YAP1/APOE/TBL1X/DLX5/VCP/DAB2/SIAH2/RHOA/CCNE1/SOX4/LATS2/RPS12/PFDN5/CCND1/KLF4/RUVBL1/BRD7/TGFB1/RNF213/RTF1/USP47/TLE4/TLR2/MBD2/SULF2/SNX3/LRP1/ZEB2 50 GO:0050727 regulation of inflammatory response 45/1165 386/18722 3.71086213233773e-05 0.000878863677165049 EGFR/ISL1/SERPINF1/APP/GATA3/TMSB4X/HSPD1/SOD1/PTGES/HLA-E/NCF1/NFKBIA/BRD4/MGLL/APOE/YES1/PDCD4/ZFP36/CEBPB/GPX1/S100A8/HLA-DRB1/TGM2/PTPRC/GSTP1/KLF4/IL6ST/PYCARD/GPX4/TREM2/PARK7/GPSM3/HCK/UFL1/S100A12/FGR/TLR2/SOCS3/SYK/ADAM8/JAK2/TNFRSF1B/PSMB4/GRN/LYN 45 GO:0050714 positive regulation of protein secretion 22/1165 137/18722 3.77594015456952e-05 0.000890518995277256 EGFR/MYH10/WLS/GJA1/ISL1/EXPH5/FRMD4A/KCNN4/MPC2/HLA-DRB1/SOX4/SERP1/TGFB1/TREM2/BAD/PPIA/TLR2/GLUL/CD2AP/ADAM8/LRP1/JAK2 22 GO:0071346 cellular response to interferon-gamma 20/1165 118/18722 3.81135288748762e-05 0.000895109780647197 ASS1/HSP90AB1/GAPDH/HLA-DPA1/GBP2/IFNGR2/AIF1/STAT1/GBP1/GBP4/CCL3L3/VIM/IRF1/GBP5/HCK/JAK1/TLR2/CCL4/PARP9/JAK2 20 GO:0002262 myeloid cell homeostasis 24/1165 157/18722 3.91725667254089e-05 0.0009161484042905 TGFBR3/JAM3/B2M/GATA3/ISG15/RPS17/CDK6/SOD1/EPAS1/KLF2/PRDX1/ZFP36/STAT1/PRKDC/VEGFA/SLC25A5/FAM210B/SPI1/RPS14/UFL1/ZFP36L1/PRMT1/JAK2/LYN 24 GO:0097191 extrinsic apoptotic signaling pathway 30/1165 219/18722 3.9523028725726e-05 0.000916596852029425 KRT18/ITGA6/KRT8/TIMP3/ERBB3/YAP1/NRP1/PRDX2/ITM2C/TNFRSF12A/GCLM/PMAIP1/GPX1/SIAH2/PTPRC/IFI6/GSTP1/LGALS3/SKIL/SPI1/TNFSF10/CIB1/PYCARD/TGFB1/PARK7/BCL2A1/BAD/PEA15/JAK2/TNFRSF1B 30 GO:0198738 cell-cell signaling by wnt 50/1165 446/18722 3.95674296840856e-05 0.000916596852029425 EGFR/KANK1/LGR5/WLS/LGR4/LRP5/FERMT1/RNF43/ISL1/ZNRF3/APP/FOLR1/GATA3/GLI3/ATP6V1C2/ASPM/NOTUM/GPC3/DDB1/CD24/FERMT2/PLPP3/YAP1/APOE/TBL1X/DLX5/VCP/DAB2/SIAH2/RHOA/CCNE1/SOX4/LATS2/RPS12/PFDN5/CCND1/KLF4/RUVBL1/BRD7/TGFB1/RNF213/RTF1/USP47/TLE4/TLR2/MBD2/SULF2/SNX3/LRP1/ZEB2 50 GO:0061450 trophoblast cell migration 7/1165 17/18722 3.96816381690985e-05 0.000916596852029425 ITGB4/GJA1/TIMP1/VEGFA/C1QBP/ARHGDIB/CALR 7 GO:0030595 leukocyte chemotaxis 31/1165 230/18722 4.06253126522841e-05 0.000934548688185536 DPP4/JAM3/CXCR4/FLT1/FCER1G/AIF1/DUSP1/BSG/PTN/LGMN/S100A8/PPIB/VEGFA/VAV3/C1QBP/CCL3L3/LGALS3/SPI1/TREM1/CD74/GPSM3/CALR/CSF3R/PPIA/S100A12/CXCL10/CXCL16/CCL4/SYK/ADAM8/LYN 31 GO:0001906 cell killing 27/1165 188/18722 4.1232119574953e-05 0.000944636274180453 HLA-B/LYZ/HLA-A/B2M/TYROBP/CADM1/HSP90AB1/HLA-E/CD59/GAPDH/STXBP2/TUBB4B/HLA-DRA/CTSH/PRDX1/HLA-F/TUBB/HLA-DRB1/PTPRC/CD55/SPI1/TREM1/PTPN6/S100A12/LILRB1/ROMO1/SYK 27 GO:0002833 positive regulation of response to biotic stimulus 25/1165 168/18722 4.31988515680951e-05 0.000985671357120804 TYROBP/CADM1/HSPD1/CYBA/HLA-E/FCN1/HSP90AA1/HLA-F/HLA-DRB1/PRKDC/SPI1/PLSCR1/PYCARD/GBP5/IRF7/HCK/OASL/MNDA/IFI16/PARP9/SYK/ADAM8/LILRA2/GRN/LYN 25 GO:0006909 phagocytosis 38/1165 308/18722 4.34134601351606e-05 0.000986557699346787 MET/COLEC12/TYROBP/SYT7/SOD1/CYBA/FCN1/FCER1G/ANXA3/NCF2/AIF1/MYO7A/YES1/ITGB1/CD14/PECAM1/TGM2/PTPRC/VAV3/EIF2AK1/PLSCR1/RHOBTB1/PYCARD/SLC11A1/TREM2/HCK/MYO1G/CALR/FGR/TLR2/RHOG/CLN3/ICAM3/SNX3/SYK/LRP1/CD300A/LYN 38 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 9/1165 29/18722 4.36266862055242e-05 0.000987405603514547 YES1/GPX1/HLA-DRB1/TREM2/HCK/FGR/SYK/PSMB4/LYN 9 GO:0048732 gland development 49/1165 436/18722 4.42298575651413e-05 0.000997036909691318 CDH1/LAMA5/EGFR/MET/TGFBR3/PBX1/BMP7/WLS/KRT18/LRP5/DAG1/LSR/ISL1/TFCP2L1/SERPINF1/LMO4/GATA3/GLI3/SOD1/ASS1/ARID5B/TBX3/PRLR/NRP1/PRDX2/PTN/IRF6/CDO1/CEBPB/GPX1/PRKDC/TGM2/VEGFA/CRIP1/CCND1/MSN/TGFB1/SLC29A1/HRAS/OAS2/IGF2/RPS16/TYMS/ACO2/NME1/TSPO/CGA/SULF2/JAK2 49 GO:0032481 positive regulation of type I interferon production 13/1165 58/18722 4.47170483511632e-05 0.000999987220697525 ISG15/HSPD1/GAPDH/HSP90AA1/STAT1/CD14/DHX36/IRF1/IRF7/OAS1/OAS2/TLR2/SYK 13 GO:0042743 hydrogen peroxide metabolic process 13/1165 58/18722 4.47170483511632e-05 0.000999987220697525 EGFR/SOD2/PRDX4/SOD1/CYBA/PRDX2/PRDX1/PRDX5/GPX1/PRDX3/PARK7/PRDX6/GPX3 13 GO:0050672 negative regulation of lymphocyte proliferation 16/1165 83/18722 4.5057311454711e-05 0.00100359797299719 DLG5/TYROBP/PAWR/CEBPB/DLG1/HLA-DRB1/LST1/IL4I1/CD86/PTPN6/LILRB2/LILRB4/MNDA/LILRB1/CD300A/LYN 16 GO:0002861 regulation of inflammatory response to antigenic stimulus 11/1165 43/18722 4.68489546155042e-05 0.00103785289506982 HLA-E/YES1/GPX1/HLA-DRB1/TREM2/PARK7/HCK/FGR/SYK/PSMB4/LYN 11 GO:0010810 regulation of cell-substrate adhesion 30/1165 221/18722 4.69650160961577e-05 0.00103785289506982 KANK1/CCDC80/FBLN1/ITGA6/DAG1/FERMT1/TACSTD2/PRKCZ/CDK6/RASA1/FERMT2/S100A10/NRP1/SLC9A1/P4HB/PTN/GBP1/RHOA/VEGFA/C1QBP/FLNA/CIB1/LIMS1/TRIOBP/CALR/PTPRA/RRAS/UTRN/LRP1/JAK2 30 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 42/1165 355/18722 4.74454374651952e-05 0.00104435780585153 FBN1/LRP2/FBN2/CRIM1/TGFBR3/BMP7/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/PARP1/FSTL1/HSP90AB1/GPC3/ITGB5/FERMT2/ITGB8/RBPMS/NREP/PDCD4/ID1/DLX5/FUT8/HSPA5/DAB2/FOS/HTRA1/HPGD/LATS2/VIM/SKIL/SPI1/EID2/TGFB1/GDF15/SNX6/JUN/LRP1/ZEB2/SORL1/JAK2 42 GO:0090322 regulation of superoxide metabolic process 10/1165 36/18722 4.79809953938695e-05 0.00105202080916324 EGFR/BMP7/TYROBP/SOD1/CYBA/GSTP1/TGFB1/GNAI2/GCH1/SYK 10 GO:0002761 regulation of myeloid leukocyte differentiation 20/1165 120/18722 4.88332465543862e-05 0.00106187692131731 FBN1/TYROBP/CDK6/CEBPB/C1QC/FOS/HLA-DRB1/EVI2B/ESRRA/CD74/TGFB1/TREM2/LILRB4/IRF7/LILRB1/NME1/ZFP36L1/LILRB3/JUN/LYN 20 GO:0030218 erythrocyte differentiation 20/1165 120/18722 4.88332465543862e-05 0.00106187692131731 TGFBR3/B2M/GATA3/ISG15/CDK6/EPAS1/KLF2/ZFP36/STAT1/PRKDC/VEGFA/SLC25A5/FAM210B/SPI1/RPS14/UFL1/ZFP36L1/PRMT1/JAK2/LYN 20 GO:0043434 response to peptide hormone 47/1165 414/18722 4.89980621095999e-05 0.00106187692131731 FBN1/KANK1/TGFBR3/BMP7/LRP5/DAG1/SLC2A1/GJA1/SORBS1/TIMP1/PRKCZ/PARP1/CYBA/ASS1/CYBB/IGF1R/GGH/GNAI1/SLC9A1/CCND3/BSG/STAT1/ATP2B1/CDO1/FOXO4/PRKDC/GSTP1/GRB2/PIK3C2A/ESRRA/TNFSF10/NUCKS1/MDM2/PKM/GDF15/RETN/IGF2/PTPRA/TLR2/GNAI2/APEX1/ZFP36L1/SOCS3/SORL1/JAK2/LYN/NR4A1 47 GO:0050878 regulation of body fluid levels 44/1165 379/18722 4.98151510636297e-05 0.00107543247276982 F5/EGFR/MET/FBLN1/GJA5/CLDN4/LSR/GJA1/SERPINA1/ATP6V1B1/LMAN1/CYBA/FCER1G/CD59/PRLR/KCNN4/PRDX2/APOE/AKR1B1/GNAS/CDO1/VEGFA/PRKACB/VAV3/FLNA/PLAUR/CD9/PLSCR1/CCND1/IL6ST/AK3/PTPN6/SLC29A1/ST3GAL4/STMN1/OAS2/PPIA/GNAI2/NME1/ACTB/SYK/JAK2/TFPI2/LYN 44 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 42/1165 356/18722 5.06402862776573e-05 0.00108905719109766 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/CTSH/HLA-F/C1QA/C1QB/C1QC/HLA-DRB1/HLA-DPB1/PTPRC/IL4I1/C1QBP/CD55/CD46/CD74/SLC11A1/PTPN6/TNFSF13B/TGFB1/TREM2/LILRB4/IRF7/RSAD2/MYO1G/HRAS/PHB/HLA-DMA/HLA-DQA1/LILRB1/GAPT/HLA-DQA2/HLA-DMB/TNFRSF1B 42 GO:0048660 regulation of smooth muscle cell proliferation 26/1165 180/18722 5.14571876004137e-05 0.00110240150382108 EGFR/ADAMTS1/GJA1/SOD2/CYBA/AIF1/APOE/PDCD4/COMT/STAT1/DNMT1/AKR1B1/SKP2/PRKDC/RHOA/TGM2/HPGD/GSTP1/KLF4/TGFB1/MDM2/PHB/GNAI2/SF1/JUN/JAK2 26 GO:0032945 negative regulation of mononuclear cell proliferation 16/1165 84/18722 5.24879232304805e-05 0.00111946948840927 DLG5/TYROBP/PAWR/CEBPB/DLG1/HLA-DRB1/LST1/IL4I1/CD86/PTPN6/LILRB2/LILRB4/MNDA/LILRB1/CD300A/LYN 16 GO:0046635 positive regulation of alpha-beta T cell activation 14/1165 67/18722 5.27831938292742e-05 0.00111946948840927 HLA-A/PRKCZ/GLI3/HLA-E/HLA-DRA/HLA-DRB1/RHOA/PTPRC/CD55/CD86/LILRB4/SYK/PNP/CD83 14 GO:0030177 positive regulation of Wnt signaling pathway 22/1165 140/18722 5.29752061962811e-05 0.00111946948840927 EGFR/KANK1/LGR5/WLS/LGR4/ATP6V1C2/ASPM/GPC3/YAP1/TBL1X/DLX5/VCP/DAB2/SOX4/RPS12/RUVBL1/TGFB1/USP47/TLR2/MBD2/SULF2/ZEB2 22 GO:1903362 regulation of cellular protein catabolic process 33/1165 255/18722 5.30516450947559e-05 0.00111946948840927 LRP2/LAPTM5/HSP90AB1/EFNA1/RPL23/APOE/HSP90AA1/PSMD14/MAGEF1/PSME2/GPX1/VCP/DAB2/BAG2/UBB/PITHD1/PSMC1/PSMC3/MYLIP/PSMC6/RPL5/MSN/MDM2/TREM2/USP14/PARK7/RAD23B/RPS7/PSMC4/UFL1/PSME1/LRP1/ATRAID 33 GO:0051591 response to cAMP 17/1165 93/18722 5.35572559425952e-05 0.00112590590863591 LDHA/APP/ASS1/DUSP1/BSG/STAT1/CDO1/HSPA5/FOS/AKAP9/FDX1/NME1/APEX1/ZFP36L1/SLC8A1/JUN/AQP9 17 GO:0010631 epithelial cell migration 42/1165 357/18722 5.40301949933978e-05 0.00113080460153828 KANK1/MET/NR2F2/DPP4/EPHB4/FERMT1/TACSTD2/SERPINF1/NRP2/GATA3/TMSB4X/AMOT/S100P/FSTL1/MARVELD3/ANXA3/PLPP3/EFNA1/NRP1/APOE/CTSH/ITGB1/PTN/ID1/GPX1/LGMN/RHOA/VEGFA/RAB25/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/RAB11A/PDCD6/ZEB2/GRN/NR4A1 42 GO:0043523 regulation of neuron apoptotic process 29/1165 212/18722 5.4193201107037e-05 0.00113080460153828 ISL1/TYROBP/SOD2/GATA3/TFAP2A/HSPD1/PARP1/SOD1/HSP90AB1/ERBB3/RASA1/NRP1/APOE/GCLM/CEBPB/LGMN/RHOA/TREM2/PARK7/HRAS/SET/SNX6/FIS1/CLN3/JUN/ADAM8/LRP1/JAK2/GRN 29 GO:2000379 positive regulation of reactive oxygen species metabolic process 15/1165 76/18722 5.81484173091775e-05 0.00120884098650523 EGFR/TYROBP/SOD2/SOD1/CYBA/SLC5A3/GSTP1/DCXR/GRB2/TGFB1/PARK7/GNAI2/ROMO1/TSPO/SYK 15 GO:0042554 superoxide anion generation 11/1165 44/18722 5.89820681630613e-05 0.00122164704280171 EGFR/TYROBP/SOD1/CYBA/CYBB/NCF2/NCF1/GSTP1/TGFB1/GNAI2/SYK 11 GO:0036294 cellular response to decreased oxygen levels 24/1165 161/18722 5.92562606601696e-05 0.00122281393781446 BMP7/EPAS1/CYBB/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/ERO1A/BAD/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 24 GO:0030593 neutrophil chemotaxis 18/1165 103/18722 6.06134269018645e-05 0.00124623870036691 DPP4/JAM3/FCER1G/BSG/S100A8/PPIB/VAV3/C1QBP/CCL3L3/LGALS3/TREM1/CD74/CSF3R/PPIA/S100A12/CXCL10/CCL4/SYK 18 GO:0002283 neutrophil activation involved in immune response 7/1165 18/18722 6.14497741703571e-05 0.00125882329349713 TYROBP/FCER1G/ANXA3/STXBP2/SPI1/SYK/LILRA2 7 GO:0032570 response to progesterone 10/1165 37/18722 6.21104489568064e-05 0.00126773072725293 CLDN4/YAP1/PTN/FOS/TGFB1/TXNIP/BAD/TYMS/TLR2/TSPO 10 GO:0031102 neuron projection regeneration 13/1165 60/18722 6.51995991272678e-05 0.00132596141268606 DAG1/JAM3/ISL1/FOLR1/NREP/PTN/FLNA/MTR/KLF4/TSPO/LRP1/JAK2/GRN 13 GO:0090132 epithelium migration 42/1165 360/18722 6.54786279453995e-05 0.00132682865941346 KANK1/MET/NR2F2/DPP4/EPHB4/FERMT1/TACSTD2/SERPINF1/NRP2/GATA3/TMSB4X/AMOT/S100P/FSTL1/MARVELD3/ANXA3/PLPP3/EFNA1/NRP1/APOE/CTSH/ITGB1/PTN/ID1/GPX1/LGMN/RHOA/VEGFA/RAB25/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/RAB11A/PDCD6/ZEB2/GRN/NR4A1 42 GO:0032928 regulation of superoxide anion generation 8/1165 24/18722 6.57560217303906e-05 0.00132765665457799 EGFR/TYROBP/SOD1/CYBA/GSTP1/TGFB1/GNAI2/SYK 8 GO:0031348 negative regulation of defense response 33/1165 258/18722 6.69052749273047e-05 0.00134601902568803 HLA-B/HLA-A/ISL1/SERPINF1/GATA3/ISG15/SOD1/HLA-E/FGL2/APOE/YES1/ZFP36/HLA-F/GPX1/HLA-DRB1/HTRA1/PTPRC/C1QBP/GSTP1/A2M/KLF4/TREM2/OAS1/HCK/FGR/LILRB1/IFI16/SOCS3/SYK/TNFRSF1B/PSMB4/GRN/LYN 33 GO:0046634 regulation of alpha-beta T cell activation 18/1165 104/18722 6.9104127775605e-05 0.00138036110037178 HLA-A/GATA3/PRKCZ/GLI3/HLA-E/HLA-DRA/HLA-DRB1/RHOA/PTPRC/CD55/CD86/IRF1/LILRB4/LILRB1/SYK/PNP/CD83/CD300A 18 GO:1903076 regulation of protein localization to plasma membrane 18/1165 104/18722 6.9104127775605e-05 0.00138036110037178 EGFR/SORBS1/ITGB1/DLG1/GBP1/DAB2/LGALS3/CLTC/ATP2B4/CIB1/TGFB1/TREM2/RHOG/ACTB/CLN3/ABI3/RAB11A/LRP1 18 GO:2000117 negative regulation of cysteine-type endopeptidase activity 16/1165 86/18722 7.06479766064832e-05 0.0014061953641567 CD44/DHCR24/PRDX5/GPX1/SIAH2/VEGFA/IFI6/PLAUR/KLF4/MDM2/PRDX3/PARK7/USP47/IFI16/LAMTOR5/NR4A1 16 GO:0048659 smooth muscle cell proliferation 26/1165 184/18722 7.49359115932577e-05 0.00148627304513412 EGFR/ADAMTS1/GJA1/SOD2/CYBA/AIF1/APOE/PDCD4/COMT/STAT1/DNMT1/AKR1B1/SKP2/PRKDC/RHOA/TGM2/HPGD/GSTP1/KLF4/TGFB1/MDM2/PHB/GNAI2/SF1/JUN/JAK2 26 GO:0042255 ribosome assembly 13/1165 61/18722 7.81917520787051e-05 0.00154177774308294 RPSA/RPS27/NPM1/RPLP0/PRKDC/C1QBP/RPS28/RPS5/MRPL20/RPS14/RPL5/BRIX1/MRPS7 13 GO:0030111 regulation of Wnt signaling pathway 39/1165 328/18722 7.82837443040509e-05 0.00154177774308294 EGFR/KANK1/LGR5/WLS/LGR4/FERMT1/RNF43/ISL1/ZNRF3/APP/FOLR1/GLI3/ATP6V1C2/ASPM/NOTUM/GPC3/PLPP3/YAP1/APOE/TBL1X/DLX5/VCP/DAB2/SIAH2/SOX4/LATS2/RPS12/PFDN5/RUVBL1/TGFB1/RNF213/USP47/TLE4/TLR2/MBD2/SULF2/SNX3/LRP1/ZEB2 39 GO:0007566 embryo implantation 12/1165 53/18722 7.85839194051911e-05 0.00154227811056412 FBLN1/ITGB4/GJA1/TIMP1/SOD1/PRLR/BSG/VEGFA/C1QBP/ARHGDIB/CALR/VMP1 12 GO:0051098 regulation of binding 42/1165 363/18722 7.90943757374271e-05 0.00154688756450933 MET/TGFBR3/ISL1/B2M/PHLDA2/APP/GATA3/TMSB4X/PARP1/HSP90AB1/MSX2/S100A10/NRP1/NFKBIA/APOE/ID1/DAB2/BAG2/LRPAP1/C4orf3/IFIT2/PLAUR/RAN/KLF4/NUCKS1/TGFB1/PARK7/STMN1/HDAC2/IFIT1/ZNF593/NME1/IFI16/GMNN/ACTB/LAMTOR5/MBD2/JUN/PARP9/LRP1/SORL1/JAK2 42 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/1165 78/18722 7.95494863798813e-05 0.00155038634392456 CD44/DHCR24/PRDX5/GPX1/SIAH2/VEGFA/IFI6/PLAUR/KLF4/MDM2/PRDX3/PARK7/USP47/LAMTOR5/NR4A1 15 GO:0002705 positive regulation of leukocyte mediated immunity 21/1165 134/18722 8.08741685866992e-05 0.00156469398972281 HLA-B/HLA-A/B2M/TYROBP/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/DHX36/SPI1/DDX1/TGFB1/TREM2/RSAD2 21 GO:0002718 regulation of cytokine production involved in immune response 17/1165 96/18722 8.11198915035341e-05 0.00156469398972281 HLA-A/B2M/GATA3/PRKCZ/LAPTM5/HLA-E/HLA-F/CD55/DHX36/DDX1/CD74/TGFB1/LILRB4/RSAD2/LILRB1/BST2/TNFRSF1B 17 GO:0010769 regulation of cell morphogenesis involved in differentiation 17/1165 96/18722 8.11198915035341e-05 0.00156469398972281 KANK1/FBLN1/TACSTD2/OBSL1/FERMT2/S100A10/NRP1/P4HB/GBP1/PRKDC/C1QBP/FLNA/DHX36/CIB1/LIMS1/TRIOBP/CALR 17 GO:0150104 transport across blood-brain barrier 16/1165 87/18722 8.16407727196076e-05 0.00156934814135328 LRP2/SLC2A1/SLC16A12/SLC38A1/SLC19A1/TFRC/SLC13A3/SLC5A3/APOE/SLC5A6/ATP2B4/SLC1A3/SLC29A1/SLC2A3/SLCO2B1/LRP1 16 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 14/1165 70/18722 8.75303587197028e-05 0.00167681878325492 B2M/HSPD1/TFRC/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DPB1/PTPRC/TGFB1/HLA-DMA/HLA-DQA1/GAPT/HLA-DQA2/HLA-DMB 14 GO:0090263 positive regulation of canonical Wnt signaling pathway 18/1165 106/18722 8.92929278962278e-05 0.00170388906317119 EGFR/KANK1/LGR5/WLS/LGR4/ASPM/GPC3/YAP1/TBL1X/DLX5/VCP/SOX4/RPS12/RUVBL1/TGFB1/USP47/SULF2/ZEB2 18 GO:0090130 tissue migration 42/1165 365/18722 8.95505565001782e-05 0.00170388906317119 KANK1/MET/NR2F2/DPP4/EPHB4/FERMT1/TACSTD2/SERPINF1/NRP2/GATA3/TMSB4X/AMOT/S100P/FSTL1/MARVELD3/ANXA3/PLPP3/EFNA1/NRP1/APOE/CTSH/ITGB1/PTN/ID1/GPX1/LGMN/RHOA/VEGFA/RAB25/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/RAB11A/PDCD6/ZEB2/GRN/NR4A1 42 GO:0043524 negative regulation of neuron apoptotic process 22/1165 145/18722 9.07570898600827e-05 0.00172101197765083 ISL1/SOD2/HSPD1/SOD1/HSP90AB1/ERBB3/RASA1/NRP1/APOE/GCLM/CEBPB/LGMN/RHOA/PARK7/HRAS/SET/SNX6/CLN3/ADAM8/LRP1/JAK2/GRN 22 GO:0000028 ribosomal small subunit assembly 7/1165 19/18722 9.20804184933427e-05 0.00174022689900045 RPSA/RPS27/PRKDC/RPS28/RPS5/RPS14/MRPS7 7 GO:0032613 interleukin-10 production 13/1165 62/18722 9.33671926927434e-05 0.00175274265078384 TYROBP/ISG15/PRKCZ/HSPD1/HLA-DRB1/CD46/PYCARD/TREM2/LILRB4/TLR2/LILRB1/SYK/CD83 13 GO:0032653 regulation of interleukin-10 production 13/1165 62/18722 9.33671926927434e-05 0.00175274265078384 TYROBP/ISG15/PRKCZ/HSPD1/HLA-DRB1/CD46/PYCARD/TREM2/LILRB4/TLR2/LILRB1/SYK/CD83 13 GO:1901215 negative regulation of neuron death 28/1165 208/18722 9.60578491750568e-05 0.00179724235806531 ISL1/SOD2/SERPINF1/HSPD1/SOD1/HSP90AB1/ERBB3/RASA1/NRP1/APOE/GCLM/HLA-F/CEBPB/LGMN/RHOA/PSMC1/PARK7/HRAS/NENF/SET/SNX6/CLN3/ADAM8/LRP1/SORL1/JAK2/TNFRSF1B/GRN 28 GO:0002347 response to tumor cell 10/1165 39/18722 0.000101161673820469 0.00187492078310638 HLA-A/HSPD1/LAPTM5/PRDX2/HLA-DRB1/IL4I1/SPI1/KLF4/TXNIP/ABI3 10 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 18/1165 107/18722 0.00010121165103888 0.00187492078310638 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/SLC11A1/TNFSF13B/TGFB1/TREM2/RSAD2 18 GO:0008637 apoptotic mitochondrial changes 18/1165 107/18722 0.00010121165103888 0.00187492078310638 SOD2/HSPD1/GGCT/BNIP3L/GCLM/PMAIP1/GPX1/SLC25A5/IFI6/IFIT2/PLAUR/TNFSF10/PYCARD/NMT1/BAD/FIS1/BNIP3/JUN 18 GO:0060326 cell chemotaxis 37/1165 310/18722 0.000109242052664977 0.00201702513687011 MET/DPP4/JAM3/CXCR4/TMSB4X/FLT1/FCER1G/NRP1/AIF1/DUSP1/BSG/PTN/LGMN/S100A8/PPIB/VEGFA/VAV3/C1QBP/CCL3L3/GSTP1/LGALS3/SPI1/TREM1/CD74/GPSM3/CALR/CSF3R/PPIA/S100A12/CXCL10/CXCL16/CCL4/RHOG/SYK/ADAM8/LYN/NR4A1 37 GO:0045837 negative regulation of membrane potential 6/1165 14/18722 0.000111541291893149 0.0020527254799877 BNIP3L/PTN/PMAIP1/HEBP2/ARL6IP5/BNIP3 6 GO:0045471 response to ethanol 21/1165 137/18722 0.000111975517827938 0.00205398229270659 SOD2/GATA3/SOD1/CYBB/GGH/PSMD14/CDO1/S100A8/CD14/RHOA/HPGD/GSTP1/EPS8/DNMT3A/SPI1/CCND1/HDAC2/BAD/TYMS/RPL10A/RGS19 21 GO:0045646 regulation of erythrocyte differentiation 11/1165 47/18722 0.000112787376705429 0.00206213532719078 B2M/ISG15/CDK6/ZFP36/STAT1/PRKDC/FAM210B/SPI1/ZFP36L1/PRMT1/LYN 11 GO:0010498 proteasomal protein catabolic process 52/1165 490/18722 0.00011712631950404 0.00213232252135052 PSMB9/KLHL42/HSP90B1/HSP90AB1/DDB1/SIAH1/PSMB8/APOE/TBL1X/PSMD14/PSMD7/PSME2/PMAIP1/GPX1/SKP2/HSPA5/VCP/DAB2/BAG2/SIAH2/PSMD1/PSMB2/UBB/PITHD1/PSMC1/PSMB1/PSMC3/UBE4B/PSMB6/PSMB5/PSMC6/UBE2H/PSMA3/ANAPC11/MDM2/TREM2/USP14/PARK7/RAD23B/WWP1/CCDC47/CALR/PSMC4/PSMA1/UFL1/PSMB7/PSME1/PSMD2/CD2AP/PSMD6/UBXN4/PSMB4 52 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 24/1165 168/18722 0.000117386007321808 0.00213232252135052 HLA-B/HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/IL4I1/CD55/CD46/SLC11A1/PTPN6/TNFSF13B/TGFB1/TREM2/LILRB4/RSAD2/LILRB1/TNFRSF1B 24 GO:0110053 regulation of actin filament organization 34/1165 277/18722 0.000118808750135639 0.00215120488552046 KANK1/MET/TACSTD2/TMSB4X/KANK4/TJP1/RASA1/FERMT2/SCIN/TMSB10/DSTN/LIMA1/S100A10/NRP1/SLC9A1/COTL1/ID1/DLG1/RHOA/ARPC3/FLNA/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/STMN1/VASP/WASL/ADD3/IQGAP2 34 GO:0033627 cell adhesion mediated by integrin 14/1165 72/18722 0.000120483526618502 0.00216754498368477 FBN1/ITGB4/DPP4/FERMT1/JAM3/ITGB5/PLPP3/EFNA1/ITGB8/ITGB1/CIB1/PTPN6/SYK/LYN 14 GO:1903036 positive regulation of response to wounding 14/1165 72/18722 0.000120483526618502 0.00216754498368477 KANK1/CLDN4/FERMT1/CXCR4/FERMT2/PLPP3/PRDX2/ITGB1/PTN/FLNA/ST3GAL4/HRAS/LRP1/GRN 14 GO:0014074 response to purine-containing compound 22/1165 148/18722 0.000123530805468803 0.00220120130506792 SLC6A4/LDHA/APP/HSPD1/SOD1/HSP90B1/ASS1/DUSP1/BSG/STAT1/CDO1/HSPA5/FOS/AKAP9/FDX1/HDAC2/NME1/APEX1/ZFP36L1/SLC8A1/JUN/AQP9 22 GO:0097530 granulocyte migration 22/1165 148/18722 0.000123530805468803 0.00220120130506792 DPP4/JAM3/FCER1G/BSG/S100A8/PECAM1/PPIB/VAV3/C1QBP/CCL3L3/LGALS3/TREM1/CD74/CSF3R/PPIA/S100A12/CXCL10/CCL4/RHOG/SYK/ADAM8/CD300A 22 GO:2001056 positive regulation of cysteine-type endopeptidase activity 22/1165 148/18722 0.000123530805468803 0.00220120130506792 HSPD1/PERP/LAPTM5/HSPE1/CTSH/PMAIP1/LGMN/VCP/S100A8/RHOA/ASPH/TNFSF10/PYCARD/ARL6IP5/BAD/IFI16/FIS1/CYCS/RPS3/PDCD6/SYK/JAK2 22 GO:0006898 receptor-mediated endocytosis 31/1165 244/18722 0.000124369470219688 0.00220913239349084 LRP2/CTSL/B2M/AAK1/FOLR1/TFRC/FCER1G/APOE/AP1S1/ITGB1/FNBP1L/DAB2/CD14/LRPAP1/VEGFA/CLTA/CD9/GRB2/CLTC/APOC1/AP2A2/LILRB4/WASL/LILRB1/CXCL16/ASGR1/CLN3/CD2AP/SYK/LRP1/SORL1 31 GO:0071900 regulation of protein serine/threonine kinase activity 41/1165 359/18722 0.000127450054228173 0.0022567102661916 EGFR/NR2F2/MAGED1/BMP7/LRP5/CDKN1C/PKIB/HSP90AB1/CD24/FERMT2/FLT1/DUSP1/CCND3/APOE/PDCD4/RHOA/VEGFA/CCNE1/LATS2/GSTP1/CCND1/ATP2B4/CIB1/PYCARD/PTPN6/TGFB1/CKS2/HRAS/IGF2/S100A12/CKS1B/ACTB/SLC8A1/ERP29/RPS3/SYK/ADAM8/SORL1/CD300A/CCNB1/LYN 41 GO:0032507 maintenance of protein location in cell 13/1165 64/18722 0.000131486593660535 0.00232086242206472 SRGN/GJA1/TMSB4X/ANK3/SCIN/TMSB10/HSPA5/GPAA1/PARK7/KDELR1/TSPO/KDELR2/SORL1 13 GO:0032633 interleukin-4 production 9/1165 33/18722 0.000134052599140535 0.0023444586821918 GATA3/PRKCZ/HLA-E/FCER1G/CEBPB/HLA-DRB1/CD86/SYK/CD83 9 GO:0032673 regulation of interleukin-4 production 9/1165 33/18722 0.000134052599140535 0.0023444586821918 GATA3/PRKCZ/HLA-E/FCER1G/CEBPB/HLA-DRB1/CD86/SYK/CD83 9 GO:0002577 regulation of antigen processing and presentation 7/1165 20/18722 0.000134076471937211 0.0023444586821918 FGL2/CD74/PYCARD/SLC11A1/CD68/TREM2/LILRB2 7 GO:0043542 endothelial cell migration 34/1165 279/18722 0.000136697052352479 0.00238285886600765 MET/NR2F2/DPP4/EPHB4/SERPINF1/NRP2/GATA3/TMSB4X/AMOT/S100P/FSTL1/ANXA3/PLPP3/EFNA1/NRP1/APOE/ITGB1/PTN/ID1/GPX1/LGMN/RHOA/VEGFA/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/PDCD6/GRN/NR4A1 34 GO:0042274 ribosomal small subunit biogenesis 14/1165 73/18722 0.000140654372628474 0.00244425075406696 RPS17/RPS21/RPSA/RPS27/NPM1/PRKDC/SURF6/RPS28/RPS5/SNU13/RPS14/RPS7/RPS16/MRPS7 14 GO:0051651 maintenance of location in cell 28/1165 213/18722 0.000145163708164508 0.00251482683310921 FTH1/SRGN/GJA1/TMSB4X/ANK3/ASPM/CYBA/HSP90B1/SCIN/TMSB10/APOE/HSPA5/GPAA1/S100A8/PTPRC/AKAP9/PTPN6/GSTO1/PARK7/CALR/ERO1A/KDELR1/CXCL10/TSPO/KDELR2/SLC8A1/SORL1/LYN 28 GO:0002720 positive regulation of cytokine production involved in immune response 13/1165 65/18722 0.000155117484791238 0.00267899828348683 HLA-A/B2M/GATA3/PRKCZ/LAPTM5/HLA-E/HLA-F/CD55/DHX36/DDX1/CD74/RSAD2/LILRB1 13 GO:0007249 I-kappaB kinase/NF-kappaB signaling 34/1165 281/18722 0.000156970746348064 0.0027026895682567 WLS/GJA1/HACD3/PRDX4/TFRC/S100A4/GAPDH/NDFIP2/NFKBIA/BRD4/STAT1/HLA-DRB1/S100A13/RHOA/TGM2/SLC44A2/FLNA/GSTP1/TMED4/TFG/DHX36/DDX1/CD74/TNFSF10/PYCARD/TREM2/SECTM1/TRIM22/LILRB4/UFL1/S100A12/TLR2/BST2/LAMTOR5 34 GO:0010001 glial cell differentiation 29/1165 225/18722 0.000157817442411834 0.0027089581169958 EGFR/ITGB4/SPINT1/DAG1/CXCR4/APP/CDK6/GLI3/SOD1/GPC1/ERBB3/PTN/C1QA/S100A8/RHOA/SOX4/GSTP1/VIM/CD9/IL6ST/TGFB1/TREM2/HDAC2/TLR2/BNIP3/LRP1/TNFRSF1B/GRN/LYN 29 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 10/1165 41/18722 0.00015921940788502 0.00272469065993481 FERMT2/S100A10/NRP1/P4HB/C1QBP/FLNA/CIB1/LIMS1/TRIOBP/CALR 10 GO:0007565 female pregnancy 26/1165 193/18722 0.000165971964479552 0.00283161287727576 NR2F2/FBLN1/ITGB4/CTSV/CLDN4/SLC2A1/SLC38A1/GJA1/TIMP1/SLC19A1/SOD1/PRLR/COMT/BSG/PTN/AKR1B1/MAGED2/FOS/VEGFA/HPGD/C1QBP/JUNB/PRDX3/ARHGDIB/CALR/VMP1 26 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 8/1165 27/18722 0.000167896972738689 0.00283857140958512 YES1/PTPRC/VAV3/HCK/MYO1G/FGR/SYK/LYN 8 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 8/1165 27/18722 0.000167896972738689 0.00283857140958512 YES1/PTPRC/VAV3/HCK/MYO1G/FGR/SYK/LYN 8 GO:0060333 interferon-gamma-mediated signaling pathway 8/1165 27/18722 0.000167896972738689 0.00283857140958512 HSP90AB1/IFNGR2/STAT1/IRF1/HCK/JAK1/PARP9/JAK2 8 GO:0032355 response to estradiol 21/1165 141/18722 0.000169700374991173 0.00285188085277082 EGFR/NR2F2/BMP7/SLC6A4/GJA1/ASS1/DUSP1/PTN/HPGD/GSTP1/DNMT3A/FAM210B/CCND1/ESRRA/TGFB1/GPX4/TXNIP/NCOA3/CALR/BAD/MBD2 21 GO:1903038 negative regulation of leukocyte cell-cell adhesion 21/1165 141/18722 0.000169700374991173 0.00285188085277082 DLG5/GLI3/PAWR/LAPTM5/ASS1/PRDX2/FGL2/CEBPB/DLG1/HLA-DRB1/IL4I1/LGALS3/CD86/IRF1/KLF4/CD74/PTPN6/LILRB2/LILRB4/LILRB1/CD300A 21 GO:0045089 positive regulation of innate immune response 20/1165 131/18722 0.000170777307283975 0.00286141201726851 TYROBP/CADM1/HLA-E/FCN1/HSP90AA1/HLA-F/PRKDC/SPI1/PLSCR1/PYCARD/GBP5/IRF7/HCK/MNDA/IFI16/PARP9/SYK/ADAM8/LILRA2/LYN 20 GO:0002468 dendritic cell antigen processing and presentation 6/1165 15/18722 0.000176126619310816 0.00292484826683908 HLA-DRA/FGL2/HLA-DRB1/CD74/SLC11A1/CD68 6 GO:0098760 response to interleukin-7 6/1165 15/18722 0.000176126619310816 0.00292484826683908 HSPD1/LSP1/P4HB/ATIC/RAD23B/YBX1 6 GO:0098761 cellular response to interleukin-7 6/1165 15/18722 0.000176126619310816 0.00292484826683908 HSPD1/LSP1/P4HB/ATIC/RAD23B/YBX1 6 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 5/1165 10/18722 0.000179052734998271 0.00296466962107756 FGL2/LGALS3/APBB1IP/LILRB1/HLA-DMB 5 GO:0071826 ribonucleoprotein complex subunit organization 29/1165 227/18722 0.000184161741837508 0.0030402936968645 RPSA/HSP90AB1/RPS27/SNRPF/HSP90AA1/VCP/RPLP0/PRKDC/RPS28/RPS5/SNRPG/SNU13/DDX1/MRPL20/RUVBL1/RPS14/RPL5/EIF3A/BRIX1/EIF2S2/EIF5/SNRPD1/SNRPE/EIF3J/MRPS7/SNRPD2/SF1/SNRPD3/SNRPC 29 GO:0060993 kidney morphogenesis 16/1165 93/18722 0.000184724570958693 0.0030406422779799 LAMA5/MAGED1/PBX1/BMP7/LGR4/FRAS1/TACSTD2/GATA3/GLI3/IRX2/GPC3/STAT1/DLG1/VEGFA/SOX4/BASP1 16 GO:0050868 negative regulation of T cell activation 19/1165 122/18722 0.000188805235748186 0.00309872452706013 DLG5/GLI3/PAWR/LAPTM5/PRDX2/FGL2/CEBPB/DLG1/HLA-DRB1/IL4I1/LGALS3/CD86/IRF1/CD74/PTPN6/LILRB2/LILRB4/LILRB1/CD300A 19 GO:0030449 regulation of complement activation 7/1165 21/18722 0.000190356072409219 0.0031060134721888 CD59/C1QBP/CD55/A2M/CD46/TREM2/PHB 7 GO:0035455 response to interferon-alpha 7/1165 21/18722 0.000190356072409219 0.0031060134721888 IFITM3/GATA3/IFIT3/IFITM2/IFIT2/MX2/BST2 7 GO:0001954 positive regulation of cell-matrix adhesion 12/1165 58/18722 0.000196959203605219 0.00318597120990229 DAG1/FERMT1/PRKCZ/CDK6/FERMT2/S100A10/NRP1/VEGFA/CIB1/LIMS1/RRAS/UTRN 12 GO:0034340 response to type I interferon 12/1165 58/18722 0.000196959203605219 0.00318597120990229 IFITM3/ISG15/HSP90AB1/STAT1/IFITM2/MX1/PTPN6/IRF7/OAS1/JAK1/OAS2/IFIT1 12 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 12/1165 58/18722 0.000196959203605219 0.00318597120990229 SOD1/SIAH1/PMAIP1/S100A8/UBB/SKIL/PARK7/RPS7/BAD/FIS1/BCLAF1/RPS3 12 GO:0032760 positive regulation of tumor necrosis factor production 17/1165 103/18722 0.000198321057187735 0.00319483723798902 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/CD14/PTPRC/PYCARD/OAS1/HDAC2/OAS2/TLR2/SYK/JAK2/LILRA2 17 GO:0071214 cellular response to abiotic stimulus 38/1165 331/18722 0.000199214864296483 0.00319483723798902 EGFR/MME/DAG1/SLC2A1/ADIRF/GJA1/TMEM150C/GATA3/TIMP1/PARP1/CYBA/DDB1/YAP1/SLC9A1/NET1/NPM1/PTN/AKR1B1/GNA11/HSPA5/DHX36/GRB2/IRF1/EIF2AK4/CRIP1/NUCKS1/MDM2/OPN3/NMT1/HRAS/USP47/BAD/IFI16/CLN3/TSPO/BNIP3/ZFP36L1/MAP3K2 38 GO:0104004 cellular response to environmental stimulus 38/1165 331/18722 0.000199214864296483 0.00319483723798902 EGFR/MME/DAG1/SLC2A1/ADIRF/GJA1/TMEM150C/GATA3/TIMP1/PARP1/CYBA/DDB1/YAP1/SLC9A1/NET1/NPM1/PTN/AKR1B1/GNA11/HSPA5/DHX36/GRB2/IRF1/EIF2AK4/CRIP1/NUCKS1/MDM2/OPN3/NMT1/HRAS/USP47/BAD/IFI16/CLN3/TSPO/BNIP3/ZFP36L1/MAP3K2 38 GO:0071496 cellular response to external stimulus 37/1165 320/18722 0.000208386358811805 0.00333240066099903 EGFR/CTSV/DAG1/SLC2A1/GJA1/FOLR1/TMEM150C/CYBA/AIF1/SLC9A1/COMT/PTN/SESN1/ATP2B1/PMAIP1/SKP2/HSPA5/FOS/PTPRC/GSTP1/UPP1/IRF1/EIF2AK4/STK26/MDM2/CD68/TXN2/BAD/GLUL/ASGR1/IFI16/BNIP3/HSPA8/JUN/MAP3K2/GABARAPL1/LYN 37 GO:0051896 regulation of protein kinase B signaling 25/1165 185/18722 0.000209187331553892 0.00333570594321589 LRP2/EGFR/MET/DAG1/GATA3/HSP90AB1/FERMT2/IGF1R/PHLDA3/HSP90AA1/ITGB1/DLG1/GPX1/C1QBP/KLF4/CIB1/TGFB1/GDF15/PARK7/MYDGF/IGF2/PHB/RRAS/PDCD6/ADAM8 25 GO:0051702 biological process involved in interaction with symbiont 16/1165 94/18722 0.000209971170665866 0.00333872005934137 HSPD1/DDB1/GAPDH/APOE/GPX1/PPIB/PSMC3/TAF11/TREM1/EIF2AK4/NUCKS1/PHB/ROMO1/CCL4/HSPA8/JUN 16 GO:0035633 maintenance of blood-brain barrier 9/1165 35/18722 0.000219276174423092 0.00347682815547123 JAM3/LSR/GJA1/LAMC1/TJP1/ITGB1/PECAM1/VEGFA/ACTB 9 GO:0048661 positive regulation of smooth muscle cell proliferation 17/1165 104/18722 0.000223570342245277 0.00353493050992322 EGFR/ADAMTS1/GJA1/CYBA/AIF1/STAT1/DNMT1/AKR1B1/SKP2/TGM2/HPGD/TGFB1/MDM2/PHB/GNAI2/JUN/JAK2 17 GO:0071706 tumor necrosis factor superfamily cytokine production 25/1165 186/18722 0.000227702536607077 0.00358009618480539 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/ZFP36/CD14/PTPRC/GSTP1/CD86/PYCARD/PTPN6/TREM2/OAS1/HDAC2/OAS2/TLR2/LILRB1/TSPO/SYK/ADAM8/JAK2/LILRA2 25 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 25/1165 186/18722 0.000227702536607077 0.00358009618480539 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/ZFP36/CD14/PTPRC/GSTP1/CD86/PYCARD/PTPN6/TREM2/OAS1/HDAC2/OAS2/TLR2/LILRB1/TSPO/SYK/ADAM8/JAK2/LILRA2 25 GO:0001836 release of cytochrome c from mitochondria 12/1165 59/18722 0.000233428260622307 0.00365986823148886 SOD2/GGCT/PMAIP1/GPX1/IFI6/PLAUR/TNFSF10/PYCARD/BAD/FIS1/BNIP3/JUN 12 GO:0001909 leukocyte mediated cytotoxicity 19/1165 124/18722 0.000234383586981946 0.00366461023323025 HLA-B/HLA-A/B2M/TYROBP/CADM1/HLA-E/STXBP2/TUBB4B/HLA-DRA/CTSH/PRDX1/HLA-F/TUBB/HLA-DRB1/PTPRC/SPI1/TREM1/PTPN6/LILRB1 19 GO:0009743 response to carbohydrate 31/1165 253/18722 0.000240023280917511 0.00374236298830553 CTSV/KRT18/LRP5/LDHA/GJA1/COLEC12/SOD2/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/RHOA/SOX4/GSTP1/SLC29A1/TXNIP/TREM2/CCDC186/TXN2/BAD/GLUL/NME1/FIS1/ZFP36L1/SLC8A1/LRP1/ENSA/LYN 31 GO:0006458 'de novo' protein folding 10/1165 43/18722 0.000243069238559073 0.00377935633249883 HSPD1/HSPE1/ST13/HSPA5/DNAJB4/CCT2/CD74/ERO1A/SDF2/HSPA8 10 GO:0022618 ribonucleoprotein complex assembly 28/1165 220/18722 0.000251328544613544 0.0038862455121648 RPSA/HSP90AB1/RPS27/SNRPF/HSP90AA1/RPLP0/PRKDC/RPS28/RPS5/SNRPG/SNU13/DDX1/MRPL20/RUVBL1/RPS14/RPL5/EIF3A/BRIX1/EIF2S2/EIF5/SNRPD1/SNRPE/EIF3J/MRPS7/SNRPD2/SF1/SNRPD3/SNRPC 28 GO:0044706 multi-multicellular organism process 28/1165 220/18722 0.000251328544613544 0.0038862455121648 NR2F2/FBLN1/ITGB4/CTSV/CLDN4/SLC2A1/SLC6A4/SLC38A1/GJA1/TIMP1/SLC19A1/SOD1/PRLR/COMT/BSG/PTN/AKR1B1/MAGED2/FOS/VEGFA/HPGD/PITHD1/C1QBP/JUNB/PRDX3/ARHGDIB/CALR/VMP1 28 GO:0071453 cellular response to oxygen levels 24/1165 177/18722 0.000263653349596292 0.00406562156946151 BMP7/EPAS1/CYBB/HILPDA/SLC9A1/BNIP3L/P4HB/PTN/PMAIP1/VEGFA/DNMT3A/PGK1/MDM2/SLC29A1/TREM2/ENO1/ERO1A/BAD/BNIP3/ZFP36L1/SLC8A1/ADAM8/CCNB1/MALAT1 24 GO:0097202 activation of cysteine-type endopeptidase activity 6/1165 16/18722 0.000267002494025514 0.00409476775673555 PERP/LGMN/ASPH/PYCARD/BAD/IFI16 6 GO:1901163 regulation of trophoblast cell migration 6/1165 16/18722 0.000267002494025514 0.00409476775673555 GJA1/TIMP1/VEGFA/C1QBP/ARHGDIB/CALR 6 GO:0001503 ossification 44/1165 408/18722 0.000268694820042042 0.00410502298845022 FBN2/EGFR/CRIM1/SRGN/PBX1/SLC26A2/BMP7/LGR4/LRP5/SMOC1/RRBP1/ISG15/ATP6V1B1/TFAP2A/CDK6/GLI3/NOTUM/VCAN/GPC3/MSX2/FERMT2/HSPE1/YAP1/SNX10/PTN/ATP2B1/CEBPB/DLX5/RHOA/DHX36/CLTC/ESRRA/IL6ST/JUNB/TGFB1/CCDC47/IGF2/PHB/UFL1/SND1/FGR/SUCO/SLC8A1/ATRAID 44 GO:0006575 cellular modified amino acid metabolic process 25/1165 188/18722 0.000269133878451752 0.00410502298845022 CLIC3/ALDH7A1/FOLR1/GATA3/SLC19A1/SOD1/ASS1/CKMT1B/GGH/GSTA4/GCLM/IDH1/GPX1/SERINC2/GSTP1/PLSCR1/ATIC/ARL6IP5/GPX4/GSTO1/PARK7/AASDHPPT/TYMS/GCH1/CGA 25 GO:0002685 regulation of leukocyte migration 27/1165 210/18722 0.000272558829596201 0.00414599650548367 DPP4/JAM3/APP/AIF1/DUSP1/PTN/LGMN/RHOA/VEGFA/C1QBP/LGALS3/SPI1/CD9/CD74/PYCARD/MSN/ST3GAL4/TREM2/GPSM3/CALR/WASL/CXCL10/CCL4/RHOG/ADAM8/CD300A/LYN 27 GO:0042063 gliogenesis 35/1165 301/18722 0.000274286835832832 0.00416100543116131 LRP2/EGFR/ADGRG1/LAMB1/ITGB4/SPINT1/DAG1/CXCR4/APP/CDK6/GLI3/SOD1/GPC1/ERBB3/PTN/C1QA/S100A8/RHOA/SOX4/ETV5/GSTP1/VIM/CD9/IL6ST/TGFB1/TREM2/HDAC2/UFL1/TLR2/TSPO/BNIP3/LRP1/TNFRSF1B/GRN/LYN 35 GO:0030224 monocyte differentiation 9/1165 36/18722 0.000276374567432834 0.00417013561021639 CDK6/PIR/HLA-DRB1/VEGFA/CD74/IRF7/IFI16/ZFP36L1/JUN 9 GO:0042119 neutrophil activation 9/1165 36/18722 0.000276374567432834 0.00417013561021639 TYROBP/FCER1G/ANXA3/STXBP2/SPI1/SYK/CD300A/LILRA2/GRN 9 GO:0031960 response to corticosteroid 23/1165 167/18722 0.000278984824326991 0.00419823543953727 EGFR/CTSV/ISL1/SERPINF1/AGL/HSPD1/PARP1/CYBA/ASS1/CYBB/ANXA3/AIF1/DUSP1/ZFP36/ATP2B1/CDO1/FOS/RHOA/GSTP1/CCND1/BAD/TYMS/ZFP36L1 23 GO:0034504 protein localization to nucleus 34/1165 290/18722 0.00028569346315976 0.0042876936061918 CDH1/MAGED1/BMP7/FERMT1/PARP1/TFRC/GLI3/HSP90AB1/TRIM29/FERMT2/YAP1/GBP2/RPL23/NFKBIA/NPM1/LATS2/FLNA/CCT2/RAN/TGFB1/MDM2/TXNIP/PARK7/LILRB4/CALR/GLUL/TNPO1/YWHAE/LAMTOR5/PARP9/CD2AP/SYK/JAK2/NUP214 34 GO:0034605 cellular response to heat 13/1165 69/18722 0.000289735733672224 0.00431213175741238 HSPD1/HSP90AB1/RBBP7/HSP90AA1/VCP/DHX36/HSBP1L1/HDAC2/CXCL10/YWHAE/TFEC/PDCD6/LYN 13 GO:1904377 positive regulation of protein localization to cell periphery 13/1165 69/18722 0.000289735733672224 0.00431213175741238 EGFR/SORBS1/GNAI1/ITGB1/DLG1/LGALS3/ATP2B4/CIB1/TREM2/RHOG/CLN3/RAB11A/LRP1 13 GO:0001916 positive regulation of T cell mediated cytotoxicity 8/1165 29/18722 0.000290394762925687 0.00431213175741238 HLA-B/HLA-A/B2M/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC 8 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 8/1165 29/18722 0.000290394762925687 0.00431213175741238 SOD2/PARP1/SOD1/P4HB/GPX1/TREM2/PARK7/PPIA 8 GO:0051017 actin filament bundle assembly 22/1165 157/18722 0.000293106319137807 0.0043282255942672 MET/CALD1/TACSTD2/SORBS1/PAWR/HSP90B1/TJP1/ITGB5/FERMT2/PDLIM1/LIMA1/S100A10/NRP1/AIF1/SLC9A1/ID1/LCP1/RHOA/FLNA/EPS8/WASF2/STMN1 22 GO:0002218 activation of innate immune response 11/1165 52/18722 0.000293866445828428 0.0043282255942672 TYROBP/FCN1/HSP90AA1/PRKDC/PYCARD/HCK/MNDA/IFI16/SYK/LILRA2/LYN 11 GO:0071357 cellular response to type I interferon 11/1165 52/18722 0.000293866445828428 0.0043282255942672 IFITM3/ISG15/HSP90AB1/STAT1/IFITM2/PTPN6/IRF7/OAS1/JAK1/OAS2/IFIT1 11 GO:0045216 cell-cell junction organization 26/1165 200/18722 0.000294563010334949 0.0043282255942672 SVEP1/CDH1/GJA5/DSP/CLDN4/DSG2/JAM3/LSR/GJA1/DLG5/PERP/TJP1/MARVELD3/FERMT2/MPP7/PARD6B/CLDN7/DLG1/PECAM1/RHOA/VEGFA/FLNA/CD9/TGFB1/LIMS1/ACTB 26 GO:0051235 maintenance of location 37/1165 326/18722 0.000301087018614773 0.0044125363850776 FBN1/FBN2/FTH1/SRGN/GJA1/MEST/LTBP1/TMSB4X/ANK3/ASPM/CYBA/HSP90B1/SCIN/TMSB10/HILPDA/NFKBIA/APOE/HSPA5/GPAA1/S100A8/PTPRC/FLNA/PLIN2/AKAP9/PTPN6/GSTO1/TREM2/PARK7/CALR/ERO1A/KDELR1/CXCL10/TSPO/KDELR2/SLC8A1/SORL1/LYN 37 GO:0002706 regulation of lymphocyte mediated immunity 23/1165 168/18722 0.00030461774012781 0.00445265462327447 HLA-B/HLA-A/B2M/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/IL4I1/CD55/CD46/PTPN6/TGFB1/TREM2/LILRB4/RSAD2/LILRB1/TNFRSF1B 23 GO:0002357 defense response to tumor cell 5/1165 11/18722 0.000311440685667742 0.00452879940065553 LAPTM5/PRDX2/SPI1/KLF4/ABI3 5 GO:0034975 protein folding in endoplasmic reticulum 5/1165 11/18722 0.000311440685667742 0.00452879940065553 HSP90B1/P4HB/HSPA5/CALR/ERO1A 5 GO:0002274 myeloid leukocyte activation 28/1165 223/18722 0.000314850752515619 0.00456655626323041 TYROBP/APP/HSPD1/FCER1G/ANXA3/STXBP2/IFNGR2/ITGB8/AIF1/C1QA/S100A13/PTPRC/SPI1/PLSCR1/CD74/PYCARD/SLC11A1/TREM2/LILRB4/S100A12/FGR/TLR2/SYK/CD300A/JAK2/LILRA2/GRN/LYN 28 GO:0030217 T cell differentiation 31/1165 257/18722 0.000316913490458061 0.00458462737613685 CTSL/B2M/GATA3/PRKCZ/GLI3/SOD1/FCER1G/PRDX2/HLA-DRA/FGL2/HLA-DRB1/PRKDC/RHOA/PTPRC/IL4I1/SOX4/SPI1/CD86/IRF1/CD46/CD74/LILRB2/LILRB4/RSAD2/BAD/KDELR1/ZFP36L1/SYK/ADAM8/PNP/CD83 31 GO:0002702 positive regulation of production of molecular mediator of immune response 18/1165 117/18722 0.000321807602330961 0.00464224980187856 HLA-A/B2M/GATA3/PRKCZ/TFRC/LAPTM5/HLA-E/HLA-F/PTPRC/CD55/DHX36/CD86/DDX1/CD74/TGFB1/RSAD2/PHB/LILRB1 18 GO:0009144 purine nucleoside triphosphate metabolic process 15/1165 88/18722 0.000322550761220851 0.00464224980187856 ALDOA/TMSB4X/PARP1/VCP/RHOA/RAN/AK3/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/NME1/IMPDH2 15 GO:0071216 cellular response to biotic stimulus 30/1165 246/18722 0.000325632654059501 0.00467461914894113 ASS1/PRDX2/NFKBIA/PDCD4/ZFP36/CEBPB/HSPA5/CD14/RHOA/GSTP1/VIM/CD55/SPI1/CD86/PYCARD/TGFB1/CD68/TXNIP/TREM2/LILRB2/HCK/CCDC47/TLR2/LILRB1/CXCL10/TSPO/SYK/LILRA2/TNFRSF1B/LYN 30 GO:1902882 regulation of response to oxidative stress 16/1165 98/18722 0.000343261941817433 0.00491512571280932 MET/BMP7/PAGE4/SOD2/PARP1/SOD1/PAWR/P4HB/SESN1/GPX1/FUT8/STK26/TREM2/PARK7/PPIA/GCH1 16 GO:0002369 T cell cytokine production 9/1165 37/18722 0.000345245176942985 0.00491842938624614 HLA-A/B2M/GATA3/PRKCZ/HLA-F/CD55/LILRB4/RSAD2/TNFRSF1B 9 GO:0002724 regulation of T cell cytokine production 9/1165 37/18722 0.000345245176942985 0.00491842938624614 HLA-A/B2M/GATA3/PRKCZ/HLA-F/CD55/LILRB4/RSAD2/TNFRSF1B 9 GO:0002707 negative regulation of lymphocyte mediated immunity 11/1165 53/18722 0.000350249964653562 0.00497709633316568 HLA-B/HLA-A/HLA-E/HLA-F/PTPRC/IL4I1/CD55/CD46/PTPN6/LILRB4/LILRB1 11 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 19/1165 128/18722 0.000355121743563164 0.00503358168338393 FBN1/FBN2/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/HSP90AB1/NREP/HSPA5/DAB2/HTRA1/LATS2/SKIL/EID2/TGFB1/SNX6/ZEB2 19 GO:0051101 regulation of DNA binding 18/1165 118/18722 0.000358074411052196 0.00506264904089667 ISL1/GATA3/TMSB4X/PARP1/MSX2/NFKBIA/ID1/PLAUR/KLF4/TGFB1/PARK7/HDAC2/ZNF593/NME1/IFI16/LAMTOR5/JUN/JAK2 18 GO:0019430 removal of superoxide radicals 7/1165 23/18722 0.000359604899066292 0.00507151331271129 BMP7/SOD3/SOD2/SOD1/PRDX2/PRDX1/GCH1 7 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 10/1165 45/18722 0.000361069349832009 0.00507940416192247 SOD2/PARP1/SOD1/P4HB/GPX1/ARL6IP5/TREM2/PARK7/PPIA/JAK2 10 GO:0016485 protein processing 28/1165 225/18722 0.000364727874121354 0.00509258098866458 SRGN/ENPEP/MME/CTSL/CTSS/PERP/PARP1/GLI3/DHCR24/CTSH/PISD/LGMN/BAG2/PRKACB/ASPH/AFG3L2/PMPCB/PYCARD/PGK1/MDM2/STOML2/ENO1/METAP2/CPM/BAD/IFI16/CLN3/ADAM8 28 GO:0034284 response to monosaccharide 28/1165 225/18722 0.000364727874121354 0.00509258098866458 CTSV/KRT18/LRP5/LDHA/GJA1/SOD2/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/RHOA/SOX4/GSTP1/SLC29A1/TXNIP/TREM2/CCDC186/TXN2/BAD/GLUL/NME1/FIS1/SLC8A1/LRP1/ENSA 28 GO:0050769 positive regulation of neurogenesis 28/1165 225/18722 0.000364727874121354 0.00509258098866458 LRP2/EGFR/SPINT1/MME/DAG1/CXCR4/SERPINF1/GLI3/ASPM/OBSL1/NRP1/PTN/GOLGA4/TGM2/VEGFA/ETV5/SKIL/DHX36/IL6ST/TGFB1/HDAC2/UFL1/TLR2/TSPO/RAB11A/LRP1/TNFRSF1B/LYN 28 GO:1900407 regulation of cellular response to oxidative stress 15/1165 89/18722 0.000365999568645389 0.00509765652309322 MET/BMP7/PAGE4/SOD2/PARP1/SOD1/PAWR/P4HB/GPX1/FUT8/STK26/TREM2/PARK7/PPIA/GCH1 15 GO:1903078 positive regulation of protein localization to plasma membrane 12/1165 62/18722 0.000379106656435607 0.00526714272914124 EGFR/SORBS1/ITGB1/DLG1/LGALS3/ATP2B4/CIB1/TREM2/RHOG/CLN3/RAB11A/LRP1 12 GO:0018212 peptidyl-tyrosine modification 41/1165 378/18722 0.000380419504809669 0.00527233254443623 EGFR/MET/EFEMP1/EPHB4/ISL1/APP/CD44/PRKCZ/ERBB3/WEE1/CD24/FLT1/IGF1R/PRLR/EFNA1/NRP1/NCF1/TPST2/YES1/PECAM1/VEGFA/PTPRC/IL6ST/CD74/PTPN6/TGFB1/VPS25/TREM2/LILRB4/HCK/HDAC2/JAK1/IGF2/FGR/SNX6/SOCS3/PARP9/SYK/CD300A/JAK2/LYN 41 GO:0031341 regulation of cell killing 16/1165 99/18722 0.000386212201247601 0.00533943124532706 HLA-B/HLA-A/B2M/TYROBP/CADM1/HSP90AB1/HLA-E/CD59/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/SPI1/LILRB1/SYK 16 GO:0045591 positive regulation of regulatory T cell differentiation 6/1165 17/18722 0.000390995688129014 0.00539228205766132 HLA-DRA/HLA-DRB1/IL4I1/CD46/LILRB2/LILRB4 6 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 30/1165 249/18722 0.000400689928263995 0.00551243276310246 WLS/GJA1/TFRC/S100A4/GAPDH/NDFIP2/BRD4/STAT1/HLA-DRB1/S100A13/RHOA/TGM2/SLC44A2/FLNA/GSTP1/TMED4/TFG/DHX36/DDX1/CD74/TNFSF10/PYCARD/TREM2/SECTM1/TRIM22/LILRB4/UFL1/S100A12/BST2/LAMTOR5 30 GO:0061572 actin filament bundle organization 22/1165 161/18722 0.000418807871933632 0.00574760045272244 MET/CALD1/TACSTD2/SORBS1/PAWR/HSP90B1/TJP1/ITGB5/FERMT2/PDLIM1/LIMA1/S100A10/NRP1/AIF1/SLC9A1/ID1/LCP1/RHOA/FLNA/EPS8/WASF2/STMN1 22 GO:0097242 amyloid-beta clearance 9/1165 38/18722 0.000427678288182551 0.00585502007699673 LRP2/MME/IGF1R/APOE/LRPAP1/CLTC/TREM2/RAB11A/LRP1 9 GO:0051897 positive regulation of protein kinase B signaling 18/1165 120/18722 0.000441358511981069 0.00600964965567019 LRP2/EGFR/MET/GATA3/HSP90AB1/FERMT2/IGF1R/HSP90AA1/ITGB1/GPX1/C1QBP/TGFB1/GDF15/PARK7/MYDGF/IGF2/PHB/ADAM8 18 GO:0031343 positive regulation of cell killing 12/1165 63/18722 0.000442185160839442 0.00600964965567019 HLA-B/HLA-A/B2M/TYROBP/CADM1/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/SPI1/SYK 12 GO:0050854 regulation of antigen receptor-mediated signaling pathway 12/1165 63/18722 0.000442185160839442 0.00600964965567019 SLC39A10/PAWR/LAPTM5/KCNN4/GBP1/PTPRC/LGALS3/PTPN6/LILRB4/RPS3/CD300A/LYN 12 GO:0008154 actin polymerization or depolymerization 27/1165 217/18722 0.000461600540814374 0.00625836675263547 KANK1/TMSB4X/KANK4/RASA1/SCIN/TMSB10/DSTN/LIMA1/AIF1/COTL1/DLG1/RHOA/ARPC3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/VASP/WASL/ADD3/IQGAP2/WIPF1/JAK2 27 GO:0051099 positive regulation of binding 23/1165 173/18722 0.000466330710655729 0.00630726332267616 MET/ISL1/B2M/APP/GATA3/PARP1/HSP90AB1/S100A10/NRP1/APOE/PLAUR/RAN/KLF4/TGFB1/PARK7/STMN1/NME1/GMNN/LAMTOR5/MBD2/PARP9/LRP1/JAK2 23 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 19/1165 131/18722 0.000478177736008133 0.00645195103897512 FBN1/FBN2/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/HSP90AB1/NREP/HSPA5/DAB2/HTRA1/LATS2/SKIL/EID2/TGFB1/SNX6/ZEB2 19 GO:0001892 embryonic placenta development 14/1165 82/18722 0.00049620505510519 0.00666315544092208 NR2F2/BMP7/SPINT1/KRT8/PHLDA2/SPINT2/EPAS1/CEBPB/GRB2/JUNB/KRT19/IGF2/ZFP36L1/SOCS3 14 GO:0009205 purine ribonucleoside triphosphate metabolic process 14/1165 82/18722 0.00049620505510519 0.00666315544092208 ALDOA/TMSB4X/PARP1/VCP/RHOA/RAN/AK3/TGFB1/STOML2/TREM2/ENO1/SLC25A13/NME1/IMPDH2 14 GO:0032102 negative regulation of response to external stimulus 44/1165 420/18722 0.000501086059926379 0.00671263974789205 SEMA6A/SEMA6D/HLA-B/HLA-A/DPP4/GJA1/ISL1/SERPINF1/GATA3/ISG15/SOD1/HLA-E/NRP1/AIF1/PRDX2/FGL2/DUSP1/APOE/YES1/ZFP36/HLA-F/GPX1/HLA-DRB1/HTRA1/PTPRC/C1QBP/GSTP1/CD9/A2M/KLF4/TREM2/OAS1/HCK/NENF/FGR/LILRB1/IFI16/SOCS3/SYK/LILRA2/TNFRSF1B/PSMB4/GRN/LYN 44 GO:0016064 immunoglobulin mediated immune response 26/1165 207/18722 0.000504310346079269 0.00673801327970678 B2M/HSPD1/TFRC/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/C1QA/C1QB/C1QC/HLA-DRB1/HLA-DPB1/PTPRC/C1QBP/CD55/CD46/CD74/PTPN6/TGFB1/TREM2/IRF7/HLA-DMA/HLA-DQA1/GAPT/HLA-DQA2/HLA-DMB 26 GO:0071635 negative regulation of transforming growth factor beta production 5/1165 12/18722 0.000506581436671345 0.00673801327970678 TYROBP/HSP90AB1/CD24/LILRB1/CD2AP 5 GO:1904667 negative regulation of ubiquitin protein ligase activity 5/1165 12/18722 0.000506581436671345 0.00673801327970678 RPL23/BAG2/RPL5/RPL37/RPS7 5 GO:0071674 mononuclear cell migration 25/1165 196/18722 0.000509055590700075 0.00675491496595631 CXCR4/APP/GATA3/FLT1/AIF1/DUSP1/LGMN/PECAM1/RHOA/C1QBP/CCL3L3/LGALS3/EPS8/SPI1/PYCARD/MSN/MYO1G/CALR/WASL/S100A12/CXCL10/CXCL16/CCL4/ADAM8/LYN 25 GO:0001774 microglial cell activation 10/1165 47/18722 0.000523296569838121 0.00686134781044876 TYROBP/APP/IFNGR2/AIF1/C1QA/PTPRC/TREM2/TLR2/JAK2/GRN 10 GO:0042311 vasodilation 10/1165 47/18722 0.000523296569838121 0.00686134781044876 EGFR/GJA5/ADRB1/GJA1/SOD2/SOD1/KLF2/APOE/GPX1/GCH1 10 GO:0046677 response to antibiotic 10/1165 47/18722 0.000523296569838121 0.00686134781044876 SOD1/SLC9A1/RPL23/HSP90AA1/HSPA5/CRIP1/SLC1A3/MDM2/JAK1/JAK2 10 GO:0060828 regulation of canonical Wnt signaling pathway 30/1165 253/18722 0.000524374515700328 0.00686134781044876 EGFR/KANK1/LGR5/WLS/LGR4/FERMT1/ISL1/ZNRF3/FOLR1/GLI3/ASPM/NOTUM/GPC3/YAP1/APOE/TBL1X/DLX5/VCP/DAB2/SIAH2/SOX4/LATS2/RPS12/PFDN5/RUVBL1/TGFB1/USP47/TLE4/SULF2/ZEB2 30 GO:0001914 regulation of T cell mediated cytotoxicity 9/1165 39/18722 0.000525633272491175 0.00686134781044876 HLA-B/HLA-A/B2M/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/LILRB1 9 GO:0051084 'de novo' posttranslational protein folding 9/1165 39/18722 0.000525633272491175 0.00686134781044876 HSPE1/ST13/HSPA5/DNAJB4/CCT2/CD74/ERO1A/SDF2/HSPA8 9 GO:2000249 regulation of actin cytoskeleton reorganization 9/1165 39/18722 0.000525633272491175 0.00686134781044876 TJP1/NRP1/GMFG/HCK/ARHGDIB/HRAS/ABI3/IQGAP2/CD2AP 9 GO:0002700 regulation of production of molecular mediator of immune response 22/1165 164/18722 0.000541801476417006 0.00705598999333794 HLA-A/B2M/GATA3/PRKCZ/TFRC/LAPTM5/HLA-E/HLA-F/PRKDC/PTPRC/CD55/DHX36/CD86/DDX1/CD74/TGFB1/LILRB4/RSAD2/PHB/LILRB1/BST2/TNFRSF1B 22 GO:0009141 nucleoside triphosphate metabolic process 17/1165 112/18722 0.00054742489819216 0.00711272211470507 ALDOA/TMSB4X/PARP1/VCP/RHOA/RAN/AK3/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/TYMS/NME1/IMPDH2/DUT 17 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 24/1165 186/18722 0.000551810879524669 0.00715315119346874 WLS/GJA1/TFRC/S100A4/GAPDH/NDFIP2/BRD4/HLA-DRB1/S100A13/RHOA/TGM2/SLC44A2/FLNA/TMED4/TFG/DHX36/DDX1/CD74/TNFSF10/SECTM1/TRIM22/S100A12/BST2/LAMTOR5 24 GO:0038061 NIK/NF-kappaB signaling 20/1165 143/18722 0.00055553602568477 0.00718484726306132 EGFR/BMP7/APP/TMSB4X/LAPTM5/NFKBIA/PDCD4/PRDX1/CD14/RHOA/SPI1/CD86/TRIP6/TREM2/LIMS1/CALR/PHB/TLR2/NFAT5/RPS3 20 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 11/1165 56/18722 0.000576604240331507 0.00742311835087328 HLA-B/HLA-A/B2M/TYROBP/CADM1/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/SPI1 11 GO:0010332 response to gamma radiation 11/1165 56/18722 0.000576604240331507 0.00742311835087328 GATA3/PARP1/CYBA/YAP1/GPX1/HSPA5/PRKDC/PTPRC/MDM2/HRAS/CXCL10 11 GO:1902905 positive regulation of supramolecular fiber organization 26/1165 209/18722 0.000584399723139403 0.00750626005945416 MET/APP/FERMT2/SCIN/DSTN/S100A10/NRP1/APOE/ID1/DLG1/GPX1/RHOA/CLIP1/ARPC3/FLNA/GMFG/GRB2/ARPC5L/AKAP9/PYCARD/WASF2/HCK/VASP/WASL/IQGAP2/RPS3 26 GO:0002437 inflammatory response to antigenic stimulus 13/1165 74/18722 0.000587950184766686 0.00753462188834568 GATA3/HLA-E/YES1/GPX1/HLA-DRB1/CD68/TREM2/PARK7/HCK/FGR/SYK/PSMB4/LYN 13 GO:0033273 response to vitamin 15/1165 93/18722 0.000593697532649913 0.00759094362360811 EGFR/BMP7/SOD2/FOLR1/PTN/ATP2B1/GSTP1/DNMT3A/CCND1/MDM2/KYNU/TYMS/CXCL10/SRSF2/TSPO 15 GO:0071677 positive regulation of mononuclear cell migration 12/1165 65/18722 0.000595115172542501 0.00759177605336605 APP/AIF1/LGMN/RHOA/C1QBP/LGALS3/SPI1/PYCARD/CALR/CXCL10/CCL4/ADAM8 12 GO:0008064 regulation of actin polymerization or depolymerization 24/1165 187/18722 0.000596594815477266 0.00759339387590453 KANK1/TMSB4X/KANK4/RASA1/SCIN/TMSB10/DSTN/LIMA1/COTL1/DLG1/RHOA/ARPC3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/VASP/WASL/ADD3/IQGAP2 24 GO:0032271 regulation of protein polymerization 28/1165 232/18722 0.000598610755766748 0.00760181486904696 KANK1/MET/TMSB4X/KANK4/RASA1/SCIN/TMSB10/COTL1/HSP90AA1/DLG1/RHOA/CLIP1/ARPC3/EPS8/GMFG/GRB2/ARPC5L/AKAP9/PYCARD/WASF2/TRIOBP/HCK/STMN1/VASP/WASL/ADD3/IQGAP2/RPS3 28 GO:0042744 hydrogen peroxide catabolic process 8/1165 32/18722 0.000602388089146949 0.00763251545007184 PRDX4/PRDX2/PRDX1/PRDX5/GPX1/PRDX3/PRDX6/GPX3 8 GO:0014013 regulation of gliogenesis 16/1165 103/18722 0.00060747374516544 0.00764879783756585 LRP2/EGFR/SPINT1/DAG1/CXCR4/PTN/ETV5/IL6ST/TGFB1/TREM2/HDAC2/UFL1/TLR2/TSPO/TNFRSF1B/LYN 16 GO:0045639 positive regulation of myeloid cell differentiation 16/1165 103/18722 0.00060747374516544 0.00764879783756585 TYROBP/ISG15/SCIN/STAT1/FOS/HLA-DRB1/PRKDC/PITHD1/EVI2B/FAM210B/CD74/TGFB1/TREM2/ZFP36L1/PRMT1/JUN 16 GO:0002708 positive regulation of lymphocyte mediated immunity 17/1165 113/18722 0.000607761239186597 0.00764879783756585 HLA-B/HLA-A/B2M/CADM1/GATA3/PRKCZ/HSPD1/TFRC/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/CD55/TGFB1/TREM2/RSAD2 17 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 27/1165 221/18722 0.000614908978716697 0.00772144093408685 LAPTM5/HSP90AB1/EFNA1/RPL23/APOE/PSMD14/MAGEF1/PSME2/GPX1/VCP/DAB2/BAG2/UBB/PITHD1/PSMC1/PSMC3/PSMC6/RPL5/MDM2/TREM2/USP14/PARK7/RAD23B/RPS7/PSMC4/UFL1/PSME1 27 GO:0018108 peptidyl-tyrosine phosphorylation 40/1165 375/18722 0.000621427771873075 0.00778587965072226 EGFR/MET/EFEMP1/EPHB4/ISL1/APP/CD44/PRKCZ/ERBB3/WEE1/CD24/FLT1/IGF1R/PRLR/EFNA1/NRP1/NCF1/YES1/PECAM1/VEGFA/PTPRC/IL6ST/CD74/PTPN6/TGFB1/VPS25/TREM2/LILRB4/HCK/HDAC2/JAK1/IGF2/FGR/SNX6/SOCS3/PARP9/SYK/CD300A/JAK2/LYN 40 GO:0019724 B cell mediated immunity 26/1165 210/18722 0.000628464197227031 0.00783018351214238 B2M/HSPD1/TFRC/HLA-E/FCER1G/HLA-DPA1/HLA-DRA/C1QA/C1QB/C1QC/HLA-DRB1/HLA-DPB1/PTPRC/C1QBP/CD55/CD46/CD74/PTPN6/TGFB1/TREM2/IRF7/HLA-DMA/HLA-DQA1/GAPT/HLA-DQA2/HLA-DMB 26 GO:0032753 positive regulation of interleukin-4 production 7/1165 25/18722 0.000631938915196953 0.00783018351214238 GATA3/PRKCZ/HLA-E/FCER1G/CEBPB/CD86/SYK 7 GO:0071450 cellular response to oxygen radical 7/1165 25/18722 0.000631938915196953 0.00783018351214238 BMP7/SOD3/SOD2/SOD1/PRDX2/PRDX1/GCH1 7 GO:0071451 cellular response to superoxide 7/1165 25/18722 0.000631938915196953 0.00783018351214238 BMP7/SOD3/SOD2/SOD1/PRDX2/PRDX1/GCH1 7 GO:1900078 positive regulation of cellular response to insulin stimulus 7/1165 25/18722 0.000631938915196953 0.00783018351214238 SORBS1/PRKCZ/ESRRA/NUCKS1/IGF2/GNAI2/SORL1 7 GO:0060070 canonical Wnt signaling pathway 34/1165 303/18722 0.000636601950294261 0.00785871409131023 EGFR/KANK1/LGR5/WLS/LGR4/LRP5/FERMT1/ISL1/ZNRF3/FOLR1/GATA3/GLI3/ASPM/NOTUM/GPC3/PLPP3/YAP1/APOE/TBL1X/DLX5/VCP/DAB2/SIAH2/SOX4/LATS2/RPS12/PFDN5/KLF4/RUVBL1/TGFB1/USP47/TLE4/SULF2/ZEB2 34 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 30/1165 256/18722 0.000638088990941986 0.00785871409131023 FBN1/LRP2/FBN2/CRIM1/TGFBR3/BMP7/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/PARP1/FSTL1/HSP90AB1/GPC3/RBPMS/NREP/HSPA5/DAB2/HTRA1/LATS2/SKIL/EID2/TGFB1/GDF15/SNX6/LRP1/ZEB2/SORL1/JAK2 30 GO:0002768 immune response-regulating cell surface receptor signaling pathway 35/1165 315/18722 0.000639220027355974 0.00785871409131023 HLA-A/TYROBP/GATA3/SLC39A10/PAWR/LAPTM5/FCN1/CD24/FCER1G/KCNN4/YES1/GBP1/HLA-DRB1/HLA-DPB1/PTPRC/VAV3/LGALS3/PLSCR1/PTPN6/STOML2/LILRB2/LILRB4/HCK/FPR1/MYO1G/HRAS/FPR3/MNDA/FGR/LILRB1/RPS3/SYK/CD300A/LILRA2/LYN 35 GO:0043112 receptor metabolic process 22/1165 166/18722 0.00064028175350913 0.00785871409131023 RNF43/NSG1/ZNRF3/TFRC/LAPTM5/FCER1G/APOE/ITGB1/LGMN/FUT8/LRPAP1/VEGFA/CD9/GRB2/CLTC/MYLIP/TGFB1/LILRB4/LILRB1/SYK/LRP1/SORL1 22 GO:0030501 positive regulation of bone mineralization 9/1165 40/18722 0.000641241947945855 0.00785871409131023 FBN2/BMP7/ISG15/TFAP2A/PTN/ATP2B1/TGFB1/SLC8A1/ATRAID 9 GO:0030832 regulation of actin filament length 24/1165 188/18722 0.000644515928212712 0.0078816294227842 KANK1/TMSB4X/KANK4/RASA1/SCIN/TMSB10/DSTN/LIMA1/COTL1/DLG1/RHOA/ARPC3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/VASP/WASL/ADD3/IQGAP2 24 GO:0050708 regulation of protein secretion 31/1165 268/18722 0.000652233068736172 0.00794139742910224 EGFR/MYH10/DPP4/WLS/LRP5/GJA1/ISL1/EXPH5/SYT7/FRMD4A/KCNN4/APOE/MPC2/HLA-DRB1/HMGN3/SOX4/SERP1/TGFB1/TREM2/UQCC2/RSAD2/BAD/PPIA/TLR2/GLUL/ERP29/CD2AP/ADAM8/LRP1/JAK2/ENSA 31 GO:0051348 negative regulation of transferase activity 31/1165 268/18722 0.000652233068736172 0.00794139742910224 NR2F2/BMP7/LRP5/CDKN1C/PKIB/MLLT1/RPL23/DUSP1/NPM1/APOE/PDCD4/ZFP36/BAG2/PTPRC/LATS2/GSTP1/PYCARD/PTPN6/RPL5/RPL37/VPS25/PRDX3/PARK7/LILRB4/RPS7/PPIA/SNX6/SLC8A1/SORL1/CD300A/LYN 31 GO:0022613 ribonucleoprotein complex biogenesis 47/1165 463/18722 0.000656898859438013 0.00798089458447093 RPS17/RPS21/RPSA/HSP90AB1/MRPL1/RPS27/NPM1/SNRPF/HSP90AA1/RPLP0/PRKDC/C1QBP/SURF6/RPS28/RPS5/SNRPG/SNU13/DDX27/DDX1/RAN/MRPL20/RUVBL1/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/EIF3A/BRIX1/EIF2S2/EIF5/SNRPD1/RPS7/SNRPE/EIF3J/NHP2/RPS16/MRPS7/SNRPD2/GLUL/NOP56/SF1/SNRPD3/IMP3/RPL10A/SNRPC 47 GO:0061326 renal tubule development 15/1165 94/18722 0.00066655696846967 0.0080807435507997 LAMA5/LGR5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/CD24/YAP1/STAT1/DLG1/VEGFA 15 GO:0043491 protein kinase B signaling 26/1165 211/18722 0.000675405769895189 0.00817037195349503 LRP2/EGFR/MET/DAG1/GATA3/HSP90AB1/FERMT2/IGF1R/PHLDA3/HSP90AA1/ITGB1/DLG1/GPX1/C1QBP/KLF4/CIB1/TGFB1/GDF15/PARK7/MYDGF/IGF2/PHB/RRAS/ZFP36L1/PDCD6/ADAM8 26 GO:0005996 monosaccharide metabolic process 30/1165 257/18722 0.000680535092327528 0.00821471714674068 LRP5/SLC2A1/PHLDA2/SORBS1/ALDOA/SLC35B4/DDB1/GAPDH/RPIA/FBP1/AKR1B1/TPI1/PMAIP1/FUT8/PGP/FUCA1/DCXR/SERP1/PGK1/SLC2A3/GSTO1/ENO1/OAS1/SLC25A13/IGF2/BAD/SLC25A1/FAM3C/FUCA2/NUDT5 30 GO:0046631 alpha-beta T cell activation 21/1165 156/18722 0.00068434936260216 0.00824303212936894 HLA-A/CTSL/GATA3/PRKCZ/GLI3/HLA-E/HLA-DRA/HLA-DRB1/RHOA/PTPRC/CD55/CD86/IRF1/STOML2/LILRB4/RSAD2/LILRB1/SYK/PNP/CD83/CD300A 21 GO:0001656 metanephros development 14/1165 85/18722 0.000720820139749626 0.00864522103507403 FBN1/BMP7/LGR4/DLG5/FRAS1/GATA3/GLI3/IRX2/GPC3/YAP1/CTSH/STAT1/AKR1B1/BASP1 14 GO:0009142 nucleoside triphosphate biosynthetic process 14/1165 85/18722 0.000720820139749626 0.00864522103507403 ALDOA/TMSB4X/PARP1/VCP/AK3/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/TYMS/NME1/IMPDH2 14 GO:0071621 granulocyte chemotaxis 18/1165 125/18722 0.00072624245563687 0.00869168209699307 DPP4/JAM3/FCER1G/BSG/S100A8/PPIB/VAV3/C1QBP/CCL3L3/LGALS3/TREM1/CD74/CSF3R/PPIA/S100A12/CXCL10/CCL4/SYK 18 GO:0001913 T cell mediated cytotoxicity 10/1165 49/18722 0.00074166435364997 0.00881983478185865 HLA-B/HLA-A/B2M/HLA-E/HLA-DRA/CTSH/HLA-F/HLA-DRB1/PTPRC/LILRB1 10 GO:0043457 regulation of cellular respiration 10/1165 49/18722 0.00074166435364997 0.00881983478185865 VCP/RHOA/CISD1/OPN3/PARK7/UQCC2/COX7A2/ISCU/BNIP3/IL10RB 10 GO:0070169 positive regulation of biomineral tissue development 10/1165 49/18722 0.00074166435364997 0.00881983478185865 FBN2/BMP7/ISG15/TFAP2A/PTN/ATP2B1/CEBPB/TGFB1/SLC8A1/ATRAID 10 GO:0007044 cell-substrate junction assembly 15/1165 95/18722 0.00074688168033502 0.00882578288783256 ITGB4/ITGA6/LAMC1/SORBS1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/TRIP6/DST/LIMS1/PTPRA/LRP1 15 GO:0032479 regulation of type I interferon production 15/1165 95/18722 0.00074688168033502 0.00882578288783256 ISG15/HSPD1/GAPDH/HSP90AA1/STAT1/CD14/DHX36/IRF1/PYCARD/IRF7/OAS1/OAS2/TLR2/LILRB1/SYK 15 GO:0032606 type I interferon production 15/1165 95/18722 0.00074688168033502 0.00882578288783256 ISG15/HSPD1/GAPDH/HSP90AA1/STAT1/CD14/DHX36/IRF1/PYCARD/IRF7/OAS1/OAS2/TLR2/LILRB1/SYK 15 GO:0030041 actin filament polymerization 24/1165 190/18722 0.000750502995746996 0.0088499439393443 KANK1/TMSB4X/KANK4/RASA1/SCIN/TMSB10/AIF1/COTL1/DLG1/RHOA/ARPC3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/VASP/WASL/ADD3/IQGAP2/JAK2 24 GO:0034110 regulation of homotypic cell-cell adhesion 8/1165 33/18722 0.000752255445949004 0.00885201219729929 ANK3/PLAUR/CD9/IL6ST/JAK1/SYK/JAK2/LYN 8 GO:0070371 ERK1 and ERK2 cascade 36/1165 330/18722 0.000756222359902665 0.00888007553584447 SEMA6A/EGFR/FBLN1/DUSP9/TIMP3/APP/CD44/PRKCZ/FERMT2/NRP1/DUSP1/APOE/CTSH/DLG1/GBP1/HLA-DRB1/PTPRC/CCL3L3/GSTP1/KLF4/CD74/CIB1/PYCARD/PTPN6/TGFB1/EIF3A/TREM2/HRAS/PHB/RRAS/GNAI2/CCL4/ZFP36L1/SYK/LRP1/LYN 36 GO:0072028 nephron morphogenesis 13/1165 76/18722 0.00076463780192918 0.00896015027605112 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/STAT1/DLG1/VEGFA 13 GO:0051444 negative regulation of ubiquitin-protein transferase activity 6/1165 19/18722 0.000769778595853724 0.00898476574812954 RPL23/BAG2/RPL5/RPL37/PARK7/RPS7 6 GO:0032733 positive regulation of interleukin-10 production 9/1165 41/18722 0.000776810787337966 0.00898476574812954 ISG15/PRKCZ/HSPD1/CD46/PYCARD/TREM2/TLR2/SYK/CD83 9 GO:0050856 regulation of T cell receptor signaling pathway 9/1165 41/18722 0.000776810787337966 0.00898476574812954 PAWR/LAPTM5/KCNN4/GBP1/LGALS3/PTPN6/LILRB4/RPS3/CD300A 9 GO:0071634 regulation of transforming growth factor beta production 9/1165 41/18722 0.000776810787337966 0.00898476574812954 FERMT1/TYROBP/LTBP1/HSP90AB1/CD24/ITGB8/CD46/LILRB1/CD2AP 9 GO:0010917 negative regulation of mitochondrial membrane potential 5/1165 13/18722 0.000781144786226121 0.00898476574812954 BNIP3L/PMAIP1/HEBP2/ARL6IP5/BNIP3 5 GO:0034112 positive regulation of homotypic cell-cell adhesion 5/1165 13/18722 0.000781144786226121 0.00898476574812954 ANK3/PLAUR/IL6ST/JAK1/JAK2 5 GO:1900115 extracellular regulation of signal transduction 5/1165 13/18722 0.000781144786226121 0.00898476574812954 FBN1/FBN2/LTBP1/LRPAP1/CD46 5 GO:1900116 extracellular negative regulation of signal transduction 5/1165 13/18722 0.000781144786226121 0.00898476574812954 FBN1/FBN2/LTBP1/LRPAP1/CD46 5 GO:2001198 regulation of dendritic cell differentiation 5/1165 13/18722 0.000781144786226121 0.00898476574812954 HLA-B/CEBPB/LILRB2/TMEM176B/LILRB1 5 GO:0061077 chaperone-mediated protein folding 12/1165 67/18722 0.000790127995977205 0.00906950601517393 HSPE1/ST13/HSPA5/PPIB/PDIA4/DNAJB4/CCT2/CD74/ERO1A/SDF2/HSPA8/FKBP2 12 GO:0033002 muscle cell proliferation 29/1165 248/18722 0.000806103847154204 0.00923400182464601 EGFR/TGFBR3/ADAMTS1/GJA1/SOD2/CYBA/YAP1/AIF1/APOE/PDCD4/COMT/STAT1/DNMT1/AKR1B1/SKP2/PRKDC/RHOA/TGM2/HPGD/GSTP1/KLF4/TGFB1/MDM2/PHB/GNAI2/SF1/JUN/JAK2/CCNB1 29 GO:0050821 protein stabilization 24/1165 191/18722 0.00080895548997755 0.00924779463389815 TYROBP/AAK1/USP27X/HSPD1/HSP90AB1/GAPDH/PLPP3/EFNA1/RPL23/NPM1/TBL1X/HSP90AA1/BAG2/PPIB/SOX4/FLNA/CCT2/IFI30/RPL5/PARK7/RPS7/CALR/PHB/GRN 24 GO:0071692 protein localization to extracellular region 39/1165 368/18722 0.00081734100602882 0.00932161135112286 FBN1/FBN2/EGFR/MYH10/DPP4/WLS/LRP5/GJA1/ISL1/EXPH5/FAM3B/LTBP1/SYT7/FRMD4A/KCNN4/APOE/MPC2/HLA-DRB1/HMGN3/PDIA4/SOX4/CAMK2G/SERP1/TGFB1/TREM2/PARK7/UQCC2/CCDC186/RSAD2/BAD/PPIA/TLR2/GLUL/ERP29/CD2AP/ADAM8/LRP1/JAK2/ENSA 39 GO:0060669 embryonic placenta morphogenesis 7/1165 26/18722 0.000818734080902115 0.00932161135112286 BMP7/SPINT1/SPINT2/GRB2/IGF2/ZFP36L1/SOCS3 7 GO:0021782 glial cell development 17/1165 116/18722 0.000824163223596173 0.00934551146271782 EGFR/ITGB4/DAG1/APP/CDK6/SOD1/C1QA/S100A8/SOX4/GSTP1/VIM/CD9/TREM2/TLR2/LRP1/GRN/LYN 17 GO:0043200 response to amino acid 17/1165 116/18722 0.000824163223596173 0.00934551146271782 SLC38A9/CYBA/ASS1/CYBB/PTN/GCLM/SESN1/DNMT1/CDO1/CEBPB/RHOA/GSTP1/DNMT3A/BAD/UFL1/LAMTOR5/LYN 17 GO:0072659 protein localization to plasma membrane 32/1165 284/18722 0.000844148319435375 0.00955283168748137 CDH1/LAMA5/EGFR/KRT18/NSG1/MAP7/SORBS1/PRKCZ/ANK3/S100A10/VAMP5/ITGB1/BSG/DLG1/GOLGA4/GBP1/DAB2/FLNA/LGALS3/CLTC/TMEM150A/ATP2B4/CIB1/ARL6IP5/TGFB1/TREM2/RHOG/ACTB/CLN3/ABI3/RAB11A/LRP1 32 GO:0002440 production of molecular mediator of immune response 34/1165 308/18722 0.00085025134958216 0.00960253687163917 HLA-A/B2M/GATA3/PRKCZ/HSPD1/TFRC/LAPTM5/HLA-E/HLA-DPA1/HLA-DRA/HLA-F/HLA-DRB1/PRKDC/HLA-DPB1/PTPRC/CD55/DHX36/CD86/TREM1/DDX1/CD74/TGFB1/LILRB4/RSAD2/PHB/HLA-DMA/CTNNBL1/HLA-DQA1/LILRB1/BST2/GAPT/HLA-DQA2/HLA-DMB/TNFRSF1B 34 GO:0051384 response to glucocorticoid 20/1165 148/18722 0.00086456971032192 0.0097446381205561 EGFR/CTSV/ISL1/SERPINF1/AGL/HSPD1/ASS1/ANXA3/AIF1/DUSP1/ZFP36/ATP2B1/CDO1/FOS/RHOA/GSTP1/CCND1/BAD/TYMS/ZFP36L1 20 GO:0046638 positive regulation of alpha-beta T cell differentiation 10/1165 50/18722 0.000876147507072578 0.00981599991456763 PRKCZ/GLI3/HLA-DRA/HLA-DRB1/RHOA/CD86/LILRB4/SYK/PNP/CD83 10 GO:0060337 type I interferon signaling pathway 10/1165 50/18722 0.000876147507072578 0.00981599991456763 IFITM3/ISG15/HSP90AB1/STAT1/IFITM2/PTPN6/IRF7/OAS1/JAK1/OAS2 10 GO:0110151 positive regulation of biomineralization 10/1165 50/18722 0.000876147507072578 0.00981599991456763 FBN2/BMP7/ISG15/TFAP2A/PTN/ATP2B1/CEBPB/TGFB1/SLC8A1/ATRAID 10 GO:0030048 actin filament-based movement 18/1165 127/18722 0.000878054429213259 0.00981675406333745 MYH10/SYNE2/GJA5/DSP/DSG2/GJA1/DSC2/SLC9A1/MYO7A/FNBP1L/DLG1/FLNA/AKAP9/WASF2/MYO1G/WASL/WIPF1/MYO1F 18 GO:0032640 tumor necrosis factor production 23/1165 181/18722 0.000881461615521481 0.00981675406333745 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/ZFP36/CD14/PTPRC/GSTP1/PYCARD/PTPN6/TREM2/OAS1/HDAC2/OAS2/TLR2/LILRB1/TSPO/SYK/JAK2/LILRA2 23 GO:0032680 regulation of tumor necrosis factor production 23/1165 181/18722 0.000881461615521481 0.00981675406333745 ISL1/TYROBP/APP/HSPD1/CYBA/HLA-E/CYBB/ZFP36/CD14/PTPRC/GSTP1/PYCARD/PTPN6/TREM2/OAS1/HDAC2/OAS2/TLR2/LILRB1/TSPO/SYK/JAK2/LILRA2 23 GO:0032535 regulation of cellular component size 40/1165 382/18722 0.000890608784521973 0.00986806587405219 SEMA6A/SEMA6D/KANK1/TMSB4X/KANK4/HSP90AB1/RASA1/SCIN/TMSB10/DSTN/LIMA1/KCNN4/NRP1/COTL1/NPM1/APOE/DLG1/GOLGA4/RHOA/VEGFA/ARPC3/VAV3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/MSN/TRIOBP/HCK/VASP/WASL/ADD3/CLN3/LAMTOR5/RAB11A/IQGAP2/LRP1/TMEM123 40 GO:0007346 regulation of mitotic cell cycle 46/1165 457/18722 0.000890875017928318 0.00986806587405219 EGFR/PBX1/ADAMTS1/BMP7/LRP5/CTDSPL/CDKN1C/APP/BTG3/OBSL1/WEE1/DDB1/AIF1/DUSP1/BRD4/CCND3/PSME2/DLG1/LGMN/FOXO4/PRKDC/AURKAIP1/SOX4/USP22/CCND1/KLF4/BRD7/PTPN6/TGFB1/ANAPC11/MDM2/CKS2/RPA3/MKI67/CENPF/USP47/IGF2/YWHAE/PSME1/CKS1B/RAD21/APEX1/BABAM1/ZFP36L1/RAB11A/CCNB1 46 GO:1990778 protein localization to cell periphery 36/1165 333/18722 0.000891343202947526 0.00986806587405219 CDH1/LAMA5/EGFR/KRT18/DAG1/NSG1/MAP7/SORBS1/PRKCZ/ANK3/S100A10/GNAI1/VAMP5/ITGB1/BSG/DLG1/GOLGA4/GBP1/DAB2/FLNA/LGALS3/CLTC/TMEM150A/ATP2B4/CIB1/ARL6IP5/TGFB1/TREM2/HRAS/RABEP1/RHOG/ACTB/CLN3/ABI3/RAB11A/LRP1 36 GO:0070372 regulation of ERK1 and ERK2 cascade 34/1165 309/18722 0.000899837666690672 0.00994249768333611 SEMA6A/EGFR/FBLN1/DUSP9/TIMP3/APP/CD44/PRKCZ/FERMT2/NRP1/DUSP1/APOE/DLG1/GBP1/HLA-DRB1/PTPRC/CCL3L3/GSTP1/KLF4/CD74/CIB1/PYCARD/PTPN6/TGFB1/EIF3A/TREM2/HRAS/PHB/RRAS/GNAI2/CCL4/SYK/LRP1/LYN 34 GO:0045137 development of primary sexual characteristics 27/1165 227/18722 0.000928192546800048 0.0102230830455283 LRP2/ADGRG1/NR2F2/ADAMTS1/CTSV/GATA3/PRDX4/RHOBTB3/SOD1/ASPM/ARID5B/NASP/TFAP2C/IDH1/CEBPB/HSPA5/VEGFA/UBB/FLNA/CCND1/TNFSF10/BASP1/EIF2S2/RETN/SF1/CGA/LHFPL2 27 GO:0051085 chaperone cofactor-dependent protein refolding 8/1165 34/18722 0.000930695784119892 0.0102230830455283 HSPE1/ST13/HSPA5/DNAJB4/CD74/ERO1A/SDF2/HSPA8 8 GO:1990000 amyloid fibril formation 8/1165 34/18722 0.000930695784119892 0.0102230830455283 B2M/APP/SIAH1/APOE/SIAH2/PFDN5/MDM2/TREM2 8 GO:0045687 positive regulation of glial cell differentiation 9/1165 42/18722 0.000934821925415735 0.0102283732307184 SPINT1/DAG1/CXCR4/PTN/IL6ST/TGFB1/HDAC2/TLR2/TNFRSF1B 9 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 9/1165 42/18722 0.000934821925415735 0.0102283732307184 TEAD1/GATA3/KLF5/FOS/SPI1/KLF4/GNL3/TGFB1/JUN 9 GO:0061138 morphogenesis of a branching epithelium 23/1165 182/18722 0.000951007967971975 0.0103845917654457 LAMA5/MET/MAGED1/PBX1/BMP7/SPINT1/LGR4/LRP5/DAG1/DLG5/TACSTD2/SPINT2/GLI3/GPC3/TBX3/YAP1/NRP1/CTSH/DLG1/TGM2/VEGFA/GRB2/SOCS3 23 GO:0031647 regulation of protein stability 33/1165 298/18722 0.000952799707679411 0.0103845917654457 TYROBP/AAK1/USP27X/HSPD1/HSP90AB1/GAPDH/PLPP3/EFNA1/DDOST/SIAH1/RPL23/NPM1/TBL1X/CTSH/HSP90AA1/BAG2/PPIB/PRKDC/SOX4/FLNA/CCT2/IFI30/MYLIP/PYCARD/RPL5/MDM2/PARK7/RPS7/USP47/CALR/PHB/HSPA8/GRN 33 GO:0030833 regulation of actin filament polymerization 22/1165 171/18722 0.000957053175206395 0.0104107354116928 KANK1/TMSB4X/KANK4/RASA1/SCIN/TMSB10/COTL1/DLG1/RHOA/ARPC3/EPS8/GMFG/GRB2/ARPC5L/PYCARD/WASF2/TRIOBP/HCK/VASP/WASL/ADD3/IQGAP2 22 GO:0009612 response to mechanical stimulus 26/1165 216/18722 0.00095894461440921 0.0104111336957039 EGFR/DAG1/SLC2A1/GJA1/USP53/CXCR4/TMEM150C/CYBA/SLC9A1/NFKBIA/PTN/STAT1/FOS/RHOA/IRF1/SLC1A3/TXNIP/RETN/BAD/CXCL10/BNIP3/MBD2/SLC8A1/JUN/MAP3K2/CCNB1 26 GO:0019693 ribose phosphate metabolic process 41/1165 396/18722 0.000964411337632943 0.010450271888289 ACSS1/SLC26A2/LDHA/APP/ALDOA/TMSB4X/PARP1/GAPDH/RPIA/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/VCP/RHOA/UPP1/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/ENO1/SLC25A13/KYNU/BAD/SLC25A1/NUDT5/NME1/IMPDH2/PNP 41 GO:0070373 negative regulation of ERK1 and ERK2 cascade 13/1165 78/18722 0.000983937331999869 0.0106413106830737 SEMA6A/FBLN1/DUSP9/TIMP3/DUSP1/DLG1/GBP1/PTPRC/GSTP1/KLF4/EIF3A/PHB/LYN 13 GO:0042391 regulation of membrane potential 44/1165 434/18722 0.000986476844435941 0.0106482587073441 GJA5/DSP/DSG2/ADRB1/GJA1/USP53/SOD2/GABRE/APP/PRKCZ/ANK3/PARP1/DSC2/SOD1/KCNN4/SLC9A1/BNIP3L/PTN/GCLM/DLG1/PMAIP1/GNA11/VCP/HEBP2/UBB/IFI6/FLNA/SLC25A36/AKAP9/ARL6IP5/DLD/SLC29A1/STOML2/PRDX3/TREM2/PARK7/GLRX/BAD/YWHAE/CLN3/TSPO/BNIP3/SLC8A1/JUN 44 GO:0002285 lymphocyte activation involved in immune response 24/1165 194/18722 0.00100864130643209 0.0108666096986628 GATA3/PRKCZ/HSPD1/TFRC/FCER1G/HLA-DRA/FGL2/HLA-F/LCP1/HLA-DRB1/PTPRC/LGALS3/SPI1/CD86/EIF2AK4/CD46/CD74/SLC11A1/TGFB1/APBB1IP/DOCK10/LILRB1/GAPT/HLA-DMB 24 GO:0002832 negative regulation of response to biotic stimulus 16/1165 108/18722 0.00102906017207766 0.0110653539192948 HLA-B/HLA-A/ISG15/HLA-E/PRDX2/FGL2/HLA-F/HTRA1/IL4I1/C1QBP/A2M/OAS1/LILRB1/IFI16/LILRA2/GRN 16 GO:0009145 purine nucleoside triphosphate biosynthetic process 12/1165 69/18722 0.00103580744844927 0.0111166103406229 ALDOA/TMSB4X/PARP1/VCP/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/NME1/IMPDH2 12 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 30/1165 264/18722 0.00105344241373989 0.011277696970797 EGFR/ISL1/APP/CD44/PRKCZ/ERBB3/CD24/EFNA1/NRP1/NCF1/YES1/PECAM1/VEGFA/PTPRC/IL6ST/CD74/PTPN6/TGFB1/VPS25/TREM2/LILRB4/HDAC2/IGF2/SNX6/SOCS3/PARP9/SYK/CD300A/JAK2/LYN 30 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 18/1165 129/18722 0.00105621447530416 0.011277696970797 HSPD1/LAPTM5/HSPE1/CTSH/PMAIP1/VCP/S100A8/RHOA/TNFSF10/PYCARD/ARL6IP5/BAD/FIS1/CYCS/RPS3/PDCD6/SYK/JAK2 18 GO:0031638 zymogen activation 11/1165 60/18722 0.00105684457627636 0.011277696970797 CTSL/PERP/DHCR24/CTSH/LGMN/ASPH/PYCARD/PGK1/ENO1/BAD/IFI16 11 GO:0001649 osteoblast differentiation 27/1165 229/18722 0.00105973872805362 0.0112871223540132 FBN2/CRIM1/BMP7/LGR4/LRP5/SMOC1/RRBP1/CDK6/GLI3/VCAN/MSX2/FERMT2/HSPE1/YAP1/CEBPB/DLX5/CLTC/ESRRA/IL6ST/JUNB/CCDC47/IGF2/PHB/UFL1/SND1/SUCO/ATRAID 27 GO:0007548 sex differentiation 31/1165 276/18722 0.00106278486728622 0.0112981277652984 LRP2/ADGRG1/NR2F2/PBX1/ADAMTS1/CTSV/LGR4/GATA3/PRDX4/RHOBTB3/SOD1/ASPM/ARID5B/DHCR24/TBX3/NASP/TFAP2C/IDH1/CEBPB/HSPA5/VEGFA/UBB/FLNA/CCND1/TNFSF10/BASP1/EIF2S2/RETN/SF1/CGA/LHFPL2 31 GO:0045860 positive regulation of protein kinase activity 40/1165 386/18722 0.00108671392902791 0.0115306716136742 EGFR/MAGED1/DAG1/PRKCZ/HSP90AB1/ERBB3/CD24/FERMT2/FLT1/PRLR/EFNA1/NCF1/CCND3/NPM1/HSP90AA1/DLG1/RHOA/VEGFA/PTPRC/CD86/CCND1/ATP2B4/CIB1/SLC11A1/TGFB1/CKS2/PARK7/HRAS/IGF2/PHB/PPIA/S100A12/CKS1B/ERP29/RPS3/SYK/ADAM8/CD300A/JAK2/CCNB1 40 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 13/1165 79/18722 0.00111193227924724 0.0117508568171474 OBSL1/FERMT2/S100A10/NRP1/P4HB/PRKDC/C1QBP/FLNA/DHX36/CIB1/LIMS1/TRIOBP/CALR 13 GO:2001236 regulation of extrinsic apoptotic signaling pathway 20/1165 151/18722 0.00111330601002911 0.0117508568171474 ITGA6/TIMP3/YAP1/NRP1/PRDX2/ITM2C/TNFRSF12A/GCLM/PMAIP1/GPX1/SIAH2/PTPRC/IFI6/GSTP1/LGALS3/SKIL/TNFSF10/PYCARD/PARK7/PEA15 20 GO:0014002 astrocyte development 9/1165 43/18722 0.00111793293076015 0.0117508568171474 EGFR/APP/CDK6/C1QA/S100A8/VIM/TREM2/LRP1/GRN 9 GO:0036230 granulocyte activation 9/1165 43/18722 0.00111793293076015 0.0117508568171474 TYROBP/FCER1G/ANXA3/STXBP2/SPI1/SYK/CD300A/LILRA2/GRN 9 GO:0071604 transforming growth factor beta production 9/1165 43/18722 0.00111793293076015 0.0117508568171474 FERMT1/TYROBP/LTBP1/HSP90AB1/CD24/ITGB8/CD46/LILRB1/CD2AP 9 GO:0072009 nephron epithelium development 16/1165 109/18722 0.00113793071124698 0.0119387010882791 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/CD24/YAP1/STAT1/DLG1/PECAM1/VEGFA/BASP1 16 GO:0009199 ribonucleoside triphosphate metabolic process 14/1165 89/18722 0.00114915368990903 0.0119641637367508 ALDOA/TMSB4X/PARP1/VCP/RHOA/RAN/AK3/TGFB1/STOML2/TREM2/ENO1/SLC25A13/NME1/IMPDH2 14 GO:0006521 regulation of cellular amino acid metabolic process 5/1165 14/18722 0.00115314672752222 0.0119641637367508 COMT/ATP2B4/PARK7/CLN3/SLC7A7 5 GO:0035437 maintenance of protein localization in endoplasmic reticulum 5/1165 14/18722 0.00115314672752222 0.0119641637367508 GJA1/HSPA5/GPAA1/KDELR1/KDELR2 5 GO:0070141 response to UV-A 5/1165 14/18722 0.00115314672752222 0.0119641637367508 EGFR/MME/TIMP1/CCND1/OPN3 5 GO:0071236 cellular response to antibiotic 5/1165 14/18722 0.00115314672752222 0.0119641637367508 SLC9A1/RPL23/HSPA5/CRIP1/MDM2 5 GO:1901857 positive regulation of cellular respiration 5/1165 14/18722 0.00115314672752222 0.0119641637367508 VCP/OPN3/PARK7/ISCU/IL10RB 5 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 18/1165 130/18722 0.00115627865045981 0.011974524105223 LMAN1/ERGIC2/VCP/TMED4/TMED1/TFG/ERGIC3/TMED9/TMED3/TRAPPC6A/TRAPPC2L/ARF4/KDELR1/YIF1A/CREB3L2/KDELR2/PDCD6/SORL1 18 GO:0009746 response to hexose 26/1165 219/18722 0.00117456853898068 0.0121415344554301 CTSV/KRT18/LRP5/LDHA/GJA1/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/RHOA/SOX4/SLC29A1/TXNIP/TREM2/CCDC186/TXN2/BAD/GLUL/NME1/FIS1/SLC8A1/LRP1/ENSA 26 GO:0009117 nucleotide metabolic process 48/1165 489/18722 0.00119143647891141 0.0122932591105326 ACSS1/SLC26A2/TYMP/LDHA/APP/ALDOA/QPRT/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/REXO2/VCP/RHOA/UPP1/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/PARK7/ENO1/SLC25A13/KYNU/BAD/TYMS/SLC25A1/NUDT5/NME1/IMPDH2/DNPH1/PARP9/PNP/DUT 48 GO:0071375 cellular response to peptide hormone stimulus 32/1165 290/18722 0.00119716107001212 0.0123296607082166 FBN1/KANK1/SORBS1/PRKCZ/PARP1/CYBA/ASS1/IGF1R/SLC9A1/CCND3/STAT1/ATP2B1/FOXO4/PRKDC/GSTP1/GRB2/PIK3C2A/ESRRA/NUCKS1/MDM2/PKM/GDF15/IGF2/PTPRA/GNAI2/APEX1/ZFP36L1/SOCS3/SORL1/JAK2/LYN/NR4A1 32 GO:0034113 heterotypic cell-cell adhesion 11/1165 61/18722 0.00121811388935554 0.0125224784999133 DSP/BMP7/DSG2/JAM3/CD44/PERP/DSC2/ITGB1/PTPRC/KLF4/LILRB2 11 GO:0050767 regulation of neurogenesis 38/1165 364/18722 0.00124916119061925 0.0127991569348296 LRP2/SEMA6A/EGFR/SEMA6D/BMP7/SPINT1/MME/DAG1/B2M/CXCR4/SERPINF1/GLI3/ASPM/OBSL1/YAP1/NRP1/PTN/ID1/GOLGA4/TGM2/VEGFA/ETV5/SKIL/DHX36/IL6ST/TGFB1/BHLHE41/TREM2/HDAC2/UFL1/PCM1/TLR2/TSPO/RAB11A/LRP1/SORL1/TNFRSF1B/LYN 38 GO:0071248 cellular response to metal ion 24/1165 197/18722 0.00124958809910683 0.0127991569348296 CDH1/EGFR/HSD17B1/B2M/SERPINF1/APP/TFAP2A/SYT7/ANK3/PARP1/SOD1/CYBB/NCF1/FBP1/LGMN/HSPA5/FOS/FUS/JUNB/CALR/TSPO/BNIP3/JUN/CCNB1 24 GO:0009408 response to heat 16/1165 110/18722 0.00125638106536335 0.0128452949360373 HSPD1/SOD1/HSP90AB1/RBBP7/HSP90AA1/VCP/CD14/DNAJB4/DHX36/HSBP1L1/HDAC2/CXCL10/YWHAE/TFEC/PDCD6/LYN 16 GO:0002429 immune response-activating cell surface receptor signaling pathway 32/1165 291/18722 0.00126706177526124 0.0129074732205832 HLA-A/TYROBP/GATA3/SLC39A10/PAWR/LAPTM5/FCN1/FCER1G/KCNN4/YES1/GBP1/HLA-DRB1/HLA-DPB1/PTPRC/VAV3/LGALS3/PLSCR1/PTPN6/STOML2/LILRB4/HCK/FPR1/MYO1G/HRAS/FPR3/MNDA/FGR/RPS3/SYK/CD300A/LILRA2/LYN 32 GO:0002757 immune response-activating signal transduction 32/1165 291/18722 0.00126706177526124 0.0129074732205832 HLA-A/TYROBP/GATA3/SLC39A10/PAWR/LAPTM5/FCN1/FCER1G/KCNN4/YES1/GBP1/HLA-DRB1/HLA-DPB1/PTPRC/VAV3/LGALS3/PLSCR1/PTPN6/STOML2/LILRB4/HCK/FPR1/MYO1G/HRAS/FPR3/MNDA/FGR/RPS3/SYK/CD300A/LILRA2/LYN 32 GO:0071478 cellular response to radiation 23/1165 186/18722 0.00127870670861171 0.0130025013685462 MME/ADIRF/GATA3/TIMP1/PARP1/CYBA/DDB1/YAP1/NET1/NPM1/PTN/HSPA5/DHX36/GRB2/EIF2AK4/CRIP1/NUCKS1/MDM2/OPN3/NMT1/HRAS/USP47/IFI16 23 GO:0072006 nephron development 19/1165 142/18722 0.00129631610957893 0.013157725719831 LAMA5/MAGED1/PBX1/BMP7/ENPEP/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/CD24/YAP1/STAT1/DLG1/PECAM1/VEGFA/BASP1/SULF2 19 GO:0071222 cellular response to lipopolysaccharide 25/1165 209/18722 0.00129998359049398 0.0131711333816656 ASS1/PRDX2/NFKBIA/PDCD4/ZFP36/CEBPB/CD14/RHOA/GSTP1/VIM/CD55/SPI1/CD86/PYCARD/TGFB1/CD68/LILRB2/HCK/TLR2/LILRB1/CXCL10/TSPO/LILRA2/TNFRSF1B/LYN 25 GO:0000303 response to superoxide 7/1165 28/18722 0.00132126248810341 0.013290764060438 BMP7/SOD3/SOD2/SOD1/PRDX2/PRDX1/GCH1 7 GO:0031342 negative regulation of cell killing 7/1165 28/18722 0.00132126248810341 0.013290764060438 HLA-B/HLA-A/HSP90AB1/HLA-E/HLA-F/PTPRC/LILRB1 7 GO:0032801 receptor catabolic process 7/1165 28/18722 0.00132126248810341 0.013290764060438 RNF43/ZNRF3/LAPTM5/APOE/LGMN/MYLIP/TGFB1 7 GO:0045589 regulation of regulatory T cell differentiation 7/1165 28/18722 0.00132126248810341 0.013290764060438 HLA-DRA/HLA-DRB1/IL4I1/IRF1/CD46/LILRB2/LILRB4 7 GO:0031295 T cell costimulation 9/1165 44/18722 0.0013289753210777 0.0133206044235877 DPP4/CD24/YES1/CD86/PTPN6/TNFSF13B/LILRB2/LILRB4/LYN 9 GO:0097178 ruffle assembly 9/1165 44/18722 0.0013289753210777 0.0133206044235877 KANK1/TACSTD2/SNX10/AIF1/SH3YL1/EPS8/HRAS/RHOG/ABI3 9 GO:0008406 gonad development 26/1165 221/18722 0.00134057633971877 0.0133890658271201 LRP2/ADGRG1/NR2F2/ADAMTS1/CTSV/GATA3/PRDX4/RHOBTB3/SOD1/ASPM/ARID5B/NASP/TFAP2C/IDH1/CEBPB/HSPA5/VEGFA/UBB/FLNA/CCND1/TNFSF10/BASP1/EIF2S2/RETN/SF1/CGA 26 GO:0071219 cellular response to molecule of bacterial origin 26/1165 221/18722 0.00134057633971877 0.0133890658271201 ASS1/PRDX2/NFKBIA/PDCD4/ZFP36/CEBPB/CD14/RHOA/GSTP1/VIM/CD55/SPI1/CD86/PYCARD/TGFB1/CD68/TREM2/LILRB2/HCK/TLR2/LILRB1/CXCL10/TSPO/LILRA2/TNFRSF1B/LYN 26 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 6/1165 21/18722 0.00138296887958143 0.0136906601782902 COX6C/COX7C/COX4I1/COX7A2/CYCS/COX6A1 6 GO:0045056 transcytosis 6/1165 21/18722 0.00138296887958143 0.0136906601782902 LRP2/IGF1R/LRPAP1/CLTC/RAB11A/LRP1 6 GO:0045655 regulation of monocyte differentiation 6/1165 21/18722 0.00138296887958143 0.0136906601782902 CDK6/HLA-DRB1/CD74/IRF7/ZFP36L1/JUN 6 GO:0048714 positive regulation of oligodendrocyte differentiation 6/1165 21/18722 0.00138296887958143 0.0136906601782902 DAG1/CXCR4/PTN/HDAC2/TLR2/TNFRSF1B 6 GO:0099515 actin filament-based transport 6/1165 21/18722 0.00138296887958143 0.0136906601782902 SYNE2/MYO7A/FNBP1L/MYO1G/WASL/MYO1F 6 GO:0032623 interleukin-2 production 11/1165 62/18722 0.00139907623371082 0.0138014321613688 GATA3/LAPTM5/ZFP36/GBP1/PTPRC/CD86/STOML2/LILRB4/RPS3/PNP/CD83 11 GO:0032663 regulation of interleukin-2 production 11/1165 62/18722 0.00139907623371082 0.0138014321613688 GATA3/LAPTM5/ZFP36/GBP1/PTPRC/CD86/STOML2/LILRB4/RPS3/PNP/CD83 11 GO:0008360 regulation of cell shape 20/1165 154/18722 0.00142090747687398 0.0139751166625992 MYH10/DAG1/ALDOA/RHOBTB3/RASA1/FERMT2/PTN/DLG1/RND3/RHOA/VEGFA/LST1/EPS8/RHOBTB1/MSN/PLEKHO1/HCK/FGR/RHOG/FMNL1 20 GO:0150115 cell-substrate junction organization 15/1165 101/18722 0.00142166250032855 0.0139751166625992 ITGB4/ITGA6/LAMC1/SORBS1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/TRIP6/DST/LIMS1/PTPRA/LRP1 15 GO:0002275 myeloid cell activation involved in immune response 14/1165 91/18722 0.00143293971350335 0.0140368073506008 TYROBP/FCER1G/ANXA3/STXBP2/S100A13/SPI1/PYCARD/TREM2/FGR/SYK/CD300A/LILRA2/GRN/LYN 14 GO:0072080 nephron tubule development 14/1165 91/18722 0.00143293971350335 0.0140368073506008 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/CD24/YAP1/STAT1/DLG1/VEGFA 14 GO:0051271 negative regulation of cellular component movement 38/1165 367/18722 0.00144968882408976 0.014176138274592 CDH1/SEMA6D/ADGRG1/KANK1/NR2F2/FBLN1/TGFBR3/TCAF1/DPP4/DAG1/GJA1/DLG5/TACSTD2/SPINT2/SERPINF1/GATA3/TIMP1/MARVELD3/AIF1/DUSP1/APOE/PTN/RHOA/GSTP1/CD9/KLF4/ATP2B4/CD74/STK26/TGFB1/ARHGDIB/CALR/RRAS/WASL/BST2/APEX1/LRP1/CD300A 38 GO:0009150 purine ribonucleotide metabolic process 38/1165 368/18722 0.00152250463344224 0.0148318814411525 ACSS1/SLC26A2/LDHA/APP/ALDOA/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/VCP/RHOA/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/ENO1/SLC25A13/KYNU/BAD/SLC25A1/NME1/IMPDH2/PNP 38 GO:0032609 interferon-gamma production 16/1165 112/18722 0.00152467407652681 0.0148318814411525 HLA-A/ISL1/GATA3/ISG15/HSPD1/LAPTM5/HLA-DPA1/CD14/HLA-DRB1/HLA-DPB1/C1QBP/PYCARD/SLC11A1/LILRB4/HRAS/LILRB1 16 GO:0032649 regulation of interferon-gamma production 16/1165 112/18722 0.00152467407652681 0.0148318814411525 HLA-A/ISL1/GATA3/ISG15/HSPD1/LAPTM5/HLA-DPA1/CD14/HLA-DRB1/HLA-DPB1/C1QBP/PYCARD/SLC11A1/LILRB4/HRAS/LILRB1 16 GO:0002920 regulation of humoral immune response 9/1165 45/18722 0.00157095181388912 0.0152292789833499 CD59/PTPRC/C1QBP/CD55/A2M/CD46/PTPN6/TREM2/PHB 9 GO:0035272 exocrine system development 9/1165 45/18722 0.00157095181388912 0.0152292789833499 LAMA5/BMP7/WLS/DAG1/TFCP2L1/NRP1/TGM2/TGFB1/IGF2 9 GO:0009749 response to glucose 25/1165 212/18722 0.00158867925520765 0.0153745804473802 CTSV/LRP5/LDHA/GJA1/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/RHOA/SOX4/SLC29A1/TXNIP/TREM2/CCDC186/TXN2/BAD/GLUL/NME1/FIS1/SLC8A1/LRP1/ENSA 25 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 10/1165 54/18722 0.00162881975692724 0.0157359127291439 TEAD1/GATA3/KLF5/FOS/SPI1/KLF4/GNL3/TGFB1/LILRB4/JUN 10 GO:0002679 respiratory burst involved in defense response 5/1165 15/18722 0.00164165678162791 0.0158055223246612 NCF1/PRDX2/TREM2/HCK/GRN 5 GO:0140374 antiviral innate immune response 5/1165 15/18722 0.00164165678162791 0.0158055223246612 MX1/OAS1/PHB/IFIT1/CXCL10 5 GO:0000305 response to oxygen radical 7/1165 29/18722 0.00164926585520541 0.015851591173404 BMP7/SOD3/SOD2/SOD1/PRDX2/PRDX1/GCH1 7 GO:0006753 nucleoside phosphate metabolic process 48/1165 497/18722 0.00166796729463655 0.0160039323500769 ACSS1/SLC26A2/TYMP/LDHA/APP/ALDOA/QPRT/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/REXO2/VCP/RHOA/UPP1/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/PARK7/ENO1/SLC25A13/KYNU/BAD/TYMS/SLC25A1/NUDT5/NME1/IMPDH2/DNPH1/PARP9/PNP/DUT 48 GO:0044106 cellular amine metabolic process 16/1165 113/18722 0.00167591743113963 0.0160527722542436 ALDH7A1/GATA3/EPAS1/SMS/COMT/AKR1B1/OAZ1/SRM/IL4I1/PNKD/ATP2B4/PARK7/KYNU/CLN3/GCH1/SLC7A7 16 GO:0072088 nephron epithelium morphogenesis 12/1165 73/18722 0.00171895037926572 0.0164369139332513 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/STAT1/DLG1/VEGFA 12 GO:0002687 positive regulation of leukocyte migration 18/1165 135/18722 0.00178615077748113 0.0170504495136081 JAM3/APP/AIF1/PTN/LGMN/RHOA/VEGFA/C1QBP/LGALS3/SPI1/CD74/PYCARD/TREM2/GPSM3/CALR/CXCL10/CCL4/ADAM8 18 GO:0046628 positive regulation of insulin receptor signaling pathway 6/1165 22/18722 0.00180248148312031 0.0171189992635437 SORBS1/PRKCZ/NUCKS1/IGF2/GNAI2/SORL1 6 GO:0050860 negative regulation of T cell receptor signaling pathway 6/1165 22/18722 0.00180248148312031 0.0171189992635437 PAWR/LAPTM5/GBP1/LGALS3/PTPN6/LILRB4 6 GO:0060713 labyrinthine layer morphogenesis 6/1165 22/18722 0.00180248148312031 0.0171189992635437 BMP7/SPINT1/SPINT2/GRB2/ZFP36L1/SOCS3 6 GO:0006749 glutathione metabolic process 11/1165 64/18722 0.0018272260153205 0.0172954799730083 CLIC3/SOD1/GSTA4/GCLM/IDH1/GPX1/GSTP1/ARL6IP5/GPX4/GSTO1/PARK7 11 GO:0030888 regulation of B cell proliferation 11/1165 64/18722 0.0018272260153205 0.0172954799730083 TYROBP/SLC39A10/TFRC/PAWR/PTPRC/VAV3/CD74/TNFSF13B/MNDA/CD300A/LYN 11 GO:0002286 T cell activation involved in immune response 16/1165 114/18722 0.00183954251149026 0.0173367765846133 GATA3/PRKCZ/FCER1G/HLA-DRA/FGL2/LCP1/HLA-DRB1/LGALS3/CD86/EIF2AK4/CD46/CD74/SLC11A1/APBB1IP/LILRB1/HLA-DMB 16 GO:0051047 positive regulation of secretion 33/1165 310/18722 0.00184213765007646 0.0173367765846133 EGFR/MYH10/WLS/SLC6A4/GJA1/ISL1/EXPH5/SYT7/FRMD4A/CYBA/PTGES/SCIN/KCNN4/MPC2/HLA-F/S100A8/HLA-DRB1/SOX4/SERP1/TGFB1/TREM2/RETN/BAD/PPIA/FGR/TLR2/GNAI2/GLUL/CD2AP/SYK/ADAM8/LRP1/JAK2 33 GO:0071241 cellular response to inorganic substance 26/1165 226/18722 0.00184666900920451 0.0173367765846133 CDH1/EGFR/HSD17B1/B2M/SERPINF1/APP/TFAP2A/SYT7/ANK3/PARP1/SOD1/CYBB/NCF1/FBP1/LGMN/HSPA5/FOS/MTR/FUS/JUNB/CALR/BAD/TSPO/BNIP3/JUN/CCNB1 26 GO:0031294 lymphocyte costimulation 9/1165 46/18722 0.0018470323174058 0.0173367765846133 DPP4/CD24/YES1/CD86/PTPN6/TNFSF13B/LILRB2/LILRB4/LYN 9 GO:1900271 regulation of long-term synaptic potentiation 9/1165 46/18722 0.0018470323174058 0.0173367765846133 MME/NSG1/TYROBP/APP/APOE/PTN/LGMN/EIF2AK4/LILRB2 9 GO:0038066 p38MAPK cascade 10/1165 55/18722 0.00188177481170313 0.0176040033634827 NCF1/DUSP1/ZFP36/DLG1/VEGFA/SPI1/GADD45G/TREM2/ZFP36L1/PRMT1 10 GO:0061614 pri-miRNA transcription by RNA polymerase II 10/1165 55/18722 0.00188177481170313 0.0176040033634827 TEAD1/GATA3/KLF5/FOS/SPI1/KLF4/GNL3/TGFB1/LILRB4/JUN 10 GO:0009259 ribonucleotide metabolic process 39/1165 385/18722 0.00188588031304475 0.0176130552364728 ACSS1/SLC26A2/LDHA/APP/ALDOA/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/VCP/RHOA/UPP1/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/ENO1/SLC25A13/KYNU/BAD/SLC25A1/NME1/IMPDH2/PNP 39 GO:0009152 purine ribonucleotide biosynthetic process 21/1165 169/18722 0.00191363627459733 0.0178425920420512 ACSS1/SLC26A2/ALDOA/TMSB4X/PARP1/MPC2/VCP/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/SLC25A1/NME1/IMPDH2 21 GO:0010822 positive regulation of mitochondrion organization 12/1165 74/18722 0.00193785364271716 0.0180085637360454 PMAIP1/SLC25A5/PLAUR/TNFSF10/PYCARD/NMT1/TREM2/PARK7/BAD/FIS1/BNIP3/VDAC1 12 GO:1903201 regulation of oxidative stress-induced cell death 12/1165 74/18722 0.00193785364271716 0.0180085637360454 MET/PAGE4/SOD2/PARP1/SOD1/PAWR/P4HB/GPX1/STK26/TREM2/PARK7/PPIA 12 GO:0030316 osteoclast differentiation 14/1165 94/18722 0.00196654717926706 0.0182450071359108 FBN1/TYROBP/TFRC/GPC3/SNX10/CEBPB/FOS/ESRRA/JUNB/TREM2/LILRB4/OSCAR/LILRB1/LILRB3 14 GO:0006970 response to osmotic stress 13/1165 84/18722 0.00197859708164312 0.018326510592843 EGFR/SLC2A1/MAP7/HSP90AB1/MARVELD3/AKR1B1/TSC22D3/BAD/NFAT5/CLN3/TSPO/ZFP36L1/AQP9 13 GO:0071675 regulation of mononuclear cell migration 16/1165 115/18722 0.00201632498132726 0.018645192949242 APP/AIF1/DUSP1/LGMN/RHOA/C1QBP/LGALS3/SPI1/PYCARD/MSN/CALR/WASL/CXCL10/CCL4/ADAM8/LYN 16 GO:0030098 lymphocyte differentiation 38/1165 374/18722 0.00203002095917277 0.0187150408302418 PBX1/CTSL/B2M/GATA3/PRKCZ/GLI3/SOD1/FCER1G/PRDX2/HLA-DRA/FGL2/ITGB1/HLA-DRB1/PRKDC/RHOA/PTPRC/SLC25A5/IL4I1/SOX4/SPI1/CD86/IRF1/CD46/CD74/PTPN6/TNFSF13B/LILRB2/LILRB4/RSAD2/KLF6/BAD/DOCK10/KDELR1/ZFP36L1/SYK/ADAM8/PNP/CD83 38 GO:0044788 modulation by host of viral process 7/1165 30/18722 0.00203721538344517 0.0187150408302418 APOE/PPIB/PSMC3/EIF2AK4/NUCKS1/PHB/HSPA8 7 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 7/1165 30/18722 0.00203721538344517 0.0187150408302418 PAWR/LAPTM5/GBP1/LGALS3/PTPN6/LILRB4/CD300A 7 GO:1902751 positive regulation of cell cycle G2/M phase transition 7/1165 30/18722 0.00203721538344517 0.0187150408302418 PBX1/APP/BRD4/NPM1/CCND1/RAB11A/CCNB1 7 GO:0060562 epithelial tube morphogenesis 34/1165 325/18722 0.002116829397056 0.0194146460877048 LRP2/LAMA5/LGR5/MET/MAGED1/PBX1/BMP7/SPINT1/LGR4/LRP5/DAG1/DLG5/TACSTD2/SPINT2/CXCR4/FOLR1/LMO4/GATA3/GLI3/IRX2/GPC3/TBX3/YAP1/NRP1/CTSH/DLG1/RHOA/VEGFA/PRKACB/SOX4/TGFB1/RPS7/VASP/CXCL10 34 GO:0032868 response to insulin 29/1165 264/18722 0.00212073778154592 0.0194187621008438 KANK1/SLC2A1/SORBS1/PRKCZ/PARP1/IGF1R/GGH/SLC9A1/CCND3/STAT1/ATP2B1/FOXO4/PRKDC/GSTP1/GRB2/PIK3C2A/ESRRA/TNFSF10/NUCKS1/PKM/RETN/IGF2/PTPRA/TLR2/GNAI2/ZFP36L1/SOCS3/SORL1/LYN 29 GO:0009260 ribonucleotide biosynthetic process 22/1165 182/18722 0.00215515316738104 0.019668274834783 ACSS1/SLC26A2/ALDOA/TMSB4X/PARP1/MPC2/VCP/UPP1/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/SLC25A1/NME1/IMPDH2 22 GO:0097028 dendritic cell differentiation 9/1165 47/18722 0.00216054867867184 0.019668274834783 HLA-B/ITGB8/CEBPB/SPI1/TREM2/LILRB2/TMEM176B/LILRB1/LYN 9 GO:0002886 regulation of myeloid leukocyte mediated immunity 10/1165 56/18722 0.00216550754461 0.019668274834783 TYROBP/HLA-E/STXBP2/DHX36/SPI1/DDX1/FGR/SYK/CD300A/LYN 10 GO:0031529 ruffle organization 10/1165 56/18722 0.00216550754461 0.019668274834783 KANK1/TACSTD2/LIMA1/SNX10/AIF1/SH3YL1/EPS8/HRAS/RHOG/ABI3 10 GO:0043388 positive regulation of DNA binding 10/1165 56/18722 0.00216550754461 0.019668274834783 ISL1/GATA3/PARP1/PLAUR/KLF4/TGFB1/PARK7/NME1/LAMTOR5/JAK2 10 GO:0036473 cell death in response to oxidative stress 14/1165 95/18722 0.00217735356179852 0.0197277049701877 MET/PAGE4/SOD2/PARP1/SOD1/PAWR/P4HB/GPX1/STK26/ARL6IP5/TREM2/PARK7/PPIA/JAK2 14 GO:0061333 renal tubule morphogenesis 12/1165 75/18722 0.00217908018555431 0.0197277049701877 LAMA5/LGR5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/DLG1/VEGFA 12 GO:0034612 response to tumor necrosis factor 28/1165 253/18722 0.00224723897330597 0.0203120005751472 KRT18/KRT8/GATA3/TMSB4X/CYBA/LAPTM5/ASS1/GBP2/KLF2/NFKBIA/ZFP36/STAT1/GBP1/CD14/CCL3L3/GSTP1/CIB1/PYCARD/TNFSF13B/LIMS1/CXCL16/CCL4/GCH1/ZFP36L1/RPS3/SYK/JAK2/TNFRSF1B 28 GO:0002830 positive regulation of type 2 immune response 5/1165 16/18722 0.00226649963962901 0.0203876001237783 GATA3/PRKCZ/CD86/CD74/RSAD2 5 GO:0002921 negative regulation of humoral immune response 5/1165 16/18722 0.00226649963962901 0.0203876001237783 CD59/CD55/A2M/CD46/PTPN6 5 GO:0045838 positive regulation of membrane potential 5/1165 16/18722 0.00226649963962901 0.0203876001237783 ANK3/VCP/STOML2/GLRX/BAD 5 GO:0032273 positive regulation of protein polymerization 18/1165 138/18722 0.00228755620885141 0.0205404530856668 MET/SCIN/HSP90AA1/DLG1/RHOA/CLIP1/ARPC3/GMFG/GRB2/ARPC5L/AKAP9/PYCARD/WASF2/HCK/VASP/WASL/IQGAP2/RPS3 18 GO:0002758 innate immune response-activating signal transduction 6/1165 23/18722 0.0023117320421982 0.0205404530856668 TYROBP/FCN1/HCK/SYK/LILRA2/LYN 6 GO:0009162 deoxyribonucleoside monophosphate metabolic process 6/1165 23/18722 0.0023117320421982 0.0205404530856668 TYMP/UPP1/TYMS/DNPH1/PNP/DUT 6 GO:0018279 protein N-linked glycosylation via asparagine 6/1165 23/18722 0.0023117320421982 0.0205404530856668 TUSC3/DDOST/RPN2/FUT8/OSTC/MGAT1 6 GO:0042026 protein refolding 6/1165 23/18722 0.0023117320421982 0.0205404530856668 B2M/HSPD1/ST13/HSP90AA1/HSPA5/HSPA8 6 GO:0002765 immune response-inhibiting signal transduction 4/1165 10/18722 0.00231276792270469 0.0205404530856668 LILRB2/LILRB4/LILRB1/LYN 4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 4/1165 10/18722 0.00231276792270469 0.0205404530856668 PRDX4/P4HB/ERO1A/P4HA1 4 GO:0040015 negative regulation of multicellular organism growth 4/1165 10/18722 0.00231276792270469 0.0205404530856668 ADRB1/LGMN/PLAC8/GDF15 4 GO:0002221 pattern recognition receptor signaling pathway 21/1165 172/18722 0.0023767665371547 0.0210375977236957 LGR4/COLEC12/CTSS/HSPD1/CYBA/FCN1/NFKBIA/CD14/CLEC4E/C1QBP/IRF1/TREM2/IRF7/OAS1/RSAD2/PHB/OASL/TLR2/CD300A/LILRA2/LYN 21 GO:0006839 mitochondrial transport 28/1165 254/18722 0.0023799883403789 0.0210375977236957 HSPD1/LMAN1/SLC9A1/SLC25A3/BNIP3L/HSP90AA1/MPC2/SLC25A37/MRS2/PMAIP1/HEBP2/SLC25A5/AFG3L2/PMPCB/TIMM13/SLC25A36/STOML2/NMT1/SFXN4/SLC25A13/BAD/SLC25A1/ROMO1/FIS1/TSPO/BNIP3/TIMM8B/VDAC1 28 GO:0009165 nucleotide biosynthetic process 28/1165 254/18722 0.0023799883403789 0.0210375977236957 ACSS1/SLC26A2/ALDOA/QPRT/TMSB4X/PARP1/MPC2/VCP/UPP1/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/KYNU/TYMS/SLC25A1/NME1/IMPDH2/PARP9/PNP/DUT 28 GO:0009123 nucleoside monophosphate metabolic process 12/1165 76/18722 0.00244428813248403 0.0215043719241894 TYMP/DLG1/UPP1/PAICS/ATIC/AK3/ADK/TYMS/IMPDH2/DNPH1/PNP/DUT 12 GO:0031100 animal organ regeneration 12/1165 76/18722 0.00244428813248403 0.0215043719241894 EGFR/TGFBR3/GLI3/ANXA3/LCP1/CEBPB/GSTP1/CCND1/ATIC/RPS16/TYMS/SULF2 12 GO:0032543 mitochondrial translation 12/1165 76/18722 0.00244428813248403 0.0215043719241894 IARS2/MRPS21/C1QBP/MRPS15/MRPL51/MRPS34/MRPL52/LRPPRC/MRPS6/UQCC2/MRPS7/MRPL43 12 GO:0001952 regulation of cell-matrix adhesion 17/1165 128/18722 0.00246328061912643 0.0216375494759885 DAG1/FERMT1/PRKCZ/CDK6/RASA1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/CIB1/LIMS1/PTPRA/RRAS/UTRN/LRP1 17 GO:0045066 regulatory T cell differentiation 7/1165 31/18722 0.00249210965827905 0.0217884914515893 HLA-DRA/HLA-DRB1/IL4I1/IRF1/CD46/LILRB2/LILRB4 7 GO:0090183 regulation of kidney development 7/1165 31/18722 0.00249210965827905 0.0217884914515893 MAGED1/LGR4/TACSTD2/GATA3/STAT1/VEGFA/BASP1 7 GO:1900027 regulation of ruffle assembly 7/1165 31/18722 0.00249210965827905 0.0217884914515893 KANK1/TACSTD2/SH3YL1/EPS8/HRAS/RHOG/ABI3 7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 9/1165 48/18722 0.00251498821768522 0.0219543217198556 TIMP3/ITM2C/TNFRSF12A/PMAIP1/PTPRC/SKIL/TNFSF10/PYCARD/PEA15 9 GO:0001763 morphogenesis of a branching structure 23/1165 196/18722 0.00254807236650995 0.0222085872565533 LAMA5/MET/MAGED1/PBX1/BMP7/SPINT1/LGR4/LRP5/DAG1/DLG5/TACSTD2/SPINT2/GLI3/GPC3/TBX3/YAP1/NRP1/CTSH/DLG1/TGM2/VEGFA/GRB2/SOCS3 23 GO:0009314 response to radiation 44/1165 456/18722 0.00258868840503945 0.0225276093294363 EGFR/MME/LRP5/ADIRF/SOD2/APP/GATA3/TIMP1/PARP1/CYBA/NR2F6/DDB1/YAP1/NET1/DUSP1/NPM1/ITGB1/PTN/GPX1/GNA11/HSPA5/FOS/PRKDC/PTPRC/DNMT3A/DHX36/UBE4B/GRB2/EIF2AK4/CRIP1/CCND1/SLC1A3/NUCKS1/MDM2/OPN3/NMT1/HRAS/USP47/CXCL10/IFI16/BABAM1/JUN/HMGN1/CIRBP 44 GO:0009308 amine metabolic process 16/1165 118/18722 0.00263382878233995 0.0228559238999929 ALDH7A1/GATA3/EPAS1/SMS/COMT/AKR1B1/OAZ1/SRM/IL4I1/PNKD/ATP2B4/PARK7/KYNU/CLN3/GCH1/SLC7A7 16 GO:0001701 in utero embryonic development 37/1165 367/18722 0.00263455955162932 0.0228559238999929 NR2F2/BMP7/SPINT1/KRT8/PHLDA2/SPINT2/GATA3/GLI3/AMOT/EPAS1/TBX3/YAP1/NASP/KLF2/ITGB1/CEBPB/FUT8/SLC39A1/VEGFA/SKIL/GRB2/KLF4/JUNB/NMT1/KRT19/EIF2S2/RTF1/SF3B6/IGF2/YBX1/PSMC4/ZFP36L1/PRMT1/SCO2/SOCS3/MGAT1/CCNB1 37 GO:0120162 positive regulation of cold-induced thermogenesis 14/1165 97/18722 0.00265513627000999 0.0229988887092069 ADRB1/GJA1/CXCR4/EPAS1/ESRRG/IGF1R/PRLR/GNAS/CEBPB/VEGFA/PLAC8/GADD45G/SYK/JAK2 14 GO:0042130 negative regulation of T cell proliferation 11/1165 67/18722 0.00266416095951657 0.0230192134792341 DLG5/PAWR/CEBPB/DLG1/HLA-DRB1/IL4I1/CD86/PTPN6/LILRB2/LILRB4/LILRB1 11 GO:1901293 nucleoside phosphate biosynthetic process 28/1165 256/18722 0.00266568479627688 0.0230192134792341 ACSS1/SLC26A2/ALDOA/QPRT/TMSB4X/PARP1/MPC2/VCP/UPP1/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/KYNU/TYMS/SLC25A1/NME1/IMPDH2/PARP9/PNP/DUT 28 GO:2000177 regulation of neural precursor cell proliferation 13/1165 87/18722 0.00272427287460701 0.0234890071354365 LRP2/ADGRG1/SPINT1/SLC6A4/SPINT2/GLI3/ASPM/PTN/RHOA/VEGFA/FLNA/GNAI2/LYN 13 GO:0010959 regulation of metal ion transport 40/1165 406/18722 0.0027452703289207 0.0236337459451409 GJA1/B2M/FXYD3/CXCR4/ANK3/CYBA/PRSS8/TSPAN13/KCNN4/SLC9A1/KCNG1/ITGB1/ATP2B1/DLG1/FXYD5/RHOA/FLNA/C4orf3/LGALS3/CAMK2G/ATP2B4/AKAP9/PTPN6/GSTO1/TREM2/LILRB2/GLRX/VMP1/LILRB1/GNAI2/CXCL10/YWHAE/CCL4/ISCU/TSPO/SLC8A1/UTRN/VDAC1/LILRA2/LYN 40 GO:0043467 regulation of generation of precursor metabolites and energy 17/1165 130/18722 0.00290561215564575 0.0247761287092343 PHLDA2/SORBS1/APP/FBP1/VCP/RHOA/CISD1/OPN3/PARK7/UQCC2/IGF2/COX7A2/ISCU/BNIP3/IL10RB/NDUFA4/CCNB1 17 GO:0030225 macrophage differentiation 9/1165 49/18722 0.00291398608709314 0.0247761287092343 APP/PARP1/C1QC/HLA-DRB1/VEGFA/EIF2AK1/SPI1/TGFB1/TLR2 9 GO:0045778 positive regulation of ossification 9/1165 49/18722 0.00291398608709314 0.0247761287092343 FBN2/BMP7/ISG15/TFAP2A/PTN/ATP2B1/TGFB1/SLC8A1/ATRAID 9 GO:0052372 modulation by symbiont of entry into host 9/1165 49/18722 0.00291398608709314 0.0247761287092343 IFITM3/FCN1/P4HB/HLA-DRB1/IFITM2/CD74/TRIM22/FUCA2/SNX3 9 GO:0072091 regulation of stem cell proliferation 9/1165 49/18722 0.00291398608709314 0.0247761287092343 FBLN1/FERMT1/GJA1/FERMT2/TBX3/YAP1/CCNE1/PTPRC/ZFP36L1 9 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 6/1165 24/18722 0.00292210889105882 0.0247761287092343 HLA-B/HLA-A/HLA-E/HLA-F/PTPRC/LILRB1 6 GO:0002726 positive regulation of T cell cytokine production 6/1165 24/18722 0.00292210889105882 0.0247761287092343 HLA-A/B2M/GATA3/PRKCZ/CD55/RSAD2 6 GO:0018196 peptidyl-asparagine modification 6/1165 24/18722 0.00292210889105882 0.0247761287092343 TUSC3/DDOST/RPN2/FUT8/OSTC/MGAT1 6 GO:0035458 cellular response to interferon-beta 6/1165 24/18722 0.00292210889105882 0.0247761287092343 STAT1/IFITM2/IRF1/OAS1/MNDA/IFI16 6 GO:2000679 positive regulation of transcription regulatory region DNA binding 6/1165 24/18722 0.00292210889105882 0.0247761287092343 GATA3/PARP1/KLF4/TGFB1/PARK7/LAMTOR5 6 GO:0031668 cellular response to extracellular stimulus 27/1165 246/18722 0.00299396191241654 0.025347071213264 CTSV/SLC2A1/FOLR1/AIF1/COMT/PTN/SESN1/ATP2B1/PMAIP1/SKP2/HSPA5/FOS/PTPRC/GSTP1/UPP1/EIF2AK4/STK26/MDM2/CD68/TXN2/GLUL/ASGR1/IFI16/HSPA8/JUN/GABARAPL1/LYN 27 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 11/1165 68/18722 0.00300344440249918 0.0253508773401923 ALDOA/TMSB4X/PARP1/VCP/TGFB1/STOML2/TREM2/ENO1/SLC25A13/NME1/IMPDH2 11 GO:0046637 regulation of alpha-beta T cell differentiation 11/1165 68/18722 0.00300344440249918 0.0253508773401923 GATA3/PRKCZ/GLI3/HLA-DRA/HLA-DRB1/RHOA/CD86/LILRB4/SYK/PNP/CD83 11 GO:0050685 positive regulation of mRNA processing 7/1165 32/18722 0.00302123169763604 0.0254245480042445 DHX36/PRDX6/NCL/RBM3/HSPA8/CIRBP/CCNB1 7 GO:0072337 modified amino acid transport 7/1165 32/18722 0.00302123169763604 0.0254245480042445 LRP2/SLC16A12/GJA1/FOLR1/SLC19A1/SLC13A3/SLC5A6 7 GO:0097067 cellular response to thyroid hormone stimulus 5/1165 17/18722 0.00304795961942068 0.0256110738679764 CTSL/CTSS/CTSH/GCLM/LMO2 5 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 12/1165 78/18722 0.0030536145188862 0.0256202366136147 HSPD1/LAPTM5/HSPE1/CTSH/PMAIP1/VCP/S100A8/PYCARD/BAD/CYCS/PDCD6/JAK2 12 GO:0006163 purine nucleotide metabolic process 39/1165 396/18722 0.00309825846083238 0.0259560070756002 ACSS1/SLC26A2/LDHA/APP/ALDOA/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/VCP/RHOA/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/ENO1/SLC25A13/KYNU/BAD/SLC25A1/NME1/IMPDH2/DNPH1/PNP 39 GO:0071901 negative regulation of protein serine/threonine kinase activity 16/1165 120/18722 0.00312687050304927 0.0261566678593376 NR2F2/BMP7/LRP5/CDKN1C/PKIB/DUSP1/APOE/PDCD4/LATS2/GSTP1/PYCARD/PTPN6/SLC8A1/SORL1/CD300A/LYN 16 GO:0050729 positive regulation of inflammatory response 18/1165 142/18722 0.00313498490346139 0.0261757729497149 EGFR/APP/HSPD1/HLA-E/NFKBIA/PDCD4/CEBPB/S100A8/TGM2/IL6ST/TREM2/PARK7/GPSM3/S100A12/TLR2/ADAM8/JAK2/GRN 18 GO:0050728 negative regulation of inflammatory response 21/1165 176/18722 0.00313848123911601 0.0261757729497149 ISL1/SERPINF1/GATA3/SOD1/APOE/YES1/ZFP36/GPX1/HLA-DRB1/PTPRC/GSTP1/KLF4/TREM2/HCK/FGR/SOCS3/SYK/TNFRSF1B/PSMB4/GRN/LYN 21 GO:0050920 regulation of chemotaxis 25/1165 223/18722 0.00316489607487266 0.0263431652118771 SEMA6A/SEMA6D/MET/DPP4/JAM3/CXCR4/TMSB4X/NRP1/AIF1/DUSP1/PTN/LGMN/VEGFA/C1QBP/GSTP1/SPI1/CD74/TGFB1/TREM2/USP14/GPSM3/CALR/CXCL10/CCL4/LYN 25 GO:0031098 stress-activated protein kinase signaling cascade 27/1165 247/18722 0.00316793809335775 0.0263431652118771 EGFR/PAGE4/HACD3/DUSP9/APP/MARVELD3/IGF1R/NCF1/DUSP1/PDCD4/PRDX1/ZFP36/AKR1B1/DLG1/RHOA/VEGFA/GSTP1/SPI1/PYCARD/ARL6IP5/GADD45G/TREM2/HRAS/PPIA/ZFP36L1/PRMT1/LYN 27 GO:0051258 protein polymerization 31/1165 296/18722 0.00318892684759463 0.0264784709993323 KANK1/MET/TMSB4X/KANK4/RASA1/SCIN/TMSB10/AIF1/COTL1/HSP90AA1/DLG1/RHOA/CLIP1/ARPC3/EPS8/GMFG/GRB2/ARPC5L/AKAP9/PYCARD/WASF2/GPX4/TRIOBP/HCK/STMN1/VASP/WASL/ADD3/IQGAP2/RPS3/JAK2 31 GO:0006767 water-soluble vitamin metabolic process 10/1165 59/18722 0.00322827886248389 0.0267261493438379 SLC2A1/SLC19A3/FOLR1/SLC19A1/SLC52A1/MTR/SLC2A3/GSTO1/AASDHPPT/MMADHC 10 GO:0090303 positive regulation of wound healing 10/1165 59/18722 0.00322827886248389 0.0267261493438379 KANK1/CLDN4/FERMT1/CXCR4/FERMT2/PLPP3/PRDX2/ITGB1/ST3GAL4/HRAS 10 GO:0046661 male sex differentiation 20/1165 165/18722 0.00323997019718953 0.0267834355181515 LRP2/ADGRG1/CTSV/LGR4/GATA3/PRDX4/RHOBTB3/ASPM/ARID5B/DHCR24/TBX3/NASP/TFAP2C/UBB/FLNA/CCND1/TNFSF10/EIF2S2/SF1/LHFPL2 20 GO:0009306 protein secretion 36/1165 359/18722 0.00326003234974385 0.0268701344774042 EGFR/MYH10/DPP4/WLS/LRP5/GJA1/ISL1/EXPH5/FAM3B/SYT7/FRMD4A/KCNN4/APOE/MPC2/HLA-DRB1/HMGN3/PDIA4/SOX4/CAMK2G/SERP1/TGFB1/TREM2/PARK7/UQCC2/CCDC186/RSAD2/BAD/PPIA/TLR2/GLUL/ERP29/CD2AP/ADAM8/LRP1/JAK2/ENSA 36 GO:2000146 negative regulation of cell motility 36/1165 359/18722 0.00326003234974385 0.0268701344774042 CDH1/SEMA6D/ADGRG1/KANK1/NR2F2/FBLN1/TCAF1/DPP4/DAG1/GJA1/DLG5/TACSTD2/SPINT2/SERPINF1/GATA3/TIMP1/MARVELD3/AIF1/DUSP1/APOE/PTN/RHOA/GSTP1/KLF4/ATP2B4/CD74/STK26/TGFB1/ARHGDIB/CALR/RRAS/WASL/BST2/APEX1/LRP1/CD300A 36 GO:0051962 positive regulation of nervous system development 29/1165 272/18722 0.00328916940412643 0.0270705393920259 LRP2/EGFR/SPINT1/MME/DAG1/DLG5/CXCR4/SERPINF1/GLI3/ASPM/OBSL1/NRP1/PTN/GOLGA4/TGM2/VEGFA/ETV5/SKIL/DHX36/IL6ST/TGFB1/HDAC2/UFL1/TLR2/TSPO/RAB11A/LRP1/TNFRSF1B/LYN 29 GO:0071902 positive regulation of protein serine/threonine kinase activity 23/1165 200/18722 0.00329432578342163 0.0270732805598032 EGFR/MAGED1/HSP90AB1/CD24/FERMT2/FLT1/CCND3/RHOA/VEGFA/CCND1/ATP2B4/CIB1/TGFB1/CKS2/HRAS/IGF2/S100A12/CKS1B/ERP29/RPS3/SYK/ADAM8/CCNB1 23 GO:0006469 negative regulation of protein kinase activity 24/1165 212/18722 0.00333634205980226 0.027378491201272 NR2F2/BMP7/LRP5/CDKN1C/PKIB/MLLT1/DUSP1/NPM1/APOE/PDCD4/PTPRC/LATS2/GSTP1/PYCARD/PTPN6/VPS25/PARK7/LILRB4/PPIA/SNX6/SLC8A1/SORL1/CD300A/LYN 24 GO:0043405 regulation of MAP kinase activity 21/1165 177/18722 0.00335799047792339 0.0274629833396495 EGFR/MAGED1/BMP7/CD24/FLT1/DUSP1/APOE/PDCD4/VEGFA/GSTP1/PTPN6/TGFB1/HRAS/S100A12/ERP29/RPS3/SYK/ADAM8/SORL1/CD300A/LYN 21 GO:0038093 Fc receptor signaling pathway 9/1165 50/18722 0.00336131650709767 0.0274629833396495 FCER1G/YES1/PTPRC/VAV3/HCK/MYO1G/FGR/SYK/LYN 9 GO:2000677 regulation of transcription regulatory region DNA binding 9/1165 50/18722 0.00336131650709767 0.0274629833396495 GATA3/TMSB4X/PARP1/MSX2/KLF4/TGFB1/PARK7/ZNF593/LAMTOR5 9 GO:0045665 negative regulation of neuron differentiation 11/1165 69/18722 0.00337661692826726 0.0275478936313433 PBX1/BMP7/SLC6A4/ISL1/B2M/APP/GLI3/ASPM/RHOA/EIF2AK4/CALR 11 GO:0002224 toll-like receptor signaling pathway 16/1165 121/18722 0.00340058351068775 0.0277031571052109 LGR4/COLEC12/CTSS/HSPD1/CYBA/NFKBIA/CD14/IRF1/TREM2/IRF7/OAS1/RSAD2/TLR2/CD300A/LILRA2/LYN 16 GO:0007569 cell aging 17/1165 132/18722 0.00341196447476661 0.0277152578728457 MME/B2M/CDK6/SOD1/PAWR/TBX3/NPM1/PDCD4/PRKDC/SPI1/LIMS1/HRAS/CALR/YBX1/ROMO1/ABI3/YPEL3 17 GO:0035592 establishment of protein localization to extracellular region 36/1165 360/18722 0.00341205322173884 0.0277152578728457 EGFR/MYH10/DPP4/WLS/LRP5/GJA1/ISL1/EXPH5/FAM3B/SYT7/FRMD4A/KCNN4/APOE/MPC2/HLA-DRB1/HMGN3/PDIA4/SOX4/CAMK2G/SERP1/TGFB1/TREM2/PARK7/UQCC2/CCDC186/RSAD2/BAD/PPIA/TLR2/GLUL/ERP29/CD2AP/ADAM8/LRP1/JAK2/ENSA 36 GO:0002604 regulation of dendritic cell antigen processing and presentation 4/1165 11/18722 0.00345638348672581 0.0277152578728457 FGL2/CD74/SLC11A1/CD68 4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 4/1165 11/18722 0.00345638348672581 0.0277152578728457 UQCRQ/UQCR10/CYCS/UQCR11 4 GO:0035581 sequestering of extracellular ligand from receptor 4/1165 11/18722 0.00345638348672581 0.0277152578728457 FBN1/FBN2/LTBP1/CD46 4 GO:0043312 neutrophil degranulation 4/1165 11/18722 0.00345638348672581 0.0277152578728457 ANXA3/STXBP2/SPI1/SYK 4 GO:0045657 positive regulation of monocyte differentiation 4/1165 11/18722 0.00345638348672581 0.0277152578728457 HLA-DRB1/CD74/ZFP36L1/JUN 4 GO:0046643 regulation of gamma-delta T cell activation 4/1165 11/18722 0.00345638348672581 0.0277152578728457 PTPRC/SOX4/LILRB1/SYK 4 GO:0048102 autophagic cell death 4/1165 11/18722 0.00345638348672581 0.0277152578728457 CTSV/LAPTM5/TREM2/BNIP3 4 GO:0048680 positive regulation of axon regeneration 4/1165 11/18722 0.00345638348672581 0.0277152578728457 PTN/FLNA/LRP1/GRN 4 GO:0098883 synapse pruning 4/1165 11/18722 0.00345638348672581 0.0277152578728457 C1QA/C1QB/C1QC/TREM2 4 GO:1902904 negative regulation of supramolecular fiber organization 20/1165 166/18722 0.00347428989937055 0.0278191001500241 KANK1/MET/TACSTD2/TMSB4X/KANK4/TJP1/SCIN/TMSB10/LIMA1/APOE/EPS8/GMFG/PFDN5/CIB1/WASF2/TREM2/TRIOBP/STMN1/ADD3/HSPA8 20 GO:0042558 pteridine-containing compound metabolic process 7/1165 33/18722 0.0036321099192441 0.0289588536601096 FOLR1/SLC19A1/GGH/MTR/ATIC/TYMS/GCH1 7 GO:1903715 regulation of aerobic respiration 7/1165 33/18722 0.0036321099192441 0.0289588536601096 VCP/RHOA/PARK7/UQCC2/COX7A2/ISCU/BNIP3 7 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 7/1165 33/18722 0.0036321099192441 0.0289588536601096 EGFR/HSP90AB1/CCND3/CCND1/CKS2/CKS1B/CCNB1 7 GO:0048143 astrocyte activation 6/1165 25/18722 0.00364532046238362 0.0289818466789791 EGFR/APP/C1QA/TREM2/LRP1/GRN 6 GO:1903901 negative regulation of viral life cycle 6/1165 25/18722 0.00364532046238362 0.0289818466789791 IFITM3/FCN1/IFITM2/PPIA/BST2/SNX3 6 GO:0031663 lipopolysaccharide-mediated signaling pathway 10/1165 60/18722 0.0036625657197254 0.0290366968712128 PRDX2/NFKBIA/CD14/CD55/SPI1/TGFB1/HCK/TLR2/LILRA2/LYN 10 GO:0051851 modulation by host of symbiont process 10/1165 60/18722 0.0036625657197254 0.0290366968712128 APOE/PPIB/PSMC3/TAF11/EIF2AK4/NUCKS1/PHB/CCL4/HSPA8/JUN 10 GO:0046390 ribose phosphate biosynthetic process 22/1165 190/18722 0.00367479696267678 0.0290925745437303 ACSS1/SLC26A2/ALDOA/TMSB4X/PARP1/MPC2/VCP/UPP1/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/SLC25A1/NME1/IMPDH2 22 GO:0035304 regulation of protein dephosphorylation 13/1165 90/18722 0.00368519463088613 0.029092823436236 SLC39A10/HSP90B1/HSP90AB1/PTPRC/LGALS3/TGFB1/LILRB2/PPIA/GNAI2/YWHAE/CD300A/JAK2/ENSA 13 GO:0045638 negative regulation of myeloid cell differentiation 13/1165 90/18722 0.00368519463088613 0.029092823436236 FBN1/CDK6/NFKBIA/ZFP36/C1QC/CIB1/LILRB4/LILRB1/NME1/ZFP36L1/LILRB3/PRMT1/LYN 13 GO:0042254 ribosome biogenesis 31/1165 299/18722 0.0037085938669047 0.0291954240882694 RPS17/RPS21/RPSA/MRPL1/RPS27/NPM1/RPLP0/PRKDC/C1QBP/SURF6/RPS28/RPS5/SNU13/DDX27/RAN/MRPL20/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/BRIX1/RPS7/NHP2/RPS16/MRPS7/GLUL/NOP56/IMP3/RPL10A 31 GO:1901990 regulation of mitotic cell cycle phase transition 31/1165 299/18722 0.0037085938669047 0.0291954240882694 EGFR/PBX1/ADAMTS1/CTDSPL/APP/WEE1/DDB1/AIF1/DUSP1/BRD4/CCND3/PSME2/DLG1/FOXO4/PRKDC/SOX4/CCND1/KLF4/BRD7/PTPN6/ANAPC11/MDM2/CENPF/USP47/PSME1/RAD21/APEX1/BABAM1/ZFP36L1/RAB11A/CCNB1 31 GO:0000082 G1/S transition of mitotic cell cycle 24/1165 214/18722 0.00376365013756296 0.0295873504511777 EGFR/ADAMTS1/CTDSPL/CDK6/WEE1/NASP/AIF1/BRD4/CCND3/ITGB1/PSME2/DLG1/SKP2/PRKDC/CCNE1/SOX4/LATS2/CCND1/KLF4/BRD7/PTPN6/MDM2/PSME1/APEX1 24 GO:0009791 post-embryonic development 12/1165 80/18722 0.00378041129887588 0.0296361014254055 FBN1/EFEMP1/GATA3/ARID5B/MYO7A/VEGFA/ATF5/SERP1/KLF4/CCDC47/C12orf57/HMGN1 12 GO:0071229 cellular response to acid chemical 12/1165 80/18722 0.00378041129887588 0.0296361014254055 SLC38A9/CYBA/ASS1/CYBB/KLF2/GCLM/SESN1/DNMT1/CEBPB/VEGFA/DNMT3A/LAMTOR5 12 GO:0046596 regulation of viral entry into host cell 8/1165 42/18722 0.00389118629865133 0.0304619647061784 IFITM3/FCN1/P4HB/HLA-DRB1/IFITM2/CD74/TRIM22/SNX3 8 GO:0044282 small molecule catabolic process 37/1165 376/18722 0.00394779315444209 0.0308620654260215 SLC27A2/GLDC/LRP5/QPRT/GCSH/APOBEC3A/ECHDC2/ADH5/APOE/ECHS1/TPI1/ALDH2/CDO1/FUT8/PCCB/IL4I1/AIG1/UPP1/PNKD/ECI1/ECI2/ATP2B4/ETFA/ECH1/PARK7/ENO1/KYNU/HADHB/BAD/GLUL/NUDT5/MGAT1/PNP/ACADVL/GK/ECHDC1/NPL 37 GO:0032869 cellular response to insulin stimulus 23/1165 203/18722 0.00396772024099662 0.0309747061372935 KANK1/SORBS1/PRKCZ/PARP1/IGF1R/SLC9A1/CCND3/STAT1/ATP2B1/FOXO4/PRKDC/GSTP1/GRB2/PIK3C2A/ESRRA/NUCKS1/PKM/IGF2/PTPRA/GNAI2/ZFP36L1/SOCS3/SORL1 23 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 5/1165 18/18722 0.00400649460954079 0.0310678239414075 PTPRC/CD55/CD46/PTPN6/TREM2 5 GO:0030889 negative regulation of B cell proliferation 5/1165 18/18722 0.00400649460954079 0.0310678239414075 TYROBP/PAWR/MNDA/CD300A/LYN 5 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 5/1165 18/18722 0.00400649460954079 0.0310678239414075 HLA-B/HLA-A/HLA-E/HLA-F/LILRB1 5 GO:0060391 positive regulation of SMAD protein signal transduction 5/1165 18/18722 0.00400649460954079 0.0310678239414075 PARP1/RBPMS/DAB2/TGFB1/JAK2 5 GO:0050852 T cell receptor signaling pathway 16/1165 123/18722 0.00400732309523945 0.0310678239414075 HLA-A/GATA3/PAWR/LAPTM5/KCNN4/GBP1/HLA-DRB1/HLA-DPB1/PTPRC/LGALS3/PTPN6/STOML2/LILRB4/HRAS/RPS3/CD300A 16 GO:0061564 axon development 44/1165 467/18722 0.00402007705475402 0.0311237138045991 SEMA6A/LAMA5/SEMA6D/BMP7/DAG1/EPHB4/JAM3/ISL1/APP/NRP2/FOLR1/GATA3/ANK3/GLI3/HSP90AB1/EFNA1/S100A6/NRP1/SIAH1/PARD6B/NREP/APOE/HSP90AA1/ITGB1/BSG/PTN/GOLGA4/DLX5/VEGFA/FLNA/SKIL/AFG3L2/MTR/KLF4/STMN1/VASP/C12orf57/RHOG/ACTB/TSPO/RAB11A/LRP1/JAK2/GRN 44 GO:0045936 negative regulation of phosphate metabolic process 42/1165 441/18722 0.00403420751503603 0.0311900919860844 NR2F2/FBLN1/BMP7/LRP5/CTDSPL/CDKN1C/PKIB/PRKCZ/PARP1/MLLT1/PLPP3/DUSP1/NPM1/APOE/PDCD4/FBP1/PRKDC/PTPRC/LATS2/GSTP1/LGALS3/APOC1/CIB1/PYCARD/PTPN6/TGFB1/VPS25/PRDX3/PARK7/LILRB4/PPIA/GNAI2/SNX6/YWHAE/SLC8A1/SOCS3/LRP1/SORL1/CD300A/CCNB1/ENSA/LYN 42 GO:0030198 extracellular matrix organization 31/1165 301/18722 0.00409356032036991 0.0315620248327421 COL14A1/ADAMTS6/VWA1/COL4A2/CCDC80/LAMB1/FBLN1/ADAMTS1/DPP4/CTSV/SPINT1/DAG1/FERMT1/SERPINH1/LAMC1/SMOC1/ADAMTSL4/SPINT2/CTSS/APP/PRDX4/ITGB1/LCP1/CST3/TGFB1/ERO1A/P4HA1/SULF2/ADAM8/LRP1/TNFRSF1B 31 GO:0042886 amide transport 31/1165 301/18722 0.00409356032036991 0.0315620248327421 LRP2/EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/FOLR1/SLC19A1/SYT7/SLC13A3/MPC2/S100A8/HLA-DRB1/HMGN3/SOX4/SLC5A6/CAMK2G/SERP1/CD74/TAP1/PARK7/UQCC2/CCDC186/BAD/GLUL/TAPBP/LRP1/JAK2/AQP9/ENSA 31 GO:0072521 purine-containing compound metabolic process 40/1165 416/18722 0.00419188683882593 0.0322758036026474 ACSS1/SLC26A2/LDHA/APP/ALDOA/TMSB4X/PARP1/GAPDH/HINT1/NUDT4/TPST2/FBP1/MPC2/TPI1/DLG1/VCP/RHOA/PAICS/TECR/RAN/ATIC/AK3/PGK1/DLD/TGFB1/STOML2/ADK/PKM/TREM2/PMVK/ENO1/SLC25A13/KYNU/BAD/SLC25A1/OARD1/NME1/IMPDH2/DNPH1/PNP 40 GO:0010563 negative regulation of phosphorus metabolic process 42/1165 442/18722 0.00419829032259807 0.0322808268229356 NR2F2/FBLN1/BMP7/LRP5/CTDSPL/CDKN1C/PKIB/PRKCZ/PARP1/MLLT1/PLPP3/DUSP1/NPM1/APOE/PDCD4/FBP1/PRKDC/PTPRC/LATS2/GSTP1/LGALS3/APOC1/CIB1/PYCARD/PTPN6/TGFB1/VPS25/PRDX3/PARK7/LILRB4/PPIA/GNAI2/SNX6/YWHAE/SLC8A1/SOCS3/LRP1/SORL1/CD300A/CCNB1/ENSA/LYN 42 GO:0072078 nephron tubule morphogenesis 11/1165 71/18722 0.00423414535690114 0.0324329988414866 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/DLG1/VEGFA 11 GO:1902106 negative regulation of leukocyte differentiation 14/1165 102/18722 0.00423541566912697 0.0324329988414866 FBN1/CDK6/GLI3/PRDX2/FGL2/C1QC/IRF1/CD74/LILRB4/TMEM176B/LILRB1/NME1/LILRB3/LYN 14 GO:1990542 mitochondrial transmembrane transport 14/1165 102/18722 0.00423541566912697 0.0324329988414866 HSPD1/SLC25A3/MPC2/SLC25A37/MRS2/SLC25A5/AFG3L2/SLC25A36/STOML2/SFXN4/SLC25A13/SLC25A1/ROMO1/VDAC1 14 GO:0043062 extracellular structure organization 31/1165 302/18722 0.00429838594487572 0.0328703546438521 COL14A1/ADAMTS6/VWA1/COL4A2/CCDC80/LAMB1/FBLN1/ADAMTS1/DPP4/CTSV/SPINT1/DAG1/FERMT1/SERPINH1/LAMC1/SMOC1/ADAMTSL4/SPINT2/CTSS/APP/PRDX4/ITGB1/LCP1/CST3/TGFB1/ERO1A/P4HA1/SULF2/ADAM8/LRP1/TNFRSF1B 31 GO:0007431 salivary gland development 7/1165 34/18722 0.00433247654686888 0.0330145547560095 LAMA5/BMP7/DAG1/TFCP2L1/NRP1/TGM2/TGFB1 7 GO:0055094 response to lipoprotein particle 7/1165 34/18722 0.00433247654686888 0.0330145547560095 FCER1G/APOE/ITGB1/CD9/CD68/TREM2/SYK 7 GO:0040013 negative regulation of locomotion 38/1165 391/18722 0.00433488809107056 0.0330145547560095 CDH1/SEMA6A/SEMA6D/ADGRG1/KANK1/NR2F2/FBLN1/TCAF1/DPP4/DAG1/GJA1/DLG5/TACSTD2/SPINT2/SERPINF1/GATA3/TIMP1/MARVELD3/NRP1/AIF1/DUSP1/APOE/PTN/RHOA/GSTP1/KLF4/ATP2B4/CD74/STK26/TGFB1/ARHGDIB/CALR/RRAS/WASL/BST2/APEX1/LRP1/CD300A 38 GO:0043392 negative regulation of DNA binding 9/1165 52/18722 0.0044167072317338 0.03359211069339 TMSB4X/MSX2/NFKBIA/ID1/HDAC2/ZNF593/IFI16/JUN/JAK2 9 GO:0071356 cellular response to tumor necrosis factor 25/1165 229/18722 0.00447938382926372 0.0339530736237555 KRT18/KRT8/GATA3/TMSB4X/CYBA/LAPTM5/ASS1/GBP2/KLF2/NFKBIA/ZFP36/STAT1/GBP1/CCL3L3/GSTP1/CIB1/PYCARD/TNFSF13B/LIMS1/CCL4/ZFP36L1/RPS3/SYK/JAK2/TNFRSF1B 25 GO:0007596 blood coagulation 24/1165 217/18722 0.00449010104488684 0.0339530736237555 F5/FBLN1/SERPINA1/LMAN1/FCER1G/CD59/PRDX2/APOE/GNAS/VAV3/FLNA/PLAUR/CD9/PLSCR1/IL6ST/AK3/PTPN6/ST3GAL4/PPIA/ACTB/SYK/JAK2/TFPI2/LYN 24 GO:0006760 folic acid-containing compound metabolic process 6/1165 26/18722 0.00449329637682807 0.0339530736237555 FOLR1/SLC19A1/GGH/ATIC/TYMS/GCH1 6 GO:0097066 response to thyroid hormone 6/1165 26/18722 0.00449329637682807 0.0339530736237555 CTSL/CTSS/CTSH/GCLM/AKR1B1/LMO2 6 GO:0030900 forebrain development 37/1165 379/18722 0.00449441184793343 0.0339530736237555 LRP2/CDH1/ADGRG1/NR2F2/LAMB1/TACC2/SLC2A1/ISL1/B2M/GNG12/TYROBP/CXCR4/APP/NRP2/CDK6/GLI3/ASPM/UQCRQ/TBX3/ANXA3/NRP1/PTN/DLX5/RHOA/UBB/FLNA/ATF5/ATP2B4/ATIC/BCL2A1/C12orf57/BAD/PCM1/NME1/BNIP3/SLC8A1/LRP1 37 GO:0001910 regulation of leukocyte mediated cytotoxicity 12/1165 82/18722 0.0046402460135721 0.0349914663153612 HLA-B/HLA-A/B2M/TYROBP/CADM1/HLA-E/HLA-DRA/HLA-F/HLA-DRB1/PTPRC/SPI1/LILRB1 12 GO:0072073 kidney epithelium development 17/1165 136/18722 0.00464433322731945 0.0349914663153612 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/IRX2/GPC3/CD24/YAP1/STAT1/DLG1/PECAM1/VEGFA/BASP1 17 GO:0060675 ureteric bud morphogenesis 10/1165 62/18722 0.00466933033989762 0.0351326423563611 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA 10 GO:0002244 hematopoietic progenitor cell differentiation 15/1165 114/18722 0.00470003659733961 0.0353163392514956 JAM3/ZFAT/GATA3/FLT1/PRKDC/PTPRC/SOX4/DHX36/SPI1/PTPN6/TGFB1/PRRC2C/RBM47/UFL1/TOP2A 15 GO:0032729 positive regulation of interferon-gamma production 11/1165 72/18722 0.00472344067539537 0.0353974265834369 HLA-A/ISL1/ISG15/HSPD1/HLA-DPA1/CD14/HLA-DPB1/PYCARD/SLC11A1/HRAS/LILRB1 11 GO:0042273 ribosomal large subunit biogenesis 11/1165 72/18722 0.00472344067539537 0.0353974265834369 MRPL1/NPM1/RPLP0/SURF6/SNU13/MRPL20/RPL35/RPL5/BRIX1/NHP2/RPL10A 11 GO:0045229 external encapsulating structure organization 31/1165 304/18722 0.00473408724894301 0.0354299089710895 COL14A1/ADAMTS6/VWA1/COL4A2/CCDC80/LAMB1/FBLN1/ADAMTS1/DPP4/CTSV/SPINT1/DAG1/FERMT1/SERPINH1/LAMC1/SMOC1/ADAMTSL4/SPINT2/CTSS/APP/PRDX4/ITGB1/LCP1/CST3/TGFB1/ERO1A/P4HA1/SULF2/ADAM8/LRP1/TNFRSF1B 31 GO:0001933 negative regulation of protein phosphorylation 34/1165 342/18722 0.00476175833100754 0.0355895466204332 NR2F2/FBLN1/BMP7/LRP5/CTDSPL/CDKN1C/PKIB/PRKCZ/MLLT1/PLPP3/DUSP1/NPM1/APOE/PDCD4/PRKDC/PTPRC/LATS2/GSTP1/CIB1/PYCARD/PTPN6/TGFB1/VPS25/PARK7/LILRB4/PPIA/SNX6/SLC8A1/SOCS3/LRP1/SORL1/CD300A/CCNB1/LYN 34 GO:0010632 regulation of epithelial cell migration 30/1165 292/18722 0.00485269919762548 0.0360877444126073 MET/NR2F2/TACSTD2/SERPINF1/NRP2/GATA3/TMSB4X/MARVELD3/ANXA3/PLPP3/EFNA1/NRP1/APOE/CTSH/PTN/LGMN/RHOA/VEGFA/RAB25/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/RAB11A/PDCD6/GRN 30 GO:0010212 response to ionizing radiation 18/1165 148/18722 0.00488311685845643 0.0360877444126073 GATA3/PARP1/CYBA/YAP1/NET1/GPX1/HSPA5/PRKDC/PTPRC/DNMT3A/GRB2/CCND1/NUCKS1/MDM2/HRAS/CXCL10/IFI16/BABAM1 18 GO:1901992 positive regulation of mitotic cell cycle phase transition 13/1165 93/18722 0.00490389023479937 0.0360877444126073 EGFR/PBX1/ADAMTS1/APP/AIF1/BRD4/CCND3/CCND1/ANAPC11/MDM2/APEX1/RAB11A/CCNB1 13 GO:0002424 T cell mediated immune response to tumor cell 4/1165 12/18722 0.00493128451175304 0.0360877444126073 HLA-A/HSPD1/HLA-DRB1/IL4I1 4 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 4/1165 12/18722 0.00493128451175304 0.0360877444126073 TYMP/UPP1/TYMS/DUT 4 GO:0009886 post-embryonic animal morphogenesis 4/1165 12/18722 0.00493128451175304 0.0360877444126073 FBN1/EFEMP1/MYO7A/HMGN1 4 GO:0043129 surfactant homeostasis 4/1165 12/18722 0.00493128451175304 0.0360877444126073 EPAS1/CTSH/VEGFA/OAS1 4 GO:0043380 regulation of memory T cell differentiation 4/1165 12/18722 0.00493128451175304 0.0360877444126073 HLA-DRA/FGL2/HLA-DRB1/CD46 4 GO:0045916 negative regulation of complement activation 4/1165 12/18722 0.00493128451175304 0.0360877444126073 CD59/CD55/A2M/CD46 4 GO:0070493 thrombin-activated receptor signaling pathway 4/1165 12/18722 0.00493128451175304 0.0360877444126073 MET/HPGD/STMN1/IQGAP2 4 GO:0070572 positive regulation of neuron projection regeneration 4/1165 12/18722 0.00493128451175304 0.0360877444126073 PTN/FLNA/LRP1/GRN 4 GO:0072182 regulation of nephron tubule epithelial cell differentiation 4/1165 12/18722 0.00493128451175304 0.0360877444126073 GATA3/CD24/YAP1/STAT1 4 GO:0098911 regulation of ventricular cardiac muscle cell action potential 4/1165 12/18722 0.00493128451175304 0.0360877444126073 DSP/DSG2/DSC2/DLG1 4 GO:1902563 regulation of neutrophil activation 4/1165 12/18722 0.00493128451175304 0.0360877444126073 SPI1/SYK/CD300A/GRN 4 GO:1903599 positive regulation of autophagy of mitochondrion 4/1165 12/18722 0.00493128451175304 0.0360877444126073 SLC25A5/PARK7/BNIP3/VDAC1 4 GO:1905245 regulation of aspartic-type peptidase activity 4/1165 12/18722 0.00493128451175304 0.0360877444126073 EFNA1/SORL1/GRN/LYN 4 GO:0045732 positive regulation of protein catabolic process 25/1165 231/18722 0.00500814792697324 0.0366025186381521 LRP2/GJA1/LAPTM5/GPC3/DDB1/APOE/HSP90AA1/MAGEF1/OAZ1/VCP/DAB2/BAG2/PSMC1/PSMC3/MYLIP/PSMC6/MSN/MDM2/TREM2/WWP1/PSMC4/ADAM8/LRP1/SORL1/TNFRSF1B 25 GO:0071320 cellular response to cAMP 9/1165 53/18722 0.00503291791332588 0.0367357194375789 APP/ASS1/HSPA5/AKAP9/FDX1/APEX1/ZFP36L1/SLC8A1/AQP9 9 GO:0031397 negative regulation of protein ubiquitination 12/1165 83/18722 0.00512516923667497 0.0371498895907567 ISG15/RPL23/BAG2/SOX4/RPL5/RPL37/PARK7/RPS7/PPIA/UFL1/TSPO/RPS3 12 GO:0001893 maternal placenta development 7/1165 35/18722 0.0051302239886897 0.0371498895907567 NR2F2/CTSV/GJA1/BSG/PTN/JUNB/PRDX3 7 GO:0097421 liver regeneration 7/1165 35/18722 0.0051302239886897 0.0371498895907567 EGFR/GLI3/CEBPB/CCND1/RPS16/TYMS/SULF2 7 GO:2000403 positive regulation of lymphocyte migration 7/1165 35/18722 0.0051302239886897 0.0371498895907567 APP/AIF1/RHOA/PYCARD/CXCL10/CCL4/ADAM8 7 GO:0002716 negative regulation of natural killer cell mediated immunity 5/1165 19/18722 0.00516246461442904 0.0371498895907567 HLA-B/HLA-A/HLA-E/HLA-F/LILRB1 5 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 5/1165 19/18722 0.00516246461442904 0.0371498895907567 TYROBP/HLA-E/DHX36/SPI1/DDX1 5 GO:0030050 vesicle transport along actin filament 5/1165 19/18722 0.00516246461442904 0.0371498895907567 MYO7A/FNBP1L/MYO1G/WASL/MYO1F 5 GO:0032026 response to magnesium ion 5/1165 19/18722 0.00516246461442904 0.0371498895907567 ANK3/FBP1/CD14/CCND1/MDM2 5 GO:0035461 vitamin transmembrane transport 5/1165 19/18722 0.00516246461442904 0.0371498895907567 LRP2/SLC19A3/FOLR1/SLC19A1/SLC5A6 5 GO:0044827 modulation by host of viral genome replication 5/1165 19/18722 0.00516246461442904 0.0371498895907567 PPIB/EIF2AK4/NUCKS1/PHB/HSPA8 5 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 5/1165 19/18722 0.00516246461442904 0.0371498895907567 HLA-A/HLA-E/IRF1/LILRB4/LILRB1 5 GO:0048736 appendage development 20/1165 172/18722 0.00519585523484261 0.0372945465897334 FBN2/NR2F2/ITGB4/PBX1/BMP7/ITGA6/LRP5/FRAS1/SMOC1/ZNRF3/TFAP2A/GLI3/GPC3/FERMT2/TBX3/IRF6/DLX5/SLC39A1/SOX4/HDAC2 20 GO:0060173 limb development 20/1165 172/18722 0.00519585523484261 0.0372945465897334 FBN2/NR2F2/ITGB4/PBX1/BMP7/ITGA6/LRP5/FRAS1/SMOC1/ZNRF3/TFAP2A/GLI3/GPC3/FERMT2/TBX3/IRF6/DLX5/SLC39A1/SOX4/HDAC2 20 GO:0009126 purine nucleoside monophosphate metabolic process 8/1165 44/18722 0.00523531666311032 0.0374901000130255 DLG1/PAICS/ATIC/AK3/ADK/IMPDH2/DNPH1/PNP 8 GO:0009411 response to UV 18/1165 149/18722 0.00524033086606946 0.0374901000130255 EGFR/MME/TIMP1/PARP1/DDB1/NPM1/PTN/GPX1/DHX36/UBE4B/EIF2AK4/CRIP1/CCND1/MDM2/OPN3/USP47/HMGN1/CIRBP 18 GO:0072171 mesonephric tubule morphogenesis 10/1165 63/18722 0.00524816710230738 0.0374901000130255 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA 10 GO:0032732 positive regulation of interleukin-1 production 11/1165 73/18722 0.00525649540535384 0.0374901000130255 ISL1/TYROBP/APP/S100A13/PYCARD/GBP5/HDAC2/MNDA/IFI16/JAK2/LILRA2 11 GO:0072089 stem cell proliferation 11/1165 73/18722 0.00525649540535384 0.0374901000130255 FBLN1/FERMT1/RNF43/GJA1/ZNRF3/FERMT2/TBX3/YAP1/CCNE1/PTPRC/ZFP36L1 11 GO:0010594 regulation of endothelial cell migration 25/1165 232/18722 0.00529143914133186 0.0376914313455529 MET/NR2F2/SERPINF1/NRP2/GATA3/TMSB4X/ANXA3/PLPP3/EFNA1/NRP1/APOE/PTN/LGMN/RHOA/VEGFA/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/CALR/RRAS/GLUL/PDCD6/GRN 25 GO:0002064 epithelial cell development 24/1165 220/18722 0.0053300325456196 0.0379182163226398 MET/EXPH5/ADAMTSL4/SPINT2/CXCR4/TFCP2L1/CDK6/SOD1/TJP1/YAP1/KLF5/MYO7A/AKR1B1/GPX1/PECAM1/VEGFA/RAB25/FLNA/VIM/IL6ST/MSN/TRIOBP/BAD/TYMS 24 GO:0019080 viral gene expression 13/1165 94/18722 0.00537531566346507 0.0381919579987714 IFITM3/ZFP36/FUT8/PSMC3/TAF11/EIF2AK4/NUCKS1/EIF3A/ST3GAL4/CCL4/JUN/MGAT1/PARP9 13 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 6/1165 27/18722 0.00547808760770485 0.0386878469525023 PBX1/APP/BRD4/CCND1/RAB11A/CCNB1 6 GO:0032703 negative regulation of interleukin-2 production 6/1165 27/18722 0.00547808760770485 0.0386878469525023 GATA3/LAPTM5/ZFP36/GBP1/PTPRC/LILRB4 6 GO:0060142 regulation of syncytium formation by plasma membrane fusion 6/1165 27/18722 0.00547808760770485 0.0386878469525023 TYROBP/GDF15/TREM2/PLEKHO1/CD53/CXCL10 6 GO:0098901 regulation of cardiac muscle cell action potential 6/1165 27/18722 0.00547808760770485 0.0386878469525023 GJA5/DSP/DSG2/DSC2/DLG1/AKAP9 6 GO:1903532 positive regulation of secretion by cell 29/1165 282/18722 0.00547957212314971 0.0386878469525023 EGFR/MYH10/WLS/SLC6A4/GJA1/ISL1/EXPH5/SYT7/FRMD4A/PTGES/KCNN4/MPC2/HLA-F/HLA-DRB1/SOX4/SERP1/TGFB1/TREM2/RETN/BAD/PPIA/FGR/TLR2/GLUL/CD2AP/SYK/ADAM8/LRP1/JAK2 29 GO:0006694 steroid biosynthetic process 20/1165 173/18722 0.00554161736005272 0.0390767565853969 HSD17B1/SLC27A2/PBX1/SOD1/DHCR24/PRLR/FDFT1/APOE/AKR1B1/FDPS/HINT2/OSBPL9/PMVK/CYB5R1/FDX1/HSD17B11/SF1/ACBD3/TSPO/CGA 20 GO:0007160 cell-matrix adhesion 25/1165 233/18722 0.00558793615531975 0.0393539343034 BCAM/ITGB4/DAG1/FERMT1/JAM3/SORBS1/CD44/PRKCZ/CDK6/ITGB5/RASA1/FERMT2/S100A10/NRP1/SLC9A1/ITGB1/RHOA/VEGFA/CIB1/TRIP6/LIMS1/PTPRA/RRAS/UTRN/LRP1 25 GO:0044772 mitotic cell cycle phase transition 40/1165 424/18722 0.00577663314378448 0.0406190629099486 EGFR/PBX1/ADAMTS1/CTDSPL/APP/CDK6/WEE1/DDB1/NASP/AIF1/DUSP1/BRD4/CCND3/ITGB1/PSME2/DLG1/SKP2/FOXO4/PRKDC/CCNE1/SOX4/LATS2/EPS8/CCND1/KLF4/BRD7/PTPN6/ANAPC11/MDM2/CKS2/CENPF/USP47/PSME1/RAD21/APEX1/BABAM1/ZFP36L1/RAB11A/CCNB1/ENSA 40 GO:0045786 negative regulation of cell cycle 37/1165 385/18722 0.00578204725905022 0.0406190629099486 EGFR/NR2F2/BMP7/CTDSPL/CDKN1C/GATA3/CDK6/BTG3/WEE1/DUSP1/NPM1/PDCD4/DLG1/FOXO4/PRKDC/AURKAIP1/PRKACB/HPGD/SOX4/LATS2/ATF5/EIF2AK4/CCND1/KLF4/BRD7/TGFB1/MDM2/CENPF/USP47/NAA10/LILRB1/GMNN/RAD21/BABAM1/ZFP36L1/CCNB1/NR4A1 37 GO:0051100 negative regulation of binding 19/1165 162/18722 0.00578973151016454 0.0406222037081919 B2M/TMSB4X/MSX2/NFKBIA/ID1/DAB2/BAG2/LRPAP1/C4orf3/IFIT2/PARK7/HDAC2/IFIT1/ZNF593/IFI16/ACTB/JUN/SORL1/JAK2 19 GO:0009201 ribonucleoside triphosphate biosynthetic process 11/1165 74/18722 0.00583594079248088 0.0408953004596694 ALDOA/TMSB4X/PARP1/VCP/TGFB1/STOML2/TREM2/ENO1/SLC25A13/NME1/IMPDH2 11 GO:1900076 regulation of cellular response to insulin stimulus 10/1165 64/18722 0.00588167471100865 0.0411643892180693 KANK1/SORBS1/PRKCZ/ATP2B1/ESRRA/NUCKS1/IGF2/GNAI2/SOCS3/SORL1 10 GO:0010639 negative regulation of organelle organization 34/1165 347/18722 0.00593803487625255 0.0415070856293967 KANK1/MET/BMP7/TACSTD2/TMSB4X/PARP1/TFRC/KANK4/TJP1/SCIN/TMSB10/LIMA1/YAP1/DUSP1/NPM1/GPX1/AURKAIP1/SLC25A5/EPS8/GMFG/CIB1/WASF2/RAD50/LILRB2/CENPF/TRIOBP/STMN1/NAA10/ADD3/RAD21/TSPO/BNIP3/TOP2A/CCNB1 34 GO:0007599 hemostasis 24/1165 222/18722 0.00595942055781596 0.041552451626665 F5/FBLN1/SERPINA1/LMAN1/FCER1G/CD59/PRDX2/APOE/GNAS/VAV3/FLNA/PLAUR/CD9/PLSCR1/IL6ST/AK3/PTPN6/ST3GAL4/PPIA/ACTB/SYK/JAK2/TFPI2/LYN 24 GO:0050817 coagulation 24/1165 222/18722 0.00595942055781596 0.041552451626665 F5/FBLN1/SERPINA1/LMAN1/FCER1G/CD59/PRDX2/APOE/GNAS/VAV3/FLNA/PLAUR/CD9/PLSCR1/IL6ST/AK3/PTPN6/ST3GAL4/PPIA/ACTB/SYK/JAK2/TFPI2/LYN 24 GO:0042116 macrophage activation 14/1165 106/18722 0.00598688159353926 0.041552451626665 TYROBP/APP/HSPD1/IFNGR2/AIF1/C1QA/PTPRC/CD74/SLC11A1/TREM2/TLR2/SYK/JAK2/GRN 14 GO:0046822 regulation of nucleocytoplasmic transport 14/1165 106/18722 0.00598688159353926 0.041552451626665 CDH1/FERMT1/PTPN14/GLI3/HSP90AB1/FLNA/MX2/RAN/TGFB1/MDM2/PARK7/YWHAE/JAK2/NUP214 14 GO:1903707 negative regulation of hemopoiesis 14/1165 106/18722 0.00598688159353926 0.041552451626665 FBN1/CDK6/GLI3/PRDX2/FGL2/C1QC/IRF1/CD74/LILRB4/TMEM176B/LILRB1/NME1/LILRB3/LYN 14 GO:0048754 branching morphogenesis of an epithelial tube 18/1165 151/18722 0.00601897108209915 0.041552451626665 LAMA5/MET/MAGED1/PBX1/BMP7/LGR4/LRP5/DAG1/DLG5/TACSTD2/GLI3/GPC3/TBX3/YAP1/NRP1/CTSH/DLG1/VEGFA 18 GO:0035307 positive regulation of protein dephosphorylation 8/1165 45/18722 0.00602761176564463 0.041552451626665 SLC39A10/HSP90AB1/PTPRC/TGFB1/LILRB2/PPIA/CD300A/JAK2 8 GO:0051180 vitamin transport 8/1165 45/18722 0.00602761176564463 0.041552451626665 LRP2/SLC2A1/SLC19A3/FOLR1/SLC19A1/SLC52A1/SLC5A6/SLC2A3 8 GO:0071364 cellular response to epidermal growth factor stimulus 8/1165 45/18722 0.00602761176564463 0.041552451626665 EGFR/ZFP36/ID1/GSTP1/MCM7/SNX6/NCL/ZFP36L1 8 GO:1904646 cellular response to amyloid-beta 8/1165 45/18722 0.00602761176564463 0.041552451626665 GJA1/APP/PARP1/IGF1R/LGMN/TREM2/SNX6/LRP1 8 GO:2000273 positive regulation of signaling receptor activity 8/1165 45/18722 0.00602761176564463 0.041552451626665 NRP1/IFNGR2/NCF1/ITGB1/NCOA3/PARK7/HDAC2/JAK2 8 GO:0071402 cellular response to lipoprotein particle stimulus 7/1165 36/18722 0.00603335971418706 0.041552451626665 FCER1G/APOE/ITGB1/CD9/CD68/TREM2/SYK 7 GO:0031333 negative regulation of protein-containing complex assembly 17/1165 140/18722 0.00621946388075322 0.0427816798562106 KANK1/JAM3/ISL1/LMO4/PRKCZ/TMSB4X/KANK4/SCIN/TMSB10/HSPA5/EPS8/TREM2/PARK7/TRIOBP/STMN1/ADD3/SORL1 17 GO:0061136 regulation of proteasomal protein catabolic process 21/1165 187/18722 0.00634816690202682 0.043613538336691 HSP90AB1/APOE/PSMD14/PSME2/GPX1/VCP/DAB2/BAG2/UBB/PITHD1/PSMC1/PSMC3/PSMC6/MDM2/TREM2/USP14/PARK7/RAD23B/PSMC4/UFL1/PSME1 21 GO:0031532 actin cytoskeleton reorganization 14/1165 107/18722 0.00650478852255406 0.0446349364023177 NRK/TJP1/NRP1/RHOA/FLNA/EPS8/GMFG/GRB2/HCK/ARHGDIB/HRAS/ABI3/IQGAP2/CD2AP 14 GO:0060252 positive regulation of glial cell proliferation 5/1165 20/18722 0.00653587869815656 0.0447610319638334 EGFR/ETV5/UFL1/TSPO/LYN 5 GO:0043410 positive regulation of MAPK cascade 44/1165 480/18722 0.0065391138803391 0.0447610319638334 EGFR/MAGED1/APP/CD44/PRKCZ/SOD1/LAPTM5/CD24/FERMT2/FLT1/IGF1R/EFNA1/NRP1/NCF1/PRDX2/APOE/HLA-DRB1/VEGFA/PTPRC/CCL3L3/SPI1/CD74/CIB1/PYCARD/ARL6IP5/GADD45G/TGFB1/GDF15/TREM2/MYDGF/HRAS/NENF/IGF2/PHB/PPIA/S100A12/GNAI2/CCL4/PRMT1/ERP29/RPS3/SYK/ADAM8/LRP1 44 GO:0061082 myeloid leukocyte cytokine production 6/1165 28/18722 0.00661176718577798 0.0451482350532504 LAPTM5/DHX36/DDX1/CD74/TGFB1/LILRB1 6 GO:0090200 positive regulation of release of cytochrome c from mitochondria 6/1165 28/18722 0.00661176718577798 0.0451482350532504 PMAIP1/PLAUR/TNFSF10/PYCARD/BAD/BNIP3 6 GO:2001234 negative regulation of apoptotic signaling pathway 24/1165 224/18722 0.00664905681622797 0.0453476985534478 ITGA6/SOD2/CD44/YAP1/NRP1/PRDX2/HELLS/GCLM/GPX1/SIAH2/SLC25A5/IFI6/GSTP1/LGALS3/PLAUR/CD74/MDM2/PARK7/ENO1/USP47/PPIA/GNAI2/NDUFS3/PEA15 24 GO:0035296 regulation of tube diameter 17/1165 141/18722 0.006674289238665 0.0453544618603228 EGFR/GJA5/SLC6A4/ADRB1/SOD3/GJA1/SOD2/SOD1/KLF2/APOE/GCLM/ATP2B1/GPX1/RHOA/PIK3C2A/GCH1/SLC8A1 17 GO:0050921 positive regulation of chemotaxis 17/1165 141/18722 0.006674289238665 0.0453544618603228 MET/CXCR4/TMSB4X/NRP1/AIF1/PTN/LGMN/VEGFA/C1QBP/SPI1/CD74/TGFB1/TREM2/GPSM3/CALR/CXCL10/CCL4 17 GO:0097746 blood vessel diameter maintenance 17/1165 141/18722 0.006674289238665 0.0453544618603228 EGFR/GJA5/SLC6A4/ADRB1/SOD3/GJA1/SOD2/SOD1/KLF2/APOE/GCLM/ATP2B1/GPX1/RHOA/PIK3C2A/GCH1/SLC8A1 17 GO:0072522 purine-containing compound biosynthetic process 22/1165 200/18722 0.00674404894389013 0.0454390862601565 ACSS1/SLC26A2/ALDOA/TMSB4X/PARP1/MPC2/VCP/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/SLC25A1/NME1/IMPDH2/PNP 22 GO:0042541 hemoglobin biosynthetic process 4/1165 13/18722 0.00677579105643167 0.0454390862601565 SLC25A37/EIF2AK1/KLF4/PRMT1 4 GO:0042769 DNA damage response, detection of DNA damage 4/1165 13/18722 0.00677579105643167 0.0454390862601565 PARP1/SOX4/MRPS26/RPS3 4 GO:0043379 memory T cell differentiation 4/1165 13/18722 0.00677579105643167 0.0454390862601565 HLA-DRA/FGL2/HLA-DRB1/CD46 4 GO:0044794 positive regulation by host of viral process 4/1165 13/18722 0.00677579105643167 0.0454390862601565 APOE/PPIB/NUCKS1/HSPA8 4 GO:0060670 branching involved in labyrinthine layer morphogenesis 4/1165 13/18722 0.00677579105643167 0.0454390862601565 SPINT1/SPINT2/GRB2/SOCS3 4 GO:0070486 leukocyte aggregation 4/1165 13/18722 0.00677579105643167 0.0454390862601565 BMP7/CD44/S100A8/MSN 4 GO:0071801 regulation of podosome assembly 4/1165 13/18722 0.00677579105643167 0.0454390862601565 LCP1/RHOA/MSN/HCK 4 GO:1900272 negative regulation of long-term synaptic potentiation 4/1165 13/18722 0.00677579105643167 0.0454390862601565 TYROBP/APP/APOE/PTN 4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/1165 13/18722 0.00677579105643167 0.0454390862601565 TIMP3/PMAIP1/SKIL/PEA15 4 GO:1903054 negative regulation of extracellular matrix organization 4/1165 13/18722 0.00677579105643167 0.0454390862601565 DPP4/CST3/TGFB1/TNFRSF1B 4 GO:0019318 hexose metabolic process 25/1165 237/18722 0.00691533061023505 0.0462643035938609 LRP5/PHLDA2/SORBS1/ALDOA/SLC35B4/DDB1/GAPDH/FBP1/AKR1B1/TPI1/PMAIP1/FUT8/PGP/FUCA1/DCXR/SERP1/PGK1/ENO1/OAS1/SLC25A13/IGF2/BAD/SLC25A1/FAM3C/FUCA2 25 GO:0033673 negative regulation of kinase activity 25/1165 237/18722 0.00691533061023505 0.0462643035938609 NR2F2/BMP7/LRP5/CDKN1C/PKIB/MLLT1/DUSP1/NPM1/APOE/PDCD4/PTPRC/LATS2/GSTP1/PYCARD/PTPN6/VPS25/PRDX3/PARK7/LILRB4/PPIA/SNX6/SLC8A1/SORL1/CD300A/LYN 25 GO:0030282 bone mineralization 15/1165 119/18722 0.00700092110920521 0.0467811549832962 FBN2/SRGN/BMP7/LGR4/ISG15/TFAP2A/NOTUM/GPC3/SNX10/PTN/ATP2B1/TGFB1/FGR/SLC8A1/ATRAID 15 GO:0140053 mitochondrial gene expression 14/1165 108/18722 0.00705786899819974 0.0471056108048694 IARS2/MRPS21/TFAM/C1QBP/MRPS15/MRPL51/MRPS34/MRPL52/LRPPRC/MRPS6/UQCC2/MRPL12/MRPS7/MRPL43 14 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 11/1165 76/18722 0.00714480111460309 0.047475859537095 CD44/PERP/PHLDA3/HINT1/PMAIP1/UBB/CD74/PYCARD/MDM2/RPS7/IFI16 11 GO:0086001 cardiac muscle cell action potential 11/1165 76/18722 0.00714480111460309 0.047475859537095 GJA5/DSP/DSG2/GJA1/ANK3/DSC2/DLG1/FLNA/AKAP9/YWHAE/SLC8A1 11 GO:0035150 regulation of tube size 17/1165 142/18722 0.0071556346282527 0.047475859537095 EGFR/GJA5/SLC6A4/ADRB1/SOD3/GJA1/SOD2/SOD1/KLF2/APOE/GCLM/ATP2B1/GPX1/RHOA/PIK3C2A/GCH1/SLC8A1 17 GO:0046546 development of primary male sexual characteristics 17/1165 142/18722 0.0071556346282527 0.047475859537095 LRP2/ADGRG1/CTSV/GATA3/PRDX4/RHOBTB3/ASPM/ARID5B/NASP/TFAP2C/UBB/FLNA/CCND1/TNFSF10/EIF2S2/SF1/LHFPL2 17 GO:2000045 regulation of G1/S transition of mitotic cell cycle 17/1165 142/18722 0.0071556346282527 0.047475859537095 EGFR/ADAMTS1/CTDSPL/WEE1/AIF1/CCND3/PSME2/DLG1/PRKDC/SOX4/CCND1/KLF4/BRD7/PTPN6/MDM2/PSME1/APEX1 17 GO:0051960 regulation of nervous system development 41/1165 443/18722 0.00722321917121982 0.0478676850154154 LRP2/SEMA6A/EGFR/SEMA6D/BMP7/SPINT1/MME/TYMP/DAG1/DLG5/B2M/CXCR4/SERPINF1/GLI3/ASPM/OBSL1/YAP1/NRP1/PTN/ID1/DLG1/GOLGA4/TGM2/VEGFA/ETV5/SKIL/DHX36/IL6ST/TGFB1/BHLHE41/TREM2/HDAC2/UFL1/PCM1/TLR2/TSPO/RAB11A/LRP1/SORL1/TNFRSF1B/LYN 41 GO:0001658 branching involved in ureteric bud morphogenesis 9/1165 56/18722 0.00728648335282993 0.0480599659922849 LAMA5/MAGED1/PBX1/LGR4/TACSTD2/GLI3/GPC3/DLG1/VEGFA 9 GO:0010518 positive regulation of phospholipase activity 9/1165 56/18722 0.00728648335282993 0.0480599659922849 EGFR/PRKCZ/FLT1/CD86/HRAS/ARF4/PHB/ARL1/S1PR4 9 GO:0032608 interferon-beta production 9/1165 56/18722 0.00728648335282993 0.0480599659922849 ISG15/HSP90AA1/IRF1/PYCARD/IRF7/OAS1/OAS2/TLR2/LILRB1 9 GO:0032648 regulation of interferon-beta production 9/1165 56/18722 0.00728648335282993 0.0480599659922849 ISG15/HSP90AA1/IRF1/PYCARD/IRF7/OAS1/OAS2/TLR2/LILRB1 9 GO:0051495 positive regulation of cytoskeleton organization 24/1165 226/18722 0.0074031410189631 0.0487721015721125 MET/FERMT2/SCIN/DSTN/S100A10/NRP1/ID1/DLG1/RHOA/CLIP1/ARPC3/FLNA/GMFG/GRB2/ARPC5L/AKAP9/PYCARD/WASF2/HCK/HRAS/VASP/WASL/IQGAP2/RPS3 24 GO:1903578 regulation of ATP metabolic process 12/1165 87/18722 0.00748200130205744 0.0492338491306546 APP/TMSB4X/PARP1/FBP1/VCP/RHOA/TREM2/UQCC2/ENO1/COX7A2/FIS1/TSPO 12 GO:0061337 cardiac conduction 13/1165 98/18722 0.0076353131052036 0.0501838553390021 GJA5/DSP/DSG2/GJA1/ISL1/DSC2/SLC9A1/ATP2B1/FLNA/ATP2B4/AKAP9/YWHAE/SLC8A1 13 GO:0021675 nerve development 11/1165 77/18722 0.00787973419304018 0.0516810110144568 CTSV/DAG1/ISL1/NRP2/TFAP2A/GLI3/ERBB3/NRP1/AFG3L2/SLC1A3/SULF2 11 GO:1900744 regulation of p38MAPK cascade 8/1165 47/18722 0.00788151530881437 0.0516810110144568 NCF1/DUSP1/DLG1/VEGFA/SPI1/GADD45G/TREM2/PRMT1 8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 6/1165 29/18722 0.00790633275027516 0.0517228971180588 EGFR/CCND3/CCND1/CKS2/CKS1B/CCNB1 6 GO:2000406 positive regulation of T cell migration 6/1165 29/18722 0.00790633275027516 0.0517228971180588 APP/AIF1/RHOA/PYCARD/CXCL10/ADAM8 6 GO:1903034 regulation of response to wounding 19/1165 167/18722 0.00797862905923918 0.0521350930262043 KANK1/CLDN4/FERMT1/GJA1/CXCR4/FERMT2/PLPP3/PRDX2/TNFRSF12A/APOE/ITGB1/PTN/FLNA/CD9/KLF4/ST3GAL4/HRAS/LRP1/GRN 19 GO:0006164 purine nucleotide biosynthetic process 21/1165 191/18722 0.00803736748911928 0.0524578415307285 ACSS1/SLC26A2/ALDOA/TMSB4X/PARP1/MPC2/VCP/PAICS/TECR/ATIC/AK3/DLD/TGFB1/STOML2/ADK/TREM2/ENO1/SLC25A13/SLC25A1/NME1/IMPDH2 21 GO:0042177 negative regulation of protein catabolic process 15/1165 121/18722 0.00814215503264075 0.052645979602315 EGFR/TIMP3/TIMP1/HSP90AB1/EFNA1/RPL23/FLNA/CST3/RPL5/USP14/PARK7/RPS7/PHB/SNX3/ATRAID 15 GO:0045931 positive regulation of mitotic cell cycle 15/1165 121/18722 0.00814215503264075 0.052645979602315 EGFR/PBX1/ADAMTS1/APP/AIF1/BRD4/CCND3/LGMN/USP22/CCND1/ANAPC11/MDM2/APEX1/RAB11A/CCNB1 15 GO:0010517 regulation of phospholipase activity 10/1165 67/18722 0.00814410262950858 0.052645979602315 EGFR/PRKCZ/FLT1/CD86/HRAS/ARF4/PHB/ARL1/S1PR4/LRP1 10 GO:0070527 platelet aggregation 10/1165 67/18722 0.00814410262950858 0.052645979602315 GNAS/FLNA/CD9/IL6ST/PTPN6/PPIA/ACTB/SYK/JAK2/LYN 10 GO:0032516 positive regulation of phosphoprotein phosphatase activity 5/1165 21/18722 0.00814616301646128 0.052645979602315 SLC39A10/HSP90AB1/PTPRC/CD300A/JAK2 5 GO:0046641 positive regulation of alpha-beta T cell proliferation 5/1165 21/18722 0.00814616301646128 0.052645979602315 HLA-A/HLA-E/PTPRC/CD55/SYK 5 GO:0060445 branching involved in salivary gland morphogenesis 5/1165 21/18722 0.00814616301646128 0.052645979602315 LAMA5/BMP7/DAG1/NRP1/TGM2 5 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 5/1165 21/18722 0.00814616301646128 0.052645979602315 LAPTM5/DHX36/DDX1/CD74/LILRB1 5 GO:0006754 ATP biosynthetic process 9/1165 57/18722 0.00818720143385223 0.052645979602315 ALDOA/TMSB4X/PARP1/VCP/TGFB1/STOML2/TREM2/ENO1/SLC25A13 9 GO:0006949 syncytium formation 9/1165 57/18722 0.00818720143385223 0.052645979602315 ERVW-1/TYROBP/ERVH48-1/CD9/GDF15/TREM2/PLEKHO1/CD53/CXCL10 9 GO:0033619 membrane protein proteolysis 9/1165 57/18722 0.00818720143385223 0.052645979602315 DAG1/TIMP3/TIMP1/APOE/CTSH/AFG3L2/TGFB1/ADAM8/TNFRSF1B 9 GO:0009595 detection of biotic stimulus 7/1165 38/18722 0.00818812403221468 0.052645979602315 HLA-B/HLA-A/YAP1/HLA-DRB1/TREM2/TLR2/TSPO 7 GO:1901031 regulation of response to reactive oxygen species 7/1165 38/18722 0.00818812403221468 0.052645979602315 MET/BMP7/PAWR/SESN1/STK26/PARK7/GCH1 7 GO:0010821 regulation of mitochondrion organization 17/1165 144/18722 0.00820224664763416 0.0526764421432157 TFRC/BNIP3L/PISD/PMAIP1/GPX1/SLC25A5/PLAUR/TNFSF10/PYCARD/NMT1/TREM2/PARK7/BAD/FIS1/TSPO/BNIP3/VDAC1 17 GO:0003014 renal system process 14/1165 110/18722 0.00827610273559572 0.0529021266724756 GJA5/CLDN4/GJA1/ATP6V1B1/CYBA/COMT/AKR1B1/MAGED2/LGMN/RHOA/PRKACB/GNAI2/CLN3/SULF2 14 GO:0002444 myeloid leukocyte mediated immunity 13/1165 99/18722 0.00830336247968128 0.0529021266724756 TYROBP/HLA-E/ANXA3/STXBP2/S100A13/DHX36/SPI1/TREM1/DDX1/FGR/SYK/CD300A/LYN 13 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 13/1165 99/18722 0.00830336247968128 0.0529021266724756 CD44/PHLDA3/PRKDC/SKIL/CRIP1/CD74/PYCARD/BCL2A1/USP47/BAD/IFI16/RPS3/TNFRSF1B 13 GO:0030838 positive regulation of actin filament polymerization 13/1165 99/18722 0.00830336247968128 0.0529021266724756 SCIN/DLG1/RHOA/ARPC3/GMFG/GRB2/ARPC5L/PYCARD/WASF2/HCK/VASP/WASL/IQGAP2 13 GO:0032602 chemokine production 13/1165 99/18722 0.00830336247968128 0.0529021266724756 APP/AIF1/GSTP1/TREM1/KLF4/CD74/PYCARD/TREM2/LILRB4/OAS1/TLR2/SYK/LRP1 13 GO:0033209 tumor necrosis factor-mediated signaling pathway 13/1165 99/18722 0.00830336247968128 0.0529021266724756 KRT18/KRT8/TMSB4X/LAPTM5/NFKBIA/STAT1/GSTP1/PYCARD/TNFSF13B/LIMS1/SYK/JAK2/TNFRSF1B 13 GO:0042100 B cell proliferation 13/1165 99/18722 0.00830336247968128 0.0529021266724756 TYROBP/HSPD1/SLC39A10/TFRC/PAWR/PTPRC/VAV3/CD74/TNFSF13B/MNDA/GAPT/CD300A/LYN 13 GO:0060485 mesenchyme development 29/1165 291/18722 0.00838647606103357 0.0533710772455571 SEMA6A/LAMA5/SEMA6D/TGFBR3/BMP7/DAG1/ISL1/DLG5/NRP2/FOLR1/GATA3/S100A4/FERMT2/TBX3/DPPA4/EFNA1/YAP1/NRP1/PDCD4/STAT1/HNRNPAB/DAB2/FLNA/TGFB1/MDM2/BASP1/HDAC2/ZFP36L1/PDCD6 29 GO:0071383 cellular response to steroid hormone stimulus 22/1165 204/18722 0.00845195231756011 0.0537268497830859 EGFR/BMP7/ISL1/SERPINF1/PARP1/ASS1/ESRRG/YAP1/ZFP36/ATP2B1/SKP2/DAB2/RHOA/GSTP1/ESRRA/PARK7/CALR/PHB/UFL1/PGRMC2/ZFP36L1/JAK2 22 GO:0099173 postsynapse organization 19/1165 168/18722 0.00848782861961679 0.0538013579548884 SRGN/NRP2/IGF1R/EFNA1/NRP1/APOE/PTN/DLG1/LGMN/DHX36/WASF2/TREM2/LILRB2/ARF4/WASL/DOCK10/ACTB/ABI3/HSPA8 19 GO:0090287 regulation of cellular response to growth factor stimulus 30/1165 304/18722 0.00848970984836813 0.0538013579548884 FBN1/LRP2/FBN2/SEMA6A/CRIM1/TGFBR3/FERMT1/PEG10/CDKN1C/LTBP1/FOLR1/GATA3/FSTL1/HSP90AB1/GPC3/GPC1/NREP/HSPA5/DAB2/HTRA1/LATS2/SKIL/EID2/ATP2B4/TGFB1/SNX6/SULF2/PDCD6/ZEB2/SORL1 30 GO:0044843 cell cycle G1/S phase transition 25/1165 241/18722 0.00849242885231269 0.0538013579548884 EGFR/ADAMTS1/CTDSPL/CDK6/WEE1/NASP/AIF1/BRD4/CCND3/ITGB1/PSME2/DLG1/SKP2/PRKDC/CCNE1/SOX4/LATS2/CCND1/KLF4/ATP2B4/BRD7/PTPN6/MDM2/PSME1/APEX1 25 GO:0010595 positive regulation of endothelial cell migration 16/1165 133/18722 0.00851049775766735 0.0538550438712365 MET/NRP2/GATA3/TMSB4X/ANXA3/PLPP3/NRP1/LGMN/VEGFA/PIK3C2A/CIB1/TGFB1/CALR/RRAS/PDCD6/GRN 16 GO:0033157 regulation of intracellular protein transport 24/1165 229/18722 0.00866464742425273 0.0546925813307413 CDH1/TCAF1/FERMT1/PTPN14/ANK3/LMAN1/GLI3/HSP90AB1/BNIP3L/LCP1/OAZ1/FLNA/RAN/CIB1/TGFB1/MDM2/NMT1/PARK7/HRAS/PCM1/YWHAE/FIS1/SORL1/JAK2 24 GO:0045444 fat cell differentiation 24/1165 229/18722 0.00866464742425273 0.0546925813307413 BMP7/LRP5/ADIRF/ADRB1/GATA3/ARID5B/FERMT2/YAP1/KLF5/PSMB8/ZFP36/CEBPB/GPX1/ATF5/CCND1/KLF4/PLAC8/TGFB1/ARL4A/RETN/ERO1A/BNIP3/ZFP36L1/NR4A1 24 GO:0030500 regulation of bone mineralization 11/1165 78/18722 0.00867208219924456 0.0546925813307413 FBN2/SRGN/BMP7/ISG15/TFAP2A/NOTUM/PTN/ATP2B1/TGFB1/SLC8A1/ATRAID 11 GO:0002688 regulation of leukocyte chemotaxis 15/1165 122/18722 0.00876576609839295 0.0552213749834788 DPP4/JAM3/AIF1/DUSP1/PTN/LGMN/VEGFA/C1QBP/SPI1/CD74/GPSM3/CALR/CXCL10/CCL4/LYN 15 GO:1903320 regulation of protein modification by small protein conjugation or removal 25/1165 242/18722 0.00892953596695039 0.05557868900728 ISG15/LAPTM5/EPAS1/HSP90AB1/NDFIP2/RPL23/NPM1/HSP90AA1/SKP2/HSPA5/VCP/BAG2/SIAH2/UBB/SOX4/GNL3/RPL5/RPL37/PARK7/RPS7/PPIA/UFL1/TSPO/RPS3/PDCD6 25 GO:0060348 bone development 22/1165 205/18722 0.00892972692220504 0.05557868900728 FBN1/HSD17B1/LRP5/SERPINH1/GJA1/TYROBP/TFAP2A/GLI3/NOTUM/MSX2/SNX10/GNAS/DLX5/PPIB/RHOA/TGM2/PTPRC/BBX/WASF2/PTPN6/LILRB1/SULF2 22 GO:1990845 adaptive thermogenesis 18/1165 157/18722 0.00893576131582866 0.05557868900728 LGR4/ADRB1/GJA1/CXCR4/EPAS1/ESRRG/IGF1R/PRLR/GNAS/ID1/CEBPB/VEGFA/SLC25A5/PLAC8/GADD45G/SYK/SORL1/JAK2 18 GO:0033628 regulation of cell adhesion mediated by integrin 8/1165 48/18722 0.0089548207270402 0.05557868900728 DPP4/FERMT1/JAM3/EFNA1/CIB1/PTPN6/SYK/LYN 8 GO:1905710 positive regulation of membrane permeability 8/1165 48/18722 0.0089548207270402 0.05557868900728 JAM3/LAPTM5/SLC9A1/BNIP3L/HEBP2/SLC25A5/NMT1/BNIP3 8 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21/1165 193/18722 0.00900960242337604 0.05557868900728 ISL1/CD44/ERBB3/CD24/EFNA1/NRP1/NCF1/YES1/PECAM1/VEGFA/PTPRC/IL6ST/CD74/TGFB1/TREM2/HDAC2/IGF2/PARP9/SYK/JAK2/LYN 21 GO:0030336 negative regulation of cell migration 33/1165 344/18722 0.00902145782165302 0.05557868900728 CDH1/SEMA6D/ADGRG1/KANK1/NR2F2/TCAF1/DPP4/DAG1/GJA1/DLG5/TACSTD2/SERPINF1/TIMP1/MARVELD3/AIF1/DUSP1/APOE/PTN/RHOA/GSTP1/KLF4/ATP2B4/CD74/STK26/TGFB1/ARHGDIB/CALR/RRAS/WASL/BST2/APEX1/LRP1/CD300A 33 GO:0021543 pallium development 19/1165 169/18722 0.00902290695640134 0.05557868900728 ADGRG1/LAMB1/TACC2/SLC2A1/GNG12/CDK6/GLI3/ASPM/UQCRQ/ANXA3/RHOA/FLNA/ATP2B4/ATIC/BCL2A1/BAD/NME1/BNIP3/LRP1 19 GO:0009159 deoxyribonucleoside monophosphate catabolic process 4/1165 14/18722 0.00902484878799546 0.05557868900728 TYMP/UPP1/DNPH1/PNP 4 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 4/1165 14/18722 0.00902484878799546 0.05557868900728 KANK1/FBLN1/TACSTD2/GBP1 4 GO:0043922 negative regulation by host of viral transcription 4/1165 14/18722 0.00902484878799546 0.05557868900728 PSMC3/NUCKS1/CCL4/JUN 4 GO:0048875 chemical homeostasis within a tissue 4/1165 14/18722 0.00902484878799546 0.05557868900728 EPAS1/CTSH/VEGFA/OAS1 4 GO:0051764 actin crosslink formation 4/1165 14/18722 0.00902484878799546 0.05557868900728 AIF1/LCP1/FLNA/EPS8 4 GO:0060576 intestinal epithelial cell development 4/1165 14/18722 0.00902484878799546 0.05557868900728 YAP1/KLF5/IL6ST/TYMS 4 GO:0072160 nephron tubule epithelial cell differentiation 4/1165 14/18722 0.00902484878799546 0.05557868900728 GATA3/CD24/YAP1/STAT1 4 GO:0072531 pyrimidine-containing compound transmembrane transport 4/1165 14/18722 0.00902484878799546 0.05557868900728 SLC19A3/SLC25A36/SLC29A1/AQP9 4 GO:0090715 immunological memory formation process 4/1165 14/18722 0.00902484878799546 0.05557868900728 HLA-DRA/FGL2/HLA-DRB1/CD46 4 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/1165 14/18722 0.00902484878799546 0.05557868900728 KANK1/FBLN1/TACSTD2/GBP1 4 GO:1905049 negative regulation of metallopeptidase activity 4/1165 14/18722 0.00902484878799546 0.05557868900728 TIMP3/TIMP1/LRP1/SORL1 4 GO:2001171 positive regulation of ATP biosynthetic process 4/1165 14/18722 0.00902484878799546 0.05557868900728 TMSB4X/VCP/TREM2/ENO1 4 GO:0042267 natural killer cell mediated cytotoxicity 10/1165 68/18722 0.00903042301347574 0.05557868900728 HLA-B/HLA-A/CADM1/HLA-E/TUBB4B/PRDX1/HLA-F/TUBB/PTPN6/LILRB1 10 GO:0002763 positive regulation of myeloid leukocyte differentiation 9/1165 58/18722 0.00917008258125275 0.0562531951131931 TYROBP/FOS/HLA-DRB1/EVI2B/CD74/TGFB1/TREM2/ZFP36L1/JUN 9 GO:0006826 iron ion transport 9/1165 58/18722 0.00917008258125275 0.0562531951131931 FTH1/B2M/SLC40A1/TFRC/SLC25A37/CLTC/SLC11A1/PGRMC2/ISCU 9 GO:0018208 peptidyl-proline modification 9/1165 58/18722 0.00917008258125275 0.0562531951131931 PRDX4/PPIC/P4HB/PPIB/FKBP3/ERO1A/PPIA/P4HA1/FKBP2 9 GO:0045070 positive regulation of viral genome replication 6/1165 30/18722 0.00937361209198265 0.0574389570658282 HACD3/DDB1/PABPC1/PPIA/IFIT1/TOP2A 6 GO:0032728 positive regulation of interferon-beta production 7/1165 39/18722 0.00945592584937011 0.0578801655316406 ISG15/HSP90AA1/IRF1/IRF7/OAS1/OAS2/TLR2 7 GO:0002526 acute inflammatory response 14/1165 112/18722 0.00965494111084629 0.0589697328130362 SERPINA1/GATA3/PTGES/ASS1/HLA-E/CEBPB/S100A8/GSTP1/EIF2AK1/PLSCR1/TREM1/IL6ST/PARK7/ADAM8 14 GO:0046632 alpha-beta T cell differentiation 14/1165 112/18722 0.00965494111084629 0.0589697328130362 CTSL/GATA3/PRKCZ/GLI3/HLA-DRA/HLA-DRB1/RHOA/CD86/IRF1/LILRB4/RSAD2/SYK/PNP/CD83 14 GO:0042326 negative regulation of phosphorylation 36/1165 385/18722 0.00971655878432861 0.0592348370495662 NR2F2/FBLN1/BMP7/LRP5/CTDSPL/CDKN1C/PKIB/PRKCZ/MLLT1/PLPP3/DUSP1/NPM1/APOE/PDCD4/FBP1/PRKDC/PTPRC/LATS2/GSTP1/CIB1/PYCARD/PTPN6/TGFB1/VPS25/PRDX3/PARK7/LILRB4/PPIA/SNX6/SLC8A1/SOCS3/LRP1/SORL1/CD300A/CCNB1/LYN 36 GO:0009895 negative regulation of catabolic process 31/1165 320/18722 0.00974505643959007 0.0592348370495662 EGFR/MET/TIMP3/TIMP1/HSP90AB1/EFNA1/RPL23/FBP1/SLIRP/ZFP36/FLNA/DHX36/CST3/APOC1/ATP2B4/FUS/SLC11A1/LRPPRC/RPL5/TREM2/USP14/PARK7/PABPC1/RPS7/YBX1/PHB/TSPO/SNX3/CIRBP/SORL1/ATRAID 31 GO:0034644 cellular response to UV 12/1165 90/18722 0.00975111160409748 0.0592348370495662 MME/TIMP1/PARP1/DDB1/NPM1/PTN/DHX36/EIF2AK4/CRIP1/MDM2/OPN3/USP47 12 GO:0046849 bone remodeling 12/1165 90/18722 0.00975111160409748 0.0592348370495662 EGFR/LGR4/LRP5/GJA1/SYT7/TFRC/SNX10/PTN/TGFB1/SUCO/SYK/ADAM8 12 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 12/1165 90/18722 0.00975111160409748 0.0592348370495662 ADAMTS1/GJA1/SOD2/PDCD4/DNMT1/RHOA/HPGD/GSTP1/MDM2/GNAI2/JUN/JAK2 12 GO:0006576 cellular biogenic amine metabolic process 13/1165 101/18722 0.00977681695092036 0.0592627144120043 ALDH7A1/GATA3/EPAS1/SMS/COMT/AKR1B1/OAZ1/SRM/IL4I1/PNKD/PARK7/KYNU/GCH1 13 GO:0048024 regulation of mRNA splicing, via spliceosome 13/1165 101/18722 0.00977681695092036 0.0592627144120043 MBNL3/MBNL2/NPM1/C1QBP/RBM39/PRDX6/SF1/NCL/SRSF2/RBM3/HSPA8/CIRBP/SON 13 GO:0050679 positive regulation of epithelial cell proliferation 22/1165 207/18722 0.00995098147330237 0.0602326740701698 EGFR/LAMB1/LAMC1/NRP2/CYBA/YAP1/NRP1/PTN/ID1/DLX5/HTRA1/VEGFA/CCND1/MYDGF/HRAS/IGF2/BAD/GLUL/NME1/PDCD6/GRN/NR4A1 22 GO:0045669 positive regulation of osteoblast differentiation 10/1165 69/18722 0.00998869523130769 0.0602326740701698 FBN2/BMP7/LRP5/GLI3/FERMT2/YAP1/CEBPB/IL6ST/SUCO/ATRAID 10 GO:0050688 regulation of defense response to virus 10/1165 69/18722 0.00998869523130769 0.0602326740701698 FGL2/HSP90AA1/STAT1/HTRA1/C1QBP/EIF2AK4/PYCARD/IFIT1/LILRB1/PARP9 10 GO:0060193 positive regulation of lipase activity 10/1165 69/18722 0.00998869523130769 0.0602326740701698 EGFR/PRKCZ/FLT1/RHOA/CD86/HRAS/ARF4/PHB/ARL1/S1PR4 10 GO:0002220 innate immune response activating cell surface receptor signaling pathway 5/1165 22/18722 0.010011951702738 0.0602326740701698 TYROBP/FCN1/SYK/LILRA2/LYN 5 GO:0032069 regulation of nuclease activity 5/1165 22/18722 0.010011951702738 0.0602326740701698 NPM1/OAS1/OAS2/OASL/RPS3 5 GO:0048026 positive regulation of mRNA splicing, via spliceosome 5/1165 22/18722 0.010011951702738 0.0602326740701698 PRDX6/NCL/RBM3/HSPA8/CIRBP 5 GO:0030705 cytoskeleton-dependent intracellular transport 21/1165 195/18722 0.010074810650201 0.0604165728414298 SYNE2/APP/PRKCZ/SOD1/MYO7A/FNBP1L/TUBB/UBB/ARMCX3/TUBA1B/HSPB11/LRPPRC/DST/CCDC186/MYO1G/TUBA1C/WASL/PCM1/CLN3/HSPA8/MYO1F 21 GO:0070302 regulation of stress-activated protein kinase signaling cascade 21/1165 195/18722 0.010074810650201 0.0604165728414298 EGFR/PAGE4/APP/MARVELD3/IGF1R/NCF1/DUSP1/PDCD4/PRDX1/DLG1/VEGFA/GSTP1/SPI1/PYCARD/ARL6IP5/GADD45G/TREM2/HRAS/PPIA/PRMT1/LYN 21 GO:1901605 alpha-amino acid metabolic process 21/1165 195/18722 0.010074810650201 0.0604165728414298 GLDC/GCSH/ASS1/SMS/COMT/GCLM/CDO1/ADI1/GFPT1/RIMKLB/IL4I1/ASNSD1/MTR/ATP2B4/PARK7/SLC25A13/KYNU/AASDHPPT/GLUL/CLN3/SLC7A7 21 GO:0002762 negative regulation of myeloid leukocyte differentiation 8/1165 49/18722 0.010133520168981 0.0605100518175432 FBN1/CDK6/C1QC/LILRB4/LILRB1/NME1/LILRB3/LYN 8 GO:0034332 adherens junction organization 8/1165 49/18722 0.010133520168981 0.0605100518175432 CDH1/DSP/JAM3/DLG5/TJP1/FERMT2/VEGFA/ACTB 8 GO:0070849 response to epidermal growth factor 8/1165 49/18722 0.010133520168981 0.0605100518175432 EGFR/ZFP36/ID1/GSTP1/MCM7/SNX6/NCL/ZFP36L1 8 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 8/1165 49/18722 0.010133520168981 0.0605100518175432 ADAMTS1/GJA1/DNMT1/HPGD/MDM2/GNAI2/JUN/JAK2 8 GO:0043407 negative regulation of MAP kinase activity 9/1165 59/18722 0.0102396072506311 0.0610785499445192 BMP7/DUSP1/APOE/PDCD4/GSTP1/PTPN6/SORL1/CD300A/LYN 9 GO:0003158 endothelium development 16/1165 136/18722 0.0104548198515155 0.0622960762489986 MET/NR2F2/GJA5/GJA1/CXCR4/FSTL1/TJP1/NRP1/PTN/ID1/GPX1/PECAM1/RHOA/VEGFA/MSN/CXCL10 16 GO:0048193 Golgi vesicle transport 29/1165 296/18722 0.0104864593121266 0.0624183415895724 KRT18/ANK3/LMAN1/LAPTM5/PLPP3/VAMP5/ERGIC2/GOLGA4/VCP/TMED4/TMED1/TFG/ERGIC3/TMED9/TMED3/TRAPPC6A/TRAPPC2L/ARF4/ARL1/KDELR1/RABEP1/YIF1A/CLN3/CREB3L2/TAPBP/KDELR2/SNX3/PDCD6/SORL1 29 GO:1902749 regulation of cell cycle G2/M phase transition 13/1165 102/18722 0.0105862351156767 0.0628532810379698 PBX1/APP/BRD4/NPM1/FOXO4/ATF5/CCND1/CENPF/USP47/RAD21/BABAM1/RAB11A/CCNB1 13 GO:0001657 ureteric bud development 12/1165 91/18722 0.0106154976021199 0.0628532810379698 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA/BASP1 12 GO:0060191 regulation of lipase activity 12/1165 91/18722 0.0106154976021199 0.0628532810379698 EGFR/PRKCZ/FLT1/RHOA/CD86/APOC1/HRAS/ARF4/PHB/ARL1/S1PR4/LRP1 12 GO:1990874 vascular associated smooth muscle cell proliferation 12/1165 91/18722 0.0106154976021199 0.0628532810379698 ADAMTS1/GJA1/SOD2/PDCD4/DNMT1/RHOA/HPGD/GSTP1/MDM2/GNAI2/JUN/JAK2 12 GO:1901342 regulation of vasculature development 33/1165 348/18722 0.0106155194056646 0.0628532810379698 SEMA6A/COL4A2/ADAMTS1/ISL1/CXCR4/SERPINF1/AMOT/TJP1/CYBB/FLT1/ANXA3/EFNA1/KLF2/NRP1/ITGB8/CTSH/ITGB1/PTN/STAT1/ID1/FOXO4/VEGFA/KLF4/ATP2B4/PGK1/PKM/MYDGF/JAK1/RRAS/CXCL10/GLUL/PDCD6/GRN 33 GO:0031032 actomyosin structure organization 21/1165 196/18722 0.0106441841765926 0.0629565919738823 MYH10/MET/FRMD6/KRT8/TACSTD2/SORBS1/TJP1/ITGB5/OBSL1/CSRP2/FERMT2/PDLIM1/S100A10/NRP1/SLC9A1/CNN3/ITGB1/RHOA/WASF2/KRT19/STMN1 21 GO:0090316 positive regulation of intracellular protein transport 18/1165 160/18722 0.010769521144582 0.0636308654574092 CDH1/TCAF1/ANK3/GLI3/HSP90AB1/OAZ1/FLNA/RAN/CIB1/TGFB1/MDM2/NMT1/HRAS/PCM1/YWHAE/FIS1/SORL1/JAK2 18 GO:0009394 2'-deoxyribonucleotide metabolic process 7/1165 40/18722 0.0108613695390318 0.0639715290898062 TYMP/UPP1/ADK/TYMS/DNPH1/PNP/DUT 7 GO:0010543 regulation of platelet activation 7/1165 40/18722 0.0108613695390318 0.0639715290898062 FCER1G/APOE/CD9/IL6ST/SYK/JAK2/LYN 7 GO:0045429 positive regulation of nitric oxide biosynthetic process 7/1165 40/18722 0.0108613695390318 0.0639715290898062 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/JAK2 7 GO:0002548 monocyte chemotaxis 10/1165 70/18722 0.0110224712650699 0.0645973843745194 FLT1/AIF1/DUSP1/LGMN/CCL3L3/LGALS3/S100A12/CXCL10/CCL4/LYN 10 GO:0002230 positive regulation of defense response to virus by host 6/1165 31/18722 0.0110251726760715 0.0645973843745194 HSP90AA1/STAT1/EIF2AK4/PYCARD/LILRB1/PARP9 6 GO:0033238 regulation of cellular amine metabolic process 6/1165 31/18722 0.0110251726760715 0.0645973843745194 COMT/PNKD/ATP2B4/PARK7/CLN3/SLC7A7 6 GO:0060390 regulation of SMAD protein signal transduction 6/1165 31/18722 0.0110251726760715 0.0645973843745194 PARP1/RBPMS/DAB2/TGFB1/LRP1/JAK2 6 GO:0071711 basement membrane organization 6/1165 31/18722 0.0110251726760715 0.0645973843745194 LAMB1/DAG1/FERMT1/SPINT2/CTSS/ITGB1 6 GO:0006986 response to unfolded protein 16/1165 137/18722 0.0111756500170528 0.0652746342827442 SERPINH1/HSPD1/HSP90AB1/HSPE1/HSP90AA1/HSPA5/VCP/DNAJB4/CCND1/SERP1/ERO1A/UFL1/CREB3L2/HSPA8/MANF/UBXN4 16 GO:0010977 negative regulation of neuron projection development 16/1165 137/18722 0.0111756500170528 0.0652746342827442 SEMA6A/SEMA6D/KANK1/B2M/EFNA1/NRP1/ITM2C/APOE/RHOA/FLNA/VIM/MYLIP/CIB1/MDM2/HDAC2/LRP1 16 GO:0050684 regulation of mRNA processing 16/1165 137/18722 0.0111756500170528 0.0652746342827442 MBNL3/MBNL2/NPM1/C1QBP/DHX36/RBM39/PRDX6/SF1/NCL/SRSF2/ZFP36L1/RBM3/HSPA8/CIRBP/CCNB1/SON 16 GO:0021987 cerebral cortex development 14/1165 114/18722 0.0112080955570387 0.0653960918520358 ADGRG1/LAMB1/TACC2/SLC2A1/GNG12/GLI3/ASPM/RHOA/FLNA/ATIC/BCL2A1/BAD/BNIP3/LRP1 14 GO:1905039 carboxylic acid transmembrane transport 17/1165 149/18722 0.0113609680955269 0.066219225254613 LRP2/SLC2A1/SLC38A1/FOLR1/SLC38A9/SLC19A1/SLC13A3/ITGB1/MPC2/SLC5A6/ARL6IP5/SLC1A3/SLC16A3/SLC25A13/SLC25A1/AQP9/SLC7A7 17 GO:0046209 nitric oxide metabolic process 11/1165 81/18722 0.011422242783907 0.0663696156791615 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/ATP2B4/TLR2/GCH1/TSPO/JAK2 11 GO:0051817 modulation of process of other organism involved in symbiotic interaction 11/1165 81/18722 0.011422242783907 0.0663696156791615 DAG1/APOE/PPIB/PSMC3/TAF11/EIF2AK4/NUCKS1/PHB/CCL4/HSPA8/JUN 11 GO:0071260 cellular response to mechanical stimulus 11/1165 81/18722 0.011422242783907 0.0663696156791615 EGFR/DAG1/SLC2A1/GJA1/TMEM150C/CYBA/SLC9A1/IRF1/BAD/BNIP3/MAP3K2 11 GO:0003279 cardiac septum development 13/1165 103/18722 0.0114468207960683 0.066443645427437 LRP2/ADAMTS6/TGFBR3/GJA5/BMP7/ISL1/NRP2/LMO4/GATA3/TBX3/NRP1/SOX4/MDM2 13 GO:0072163 mesonephric epithelium development 12/1165 92/18722 0.0115378878395485 0.0668340190334219 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA/BASP1 12 GO:0072164 mesonephric tubule development 12/1165 92/18722 0.0115378878395485 0.0668340190334219 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA/BASP1 12 GO:0007623 circadian rhythm 22/1165 210/18722 0.0116576328390251 0.0672047467600079 EGFR/MAGED1/CLDN4/LGR4/SLC6A4/ADRB1/NR2F6/ASS1/DDB1/ID1/GNA11/SIAH2/GFPT1/PRKDC/ATF5/OPN3/BHLHE41/HDAC2/TYMS/IMPDH2/JUN/TOP2A 22 GO:0031396 regulation of protein ubiquitination 22/1165 210/18722 0.0116576328390251 0.0672047467600079 ISG15/LAPTM5/HSP90AB1/NDFIP2/RPL23/NPM1/HSP90AA1/SKP2/HSPA5/BAG2/SIAH2/UBB/SOX4/RPL5/RPL37/PARK7/RPS7/PPIA/UFL1/TSPO/RPS3/PDCD6 22 GO:0006089 lactate metabolic process 4/1165 15/18722 0.01170964588122 0.0672047467600079 LDHA/MRS2/PNKD/PARK7 4 GO:0019511 peptidyl-proline hydroxylation 4/1165 15/18722 0.01170964588122 0.0672047467600079 PRDX4/P4HB/ERO1A/P4HA1 4 GO:0023035 CD40 signaling pathway 4/1165 15/18722 0.01170964588122 0.0672047467600079 ITGB1/CD86/TREM2/PHB 4 GO:0045176 apical protein localization 4/1165 15/18722 0.01170964588122 0.0672047467600079 JAM3/DLG5/ARF4/ACTB 4 GO:0086069 bundle of His cell to Purkinje myocyte communication 4/1165 15/18722 0.01170964588122 0.0672047467600079 GJA5/DSP/DSG2/DSC2 4 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/1165 15/18722 0.01170964588122 0.0672047467600079 ZFP36/DHX36/PABPC1/ZFP36L1 4 GO:2001028 positive regulation of endothelial cell chemotaxis 4/1165 15/18722 0.01170964588122 0.0672047467600079 MET/TMSB4X/LGMN/VEGFA 4 GO:0031345 negative regulation of cell projection organization 20/1165 186/18722 0.0120178709574522 0.0689032785333804 SEMA6A/SEMA6D/KANK1/B2M/TACSTD2/EFNA1/YAP1/NRP1/ITM2C/APOE/ID1/RHOA/FLNA/VIM/MYLIP/CIB1/MDM2/HDAC2/ABI3/LRP1 20 GO:1901989 positive regulation of cell cycle phase transition 14/1165 115/18722 0.01205440279508 0.0689615881983757 EGFR/PBX1/ADAMTS1/APP/AIF1/BRD4/CCND3/NPM1/CCND1/ANAPC11/MDM2/APEX1/RAB11A/CCNB1 14 GO:1903825 organic acid transmembrane transport 17/1165 150/18722 0.0120949488086147 0.0689615881983757 LRP2/SLC2A1/SLC38A1/FOLR1/SLC38A9/SLC19A1/SLC13A3/ITGB1/MPC2/SLC5A6/ARL6IP5/SLC1A3/SLC16A3/SLC25A13/SLC25A1/AQP9/SLC7A7 17 GO:0001659 temperature homeostasis 19/1165 174/18722 0.0121188769174811 0.0689615881983757 LGR4/ADRB1/GJA1/CXCR4/PTGES/EPAS1/ESRRG/IGF1R/PRLR/GNAS/ID1/CEBPB/GPX1/VEGFA/PLAC8/GADD45G/SYK/ACADVL/JAK2 19 GO:0002228 natural killer cell mediated immunity 10/1165 71/18722 0.0121353115778844 0.0689615881983757 HLA-B/HLA-A/CADM1/HLA-E/TUBB4B/PRDX1/HLA-F/TUBB/PTPN6/LILRB1 10 GO:0045824 negative regulation of innate immune response 10/1165 71/18722 0.0121353115778844 0.0689615881983757 HLA-B/HLA-A/ISG15/HLA-E/HLA-F/A2M/OAS1/LILRB1/IFI16/GRN 10 GO:0061515 myeloid cell development 10/1165 71/18722 0.0121353115778844 0.0689615881983757 FBN1/TYROBP/APP/KLF2/EVI2B/FAM210B/WASF2/PTPN6/TLR2/LILRB1 10 GO:0071230 cellular response to amino acid stimulus 10/1165 71/18722 0.0121353115778844 0.0689615881983757 SLC38A9/CYBA/ASS1/CYBB/GCLM/SESN1/DNMT1/CEBPB/DNMT3A/LAMTOR5 10 GO:0051131 chaperone-mediated protein complex assembly 5/1165 23/18722 0.0121509016084435 0.0689615881983757 HSPD1/HSP90AB1/HSP90AA1/CCT2/PSMG1 5 GO:1904666 regulation of ubiquitin protein ligase activity 5/1165 23/18722 0.0121509016084435 0.0689615881983757 RPL23/BAG2/RPL5/RPL37/RPS7 5 GO:2001169 regulation of ATP biosynthetic process 5/1165 23/18722 0.0121509016084435 0.0689615881983757 TMSB4X/PARP1/VCP/TREM2/ENO1 5 GO:0048762 mesenchymal cell differentiation 24/1165 236/18722 0.012296932491851 0.0697198808856159 SEMA6A/LAMA5/SEMA6D/TGFBR3/BMP7/DAG1/ISL1/DLG5/NRP2/FOLR1/GATA3/S100A4/FERMT2/TBX3/EFNA1/NRP1/PDCD4/STAT1/HNRNPAB/DAB2/FLNA/TGFB1/HDAC2/PDCD6 24 GO:0009167 purine ribonucleoside monophosphate metabolic process 7/1165 41/18722 0.0124123431227664 0.0701616132407731 DLG1/PAICS/ATIC/AK3/ADK/IMPDH2/PNP 7 GO:0042307 positive regulation of protein import into nucleus 7/1165 41/18722 0.0124123431227664 0.0701616132407731 CDH1/GLI3/HSP90AB1/FLNA/RAN/TGFB1/JAK2 7 GO:1904407 positive regulation of nitric oxide metabolic process 7/1165 41/18722 0.0124123431227664 0.0701616132407731 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/JAK2 7 GO:0060395 SMAD protein signal transduction 11/1165 82/18722 0.0124729746779026 0.0703212590710092 BMP7/PARP1/RBPMS/DAB2/FOS/VIM/TGFB1/GDF15/JUN/LRP1/JAK2 11 GO:2001057 reactive nitrogen species metabolic process 11/1165 82/18722 0.0124729746779026 0.0703212590710092 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/ATP2B4/TLR2/GCH1/TSPO/JAK2 11 GO:0006790 sulfur compound metabolic process 32/1165 339/18722 0.0124781710377205 0.0703212590710092 ACSS1/SLC26A2/CHPF/SLC19A3/CLIC3/SOD1/SMS/TSTD1/TPST2/COMT/MPC2/GSTA4/GCLM/IDH1/CDO1/GPX1/ADI1/GSTP1/MTR/TECR/ARL6IP5/DLD/GPX4/ST3GAL4/GSTO1/PMVK/PARK7/GLRX5/KYNU/SLC25A1/ISCU/GAL3ST4 32 GO:0032755 positive regulation of interleukin-6 production 12/1165 93/18722 0.0125207022995114 0.070419541089336 ISL1/TYROBP/APP/HSPD1/CYBA/AIF1/CD74/PYCARD/LILRB2/TLR2/SYK/LILRA2 12 GO:0097306 cellular response to alcohol 12/1165 93/18722 0.0125207022995114 0.070419541089336 CDH1/DAG1/SOD2/CYBB/KLF2/GNAI1/ATP2B1/DNMT3A/SPI1/KLF4/MDM2/FDX1 12 GO:0030865 cortical cytoskeleton organization 9/1165 61/18722 0.0126565217296733 0.0709700863822738 RHOBTB3/LCP1/DLG1/RND3/RHOA/RHOBTB1/CALR/RHOG/FMNL1 9 GO:0040014 regulation of multicellular organism growth 9/1165 61/18722 0.0126565217296733 0.0709700863822738 ADRB1/APP/SOD1/LGMN/PPIB/AFG3L2/PLAC8/GDF15/IGF2 9 GO:2000401 regulation of lymphocyte migration 9/1165 61/18722 0.0126565217296733 0.0709700863822738 APP/AIF1/RHOA/PYCARD/MSN/WASL/CXCL10/CCL4/ADAM8 9 GO:0031330 negative regulation of cellular catabolic process 26/1165 262/18722 0.0127106959555549 0.0712027309366562 MET/TIMP3/TIMP1/HSP90AB1/EFNA1/RPL23/SLIRP/ZFP36/DHX36/CST3/APOC1/ATP2B4/FUS/SLC11A1/LRPPRC/RPL5/TREM2/USP14/PARK7/PABPC1/RPS7/YBX1/TSPO/CIRBP/SORL1/ATRAID 26 GO:0048771 tissue remodeling 19/1165 175/18722 0.0128288134204609 0.0715364955930037 EGFR/LGR4/LRP5/GJA1/TIMP1/SYT7/TFRC/EPAS1/SNX10/PTN/TGM2/FLNA/CST3/TGFB1/MDM2/SUCO/LIPA/SYK/ADAM8 19 GO:0014009 glial cell proliferation 8/1165 51/18722 0.0128304554983758 0.0715364955930037 EGFR/PTN/SOX4/ETV5/TREM2/UFL1/TSPO/LYN 8 GO:0021872 forebrain generation of neurons 8/1165 51/18722 0.0128304554983758 0.0715364955930037 B2M/NRP2/GLI3/ASPM/UQCRQ/NRP1/RHOA/UBB 8 GO:0007435 salivary gland morphogenesis 6/1165 32/18722 0.0128722359787874 0.0715364955930037 LAMA5/BMP7/DAG1/NRP1/TGM2/TGFB1 6 GO:0010039 response to iron ion 6/1165 32/18722 0.0128722359787874 0.0715364955930037 B2M/TFAP2A/C1QA/CCND1/MDM2/CCNB1 6 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 6/1165 32/18722 0.0128722359787874 0.0715364955930037 TGFBR3/FERMT1/CDKN1C/HSP90AB1/DAB2/ZEB2 6 GO:0035767 endothelial cell chemotaxis 6/1165 32/18722 0.0128722359787874 0.0715364955930037 MET/TMSB4X/NRP1/LGMN/VEGFA/NR4A1 6 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 6/1165 32/18722 0.0128722359787874 0.0715364955930037 TGFBR3/FERMT1/CDKN1C/HSP90AB1/DAB2/ZEB2 6 GO:0071322 cellular response to carbohydrate stimulus 18/1165 163/18722 0.0128906521661348 0.0715679827977396 LRP5/COLEC12/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/SLC29A1/TREM2/CCDC186/BAD/NME1/FIS1/ZFP36L1/LRP1 18 GO:0008286 insulin receptor signaling pathway 14/1165 116/18722 0.0129495492568972 0.0718239327855376 KANK1/SORBS1/PRKCZ/IGF1R/CCND3/FOXO4/GRB2/PIK3C2A/NUCKS1/IGF2/PTPRA/GNAI2/SOCS3/SORL1 14 GO:0000041 transition metal ion transport 13/1165 105/18722 0.0133296984446279 0.073719840373907 FTH1/B2M/SLC40A1/SLC39A10/TFRC/SLC25A37/SLC39A1/CLTC/SLC11A1/SLC39A7/TMEM165/PGRMC2/ISCU 13 GO:0043903 regulation of biological process involved in symbiotic interaction 10/1165 72/18722 0.013330774626673 0.073719840373907 IFITM3/FCN1/DDB1/P4HB/HLA-DRB1/IFITM2/CD74/TRIM22/FUCA2/SNX3 10 GO:0071479 cellular response to ionizing radiation 10/1165 72/18722 0.013330774626673 0.073719840373907 GATA3/CYBA/YAP1/NET1/HSPA5/GRB2/NUCKS1/MDM2/HRAS/IFI16 10 GO:0008380 RNA splicing 39/1165 434/18722 0.0135672383843436 0.0749020819998743 ESRP1/MBNL3/MBNL2/NPM1/SNRPF/C1QBP/SNRPA1/LGALS3/LSM7/SNRPG/SNU13/LSM3/DDX1/FUS/MFAP1/PABPC1/SNRPD1/RBM39/DHX15/PRDX6/RBM17/SF3B6/SNRPE/YBX1/CTNNBL1/SNRPB2/SNRPD2/SF1/SNRPD3/NCL/SRSF2/ZC3H13/RBM3/HSPA8/PRMT1/SRSF11/CIRBP/SNRPC/SON 39 GO:0010634 positive regulation of epithelial cell migration 19/1165 176/18722 0.0135712484222113 0.0749020819998743 MET/NRP2/GATA3/TMSB4X/ANXA3/PLPP3/NRP1/CTSH/LGMN/VEGFA/RAB25/PIK3C2A/CIB1/TGFB1/CALR/RRAS/RAB11A/PDCD6/GRN 19 GO:0050680 negative regulation of epithelial cell proliferation 18/1165 164/18722 0.0136665383581995 0.0753539094347485 NR2F2/TGFBR3/MAGED1/GJA1/ISL1/B2M/CDKN1C/SERPINF1/GATA3/CDK6/GPC3/MARVELD3/FLT1/APOE/PTN/STAT1/DLG1/TGFB1 18 GO:0003015 heart process 25/1165 251/18722 0.0137481899702314 0.0757297255180657 GJA5/DSP/DSG2/ADRB1/GJA1/ISL1/CXCR4/DSC2/SOD1/EPAS1/YAP1/SLC9A1/ATP2B1/DLG1/GPX1/FLNA/ATP2B4/AKAP9/MDM2/GSTO1/GNAI2/YWHAE/GCH1/SLC8A1/JAK2 25 GO:0015833 peptide transport 26/1165 264/18722 0.0139098385117122 0.0765450231041574 EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/SYT7/SLC13A3/MPC2/S100A8/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/CD74/TAP1/PARK7/UQCC2/CCDC186/BAD/GLUL/TAPBP/LRP1/JAK2/ENSA 26 GO:0032615 interleukin-12 production 9/1165 62/18722 0.0140128372486918 0.0766608727845098 HLA-B/ISL1/HSPD1/LAPTM5/C1QBP/IRF1/TLR2/LILRB1/SYK 9 GO:0032655 regulation of interleukin-12 production 9/1165 62/18722 0.0140128372486918 0.0766608727845098 HLA-B/ISL1/HSPD1/LAPTM5/C1QBP/IRF1/TLR2/LILRB1/SYK 9 GO:0032731 positive regulation of interleukin-1 beta production 9/1165 62/18722 0.0140128372486918 0.0766608727845098 ISL1/TYROBP/APP/PYCARD/GBP5/MNDA/IFI16/JAK2/LILRA2 9 GO:0032757 positive regulation of interleukin-8 production 9/1165 62/18722 0.0140128372486918 0.0766608727845098 FCN1/CD14/CD74/PYCARD/PARK7/TLR2/LAMTOR5/SYK/LILRA2 9 GO:0045428 regulation of nitric oxide biosynthetic process 9/1165 62/18722 0.0140128372486918 0.0766608727845098 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/ATP2B4/TSPO/JAK2 9 GO:0046824 positive regulation of nucleocytoplasmic transport 9/1165 62/18722 0.0140128372486918 0.0766608727845098 CDH1/GLI3/HSP90AB1/FLNA/RAN/TGFB1/MDM2/YWHAE/JAK2 9 GO:0045765 regulation of angiogenesis 32/1165 342/18722 0.0140386521051524 0.0767273167149178 SEMA6A/COL4A2/ADAMTS1/ISL1/CXCR4/SERPINF1/AMOT/TJP1/CYBB/FLT1/ANXA3/EFNA1/KLF2/NRP1/ITGB8/CTSH/ITGB1/PTN/STAT1/FOXO4/VEGFA/KLF4/ATP2B4/PGK1/PKM/MYDGF/JAK1/RRAS/CXCL10/GLUL/PDCD6/GRN 32 GO:0009124 nucleoside monophosphate biosynthetic process 7/1165 42/18722 0.0141165744875894 0.0768431584470369 UPP1/PAICS/ATIC/ADK/TYMS/IMPDH2/DUT 7 GO:0019692 deoxyribose phosphate metabolic process 7/1165 42/18722 0.0141165744875894 0.0768431584470369 TYMP/UPP1/ADK/TYMS/DNPH1/PNP/DUT 7 GO:0033574 response to testosterone 7/1165 42/18722 0.0141165744875894 0.0768431584470369 NASP/DUSP1/MSN/CALR/BAD/NME1/TSPO 7 GO:0072595 maintenance of protein localization in organelle 7/1165 42/18722 0.0141165744875894 0.0768431584470369 GJA1/HSPA5/GPAA1/PARK7/KDELR1/TSPO/KDELR2 7 GO:0015849 organic acid transport 29/1165 303/18722 0.0141282985065637 0.0768431584470369 LRP2/SLC27A2/SLC26A2/SLC2A1/SLC38A1/GJA1/FOLR1/SLC38A9/SLC19A1/PTGES/SLC13A3/APOE/ITGB1/MPC2/SLC5A6/PLIN2/SLC11A1/ARL6IP5/SLC1A3/SLCO2B1/SLC16A3/SFXN4/SLC25A13/SLC25A1/FIS1/CLN3/SYK/AQP9/SLC7A7 29 GO:0051403 stress-activated MAPK cascade 24/1165 239/18722 0.0141878542237534 0.0770923773068031 EGFR/PAGE4/HACD3/DUSP9/APP/MARVELD3/IGF1R/NCF1/DUSP1/PDCD4/PRDX1/ZFP36/DLG1/VEGFA/GSTP1/SPI1/PYCARD/ARL6IP5/GADD45G/TREM2/HRAS/PPIA/ZFP36L1/PRMT1 24 GO:0009185 ribonucleoside diphosphate metabolic process 13/1165 106/18722 0.0143561137033822 0.0777807588967995 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/DLG1/AK3/PGK1/PKM/ENO1/BAD/NUDT5 13 GO:0030038 contractile actin filament bundle assembly 13/1165 106/18722 0.0143561137033822 0.0777807588967995 MET/TACSTD2/SORBS1/TJP1/ITGB5/FERMT2/PDLIM1/S100A10/NRP1/SLC9A1/RHOA/WASF2/STMN1 13 GO:0043149 stress fiber assembly 13/1165 106/18722 0.0143561137033822 0.0777807588967995 MET/TACSTD2/SORBS1/TJP1/ITGB5/FERMT2/PDLIM1/S100A10/NRP1/SLC9A1/RHOA/WASF2/STMN1 13 GO:0008584 male gonad development 16/1165 141/18722 0.0144583437938686 0.0782181680174046 LRP2/ADGRG1/CTSV/GATA3/PRDX4/RHOBTB3/ASPM/ARID5B/NASP/TFAP2C/UBB/FLNA/CCND1/TNFSF10/EIF2S2/SF1 16 GO:0032635 interleukin-6 production 18/1165 165/18722 0.0144786525156037 0.0782181680174046 HLA-B/ISL1/TYROBP/APP/HSPD1/CYBA/KLF2/AIF1/CEBPB/CD74/PYCARD/PTPN6/TREM2/LILRB2/LILRB4/TLR2/SYK/LILRA2 18 GO:0032675 regulation of interleukin-6 production 18/1165 165/18722 0.0144786525156037 0.0782181680174046 HLA-B/ISL1/TYROBP/APP/HSPD1/CYBA/KLF2/AIF1/CEBPB/CD74/PYCARD/PTPN6/TREM2/LILRB2/LILRB4/TLR2/SYK/LILRA2 18 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 5/1165 24/18722 0.0145795312709132 0.0784610824771197 HSPD1/IRF1/IRF7/TLR2/CD300A 5 GO:0051043 regulation of membrane protein ectodomain proteolysis 5/1165 24/18722 0.0145795312709132 0.0784610824771197 TIMP3/TIMP1/APOE/ADAM8/TNFRSF1B 5 GO:1901984 negative regulation of protein acetylation 5/1165 24/18722 0.0145795312709132 0.0784610824771197 HINT2/SPI1/PARK7/HDAC2/SET 5 GO:1903077 negative regulation of protein localization to plasma membrane 5/1165 24/18722 0.0145795312709132 0.0784610824771197 GBP1/DAB2/CLTC/TGFB1/ABI3 5 GO:0043299 leukocyte degranulation 10/1165 73/18722 0.0146124062491046 0.0784896287961629 ANXA3/STXBP2/HLA-F/S100A13/SPI1/HCK/FGR/SYK/CD300A/LYN 10 GO:0098657 import into cell 23/1165 227/18722 0.0146128027956512 0.0784896287961629 LRP2/SLC27A2/SLC2A1/SLC6A4/SLC38A1/FOLR1/SLC19A1/SLC39A10/SLC9A1/SLC5A3/ITGB1/DLG1/SLC5A6/ATP2B4/ARL6IP5/SLC1A3/SLC29A1/SLC2A3/TREM2/PARK7/ACTB/ISCU/SLC8A1 23 GO:0002532 production of molecular mediator involved in inflammatory response 12/1165 95/18722 0.0146773169229469 0.0786855586327612 NCF1/PRDX2/PDCD4/PYCARD/GBP5/TREM2/CHID1/GPSM3/LILRB4/SYK/GRN/LYN 12 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 12/1165 95/18722 0.0146773169229469 0.0786855586327612 ISG15/RPL23/BAG2/SOX4/RPL5/RPL37/PARK7/RPS7/PPIA/UFL1/TSPO/RPS3 12 GO:0001732 formation of cytoplasmic translation initiation complex 4/1165 16/18722 0.0148573612950837 0.0788226549615357 EIF3A/EIF2S2/EIF5/EIF3J 4 GO:0009415 response to water 4/1165 16/18722 0.0148573612950837 0.0788226549615357 KRT8/AKR1B1/CD9/ATP2B4 4 GO:0010649 regulation of cell communication by electrical coupling 4/1165 16/18722 0.0148573612950837 0.0788226549615357 GJA5/GJA1/ANK3/SLC8A1 4 GO:0017014 protein nitrosylation 4/1165 16/18722 0.0148573612950837 0.0788226549615357 GAPDH/ADH5/S100A8/ATP2B4 4 GO:0018119 peptidyl-cysteine S-nitrosylation 4/1165 16/18722 0.0148573612950837 0.0788226549615357 GAPDH/ADH5/S100A8/ATP2B4 4 GO:0045342 MHC class II biosynthetic process 4/1165 16/18722 0.0148573612950837 0.0788226549615357 SPI1/SLC11A1/HDAC2/JAK2 4 GO:0051014 actin filament severing 4/1165 16/18722 0.0148573612950837 0.0788226549615357 SCIN/DSTN/GMFG/FMNL1 4 GO:0071361 cellular response to ethanol 4/1165 16/18722 0.0148573612950837 0.0788226549615357 SOD2/CYBB/DNMT3A/SPI1 4 GO:0099633 protein localization to postsynaptic specialization membrane 4/1165 16/18722 0.0148573612950837 0.0788226549615357 DAG1/PRKCZ/DLG1/HRAS 4 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 4/1165 16/18722 0.0148573612950837 0.0788226549615357 DAG1/PRKCZ/DLG1/HRAS 4 GO:1905906 regulation of amyloid fibril formation 4/1165 16/18722 0.0148573612950837 0.0788226549615357 APP/APOE/PFDN5/TREM2 4 GO:0022612 gland morphogenesis 14/1165 118/18722 0.0148934694332404 0.0788864197619626 LAMA5/BMP7/LRP5/DAG1/GLI3/TBX3/NRP1/PTN/CEBPB/TGM2/CRIP1/MSN/TGFB1/SULF2 14 GO:0048048 embryonic eye morphogenesis 6/1165 33/18722 0.0149255973253526 0.0788864197619626 FBN1/FBN2/EFEMP1/BMP7/TFAP2A/MFAP5 6 GO:0071353 cellular response to interleukin-4 6/1165 33/18722 0.0149255973253526 0.0788864197619626 GATA3/HSP90AB1/HSPA5/RPLP0/TUBA1B/IMPDH2 6 GO:1903146 regulation of autophagy of mitochondrion 6/1165 33/18722 0.0149255973253526 0.0788864197619626 BNIP3L/SLC25A5/PARK7/TSPO/BNIP3/VDAC1 6 GO:0009896 positive regulation of catabolic process 43/1165 492/18722 0.0154550654714203 0.0813996292397839 LRP2/LIN28B/GJA1/APP/LAPTM5/GPC3/DDB1/KCNQ1OT1/BNIP3L/APOE/HSP90AA1/ZFP36/SESN1/MAGEF1/OAZ1/VCP/DAB2/BAG2/SCOC/SLC25A5/PSMC1/PSMC3/DHX36/MYLIP/PIK3C2A/PSMC6/MSN/MDM2/TREM2/PARK7/TRIM22/WWP1/PABPC1/BAD/PSMC4/UFL1/BNIP3/ZFP36L1/VDAC1/ADAM8/LRP1/SORL1/TNFRSF1B 43 GO:0022617 extracellular matrix disassembly 9/1165 63/18722 0.0154736156064225 0.0813996292397839 DPP4/CTSV/LAMC1/CTSS/LCP1/CST3/TGFB1/ADAM8/LRP1 9 GO:1904589 regulation of protein import 9/1165 63/18722 0.0154736156064225 0.0813996292397839 CDH1/FERMT1/GLI3/HSP90AB1/FLNA/RAN/TGFB1/HSPA8/JAK2 9 GO:2000242 negative regulation of reproductive process 9/1165 63/18722 0.0154736156064225 0.0813996292397839 BMP7/GJA1/SERPINF1/TIMP1/PRDX4/DUSP1/PRKACB/ARHGDIB/CALR 9 GO:2000756 regulation of peptidyl-lysine acetylation 9/1165 63/18722 0.0154736156064225 0.0813996292397839 ISL1/GATA3/SOX4/HINT2/SPI1/BRD7/PARK7/HDAC2/SET 9 GO:0001823 mesonephros development 12/1165 96/18722 0.0158559743019953 0.0833329435927899 LAMA5/MAGED1/PBX1/BMP7/LGR4/TACSTD2/GATA3/GLI3/GPC3/DLG1/VEGFA/BASP1 12 GO:0008202 steroid metabolic process 30/1165 319/18722 0.0159287063743675 0.0836129270701108 LRP2/HSD17B1/SLC27A2/PBX1/LRP5/APP/SOD1/DHCR24/PRLR/LIMA1/FDFT1/APOE/COMT/AKR1B1/LGMN/FDPS/HINT2/APOC1/OSBPL9/PMVK/CYB5R1/FDX1/HSD17B11/SF1/LIPA/ACBD3/TSPO/CGA/ACADVL/APOBR 30 GO:1904591 positive regulation of protein import 7/1165 43/18722 0.0159815887079766 0.0836129270701108 CDH1/GLI3/HSP90AB1/FLNA/RAN/TGFB1/JAK2 7 GO:0003151 outflow tract morphogenesis 10/1165 74/18722 0.0159837289767021 0.0836129270701108 LRP2/TGFBR3/GJA5/BMP7/ISL1/NRP2/FOLR1/TBX3/NRP1/VEGFA 10 GO:0006635 fatty acid beta-oxidation 10/1165 74/18722 0.0159837289767021 0.0836129270701108 SLC27A2/ECHDC2/ECHS1/ECI1/ECI2/ETFA/ECH1/HADHB/ACADVL/ECHDC1 10 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 10/1165 74/18722 0.0159837289767021 0.0836129270701108 ISL1/PARP1/YAP1/SKP2/DAB2/RHOA/PARK7/CALR/PHB/UFL1 10 GO:0019827 stem cell population maintenance 15/1165 131/18722 0.0162376653206585 0.0848622117736093 BMP7/LRP5/ASPM/TBX3/YAP1/PTN/SOX4/SPI1/KLF4/GNL3/NCOA3/RTF1/PCM1/ZC3H13/SMC3 15 GO:0030010 establishment of cell polarity 16/1165 143/18722 0.0163584072031592 0.0854137112849608 KANK1/FERMT1/JAM3/GJA1/GATA3/PRKCZ/FRMD4A/AMOT/HSP90AB1/WEE1/MPP7/FRMD4B/HSP90AA1/ITGB1/RHOA/MSN 16 GO:0032872 regulation of stress-activated MAPK cascade 20/1165 192/18722 0.0165612674039434 0.0862693851561683 EGFR/PAGE4/APP/MARVELD3/IGF1R/NCF1/DUSP1/PDCD4/PRDX1/DLG1/VEGFA/GSTP1/SPI1/PYCARD/ARL6IP5/GADD45G/TREM2/HRAS/PPIA/PRMT1 20 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 30/1165 320/18722 0.0165683942986548 0.0862693851561683 MBNL3/MBNL2/NPM1/SNRPF/C1QBP/SNRPA1/LSM7/SNRPG/SNU13/LSM3/DDX1/MFAP1/PABPC1/SNRPD1/RBM39/PRDX6/RBM17/SF3B6/SNRPE/SNRPB2/SNRPD2/SF1/SNRPD3/NCL/SRSF2/RBM3/HSPA8/CIRBP/SNRPC/SON 30 GO:0000398 mRNA splicing, via spliceosome 30/1165 320/18722 0.0165683942986548 0.0862693851561683 MBNL3/MBNL2/NPM1/SNRPF/C1QBP/SNRPA1/LSM7/SNRPG/SNU13/LSM3/DDX1/MFAP1/PABPC1/SNRPD1/RBM39/PRDX6/RBM17/SF3B6/SNRPE/SNRPB2/SNRPD2/SF1/SNRPD3/NCL/SRSF2/RBM3/HSPA8/CIRBP/SNRPC/SON 30 GO:0048568 embryonic organ development 38/1165 427/18722 0.016890756031419 0.087866370346946 FBN1/FBN2/NR2F2/EFEMP1/PBX1/BMP7/SPINT1/KRT8/TEAD1/PHLDA2/SPINT2/FOLR1/GATA3/ATP6V1B1/TFAP2A/GLI3/SOD1/EPAS1/TBX3/EFNA1/YAP1/MYO7A/MFAP5/CEBPB/DLG1/DLX5/SLC39A1/VEGFA/GRB2/JUNB/TGFB1/KRT19/RAD23B/TRIOBP/IGF2/MBD2/ZFP36L1/SOCS3 38 GO:0030104 water homeostasis 9/1165 64/18722 0.017043205934763 0.0883319620607798 MET/CLDN4/LSR/ATP6V1B1/AKR1B1/PRKACB/STMN1/CLN3/AQP9 9 GO:0045670 regulation of osteoclast differentiation 9/1165 64/18722 0.017043205934763 0.0883319620607798 FBN1/TYROBP/CEBPB/FOS/ESRRA/TREM2/LILRB4/LILRB1/LILRB3 9 GO:0080164 regulation of nitric oxide metabolic process 9/1165 64/18722 0.017043205934763 0.0883319620607798 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/ATP2B4/TSPO/JAK2 9 GO:1903409 reactive oxygen species biosynthetic process 9/1165 64/18722 0.017043205934763 0.0883319620607798 PAGE4/SOD2/HSPD1/SOD1/CYBA/NCF1/SLC5A3/RHOA/PARK7 9 GO:0070167 regulation of biomineral tissue development 12/1165 97/18722 0.0171047595653999 0.0883439457642771 FBN2/SRGN/BMP7/ISG15/TFAP2A/NOTUM/PTN/ATP2B1/CEBPB/TGFB1/SLC8A1/ATRAID 12 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 12/1165 97/18722 0.0171047595653999 0.0883439457642771 ITGA6/YAP1/NRP1/PRDX2/GCLM/GPX1/SIAH2/IFI6/GSTP1/LGALS3/PARK7/PEA15 12 GO:1902806 regulation of cell cycle G1/S phase transition 18/1165 168/18722 0.0171433155077601 0.0883439457642771 EGFR/ADAMTS1/CTDSPL/WEE1/AIF1/CCND3/PSME2/DLG1/PRKDC/SOX4/CCND1/KLF4/ATP2B4/BRD7/PTPN6/MDM2/PSME1/APEX1 18 GO:2000241 regulation of reproductive process 18/1165 168/18722 0.0171433155077601 0.0883439457642771 BMP7/GJA1/PHLDA2/SERPINF1/TIMP1/PRDX4/ASPM/DUSP1/VEGFA/PRKACB/C1QBP/CIB1/RETN/ARHGDIB/HDAC2/CALR/DEFB1/LHFPL2 18 GO:0000096 sulfur amino acid metabolic process 6/1165 34/18722 0.0171955517778848 0.0883439457642771 SMS/COMT/GCLM/CDO1/ADI1/MTR 6 GO:0032743 positive regulation of interleukin-2 production 6/1165 34/18722 0.0171955517778848 0.0883439457642771 PTPRC/CD86/STOML2/RPS3/PNP/CD83 6 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 6/1165 34/18722 0.0171955517778848 0.0883439457642771 CD44/NPM1/PMAIP1/CD74/SMYD2/MDM2 6 GO:0050869 negative regulation of B cell activation 6/1165 34/18722 0.0171955517778848 0.0883439457642771 TYROBP/PAWR/LAPTM5/MNDA/CD300A/LYN 6 GO:0086004 regulation of cardiac muscle cell contraction 6/1165 34/18722 0.0171955517778848 0.0883439457642771 GJA5/DSP/DSG2/DSC2/DLG1/AKAP9 6 GO:0035902 response to immobilization stress 5/1165 25/18722 0.0173130839730456 0.0883439457642771 SOD2/FOXO4/FOS/MDM2/SLC8A1 5 GO:0046039 GTP metabolic process 5/1165 25/18722 0.0173130839730456 0.0883439457642771 RHOA/RAN/AK3/NME1/IMPDH2 5 GO:0051204 protein insertion into mitochondrial membrane 5/1165 25/18722 0.0173130839730456 0.0883439457642771 HSP90AA1/TIMM13/NMT1/ROMO1/TIMM8B 5 GO:0060706 cell differentiation involved in embryonic placenta development 5/1165 25/18722 0.0173130839730456 0.0883439457642771 NR2F2/KRT8/SPINT2/KRT19/SOCS3 5 GO:0090330 regulation of platelet aggregation 5/1165 25/18722 0.0173130839730456 0.0883439457642771 CD9/IL6ST/SYK/JAK2/LYN 5 GO:0098581 detection of external biotic stimulus 5/1165 25/18722 0.0173130839730456 0.0883439457642771 HLA-B/HLA-A/HLA-DRB1/TREM2/TLR2 5 GO:1901798 positive regulation of signal transduction by p53 class mediator 5/1165 25/18722 0.0173130839730456 0.0883439457642771 RPL23/PMAIP1/UBB/RPL37/RPS7 5 GO:1905048 regulation of metallopeptidase activity 5/1165 25/18722 0.0173130839730456 0.0883439457642771 CLDN4/TIMP3/TIMP1/LRP1/SORL1 5 GO:0014065 phosphatidylinositol 3-kinase signaling 16/1165 144/18722 0.0173779272725998 0.0884336407806914 EGFR/GATA3/ERBB3/FLT1/IGF1R/NCF1/C1QBP/PIK3C2A/KLF4/PTPN6/TREM2/HCST/MYDGF/FGR/ZFP36L1/JAK2 16 GO:0106106 cold-induced thermogenesis 16/1165 144/18722 0.0173779272725998 0.0884336407806914 LGR4/ADRB1/GJA1/CXCR4/EPAS1/ESRRG/IGF1R/PRLR/GNAS/ID1/CEBPB/VEGFA/PLAC8/GADD45G/SYK/JAK2 16 GO:0120161 regulation of cold-induced thermogenesis 16/1165 144/18722 0.0173779272725998 0.0884336407806914 LGR4/ADRB1/GJA1/CXCR4/EPAS1/ESRRG/IGF1R/PRLR/GNAS/ID1/CEBPB/VEGFA/PLAC8/GADD45G/SYK/JAK2 16 GO:0048864 stem cell development 11/1165 86/18722 0.0174233875888785 0.0885846689641078 SEMA6A/LAMA5/SEMA6D/BMP7/ISL1/NRP2/FOLR1/MSI2/NRP1/PTPRC/PDCD6 11 GO:0034121 regulation of toll-like receptor signaling pathway 10/1165 75/18722 0.0174482313255337 0.0886306990318741 LGR4/CYBA/IRF1/TREM2/IRF7/RSAD2/TLR2/CD300A/LILRA2/LYN 10 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/1165 54/18722 0.0178105344083163 0.0901447516987191 HLA-F/PTPRC/IL4I1/CD55/CD46/PTPN6/LILRB4/LILRB1 8 GO:0006968 cellular defense response 8/1165 54/18722 0.0178105344083163 0.0901447516987191 TYROBP/LSP1/NCF2/NCF1/ITGB1/LILRB2/MNDA/LGALS3BP 8 GO:0070839 metal ion export 8/1165 54/18722 0.0178105344083163 0.0901447516987191 SLC40A1/SLC9A1/ATP2B1/DLG1/ATP2B4/SLC11A1/YWHAE/SLC8A1 8 GO:2000179 positive regulation of neural precursor cell proliferation 8/1165 54/18722 0.0178105344083163 0.0901447516987191 LRP2/ADGRG1/GLI3/ASPM/VEGFA/FLNA/GNAI2/LYN 8 GO:0009262 deoxyribonucleotide metabolic process 7/1165 44/18722 0.0180146672029513 0.0910137956887181 TYMP/UPP1/ADK/TYMS/DNPH1/PNP/DUT 7 GO:0060711 labyrinthine layer development 7/1165 44/18722 0.0180146672029513 0.0910137956887181 BMP7/SPINT1/SPINT2/GRB2/JUNB/ZFP36L1/SOCS3 7 GO:0001837 epithelial to mesenchymal transition 17/1165 157/18722 0.018332726247815 0.0918496584590162 TGFBR3/BMP7/DAG1/ISL1/DLG5/GATA3/S100A4/FERMT2/TBX3/EFNA1/PDCD4/HNRNPAB/DAB2/FLNA/TGFB1/HDAC2/PDCD6 17 GO:0022411 cellular component disassembly 39/1165 443/18722 0.0183339031021381 0.0918496584590162 DPP4/CTSV/LAMC1/CTSS/SCIN/DSTN/IGF1R/LIMA1/RPL23/BNIP3L/C1QA/LCP1/C1QB/VCP/C1QC/BLCAP/SLC25A5/EPS8/CST3/CIB1/TGFB1/TREM2/PARK7/TRIOBP/STMN1/VMP1/UFL1/ADD3/SET/FIS1/CLN3/TSPO/BNIP3/HSPA8/VDAC1/ADAM8/LRP1/GABARAPL1/TOP2A 39 GO:0032642 regulation of chemokine production 12/1165 98/18722 0.018426077676125 0.0918496584590162 APP/AIF1/GSTP1/KLF4/CD74/PYCARD/TREM2/LILRB4/OAS1/TLR2/SYK/LRP1 12 GO:0070301 cellular response to hydrogen peroxide 12/1165 98/18722 0.018426077676125 0.0918496584590162 MET/PAWR/KLF2/NET1/KLF4/STK26/MDM2/PARK7/HDAC2/APEX1/BNIP3/RPS3 12 GO:1904029 regulation of cyclin-dependent protein kinase activity 12/1165 98/18722 0.018426077676125 0.0918496584590162 EGFR/NR2F2/CDKN1C/HSP90AB1/CCND3/CCNE1/LATS2/CCND1/CKS2/CKS1B/ACTB/CCNB1 12 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 12/1165 98/18722 0.018426077676125 0.0918496584590162 SOD2/CD44/HELLS/GPX1/PLAUR/CD74/MDM2/PARK7/ENO1/USP47/PPIA/NDUFS3 12 GO:0061351 neural precursor cell proliferation 16/1165 145/18722 0.0184456096450152 0.0918496584590162 LRP2/ADGRG1/SPINT1/SLC6A4/SPINT2/GLI3/ASPM/PTN/RHOA/VEGFA/FLNA/ATF5/PSMG1/PCM1/GNAI2/LYN 16 GO:0010715 regulation of extracellular matrix disassembly 4/1165 17/18722 0.0184910233491339 0.0918496584590162 DPP4/CST3/TGFB1/LRP1 4 GO:0010934 macrophage cytokine production 4/1165 17/18722 0.0184910233491339 0.0918496584590162 LAPTM5/CD74/TGFB1/LILRB1 4 GO:0010935 regulation of macrophage cytokine production 4/1165 17/18722 0.0184910233491339 0.0918496584590162 LAPTM5/CD74/TGFB1/LILRB1 4 GO:0016045 detection of bacterium 4/1165 17/18722 0.0184910233491339 0.0918496584590162 HLA-B/HLA-A/HLA-DRB1/TLR2 4 GO:0020027 hemoglobin metabolic process 4/1165 17/18722 0.0184910233491339 0.0918496584590162 SLC25A37/EIF2AK1/KLF4/PRMT1 4 GO:0038065 collagen-activated signaling pathway 4/1165 17/18722 0.0184910233491339 0.0918496584590162 COL4A2/OSCAR/SYK/JAK2 4 GO:0043117 positive regulation of vascular permeability 4/1165 17/18722 0.0184910233491339 0.0918496584590162 TJP1/APOE/VEGFA/TGFB1 4 GO:0048532 anatomical structure arrangement 4/1165 17/18722 0.0184910233491339 0.0918496584590162 NRP2/TFAP2A/NRP1/HSPA5 4 GO:0060977 coronary vasculature morphogenesis 4/1165 17/18722 0.0184910233491339 0.0918496584590162 LRP2/TGFBR3/NRP1/VEGFA 4 GO:0072673 lamellipodium morphogenesis 4/1165 17/18722 0.0184910233491339 0.0918496584590162 KANK1/CD44/WASF2/PLEKHO1 4 GO:0090713 immunological memory process 4/1165 17/18722 0.0184910233491339 0.0918496584590162 HLA-DRA/FGL2/HLA-DRB1/CD46 4 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 4/1165 17/18722 0.0184910233491339 0.0918496584590162 GATA3/CD24/YAP1/STAT1 4 GO:0098656 anion transmembrane transport 24/1165 245/18722 0.018661659672096 0.0926152924310121 LRP2/TCAF1/SLC26A2/SLC16A12/GJA1/SLC13A4/GABRE/FOLR1/SLC38A9/SLC19A1/SLC35B4/SLC13A3/SLC9A1/SLC25A3/ITGB1/MPC2/SLC25A5/SLC5A6/ARL6IP5/SLC1A3/SLC16A3/SLC25A13/SLC25A1/VDAC1 24 GO:0048524 positive regulation of viral process 9/1165 65/18722 0.0187258832957794 0.092851928391528 HACD3/DDB1/P4HB/HLA-DRB1/CD74/PABPC1/PPIA/IFIT1/TOP2A 9 GO:0048041 focal adhesion assembly 11/1165 87/18722 0.0188622724461815 0.0934456621715947 SORBS1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/TRIP6/LIMS1/PTPRA/LRP1 11 GO:1901987 regulation of cell cycle phase transition 35/1165 390/18722 0.018933222865188 0.0937144443935627 EGFR/PBX1/ADAMTS1/CTDSPL/APP/WEE1/DDB1/AIF1/DUSP1/BRD4/CCND3/NPM1/PSME2/DLG1/FOXO4/PRKDC/SOX4/ATF5/EIF2AK4/CCND1/KLF4/ATP2B4/BRD7/PTPN6/ANAPC11/MDM2/CENPF/USP47/PSME1/RAD21/APEX1/BABAM1/ZFP36L1/RAB11A/CCNB1 35 GO:0006809 nitric oxide biosynthetic process 10/1165 76/18722 0.0190093571150687 0.0937605636967315 ASS1/HSP90AB1/KLF2/AIF1/HSP90AA1/KLF4/ATP2B4/GCH1/TSPO/JAK2 10 GO:0008652 cellular amino acid biosynthetic process 10/1165 76/18722 0.0190093571150687 0.0937605636967315 ASS1/ADI1/ASNSD1/MTR/ATP2B4/SLC1A3/PARK7/AASDHPPT/GLUL/CLN3 10 GO:0014823 response to activity 10/1165 76/18722 0.0190093571150687 0.0937605636967315 COL4A2/SOD2/CXCR4/HSPD1/CYBA/PTN/GCLM/PRKDC/FIS1/SCO2 10 GO:0045685 regulation of glial cell differentiation 10/1165 76/18722 0.0190093571150687 0.0937605636967315 SPINT1/DAG1/CXCR4/PTN/IL6ST/TGFB1/TREM2/HDAC2/TLR2/TNFRSF1B 10 GO:0014812 muscle cell migration 13/1165 110/18722 0.0190764589093666 0.0940089234927784 SEMA6D/ADAMTS1/NRP1/AIF1/NET1/FOXO4/RHOA/GSTP1/MDM2/PLEKHO1/APEX1/LRP1/SORL1 13 GO:0030073 insulin secretion 20/1165 195/18722 0.0192877218497268 0.0949666515285231 DPP4/LRP5/GJA1/ISL1/FAM3B/SYT7/MPC2/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/PARK7/UQCC2/CCDC186/BAD/GLUL/LRP1/JAK2/ENSA 20 GO:0000375 RNA splicing, via transesterification reactions 30/1165 324/18722 0.0193351219051524 0.0951165988200003 MBNL3/MBNL2/NPM1/SNRPF/C1QBP/SNRPA1/LSM7/SNRPG/SNU13/LSM3/DDX1/MFAP1/PABPC1/SNRPD1/RBM39/PRDX6/RBM17/SF3B6/SNRPE/SNRPB2/SNRPD2/SF1/SNRPD3/NCL/SRSF2/RBM3/HSPA8/CIRBP/SNRPC/SON 30 GO:0046700 heterocycle catabolic process 39/1165 445/18722 0.0195572266005474 0.0958768957038132 TYMP/LIN28B/QPRT/APOBEC3A/KCNQ1OT1/HINT1/NUDT4/RNASET2/NPM1/SLIRP/ZFP36/VCP/IL4I1/VIM/UPP1/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/SLCO2B1/PABPC1/KYNU/OAS2/YBX1/SND1/NUDT5/DNPH1/APEX1/ZFP36L1/PNRC2/MGAT1/CIRBP/PNP/DUT/TNFRSF1B 39 GO:0007043 cell-cell junction assembly 16/1165 146/18722 0.0195628296217589 0.0958768957038132 GJA5/CLDN4/JAM3/LSR/GJA1/DLG5/TJP1/MARVELD3/MPP7/PARD6B/CLDN7/DLG1/PECAM1/RHOA/CD9/ACTB 16 GO:0048511 rhythmic process 28/1165 298/18722 0.0195677612095272 0.0958768957038132 EGFR/MAGED1/ADAMTS1/CLDN4/LGR4/SLC6A4/ADRB1/SERPINF1/NR2F6/ASS1/DDB1/PTN/ID1/GNA11/HSPA5/SIAH2/GFPT1/PRKDC/ATF5/OPN3/BHLHE41/RETN/CREM/HDAC2/TYMS/IMPDH2/JUN/TOP2A 28 GO:0001508 action potential 15/1165 134/18722 0.0195921609428601 0.0958768957038132 GJA5/DSP/DSG2/GJA1/USP53/ANK3/DSC2/SLC9A1/DLG1/GNA11/FLNA/AKAP9/YWHAE/CLN3/SLC8A1 15 GO:0042552 myelination 15/1165 134/18722 0.0195921609428601 0.0958768957038132 ITGB4/TYMP/DAG1/JAM3/CXCR4/CMTM8/SOD1/GPC1/PTN/DEGS1/DLG1/AFG3L2/CD9/TLR2/TNFRSF1B 15 GO:0098727 maintenance of cell number 15/1165 134/18722 0.0195921609428601 0.0958768957038132 BMP7/LRP5/ASPM/TBX3/YAP1/PTN/SOX4/SPI1/KLF4/GNL3/NCOA3/RTF1/PCM1/ZC3H13/SMC3 15 GO:0046640 regulation of alpha-beta T cell proliferation 6/1165 35/18722 0.0196918264928907 0.0961071672539697 HLA-A/HLA-E/PTPRC/CD55/IRF1/SYK 6 GO:0000768 syncytium formation by plasma membrane fusion 8/1165 55/18722 0.0197419497316635 0.0961071672539697 ERVW-1/TYROBP/CD9/GDF15/TREM2/PLEKHO1/CD53/CXCL10 8 GO:0001755 neural crest cell migration 8/1165 55/18722 0.0197419497316635 0.0961071672539697 SEMA6A/LAMA5/SEMA6D/BMP7/ISL1/NRP2/FOLR1/NRP1 8 GO:0042220 response to cocaine 8/1165 55/18722 0.0197419497316635 0.0961071672539697 HSPD1/HSP90AB1/HSPA5/TGM2/DNMT3A/SLC1A3/MDM2/HDAC2 8 GO:0098900 regulation of action potential 8/1165 55/18722 0.0197419497316635 0.0961071672539697 GJA5/DSP/DSG2/DSC2/SLC9A1/DLG1/FLNA/AKAP9 8 GO:0140253 cell-cell fusion 8/1165 55/18722 0.0197419497316635 0.0961071672539697 ERVW-1/TYROBP/CD9/GDF15/TREM2/PLEKHO1/CD53/CXCL10 8 GO:0110149 regulation of biomineralization 12/1165 99/18722 0.0198223142549448 0.0964147746213215 FBN2/SRGN/BMP7/ISG15/TFAP2A/NOTUM/PTN/ATP2B1/CEBPB/TGFB1/SLC8A1/ATRAID 12 GO:0006006 glucose metabolic process 20/1165 196/18722 0.0202699420398556 0.0982871796593005 LRP5/PHLDA2/SORBS1/SLC35B4/DDB1/GAPDH/FBP1/TPI1/PMAIP1/PGP/DCXR/SERP1/PGK1/ENO1/OAS1/SLC25A13/IGF2/BAD/SLC25A1/FAM3C 20 GO:0002710 negative regulation of T cell mediated immunity 5/1165 26/18722 0.0203654143530974 0.0982871796593005 HLA-F/PTPRC/IL4I1/LILRB4/LILRB1 5 GO:0046697 decidualization 5/1165 26/18722 0.0203654143530974 0.0982871796593005 CTSV/GJA1/BSG/PTN/JUNB 5 GO:0070102 interleukin-6-mediated signaling pathway 5/1165 26/18722 0.0203654143530974 0.0982871796593005 YAP1/SPI1/IL6ST/JAK1/JAK2 5 GO:1904376 negative regulation of protein localization to cell periphery 5/1165 26/18722 0.0203654143530974 0.0982871796593005 GBP1/DAB2/CLTC/TGFB1/ABI3 5 GO:1901657 glycosyl compound metabolic process 11/1165 88/18722 0.0203873483009129 0.0982871796593005 TYMP/APOBEC3A/AKR1B1/FUCA1/UPP1/ATIC/ADK/FUCA2/OARD1/DNPH1/PNP 11 GO:0046626 regulation of insulin receptor signaling pathway 9/1165 66/18722 0.0205258331496837 0.0982871796593005 KANK1/SORBS1/PRKCZ/CCND3/NUCKS1/IGF2/GNAI2/SOCS3/SORL1 9 GO:0050766 positive regulation of phagocytosis 9/1165 66/18722 0.0205258331496837 0.0982871796593005 SOD1/CYBA/FCER1G/PTPRC/PYCARD/SLC11A1/TREM2/CALR/LRP1 9 GO:0051893 regulation of focal adhesion assembly 9/1165 66/18722 0.0205258331496837 0.0982871796593005 FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/LIMS1/PTPRA/LRP1 9 GO:0072678 T cell migration 9/1165 66/18722 0.0205258331496837 0.0982871796593005 APP/AIF1/RHOA/PYCARD/MSN/MYO1G/CXCL10/CXCL16/ADAM8 9 GO:0090109 regulation of cell-substrate junction assembly 9/1165 66/18722 0.0205258331496837 0.0982871796593005 FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/LIMS1/PTPRA/LRP1 9 GO:0001820 serotonin secretion 3/1165 10/18722 0.0207287183822255 0.0982871796593005 SLC6A4/LILRB1/SYK 3 GO:0002934 desmosome organization 3/1165 10/18722 0.0207287183822255 0.0982871796593005 DSP/DSG2/PERP 3 GO:0010944 negative regulation of transcription by competitive promoter binding 3/1165 10/18722 0.0207287183822255 0.0982871796593005 TFAP2A/BHLHE41/PHB 3 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 3/1165 10/18722 0.0207287183822255 0.0982871796593005 NPM1/EIF2AK1/EIF2AK4 3 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 3/1165 10/18722 0.0207287183822255 0.0982871796593005 GATA3/GDF15/SULF2 3 GO:0036363 transforming growth factor beta activation 3/1165 10/18722 0.0207287183822255 0.0982871796593005 LTBP1/HSP90AB1/ITGB8 3 GO:0042989 sequestering of actin monomers 3/1165 10/18722 0.0207287183822255 0.0982871796593005 TMSB4X/SCIN/TMSB10 3 GO:0051409 response to nitrosative stress 3/1165 10/18722 0.0207287183822255 0.0982871796593005 ADH5/GCLM/PARK7 3 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 3/1165 10/18722 0.0207287183822255 0.0982871796593005 PTPRC/PLSCR1/LYN 3 GO:0070391 response to lipoteichoic acid 3/1165 10/18722 0.0207287183822255 0.0982871796593005 CD14/TREM2/TLR2 3 GO:0071223 cellular response to lipoteichoic acid 3/1165 10/18722 0.0207287183822255 0.0982871796593005 CD14/TREM2/TLR2 3 GO:0071803 positive regulation of podosome assembly 3/1165 10/18722 0.0207287183822255 0.0982871796593005 LCP1/RHOA/MSN 3 GO:0072203 cell proliferation involved in metanephros development 3/1165 10/18722 0.0207287183822255 0.0982871796593005 BMP7/GPC3/STAT1 3 GO:0097278 complement-dependent cytotoxicity 3/1165 10/18722 0.0207287183822255 0.0982871796593005 HSP90AB1/CD59/CD55 3 GO:1902946 protein localization to early endosome 3/1165 10/18722 0.0207287183822255 0.0982871796593005 NRP1/MSN/SORL1 3 GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3/1165 10/18722 0.0207287183822255 0.0982871796593005 EFNA1/SORL1/LYN 3 GO:2000510 positive regulation of dendritic cell chemotaxis 3/1165 10/18722 0.0207287183822255 0.0982871796593005 C1QBP/SPI1/CALR 3 GO:0001889 liver development 16/1165 147/18722 0.0207309582873556 0.0982871796593005 EGFR/MET/TGFBR3/KRT18/LSR/GLI3/ASS1/ARID5B/PTN/CEBPB/CCND1/HRAS/RPS16/TYMS/ACO2/SULF2 16 GO:0030168 platelet activation 14/1165 123/18722 0.0207325887611993 0.0982871796593005 FCER1G/APOE/GNAS/VAV3/FLNA/CD9/PLSCR1/IL6ST/PTPN6/PPIA/ACTB/SYK/JAK2/LYN 14 GO:0045930 negative regulation of mitotic cell cycle 23/1165 235/18722 0.0211559926346472 0.100209777770696 EGFR/BMP7/CTDSPL/CDKN1C/BTG3/WEE1/DUSP1/DLG1/FOXO4/PRKDC/AURKAIP1/SOX4/CCND1/KLF4/BRD7/TGFB1/MDM2/CENPF/USP47/RAD21/BABAM1/ZFP36L1/CCNB1 23 GO:0021537 telencephalon development 24/1165 248/18722 0.0212793989831839 0.10070218540317 ADGRG1/LAMB1/TACC2/SLC2A1/GNG12/CXCR4/CDK6/GLI3/ASPM/UQCRQ/ANXA3/DLX5/RHOA/FLNA/ATF5/ATP2B4/ATIC/BCL2A1/C12orf57/BAD/NME1/BNIP3/SLC8A1/LRP1 24 GO:0009062 fatty acid catabolic process 12/1165 100/18722 0.021295830050519 0.10070218540317 SLC27A2/ECHDC2/ECHS1/PCCB/AIG1/ECI1/ECI2/ETFA/ECH1/HADHB/ACADVL/ECHDC1 12 GO:0140694 non-membrane-bounded organelle assembly 33/1165 367/18722 0.0216263748258901 0.102179159846566 KRT8/ASPM/RPSA/OBSL1/CSRP2/RPS27/NPM1/ITGB1/TUBB/LCP1/RPLP0/PRKDC/RHOA/RPS23/C1QBP/FLNA/RPS28/RPS5/LSM3/MRPL20/RPS14/RPL5/MSN/BRIX1/PRRC2C/KRT19/CENPF/HCK/MRPS7/RAB11A/RPS3/CIRBP/SMC3 33 GO:0035637 multicellular organismal signaling 17/1165 160/18722 0.0216625555226108 0.102264023674024 GJA5/DSP/DSG2/TYMP/JAM3/GJA1/ISL1/ANK3/DSC2/SOD1/SLC9A1/ATP2B1/FLNA/ATP2B4/AKAP9/YWHAE/SLC8A1 17 GO:0071385 cellular response to glucocorticoid stimulus 8/1165 56/18722 0.0218178607948024 0.102824225559383 EGFR/ISL1/SERPINF1/ASS1/ZFP36/ATP2B1/GSTP1/ZFP36L1 8 GO:1904645 response to amyloid-beta 8/1165 56/18722 0.0218178607948024 0.102824225559383 GJA1/APP/PARP1/IGF1R/LGMN/TREM2/SNX6/LRP1 8 GO:0015711 organic anion transport 32/1165 354/18722 0.0219248703702259 0.103241860224898 LRP2/SLC26A2/SLC2A1/SLC16A12/SLC38A1/GJA1/SLC22A11/FOLR1/SLC38A9/SLC19A1/SLC52A1/PTGES/SLC35B4/SLC13A3/ITGB1/MPC2/SLC25A5/SLC5A6/SLC11A1/ARL6IP5/SLC1A3/SLC29A1/SLC2A3/SLCO2B1/SLC16A3/CYB5R1/SLC25A13/SLC25A1/CLN3/SYK/AQP9/SLC7A7 32 GO:0044839 cell cycle G2/M phase transition 16/1165 148/18722 0.0219513604606184 0.103279954958467 PBX1/APP/WEE1/BRD4/NPM1/SKP2/FOXO4/ATF5/CCND1/CENPF/USP47/RAD21/BABAM1/RAB11A/CCNB1/ENSA 16 GO:0014910 regulation of smooth muscle cell migration 11/1165 89/18722 0.0220013903764558 0.103428646719469 SEMA6D/ADAMTS1/NRP1/AIF1/FOXO4/RHOA/GSTP1/MDM2/APEX1/LRP1/SORL1 11 GO:0009132 nucleoside diphosphate metabolic process 14/1165 124/18722 0.0220824763875472 0.103480916634049 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/DLG1/AK3/PGK1/PKM/ENO1/BAD/NUDT5/NME1 14 GO:0007272 ensheathment of neurons 15/1165 136/18722 0.0221046889442767 0.103480916634049 ITGB4/TYMP/DAG1/JAM3/CXCR4/CMTM8/SOD1/GPC1/PTN/DEGS1/DLG1/AFG3L2/CD9/TLR2/TNFRSF1B 15 GO:0008366 axon ensheathment 15/1165 136/18722 0.0221046889442767 0.103480916634049 ITGB4/TYMP/DAG1/JAM3/CXCR4/CMTM8/SOD1/GPC1/PTN/DEGS1/DLG1/AFG3L2/CD9/TLR2/TNFRSF1B 15 GO:0043401 steroid hormone mediated signaling pathway 15/1165 136/18722 0.0221046889442767 0.103480916634049 BMP7/ISL1/PARP1/ESRRG/YAP1/SKP2/DAB2/RHOA/ESRRA/PARK7/CALR/PHB/UFL1/PGRMC2/JAK2 15 GO:0045727 positive regulation of translation 15/1165 136/18722 0.0221046889442767 0.103480916634049 NPM1/PRKDC/RHOA/SOX4/C1QBP/VIM/DHX36/EIF2AK4/SERP1/RPL5/PKM/UQCC2/PABPC1/RBM3/CIRBP 15 GO:0043270 positive regulation of ion transport 26/1165 275/18722 0.0222148565176516 0.103909991361315 TCAF1/SLC6A4/CTSS/TMSB4X/ANK3/PTGES/PRSS8/KCNN4/IFNGR2/SLC9A1/ITGB1/ATP2B1/CEBPB/DLG1/FLNA/LGALS3/AKAP9/GSTO1/TREM2/GLRX/VMP1/CXCL10/CCL4/TSPO/NDUFA4/LILRA2 26 GO:0051385 response to mineralocorticoid 6/1165 36/18722 0.0224235198486315 0.104244595646881 PARP1/CYBA/CYBB/ATP2B1/FOS/CCND1 6 GO:0060251 regulation of glial cell proliferation 6/1165 36/18722 0.0224235198486315 0.104244595646881 EGFR/PTN/ETV5/UFL1/TSPO/LYN 6 GO:0070670 response to interleukin-4 6/1165 36/18722 0.0224235198486315 0.104244595646881 GATA3/HSP90AB1/HSPA5/RPLP0/TUBA1B/IMPDH2 6 GO:1903539 protein localization to postsynaptic membrane 6/1165 36/18722 0.0224235198486315 0.104244595646881 DAG1/NSG1/PRKCZ/DLG1/HRAS/RAB11A 6 GO:0019319 hexose biosynthetic process 10/1165 78/18722 0.0224349673154164 0.104244595646881 SLC35B4/DDB1/FBP1/AKR1B1/TPI1/PGP/PGK1/SLC25A13/SLC25A1/FAM3C 10 GO:0032024 positive regulation of insulin secretion 10/1165 78/18722 0.0224349673154164 0.104244595646881 GJA1/ISL1/MPC2/HLA-DRB1/SOX4/SERP1/BAD/GLUL/LRP1/JAK2 10 GO:0043297 apical junction assembly 10/1165 78/18722 0.0224349673154164 0.104244595646881 CLDN4/GJA1/DLG5/TJP1/MARVELD3/MPP7/CLDN7/DLG1/PECAM1/RHOA 10 GO:0090559 regulation of membrane permeability 10/1165 78/18722 0.0224349673154164 0.104244595646881 JAM3/LAPTM5/SLC9A1/BNIP3L/PMAIP1/HEBP2/SLC25A5/NMT1/BAD/BNIP3 10 GO:0042398 cellular modified amino acid biosynthetic process 7/1165 46/18722 0.0226126942933933 0.104285024400831 ALDH7A1/CKMT1B/GCLM/PLSCR1/ATIC/PARK7/GCH1 7 GO:0043300 regulation of leukocyte degranulation 7/1165 46/18722 0.0226126942933933 0.104285024400831 STXBP2/HLA-F/SPI1/FGR/SYK/CD300A/LYN 7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 7/1165 46/18722 0.0226126942933933 0.104285024400831 EGFR/ADAMTS1/AIF1/CCND3/CCND1/MDM2/APEX1 7 GO:0009125 nucleoside monophosphate catabolic process 4/1165 18/18722 0.0226294601318747 0.104285024400831 TYMP/UPP1/DNPH1/PNP 4 GO:0034134 toll-like receptor 2 signaling pathway 4/1165 18/18722 0.0226294601318747 0.104285024400831 CYBA/TREM2/TLR2/LYN 4 GO:0048268 clathrin coat assembly 4/1165 18/18722 0.0226294601318747 0.104285024400831 NSG1/CLTA/CLTC/PIK3C2A 4 GO:0071800 podosome assembly 4/1165 18/18722 0.0226294601318747 0.104285024400831 LCP1/RHOA/MSN/HCK 4 GO:0150079 negative regulation of neuroinflammatory response 4/1165 18/18722 0.0226294601318747 0.104285024400831 PTPRC/TREM2/TNFRSF1B/GRN 4 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/1165 18/18722 0.0226294601318747 0.104285024400831 ZFP36/DHX36/PABPC1/ZFP36L1 4 GO:1902683 regulation of receptor localization to synapse 4/1165 18/18722 0.0226294601318747 0.104285024400831 DAG1/TYROBP/PRKCZ/HRAS 4 GO:0030879 mammary gland development 15/1165 137/18722 0.0234484232386076 0.107970467299675 LRP5/GATA3/GLI3/TBX3/PRLR/IRF6/CDO1/CEBPB/GPX1/VEGFA/CCND1/SLC29A1/OAS2/NME1/JAK2 15 GO:0044270 cellular nitrogen compound catabolic process 39/1165 451/18722 0.023622906672224 0.108684733730486 TYMP/LIN28B/QPRT/APOBEC3A/KCNQ1OT1/HINT1/NUDT4/RNASET2/NPM1/SLIRP/ZFP36/VCP/IL4I1/VIM/UPP1/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/SLCO2B1/PABPC1/KYNU/OAS2/YBX1/SND1/NUDT5/DNPH1/APEX1/ZFP36L1/PNRC2/MGAT1/CIRBP/PNP/DUT/TNFRSF1B 39 GO:0046031 ADP metabolic process 11/1165 90/18722 0.0237071253953918 0.108729659718079 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/AK3/PGK1/PKM/ENO1/BAD 11 GO:0002719 negative regulation of cytokine production involved in immune response 5/1165 27/18722 0.0237488977043229 0.108729659718079 HLA-F/TGFB1/LILRB4/LILRB1/BST2 5 GO:0007263 nitric oxide mediated signal transduction 5/1165 27/18722 0.0237488977043229 0.108729659718079 EGFR/APOE/VEGFA/ATP2B4/FPR1 5 GO:0008053 mitochondrial fusion 5/1165 27/18722 0.0237488977043229 0.108729659718079 TFRC/AFG3L2/STOML2/FIS1/BNIP3 5 GO:0018126 protein hydroxylation 5/1165 27/18722 0.0237488977043229 0.108729659718079 PRDX4/P4HB/ASPH/ERO1A/P4HA1 5 GO:0036037 CD8-positive, alpha-beta T cell activation 5/1165 27/18722 0.0237488977043229 0.108729659718079 HLA-A/HLA-E/IRF1/LILRB4/LILRB1 5 GO:0006611 protein export from nucleus 8/1165 57/18722 0.0240432745680187 0.109987693684017 PTPN14/RAN/TGFB1/MDM2/PARK7/CALR/YWHAE/NUP214 8 GO:0051494 negative regulation of cytoskeleton organization 17/1165 162/18722 0.0241257267072161 0.110185275840199 KANK1/MET/TACSTD2/TMSB4X/KANK4/TJP1/SCIN/TMSB10/LIMA1/NPM1/EPS8/GMFG/CIB1/WASF2/TRIOBP/STMN1/ADD3 17 GO:0060759 regulation of response to cytokine stimulus 17/1165 162/18722 0.0241257267072161 0.110185275840199 CXCR4/ISG15/LAPTM5/HSP90AB1/CD24/PTPRC/GSTP1/KLF4/CD74/PYCARD/PTPN6/TREM2/IRF7/OAS1/TLR2/PARP9/SYK 17 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 10/1165 79/18722 0.0243060211245195 0.110918452497502 ERBB3/FLT1/IGF1R/NCF1/PTPN6/TREM2/HCST/MYDGF/FGR/JAK2 10 GO:0001818 negative regulation of cytokine production 32/1165 357/18722 0.0243599282538315 0.110983991305809 SRGN/LGR4/TYROBP/GATA3/TMSB4X/LAPTM5/HSP90AB1/CD24/KLF2/PDCD4/ZFP36/HLA-F/ATP2B1/GBP1/HLA-DRB1/PTPRC/C1QBP/GSTP1/KLF4/PYCARD/SLC11A1/PTPN6/TGFB1/TREM2/CHID1/LILRB4/OAS1/LILRB1/BST2/TSPO/CD2AP/CD83 32 GO:1904062 regulation of cation transmembrane transport 32/1165 357/18722 0.0243599282538315 0.110983991305809 FXYD3/CTSS/APP/TMSB4X/ANK3/CYBA/TSPAN13/KCNN4/IFNGR2/SLC9A1/KCNG1/ITGB1/DLG1/FXYD5/FLNA/C4orf3/ATP2B4/AKAP9/PTPN6/GSTO1/TREM2/PARK7/GLRX/VMP1/CXCL10/YWHAE/ISCU/SLC8A1/UTRN/VDAC1/NDUFA4/LYN 32 GO:0032677 regulation of interleukin-8 production 12/1165 102/18722 0.0244839847851408 0.111232554978737 TMSB4X/FCN1/CD14/PTPRC/KLF4/CD74/PYCARD/PARK7/TLR2/LAMTOR5/SYK/LILRA2 12 GO:0046686 response to cadmium ion 9/1165 68/18722 0.0244937534212933 0.111232554978737 EGFR/B2M/SOD2/SOD1/CYBB/NCF1/FOS/CYB5A/JUN 9 GO:0060411 cardiac septum morphogenesis 9/1165 68/18722 0.0244937534212933 0.111232554978737 LRP2/TGFBR3/BMP7/ISL1/NRP2/TBX3/NRP1/SOX4/MDM2 9 GO:1901607 alpha-amino acid biosynthetic process 9/1165 68/18722 0.0244937534212933 0.111232554978737 ASS1/ADI1/ASNSD1/MTR/ATP2B4/PARK7/AASDHPPT/GLUL/CLN3 9 GO:0061008 hepaticobiliary system development 16/1165 150/18722 0.0245544008417025 0.111417826939755 EGFR/MET/TGFBR3/KRT18/LSR/GLI3/ASS1/ARID5B/PTN/CEBPB/CCND1/HRAS/RPS16/TYMS/ACO2/SULF2 16 GO:0055076 transition metal ion homeostasis 15/1165 138/18722 0.0248524915674973 0.112614471383133 FTH1/B2M/SLC40A1/APP/SLC39A10/TFRC/SOD1/EPAS1/SLC25A37/S100A8/EIF2AK1/SLC11A1/SLC39A7/ISCU/SCO2 15 GO:0046660 female sex differentiation 13/1165 114/18722 0.0248783083048432 0.112614471383133 LRP2/NR2F2/ADAMTS1/SOD1/ARID5B/TBX3/IDH1/CEBPB/HSPA5/VEGFA/UBB/RETN/LHFPL2 13 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/1165 114/18722 0.0248783083048432 0.112614471383133 TGFBR3/BMP7/FERMT1/CDKN1C/PARP1/HSP90AB1/GPC3/RBPMS/DAB2/TGFB1/GDF15/ZEB2/JAK2 13 GO:0007595 lactation 7/1165 47/18722 0.0251906506156946 0.113753114968539 PRLR/CDO1/VEGFA/CCND1/SLC29A1/OAS2/NME1 7 GO:0014911 positive regulation of smooth muscle cell migration 7/1165 47/18722 0.0251906506156946 0.113753114968539 SEMA6D/ADAMTS1/NRP1/AIF1/FOXO4/MDM2/LRP1 7 GO:0072583 clathrin-dependent endocytosis 7/1165 47/18722 0.0251906506156946 0.113753114968539 AAK1/FNBP1L/DAB2/CLTA/CLTC/AP2A2/WASL 7 GO:0019439 aromatic compound catabolic process 40/1165 467/18722 0.0253208443171709 0.11424911507418 TYMP/LIN28B/PON2/APOBEC3A/KCNQ1OT1/HINT1/NUDT4/RNASET2/NPM1/COMT/SLIRP/ZFP36/VCP/IL4I1/VIM/UPP1/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/SLCO2B1/PABPC1/KYNU/OAS2/YBX1/SND1/NUDT5/DNPH1/APEX1/ZFP36L1/PNRC2/MGAT1/CIRBP/PNP/DUT/TNFRSF1B 40 GO:0003161 cardiac conduction system development 6/1165 37/18722 0.0253990475337682 0.114261272348384 GJA5/DSG2/GJA1/ISL1/MSX2/TBX3 6 GO:0042401 cellular biogenic amine biosynthetic process 6/1165 37/18722 0.0253990475337682 0.114261272348384 GATA3/SMS/OAZ1/SRM/PARK7/GCH1 6 GO:0062237 protein localization to postsynapse 6/1165 37/18722 0.0253990475337682 0.114261272348384 DAG1/NSG1/PRKCZ/DLG1/HRAS/RAB11A 6 GO:0050808 synapse organization 37/1165 426/18722 0.0254049648834462 0.114261272348384 CDH1/MYH10/SRGN/DAG1/DLG5/APP/NRP2/ANK3/OBSL1/IGF1R/EFNA1/NRP1/PPFIBP1/APOE/PTN/C1QA/TUBB/DLG1/LGMN/C1QB/VCP/C1QC/RHOA/FLNA/DHX36/AFG3L2/WASF2/TREM2/LILRB2/ARF4/WASL/TLR2/DOCK10/ACTB/CLN3/ABI3/HSPA8 37 GO:0072331 signal transduction by p53 class mediator 17/1165 163/18722 0.025433920318164 0.114299915729267 CD44/PERP/RPL23/PHLDA3/HINT1/NPM1/PMAIP1/UBB/SOX4/CD74/PYCARD/RPL5/SMYD2/MDM2/RPL37/RPS7/IFI16 17 GO:1901361 organic cyclic compound catabolic process 42/1165 495/18722 0.0256428441479735 0.11514662736206 TYMP/LIN28B/QPRT/APOBEC3A/KCNQ1OT1/HINT1/NUDT4/RNASET2/NPM1/APOE/COMT/SLIRP/ZFP36/VCP/IL4I1/VIM/UPP1/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/SLCO2B1/PABPC1/HSD17B11/KYNU/OAS2/YBX1/SND1/NUDT5/DNPH1/APEX1/ZFP36L1/PNRC2/MGAT1/CIRBP/PNP/DUT/TNFRSF1B 42 GO:0071333 cellular response to glucose stimulus 16/1165 151/18722 0.0259397186536057 0.116386603359464 LRP5/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/SLC29A1/TREM2/CCDC186/BAD/NME1/FIS1/LRP1 16 GO:0009135 purine nucleoside diphosphate metabolic process 12/1165 103/18722 0.0262031712452384 0.117287400478089 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/DLG1/AK3/PGK1/PKM/ENO1/BAD 12 GO:0009179 purine ribonucleoside diphosphate metabolic process 12/1165 103/18722 0.0262031712452384 0.117287400478089 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/DLG1/AK3/PGK1/PKM/ENO1/BAD 12 GO:0032637 interleukin-8 production 12/1165 103/18722 0.0262031712452384 0.117287400478089 TMSB4X/FCN1/CD14/PTPRC/KLF4/CD74/PYCARD/PARK7/TLR2/LAMTOR5/SYK/LILRA2 12 GO:0001570 vasculogenesis 10/1165 80/18722 0.0262868167751842 0.117380988511622 TGFBR3/AMOT/RASA1/YAP1/ITGB8/VEGFA/JUNB/TGFB1/RRAS/ZFP36L1 10 GO:0048145 regulation of fibroblast proliferation 10/1165 80/18722 0.0262868167751842 0.117380988511622 FTH1/CDK6/PAWR/S100A6/PRKDC/GSTP1/IFI30/CD74/CD300A/CCNB1 10 GO:0120193 tight junction organization 10/1165 80/18722 0.0262868167751842 0.117380988511622 SVEP1/CLDN4/LSR/GJA1/TJP1/MARVELD3/MPP7/CLDN7/DLG1/PECAM1 10 GO:0009161 ribonucleoside monophosphate metabolic process 8/1165 58/18722 0.0264229852859013 0.117801601596318 DLG1/UPP1/PAICS/ATIC/AK3/ADK/IMPDH2/PNP 8 GO:0043666 regulation of phosphoprotein phosphatase activity 8/1165 58/18722 0.0264229852859013 0.117801601596318 SLC39A10/HSP90B1/HSP90AB1/PTPRC/LGALS3/GNAI2/CD300A/JAK2 8 GO:0030278 regulation of ossification 13/1165 115/18722 0.0265127276345189 0.118014226972684 FBN2/SRGN/PBX1/BMP7/ISG15/TFAP2A/NOTUM/PTN/ATP2B1/ESRRA/TGFB1/SLC8A1/ATRAID 13 GO:0043279 response to alkaloid 13/1165 115/18722 0.0265127276345189 0.118014226972684 CXCR4/HSPD1/HSP90AB1/AIF1/HSPA5/TGM2/DNMT3A/SLC1A3/MDM2/DHX15/HDAC2/SLC8A1/PEA15 13 GO:0032388 positive regulation of intracellular transport 20/1165 202/18722 0.026997327941335 0.118823707223216 CDH1/TCAF1/ANK3/GLI3/HSP90AB1/OAZ1/DAB2/FLNA/RAN/CIB1/MSN/TGFB1/MDM2/NMT1/HRAS/PCM1/YWHAE/FIS1/SORL1/JAK2 20 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 3/1165 11/18722 0.0272058439680378 0.118823707223216 CD55/CD46/PTPN6 3 GO:0003093 regulation of glomerular filtration 3/1165 11/18722 0.0272058439680378 0.118823707223216 GJA5/GJA1/CYBA 3 GO:0003174 mitral valve development 3/1165 11/18722 0.0272058439680378 0.118823707223216 GJA5/EFNA1/SOX4 3 GO:0010918 positive regulation of mitochondrial membrane potential 3/1165 11/18722 0.0272058439680378 0.118823707223216 VCP/STOML2/BAD 3 GO:0019372 lipoxygenase pathway 3/1165 11/18722 0.0272058439680378 0.118823707223216 GPX1/HPGD/GPX4 3 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 3/1165 11/18722 0.0272058439680378 0.118823707223216 PARP1/YAP1/SKP2 3 GO:0033860 regulation of NAD(P)H oxidase activity 3/1165 11/18722 0.0272058439680378 0.118823707223216 CYBA/PARK7/GNAI2 3 GO:0035457 cellular response to interferon-alpha 3/1165 11/18722 0.0272058439680378 0.118823707223216 GATA3/IFIT3/IFIT2 3 GO:0045060 negative thymic T cell selection 3/1165 11/18722 0.0272058439680378 0.118823707223216 GLI3/PTPRC/CD74 3 GO:0046598 positive regulation of viral entry into host cell 3/1165 11/18722 0.0272058439680378 0.118823707223216 P4HB/HLA-DRB1/CD74 3 GO:0051561 positive regulation of mitochondrial calcium ion concentration 3/1165 11/18722 0.0272058439680378 0.118823707223216 TGM2/FIS1/BNIP3 3 GO:0061635 regulation of protein complex stability 3/1165 11/18722 0.0272058439680378 0.118823707223216 SCOC/TAPBP/HSPA8 3 GO:0070417 cellular response to cold 3/1165 11/18722 0.0272058439680378 0.118823707223216 SLC9A1/NFKBIA/EIF2AK4 3 GO:0071492 cellular response to UV-A 3/1165 11/18722 0.0272058439680378 0.118823707223216 MME/TIMP1/OPN3 3 GO:0071679 commissural neuron axon guidance 3/1165 11/18722 0.0272058439680378 0.118823707223216 DAG1/NRP1/VEGFA 3 GO:0075294 positive regulation by symbiont of entry into host 3/1165 11/18722 0.0272058439680378 0.118823707223216 P4HB/HLA-DRB1/CD74 3 GO:1904181 positive regulation of membrane depolarization 3/1165 11/18722 0.0272058439680378 0.118823707223216 ANK3/PARP1/TSPO 3 GO:2000644 regulation of receptor catabolic process 3/1165 11/18722 0.0272058439680378 0.118823707223216 LAPTM5/APOE/MYLIP 3 GO:0002281 macrophage activation involved in immune response 4/1165 19/18722 0.0272873256031936 0.118823707223216 TYROBP/TREM2/SYK/GRN 4 GO:0002523 leukocyte migration involved in inflammatory response 4/1165 19/18722 0.0272873256031936 0.118823707223216 JAM3/PTN/S100A8/ADAM8 4 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 4/1165 19/18722 0.0272873256031936 0.118823707223216 PAICS/ATIC/ADK/IMPDH2 4 GO:0015802 basic amino acid transport 4/1165 19/18722 0.0272873256031936 0.118823707223216 SLC38A9/SLC11A1/CLN3/SLC7A7 4 GO:0030011 maintenance of cell polarity 4/1165 19/18722 0.0272873256031936 0.118823707223216 DLG5/PDLIM1/SLC9A1/DST 4 GO:0033194 response to hydroperoxide 4/1165 19/18722 0.0272873256031936 0.118823707223216 AIF1/GPX1/GPX3/JAK2 4 GO:0045780 positive regulation of bone resorption 4/1165 19/18722 0.0272873256031936 0.118823707223216 EGFR/TFRC/SYK/ADAM8 4 GO:1900221 regulation of amyloid-beta clearance 4/1165 19/18722 0.0272873256031936 0.118823707223216 APOE/LRPAP1/TREM2/LRP1 4 GO:1901739 regulation of myoblast fusion 4/1165 19/18722 0.0272873256031936 0.118823707223216 GDF15/PLEKHO1/CD53/CXCL10 4 GO:0060047 heart contraction 23/1165 241/18722 0.0274072611813257 0.119083851359186 GJA5/DSP/DSG2/ADRB1/GJA1/ISL1/CXCR4/DSC2/SOD1/EPAS1/SLC9A1/ATP2B1/DLG1/GPX1/FLNA/ATP2B4/AKAP9/MDM2/GSTO1/YWHAE/GCH1/SLC8A1/JAK2 23 GO:0000470 maturation of LSU-rRNA 5/1165 28/18722 0.0274743608605284 0.119083851359186 MRPL1/SNU13/RPL35/NHP2/RPL10A 5 GO:0001945 lymph vessel development 5/1165 28/18722 0.0274743608605284 0.119083851359186 SVEP1/NR2F2/PTPN14/VEGFA/SYK 5 GO:0002507 tolerance induction 5/1165 28/18722 0.0274743608605284 0.119083851359186 HLA-B/HLA-E/LILRB2/LILRB4/LYN 5 GO:0051894 positive regulation of focal adhesion assembly 5/1165 28/18722 0.0274743608605284 0.119083851359186 FERMT2/S100A10/NRP1/VEGFA/LIMS1 5 GO:1903672 positive regulation of sprouting angiogenesis 5/1165 28/18722 0.0274743608605284 0.119083851359186 TJP1/VEGFA/KLF4/PKM/JAK1 5 GO:0009755 hormone-mediated signaling pathway 19/1165 190/18722 0.0279318671983784 0.120973434092977 LGR5/BMP7/LGR4/ISL1/PARP1/ESRRG/PRLR/YAP1/SKP2/DAB2/RHOA/LATS2/ESRRA/PARK7/CALR/PHB/UFL1/PGRMC2/JAK2 19 GO:0090199 regulation of release of cytochrome c from mitochondria 7/1165 48/18722 0.0279626215722942 0.121013257428903 PMAIP1/GPX1/PLAUR/TNFSF10/PYCARD/BAD/BNIP3 7 GO:0032612 interleukin-1 production 14/1165 128/18722 0.0281467388094933 0.121622513423931 ISL1/TYROBP/APP/S100A13/GSTP1/PYCARD/GBP5/TREM2/LILRB4/HDAC2/MNDA/IFI16/JAK2/LILRA2 14 GO:0032652 regulation of interleukin-1 production 14/1165 128/18722 0.0281467388094933 0.121622513423931 ISL1/TYROBP/APP/S100A13/GSTP1/PYCARD/GBP5/TREM2/LILRB4/HDAC2/MNDA/IFI16/JAK2/LILRA2 14 GO:0071772 response to BMP 17/1165 165/18722 0.0282094636458114 0.121677877238377 FBN1/LRP2/CRIM1/TGFBR3/BMP7/SPINT1/SPINT2/GATA3/FSTL1/GPC3/PDCD4/DLX5/HTRA1/SKIL/TGFB1/GDF15/SORL1 17 GO:0071773 cellular response to BMP stimulus 17/1165 165/18722 0.0282094636458114 0.121677877238377 FBN1/LRP2/CRIM1/TGFBR3/BMP7/SPINT1/SPINT2/GATA3/FSTL1/GPC3/PDCD4/DLX5/HTRA1/SKIL/TGFB1/GDF15/SORL1 17 GO:0007006 mitochondrial membrane organization 13/1165 116/18722 0.0282245850996557 0.121677877238377 SLC9A1/BNIP3L/HSP90AA1/PMAIP1/HEBP2/SLC25A5/AFG3L2/TIMM13/NMT1/BAD/ROMO1/BNIP3/TIMM8B 13 GO:0060541 respiratory system development 20/1165 203/18722 0.0282659324400727 0.121762608431411 LAMA5/EGFR/MME/DAG1/DLG5/GLI3/EPAS1/ASS1/GPC3/DPPA4/YAP1/KLF2/CTSH/PTN/DLX5/VEGFA/MAN1A2/HSPB11/BASP1/LIPA 20 GO:0001894 tissue homeostasis 25/1165 268/18722 0.0283506403372581 0.121881630007728 EGFR/LYZ/SLC2A1/JAM3/LSR/GJA1/LAMC1/B2M/TFRC/SOD1/EPAS1/TJP1/YAP1/SNX10/CTSH/PRDX1/ITGB1/AKR1B1/PECAM1/VEGFA/OAS1/LIPA/ACTB/SYK/ADAM8 25 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 10/1165 81/18722 0.0283804187457867 0.121881630007728 FBN1/FBN2/TGFBR3/PEG10/LTBP1/HSPA5/HTRA1/SKIL/EID2/SNX6 10 GO:0048144 fibroblast proliferation 10/1165 81/18722 0.0283804187457867 0.121881630007728 FTH1/CDK6/PAWR/S100A6/PRKDC/GSTP1/IFI30/CD74/CD300A/CCNB1 10 GO:0048708 astrocyte differentiation 10/1165 81/18722 0.0283804187457867 0.121881630007728 EGFR/APP/CDK6/C1QA/S100A8/VIM/IL6ST/TREM2/LRP1/GRN 10 GO:0051924 regulation of calcium ion transport 24/1165 255/18722 0.0284964383048398 0.122286321257696 GJA1/CXCR4/CYBA/TSPAN13/SLC9A1/ATP2B1/RHOA/C4orf3/LGALS3/CAMK2G/PTPN6/GSTO1/LILRB2/VMP1/LILRB1/GNAI2/CXCL10/YWHAE/CCL4/TSPO/SLC8A1/VDAC1/LILRA2/LYN 24 GO:0002790 peptide secretion 23/1165 242/18722 0.0285733932432126 0.122468197492155 EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/SYT7/MPC2/S100A8/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/CD74/PARK7/UQCC2/CCDC186/BAD/GLUL/LRP1/JAK2/ENSA 23 GO:0009309 amine biosynthetic process 6/1165 38/18722 0.0286260956903095 0.122468197492155 GATA3/SMS/OAZ1/SRM/PARK7/GCH1 6 GO:0046633 alpha-beta T cell proliferation 6/1165 38/18722 0.0286260956903095 0.122468197492155 HLA-A/HLA-E/PTPRC/CD55/IRF1/SYK 6 GO:0048713 regulation of oligodendrocyte differentiation 6/1165 38/18722 0.0286260956903095 0.122468197492155 DAG1/CXCR4/PTN/HDAC2/TLR2/TNFRSF1B 6 GO:0071331 cellular response to hexose stimulus 16/1165 153/18722 0.0288845420064653 0.123479767160921 LRP5/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/SLC29A1/TREM2/CCDC186/BAD/NME1/FIS1/LRP1 16 GO:0002820 negative regulation of adaptive immune response 8/1165 59/18722 0.0289615543894731 0.123526751358748 HLA-F/PTPRC/IL4I1/CD55/CD46/PTPN6/LILRB4/LILRB1 8 GO:0035306 positive regulation of dephosphorylation 8/1165 59/18722 0.0289615543894731 0.123526751358748 SLC39A10/HSP90AB1/PTPRC/TGFB1/LILRB2/PPIA/CD300A/JAK2 8 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 8/1165 59/18722 0.0289615543894731 0.123526751358748 PRKCZ/PTPRC/PTPN6/VPS25/LILRB4/SNX6/SOCS3/CD300A 8 GO:0060537 muscle tissue development 35/1165 403/18722 0.0290921758226837 0.1239896605108 LRP2/NR2F2/TGFBR3/GJA5/DSP/BMP7/DSG2/GJA1/ISL1/GPC1/OBSL1/MSX2/CSRP2/TBX3/YAP1/SLC9A1/KLF5/VAMP5/ITGB1/DLG1/GPX1/FOS/RHOA/VEGFA/TGFB1/GPCPD1/UQCC2/CENPF/CALR/IGF2/SLC8A1/PRMT1/NDUFV2/CCNB1/NR4A1 35 GO:0090398 cellular senescence 11/1165 93/18722 0.0294008740427046 0.125115319182487 B2M/CDK6/PAWR/TBX3/PRKDC/SPI1/HRAS/CALR/YBX1/ABI3/YPEL3 11 GO:1901796 regulation of signal transduction by p53 class mediator 11/1165 93/18722 0.0294008740427046 0.125115319182487 CD44/RPL23/NPM1/PMAIP1/UBB/CD74/RPL5/SMYD2/MDM2/RPL37/RPS7 11 GO:0007498 mesoderm development 14/1165 129/18722 0.0298373688990113 0.126866479242151 ITGB4/BMP7/WLS/GJA1/MEST/TBX3/YAP1/ITGB1/VEGFA/KLF4/SECTM1/HCK/ZFP36L1/JAK2 14 GO:0010975 regulation of neuron projection development 38/1165 445/18722 0.0298664888939916 0.126866479242151 TENM3/SEMA6A/SEMA6D/KANK1/BMP7/ITGA6/B2M/SERPINF1/GATA3/OBSL1/EFNA1/NRP1/ITM2C/APOE/PTN/ID1/GOLGA4/HSPA5/RHOA/VEGFA/FLNA/VIM/SKIL/DHX36/CAMK2G/MYLIP/KLF4/CIB1/MDM2/HDAC2/NME1/CREB3L2/ABI3/RAB11A/SNX3/LRP1/GRN/LYN 38 GO:0032231 regulation of actin filament bundle assembly 12/1165 105/18722 0.0299027885332916 0.126866479242151 MET/TACSTD2/TJP1/FERMT2/S100A10/NRP1/SLC9A1/ID1/RHOA/FLNA/WASF2/STMN1 12 GO:0062207 regulation of pattern recognition receptor signaling pathway 12/1165 105/18722 0.0299027885332916 0.126866479242151 LGR4/CYBA/C1QBP/IRF1/TREM2/IRF7/RSAD2/OASL/TLR2/CD300A/LILRA2/LYN 12 GO:0072676 lymphocyte migration 13/1165 117/18722 0.0300157443735425 0.12715348918392 APP/GATA3/AIF1/RHOA/CCL3L3/PYCARD/MSN/MYO1G/WASL/CXCL10/CXCL16/CCL4/ADAM8 13 GO:1903828 negative regulation of cellular protein localization 13/1165 117/18722 0.0300157443735425 0.12715348918392 MAGED1/FERMT1/LMAN1/TRIM29/GBP1/DAB2/LATS2/SPI1/CLTC/TGFB1/PARK7/LILRB4/ABI3 13 GO:0050890 cognition 27/1165 296/18722 0.0300465698214144 0.127188081755354 EGFR/MME/SLC6A4/TUSC3/B2M/SERPINF1/APP/PRKCZ/HLA-DRA/APOE/COMT/ITGB1/PTN/CEBPB/LGMN/FOS/EIF2AK4/ARL6IP5/ST3GAL4/TREM2/LILRB2/ARF4/C12orf57/TLR2/CLN3/JUN/VDAC1 27 GO:0071326 cellular response to monosaccharide stimulus 16/1165 154/18722 0.0304466330893308 0.128784439736559 LRP5/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/SLC29A1/TREM2/CCDC186/BAD/NME1/FIS1/LRP1 16 GO:0046364 monosaccharide biosynthetic process 10/1165 82/18722 0.0305897859774372 0.129292521604936 SLC35B4/DDB1/FBP1/AKR1B1/TPI1/PGP/PGK1/SLC25A13/SLC25A1/FAM3C 10 GO:0009066 aspartate family amino acid metabolic process 7/1165 49/18722 0.0309341384728463 0.130453282680756 ASS1/SMS/ADI1/ASNSD1/MTR/SLC25A13/AASDHPPT 7 GO:0014075 response to amine 7/1165 49/18722 0.0309341384728463 0.130453282680756 GLDC/SOD1/ASS1/HDAC2/RGS10/NME1/NR4A1 7 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 7/1165 49/18722 0.0309341384728463 0.130453282680756 TIMP3/PMAIP1/GPX1/LGALS3/SKIL/PARK7/PEA15 7 GO:0033555 multicellular organismal response to stress 9/1165 71/18722 0.0314230116842474 0.132161157001174 VWA1/DPP4/ADRB1/GJA1/APOE/COMT/GCH1/TSPO/VDAC1 9 GO:0150116 regulation of cell-substrate junction organization 9/1165 71/18722 0.0314230116842474 0.132161157001174 FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/LIMS1/PTPRA/LRP1 9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 11/1165 94/18722 0.0314994229519614 0.132161157001174 EGFR/NR2F2/CDKN1C/CCND3/CCNE1/LATS2/CCND1/CKS2/CKS1B/ACTB/CCNB1 11 GO:0002690 positive regulation of leukocyte chemotaxis 11/1165 94/18722 0.0314994229519614 0.132161157001174 AIF1/PTN/LGMN/VEGFA/C1QBP/SPI1/CD74/GPSM3/CALR/CXCL10/CCL4 11 GO:0010389 regulation of G2/M transition of mitotic cell cycle 11/1165 94/18722 0.0314994229519614 0.132161157001174 PBX1/APP/BRD4/FOXO4/CCND1/CENPF/USP47/RAD21/BABAM1/RAB11A/CCNB1 11 GO:0009310 amine catabolic process 5/1165 29/18722 0.0315510333834978 0.132161157001174 ALDH7A1/COMT/IL4I1/ATP2B4/KYNU 5 GO:0048679 regulation of axon regeneration 5/1165 29/18722 0.0315510333834978 0.132161157001174 PTN/FLNA/KLF4/LRP1/GRN 5 GO:0090025 regulation of monocyte chemotaxis 5/1165 29/18722 0.0315510333834978 0.132161157001174 AIF1/DUSP1/LGMN/CXCL10/LYN 5 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 5/1165 29/18722 0.0315510333834978 0.132161157001174 CD44/UBB/CD74/MDM2/RPS7 5 GO:0002712 regulation of B cell mediated immunity 8/1165 60/18722 0.0316632917357862 0.132236649191196 TFRC/HLA-E/PTPRC/CD55/CD46/PTPN6/TGFB1/TREM2 8 GO:0002889 regulation of immunoglobulin mediated immune response 8/1165 60/18722 0.0316632917357862 0.132236649191196 TFRC/HLA-E/PTPRC/CD55/CD46/PTPN6/TGFB1/TREM2 8 GO:0042306 regulation of protein import into nucleus 8/1165 60/18722 0.0316632917357862 0.132236649191196 CDH1/FERMT1/GLI3/HSP90AB1/FLNA/RAN/TGFB1/JAK2 8 GO:1903670 regulation of sprouting angiogenesis 8/1165 60/18722 0.0316632917357862 0.132236649191196 SEMA6A/TJP1/KLF2/VEGFA/KLF4/PKM/JAK1/GLUL 8 GO:0010721 negative regulation of cell development 18/1165 180/18722 0.0317534693866483 0.132387196835952 FBN1/SEMA6A/SEMA6D/KANK1/FBLN1/BMP7/B2M/TACSTD2/NRP1/PTN/ID1/GBP1/VEGFA/TREM2/PCM1/LILRB1/TSPO/SORL1 18 GO:0002793 positive regulation of peptide secretion 12/1165 106/18722 0.0318874704264715 0.132387196835952 EGFR/GJA1/ISL1/MPC2/S100A8/HLA-DRB1/SOX4/SERP1/BAD/GLUL/LRP1/JAK2 12 GO:0006090 pyruvate metabolic process 12/1165 106/18722 0.0318874704264715 0.132387196835952 LDHA/APP/ALDOA/GAPDH/FBP1/MPC2/TPI1/PGK1/DLD/PKM/ENO1/VDAC1 12 GO:0006766 vitamin metabolic process 12/1165 106/18722 0.0318874704264715 0.132387196835952 LRP2/SLC2A1/SLC19A3/FOLR1/SLC19A1/SLC52A1/LGMN/MTR/SLC2A3/GSTO1/AASDHPPT/MMADHC 12 GO:0035821 modulation of process of other organism 12/1165 106/18722 0.0318874704264715 0.132387196835952 DAG1/APOE/PPIB/PSMC3/TAF11/EIF2AK4/NUCKS1/PHB/CCL4/HSPA8/JUN/SYK 12 GO:0046620 regulation of organ growth 12/1165 106/18722 0.0318874704264715 0.132387196835952 TGFBR3/SLC6A4/GJA1/DUSP9/SOD1/YAP1/LATS2/SERP1/BASP1/IGF2/CGA/CCNB1 12 GO:0071887 leukocyte apoptotic process 12/1165 106/18722 0.0318874704264715 0.132387196835952 CTSL/SLC39A10/GLI3/EFNA1/LGALS3/CD74/IRF7/TSC22D3/KDELR1/LILRB1/ADAM8/LYN 12 GO:0006413 translational initiation 13/1165 118/18722 0.031888026032818 0.132387196835952 RPS17/NPM1/EIF2AK1/RPS5/EIF2AK4/DDX1/EIF1/EIF3A/EIF2S2/EIF5/EIF3J/EIF5B/RPS3 13 GO:1903364 positive regulation of cellular protein catabolic process 16/1165 155/18722 0.0320702006505081 0.132726292197159 LRP2/LAPTM5/APOE/HSP90AA1/MAGEF1/VCP/DAB2/BAG2/PSMC1/PSMC3/PSMC6/MSN/MDM2/TREM2/PSMC4/LRP1 16 GO:0002701 negative regulation of production of molecular mediator of immune response 6/1165 39/18722 0.0321115811159348 0.132726292197159 HLA-F/PRKDC/TGFB1/LILRB4/LILRB1/BST2 6 GO:0034314 Arp2/3 complex-mediated actin nucleation 6/1165 39/18722 0.0321115811159348 0.132726292197159 ARPC3/GMFG/ARPC5L/WASF2/WASL/IQGAP2 6 GO:0086091 regulation of heart rate by cardiac conduction 6/1165 39/18722 0.0321115811159348 0.132726292197159 DSP/DSG2/ISL1/DSC2/AKAP9/YWHAE 6 GO:1903115 regulation of actin filament-based movement 6/1165 39/18722 0.0321115811159348 0.132726292197159 GJA5/DSP/DSG2/DSC2/DLG1/AKAP9 6 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 6/1165 39/18722 0.0321115811159348 0.132726292197159 PRKCZ/HLA-DRA/HLA-DRB1/CD55/CD86/CD83 6 GO:0034329 cell junction assembly 36/1165 420/18722 0.0322168080151775 0.132762728681878 CDH1/ITGB4/GJA5/CLDN4/ITGA6/JAM3/LSR/GJA1/DLG5/LAMC1/SORBS1/APP/TJP1/OBSL1/MARVELD3/FERMT2/MPP7/S100A10/NRP1/SLC9A1/PARD6B/CLDN7/DLG1/PECAM1/RHOA/VEGFA/CD9/TRIP6/DST/LIMS1/VMP1/PTPRA/TLR2/ACTB/ABI3/LRP1 36 GO:0008016 regulation of heart contraction 20/1165 206/18722 0.0323419721247964 0.132762728681878 GJA5/DSP/DSG2/ADRB1/GJA1/ISL1/DSC2/EPAS1/SLC9A1/ATP2B1/DLG1/FLNA/ATP2B4/AKAP9/MDM2/GSTO1/YWHAE/GCH1/SLC8A1/JAK2 20 GO:0048863 stem cell differentiation 20/1165 206/18722 0.0323419721247964 0.132762728681878 SEMA6A/LAMA5/SEMA6D/BMP7/KRT18/ISL1/TACSTD2/NRP2/FOLR1/MSI2/YAP1/NRP1/PTN/FOXO4/PRKDC/PTPRC/DHX36/A2M/UFL1/PDCD6 20 GO:0006346 DNA methylation-dependent heterochromatin assembly 4/1165 20/18722 0.0324751873294528 0.132762728681878 HELLS/DNMT1/DNMT3A/MBD2 4 GO:0006525 arginine metabolic process 4/1165 20/18722 0.0324751873294528 0.132762728681878 ASS1/ATP2B4/CLN3/SLC7A7 4 GO:0006851 mitochondrial calcium ion transmembrane transport 4/1165 20/18722 0.0324751873294528 0.132762728681878 AFG3L2/PMPCB/STOML2/VDAC1 4 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 4/1165 20/18722 0.0324751873294528 0.132762728681878 TYMP/UPP1/TYMS/DUT 4 GO:0010042 response to manganese ion 4/1165 20/18722 0.0324751873294528 0.132762728681878 SOD2/APP/HSPA5/TSPO 4 GO:0046629 gamma-delta T cell activation 4/1165 20/18722 0.0324751873294528 0.132762728681878 PTPRC/SOX4/LILRB1/SYK 4 GO:0051900 regulation of mitochondrial depolarization 4/1165 20/18722 0.0324751873294528 0.132762728681878 PARP1/GCLM/IFI6/TSPO 4 GO:0072567 chemokine (C-X-C motif) ligand 2 production 4/1165 20/18722 0.0324751873294528 0.132762728681878 KLF4/CD74/OAS1/LRP1 4 GO:0098543 detection of other organism 4/1165 20/18722 0.0324751873294528 0.132762728681878 HLA-B/HLA-A/HLA-DRB1/TLR2 4 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 4/1165 20/18722 0.0324751873294528 0.132762728681878 SOD2/GPX1/PARK7/PPIA 4 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 4/1165 20/18722 0.0324751873294528 0.132762728681878 KLF4/CD74/OAS1/LRP1 4 GO:2000757 negative regulation of peptidyl-lysine acetylation 4/1165 20/18722 0.0324751873294528 0.132762728681878 HINT2/SPI1/HDAC2/SET 4 GO:0051899 membrane depolarization 10/1165 83/18722 0.0329177626778045 0.134474091637931 GJA5/PRKCZ/ANK3/PARP1/GCLM/IFI6/PARK7/TSPO/SLC8A1/JUN 10 GO:0034655 nucleobase-containing compound catabolic process 35/1165 407/18722 0.0329471754843807 0.134496360722785 TYMP/LIN28B/APOBEC3A/KCNQ1OT1/HINT1/NUDT4/RNASET2/NPM1/SLIRP/ZFP36/VCP/VIM/UPP1/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/PABPC1/OAS2/YBX1/SND1/NUDT5/DNPH1/APEX1/ZFP36L1/PNRC2/MGAT1/CIRBP/PNP/DUT/TNFRSF1B 35 GO:0045766 positive regulation of angiogenesis 18/1165 181/18722 0.0332937515307144 0.135713745346332 ISL1/CXCR4/TJP1/CYBB/FLT1/ANXA3/NRP1/ITGB8/CTSH/ITGB1/VEGFA/KLF4/PKM/MYDGF/JAK1/RRAS/PDCD6/GRN 18 GO:1904018 positive regulation of vasculature development 18/1165 181/18722 0.0332937515307144 0.135713745346332 ISL1/CXCR4/TJP1/CYBB/FLT1/ANXA3/NRP1/ITGB8/CTSH/ITGB1/VEGFA/KLF4/PKM/MYDGF/JAK1/RRAS/PDCD6/GRN 18 GO:0045927 positive regulation of growth 24/1165 259/18722 0.0333838205005455 0.135982136770364 EGFR/TGFBR3/CXCR4/TFCP2L1/CYBA/YAP1/NRP1/SLC9A1/GOLGA4/S100A8/PPIB/PRKDC/RHOA/VEGFA/SERP1/CIB1/BASP1/USP47/IGF2/CXCL16/DNPH1/RAB11A/LRP1/CCNB1 24 GO:0000723 telomere maintenance 14/1165 131/18722 0.0334394358557249 0.136011270621872 PKIB/PARP1/HSP90AB1/HSP90AA1/PRKDC/CCNE1/CCT2/DHX36/GNL3/RAD50/RPA3/RFC1/NHP2/APEX1 14 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 14/1165 131/18722 0.0334394358557249 0.136011270621872 FBN1/LRP2/FBN2/CRIM1/TGFBR3/PEG10/LTBP1/HSPA5/HTRA1/SKIL/EID2/SNX6/LRP1/SORL1 14 GO:0006942 regulation of striated muscle contraction 11/1165 95/18722 0.0337023177890943 0.136882134406792 GJA5/DSP/DSG2/DSC2/SLC9A1/DLG1/AKAP9/GSTO1/C12orf57/SLC8A1/NR4A1 11 GO:0048709 oligodendrocyte differentiation 11/1165 95/18722 0.0337023177890943 0.136882134406792 DAG1/CXCR4/GLI3/PTN/GSTP1/CD9/HDAC2/TLR2/BNIP3/TNFRSF1B/LYN 11 GO:0035051 cardiocyte differentiation 16/1165 156/18722 0.0337564840973262 0.137002997280038 EGFR/TGFBR3/BMP7/ISL1/FOLR1/OBSL1/TBX3/SLC9A1/PDCD4/ITGB1/VEGFA/DHX36/TGFB1/CALR/SLC8A1/CCNB1 16 GO:0070227 lymphocyte apoptotic process 9/1165 72/18722 0.0340076169781865 0.137922510186822 SLC39A10/GLI3/EFNA1/LGALS3/CD74/TSC22D3/KDELR1/ADAM8/LYN 9 GO:0000387 spliceosomal snRNP assembly 7/1165 50/18722 0.0341102948273706 0.13794026287178 SNRPF/SNRPG/SNRPD1/SNRPE/SNRPD2/SNRPD3/SNRPC 7 GO:0019083 viral transcription 7/1165 50/18722 0.0341102948273706 0.13794026287178 IFITM3/ZFP36/PSMC3/TAF11/NUCKS1/CCL4/JUN 7 GO:0045058 T cell selection 7/1165 50/18722 0.0341102948273706 0.13794026287178 CTSL/GATA3/GLI3/RHOA/PTPRC/CD74/SYK 7 GO:0050873 brown fat cell differentiation 7/1165 50/18722 0.0341102948273706 0.13794026287178 BMP7/ADRB1/CEBPB/PLAC8/ARL4A/ERO1A/BNIP3 7 GO:0048880 sensory system development 33/1165 381/18722 0.0344098803339618 0.138055470834734 FBN1/TENM3/FBN2/EFEMP1/PBX1/BMP7/LRP5/ISL1/SMOC1/SERPINF1/GATA3/TFAP2A/GLI3/OBSL1/FLT1/NRP1/MYO7A/MFAP5/PTN/C1QA/ATP2B1/DLG1/VEGFA/VIM/SKIL/PFDN5/KLF4/ATP2B4/HDAC2/C12orf57/IMPDH2/SCO2/HMGN1 33 GO:0071384 cellular response to corticosteroid stimulus 8/1165 61/18722 0.0345322381518032 0.138055470834734 EGFR/ISL1/SERPINF1/ASS1/ZFP36/ATP2B1/GSTP1/ZFP36L1 8 GO:0000727 double-strand break repair via break-induced replication 3/1165 12/18722 0.0346306971201327 0.138055470834734 MCM3/MCM6/MCM7 3 GO:0002664 regulation of T cell tolerance induction 3/1165 12/18722 0.0346306971201327 0.138055470834734 HLA-B/LILRB2/LILRB4 3 GO:0009265 2'-deoxyribonucleotide biosynthetic process 3/1165 12/18722 0.0346306971201327 0.138055470834734 ADK/TYMS/DUT 3 GO:0010587 miRNA catabolic process 3/1165 12/18722 0.0346306971201327 0.138055470834734 LIN28B/KCNQ1OT1/SND1 3 GO:0021559 trigeminal nerve development 3/1165 12/18722 0.0346306971201327 0.138055470834734 ISL1/TFAP2A/NRP1 3 GO:0032736 positive regulation of interleukin-13 production 3/1165 12/18722 0.0346306971201327 0.138055470834734 GATA3/PRKCZ/HLA-E 3 GO:0034333 adherens junction assembly 3/1165 12/18722 0.0346306971201327 0.138055470834734 JAM3/DLG5/ACTB 3 GO:0043301 negative regulation of leukocyte degranulation 3/1165 12/18722 0.0346306971201327 0.138055470834734 HLA-F/SPI1/CD300A 3 GO:0043383 negative T cell selection 3/1165 12/18722 0.0346306971201327 0.138055470834734 GLI3/PTPRC/CD74 3 GO:0045039 protein insertion into mitochondrial inner membrane 3/1165 12/18722 0.0346306971201327 0.138055470834734 TIMM13/ROMO1/TIMM8B 3 GO:0046185 aldehyde catabolic process 3/1165 12/18722 0.0346306971201327 0.138055470834734 ADH5/PNKD/PARK7 3 GO:0046385 deoxyribose phosphate biosynthetic process 3/1165 12/18722 0.0346306971201327 0.138055470834734 ADK/TYMS/DUT 3 GO:0060907 positive regulation of macrophage cytokine production 3/1165 12/18722 0.0346306971201327 0.138055470834734 LAPTM5/CD74/LILRB1 3 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 3/1165 12/18722 0.0346306971201327 0.138055470834734 MET/PAWR/PARK7 3 GO:1903332 regulation of protein folding 3/1165 12/18722 0.0346306971201327 0.138055470834734 ST13/HSPA5/GRN 3 GO:2000508 regulation of dendritic cell chemotaxis 3/1165 12/18722 0.0346306971201327 0.138055470834734 C1QBP/SPI1/CALR 3 GO:2000628 regulation of miRNA metabolic process 3/1165 12/18722 0.0346306971201327 0.138055470834734 LIN28B/KCNQ1OT1/HRAS 3 GO:2001204 regulation of osteoclast development 3/1165 12/18722 0.0346306971201327 0.138055470834734 FBN1/TYROBP/LILRB1 3 GO:0045667 regulation of osteoblast differentiation 14/1165 132/18722 0.0353539690834129 0.140791036228223 FBN2/CRIM1/BMP7/LRP5/SMOC1/CDK6/GLI3/FERMT2/YAP1/CEBPB/ESRRA/IL6ST/SUCO/ATRAID 14 GO:0006835 dicarboxylic acid transport 10/1165 84/18722 0.0353670694961331 0.140791036228223 LRP2/SLC26A2/GJA1/FOLR1/SLC19A1/SLC13A3/ITGB1/ARL6IP5/SLC1A3/SLC25A13 10 GO:0010863 positive regulation of phospholipase C activity 6/1165 40/18722 0.0358616184530354 0.141848760492795 EGFR/FLT1/CD86/HRAS/PHB/S1PR4 6 GO:0071276 cellular response to cadmium ion 6/1165 40/18722 0.0358616184530354 0.141848760492795 EGFR/SOD1/CYBB/NCF1/FOS/JUN 6 GO:0071526 semaphorin-plexin signaling pathway 6/1165 40/18722 0.0358616184530354 0.141848760492795 SEMA6A/SEMA6D/MET/NRP2/NRP1/FLNA 6 GO:0032411 positive regulation of transporter activity 13/1165 120/18722 0.0358829994685036 0.141848760492795 TCAF1/CTSS/TMSB4X/ANK3/IFNGR2/SLC9A1/AKAP9/GSTO1/TREM2/PARK7/GLRX/VMP1/NDUFA4 13 GO:0009264 deoxyribonucleotide catabolic process 5/1165 30/18722 0.0359865176418008 0.141848760492795 TYMP/UPP1/DNPH1/PNP/DUT 5 GO:0043304 regulation of mast cell degranulation 5/1165 30/18722 0.0359865176418008 0.141848760492795 STXBP2/FGR/SYK/CD300A/LYN 5 GO:0045577 regulation of B cell differentiation 5/1165 30/18722 0.0359865176418008 0.141848760492795 IL4I1/PTPN6/BAD/ZFP36L1/SYK 5 GO:0048147 negative regulation of fibroblast proliferation 5/1165 30/18722 0.0359865176418008 0.141848760492795 FTH1/PAWR/GSTP1/IFI30/CD300A 5 GO:0060674 placenta blood vessel development 5/1165 30/18722 0.0359865176418008 0.141848760492795 NR2F2/SPINT1/ITGB8/JUNB/SOCS3 5 GO:0090151 establishment of protein localization to mitochondrial membrane 5/1165 30/18722 0.0359865176418008 0.141848760492795 HSP90AA1/TIMM13/NMT1/ROMO1/TIMM8B 5 GO:0090314 positive regulation of protein targeting to membrane 5/1165 30/18722 0.0359865176418008 0.141848760492795 TCAF1/ANK3/CIB1/HRAS/FIS1 5 GO:1903579 negative regulation of ATP metabolic process 5/1165 30/18722 0.0359865176418008 0.141848760492795 PARP1/FBP1/RHOA/FIS1/TSPO 5 GO:2000648 positive regulation of stem cell proliferation 5/1165 30/18722 0.0359865176418008 0.141848760492795 GJA1/FERMT2/TBX3/CCNE1/PTPRC 5 GO:0043648 dicarboxylic acid metabolic process 11/1165 96/18722 0.0360118445933071 0.141848760492795 FOLR1/SLC19A1/QPRT/ASS1/GCLM/IDH1/ATIC/DLD/MDH1/KYNU/GLUL 11 GO:1901655 cellular response to ketone 11/1165 96/18722 0.0360118445933071 0.141848760492795 EGFR/SERPINF1/ASS1/KLF2/GNAI1/AKR1B1/ATP2B1/KLF4/MSN/PARK7/FDX1 11 GO:0086003 cardiac muscle cell contraction 9/1165 73/18722 0.0367350684869636 0.144596030446933 GJA5/DSP/DSG2/GJA1/DSC2/SLC9A1/DLG1/FLNA/AKAP9 9 GO:0032873 negative regulation of stress-activated MAPK cascade 7/1165 51/18722 0.0374957238115289 0.147168509814184 MARVELD3/DUSP1/PDCD4/DLG1/GSTP1/TREM2/PPIA 7 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 7/1165 51/18722 0.0374957238115289 0.147168509814184 MARVELD3/DUSP1/PDCD4/DLG1/GSTP1/TREM2/PPIA 7 GO:0002260 lymphocyte homeostasis 8/1165 62/18722 0.0375721493967086 0.147168509814184 PMAIP1/SKIL/CD74/TNFSF13B/TSC22D3/DOCK10/GAPT/LYN 8 GO:0009116 nucleoside metabolic process 8/1165 62/18722 0.0375721493967086 0.147168509814184 TYMP/APOBEC3A/UPP1/ATIC/ADK/OARD1/DNPH1/PNP 8 GO:0045576 mast cell activation 8/1165 62/18722 0.0375721493967086 0.147168509814184 STXBP2/S100A13/PLSCR1/S100A12/FGR/SYK/CD300A/LYN 8 GO:0060135 maternal process involved in female pregnancy 8/1165 62/18722 0.0375721493967086 0.147168509814184 NR2F2/CTSV/GJA1/BSG/PTN/AKR1B1/JUNB/PRDX3 8 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 8/1165 62/18722 0.0375721493967086 0.147168509814184 DAG1/NSG1/PRKCZ/DLG1/EPS8/HRAS/YWHAE/RAB11A 8 GO:0014706 striated muscle tissue development 33/1165 384/18722 0.0377783541905974 0.147262851649927 LRP2/NR2F2/TGFBR3/GJA5/DSP/BMP7/DSG2/GJA1/ISL1/GPC1/OBSL1/MSX2/TBX3/YAP1/SLC9A1/KLF5/VAMP5/ITGB1/GPX1/FOS/RHOA/VEGFA/TGFB1/GPCPD1/UQCC2/CENPF/CALR/IGF2/SLC8A1/PRMT1/NDUFV2/CCNB1/NR4A1 33 GO:0055072 iron ion homeostasis 10/1165 85/18722 0.0379402951017463 0.147262851649927 FTH1/B2M/SLC40A1/TFRC/SOD1/EPAS1/SLC25A37/EIF2AK1/SLC11A1/ISCU 10 GO:0060021 roof of mouth development 10/1165 85/18722 0.0379402951017463 0.147262851649927 TGFBR3/FRAS1/TFAP2A/GLI3/ARID5B/TBX3/ITGB8/IRF6/DLG1/DLX5 10 GO:0016053 organic acid biosynthetic process 28/1165 316/18722 0.0379464754394087 0.147262851649927 SLC27A2/ACSS1/MGST3/HACD3/PTGES/ASS1/MGLL/DEGS1/CDO1/ADI1/GSTP1/ASNSD1/MTR/NDUFAB1/APOC1/TECR/ATP2B4/CD74/OSBPL9/SLC1A3/GPX4/PARK7/KYNU/AASDHPPT/GLUL/CLN3/SYK/ACADVL 28 GO:0001838 embryonic epithelial tube formation 13/1165 121/18722 0.0380090813992811 0.147262851649927 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/GATA3/IRX2/PRKACB/SOX4/TGFB1/RPS7/VASP 13 GO:0003206 cardiac chamber morphogenesis 13/1165 121/18722 0.0380090813992811 0.147262851649927 LRP2/TGFBR3/ADAMTS1/DSP/BMP7/ISL1/NRP2/GATA3/TBX3/NRP1/SOX4/TGFB1/MDM2 13 GO:0007350 blastoderm segmentation 4/1165 21/18722 0.038199663638392 0.147262851649927 NRP2/TBX3/NRP1/BASP1 4 GO:0009067 aspartate family amino acid biosynthetic process 4/1165 21/18722 0.038199663638392 0.147262851649927 ADI1/ASNSD1/MTR/AASDHPPT 4 GO:0009127 purine nucleoside monophosphate biosynthetic process 4/1165 21/18722 0.038199663638392 0.147262851649927 PAICS/ATIC/ADK/IMPDH2 4 GO:0032288 myelin assembly 4/1165 21/18722 0.038199663638392 0.147262851649927 ITGB4/GPC1/CD9/TLR2 4 GO:0033630 positive regulation of cell adhesion mediated by integrin 4/1165 21/18722 0.038199663638392 0.147262851649927 FERMT1/CIB1/PTPN6/SYK 4 GO:0046597 negative regulation of viral entry into host cell 4/1165 21/18722 0.038199663638392 0.147262851649927 IFITM3/FCN1/IFITM2/SNX3 4 GO:0048485 sympathetic nervous system development 4/1165 21/18722 0.038199663638392 0.147262851649927 NRP2/GATA3/NRP1/SOX4 4 GO:0051767 nitric-oxide synthase biosynthetic process 4/1165 21/18722 0.038199663638392 0.147262851649927 STAT1/GSTP1/TLR2/JAK2 4 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 4/1165 21/18722 0.038199663638392 0.147262851649927 STAT1/GSTP1/TLR2/JAK2 4 GO:0071498 cellular response to fluid shear stress 4/1165 21/18722 0.038199663638392 0.147262851649927 ASS1/KLF2/KLF4/TFPI2 4 GO:0072111 cell proliferation involved in kidney development 4/1165 21/18722 0.038199663638392 0.147262851649927 BMP7/GATA3/GPC3/STAT1 4 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 4/1165 21/18722 0.038199663638392 0.147262851649927 MAGED1/LGR4/TACSTD2/VEGFA 4 GO:0150146 cell junction disassembly 4/1165 21/18722 0.038199663638392 0.147262851649927 C1QA/C1QB/C1QC/TREM2 4 GO:1902473 regulation of protein localization to synapse 4/1165 21/18722 0.038199663638392 0.147262851649927 DAG1/PRKCZ/DLG1/HRAS 4 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 4/1165 21/18722 0.038199663638392 0.147262851649927 PAGE4/HSPD1/RHOA/PARK7 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/1165 21/18722 0.038199663638392 0.147262851649927 SPINT1/SLC6A4/SPINT2/PTN 4 GO:2000774 positive regulation of cellular senescence 4/1165 21/18722 0.038199663638392 0.147262851649927 B2M/PAWR/ABI3/YPEL3 4 GO:0032414 positive regulation of ion transmembrane transporter activity 12/1165 109/18722 0.0384052048237598 0.147948334364294 TCAF1/CTSS/TMSB4X/ANK3/IFNGR2/SLC9A1/AKAP9/GSTO1/TREM2/GLRX/VMP1/NDUFA4 12 GO:0014909 smooth muscle cell migration 11/1165 97/18722 0.0384301926782719 0.147948334364294 SEMA6D/ADAMTS1/NRP1/AIF1/FOXO4/RHOA/GSTP1/MDM2/APEX1/LRP1/SORL1 11 GO:0048638 regulation of developmental growth 29/1165 330/18722 0.0385307336523534 0.148233727204016 SEMA6A/SEMA6D/TGFBR3/SLC6A4/ADRB1/GJA1/DUSP9/CXCR4/APP/SOD1/YAP1/NRP1/APOE/GOLGA4/LGMN/PPIB/PRKDC/VEGFA/LATS2/AFG3L2/SERP1/PLAC8/BASP1/GDF15/IGF2/CGA/RAB11A/LRP1/CCNB1 29 GO:0035966 response to topologically incorrect protein 16/1165 159/18722 0.0392036353268038 0.150719181568048 SERPINH1/HSPD1/HSP90AB1/HSPE1/HSP90AA1/HSPA5/VCP/DNAJB4/CCND1/SERP1/ERO1A/UFL1/CREB3L2/HSPA8/MANF/UBXN4 16 GO:0061041 regulation of wound healing 14/1165 134/18722 0.0394174655772038 0.151437532022481 KANK1/CLDN4/FERMT1/GJA1/CXCR4/FERMT2/PLPP3/PRDX2/TNFRSF12A/APOE/ITGB1/CD9/ST3GAL4/HRAS 14 GO:0048844 artery morphogenesis 9/1165 74/18722 0.0396083308806922 0.151926509899035 LRP2/GJA5/FOLR1/NRP1/APOE/VEGFA/HPGD/SOX4/LRP1 9 GO:0120192 tight junction assembly 9/1165 74/18722 0.0396083308806922 0.151926509899035 CLDN4/LSR/GJA1/TJP1/MARVELD3/MPP7/CLDN7/DLG1/PECAM1 9 GO:0031331 positive regulation of cellular catabolic process 36/1165 427/18722 0.039625941651913 0.151926509899035 LRP2/LIN28B/APP/LAPTM5/KCNQ1OT1/BNIP3L/APOE/HSP90AA1/ZFP36/SESN1/MAGEF1/VCP/DAB2/BAG2/SCOC/SLC25A5/PSMC1/PSMC3/DHX36/PIK3C2A/PSMC6/MSN/MDM2/TREM2/PARK7/TRIM22/PABPC1/BAD/PSMC4/UFL1/BNIP3/ZFP36L1/VDAC1/ADAM8/LRP1/TNFRSF1B 36 GO:0001678 cellular glucose homeostasis 17/1165 172/18722 0.0397150416696061 0.152060388056957 LRP5/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/NUCKS1/SLC29A1/TREM2/CCDC186/BAD/NME1/FIS1/LRP1 17 GO:1901136 carbohydrate derivative catabolic process 17/1165 172/18722 0.0397150416696061 0.152060388056957 TYMP/CTSL/CD44/GPC1/APOBEC3A/HINT1/NUDT4/FUCA1/UPP1/CST3/TGFB1/FUCA2/DNPH1/MGAT1/PNP/DUT/NPL 17 GO:0032735 positive regulation of interleukin-12 production 6/1165 41/18722 0.0398814942239387 0.15217867238543 ISL1/HSPD1/LAPTM5/IRF1/TLR2/SYK 6 GO:0050691 regulation of defense response to virus by host 6/1165 41/18722 0.0398814942239387 0.15217867238543 HSP90AA1/STAT1/EIF2AK4/PYCARD/LILRB1/PARP9 6 GO:0060612 adipose tissue development 6/1165 41/18722 0.0398814942239387 0.15217867238543 LRP5/ARID5B/UBB/SPI1/PGRMC2/SORL1 6 GO:0071470 cellular response to osmotic stress 6/1165 41/18722 0.0398814942239387 0.15217867238543 SLC2A1/AKR1B1/BAD/CLN3/TSPO/ZFP36L1 6 GO:1902622 regulation of neutrophil migration 6/1165 41/18722 0.0398814942239387 0.15217867238543 DPP4/JAM3/C1QBP/CD74/RHOG/ADAM8 6 GO:0016331 morphogenesis of embryonic epithelium 15/1165 147/18722 0.0404431064337519 0.154216818215115 LRP2/LAMA5/BMP7/SPINT1/SPINT2/FOLR1/LMO4/GATA3/TFAP2A/IRX2/PRKACB/SOX4/TGFB1/RPS7/VASP 15 GO:0035023 regulation of Rho protein signal transduction 10/1165 86/18722 0.0406398881955448 0.154477851086689 ADGRG1/KANK1/MET/NRP1/NET1/APOE/ITGB1/EPS8/ARHGDIB/STMN1 10 GO:0032611 interleukin-1 beta production 12/1165 110/18722 0.0407719900377672 0.154477851086689 ISL1/TYROBP/APP/GSTP1/PYCARD/GBP5/TREM2/LILRB4/MNDA/IFI16/JAK2/LILRA2 12 GO:0032651 regulation of interleukin-1 beta production 12/1165 110/18722 0.0407719900377672 0.154477851086689 ISL1/TYROBP/APP/GSTP1/PYCARD/GBP5/TREM2/LILRB4/MNDA/IFI16/JAK2/LILRA2 12 GO:0046902 regulation of mitochondrial membrane permeability 8/1165 63/18722 0.0407864815843866 0.154477851086689 SLC9A1/BNIP3L/PMAIP1/HEBP2/SLC25A5/NMT1/BAD/BNIP3 8 GO:0001782 B cell homeostasis 5/1165 31/18722 0.0407867762890564 0.154477851086689 CD74/TNFSF13B/DOCK10/GAPT/LYN 5 GO:0002828 regulation of type 2 immune response 5/1165 31/18722 0.0407867762890564 0.154477851086689 GATA3/PRKCZ/CD86/CD74/RSAD2 5 GO:0033006 regulation of mast cell activation involved in immune response 5/1165 31/18722 0.0407867762890564 0.154477851086689 STXBP2/FGR/SYK/CD300A/LYN 5 GO:0046386 deoxyribose phosphate catabolic process 5/1165 31/18722 0.0407867762890564 0.154477851086689 TYMP/UPP1/DNPH1/PNP/DUT 5 GO:0071480 cellular response to gamma radiation 5/1165 31/18722 0.0407867762890564 0.154477851086689 CYBA/YAP1/HSPA5/MDM2/HRAS 5 GO:0090162 establishment of epithelial cell polarity 5/1165 31/18722 0.0407867762890564 0.154477851086689 FERMT1/FRMD4A/FRMD4B/RHOA/MSN 5 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 7/1165 52/18722 0.0410945787294679 0.155016041941199 PLPP3/ERGIC2/ERGIC3/ARF4/KDELR1/TAPBP/KDELR2 7 GO:0021545 cranial nerve development 7/1165 52/18722 0.0410945787294679 0.155016041941199 ISL1/NRP2/TFAP2A/GLI3/ERBB3/NRP1/SLC1A3 7 GO:0043277 apoptotic cell clearance 7/1165 52/18722 0.0410945787294679 0.155016041941199 TYROBP/FCN1/TGM2/RHOBTB1/TREM2/RHOG/LRP1 7 GO:0045010 actin nucleation 7/1165 52/18722 0.0410945787294679 0.155016041941199 SCIN/ARPC3/GMFG/ARPC5L/WASF2/WASL/IQGAP2 7 GO:1903426 regulation of reactive oxygen species biosynthetic process 7/1165 52/18722 0.0410945787294679 0.155016041941199 PAGE4/SOD2/HSPD1/CYBA/SLC5A3/RHOA/PARK7 7 GO:2000378 negative regulation of reactive oxygen species metabolic process 7/1165 52/18722 0.0410945787294679 0.155016041941199 PAGE4/TFAP2A/HSPD1/RHOA/PARK7/BNIP3/VDAC1 7 GO:0006364 rRNA processing 21/1165 225/18722 0.0415639529868838 0.156681308338065 RPS17/RPS21/MRPL1/RPS27/PRKDC/RPS28/SNU13/DDX27/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/BRIX1/RPS7/NHP2/RPS16/NOP56/IMP3/RPL10A 21 GO:0090257 regulation of muscle system process 23/1165 252/18722 0.0423986251282144 0.158741433721034 GJA5/DSP/DSG2/DAG1/PARP1/DSC2/SOD1/AIF1/SLC9A1/ATP2B1/DLG1/RHOA/CAMK2G/KLF4/ATP2B4/AKAP9/IL6ST/GSTO1/ENO1/C12orf57/SLC8A1/TNFRSF1B/NR4A1 23 GO:0071482 cellular response to light stimulus 13/1165 123/18722 0.0425264776174865 0.158741433721034 MME/TIMP1/PARP1/DDB1/NPM1/PTN/DHX36/EIF2AK4/CRIP1/MDM2/OPN3/NMT1/USP47 13 GO:0035148 tube formation 15/1165 148/18722 0.0425286416938798 0.158741433721034 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/GATA3/IRX2/TGM2/VEGFA/PRKACB/SOX4/TGFB1/RPS7/VASP 15 GO:0043484 regulation of RNA splicing 15/1165 148/18722 0.0425286416938798 0.158741433721034 ESRP1/MBNL3/MBNL2/NPM1/C1QBP/FUS/RBM39/PRDX6/SF1/NCL/SRSF2/RBM3/HSPA8/CIRBP/SON 15 GO:0006094 gluconeogenesis 9/1165 75/18722 0.0426301626382138 0.158741433721034 SLC35B4/DDB1/FBP1/TPI1/PGP/PGK1/SLC25A13/SLC25A1/FAM3C 9 GO:0033077 T cell differentiation in thymus 9/1165 75/18722 0.0426301626382138 0.158741433721034 B2M/GATA3/GLI3/SOD1/PRKDC/PTPRC/CD74/ZFP36L1/ADAM8 9 GO:0043627 response to estrogen 9/1165 75/18722 0.0426301626382138 0.158741433721034 LDHA/GATA3/HSPD1/GLI3/CD24/COMT/CCND1/MDM2/KRT19 9 GO:0048662 negative regulation of smooth muscle cell proliferation 9/1165 75/18722 0.0426301626382138 0.158741433721034 SOD2/AIF1/APOE/PDCD4/COMT/RHOA/GSTP1/KLF4/SF1 9 GO:1902369 negative regulation of RNA catabolic process 9/1165 75/18722 0.0426301626382138 0.158741433721034 SLIRP/ZFP36/DHX36/FUS/SLC11A1/LRPPRC/PABPC1/YBX1/CIRBP 9 GO:0006000 fructose metabolic process 3/1165 13/18722 0.042987168939243 0.158741433721034 ALDOA/FBP1/AKR1B1 3 GO:0007183 SMAD protein complex assembly 3/1165 13/18722 0.042987168939243 0.158741433721034 PARP1/EID2/TGFB1 3 GO:0008298 intracellular mRNA localization 3/1165 13/18722 0.042987168939243 0.158741433721034 ZFP36/DHX36/ZFP36L1 3 GO:0015809 arginine transport 3/1165 13/18722 0.042987168939243 0.158741433721034 SLC38A9/SLC11A1/CLN3 3 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 3/1165 13/18722 0.042987168939243 0.158741433721034 PARP1/YAP1/SKP2 3 GO:0034135 regulation of toll-like receptor 2 signaling pathway 3/1165 13/18722 0.042987168939243 0.158741433721034 CYBA/TREM2/LYN 3 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway 3/1165 13/18722 0.042987168939243 0.158741433721034 TREM2/LILRA2/LYN 3 GO:0034982 mitochondrial protein processing 3/1165 13/18722 0.042987168939243 0.158741433721034 AFG3L2/PMPCB/STOML2 3 GO:0035745 T-helper 2 cell cytokine production 3/1165 13/18722 0.042987168939243 0.158741433721034 GATA3/PRKCZ/RSAD2 3 GO:0036462 TRAIL-activated apoptotic signaling pathway 3/1165 13/18722 0.042987168939243 0.158741433721034 TIMP3/SPI1/PARK7 3 GO:0042492 gamma-delta T cell differentiation 3/1165 13/18722 0.042987168939243 0.158741433721034 PTPRC/SOX4/SYK 3 GO:0046689 response to mercury ion 3/1165 13/18722 0.042987168939243 0.158741433721034 BSG/PARK7/AQP9 3 GO:0048012 hepatocyte growth factor receptor signaling pathway 3/1165 13/18722 0.042987168939243 0.158741433721034 MET/NRP1/STMN1 3 GO:0051481 negative regulation of cytosolic calcium ion concentration 3/1165 13/18722 0.042987168939243 0.158741433721034 ATP2B1/SLC8A1/LRP1 3 GO:0071696 ectodermal placode development 3/1165 13/18722 0.042987168939243 0.158741433721034 TBX3/NRP1/HDAC2 3 GO:0098814 spontaneous synaptic transmission 3/1165 13/18722 0.042987168939243 0.158741433721034 NSG1/APP/ITGB1 3 GO:0110096 cellular response to aldehyde 3/1165 13/18722 0.042987168939243 0.158741433721034 ADH5/AKR1B1/PARK7 3 GO:1902947 regulation of tau-protein kinase activity 3/1165 13/18722 0.042987168939243 0.158741433721034 HSP90AB1/HSP90AA1/SORL1 3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 3/1165 13/18722 0.042987168939243 0.158741433721034 TMSB4X/ZNF593/LAMTOR5 3 GO:1903651 positive regulation of cytoplasmic transport 3/1165 13/18722 0.042987168939243 0.158741433721034 DAB2/MSN/SORL1 3 GO:1905907 negative regulation of amyloid fibril formation 3/1165 13/18722 0.042987168939243 0.158741433721034 APOE/PFDN5/TREM2 3 GO:2000551 regulation of T-helper 2 cell cytokine production 3/1165 13/18722 0.042987168939243 0.158741433721034 GATA3/PRKCZ/RSAD2 3 GO:0003205 cardiac chamber development 16/1165 161/18722 0.0431701492281519 0.159312325849847 LRP2/ADAMTS6/TGFBR3/GJA5/ADAMTS1/DSP/BMP7/ISL1/NRP2/LMO4/GATA3/TBX3/NRP1/SOX4/TGFB1/MDM2 16 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 12/1165 111/18722 0.0432388395644378 0.159356274770315 EGFR/ERBB3/FLT1/IGF1R/NCF1/KLF4/PTPN6/TREM2/HCST/MYDGF/FGR/JAK2 12 GO:0090288 negative regulation of cellular response to growth factor stimulus 12/1165 111/18722 0.0432388395644378 0.159356274770315 FBN1/LRP2/SEMA6A/CRIM1/GATA3/GPC1/HTRA1/SKIL/ATP2B4/SULF2/PDCD6/SORL1 12 GO:0150063 visual system development 32/1165 375/18722 0.0436791352985946 0.160840548790539 FBN1/TENM3/FBN2/EFEMP1/PBX1/BMP7/LRP5/SMOC1/SERPINF1/GATA3/TFAP2A/GLI3/OBSL1/FLT1/NRP1/MYO7A/MFAP5/PTN/C1QA/ATP2B1/DLG1/VEGFA/VIM/SKIL/PFDN5/KLF4/ATP2B4/HDAC2/C12orf57/IMPDH2/SCO2/HMGN1 32 GO:0002791 regulation of peptide secretion 19/1165 200/18722 0.0436988841805757 0.160840548790539 EGFR/DPP4/LRP5/GJA1/ISL1/SYT7/MPC2/S100A8/HLA-DRB1/HMGN3/SOX4/SERP1/CD74/UQCC2/BAD/GLUL/LRP1/JAK2/ENSA 19 GO:0042113 B cell activation 29/1165 334/18722 0.0439060231882803 0.161497056458596 TYROBP/HSPD1/SLC39A10/TFRC/PAWR/LAPTM5/ITGB1/PRKDC/PTPRC/SLC25A5/IL4I1/VAV3/SPI1/CD86/CD74/PTPN6/TNFSF13B/TGFB1/KLF6/PHB/BAD/MNDA/DOCK10/BST2/GAPT/ZFP36L1/SYK/CD300A/LYN 29 GO:0007520 myoblast fusion 6/1165 42/18722 0.0441756475133301 0.161546082285107 ERVW-1/CD9/GDF15/PLEKHO1/CD53/CXCL10 6 GO:0014912 negative regulation of smooth muscle cell migration 6/1165 42/18722 0.0441756475133301 0.161546082285107 SEMA6D/AIF1/RHOA/GSTP1/APEX1/LRP1 6 GO:0030890 positive regulation of B cell proliferation 6/1165 42/18722 0.0441756475133301 0.161546082285107 SLC39A10/TFRC/PTPRC/VAV3/CD74/TNFSF13B 6 GO:0032689 negative regulation of interferon-gamma production 6/1165 42/18722 0.0441756475133301 0.161546082285107 GATA3/LAPTM5/HLA-DRB1/C1QBP/LILRB4/LILRB1 6 GO:0033003 regulation of mast cell activation 6/1165 42/18722 0.0441756475133301 0.161546082285107 STXBP2/PLSCR1/FGR/SYK/CD300A/LYN 6 GO:0051602 response to electrical stimulus 6/1165 42/18722 0.0441756475133301 0.161546082285107 SOD2/AIF1/SLC9A1/CD14/AKAP9/NR4A1 6 GO:1900274 regulation of phospholipase C activity 6/1165 42/18722 0.0441756475133301 0.161546082285107 EGFR/FLT1/CD86/HRAS/PHB/S1PR4 6 GO:2000404 regulation of T cell migration 6/1165 42/18722 0.0441756475133301 0.161546082285107 APP/AIF1/RHOA/PYCARD/CXCL10/ADAM8 6 GO:0030837 negative regulation of actin filament polymerization 8/1165 64/18722 0.0441783781057614 0.161546082285107 KANK1/TMSB4X/KANK4/SCIN/TMSB10/EPS8/TRIOBP/ADD3 8 GO:0002320 lymphoid progenitor cell differentiation 4/1165 22/18722 0.0444635996240929 0.161641311327742 GATA3/PRKDC/SOX4/SPI1 4 GO:0019400 alditol metabolic process 4/1165 22/18722 0.0444635996240929 0.161641311327742 AKR1B1/TPI1/PGP/GK 4 GO:0021854 hypothalamus development 4/1165 22/18722 0.0444635996240929 0.161641311327742 NRP2/UQCRQ/NRP1/UBB 4 GO:0022616 DNA strand elongation 4/1165 22/18722 0.0444635996240929 0.161641311327742 MCM3/MCM7/RAD50/NUCKS1 4 GO:0032727 positive regulation of interferon-alpha production 4/1165 22/18722 0.0444635996240929 0.161641311327742 HSPD1/STAT1/DHX36/IRF7 4 GO:0034755 iron ion transmembrane transport 4/1165 22/18722 0.0444635996240929 0.161641311327742 SLC40A1/SLC25A37/SLC11A1/ISCU 4 GO:0035024 negative regulation of Rho protein signal transduction 4/1165 22/18722 0.0444635996240929 0.161641311327742 KANK1/MET/ITGB1/STMN1 4 GO:0045061 thymic T cell selection 4/1165 22/18722 0.0444635996240929 0.161641311327742 GATA3/GLI3/PTPRC/CD74 4 GO:0071404 cellular response to low-density lipoprotein particle stimulus 4/1165 22/18722 0.0444635996240929 0.161641311327742 FCER1G/ITGB1/CD9/SYK 4 GO:0008347 glial cell migration 7/1165 53/18722 0.0449105164821906 0.162844140190269 ADGRG1/LAMB1/GLI3/CD9/TREM2/TSPO/LRP1 7 GO:0034381 plasma lipoprotein particle clearance 7/1165 53/18722 0.0449105164821906 0.162844140190269 APOE/LRPAP1/MYLIP/APOC1/TREM2/CNPY2/LIPA 7 GO:0043620 regulation of DNA-templated transcription in response to stress 7/1165 53/18722 0.0449105164821906 0.162844140190269 EPAS1/KLF2/CEBPB/HSPA5/VEGFA/BCLAF1/JUN 7 GO:2000772 regulation of cellular senescence 7/1165 53/18722 0.0449105164821906 0.162844140190269 B2M/CDK6/PAWR/PRKDC/YBX1/ABI3/YPEL3 7 GO:0034250 positive regulation of cellular amide metabolic process 16/1165 162/18722 0.0452572092304464 0.163995297230791 EFNA1/NPM1/PRKDC/RHOA/SOX4/C1QBP/VIM/DHX36/EIF2AK4/SERP1/RPL5/PKM/UQCC2/PABPC1/RBM3/CIRBP 16 GO:0044242 cellular lipid catabolic process 20/1165 214/18722 0.04533989337894 0.164188917119994 SLC27A2/ECHDC2/MGLL/ECHS1/IDH1/PCCB/FUCA1/AIG1/ECI1/ECI2/APOC1/ETFA/GPCPD1/ECH1/PRDX6/HADHB/LRP1/SORL1/ACADVL/ECHDC1 20 GO:0051054 positive regulation of DNA metabolic process 19/1165 201/18722 0.0455703396347909 0.164917031831129 EGFR/PKIB/PARP1/TFRC/HSP90AB1/ANXA3/HSP90AA1/PRKDC/PTPRC/CCT2/DHX36/KLF4/FUS/GNL3/RAD50/TGFB1/BABAM1/RPS3/PARP9 19 GO:0043406 positive regulation of MAP kinase activity 12/1165 112/18722 0.0458074037216911 0.165668142454802 EGFR/MAGED1/CD24/FLT1/VEGFA/TGFB1/HRAS/S100A12/ERP29/RPS3/SYK/ADAM8 12 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 5/1165 32/18722 0.0459561356057729 0.165672311596149 PRKCZ/HLA-DRA/HLA-DRB1/CD86/CD83 5 GO:0050850 positive regulation of calcium-mediated signaling 5/1165 32/18722 0.0459561356057729 0.165672311596149 SLC9A1/CIB1/TREM2/CCL4/SYK 5 GO:0051497 negative regulation of stress fiber assembly 5/1165 32/18722 0.0459561356057729 0.165672311596149 MET/TACSTD2/TJP1/WASF2/STMN1 5 GO:1900745 positive regulation of p38MAPK cascade 5/1165 32/18722 0.0459561356057729 0.165672311596149 NCF1/VEGFA/SPI1/GADD45G/PRMT1 5 GO:1905476 negative regulation of protein localization to membrane 5/1165 32/18722 0.0459561356057729 0.165672311596149 GBP1/DAB2/CLTC/TGFB1/ABI3 5 GO:0000086 G2/M transition of mitotic cell cycle 14/1165 137/18722 0.0461196742311493 0.166048576946402 PBX1/APP/WEE1/BRD4/SKP2/FOXO4/CCND1/CENPF/USP47/RAD21/BABAM1/RAB11A/CCNB1/ENSA 14 GO:0007266 Rho protein signal transduction 14/1165 137/18722 0.0461196742311493 0.166048576946402 ADGRG1/KANK1/MET/HACD3/CTNNAL1/NRP1/NET1/APOE/ITGB1/RHOA/EPS8/ARHGDIB/STMN1/RHOG 14 GO:0045807 positive regulation of endocytosis 11/1165 100/18722 0.0463584821184482 0.16658781058313 B2M/GPC3/APOE/DAB2/CD14/VEGFA/TREM2/WASL/CLN3/SYK/LRP1 11 GO:0046545 development of primary female sexual characteristics 11/1165 100/18722 0.0463584821184482 0.16658781058313 NR2F2/ADAMTS1/SOD1/ARID5B/IDH1/CEBPB/HSPA5/VEGFA/UBB/RETN/LHFPL2 11 GO:0060840 artery development 11/1165 100/18722 0.0463584821184482 0.16658781058313 LRP2/ADAMTS6/GJA5/FOLR1/GLI3/NRP1/APOE/VEGFA/HPGD/SOX4/LRP1 11 GO:0046879 hormone secretion 26/1165 295/18722 0.0466366151621301 0.167480051762659 EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/GATA3/SYT7/TBX3/MPC2/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/PARK7/UQCC2/CCDC186/RETN/BAD/GLUL/CGA/LRP1/JAK2/ENSA/LYN 26 GO:0001959 regulation of cytokine-mediated signaling pathway 15/1165 150/18722 0.0469266811918463 0.168413977960251 CXCR4/ISG15/LAPTM5/HSP90AB1/CD24/PTPRC/GSTP1/CD74/PYCARD/PTPN6/TREM2/IRF7/OAS1/PARP9/SYK 15 GO:0031669 cellular response to nutrient levels 20/1165 215/18722 0.0471965186772193 0.169274159319637 CTSV/SLC2A1/FOLR1/COMT/PTN/SESN1/ATP2B1/PMAIP1/HSPA5/UPP1/EIF2AK4/STK26/MDM2/CD68/TXN2/GLUL/IFI16/HSPA8/JUN/GABARAPL1 20 GO:0007611 learning or memory 23/1165 255/18722 0.0473717482211597 0.169794139696915 EGFR/MME/SLC6A4/B2M/SERPINF1/APP/PRKCZ/APOE/COMT/ITGB1/PTN/CEBPB/LGMN/FOS/EIF2AK4/ARL6IP5/TREM2/LILRB2/ARF4/TLR2/CLN3/JUN/VDAC1 23 GO:0016051 carbohydrate biosynthetic process 19/1165 202/18722 0.0474986851111608 0.170031963985297 ISYNA1/SORBS1/AGL/SLC35B4/DDB1/FBP1/AKR1B1/TPI1/FUT8/PGP/CLTC/PGK1/TGFB1/ST3GAL4/SLC25A13/IGF2/SLC25A1/FAM3C/UGP2 19 GO:0090087 regulation of peptide transport 19/1165 202/18722 0.0474986851111608 0.170031963985297 EGFR/DPP4/LRP5/GJA1/ISL1/SYT7/MPC2/S100A8/HLA-DRB1/HMGN3/SOX4/SERP1/CD74/UQCC2/BAD/GLUL/LRP1/JAK2/ENSA 19 GO:0043534 blood vessel endothelial cell migration 17/1165 176/18722 0.04764280865758 0.170439187377308 EPHB4/TMSB4X/AMOT/EFNA1/NRP1/APOE/ITGB1/ID1/GPX1/RHOA/VEGFA/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1/NR4A1 17 GO:0006487 protein N-linked glycosylation 8/1165 65/18722 0.0477506580790922 0.170607539018424 TUSC3/DDOST/RPN2/FUT8/GFPT1/OSTC/TMEM165/MGAT1 8 GO:1905330 regulation of morphogenesis of an epithelium 8/1165 65/18722 0.0477506580790922 0.170607539018424 MAGED1/BMP7/LGR4/GJA1/TACSTD2/GATA3/VEGFA/CXCL10 8 GO:0032386 regulation of intracellular transport 29/1165 337/18722 0.0482880958430001 0.172417991073002 CDH1/TCAF1/FERMT1/PTPN14/ANK3/LMAN1/GLI3/HSP90AB1/BNIP3L/LCP1/OAZ1/DAB2/FLNA/MX2/RAN/CIB1/MSN/TGFB1/MDM2/NMT1/PARK7/HRAS/PCM1/YWHAE/FIS1/SNX3/SORL1/JAK2/NUP214 29 GO:0031623 receptor internalization 12/1165 113/18722 0.0484792428496141 0.172990457797129 TFRC/FCER1G/ITGB1/LRPAP1/VEGFA/CD9/GRB2/CLTC/LILRB4/LILRB1/SYK/LRP1 12 GO:0001504 neurotransmitter uptake 6/1165 43/18722 0.0487476570493336 0.173397084295253 SLC6A4/SLC38A1/ITGB1/SLC1A3/SLC29A1/PARK7 6 GO:0006509 membrane protein ectodomain proteolysis 6/1165 43/18722 0.0487476570493336 0.173397084295253 DAG1/TIMP3/TIMP1/APOE/ADAM8/TNFRSF1B 6 GO:0009268 response to pH 6/1165 43/18722 0.0487476570493336 0.173397084295253 GJA1/SERPINF1/CTSS/SLC9A1/LGMN/GNA11 6 GO:0034142 toll-like receptor 4 signaling pathway 6/1165 43/18722 0.0487476570493336 0.173397084295253 NFKBIA/CD14/TREM2/OAS1/LILRA2/LYN 6 GO:0035794 positive regulation of mitochondrial membrane permeability 6/1165 43/18722 0.0487476570493336 0.173397084295253 SLC9A1/BNIP3L/HEBP2/SLC25A5/NMT1/BNIP3 6 GO:0006584 catecholamine metabolic process 7/1165 54/18722 0.0489466840251079 0.173664815065064 GATA3/EPAS1/COMT/AKR1B1/PNKD/PARK7/GCH1 7 GO:0009712 catechol-containing compound metabolic process 7/1165 54/18722 0.0489466840251079 0.173664815065064 GATA3/EPAS1/COMT/AKR1B1/PNKD/PARK7/GCH1 7 GO:0070228 regulation of lymphocyte apoptotic process 7/1165 54/18722 0.0489466840251079 0.173664815065064 SLC39A10/EFNA1/LGALS3/CD74/TSC22D3/ADAM8/LYN 7 GO:0086002 cardiac muscle cell action potential involved in contraction 7/1165 54/18722 0.0489466840251079 0.173664815065064 GJA5/DSP/DSG2/GJA1/DSC2/DLG1/FLNA 7 GO:0034976 response to endoplasmic reticulum stress 23/1165 256/18722 0.0491197541454044 0.173983458100633 HSP90B1/P4HB/CEBPB/PMAIP1/HSPA5/VCP/PDIA4/UBE4B/EIF2AK4/PSMC6/CCND1/SERP1/USP14/PARK7/CCDC47/CALR/ERO1A/UFL1/CREB3L2/ERP29/JUN/MANF/UBXN4 23 GO:0055117 regulation of cardiac muscle contraction 9/1165 77/18722 0.0491294817547663 0.173983458100633 GJA5/DSP/DSG2/DSC2/SLC9A1/DLG1/AKAP9/GSTO1/SLC8A1 9 GO:1901983 regulation of protein acetylation 9/1165 77/18722 0.0491294817547663 0.173983458100633 ISL1/GATA3/SOX4/HINT2/SPI1/BRD7/PARK7/HDAC2/SET 9 GO:0051146 striated muscle cell differentiation 25/1165 283/18722 0.0491627843321575 0.173991619455486 ISL1/ERVW-1/KRT8/OBSL1/CSRP2/TBX3/SLC9A1/KLF5/ITGB1/GPX1/VEGFA/MORF4L2/CD9/TGFB1/BHLHE41/GDF15/KRT19/PLEKHO1/CALR/IGF2/YBX1/CD53/CXCL10/SLC8A1/CCNB1 25 GO:0048592 eye morphogenesis 15/1165 151/18722 0.0492414197070934 0.174160106374238 FBN1/TENM3/FBN2/EFEMP1/BMP7/LRP5/TFAP2A/GLI3/OBSL1/MYO7A/MFAP5/PTN/VEGFA/C12orf57/HMGN1 15 GO:0030324 lung development 17/1165 177/18722 0.0497883438384485 0.175983610809327 LAMA5/EGFR/MME/DAG1/DLG5/GLI3/EPAS1/GPC3/DPPA4/YAP1/KLF2/CTSH/PTN/VEGFA/MAN1A2/HSPB11/LIPA 17 GO:0072594 establishment of protein localization to organelle 35/1165 422/18722 0.0509620392082685 0.179202952643382 CDH1/FERMT1/HSPD1/LMAN1/GLI3/LAPTM5/HSP90AB1/RPL23/NFKBIA/BNIP3L/HSP90AA1/HSPA5/FLNA/CCT2/SRPRB/PMPCB/RAN/TIMM13/SRP14/TGFB1/VPS25/CD68/TXNIP/NMT1/ROMO1/TNPO1/FIS1/TSPO/RAB11A/TIMM8B/HSPA8/SYK/SORL1/JAK2/NUP214 35 GO:0070374 positive regulation of ERK1 and ERK2 cascade 20/1165 217/18722 0.0510723816538495 0.179202952643382 EGFR/APP/CD44/PRKCZ/FERMT2/NRP1/APOE/HLA-DRB1/PTPRC/CCL3L3/CD74/CIB1/PYCARD/TGFB1/TREM2/HRAS/PHB/GNAI2/CCL4/LRP1 20 GO:0002082 regulation of oxidative phosphorylation 4/1165 23/18722 0.0512662728905454 0.179202952643382 VCP/RHOA/UQCC2/COX7A2 4 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 4/1165 23/18722 0.0512662728905454 0.179202952643382 ENPEP/MME/CYBA/RHOA 4 GO:0003283 atrial septum development 4/1165 23/18722 0.0512662728905454 0.179202952643382 GJA5/ISL1/SOX4/MDM2 4 GO:0006929 substrate-dependent cell migration 4/1165 23/18722 0.0512662728905454 0.179202952643382 NRP1/PTPRC/CD2AP/ADAM8 4 GO:0021884 forebrain neuron development 4/1165 23/18722 0.0512662728905454 0.179202952643382 NRP2/UQCRQ/NRP1/UBB 4 GO:0035994 response to muscle stretch 4/1165 23/18722 0.0512662728905454 0.179202952643382 SLC9A1/NFKBIA/FOS/SLC8A1 4 GO:0045662 negative regulation of myoblast differentiation 4/1165 23/18722 0.0512662728905454 0.179202952643382 MBNL3/TBX3/TGFB1/CXCL10 4 GO:0050765 negative regulation of phagocytosis 4/1165 23/18722 0.0512662728905454 0.179202952643382 PLSCR1/TLR2/SNX3/CD300A 4 GO:0051882 mitochondrial depolarization 4/1165 23/18722 0.0512662728905454 0.179202952643382 PARP1/GCLM/IFI6/TSPO 4 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 4/1165 23/18722 0.0512662728905454 0.179202952643382 TYROBP/GDF15/TREM2/CD53 4 GO:0060575 intestinal epithelial cell differentiation 4/1165 23/18722 0.0512662728905454 0.179202952643382 YAP1/KLF5/IL6ST/TYMS 4 GO:0072677 eosinophil migration 4/1165 23/18722 0.0512662728905454 0.179202952643382 LGALS3/CCL4/ADAM8/CD300A 4 GO:1900273 positive regulation of long-term synaptic potentiation 4/1165 23/18722 0.0512662728905454 0.179202952643382 MME/APP/LGMN/EIF2AK4 4 GO:1903306 negative regulation of regulated secretory pathway 4/1165 23/18722 0.0512662728905454 0.179202952643382 HLA-F/SPI1/GNAI2/CD300A 4 GO:0009156 ribonucleoside monophosphate biosynthetic process 5/1165 33/18722 0.0514973031558481 0.179202952643382 UPP1/PAICS/ATIC/ADK/IMPDH2 5 GO:0010984 regulation of lipoprotein particle clearance 5/1165 33/18722 0.0514973031558481 0.179202952643382 LRPAP1/MYLIP/APOC1/TREM2/CNPY2 5 GO:0036336 dendritic cell migration 5/1165 33/18722 0.0514973031558481 0.179202952643382 CXCR4/C1QBP/EPS8/SPI1/CALR 5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 5/1165 33/18722 0.0514973031558481 0.179202952643382 FLT1/VAV3/TGFB1/FGR/LYN 5 GO:0045648 positive regulation of erythrocyte differentiation 5/1165 33/18722 0.0514973031558481 0.179202952643382 ISG15/STAT1/PRKDC/FAM210B/PRMT1 5 GO:0070570 regulation of neuron projection regeneration 5/1165 33/18722 0.0514973031558481 0.179202952643382 PTN/FLNA/KLF4/LRP1/GRN 5 GO:0150117 positive regulation of cell-substrate junction organization 5/1165 33/18722 0.0514973031558481 0.179202952643382 FERMT2/S100A10/NRP1/VEGFA/LIMS1 5 GO:1900181 negative regulation of protein localization to nucleus 5/1165 33/18722 0.0514973031558481 0.179202952643382 MAGED1/FERMT1/TRIM29/LATS2/LILRB4 5 GO:2000036 regulation of stem cell population maintenance 5/1165 33/18722 0.0514973031558481 0.179202952643382 BMP7/YAP1/PTN/NCOA3/ZC3H13 5 GO:0051092 positive regulation of NF-kappaB transcription factor activity 15/1165 152/18722 0.0516347140203731 0.179569795412859 APP/PRKCZ/TFRC/NPM1/S100A8/CIB1/PYCARD/PRDX3/TRIM22/PPIA/S100A12/TLR2/LAMTOR5/RPS3/ADAM8 15 GO:0050796 regulation of insulin secretion 16/1165 165/18722 0.0519457429106425 0.179704115465828 DPP4/LRP5/GJA1/ISL1/SYT7/MPC2/HLA-DRB1/HMGN3/SOX4/SERP1/UQCC2/BAD/GLUL/LRP1/JAK2/ENSA 16 GO:0048015 phosphatidylinositol-mediated signaling 17/1165 178/18722 0.0520010847024058 0.179704115465828 EGFR/CA8/GATA3/ERBB3/FLT1/IGF1R/NCF1/C1QBP/PIK3C2A/KLF4/PTPN6/TREM2/HCST/MYDGF/FGR/ZFP36L1/JAK2 17 GO:0001841 neural tube formation 11/1165 102/18722 0.052223371169036 0.179704115465828 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/PRKACB/SOX4/TGFB1/RPS7/VASP 11 GO:0001771 immunological synapse formation 3/1165 14/18722 0.0522496198895833 0.179704115465828 DLG1/LGALS3/MSN 3 GO:0002475 antigen processing and presentation via MHC class Ib 3/1165 14/18722 0.0522496198895833 0.179704115465828 B2M/HLA-E/HLA-F 3 GO:0002517 T cell tolerance induction 3/1165 14/18722 0.0522496198895833 0.179704115465828 HLA-B/LILRB2/LILRB4 3 GO:0006596 polyamine biosynthetic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 SMS/OAZ1/SRM 3 GO:0009071 serine family amino acid catabolic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 GLDC/GCSH/CDO1 3 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 UPP1/TYMS/DUT 3 GO:0010421 hydrogen peroxide-mediated programmed cell death 3/1165 14/18722 0.0522496198895833 0.179704115465828 MET/PAWR/PARK7 3 GO:0019321 pentose metabolic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 RPIA/DCXR/NUDT5 3 GO:0034616 response to laminar fluid shear stress 3/1165 14/18722 0.0522496198895833 0.179704115465828 ASS1/KLF2/KLF4 3 GO:0035563 positive regulation of chromatin binding 3/1165 14/18722 0.0522496198895833 0.179704115465828 GMNN/MBD2/PARP9 3 GO:0042415 norepinephrine metabolic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 GATA3/EPAS1/AKR1B1 3 GO:0043558 regulation of translational initiation in response to stress 3/1165 14/18722 0.0522496198895833 0.179704115465828 NPM1/EIF2AK1/EIF2AK4 3 GO:0060081 membrane hyperpolarization 3/1165 14/18722 0.0522496198895833 0.179704115465828 SOD2/PRKCZ/PARK7 3 GO:0060088 auditory receptor cell stereocilium organization 3/1165 14/18722 0.0522496198895833 0.179704115465828 SOD1/MYO7A/TRIOBP 3 GO:0072350 tricarboxylic acid metabolic process 3/1165 14/18722 0.0522496198895833 0.179704115465828 ASS1/IDH1/ACO2 3 GO:0009064 glutamine family amino acid metabolic process 9/1165 78/18722 0.0526113749425077 0.180837506155723 ASS1/GCLM/GFPT1/RIMKLB/ASNSD1/ATP2B4/GLUL/CLN3/SLC7A7 9 GO:0002028 regulation of sodium ion transport 10/1165 90/18722 0.0527456026625632 0.181077105654414 FXYD3/ANK3/PRSS8/SLC9A1/DLG1/FXYD5/ATP2B4/GLRX/SLC8A1/UTRN 10 GO:0032392 DNA geometric change 10/1165 90/18722 0.0527456026625632 0.181077105654414 MCM3/MCM6/MCM7/DHX36/DDX1/RUVBL1/RAD50/HMGB3/SSBP1/TOP2A 10 GO:0003229 ventricular cardiac muscle tissue development 7/1165 55/18722 0.0532057077762352 0.182433498929755 LRP2/TGFBR3/DSP/DSG2/ISL1/TBX3/TGFB1 7 GO:0043331 response to dsRNA 7/1165 55/18722 0.0532057077762352 0.182433498929755 COLEC12/NFKBIA/NPM1/PMAIP1/DHX36/DDX1/IFIT1 7 GO:0002066 columnar/cuboidal epithelial cell development 6/1165 44/18722 0.053600234393499 0.183450070518726 CDK6/YAP1/KLF5/IL6ST/BAD/TYMS 6 GO:0021762 substantia nigra development 6/1165 44/18722 0.053600234393499 0.183450070518726 HSPA5/RHOA/BASP1/YWHAE/ACTB/NDUFS3 6 GO:0042269 regulation of natural killer cell mediated cytotoxicity 6/1165 44/18722 0.053600234393499 0.183450070518726 HLA-B/HLA-A/CADM1/HLA-E/HLA-F/LILRB1 6 GO:0045787 positive regulation of cell cycle 27/1165 313/18722 0.0538129799745622 0.184065969894709 EGFR/PBX1/ADAMTS1/LRP5/SLC6A4/APP/TBX3/AIF1/BRD4/CCND3/NPM1/LGMN/RHOA/USP22/PLSCR1/CCND1/ANAPC11/MDM2/CKS2/RANBP1/CALR/IGF2/CKS1B/RAD21/APEX1/RAB11A/CCNB1 27 GO:1901991 negative regulation of mitotic cell cycle phase transition 17/1165 179/18722 0.0542818548734354 0.185556669552127 CTDSPL/WEE1/DUSP1/DLG1/FOXO4/PRKDC/SOX4/CCND1/KLF4/BRD7/MDM2/CENPF/USP47/RAD21/BABAM1/ZFP36L1/CCNB1 17 GO:0002027 regulation of heart rate 11/1165 103/18722 0.0553344820294901 0.188809998560199 DSP/DSG2/ADRB1/ISL1/DSC2/EPAS1/AKAP9/MDM2/YWHAE/GCH1/SLC8A1 11 GO:0019395 fatty acid oxidation 11/1165 103/18722 0.0553344820294901 0.188809998560199 SLC27A2/ECHDC2/ADH5/ECHS1/ECI1/ECI2/ETFA/ECH1/HADHB/ACADVL/ECHDC1 11 GO:0090277 positive regulation of peptide hormone secretion 11/1165 103/18722 0.0553344820294901 0.188809998560199 EGFR/GJA1/ISL1/MPC2/HLA-DRB1/SOX4/SERP1/BAD/GLUL/LRP1/JAK2 11 GO:0035303 regulation of dephosphorylation 13/1165 128/18722 0.05543456509812 0.18894615580783 SLC39A10/HSP90B1/HSP90AB1/PTPRC/LGALS3/TGFB1/LILRB2/PPIA/GNAI2/YWHAE/CD300A/JAK2/ENSA 13 GO:0061180 mammary gland epithelium development 8/1165 67/18722 0.0554459650142048 0.18894615580783 LRP5/GATA3/TBX3/IRF6/CEBPB/GPX1/CCND1/JAK2 8 GO:0046942 carboxylic acid transport 24/1165 273/18722 0.0555019177914273 0.18894615580783 LRP2/SLC26A2/SLC16A12/SLC38A1/GJA1/FOLR1/SLC38A9/SLC19A1/PTGES/SLC13A3/ITGB1/MPC2/SLC5A6/SLC11A1/ARL6IP5/SLC1A3/SLCO2B1/SLC16A3/SLC25A13/SLC25A1/CLN3/SYK/AQP9/SLC7A7 24 GO:0046394 carboxylic acid biosynthetic process 27/1165 314/18722 0.0555426967901157 0.18894615580783 SLC27A2/ACSS1/MGST3/HACD3/PTGES/ASS1/MGLL/DEGS1/ADI1/GSTP1/ASNSD1/MTR/NDUFAB1/APOC1/TECR/ATP2B4/CD74/OSBPL9/SLC1A3/GPX4/PARK7/KYNU/AASDHPPT/GLUL/CLN3/SYK/ACADVL 27 GO:0060249 anatomical structure homeostasis 27/1165 314/18722 0.0555426967901157 0.18894615580783 EGFR/LYZ/SLC2A1/JAM3/LSR/GJA1/LAMC1/B2M/ALDOA/TFRC/SOD1/EPAS1/TJP1/YAP1/SNX10/CTSH/PRDX1/ITGB1/AKR1B1/ATP2B1/PECAM1/VEGFA/OAS1/LIPA/ACTB/SYK/ADAM8 27 GO:0017038 protein import 19/1165 206/18722 0.0557956984895499 0.189691856827282 CDH1/FERMT1/HSPD1/GLI3/HSP90AB1/RPL23/NFKBIA/APOE/HSP90AA1/FLNA/RAN/TGFB1/TXNIP/ROMO1/TNPO1/HSPA8/SYK/JAK2/NUP214 19 GO:0051492 regulation of stress fiber assembly 10/1165 91/18722 0.0561083654336247 0.190639379648266 MET/TACSTD2/TJP1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/WASF2/STMN1 10 GO:0032272 negative regulation of protein polymerization 9/1165 79/18722 0.0562506347191062 0.191007146205894 KANK1/TMSB4X/KANK4/SCIN/TMSB10/EPS8/TRIOBP/STMN1/ADD3 9 GO:0090150 establishment of protein localization to membrane 23/1165 260/18722 0.0565778096545058 0.192001962267679 EGFR/TCAF1/KRT18/NSG1/ANK3/CD24/NCF1/VAMP5/HSP90AA1/GOLGA4/HSPA5/SIL1/TIMM13/CIB1/SRP14/NMT1/HRAS/CCDC47/ROMO1/FIS1/CLN3/RAB11A/TIMM8B 23 GO:0016052 carbohydrate catabolic process 15/1165 154/18722 0.0566608961118849 0.19216774010635 LRP5/LDHA/APP/ALDOA/AGL/GAPDH/FBP1/TPI1/FUT8/PGK1/PKM/ENO1/BAD/NUDT5/GK 15 GO:0034767 positive regulation of ion transmembrane transport 16/1165 167/18722 0.0567702092358334 0.19242221282653 TCAF1/CTSS/TMSB4X/ANK3/KCNN4/IFNGR2/SLC9A1/ITGB1/FLNA/AKAP9/GSTO1/TREM2/GLRX/VMP1/CXCL10/NDUFA4 16 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 34/1165 412/18722 0.0568615016208053 0.192615334096307 KLHL42/HSP90B1/HSP90AB1/DDB1/SIAH1/TBL1X/PSMD14/PSMD7/SKP2/HSPA5/VCP/DAB2/SIAH2/PSMD1/PSMC1/PSMC3/UBE4B/PSMB5/PSMC6/UBE2H/ANAPC11/MDM2/USP14/PARK7/RAD23B/WWP1/CCDC47/CALR/PSMC4/UFL1/PSMD2/CD2AP/PSMD6/UBXN4 34 GO:0002446 neutrophil mediated immunity 5/1165 34/18722 0.0574113982210141 0.193659962869322 ANXA3/STXBP2/SPI1/TREM1/SYK 5 GO:0006270 DNA replication initiation 5/1165 34/18722 0.0574113982210141 0.193659962869322 MCM3/MCM6/CCNE1/MCM7/ORC6 5 GO:0010922 positive regulation of phosphatase activity 5/1165 34/18722 0.0574113982210141 0.193659962869322 SLC39A10/HSP90AB1/PTPRC/CD300A/JAK2 5 GO:0044319 wound healing, spreading of cells 5/1165 34/18722 0.0574113982210141 0.193659962869322 FERMT1/CD44/FERMT2/RHOA/FLNA 5 GO:0051973 positive regulation of telomerase activity 5/1165 34/18722 0.0574113982210141 0.193659962869322 PKIB/HSP90AB1/HSP90AA1/CCT2/KLF4 5 GO:0090505 epiboly involved in wound healing 5/1165 34/18722 0.0574113982210141 0.193659962869322 FERMT1/CD44/FERMT2/RHOA/FLNA 5 GO:0098751 bone cell development 5/1165 34/18722 0.0574113982210141 0.193659962869322 FBN1/TYROBP/WASF2/PTPN6/LILRB1 5 GO:0031122 cytoplasmic microtubule organization 7/1165 56/18722 0.05768968591644 0.19424847453448 DLG1/RHOA/CLIP1/CIB1/DST/PCM1/RAB11A 7 GO:0048008 platelet-derived growth factor receptor signaling pathway 7/1165 56/18722 0.05768968591644 0.19424847453448 ARID5B/NRP1/VEGFA/PIK3C2A/TXNIP/LRP1/JAK2 7 GO:0051058 negative regulation of small GTPase mediated signal transduction 7/1165 56/18722 0.05768968591644 0.19424847453448 KANK1/MET/RASA1/ITGB1/FBP1/STMN1/CD2AP 7 GO:1903311 regulation of mRNA metabolic process 25/1165 288/18722 0.0580973223230025 0.195503759112118 MBNL3/MBNL2/NPM1/ZFP36/C1QBP/VIM/DHX36/FUS/SLC11A1/SERBP1/CARHSP1/PABPC1/RBM39/PRDX6/YBX1/SF1/NCL/SRSF2/APEX1/ZFP36L1/RBM3/HSPA8/CIRBP/CCNB1/SON 25 GO:0001654 eye development 31/1165 371/18722 0.0583620830514452 0.195682406827383 FBN1/TENM3/FBN2/EFEMP1/PBX1/BMP7/LRP5/SMOC1/SERPINF1/GATA3/TFAP2A/GLI3/OBSL1/FLT1/NRP1/MYO7A/MFAP5/PTN/ATP2B1/DLG1/VEGFA/VIM/SKIL/PFDN5/KLF4/ATP2B4/HDAC2/C12orf57/IMPDH2/SCO2/HMGN1 31 GO:0002021 response to dietary excess 4/1165 24/18722 0.0586036212144718 0.195682406827383 ADRB1/APOE/GDF15/SORL1 4 GO:0003148 outflow tract septum morphogenesis 4/1165 24/18722 0.0586036212144718 0.195682406827383 LRP2/ISL1/NRP2/NRP1 4 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 4/1165 24/18722 0.0586036212144718 0.195682406827383 TYMP/UPP1/TYMS/DUT 4 GO:0030810 positive regulation of nucleotide biosynthetic process 4/1165 24/18722 0.0586036212144718 0.195682406827383 TMSB4X/VCP/TREM2/ENO1 4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 4/1165 24/18722 0.0586036212144718 0.195682406827383 KLF2/CEBPB/HSPA5/VEGFA 4 GO:0038095 Fc-epsilon receptor signaling pathway 4/1165 24/18722 0.0586036212144718 0.195682406827383 FCER1G/VAV3/SYK/LYN 4 GO:0060561 apoptotic process involved in morphogenesis 4/1165 24/18722 0.0586036212144718 0.195682406827383 BMP7/LRP5/SPI1/TNFRSF1B 4 GO:0072530 purine-containing compound transmembrane transport 4/1165 24/18722 0.0586036212144718 0.195682406827383 SLC19A1/SLC25A5/SLC29A1/AQP9 4 GO:0090343 positive regulation of cell aging 4/1165 24/18722 0.0586036212144718 0.195682406827383 B2M/PAWR/ABI3/YPEL3 4 GO:1900373 positive regulation of purine nucleotide biosynthetic process 4/1165 24/18722 0.0586036212144718 0.195682406827383 TMSB4X/VCP/TREM2/ENO1 4 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 4/1165 24/18722 0.0586036212144718 0.195682406827383 SOD2/CYBA/SLC5A3/PARK7 4 GO:2001026 regulation of endothelial cell chemotaxis 4/1165 24/18722 0.0586036212144718 0.195682406827383 MET/TMSB4X/LGMN/VEGFA 4 GO:0003254 regulation of membrane depolarization 6/1165 45/18722 0.0587352229164937 0.19577245025551 GJA5/ANK3/PARP1/GCLM/IFI6/TSPO 6 GO:0048538 thymus development 6/1165 45/18722 0.0587352229164937 0.19577245025551 PBX1/LMO4/GATA3/SOD1/PRDX2/PRKDC 6 GO:0071354 cellular response to interleukin-6 6/1165 45/18722 0.0587352229164937 0.19577245025551 YAP1/SPI1/IL6ST/JAK1/PHB/JAK2 6 GO:0007009 plasma membrane organization 14/1165 142/18722 0.0589915212547258 0.196473605204588 SPESP1/CXCR4/FOLR1/SYT7/ANK3/SOD1/FNBP1L/DEGS1/PTPRC/CD9/PLSCR1/SERP1/WASL/CLN3 14 GO:0008361 regulation of cell size 17/1165 181/18722 0.0590505918368323 0.196473605204588 SEMA6A/SEMA6D/HSP90AB1/KCNN4/NRP1/NPM1/APOE/GOLGA4/RHOA/VEGFA/VAV3/MSN/CLN3/LAMTOR5/RAB11A/LRP1/TMEM123 17 GO:0030323 respiratory tube development 17/1165 181/18722 0.0590505918368323 0.196473605204588 LAMA5/EGFR/MME/DAG1/DLG5/GLI3/EPAS1/GPC3/DPPA4/YAP1/KLF2/CTSH/PTN/VEGFA/MAN1A2/HSPB11/LIPA 17 GO:0051051 negative regulation of transport 38/1165 470/18722 0.0593137713618838 0.197232345174321 FERMT1/GJA1/GABRE/ANK3/LMAN1/FRMD4A/ERBB3/NDFIP2/APOE/COMT/HLA-F/OAZ1/LRPAP1/C4orf3/LGALS3/PNKD/SPI1/PLSCR1/APOC1/CD74/ARL6IP5/GSTO1/LILRB2/PARK7/RSAD2/TLR2/LILRB1/GNAI2/YWHAE/FIS1/BST2/ISCU/ERP29/SNX3/VDAC1/PEA15/CD300A/TNFRSF1B 38 GO:0009988 cell-cell recognition 8/1165 68/18722 0.0595729265599264 0.197859666734241 SPESP1/FOLR1/ALDOA/DLG1/CCT2/LGALS3/CD9/MSN 8 GO:1902305 regulation of sodium ion transmembrane transport 8/1165 68/18722 0.0595729265599264 0.197859666734241 FXYD3/ANK3/SLC9A1/DLG1/FXYD5/ATP2B4/GLRX/UTRN 8 GO:0006959 humoral immune response 27/1165 317/18722 0.0609707681937144 0.202382567635316 LYZ/HLA-A/GATA3/HLA-E/FCN1/CD59/GAPDH/C1QA/C1QB/C1QC/HLA-DRB1/PTPRC/C1QBP/CD55/A2M/TREM1/CD46/SLC11A1/PTPN6/TREM2/PHB/S100A12/CXCL10/ROMO1/DEFB1/CFP/CD83 27 GO:0042476 odontogenesis 13/1165 130/18722 0.0612701205848503 0.202692262740043 LAMA5/LAMB1/BMP7/TFAP2A/PERP/GLI3/SNX10/BSG/HTRA1/RHOA/HDAC2/CSF3R/ZNF22 13 GO:0048017 inositol lipid-mediated signaling 17/1165 182/18722 0.0615400160281178 0.202692262740043 EGFR/CA8/GATA3/ERBB3/FLT1/IGF1R/NCF1/C1QBP/PIK3C2A/KLF4/PTPN6/TREM2/HCST/MYDGF/FGR/ZFP36L1/JAK2 17 GO:0031214 biomineral tissue development 16/1165 169/18722 0.0618949134251146 0.202692262740043 FBN2/SRGN/BMP7/LGR4/ISG15/TFAP2A/NOTUM/GPC3/SNX10/PTN/ATP2B1/CEBPB/TGFB1/FGR/SLC8A1/ATRAID 16 GO:0040029 regulation of gene expression, epigenetic 11/1165 105/18722 0.061920832558708 0.202692262740043 KLF2/TFAP2C/HELLS/DNMT1/GPX1/DNMT3A/SPI1/CDYL/IGF2/IFI16/MBD2 11 GO:0002070 epithelial cell maturation 3/1165 15/18722 0.0623846133916741 0.202692262740043 TFCP2L1/AKR1B1/TYMS 3 GO:0002730 regulation of dendritic cell cytokine production 3/1165 15/18722 0.0623846133916741 0.202692262740043 DHX36/DDX1/BST2 3 GO:0006268 DNA unwinding involved in DNA replication 3/1165 15/18722 0.0623846133916741 0.202692262740043 MCM6/MCM7/SSBP1 3 GO:0009263 deoxyribonucleotide biosynthetic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 ADK/TYMS/DUT 3 GO:0010763 positive regulation of fibroblast migration 3/1165 15/18722 0.0623846133916741 0.202692262740043 ITGB1/TGFB1/SLC8A1 3 GO:0010940 positive regulation of necrotic cell death 3/1165 15/18722 0.0623846133916741 0.202692262740043 HEBP2/TSPO/BNIP3 3 GO:0031958 corticosteroid receptor signaling pathway 3/1165 15/18722 0.0623846133916741 0.202692262740043 CALR/PHB/JAK2 3 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 3/1165 15/18722 0.0623846133916741 0.202692262740043 ISL1/SYK/LILRA2 3 GO:0033599 regulation of mammary gland epithelial cell proliferation 3/1165 15/18722 0.0623846133916741 0.202692262740043 GATA3/GPX1/CCND1 3 GO:0042074 cell migration involved in gastrulation 3/1165 15/18722 0.0623846133916741 0.202692262740043 LRP5/AMOT/GPC3 3 GO:0042182 ketone catabolic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 PNKD/PARK7/KYNU 3 GO:0042976 activation of Janus kinase activity 3/1165 15/18722 0.0623846133916741 0.202692262740043 PRLR/CD300A/JAK2 3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 3/1165 15/18722 0.0623846133916741 0.202692262740043 CD44/CD74/MDM2 3 GO:0044793 negative regulation by host of viral process 3/1165 15/18722 0.0623846133916741 0.202692262740043 PSMC3/EIF2AK4/NUCKS1 3 GO:0045064 T-helper 2 cell differentiation 3/1165 15/18722 0.0623846133916741 0.202692262740043 GATA3/PRKCZ/CD86 3 GO:0045346 regulation of MHC class II biosynthetic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 SPI1/HDAC2/JAK2 3 GO:0051127 positive regulation of actin nucleation 3/1165 15/18722 0.0623846133916741 0.202692262740043 SCIN/WASF2/WASL 3 GO:0051938 L-glutamate import 3/1165 15/18722 0.0623846133916741 0.202692262740043 ITGB1/ARL6IP5/SLC1A3 3 GO:0072075 metanephric mesenchyme development 3/1165 15/18722 0.0623846133916741 0.202692262740043 BMP7/STAT1/BASP1 3 GO:0090594 inflammatory response to wounding 3/1165 15/18722 0.0623846133916741 0.202692262740043 TIMP1/TGFB1/GRN 3 GO:0097468 programmed cell death in response to reactive oxygen species 3/1165 15/18722 0.0623846133916741 0.202692262740043 MET/PAWR/PARK7 3 GO:0098712 L-glutamate import across plasma membrane 3/1165 15/18722 0.0623846133916741 0.202692262740043 ITGB1/ARL6IP5/SLC1A3 3 GO:1901660 calcium ion export 3/1165 15/18722 0.0623846133916741 0.202692262740043 ATP2B1/ATP2B4/YWHAE 3 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 3/1165 15/18722 0.0623846133916741 0.202692262740043 CCT2/RUVBL1/NHP2 3 GO:1905146 lysosomal protein catabolic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 LRP2/CLN3/LRP1 3 GO:1905288 vascular associated smooth muscle cell apoptotic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 SOD2/PDCD4/DNMT1 3 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 3/1165 15/18722 0.0623846133916741 0.202692262740043 SOD2/PDCD4/DNMT1 3 GO:0002011 morphogenesis of an epithelial sheet 7/1165 57/18722 0.0624001835052191 0.202692262740043 BMP7/DAG1/FERMT1/CD44/FERMT2/RHOA/FLNA 7 GO:0050891 multicellular organismal water homeostasis 7/1165 57/18722 0.0624001835052191 0.202692262740043 MET/CLDN4/LSR/ATP6V1B1/AKR1B1/PRKACB/STMN1 7 GO:0051205 protein insertion into membrane 7/1165 57/18722 0.0624001835052191 0.202692262740043 EGFR/HSP90AA1/TIMM13/NMT1/CCDC47/ROMO1/TIMM8B 7 GO:0060760 positive regulation of response to cytokine stimulus 7/1165 57/18722 0.0624001835052191 0.202692262740043 CXCR4/LAPTM5/CD74/TREM2/IRF7/TLR2/PARP9 7 GO:0061005 cell differentiation involved in kidney development 7/1165 57/18722 0.0624001835052191 0.202692262740043 LGR4/GATA3/GLI3/CD24/YAP1/STAT1/BASP1 7 GO:0097120 receptor localization to synapse 7/1165 57/18722 0.0624001835052191 0.202692262740043 DAG1/NSG1/TYROBP/PRKCZ/DLG1/HRAS/RAB11A 7 GO:0043588 skin development 23/1165 263/18722 0.0626747593847104 0.203466410888594 LAMA5/EGFR/LGR5/MET/ITGB4/DSP/CLDN4/ITGA6/LGR4/FERMT1/LSR/FRAS1/EXPH5/DHCR24/YAP1/ZFP36/IRF6/TXNIP/OPN3/NCOA3/STMN1/HDAC2/ZFP36L1 23 GO:0016072 rRNA metabolic process 21/1165 236/18722 0.0629530572438036 0.203898159439971 RPS17/RPS21/MRPL1/RPS27/PRKDC/RPS28/SNU13/DDX27/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/BRIX1/RPS7/NHP2/RPS16/NOP56/IMP3/RPL10A 21 GO:0030072 peptide hormone secretion 21/1165 236/18722 0.0629530572438036 0.203898159439971 EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/SYT7/MPC2/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/PARK7/UQCC2/CCDC186/BAD/GLUL/LRP1/JAK2/ENSA 21 GO:0046395 carboxylic acid catabolic process 21/1165 236/18722 0.0629530572438036 0.203898159439971 SLC27A2/GLDC/QPRT/GCSH/ECHDC2/ECHS1/CDO1/PCCB/IL4I1/AIG1/ECI1/ECI2/ATP2B4/ETFA/ECH1/KYNU/HADHB/GLUL/ACADVL/ECHDC1/NPL 21 GO:0048738 cardiac muscle tissue development 21/1165 236/18722 0.0629530572438036 0.203898159439971 LRP2/TGFBR3/GJA5/DSP/BMP7/DSG2/GJA1/ISL1/OBSL1/MSX2/TBX3/YAP1/SLC9A1/ITGB1/VEGFA/TGFB1/CALR/SLC8A1/PRMT1/NDUFV2/CCNB1 21 GO:0007589 body fluid secretion 10/1165 93/18722 0.0632483784847357 0.204618529357246 EGFR/CYBA/PRLR/KCNN4/CDO1/VEGFA/CCND1/SLC29A1/OAS2/NME1 10 GO:0106027 neuron projection organization 10/1165 93/18722 0.0632483784847357 0.204618529357246 APP/IGF1R/EFNA1/APOE/LGMN/DHX36/TREM2/WASL/DOCK10/ABI3 10 GO:0045446 endothelial cell differentiation 12/1165 118/18722 0.0634354005855497 0.205024893057585 MET/NR2F2/CXCR4/FSTL1/TJP1/NRP1/PTN/ID1/GPX1/PECAM1/VEGFA/MSN 12 GO:0043393 regulation of protein binding 18/1165 196/18722 0.0634470406629299 0.205024893057585 TGFBR3/B2M/PHLDA2/APP/HSP90AB1/NRP1/APOE/ID1/DAB2/BAG2/LRPAP1/IFIT2/RAN/PARK7/IFIT1/ACTB/LRP1/SORL1 18 GO:0006084 acetyl-CoA metabolic process 5/1165 35/18722 0.0636979935090346 0.205127273417218 ACSS1/MPC2/DLD/PMVK/KYNU 5 GO:0032232 negative regulation of actin filament bundle assembly 5/1165 35/18722 0.0636979935090346 0.205127273417218 MET/TACSTD2/TJP1/WASF2/STMN1 5 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 5/1165 35/18722 0.0636979935090346 0.205127273417218 ISL1/PARP1/YAP1/SKP2/UFL1 5 GO:0034405 response to fluid shear stress 5/1165 35/18722 0.0636979935090346 0.205127273417218 GJA1/ASS1/KLF2/KLF4/TFPI2 5 GO:0090504 epiboly 5/1165 35/18722 0.0636979935090346 0.205127273417218 FERMT1/CD44/FERMT2/RHOA/FLNA 5 GO:0098801 regulation of renal system process 5/1165 35/18722 0.0636979935090346 0.205127273417218 GJA5/GJA1/CYBA/COMT/GNAI2 5 GO:0015807 L-amino acid transport 8/1165 69/18722 0.0638881284497803 0.205534126931072 SLC38A1/SLC38A9/ITGB1/SLC11A1/ARL6IP5/SLC1A3/SLC25A13/SLC7A7 8 GO:0006096 glycolytic process 9/1165 81/18722 0.0640074209648162 0.205534126931072 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/PGK1/PKM/ENO1 9 GO:0010833 telomere maintenance via telomere lengthening 9/1165 81/18722 0.0640074209648162 0.205534126931072 PKIB/PARP1/HSP90AB1/HSP90AA1/CCT2/DHX36/RAD50/RFC1/NHP2 9 GO:0014032 neural crest cell development 9/1165 81/18722 0.0640074209648162 0.205534126931072 SEMA6A/LAMA5/SEMA6D/BMP7/ISL1/NRP2/FOLR1/NRP1/PDCD6 9 GO:2000106 regulation of leukocyte apoptotic process 9/1165 81/18722 0.0640074209648162 0.205534126931072 SLC39A10/EFNA1/LGALS3/CD74/IRF7/TSC22D3/LILRB1/ADAM8/LYN 9 GO:0001974 blood vessel remodeling 6/1165 46/18722 0.0641536022099587 0.205650582069959 EPAS1/TGM2/FLNA/CST3/TGFB1/MDM2 6 GO:0060976 coronary vasculature development 6/1165 46/18722 0.0641536022099587 0.205650582069959 LRP2/ADAMTS6/TGFBR3/GPC3/NRP1/VEGFA 6 GO:2000107 negative regulation of leukocyte apoptotic process 6/1165 46/18722 0.0641536022099587 0.205650582069959 SLC39A10/EFNA1/CD74/IRF7/TSC22D3/LILRB1 6 GO:1902600 proton transmembrane transport 15/1165 157/18722 0.0648124552802169 0.207644013406311 ATP6V1B1/TMSB4X/ATP6V1C2/SLC9A1/SLC25A3/CYB5A/SLC25A5/UQCR10/ATP6V1F/COX4I1/STOML2/PARK7/ATP6V1E1/NDUFA4/COX6A1 15 GO:0006401 RNA catabolic process 24/1165 278/18722 0.065488152059243 0.209569553881717 LIN28B/KCNQ1OT1/RNASET2/NPM1/SLIRP/ZFP36/VIM/LSM7/DHX36/FUS/SLC11A1/LRPPRC/ISG20/SERBP1/CARHSP1/PABPC1/OAS2/YBX1/SND1/APEX1/ZFP36L1/PNRC2/CIRBP/TNFRSF1B 24 GO:0022898 regulation of transmembrane transporter activity 24/1165 278/18722 0.065488152059243 0.209569553881717 TCAF1/GJA1/FXYD3/CTSS/APP/TMSB4X/ANK3/IFNGR2/SLC9A1/KCNG1/ITGB1/DLG1/FXYD5/C4orf3/AKAP9/GSTO1/TREM2/PARK7/GLRX/VMP1/YWHAE/ACTB/UTRN/NDUFA4 24 GO:0009914 hormone transport 26/1165 306/18722 0.0664536040728528 0.211381081493537 EGFR/DPP4/LRP5/GJA1/ISL1/FAM3B/GATA3/SYT7/TBX3/MPC2/HLA-DRB1/HMGN3/SOX4/CAMK2G/SERP1/PARK7/UQCC2/CCDC186/RETN/BAD/GLUL/CGA/LRP1/JAK2/ENSA/LYN 26 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 4/1165 25/18722 0.0664684854509339 0.211381081493537 GJA5/GJA1/CYBA/RHOA 4 GO:0003094 glomerular filtration 4/1165 25/18722 0.0664684854509339 0.211381081493537 GJA5/GJA1/CYBA/SULF2 4 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 4/1165 25/18722 0.0664684854509339 0.211381081493537 AK3/TYMS/NME1/DUT 4 GO:0010447 response to acidic pH 4/1165 25/18722 0.0664684854509339 0.211381081493537 SERPINF1/CTSS/SLC9A1/LGMN 4 GO:0010996 response to auditory stimulus 4/1165 25/18722 0.0664684854509339 0.211381081493537 USP53/PTN/SLC1A3/CXCL10 4 GO:0016540 protein autoprocessing 4/1165 25/18722 0.0664684854509339 0.211381081493537 CTSL/PARP1/PISD/AFG3L2 4 GO:0031579 membrane raft organization 4/1165 25/18722 0.0664684854509339 0.211381081493537 S100A10/DLG1/PTPRC/CLN3 4 GO:0032469 endoplasmic reticulum calcium ion homeostasis 4/1165 25/18722 0.0664684854509339 0.211381081493537 APP/TGM2/CCDC47/FIS1 4 GO:0042832 defense response to protozoan 4/1165 25/18722 0.0664684854509339 0.211381081493537 GBP2/GBP4/SLC11A1/HRAS 4 GO:0061436 establishment of skin barrier 4/1165 25/18722 0.0664684854509339 0.211381081493537 MET/CLDN4/LSR/STMN1 4 GO:0007409 axonogenesis 34/1165 418/18722 0.0667001218436451 0.211997612632152 SEMA6A/LAMA5/SEMA6D/BMP7/DAG1/EPHB4/ISL1/APP/NRP2/GATA3/ANK3/GLI3/HSP90AB1/EFNA1/S100A6/NRP1/SIAH1/PARD6B/APOE/HSP90AA1/ITGB1/BSG/GOLGA4/DLX5/VEGFA/SKIL/AFG3L2/STMN1/VASP/C12orf57/RHOG/ACTB/RAB11A/LRP1 34 GO:0014020 primary neural tube formation 10/1165 94/18722 0.0670280160481613 0.212798786243399 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/PRKACB/TGFB1/RPS7/VASP 10 GO:0032091 negative regulation of protein binding 10/1165 94/18722 0.0670280160481613 0.212798786243399 B2M/ID1/DAB2/BAG2/LRPAP1/IFIT2/PARK7/IFIT1/ACTB/SORL1 10 GO:0110148 biomineralization 16/1165 171/18722 0.0673257724409121 0.213301064776587 FBN2/SRGN/BMP7/LGR4/ISG15/TFAP2A/NOTUM/GPC3/SNX10/PTN/ATP2B1/CEBPB/TGFB1/FGR/SLC8A1/ATRAID 16 GO:0010043 response to zinc ion 7/1165 58/18722 0.0673382303196352 0.213301064776587 SOD2/PARP1/ASS1/GGH/S100A8/CRIP1/TSPO 7 GO:0086065 cell communication involved in cardiac conduction 7/1165 58/18722 0.0673382303196352 0.213301064776587 GJA5/DSP/DSG2/GJA1/DSC2/FLNA/SLC8A1 7 GO:1902808 positive regulation of cell cycle G1/S phase transition 7/1165 58/18722 0.0673382303196352 0.213301064776587 EGFR/ADAMTS1/AIF1/CCND3/CCND1/MDM2/APEX1 7 GO:0035264 multicellular organism growth 13/1165 132/18722 0.0675023404537 0.213546630663288 ADRB1/APP/SOD1/ARID5B/KLF2/LGMN/PPIB/AFG3L2/ATF5/PLAC8/GDF15/IGF2/ZFP36L1 13 GO:0072175 epithelial tube formation 13/1165 132/18722 0.0675023404537 0.213546630663288 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/GATA3/IRX2/PRKACB/SOX4/TGFB1/RPS7/VASP 13 GO:0050807 regulation of synapse organization 19/1165 211/18722 0.0675298894401098 0.213546630663288 SRGN/DAG1/DLG5/APP/NRP2/EFNA1/APOE/PTN/TUBB/VCP/RHOA/DHX36/TREM2/LILRB2/ARF4/TLR2/CLN3/ABI3/HSPA8 19 GO:0006757 ATP generation from ADP 9/1165 82/18722 0.0681274033605205 0.215193649444345 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/PGK1/PKM/ENO1 9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 9/1165 82/18722 0.0681274033605205 0.215193649444345 TIMP3/PMAIP1/GPX1/LGALS3/SKIL/SPI1/PARK7/BAD/PEA15 9 GO:0070830 bicellular tight junction assembly 8/1165 70/18722 0.0683926492881448 0.215909977758356 CLDN4/GJA1/TJP1/MARVELD3/MPP7/CLDN7/DLG1/PECAM1 8 GO:0050864 regulation of B cell activation 18/1165 198/18722 0.0685479738511226 0.216278683095195 TYROBP/SLC39A10/TFRC/PAWR/LAPTM5/PTPRC/IL4I1/VAV3/CD74/PTPN6/TNFSF13B/TGFB1/BAD/MNDA/ZFP36L1/SYK/CD300A/LYN 18 GO:0032526 response to retinoic acid 11/1165 107/18722 0.0690001439641137 0.217583038241893 SLC6A4/GJA1/SERPINF1/PTGES/YAP1/DUSP1/YES1/CTSH/KLF4/HDAC2/LYN 11 GO:0007369 gastrulation 17/1165 185/18722 0.0694363986131689 0.218835769464187 COL4A2/LAMB1/ITGB4/BMP7/WLS/LRP5/DAG1/GJA1/AMOT/GPC3/DUSP5/ITGB5/DUSP1/ITGB1/KLF4/DLD/RTF1 17 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 6/1165 47/18722 0.0698554975652169 0.219417407853141 ENPEP/MME/ADRB1/SOD2/CYBA/RHOA 6 GO:0010712 regulation of collagen metabolic process 6/1165 47/18722 0.0698554975652169 0.219417407853141 ITGB1/VIM/CST3/TGFB1/HDAC2/SUCO 6 GO:0010761 fibroblast migration 6/1165 47/18722 0.0698554975652169 0.219417407853141 ARID5B/PDLIM1/ITGB1/TGFB1/CLN3/SLC8A1 6 GO:0043114 regulation of vascular permeability 6/1165 47/18722 0.0698554975652169 0.219417407853141 TJP1/FERMT2/APOE/YES1/VEGFA/TGFB1 6 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 6/1165 47/18722 0.0698554975652169 0.219417407853141 EPAS1/KLF2/CEBPB/HSPA5/VEGFA/JUN 6 GO:0045581 negative regulation of T cell differentiation 6/1165 47/18722 0.0698554975652169 0.219417407853141 GLI3/PRDX2/FGL2/IRF1/CD74/LILRB4 6 GO:0034765 regulation of ion transmembrane transport 39/1165 491/18722 0.0699665136650896 0.219643199777488 GJA5/TCAF1/FXYD3/TMEM37/CLIC3/CTSS/APP/TMSB4X/ANK3/CYBA/CYBB/TSPAN13/KCNN4/IFNGR2/SLC9A1/KCNG1/ITGB1/DLG1/FXYD5/FLNA/C4orf3/ATP2B4/AKAP9/ARL6IP5/PTPN6/GSTO1/TREM2/PARK7/GLRX/VMP1/CXCL10/YWHAE/ISCU/CATSPER1/SLC8A1/UTRN/VDAC1/NDUFA4/LYN 39 GO:0048675 axon extension 12/1165 120/18722 0.0701842796734662 0.219879482502906 SEMA6A/SEMA6D/NRP2/HSP90AB1/NRP1/APOE/HSP90AA1/ITGB1/GOLGA4/VEGFA/RAB11A/LRP1 12 GO:0009225 nucleotide-sugar metabolic process 5/1165 36/18722 0.0703551666800675 0.219879482502906 EXTL2/FUT8/GFPT1/UGP2/MGAT1 5 GO:0017004 cytochrome complex assembly 5/1165 36/18722 0.0703551666800675 0.219879482502906 CYBA/COA4/UQCC2/COX20/SCO2 5 GO:0042092 type 2 immune response 5/1165 36/18722 0.0703551666800675 0.219879482502906 GATA3/PRKCZ/CD86/CD74/RSAD2 5 GO:0060338 regulation of type I interferon-mediated signaling pathway 5/1165 36/18722 0.0703551666800675 0.219879482502906 ISG15/HSP90AB1/PTPN6/IRF7/OAS1 5 GO:0090313 regulation of protein targeting to membrane 5/1165 36/18722 0.0703551666800675 0.219879482502906 TCAF1/ANK3/CIB1/HRAS/FIS1 5 GO:1901658 glycosyl compound catabolic process 5/1165 36/18722 0.0703551666800675 0.219879482502906 APOBEC3A/FUCA1/UPP1/FUCA2/PNP 5 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 5/1165 36/18722 0.0703551666800675 0.219879482502906 CD44/SKIL/CD74/USP47/RPS3 5 GO:0008585 female gonad development 10/1165 95/18722 0.0709486864315808 0.221487751357321 NR2F2/ADAMTS1/SOD1/ARID5B/IDH1/CEBPB/HSPA5/VEGFA/UBB/RETN 10 GO:0042982 amyloid precursor protein metabolic process 10/1165 95/18722 0.0709486864315808 0.221487751357321 NSG1/PAWR/DHCR24/EFNA1/ITM2C/APOE/DLG1/CLN3/SORL1/LYN 10 GO:0006470 protein dephosphorylation 24/1165 281/18722 0.072047441451504 0.224130239631153 CTDSPL/PTPN14/SLC39A10/HSP90B1/HSP90AB1/DUSP5/DUSP14/DUSP1/DLG1/PGP/PTPRC/LGALS3/CAMK2G/PTPN6/TGFB1/LILRB2/PTPRA/PPIA/GNAI2/YWHAE/PTP4A1/CD300A/JAK2/ENSA 24 GO:0016054 organic acid catabolic process 21/1165 240/18722 0.0723481656982605 0.224130239631153 SLC27A2/GLDC/QPRT/GCSH/ECHDC2/ECHS1/CDO1/PCCB/IL4I1/AIG1/ECI1/ECI2/ATP2B4/ETFA/ECH1/KYNU/HADHB/GLUL/ACADVL/ECHDC1/NPL 21 GO:0050851 antigen receptor-mediated signaling pathway 21/1165 240/18722 0.0723481656982605 0.224130239631153 HLA-A/GATA3/SLC39A10/PAWR/LAPTM5/KCNN4/GBP1/HLA-DRB1/HLA-DPB1/PTPRC/VAV3/LGALS3/PTPN6/STOML2/LILRB4/HRAS/MNDA/RPS3/SYK/CD300A/LYN 21 GO:0050886 endocrine process 9/1165 83/18722 0.0724096569570671 0.224130239631153 ENPEP/MME/GJA1/GATA3/CYBA/TBX3/RHOA/RETN/CGA 9 GO:1901292 nucleoside phosphate catabolic process 9/1165 83/18722 0.0724096569570671 0.224130239631153 TYMP/HINT1/NUDT4/VCP/UPP1/NUDT5/DNPH1/PNP/DUT 9 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 7/1165 59/18722 0.0725043213102339 0.224130239631153 FLT1/VAV3/KLF4/TGFB1/FGR/SOCS3/LYN 7 GO:0007173 epidermal growth factor receptor signaling pathway 11/1165 108/18722 0.0727269208530097 0.224130239631153 EGFR/EFEMP1/NCF1/IFI6/PLAUR/GRB2/PIK3C2A/TGFB1/VPS25/ARF4/SNX6 11 GO:0033138 positive regulation of peptidyl-serine phosphorylation 11/1165 108/18722 0.0727269208530097 0.224130239631153 EGFR/APP/CD44/TFRC/HSP90AB1/HSP90AA1/VEGFA/ATP2B4/AKAP9/TGFB1/PARK7 11 GO:0034440 lipid oxidation 11/1165 108/18722 0.0727269208530097 0.224130239631153 SLC27A2/ECHDC2/ADH5/ECHS1/ECI1/ECI2/ETFA/ECH1/HADHB/ACADVL/ECHDC1 11 GO:0010469 regulation of signaling receptor activity 16/1165 173/18722 0.0730679061697274 0.224130239631153 PHLDA2/APP/NRP1/IFNGR2/NCF1/ITGB1/LRPAP1/AKAP9/VPS25/NCOA3/PARK7/LILRB4/HDAC2/SNX6/CGA/JAK2 16 GO:0003281 ventricular septum development 8/1165 71/18722 0.0730872064441953 0.224130239631153 LRP2/TGFBR3/GJA5/LMO4/GATA3/TBX3/SOX4/MDM2 8 GO:0032722 positive regulation of chemokine production 8/1165 71/18722 0.0730872064441953 0.224130239631153 APP/AIF1/CD74/PYCARD/OAS1/TLR2/SYK/LRP1 8 GO:0001845 phagolysosome assembly 3/1165 16/18722 0.0733524407985797 0.224130239631153 SYT7/MYO7A/CLN3 3 GO:0001977 renal system process involved in regulation of blood volume 3/1165 16/18722 0.0733524407985797 0.224130239631153 GJA5/GJA1/CYBA 3 GO:0002093 auditory receptor cell morphogenesis 3/1165 16/18722 0.0733524407985797 0.224130239631153 SOD1/MYO7A/TRIOBP 3 GO:0002371 dendritic cell cytokine production 3/1165 16/18722 0.0733524407985797 0.224130239631153 DHX36/DDX1/BST2 3 GO:0002713 negative regulation of B cell mediated immunity 3/1165 16/18722 0.0733524407985797 0.224130239631153 CD55/CD46/PTPN6 3 GO:0002890 negative regulation of immunoglobulin mediated immune response 3/1165 16/18722 0.0733524407985797 0.224130239631153 CD55/CD46/PTPN6 3 GO:0003084 positive regulation of systemic arterial blood pressure 3/1165 16/18722 0.0733524407985797 0.224130239631153 NR2F2/CYBA/RHOA 3 GO:0006004 fucose metabolic process 3/1165 16/18722 0.0733524407985797 0.224130239631153 FUT8/FUCA1/FUCA2 3 GO:0006555 methionine metabolic process 3/1165 16/18722 0.0733524407985797 0.224130239631153 SMS/ADI1/MTR 3 GO:0014819 regulation of skeletal muscle contraction 3/1165 16/18722 0.0733524407985797 0.224130239631153 GSTO1/C12orf57/NR4A1 3 GO:0021783 preganglionic parasympathetic fiber development 3/1165 16/18722 0.0733524407985797 0.224130239631153 NRP2/TFAP2A/NRP1 3 GO:0030033 microvillus assembly 3/1165 16/18722 0.0733524407985797 0.224130239631153 KLF5/FXYD5/STK26 3 GO:0032274 gonadotropin secretion 3/1165 16/18722 0.0733524407985797 0.224130239631153 GJA1/TBX3/CGA 3 GO:0033631 cell-cell adhesion mediated by integrin 3/1165 16/18722 0.0733524407985797 0.224130239631153 DPP4/PLPP3/ITGB1 3 GO:0035751 regulation of lysosomal lumen pH 3/1165 16/18722 0.0733524407985797 0.224130239631153 TMEM165/CLN3/GRN 3 GO:0043923 positive regulation by host of viral transcription 3/1165 16/18722 0.0733524407985797 0.224130239631153 TAF11/NUCKS1/JUN 3 GO:0050884 neuromuscular process controlling posture 3/1165 16/18722 0.0733524407985797 0.224130239631153 TMEM150C/PNKD/GCH1 3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 3/1165 16/18722 0.0733524407985797 0.224130239631153 APOE/ADAM8/TNFRSF1B 3 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 3/1165 16/18722 0.0733524407985797 0.224130239631153 STAT1/TLR2/JAK2 3 GO:0070242 thymocyte apoptotic process 3/1165 16/18722 0.0733524407985797 0.224130239631153 GLI3/EFNA1/ADAM8 3 GO:0072148 epithelial cell fate commitment 3/1165 16/18722 0.0733524407985797 0.224130239631153 NR2F2/ESRP1/NRP1 3 GO:0097284 hepatocyte apoptotic process 3/1165 16/18722 0.0733524407985797 0.224130239631153 KRT18/KRT8/DNMT3A 3 GO:1902570 protein localization to nucleolus 3/1165 16/18722 0.0733524407985797 0.224130239631153 NPM1/RAN/GLUL 3 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 3/1165 16/18722 0.0733524407985797 0.224130239631153 ZNRF3/GPC3/DAB2 3 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 3/1165 16/18722 0.0733524407985797 0.224130239631153 ANK3/SLC9A1/GLRX 3 GO:2001044 regulation of integrin-mediated signaling pathway 3/1165 16/18722 0.0733524407985797 0.224130239631153 TIMP1/FLNA/LIMS1 3 GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/1165 16/18722 0.0733524407985797 0.224130239631153 PLAUR/PARK7/JAK2 3 GO:0001704 formation of primary germ layer 12/1165 121/18722 0.0737265033366794 0.225028201864481 COL4A2/LAMB1/ITGB4/BMP7/WLS/GJA1/DUSP5/ITGB5/DUSP1/ITGB1/KLF4/RTF1 12 GO:0038127 ERBB signaling pathway 12/1165 121/18722 0.0737265033366794 0.225028201864481 EGFR/EFEMP1/NCF1/LGMN/IFI6/PLAUR/GRB2/PIK3C2A/TGFB1/VPS25/ARF4/SNX6 12 GO:0007411 axon guidance 20/1165 227/18722 0.0738639945175085 0.2253006381146 SEMA6A/LAMA5/SEMA6D/BMP7/DAG1/EPHB4/ISL1/APP/NRP2/GATA3/GLI3/EFNA1/NRP1/SIAH1/BSG/DLX5/VEGFA/VASP/RHOG/LRP1 20 GO:0006816 calcium ion transport 34/1165 422/18722 0.0738960404006733 0.2253006381146 GJA1/TMEM37/CXCR4/CYBA/TSPAN13/KCNN4/SLC9A1/ATP2B1/RHOA/PTPRC/C4orf3/LGALS3/AFG3L2/CAMK2G/PMPCB/ATP2B4/PTPN6/STOML2/GSTO1/LILRB2/ERO1A/VMP1/LILRB1/GNAI2/CXCL10/TMEM165/YWHAE/CCL4/CATSPER1/TSPO/SLC8A1/VDAC1/LILRA2/LYN 34 GO:1902652 secondary alcohol metabolic process 14/1165 147/18722 0.0740997679948942 0.225799130160337 LRP5/APP/SOD1/DHCR24/LIMA1/FDFT1/APOE/IDH1/FDPS/PMVK/FDX1/ACO2/ACADVL/APOBR 14 GO:0001562 response to protozoan 4/1165 26/18722 0.074850862014177 0.226245497299717 GBP2/GBP4/SLC11A1/HRAS 4 GO:0002026 regulation of the force of heart contraction 4/1165 26/18722 0.074850862014177 0.226245497299717 ADRB1/SLC9A1/ATP2B4/SLC8A1 4 GO:0002407 dendritic cell chemotaxis 4/1165 26/18722 0.074850862014177 0.226245497299717 CXCR4/C1QBP/SPI1/CALR 4 GO:0002418 immune response to tumor cell 4/1165 26/18722 0.074850862014177 0.226245497299717 HLA-A/HSPD1/HLA-DRB1/IL4I1 4 GO:0010875 positive regulation of cholesterol efflux 4/1165 26/18722 0.074850862014177 0.226245497299717 NFKBIA/APOE/TREM2/LRP1 4 GO:0014829 vascular associated smooth muscle contraction 4/1165 26/18722 0.074850862014177 0.226245497299717 ATP2B1/RHOA/PIK3C2A/SLC8A1 4 GO:0032682 negative regulation of chemokine production 4/1165 26/18722 0.074850862014177 0.226245497299717 GSTP1/KLF4/LILRB4/OAS1 4 GO:0033598 mammary gland epithelial cell proliferation 4/1165 26/18722 0.074850862014177 0.226245497299717 GATA3/CEBPB/GPX1/CCND1 4 GO:0043094 cellular metabolic compound salvage 4/1165 26/18722 0.074850862014177 0.226245497299717 ADI1/UPP1/ADK/PNP 4 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 4/1165 26/18722 0.074850862014177 0.226245497299717 SLC39A10/KCNN4/PTPRC/RPS3 4 GO:0051016 barbed-end actin filament capping 4/1165 26/18722 0.074850862014177 0.226245497299717 SCIN/EPS8/TRIOBP/ADD3 4 GO:0051560 mitochondrial calcium ion homeostasis 4/1165 26/18722 0.074850862014177 0.226245497299717 TGM2/AFG3L2/FIS1/BNIP3 4 GO:0060037 pharyngeal system development 4/1165 26/18722 0.074850862014177 0.226245497299717 BMP7/ISL1/FOLR1/GATA3 4 GO:0097205 renal filtration 4/1165 26/18722 0.074850862014177 0.226245497299717 GJA5/GJA1/CYBA/SULF2 4 GO:2000050 regulation of non-canonical Wnt signaling pathway 4/1165 26/18722 0.074850862014177 0.226245497299717 ZNRF3/GPC3/DAB2/RNF213 4 GO:0032409 regulation of transporter activity 26/1165 310/18722 0.0749379746313245 0.226386895374394 TCAF1/GJA1/FXYD3/CTSS/APP/TMSB4X/ANK3/IFNGR2/SLC9A1/NDFIP2/SLC5A3/KCNG1/ITGB1/DLG1/FXYD5/C4orf3/AKAP9/GSTO1/TREM2/PARK7/GLRX/VMP1/YWHAE/ACTB/UTRN/NDUFA4 26 GO:0002673 regulation of acute inflammatory response 6/1165 48/18722 0.0758401941356344 0.228252552109016 PTGES/HLA-E/GSTP1/IL6ST/PARK7/ADAM8 6 GO:0002715 regulation of natural killer cell mediated immunity 6/1165 48/18722 0.0758401941356344 0.228252552109016 HLA-B/HLA-A/CADM1/HLA-E/HLA-F/LILRB1 6 GO:0042149 cellular response to glucose starvation 6/1165 48/18722 0.0758401941356344 0.228252552109016 SLC2A1/SESN1/PMAIP1/HSPA5/UPP1/IFI16 6 GO:0043303 mast cell degranulation 6/1165 48/18722 0.0758401941356344 0.228252552109016 STXBP2/S100A13/FGR/SYK/CD300A/LYN 6 GO:0045839 negative regulation of mitotic nuclear division 6/1165 48/18722 0.0758401941356344 0.228252552109016 BMP7/DUSP1/AURKAIP1/CENPF/RAD21/CCNB1 6 GO:1903053 regulation of extracellular matrix organization 6/1165 48/18722 0.0758401941356344 0.228252552109016 DPP4/DAG1/CST3/TGFB1/LRP1/TNFRSF1B 6 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 6/1165 48/18722 0.0758401941356344 0.228252552109016 HSP90AB1/RPL23/RPL5/USP14/PARK7/RPS7 6 GO:0097485 neuron projection guidance 20/1165 228/18722 0.0764684873727113 0.230020160569683 SEMA6A/LAMA5/SEMA6D/BMP7/DAG1/EPHB4/ISL1/APP/NRP2/GATA3/GLI3/EFNA1/NRP1/SIAH1/BSG/DLX5/VEGFA/VASP/RHOG/LRP1 20 GO:0003012 muscle system process 36/1165 452/18722 0.0767287894786596 0.230679536873978 GJA5/DSP/DSG2/DAG1/GJA1/CALD1/CXCR4/ALDOA/PARP1/DSC2/SOD1/CYBA/TBX3/AIF1/SLC9A1/ATP2B1/DLG1/RHOA/ASPH/FLNA/CAMK2G/PIK3C2A/KLF4/ATP2B4/AKAP9/IL6ST/GSTO1/ENO1/HDAC2/C12orf57/SLC8A1/UTRN/SCO2/SULF2/TNFRSF1B/NR4A1 36 GO:0032508 DNA duplex unwinding 9/1165 84/18722 0.0768547674523792 0.23068759877551 MCM3/MCM6/MCM7/DHX36/DDX1/RUVBL1/RAD50/SSBP1/TOP2A 9 GO:0097061 dendritic spine organization 9/1165 84/18722 0.0768547674523792 0.23068759877551 IGF1R/EFNA1/APOE/LGMN/DHX36/TREM2/WASL/DOCK10/ABI3 9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 9/1165 84/18722 0.0768547674523792 0.23068759877551 CTDSPL/WEE1/DLG1/PRKDC/SOX4/CCND1/KLF4/BRD7/MDM2 9 GO:0006862 nucleotide transport 5/1165 37/18722 0.0773795602966767 0.231278986289094 GJA1/SLC19A1/SLC25A5/SLC25A36/SLC29A1 5 GO:0033120 positive regulation of RNA splicing 5/1165 37/18722 0.0773795602966767 0.231278986289094 PRDX6/NCL/RBM3/HSPA8/CIRBP 5 GO:0048846 axon extension involved in axon guidance 5/1165 37/18722 0.0773795602966767 0.231278986289094 SEMA6A/SEMA6D/NRP2/NRP1/VEGFA 5 GO:0090218 positive regulation of lipid kinase activity 5/1165 37/18722 0.0773795602966767 0.231278986289094 FLT1/VAV3/TGFB1/FGR/LYN 5 GO:1900016 negative regulation of cytokine production involved in inflammatory response 5/1165 37/18722 0.0773795602966767 0.231278986289094 PDCD4/PYCARD/TREM2/CHID1/LILRB4 5 GO:1902284 neuron projection extension involved in neuron projection guidance 5/1165 37/18722 0.0773795602966767 0.231278986289094 SEMA6A/SEMA6D/NRP2/NRP1/VEGFA 5 GO:1905332 positive regulation of morphogenesis of an epithelium 5/1165 37/18722 0.0773795602966767 0.231278986289094 MAGED1/LGR4/GJA1/GATA3/VEGFA 5 GO:0072329 monocarboxylic acid catabolic process 12/1165 122/18722 0.0773814245948544 0.231278986289094 SLC27A2/ECHDC2/ECHS1/PCCB/AIG1/ECI1/ECI2/ETFA/ECH1/HADHB/ACADVL/ECHDC1 12 GO:0009620 response to fungus 7/1165 60/18722 0.0778984195559157 0.23257650476987 GAPDH/COTL1/S100A8/CLEC4E/SPI1/S100A12/SYK 7 GO:0061951 establishment of protein localization to plasma membrane 7/1165 60/18722 0.0778984195559157 0.23257650476987 KRT18/NSG1/ANK3/VAMP5/GOLGA4/CLN3/RAB11A 7 GO:1903522 regulation of blood circulation 22/1165 256/18722 0.0781044636955229 0.233067705860165 EGFR/GJA5/DSP/DSG2/ADRB1/GJA1/ISL1/DSC2/EPAS1/SLC9A1/ATP2B1/DLG1/RHOA/FLNA/ATP2B4/AKAP9/MDM2/GSTO1/YWHAE/GCH1/SLC8A1/JAK2 22 GO:0006520 cellular amino acid metabolic process 24/1165 284/18722 0.0790442113196066 0.235746630253428 GLDC/GCSH/ASS1/SMS/IARS2/COMT/ECHS1/GCLM/CDO1/ADI1/GFPT1/RIMKLB/IL4I1/ASNSD1/MTR/ATP2B4/SLC1A3/PARK7/SLC25A13/KYNU/AASDHPPT/GLUL/CLN3/SLC7A7 24 GO:1901216 positive regulation of neuron death 10/1165 97/18722 0.0792158130302136 0.236132957269564 TYROBP/TFAP2A/PARP1/C1QA/FOS/RHOA/BAD/FIS1/JUN/GRN 10 GO:0007088 regulation of mitotic nuclear division 11/1165 110/18722 0.0805579548474668 0.240006263566258 BMP7/LRP5/OBSL1/DUSP1/AURKAIP1/ANAPC11/MKI67/CENPF/IGF2/RAD21/CCNB1 11 GO:0051592 response to calcium ion 14/1165 149/18722 0.0807902666184499 0.240570698424063 EGFR/SYT7/PTGES/DUSP1/LGMN/HSPA5/FOS/CCND1/FUS/JUNB/TXNIP/SLC25A13/BAD/PDCD6 14 GO:0002377 immunoglobulin production 19/1165 216/18722 0.0808428170815854 0.240599539914602 B2M/HSPD1/TFRC/HLA-E/HLA-DPA1/HLA-DRA/HLA-DRB1/PRKDC/HLA-DPB1/PTPRC/CD86/TGFB1/PHB/HLA-DMA/CTNNBL1/HLA-DQA1/GAPT/HLA-DQA2/HLA-DMB 19 GO:0051090 regulation of DNA-binding transcription factor activity 35/1165 440/18722 0.0810716929505242 0.241152841828984 BMP7/LRP5/APP/PRKCZ/TMSB4X/TFRC/ARID5B/ANXA3/PLPP3/PRDX2/NFKBIA/NPM1/ID1/S100A8/VEGFA/FLNA/SPI1/EIF2AK4/KLF4/CIB1/PYCARD/PRDX3/PARK7/TRIM22/HCK/HDAC2/PPIA/UFL1/S100A12/TLR2/LAMTOR5/RPS3/SYK/ADAM8/JAK2 35 GO:0006690 icosanoid metabolic process 12/1165 123/18722 0.0811495269707862 0.241256512122364 MGST3/ATP6V1B1/PTGES/MGLL/AKR1B1/GPX1/HPGD/GSTP1/CD74/GPX4/TLR2/SYK 12 GO:0030433 ubiquitin-dependent ERAD pathway 9/1165 85/18722 0.0814630602307436 0.242060432543761 HSP90B1/HSPA5/VCP/UBE4B/PSMC6/USP14/CCDC47/CALR/UBXN4 9 GO:0007517 muscle organ development 27/1165 327/18722 0.081756032627265 0.242686598319727 LRP2/LAMA5/NR2F2/TGFBR3/DSP/DAG1/ISL1/ASS1/ARID5B/GPC1/KLF5/VAMP5/GPX1/FOXO4/FOS/RHOA/EID2/SERP1/TGFB1/BASP1/GPCPD1/UQCC2/CENPF/IGF2/CXCL10/UTRN/NR4A1 27 GO:0002279 mast cell activation involved in immune response 6/1165 49/18722 0.0821061553909071 0.242686598319727 STXBP2/S100A13/FGR/SYK/CD300A/LYN 6 GO:0006692 prostanoid metabolic process 6/1165 49/18722 0.0821061553909071 0.242686598319727 ATP6V1B1/PTGES/AKR1B1/HPGD/GSTP1/CD74 6 GO:0006693 prostaglandin metabolic process 6/1165 49/18722 0.0821061553909071 0.242686598319727 ATP6V1B1/PTGES/AKR1B1/HPGD/GSTP1/CD74 6 GO:0018198 peptidyl-cysteine modification 6/1165 49/18722 0.0821061553909071 0.242686598319727 GAPDH/ADH5/S100A8/ATP2B4/PRDX3/PARK7 6 GO:0030857 negative regulation of epithelial cell differentiation 6/1165 49/18722 0.0821061553909071 0.242686598319727 TBX3/YAP1/STAT1/ID1/VEGFA/CCND1 6 GO:0046580 negative regulation of Ras protein signal transduction 6/1165 49/18722 0.0821061553909071 0.242686598319727 KANK1/MET/RASA1/ITGB1/FBP1/STMN1 6 GO:0050832 defense response to fungus 6/1165 49/18722 0.0821061553909071 0.242686598319727 GAPDH/COTL1/S100A8/CLEC4E/SPI1/S100A12 6 GO:0070741 response to interleukin-6 6/1165 49/18722 0.0821061553909071 0.242686598319727 YAP1/SPI1/IL6ST/JAK1/PHB/JAK2 6 GO:1904894 positive regulation of receptor signaling pathway via STAT 6/1165 49/18722 0.0821061553909071 0.242686598319727 PRLR/AKR1B1/TGFB1/IL10RB/CD300A/JAK2 6 GO:0042692 muscle cell differentiation 31/1165 384/18722 0.0830113611910641 0.244952997905958 ISL1/ERVW-1/KRT8/SOD2/OBSL1/CSRP2/TBX3/SLC9A1/KLF5/PDCD4/ITGB1/DNMT1/GPX1/FOXO4/VEGFA/MORF4L2/AFG3L2/CD9/TGFB1/MDM2/BHLHE41/GDF15/KRT19/PLEKHO1/CALR/IGF2/YBX1/CD53/CXCL10/SLC8A1/CCNB1 31 GO:0009166 nucleotide catabolic process 8/1165 73/18722 0.0830474888678135 0.244952997905958 TYMP/HINT1/NUDT4/VCP/UPP1/DNPH1/PNP/DUT 8 GO:0050848 regulation of calcium-mediated signaling 8/1165 73/18722 0.0830474888678135 0.244952997905958 SLC9A1/GBP1/ATP2B4/CIB1/TREM2/NFAT5/CCL4/SYK 8 GO:0099518 vesicle cytoskeletal trafficking 8/1165 73/18722 0.0830474888678135 0.244952997905958 PRKCZ/MYO7A/FNBP1L/CCDC186/MYO1G/WASL/CLN3/MYO1F 8 GO:0010976 positive regulation of neuron projection development 15/1165 163/18722 0.0833902085809106 0.245314349138901 TENM3/BMP7/ITGA6/SERPINF1/APOE/PTN/HSPA5/FLNA/DHX36/NME1/CREB3L2/SNX3/LRP1/GRN/LYN 15 GO:0006900 vesicle budding from membrane 7/1165 61/18722 0.0835199615897821 0.245314349138901 S100A10/FNBP1L/TFG/TMED9/WASL/SNX3/PDCD6 7 GO:0090342 regulation of cell aging 7/1165 61/18722 0.0835199615897821 0.245314349138901 B2M/CDK6/PAWR/PRKDC/YBX1/ABI3/YPEL3 7 GO:0000027 ribosomal large subunit assembly 4/1165 27/18722 0.0837381601550212 0.245314349138901 RPLP0/MRPL20/RPL5/BRIX1 4 GO:0003171 atrioventricular valve development 4/1165 27/18722 0.0837381601550212 0.245314349138901 GJA5/EFNA1/SOX4/MDM2 4 GO:0010586 miRNA metabolic process 4/1165 27/18722 0.0837381601550212 0.245314349138901 LIN28B/KCNQ1OT1/HRAS/SND1 4 GO:0015813 L-glutamate transmembrane transport 4/1165 27/18722 0.0837381601550212 0.245314349138901 ITGB1/ARL6IP5/SLC1A3/SLC25A13 4 GO:0032967 positive regulation of collagen biosynthetic process 4/1165 27/18722 0.0837381601550212 0.245314349138901 VIM/TGFB1/HDAC2/SUCO 4 GO:0033561 regulation of water loss via skin 4/1165 27/18722 0.0837381601550212 0.245314349138901 MET/CLDN4/LSR/STMN1 4 GO:0042104 positive regulation of activated T cell proliferation 4/1165 27/18722 0.0837381601550212 0.245314349138901 CD24/PYCARD/IGF2/RPS3 4 GO:0042402 cellular biogenic amine catabolic process 4/1165 27/18722 0.0837381601550212 0.245314349138901 ALDH7A1/COMT/IL4I1/KYNU 4 GO:1903205 regulation of hydrogen peroxide-induced cell death 4/1165 27/18722 0.0837381601550212 0.245314349138901 MET/PAWR/STK26/PARK7 4 GO:1903319 positive regulation of protein maturation 4/1165 27/18722 0.0837381601550212 0.245314349138901 BAG2/SOX4/ENO1/ADAM8 4 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 5/1165 38/18722 0.084766448873399 0.246625595960809 ISL1/DAB2/RHOA/CALR/PHB 5 GO:0042596 fear response 5/1165 38/18722 0.084766448873399 0.246625595960809 DPP4/ADRB1/GJA1/APOE/VDAC1 5 GO:1903580 positive regulation of ATP metabolic process 5/1165 38/18722 0.084766448873399 0.246625595960809 APP/TMSB4X/VCP/TREM2/ENO1 5 GO:0000097 sulfur amino acid biosynthetic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 CDO1/ADI1/MTR 3 GO:0006901 vesicle coating 3/1165 17/18722 0.0851084588234609 0.246625595960809 TFG/TMED9/PDCD6 3 GO:0009084 glutamine family amino acid biosynthetic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 ASS1/GLUL/CLN3 3 GO:0009151 purine deoxyribonucleotide metabolic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 ADK/DNPH1/PNP 3 GO:0009200 deoxyribonucleoside triphosphate metabolic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 ADK/TYMS/DUT 3 GO:0010224 response to UV-B 3/1165 17/18722 0.0851084588234609 0.246625595960809 MME/CRIP1/HMGN1 3 GO:0021924 cell proliferation in external granule layer 3/1165 17/18722 0.0851084588234609 0.246625595960809 SLC6A4/ATF5/PSMG1 3 GO:0021930 cerebellar granule cell precursor proliferation 3/1165 17/18722 0.0851084588234609 0.246625595960809 SLC6A4/ATF5/PSMG1 3 GO:0032604 granulocyte macrophage colony-stimulating factor production 3/1165 17/18722 0.0851084588234609 0.246625595960809 ISL1/SYK/LILRA2 3 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 3/1165 17/18722 0.0851084588234609 0.246625595960809 ISL1/SYK/LILRA2 3 GO:0033623 regulation of integrin activation 3/1165 17/18722 0.0851084588234609 0.246625595960809 FERMT1/JAM3/FERMT2 3 GO:0035729 cellular response to hepatocyte growth factor stimulus 3/1165 17/18722 0.0851084588234609 0.246625595960809 NRP1/GCLM/LGMN 3 GO:0036035 osteoclast development 3/1165 17/18722 0.0851084588234609 0.246625595960809 FBN1/TYROBP/LILRB1 3 GO:0042053 regulation of dopamine metabolic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 COMT/PNKD/PARK7 3 GO:0042069 regulation of catecholamine metabolic process 3/1165 17/18722 0.0851084588234609 0.246625595960809 COMT/PNKD/PARK7 3 GO:0043968 histone H2A acetylation 3/1165 17/18722 0.0851084588234609 0.246625595960809 MORF4L2/RUVBL1/MORF4L1 3 GO:0060033 anatomical structure regression 3/1165 17/18722 0.0851084588234609 0.246625595960809 LRP5/FLT1/SPI1 3 GO:0061158 3'-UTR-mediated mRNA destabilization 3/1165 17/18722 0.0851084588234609 0.246625595960809 ZFP36/DHX36/ZFP36L1 3 GO:0098739 import across plasma membrane 16/1165 177/18722 0.0855022509943183 0.247638872461872 LRP2/SLC2A1/FOLR1/SLC19A1/SLC39A10/SLC9A1/SLC5A3/ITGB1/DLG1/SLC5A6/ATP2B4/ARL6IP5/SLC1A3/SLC2A3/ISCU/SLC8A1 16 GO:0014031 mesenchymal cell development 9/1165 86/18722 0.0862345998192734 0.249631154608345 SEMA6A/LAMA5/SEMA6D/BMP7/ISL1/NRP2/FOLR1/NRP1/PDCD6 9 GO:0050803 regulation of synapse structure or activity 19/1165 218/18722 0.0866218159525276 0.250622810794607 SRGN/DAG1/DLG5/APP/NRP2/EFNA1/APOE/PTN/TUBB/VCP/RHOA/DHX36/TREM2/LILRB2/ARF4/TLR2/CLN3/ABI3/HSPA8 19 GO:0006165 nucleoside diphosphate phosphorylation 10/1165 99/18722 0.088053187482504 0.254501823552675 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/PGK1/PKM/ENO1/NME1 10 GO:0060291 long-term synaptic potentiation 10/1165 99/18722 0.088053187482504 0.254501823552675 MME/NSG1/TYROBP/APP/PRKCZ/APOE/PTN/LGMN/EIF2AK4/LILRB2 10 GO:0003007 heart morphogenesis 21/1165 246/18722 0.0881533520046927 0.254660198045466 LRP2/TGFBR3/GJA5/ADAMTS1/DSP/BMP7/EPHB4/ISL1/NRP2/FOLR1/GATA3/TBX3/EFNA1/YAP1/NRP1/PDCD4/VEGFA/SOX4/FLNA/TGFB1/MDM2 21 GO:0051091 positive regulation of DNA-binding transcription factor activity 22/1165 260/18722 0.08861699836502 0.255309552699075 LRP5/APP/PRKCZ/TFRC/ARID5B/ANXA3/PLPP3/NPM1/S100A8/VEGFA/CIB1/PYCARD/PRDX3/PARK7/TRIM22/PPIA/S100A12/TLR2/LAMTOR5/RPS3/ADAM8/JAK2 22 GO:0001961 positive regulation of cytokine-mediated signaling pathway 6/1165 50/18722 0.088651045467753 0.255309552699075 CXCR4/LAPTM5/CD74/TREM2/IRF7/PARP9 6 GO:0002448 mast cell mediated immunity 6/1165 50/18722 0.088651045467753 0.255309552699075 STXBP2/S100A13/FGR/SYK/CD300A/LYN 6 GO:0002639 positive regulation of immunoglobulin production 6/1165 50/18722 0.088651045467753 0.255309552699075 TFRC/HLA-E/PTPRC/CD86/TGFB1/PHB 6 GO:0006220 pyrimidine nucleotide metabolic process 6/1165 50/18722 0.088651045467753 0.255309552699075 TYMP/UPP1/AK3/TYMS/NME1/DUT 6 GO:0070231 T cell apoptotic process 6/1165 50/18722 0.088651045467753 0.255309552699075 GLI3/EFNA1/LGALS3/TSC22D3/KDELR1/ADAM8 6 GO:0070585 protein localization to mitochondrion 12/1165 125/18722 0.0890266087535774 0.256259669196836 ISG15/HSPD1/LMAN1/BNIP3L/HSP90AA1/PMPCB/TIMM13/NMT1/ROMO1/FIS1/TSPO/TIMM8B 12 GO:0032835 glomerulus development 7/1165 62/18722 0.0893678649598097 0.257110110722405 BMP7/ENPEP/LGR4/CD24/PECAM1/BASP1/SULF2 7 GO:0034764 positive regulation of transmembrane transport 19/1165 219/18722 0.0896097873154154 0.257674045185157 TCAF1/CTSS/SORBS1/TMSB4X/ANK3/GPC3/KCNN4/IFNGR2/SLC9A1/ITGB1/FLNA/AKAP9/OPN3/GSTO1/TREM2/GLRX/VMP1/CXCL10/NDUFA4 19 GO:0001776 leukocyte homeostasis 9/1165 87/18722 0.0911691901852075 0.2620238937581 JAM3/PMAIP1/SKIL/CD74/TNFSF13B/TSC22D3/DOCK10/GAPT/LYN 9 GO:0016125 sterol metabolic process 14/1165 152/18722 0.0915310890343746 0.262794886317107 LRP5/APP/SOD1/DHCR24/LIMA1/FDFT1/APOE/FDPS/PMVK/CYB5R1/FDX1/LIPA/ACADVL/APOBR 14 GO:0030509 BMP signaling pathway 14/1165 152/18722 0.0915310890343746 0.262794886317107 FBN1/LRP2/CRIM1/TGFBR3/BMP7/FSTL1/GPC3/PDCD4/DLX5/HTRA1/SKIL/TGFB1/GDF15/SORL1 14 GO:0010463 mesenchymal cell proliferation 5/1165 39/18722 0.0925098117789084 0.265469107114015 BMP7/LRP5/GPC3/PTN/STAT1 5 GO:0006626 protein targeting to mitochondrion 10/1165 100/18722 0.0926859325229547 0.265567197167608 HSPD1/LMAN1/BNIP3L/HSP90AA1/PMPCB/TIMM13/ROMO1/FIS1/TSPO/TIMM8B 10 GO:0044728 DNA methylation or demethylation 10/1165 100/18722 0.0926859325229547 0.265567197167608 GATA3/PARP1/APOBEC3A/HELLS/DNMT1/FOS/DNMT3A/SPI1/APEX1/MBD2 10 GO:0110020 regulation of actomyosin structure organization 10/1165 100/18722 0.0926859325229547 0.265567197167608 MET/TACSTD2/TJP1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/WASF2/STMN1 10 GO:0002675 positive regulation of acute inflammatory response 4/1165 28/18722 0.0931154600374365 0.265577783125067 HLA-E/IL6ST/PARK7/ADAM8 4 GO:0010575 positive regulation of vascular endothelial growth factor production 4/1165 28/18722 0.0931154600374365 0.265577783125067 ISL1/IL6ST/TGFB1/SULF2 4 GO:0010714 positive regulation of collagen metabolic process 4/1165 28/18722 0.0931154600374365 0.265577783125067 VIM/TGFB1/HDAC2/SUCO 4 GO:0032607 interferon-alpha production 4/1165 28/18722 0.0931154600374365 0.265577783125067 HSPD1/STAT1/DHX36/IRF7 4 GO:0032647 regulation of interferon-alpha production 4/1165 28/18722 0.0931154600374365 0.265577783125067 HSPD1/STAT1/DHX36/IRF7 4 GO:0045671 negative regulation of osteoclast differentiation 4/1165 28/18722 0.0931154600374365 0.265577783125067 FBN1/LILRB4/LILRB1/LILRB3 4 GO:0051503 adenine nucleotide transport 4/1165 28/18722 0.0931154600374365 0.265577783125067 GJA1/SLC19A1/SLC25A5/SLC29A1 4 GO:1903649 regulation of cytoplasmic transport 4/1165 28/18722 0.0931154600374365 0.265577783125067 DAB2/MSN/SNX3/SORL1 4 GO:1903779 regulation of cardiac conduction 4/1165 28/18722 0.0931154600374365 0.265577783125067 GJA5/ATP2B1/ATP2B4/SLC8A1 4 GO:0002292 T cell differentiation involved in immune response 8/1165 75/18722 0.0937674895556249 0.26710968554223 GATA3/PRKCZ/FCER1G/HLA-DRA/FGL2/HLA-DRB1/CD86/CD46 8 GO:1903363 negative regulation of cellular protein catabolic process 8/1165 75/18722 0.0937674895556249 0.26710968554223 HSP90AB1/EFNA1/RPL23/RPL5/USP14/PARK7/RPS7/ATRAID 8 GO:0030307 positive regulation of cell growth 15/1165 166/18722 0.0938429182058217 0.26710968554223 EGFR/CXCR4/CYBA/NRP1/SLC9A1/GOLGA4/S100A8/RHOA/VEGFA/CIB1/USP47/CXCL16/DNPH1/RAB11A/LRP1 15 GO:0060538 skeletal muscle organ development 15/1165 166/18722 0.0938429182058217 0.26710968554223 NR2F2/DAG1/ASS1/GPC1/KLF5/VAMP5/GPX1/FOS/RHOA/TGFB1/BASP1/GPCPD1/UQCC2/IGF2/NR4A1 15 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 6/1165 51/18722 0.0954717550219162 0.271333144778742 STAT1/RHOA/GSTP1/PYCARD/TREM2/LILRB4 6 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 6/1165 51/18722 0.0954717550219162 0.271333144778742 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86/CD83 6 GO:0046850 regulation of bone remodeling 6/1165 51/18722 0.0954717550219162 0.271333144778742 EGFR/SYT7/TFRC/SUCO/SYK/ADAM8 6 GO:0001843 neural tube closure 9/1165 88/18722 0.0962663758509016 0.273453020066351 LRP2/SPINT1/SPINT2/FOLR1/LMO4/PRKACB/TGFB1/RPS7/VASP 9 GO:0051656 establishment of organelle localization 31/1165 390/18722 0.0964873092946265 0.273516077537324 SYNE2/GJA1/PRKCZ/STXBP2/MYO7A/NPM1/ITGB1/FNBP1L/DLG1/S100A13/AP1M2/UBB/ARMCX3/TFG/TMED9/RAN/LRPPRC/CCDC186/CENPF/MYO1G/WASL/PCM1/FGR/CLN3/RAB11A/PDCD6/SYK/MYO1F/CD300A/CCNB1/LYN 31 GO:0046939 nucleotide phosphorylation 10/1165 101/18722 0.0974611043698871 0.273516077537324 LDHA/APP/ALDOA/GAPDH/FBP1/TPI1/PGK1/PKM/ENO1/NME1 10 GO:0050830 defense response to Gram-positive bacterium 10/1165 101/18722 0.0974611043698871 0.273516077537324 LYZ/HLA-A/HLA-E/GBP2/GBP4/PYCARD/FGR/TLR2/ROMO1/DEFB1 10 GO:0002223 stimulatory C-type lectin receptor signaling pathway 3/1165 18/18722 0.0976042585617782 0.273516077537324 TYROBP/SYK/LYN 3 GO:0002544 chronic inflammatory response 3/1165 18/18722 0.0976042585617782 0.273516077537324 GJA1/PTGES/S100A8 3 GO:0002643 regulation of tolerance induction 3/1165 18/18722 0.0976042585617782 0.273516077537324 HLA-B/LILRB2/LILRB4 3 GO:0006085 acetyl-CoA biosynthetic process 3/1165 18/18722 0.0976042585617782 0.273516077537324 ACSS1/MPC2/DLD 3 GO:0006595 polyamine metabolic process 3/1165 18/18722 0.0976042585617782 0.273516077537324 SMS/OAZ1/SRM 3 GO:0010985 negative regulation of lipoprotein particle clearance 3/1165 18/18722 0.0976042585617782 0.273516077537324 LRPAP1/MYLIP/APOC1 3 GO:0021534 cell proliferation in hindbrain 3/1165 18/18722 0.0976042585617782 0.273516077537324 SLC6A4/ATF5/PSMG1 3 GO:0032634 interleukin-5 production 3/1165 18/18722 0.0976042585617782 0.273516077537324 GATA3/PRKCZ/LILRB4 3 GO:0032674 regulation of interleukin-5 production 3/1165 18/18722 0.0976042585617782 0.273516077537324 GATA3/PRKCZ/LILRB4 3 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 3/1165 18/18722 0.0976042585617782 0.273516077537324 GATA3/PRKCZ/RSAD2 3 GO:0043217 myelin maintenance 3/1165 18/18722 0.0976042585617782 0.273516077537324 CXCR4/SOD1/DEGS1 3 GO:0045116 protein neddylation 3/1165 18/18722 0.0976042585617782 0.273516077537324 EPAS1/RPL5/NEDD8 3 GO:0046040 IMP metabolic process 3/1165 18/18722 0.0976042585617782 0.273516077537324 PAICS/ATIC/PNP 3 GO:0048486 parasympathetic nervous system development 3/1165 18/18722 0.0976042585617782 0.273516077537324 NRP2/TFAP2A/NRP1 3 GO:0050665 hydrogen peroxide biosynthetic process 3/1165 18/18722 0.0976042585617782 0.273516077537324 SOD2/SOD1/CYBA 3 GO:0051782 negative regulation of cell division 3/1165 18/18722 0.0976042585617782 0.273516077537324 ASPM/ORC6/TXNIP 3 GO:0061484 hematopoietic stem cell homeostasis 3/1165 18/18722 0.0976042585617782 0.273516077537324 ADGRG1/FSTL1/SOX4 3 GO:0072234 metanephric nephron tubule development 3/1165 18/18722 0.0976042585617782 0.273516077537324 LGR4/YAP1/STAT1 3 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 3/1165 18/18722 0.0976042585617782 0.273516077537324 MAGED1/LGR4/VEGFA 3 GO:1903209 positive regulation of oxidative stress-induced cell death 3/1165 18/18722 0.0976042585617782 0.273516077537324 SOD1/PAWR/PARK7 3 GO:1904872 regulation of telomerase RNA localization to Cajal body 3/1165 18/18722 0.0976042585617782 0.273516077537324 CCT2/RUVBL1/NHP2 3 GO:1990840 response to lectin 3/1165 18/18722 0.0976042585617782 0.273516077537324 TYROBP/SYK/LYN 3 GO:1990858 cellular response to lectin 3/1165 18/18722 0.0976042585617782 0.273516077537324 TYROBP/SYK/LYN 3 GO:2000641 regulation of early endosome to late endosome transport 3/1165 18/18722 0.0976042585617782 0.273516077537324 DAB2/MSN/SNX3 3 GO:0007605 sensory perception of sound 14/1165 154/18722 0.0991643123952578 0.277610616196799 LRP2/USP53/ALDH7A1/ATP6V1B1/TFAP2A/SOD1/MYO7A/TBL1X/GPX1/TIMM13/SLC1A3/TRIOBP/NDUFB9/TIMM8B 14 GO:0030856 regulation of epithelial cell differentiation 14/1165 154/18722 0.0991643123952578 0.277610616196799 ESRP1/GATA3/CD24/TBX3/YAP1/ZFP36/STAT1/ID1/CEBPB/VEGFA/CCND1/NCOA3/BAD/ZFP36L1 14 GO:0009416 response to light stimulus 26/1165 320/18722 0.099307943851971 0.277874122054393 EGFR/MME/APP/TIMP1/PARP1/NR2F6/DDB1/DUSP1/NPM1/ITGB1/PTN/GPX1/GNA11/FOS/DHX36/UBE4B/EIF2AK4/CRIP1/CCND1/SLC1A3/MDM2/OPN3/NMT1/USP47/HMGN1/CIRBP 26 GO:0090068 positive regulation of cell cycle process 20/1165 236/18722 0.0995191710041093 0.278326410984587 EGFR/PBX1/ADAMTS1/LRP5/APP/AIF1/BRD4/CCND3/NPM1/RHOA/PLSCR1/CCND1/ANAPC11/MDM2/RANBP1/IGF2/RAD21/APEX1/RAB11A/CCNB1 20 GO:0030183 B cell differentiation 13/1165 141/18722 0.100592693025099 0.279960997502884 ITGB1/PRKDC/PTPRC/SLC25A5/IL4I1/SPI1/PTPN6/TNFSF13B/KLF6/BAD/DOCK10/ZFP36L1/SYK 13 GO:0002714 positive regulation of B cell mediated immunity 5/1165 40/18722 0.100602410825462 0.279960997502884 TFRC/HLA-E/PTPRC/TGFB1/TREM2 5 GO:0002891 positive regulation of immunoglobulin mediated immune response 5/1165 40/18722 0.100602410825462 0.279960997502884 TFRC/HLA-E/PTPRC/TGFB1/TREM2 5 GO:0014037 Schwann cell differentiation 5/1165 40/18722 0.100602410825462 0.279960997502884 ITGB4/DAG1/SOD1/GPC1/ERBB3 5 GO:0034122 negative regulation of toll-like receptor signaling pathway 5/1165 40/18722 0.100602410825462 0.279960997502884 LGR4/TREM2/CD300A/LILRA2/LYN 5 GO:0035329 hippo signaling 5/1165 40/18722 0.100602410825462 0.279960997502884 DLG5/TEAD1/AMOT/YAP1/LATS2 5 GO:0043001 Golgi to plasma membrane protein transport 5/1165 40/18722 0.100602410825462 0.279960997502884 KRT18/ANK3/VAMP5/GOLGA4/CLN3 5 GO:0045740 positive regulation of DNA replication 5/1165 40/18722 0.100602410825462 0.279960997502884 EGFR/STOML2/HRAS/SSBP1/JUN 5 GO:0045777 positive regulation of blood pressure 5/1165 40/18722 0.100602410825462 0.279960997502884 NR2F2/ADRB1/CYBA/ADH5/RHOA 5 GO:0046365 monosaccharide catabolic process 5/1165 40/18722 0.100602410825462 0.279960997502884 LRP5/FUT8/ENO1/BAD/NUDT5 5 GO:0060606 tube closure 9/1165 89/18722 0.101525443800429 0.282389651165416 LRP2/SPINT1/SPINT2/FOLR1/LMO4/PRKACB/TGFB1/RPS7/VASP 9 GO:0016126 sterol biosynthetic process 7/1165 64/18722 0.101735890836682 0.282694829339751 SOD1/DHCR24/FDFT1/APOE/FDPS/PMVK/CYB5R1 7 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 7/1165 64/18722 0.101735890836682 0.282694829339751 HSP90AB1/EFNA1/RPL23/RPL5/USP14/PARK7/RPS7 7 GO:0046916 cellular transition metal ion homeostasis 11/1165 115/18722 0.102350133721629 0.284198374493377 FTH1/SLC40A1/APP/SLC39A10/TFRC/SOD1/S100A8/SLC11A1/SLC39A7/ISCU/SCO2 11 GO:0035710 CD4-positive, alpha-beta T cell activation 10/1165 102/18722 0.102378249283023 0.284198374493377 CTSL/GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD55/CD86/STOML2/RSAD2/CD83 10 GO:0010718 positive regulation of epithelial to mesenchymal transition 6/1165 52/18722 0.102564430190496 0.284282763147811 BMP7/ISL1/FERMT2/DAB2/TGFB1/HDAC2 6 GO:0030514 negative regulation of BMP signaling pathway 6/1165 52/18722 0.102564430190496 0.284282763147811 FBN1/LRP2/CRIM1/HTRA1/SKIL/SORL1 6 GO:0015868 purine ribonucleotide transport 4/1165 29/18722 0.102965768302067 0.284282763147811 GJA1/SLC19A1/SLC25A5/SLC29A1 4 GO:0019082 viral protein processing 4/1165 29/18722 0.102965768302067 0.284282763147811 FUT8/ST3GAL4/MGAT1/PARP9 4 GO:0021522 spinal cord motor neuron differentiation 4/1165 29/18722 0.102965768302067 0.284282763147811 ISL1/LMO4/GLI3/SOX4 4 GO:0021591 ventricular system development 4/1165 29/18722 0.102965768302067 0.284282763147811 SEMA6D/CDK6/CENPF/C12orf57 4 GO:0021602 cranial nerve morphogenesis 4/1165 29/18722 0.102965768302067 0.284282763147811 NRP2/TFAP2A/GLI3/NRP1 4 GO:0034067 protein localization to Golgi apparatus 4/1165 29/18722 0.102965768302067 0.284282763147811 OBSL1/GBP5/ARL1/SORL1 4 GO:0048265 response to pain 4/1165 29/18722 0.102965768302067 0.284282763147811 VWA1/COMT/GCH1/TSPO 4 GO:0060441 epithelial tube branching involved in lung morphogenesis 4/1165 29/18722 0.102965768302067 0.284282763147811 DAG1/DLG5/YAP1/CTSH 4 GO:1903902 positive regulation of viral life cycle 4/1165 29/18722 0.102965768302067 0.284282763147811 DDB1/P4HB/HLA-DRB1/CD74 4 GO:0006606 protein import into nucleus 14/1165 155/18722 0.103122906613522 0.28457663462227 CDH1/FERMT1/GLI3/HSP90AB1/RPL23/NFKBIA/FLNA/RAN/TGFB1/TXNIP/TNPO1/SYK/JAK2/NUP214 14 GO:0090276 regulation of peptide hormone secretion 17/1165 196/18722 0.104063693052242 0.287031699804539 EGFR/DPP4/LRP5/GJA1/ISL1/SYT7/MPC2/HLA-DRB1/HMGN3/SOX4/SERP1/UQCC2/BAD/GLUL/LRP1/JAK2/ENSA 17 GO:0043010 camera-type eye development 26/1165 322/18722 0.104735934526267 0.288744008102131 FBN1/TENM3/FBN2/EFEMP1/BMP7/LRP5/SERPINF1/GATA3/TFAP2A/GLI3/OBSL1/FLT1/NRP1/PTN/ATP2B1/DLG1/VEGFA/VIM/SKIL/PFDN5/KLF4/ATP2B4/HDAC2/C12orf57/IMPDH2/HMGN1 26 GO:0006937 regulation of muscle contraction 15/1165 169/18722 0.105080182614484 0.289408765954415 GJA5/DSP/DSG2/DSC2/SOD1/SLC9A1/ATP2B1/DLG1/RHOA/AKAP9/GSTO1/ENO1/C12orf57/SLC8A1/NR4A1 15 GO:0018394 peptidyl-lysine acetylation 15/1165 169/18722 0.105080182614484 0.289408765954415 ISL1/GATA3/MORF4L2/SOX4/HINT2/SPI1/USP22/RUVBL1/BRD7/NCOA3/PARK7/HDAC2/MORF4L1/SET/PHF20 15 GO:0007492 endoderm development 8/1165 77/18722 0.105240024957391 0.289706846535475 COL4A2/LAMB1/LAMC1/DUSP5/ITGB5/DUSP1/RTF1/ZFP36L1 8 GO:0030901 midbrain development 9/1165 90/18722 0.106945426149081 0.29392805110709 WLS/DLG5/UQCRQ/HSPA5/RHOA/BASP1/YWHAE/ACTB/NDUFS3 9 GO:0061097 regulation of protein tyrosine kinase activity 9/1165 90/18722 0.106945426149081 0.29392805110709 APP/ERBB3/CD24/EFNA1/NCF1/PTPRC/VPS25/LILRB4/SNX6 9 GO:0099175 regulation of postsynapse organization 9/1165 90/18722 0.106945426149081 0.29392805110709 SRGN/NRP2/EFNA1/APOE/DHX36/LILRB2/ARF4/ABI3/HSPA8 9 GO:0030326 embryonic limb morphogenesis 11/1165 116/18722 0.107087629523249 0.29392805110709 FBN2/PBX1/BMP7/LRP5/FRAS1/TFAP2A/GLI3/GPC3/TBX3/DLX5/HDAC2 11 GO:0030518 intracellular steroid hormone receptor signaling pathway 11/1165 116/18722 0.107087629523249 0.29392805110709 ISL1/PARP1/YAP1/SKP2/DAB2/RHOA/PARK7/CALR/PHB/UFL1/JAK2 11 GO:0035113 embryonic appendage morphogenesis 11/1165 116/18722 0.107087629523249 0.29392805110709 FBN2/PBX1/BMP7/LRP5/FRAS1/TFAP2A/GLI3/GPC3/TBX3/DLX5/HDAC2 11 GO:0009267 cellular response to starvation 14/1165 156/18722 0.107176041139004 0.294026939840288 CTSV/SLC2A1/COMT/SESN1/PMAIP1/HSPA5/UPP1/EIF2AK4/STK26/GLUL/IFI16/HSPA8/JUN/GABARAPL1 14 GO:0042594 response to starvation 17/1165 197/18722 0.107662003879298 0.295215841609428 CTSV/PAGE4/SLC2A1/COMT/ZFP36/SESN1/PMAIP1/HSPA5/UPP1/EIF2AK1/EIF2AK4/STK26/GLUL/IFI16/HSPA8/JUN/GABARAPL1 17 GO:0003170 heart valve development 7/1165 65/18722 0.108251349962598 0.296252963110708 GJA5/GATA3/EFNA1/SOX4/TGFB1/MDM2/TNFRSF1B 7 GO:0043489 RNA stabilization 7/1165 65/18722 0.108251349962598 0.296252963110708 ZFP36/DHX36/FUS/SLC11A1/PABPC1/YBX1/CIRBP 7 GO:0060389 pathway-restricted SMAD protein phosphorylation 7/1165 65/18722 0.108251349962598 0.296252963110708 TGFBR3/BMP7/RBPMS/DAB2/TGFB1/GDF15/LRP1 7 GO:1902475 L-alpha-amino acid transmembrane transport 7/1165 65/18722 0.108251349962598 0.296252963110708 SLC38A1/SLC38A9/ITGB1/ARL6IP5/SLC1A3/SLC25A13/SLC7A7 7 GO:0030100 regulation of endocytosis 18/1165 211/18722 0.108431568460838 0.296601556418462 B2M/AAK1/GPC3/APOE/DAB2/CD14/LRPAP1/VEGFA/LGALS3/APOC1/TREM2/WASL/LILRB1/CLN3/CD2AP/SYK/LRP1/CD300A 18 GO:0030178 negative regulation of Wnt signaling pathway 15/1165 170/18722 0.109000355022229 0.297674293059624 FERMT1/RNF43/ISL1/ZNRF3/GLI3/NOTUM/GPC3/APOE/DAB2/SIAH2/LATS2/PFDN5/RNF213/TLE4/LRP1 15 GO:0043487 regulation of RNA stability 15/1165 170/18722 0.109000355022229 0.297674293059624 LIN28B/NPM1/ZFP36/VIM/DHX36/FUS/SLC11A1/SERBP1/CARHSP1/PABPC1/YBX1/APEX1/ZFP36L1/CIRBP/TNFRSF1B 15 GO:1900371 regulation of purine nucleotide biosynthetic process 5/1165 41/18722 0.109035871464562 0.297674293059624 TMSB4X/PARP1/VCP/TREM2/ENO1 5 GO:1905314 semi-lunar valve development 5/1165 41/18722 0.109035871464562 0.297674293059624 GJA5/GATA3/EFNA1/TGFB1/TNFRSF1B 5 GO:0016049 cell growth 37/1165 482/18722 0.10915506876531 0.297854837617738 SEMA6A/EGFR/SEMA6D/GJA1/CXCR4/APP/NRP2/PRKCZ/CYBA/HSP90AB1/RBBP7/NRP1/SLC9A1/NET1/EI24/NPM1/APOE/HSP90AA1/ITGB1/FBP1/GOLGA4/SMARCA2/S100A8/RHOA/VEGFA/EIF2AK4/CIB1/TGFB1/ENO1/USP47/PHB/CXCL16/BST2/DNPH1/RAB11A/NDUFS3/LRP1 37 GO:0051438 regulation of ubiquitin-protein transferase activity 6/1165 53/18722 0.109924504280919 0.29796688089979 RPL23/BAG2/RPL5/RPL37/PARK7/RPS7 6 GO:1903202 negative regulation of oxidative stress-induced cell death 6/1165 53/18722 0.109924504280919 0.29796688089979 MET/PAGE4/SOD2/GPX1/PARK7/PPIA 6 GO:0006956 complement activation 12/1165 130/18722 0.11071052789585 0.29796688089979 FCN1/CD59/C1QA/C1QB/C1QC/C1QBP/CD55/A2M/CD46/TREM2/PHB/CFP 12 GO:0002902 regulation of B cell apoptotic process 3/1165 19/18722 0.110788683491513 0.29796688089979 SLC39A10/CD74/LYN 3 GO:0006007 glucose catabolic process 3/1165 19/18722 0.110788683491513 0.29796688089979 LRP5/ENO1/BAD 3 GO:0006071 glycerol metabolic process 3/1165 19/18722 0.110788683491513 0.29796688089979 TPI1/PGP/GK 3 GO:0006491 N-glycan processing 3/1165 19/18722 0.110788683491513 0.29796688089979 FUT8/MAN1A2/GANAB 3 GO:0007039 protein catabolic process in the vacuole 3/1165 19/18722 0.110788683491513 0.29796688089979 LRP2/CLN3/LRP1 3 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 3/1165 19/18722 0.110788683491513 0.29796688089979 GNA11/RGS10/GNAI2 3 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 3/1165 19/18722 0.110788683491513 0.29796688089979 TYMP/UPP1/DUT 3 GO:0030220 platelet formation 3/1165 19/18722 0.110788683491513 0.29796688089979 PRKDC/CIB1/PTPN6 3 GO:0031290 retinal ganglion cell axon guidance 3/1165 19/18722 0.110788683491513 0.29796688089979 ISL1/NRP1/VEGFA 3 GO:0032616 interleukin-13 production 3/1165 19/18722 0.110788683491513 0.29796688089979 GATA3/PRKCZ/HLA-E 3 GO:0032656 regulation of interleukin-13 production 3/1165 19/18722 0.110788683491513 0.29796688089979 GATA3/PRKCZ/HLA-E 3 GO:0035728 response to hepatocyte growth factor 3/1165 19/18722 0.110788683491513 0.29796688089979 NRP1/GCLM/LGMN 3 GO:0036344 platelet morphogenesis 3/1165 19/18722 0.110788683491513 0.29796688089979 PRKDC/CIB1/PTPN6 3 GO:0043652 engulfment of apoptotic cell 3/1165 19/18722 0.110788683491513 0.29796688089979 RHOBTB1/TREM2/RHOG 3 GO:0046653 tetrahydrofolate metabolic process 3/1165 19/18722 0.110788683491513 0.29796688089979 ATIC/TYMS/GCH1 3 GO:0072074 kidney mesenchyme development 3/1165 19/18722 0.110788683491513 0.29796688089979 BMP7/STAT1/BASP1 3 GO:0086014 atrial cardiac muscle cell action potential 3/1165 19/18722 0.110788683491513 0.29796688089979 GJA5/GJA1/FLNA 3 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 3/1165 19/18722 0.110788683491513 0.29796688089979 GJA5/GJA1/FLNA 3 GO:0086066 atrial cardiac muscle cell to AV node cell communication 3/1165 19/18722 0.110788683491513 0.29796688089979 GJA5/GJA1/FLNA 3 GO:0090670 RNA localization to Cajal body 3/1165 19/18722 0.110788683491513 0.29796688089979 CCT2/RUVBL1/NHP2 3 GO:0090671 telomerase RNA localization to Cajal body 3/1165 19/18722 0.110788683491513 0.29796688089979 CCT2/RUVBL1/NHP2 3 GO:0090672 telomerase RNA localization 3/1165 19/18722 0.110788683491513 0.29796688089979 CCT2/RUVBL1/NHP2 3 GO:0090685 RNA localization to nucleus 3/1165 19/18722 0.110788683491513 0.29796688089979 CCT2/RUVBL1/NHP2 3 GO:1903978 regulation of microglial cell activation 3/1165 19/18722 0.110788683491513 0.29796688089979 PTPRC/TREM2/GRN 3 GO:2000251 positive regulation of actin cytoskeleton reorganization 3/1165 19/18722 0.110788683491513 0.29796688089979 NRP1/HCK/HRAS 3 GO:2000369 regulation of clathrin-dependent endocytosis 3/1165 19/18722 0.110788683491513 0.29796688089979 AAK1/DAB2/WASL 3 GO:2000738 positive regulation of stem cell differentiation 3/1165 19/18722 0.110788683491513 0.29796688089979 TACSTD2/PTN/DHX36 3 GO:0034637 cellular carbohydrate biosynthetic process 8/1165 78/18722 0.111254727816234 0.299077005379561 ISYNA1/SORBS1/AGL/FBP1/AKR1B1/PGP/IGF2/UGP2 8 GO:0014033 neural crest cell differentiation 9/1165 91/18722 0.11252510354468 0.302347250452986 SEMA6A/LAMA5/SEMA6D/BMP7/ISL1/NRP2/FOLR1/NRP1/PDCD6 9 GO:0051048 negative regulation of secretion 15/1165 171/18722 0.113007526424278 0.30246718199318 GJA1/FRMD4A/ERBB3/APOE/COMT/HLA-F/PNKD/SPI1/CD74/RSAD2/LILRB1/GNAI2/ERP29/CD300A/TNFRSF1B 15 GO:0006099 tricarboxylic acid cycle 4/1165 30/18722 0.113270268403646 0.30246718199318 IDH1/SUCLG1/MDH1/ACO2 4 GO:0006221 pyrimidine nucleotide biosynthetic process 4/1165 30/18722 0.113270268403646 0.30246718199318 UPP1/TYMS/NME1/DUT 4 GO:0007176 regulation of epidermal growth factor-activated receptor activity 4/1165 30/18722 0.113270268403646 0.30246718199318 APP/NCF1/VPS25/SNX6 4 GO:0007202 activation of phospholipase C activity 4/1165 30/18722 0.113270268403646 0.30246718199318 EGFR/CD86/PHB/S1PR4 4 GO:0015865 purine nucleotide transport 4/1165 30/18722 0.113270268403646 0.30246718199318 GJA1/SLC19A1/SLC25A5/SLC29A1 4 GO:0017145 stem cell division 4/1165 30/18722 0.113270268403646 0.30246718199318 ETV5/EVI2B/GNL3/NCOA3 4 GO:0019674 NAD metabolic process 4/1165 30/18722 0.113270268403646 0.30246718199318 LDHA/QPRT/MDH1/ENO1 4 GO:0031365 N-terminal protein amino acid modification 4/1165 30/18722 0.113270268403646 0.30246718199318 SOX4/NMT1/METAP2/NAA10 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/1165 30/18722 0.113270268403646 0.30246718199318 PRKDC/SOX4/CCND1/MDM2 4 GO:0046825 regulation of protein export from nucleus 4/1165 30/18722 0.113270268403646 0.30246718199318 PTPN14/MDM2/PARK7/YWHAE 4 GO:0051125 regulation of actin nucleation 4/1165 30/18722 0.113270268403646 0.30246718199318 SCIN/GMFG/WASF2/WASL 4 GO:0070229 negative regulation of lymphocyte apoptotic process 4/1165 30/18722 0.113270268403646 0.30246718199318 SLC39A10/EFNA1/CD74/TSC22D3 4 GO:0002040 sprouting angiogenesis 16/1165 185/18722 0.114234511488849 0.304896962903904 SEMA6A/EPHB4/TJP1/KLF2/NRP1/ITGB1/RHOA/VEGFA/PIK3C2A/KLF4/CIB1/RNF213/PKM/JAK1/GLUL/NR4A1 16 GO:0045600 positive regulation of fat cell differentiation 7/1165 66/18722 0.114983872086694 0.306459864208268 BMP7/LRP5/ADIRF/KLF5/ZFP36/CEBPB/ZFP36L1 7 GO:0050922 negative regulation of chemotaxis 7/1165 66/18722 0.114983872086694 0.306459864208268 SEMA6A/SEMA6D/DPP4/NRP1/AIF1/DUSP1/GSTP1 7 GO:0071300 cellular response to retinoic acid 7/1165 66/18722 0.114983872086694 0.306459864208268 SLC6A4/SERPINF1/YAP1/YES1/KLF4/HDAC2/LYN 7 GO:1990138 neuron projection extension 15/1165 172/18722 0.117101464401413 0.311955633452838 SEMA6A/SEMA6D/CXCR4/NRP2/PRKCZ/HSP90AB1/NRP1/APOE/HSP90AA1/ITGB1/GOLGA4/VEGFA/EIF2AK4/RAB11A/LRP1 15 GO:0001706 endoderm formation 6/1165 54/18722 0.117546731812895 0.312188717132724 COL4A2/LAMB1/DUSP5/ITGB5/DUSP1/RTF1 6 GO:0030834 regulation of actin filament depolymerization 6/1165 54/18722 0.117546731812895 0.312188717132724 SCIN/DSTN/LIMA1/EPS8/TRIOBP/ADD3 6 GO:0035065 regulation of histone acetylation 6/1165 54/18722 0.117546731812895 0.312188717132724 ISL1/GATA3/SPI1/BRD7/PARK7/SET 6 GO:0072348 sulfur compound transport 6/1165 54/18722 0.117546731812895 0.312188717132724 SLC26A2/SLC19A3/GJA1/SLC13A4/SLC13A3/SLC5A6 6 GO:0000413 protein peptidyl-prolyl isomerization 5/1165 42/18722 0.117800766593107 0.312188717132724 PPIC/PPIB/FKBP3/PPIA/FKBP2 5 GO:0016601 Rac protein signal transduction 5/1165 42/18722 0.117800766593107 0.312188717132724 HACD3/AIF1/EPS8/WASF2/RHOG 5 GO:0021879 forebrain neuron differentiation 5/1165 42/18722 0.117800766593107 0.312188717132724 B2M/NRP2/UQCRQ/NRP1/UBB 5 GO:0030808 regulation of nucleotide biosynthetic process 5/1165 42/18722 0.117800766593107 0.312188717132724 TMSB4X/PARP1/VCP/TREM2/ENO1 5 GO:0035019 somatic stem cell population maintenance 5/1165 42/18722 0.117800766593107 0.312188717132724 BMP7/LRP5/YAP1/SOX4/SPI1 5 GO:0045773 positive regulation of axon extension 5/1165 42/18722 0.117800766593107 0.312188717132724 NRP1/GOLGA4/VEGFA/RAB11A/LRP1 5 GO:0071312 cellular response to alkaloid 5/1165 42/18722 0.117800766593107 0.312188717132724 AIF1/TGM2/SLC1A3/MDM2/SLC8A1 5 GO:2001022 positive regulation of response to DNA damage stimulus 10/1165 105/18722 0.117974075948768 0.312500466399451 EGFR/PARP1/PMAIP1/PRKDC/SKIL/FUS/BCLAF1/BABAM1/RPS3/PARP9 10 GO:0072503 cellular divalent inorganic cation homeostasis 37/1165 486/18722 0.118656095977363 0.314158805057045 GJA1/CXCR4/APP/SLC39A10/CYBA/HSP90B1/CD24/APOE/ATP2B1/S100A8/TGM2/PTPRC/CD55/AFG3L2/ATP2B4/SLC11A1/PTPN6/SLC39A7/CD52/STOML2/GSTO1/FPR1/CCDC47/FPR3/CALR/ERO1A/CXCL10/TMEM165/YWHAE/S1PR4/FIS1/CLN3/BNIP3/SLC8A1/LRP1/JAK2/LYN 37 GO:0090596 sensory organ morphogenesis 21/1165 256/18722 0.119193017176432 0.315431591424474 FBN1/TENM3/FBN2/EFEMP1/BMP7/LRP5/GATA3/ATP6V1B1/TFAP2A/GLI3/SOD1/OBSL1/MYO7A/MFAP5/PTN/DLX5/VEGFA/TRIOBP/HDAC2/C12orf57/HMGN1 21 GO:0032200 telomere organization 14/1165 159/18722 0.119900357872706 0.317004573122704 PKIB/PARP1/HSP90AB1/HSP90AA1/PRKDC/CCNE1/CCT2/DHX36/GNL3/RAD50/RPA3/RFC1/NHP2/APEX1 14 GO:0051170 import into nucleus 14/1165 159/18722 0.119900357872706 0.317004573122704 CDH1/FERMT1/GLI3/HSP90AB1/RPL23/NFKBIA/FLNA/RAN/TGFB1/TXNIP/TNPO1/SYK/JAK2/NUP214 14 GO:1903317 regulation of protein maturation 7/1165 67/18722 0.121929961245151 0.318917278673969 BAG2/PRKACB/SOX4/MDM2/ENO1/CLN3/ADAM8 7 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 7/1165 67/18722 0.121929961245151 0.318917278673969 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD55/CD86/CD83 7 GO:0043543 protein acylation 20/1165 243/18722 0.122964194758977 0.318917278673969 ISL1/GATA3/MORF4L2/SOX4/HINT2/SPI1/USP22/RUVBL1/BRD7/DLD/NMT1/NCOA3/PARK7/CDYL/HDAC2/MORF4L1/NAA10/SET/GLUL/PHF20 20 GO:0030212 hyaluronan metabolic process 4/1165 31/18722 0.124008563531734 0.318917278673969 ITIH5/CD44/CLTC/TGFB1 4 GO:0034656 nucleobase-containing small molecule catabolic process 4/1165 31/18722 0.124008563531734 0.318917278673969 APOBEC3A/UPP1/MGAT1/PNP 4 GO:0036474 cell death in response to hydrogen peroxide 4/1165 31/18722 0.124008563531734 0.318917278673969 MET/PAWR/STK26/PARK7 4 GO:0036475 neuron death in response to oxidative stress 4/1165 31/18722 0.124008563531734 0.318917278673969 PARP1/ARL6IP5/TREM2/PARK7 4 GO:0044819 mitotic G1/S transition checkpoint signaling 4/1165 31/18722 0.124008563531734 0.318917278673969 PRKDC/SOX4/CCND1/MDM2 4 GO:0060055 angiogenesis involved in wound healing 4/1165 31/18722 0.124008563531734 0.318917278673969 DAG1/CXCR4/GPX1/VEGFA 4 GO:0061099 negative regulation of protein tyrosine kinase activity 4/1165 31/18722 0.124008563531734 0.318917278673969 PTPRC/VPS25/LILRB4/SNX6 4 GO:1905144 response to acetylcholine 4/1165 31/18722 0.124008563531734 0.318917278673969 GNA11/ATP2B4/RGS10/GNAI2 4 GO:1905145 cellular response to acetylcholine 4/1165 31/18722 0.124008563531734 0.318917278673969 GNA11/ATP2B4/RGS10/GNAI2 4 GO:2000144 positive regulation of DNA-templated transcription, initiation 4/1165 31/18722 0.124008563531734 0.318917278673969 DHX36/PSMC6/BCLAF1/JUN 4 GO:1902807 negative regulation of cell cycle G1/S phase transition 9/1165 93/18722 0.124157433994297 0.318917278673969 CTDSPL/WEE1/DLG1/PRKDC/SOX4/CCND1/KLF4/BRD7/MDM2 9 GO:0002834 regulation of response to tumor cell 3/1165 20/18722 0.124608712225994 0.318917278673969 HSPD1/HLA-DRB1/IL4I1 3 GO:0002837 regulation of immune response to tumor cell 3/1165 20/18722 0.124608712225994 0.318917278673969 HSPD1/HLA-DRB1/IL4I1 3 GO:0003159 morphogenesis of an endothelium 3/1165 20/18722 0.124608712225994 0.318917278673969 CXCR4/RHOA/CXCL10 3 GO:0003215 cardiac right ventricle morphogenesis 3/1165 20/18722 0.124608712225994 0.318917278673969 ISL1/GATA3/SOX4 3 GO:0006837 serotonin transport 3/1165 20/18722 0.124608712225994 0.318917278673969 SLC6A4/LILRB1/SYK 3 GO:0006883 cellular sodium ion homeostasis 3/1165 20/18722 0.124608712225994 0.318917278673969 SLC9A1/SLC1A3/SLC8A1 3 GO:0009713 catechol-containing compound biosynthetic process 3/1165 20/18722 0.124608712225994 0.318917278673969 GATA3/PARK7/GCH1 3 GO:0042423 catecholamine biosynthetic process 3/1165 20/18722 0.124608712225994 0.318917278673969 GATA3/PARK7/GCH1 3 GO:0043555 regulation of translation in response to stress 3/1165 20/18722 0.124608712225994 0.318917278673969 NPM1/EIF2AK1/EIF2AK4 3 GO:0043586 tongue development 3/1165 20/18722 0.124608712225994 0.318917278673969 EGFR/GLI3/HDAC2 3 GO:0060231 mesenchymal to epithelial transition 3/1165 20/18722 0.124608712225994 0.318917278673969 GATA3/STAT1/BASP1 3 GO:0061154 endothelial tube morphogenesis 3/1165 20/18722 0.124608712225994 0.318917278673969 CXCR4/RHOA/CXCL10 3 GO:0071243 cellular response to arsenic-containing substance 3/1165 20/18722 0.124608712225994 0.318917278673969 VCP/DHX36/GSTO1 3 GO:1901679 nucleotide transmembrane transport 3/1165 20/18722 0.124608712225994 0.318917278673969 SLC19A1/SLC25A5/SLC25A36 3 GO:2000678 negative regulation of transcription regulatory region DNA binding 3/1165 20/18722 0.124608712225994 0.318917278673969 TMSB4X/MSX2/ZNF593 3 GO:0000255 allantoin metabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 DNPH1/PNP 2 GO:0000492 box C/D snoRNP assembly 2/1165 10/18722 0.124941937609844 0.318917278673969 SNU13/RUVBL1 2 GO:0001915 negative regulation of T cell mediated cytotoxicity 2/1165 10/18722 0.124941937609844 0.318917278673969 PTPRC/LILRB1 2 GO:0002002 regulation of angiotensin levels in blood 2/1165 10/18722 0.124941937609844 0.318917278673969 ENPEP/MME 2 GO:0002003 angiotensin maturation 2/1165 10/18722 0.124941937609844 0.318917278673969 ENPEP/MME 2 GO:0002524 hypersensitivity 2/1165 10/18722 0.124941937609844 0.318917278673969 GATA3/HLA-E 2 GO:0002887 negative regulation of myeloid leukocyte mediated immunity 2/1165 10/18722 0.124941937609844 0.318917278673969 SPI1/CD300A 2 GO:0003056 regulation of vascular associated smooth muscle contraction 2/1165 10/18722 0.124941937609844 0.318917278673969 ATP2B1/RHOA 2 GO:0003163 sinoatrial node development 2/1165 10/18722 0.124941937609844 0.318917278673969 ISL1/TBX3 2 GO:0003183 mitral valve morphogenesis 2/1165 10/18722 0.124941937609844 0.318917278673969 EFNA1/SOX4 2 GO:0006283 transcription-coupled nucleotide-excision repair 2/1165 10/18722 0.124941937609844 0.318917278673969 POLR2I/HMGN1 2 GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 DNPH1/PNP 2 GO:0009396 folic acid-containing compound biosynthetic process 2/1165 10/18722 0.124941937609844 0.318917278673969 ATIC/GCH1 2 GO:0016139 glycoside catabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 FUCA1/FUCA2 2 GO:0021562 vestibulocochlear nerve development 2/1165 10/18722 0.124941937609844 0.318917278673969 NRP2/NRP1 2 GO:0021932 hindbrain radial glia guided cell migration 2/1165 10/18722 0.124941937609844 0.318917278673969 ITGB1/FLNA 2 GO:0030214 hyaluronan catabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 CD44/TGFB1 2 GO:0030388 fructose 1,6-bisphosphate metabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 ALDOA/FBP1 2 GO:0030953 astral microtubule organization 2/1165 10/18722 0.124941937609844 0.318917278673969 DLG1/RAB11A 2 GO:0031055 chromatin remodeling at centromere 2/1165 10/18722 0.124941937609844 0.318917278673969 NASP/HELLS 2 GO:0032025 response to cobalt ion 2/1165 10/18722 0.124941937609844 0.318917278673969 SERPINF1/BNIP3 2 GO:0032070 regulation of deoxyribonuclease activity 2/1165 10/18722 0.124941937609844 0.318917278673969 NPM1/RPS3 2 GO:0032275 luteinizing hormone secretion 2/1165 10/18722 0.124941937609844 0.318917278673969 TBX3/CGA 2 GO:0033572 transferrin transport 2/1165 10/18722 0.124941937609844 0.318917278673969 TFRC/CLTC 2 GO:0034756 regulation of iron ion transport 2/1165 10/18722 0.124941937609844 0.318917278673969 B2M/ISCU 2 GO:0043101 purine-containing compound salvage 2/1165 10/18722 0.124941937609844 0.318917278673969 ADK/PNP 2 GO:0044557 relaxation of smooth muscle 2/1165 10/18722 0.124941937609844 0.318917278673969 SOD1/SLC8A1 2 GO:0051351 positive regulation of ligase activity 2/1165 10/18722 0.124941937609844 0.318917278673969 TMSB4X/GCLM 2 GO:0061299 retina vasculature morphogenesis in camera-type eye 2/1165 10/18722 0.124941937609844 0.318917278673969 LRP5/NRP1 2 GO:0071421 manganese ion transmembrane transport 2/1165 10/18722 0.124941937609844 0.318917278673969 SLC11A1/TMEM165 2 GO:0072178 nephric duct morphogenesis 2/1165 10/18722 0.124941937609844 0.318917278673969 GATA3/GPC3 2 GO:0090209 negative regulation of triglyceride metabolic process 2/1165 10/18722 0.124941937609844 0.318917278673969 APOE/SORL1 2 GO:0090647 modulation of age-related behavioral decline 2/1165 10/18722 0.124941937609844 0.318917278673969 B2M/APP 2 GO:0098885 modification of postsynaptic actin cytoskeleton 2/1165 10/18722 0.124941937609844 0.318917278673969 MYH10/RHOA 2 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 2/1165 10/18722 0.124941937609844 0.318917278673969 NSG1/RAB11A 2 GO:0140059 dendrite arborization 2/1165 10/18722 0.124941937609844 0.318917278673969 NRP1/PTN 2 GO:1901203 positive regulation of extracellular matrix assembly 2/1165 10/18722 0.124941937609844 0.318917278673969 DAG1/TGFB1 2 GO:1901524 regulation of mitophagy 2/1165 10/18722 0.124941937609844 0.318917278673969 SLC25A5/VDAC1 2 GO:1902023 L-arginine transport 2/1165 10/18722 0.124941937609844 0.318917278673969 SLC38A9/SLC11A1 2 GO:1903867 extraembryonic membrane development 2/1165 10/18722 0.124941937609844 0.318917278673969 BMP7/HTRA1 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/1165 10/18722 0.124941937609844 0.318917278673969 LRP2/LRP1 2 GO:1905809 negative regulation of synapse organization 2/1165 10/18722 0.124941937609844 0.318917278673969 PTN/TLR2 2 GO:1990253 cellular response to leucine starvation 2/1165 10/18722 0.124941937609844 0.318917278673969 SESN1/EIF2AK4 2 GO:2000121 regulation of removal of superoxide radicals 2/1165 10/18722 0.124941937609844 0.318917278673969 BMP7/GCH1 2 GO:2000425 regulation of apoptotic cell clearance 2/1165 10/18722 0.124941937609844 0.318917278673969 TGM2/TREM2 2 GO:2000434 regulation of protein neddylation 2/1165 10/18722 0.124941937609844 0.318917278673969 EPAS1/RPL5 2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 2/1165 10/18722 0.124941937609844 0.318917278673969 WASF2/WASL 2 GO:0046887 positive regulation of hormone secretion 12/1165 133/18722 0.125075169668692 0.319112239704712 EGFR/GJA1/ISL1/MPC2/HLA-DRB1/SOX4/SERP1/RETN/BAD/GLUL/LRP1/JAK2 12 GO:0003179 heart valve morphogenesis 6/1165 55/18722 0.125425224552078 0.319569580304499 GJA5/GATA3/EFNA1/SOX4/TGFB1/MDM2 6 GO:0045620 negative regulation of lymphocyte differentiation 6/1165 55/18722 0.125425224552078 0.319569580304499 GLI3/PRDX2/FGL2/IRF1/CD74/LILRB4 6 GO:0051898 negative regulation of protein kinase B signaling 6/1165 55/18722 0.125425224552078 0.319569580304499 DAG1/PHLDA3/DLG1/KLF4/CIB1/PDCD6 6 GO:0055074 calcium ion homeostasis 35/1165 460/18722 0.126816760241076 0.322269257311934 GJA1/CXCR4/APP/ATP6V1B1/CYBA/HSP90B1/CD24/SNX10/APOE/ATP2B1/TGM2/PTPRC/CD55/AFG3L2/ATP2B4/PTPN6/CD52/STOML2/GSTO1/FPR1/CCDC47/FPR3/CALR/ERO1A/CXCL10/TMEM165/YWHAE/S1PR4/FIS1/CLN3/BNIP3/SLC8A1/LRP1/JAK2/LYN 35 GO:0010171 body morphogenesis 5/1165 43/18722 0.126886702059393 0.322269257311934 DAG1/ARID5B/GPC3/DLX5/RRAS 5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5/1165 43/18722 0.126886702059393 0.322269257311934 CD44/PHLDA3/CD74/PYCARD/IFI16 5 GO:0045981 positive regulation of nucleotide metabolic process 5/1165 43/18722 0.126886702059393 0.322269257311934 APP/TMSB4X/VCP/TREM2/ENO1 5 GO:0061383 trabecula morphogenesis 5/1165 43/18722 0.126886702059393 0.322269257311934 FBN2/TGFBR3/ADAMTS1/BMP7/RHOA 5 GO:0098927 vesicle-mediated transport between endosomal compartments 5/1165 43/18722 0.126886702059393 0.322269257311934 DAB2/FLNA/MSN/SNX3/SORL1 5 GO:1900544 positive regulation of purine nucleotide metabolic process 5/1165 43/18722 0.126886702059393 0.322269257311934 APP/TMSB4X/VCP/TREM2/ENO1 5 GO:0007052 mitotic spindle organization 11/1165 120/18722 0.127283451755866 0.322842178691486 TACC2/GNAI1/VCP/RHOA/FLNA/CLTC/RAN/STMN1/RAB11A/SMC3/CCNB1 11 GO:0072655 establishment of protein localization to mitochondrion 11/1165 120/18722 0.127283451755866 0.322842178691486 HSPD1/LMAN1/BNIP3L/HSP90AA1/PMPCB/TIMM13/NMT1/ROMO1/FIS1/TSPO/TIMM8B 11 GO:1902850 microtubule cytoskeleton organization involved in mitosis 13/1165 147/18722 0.127284828334983 0.322842178691486 TACC2/GJA1/GNAI1/ITGB1/VCP/RHOA/FLNA/CLTC/RAN/STMN1/RAB11A/SMC3/CCNB1 13 GO:0010927 cellular component assembly involved in morphogenesis 10/1165 107/18722 0.129064171485149 0.326524541925015 ITGB4/DAG1/KRT8/GPC1/OBSL1/CSRP2/ITGB1/CD9/KRT19/TLR2 10 GO:0021761 limbic system development 10/1165 107/18722 0.129064171485149 0.326524541925015 NRP2/CDK6/GLI3/UQCRQ/TBX3/ANXA3/NRP1/UBB/ATP2B4/NME1 10 GO:0071868 cellular response to monoamine stimulus 10/1165 107/18722 0.129064171485149 0.326524541925015 NSG1/APP/SLC9A1/GNAS/ID1/GNA11/TGM2/FLNA/ATP2B4/HDAC2 10 GO:0071870 cellular response to catecholamine stimulus 10/1165 107/18722 0.129064171485149 0.326524541925015 NSG1/APP/SLC9A1/GNAS/ID1/GNA11/TGM2/FLNA/ATP2B4/HDAC2 10 GO:0010812 negative regulation of cell-substrate adhesion 7/1165 68/18722 0.129085686536898 0.326524541925015 KANK1/FBLN1/TACSTD2/RASA1/GBP1/RHOA/LRP1 7 GO:1901016 regulation of potassium ion transmembrane transporter activity 7/1165 68/18722 0.129085686536898 0.326524541925015 ANK3/KCNG1/ITGB1/DLG1/AKAP9/TREM2/YWHAE 7 GO:0050954 sensory perception of mechanical stimulus 15/1165 175/18722 0.129900489020181 0.328437587779402 LRP2/USP53/CXCR4/ALDH7A1/ATP6V1B1/TFAP2A/SOD1/MYO7A/TBL1X/GPX1/TIMM13/SLC1A3/TRIOBP/NDUFB9/TIMM8B 15 GO:0002042 cell migration involved in sprouting angiogenesis 9/1165 94/18722 0.130206431188595 0.329062898812059 EPHB4/NRP1/ITGB1/RHOA/VEGFA/PIK3C2A/KLF4/CIB1/NR4A1 9 GO:0000422 autophagy of mitochondrion 8/1165 81/18722 0.130386497748155 0.329221507809445 BNIP3L/SLC25A5/PARK7/FIS1/TSPO/BNIP3/VDAC1/GABARAPL1 8 GO:0061726 mitochondrion disassembly 8/1165 81/18722 0.130386497748155 0.329221507809445 BNIP3L/SLC25A5/PARK7/FIS1/TSPO/BNIP3/VDAC1/GABARAPL1 8 GO:0044272 sulfur compound biosynthetic process 13/1165 148/18722 0.13208872165315 0.333369601906085 ACSS1/SLC26A2/CHPF/MPC2/GCLM/CDO1/ADI1/GSTP1/MTR/TECR/DLD/ST3GAL4/SLC25A1 13 GO:0046622 positive regulation of organ growth 6/1165 56/18722 0.133553489188354 0.336310334147255 TGFBR3/YAP1/SERP1/BASP1/IGF2/CCNB1 6 GO:0048255 mRNA stabilization 6/1165 56/18722 0.133553489188354 0.336310334147255 ZFP36/FUS/SLC11A1/PABPC1/YBX1/CIRBP 6 GO:0051784 negative regulation of nuclear division 6/1165 56/18722 0.133553489188354 0.336310334147255 BMP7/DUSP1/AURKAIP1/CENPF/RAD21/CCNB1 6 GO:0055078 sodium ion homeostasis 6/1165 56/18722 0.133553489188354 0.336310334147255 ATP6V1B1/SLC9A1/COMT/SLC1A3/GNAI2/SLC8A1 6 GO:1990089 response to nerve growth factor 6/1165 56/18722 0.133553489188354 0.336310334147255 APP/PTN/ID1/HSPA5/ARPC3/CIB1 6 GO:0003338 metanephros morphogenesis 4/1165 32/18722 0.135158910378299 0.338832945043945 LGR4/FRAS1/STAT1/BASP1 4 GO:0010644 cell communication by electrical coupling 4/1165 32/18722 0.135158910378299 0.338832945043945 GJA5/GJA1/ANK3/SLC8A1 4 GO:0033687 osteoblast proliferation 4/1165 32/18722 0.135158910378299 0.338832945043945 LRP5/RHOA/JUNB/ATRAID 4 GO:0045879 negative regulation of smoothened signaling pathway 4/1165 32/18722 0.135158910378299 0.338832945043945 GLI3/GPC3/VCP/PRKACB 4 GO:0048841 regulation of axon extension involved in axon guidance 4/1165 32/18722 0.135158910378299 0.338832945043945 SEMA6A/SEMA6D/NRP1/VEGFA 4 GO:0051642 centrosome localization 4/1165 32/18722 0.135158910378299 0.338832945043945 SYNE2/ASPM/DLG1/AKAP9 4 GO:0060317 cardiac epithelial to mesenchymal transition 4/1165 32/18722 0.135158910378299 0.338832945043945 TGFBR3/TBX3/EFNA1/PDCD4 4 GO:0090022 regulation of neutrophil chemotaxis 4/1165 32/18722 0.135158910378299 0.338832945043945 DPP4/JAM3/C1QBP/CD74 4 GO:0097345 mitochondrial outer membrane permeabilization 4/1165 32/18722 0.135158910378299 0.338832945043945 BNIP3L/SLC25A5/NMT1/BNIP3 4 GO:1901185 negative regulation of ERBB signaling pathway 4/1165 32/18722 0.135158910378299 0.338832945043945 EGFR/LGMN/VPS25/SNX6 4 GO:0007528 neuromuscular junction development 5/1165 44/18722 0.1362824030422 0.340736360033794 APP/ANK3/PPFIBP1/PTN/AFG3L2 5 GO:0032881 regulation of polysaccharide metabolic process 5/1165 44/18722 0.1362824030422 0.340736360033794 PHLDA2/SORBS1/CLTC/TGFB1/IGF2 5 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 5/1165 44/18722 0.1362824030422 0.340736360033794 DLG5/DLG1/RHOA/MSN/ARF4 5 GO:0046006 regulation of activated T cell proliferation 5/1165 44/18722 0.1362824030422 0.340736360033794 CD24/PYCARD/LILRB4/IGF2/RPS3 5 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 5/1165 44/18722 0.1362824030422 0.340736360033794 PRLR/AKR1B1/IL10RB/CD300A/JAK2 5 GO:0150076 neuroinflammatory response 5/1165 44/18722 0.1362824030422 0.340736360033794 ITGB1/PTPRC/TREM2/TNFRSF1B/GRN 5 GO:1901379 regulation of potassium ion transmembrane transport 9/1165 95/18722 0.13640782308177 0.340843495153113 ANK3/KCNN4/KCNG1/ITGB1/DLG1/FLNA/AKAP9/TREM2/YWHAE 9 GO:0007004 telomere maintenance via telomerase 7/1165 69/18722 0.136446701159637 0.340843495153113 PKIB/HSP90AB1/HSP90AA1/CCT2/RAD50/RFC1/NHP2 7 GO:0016525 negative regulation of angiogenesis 13/1165 149/18722 0.136992250443232 0.342054048815775 SEMA6A/COL4A2/ADAMTS1/SERPINF1/AMOT/KLF2/PTN/STAT1/FOXO4/KLF4/ATP2B4/PGK1/CXCL10 13 GO:0072527 pyrimidine-containing compound metabolic process 8/1165 82/18722 0.137117210654927 0.342061734847157 TYMP/SLC19A3/APOBEC3A/UPP1/AK3/TYMS/NME1/DUT 8 GO:2001252 positive regulation of chromosome organization 8/1165 82/18722 0.137117210654927 0.342061734847157 PKIB/DNMT1/CCT2/DHX36/GNL3/RAD50/SSBP1/RAD21 8 GO:2001020 regulation of response to DNA damage stimulus 18/1165 219/18722 0.13887447498906 0.343426217728083 EGFR/CD44/PARP1/NPM1/MAGEF1/PMAIP1/PRKDC/IER3/SKIL/CD74/FUS/SMYD2/MDM2/USP47/BCLAF1/BABAM1/RPS3/PARP9 18 GO:0000002 mitochondrial genome maintenance 3/1165 21/18722 0.139010220323927 0.343426217728083 TYMP/PARP1/SLC25A36 3 GO:0003091 renal water homeostasis 3/1165 21/18722 0.139010220323927 0.343426217728083 ATP6V1B1/AKR1B1/PRKACB 3 GO:0006067 ethanol metabolic process 3/1165 21/18722 0.139010220323927 0.343426217728083 ACSS1/ADH5/ALDH2 3 GO:0006244 pyrimidine nucleotide catabolic process 3/1165 21/18722 0.139010220323927 0.343426217728083 TYMP/UPP1/DUT 3 GO:0010988 regulation of low-density lipoprotein particle clearance 3/1165 21/18722 0.139010220323927 0.343426217728083 MYLIP/TREM2/CNPY2 3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 3/1165 21/18722 0.139010220323927 0.343426217728083 GMFG/WASF2/WASL 3 GO:0038083 peptidyl-tyrosine autophosphorylation 3/1165 21/18722 0.139010220323927 0.343426217728083 EGFR/IGF1R/VEGFA 3 GO:0042454 ribonucleoside catabolic process 3/1165 21/18722 0.139010220323927 0.343426217728083 APOBEC3A/UPP1/PNP 3 GO:0044766 multi-organism transport 3/1165 21/18722 0.139010220323927 0.343426217728083 CTSL/IFIT1/BST2 3 GO:0048199 vesicle targeting, to, from or within Golgi 3/1165 21/18722 0.139010220323927 0.343426217728083 TFG/TMED9/PDCD6 3 GO:0060117 auditory receptor cell development 3/1165 21/18722 0.139010220323927 0.343426217728083 SOD1/MYO7A/TRIOBP 3 GO:0070584 mitochondrion morphogenesis 3/1165 21/18722 0.139010220323927 0.343426217728083 SLIRP/SSBP1/FIS1 3 GO:0071605 monocyte chemotactic protein-1 production 3/1165 21/18722 0.139010220323927 0.343426217728083 GSTP1/OAS1/SYK 3 GO:0071637 regulation of monocyte chemotactic protein-1 production 3/1165 21/18722 0.139010220323927 0.343426217728083 GSTP1/OAS1/SYK 3 GO:0072170 metanephric tubule development 3/1165 21/18722 0.139010220323927 0.343426217728083 LGR4/YAP1/STAT1 3 GO:0072243 metanephric nephron epithelium development 3/1165 21/18722 0.139010220323927 0.343426217728083 LGR4/YAP1/STAT1 3 GO:0090026 positive regulation of monocyte chemotaxis 3/1165 21/18722 0.139010220323927 0.343426217728083 AIF1/LGMN/CXCL10 3 GO:0097062 dendritic spine maintenance 3/1165 21/18722 0.139010220323927 0.343426217728083 IGF1R/APOE/TREM2 3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/1165 21/18722 0.139010220323927 0.343426217728083 CD44/CD74/MDM2 3 GO:1902307 positive regulation of sodium ion transmembrane transport 3/1165 21/18722 0.139010220323927 0.343426217728083 ANK3/SLC9A1/GLRX 3 GO:1902579 multi-organism localization 3/1165 21/18722 0.139010220323927 0.343426217728083 CTSL/IFIT1/BST2 3 GO:0062012 regulation of small molecule metabolic process 26/1165 334/18722 0.141226754434345 0.348192907768146 PHLDA2/SORBS1/APP/TMSB4X/PARP1/SOD1/SLC35B4/DDB1/APOE/COMT/FBP1/PMAIP1/VCP/PGP/APOC1/ATP2B4/CD74/TREM2/PARK7/ENO1/IGF2/BAD/FAM3C/CLN3/ACADVL/SLC7A7 26 GO:0006695 cholesterol biosynthetic process 6/1165 57/18722 0.141924466327547 0.348192907768146 SOD1/DHCR24/FDFT1/APOE/FDPS/PMVK 6 GO:0030219 megakaryocyte differentiation 6/1165 57/18722 0.141924466327547 0.348192907768146 SCIN/PITHD1/CIB1/WASF2/PTPN6/PRMT1 6 GO:0051289 protein homotetramerization 6/1165 57/18722 0.141924466327547 0.348192907768146 B2M/SOD2/ALDOA/GBP5/VASP/SSBP1 6 GO:1902653 secondary alcohol biosynthetic process 6/1165 57/18722 0.141924466327547 0.348192907768146 SOD1/DHCR24/FDFT1/APOE/FDPS/PMVK 6 GO:0003073 regulation of systemic arterial blood pressure 9/1165 96/18722 0.142759207203904 0.348192907768146 NR2F2/GJA5/ENPEP/MME/ADRB1/GJA1/SOD2/CYBA/RHOA 9 GO:0034620 cellular response to unfolded protein 9/1165 96/18722 0.142759207203904 0.348192907768146 HSPD1/HSPA5/VCP/CCND1/SERP1/ERO1A/UFL1/CREB3L2/HSPA8 9 GO:0050806 positive regulation of synaptic transmission 14/1165 164/18722 0.142964088455544 0.348192907768146 EGFR/MME/NSG1/TYROBP/APP/PRKCZ/APOE/PTN/LGMN/EIF2AK4/SLC1A3/LILRB2/RETN/GLUL 14 GO:0003231 cardiac ventricle development 11/1165 123/18722 0.143709973772377 0.348192907768146 LRP2/TGFBR3/GJA5/DSP/ISL1/LMO4/GATA3/TBX3/SOX4/TGFB1/MDM2 11 GO:0043367 CD4-positive, alpha-beta T cell differentiation 8/1165 83/18722 0.144019349716032 0.348192907768146 CTSL/GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86/RSAD2/CD83 8 GO:0045926 negative regulation of growth 20/1165 249/18722 0.1454854648553 0.348192907768146 SEMA6A/SEMA6D/SLC6A4/ADRB1/GJA1/GPC3/RBBP7/NRP1/EI24/FBP1/LGMN/SMARCA2/PLAC8/TGFB1/GDF15/ENO1/PHB/BST2/CGA/NDUFS3 20 GO:0008203 cholesterol metabolic process 12/1165 137/18722 0.1457686692369 0.348192907768146 LRP5/APP/SOD1/DHCR24/LIMA1/FDFT1/APOE/FDPS/PMVK/FDX1/ACADVL/APOBR 12 GO:0060048 cardiac muscle contraction 12/1165 137/18722 0.1457686692369 0.348192907768146 GJA5/DSP/DSG2/GJA1/CXCR4/DSC2/SLC9A1/DLG1/FLNA/AKAP9/GSTO1/SLC8A1 12 GO:0090090 negative regulation of canonical Wnt signaling pathway 12/1165 137/18722 0.1457686692369 0.348192907768146 FERMT1/ISL1/ZNRF3/GLI3/NOTUM/GPC3/APOE/DAB2/SIAH2/LATS2/PFDN5/TLE4 12 GO:0030835 negative regulation of actin filament depolymerization 5/1165 45/18722 0.145975800557913 0.348192907768146 SCIN/LIMA1/EPS8/TRIOBP/ADD3 5 GO:0035384 thioester biosynthetic process 5/1165 45/18722 0.145975800557913 0.348192907768146 ACSS1/MPC2/TECR/DLD/SLC25A1 5 GO:0046189 phenol-containing compound biosynthetic process 5/1165 45/18722 0.145975800557913 0.348192907768146 GATA3/OPN3/PARK7/GCH1/ZEB2 5 GO:0071616 acyl-CoA biosynthetic process 5/1165 45/18722 0.145975800557913 0.348192907768146 ACSS1/MPC2/TECR/DLD/SLC25A1 5 GO:0042742 defense response to bacterium 27/1165 350/18722 0.146222559459708 0.348192907768146 LYZ/HLA-A/COLEC12/ISG15/CYBA/HLA-E/FCER1G/ANXA3/GBP2/CEBPB/S100A8/GBP4/TREM1/PLAC8/PYCARD/SLC11A1/TREM2/OAS1/OAS2/S100A12/FGR/TLR2/ROMO1/DEFB1/CFP/SYK/GRN 27 GO:0001731 formation of translation preinitiation complex 2/1165 11/18722 0.146661069530246 0.348192907768146 EIF2S2/EIF5 2 GO:0001867 complement activation, lectin pathway 2/1165 11/18722 0.146661069530246 0.348192907768146 FCN1/A2M 2 GO:0002645 positive regulation of tolerance induction 2/1165 11/18722 0.146661069530246 0.348192907768146 LILRB2/LILRB4 2 GO:0002725 negative regulation of T cell cytokine production 2/1165 11/18722 0.146661069530246 0.348192907768146 HLA-F/LILRB4 2 GO:0002732 positive regulation of dendritic cell cytokine production 2/1165 11/18722 0.146661069530246 0.348192907768146 DHX36/DDX1 2 GO:0003139 secondary heart field specification 2/1165 11/18722 0.146661069530246 0.348192907768146 LRP2/ISL1 2 GO:0006002 fructose 6-phosphate metabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 FBP1/GFPT1 2 GO:0006020 inositol metabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 ISYNA1/SLC5A3 2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 2/1165 11/18722 0.146661069530246 0.348192907768146 MPC2/DLD 2 GO:0006183 GTP biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 NME1/IMPDH2 2 GO:0006188 IMP biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 PAICS/ATIC 2 GO:0006568 tryptophan metabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 IL4I1/KYNU 2 GO:0007042 lysosomal lumen acidification 2/1165 11/18722 0.146661069530246 0.348192907768146 CLN3/GRN 2 GO:0009128 purine nucleoside monophosphate catabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 DNPH1/PNP 2 GO:0009155 purine deoxyribonucleotide catabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 DNPH1/PNP 2 GO:0009235 cobalamin metabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 MTR/MMADHC 2 GO:0010269 response to selenium ion 2/1165 11/18722 0.146661069530246 0.348192907768146 SOD2/GPX1 2 GO:0021561 facial nerve development 2/1165 11/18722 0.146661069530246 0.348192907768146 NRP2/NRP1 2 GO:0021604 cranial nerve structural organization 2/1165 11/18722 0.146661069530246 0.348192907768146 NRP2/NRP1 2 GO:0021610 facial nerve morphogenesis 2/1165 11/18722 0.146661069530246 0.348192907768146 NRP2/NRP1 2 GO:0021889 olfactory bulb interneuron differentiation 2/1165 11/18722 0.146661069530246 0.348192907768146 DLX5/ATF5 2 GO:0030432 peristalsis 2/1165 11/18722 0.146661069530246 0.348192907768146 TBX3/DLG1 2 GO:0031442 positive regulation of mRNA 3'-end processing 2/1165 11/18722 0.146661069530246 0.348192907768146 DHX36/CCNB1 2 GO:0032493 response to bacterial lipoprotein 2/1165 11/18722 0.146661069530246 0.348192907768146 CD14/TLR2 2 GO:0032610 interleukin-1 alpha production 2/1165 11/18722 0.146661069530246 0.348192907768146 ISL1/S100A13 2 GO:0032650 regulation of interleukin-1 alpha production 2/1165 11/18722 0.146661069530246 0.348192907768146 ISL1/S100A13 2 GO:0033197 response to vitamin E 2/1165 11/18722 0.146661069530246 0.348192907768146 CCND1/SRSF2 2 GO:0033327 Leydig cell differentiation 2/1165 11/18722 0.146661069530246 0.348192907768146 CCND1/SF1 2 GO:0033483 gas homeostasis 2/1165 11/18722 0.146661069530246 0.348192907768146 SOD2/GSTP1 2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2/1165 11/18722 0.146661069530246 0.348192907768146 ETFA/ACADVL 2 GO:0033625 positive regulation of integrin activation 2/1165 11/18722 0.146661069530246 0.348192907768146 FERMT1/FERMT2 2 GO:0039530 MDA-5 signaling pathway 2/1165 11/18722 0.146661069530246 0.348192907768146 C1QBP/IRF7 2 GO:0042416 dopamine biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 PARK7/GCH1 2 GO:0042451 purine nucleoside biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 ADK/PNP 2 GO:0042455 ribonucleoside biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 ADK/PNP 2 GO:0043589 skin morphogenesis 2/1165 11/18722 0.146661069530246 0.348192907768146 ITGB4/ITGA6 2 GO:0045628 regulation of T-helper 2 cell differentiation 2/1165 11/18722 0.146661069530246 0.348192907768146 PRKCZ/CD86 2 GO:0045654 positive regulation of megakaryocyte differentiation 2/1165 11/18722 0.146661069530246 0.348192907768146 SCIN/PITHD1 2 GO:0045793 positive regulation of cell size 2/1165 11/18722 0.146661069530246 0.348192907768146 HSP90AB1/TMEM123 2 GO:0046129 purine ribonucleoside biosynthetic process 2/1165 11/18722 0.146661069530246 0.348192907768146 ADK/PNP 2 GO:0046501 protoporphyrinogen IX metabolic process 2/1165 11/18722 0.146661069530246 0.348192907768146 EIF2AK1/UROD 2 GO:0051657 maintenance of organelle location 2/1165 11/18722 0.146661069530246 0.348192907768146 ASPM/AKAP9 2 GO:0060312 regulation of blood vessel remodeling 2/1165 11/18722 0.146661069530246 0.348192907768146 CST3/TGFB1 2 GO:0061029 eyelid development in camera-type eye 2/1165 11/18722 0.146661069530246 0.348192907768146 TFAP2A/HDAC2 2 GO:0070243 regulation of thymocyte apoptotic process 2/1165 11/18722 0.146661069530246 0.348192907768146 EFNA1/ADAM8 2 GO:0070778 L-aspartate transmembrane transport 2/1165 11/18722 0.146661069530246 0.348192907768146 SLC1A3/SLC25A13 2 GO:0071888 macrophage apoptotic process 2/1165 11/18722 0.146661069530246 0.348192907768146 CTSL/IRF7 2 GO:0072205 metanephric collecting duct development 2/1165 11/18722 0.146661069530246 0.348192907768146 DLG5/AKR1B1 2 GO:0090160 Golgi to lysosome transport 2/1165 11/18722 0.146661069530246 0.348192907768146 LAPTM5/CLN3 2 GO:0097048 dendritic cell apoptotic process 2/1165 11/18722 0.146661069530246 0.348192907768146 LILRB1/LYN 2 GO:0106049 regulation of cellular response to osmotic stress 2/1165 11/18722 0.146661069530246 0.348192907768146 BAD/CLN3 2 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/1165 11/18722 0.146661069530246 0.348192907768146 ATP2B4/GNAI2 2 GO:1900426 positive regulation of defense response to bacterium 2/1165 11/18722 0.146661069530246 0.348192907768146 CYBA/GRN 2 GO:1902337 regulation of apoptotic process involved in morphogenesis 2/1165 11/18722 0.146661069530246 0.348192907768146 BMP7/TNFRSF1B 2 GO:1902667 regulation of axon guidance 2/1165 11/18722 0.146661069530246 0.348192907768146 NRP1/VEGFA 2 GO:1903961 positive regulation of anion transmembrane transport 2/1165 11/18722 0.146661069530246 0.348192907768146 TCAF1/ITGB1 2 GO:1904321 response to forskolin 2/1165 11/18722 0.146661069530246 0.348192907768146 GNAI1/FDX1 2 GO:1904322 cellular response to forskolin 2/1165 11/18722 0.146661069530246 0.348192907768146 GNAI1/FDX1 2 GO:1905668 positive regulation of protein localization to endosome 2/1165 11/18722 0.146661069530246 0.348192907768146 MSN/SORL1 2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/1165 11/18722 0.146661069530246 0.348192907768146 CEBPB/HSPA5 2 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 2/1165 11/18722 0.146661069530246 0.348192907768146 CD74/LRP1 2 GO:2000392 regulation of lamellipodium morphogenesis 2/1165 11/18722 0.146661069530246 0.348192907768146 KANK1/CD44 2 GO:2000668 regulation of dendritic cell apoptotic process 2/1165 11/18722 0.146661069530246 0.348192907768146 LILRB1/LYN 2 GO:0001975 response to amphetamine 4/1165 33/18722 0.146698442408982 0.348192907768146 SOD1/HDAC2/RGS10/NR4A1 4 GO:0031116 positive regulation of microtubule polymerization 4/1165 33/18722 0.146698442408982 0.348192907768146 MET/CLIP1/AKAP9/RPS3 4 GO:0033198 response to ATP 4/1165 33/18722 0.146698442408982 0.348192907768146 HSPD1/SOD1/HSP90B1/SLC8A1 4 GO:0045920 negative regulation of exocytosis 4/1165 33/18722 0.146698442408982 0.348192907768146 HLA-F/SPI1/GNAI2/CD300A 4 GO:0046685 response to arsenic-containing substance 4/1165 33/18722 0.146698442408982 0.348192907768146 SERPINF1/VCP/DHX36/GSTO1 4 GO:0048333 mesodermal cell differentiation 4/1165 33/18722 0.146698442408982 0.348192907768146 ITGB4/GJA1/ITGB1/KLF4 4 GO:0061842 microtubule organizing center localization 4/1165 33/18722 0.146698442408982 0.348192907768146 SYNE2/ASPM/DLG1/AKAP9 4 GO:0071295 cellular response to vitamin 4/1165 33/18722 0.146698442408982 0.348192907768146 FOLR1/PTN/ATP2B1/MDM2 4 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 4/1165 33/18722 0.146698442408982 0.348192907768146 KANK1/TACSTD2/YAP1/ABI3 4 GO:1902692 regulation of neuroblast proliferation 4/1165 33/18722 0.146698442408982 0.348192907768146 GLI3/ASPM/PTN/VEGFA 4 GO:0018958 phenol-containing compound metabolic process 10/1165 110/18722 0.146708752337728 0.348192907768146 GATA3/EPAS1/COMT/AKR1B1/PNKD/OPN3/PARK7/GCH1/CGA/ZEB2 10 GO:1904064 positive regulation of cation transmembrane transport 13/1165 151/18722 0.147094465023299 0.348813363825845 CTSS/TMSB4X/ANK3/KCNN4/IFNGR2/SLC9A1/FLNA/AKAP9/GSTO1/TREM2/GLRX/VMP1/CXCL10 13 GO:2000181 negative regulation of blood vessel morphogenesis 13/1165 151/18722 0.147094465023299 0.348813363825845 SEMA6A/COL4A2/ADAMTS1/SERPINF1/AMOT/KLF2/PTN/STAT1/FOXO4/KLF4/ATP2B4/PGK1/CXCL10 13 GO:0006941 striated muscle contraction 15/1165 179/18722 0.148154112243729 0.351177800685833 GJA5/DSP/DSG2/GJA1/CXCR4/ALDOA/DSC2/SLC9A1/DLG1/FLNA/AKAP9/GSTO1/C12orf57/SLC8A1/NR4A1 15 GO:0035335 peptidyl-tyrosine dephosphorylation 9/1165 97/18722 0.149257963426213 0.353346667529031 PTPN14/DUSP5/DUSP14/DUSP1/PGP/PTPRC/PTPN6/PTPRA/PTP4A1 9 GO:0043255 regulation of carbohydrate biosynthetic process 9/1165 97/18722 0.149257963426213 0.353346667529031 SORBS1/SLC35B4/DDB1/FBP1/PGP/CLTC/TGFB1/IGF2/FAM3C 9 GO:0070252 actin-mediated cell contraction 9/1165 97/18722 0.149257963426213 0.353346667529031 GJA5/DSP/DSG2/GJA1/DSC2/SLC9A1/DLG1/FLNA/AKAP9 9 GO:0010508 positive regulation of autophagy 11/1165 124/18722 0.149422069312289 0.353586035012597 BNIP3L/SESN1/SCOC/SLC25A5/PIK3C2A/PARK7/TRIM22/BAD/UFL1/BNIP3/VDAC1 11 GO:0043525 positive regulation of neuron apoptotic process 6/1165 58/18722 0.150530570482306 0.355909053124339 TYROBP/TFAP2A/RHOA/FIS1/JUN/GRN 6 GO:2000649 regulation of sodium ion transmembrane transporter activity 6/1165 58/18722 0.150530570482306 0.355909053124339 FXYD3/ANK3/SLC9A1/FXYD5/GLRX/UTRN 6 GO:0006112 energy reserve metabolic process 8/1165 84/18722 0.151089305743785 0.356613959128496 PHLDA2/SORBS1/AGL/GFPT1/IL6ST/IGF2/PHKB/UGP2 8 GO:0010921 regulation of phosphatase activity 8/1165 84/18722 0.151089305743785 0.356613959128496 SLC39A10/HSP90B1/HSP90AB1/PTPRC/LGALS3/GNAI2/CD300A/JAK2 8 GO:0042310 vasoconstriction 8/1165 84/18722 0.151089305743785 0.356613959128496 EGFR/GJA5/SLC6A4/GJA1/ATP2B1/RHOA/PIK3C2A/SLC8A1 8 GO:0098586 cellular response to virus 8/1165 84/18722 0.151089305743785 0.356613959128496 HSP90AA1/IFI6/C1QBP/IRF7/OAS1/PHB/OASL/CXCL10 8 GO:0035107 appendage morphogenesis 12/1165 138/18722 0.151209909625124 0.356613959128496 FBN2/PBX1/BMP7/LRP5/FRAS1/TFAP2A/GLI3/GPC3/TBX3/DLX5/SOX4/HDAC2 12 GO:0035108 limb morphogenesis 12/1165 138/18722 0.151209909625124 0.356613959128496 FBN2/PBX1/BMP7/LRP5/FRAS1/TFAP2A/GLI3/GPC3/TBX3/DLX5/SOX4/HDAC2 12 GO:0003208 cardiac ventricle morphogenesis 7/1165 71/18722 0.151765252982465 0.357623159106035 LRP2/TGFBR3/DSP/ISL1/GATA3/SOX4/TGFB1 7 GO:0043550 regulation of lipid kinase activity 7/1165 71/18722 0.151765252982465 0.357623159106035 FLT1/VAV3/KLF4/TGFB1/FGR/SOCS3/LYN 7 GO:0030522 intracellular receptor signaling pathway 21/1165 265/18722 0.152167037020939 0.358410736331594 NR2F2/ISL1/PARP1/NR2F6/ESRRG/YAP1/KLF2/NFKBIA/SKP2/DAB2/RHOA/C1QBP/ESRRA/PARK7/IRF7/CALR/PHB/OASL/UFL1/JAK2/NR4A1 21 GO:0021915 neural tube development 13/1165 152/18722 0.152291039756076 0.358410736331594 LRP2/BMP7/SPINT1/SPINT2/FOLR1/LMO4/GLI3/PRKACB/SOX4/TGFB1/RPS7/VASP/ZFP36L1 13 GO:1901343 negative regulation of vasculature development 13/1165 152/18722 0.152291039756076 0.358410736331594 SEMA6A/COL4A2/ADAMTS1/SERPINF1/AMOT/KLF2/PTN/STAT1/FOXO4/KLF4/ATP2B4/PGK1/CXCL10 13 GO:0071867 response to monoamine 10/1165 111/18722 0.152851890437641 0.358678934540438 NSG1/APP/SLC9A1/GNAS/ID1/GNA11/TGM2/FLNA/ATP2B4/HDAC2 10 GO:0071869 response to catecholamine 10/1165 111/18722 0.152851890437641 0.358678934540438 NSG1/APP/SLC9A1/GNAS/ID1/GNA11/TGM2/FLNA/ATP2B4/HDAC2 10 GO:0010948 negative regulation of cell cycle process 23/1165 294/18722 0.152997339347311 0.358678934540438 BMP7/CTDSPL/WEE1/DUSP1/NPM1/DLG1/FOXO4/PRKDC/AURKAIP1/SOX4/ATF5/EIF2AK4/CCND1/KLF4/BRD7/MDM2/CENPF/USP47/NAA10/RAD21/BABAM1/ZFP36L1/CCNB1 23 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 3/1165 22/18722 0.153938634118638 0.358678934540438 SPESP1/FOLR1/CD9 3 GO:0016137 glycoside metabolic process 3/1165 22/18722 0.153938634118638 0.358678934540438 AKR1B1/FUCA1/FUCA2 3 GO:0032693 negative regulation of interleukin-10 production 3/1165 22/18722 0.153938634118638 0.358678934540438 TYROBP/LILRB4/LILRB1 3 GO:0032816 positive regulation of natural killer cell activation 3/1165 22/18722 0.153938634118638 0.358678934540438 TYROBP/HLA-E/HLA-F 3 GO:0033617 mitochondrial cytochrome c oxidase assembly 3/1165 22/18722 0.153938634118638 0.358678934540438 COA4/COX20/SCO2 3 GO:0034629 cellular protein-containing complex localization 3/1165 22/18722 0.153938634118638 0.358678934540438 DLG1/AKAP9/WASL 3 GO:0035561 regulation of chromatin binding 3/1165 22/18722 0.153938634118638 0.358678934540438 GMNN/MBD2/PARP9 3 GO:0035584 calcium-mediated signaling using intracellular calcium source 3/1165 22/18722 0.153938634118638 0.358678934540438 PTPRC/FIS1/DEFB1 3 GO:0048169 regulation of long-term neuronal synaptic plasticity 3/1165 22/18722 0.153938634118638 0.358678934540438 APP/HRAS/RAB11A 3 GO:0051151 negative regulation of smooth muscle cell differentiation 3/1165 22/18722 0.153938634118638 0.358678934540438 PDCD4/DNMT1/FOXO4 3 GO:0051220 cytoplasmic sequestering of protein 3/1165 22/18722 0.153938634118638 0.358678934540438 TMSB4X/NFKBIA/FLNA 3 GO:0051412 response to corticosterone 3/1165 22/18722 0.153938634118638 0.358678934540438 ATP2B1/FOS/CCND1 3 GO:0060343 trabecula formation 3/1165 22/18722 0.153938634118638 0.358678934540438 FBN2/TGFBR3/ADAMTS1 3 GO:0060965 negative regulation of gene silencing by miRNA 3/1165 22/18722 0.153938634118638 0.358678934540438 LIN28B/KCNQ1OT1/TGFB1 3 GO:0071359 cellular response to dsRNA 3/1165 22/18722 0.153938634118638 0.358678934540438 COLEC12/NPM1/IFIT1 3 GO:0072574 hepatocyte proliferation 3/1165 22/18722 0.153938634118638 0.358678934540438 PTN/CEBPB/SULF2 3 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 3/1165 22/18722 0.153938634118638 0.358678934540438 PTN/CEBPB/SULF2 3 GO:0099563 modification of synaptic structure 3/1165 22/18722 0.153938634118638 0.358678934540438 MYH10/RHOA/CLN3 3 GO:0140467 integrated stress response signaling 3/1165 22/18722 0.153938634118638 0.358678934540438 HSPA5/EIF2AK1/EIF2AK4 3 GO:1900120 regulation of receptor binding 3/1165 22/18722 0.153938634118638 0.358678934540438 B2M/PHLDA2/NRP1 3 GO:2000773 negative regulation of cellular senescence 3/1165 22/18722 0.153938634118638 0.358678934540438 CDK6/PRKDC/YBX1 3 GO:0043502 regulation of muscle adaptation 9/1165 98/18722 0.155901261474571 0.362622394835306 DAG1/PARP1/AIF1/SLC9A1/CAMK2G/KLF4/ATP2B4/IL6ST/TNFRSF1B 9 GO:0031648 protein destabilization 5/1165 46/18722 0.155954117429615 0.362622394835306 SIAH1/CTSH/PRKDC/MYLIP/MDM2 5 GO:0043616 keratinocyte proliferation 5/1165 46/18722 0.155954117429615 0.362622394835306 FERMT1/YAP1/ZFP36/IRF6/ZFP36L1 5 GO:0050919 negative chemotaxis 5/1165 46/18722 0.155954117429615 0.362622394835306 SEMA6A/SEMA6D/DPP4/NRP2/RHOA 5 GO:0055010 ventricular cardiac muscle tissue morphogenesis 5/1165 46/18722 0.155954117429615 0.362622394835306 LRP2/TGFBR3/DSP/ISL1/TGFB1 5 GO:0006066 alcohol metabolic process 27/1165 353/18722 0.156365536777224 0.363278045501059 ISYNA1/ACSS1/LRP5/APP/SOD1/DHCR24/LIMA1/PLPP3/FDFT1/ADH5/SLC5A3/NUDT4/APOE/IDH1/AKR1B1/TPI1/ALDH2/FDPS/PGP/PMVK/PARK7/FDX1/ACO2/GCH1/ACADVL/GK/APOBR 27 GO:0031346 positive regulation of cell projection organization 27/1165 353/18722 0.156365536777224 0.363278045501059 TENM3/BMP7/ITGA6/SERPINF1/OBSL1/NRP1/APOE/PTN/FNBP1L/GOLGA4/HSPA5/VEGFA/FLNA/SKIL/EPS8/DHX36/ATMIN/WASF2/HRAS/WASL/NME1/CREB3L2/RAB11A/SNX3/LRP1/GRN/LYN 27 GO:0051783 regulation of nuclear division 12/1165 139/18722 0.156755609781462 0.36403361096539 BMP7/LRP5/OBSL1/DUSP1/AURKAIP1/ANAPC11/MKI67/CENPF/CALR/IGF2/RAD21/CCNB1 12 GO:0061448 connective tissue development 20/1165 252/18722 0.157568139813243 0.365769217854315 EFEMP1/BMP7/LRP5/SERPINH1/TIMP1/CD44/GLI3/ARID5B/SCIN/ITGB8/UBB/SPI1/CRIP1/ESRRA/TGFB1/TYMS/PGRMC2/CREB3L2/SULF2/SORL1 20 GO:0097696 receptor signaling pathway via STAT 15/1165 181/18722 0.157778102796368 0.366052952759824 ISL1/PRLR/STAT1/AKR1B1/PTPRC/IL6ST/TGFB1/HDAC2/JAK1/SOCS3/PARP9/IL10RB/CD300A/JAK2/LYN 15 GO:0097006 regulation of plasma lipoprotein particle levels 8/1165 85/18722 0.158323201381503 0.366052952759824 APOE/LRPAP1/PRKACB/MYLIP/APOC1/TREM2/CNPY2/LIPA 8 GO:0001662 behavioral fear response 4/1165 34/18722 0.158603381634045 0.366052952759824 DPP4/GJA1/APOE/VDAC1 4 GO:0002183 cytoplasmic translational initiation 4/1165 34/18722 0.158603381634045 0.366052952759824 EIF3A/EIF2S2/EIF5/EIF3J 4 GO:0006356 regulation of transcription by RNA polymerase I 4/1165 34/18722 0.158603381634045 0.366052952759824 POLR2L/FLNA/POLR2K/NCL 4 GO:0014072 response to isoquinoline alkaloid 4/1165 34/18722 0.158603381634045 0.366052952759824 CXCR4/AIF1/MDM2/PEA15 4 GO:0019320 hexose catabolic process 4/1165 34/18722 0.158603381634045 0.366052952759824 LRP5/FUT8/ENO1/BAD 4 GO:0034383 low-density lipoprotein particle clearance 4/1165 34/18722 0.158603381634045 0.366052952759824 MYLIP/TREM2/CNPY2/LIPA 4 GO:0035308 negative regulation of protein dephosphorylation 4/1165 34/18722 0.158603381634045 0.366052952759824 LGALS3/GNAI2/YWHAE/ENSA 4 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 4/1165 34/18722 0.158603381634045 0.366052952759824 C1QBP/IRF7/PHB/OASL 4 GO:0043278 response to morphine 4/1165 34/18722 0.158603381634045 0.366052952759824 CXCR4/AIF1/MDM2/PEA15 4 GO:0070232 regulation of T cell apoptotic process 4/1165 34/18722 0.158603381634045 0.366052952759824 EFNA1/LGALS3/TSC22D3/ADAM8 4 GO:0070884 regulation of calcineurin-NFAT signaling cascade 4/1165 34/18722 0.158603381634045 0.366052952759824 SLC9A1/ATP2B4/CIB1/NFAT5 4 GO:2000758 positive regulation of peptidyl-lysine acetylation 4/1165 34/18722 0.158603381634045 0.366052952759824 ISL1/GATA3/SOX4/BRD7 4 GO:0048640 negative regulation of developmental growth 10/1165 112/18722 0.159122187401276 0.367099399047828 SEMA6A/SEMA6D/SLC6A4/ADRB1/GJA1/NRP1/LGMN/PLAC8/GDF15/CGA 10 GO:0030042 actin filament depolymerization 6/1165 59/18722 0.159363730765936 0.367203867319047 SCIN/DSTN/LIMA1/EPS8/TRIOBP/ADD3 6 GO:0033013 tetrapyrrole metabolic process 6/1165 59/18722 0.159363730765936 0.367203867319047 EIF2AK1/MTR/SLCO2B1/MMADHC/TSPO/UROD 6 GO:0051353 positive regulation of oxidoreductase activity 6/1165 59/18722 0.159363730765936 0.367203867319047 CYBA/APOE/PARK7/GNAI2/GCH1/NDUFA4 6 GO:0002534 cytokine production involved in inflammatory response 7/1165 72/18722 0.159712201982237 0.36725300685223 PDCD4/PYCARD/GBP5/TREM2/CHID1/GPSM3/LILRB4 7 GO:0005977 glycogen metabolic process 7/1165 72/18722 0.159712201982237 0.36725300685223 PHLDA2/SORBS1/AGL/IL6ST/IGF2/PHKB/UGP2 7 GO:0030330 DNA damage response, signal transduction by p53 class mediator 7/1165 72/18722 0.159712201982237 0.36725300685223 CD44/NPM1/PMAIP1/SOX4/CD74/SMYD2/MDM2 7 GO:0042246 tissue regeneration 7/1165 72/18722 0.159712201982237 0.36725300685223 DAG1/YAP1/KLF5/PTN/GPX1/CD9/CCNB1 7 GO:1900015 regulation of cytokine production involved in inflammatory response 7/1165 72/18722 0.159712201982237 0.36725300685223 PDCD4/PYCARD/GBP5/TREM2/CHID1/GPSM3/LILRB4 7 GO:0032412 regulation of ion transmembrane transporter activity 21/1165 267/18722 0.160128144805129 0.368058671904664 TCAF1/FXYD3/CTSS/APP/TMSB4X/ANK3/IFNGR2/SLC9A1/KCNG1/ITGB1/DLG1/FXYD5/C4orf3/AKAP9/GSTO1/TREM2/GLRX/VMP1/YWHAE/UTRN/NDUFA4 21 GO:0010717 regulation of epithelial to mesenchymal transition 9/1165 99/18722 0.162686068873777 0.373632121353728 BMP7/DAG1/ISL1/GATA3/FERMT2/EFNA1/DAB2/TGFB1/HDAC2 9 GO:0060996 dendritic spine development 9/1165 99/18722 0.162686068873777 0.373632121353728 DLG5/EFNA1/APOE/DHX36/HDAC2/ARF4/WASL/DOCK10/ABI3 9 GO:0008037 cell recognition 18/1165 225/18722 0.16459339177813 0.37673505661669 SPESP1/COLEC12/CXCR4/CADM1/APP/FOLR1/ALDOA/VCAN/FCN1/NRP1/BSG/DLG1/PECAM1/CCT2/LGALS3/CD9/MSN/TREM2 18 GO:0034103 regulation of tissue remodeling 8/1165 86/18722 0.165716904105834 0.37673505661669 EGFR/SYT7/TFRC/CST3/TGFB1/SUCO/SYK/ADAM8 8 GO:2001251 negative regulation of chromosome organization 8/1165 86/18722 0.165716904105834 0.37673505661669 PARP1/DUSP1/RAD50/CENPF/NAA10/RAD21/TOP2A/CCNB1 8 GO:0031641 regulation of myelination 5/1165 47/18722 0.166203953127758 0.37673505661669 TYMP/DAG1/PTN/DLG1/TNFRSF1B 5 GO:0035850 epithelial cell differentiation involved in kidney development 5/1165 47/18722 0.166203953127758 0.37673505661669 GATA3/CD24/YAP1/STAT1/BASP1 5 GO:0045911 positive regulation of DNA recombination 5/1165 47/18722 0.166203953127758 0.37673505661669 PARP1/TFRC/PTPRC/FUS/TGFB1 5 GO:0048483 autonomic nervous system development 5/1165 47/18722 0.166203953127758 0.37673505661669 NRP2/GATA3/TFAP2A/NRP1/SOX4 5 GO:0050798 activated T cell proliferation 5/1165 47/18722 0.166203953127758 0.37673505661669 CD24/PYCARD/LILRB4/IGF2/RPS3 5 GO:0050885 neuromuscular process controlling balance 5/1165 47/18722 0.166203953127758 0.37673505661669 IGDCC3/APP/MYO7A/SLC1A3/CLN3 5 GO:0051972 regulation of telomerase activity 5/1165 47/18722 0.166203953127758 0.37673505661669 PKIB/HSP90AB1/HSP90AA1/CCT2/KLF4 5 GO:0002637 regulation of immunoglobulin production 7/1165 73/18722 0.167843307918614 0.37673505661669 TFRC/HLA-E/PRKDC/PTPRC/CD86/TGFB1/PHB 7 GO:0006073 cellular glucan metabolic process 7/1165 73/18722 0.167843307918614 0.37673505661669 PHLDA2/SORBS1/AGL/IL6ST/IGF2/PHKB/UGP2 7 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 7/1165 73/18722 0.167843307918614 0.37673505661669 LRP5/MPC2/HLA-DRB1/HMGN3/CCDC186/BAD/LRP1 7 GO:0035924 cellular response to vascular endothelial growth factor stimulus 7/1165 73/18722 0.167843307918614 0.37673505661669 SEMA6A/NRP2/FLT1/NRP1/VEGFA/ATP2B4/NR4A1 7 GO:0044042 glucan metabolic process 7/1165 73/18722 0.167843307918614 0.37673505661669 PHLDA2/SORBS1/AGL/IL6ST/IGF2/PHKB/UGP2 7 GO:0045739 positive regulation of DNA repair 7/1165 73/18722 0.167843307918614 0.37673505661669 EGFR/PARP1/PRKDC/FUS/BABAM1/RPS3/PARP9 7 GO:0016241 regulation of macroautophagy 12/1165 141/18722 0.168154146090906 0.37673505661669 ATP6V1B1/ATP6V1C2/GAPDH/BNIP3L/SESN1/SCOC/SLC25A5/SNX6/CLN3/BNIP3/VDAC1/ATP6V1E1 12 GO:0006081 cellular aldehyde metabolic process 6/1165 60/18722 0.168415432011494 0.37673505661669 ALDH7A1/ADH5/IDH1/TPI1/PNKD/PARK7 6 GO:0006893 Golgi to plasma membrane transport 6/1165 60/18722 0.168415432011494 0.37673505661669 KRT18/ANK3/VAMP5/GOLGA4/RABEP1/CLN3 6 GO:0033866 nucleoside bisphosphate biosynthetic process 6/1165 60/18722 0.168415432011494 0.37673505661669 ACSS1/SLC26A2/MPC2/TECR/DLD/SLC25A1 6 GO:0034030 ribonucleoside bisphosphate biosynthetic process 6/1165 60/18722 0.168415432011494 0.37673505661669 ACSS1/SLC26A2/MPC2/TECR/DLD/SLC25A1 6 GO:0034033 purine nucleoside bisphosphate biosynthetic process 6/1165 60/18722 0.168415432011494 0.37673505661669 ACSS1/SLC26A2/MPC2/TECR/DLD/SLC25A1 6 GO:0046434 organophosphate catabolic process 13/1165 155/18722 0.168448035723447 0.37673505661669 TYMP/HINT1/NUDT4/IDH1/VCP/UPP1/APOC1/GPCPD1/PRDX6/NUDT5/DNPH1/PNP/DUT 13 GO:0000491 small nucleolar ribonucleoprotein complex assembly 2/1165 12/18722 0.169067144012269 0.37673505661669 SNU13/RUVBL1 2 GO:0002024 diet induced thermogenesis 2/1165 12/18722 0.169067144012269 0.37673505661669 ADRB1/SORL1 2 GO:0002328 pro-B cell differentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 PRKDC/SOX4 2 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 2/1165 12/18722 0.169067144012269 0.37673505661669 HLA-E/PARK7 2 GO:0002903 negative regulation of B cell apoptotic process 2/1165 12/18722 0.169067144012269 0.37673505661669 SLC39A10/CD74 2 GO:0006534 cysteine metabolic process 2/1165 12/18722 0.169067144012269 0.37673505661669 GCLM/CDO1 2 GO:0006703 estrogen biosynthetic process 2/1165 12/18722 0.169067144012269 0.37673505661669 HSD17B1/HSD17B11 2 GO:0007614 short-term memory 2/1165 12/18722 0.169067144012269 0.37673505661669 SERPINF1/COMT 2 GO:0009086 methionine biosynthetic process 2/1165 12/18722 0.169067144012269 0.37673505661669 ADI1/MTR 2 GO:0016554 cytidine to uridine editing 2/1165 12/18722 0.169067144012269 0.37673505661669 APOBEC3A/RBM47 2 GO:0032490 detection of molecule of bacterial origin 2/1165 12/18722 0.169067144012269 0.37673505661669 TREM2/TLR2 2 GO:0032621 interleukin-18 production 2/1165 12/18722 0.169067144012269 0.37673505661669 GBP5/TLR2 2 GO:0032661 regulation of interleukin-18 production 2/1165 12/18722 0.169067144012269 0.37673505661669 GBP5/TLR2 2 GO:0032908 regulation of transforming growth factor beta1 production 2/1165 12/18722 0.169067144012269 0.37673505661669 TYROBP/CD2AP 2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 2/1165 12/18722 0.169067144012269 0.37673505661669 COL4A2/SYK 2 GO:0042118 endothelial cell activation 2/1165 12/18722 0.169067144012269 0.37673505661669 PPIA/CXCL10 2 GO:0043696 dedifferentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 CDK6/NCOA3 2 GO:0043697 cell dedifferentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 CDK6/NCOA3 2 GO:0045602 negative regulation of endothelial cell differentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 ID1/VEGFA 2 GO:0046051 UTP metabolic process 2/1165 12/18722 0.169067144012269 0.37673505661669 AK3/NME1 2 GO:0051095 regulation of helicase activity 2/1165 12/18722 0.169067144012269 0.37673505661669 IFIT1/SSBP1 2 GO:0051340 regulation of ligase activity 2/1165 12/18722 0.169067144012269 0.37673505661669 TMSB4X/GCLM 2 GO:0060019 radial glial cell differentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 GLI3/RHOA 2 GO:0060788 ectodermal placode formation 2/1165 12/18722 0.169067144012269 0.37673505661669 TBX3/HDAC2 2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 2/1165 12/18722 0.169067144012269 0.37673505661669 GLI3/PRKACB 2 GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/1165 12/18722 0.169067144012269 0.37673505661669 BMP7/FOLR1 2 GO:0061308 cardiac neural crest cell development involved in heart development 2/1165 12/18722 0.169067144012269 0.37673505661669 BMP7/FOLR1 2 GO:0071287 cellular response to manganese ion 2/1165 12/18722 0.169067144012269 0.37673505661669 APP/HSPA5 2 GO:0071472 cellular response to salt stress 2/1165 12/18722 0.169067144012269 0.37673505661669 AKR1B1/ZFP36L1 2 GO:0071697 ectodermal placode morphogenesis 2/1165 12/18722 0.169067144012269 0.37673505661669 TBX3/HDAC2 2 GO:0071872 cellular response to epinephrine stimulus 2/1165 12/18722 0.169067144012269 0.37673505661669 SLC9A1/ATP2B4 2 GO:0072520 seminiferous tubule development 2/1165 12/18722 0.169067144012269 0.37673505661669 ADGRG1/UBB 2 GO:0090085 regulation of protein deubiquitination 2/1165 12/18722 0.169067144012269 0.37673505661669 VCP/PARK7 2 GO:0090385 phagosome-lysosome fusion 2/1165 12/18722 0.169067144012269 0.37673505661669 SYT7/CLN3 2 GO:0090677 reversible differentiation 2/1165 12/18722 0.169067144012269 0.37673505661669 SOD2/DNMT1 2 GO:0098974 postsynaptic actin cytoskeleton organization 2/1165 12/18722 0.169067144012269 0.37673505661669 WASF2/ACTB 2 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 2/1165 12/18722 0.169067144012269 0.37673505661669 CD68/TREM2 2 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 2/1165 12/18722 0.169067144012269 0.37673505661669 C4orf3/VMP1 2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/1165 12/18722 0.169067144012269 0.37673505661669 EGFR/TGFB1 2 GO:1904748 regulation of apoptotic process involved in development 2/1165 12/18722 0.169067144012269 0.37673505661669 BMP7/TNFRSF1B 2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 2/1165 12/18722 0.169067144012269 0.37673505661669 CCT2/GNL3 2 GO:1905666 regulation of protein localization to endosome 2/1165 12/18722 0.169067144012269 0.37673505661669 MSN/SORL1 2 GO:1990034 calcium ion export across plasma membrane 2/1165 12/18722 0.169067144012269 0.37673505661669 ATP2B1/YWHAE 2 GO:2000035 regulation of stem cell division 2/1165 12/18722 0.169067144012269 0.37673505661669 EVI2B/NCOA3 2 GO:2000105 positive regulation of DNA-dependent DNA replication 2/1165 12/18722 0.169067144012269 0.37673505661669 STOML2/SSBP1 2 GO:0002052 positive regulation of neuroblast proliferation 3/1165 23/18722 0.169339488302852 0.37673505661669 GLI3/ASPM/VEGFA 3 GO:0006541 glutamine metabolic process 3/1165 23/18722 0.169339488302852 0.37673505661669 GFPT1/ASNSD1/GLUL 3 GO:0006622 protein targeting to lysosome 3/1165 23/18722 0.169339488302852 0.37673505661669 LAPTM5/HSPA8/SORL1 3 GO:0030325 adrenal gland development 3/1165 23/18722 0.169339488302852 0.37673505661669 PBX1/ARID5B/TSPO 3 GO:0030539 male genitalia development 3/1165 23/18722 0.169339488302852 0.37673505661669 LGR4/DHCR24/TBX3 3 GO:0035162 embryonic hemopoiesis 3/1165 23/18722 0.169339488302852 0.37673505661669 PBX1/GATA3/VEGFA 3 GO:0035812 renal sodium excretion 3/1165 23/18722 0.169339488302852 0.37673505661669 ATP6V1B1/COMT/GNAI2 3 GO:0036303 lymph vessel morphogenesis 3/1165 23/18722 0.169339488302852 0.37673505661669 SVEP1/PTPN14/VEGFA 3 GO:0060384 innervation 3/1165 23/18722 0.169339488302852 0.37673505661669 ISL1/NRP1/SULF2 3 GO:0060396 growth hormone receptor signaling pathway 3/1165 23/18722 0.169339488302852 0.37673505661669 GDF15/JAK2/LYN 3 GO:0072576 liver morphogenesis 3/1165 23/18722 0.169339488302852 0.37673505661669 PTN/CEBPB/SULF2 3 GO:0002209 behavioral defense response 4/1165 35/18722 0.170849238166304 0.378294585336278 DPP4/GJA1/APOE/VDAC1 4 GO:0009119 ribonucleoside metabolic process 4/1165 35/18722 0.170849238166304 0.378294585336278 APOBEC3A/UPP1/ADK/PNP 4 GO:0010765 positive regulation of sodium ion transport 4/1165 35/18722 0.170849238166304 0.378294585336278 ANK3/PRSS8/SLC9A1/GLRX 4 GO:0032814 regulation of natural killer cell activation 4/1165 35/18722 0.170849238166304 0.378294585336278 TYROBP/HLA-E/HLA-F/FGR 4 GO:0033280 response to vitamin D 4/1165 35/18722 0.170849238166304 0.378294585336278 BMP7/PTN/ATP2B1/CXCL10 4 GO:0045907 positive regulation of vasoconstriction 4/1165 35/18722 0.170849238166304 0.378294585336278 EGFR/GJA5/GJA1/RHOA 4 GO:0070536 protein K63-linked deubiquitination 4/1165 35/18722 0.170849238166304 0.378294585336278 USP27X/PSMD14/VCP/BABAM1 4 GO:0072528 pyrimidine-containing compound biosynthetic process 4/1165 35/18722 0.170849238166304 0.378294585336278 UPP1/TYMS/NME1/DUT 4 GO:0086005 ventricular cardiac muscle cell action potential 4/1165 35/18722 0.170849238166304 0.378294585336278 DSP/DSG2/DSC2/DLG1 4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 4/1165 35/18722 0.170849238166304 0.378294585336278 NRP1/VEGFA/PIK3C2A/CIB1 4 GO:0098810 neurotransmitter reuptake 4/1165 35/18722 0.170849238166304 0.378294585336278 SLC6A4/ITGB1/SLC29A1/PARK7 4 GO:0106056 regulation of calcineurin-mediated signaling 4/1165 35/18722 0.170849238166304 0.378294585336278 SLC9A1/ATP2B4/CIB1/NFAT5 4 GO:1903008 organelle disassembly 10/1165 114/18722 0.172034390149099 0.380768545704612 BNIP3L/VCP/SLC25A5/PARK7/UFL1/FIS1/TSPO/BNIP3/VDAC1/GABARAPL1 10 GO:0007051 spindle organization 15/1165 184/18722 0.17281591401255 0.382347546453467 TACC2/ASPM/GNAI1/TUBB/DLG1/VCP/RHOA/FLNA/CLTC/RAN/STMN1/RAB11A/RPS3/SMC3/CCNB1 15 GO:0007259 receptor signaling pathway via JAK-STAT 14/1165 170/18722 0.173588577307917 0.383905707024955 ISL1/PRLR/STAT1/AKR1B1/PTPRC/IL6ST/HDAC2/JAK1/SOCS3/PARP9/IL10RB/CD300A/JAK2/LYN 14 GO:0030968 endoplasmic reticulum unfolded protein response 7/1165 74/18722 0.176152461142086 0.389116003302058 HSPA5/VCP/CCND1/SERP1/ERO1A/UFL1/CREB3L2 7 GO:0048332 mesoderm morphogenesis 7/1165 74/18722 0.176152461142086 0.389116003302058 ITGB4/BMP7/WLS/GJA1/TBX3/ITGB1/KLF4 7 GO:0070972 protein localization to endoplasmic reticulum 7/1165 74/18722 0.176152461142086 0.389116003302058 GJA1/HSPA5/GPAA1/SRPRB/SRP14/KDELR1/KDELR2 7 GO:0006111 regulation of gluconeogenesis 5/1165 48/18722 0.176711366964051 0.389737093426019 SLC35B4/DDB1/FBP1/PGP/FAM3C 5 GO:0035036 sperm-egg recognition 5/1165 48/18722 0.176711366964051 0.389737093426019 SPESP1/FOLR1/ALDOA/CCT2/CD9 5 GO:0045912 negative regulation of carbohydrate metabolic process 5/1165 48/18722 0.176711366964051 0.389737093426019 FBP1/PGP/CLTC/TGFB1/FAM3C 5 GO:0048146 positive regulation of fibroblast proliferation 5/1165 48/18722 0.176711366964051 0.389737093426019 CDK6/S100A6/PRKDC/CD74/CCNB1 5 GO:0043954 cellular component maintenance 6/1165 61/18722 0.177676756057499 0.391712345542318 TJP1/FERMT2/IGF1R/APOE/DLG1/TREM2 6 GO:0051052 regulation of DNA metabolic process 27/1165 359/18722 0.17781184986704 0.391856267492617 EGFR/GJA1/PKIB/GATA3/PARP1/TFRC/HSP90AB1/ANXA3/DUSP1/NPM1/HSP90AA1/MAGEF1/PRKDC/PTPRC/CCT2/DHX36/SPI1/KLF4/FUS/GNL3/RAD50/NUCKS1/TGFB1/MBD2/BABAM1/RPS3/PARP9 27 GO:0006874 cellular calcium ion homeostasis 33/1165 448/18722 0.178700161935095 0.393659344168636 GJA1/CXCR4/APP/CYBA/HSP90B1/CD24/APOE/ATP2B1/TGM2/PTPRC/CD55/AFG3L2/ATP2B4/PTPN6/CD52/STOML2/GSTO1/FPR1/CCDC47/FPR3/CALR/ERO1A/CXCL10/TMEM165/YWHAE/S1PR4/FIS1/CLN3/BNIP3/SLC8A1/LRP1/JAK2/LYN 33 GO:0023061 signal release 34/1165 463/18722 0.179126862220401 0.394444518494748 EGFR/DPP4/WLS/LRP5/SLC6A4/GJA1/ISL1/FAM3B/GATA3/SYT7/PTGES/TBX3/STXBP2/MPC2/HLA-DRB1/HMGN3/SOX4/PNKD/CAMK2G/SERP1/PARK7/UQCC2/CCDC186/RETN/BAD/LILRB1/GLUL/CGA/SYK/LRP1/JAK2/ENSA/LYN/NR4A1 34 GO:0007030 Golgi organization 13/1165 157/18722 0.179678154519728 0.395503326007542 LMAN1/OBSL1/GOLGB1/TMED4/TMED1/TMED9/TMED3/PDE4DIP/AKAP9/VMP1/ARL1/SURF4/RAB2A 13 GO:0062013 positive regulation of small molecule metabolic process 12/1165 143/18722 0.179950756032643 0.395948096280371 SORBS1/APP/TMSB4X/DDB1/COMT/PMAIP1/VCP/CD74/TREM2/PARK7/ENO1/IGF2 12 GO:0008217 regulation of blood pressure 15/1165 186/18722 0.183230071831078 0.401583034713758 NR2F2/GJA5/ENPEP/MME/LRP5/ADRB1/GJA1/SOD2/SOD1/CYBA/ADH5/ATP2B1/RHOA/ANPEP/GCH1 15 GO:0120032 regulation of plasma membrane bounded cell projection assembly 15/1165 186/18722 0.183230071831078 0.401583034713758 KANK1/TACSTD2/YAP1/NRP1/KLF5/SH3YL1/FNBP1L/EPS8/ATMIN/WASF2/HRAS/WASL/RHOG/CLN3/ABI3 15 GO:0006631 fatty acid metabolic process 29/1165 390/18722 0.183249631609308 0.401583034713758 SLC27A2/ACSS1/HACD3/ATP6V1B1/PTGES/ECHDC2/ADH5/MGLL/ECHS1/AKR1B1/DEGS1/GPX1/PCCB/HPGD/AIG1/GSTP1/ECI1/ECI2/NDUFAB1/APOC1/TECR/CD74/ETFA/DLD/GPX4/ECH1/HADHB/ACADVL/ECHDC1 29 GO:0042593 glucose homeostasis 20/1165 258/18722 0.183318083990126 0.401583034713758 LRP5/FAM3B/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/NUCKS1/SLC29A1/TREM2/PARK7/CCDC186/OAS1/BAD/NME1/FIS1/LRP1 20 GO:0003203 endocardial cushion morphogenesis 4/1165 36/18722 0.183410997102083 0.401583034713758 BMP7/ISL1/TBX3/MDM2 4 GO:0003230 cardiac atrium development 4/1165 36/18722 0.183410997102083 0.401583034713758 GJA5/ISL1/SOX4/MDM2 4 GO:0010762 regulation of fibroblast migration 4/1165 36/18722 0.183410997102083 0.401583034713758 ITGB1/TGFB1/CLN3/SLC8A1 4 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 4/1165 36/18722 0.183410997102083 0.401583034713758 MPC2/HLA-DRB1/BAD/LRP1 4 GO:0045652 regulation of megakaryocyte differentiation 4/1165 36/18722 0.183410997102083 0.401583034713758 SCIN/PITHD1/CIB1/PRMT1 4 GO:0062014 negative regulation of small molecule metabolic process 9/1165 102/18722 0.183856366842719 0.401583034713758 PARP1/SOD1/APOE/FBP1/PGP/APOC1/ATP2B4/FAM3C/ACADVL 9 GO:0006278 RNA-dependent DNA biosynthetic process 7/1165 75/18722 0.184633267040692 0.401583034713758 PKIB/HSP90AB1/HSP90AA1/CCT2/RAD50/RFC1/NHP2 7 GO:0001783 B cell apoptotic process 3/1165 24/18722 0.185158897886906 0.401583034713758 SLC39A10/CD74/LYN 3 GO:0002438 acute inflammatory response to antigenic stimulus 3/1165 24/18722 0.185158897886906 0.401583034713758 GATA3/HLA-E/PARK7 3 GO:0002922 positive regulation of humoral immune response 3/1165 24/18722 0.185158897886906 0.401583034713758 PTPRC/TREM2/PHB 3 GO:0003181 atrioventricular valve morphogenesis 3/1165 24/18722 0.185158897886906 0.401583034713758 EFNA1/SOX4/MDM2 3 GO:0006213 pyrimidine nucleoside metabolic process 3/1165 24/18722 0.185158897886906 0.401583034713758 TYMP/APOBEC3A/UPP1 3 GO:0007035 vacuolar acidification 3/1165 24/18722 0.185158897886906 0.401583034713758 SLC11A1/CLN3/GRN 3 GO:0010155 regulation of proton transport 3/1165 24/18722 0.185158897886906 0.401583034713758 TMSB4X/PARK7/NDUFA4 3 GO:0010288 response to lead ion 3/1165 24/18722 0.185158897886906 0.401583034713758 APP/DNMT3A/PLSCR1 3 GO:0016486 peptide hormone processing 3/1165 24/18722 0.185158897886906 0.401583034713758 ENPEP/MME/CTSL 3 GO:0021801 cerebral cortex radial glia-guided migration 3/1165 24/18722 0.185158897886906 0.401583034713758 ADGRG1/LAMB1/GLI3 3 GO:0022030 telencephalon glial cell migration 3/1165 24/18722 0.185158897886906 0.401583034713758 ADGRG1/LAMB1/GLI3 3 GO:0030859 polarized epithelial cell differentiation 3/1165 24/18722 0.185158897886906 0.401583034713758 DLG5/RHOA/MSN 3 GO:0031639 plasminogen activation 3/1165 24/18722 0.185158897886906 0.401583034713758 DHCR24/PGK1/ENO1 3 GO:0032528 microvillus organization 3/1165 24/18722 0.185158897886906 0.401583034713758 KLF5/FXYD5/STK26 3 GO:0036010 protein localization to endosome 3/1165 24/18722 0.185158897886906 0.401583034713758 NRP1/MSN/SORL1 3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 3/1165 24/18722 0.185158897886906 0.401583034713758 GATA3/GPC1/SULF2 3 GO:0043302 positive regulation of leukocyte degranulation 3/1165 24/18722 0.185158897886906 0.401583034713758 HLA-F/FGR/SYK 3 GO:0050687 negative regulation of defense response to virus 3/1165 24/18722 0.185158897886906 0.401583034713758 FGL2/HTRA1/C1QBP 3 GO:0050855 regulation of B cell receptor signaling pathway 3/1165 24/18722 0.185158897886906 0.401583034713758 SLC39A10/CD300A/LYN 3 GO:0060149 negative regulation of posttranscriptional gene silencing 3/1165 24/18722 0.185158897886906 0.401583034713758 LIN28B/KCNQ1OT1/TGFB1 3 GO:0060967 negative regulation of gene silencing by RNA 3/1165 24/18722 0.185158897886906 0.401583034713758 LIN28B/KCNQ1OT1/TGFB1 3 GO:0070129 regulation of mitochondrial translation 3/1165 24/18722 0.185158897886906 0.401583034713758 C1QBP/LRPPRC/UQCC2 3 GO:0070841 inclusion body assembly 3/1165 24/18722 0.185158897886906 0.401583034713758 VCP/PSMC6/SORL1 3 GO:0071378 cellular response to growth hormone stimulus 3/1165 24/18722 0.185158897886906 0.401583034713758 GDF15/JAK2/LYN 3 GO:0071577 zinc ion transmembrane transport 3/1165 24/18722 0.185158897886906 0.401583034713758 SLC39A10/SLC39A1/SLC39A7 3 GO:0072010 glomerular epithelium development 3/1165 24/18722 0.185158897886906 0.401583034713758 CD24/PECAM1/BASP1 3 GO:0033559 unsaturated fatty acid metabolic process 10/1165 116/18722 0.185424132836701 0.401852273910658 ATP6V1B1/PTGES/MGLL/AKR1B1/DEGS1/GPX1/HPGD/GSTP1/CD74/GPX4 10 GO:0043488 regulation of mRNA stability 13/1165 158/18722 0.185426222951827 0.401852273910658 NPM1/ZFP36/VIM/DHX36/FUS/SLC11A1/SERBP1/CARHSP1/PABPC1/YBX1/APEX1/ZFP36L1/CIRBP 13 GO:0007612 learning 12/1165 144/18722 0.185993675334961 0.402926476130891 APP/COMT/ITGB1/PTN/LGMN/FOS/EIF2AK4/ARF4/TLR2/CLN3/JUN/VDAC1 12 GO:0006473 protein acetylation 16/1165 201/18722 0.186859399840254 0.404079868250296 ISL1/GATA3/MORF4L2/SOX4/HINT2/SPI1/USP22/RUVBL1/BRD7/NCOA3/PARK7/HDAC2/MORF4L1/NAA10/SET/PHF20 16 GO:0007588 excretion 6/1165 62/18722 0.187138422960823 0.404079868250296 ATP6V1B1/COMT/NFAT5/GNAI2/CLN3/AQP9 6 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 6/1165 62/18722 0.187138422960823 0.404079868250296 BMP7/RBPMS/DAB2/TGFB1/GDF15/LRP1 6 GO:0006953 acute-phase response 5/1165 49/18722 0.187461959188272 0.404079868250296 SERPINA1/PTGES/ASS1/CEBPB/PLSCR1 5 GO:0010823 negative regulation of mitochondrion organization 5/1165 49/18722 0.187461959188272 0.404079868250296 TFRC/GPX1/SLC25A5/TSPO/BNIP3 5 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 5/1165 49/18722 0.187461959188272 0.404079868250296 BMP7/RBPMS/DAB2/TGFB1/GDF15 5 GO:0035088 establishment or maintenance of apical/basal cell polarity 5/1165 49/18722 0.187461959188272 0.404079868250296 DLG5/DLG1/RHOA/MSN/ARF4 5 GO:0038084 vascular endothelial growth factor signaling pathway 5/1165 49/18722 0.187461959188272 0.404079868250296 SEMA6A/NRP2/FLT1/NRP1/VEGFA 5 GO:0043330 response to exogenous dsRNA 5/1165 49/18722 0.187461959188272 0.404079868250296 COLEC12/NFKBIA/DHX36/DDX1/IFIT1 5 GO:0048168 regulation of neuronal synaptic plasticity 5/1165 49/18722 0.187461959188272 0.404079868250296 APP/APOE/HRAS/CLN3/RAB11A 5 GO:0060964 regulation of gene silencing by miRNA 5/1165 49/18722 0.187461959188272 0.404079868250296 EGFR/LIN28B/KCNQ1OT1/ZFP36/TGFB1 5 GO:0060986 endocrine hormone secretion 5/1165 49/18722 0.187461959188272 0.404079868250296 GJA1/GATA3/TBX3/RETN/CGA 5 GO:0061245 establishment or maintenance of bipolar cell polarity 5/1165 49/18722 0.187461959188272 0.404079868250296 DLG5/DLG1/RHOA/MSN/ARF4 5 GO:0033500 carbohydrate homeostasis 20/1165 259/18722 0.18780839104104 0.404671208795915 LRP5/FAM3B/SERPINF1/CYBA/IGF1R/MPC2/GCLM/HLA-DRB1/HMGN3/SOX4/NUCKS1/SLC29A1/TREM2/PARK7/CCDC186/OAS1/BAD/NME1/FIS1/LRP1 20 GO:0006936 muscle contraction 26/1165 347/18722 0.188180877290281 0.405318213442191 GJA5/DSP/DSG2/GJA1/CALD1/CXCR4/ALDOA/DSC2/SOD1/TBX3/SLC9A1/ATP2B1/DLG1/RHOA/ASPH/FLNA/PIK3C2A/ATP2B4/AKAP9/GSTO1/ENO1/C12orf57/SLC8A1/UTRN/SULF2/NR4A1 26 GO:0033044 regulation of chromosome organization 15/1165 187/18722 0.188550310026829 0.405958147365015 PKIB/PARP1/DUSP1/DNMT1/CCT2/DHX36/GNL3/RAD50/ANAPC11/CENPF/NAA10/SSBP1/RAD21/TOP2A/CCNB1 15 GO:0002430 complement receptor mediated signaling pathway 2/1165 13/18722 0.191990775843728 0.40649360181063 FPR1/FPR3 2 GO:0006264 mitochondrial DNA replication 2/1165 13/18722 0.191990775843728 0.40649360181063 STOML2/SSBP1 2 GO:0006586 indolalkylamine metabolic process 2/1165 13/18722 0.191990775843728 0.40649360181063 IL4I1/KYNU 2 GO:0006983 ER overload response 2/1165 13/18722 0.191990775843728 0.40649360181063 HSPA5/CCDC47 2 GO:0007494 midgut development 2/1165 13/18722 0.191990775843728 0.40649360181063 EGFR/ASS1 2 GO:0010635 regulation of mitochondrial fusion 2/1165 13/18722 0.191990775843728 0.40649360181063 TFRC/BNIP3 2 GO:0010958 regulation of amino acid import across plasma membrane 2/1165 13/18722 0.191990775843728 0.40649360181063 ITGB1/ARL6IP5 2 GO:0010960 magnesium ion homeostasis 2/1165 13/18722 0.191990775843728 0.40649360181063 EGFR/ANK3 2 GO:0014745 negative regulation of muscle adaptation 2/1165 13/18722 0.191990775843728 0.40649360181063 KLF4/ATP2B4 2 GO:0015791 polyol transport 2/1165 13/18722 0.191990775843728 0.40649360181063 SLC5A3/AQP9 2 GO:0016322 neuron remodeling 2/1165 13/18722 0.191990775843728 0.40649360181063 APP/C1QA 2 GO:0021514 ventral spinal cord interneuron differentiation 2/1165 13/18722 0.191990775843728 0.40649360181063 LMO4/GLI3 2 GO:0021794 thalamus development 2/1165 13/18722 0.191990775843728 0.40649360181063 UQCRQ/PTN 2 GO:0021819 layer formation in cerebral cortex 2/1165 13/18722 0.191990775843728 0.40649360181063 ADGRG1/GLI3 2 GO:0030497 fatty acid elongation 2/1165 13/18722 0.191990775843728 0.40649360181063 HACD3/TECR 2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 2/1165 13/18722 0.191990775843728 0.40649360181063 PRDX2/LILRA2 2 GO:0032429 regulation of phospholipase A2 activity 2/1165 13/18722 0.191990775843728 0.40649360181063 EGFR/LRP1 2 GO:0032905 transforming growth factor beta1 production 2/1165 13/18722 0.191990775843728 0.40649360181063 TYROBP/CD2AP 2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 2/1165 13/18722 0.191990775843728 0.40649360181063 BRD4/EAPP 2 GO:0033700 phospholipid efflux 2/1165 13/18722 0.191990775843728 0.40649360181063 APOE/APOC1 2 GO:0036005 response to macrophage colony-stimulating factor 2/1165 13/18722 0.191990775843728 0.40649360181063 TREM2/TLR2 2 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 2/1165 13/18722 0.191990775843728 0.40649360181063 TREM2/TLR2 2 GO:0042659 regulation of cell fate specification 2/1165 13/18722 0.191990775843728 0.40649360181063 ESRP1/LMO4 2 GO:0042761 very long-chain fatty acid biosynthetic process 2/1165 13/18722 0.191990775843728 0.40649360181063 HACD3/TECR 2 GO:0046415 urate metabolic process 2/1165 13/18722 0.191990775843728 0.40649360181063 SLC22A11/PNP 2 GO:0048207 vesicle targeting, rough ER to cis-Golgi 2/1165 13/18722 0.191990775843728 0.40649360181063 TFG/PDCD6 2 GO:0048208 COPII vesicle coating 2/1165 13/18722 0.191990775843728 0.40649360181063 TFG/PDCD6 2 GO:0048266 behavioral response to pain 2/1165 13/18722 0.191990775843728 0.40649360181063 VWA1/TSPO 2 GO:0051451 myoblast migration 2/1165 13/18722 0.191990775843728 0.40649360181063 NET1/PLEKHO1 2 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1165 13/18722 0.191990775843728 0.40649360181063 ZFP36/PABPC1 2 GO:0060347 heart trabecula formation 2/1165 13/18722 0.191990775843728 0.40649360181063 TGFBR3/ADAMTS1 2 GO:0060707 trophoblast giant cell differentiation 2/1165 13/18722 0.191990775843728 0.40649360181063 NR2F2/SOCS3 2 GO:0061000 negative regulation of dendritic spine development 2/1165 13/18722 0.191990775843728 0.40649360181063 EFNA1/HDAC2 2 GO:0061744 motor behavior 2/1165 13/18722 0.191990775843728 0.40649360181063 DPP4/C12orf57 2 GO:0070254 mucus secretion 2/1165 13/18722 0.191990775843728 0.40649360181063 EGFR/CYBA 2 GO:0072672 neutrophil extravasation 2/1165 13/18722 0.191990775843728 0.40649360181063 PECAM1/ADAM8 2 GO:0090042 tubulin deacetylation 2/1165 13/18722 0.191990775843728 0.40649360181063 BEX4/FLNA 2 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/1165 13/18722 0.191990775843728 0.40649360181063 ATP2B4/GNAI2 2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 2/1165 13/18722 0.191990775843728 0.40649360181063 NRP2/NRP1 2 GO:1903789 regulation of amino acid transmembrane transport 2/1165 13/18722 0.191990775843728 0.40649360181063 ITGB1/ARL6IP5 2 GO:1903977 positive regulation of glial cell migration 2/1165 13/18722 0.191990775843728 0.40649360181063 TREM2/LRP1 2 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 2/1165 13/18722 0.191990775843728 0.40649360181063 PDCD4/DNMT1 2 GO:1905244 regulation of modification of synaptic structure 2/1165 13/18722 0.191990775843728 0.40649360181063 RHOA/CLN3 2 GO:0019722 calcium-mediated signaling 16/1165 202/18722 0.192027404299964 0.40649360181063 EGFR/CXCR4/SLC9A1/NUDT4/GBP1/PTPRC/ATP2B4/CIB1/GSTO1/TREM2/NFAT5/CCL4/FIS1/DEFB1/SLC8A1/SYK 16 GO:0043087 regulation of GTPase activity 26/1165 348/18722 0.192097114376215 0.40649360181063 MET/ITGA6/ADRB1/SYDE2/DOCK9/AMOT/SOD1/RASA1/FERMT2/S100A10/NET1/ITGB1/TGM2/VAV3/CCL3L3/PYCARD/LIMS1/TRAPPC6A/EIF5/HRAS/STMN1/DOCK10/RGS10/CCL4/RHOG/IQGAP2 26 GO:0051961 negative regulation of nervous system development 12/1165 145/18722 0.192130327027187 0.40649360181063 SEMA6A/SEMA6D/BMP7/B2M/NRP1/PTN/ID1/TREM2/PCM1/TLR2/TSPO/SORL1 12 GO:0006260 DNA replication 20/1165 260/18722 0.192353664609463 0.406812780502229 EGFR/RBBP7/MCM3/NASP/PTMS/MCM6/CCNE1/MCM7/ORC6/NUCKS1/STOML2/RPA3/HRAS/RFC1/SET/SSBP1/GMNN/JUN/DUT/SMC3 20 GO:0006305 DNA alkylation 7/1165 76/18722 0.193279069393835 0.408154784239125 PARP1/HELLS/DNMT1/FOS/DNMT3A/SPI1/MBD2 7 GO:0006306 DNA methylation 7/1165 76/18722 0.193279069393835 0.408154784239125 PARP1/HELLS/DNMT1/FOS/DNMT3A/SPI1/MBD2 7 GO:0021536 diencephalon development 7/1165 76/18722 0.193279069393835 0.408154784239125 CDH1/ISL1/NRP2/UQCRQ/NRP1/PTN/UBB 7 GO:0140115 export across plasma membrane 7/1165 76/18722 0.193279069393835 0.408154784239125 GJA1/SLC40A1/SLC9A1/ATP2B1/DLG1/YWHAE/SLC8A1 7 GO:0060491 regulation of cell projection assembly 15/1165 188/18722 0.193944281991507 0.409405511402155 KANK1/TACSTD2/YAP1/NRP1/KLF5/SH3YL1/FNBP1L/EPS8/ATMIN/WASF2/HRAS/WASL/RHOG/CLN3/ABI3 15 GO:0048639 positive regulation of developmental growth 14/1165 174/18722 0.195681609020745 0.412903246119859 TGFBR3/CXCR4/YAP1/NRP1/GOLGA4/PPIB/PRKDC/VEGFA/SERP1/BASP1/IGF2/RAB11A/LRP1/CCNB1 14 GO:0001990 regulation of systemic arterial blood pressure by hormone 4/1165 37/18722 0.196263292472436 0.412903246119859 ENPEP/MME/CYBA/RHOA 4 GO:0003176 aortic valve development 4/1165 37/18722 0.196263292472436 0.412903246119859 GATA3/EFNA1/TGFB1/TNFRSF1B 4 GO:0031112 positive regulation of microtubule polymerization or depolymerization 4/1165 37/18722 0.196263292472436 0.412903246119859 MET/CLIP1/AKAP9/RPS3 4 GO:0032885 regulation of polysaccharide biosynthetic process 4/1165 37/18722 0.196263292472436 0.412903246119859 SORBS1/CLTC/TGFB1/IGF2 4 GO:0043403 skeletal muscle tissue regeneration 4/1165 37/18722 0.196263292472436 0.412903246119859 DAG1/KLF5/GPX1/CD9 4 GO:0060306 regulation of membrane repolarization 4/1165 37/18722 0.196263292472436 0.412903246119859 GJA5/FLNA/AKAP9/YWHAE 4 GO:0060416 response to growth hormone 4/1165 37/18722 0.196263292472436 0.412903246119859 ASS1/GDF15/JAK2/LYN 4 GO:0072529 pyrimidine-containing compound catabolic process 4/1165 37/18722 0.196263292472436 0.412903246119859 TYMP/APOBEC3A/UPP1/DUT 4 GO:0016239 positive regulation of macroautophagy 6/1165 63/18722 0.196790831916516 0.413410409339518 BNIP3L/SESN1/SCOC/SLC25A5/BNIP3/VDAC1 6 GO:0032233 positive regulation of actin filament bundle assembly 6/1165 63/18722 0.196790831916516 0.413410409339518 FERMT2/S100A10/NRP1/ID1/RHOA/FLNA 6 GO:1902373 negative regulation of mRNA catabolic process 6/1165 63/18722 0.196790831916516 0.413410409339518 ZFP36/FUS/SLC11A1/PABPC1/YBX1/CIRBP 6 GO:0042475 odontogenesis of dentin-containing tooth 8/1165 90/18722 0.196798969135078 0.413410409339518 LAMA5/BMP7/PERP/GLI3/BSG/HTRA1/HDAC2/CSF3R 8 GO:0006475 internal protein amino acid acetylation 13/1165 160/18722 0.197179857625913 0.414055570839599 ISL1/GATA3/MORF4L2/SPI1/USP22/RUVBL1/BRD7/NCOA3/PARK7/MORF4L1/NAA10/SET/PHF20 13 GO:0016042 lipid catabolic process 24/1165 320/18722 0.198238901022436 0.415925709527309 SLC27A2/ECHDC2/MGLL/APOE/ECHS1/IDH1/PCCB/FUCA1/HINT2/AIG1/ECI1/ECI2/APOC1/ETFA/GPCPD1/ECH1/HSD17B11/PRDX6/HADHB/LIPA/LRP1/SORL1/ACADVL/ECHDC1 24 GO:0030490 maturation of SSU-rRNA 5/1165 50/18722 0.198440949601663 0.415925709527309 RPS21/RPS28/SNU13/RPS14/RPS16 5 GO:0043268 positive regulation of potassium ion transport 5/1165 50/18722 0.198440949601663 0.415925709527309 KCNN4/DLG1/FLNA/AKAP9/TREM2 5 GO:0045814 negative regulation of gene expression, epigenetic 5/1165 50/18722 0.198440949601663 0.415925709527309 HELLS/DNMT1/DNMT3A/SPI1/MBD2 5 GO:0060688 regulation of morphogenesis of a branching structure 5/1165 50/18722 0.198440949601663 0.415925709527309 MAGED1/BMP7/LGR4/TACSTD2/VEGFA 5 GO:0032963 collagen metabolic process 9/1165 104/18722 0.198613533526394 0.416132050647126 CTSL/SERPINH1/CTSS/ITGB1/VIM/CST3/TGFB1/HDAC2/SUCO 9 GO:0007613 memory 10/1165 118/18722 0.199267937018146 0.417191693578088 SLC6A4/SERPINF1/PRKCZ/APOE/COMT/PTN/CEBPB/LGMN/EIF2AK4/TREM2 10 GO:1903313 positive regulation of mRNA metabolic process 10/1165 118/18722 0.199267937018146 0.417191693578088 ZFP36/DHX36/PABPC1/PRDX6/NCL/ZFP36L1/RBM3/HSPA8/CIRBP/CCNB1 10 GO:0010954 positive regulation of protein processing 3/1165 25/18722 0.201343954128175 0.419348279970853 BAG2/ENO1/ADAM8 3 GO:0030318 melanocyte differentiation 3/1165 25/18722 0.201343954128175 0.419348279970853 GLI3/GNA11/ZEB2 3 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 3/1165 25/18722 0.201343954128175 0.419348279970853 PRDX2/CD55/LILRA2 3 GO:0033622 integrin activation 3/1165 25/18722 0.201343954128175 0.419348279970853 FERMT1/JAM3/FERMT2 3 GO:0062009 secondary palate development 3/1165 25/18722 0.201343954128175 0.419348279970853 TGFBR3/ITGB8/DLG1 3 GO:0072202 cell differentiation involved in metanephros development 3/1165 25/18722 0.201343954128175 0.419348279970853 LGR4/YAP1/STAT1 3 GO:0072207 metanephric epithelium development 3/1165 25/18722 0.201343954128175 0.419348279970853 LGR4/YAP1/STAT1 3 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 3/1165 25/18722 0.201343954128175 0.419348279970853 GJA5/GJA1/SLC8A1 3 GO:0090382 phagosome maturation 3/1165 25/18722 0.201343954128175 0.419348279970853 SYT7/MYO7A/CLN3 3 GO:0140448 signaling receptor ligand precursor processing 3/1165 25/18722 0.201343954128175 0.419348279970853 ENPEP/MME/CTSL 3 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 3/1165 25/18722 0.201343954128175 0.419348279970853 EGFR/LIN28B/TGFB1 3 GO:1903959 regulation of anion transmembrane transport 3/1165 25/18722 0.201343954128175 0.419348279970853 TCAF1/ITGB1/ARL6IP5 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/1165 25/18722 0.201343954128175 0.419348279970853 ADAMTS1/MDM2/LRP1 3 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 3/1165 25/18722 0.201343954128175 0.419348279970853 RHOA/ST3GAL4/NFAT5 3 GO:0031016 pancreas development 7/1165 77/18722 0.202082973837479 0.420575354894242 MET/WLS/ISL1/CDK6/SOX4/IGF2/BAD 7 GO:0048644 muscle organ morphogenesis 7/1165 77/18722 0.202082973837479 0.420575354894242 LRP2/TGFBR3/DSP/ISL1/ARID5B/SERP1/TGFB1 7 GO:0051650 establishment of vesicle localization 13/1165 161/18722 0.203181786855598 0.422705474284831 PRKCZ/MYO7A/FNBP1L/AP1M2/TFG/TMED9/CCDC186/MYO1G/WASL/CLN3/RAB11A/PDCD6/MYO1F 13 GO:1903531 negative regulation of secretion by cell 12/1165 147/18722 0.204676257983692 0.425656849226551 GJA1/FRMD4A/APOE/HLA-F/PNKD/SPI1/RSAD2/LILRB1/GNAI2/ERP29/CD300A/TNFRSF1B 12 GO:0002065 columnar/cuboidal epithelial cell differentiation 8/1165 91/18722 0.204921751360659 0.42585182909566 CDK6/YAP1/KLF5/CEBPB/SOX4/IL6ST/BAD/TYMS 8 GO:0055006 cardiac cell development 8/1165 91/18722 0.204921751360659 0.42585182909566 TGFBR3/ISL1/OBSL1/TBX3/PDCD4/VEGFA/SLC8A1/CCNB1 8 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 11/1165 133/18722 0.205781864888779 0.427480979874433 LAPTM5/MAGEF1/VCP/DAB2/BAG2/PSMC1/PSMC3/PSMC6/MDM2/TREM2/PSMC4 11 GO:0010906 regulation of glucose metabolic process 10/1165 119/18722 0.206352210049018 0.428437784539675 PHLDA2/SORBS1/SLC35B4/DDB1/FBP1/PMAIP1/PGP/IGF2/BAD/FAM3C 10 GO:0001885 endothelial cell development 6/1165 64/18722 0.206624101683396 0.428437784539675 MET/TJP1/GPX1/PECAM1/VEGFA/MSN 6 GO:0048857 neural nucleus development 6/1165 64/18722 0.206624101683396 0.428437784539675 HSPA5/RHOA/BASP1/YWHAE/ACTB/NDUFS3 6 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 6/1165 64/18722 0.206624101683396 0.428437784539675 LRP5/MPC2/HLA-DRB1/HMGN3/BAD/LRP1 6 GO:0070542 response to fatty acid 6/1165 64/18722 0.206624101683396 0.428437784539675 GLDC/ASS1/BAD/TLR2/NME1/CCNB1 6 GO:0007265 Ras protein signal transduction 25/1165 337/18722 0.20750625737055 0.430108058574926 ADGRG1/KANK1/MET/HACD3/DHCR24/CTNNAL1/RASA1/NRP1/AIF1/NET1/APOE/ITGB1/FBP1/DNMT1/RHOA/EPS8/GRB2/WASF2/PARK7/ARHGDIB/HRAS/STMN1/RRAS/RHOG/JUN 25 GO:0001825 blastocyst formation 4/1165 38/18722 0.20938056818997 0.432123191741292 YAP1/SKIL/JUNB/SF3B6 4 GO:0007007 inner mitochondrial membrane organization 4/1165 38/18722 0.20938056818997 0.432123191741292 AFG3L2/TIMM13/ROMO1/TIMM8B 4 GO:0032373 positive regulation of sterol transport 4/1165 38/18722 0.20938056818997 0.432123191741292 NFKBIA/APOE/TREM2/LRP1 4 GO:0032376 positive regulation of cholesterol transport 4/1165 38/18722 0.20938056818997 0.432123191741292 NFKBIA/APOE/TREM2/LRP1 4 GO:0035886 vascular associated smooth muscle cell differentiation 4/1165 38/18722 0.20938056818997 0.432123191741292 SOD2/PDCD4/DNMT1/VEGFA 4 GO:0042491 inner ear auditory receptor cell differentiation 4/1165 38/18722 0.20938056818997 0.432123191741292 ESRP1/SOD1/MYO7A/TRIOBP 4 GO:0072524 pyridine-containing compound metabolic process 4/1165 38/18722 0.20938056818997 0.432123191741292 QPRT/KYNU/PARP9/PNP 4 GO:0098926 postsynaptic signal transduction 4/1165 38/18722 0.20938056818997 0.432123191741292 GNA11/RGS10/GNAI2/JAK2 4 GO:0099622 cardiac muscle cell membrane repolarization 4/1165 38/18722 0.20938056818997 0.432123191741292 GJA5/FLNA/AKAP9/YWHAE 4 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 4/1165 38/18722 0.20938056818997 0.432123191741292 BNIP3L/SLC25A5/NMT1/BNIP3 4 GO:1901988 negative regulation of cell cycle phase transition 19/1165 249/18722 0.20944024795929 0.432123191741292 CTDSPL/WEE1/DUSP1/DLG1/FOXO4/PRKDC/SOX4/ATF5/EIF2AK4/CCND1/KLF4/BRD7/MDM2/CENPF/USP47/RAD21/BABAM1/ZFP36L1/CCNB1 19 GO:0032964 collagen biosynthetic process 5/1165 51/18722 0.209633253360331 0.432123191741292 SERPINH1/VIM/TGFB1/HDAC2/SUCO 5 GO:0045104 intermediate filament cytoskeleton organization 5/1165 51/18722 0.209633253360331 0.432123191741292 DSP/KRT18/SOD1/VIM/DST 5 GO:0045661 regulation of myoblast differentiation 5/1165 51/18722 0.209633253360331 0.432123191741292 MBNL3/TBX3/TGFB1/CXCL10/ZFP36L1 5 GO:0048013 ephrin receptor signaling pathway 5/1165 51/18722 0.209633253360331 0.432123191741292 EPHB4/RASA1/EFNA1/YES1/LYN 5 GO:0032147 activation of protein kinase activity 11/1165 134/18722 0.212551465733577 0.43585279937601 PRKCZ/PRLR/DLG1/VEGFA/CD86/SLC11A1/PARK7/PHB/PPIA/CD300A/JAK2 11 GO:0031058 positive regulation of histone modification 8/1165 92/18722 0.213174964893334 0.43585279937601 ISL1/GATA3/BRD4/DNMT1/VEGFA/BRD7/RTF1/CCNB1 8 GO:1903312 negative regulation of mRNA metabolic process 8/1165 92/18722 0.213174964893334 0.43585279937601 NPM1/ZFP36/C1QBP/FUS/SLC11A1/PABPC1/YBX1/CIRBP 8 GO:0006304 DNA modification 10/1165 120/18722 0.213540278984758 0.43585279937601 GATA3/PARP1/APOBEC3A/HELLS/DNMT1/FOS/DNMT3A/SPI1/APEX1/MBD2 10 GO:0048593 camera-type eye morphogenesis 10/1165 120/18722 0.213540278984758 0.43585279937601 TENM3/BMP7/LRP5/TFAP2A/GLI3/OBSL1/PTN/VEGFA/C12orf57/HMGN1 10 GO:0000054 ribosomal subunit export from nucleus 2/1165 14/18722 0.215280968502752 0.43585279937601 NPM1/RAN 2 GO:0002864 regulation of acute inflammatory response to antigenic stimulus 2/1165 14/18722 0.215280968502752 0.43585279937601 HLA-E/PARK7 2 GO:0003188 heart valve formation 2/1165 14/18722 0.215280968502752 0.43585279937601 GJA5/EFNA1 2 GO:0006047 UDP-N-acetylglucosamine metabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 GFPT1/MGAT1 2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 2/1165 14/18722 0.215280968502752 0.43585279937601 VPS25/SNX6 2 GO:0009158 ribonucleoside monophosphate catabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 UPP1/PNP 2 GO:0010872 regulation of cholesterol esterification 2/1165 14/18722 0.215280968502752 0.43585279937601 APOE/APOC1 2 GO:0018158 protein oxidation 2/1165 14/18722 0.215280968502752 0.43585279937601 GPX1/PRDX3 2 GO:0030213 hyaluronan biosynthetic process 2/1165 14/18722 0.215280968502752 0.43585279937601 CLTC/TGFB1 2 GO:0032688 negative regulation of interferon-beta production 2/1165 14/18722 0.215280968502752 0.43585279937601 PYCARD/LILRB1 2 GO:0033008 positive regulation of mast cell activation involved in immune response 2/1165 14/18722 0.215280968502752 0.43585279937601 FGR/SYK 2 GO:0033750 ribosome localization 2/1165 14/18722 0.215280968502752 0.43585279937601 NPM1/RAN 2 GO:0035641 locomotory exploration behavior 2/1165 14/18722 0.215280968502752 0.43585279937601 DPP4/APOE 2 GO:0035672 oligopeptide transmembrane transport 2/1165 14/18722 0.215280968502752 0.43585279937601 GJA1/SLC13A3 2 GO:0036444 calcium import into the mitochondrion 2/1165 14/18722 0.215280968502752 0.43585279937601 AFG3L2/VDAC1 2 GO:0042921 glucocorticoid receptor signaling pathway 2/1165 14/18722 0.215280968502752 0.43585279937601 CALR/PHB 2 GO:0043173 nucleotide salvage 2/1165 14/18722 0.215280968502752 0.43585279937601 UPP1/ADK 2 GO:0043249 erythrocyte maturation 2/1165 14/18722 0.215280968502752 0.43585279937601 KLF2/FAM210B 2 GO:0043306 positive regulation of mast cell degranulation 2/1165 14/18722 0.215280968502752 0.43585279937601 FGR/SYK 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/1165 14/18722 0.215280968502752 0.43585279937601 IRF1/LILRB4 2 GO:0043455 regulation of secondary metabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 OPN3/ZEB2 2 GO:0045059 positive thymic T cell selection 2/1165 14/18722 0.215280968502752 0.43585279937601 PTPRC/CD74 2 GO:0045579 positive regulation of B cell differentiation 2/1165 14/18722 0.215280968502752 0.43585279937601 BAD/SYK 2 GO:0046131 pyrimidine ribonucleoside metabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 APOBEC3A/UPP1 2 GO:0046133 pyrimidine ribonucleoside catabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 APOBEC3A/UPP1 2 GO:0046348 amino sugar catabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 MGAT1/NPL 2 GO:0046655 folic acid metabolic process 2/1165 14/18722 0.215280968502752 0.43585279937601 FOLR1/SLC19A1 2 GO:0047484 regulation of response to osmotic stress 2/1165 14/18722 0.215280968502752 0.43585279937601 BAD/CLN3 2 GO:0048021 regulation of melanin biosynthetic process 2/1165 14/18722 0.215280968502752 0.43585279937601 OPN3/ZEB2 2 GO:0048291 isotype switching to IgG isotypes 2/1165 14/18722 0.215280968502752 0.43585279937601 HSPD1/PTPRC 2 GO:0060911 cardiac cell fate commitment 2/1165 14/18722 0.215280968502752 0.43585279937601 ISL1/TBX3 2 GO:0071285 cellular response to lithium ion 2/1165 14/18722 0.215280968502752 0.43585279937601 CDH1/CALR 2 GO:0071481 cellular response to X-ray 2/1165 14/18722 0.215280968502752 0.43585279937601 GATA3/NUCKS1 2 GO:0072176 nephric duct development 2/1165 14/18722 0.215280968502752 0.43585279937601 GATA3/GPC3 2 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 2/1165 14/18722 0.215280968502752 0.43585279937601 ATP2B4/GNAI2 2 GO:0099188 postsynaptic cytoskeleton organization 2/1165 14/18722 0.215280968502752 0.43585279937601 WASF2/ACTB 2 GO:0099638 endosome to plasma membrane protein transport 2/1165 14/18722 0.215280968502752 0.43585279937601 NSG1/RAB11A 2 GO:1900376 regulation of secondary metabolite biosynthetic process 2/1165 14/18722 0.215280968502752 0.43585279937601 OPN3/ZEB2 2 GO:1901722 regulation of cell proliferation involved in kidney development 2/1165 14/18722 0.215280968502752 0.43585279937601 BMP7/GATA3 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/1165 14/18722 0.215280968502752 0.43585279937601 CD44/CD74 2 GO:1902969 mitotic DNA replication 2/1165 14/18722 0.215280968502752 0.43585279937601 MCM3/MCM6 2 GO:1903894 regulation of IRE1-mediated unfolded protein response 2/1165 14/18722 0.215280968502752 0.43585279937601 HSPA5/UFL1 2 GO:1904814 regulation of protein localization to chromosome, telomeric region 2/1165 14/18722 0.215280968502752 0.43585279937601 CCT2/GNL3 2 GO:2001140 positive regulation of phospholipid transport 2/1165 14/18722 0.215280968502752 0.43585279937601 DBI/APOE 2 GO:0008544 epidermis development 24/1165 324/18722 0.215325104697965 0.43585279937601 SVEP1/LAMA5/EGFR/LGR5/DSP/LGR4/FERMT1/EXPH5/ESRP1/SOD1/YAP1/MYO7A/ZFP36/IRF6/HLA-DRB1/KLF4/TXNIP/OPN3/NCOA3/TRIOBP/HDAC2/YBX1/CST6/ZFP36L1 24 GO:0035418 protein localization to synapse 6/1165 65/18722 0.216628110332968 0.437792000375176 DAG1/NSG1/PRKCZ/DLG1/HRAS/RAB11A 6 GO:0070613 regulation of protein processing 6/1165 65/18722 0.216628110332968 0.437792000375176 BAG2/PRKACB/MDM2/ENO1/CLN3/ADAM8 6 GO:0001558 regulation of cell growth 30/1165 414/18722 0.21735498222129 0.437792000375176 SEMA6A/EGFR/SEMA6D/GJA1/CXCR4/CYBA/RBBP7/NRP1/SLC9A1/NET1/EI24/NPM1/APOE/FBP1/GOLGA4/SMARCA2/S100A8/RHOA/VEGFA/CIB1/TGFB1/ENO1/USP47/PHB/CXCL16/BST2/DNPH1/RAB11A/NDUFS3/LRP1 30 GO:0001963 synaptic transmission, dopaminergic 3/1165 26/18722 0.217843053099567 0.437792000375176 SLC6A4/PNKD/PARK7 3 GO:0006027 glycosaminoglycan catabolic process 3/1165 26/18722 0.217843053099567 0.437792000375176 CD44/FUCA1/TGFB1 3 GO:0008535 respiratory chain complex IV assembly 3/1165 26/18722 0.217843053099567 0.437792000375176 COA4/COX20/SCO2 3 GO:0009164 nucleoside catabolic process 3/1165 26/18722 0.217843053099567 0.437792000375176 APOBEC3A/UPP1/PNP 3 GO:0009435 NAD biosynthetic process 3/1165 26/18722 0.217843053099567 0.437792000375176 QPRT/KYNU/PARP9 3 GO:0034063 stress granule assembly 3/1165 26/18722 0.217843053099567 0.437792000375176 RPS23/PRRC2C/CIRBP 3 GO:0034114 regulation of heterotypic cell-cell adhesion 3/1165 26/18722 0.217843053099567 0.437792000375176 BMP7/CD44/KLF4 3 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 3/1165 26/18722 0.217843053099567 0.437792000375176 UBB/ARMCX3/LRPPRC 3 GO:0042278 purine nucleoside metabolic process 3/1165 26/18722 0.217843053099567 0.437792000375176 ADK/OARD1/PNP 3 GO:0045026 plasma membrane fusion 3/1165 26/18722 0.217843053099567 0.437792000375176 SPESP1/FOLR1/CD9 3 GO:0045672 positive regulation of osteoclast differentiation 3/1165 26/18722 0.217843053099567 0.437792000375176 TYROBP/FOS/TREM2 3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 3/1165 26/18722 0.217843053099567 0.437792000375176 CADM1/HLA-E/HLA-F 3 GO:0047497 mitochondrion transport along microtubule 3/1165 26/18722 0.217843053099567 0.437792000375176 UBB/ARMCX3/LRPPRC 3 GO:0048843 negative regulation of axon extension involved in axon guidance 3/1165 26/18722 0.217843053099567 0.437792000375176 SEMA6A/SEMA6D/NRP1 3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 3/1165 26/18722 0.217843053099567 0.437792000375176 EGFR/LIN28B/TGFB1 3 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 3/1165 26/18722 0.217843053099567 0.437792000375176 ADRB1/ATP2B4/GNAI2 3 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 3/1165 26/18722 0.217843053099567 0.437792000375176 SOD2/PDCD4/DNMT1 3 GO:0042157 lipoprotein metabolic process 11/1165 135/18722 0.219412831213551 0.440788912527437 NOTUM/OLR1/PGAP2/DBI/APOE/GPAA1/APOC1/NMT1/GLUL/APOL6/LRP1 11 GO:0000245 spliceosomal complex assembly 7/1165 79/18722 0.220136461534832 0.441768308400076 SNRPG/DDX1/SNRPD1/SNRPE/SNRPD2/SF1/SNRPC 7 GO:0006446 regulation of translational initiation 7/1165 79/18722 0.220136461534832 0.441768308400076 NPM1/EIF2AK1/EIF2AK4/DDX1/EIF1/EIF5/EIF5B 7 GO:1901184 regulation of ERBB signaling pathway 7/1165 79/18722 0.220136461534832 0.441768308400076 EGFR/NCF1/LGMN/IFI6/PLAUR/VPS25/SNX6 7 GO:0043244 regulation of protein-containing complex disassembly 10/1165 121/18722 0.220828669289892 0.442441229281147 SCIN/DSTN/IGF1R/LIMA1/EPS8/CIB1/TRIOBP/ADD3/CLN3/BNIP3 10 GO:0043500 muscle adaptation 10/1165 121/18722 0.220828669289892 0.442441229281147 DAG1/PARP1/CYBA/AIF1/SLC9A1/CAMK2G/KLF4/ATP2B4/IL6ST/TNFRSF1B 10 GO:1904019 epithelial cell apoptotic process 10/1165 121/18722 0.220828669289892 0.442441229281147 KRT18/KRT8/GATA3/YAP1/PDCD4/ZFP36/DNMT3A/BAD/ZFP36L1/JAK2 10 GO:0032206 positive regulation of telomere maintenance 5/1165 52/18722 0.221023553697548 0.442441229281147 PKIB/CCT2/DHX36/GNL3/RAD50 5 GO:0045103 intermediate filament-based process 5/1165 52/18722 0.221023553697548 0.442441229281147 DSP/KRT18/SOD1/VIM/DST 5 GO:0048260 positive regulation of receptor-mediated endocytosis 5/1165 52/18722 0.221023553697548 0.442441229281147 B2M/DAB2/VEGFA/WASL/SYK 5 GO:0060147 regulation of posttranscriptional gene silencing 5/1165 52/18722 0.221023553697548 0.442441229281147 EGFR/LIN28B/KCNQ1OT1/ZFP36/TGFB1 5 GO:0032088 negative regulation of NF-kappaB transcription factor activity 8/1165 93/18722 0.221553085448537 0.443092577785215 BMP7/TMSB4X/PRDX2/NFKBIA/SPI1/KLF4/PYCARD/UFL1 8 GO:0005976 polysaccharide metabolic process 9/1165 107/18722 0.221635134033456 0.443092577785215 PHLDA2/SORBS1/AGL/CLTC/IL6ST/TGFB1/IGF2/PHKB/UGP2 9 GO:0036503 ERAD pathway 9/1165 107/18722 0.221635134033456 0.443092577785215 HSP90B1/HSPA5/VCP/UBE4B/PSMC6/USP14/CCDC47/CALR/UBXN4 9 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 13/1165 164/18722 0.221664699522695 0.443092577785215 LAPTM5/HSP90AB1/RPL23/MAGEF1/VCP/DAB2/RPL5/MDM2/USP14/PARK7/RAD23B/RPS7/UFL1 13 GO:0031507 heterochromatin assembly 4/1165 39/18722 0.222737226065519 0.44460314719266 HELLS/DNMT1/DNMT3A/MBD2 4 GO:0042417 dopamine metabolic process 4/1165 39/18722 0.222737226065519 0.44460314719266 COMT/PNKD/PARK7/GCH1 4 GO:0045622 regulation of T-helper cell differentiation 4/1165 39/18722 0.222737226065519 0.44460314719266 PRKCZ/HLA-DRA/HLA-DRB1/CD86 4 GO:1902742 apoptotic process involved in development 4/1165 39/18722 0.222737226065519 0.44460314719266 BMP7/LRP5/SPI1/TNFRSF1B 4 GO:1901617 organic hydroxy compound biosynthetic process 18/1165 237/18722 0.222888063215665 0.444746071393363 HSD17B1/SLC27A2/ISYNA1/GATA3/SOD1/DHCR24/FDFT1/APOE/AKR1B1/FDPS/PGP/OSBPL9/OPN3/PMVK/PARK7/CYB5R1/GCH1/ZEB2 18 GO:0050918 positive chemotaxis 6/1165 66/18722 0.226792534157596 0.452376152887912 MET/NRP1/VEGFA/LGALS3/CXCL10/LRP1 6 GO:0051208 sequestering of calcium ion 10/1165 122/18722 0.228213806095548 0.4550494115859 CYBA/HSP90B1/PTPRC/PTPN6/GSTO1/CALR/ERO1A/CXCL10/SLC8A1/LYN 10 GO:0007422 peripheral nervous system development 7/1165 80/18722 0.22937127597199 0.457194947454112 ITGB4/DAG1/ISL1/SOD1/GPC1/ERBB3/SLC5A3 7 GO:0001738 morphogenesis of a polarized epithelium 8/1165 94/18722 0.230050448635509 0.458385931200252 LAMA5/DLG5/ZNRF3/GPC3/DAB2/RHOA/MSN/ACTB 8 GO:0030902 hindbrain development 12/1165 151/18722 0.230794022145937 0.459704345743487 BMP7/WLS/SLC6A4/UQCRQ/AIF1/ITGB1/PTN/HSPA5/FLNA/ATF5/ATIC/PSMG1 12 GO:0015698 inorganic anion transport 14/1165 180/18722 0.231100647230877 0.459988628690395 SLC26A2/CLDN4/SLC22A11/SLC13A4/FXYD3/CLIC3/GABRE/SLC25A3/CEBPB/SLC5A6/SLC11A1/SLC1A3/TSPO/VDAC1 14 GO:0071897 DNA biosynthetic process 14/1165 180/18722 0.231100647230877 0.459988628690395 GJA1/PKIB/HSP90AB1/DUSP1/HSP90AA1/VCP/CCT2/KLF4/RAD50/CENPF/RFC1/NHP2/PHB/TYMS 14 GO:0045806 negative regulation of endocytosis 5/1165 53/18722 0.232596371345113 0.461095273296665 LRPAP1/LGALS3/APOC1/LILRB1/CD300A 5 GO:0060966 regulation of gene silencing by RNA 5/1165 53/18722 0.232596371345113 0.461095273296665 EGFR/LIN28B/KCNQ1OT1/ZFP36/TGFB1 5 GO:1990090 cellular response to nerve growth factor stimulus 5/1165 53/18722 0.232596371345113 0.461095273296665 APP/ID1/HSPA5/ARPC3/CIB1 5 GO:0055123 digestive system development 11/1165 137/18722 0.233399044120044 0.461095273296665 EGFR/WLS/LGR4/GLI3/ASS1/YAP1/KLF5/IL6ST/IGF2/TYMS/CCNB1 11 GO:0061013 regulation of mRNA catabolic process 13/1165 166/18722 0.234363483555937 0.461095273296665 NPM1/ZFP36/VIM/DHX36/FUS/SLC11A1/SERBP1/CARHSP1/PABPC1/YBX1/APEX1/ZFP36L1/CIRBP 13 GO:0009651 response to salt stress 3/1165 27/18722 0.234606164717635 0.461095273296665 HSP90AB1/AKR1B1/ZFP36L1 3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/1165 27/18722 0.234606164717635 0.461095273296665 SLC9A1/GSTO1/SLC8A1 3 GO:0032786 positive regulation of DNA-templated transcription, elongation 3/1165 27/18722 0.234606164717635 0.461095273296665 BRD4/EAPP/HMGN1 3 GO:0033688 regulation of osteoblast proliferation 3/1165 27/18722 0.234606164717635 0.461095273296665 LRP5/RHOA/ATRAID 3 GO:0034143 regulation of toll-like receptor 4 signaling pathway 3/1165 27/18722 0.234606164717635 0.461095273296665 TREM2/LILRA2/LYN 3 GO:0034377 plasma lipoprotein particle assembly 3/1165 27/18722 0.234606164717635 0.461095273296665 APOE/PRKACB/APOC1 3 GO:0034698 response to gonadotropin 3/1165 27/18722 0.234606164717635 0.461095273296665 TGFBR3/CTSV/GCLM 3 GO:0039529 RIG-I signaling pathway 3/1165 27/18722 0.234606164717635 0.461095273296665 C1QBP/PHB/OASL 3 GO:0045830 positive regulation of isotype switching 3/1165 27/18722 0.234606164717635 0.461095273296665 TFRC/PTPRC/TGFB1 3 GO:0061437 renal system vasculature development 3/1165 27/18722 0.234606164717635 0.461095273296665 BMP7/NRP1/PECAM1 3 GO:0061440 kidney vasculature development 3/1165 27/18722 0.234606164717635 0.461095273296665 BMP7/NRP1/PECAM1 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/1165 27/18722 0.234606164717635 0.461095273296665 PARP1/TREM2/PARK7 3 GO:0009069 serine family amino acid metabolic process 4/1165 40/18722 0.236307761092193 0.461095273296665 GLDC/GCSH/GCLM/CDO1 4 GO:0030866 cortical actin cytoskeleton organization 4/1165 40/18722 0.236307761092193 0.461095273296665 LCP1/DLG1/CALR/FMNL1 4 GO:0045022 early endosome to late endosome transport 4/1165 40/18722 0.236307761092193 0.461095273296665 DAB2/FLNA/MSN/SNX3 4 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 4/1165 40/18722 0.236307761092193 0.461095273296665 DUSP1/CENPF/RAD21/CCNB1 4 GO:0150077 regulation of neuroinflammatory response 4/1165 40/18722 0.236307761092193 0.461095273296665 PTPRC/TREM2/TNFRSF1B/GRN 4 GO:1901998 toxin transport 4/1165 40/18722 0.236307761092193 0.461095273296665 NRP1/HSPA5/CCT2/BNIP3 4 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 4/1165 40/18722 0.236307761092193 0.461095273296665 BNIP3L/SLC25A5/NMT1/BNIP3 4 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 4/1165 40/18722 0.236307761092193 0.461095273296665 RHOA/KLF4/ST3GAL4/NFAT5 4 GO:2000142 regulation of DNA-templated transcription, initiation 4/1165 40/18722 0.236307761092193 0.461095273296665 DHX36/PSMC6/BCLAF1/JUN 4 GO:2000781 positive regulation of double-strand break repair 4/1165 40/18722 0.236307761092193 0.461095273296665 PARP1/PRKDC/FUS/PARP9 4 GO:0006879 cellular iron ion homeostasis 6/1165 67/18722 0.237106885591606 0.461095273296665 FTH1/SLC40A1/TFRC/SOD1/SLC11A1/ISCU 6 GO:0016445 somatic diversification of immunoglobulins 6/1165 67/18722 0.237106885591606 0.461095273296665 HSPD1/TFRC/PRKDC/PTPRC/TGFB1/CTNNBL1 6 GO:0043967 histone H4 acetylation 6/1165 67/18722 0.237106885591606 0.461095273296665 MORF4L2/SPI1/USP22/RUVBL1/MORF4L1/PHF20 6 GO:0072665 protein localization to vacuole 6/1165 67/18722 0.237106885591606 0.461095273296665 LAPTM5/GBP1/VPS25/LAMTOR5/HSPA8/SORL1 6 GO:0006605 protein targeting 23/1165 314/18722 0.237346905460684 0.461095273296665 TCAF1/ANK3/HSPD1/LMAN1/LAPTM5/NCF1/BNIP3L/HSP90AA1/HSPA5/AP1M2/SRPRB/PMPCB/SIL1/TIMM13/CIB1/SRP14/HRAS/ROMO1/FIS1/TSPO/TIMM8B/HSPA8/SORL1 23 GO:0016573 histone acetylation 12/1165 152/18722 0.237522849207926 0.461095273296665 ISL1/GATA3/MORF4L2/SPI1/USP22/RUVBL1/BRD7/NCOA3/PARK7/MORF4L1/SET/PHF20 12 GO:0031056 regulation of histone modification 12/1165 152/18722 0.237522849207926 0.461095273296665 ISL1/GATA3/BRD4/DNMT1/VEGFA/SPI1/BRD7/PARK7/RTF1/IGF2/SET/CCNB1 12 GO:0043266 regulation of potassium ion transport 9/1165 109/18722 0.237523039203682 0.461095273296665 ANK3/KCNN4/KCNG1/ITGB1/DLG1/FLNA/AKAP9/TREM2/YWHAE 9 GO:0030516 regulation of axon extension 8/1165 95/18722 0.238661264778381 0.461095273296665 SEMA6A/SEMA6D/NRP1/APOE/GOLGA4/VEGFA/RAB11A/LRP1 8 GO:0021954 central nervous system neuron development 7/1165 81/18722 0.238734700939109 0.461095273296665 NRP2/UQCRQ/HSP90AB1/NRP1/HSP90AA1/UBB/C12orf57 7 GO:1903533 regulation of protein targeting 7/1165 81/18722 0.238734700939109 0.461095273296665 TCAF1/ANK3/LMAN1/BNIP3L/CIB1/HRAS/FIS1 7 GO:2000243 positive regulation of reproductive process 7/1165 81/18722 0.238734700939109 0.461095273296665 VEGFA/C1QBP/CIB1/RETN/HDAC2/DEFB1/LHFPL2 7 GO:0002836 positive regulation of response to tumor cell 2/1165 15/18722 0.238803484673687 0.461095273296665 HSPD1/HLA-DRB1 2 GO:0002839 positive regulation of immune response to tumor cell 2/1165 15/18722 0.238803484673687 0.461095273296665 HSPD1/HLA-DRB1 2 GO:0006271 DNA strand elongation involved in DNA replication 2/1165 15/18722 0.238803484673687 0.461095273296665 MCM3/MCM7 2 GO:0006878 cellular copper ion homeostasis 2/1165 15/18722 0.238803484673687 0.461095273296665 APP/SCO2 2 GO:0009163 nucleoside biosynthetic process 2/1165 15/18722 0.238803484673687 0.461095273296665 ADK/PNP 2 GO:0010452 histone H3-K36 methylation 2/1165 15/18722 0.238803484673687 0.461095273296665 BRD4/SMYD2 2 GO:0010889 regulation of sequestering of triglyceride 2/1165 15/18722 0.238803484673687 0.461095273296665 PLIN2/TREM2 2 GO:0030852 regulation of granulocyte differentiation 2/1165 15/18722 0.238803484673687 0.461095273296665 C1QC/EVI2B 2 GO:0032354 response to follicle-stimulating hormone 2/1165 15/18722 0.238803484673687 0.461095273296665 TGFBR3/GCLM 2 GO:0032488 Cdc42 protein signal transduction 2/1165 15/18722 0.238803484673687 0.461095273296665 NRP1/APOE 2 GO:0032897 negative regulation of viral transcription 2/1165 15/18722 0.238803484673687 0.461095273296665 IFITM3/ZFP36 2 GO:0034380 high-density lipoprotein particle assembly 2/1165 15/18722 0.238803484673687 0.461095273296665 APOE/PRKACB 2 GO:0034384 high-density lipoprotein particle clearance 2/1165 15/18722 0.238803484673687 0.461095273296665 APOE/TREM2 2 GO:0034404 nucleobase-containing small molecule biosynthetic process 2/1165 15/18722 0.238803484673687 0.461095273296665 ADK/PNP 2 GO:0036376 sodium ion export across plasma membrane 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC9A1/SLC8A1 2 GO:0042159 lipoprotein catabolic process 2/1165 15/18722 0.238803484673687 0.461095273296665 NOTUM/APOE 2 GO:0042559 pteridine-containing compound biosynthetic process 2/1165 15/18722 0.238803484673687 0.461095273296665 ATIC/GCH1 2 GO:0042994 cytoplasmic sequestering of transcription factor 2/1165 15/18722 0.238803484673687 0.461095273296665 TMSB4X/NFKBIA 2 GO:0043508 negative regulation of JUN kinase activity 2/1165 15/18722 0.238803484673687 0.461095273296665 PDCD4/GSTP1 2 GO:0043584 nose development 2/1165 15/18722 0.238803484673687 0.461095273296665 GLI3/DLX5 2 GO:0045217 cell-cell junction maintenance 2/1165 15/18722 0.238803484673687 0.461095273296665 TJP1/FERMT2 2 GO:0045725 positive regulation of glycogen biosynthetic process 2/1165 15/18722 0.238803484673687 0.461095273296665 SORBS1/IGF2 2 GO:0046459 short-chain fatty acid metabolic process 2/1165 15/18722 0.238803484673687 0.461095273296665 ACSS1/PCCB 2 GO:0051775 response to redox state 2/1165 15/18722 0.238803484673687 0.461095273296665 ADH5/ARHGDIB 2 GO:0060099 regulation of phagocytosis, engulfment 2/1165 15/18722 0.238803484673687 0.461095273296665 TREM2/CD300A 2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/1165 15/18722 0.238803484673687 0.461095273296665 ZFP36/PABPC1 2 GO:0060253 negative regulation of glial cell proliferation 2/1165 15/18722 0.238803484673687 0.461095273296665 PTN/TSPO 2 GO:0060413 atrial septum morphogenesis 2/1165 15/18722 0.238803484673687 0.461095273296665 ISL1/SOX4 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/1165 15/18722 0.238803484673687 0.461095273296665 DAB2/PHB 2 GO:0070131 positive regulation of mitochondrial translation 2/1165 15/18722 0.238803484673687 0.461095273296665 C1QBP/UQCC2 2 GO:0070831 basement membrane assembly 2/1165 15/18722 0.238803484673687 0.461095273296665 LAMB1/DAG1 2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC9A1/CIB1 2 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 2/1165 15/18722 0.238803484673687 0.461095273296665 NPM1/RAN 2 GO:0071474 cellular hyperosmotic response 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC2A1/AKR1B1 2 GO:0071871 response to epinephrine 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC9A1/ATP2B4 2 GO:0072044 collecting duct development 2/1165 15/18722 0.238803484673687 0.461095273296665 DLG5/AKR1B1 2 GO:0106058 positive regulation of calcineurin-mediated signaling 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC9A1/CIB1 2 GO:0110156 methylguanosine-cap decapping 2/1165 15/18722 0.238803484673687 0.461095273296665 ZFP36/PNRC2 2 GO:1900029 positive regulation of ruffle assembly 2/1165 15/18722 0.238803484673687 0.461095273296665 EPS8/HRAS 2 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/1165 15/18722 0.238803484673687 0.461095273296665 HSPA5/UFL1 2 GO:1901741 positive regulation of myoblast fusion 2/1165 15/18722 0.238803484673687 0.461095273296665 GDF15/CD53 2 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 2/1165 15/18722 0.238803484673687 0.461095273296665 LIN28B/TGFB1 2 GO:1904424 regulation of GTP binding 2/1165 15/18722 0.238803484673687 0.461095273296665 MET/STMN1 2 GO:1905168 positive regulation of double-strand break repair via homologous recombination 2/1165 15/18722 0.238803484673687 0.461095273296665 PARP1/FUS 2 GO:1990822 basic amino acid transmembrane transport 2/1165 15/18722 0.238803484673687 0.461095273296665 SLC38A9/SLC7A7 2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 2/1165 15/18722 0.238803484673687 0.461095273296665 GPC3/DAB2 2 GO:2000345 regulation of hepatocyte proliferation 2/1165 15/18722 0.238803484673687 0.461095273296665 PTN/SULF2 2 GO:2001138 regulation of phospholipid transport 2/1165 15/18722 0.238803484673687 0.461095273296665 DBI/APOE 2 GO:0000724 double-strand break repair via homologous recombination 11/1165 138/18722 0.240517788052675 0.464245647984754 PARP1/MCM3/PSMD14/MCM6/MAGEF1/MCM7/FUS/NUCKS1/RPA3/MORF4L1/RAD21 11 GO:0030520 intracellular estrogen receptor signaling pathway 5/1165 54/18722 0.244336130481054 0.471453661186028 ISL1/PARP1/YAP1/SKP2/UFL1 5 GO:0006939 smooth muscle contraction 9/1165 110/18722 0.245615401399658 0.473433807711635 SOD1/TBX3/ATP2B1/DLG1/RHOA/PIK3C2A/ATP2B4/SLC8A1/SULF2 9 GO:0048259 regulation of receptor-mediated endocytosis 9/1165 110/18722 0.245615401399658 0.473433807711635 B2M/AAK1/DAB2/LRPAP1/VEGFA/APOC1/WASL/CD2AP/SYK 9 GO:1905954 positive regulation of lipid localization 9/1165 110/18722 0.245615401399658 0.473433807711635 PTGES/HILPDA/DBI/NFKBIA/APOE/PLIN2/TREM2/RETN/LRP1 9 GO:0030510 regulation of BMP signaling pathway 8/1165 96/18722 0.247379633648789 0.475712895323945 FBN1/LRP2/CRIM1/FSTL1/GPC3/HTRA1/SKIL/SORL1 8 GO:0031640 killing of cells of other organism 6/1165 68/18722 0.247560550016256 0.475712895323945 LYZ/GAPDH/TREM1/S100A12/ROMO1/SYK 6 GO:0032922 circadian regulation of gene expression 6/1165 68/18722 0.247560550016256 0.475712895323945 MAGED1/LGR4/ID1/GFPT1/BHLHE41/HDAC2 6 GO:0034394 protein localization to cell surface 6/1165 68/18722 0.247560550016256 0.475712895323945 JAM3/TYROBP/HSP90AB1/FCN1/FLNA/RAB11A 6 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 6/1165 68/18722 0.247560550016256 0.475712895323945 ISL1/IL6ST/HDAC2/PARP9/JAK2/LYN 6 GO:0042698 ovulation cycle 6/1165 68/18722 0.247560550016256 0.475712895323945 EGFR/ADAMTS1/SERPINF1/PTN/HSPA5/RETN 6 GO:0042987 amyloid precursor protein catabolic process 6/1165 68/18722 0.247560550016256 0.475712895323945 DHCR24/EFNA1/APOE/CLN3/SORL1/LYN 6 GO:0051148 negative regulation of muscle cell differentiation 6/1165 68/18722 0.247560550016256 0.475712895323945 PDCD4/DNMT1/FOXO4/BHLHE41/IGF2/YBX1 6 GO:0051926 negative regulation of calcium ion transport 6/1165 68/18722 0.247560550016256 0.475712895323945 C4orf3/GSTO1/LILRB2/LILRB1/YWHAE/VDAC1 6 GO:0045598 regulation of fat cell differentiation 11/1165 139/18722 0.247716100247857 0.475848894829303 BMP7/LRP5/ADIRF/GATA3/FERMT2/YAP1/KLF5/ZFP36/CEBPB/TGFB1/ZFP36L1 11 GO:0002312 B cell activation involved in immune response 7/1165 82/18722 0.248219000032299 0.476488798625614 HSPD1/TFRC/PTPRC/SPI1/TGFB1/DOCK10/GAPT 7 GO:1905897 regulation of response to endoplasmic reticulum stress 7/1165 82/18722 0.248219000032299 0.476488798625614 PMAIP1/HSPA5/USP14/PARK7/UFL1/ERP29/MANF 7 GO:0046777 protein autophosphorylation 17/1165 227/18722 0.248558843822006 0.476978047990742 EGFR/EPHB4/AAK1/FLT1/IGF1R/YES1/VEGFA/PTPRC/EIF2AK1/EIF2AK4/STK26/RAD50/HCK/FGR/SYK/JAK2/LYN 17 GO:0010907 positive regulation of glucose metabolic process 4/1165 41/18722 0.250066884295179 0.479018616555114 SORBS1/DDB1/PMAIP1/IGF2 4 GO:0051693 actin filament capping 4/1165 41/18722 0.250066884295179 0.479018616555114 SCIN/EPS8/TRIOBP/ADD3 4 GO:0055007 cardiac muscle cell differentiation 10/1165 125/18722 0.250912592260538 0.479018616555114 ISL1/OBSL1/TBX3/SLC9A1/ITGB1/VEGFA/TGFB1/CALR/SLC8A1/CCNB1 10 GO:2000027 regulation of animal organ morphogenesis 10/1165 125/18722 0.250912592260538 0.479018616555114 MAGED1/BMP7/LGR4/TACSTD2/ZNRF3/GATA3/GPC3/DAB2/RHOA/VEGFA 10 GO:0006417 regulation of translation 33/1165 468/18722 0.251412828996323 0.479018616555114 IGF2BP3/APP/GAPDH/NPM1/ZFP36/PRKDC/RHOA/SOX4/C1QBP/VIM/EIF2AK1/DHX36/EIF2AK4/DDX1/EIF1/SERP1/PA2G4/RPS14/LRPPRC/RPL5/PKM/UQCC2/EIF5/PABPC1/CALR/YBX1/TYMS/EIF5B/NCL/ZFP36L1/RBM3/RPS3/CIRBP 33 GO:0010506 regulation of autophagy 23/1165 317/18722 0.251515893504165 0.479018616555114 MET/ATP6V1B1/ATP6V1C2/GAPDH/BNIP3L/SESN1/SCOC/SLC25A5/CISD1/PIK3C2A/PYCARD/TREM2/PARK7/TRIM22/BAD/UFL1/SNX6/IFI16/CLN3/TSPO/BNIP3/VDAC1/ATP6V1E1 23 GO:0006516 glycoprotein catabolic process 3/1165 28/18722 0.251585049279258 0.479018616555114 CTSL/GPC1/CST3 3 GO:0006829 zinc ion transport 3/1165 28/18722 0.251585049279258 0.479018616555114 SLC39A10/SLC39A1/SLC39A7 3 GO:0007064 mitotic sister chromatid cohesion 3/1165 28/18722 0.251585049279258 0.479018616555114 NAA10/RAD21/SMC3 3 GO:0009312 oligosaccharide biosynthetic process 3/1165 28/18722 0.251585049279258 0.479018616555114 FBP1/FUT8/ST3GAL4 3 GO:0010464 regulation of mesenchymal cell proliferation 3/1165 28/18722 0.251585049279258 0.479018616555114 LRP5/PTN/STAT1 3 GO:0015740 C4-dicarboxylate transport 3/1165 28/18722 0.251585049279258 0.479018616555114 SLC13A3/SLC1A3/SLC25A13 3 GO:0019098 reproductive behavior 3/1165 28/18722 0.251585049279258 0.479018616555114 APP/HDAC2/MBD2 3 GO:0031440 regulation of mRNA 3'-end processing 3/1165 28/18722 0.251585049279258 0.479018616555114 DHX36/ZFP36L1/CCNB1 3 GO:0034123 positive regulation of toll-like receptor signaling pathway 3/1165 28/18722 0.251585049279258 0.479018616555114 CYBA/RSAD2/TLR2 3 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 3/1165 28/18722 0.251585049279258 0.479018616555114 EGFR/VPS25/SNX6 3 GO:0060325 face morphogenesis 3/1165 28/18722 0.251585049279258 0.479018616555114 ARID5B/DLX5/RRAS 3 GO:0060765 regulation of androgen receptor signaling pathway 3/1165 28/18722 0.251585049279258 0.479018616555114 DAB2/PARK7/PHB 3 GO:0062125 regulation of mitochondrial gene expression 3/1165 28/18722 0.251585049279258 0.479018616555114 C1QBP/LRPPRC/UQCC2 3 GO:0080111 DNA demethylation 3/1165 28/18722 0.251585049279258 0.479018616555114 GATA3/APOBEC3A/APEX1 3 GO:0090344 negative regulation of cell aging 3/1165 28/18722 0.251585049279258 0.479018616555114 CDK6/PRKDC/YBX1 3 GO:0099623 regulation of cardiac muscle cell membrane repolarization 3/1165 28/18722 0.251585049279258 0.479018616555114 GJA5/FLNA/AKAP9 3 GO:1902624 positive regulation of neutrophil migration 3/1165 28/18722 0.251585049279258 0.479018616555114 C1QBP/CD74/ADAM8 3 GO:0000725 recombinational repair 11/1165 140/18722 0.254990755407685 0.48481332497078 PARP1/MCM3/PSMD14/MCM6/MAGEF1/MCM7/FUS/NUCKS1/RPA3/MORF4L1/RAD21 11 GO:0015748 organophosphate ester transport 11/1165 140/18722 0.254990755407685 0.48481332497078 GJA1/SLC19A1/KCNN4/DBI/APOE/ATP10D/SLC25A5/PLSCR1/APOC1/SLC25A36/SLC29A1 11 GO:0046165 alcohol biosynthetic process 11/1165 140/18722 0.254990755407685 0.48481332497078 ISYNA1/SOD1/DHCR24/FDFT1/APOE/AKR1B1/FDPS/PGP/PMVK/PARK7/GCH1 11 GO:0050768 negative regulation of neurogenesis 11/1165 140/18722 0.254990755407685 0.48481332497078 SEMA6A/SEMA6D/BMP7/B2M/NRP1/PTN/ID1/TREM2/PCM1/TSPO/SORL1 11 GO:0016358 dendrite development 18/1165 243/18722 0.255060350728437 0.48481332497078 BMP7/DLG5/APP/OBSL1/EFNA1/NRP1/APOE/ITGB1/PTN/ID1/RHOA/LST1/DHX36/HDAC2/ARF4/WASL/DOCK10/ABI3 18 GO:1990868 response to chemokine 8/1165 97/18722 0.256199559062054 0.486537006728041 CXCR4/DUSP1/RHOA/CCL3L3/CIB1/TREM2/CXCL10/CCL4 8 GO:1990869 cellular response to chemokine 8/1165 97/18722 0.256199559062054 0.486537006728041 CXCR4/DUSP1/RHOA/CCL3L3/CIB1/TREM2/CXCL10/CCL4 8 GO:0031113 regulation of microtubule polymerization 5/1165 55/18722 0.256227221073952 0.486537006728041 MET/CLIP1/AKAP9/STMN1/RPS3 5 GO:0007519 skeletal muscle tissue development 12/1165 155/18722 0.258145829892756 0.490014387280365 NR2F2/GPC1/KLF5/VAMP5/GPX1/FOS/RHOA/TGFB1/GPCPD1/UQCC2/IGF2/NR4A1 12 GO:0071695 anatomical structure maturation 17/1165 229/18722 0.259922714832312 0.490043932401141 DAG1/FERMT1/TFCP2L1/APP/GATA3/EPAS1/KLF2/SNX10/C1QA/AKR1B1/RHOA/VEGFA/FAM210B/DLD/TYMS/DEFB1/CCNB1 17 GO:0010633 negative regulation of epithelial cell migration 9/1165 112/18722 0.262073272092617 0.490043932401141 NR2F2/TACSTD2/SERPINF1/MARVELD3/APOE/RHOA/KLF4/ATP2B4/TGFB1 9 GO:0035601 protein deacylation 9/1165 112/18722 0.262073272092617 0.490043932401141 BEX4/NOTUM/TBL1X/VEGFA/MORF4L2/FLNA/HDAC2/MORF4L1/PHB 9 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/1165 16/18722 0.262439348084417 0.490043932401141 ENPEP/MME 2 GO:0002693 positive regulation of cellular extravasation 2/1165 16/18722 0.262439348084417 0.490043932401141 JAM3/ADAM8 2 GO:0006206 pyrimidine nucleobase metabolic process 2/1165 16/18722 0.262439348084417 0.490043932401141 TYMP/TYMS 2 GO:0006349 regulation of gene expression by genetic imprinting 2/1165 16/18722 0.262439348084417 0.490043932401141 DNMT3A/IGF2 2 GO:0006544 glycine metabolic process 2/1165 16/18722 0.262439348084417 0.490043932401141 GLDC/GCSH 2 GO:0006828 manganese ion transport 2/1165 16/18722 0.262439348084417 0.490043932401141 SLC11A1/TMEM165 2 GO:0006857 oligopeptide transport 2/1165 16/18722 0.262439348084417 0.490043932401141 GJA1/SLC13A3 2 GO:0009074 aromatic amino acid family catabolic process 2/1165 16/18722 0.262439348084417 0.490043932401141 IL4I1/KYNU 2 GO:0010225 response to UV-C 2/1165 16/18722 0.262439348084417 0.490043932401141 MDM2/HMGN1 2 GO:0019081 viral translation 2/1165 16/18722 0.262439348084417 0.490043932401141 EIF2AK4/EIF3A 2 GO:0021535 cell migration in hindbrain 2/1165 16/18722 0.262439348084417 0.490043932401141 ITGB1/FLNA 2 GO:0030540 female genitalia development 2/1165 16/18722 0.262439348084417 0.490043932401141 LRP2/TBX3 2 GO:0030575 nuclear body organization 2/1165 16/18722 0.262439348084417 0.490043932401141 SERBP1/SF1 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/1165 16/18722 0.262439348084417 0.490043932401141 BMP7/CD44 2 GO:0034138 toll-like receptor 3 signaling pathway 2/1165 16/18722 0.262439348084417 0.490043932401141 COLEC12/OAS1 2 GO:0034375 high-density lipoprotein particle remodeling 2/1165 16/18722 0.262439348084417 0.490043932401141 APOE/APOC1 2 GO:0034393 positive regulation of smooth muscle cell apoptotic process 2/1165 16/18722 0.262439348084417 0.490043932401141 SOD2/PDCD4 2 GO:0035067 negative regulation of histone acetylation 2/1165 16/18722 0.262439348084417 0.490043932401141 SPI1/SET 2 GO:0035970 peptidyl-threonine dephosphorylation 2/1165 16/18722 0.262439348084417 0.490043932401141 DUSP5/DUSP1 2 GO:0045721 negative regulation of gluconeogenesis 2/1165 16/18722 0.262439348084417 0.490043932401141 PGP/FAM3C 2 GO:0046037 GMP metabolic process 2/1165 16/18722 0.262439348084417 0.490043932401141 DLG1/IMPDH2 2 GO:0046135 pyrimidine nucleoside catabolic process 2/1165 16/18722 0.262439348084417 0.490043932401141 APOBEC3A/UPP1 2 GO:0048385 regulation of retinoic acid receptor signaling pathway 2/1165 16/18722 0.262439348084417 0.490043932401141 KLF2/CALR 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/1165 16/18722 0.262439348084417 0.490043932401141 KCNN4/RPS3 2 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 2/1165 16/18722 0.262439348084417 0.490043932401141 CXCR4/NR2F6 2 GO:0051238 sequestering of metal ion 2/1165 16/18722 0.262439348084417 0.490043932401141 FTH1/S100A8 2 GO:0060330 regulation of response to interferon-gamma 2/1165 16/18722 0.262439348084417 0.490043932401141 HSP90AB1/PARP9 2 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/1165 16/18722 0.262439348084417 0.490043932401141 HSP90AB1/PARP9 2 GO:0061548 ganglion development 2/1165 16/18722 0.262439348084417 0.490043932401141 NRP2/NRP1 2 GO:0061684 chaperone-mediated autophagy 2/1165 16/18722 0.262439348084417 0.490043932401141 HSP90AA1/HSPA8 2 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 2/1165 16/18722 0.262439348084417 0.490043932401141 OAS1/SYK 2 GO:0090231 regulation of spindle checkpoint 2/1165 16/18722 0.262439348084417 0.490043932401141 DUSP1/CCNB1 2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 2/1165 16/18722 0.262439348084417 0.490043932401141 DUSP1/CCNB1 2 GO:0097428 protein maturation by iron-sulfur cluster transfer 2/1165 16/18722 0.262439348084417 0.490043932401141 MAGEF1/GLRX5 2 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/1165 16/18722 0.262439348084417 0.490043932401141 NSG1/RAB11A 2 GO:0099010 modification of postsynaptic structure 2/1165 16/18722 0.262439348084417 0.490043932401141 MYH10/RHOA 2 GO:1901201 regulation of extracellular matrix assembly 2/1165 16/18722 0.262439348084417 0.490043932401141 DAG1/TGFB1 2 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/1165 16/18722 0.262439348084417 0.490043932401141 CD44/CD74 2 GO:1902931 negative regulation of alcohol biosynthetic process 2/1165 16/18722 0.262439348084417 0.490043932401141 SOD1/APOE 2 GO:1903504 regulation of mitotic spindle checkpoint 2/1165 16/18722 0.262439348084417 0.490043932401141 DUSP1/CCNB1 2 GO:1904683 regulation of metalloendopeptidase activity 2/1165 16/18722 0.262439348084417 0.490043932401141 TIMP3/SORL1 2 GO:1905153 regulation of membrane invagination 2/1165 16/18722 0.262439348084417 0.490043932401141 TREM2/CD300A 2 GO:1905874 regulation of postsynaptic density organization 2/1165 16/18722 0.262439348084417 0.490043932401141 LILRB2/ABI3 2 GO:2000765 regulation of cytoplasmic translation 2/1165 16/18722 0.262439348084417 0.490043932401141 DHX36/PKM 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/1165 16/18722 0.262439348084417 0.490043932401141 PRKDC/PARP9 2 GO:2001224 positive regulation of neuron migration 2/1165 16/18722 0.262439348084417 0.490043932401141 SEMA6A/FLNA 2 GO:0006040 amino sugar metabolic process 4/1165 42/18722 0.263989633526977 0.491467267989028 EXTL2/GFPT1/MGAT1/NPL 4 GO:0007212 dopamine receptor signaling pathway 4/1165 42/18722 0.263989633526977 0.491467267989028 NSG1/GNAS/GNA11/FLNA 4 GO:0014003 oligodendrocyte development 4/1165 42/18722 0.263989633526977 0.491467267989028 GSTP1/CD9/TLR2/LYN 4 GO:0021795 cerebral cortex cell migration 4/1165 42/18722 0.263989633526977 0.491467267989028 ADGRG1/LAMB1/GLI3/RHOA 4 GO:0030574 collagen catabolic process 4/1165 42/18722 0.263989633526977 0.491467267989028 CTSL/CTSS/ITGB1/CST3 4 GO:0032965 regulation of collagen biosynthetic process 4/1165 42/18722 0.263989633526977 0.491467267989028 VIM/TGFB1/HDAC2/SUCO 4 GO:0045214 sarcomere organization 4/1165 42/18722 0.263989633526977 0.491467267989028 KRT8/CSRP2/ITGB1/KRT19 4 GO:0046688 response to copper ion 4/1165 42/18722 0.263989633526977 0.491467267989028 SOD3/APP/SOD1/PARK7 4 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 4/1165 42/18722 0.263989633526977 0.491467267989028 DUSP1/CENPF/RAD21/CCNB1 4 GO:0006814 sodium ion transport 18/1165 245/18722 0.26617040753459 0.495362897046305 SLC6A4/SLC38A1/SLC13A4/FXYD3/ATP6V1B1/ANK3/PRSS8/SLC13A3/SLC9A1/SLC5A3/MAGED2/DLG1/FXYD5/SLC5A6/ATP2B4/GLRX/SLC8A1/UTRN 18 GO:0035270 endocrine system development 10/1165 127/18722 0.26645944820968 0.495736454358945 CDH1/PBX1/ISL1/GATA3/CDK6/ARID5B/SOX4/BAD/TSPO/CGA 10 GO:0048469 cell maturation 13/1165 171/18722 0.267298898252452 0.496184450836176 TFCP2L1/APP/GATA3/EPAS1/KLF2/C1QA/AKR1B1/VEGFA/FAM210B/DLD/TYMS/DEFB1/CCNB1 13 GO:0032370 positive regulation of lipid transport 7/1165 84/18722 0.26751879356399 0.496184450836176 PTGES/DBI/NFKBIA/APOE/TREM2/RETN/LRP1 7 GO:0045445 myoblast differentiation 7/1165 84/18722 0.26751879356399 0.496184450836176 ISL1/MBNL3/EPAS1/TBX3/TGFB1/CXCL10/ZFP36L1 7 GO:1900542 regulation of purine nucleotide metabolic process 7/1165 84/18722 0.26751879356399 0.496184450836176 APP/TMSB4X/PARP1/FBP1/VCP/TREM2/ENO1 7 GO:0015800 acidic amino acid transport 5/1165 56/18722 0.268254057533324 0.496184450836176 GJA1/ITGB1/ARL6IP5/SLC1A3/SLC25A13 5 GO:0022029 telencephalon cell migration 5/1165 56/18722 0.268254057533324 0.496184450836176 ADGRG1/LAMB1/CXCR4/GLI3/RHOA 5 GO:0001773 myeloid dendritic cell activation 3/1165 29/18722 0.26873342785355 0.496184450836176 ITGB8/SPI1/PYCARD 3 GO:0002360 T cell lineage commitment 3/1165 29/18722 0.26873342785355 0.496184450836176 CTSL/PRKDC/RHOA 3 GO:0006734 NADH metabolic process 3/1165 29/18722 0.26873342785355 0.496184450836176 VCP/MDH1/ENO1 3 GO:0009218 pyrimidine ribonucleotide metabolic process 3/1165 29/18722 0.26873342785355 0.496184450836176 UPP1/AK3/NME1 3 GO:0019359 nicotinamide nucleotide biosynthetic process 3/1165 29/18722 0.26873342785355 0.496184450836176 QPRT/KYNU/PARP9 3 GO:0019363 pyridine nucleotide biosynthetic process 3/1165 29/18722 0.26873342785355 0.496184450836176 QPRT/KYNU/PARP9 3 GO:0022011 myelination in peripheral nervous system 3/1165 29/18722 0.26873342785355 0.496184450836176 ITGB4/DAG1/SOD1 3 GO:0032292 peripheral nervous system axon ensheathment 3/1165 29/18722 0.26873342785355 0.496184450836176 ITGB4/DAG1/SOD1 3 GO:0035066 positive regulation of histone acetylation 3/1165 29/18722 0.26873342785355 0.496184450836176 ISL1/GATA3/BRD7 3 GO:0048665 neuron fate specification 3/1165 29/18722 0.26873342785355 0.496184450836176 ISL1/ESRP1/GLI3 3 GO:0051654 establishment of mitochondrion localization 3/1165 29/18722 0.26873342785355 0.496184450836176 UBB/ARMCX3/LRPPRC 3 GO:0051873 killing by host of symbiont cells 3/1165 29/18722 0.26873342785355 0.496184450836176 GAPDH/TREM1/ROMO1 3 GO:0051883 killing of cells in other organism involved in symbiotic interaction 3/1165 29/18722 0.26873342785355 0.496184450836176 GAPDH/TREM1/ROMO1 3 GO:0060969 negative regulation of gene silencing 3/1165 29/18722 0.26873342785355 0.496184450836176 LIN28B/KCNQ1OT1/TGFB1 3 GO:0071549 cellular response to dexamethasone stimulus 3/1165 29/18722 0.26873342785355 0.496184450836176 EGFR/SERPINF1/ASS1 3 GO:0095500 acetylcholine receptor signaling pathway 3/1165 29/18722 0.26873342785355 0.496184450836176 GNA11/RGS10/GNAI2 3 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/1165 29/18722 0.26873342785355 0.496184450836176 CD44/CD74/USP47 3 GO:0042770 signal transduction in response to DNA damage 13/1165 172/18722 0.274070698972327 0.505872684423437 CD44/NPM1/PMAIP1/FOXO4/PRKDC/SOX4/GRB2/EIF2AK4/CCND1/CD74/SMYD2/MDM2/BABAM1 13 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 10/1165 128/18722 0.27434527877895 0.506213034117768 APP/NCF1/VEGFA/SPI1/PYCARD/ARL6IP5/GADD45G/HRAS/PRMT1/LYN 10 GO:0009913 epidermal cell differentiation 15/1165 202/18722 0.276353039756198 0.50975011901135 DSP/EXPH5/ESRP1/SOD1/YAP1/MYO7A/ZFP36/IRF6/KLF4/TXNIP/OPN3/NCOA3/TRIOBP/HDAC2/ZFP36L1 15 GO:0006865 amino acid transport 11/1165 143/18722 0.277239662200553 0.510701215966909 SLC38A1/GJA1/SLC38A9/ITGB1/SLC11A1/ARL6IP5/SLC1A3/SFXN4/SLC25A13/CLN3/SLC7A7 11 GO:0032092 positive regulation of protein binding 7/1165 85/18722 0.277318397990624 0.510701215966909 B2M/APP/HSP90AB1/NRP1/APOE/RAN/LRP1 7 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 7/1165 85/18722 0.277318397990624 0.510701215966909 ISL1/IL6ST/HDAC2/SOCS3/PARP9/JAK2/LYN 7 GO:0006284 base-excision repair 4/1165 43/18722 0.278051472651857 0.510701215966909 RPA3/USP47/APEX1/RPS3 4 GO:0033046 negative regulation of sister chromatid segregation 4/1165 43/18722 0.278051472651857 0.510701215966909 DUSP1/CENPF/RAD21/CCNB1 4 GO:0033048 negative regulation of mitotic sister chromatid segregation 4/1165 43/18722 0.278051472651857 0.510701215966909 DUSP1/CENPF/RAD21/CCNB1 4 GO:0033173 calcineurin-NFAT signaling cascade 4/1165 43/18722 0.278051472651857 0.510701215966909 SLC9A1/ATP2B4/CIB1/NFAT5 4 GO:0045776 negative regulation of blood pressure 4/1165 43/18722 0.278051472651857 0.510701215966909 GJA5/ADRB1/SOD2/GCH1 4 GO:0120178 steroid hormone biosynthetic process 4/1165 43/18722 0.278051472651857 0.510701215966909 HSD17B1/AKR1B1/HSD17B11/TSPO 4 GO:1901381 positive regulation of potassium ion transmembrane transport 4/1165 43/18722 0.278051472651857 0.510701215966909 KCNN4/FLNA/AKAP9/TREM2 4 GO:1903793 positive regulation of anion transport 4/1165 43/18722 0.278051472651857 0.510701215966909 TCAF1/PTGES/ITGB1/CEBPB 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/1165 43/18722 0.278051472651857 0.510701215966909 SOD2/PDCD4/RHOA/GSTP1 4 GO:2000816 negative regulation of mitotic sister chromatid separation 4/1165 43/18722 0.278051472651857 0.510701215966909 DUSP1/CENPF/RAD21/CCNB1 4 GO:0019751 polyol metabolic process 9/1165 114/18722 0.278862915738353 0.511689292592146 ISYNA1/PLPP3/SLC5A3/NUDT4/AKR1B1/TPI1/PGP/GCH1/GK 9 GO:0051261 protein depolymerization 9/1165 114/18722 0.278862915738353 0.511689292592146 SCIN/DSTN/LIMA1/EPS8/CIB1/TRIOBP/STMN1/ADD3/HSPA8 9 GO:1901800 positive regulation of proteasomal protein catabolic process 9/1165 114/18722 0.278862915738353 0.511689292592146 VCP/DAB2/BAG2/PSMC1/PSMC3/PSMC6/MDM2/TREM2/PSMC4 9 GO:0018393 internal peptidyl-lysine acetylation 12/1165 158/18722 0.279365131999543 0.512443296050143 ISL1/GATA3/MORF4L2/SPI1/USP22/RUVBL1/BRD7/NCOA3/PARK7/MORF4L1/SET/PHF20 12 GO:0000281 mitotic cytokinesis 6/1165 71/18722 0.27965010699 0.512630976660637 MYH10/ANK3/RASA1/RHOA/STMN1/SON 6 GO:0050795 regulation of behavior 6/1165 71/18722 0.27965010699 0.512630976660637 ADRB1/GJA1/APOE/EIF2AK4/RETN/HDAC2 6 GO:0010883 regulation of lipid storage 5/1165 57/18722 0.280401133610802 0.513504588240598 MEST/HILPDA/NFKBIA/PLIN2/TREM2 5 GO:0016447 somatic recombination of immunoglobulin gene segments 5/1165 57/18722 0.280401133610802 0.513504588240598 HSPD1/TFRC/PRKDC/PTPRC/TGFB1 5 GO:0061756 leukocyte adhesion to vascular endothelial cell 5/1165 57/18722 0.280401133610802 0.513504588240598 ITGB1/RHOA/KLF4/ST3GAL4/NFAT5 5 GO:0033135 regulation of peptidyl-serine phosphorylation 11/1165 144/18722 0.284786322768384 0.516662322497017 EGFR/APP/CD44/TFRC/HSP90AB1/HSP90AA1/VEGFA/ATP2B4/AKAP9/TGFB1/PARK7 11 GO:0006884 cell volume homeostasis 3/1165 30/18722 0.286007112236872 0.516662322497017 KCNN4/NPM1/CLN3 3 GO:0009072 aromatic amino acid family metabolic process 3/1165 30/18722 0.286007112236872 0.516662322497017 IL4I1/PARK7/KYNU 3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/1165 30/18722 0.286007112236872 0.516662322497017 BMP7/APP/TGFB1 3 GO:0034390 smooth muscle cell apoptotic process 3/1165 30/18722 0.286007112236872 0.516662322497017 SOD2/PDCD4/DNMT1 3 GO:0034391 regulation of smooth muscle cell apoptotic process 3/1165 30/18722 0.286007112236872 0.516662322497017 SOD2/PDCD4/DNMT1 3 GO:0034508 centromere complex assembly 3/1165 30/18722 0.286007112236872 0.516662322497017 NASP/HELLS/CENPF 3 GO:0044030 regulation of DNA methylation 3/1165 30/18722 0.286007112236872 0.516662322497017 PARP1/SPI1/MBD2 3 GO:0045940 positive regulation of steroid metabolic process 3/1165 30/18722 0.286007112236872 0.516662322497017 APOE/APOC1/CGA 3 GO:0048799 animal organ maturation 3/1165 30/18722 0.286007112236872 0.516662322497017 GATA3/SNX10/RHOA 3 GO:0051491 positive regulation of filopodium assembly 3/1165 30/18722 0.286007112236872 0.516662322497017 NRP1/FNBP1L/WASL 3 GO:0061384 heart trabecula morphogenesis 3/1165 30/18722 0.286007112236872 0.516662322497017 TGFBR3/ADAMTS1/BMP7 3 GO:0140058 neuron projection arborization 3/1165 30/18722 0.286007112236872 0.516662322497017 LRP2/NRP1/PTN 3 GO:2000637 positive regulation of gene silencing by miRNA 3/1165 30/18722 0.286007112236872 0.516662322497017 EGFR/ZFP36/TGFB1 3 GO:0001829 trophectodermal cell differentiation 2/1165 17/18722 0.286083466652544 0.516662322497017 YAP1/JUNB 2 GO:0006390 mitochondrial transcription 2/1165 17/18722 0.286083466652544 0.516662322497017 TFAM/MRPL12 2 GO:0006474 N-terminal protein amino acid acetylation 2/1165 17/18722 0.286083466652544 0.516662322497017 SOX4/NAA10 2 GO:0007351 tripartite regional subdivision 2/1165 17/18722 0.286083466652544 0.516662322497017 TBX3/BASP1 2 GO:0008595 anterior/posterior axis specification, embryo 2/1165 17/18722 0.286083466652544 0.516662322497017 TBX3/BASP1 2 GO:0015867 ATP transport 2/1165 17/18722 0.286083466652544 0.516662322497017 GJA1/SLC25A5 2 GO:0016264 gap junction assembly 2/1165 17/18722 0.286083466652544 0.516662322497017 GJA5/GJA1 2 GO:0030903 notochord development 2/1165 17/18722 0.286083466652544 0.516662322497017 EFNA1/YAP1 2 GO:0035855 megakaryocyte development 2/1165 17/18722 0.286083466652544 0.516662322497017 WASF2/PTPN6 2 GO:0036166 phenotypic switching 2/1165 17/18722 0.286083466652544 0.516662322497017 SOD2/DNMT1 2 GO:0042953 lipoprotein transport 2/1165 17/18722 0.286083466652544 0.516662322497017 VMP1/LRP1 2 GO:0043649 dicarboxylic acid catabolic process 2/1165 17/18722 0.286083466652544 0.516662322497017 QPRT/GLUL 2 GO:0044539 long-chain fatty acid import into cell 2/1165 17/18722 0.286083466652544 0.516662322497017 SLC27A2/SLC2A1 2 GO:0045198 establishment of epithelial cell apical/basal polarity 2/1165 17/18722 0.286083466652544 0.516662322497017 RHOA/MSN 2 GO:0046827 positive regulation of protein export from nucleus 2/1165 17/18722 0.286083466652544 0.516662322497017 MDM2/YWHAE 2 GO:0060263 regulation of respiratory burst 2/1165 17/18722 0.286083466652544 0.516662322497017 NCF1/GRN 2 GO:0060644 mammary gland epithelial cell differentiation 2/1165 17/18722 0.286083466652544 0.516662322497017 IRF6/CEBPB 2 GO:0061298 retina vasculature development in camera-type eye 2/1165 17/18722 0.286083466652544 0.516662322497017 LRP5/NRP1 2 GO:0070293 renal absorption 2/1165 17/18722 0.286083466652544 0.516662322497017 CLDN4/MAGED2 2 GO:0070875 positive regulation of glycogen metabolic process 2/1165 17/18722 0.286083466652544 0.516662322497017 SORBS1/IGF2 2 GO:0090083 regulation of inclusion body assembly 2/1165 17/18722 0.286083466652544 0.516662322497017 PSMC6/SORL1 2 GO:0090136 epithelial cell-cell adhesion 2/1165 17/18722 0.286083466652544 0.516662322497017 DSP/ITGB5 2 GO:0090399 replicative senescence 2/1165 17/18722 0.286083466652544 0.516662322497017 MME/ROMO1 2 GO:0140354 lipid import into cell 2/1165 17/18722 0.286083466652544 0.516662322497017 SLC27A2/SLC2A1 2 GO:1902358 sulfate transmembrane transport 2/1165 17/18722 0.286083466652544 0.516662322497017 SLC26A2/SLC13A4 2 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 2/1165 17/18722 0.286083466652544 0.516662322497017 TGFB1/LILRB4 2 GO:1903358 regulation of Golgi organization 2/1165 17/18722 0.286083466652544 0.516662322497017 PDE4DIP/AKAP9 2 GO:1903540 establishment of protein localization to postsynaptic membrane 2/1165 17/18722 0.286083466652544 0.516662322497017 NSG1/RAB11A 2 GO:1903830 magnesium ion transmembrane transport 2/1165 17/18722 0.286083466652544 0.516662322497017 TUSC3/MRS2 2 GO:1903169 regulation of calcium ion transmembrane transport 12/1165 159/18722 0.286557329078066 0.517351652658471 CYBA/TSPAN13/SLC9A1/C4orf3/PTPN6/GSTO1/VMP1/CXCL10/YWHAE/SLC8A1/VDAC1/LYN 12 GO:0006140 regulation of nucleotide metabolic process 7/1165 86/18722 0.287207137955099 0.518191470698158 APP/TMSB4X/PARP1/FBP1/VCP/TREM2/ENO1 7 GO:0015908 fatty acid transport 7/1165 86/18722 0.287207137955099 0.518191470698158 SLC27A2/SLC2A1/PTGES/APOE/PLIN2/FIS1/SYK 7 GO:0046883 regulation of hormone secretion 18/1165 249/18722 0.288905013977978 0.521087353296398 EGFR/DPP4/LRP5/GJA1/ISL1/SYT7/MPC2/HLA-DRB1/HMGN3/SOX4/SERP1/UQCC2/RETN/BAD/GLUL/LRP1/JAK2/ENSA 18 GO:1901888 regulation of cell junction assembly 15/1165 204/18722 0.289020237623289 0.521127720455998 GJA1/DLG5/APP/TJP1/FERMT2/S100A10/NRP1/SLC9A1/RHOA/VEGFA/LIMS1/PTPRA/TLR2/ABI3/LRP1 15 GO:0060560 developmental growth involved in morphogenesis 17/1165 234/18722 0.289141981107649 0.521179813730646 SEMA6A/SEMA6D/CXCR4/APP/NRP2/PRKCZ/HSP90AB1/YAP1/NRP1/APOE/HSP90AA1/ITGB1/GOLGA4/VEGFA/EIF2AK4/RAB11A/LRP1 17 GO:0000271 polysaccharide biosynthetic process 6/1165 72/18722 0.290553552899797 0.523052306743605 SORBS1/AGL/CLTC/TGFB1/IGF2/UGP2 6 GO:0001707 mesoderm formation 6/1165 72/18722 0.290553552899797 0.523052306743605 ITGB4/BMP7/WLS/GJA1/ITGB1/KLF4 6 GO:1901880 negative regulation of protein depolymerization 6/1165 72/18722 0.290553552899797 0.523052306743605 SCIN/LIMA1/EPS8/CIB1/TRIOBP/ADD3 6 GO:1905818 regulation of chromosome separation 6/1165 72/18722 0.290553552899797 0.523052306743605 DUSP1/PLSCR1/ANAPC11/CENPF/RAD21/CCNB1 6 GO:0005978 glycogen biosynthetic process 4/1165 44/18722 0.292228379612823 0.524385516229788 SORBS1/AGL/IGF2/UGP2 4 GO:0009250 glucan biosynthetic process 4/1165 44/18722 0.292228379612823 0.524385516229788 SORBS1/AGL/IGF2/UGP2 4 GO:0021517 ventral spinal cord development 4/1165 44/18722 0.292228379612823 0.524385516229788 ISL1/LMO4/GLI3/SOX4 4 GO:0030521 androgen receptor signaling pathway 4/1165 44/18722 0.292228379612823 0.524385516229788 DAB2/RHOA/PARK7/PHB 4 GO:0045124 regulation of bone resorption 4/1165 44/18722 0.292228379612823 0.524385516229788 EGFR/TFRC/SYK/ADAM8 4 GO:0048806 genitalia development 4/1165 44/18722 0.292228379612823 0.524385516229788 LRP2/LGR4/DHCR24/TBX3 4 GO:0050999 regulation of nitric-oxide synthase activity 4/1165 44/18722 0.292228379612823 0.524385516229788 EGFR/APOE/ATP2B4/GCH1 4 GO:0051150 regulation of smooth muscle cell differentiation 4/1165 44/18722 0.292228379612823 0.524385516229788 SOD2/PDCD4/DNMT1/FOXO4 4 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 4/1165 44/18722 0.292228379612823 0.524385516229788 CYBA/RSAD2/OASL/TLR2 4 GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/1165 44/18722 0.292228379612823 0.524385516229788 HSPA5/USP14/PARK7/UFL1 4 GO:0006476 protein deacetylation 8/1165 101/18722 0.292372344655206 0.524476181064132 BEX4/TBL1X/VEGFA/MORF4L2/FLNA/HDAC2/MORF4L1/PHB 8 GO:2000736 regulation of stem cell differentiation 5/1165 58/18722 0.292653073528585 0.52481204527666 TACSTD2/YAP1/PTN/PRKDC/DHX36 5 GO:0035967 cellular response to topologically incorrect protein 9/1165 116/18722 0.295944645022052 0.530375891605612 HSPD1/HSPA5/VCP/CCND1/SERP1/ERO1A/UFL1/CREB3L2/HSPA8 9 GO:0098732 macromolecule deacylation 9/1165 116/18722 0.295944645022052 0.530375891605612 BEX4/NOTUM/TBL1X/VEGFA/MORF4L2/FLNA/HDAC2/MORF4L1/PHB 9 GO:0044070 regulation of anion transport 7/1165 87/18722 0.297176984053056 0.531905105704656 TCAF1/GABRE/PTGES/ITGB1/CEBPB/ARL6IP5/SYK 7 GO:0051262 protein tetramerization 7/1165 87/18722 0.297176984053056 0.531905105704656 B2M/SOD2/ALDOA/HLA-DRB1/GBP5/VASP/SSBP1 7 GO:1901606 alpha-amino acid catabolic process 7/1165 87/18722 0.297176984053056 0.531905105704656 GLDC/GCSH/CDO1/IL4I1/ATP2B4/KYNU/GLUL 7 GO:1901879 regulation of protein depolymerization 7/1165 87/18722 0.297176984053056 0.531905105704656 SCIN/DSTN/LIMA1/EPS8/CIB1/TRIOBP/ADD3 7 GO:0006302 double-strand break repair 18/1165 251/18722 0.300506773957569 0.537693504056053 PARP1/MCM3/PSMD14/MCM6/MAGEF1/VCP/PRKDC/MCM7/DDX1/FUS/CIB1/RAD50/NUCKS1/RPA3/MORF4L1/RAD21/BABAM1/PARP9 18 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 6/1165 73/18722 0.301542530062291 0.539196545612522 EGFR/NCF1/IFI6/PLAUR/VPS25/SNX6 6 GO:0051145 smooth muscle cell differentiation 6/1165 73/18722 0.301542530062291 0.539196545612522 SOD2/TBX3/PDCD4/DNMT1/FOXO4/VEGFA 6 GO:0070588 calcium ion transmembrane transport 22/1165 312/18722 0.302240138673973 0.539196545612522 TMEM37/CYBA/TSPAN13/SLC9A1/ATP2B1/PTPRC/C4orf3/AFG3L2/PMPCB/ATP2B4/PTPN6/STOML2/GSTO1/ERO1A/VMP1/CXCL10/TMEM165/YWHAE/CATSPER1/SLC8A1/VDAC1/LYN 22 GO:0002717 positive regulation of natural killer cell mediated immunity 3/1165 31/18722 0.303364099598137 0.539196545612522 CADM1/HLA-E/HLA-F 3 GO:0007190 activation of adenylate cyclase activity 3/1165 31/18722 0.303364099598137 0.539196545612522 LGR5/LGR4/ADRB1 3 GO:0030201 heparan sulfate proteoglycan metabolic process 3/1165 31/18722 0.303364099598137 0.539196545612522 EXTL2/GPC1/SULF2 3 GO:0032148 activation of protein kinase B activity 3/1165 31/18722 0.303364099598137 0.539196545612522 PRKCZ/PARK7/PPIA 3 GO:0035510 DNA dealkylation 3/1165 31/18722 0.303364099598137 0.539196545612522 GATA3/APOBEC3A/APEX1 3 GO:0042133 neurotransmitter metabolic process 3/1165 31/18722 0.303364099598137 0.539196545612522 SLC6A4/COMT/CLN3 3 GO:0043171 peptide catabolic process 3/1165 31/18722 0.303364099598137 0.539196545612522 ENPEP/CTSH/ANPEP 3 GO:0048384 retinoic acid receptor signaling pathway 3/1165 31/18722 0.303364099598137 0.539196545612522 ESRRG/KLF2/CALR 3 GO:0051569 regulation of histone H3-K4 methylation 3/1165 31/18722 0.303364099598137 0.539196545612522 GATA3/DNMT1/RTF1 3 GO:0060045 positive regulation of cardiac muscle cell proliferation 3/1165 31/18722 0.303364099598137 0.539196545612522 TGFBR3/YAP1/CCNB1 3 GO:0060148 positive regulation of posttranscriptional gene silencing 3/1165 31/18722 0.303364099598137 0.539196545612522 EGFR/ZFP36/TGFB1 3 GO:0065005 protein-lipid complex assembly 3/1165 31/18722 0.303364099598137 0.539196545612522 APOE/PRKACB/APOC1 3 GO:0070528 protein kinase C signaling 3/1165 31/18722 0.303364099598137 0.539196545612522 ADGRG1/PRKCZ/VEGFA 3 GO:0070723 response to cholesterol 3/1165 31/18722 0.303364099598137 0.539196545612522 DAG1/TGFB1/PMVK 3 GO:0071168 protein localization to chromatin 3/1165 31/18722 0.303364099598137 0.539196545612522 VCP/SPI1/RAD21 3 GO:0097106 postsynaptic density organization 3/1165 31/18722 0.303364099598137 0.539196545612522 DLG1/LILRB2/ABI3 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/1165 31/18722 0.303364099598137 0.539196545612522 CD44/CD74/MDM2 3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/1165 31/18722 0.303364099598137 0.539196545612522 GPX1/PARK7/PEA15 3 GO:0014902 myotube differentiation 9/1165 117/18722 0.304582463188389 0.540263668852164 ERVW-1/KLF5/GPX1/CD9/BHLHE41/GDF15/PLEKHO1/CD53/CXCL10 9 GO:0021885 forebrain cell migration 5/1165 59/18722 0.304994679339941 0.540263668852164 ADGRG1/LAMB1/CXCR4/GLI3/RHOA 5 GO:0032768 regulation of monooxygenase activity 5/1165 59/18722 0.304994679339941 0.540263668852164 EGFR/APOE/ATP2B4/PARK7/GCH1 5 GO:0051055 negative regulation of lipid biosynthetic process 5/1165 59/18722 0.304994679339941 0.540263668852164 SOD1/APOE/ORMDL1/APOC1/ACADVL 5 GO:0003197 endocardial cushion development 4/1165 45/18722 0.306496923910863 0.540263668852164 BMP7/ISL1/TBX3/MDM2 4 GO:0006903 vesicle targeting 4/1165 45/18722 0.306496923910863 0.540263668852164 AP1M2/TFG/TMED9/PDCD6 4 GO:0030850 prostate gland development 4/1165 45/18722 0.306496923910863 0.540263668852164 BMP7/SERPINF1/GLI3/CRIP1 4 GO:0031670 cellular response to nutrient 4/1165 45/18722 0.306496923910863 0.540263668852164 FOLR1/PTN/ATP2B1/MDM2 4 GO:0035305 negative regulation of dephosphorylation 4/1165 45/18722 0.306496923910863 0.540263668852164 LGALS3/GNAI2/YWHAE/ENSA 4 GO:0035987 endodermal cell differentiation 4/1165 45/18722 0.306496923910863 0.540263668852164 COL4A2/LAMB1/ITGB5/RTF1 4 GO:0051985 negative regulation of chromosome segregation 4/1165 45/18722 0.306496923910863 0.540263668852164 DUSP1/CENPF/RAD21/CCNB1 4 GO:0060421 positive regulation of heart growth 4/1165 45/18722 0.306496923910863 0.540263668852164 TGFBR3/YAP1/BASP1/CCNB1 4 GO:1901985 positive regulation of protein acetylation 4/1165 45/18722 0.306496923910863 0.540263668852164 ISL1/GATA3/SOX4/BRD7 4 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 4/1165 45/18722 0.306496923910863 0.540263668852164 BNIP3L/SLC25A5/NMT1/BNIP3 4 GO:1905819 negative regulation of chromosome separation 4/1165 45/18722 0.306496923910863 0.540263668852164 DUSP1/CENPF/RAD21/CCNB1 4 GO:0007260 tyrosine phosphorylation of STAT protein 7/1165 88/18722 0.307219908075685 0.540263668852164 ISL1/IL6ST/HDAC2/SOCS3/PARP9/JAK2/LYN 7 GO:0030101 natural killer cell activation 7/1165 88/18722 0.307219908075685 0.540263668852164 PBX1/TYROBP/HLA-E/PRDX1/HLA-F/PTPRC/FGR 7 GO:0050829 defense response to Gram-negative bacterium 7/1165 88/18722 0.307219908075685 0.540263668852164 LYZ/TREM1/PYCARD/SLC11A1/TREM2/ROMO1/DEFB1 7 GO:0015931 nucleobase-containing compound transport 16/1165 222/18722 0.30783908762152 0.540263668852164 GJA1/IGF2BP3/SLC19A1/SLC35B4/NPM1/ZFP36/SLC25A5/NCBP3/MX2/RAN/SLC25A36/LRPPRC/SLC29A1/YBX1/ZFP36L1/NUP214 16 GO:0021953 central nervous system neuron differentiation 12/1165 162/18722 0.30844963798085 0.540263668852164 ISL1/B2M/NRP2/LMO4/GLI3/UQCRQ/HSP90AB1/NRP1/HSP90AA1/UBB/SOX4/C12orf57 12 GO:0051302 regulation of cell division 13/1165 177/18722 0.308715287781545 0.540263668852164 ASPM/PTN/RHOA/VEGFA/EVI2B/ORC6/CIB1/TGFB1/TXNIP/NCOA3/IGF2/YBX1/RAB11A 13 GO:0051648 vesicle localization 13/1165 177/18722 0.308715287781545 0.540263668852164 PRKCZ/MYO7A/FNBP1L/AP1M2/TFG/TMED9/CCDC186/MYO1G/WASL/CLN3/RAB11A/PDCD6/MYO1F 13 GO:0003128 heart field specification 2/1165 18/18722 0.30964336766389 0.540263668852164 LRP2/ISL1 2 GO:0006103 2-oxoglutarate metabolic process 2/1165 18/18722 0.30964336766389 0.540263668852164 IDH1/DLD 2 GO:0008272 sulfate transport 2/1165 18/18722 0.30964336766389 0.540263668852164 SLC26A2/SLC13A4 2 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 2/1165 18/18722 0.30964336766389 0.540263668852164 AK3/NME1 2 GO:0015693 magnesium ion transport 2/1165 18/18722 0.30964336766389 0.540263668852164 TUSC3/MRS2 2 GO:0030728 ovulation 2/1165 18/18722 0.30964336766389 0.540263668852164 ADAMTS1/HPGD 2 GO:0030730 sequestering of triglyceride 2/1165 18/18722 0.30964336766389 0.540263668852164 PLIN2/TREM2 2 GO:0031000 response to caffeine 2/1165 18/18722 0.30964336766389 0.540263668852164 HDAC2/SLC8A1 2 GO:0031643 positive regulation of myelination 2/1165 18/18722 0.30964336766389 0.540263668852164 DAG1/TNFRSF1B 2 GO:0031649 heat generation 2/1165 18/18722 0.30964336766389 0.540263668852164 ADRB1/PTGES 2 GO:0033189 response to vitamin A 2/1165 18/18722 0.30964336766389 0.540263668852164 DNMT3A/TYMS 2 GO:0034433 steroid esterification 2/1165 18/18722 0.30964336766389 0.540263668852164 APOE/APOC1 2 GO:0034434 sterol esterification 2/1165 18/18722 0.30964336766389 0.540263668852164 APOE/APOC1 2 GO:0034435 cholesterol esterification 2/1165 18/18722 0.30964336766389 0.540263668852164 APOE/APOC1 2 GO:0043116 negative regulation of vascular permeability 2/1165 18/18722 0.30964336766389 0.540263668852164 FERMT2/VEGFA 2 GO:0044872 lipoprotein localization 2/1165 18/18722 0.30964336766389 0.540263668852164 VMP1/LRP1 2 GO:0045653 negative regulation of megakaryocyte differentiation 2/1165 18/18722 0.30964336766389 0.540263668852164 CIB1/PRMT1 2 GO:0051447 negative regulation of meiotic cell cycle 2/1165 18/18722 0.30964336766389 0.540263668852164 DUSP1/PRKACB 2 GO:0055070 copper ion homeostasis 2/1165 18/18722 0.30964336766389 0.540263668852164 APP/SCO2 2 GO:0060008 Sertoli cell differentiation 2/1165 18/18722 0.30964336766389 0.540263668852164 CTSV/FLNA 2 GO:0060749 mammary gland alveolus development 2/1165 18/18722 0.30964336766389 0.540263668852164 VEGFA/CCND1 2 GO:0060973 cell migration involved in heart development 2/1165 18/18722 0.30964336766389 0.540263668852164 BMP7/FOLR1 2 GO:0061377 mammary gland lobule development 2/1165 18/18722 0.30964336766389 0.540263668852164 VEGFA/CCND1 2 GO:0071318 cellular response to ATP 2/1165 18/18722 0.30964336766389 0.540263668852164 SOD1/HSP90B1 2 GO:0071360 cellular response to exogenous dsRNA 2/1165 18/18722 0.30964336766389 0.540263668852164 COLEC12/IFIT1 2 GO:0072079 nephron tubule formation 2/1165 18/18722 0.30964336766389 0.540263668852164 GATA3/IRX2 2 GO:0090493 catecholamine uptake 2/1165 18/18722 0.30964336766389 0.540263668852164 PARK7/ACTB 2 GO:0097094 craniofacial suture morphogenesis 2/1165 18/18722 0.30964336766389 0.540263668852164 GLI3/MSX2 2 GO:0097709 connective tissue replacement 2/1165 18/18722 0.30964336766389 0.540263668852164 TIMP1/TGFB1 2 GO:0098877 neurotransmitter receptor transport to plasma membrane 2/1165 18/18722 0.30964336766389 0.540263668852164 NSG1/RAB11A 2 GO:0110154 RNA decapping 2/1165 18/18722 0.30964336766389 0.540263668852164 ZFP36/PNRC2 2 GO:1900006 positive regulation of dendrite development 2/1165 18/18722 0.30964336766389 0.540263668852164 BMP7/PTN 2 GO:1900225 regulation of NLRP3 inflammasome complex assembly 2/1165 18/18722 0.30964336766389 0.540263668852164 GBP5/TREM2 2 GO:1900424 regulation of defense response to bacterium 2/1165 18/18722 0.30964336766389 0.540263668852164 CYBA/GRN 2 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 2/1165 18/18722 0.30964336766389 0.540263668852164 SEMA6A/ATP2B4 2 GO:1905820 positive regulation of chromosome separation 2/1165 18/18722 0.30964336766389 0.540263668852164 PLSCR1/ANAPC11 2 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 2/1165 18/18722 0.30964336766389 0.540263668852164 ISL1/TBX3 2 GO:0044262 cellular carbohydrate metabolic process 20/1165 283/18722 0.309996416240475 0.540711586189492 ISYNA1/PHLDA2/SORBS1/AGL/SLC35B4/DDB1/SLC5A3/FBP1/IDH1/AKR1B1/TPI1/PMAIP1/PGP/IL6ST/IGF2/BAD/PHKB/FAM3C/UGP2/GK 20 GO:0007040 lysosome organization 6/1165 74/18722 0.312606359672897 0.54475613065631 SYT7/LAPTM5/MYO7A/TMEM165/CLN3/GRN 6 GO:0046323 glucose import 6/1165 74/18722 0.312606359672897 0.54475613065631 SLC2A1/SORBS1/GPC3/SLC2A3/OPN3/PEA15 6 GO:0080171 lytic vacuole organization 6/1165 74/18722 0.312606359672897 0.54475613065631 SYT7/LAPTM5/MYO7A/TMEM165/CLN3/GRN 6 GO:0051259 protein complex oligomerization 17/1165 238/18722 0.313246246294605 0.545701794056989 B2M/SOD2/ALDOA/ISG15/SLC9A1/KCNG1/HLA-DRB1/CD74/FUS/PYCARD/GBP5/STOML2/RNF213/VASP/SSBP1/KCTD12/PRMT1 17 GO:0046328 regulation of JNK cascade 10/1165 133/18722 0.314734341169245 0.548124063600054 EGFR/APP/MARVELD3/IGF1R/NCF1/PDCD4/GSTP1/PYCARD/GADD45G/HRAS 10 GO:0001935 endothelial cell proliferation 14/1165 193/18722 0.315439274952239 0.549172598495049 NR2F2/GJA1/NRP2/CYBA/FLT1/NRP1/APOE/STAT1/DLG1/VEGFA/MYDGF/IGF2/PDCD6/NR4A1 14 GO:0050905 neuromuscular process 11/1165 148/18722 0.31553209159924 0.549172598495049 IGDCC3/APP/TMEM150C/MYO7A/PNKD/SLC1A3/GSTO1/C12orf57/CLN3/GCH1/NR4A1 11 GO:0006109 regulation of carbohydrate metabolic process 13/1165 178/18722 0.315783098297473 0.549371681301303 PHLDA2/SORBS1/APP/SLC35B4/DDB1/FBP1/PMAIP1/PGP/CLTC/TGFB1/IGF2/BAD/FAM3C 13 GO:0006633 fatty acid biosynthetic process 12/1165 163/18722 0.315842226181953 0.549371681301303 ACSS1/HACD3/PTGES/MGLL/DEGS1/GSTP1/NDUFAB1/APOC1/TECR/CD74/GPX4/ACADVL 12 GO:0018205 peptidyl-lysine modification 26/1165 376/18722 0.316548709706797 0.550429958979012 ISL1/GATA3/GCSH/CBX4/HINT1/BRD4/DNMT1/TGM2/MORF4L2/SOX4/HINT2/SPI1/USP22/NDUFAB1/RUVBL1/BRD7/GNL3/SMYD2/MDM2/NCOA3/PARK7/RTF1/HDAC2/MORF4L1/SET/PHF20 26 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 5/1165 60/18722 0.317410974551618 0.551246225296483 NFKBIA/C1QBP/IRF7/PHB/OASL 5 GO:0006289 nucleotide-excision repair 5/1165 60/18722 0.317410974551618 0.551246225296483 DDB1/RPA3/RAD23B/POLR2I/HMGN1 5 GO:0030071 regulation of mitotic metaphase/anaphase transition 5/1165 60/18722 0.317410974551618 0.551246225296483 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0055008 cardiac muscle tissue morphogenesis 5/1165 60/18722 0.317410974551618 0.551246225296483 LRP2/TGFBR3/DSP/ISL1/TGFB1 5 GO:0006892 post-Golgi vesicle-mediated transport 8/1165 104/18722 0.320265334075788 0.552914681312098 KRT18/ANK3/LAPTM5/VAMP5/GOLGA4/RABEP1/CLN3/SORL1 8 GO:0032984 protein-containing complex disassembly 16/1165 224/18722 0.320455529333398 0.552914681312098 SCIN/DSTN/IGF1R/LIMA1/RPL23/VCP/EPS8/CIB1/TRIOBP/STMN1/VMP1/ADD3/SET/CLN3/BNIP3/HSPA8 16 GO:0003180 aortic valve morphogenesis 3/1165 32/18722 0.320764636413983 0.552914681312098 GATA3/EFNA1/TGFB1 3 GO:0006026 aminoglycan catabolic process 3/1165 32/18722 0.320764636413983 0.552914681312098 CD44/FUCA1/TGFB1 3 GO:0009954 proximal/distal pattern formation 3/1165 32/18722 0.320764636413983 0.552914681312098 PBX1/GLI3/IRX2 3 GO:0014044 Schwann cell development 3/1165 32/18722 0.320764636413983 0.552914681312098 ITGB4/DAG1/SOD1 3 GO:0019835 cytolysis 3/1165 32/18722 0.320764636413983 0.552914681312098 LYZ/TGFB1/ROMO1 3 GO:0021799 cerebral cortex radially oriented cell migration 3/1165 32/18722 0.320764636413983 0.552914681312098 ADGRG1/LAMB1/GLI3 3 GO:0030431 sleep 3/1165 32/18722 0.320764636413983 0.552914681312098 ADRB1/FOS/SLC29A1 3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 3/1165 32/18722 0.320764636413983 0.552914681312098 NR2F2/CDKN1C/LATS2 3 GO:0046475 glycerophospholipid catabolic process 3/1165 32/18722 0.320764636413983 0.552914681312098 APOC1/GPCPD1/PRDX6 3 GO:0060323 head morphogenesis 3/1165 32/18722 0.320764636413983 0.552914681312098 ARID5B/DLX5/RRAS 3 GO:0060914 heart formation 3/1165 32/18722 0.320764636413983 0.552914681312098 LRP2/ISL1/FOLR1 3 GO:0071875 adrenergic receptor signaling pathway 3/1165 32/18722 0.320764636413983 0.552914681312098 ADRB1/ATP2B4/GNAI2 3 GO:0072525 pyridine-containing compound biosynthetic process 3/1165 32/18722 0.320764636413983 0.552914681312098 QPRT/KYNU/PARP9 3 GO:1901532 regulation of hematopoietic progenitor cell differentiation 3/1165 32/18722 0.320764636413983 0.552914681312098 PRKDC/DHX36/SPI1 3 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/1165 32/18722 0.320764636413983 0.552914681312098 PMAIP1/PARK7/ERP29 3 GO:2000191 regulation of fatty acid transport 3/1165 32/18722 0.320764636413983 0.552914681312098 PTGES/FIS1/SYK 3 GO:0006195 purine nucleotide catabolic process 4/1165 46/18722 0.320834334051934 0.552914681312098 HINT1/NUDT4/DNPH1/PNP 4 GO:0006383 transcription by RNA polymerase III 4/1165 46/18722 0.320834334051934 0.552914681312098 POLR2L/PRDX5/DHX36/POLR2K 4 GO:0033047 regulation of mitotic sister chromatid segregation 4/1165 46/18722 0.320834334051934 0.552914681312098 DUSP1/CENPF/RAD21/CCNB1 4 GO:0045851 pH reduction 4/1165 46/18722 0.320834334051934 0.552914681312098 ATP6V1B1/SLC11A1/CLN3/GRN 4 GO:0061028 establishment of endothelial barrier 4/1165 46/18722 0.320834334051934 0.552914681312098 TJP1/PECAM1/VEGFA/MSN 4 GO:0061462 protein localization to lysosome 4/1165 46/18722 0.320834334051934 0.552914681312098 LAPTM5/LAMTOR5/HSPA8/SORL1 4 GO:0070828 heterochromatin organization 4/1165 46/18722 0.320834334051934 0.552914681312098 HELLS/DNMT1/DNMT3A/MBD2 4 GO:0001936 regulation of endothelial cell proliferation 13/1165 179/18722 0.322891024664642 0.556288312290557 NR2F2/GJA1/NRP2/CYBA/FLT1/NRP1/APOE/STAT1/VEGFA/MYDGF/IGF2/PDCD6/NR4A1 13 GO:0032368 regulation of lipid transport 11/1165 149/18722 0.323340618709859 0.556721132766393 PTGES/DBI/NFKBIA/APOE/APOC1/TREM2/RETN/FIS1/TSPO/SYK/LRP1 11 GO:0045834 positive regulation of lipid metabolic process 11/1165 149/18722 0.323340618709859 0.556721132766393 SORBS1/FLT1/APOE/VAV3/APOC1/CD74/TGFB1/STOML2/FGR/CGA/LYN 11 GO:2001259 positive regulation of cation channel activity 6/1165 75/18722 0.323734454684393 0.557228302405244 CTSS/TMSB4X/ANK3/IFNGR2/GSTO1/TREM2 6 GO:0043547 positive regulation of GTPase activity 18/1165 255/18722 0.324119979810214 0.557720860415306 ITGA6/ADRB1/SYDE2/DOCK9/RASA1/FERMT2/S100A10/NET1/ITGB1/TGM2/CCL3L3/LIMS1/EIF5/HRAS/DOCK10/RGS10/CCL4/RHOG 18 GO:0006913 nucleocytoplasmic transport 21/1165 301/18722 0.325133941774165 0.559122798767889 CDH1/FERMT1/PTPN14/GLI3/HSP90AB1/RPL23/NFKBIA/NPM1/FLNA/MX2/RAN/TGFB1/MDM2/TXNIP/PARK7/CALR/TNPO1/YWHAE/SYK/JAK2/NUP214 21 GO:0051169 nuclear transport 21/1165 301/18722 0.325133941774165 0.559122798767889 CDH1/FERMT1/PTPN14/GLI3/HSP90AB1/RPL23/NFKBIA/NPM1/FLNA/MX2/RAN/TGFB1/MDM2/TXNIP/PARK7/CALR/TNPO1/YWHAE/SYK/JAK2/NUP214 21 GO:0097581 lamellipodium organization 7/1165 90/18722 0.327492991956335 0.56300709459446 KANK1/CD44/ITGB1/VAV3/WASF2/PLEKHO1/ABI3 7 GO:0043030 regulation of macrophage activation 5/1165 61/18722 0.329887244060022 0.566467423714352 HSPD1/PTPRC/CD74/TREM2/GRN 5 GO:0060997 dendritic spine morphogenesis 5/1165 61/18722 0.329887244060022 0.566467423714352 EFNA1/DHX36/WASL/DOCK10/ABI3 5 GO:0060998 regulation of dendritic spine development 5/1165 61/18722 0.329887244060022 0.566467423714352 DLG5/EFNA1/APOE/DHX36/HDAC2 5 GO:0003085 negative regulation of systemic arterial blood pressure 2/1165 19/18722 0.333038036390052 0.566467423714352 ADRB1/SOD2 2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/1165 19/18722 0.333038036390052 0.566467423714352 SOX4/MDM2 2 GO:0007603 phototransduction, visible light 2/1165 19/18722 0.333038036390052 0.566467423714352 GNA11/NMT1 2 GO:0008356 asymmetric cell division 2/1165 19/18722 0.333038036390052 0.566467423714352 ASPM/ETV5 2 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 2/1165 19/18722 0.333038036390052 0.566467423714352 TYMS/NME1 2 GO:0010002 cardioblast differentiation 2/1165 19/18722 0.333038036390052 0.566467423714352 ISL1/DHX36 2 GO:0010544 negative regulation of platelet activation 2/1165 19/18722 0.333038036390052 0.566467423714352 APOE/CD9 2 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 2/1165 19/18722 0.333038036390052 0.566467423714352 KLF4/TREM2 2 GO:0032695 negative regulation of interleukin-12 production 2/1165 19/18722 0.333038036390052 0.566467423714352 C1QBP/LILRB1 2 GO:0035313 wound healing, spreading of epidermal cells 2/1165 19/18722 0.333038036390052 0.566467423714352 FERMT1/FERMT2 2 GO:0036498 IRE1-mediated unfolded protein response 2/1165 19/18722 0.333038036390052 0.566467423714352 HSPA5/UFL1 2 GO:0043031 negative regulation of macrophage activation 2/1165 19/18722 0.333038036390052 0.566467423714352 PTPRC/GRN 2 GO:0044546 NLRP3 inflammasome complex assembly 2/1165 19/18722 0.333038036390052 0.566467423714352 GBP5/TREM2 2 GO:0045019 negative regulation of nitric oxide biosynthetic process 2/1165 19/18722 0.333038036390052 0.566467423714352 ATP2B4/TSPO 2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/1165 19/18722 0.333038036390052 0.566467423714352 APOBEC3A/TOP2A 2 GO:0045947 negative regulation of translational initiation 2/1165 19/18722 0.333038036390052 0.566467423714352 EIF2AK1/EIF2AK4 2 GO:0046033 AMP metabolic process 2/1165 19/18722 0.333038036390052 0.566467423714352 AK3/ADK 2 GO:0046716 muscle cell cellular homeostasis 2/1165 19/18722 0.333038036390052 0.566467423714352 ALDOA/SOD1 2 GO:0046782 regulation of viral transcription 2/1165 19/18722 0.333038036390052 0.566467423714352 IFITM3/ZFP36 2 GO:0046794 transport of virus 2/1165 19/18722 0.333038036390052 0.566467423714352 CTSL/BST2 2 GO:0048245 eosinophil chemotaxis 2/1165 19/18722 0.333038036390052 0.566467423714352 LGALS3/CCL4 2 GO:0050961 detection of temperature stimulus involved in sensory perception 2/1165 19/18722 0.333038036390052 0.566467423714352 CXCR4/NR2F6 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/1165 19/18722 0.333038036390052 0.566467423714352 DNMT1/RTF1 2 GO:0060216 definitive hemopoiesis 2/1165 19/18722 0.333038036390052 0.566467423714352 TGFBR3/MFAP5 2 GO:0061323 cell proliferation involved in heart morphogenesis 2/1165 19/18722 0.333038036390052 0.566467423714352 ISL1/TBX3 2 GO:0061760 antifungal innate immune response 2/1165 19/18722 0.333038036390052 0.566467423714352 CLEC4E/SPI1 2 GO:0070233 negative regulation of T cell apoptotic process 2/1165 19/18722 0.333038036390052 0.566467423714352 EFNA1/TSC22D3 2 GO:0070262 peptidyl-serine dephosphorylation 2/1165 19/18722 0.333038036390052 0.566467423714352 DUSP1/YWHAE 2 GO:0097501 stress response to metal ion 2/1165 19/18722 0.333038036390052 0.566467423714352 HSPA5/PARK7 2 GO:1901659 glycosyl compound biosynthetic process 2/1165 19/18722 0.333038036390052 0.566467423714352 ADK/PNP 2 GO:1903975 regulation of glial cell migration 2/1165 19/18722 0.333038036390052 0.566467423714352 TREM2/LRP1 2 GO:1904406 negative regulation of nitric oxide metabolic process 2/1165 19/18722 0.333038036390052 0.566467423714352 ATP2B4/TSPO 2 GO:0042180 cellular ketone metabolic process 15/1165 211/18722 0.33465057961792 0.56896938379442 HSD17B1/COMT/AKR1B1/TPI1/COQ4/PNKD/APOC1/ATP2B4/CD74/NMT1/PARK7/KYNU/CLN3/ACADVL/SLC7A7 15 GO:0043536 positive regulation of blood vessel endothelial cell migration 6/1165 76/18722 0.334916344852155 0.56896938379442 TMSB4X/NRP1/VEGFA/PIK3C2A/CIB1/TGFB1 6 GO:0009261 ribonucleotide catabolic process 4/1165 47/18722 0.335218555533253 0.56896938379442 HINT1/NUDT4/UPP1/PNP 4 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 4/1165 47/18722 0.335218555533253 0.56896938379442 LAPTM5/GSTP1/PYCARD/SYK 4 GO:0035315 hair cell differentiation 4/1165 47/18722 0.335218555533253 0.56896938379442 ESRP1/SOD1/MYO7A/TRIOBP 4 GO:0051489 regulation of filopodium assembly 4/1165 47/18722 0.335218555533253 0.56896938379442 NRP1/FNBP1L/WASL/CLN3 4 GO:1903170 negative regulation of calcium ion transmembrane transport 4/1165 47/18722 0.335218555533253 0.56896938379442 C4orf3/GSTO1/YWHAE/VDAC1 4 GO:0045664 regulation of neuron differentiation 14/1165 196/18722 0.335998567661675 0.570120906978531 PBX1/BMP7/SLC6A4/ISL1/B2M/ESRP1/APP/GLI3/ASPM/NREP/RHOA/ETV5/EIF2AK4/CALR 14 GO:1905952 regulation of lipid localization 13/1165 181/18722 0.337216479626977 0.571733511712859 PTGES/HILPDA/DBI/NFKBIA/APOE/APOC1/PLIN2/TREM2/RETN/FIS1/TSPO/SYK/LRP1 13 GO:0051983 regulation of chromosome segregation 7/1165 91/18722 0.337707262005976 0.571733511712859 DUSP1/PLSCR1/ANAPC11/MKI67/CENPF/RAD21/CCNB1 7 GO:0003382 epithelial cell morphogenesis 3/1165 33/18722 0.338171255814483 0.571733511712859 MET/SPINT2/RAB25 3 GO:0010165 response to X-ray 3/1165 33/18722 0.338171255814483 0.571733511712859 GATA3/CCND1/NUCKS1 3 GO:0010259 multicellular organism aging 3/1165 33/18722 0.338171255814483 0.571733511712859 CTSV/TFCP2L1/SERP1 3 GO:0019362 pyridine nucleotide metabolic process 3/1165 33/18722 0.338171255814483 0.571733511712859 QPRT/KYNU/PARP9 3 GO:0046496 nicotinamide nucleotide metabolic process 3/1165 33/18722 0.338171255814483 0.571733511712859 QPRT/KYNU/PARP9 3 GO:0060122 inner ear receptor cell stereocilium organization 3/1165 33/18722 0.338171255814483 0.571733511712859 SOD1/MYO7A/TRIOBP 3 GO:0071539 protein localization to centrosome 3/1165 33/18722 0.338171255814483 0.571733511712859 SNX10/GOLGB1/PCM1 3 GO:0099084 postsynaptic specialization organization 3/1165 33/18722 0.338171255814483 0.571733511712859 DLG1/LILRB2/ABI3 3 GO:1902275 regulation of chromatin organization 3/1165 33/18722 0.338171255814483 0.571733511712859 DNMT1/TLK1/MKI67 3 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 3/1165 33/18722 0.338171255814483 0.571733511712859 NR2F2/CDKN1C/LATS2 3 GO:0043535 regulation of blood vessel endothelial cell migration 11/1165 151/18722 0.339079158513513 0.57300952508457 TMSB4X/EFNA1/NRP1/APOE/RHOA/VEGFA/PIK3C2A/KLF4/ATP2B4/CIB1/TGFB1 11 GO:0001824 blastocyst development 8/1165 106/18722 0.339130169665231 0.57300952508457 YAP1/NASP/SKIL/KLF4/JUNB/RTF1/SF3B6/PSMC4 8 GO:0098876 vesicle-mediated transport to the plasma membrane 10/1165 136/18722 0.339585006204722 0.573389732623973 KRT18/NSG1/ANK3/VAMP5/GOLGA4/RABEP1/CLN3/RAB11A/SNX3/SORL1 10 GO:0002455 humoral immune response mediated by circulating immunoglobulin 9/1165 121/18722 0.33966165347848 0.573389732623973 C1QA/C1QB/C1QC/PTPRC/C1QBP/CD55/CD46/PTPN6/TREM2 9 GO:0042752 regulation of circadian rhythm 9/1165 121/18722 0.33966165347848 0.573389732623973 MAGED1/ADRB1/NR2F6/DDB1/GNA11/SIAH2/PRKDC/OPN3/TOP2A 9 GO:0030258 lipid modification 15/1165 212/18722 0.341305985697256 0.575992332446992 SLC27A2/ECHDC2/PLPP3/ADH5/APOE/ECHS1/ECI1/ECI2/APOC1/ETFA/ST3GAL4/ECH1/HADHB/ACADVL/ECHDC1 15 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 5/1165 62/18722 0.342409070472233 0.576813359111837 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0010573 vascular endothelial growth factor production 5/1165 62/18722 0.342409070472233 0.576813359111837 ADGRG1/ISL1/IL6ST/TGFB1/SULF2 5 GO:0031124 mRNA 3'-end processing 5/1165 62/18722 0.342409070472233 0.576813359111837 APP/DHX36/PABPC1/ZFP36L1/CCNB1 5 GO:0046148 pigment biosynthetic process 5/1165 62/18722 0.342409070472233 0.576813359111837 PAICS/OPN3/TSPO/UROD/ZEB2 5 GO:0046847 filopodium assembly 5/1165 62/18722 0.342409070472233 0.576813359111837 ITGB4/NRP1/FNBP1L/WASL/CLN3 5 GO:1902750 negative regulation of cell cycle G2/M phase transition 5/1165 62/18722 0.342409070472233 0.576813359111837 FOXO4/ATF5/USP47/RAD21/BABAM1 5 GO:0060401 cytosolic calcium ion transport 13/1165 182/18722 0.34442861033952 0.580041341084826 CYBA/ATP2B1/PTPRC/AFG3L2/ATP2B4/PTPN6/GSTO1/ERO1A/CXCL10/YWHAE/SLC8A1/VDAC1/LYN 13 GO:0007254 JNK cascade 12/1165 167/18722 0.345806521932372 0.582187164848951 EGFR/HACD3/DUSP9/APP/MARVELD3/IGF1R/NCF1/PDCD4/GSTP1/PYCARD/GADD45G/HRAS 12 GO:0002200 somatic diversification of immune receptors 6/1165 77/18722 0.346141700149171 0.582402087211419 HSPD1/TFRC/PRKDC/PTPRC/TGFB1/CTNNBL1 6 GO:0032418 lysosome localization 6/1165 77/18722 0.346141700149171 0.582402087211419 STXBP2/S100A13/FGR/SYK/CD300A/LYN 6 GO:0006310 DNA recombination 21/1165 305/18722 0.347301421072215 0.584178266849969 HSPD1/PARP1/TFRC/MCM3/PSMD14/MCM6/MAGEF1/PRKDC/PTPRC/MCM7/RUVBL1/FUS/RAD50/NUCKS1/HMGB3/TGFB1/RPA3/MORF4L1/RAD21/APEX1/TOP2A 21 GO:0001708 cell fate specification 7/1165 92/18722 0.347962862944664 0.584940266459538 ISL1/ESRP1/LMO4/GLI3/TBX3/NRP1/ITGB1 7 GO:1903351 cellular response to dopamine 7/1165 92/18722 0.347962862944664 0.584940266459538 NSG1/GNAS/ID1/GNA11/TGM2/FLNA/HDAC2 7 GO:0019730 antimicrobial humoral response 9/1165 122/18722 0.34853803070367 0.585351642874369 LYZ/HLA-A/HLA-E/GAPDH/SLC11A1/S100A12/CXCL10/ROMO1/DEFB1 9 GO:0051928 positive regulation of calcium ion transport 9/1165 122/18722 0.34853803070367 0.585351642874369 SLC9A1/ATP2B1/LGALS3/GSTO1/VMP1/CXCL10/CCL4/TSPO/LILRA2 9 GO:0006275 regulation of DNA replication 8/1165 107/18722 0.348624717999112 0.585351642874369 EGFR/NUCKS1/STOML2/HRAS/SSBP1/GMNN/JUN/SMC3 8 GO:0051341 regulation of oxidoreductase activity 8/1165 107/18722 0.348624717999112 0.585351642874369 EGFR/CYBA/APOE/ATP2B4/PARK7/GNAI2/GCH1/NDUFA4 8 GO:0002686 negative regulation of leukocyte migration 4/1165 48/18722 0.349628299948635 0.586685694353269 DPP4/DUSP1/WASL/CD300A 4 GO:0097720 calcineurin-mediated signaling 4/1165 48/18722 0.349628299948635 0.586685694353269 SLC9A1/ATP2B4/CIB1/NFAT5 4 GO:0048167 regulation of synaptic plasticity 14/1165 198/18722 0.349863541349284 0.58690497836029 MME/NSG1/TYROBP/APP/PRKCZ/SYT7/APOE/PTN/LGMN/EIF2AK4/LILRB2/HRAS/CLN3/RAB11A 14 GO:0016482 cytosolic transport 12/1165 168/18722 0.353380620768653 0.590819420831662 SYT7/RHOBTB3/LAPTM5/DAB2/FLNA/CLTC/MSN/ARL1/SNX6/CLN3/SNX3/SORL1 12 GO:0072330 monocarboxylic acid biosynthetic process 15/1165 214/18722 0.35469823316889 0.590819420831662 SLC27A2/ACSS1/HACD3/PTGES/MGLL/DEGS1/GSTP1/NDUFAB1/APOC1/TECR/CD74/OSBPL9/GPX4/PARK7/ACADVL 15 GO:0007338 single fertilization 11/1165 153/18722 0.354955746680678 0.590819420831662 SPESP1/FOLR1/ALDOA/SLIRP/PITHD1/CCT2/CD9/SNU13/CD46/PARK7/LHFPL2 11 GO:0030239 myofibril assembly 5/1165 63/18722 0.35496236689945 0.590819420831662 KRT8/OBSL1/CSRP2/ITGB1/KRT19 5 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 5/1165 63/18722 0.35496236689945 0.590819420831662 CEBPB/PMAIP1/PARK7/ERO1A/ERP29 5 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 5/1165 63/18722 0.35496236689945 0.590819420831662 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0000038 very long-chain fatty acid metabolic process 3/1165 34/18722 0.355548792025492 0.590819420831662 SLC27A2/HACD3/TECR 3 GO:0007616 long-term memory 3/1165 34/18722 0.355548792025492 0.590819420831662 PRKCZ/APOE/EIF2AK4 3 GO:0009112 nucleobase metabolic process 3/1165 34/18722 0.355548792025492 0.590819420831662 TYMP/PAICS/TYMS 3 GO:0010661 positive regulation of muscle cell apoptotic process 3/1165 34/18722 0.355548792025492 0.590819420831662 SOD2/PDCD4/BNIP3 3 GO:0030851 granulocyte differentiation 3/1165 34/18722 0.355548792025492 0.590819420831662 C1QC/EVI2B/SPI1 3 GO:0032770 positive regulation of monooxygenase activity 3/1165 34/18722 0.355548792025492 0.590819420831662 APOE/PARK7/GCH1 3 GO:0050931 pigment cell differentiation 3/1165 34/18722 0.355548792025492 0.590819420831662 GLI3/GNA11/ZEB2 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/1165 34/18722 0.355548792025492 0.590819420831662 GJA5/GJA1/FLNA 3 GO:0051480 regulation of cytosolic calcium ion concentration 24/1165 353/18722 0.356176583971543 0.590819420831662 GJA1/CXCR4/CYBA/CD24/ATP2B1/TGM2/PTPRC/CD55/ATP2B4/PTPN6/CD52/GSTO1/FPR1/FPR3/ERO1A/CXCL10/YWHAE/S1PR4/FIS1/CLN3/SLC8A1/LRP1/JAK2/LYN 24 GO:0006590 thyroid hormone generation 2/1165 20/18722 0.356196850186058 0.590819420831662 GATA3/CGA 2 GO:0006700 C21-steroid hormone biosynthetic process 2/1165 20/18722 0.356196850186058 0.590819420831662 AKR1B1/TSPO 2 GO:0006896 Golgi to vacuole transport 2/1165 20/18722 0.356196850186058 0.590819420831662 LAPTM5/CLN3 2 GO:0007097 nuclear migration 2/1165 20/18722 0.356196850186058 0.590819420831662 SYNE2/PCM1 2 GO:0007194 negative regulation of adenylate cyclase activity 2/1165 20/18722 0.356196850186058 0.590819420831662 AKAP9/GNAI2 2 GO:0016553 base conversion or substitution editing 2/1165 20/18722 0.356196850186058 0.590819420831662 APOBEC3A/RBM47 2 GO:0032495 response to muramyl dipeptide 2/1165 20/18722 0.356196850186058 0.590819420831662 NFKBIA/VIM 2 GO:0032986 protein-DNA complex disassembly 2/1165 20/18722 0.356196850186058 0.590819420831662 RPL23/SET 2 GO:0033005 positive regulation of mast cell activation 2/1165 20/18722 0.356196850186058 0.590819420831662 FGR/SYK 2 GO:0039535 regulation of RIG-I signaling pathway 2/1165 20/18722 0.356196850186058 0.590819420831662 C1QBP/OASL 2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/1165 20/18722 0.356196850186058 0.590819420831662 APOBEC3A/TOP2A 2 GO:0042359 vitamin D metabolic process 2/1165 20/18722 0.356196850186058 0.590819420831662 LRP2/LGMN 2 GO:0043011 myeloid dendritic cell differentiation 2/1165 20/18722 0.356196850186058 0.590819420831662 ITGB8/SPI1 2 GO:0048025 negative regulation of mRNA splicing, via spliceosome 2/1165 20/18722 0.356196850186058 0.590819420831662 NPM1/C1QBP 2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 2/1165 20/18722 0.356196850186058 0.590819420831662 ISG15/OAS1 2 GO:0061318 renal filtration cell differentiation 2/1165 20/18722 0.356196850186058 0.590819420831662 CD24/BASP1 2 GO:0072112 glomerular visceral epithelial cell differentiation 2/1165 20/18722 0.356196850186058 0.590819420831662 CD24/BASP1 2 GO:0097150 neuronal stem cell population maintenance 2/1165 20/18722 0.356196850186058 0.590819420831662 ASPM/PCM1 2 GO:0097320 plasma membrane tubulation 2/1165 20/18722 0.356196850186058 0.590819420831662 FNBP1L/WASL 2 GO:0140632 inflammasome complex assembly 2/1165 20/18722 0.356196850186058 0.590819420831662 GBP5/TREM2 2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/1165 20/18722 0.356196850186058 0.590819420831662 MET/PARK7 2 GO:2000010 positive regulation of protein localization to cell surface 2/1165 20/18722 0.356196850186058 0.590819420831662 TYROBP/HSP90AB1 2 GO:2000479 regulation of cAMP-dependent protein kinase activity 2/1165 20/18722 0.356196850186058 0.590819420831662 PKIB/ATP2B4 2 GO:0032371 regulation of sterol transport 6/1165 78/18722 0.357400352550557 0.592290575396007 NFKBIA/APOE/APOC1/TREM2/TSPO/LRP1 6 GO:0032374 regulation of cholesterol transport 6/1165 78/18722 0.357400352550557 0.592290575396007 NFKBIA/APOE/APOC1/TREM2/TSPO/LRP1 6 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 6/1165 78/18722 0.357400352550557 0.592290575396007 NRP1/RHOA/VEGFA/PIK3C2A/KLF4/CIB1 6 GO:1903350 response to dopamine 7/1165 93/18722 0.358252030880395 0.593526756001079 NSG1/GNAS/ID1/GNA11/TGM2/FLNA/HDAC2 7 GO:0000959 mitochondrial RNA metabolic process 4/1165 49/18722 0.364043085794 0.600992306047565 SLIRP/TFAM/LRPPRC/MRPL12 4 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 4/1165 49/18722 0.364043085794 0.600992306047565 HSPD1/TFRC/PTPRC/TGFB1 4 GO:0002208 somatic diversification of immunoglobulins involved in immune response 4/1165 49/18722 0.364043085794 0.600992306047565 HSPD1/TFRC/PTPRC/TGFB1 4 GO:0006778 porphyrin-containing compound metabolic process 4/1165 49/18722 0.364043085794 0.600992306047565 EIF2AK1/SLCO2B1/TSPO/UROD 4 GO:0008038 neuron recognition 4/1165 49/18722 0.364043085794 0.600992306047565 CXCR4/APP/NRP1/BSG 4 GO:0009395 phospholipid catabolic process 4/1165 49/18722 0.364043085794 0.600992306047565 IDH1/APOC1/GPCPD1/PRDX6 4 GO:0021515 cell differentiation in spinal cord 4/1165 49/18722 0.364043085794 0.600992306047565 ISL1/LMO4/GLI3/SOX4 4 GO:0045190 isotype switching 4/1165 49/18722 0.364043085794 0.600992306047565 HSPD1/TFRC/PTPRC/TGFB1 4 GO:0051445 regulation of meiotic cell cycle 4/1165 49/18722 0.364043085794 0.600992306047565 ASPM/DUSP1/PRKACB/CALR 4 GO:0072666 establishment of protein localization to vacuole 4/1165 49/18722 0.364043085794 0.600992306047565 LAPTM5/VPS25/HSPA8/SORL1 4 GO:0086009 membrane repolarization 4/1165 49/18722 0.364043085794 0.600992306047565 GJA5/FLNA/AKAP9/YWHAE 4 GO:1904752 regulation of vascular associated smooth muscle cell migration 4/1165 49/18722 0.364043085794 0.600992306047565 ADAMTS1/RHOA/MDM2/LRP1 4 GO:0045995 regulation of embryonic development 5/1165 64/18722 0.367533406324539 0.606219515045441 LAMA5/DAG1/PHLDA2/AMOT/DHX36 5 GO:0048247 lymphocyte chemotaxis 5/1165 64/18722 0.367533406324539 0.606219515045441 CCL3L3/CXCL10/CXCL16/CCL4/ADAM8 5 GO:0055002 striated muscle cell development 5/1165 64/18722 0.367533406324539 0.606219515045441 KRT8/OBSL1/CSRP2/ITGB1/KRT19 5 GO:0001895 retina homeostasis 6/1165 79/18722 0.368682316195685 0.607400599003928 LYZ/SLC2A1/B2M/SOD1/PRDX1/ACTB 6 GO:0050772 positive regulation of axonogenesis 6/1165 79/18722 0.368682316195685 0.607400599003928 NRP1/GOLGA4/VEGFA/SKIL/RAB11A/LRP1 6 GO:0051279 regulation of release of sequestered calcium ion into cytosol 6/1165 79/18722 0.368682316195685 0.607400599003928 CYBA/PTPN6/GSTO1/CXCL10/SLC8A1/LYN 6 GO:0060420 regulation of heart growth 6/1165 79/18722 0.368682316195685 0.607400599003928 TGFBR3/GJA1/DUSP9/YAP1/BASP1/CCNB1 6 GO:0006403 RNA localization 14/1165 201/18722 0.370851342214335 0.610764398480064 IGF2BP3/NPM1/ZFP36/NCBP3/CCT2/DHX36/MX2/RAN/RUVBL1/LRPPRC/YBX1/NHP2/ZFP36L1/NUP214 14 GO:0010970 transport along microtubule 11/1165 155/18722 0.370941712884115 0.610764398480064 APP/PRKCZ/SOD1/UBB/ARMCX3/HSPB11/LRPPRC/DST/PCM1/CLN3/HSPA8 11 GO:0006402 mRNA catabolic process 16/1165 232/18722 0.372084034678345 0.611240577685873 NPM1/ZFP36/VIM/LSM7/DHX36/FUS/SLC11A1/SERBP1/CARHSP1/PABPC1/YBX1/SND1/APEX1/ZFP36L1/PNRC2/CIRBP 16 GO:0006471 protein ADP-ribosylation 3/1165 35/18722 0.372864375199791 0.611240577685873 PARP1/ARF4/PARP9 3 GO:0006691 leukotriene metabolic process 3/1165 35/18722 0.372864375199791 0.611240577685873 MGST3/TLR2/SYK 3 GO:0006739 NADP metabolic process 3/1165 35/18722 0.372864375199791 0.611240577685873 RPIA/IDH1/DCXR 3 GO:0010837 regulation of keratinocyte proliferation 3/1165 35/18722 0.372864375199791 0.611240577685873 YAP1/ZFP36/ZFP36L1 3 GO:0015695 organic cation transport 3/1165 35/18722 0.372864375199791 0.611240577685873 SLC19A3/SLC44A2/SLC29A1 3 GO:0021955 central nervous system neuron axonogenesis 3/1165 35/18722 0.372864375199791 0.611240577685873 HSP90AB1/HSP90AA1/C12orf57 3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 3/1165 35/18722 0.372864375199791 0.611240577685873 HSP90AB1/USP14/PARK7 3 GO:0034331 cell junction maintenance 3/1165 35/18722 0.372864375199791 0.611240577685873 TJP1/FERMT2/DLG1 3 GO:0039694 viral RNA genome replication 3/1165 35/18722 0.372864375199791 0.611240577685873 APOBEC3A/PHB/TOP2A 3 GO:0043243 positive regulation of protein-containing complex disassembly 3/1165 35/18722 0.372864375199791 0.611240577685873 DSTN/IGF1R/BNIP3 3 GO:0046627 negative regulation of insulin receptor signaling pathway 3/1165 35/18722 0.372864375199791 0.611240577685873 KANK1/PRKCZ/SOCS3 3 GO:0090181 regulation of cholesterol metabolic process 3/1165 35/18722 0.372864375199791 0.611240577685873 SOD1/APOE/ACADVL 3 GO:1905207 regulation of cardiocyte differentiation 3/1165 35/18722 0.372864375199791 0.611240577685873 EGFR/DHX36/TGFB1 3 GO:1905508 protein localization to microtubule organizing center 3/1165 35/18722 0.372864375199791 0.611240577685873 SNX10/GOLGB1/PCM1 3 GO:0009063 cellular amino acid catabolic process 8/1165 110/18722 0.377283086540621 0.61503342804834 GLDC/GCSH/ECHS1/CDO1/IL4I1/ATP2B4/KYNU/GLUL 8 GO:0061387 regulation of extent of cell growth 8/1165 110/18722 0.377283086540621 0.61503342804834 SEMA6A/SEMA6D/NRP1/APOE/GOLGA4/VEGFA/RAB11A/LRP1 8 GO:1904659 glucose transmembrane transport 8/1165 110/18722 0.377283086540621 0.61503342804834 SLC2A1/SORBS1/GPC3/SLC5A3/YES1/SLC2A3/OPN3/PEA15 8 GO:0060425 lung morphogenesis 4/1165 50/18722 0.378443271549855 0.61503342804834 DAG1/DLG5/YAP1/CTSH 4 GO:1904738 vascular associated smooth muscle cell migration 4/1165 50/18722 0.378443271549855 0.61503342804834 ADAMTS1/RHOA/MDM2/LRP1 4 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 16/1165 233/18722 0.378636827186268 0.61503342804834 ADGRG1/LGR5/LGR4/ADRB1/GNAI1/GNAS/GNA11/PRKACB/FLNA/ATP2B4/WASF2/FPR1/GNAI2/CXCL10/S1PR4/ADGRE5 16 GO:0008593 regulation of Notch signaling pathway 7/1165 95/18722 0.37890051948397 0.61503342804834 BMP7/AAK1/GALNT11/YAP1/NFKBIA/CD46/IL6ST 7 GO:0001764 neuron migration 11/1165 156/18722 0.378966800708012 0.61503342804834 SEMA6A/ADGRG1/NR2F2/CXCR4/NRP2/GATA3/ASPM/NRP1/VEGFA/FLNA/PCM1 11 GO:0002689 negative regulation of leukocyte chemotaxis 2/1165 21/18722 0.379058600697861 0.61503342804834 DPP4/DUSP1 2 GO:0003177 pulmonary valve development 2/1165 21/18722 0.379058600697861 0.61503342804834 GJA5/TNFRSF1B 2 GO:0006450 regulation of translational fidelity 2/1165 21/18722 0.379058600697861 0.61503342804834 IARS2/RPS5 2 GO:0006925 inflammatory cell apoptotic process 2/1165 21/18722 0.379058600697861 0.61503342804834 CTSL/IRF7 2 GO:0007063 regulation of sister chromatid cohesion 2/1165 21/18722 0.379058600697861 0.61503342804834 NAA10/RAD21 2 GO:0007252 I-kappaB phosphorylation 2/1165 21/18722 0.379058600697861 0.61503342804834 PRDX4/TLR2 2 GO:0007617 mating behavior 2/1165 21/18722 0.379058600697861 0.61503342804834 APP/HDAC2 2 GO:0008090 retrograde axonal transport 2/1165 21/18722 0.379058600697861 0.61503342804834 SOD1/DST 2 GO:0019370 leukotriene biosynthetic process 2/1165 21/18722 0.379058600697861 0.61503342804834 MGST3/SYK 2 GO:0032303 regulation of icosanoid secretion 2/1165 21/18722 0.379058600697861 0.61503342804834 PTGES/SYK 2 GO:0033762 response to glucagon 2/1165 21/18722 0.379058600697861 0.61503342804834 ASS1/CDO1 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/1165 21/18722 0.379058600697861 0.61503342804834 SLC26A2/TPST2 2 GO:0035813 regulation of renal sodium excretion 2/1165 21/18722 0.379058600697861 0.61503342804834 COMT/GNAI2 2 GO:0044342 type B pancreatic cell proliferation 2/1165 21/18722 0.379058600697861 0.61503342804834 BAD/NR4A1 2 GO:0045717 negative regulation of fatty acid biosynthetic process 2/1165 21/18722 0.379058600697861 0.61503342804834 APOC1/ACADVL 2 GO:0046128 purine ribonucleoside metabolic process 2/1165 21/18722 0.379058600697861 0.61503342804834 ADK/PNP 2 GO:0046823 negative regulation of nucleocytoplasmic transport 2/1165 21/18722 0.379058600697861 0.61503342804834 FERMT1/PARK7 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/1165 21/18722 0.379058600697861 0.61503342804834 SLC26A2/TPST2 2 GO:0072311 glomerular epithelial cell differentiation 2/1165 21/18722 0.379058600697861 0.61503342804834 CD24/BASP1 2 GO:0090141 positive regulation of mitochondrial fission 2/1165 21/18722 0.379058600697861 0.61503342804834 FIS1/BNIP3 2 GO:0098719 sodium ion import across plasma membrane 2/1165 21/18722 0.379058600697861 0.61503342804834 SLC9A1/SLC8A1 2 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/1165 21/18722 0.379058600697861 0.61503342804834 SLC25A5/NMT1 2 GO:1902259 regulation of delayed rectifier potassium channel activity 2/1165 21/18722 0.379058600697861 0.61503342804834 ANK3/KCNG1 2 GO:1905209 positive regulation of cardiocyte differentiation 2/1165 21/18722 0.379058600697861 0.61503342804834 DHX36/TGFB1 2 GO:2000047 regulation of cell-cell adhesion mediated by cadherin 2/1165 21/18722 0.379058600697861 0.61503342804834 TJP1/VEGFA 2 GO:2001014 regulation of skeletal muscle cell differentiation 2/1165 21/18722 0.379058600697861 0.61503342804834 GPC1/UQCC2 2 GO:0021766 hippocampus development 6/1165 80/18722 0.379977805943552 0.61503342804834 CDK6/GLI3/UQCRQ/ANXA3/ATP2B4/NME1 6 GO:0032204 regulation of telomere maintenance 6/1165 80/18722 0.379977805943552 0.61503342804834 PKIB/PARP1/CCT2/DHX36/GNL3/RAD50 6 GO:1901264 carbohydrate derivative transport 6/1165 80/18722 0.379977805943552 0.61503342804834 GJA1/SLC19A1/SLC35B4/SLC25A5/SLC29A1/CLN3 6 GO:0010965 regulation of mitotic sister chromatid separation 5/1165 65/18722 0.38010884765717 0.61503342804834 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0015909 long-chain fatty acid transport 5/1165 65/18722 0.38010884765717 0.61503342804834 SLC27A2/SLC2A1/APOE/PLIN2/SYK 5 GO:0038034 signal transduction in absence of ligand 5/1165 65/18722 0.38010884765717 0.61503342804834 ERBB3/PRDX2/IFI6/BCL2A1/BAD 5 GO:0044784 metaphase/anaphase transition of cell cycle 5/1165 65/18722 0.38010884765717 0.61503342804834 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0045453 bone resorption 5/1165 65/18722 0.38010884765717 0.61503342804834 EGFR/TFRC/SNX10/SYK/ADAM8 5 GO:0046503 glycerolipid catabolic process 5/1165 65/18722 0.38010884765717 0.61503342804834 MGLL/APOC1/GPCPD1/PRDX6/SORL1 5 GO:0048645 animal organ formation 5/1165 65/18722 0.38010884765717 0.61503342804834 LRP2/BMP7/ISL1/FOLR1/GLI3 5 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 5/1165 65/18722 0.38010884765717 0.61503342804834 ERBB3/PRDX2/IFI6/BCL2A1/BAD 5 GO:0032874 positive regulation of stress-activated MAPK cascade 9/1165 126/18722 0.384318807753841 0.621666129084239 APP/NCF1/VEGFA/SPI1/PYCARD/ARL6IP5/GADD45G/HRAS/PRMT1 9 GO:0048588 developmental cell growth 16/1165 234/18722 0.385205256256259 0.622920513790372 SEMA6A/SEMA6D/CXCR4/APP/NRP2/PRKCZ/HSP90AB1/NRP1/APOE/HSP90AA1/ITGB1/GOLGA4/VEGFA/EIF2AK4/RAB11A/LRP1 16 GO:0001938 positive regulation of endothelial cell proliferation 8/1165 111/18722 0.38687397348958 0.625258742642388 NRP2/CYBA/NRP1/VEGFA/MYDGF/IGF2/PDCD6/NR4A1 8 GO:0015718 monocarboxylic acid transport 8/1165 111/18722 0.38687397348958 0.625258742642388 SLC16A12/PTGES/MPC2/SLC5A6/SLCO2B1/SLC16A3/SYK/AQP9 8 GO:0030308 negative regulation of cell growth 13/1165 188/18722 0.388222482115964 0.627257568254723 SEMA6A/SEMA6D/GJA1/RBBP7/NRP1/EI24/FBP1/SMARCA2/TGFB1/ENO1/PHB/BST2/NDUFS3 13 GO:0006637 acyl-CoA metabolic process 7/1165 96/18722 0.389244858819322 0.627825112802544 ACSS1/MPC2/TECR/DLD/PMVK/KYNU/SLC25A1 7 GO:0035383 thioester metabolic process 7/1165 96/18722 0.389244858819322 0.627825112802544 ACSS1/MPC2/TECR/DLD/PMVK/KYNU/SLC25A1 7 GO:0042472 inner ear morphogenesis 7/1165 96/18722 0.389244858819322 0.627825112802544 GATA3/ATP6V1B1/TFAP2A/SOD1/MYO7A/DLX5/TRIOBP 7 GO:0044264 cellular polysaccharide metabolic process 7/1165 96/18722 0.389244858819322 0.627825112802544 PHLDA2/SORBS1/AGL/IL6ST/IGF2/PHKB/UGP2 7 GO:0051304 chromosome separation 7/1165 96/18722 0.389244858819322 0.627825112802544 DUSP1/PLSCR1/ANAPC11/CENPF/RAD21/TOP2A/CCNB1 7 GO:1904035 regulation of epithelial cell apoptotic process 7/1165 96/18722 0.389244858819322 0.627825112802544 GATA3/YAP1/PDCD4/ZFP36/BAD/ZFP36L1/JAK2 7 GO:0002691 regulation of cellular extravasation 3/1165 36/18722 0.39008740957231 0.628281385919477 JAM3/ST3GAL4/ADAM8 3 GO:0010092 specification of animal organ identity 3/1165 36/18722 0.39008740957231 0.628281385919477 LRP2/ISL1/GLI3 3 GO:0036314 response to sterol 3/1165 36/18722 0.39008740957231 0.628281385919477 DAG1/TGFB1/PMVK 3 GO:0045191 regulation of isotype switching 3/1165 36/18722 0.39008740957231 0.628281385919477 TFRC/PTPRC/TGFB1 3 GO:0070873 regulation of glycogen metabolic process 3/1165 36/18722 0.39008740957231 0.628281385919477 PHLDA2/SORBS1/IGF2 3 GO:0001942 hair follicle development 6/1165 81/18722 0.391277254343908 0.62947527332541 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2 6 GO:0044773 mitotic DNA damage checkpoint signaling 6/1165 81/18722 0.391277254343908 0.62947527332541 FOXO4/PRKDC/SOX4/CCND1/MDM2/BABAM1 6 GO:0060968 regulation of gene silencing 6/1165 81/18722 0.391277254343908 0.62947527332541 EGFR/LIN28B/KCNQ1OT1/ZFP36/DNMT1/TGFB1 6 GO:2001021 negative regulation of response to DNA damage stimulus 6/1165 81/18722 0.391277254343908 0.62947527332541 CD44/MAGEF1/CD74/MDM2/USP47/RPS3 6 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 5/1165 66/18722 0.392675758599758 0.629775203675728 HSPD1/TFRC/PRKDC/PTPRC/TGFB1 5 GO:0016444 somatic cell DNA recombination 5/1165 66/18722 0.392675758599758 0.629775203675728 HSPD1/TFRC/PRKDC/PTPRC/TGFB1 5 GO:0019229 regulation of vasoconstriction 5/1165 66/18722 0.392675758599758 0.629775203675728 EGFR/GJA5/GJA1/ATP2B1/RHOA 5 GO:0042093 T-helper cell differentiation 5/1165 66/18722 0.392675758599758 0.629775203675728 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86 5 GO:0042446 hormone biosynthetic process 5/1165 66/18722 0.392675758599758 0.629775203675728 HSD17B1/AKR1B1/FDX1/HSD17B11/TSPO 5 GO:2000573 positive regulation of DNA biosynthetic process 5/1165 66/18722 0.392675758599758 0.629775203675728 PKIB/HSP90AB1/HSP90AA1/CCT2/KLF4 5 GO:0009948 anterior/posterior axis specification 4/1165 51/18722 0.392810081608538 0.629775203675728 WLS/GPC3/TBX3/BASP1 4 GO:0010874 regulation of cholesterol efflux 4/1165 51/18722 0.392810081608538 0.629775203675728 NFKBIA/APOE/TREM2/LRP1 4 GO:0051339 regulation of lyase activity 4/1165 51/18722 0.392810081608538 0.629775203675728 AKAP9/PARK7/GNAI2/ISCU 4 GO:0060043 regulation of cardiac muscle cell proliferation 4/1165 51/18722 0.392810081608538 0.629775203675728 TGFBR3/GJA1/YAP1/CCNB1 4 GO:0071622 regulation of granulocyte chemotaxis 4/1165 51/18722 0.392810081608538 0.629775203675728 DPP4/JAM3/C1QBP/CD74 4 GO:1903307 positive regulation of regulated secretory pathway 4/1165 51/18722 0.392810081608538 0.629775203675728 SYT7/HLA-F/FGR/SYK 4 GO:0048565 digestive tract development 9/1165 127/18722 0.393308080939413 0.630213604999407 EGFR/LGR4/GLI3/ASS1/YAP1/KLF5/IL6ST/TYMS/CCNB1 9 GO:0051224 negative regulation of protein transport 9/1165 127/18722 0.393308080939413 0.630213604999407 FERMT1/LMAN1/FRMD4A/NDFIP2/APOE/PARK7/RSAD2/ERP29/SNX3 9 GO:0046578 regulation of Ras protein signal transduction 13/1165 189/18722 0.395583115464761 0.633678089926856 ADGRG1/KANK1/MET/RASA1/NRP1/NET1/APOE/ITGB1/FBP1/EPS8/ARHGDIB/HRAS/STMN1 13 GO:0006721 terpenoid metabolic process 7/1165 97/18722 0.39959282657822 0.638169808312008 LRP2/EGFR/FDFT1/ADH5/AKR1B1/FDPS/LRP1 7 GO:0010596 negative regulation of endothelial cell migration 7/1165 97/18722 0.39959282657822 0.638169808312008 NR2F2/SERPINF1/APOE/RHOA/KLF4/ATP2B4/TGFB1 7 GO:0002053 positive regulation of mesenchymal cell proliferation 2/1165 22/18722 0.401570597355784 0.638169808312008 LRP5/STAT1 2 GO:0006359 regulation of transcription by RNA polymerase III 2/1165 22/18722 0.401570597355784 0.638169808312008 PRDX5/DHX36 2 GO:0006907 pinocytosis 2/1165 22/18722 0.401570597355784 0.638169808312008 PYCARD/CLN3 2 GO:0009220 pyrimidine ribonucleotide biosynthetic process 2/1165 22/18722 0.401570597355784 0.638169808312008 UPP1/NME1 2 GO:0010310 regulation of hydrogen peroxide metabolic process 2/1165 22/18722 0.401570597355784 0.638169808312008 SOD2/PRDX2 2 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/1165 22/18722 0.401570597355784 0.638169808312008 GSTO1/SLC8A1 2 GO:0014821 phasic smooth muscle contraction 2/1165 22/18722 0.401570597355784 0.638169808312008 TBX3/DLG1 2 GO:0021904 dorsal/ventral neural tube patterning 2/1165 22/18722 0.401570597355784 0.638169808312008 GLI3/PRKACB 2 GO:0032891 negative regulation of organic acid transport 2/1165 22/18722 0.401570597355784 0.638169808312008 ARL6IP5/FIS1 2 GO:0035089 establishment of apical/basal cell polarity 2/1165 22/18722 0.401570597355784 0.638169808312008 RHOA/MSN 2 GO:0035809 regulation of urine volume 2/1165 22/18722 0.401570597355784 0.638169808312008 AKR1B1/GNAI2 2 GO:0036120 cellular response to platelet-derived growth factor stimulus 2/1165 22/18722 0.401570597355784 0.638169808312008 YES1/PTN 2 GO:0042430 indole-containing compound metabolic process 2/1165 22/18722 0.401570597355784 0.638169808312008 IL4I1/KYNU 2 GO:0045540 regulation of cholesterol biosynthetic process 2/1165 22/18722 0.401570597355784 0.638169808312008 SOD1/APOE 2 GO:0045624 positive regulation of T-helper cell differentiation 2/1165 22/18722 0.401570597355784 0.638169808312008 PRKCZ/CD86 2 GO:0055093 response to hyperoxia 2/1165 22/18722 0.401570597355784 0.638169808312008 HDAC2/BNIP3 2 GO:0060444 branching involved in mammary gland duct morphogenesis 2/1165 22/18722 0.401570597355784 0.638169808312008 LRP5/TBX3 2 GO:0060563 neuroepithelial cell differentiation 2/1165 22/18722 0.401570597355784 0.638169808312008 CEBPB/SOX4 2 GO:0061042 vascular wound healing 2/1165 22/18722 0.401570597355784 0.638169808312008 CXCR4/VEGFA 2 GO:0071467 cellular response to pH 2/1165 22/18722 0.401570597355784 0.638169808312008 SLC9A1/GNA11 2 GO:0086012 membrane depolarization during cardiac muscle cell action potential 2/1165 22/18722 0.401570597355784 0.638169808312008 ANK3/SLC8A1 2 GO:0106118 regulation of sterol biosynthetic process 2/1165 22/18722 0.401570597355784 0.638169808312008 SOD1/APOE 2 GO:1900543 negative regulation of purine nucleotide metabolic process 2/1165 22/18722 0.401570597355784 0.638169808312008 PARP1/FBP1 2 GO:1901032 negative regulation of response to reactive oxygen species 2/1165 22/18722 0.401570597355784 0.638169808312008 MET/PARK7 2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 2/1165 22/18722 0.401570597355784 0.638169808312008 DLX5/VEGFA 2 GO:2000114 regulation of establishment of cell polarity 2/1165 22/18722 0.401570597355784 0.638169808312008 KANK1/GATA3 2 GO:0033865 nucleoside bisphosphate metabolic process 9/1165 128/18722 0.402305267657431 0.638794757386466 ACSS1/SLC26A2/TPST2/MPC2/TECR/DLD/PMVK/KYNU/SLC25A1 9 GO:0033875 ribonucleoside bisphosphate metabolic process 9/1165 128/18722 0.402305267657431 0.638794757386466 ACSS1/SLC26A2/TPST2/MPC2/TECR/DLD/PMVK/KYNU/SLC25A1 9 GO:0034032 purine nucleoside bisphosphate metabolic process 9/1165 128/18722 0.402305267657431 0.638794757386466 ACSS1/SLC26A2/TPST2/MPC2/TECR/DLD/PMVK/KYNU/SLC25A1 9 GO:0016575 histone deacetylation 6/1165 82/18722 0.402571327052718 0.638855770072635 TBL1X/VEGFA/MORF4L2/HDAC2/MORF4L1/PHB 6 GO:0043242 negative regulation of protein-containing complex disassembly 6/1165 82/18722 0.402571327052718 0.638855770072635 SCIN/LIMA1/EPS8/CIB1/TRIOBP/ADD3 6 GO:0051216 cartilage development 13/1165 190/18722 0.402954223162558 0.639282660998145 EFEMP1/BMP7/SERPINH1/TIMP1/CD44/GLI3/SCIN/ITGB8/ESRRA/TGFB1/TYMS/CREB3L2/SULF2 13 GO:0009880 embryonic pattern specification 5/1165 67/18722 0.405221635455254 0.642153879110767 BMP7/NRP2/TBX3/NRP1/BASP1 5 GO:0032890 regulation of organic acid transport 5/1165 67/18722 0.405221635455254 0.642153879110767 PTGES/ITGB1/ARL6IP5/FIS1/SYK 5 GO:0035914 skeletal muscle cell differentiation 5/1165 67/18722 0.405221635455254 0.642153879110767 GPC1/KLF5/FOS/UQCC2/NR4A1 5 GO:0051306 mitotic sister chromatid separation 5/1165 67/18722 0.405221635455254 0.642153879110767 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0044344 cellular response to fibroblast growth factor stimulus 8/1165 113/18722 0.406077451646805 0.642551271936395 GATA3/CD44/GPC1/ZFP36/GCLM/ZFP36L1/SULF2/NR4A1 8 GO:0051496 positive regulation of stress fiber assembly 4/1165 52/18722 0.40712562560112 0.642551271936395 FERMT2/S100A10/NRP1/RHOA 4 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 4/1165 52/18722 0.40712562560112 0.642551271936395 ZNRF3/GPC3/DAB2/RHOA 4 GO:0072132 mesenchyme morphogenesis 4/1165 52/18722 0.40712562560112 0.642551271936395 BMP7/ISL1/TBX3/MDM2 4 GO:0072523 purine-containing compound catabolic process 4/1165 52/18722 0.40712562560112 0.642551271936395 HINT1/NUDT4/DNPH1/PNP 4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3/1165 37/18722 0.407189537551712 0.642551271936395 RPS21/RPS14/RPS16 3 GO:0006623 protein targeting to vacuole 3/1165 37/18722 0.407189537551712 0.642551271936395 LAPTM5/HSPA8/SORL1 3 GO:0016202 regulation of striated muscle tissue development 3/1165 37/18722 0.407189537551712 0.642551271936395 TGFB1/CENPF/IGF2 3 GO:0033260 nuclear DNA replication 3/1165 37/18722 0.407189537551712 0.642551271936395 MCM3/MCM6/GMNN 3 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 3/1165 37/18722 0.407189537551712 0.642551271936395 GATA3/GPC1/SULF2 3 GO:0043368 positive T cell selection 3/1165 37/18722 0.407189537551712 0.642551271936395 CTSL/PTPRC/CD74 3 GO:0045616 regulation of keratinocyte differentiation 3/1165 37/18722 0.407189537551712 0.642551271936395 ZFP36/NCOA3/ZFP36L1 3 GO:0071985 multivesicular body sorting pathway 3/1165 37/18722 0.407189537551712 0.642551271936395 EXPH5/VCP/VPS25 3 GO:1900077 negative regulation of cellular response to insulin stimulus 3/1165 37/18722 0.407189537551712 0.642551271936395 KANK1/PRKCZ/SOCS3 3 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 3/1165 37/18722 0.407189537551712 0.642551271936395 PKIB/CCT2/DHX36 3 GO:0003333 amino acid transmembrane transport 7/1165 98/18722 0.409937277600233 0.646705435404752 SLC38A1/SLC38A9/ITGB1/ARL6IP5/SLC1A3/SLC25A13/SLC7A7 7 GO:0007093 mitotic cell cycle checkpoint signaling 9/1165 129/18722 0.411305615697375 0.64868177041567 DUSP1/FOXO4/PRKDC/SOX4/CCND1/MDM2/CENPF/BABAM1/CCNB1 9 GO:0048562 embryonic organ morphogenesis 19/1165 285/18722 0.411832470111741 0.64933024009472 FBN1/FBN2/EFEMP1/BMP7/FOLR1/GATA3/ATP6V1B1/TFAP2A/GLI3/SOD1/TBX3/EFNA1/YAP1/MYO7A/MFAP5/DLG1/DLX5/SLC39A1/TRIOBP 19 GO:0008645 hexose transmembrane transport 8/1165 114/18722 0.415678548696499 0.655026303715174 SLC2A1/SORBS1/GPC3/SLC5A3/YES1/SLC2A3/OPN3/PEA15 8 GO:1904892 regulation of receptor signaling pathway via STAT 8/1165 114/18722 0.415678548696499 0.655026303715174 PRLR/AKR1B1/PTPRC/TGFB1/SOCS3/IL10RB/CD300A/JAK2 8 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 5/1165 68/18722 0.417734420013904 0.657896548691931 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86 5 GO:1904888 cranial skeletal system development 5/1165 68/18722 0.417734420013904 0.657896548691931 TFAP2A/GLI3/MSX2/IRF6/SLC39A1 5 GO:0015918 sterol transport 9/1165 130/18722 0.420304443511652 0.659297589388011 SYT7/LIMA1/NFKBIA/APOE/APOC1/OSBPL9/TREM2/TSPO/LRP1 9 GO:0016925 protein sumoylation 4/1165 53/18722 0.421372911662836 0.659297589388011 CBX4/GNL3/MDM2/PARK7 4 GO:0033059 cellular pigmentation 4/1165 53/18722 0.421372911662836 0.659297589388011 MYO7A/TRAPPC6A/RAB11A/ZEB2 4 GO:0043113 receptor clustering 4/1165 53/18722 0.421372911662836 0.659297589388011 APOE/PTN/DLG1/FLNA 4 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 4/1165 53/18722 0.421372911662836 0.659297589388011 MET/ATP2B4/STMN1/GNAI2 4 GO:0071466 cellular response to xenobiotic stimulus 12/1165 177/18722 0.422394859349544 0.659297589388011 EGFR/CXCR4/TFRC/APOBEC3A/FBP1/GSTA4/HSPA5/GSTP1/MCM7/GSTO1/S100A12/NME1 12 GO:0002363 alpha-beta T cell lineage commitment 2/1165 23/18722 0.423687845837015 0.659297589388011 CTSL/RHOA 2 GO:0003323 type B pancreatic cell development 2/1165 23/18722 0.423687845837015 0.659297589388011 CDK6/BAD 2 GO:0010888 negative regulation of lipid storage 2/1165 23/18722 0.423687845837015 0.659297589388011 NFKBIA/TREM2 2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 2/1165 23/18722 0.423687845837015 0.659297589388011 CLDN4/CLDN7 2 GO:0021871 forebrain regionalization 2/1165 23/18722 0.423687845837015 0.659297589388011 ADGRG1/GLI3 2 GO:0030194 positive regulation of blood coagulation 2/1165 23/18722 0.423687845837015 0.659297589388011 PRDX2/ST3GAL4 2 GO:0031280 negative regulation of cyclase activity 2/1165 23/18722 0.423687845837015 0.659297589388011 AKAP9/GNAI2 2 GO:0032740 positive regulation of interleukin-17 production 2/1165 23/18722 0.423687845837015 0.659297589388011 TGFB1/PHB 2 GO:0033081 regulation of T cell differentiation in thymus 2/1165 23/18722 0.423687845837015 0.659297589388011 SOD1/ADAM8 2 GO:0035640 exploration behavior 2/1165 23/18722 0.423687845837015 0.659297589388011 DPP4/APOE 2 GO:0036119 response to platelet-derived growth factor 2/1165 23/18722 0.423687845837015 0.659297589388011 YES1/PTN 2 GO:0042438 melanin biosynthetic process 2/1165 23/18722 0.423687845837015 0.659297589388011 OPN3/ZEB2 2 GO:0043931 ossification involved in bone maturation 2/1165 23/18722 0.423687845837015 0.659297589388011 SNX10/RHOA 2 GO:0045980 negative regulation of nucleotide metabolic process 2/1165 23/18722 0.423687845837015 0.659297589388011 PARP1/FBP1 2 GO:0051349 positive regulation of lyase activity 2/1165 23/18722 0.423687845837015 0.659297589388011 PARK7/ISCU 2 GO:0051904 pigment granule transport 2/1165 23/18722 0.423687845837015 0.659297589388011 MYO7A/RAB11A 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/1165 23/18722 0.423687845837015 0.659297589388011 GJA5/AKAP9 2 GO:0060487 lung epithelial cell differentiation 2/1165 23/18722 0.423687845837015 0.659297589388011 YAP1/KLF2 2 GO:0071305 cellular response to vitamin D 2/1165 23/18722 0.423687845837015 0.659297589388011 PTN/ATP2B1 2 GO:0071514 genetic imprinting 2/1165 23/18722 0.423687845837015 0.659297589388011 DNMT3A/IGF2 2 GO:0071636 positive regulation of transforming growth factor beta production 2/1165 23/18722 0.423687845837015 0.659297589388011 FERMT1/CD46 2 GO:1900048 positive regulation of hemostasis 2/1165 23/18722 0.423687845837015 0.659297589388011 PRDX2/ST3GAL4 2 GO:2000810 regulation of bicellular tight junction assembly 2/1165 23/18722 0.423687845837015 0.659297589388011 GJA1/TJP1 2 GO:0140014 mitotic nuclear division 19/1165 287/18722 0.423937101263746 0.659297589388011 BMP7/LRP5/OBSL1/DUSP1/RHOA/AURKAIP1/FLNA/EPS8/RAN/ANAPC11/RANBP1/MKI67/CENPF/IGF2/NAA10/RAD21/RAB11A/SMC3/CCNB1 19 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 10/1165 146/18722 0.424126196612456 0.659297589388011 ADGRG1/LGR5/LGR4/ADRB1/GNAS/ATP2B4/GNAI2/CXCL10/S1PR4/ADGRE5 10 GO:0010675 regulation of cellular carbohydrate metabolic process 10/1165 146/18722 0.424126196612456 0.659297589388011 PHLDA2/SORBS1/SLC35B4/DDB1/FBP1/PMAIP1/PGP/IGF2/BAD/FAM3C 10 GO:0048813 dendrite morphogenesis 10/1165 146/18722 0.424126196612456 0.659297589388011 OBSL1/EFNA1/NRP1/ITGB1/PTN/ID1/DHX36/WASL/DOCK10/ABI3 10 GO:0006882 cellular zinc ion homeostasis 3/1165 38/18722 0.424144592068432 0.659297589388011 SLC39A10/S100A8/SLC39A7 3 GO:0007094 mitotic spindle assembly checkpoint signaling 3/1165 38/18722 0.424144592068432 0.659297589388011 DUSP1/CENPF/CCNB1 3 GO:0008210 estrogen metabolic process 3/1165 38/18722 0.424144592068432 0.659297589388011 HSD17B1/COMT/HSD17B11 3 GO:0010613 positive regulation of cardiac muscle hypertrophy 3/1165 38/18722 0.424144592068432 0.659297589388011 PARP1/SLC9A1/IL6ST 3 GO:0010742 macrophage derived foam cell differentiation 3/1165 38/18722 0.424144592068432 0.659297589388011 NFKBIA/STAT1/TGFB1 3 GO:0032941 secretion by tissue 3/1165 38/18722 0.424144592068432 0.659297589388011 EGFR/CYBA/KCNN4 3 GO:0046329 negative regulation of JNK cascade 3/1165 38/18722 0.424144592068432 0.659297589388011 MARVELD3/PDCD4/GSTP1 3 GO:0051930 regulation of sensory perception of pain 3/1165 38/18722 0.424144592068432 0.659297589388011 SLC9A1/MGLL/COMT 3 GO:0071173 spindle assembly checkpoint signaling 3/1165 38/18722 0.424144592068432 0.659297589388011 DUSP1/CENPF/CCNB1 3 GO:0071174 mitotic spindle checkpoint signaling 3/1165 38/18722 0.424144592068432 0.659297589388011 DUSP1/CENPF/CCNB1 3 GO:0071392 cellular response to estradiol stimulus 3/1165 38/18722 0.424144592068432 0.659297589388011 EGFR/FAM210B/NCOA3 3 GO:0071398 cellular response to fatty acid 3/1165 38/18722 0.424144592068432 0.659297589388011 ASS1/NME1/CCNB1 3 GO:0090077 foam cell differentiation 3/1165 38/18722 0.424144592068432 0.659297589388011 NFKBIA/STAT1/TGFB1 3 GO:1903725 regulation of phospholipid metabolic process 3/1165 38/18722 0.424144592068432 0.659297589388011 IDH1/APOC1/STOML2 3 GO:0010660 regulation of muscle cell apoptotic process 6/1165 84/18722 0.425107255430767 0.659880261264628 BMP7/SOD2/PDCD4/DNMT1/BNIP3/JAK2 6 GO:0015844 monoamine transport 6/1165 84/18722 0.425107255430767 0.659880261264628 SLC6A4/SYT7/PARK7/LILRB1/ACTB/SYK 6 GO:0022404 molting cycle process 6/1165 84/18722 0.425107255430767 0.659880261264628 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2 6 GO:0022405 hair cycle process 6/1165 84/18722 0.425107255430767 0.659880261264628 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2 6 GO:0042440 pigment metabolic process 6/1165 84/18722 0.425107255430767 0.659880261264628 PAICS/OPN3/SLCO2B1/TSPO/UROD/ZEB2 6 GO:0051209 release of sequestered calcium ion into cytosol 8/1165 115/18722 0.425271727836624 0.659953057325677 CYBA/PTPRC/PTPN6/GSTO1/ERO1A/CXCL10/SLC8A1/LYN 8 GO:0007204 positive regulation of cytosolic calcium ion concentration 21/1165 319/18722 0.426965527585633 0.662398426295787 GJA1/CXCR4/CYBA/CD24/TGM2/PTPRC/CD55/ATP2B4/PTPN6/CD52/GSTO1/FPR1/FPR3/ERO1A/CXCL10/S1PR4/FIS1/SLC8A1/LRP1/JAK2/LYN 21 GO:0006869 lipid transport 26/1165 398/18722 0.427581682934445 0.663171037941708 SLC27A2/SLC2A1/SYT7/PTGES/LIMA1/KCNN4/DBI/NFKBIA/APOE/ATP10D/STARD10/PLSCR1/APOC1/PLIN2/OSBPL9/SLCO2B1/TREM2/RETN/FIS1/CLN3/TSPO/APOL6/SYK/LRP1/AQP9/APOBR 26 GO:0006612 protein targeting to membrane 9/1165 131/18722 0.429297145744794 0.665463926833893 TCAF1/ANK3/NCF1/HSPA5/SIL1/CIB1/SRP14/HRAS/FIS1 9 GO:1904950 negative regulation of establishment of protein localization 9/1165 131/18722 0.429297145744794 0.665463926833893 FERMT1/LMAN1/FRMD4A/NDFIP2/APOE/PARK7/RSAD2/ERP29/SNX3 9 GO:0035265 organ growth 12/1165 178/18722 0.430101733642465 0.665580680589047 TGFBR3/SLC6A4/GJA1/DUSP9/SOD1/YAP1/LATS2/SERP1/BASP1/IGF2/CGA/CCNB1 12 GO:0002287 alpha-beta T cell activation involved in immune response 5/1165 69/18722 0.43020251366062 0.665580680589047 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86 5 GO:0002293 alpha-beta T cell differentiation involved in immune response 5/1165 69/18722 0.43020251366062 0.665580680589047 GATA3/PRKCZ/HLA-DRA/HLA-DRB1/CD86 5 GO:0010611 regulation of cardiac muscle hypertrophy 5/1165 69/18722 0.43020251366062 0.665580680589047 PARP1/SLC9A1/ATP2B4/IL6ST/TNFRSF1B 5 GO:0033344 cholesterol efflux 5/1165 69/18722 0.43020251366062 0.665580680589047 NFKBIA/APOE/APOC1/TREM2/LRP1 5 GO:0050805 negative regulation of synaptic transmission 5/1165 69/18722 0.43020251366062 0.665580680589047 SLC6A4/GNAI1/PNKD/LILRB2/GNAI2 5 GO:0050810 regulation of steroid biosynthetic process 5/1165 69/18722 0.43020251366062 0.665580680589047 SOD1/APOE/SF1/TSPO/CGA 5 GO:0006641 triglyceride metabolic process 7/1165 100/18722 0.430587842378923 0.665809795942946 MGLL/APOE/GPX1/APOC1/SORL1/GK/APOBR 7 GO:0019218 regulation of steroid metabolic process 7/1165 100/18722 0.430587842378923 0.665809795942946 SOD1/APOE/APOC1/SF1/TSPO/CGA/ACADVL 7 GO:0060041 retina development in camera-type eye 10/1165 147/18722 0.432619434481334 0.668766974867454 LRP5/SERPINF1/TFAP2A/OBSL1/NRP1/PTN/ATP2B1/PFDN5/ATP2B4/IMPDH2 10 GO:0006720 isoprenoid metabolic process 8/1165 116/18722 0.434851511748814 0.671662502874545 LRP2/EGFR/FDFT1/ADH5/AKR1B1/FDPS/PMVK/LRP1 8 GO:0015749 monosaccharide transmembrane transport 8/1165 116/18722 0.434851511748814 0.671662502874545 SLC2A1/SORBS1/GPC3/SLC5A3/YES1/SLC2A3/OPN3/PEA15 8 GO:0051283 negative regulation of sequestering of calcium ion 8/1165 116/18722 0.434851511748814 0.671662502874545 CYBA/PTPRC/PTPN6/GSTO1/ERO1A/CXCL10/SLC8A1/LYN 8 GO:1902743 regulation of lamellipodium organization 4/1165 54/18722 0.435535854157379 0.672534456502164 KANK1/CD44/WASF2/ABI3 4 GO:0044774 mitotic DNA integrity checkpoint signaling 6/1165 85/18722 0.436331725616094 0.673022801836531 FOXO4/PRKDC/SOX4/CCND1/MDM2/BABAM1 6 GO:0055013 cardiac muscle cell development 6/1165 85/18722 0.436331725616094 0.673022801836531 ISL1/OBSL1/TBX3/VEGFA/SLC8A1/CCNB1 6 GO:0071277 cellular response to calcium ion 6/1165 85/18722 0.436331725616094 0.673022801836531 SYT7/LGMN/HSPA5/FOS/FUS/JUNB 6 GO:0098773 skin epidermis development 6/1165 85/18722 0.436331725616094 0.673022801836531 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2 6 GO:0010876 lipid localization 29/1165 448/18722 0.44024408427435 0.678063531706293 SLC27A2/SLC2A1/MEST/SYT7/PTGES/HILPDA/LIMA1/KCNN4/DBI/NFKBIA/APOE/ATP10D/STARD10/PLSCR1/APOC1/PLIN2/OSBPL9/STOML2/SLCO2B1/TREM2/RETN/FIS1/CLN3/TSPO/APOL6/SYK/LRP1/AQP9/APOBR 29 GO:0007618 mating 3/1165 39/18722 0.440928539235341 0.678063531706293 SLC6A4/APP/HDAC2 3 GO:0014742 positive regulation of muscle hypertrophy 3/1165 39/18722 0.440928539235341 0.678063531706293 PARP1/SLC9A1/IL6ST 3 GO:0016233 telomere capping 3/1165 39/18722 0.440928539235341 0.678063531706293 PKIB/PRKDC/RAD50 3 GO:0031577 spindle checkpoint signaling 3/1165 39/18722 0.440928539235341 0.678063531706293 DUSP1/CENPF/CCNB1 3 GO:0046326 positive regulation of glucose import 3/1165 39/18722 0.440928539235341 0.678063531706293 SORBS1/GPC3/OPN3 3 GO:0046621 negative regulation of organ growth 3/1165 39/18722 0.440928539235341 0.678063531706293 SLC6A4/GJA1/CGA 3 GO:0051931 regulation of sensory perception 3/1165 39/18722 0.440928539235341 0.678063531706293 SLC9A1/MGLL/COMT 3 GO:0071548 response to dexamethasone 3/1165 39/18722 0.440928539235341 0.678063531706293 EGFR/SERPINF1/ASS1 3 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 3/1165 39/18722 0.440928539235341 0.678063531706293 SLC9A1/GSTO1/VMP1 3 GO:1901861 regulation of muscle tissue development 3/1165 39/18722 0.440928539235341 0.678063531706293 TGFB1/CENPF/IGF2 3 GO:0003407 neural retina development 5/1165 70/18722 0.442614788847684 0.680052963951895 TFAP2A/OBSL1/PTN/ATP2B1/ATP2B4 5 GO:0045123 cellular extravasation 5/1165 70/18722 0.442614788847684 0.680052963951895 JAM3/ITGB1/PECAM1/ST3GAL4/ADAM8 5 GO:0060415 muscle tissue morphogenesis 5/1165 70/18722 0.442614788847684 0.680052963951895 LRP2/TGFBR3/DSP/ISL1/TGFB1 5 GO:0030301 cholesterol transport 8/1165 117/18722 0.444412542835819 0.680052963951895 SYT7/LIMA1/NFKBIA/APOE/APOC1/TREM2/TSPO/LRP1 8 GO:0001702 gastrulation with mouth forming second 2/1165 24/18722 0.445372295650662 0.680052963951895 LRP5/AMOT 2 GO:0001779 natural killer cell differentiation 2/1165 24/18722 0.445372295650662 0.680052963951895 PBX1/PTPRC 2 GO:0006582 melanin metabolic process 2/1165 24/18722 0.445372295650662 0.680052963951895 OPN3/ZEB2 2 GO:0006817 phosphate ion transport 2/1165 24/18722 0.445372295650662 0.680052963951895 SLC25A3/CEBPB 2 GO:0010226 response to lithium ion 2/1165 24/18722 0.445372295650662 0.680052963951895 CDH1/CALR 2 GO:0016048 detection of temperature stimulus 2/1165 24/18722 0.445372295650662 0.680052963951895 CXCR4/NR2F6 2 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 2/1165 24/18722 0.445372295650662 0.680052963951895 C1QBP/OASL 2 GO:0044062 regulation of excretion 2/1165 24/18722 0.445372295650662 0.680052963951895 COMT/GNAI2 2 GO:0044321 response to leptin 2/1165 24/18722 0.445372295650662 0.680052963951895 LRP2/CCND1 2 GO:0045649 regulation of macrophage differentiation 2/1165 24/18722 0.445372295650662 0.680052963951895 C1QC/TGFB1 2 GO:0048641 regulation of skeletal muscle tissue development 2/1165 24/18722 0.445372295650662 0.680052963951895 TGFB1/IGF2 2 GO:0050820 positive regulation of coagulation 2/1165 24/18722 0.445372295650662 0.680052963951895 PRDX2/ST3GAL4 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/1165 24/18722 0.445372295650662 0.680052963951895 APOE/GCH1 2 GO:0051123 RNA polymerase II preinitiation complex assembly 2/1165 24/18722 0.445372295650662 0.680052963951895 TAF11/PSMC6 2 GO:0051647 nucleus localization 2/1165 24/18722 0.445372295650662 0.680052963951895 SYNE2/PCM1 2 GO:0051905 establishment of pigment granule localization 2/1165 24/18722 0.445372295650662 0.680052963951895 MYO7A/RAB11A 2 GO:0060479 lung cell differentiation 2/1165 24/18722 0.445372295650662 0.680052963951895 YAP1/KLF2 2 GO:0061162 establishment of monopolar cell polarity 2/1165 24/18722 0.445372295650662 0.680052963951895 RHOA/MSN 2 GO:0071294 cellular response to zinc ion 2/1165 24/18722 0.445372295650662 0.680052963951895 PARP1/TSPO 2 GO:0071676 negative regulation of mononuclear cell migration 2/1165 24/18722 0.445372295650662 0.680052963951895 DUSP1/WASL 2 GO:0090023 positive regulation of neutrophil chemotaxis 2/1165 24/18722 0.445372295650662 0.680052963951895 C1QBP/CD74 2 GO:2000310 regulation of NMDA receptor activity 2/1165 24/18722 0.445372295650662 0.680052963951895 APP/IFNGR2 2 GO:0060761 negative regulation of response to cytokine stimulus 6/1165 86/18722 0.447516069690669 0.6829547849847 ISG15/PTPRC/GSTP1/KLF4/TREM2/OAS1 6 GO:1903510 mucopolysaccharide metabolic process 6/1165 86/18722 0.447516069690669 0.6829547849847 ITIH5/CHPF/CD44/CLTC/TGFB1/ST3GAL4 6 GO:0006360 transcription by RNA polymerase I 4/1165 55/18722 0.44959927636 0.685016487027329 POLR2L/FLNA/POLR2K/NCL 4 GO:0010676 positive regulation of cellular carbohydrate metabolic process 4/1165 55/18722 0.44959927636 0.685016487027329 SORBS1/DDB1/PMAIP1/IGF2 4 GO:0046164 alcohol catabolic process 4/1165 55/18722 0.44959927636 0.685016487027329 APOE/TPI1/ALDH2/GK 4 GO:0048016 inositol phosphate-mediated signaling 4/1165 55/18722 0.44959927636 0.685016487027329 SLC9A1/ATP2B4/CIB1/NFAT5 4 GO:0061098 positive regulation of protein tyrosine kinase activity 4/1165 55/18722 0.44959927636 0.685016487027329 ERBB3/CD24/EFNA1/NCF1 4 GO:1902991 regulation of amyloid precursor protein catabolic process 4/1165 55/18722 0.44959927636 0.685016487027329 EFNA1/APOE/SORL1/LYN 4 GO:0034219 carbohydrate transmembrane transport 8/1165 118/18722 0.453949589004985 0.691269409409924 SLC2A1/SORBS1/GPC3/SLC5A3/YES1/SLC2A3/OPN3/PEA15 8 GO:0051282 regulation of sequestering of calcium ion 8/1165 118/18722 0.453949589004985 0.691269409409924 CYBA/PTPRC/PTPN6/GSTO1/ERO1A/CXCL10/SLC8A1/LYN 8 GO:0044275 cellular carbohydrate catabolic process 3/1165 40/18722 0.45751941313884 0.693166819520011 AGL/TPI1/GK 3 GO:0055069 zinc ion homeostasis 3/1165 40/18722 0.45751941313884 0.693166819520011 SLC39A10/S100A8/SLC39A7 3 GO:0060412 ventricular septum morphogenesis 3/1165 40/18722 0.45751941313884 0.693166819520011 TGFBR3/TBX3/SOX4 3 GO:0072210 metanephric nephron development 3/1165 40/18722 0.45751941313884 0.693166819520011 LGR4/IRX2/STAT1 3 GO:0097352 autophagosome maturation 3/1165 40/18722 0.45751941313884 0.693166819520011 VCP/VMP1/CLN3 3 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 3/1165 40/18722 0.45751941313884 0.693166819520011 C4orf3/GSTO1/YWHAE 3 GO:1901223 negative regulation of NIK/NF-kappaB signaling 3/1165 40/18722 0.45751941313884 0.693166819520011 BMP7/TMSB4X/SPI1 3 GO:0019915 lipid storage 6/1165 87/18722 0.458652298256418 0.693166819520011 MEST/HILPDA/NFKBIA/APOE/PLIN2/TREM2 6 GO:0051260 protein homooligomerization 12/1165 182/18722 0.460869731950685 0.693166819520011 B2M/SOD2/ALDOA/KCNG1/FUS/PYCARD/GBP5/RNF213/VASP/SSBP1/KCTD12/PRMT1 12 GO:0019233 sensory perception of pain 7/1165 103/18722 0.461368169826615 0.693166819520011 MME/CXCR4/PTGES/NR2F6/SLC9A1/MGLL/COMT 7 GO:0030004 cellular monovalent inorganic cation homeostasis 7/1165 103/18722 0.461368169826615 0.693166819520011 SLC9A1/SLC11A1/SLC1A3/TMEM165/CLN3/SLC8A1/GRN 7 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 7/1165 103/18722 0.461368169826615 0.693166819520011 PRLR/AKR1B1/PTPRC/SOCS3/IL10RB/CD300A/JAK2 7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/1165 56/18722 0.463548908577437 0.693166819520011 ZFP36/DHX36/PABPC1/ZFP36L1 4 GO:0042733 embryonic digit morphogenesis 4/1165 56/18722 0.463548908577437 0.693166819520011 LRP5/GLI3/TBX3/HDAC2 4 GO:0045599 negative regulation of fat cell differentiation 4/1165 56/18722 0.463548908577437 0.693166819520011 GATA3/FERMT2/YAP1/TGFB1 4 GO:0046456 icosanoid biosynthetic process 4/1165 56/18722 0.463548908577437 0.693166819520011 MGST3/PTGES/CD74/SYK 4 GO:0051653 spindle localization 4/1165 56/18722 0.463548908577437 0.693166819520011 GJA1/ASPM/ITGB1/WASL 4 GO:0090175 regulation of establishment of planar polarity 4/1165 56/18722 0.463548908577437 0.693166819520011 ZNRF3/GPC3/DAB2/RHOA 4 GO:0006261 DNA-dependent DNA replication 10/1165 151/18722 0.466468703945061 0.693166819520011 MCM3/MCM6/CCNE1/MCM7/ORC6/NUCKS1/STOML2/RFC1/SSBP1/GMNN 10 GO:0055067 monovalent inorganic cation homeostasis 10/1165 151/18722 0.466468703945061 0.693166819520011 ATP6V1B1/SLC9A1/COMT/SLC11A1/SLC1A3/GNAI2/TMEM165/CLN3/SLC8A1/GRN 10 GO:0006658 phosphatidylserine metabolic process 2/1165 25/18722 0.466592151435225 0.693166819520011 SERINC2/PLSCR1 2 GO:0010842 retina layer formation 2/1165 25/18722 0.466592151435225 0.693166819520011 TFAP2A/OBSL1 2 GO:0021846 cell proliferation in forebrain 2/1165 25/18722 0.466592151435225 0.693166819520011 GLI3/PCM1 2 GO:0032878 regulation of establishment or maintenance of cell polarity 2/1165 25/18722 0.466592151435225 0.693166819520011 KANK1/GATA3 2 GO:0033119 negative regulation of RNA splicing 2/1165 25/18722 0.466592151435225 0.693166819520011 NPM1/C1QBP 2 GO:0033233 regulation of protein sumoylation 2/1165 25/18722 0.466592151435225 0.693166819520011 GNL3/PARK7 2 GO:0044550 secondary metabolite biosynthetic process 2/1165 25/18722 0.466592151435225 0.693166819520011 OPN3/ZEB2 2 GO:0045109 intermediate filament organization 2/1165 25/18722 0.466592151435225 0.693166819520011 DSP/VIM 2 GO:0046949 fatty-acyl-CoA biosynthetic process 2/1165 25/18722 0.466592151435225 0.693166819520011 TECR/SLC25A1 2 GO:0048596 embryonic camera-type eye morphogenesis 2/1165 25/18722 0.466592151435225 0.693166819520011 BMP7/TFAP2A 2 GO:0050951 sensory perception of temperature stimulus 2/1165 25/18722 0.466592151435225 0.693166819520011 CXCR4/NR2F6 2 GO:0050995 negative regulation of lipid catabolic process 2/1165 25/18722 0.466592151435225 0.693166819520011 APOC1/SORL1 2 GO:0051450 myoblast proliferation 2/1165 25/18722 0.466592151435225 0.693166819520011 GPX1/MALAT1 2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 2/1165 25/18722 0.466592151435225 0.693166819520011 DHX36/PSMC6 2 GO:0061339 establishment or maintenance of monopolar cell polarity 2/1165 25/18722 0.466592151435225 0.693166819520011 RHOA/MSN 2 GO:0062149 detection of stimulus involved in sensory perception of pain 2/1165 25/18722 0.466592151435225 0.693166819520011 CXCR4/NR2F6 2 GO:0072012 glomerulus vasculature development 2/1165 25/18722 0.466592151435225 0.693166819520011 BMP7/PECAM1 2 GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/1165 25/18722 0.466592151435225 0.693166819520011 FLNA/YWHAE 2 GO:0098703 calcium ion import across plasma membrane 2/1165 25/18722 0.466592151435225 0.693166819520011 ATP2B4/SLC8A1 2 GO:1901623 regulation of lymphocyte chemotaxis 2/1165 25/18722 0.466592151435225 0.693166819520011 CXCL10/CCL4 2 GO:1902993 positive regulation of amyloid precursor protein catabolic process 2/1165 25/18722 0.466592151435225 0.693166819520011 EFNA1/LYN 2 GO:1903055 positive regulation of extracellular matrix organization 2/1165 25/18722 0.466592151435225 0.693166819520011 DAG1/TGFB1 2 GO:1903792 negative regulation of anion transport 2/1165 25/18722 0.466592151435225 0.693166819520011 GABRE/ARL6IP5 2 GO:0014743 regulation of muscle hypertrophy 5/1165 72/18722 0.467229780555411 0.693166819520011 PARP1/SLC9A1/ATP2B4/IL6ST/TNFRSF1B 5 GO:0033045 regulation of sister chromatid segregation 5/1165 72/18722 0.467229780555411 0.693166819520011 DUSP1/ANAPC11/CENPF/RAD21/CCNB1 5 GO:0035567 non-canonical Wnt signaling pathway 5/1165 72/18722 0.467229780555411 0.693166819520011 ZNRF3/GPC3/DAB2/RHOA/RNF213 5 GO:0031110 regulation of microtubule polymerization or depolymerization 6/1165 88/18722 0.469732717050131 0.693166819520011 MET/CLIP1/AKAP9/CIB1/STMN1/RPS3 6 GO:0050779 RNA destabilization 6/1165 88/18722 0.469732717050131 0.693166819520011 LIN28B/ZFP36/DHX36/PABPC1/ZFP36L1/TNFRSF1B 6 GO:0070098 chemokine-mediated signaling pathway 6/1165 88/18722 0.469732717050131 0.693166819520011 CXCR4/CCL3L3/CIB1/TREM2/CXCL10/CCL4 6 GO:0014896 muscle hypertrophy 7/1165 104/18722 0.471550848695231 0.693166819520011 PARP1/CYBA/SLC9A1/ATP2B4/IL6ST/HDAC2/TNFRSF1B 7 GO:0071774 response to fibroblast growth factor 8/1165 120/18722 0.472931456992337 0.693166819520011 GATA3/CD44/GPC1/ZFP36/GCLM/ZFP36L1/SULF2/NR4A1 8 GO:0031062 positive regulation of histone methylation 3/1165 41/18722 0.473897244363339 0.693166819520011 BRD4/DNMT1/RTF1 3 GO:0044786 cell cycle DNA replication 3/1165 41/18722 0.473897244363339 0.693166819520011 MCM3/MCM6/GMNN 3 GO:0048634 regulation of muscle organ development 3/1165 41/18722 0.473897244363339 0.693166819520011 TGFB1/CENPF/IGF2 3 GO:0055023 positive regulation of cardiac muscle tissue growth 3/1165 41/18722 0.473897244363339 0.693166819520011 TGFBR3/YAP1/CCNB1 3 GO:0043624 cellular protein complex disassembly 9/1165 136/18722 0.47401354687618 0.693166819520011 SCIN/DSTN/LIMA1/EPS8/CIB1/TRIOBP/STMN1/ADD3/HSPA8 9 GO:1903305 regulation of regulated secretory pathway 9/1165 136/18722 0.47401354687618 0.693166819520011 SYT7/STXBP2/HLA-F/SPI1/FGR/GNAI2/SYK/CD300A/LYN 9 GO:0000050 urea cycle 1/1165 10/18722 0.474090044563927 0.693166819520011 ASS1 1 GO:0000098 sulfur amino acid catabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 CDO1 1 GO:0001553 luteinization 1/1165 10/18722 0.474090044563927 0.693166819520011 RETN 1 GO:0001672 regulation of chromatin assembly or disassembly 1/1165 10/18722 0.474090044563927 0.693166819520011 TLK1 1 GO:0003330 regulation of extracellular matrix constituent secretion 1/1165 10/18722 0.474090044563927 0.693166819520011 TNFRSF1B 1 GO:0005984 disaccharide metabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 FBP1 1 GO:0006222 UMP biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 UPP1 1 GO:0006228 UTP biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 NME1 1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1/1165 10/18722 0.474090044563927 0.693166819520011 DDX1 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 PISD 1 GO:0006735 NADH regeneration 1/1165 10/18722 0.474090044563927 0.693166819520011 ENO1 1 GO:0007028 cytoplasm organization 1/1165 10/18722 0.474090044563927 0.693166819520011 TFCP2L1 1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 GNAS 1 GO:0009113 purine nucleobase biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 PAICS 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 AK3 1 GO:0009169 purine ribonucleoside monophosphate catabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 PNP 1 GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 UPP1 1 GO:0009750 response to fructose 1/1165 10/18722 0.474090044563927 0.693166819520011 KRT18 1 GO:0010172 embryonic body morphogenesis 1/1165 10/18722 0.474090044563927 0.693166819520011 DAG1 1 GO:0010728 regulation of hydrogen peroxide biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 SOD2 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/1165 10/18722 0.474090044563927 0.693166819520011 SLC2A1 1 GO:0016559 peroxisome fission 1/1165 10/18722 0.474090044563927 0.693166819520011 FIS1 1 GO:0017085 response to insecticide 1/1165 10/18722 0.474090044563927 0.693166819520011 CCNB1 1 GO:0019062 virion attachment to host cell 1/1165 10/18722 0.474090044563927 0.693166819520011 HSP90AB1 1 GO:0019532 oxalate transport 1/1165 10/18722 0.474090044563927 0.693166819520011 SLC26A2 1 GO:0019614 catechol-containing compound catabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 COMT 1 GO:0021548 pons development 1/1165 10/18722 0.474090044563927 0.693166819520011 UQCRQ 1 GO:0022400 regulation of rhodopsin mediated signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 NMT1 1 GO:0030638 polyketide metabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 AKR1B1 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 AKR1B1 1 GO:0031118 rRNA pseudouridine synthesis 1/1165 10/18722 0.474090044563927 0.693166819520011 NHP2 1 GO:0031125 rRNA 3'-end processing 1/1165 10/18722 0.474090044563927 0.693166819520011 RPS21 1 GO:0033089 positive regulation of T cell differentiation in thymus 1/1165 10/18722 0.474090044563927 0.693166819520011 ADAM8 1 GO:0033131 regulation of glucokinase activity 1/1165 10/18722 0.474090044563927 0.693166819520011 BAD 1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 PARP9 1 GO:0035376 sterol import 1/1165 10/18722 0.474090044563927 0.693166819520011 LRP1 1 GO:0035520 monoubiquitinated protein deubiquitination 1/1165 10/18722 0.474090044563927 0.693166819520011 USP47 1 GO:0035747 natural killer cell chemotaxis 1/1165 10/18722 0.474090044563927 0.693166819520011 CCL4 1 GO:0035999 tetrahydrofolate interconversion 1/1165 10/18722 0.474090044563927 0.693166819520011 TYMS 1 GO:0042424 catecholamine catabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 COMT 1 GO:0042711 maternal behavior 1/1165 10/18722 0.474090044563927 0.693166819520011 MBD2 1 GO:0042996 regulation of Golgi to plasma membrane protein transport 1/1165 10/18722 0.474090044563927 0.693166819520011 CLN3 1 GO:0044351 macropinocytosis 1/1165 10/18722 0.474090044563927 0.693166819520011 PYCARD 1 GO:0044598 doxorubicin metabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 AKR1B1 1 GO:0044848 biological phase 1/1165 10/18722 0.474090044563927 0.693166819520011 FERMT1 1 GO:0045348 positive regulation of MHC class II biosynthetic process 1/1165 10/18722 0.474090044563927 0.693166819520011 JAK2 1 GO:0045792 negative regulation of cell size 1/1165 10/18722 0.474090044563927 0.693166819520011 RHOA 1 GO:0045843 negative regulation of striated muscle tissue development 1/1165 10/18722 0.474090044563927 0.693166819520011 TGFB1 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/1165 10/18722 0.474090044563927 0.693166819520011 PSMC6 1 GO:0048194 Golgi vesicle budding 1/1165 10/18722 0.474090044563927 0.693166819520011 TMED9 1 GO:0048672 positive regulation of collateral sprouting 1/1165 10/18722 0.474090044563927 0.693166819520011 LRP1 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 SLC39A10 1 GO:0051660 establishment of centrosome localization 1/1165 10/18722 0.474090044563927 0.693166819520011 DLG1 1 GO:0060068 vagina development 1/1165 10/18722 0.474090044563927 0.693166819520011 LRP2 1 GO:0060272 embryonic skeletal joint morphogenesis 1/1165 10/18722 0.474090044563927 0.693166819520011 BMP7 1 GO:0060513 prostatic bud formation 1/1165 10/18722 0.474090044563927 0.693166819520011 BMP7 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/1165 10/18722 0.474090044563927 0.693166819520011 SERPINF1 1 GO:0060923 cardiac muscle cell fate commitment 1/1165 10/18722 0.474090044563927 0.693166819520011 TBX3 1 GO:0060947 cardiac vascular smooth muscle cell differentiation 1/1165 10/18722 0.474090044563927 0.693166819520011 VEGFA 1 GO:0061085 regulation of histone H3-K27 methylation 1/1165 10/18722 0.474090044563927 0.693166819520011 GATA3 1 GO:0061621 canonical glycolysis 1/1165 10/18722 0.474090044563927 0.693166819520011 ENO1 1 GO:0061718 glucose catabolic process to pyruvate 1/1165 10/18722 0.474090044563927 0.693166819520011 ENO1 1 GO:0070091 glucagon secretion 1/1165 10/18722 0.474090044563927 0.693166819520011 SYT7 1 GO:0070092 regulation of glucagon secretion 1/1165 10/18722 0.474090044563927 0.693166819520011 SYT7 1 GO:0070099 regulation of chemokine-mediated signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 TREM2 1 GO:0070383 DNA cytosine deamination 1/1165 10/18722 0.474090044563927 0.693166819520011 APOBEC3A 1 GO:0070508 cholesterol import 1/1165 10/18722 0.474090044563927 0.693166819520011 LRP1 1 GO:0071233 cellular response to leucine 1/1165 10/18722 0.474090044563927 0.693166819520011 SESN1 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/1165 10/18722 0.474090044563927 0.693166819520011 GCLM 1 GO:0072070 loop of Henle development 1/1165 10/18722 0.474090044563927 0.693166819520011 IRX2 1 GO:0072124 regulation of glomerular mesangial cell proliferation 1/1165 10/18722 0.474090044563927 0.693166819520011 BMP7 1 GO:0072378 blood coagulation, fibrin clot formation 1/1165 10/18722 0.474090044563927 0.693166819520011 FBLN1 1 GO:0090037 positive regulation of protein kinase C signaling 1/1165 10/18722 0.474090044563927 0.693166819520011 VEGFA 1 GO:0090043 regulation of tubulin deacetylation 1/1165 10/18722 0.474090044563927 0.693166819520011 BEX4 1 GO:0097084 vascular associated smooth muscle cell development 1/1165 10/18722 0.474090044563927 0.693166819520011 VEGFA 1 GO:0097250 mitochondrial respirasome assembly 1/1165 10/18722 0.474090044563927 0.693166819520011 COX7A2 1 GO:0098903 regulation of membrane repolarization during action potential 1/1165 10/18722 0.474090044563927 0.693166819520011 FLNA 1 GO:0098917 retrograde trans-synaptic signaling 1/1165 10/18722 0.474090044563927 0.693166819520011 DAG1 1 GO:0150172 regulation of phosphatidylcholine metabolic process 1/1165 10/18722 0.474090044563927 0.693166819520011 APOC1 1 GO:1900246 positive regulation of RIG-I signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 OASL 1 GO:1901725 regulation of histone deacetylase activity 1/1165 10/18722 0.474090044563927 0.693166819520011 VEGFA 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1165 10/18722 0.474090044563927 0.693166819520011 NCL 1 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 PMAIP1 1 GO:1902855 regulation of non-motile cilium assembly 1/1165 10/18722 0.474090044563927 0.693166819520011 ATMIN 1 GO:1903826 arginine transmembrane transport 1/1165 10/18722 0.474090044563927 0.693166819520011 SLC38A9 1 GO:1903980 positive regulation of microglial cell activation 1/1165 10/18722 0.474090044563927 0.693166819520011 TREM2 1 GO:1904851 positive regulation of establishment of protein localization to telomere 1/1165 10/18722 0.474090044563927 0.693166819520011 CCT2 1 GO:1905941 positive regulation of gonad development 1/1165 10/18722 0.474090044563927 0.693166819520011 RETN 1 GO:1990535 neuron projection maintenance 1/1165 10/18722 0.474090044563927 0.693166819520011 APP 1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin 1/1165 10/18722 0.474090044563927 0.693166819520011 VEGFA 1 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 1/1165 10/18722 0.474090044563927 0.693166819520011 ATP2B4 1 GO:2000252 negative regulation of feeding behavior 1/1165 10/18722 0.474090044563927 0.693166819520011 RETN 1 GO:2000288 positive regulation of myoblast proliferation 1/1165 10/18722 0.474090044563927 0.693166819520011 MALAT1 1 GO:2001223 negative regulation of neuron migration 1/1165 10/18722 0.474090044563927 0.693166819520011 ADGRG1 1 GO:2001225 regulation of chloride transport 1/1165 10/18722 0.474090044563927 0.693166819520011 GABRE 1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1/1165 10/18722 0.474090044563927 0.693166819520011 JAK2 1 GO:0050804 modulation of chemical synaptic transmission 28/1165 439/18722 0.474332673358372 0.693340962385557 CDH1/EGFR/SRGN/MME/SLC6A4/NSG1/TYROBP/APP/PRKCZ/SYT7/GNAI1/APOE/ITGB1/PTN/LGMN/PNKD/EIF2AK4/AKAP9/SLC1A3/LILRB2/RETN/HRAS/PTPRA/GNAI2/GLUL/CLN3/RAB11A/JAK2 28 GO:0008643 carbohydrate transport 10/1165 152/18722 0.474881852733137 0.693962988646472 SLC2A1/SORBS1/GPC3/SLC35B4/SLC5A3/YES1/SLC2A3/OPN3/PEA15/AQP9 10 GO:0055001 muscle cell development 12/1165 184/18722 0.47617900997135 0.69567745522363 ISL1/KRT8/OBSL1/CSRP2/TBX3/ITGB1/GPX1/VEGFA/AFG3L2/KRT19/SLC8A1/CCNB1 12 GO:0060042 retina morphogenesis in camera-type eye 4/1165 57/18722 0.477371382159824 0.697237982842335 LRP5/TFAP2A/OBSL1/PTN 4 GO:0019932 second-messenger-mediated signaling 20/1165 312/18722 0.478589000157345 0.698834562404573 EGFR/CXCR4/GNAI1/SLC9A1/NUDT4/APOE/GBP1/VEGFA/PTPRC/ATP2B4/CIB1/GSTO1/TREM2/FPR1/NFAT5/CCL4/FIS1/DEFB1/SLC8A1/SYK 20 GO:0099177 regulation of trans-synaptic signaling 28/1165 440/18722 0.479298354605526 0.699688339245986 CDH1/EGFR/SRGN/MME/SLC6A4/NSG1/TYROBP/APP/PRKCZ/SYT7/GNAI1/APOE/ITGB1/PTN/LGMN/PNKD/EIF2AK4/AKAP9/SLC1A3/LILRB2/RETN/HRAS/PTPRA/GNAI2/GLUL/CLN3/RAB11A/JAK2 28 GO:0010657 muscle cell apoptotic process 6/1165 89/18722 0.480749932647071 0.701442519352225 BMP7/SOD2/PDCD4/DNMT1/BNIP3/JAK2 6 GO:0051781 positive regulation of cell division 6/1165 89/18722 0.480749932647071 0.701442519352225 PTN/RHOA/VEGFA/TGFB1/IGF2/YBX1 6 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 7/1165 105/18722 0.481684839937407 0.702623962205994 NRP1/FNBP1L/EPS8/ATMIN/WASF2/HRAS/WASL 7 GO:0048706 embryonic skeletal system development 8/1165 121/18722 0.482366487329601 0.702716654042381 PBX1/BMP7/TFAP2A/GLI3/KIAA1217/DLG1/SLC39A1/SULF2 8 GO:0043433 negative regulation of DNA-binding transcription factor activity 12/1165 185/18722 0.483805522548548 0.702716654042381 BMP7/TMSB4X/PRDX2/NFKBIA/ID1/FLNA/SPI1/EIF2AK4/KLF4/PYCARD/HDAC2/UFL1 12 GO:0002092 positive regulation of receptor internalization 2/1165 26/18722 0.487321242963197 0.702716654042381 VEGFA/SYK 2 GO:0006517 protein deglycosylation 2/1165 26/18722 0.487321242963197 0.702716654042381 MAN1A2/PARK7 2 GO:0006706 steroid catabolic process 2/1165 26/18722 0.487321242963197 0.702716654042381 APOE/HSD17B11 2 GO:0007214 gamma-aminobutyric acid signaling pathway 2/1165 26/18722 0.487321242963197 0.702716654042381 GABRE/GNAI2 2 GO:0016226 iron-sulfur cluster assembly 2/1165 26/18722 0.487321242963197 0.702716654042381 GLRX5/ISCU 2 GO:0021680 cerebellar Purkinje cell layer development 2/1165 26/18722 0.487321242963197 0.702716654042381 UQCRQ/HSPA5 2 GO:0031163 metallo-sulfur cluster assembly 2/1165 26/18722 0.487321242963197 0.702716654042381 GLRX5/ISCU 2 GO:0032515 negative regulation of phosphoprotein phosphatase activity 2/1165 26/18722 0.487321242963197 0.702716654042381 LGALS3/GNAI2 2 GO:0048668 collateral sprouting 2/1165 26/18722 0.487321242963197 0.702716654042381 APP/LRP1 2 GO:0051350 negative regulation of lyase activity 2/1165 26/18722 0.487321242963197 0.702716654042381 AKAP9/GNAI2 2 GO:0051875 pigment granule localization 2/1165 26/18722 0.487321242963197 0.702716654042381 MYO7A/RAB11A 2 GO:0060295 regulation of cilium movement involved in cell motility 2/1165 26/18722 0.487321242963197 0.702716654042381 DEFB1/CATSPER1 2 GO:0060352 cell adhesion molecule production 2/1165 26/18722 0.487321242963197 0.702716654042381 COLEC12/PPIA 2 GO:0070977 bone maturation 2/1165 26/18722 0.487321242963197 0.702716654042381 SNX10/RHOA 2 GO:0072273 metanephric nephron morphogenesis 2/1165 26/18722 0.487321242963197 0.702716654042381 LGR4/STAT1 2 GO:0097186 amelogenesis 2/1165 26/18722 0.487321242963197 0.702716654042381 PERP/CSF3R 2 GO:0099637 neurotransmitter receptor transport 2/1165 26/18722 0.487321242963197 0.702716654042381 NSG1/RAB11A 2 GO:1900017 positive regulation of cytokine production involved in inflammatory response 2/1165 26/18722 0.487321242963197 0.702716654042381 GBP5/GPSM3 2 GO:1902019 regulation of cilium-dependent cell motility 2/1165 26/18722 0.487321242963197 0.702716654042381 DEFB1/CATSPER1 2 GO:1902656 calcium ion import into cytosol 2/1165 26/18722 0.487321242963197 0.702716654042381 ATP2B4/SLC8A1 2 GO:1904353 regulation of telomere capping 2/1165 26/18722 0.487321242963197 0.702716654042381 PKIB/RAD50 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/1165 26/18722 0.487321242963197 0.702716654042381 ADAM8/LYN 2 GO:0009154 purine ribonucleotide catabolic process 3/1165 42/18722 0.490043983658443 0.702716654042381 HINT1/NUDT4/PNP 3 GO:0010677 negative regulation of cellular carbohydrate metabolic process 3/1165 42/18722 0.490043983658443 0.702716654042381 FBP1/PGP/FAM3C 3 GO:0010939 regulation of necrotic cell death 3/1165 42/18722 0.490043983658443 0.702716654042381 HEBP2/TSPO/BNIP3 3 GO:0032691 negative regulation of interleukin-1 beta production 3/1165 42/18722 0.490043983658443 0.702716654042381 GSTP1/TREM2/LILRB4 3 GO:0042168 heme metabolic process 3/1165 42/18722 0.490043983658443 0.702716654042381 SLCO2B1/TSPO/UROD 3 GO:0045047 protein targeting to ER 3/1165 42/18722 0.490043983658443 0.702716654042381 HSPA5/SRPRB/SRP14 3 GO:0051452 intracellular pH reduction 3/1165 42/18722 0.490043983658443 0.702716654042381 SLC11A1/CLN3/GRN 3 GO:0060999 positive regulation of dendritic spine development 3/1165 42/18722 0.490043983658443 0.702716654042381 DLG5/APOE/DHX36 3 GO:0090317 negative regulation of intracellular protein transport 3/1165 42/18722 0.490043983658443 0.702716654042381 FERMT1/LMAN1/PARK7 3 GO:1904037 positive regulation of epithelial cell apoptotic process 3/1165 42/18722 0.490043983658443 0.702716654042381 PDCD4/BAD/JAK2 3 GO:2001222 regulation of neuron migration 3/1165 42/18722 0.490043983658443 0.702716654042381 SEMA6A/ADGRG1/FLNA 3 GO:0002931 response to ischemia 4/1165 58/18722 0.491054219836212 0.702716654042381 GJA1/HSPD1/CIB1/TREM2 4 GO:0007405 neuroblast proliferation 4/1165 58/18722 0.491054219836212 0.702716654042381 GLI3/ASPM/PTN/VEGFA 4 GO:0010574 regulation of vascular endothelial growth factor production 4/1165 58/18722 0.491054219836212 0.702716654042381 ISL1/IL6ST/TGFB1/SULF2 4 GO:0032387 negative regulation of intracellular transport 4/1165 58/18722 0.491054219836212 0.702716654042381 FERMT1/LMAN1/PARK7/SNX3 4 GO:0035904 aorta development 4/1165 58/18722 0.491054219836212 0.702716654042381 LRP2/ADAMTS6/SOX4/LRP1 4 GO:0043506 regulation of JUN kinase activity 4/1165 58/18722 0.491054219836212 0.702716654042381 PDCD4/GSTP1/RPS3/SYK 4 GO:0045604 regulation of epidermal cell differentiation 4/1165 58/18722 0.491054219836212 0.702716654042381 ESRP1/ZFP36/NCOA3/ZFP36L1 4 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 9/1165 138/18722 0.491705946699457 0.702716654042381 LAPTM5/NDFIP2/NPM1/SKP2/HSPA5/VCP/UBB/GNL3/PDCD6 9 GO:0002062 chondrocyte differentiation 7/1165 106/18722 0.491764463087965 0.702716654042381 EFEMP1/SERPINH1/GLI3/SCIN/TGFB1/CREB3L2/SULF2 7 GO:2000278 regulation of DNA biosynthetic process 7/1165 106/18722 0.491764463087965 0.702716654042381 GJA1/PKIB/HSP90AB1/DUSP1/HSP90AA1/CCT2/KLF4 7 GO:0046890 regulation of lipid biosynthetic process 11/1165 171/18722 0.499448751963457 0.702716654042381 SORBS1/SOD1/APOE/IDH1/ORMDL1/APOC1/CD74/SF1/TSPO/CGA/ACADVL 11 GO:0051147 regulation of muscle cell differentiation 10/1165 155/18722 0.499947605201261 0.702716654042381 SOD2/PDCD4/DNMT1/FOXO4/MORF4L2/TGFB1/MDM2/BHLHE41/IGF2/YBX1 10 GO:0016579 protein deubiquitination 9/1165 139/18722 0.500494559435711 0.702716654042381 USP53/USP27X/PSMD14/VCP/USP22/USP14/PARK7/USP47/BABAM1 9 GO:0030216 keratinocyte differentiation 9/1165 139/18722 0.500494559435711 0.702716654042381 DSP/EXPH5/YAP1/ZFP36/IRF6/TXNIP/OPN3/NCOA3/ZFP36L1 9 GO:0000018 regulation of DNA recombination 7/1165 107/18722 0.501784245244184 0.702716654042381 PARP1/TFRC/MAGEF1/PTPRC/FUS/RAD50/TGFB1 7 GO:0042303 molting cycle 7/1165 107/18722 0.501784245244184 0.702716654042381 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2/SNRPE 7 GO:0042633 hair cycle 7/1165 107/18722 0.501784245244184 0.702716654042381 LAMA5/EGFR/LGR5/LGR4/FERMT1/HDAC2/SNRPE 7 GO:0016050 vesicle organization 19/1165 300/18722 0.502465665477666 0.702716654042381 SRGN/SYT7/S100A10/SNX10/MYO7A/FNBP1L/VAV3/TFG/TMED9/VPS25/TRAPPC6A/WASL/SAMD9/CLN3/RAB11A/SNX3/PDCD6/CD2AP/ZEB2 19 GO:0006885 regulation of pH 6/1165 91/18722 0.502566710745146 0.702716654042381 ATP6V1B1/SLC9A1/SLC11A1/TMEM165/CLN3/GRN 6 GO:0098661 inorganic anion transmembrane transport 6/1165 91/18722 0.502566710745146 0.702716654042381 SLC26A2/SLC13A4/GABRE/SLC25A3/SLC5A6/SLC1A3 6 GO:0015850 organic hydroxy compound transport 18/1165 284/18722 0.502935957141875 0.702716654042381 SLC6A4/SYT7/LIMA1/NFKBIA/SLC5A3/APOE/APOC1/OSBPL9/SLCO2B1/SLC16A3/TREM2/PARK7/LILRB1/ACTB/TSPO/SYK/LRP1/AQP9 18 GO:0008088 axo-dendritic transport 5/1165 75/18722 0.50348333913117 0.702716654042381 APP/SOD1/ARMCX3/DST/HSPA8 5 GO:0045913 positive regulation of carbohydrate metabolic process 5/1165 75/18722 0.50348333913117 0.702716654042381 SORBS1/APP/DDB1/PMAIP1/IGF2 5 GO:0051453 regulation of intracellular pH 5/1165 75/18722 0.50348333913117 0.702716654042381 SLC9A1/SLC11A1/TMEM165/CLN3/GRN 5 GO:0046324 regulation of glucose import 4/1165 59/18722 0.504585822781396 0.702716654042381 SORBS1/GPC3/OPN3/PEA15 4 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4/1165 59/18722 0.504585822781396 0.702716654042381 FLT1/NRP1/VEGFA/PDCD6 4 GO:0031503 protein-containing complex localization 14/1165 220/18722 0.505149991286567 0.702716654042381 DAG1/NSG1/TYROBP/PRKCZ/NPM1/DLG1/RAN/AKAP9/HSPB11/HRAS/WASL/PCM1/RAB11A/NUP214 14 GO:0001709 cell fate determination 3/1165 43/18722 0.505943421983938 0.702716654042381 ISL1/GATA3/KLF4 3 GO:0014014 negative regulation of gliogenesis 3/1165 43/18722 0.505943421983938 0.702716654042381 PTN/TREM2/TSPO 3 GO:0016266 O-glycan processing 3/1165 43/18722 0.505943421983938 0.702716654042381 GALNT11/ST3GAL4/C1GALT1 3 GO:0030517 negative regulation of axon extension 3/1165 43/18722 0.505943421983938 0.702716654042381 SEMA6A/SEMA6D/NRP1 3 GO:0031952 regulation of protein autophosphorylation 3/1165 43/18722 0.505943421983938 0.702716654042381 VEGFA/PTPRC/RAD50 3 GO:0034661 ncRNA catabolic process 3/1165 43/18722 0.505943421983938 0.702716654042381 LIN28B/KCNQ1OT1/SND1 3 GO:0042088 T-helper 1 type immune response 3/1165 43/18722 0.505943421983938 0.702716654042381 HLA-DRB1/SLC11A1/HRAS 3 GO:0042181 ketone biosynthetic process 3/1165 43/18722 0.505943421983938 0.702716654042381 HSD17B1/TPI1/COQ4 3 GO:0045840 positive regulation of mitotic nuclear division 3/1165 43/18722 0.505943421983938 0.702716654042381 LRP5/ANAPC11/IGF2 3 GO:0046636 negative regulation of alpha-beta T cell activation 3/1165 43/18722 0.505943421983938 0.702716654042381 GLI3/LILRB1/CD300A 3 GO:0060443 mammary gland morphogenesis 3/1165 43/18722 0.505943421983938 0.702716654042381 LRP5/GLI3/TBX3 3 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/1165 11/18722 0.506832942067296 0.702716654042381 DDX1 1 GO:0001660 fever generation 1/1165 11/18722 0.506832942067296 0.702716654042381 PTGES 1 GO:0001765 membrane raft assembly 1/1165 11/18722 0.506832942067296 0.702716654042381 S100A10 1 GO:0001787 natural killer cell proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 HLA-E 1 GO:0001967 suckling behavior 1/1165 11/18722 0.506832942067296 0.702716654042381 APP 1 GO:0002327 immature B cell differentiation 1/1165 11/18722 0.506832942067296 0.702716654042381 SPI1 1 GO:0003263 cardioblast proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 ISL1 1 GO:0003264 regulation of cardioblast proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 ISL1 1 GO:0006054 N-acetylneuraminate metabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 NPL 1 GO:0006527 arginine catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 ATP2B4 1 GO:0006707 cholesterol catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 APOE 1 GO:0006971 hypotonic response 1/1165 11/18722 0.506832942067296 0.702716654042381 TSPO 1 GO:0007144 female meiosis I 1/1165 11/18722 0.506832942067296 0.702716654042381 UBB 1 GO:0009120 deoxyribonucleoside metabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 PNP 1 GO:0010887 negative regulation of cholesterol storage 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM2 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM2 1 GO:0014854 response to inactivity 1/1165 11/18722 0.506832942067296 0.702716654042381 DAG1 1 GO:0015810 aspartate transmembrane transport 1/1165 11/18722 0.506832942067296 0.702716654042381 SLC25A13 1 GO:0015886 heme transport 1/1165 11/18722 0.506832942067296 0.702716654042381 PGRMC2 1 GO:0016127 sterol catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 APOE 1 GO:0018026 peptidyl-lysine monomethylation 1/1165 11/18722 0.506832942067296 0.702716654042381 SMYD2 1 GO:0019048 modulation by virus of host process 1/1165 11/18722 0.506832942067296 0.702716654042381 DAG1 1 GO:0021860 pyramidal neuron development 1/1165 11/18722 0.506832942067296 0.702716654042381 UQCRQ 1 GO:0032276 regulation of gonadotropin secretion 1/1165 11/18722 0.506832942067296 0.702716654042381 GJA1 1 GO:0032308 positive regulation of prostaglandin secretion 1/1165 11/18722 0.506832942067296 0.702716654042381 PTGES 1 GO:0032836 glomerular basement membrane development 1/1165 11/18722 0.506832942067296 0.702716654042381 SULF2 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/1165 11/18722 0.506832942067296 0.702716654042381 IRF7 1 GO:0033234 negative regulation of protein sumoylation 1/1165 11/18722 0.506832942067296 0.702716654042381 PARK7 1 GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/1165 11/18722 0.506832942067296 0.702716654042381 DPP4 1 GO:0033690 positive regulation of osteoblast proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 LRP5 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/1165 11/18722 0.506832942067296 0.702716654042381 KLF4 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/1165 11/18722 0.506832942067296 0.702716654042381 RSAD2 1 GO:0034350 regulation of glial cell apoptotic process 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM2 1 GO:0034379 very-low-density lipoprotein particle assembly 1/1165 11/18722 0.506832942067296 0.702716654042381 APOC1 1 GO:0034454 microtubule anchoring at centrosome 1/1165 11/18722 0.506832942067296 0.702716654042381 PCM1 1 GO:0034969 histone arginine methylation 1/1165 11/18722 0.506832942067296 0.702716654042381 PRMT1 1 GO:0035246 peptidyl-arginine N-methylation 1/1165 11/18722 0.506832942067296 0.702716654042381 PRMT1 1 GO:0035404 histone-serine phosphorylation 1/1165 11/18722 0.506832942067296 0.702716654042381 CCNB1 1 GO:0035865 cellular response to potassium ion 1/1165 11/18722 0.506832942067296 0.702716654042381 SOD1 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/1165 11/18722 0.506832942067296 0.702716654042381 EIF2AK4 1 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/1165 11/18722 0.506832942067296 0.702716654042381 C1QBP 1 GO:0042135 neurotransmitter catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 COMT 1 GO:0042167 heme catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 SLCO2B1 1 GO:0042447 hormone catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 HSD17B11 1 GO:0042789 mRNA transcription by RNA polymerase II 1/1165 11/18722 0.506832942067296 0.702716654042381 FLNA 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/1165 11/18722 0.506832942067296 0.702716654042381 EPAS1 1 GO:0046149 pigment catabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 SLCO2B1 1 GO:0046349 amino sugar biosynthetic process 1/1165 11/18722 0.506832942067296 0.702716654042381 GFPT1 1 GO:0046710 GDP metabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 DLG1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/1165 11/18722 0.506832942067296 0.702716654042381 PNKD 1 GO:0048635 negative regulation of muscle organ development 1/1165 11/18722 0.506832942067296 0.702716654042381 TGFB1 1 GO:0051132 NK T cell activation 1/1165 11/18722 0.506832942067296 0.702716654042381 CD300A 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/1165 11/18722 0.506832942067296 0.702716654042381 DNMT1 1 GO:0051610 serotonin uptake 1/1165 11/18722 0.506832942067296 0.702716654042381 SLC6A4 1 GO:0052646 alditol phosphate metabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 GK 1 GO:0055015 ventricular cardiac muscle cell development 1/1165 11/18722 0.506832942067296 0.702716654042381 CCNB1 1 GO:0060174 limb bud formation 1/1165 11/18722 0.506832942067296 0.702716654042381 SOX4 1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/1165 11/18722 0.506832942067296 0.702716654042381 GSTO1 1 GO:0060379 cardiac muscle cell myoblast differentiation 1/1165 11/18722 0.506832942067296 0.702716654042381 ISL1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/1165 11/18722 0.506832942067296 0.702716654042381 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/1165 11/18722 0.506832942067296 0.702716654042381 GLI3 1 GO:0060746 parental behavior 1/1165 11/18722 0.506832942067296 0.702716654042381 MBD2 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/1165 11/18722 0.506832942067296 0.702716654042381 SERPINF1 1 GO:0060837 blood vessel endothelial cell differentiation 1/1165 11/18722 0.506832942067296 0.702716654042381 NRP1 1 GO:0060900 embryonic camera-type eye formation 1/1165 11/18722 0.506832942067296 0.702716654042381 TFAP2A 1 GO:0061314 Notch signaling involved in heart development 1/1165 11/18722 0.506832942067296 0.702716654042381 GALNT11 1 GO:0070189 kynurenine metabolic process 1/1165 11/18722 0.506832942067296 0.702716654042381 KYNU 1 GO:0070203 regulation of establishment of protein localization to telomere 1/1165 11/18722 0.506832942067296 0.702716654042381 CCT2 1 GO:0070341 fat cell proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM2 1 GO:0070344 regulation of fat cell proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM2 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/1165 11/18722 0.506832942067296 0.702716654042381 KLF4 1 GO:0070601 centromeric sister chromatid cohesion 1/1165 11/18722 0.506832942067296 0.702716654042381 NAA10 1 GO:0070933 histone H4 deacetylation 1/1165 11/18722 0.506832942067296 0.702716654042381 HDAC2 1 GO:0070944 neutrophil-mediated killing of bacterium 1/1165 11/18722 0.506832942067296 0.702716654042381 TREM1 1 GO:0071313 cellular response to caffeine 1/1165 11/18722 0.506832942067296 0.702716654042381 SLC8A1 1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 1/1165 11/18722 0.506832942067296 0.702716654042381 PTN 1 GO:0071377 cellular response to glucagon stimulus 1/1165 11/18722 0.506832942067296 0.702716654042381 ASS1 1 GO:0072110 glomerular mesangial cell proliferation 1/1165 11/18722 0.506832942067296 0.702716654042381 BMP7 1 GO:0072173 metanephric tubule morphogenesis 1/1165 11/18722 0.506832942067296 0.702716654042381 LGR4 1 GO:0072497 mesenchymal stem cell differentiation 1/1165 11/18722 0.506832942067296 0.702716654042381 KRT18 1 GO:0072697 protein localization to cell cortex 1/1165 11/18722 0.506832942067296 0.702716654042381 GNAI1 1 GO:0075522 IRES-dependent viral translational initiation 1/1165 11/18722 0.506832942067296 0.702716654042381 EIF3A 1 GO:0075733 intracellular transport of virus 1/1165 11/18722 0.506832942067296 0.702716654042381 BST2 1 GO:0086016 AV node cell action potential 1/1165 11/18722 0.506832942067296 0.702716654042381 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/1165 11/18722 0.506832942067296 0.702716654042381 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/1165 11/18722 0.506832942067296 0.702716654042381 GJA5 1 GO:0090084 negative regulation of inclusion body assembly 1/1165 11/18722 0.506832942067296 0.702716654042381 SORL1 1 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 1/1165 11/18722 0.506832942067296 0.702716654042381 DNMT1 1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/1165 11/18722 0.506832942067296 0.702716654042381 SLC35B4 1 GO:0090649 response to oxygen-glucose deprivation 1/1165 11/18722 0.506832942067296 0.702716654042381 BNIP3 1 GO:0097494 regulation of vesicle size 1/1165 11/18722 0.506832942067296 0.702716654042381 RAB11A 1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 1/1165 11/18722 0.506832942067296 0.702716654042381 SLC8A1 1 GO:0099624 atrial cardiac muscle cell membrane repolarization 1/1165 11/18722 0.506832942067296 0.702716654042381 FLNA 1 GO:1900222 negative regulation of amyloid-beta clearance 1/1165 11/18722 0.506832942067296 0.702716654042381 LRPAP1 1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 1/1165 11/18722 0.506832942067296 0.702716654042381 GBP5 1 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/1165 11/18722 0.506832942067296 0.702716654042381 NMT1 1 GO:1901862 negative regulation of muscle tissue development 1/1165 11/18722 0.506832942067296 0.702716654042381 TGFB1 1 GO:1902065 response to L-glutamate 1/1165 11/18722 0.506832942067296 0.702716654042381 UFL1 1 GO:1902093 positive regulation of flagellated sperm motility 1/1165 11/18722 0.506832942067296 0.702716654042381 DEFB1 1 GO:1902188 positive regulation of viral release from host cell 1/1165 11/18722 0.506832942067296 0.702716654042381 DDB1 1 GO:1902915 negative regulation of protein polyubiquitination 1/1165 11/18722 0.506832942067296 0.702716654042381 PPIA 1 GO:1903238 positive regulation of leukocyte tethering or rolling 1/1165 11/18722 0.506832942067296 0.702716654042381 ST3GAL4 1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1/1165 11/18722 0.506832942067296 0.702716654042381 LAPTM5 1 GO:1903299 regulation of hexokinase activity 1/1165 11/18722 0.506832942067296 0.702716654042381 BAD 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/1165 11/18722 0.506832942067296 0.702716654042381 HSPA5 1 GO:1904464 regulation of matrix metallopeptidase secretion 1/1165 11/18722 0.506832942067296 0.702716654042381 TLR2 1 GO:1904869 regulation of protein localization to Cajal body 1/1165 11/18722 0.506832942067296 0.702716654042381 CCT2 1 GO:1904871 positive regulation of protein localization to Cajal body 1/1165 11/18722 0.506832942067296 0.702716654042381 CCT2 1 GO:1905050 positive regulation of metallopeptidase activity 1/1165 11/18722 0.506832942067296 0.702716654042381 CLDN4 1 GO:1990773 matrix metallopeptidase secretion 1/1165 11/18722 0.506832942067296 0.702716654042381 TLR2 1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/1165 11/18722 0.506832942067296 0.702716654042381 TJP1 1 GO:2000155 positive regulation of cilium-dependent cell motility 1/1165 11/18722 0.506832942067296 0.702716654042381 DEFB1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/1165 11/18722 0.506832942067296 0.702716654042381 PKIB 1 GO:2000615 regulation of histone H3-K9 acetylation 1/1165 11/18722 0.506832942067296 0.702716654042381 GATA3 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/1165 11/18722 0.506832942067296 0.702716654042381 BMP7 1 GO:0000469 cleavage involved in rRNA processing 2/1165 27/18722 0.507538449222842 0.702716654042381 RPS21/NHP2 2 GO:0003272 endocardial cushion formation 2/1165 27/18722 0.507538449222842 0.702716654042381 BMP7/TBX3 2 GO:0006783 heme biosynthetic process 2/1165 27/18722 0.507538449222842 0.702716654042381 TSPO/UROD 2 GO:0010894 negative regulation of steroid biosynthetic process 2/1165 27/18722 0.507538449222842 0.702716654042381 SOD1/APOE 2 GO:0018195 peptidyl-arginine modification 2/1165 27/18722 0.507538449222842 0.702716654042381 PARK7/PRMT1 2 GO:0031954 positive regulation of protein autophosphorylation 2/1165 27/18722 0.507538449222842 0.702716654042381 VEGFA/RAD50 2 GO:0034453 microtubule anchoring 2/1165 27/18722 0.507538449222842 0.702716654042381 DAG1/PCM1 2 GO:0035116 embryonic hindlimb morphogenesis 2/1165 27/18722 0.507538449222842 0.702716654042381 GPC3/TBX3 2 GO:0035235 ionotropic glutamate receptor signaling pathway 2/1165 27/18722 0.507538449222842 0.702716654042381 APP/CLN3 2 GO:0042403 thyroid hormone metabolic process 2/1165 27/18722 0.507538449222842 0.702716654042381 GATA3/CGA 2 GO:0046174 polyol catabolic process 2/1165 27/18722 0.507538449222842 0.702716654042381 TPI1/GK 2 GO:0048520 positive regulation of behavior 2/1165 27/18722 0.507538449222842 0.702716654042381 GJA1/HDAC2 2 GO:0060512 prostate gland morphogenesis 2/1165 27/18722 0.507538449222842 0.702716654042381 BMP7/CRIP1 2 GO:0071624 positive regulation of granulocyte chemotaxis 2/1165 27/18722 0.507538449222842 0.702716654042381 C1QBP/CD74 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/1165 27/18722 0.507538449222842 0.702716654042381 GJA5/AKAP9 2 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 2/1165 27/18722 0.507538449222842 0.702716654042381 AKAP9/TREM2 2 GO:1902883 negative regulation of response to oxidative stress 2/1165 27/18722 0.507538449222842 0.702716654042381 MET/PARK7 2 GO:1902914 regulation of protein polyubiquitination 2/1165 27/18722 0.507538449222842 0.702716654042381 SKP2/PPIA 2 GO:0006958 complement activation, classical pathway 7/1165 108/18722 0.511738924117455 0.708357726528059 C1QA/C1QB/C1QC/C1QBP/CD55/CD46/TREM2 7 GO:0051056 regulation of small GTPase mediated signal transduction 19/1165 302/18722 0.51440814847549 0.711876956950918 ADGRG1/KANK1/MET/SYDE2/AMOT/RASA1/NRP1/NET1/APOE/ITGB1/FBP1/FAM13A/TGM2/VAV3/EPS8/ARHGDIB/HRAS/STMN1/CD2AP 19 GO:0001937 negative regulation of endothelial cell proliferation 5/1165 76/18722 0.515354254221241 0.712659134994784 NR2F2/GJA1/FLT1/APOE/STAT1 5 GO:0014855 striated muscle cell proliferation 5/1165 76/18722 0.515354254221241 0.712659134994784 TGFBR3/GJA1/YAP1/JAK2/CCNB1 5 GO:0032720 negative regulation of tumor necrosis factor production 5/1165 76/18722 0.515354254221241 0.712659134994784 GSTP1/PTPN6/TREM2/LILRB1/TSPO 5 GO:0006644 phospholipid metabolic process 24/1165 383/18722 0.516389155226748 0.713864942846583 ISYNA1/PLPP3/FDFT1/PGAP2/DBI/SH3YL1/IDH1/PISD/GPAA1/FDPS/PGP/SLC44A2/SERINC2/PLSCR1/APOC1/PIK3C2A/TMEM150A/GPX4/GPCPD1/STOML2/PMVK/PRDX6/CLN3/SOCS3 24 GO:0070646 protein modification by small protein removal 10/1165 157/18722 0.516480586655972 0.713864942846583 USP53/USP27X/HINT1/PSMD14/VCP/USP22/USP14/PARK7/USP47/BABAM1 10 GO:0048284 organelle fusion 9/1165 141/18722 0.517937989512252 0.715199008063985 SYT7/TFRC/VAV3/AFG3L2/STOML2/SAMD9/FIS1/CLN3/BNIP3 9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 4/1165 60/18722 0.517955454797808 0.715199008063985 FOXO4/USP47/RAD21/BABAM1 4 GO:0035825 homologous recombination 4/1165 60/18722 0.517955454797808 0.715199008063985 RAD50/NUCKS1/RAD21/TOP2A 4 GO:0060038 cardiac muscle cell proliferation 4/1165 60/18722 0.517955454797808 0.715199008063985 TGFBR3/GJA1/YAP1/CCNB1 4 GO:0009566 fertilization 12/1165 190/18722 0.521554805130764 0.716676004460028 NR2F2/SPESP1/FOLR1/ALDOA/SLIRP/PITHD1/CCT2/CD9/SNU13/CD46/PARK7/LHFPL2 12 GO:0048066 developmental pigmentation 3/1165 44/18722 0.521581108011093 0.716676004460028 GLI3/GNA11/ZEB2 3 GO:0060324 face development 3/1165 44/18722 0.521581108011093 0.716676004460028 ARID5B/DLX5/RRAS 3 GO:0089718 amino acid import across plasma membrane 3/1165 44/18722 0.521581108011093 0.716676004460028 ITGB1/ARL6IP5/SLC1A3 3 GO:0006821 chloride transport 7/1165 109/18722 0.521623450436712 0.716676004460028 SLC26A2/CLDN4/FXYD3/CLIC3/GABRE/SLC1A3/TSPO 7 GO:0034766 negative regulation of ion transmembrane transport 7/1165 109/18722 0.521623450436712 0.716676004460028 ANK3/C4orf3/ARL6IP5/GSTO1/YWHAE/ISCU/VDAC1 7 GO:0060349 bone morphogenesis 6/1165 93/18722 0.524049646040906 0.716676004460028 LRP5/SERPINH1/TFAP2A/GLI3/MSX2/DLX5 6 GO:0016311 dephosphorylation 26/1165 417/18722 0.525250862987909 0.716676004460028 CTDSPL/PTPN14/SLC39A10/HSP90B1/HSP90AB1/DUSP5/PLPP3/DUSP14/DUSP1/FBP1/DLG1/PGP/PTPRC/LGALS3/CAMK2G/PTPN6/TGFB1/LILRB2/PTPRA/PPIA/GNAI2/YWHAE/PTP4A1/CD300A/JAK2/ENSA 26 GO:0097553 calcium ion transmembrane import into cytosol 9/1165 142/18722 0.526585700573864 0.716676004460028 CYBA/PTPRC/ATP2B4/PTPN6/GSTO1/ERO1A/CXCL10/SLC8A1/LYN 9 GO:0010827 regulation of glucose transmembrane transport 5/1165 77/18722 0.527105126031802 0.716676004460028 SORBS1/GPC3/YES1/OPN3/PEA15 5 GO:0000423 mitophagy 2/1165 28/18722 0.527227172295425 0.716676004460028 SLC25A5/VDAC1 2 GO:0002313 mature B cell differentiation involved in immune response 2/1165 28/18722 0.527227172295425 0.716676004460028 SPI1/DOCK10 2 GO:0006972 hyperosmotic response 2/1165 28/18722 0.527227172295425 0.716676004460028 SLC2A1/AKR1B1 2 GO:0008299 isoprenoid biosynthetic process 2/1165 28/18722 0.527227172295425 0.716676004460028 FDPS/PMVK 2 GO:0009065 glutamine family amino acid catabolic process 2/1165 28/18722 0.527227172295425 0.716676004460028 ATP2B4/GLUL 2 GO:0010460 positive regulation of heart rate 2/1165 28/18722 0.527227172295425 0.716676004460028 ADRB1/GCH1 2 GO:0010818 T cell chemotaxis 2/1165 28/18722 0.527227172295425 0.716676004460028 CXCL10/CXCL16 2 GO:0010884 positive regulation of lipid storage 2/1165 28/18722 0.527227172295425 0.716676004460028 HILPDA/PLIN2 2 GO:0030262 apoptotic nuclear changes 2/1165 28/18722 0.527227172295425 0.716676004460028 BLCAP/TOP2A 2 GO:0032438 melanosome organization 2/1165 28/18722 0.527227172295425 0.716676004460028 TRAPPC6A/ZEB2 2 GO:0042983 amyloid precursor protein biosynthetic process 2/1165 28/18722 0.527227172295425 0.716676004460028 PAWR/ITM2C 2 GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/1165 28/18722 0.527227172295425 0.716676004460028 PAWR/ITM2C 2 GO:0044331 cell-cell adhesion mediated by cadherin 2/1165 28/18722 0.527227172295425 0.716676004460028 TJP1/VEGFA 2 GO:0060259 regulation of feeding behavior 2/1165 28/18722 0.527227172295425 0.716676004460028 EIF2AK4/RETN 2 GO:0086011 membrane repolarization during action potential 2/1165 28/18722 0.527227172295425 0.716676004460028 FLNA/YWHAE 2 GO:1903671 negative regulation of sprouting angiogenesis 2/1165 28/18722 0.527227172295425 0.716676004460028 SEMA6A/KLF2 2 GO:1990776 response to angiotensin 2/1165 28/18722 0.527227172295425 0.716676004460028 CYBA/CYBB 2 GO:0019748 secondary metabolic process 4/1165 61/18722 0.53115322397239 0.716676004460028 AKR1B1/OPN3/ARL1/ZEB2 4 GO:1904356 regulation of telomere maintenance via telomere lengthening 4/1165 61/18722 0.53115322397239 0.716676004460028 PKIB/PARP1/CCT2/DHX36 4 GO:0034249 negative regulation of cellular amide metabolic process 17/1165 273/18722 0.534832687116306 0.716676004460028 IGF2BP3/GAPDH/APOE/ZFP36/ORMDL1/EIF2AK1/DHX36/EIF2AK4/PABPC1/CALR/YBX1/TYMS/NCL/ZFP36L1/RPS3/CIRBP/SORL1 17 GO:0034763 negative regulation of transmembrane transport 9/1165 143/18722 0.535179532767978 0.716676004460028 ANK3/OAZ1/C4orf3/ARL6IP5/GSTO1/YWHAE/ISCU/VDAC1/PEA15 9 GO:0070555 response to interleukin-1 9/1165 143/18722 0.535179532767978 0.716676004460028 APP/CYBA/GBP2/KLF2/CEBPB/GBP1/CCL3L3/PYCARD/CCL4 9 GO:0003009 skeletal muscle contraction 3/1165 45/18722 0.536944264018252 0.716676004460028 GSTO1/C12orf57/NR4A1 3 GO:0022602 ovulation cycle process 3/1165 45/18722 0.536944264018252 0.716676004460028 ADAMTS1/HSPA5/RETN 3 GO:0045933 positive regulation of muscle contraction 3/1165 45/18722 0.536944264018252 0.716676004460028 RHOA/GSTO1/ENO1 3 GO:0060119 inner ear receptor cell development 3/1165 45/18722 0.536944264018252 0.716676004460028 SOD1/MYO7A/TRIOBP 3 GO:0085029 extracellular matrix assembly 3/1165 45/18722 0.536944264018252 0.716676004460028 LAMB1/DAG1/TGFB1 3 GO:0009100 glycoprotein metabolic process 24/1165 387/18722 0.537473946949292 0.716676004460028 CHPF/CTSL/TUSC3/EXTL2/PAWR/GALNT11/GPC1/DDOST/RPN2/ITM2C/FUT8/GFPT1/MAN1A2/CST3/SERP1/GANAB/ST3GAL4/OSTC/PARK7/C1GALT1/TMEM165/SULF2/MGAT1/GAL3ST4 24 GO:0000012 single strand break repair 1/1165 12/18722 0.537538923708662 0.716676004460028 PARP1 1 GO:0001821 histamine secretion 1/1165 12/18722 0.537538923708662 0.716676004460028 LYN 1 GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure 1/1165 12/18722 0.537538923708662 0.716676004460028 SOD2 1 GO:0002182 cytoplasmic translational elongation 1/1165 12/18722 0.537538923708662 0.716676004460028 RPLP2 1 GO:0002674 negative regulation of acute inflammatory response 1/1165 12/18722 0.537538923708662 0.716676004460028 GSTP1 1 GO:0003207 cardiac chamber formation 1/1165 12/18722 0.537538923708662 0.716676004460028 SOX4 1 GO:0003353 positive regulation of cilium movement 1/1165 12/18722 0.537538923708662 0.716676004460028 DEFB1 1 GO:0006068 ethanol catabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 ALDH2 1 GO:0006216 cytidine catabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 APOBEC3A 1 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 1/1165 12/18722 0.537538923708662 0.716676004460028 HSPA5 1 GO:0006787 porphyrin-containing compound catabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 SLCO2B1 1 GO:0007320 insemination 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC6A4 1 GO:0009972 cytidine deamination 1/1165 12/18722 0.537538923708662 0.716676004460028 APOBEC3A 1 GO:0010623 programmed cell death involved in cell development 1/1165 12/18722 0.537538923708662 0.716676004460028 PRKDC 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/1165 12/18722 0.537538923708662 0.716676004460028 LRP1 1 GO:0010826 negative regulation of centrosome duplication 1/1165 12/18722 0.537538923708662 0.716676004460028 NPM1 1 GO:0014831 gastro-intestinal system smooth muscle contraction 1/1165 12/18722 0.537538923708662 0.716676004460028 SULF2 1 GO:0015780 nucleotide-sugar transmembrane transport 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC35B4 1 GO:0019627 urea metabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 ASS1 1 GO:0021527 spinal cord association neuron differentiation 1/1165 12/18722 0.537538923708662 0.716676004460028 LMO4 1 GO:0021670 lateral ventricle development 1/1165 12/18722 0.537538923708662 0.716676004460028 CDK6 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC6A4 1 GO:0021978 telencephalon regionalization 1/1165 12/18722 0.537538923708662 0.716676004460028 ADGRG1 1 GO:0030238 male sex determination 1/1165 12/18722 0.537538923708662 0.716676004460028 SF1 1 GO:0030259 lipid glycosylation 1/1165 12/18722 0.537538923708662 0.716676004460028 ST3GAL4 1 GO:0031223 auditory behavior 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC1A3 1 GO:0031453 positive regulation of heterochromatin assembly 1/1165 12/18722 0.537538923708662 0.716676004460028 DNMT1 1 GO:0031953 negative regulation of protein autophosphorylation 1/1165 12/18722 0.537538923708662 0.716676004460028 PTPRC 1 GO:0032096 negative regulation of response to food 1/1165 12/18722 0.537538923708662 0.716676004460028 NENF 1 GO:0032099 negative regulation of appetite 1/1165 12/18722 0.537538923708662 0.716676004460028 NENF 1 GO:0032105 negative regulation of response to extracellular stimulus 1/1165 12/18722 0.537538923708662 0.716676004460028 NENF 1 GO:0032108 negative regulation of response to nutrient levels 1/1165 12/18722 0.537538923708662 0.716676004460028 NENF 1 GO:0032306 regulation of prostaglandin secretion 1/1165 12/18722 0.537538923708662 0.716676004460028 PTGES 1 GO:0032780 negative regulation of ATPase activity 1/1165 12/18722 0.537538923708662 0.716676004460028 CNN3 1 GO:0033004 negative regulation of mast cell activation 1/1165 12/18722 0.537538923708662 0.716676004460028 CD300A 1 GO:0033015 tetrapyrrole catabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 SLCO2B1 1 GO:0033127 regulation of histone phosphorylation 1/1165 12/18722 0.537538923708662 0.716676004460028 CCNB1 1 GO:0033182 regulation of histone ubiquitination 1/1165 12/18722 0.537538923708662 0.716676004460028 PARK7 1 GO:0033235 positive regulation of protein sumoylation 1/1165 12/18722 0.537538923708662 0.716676004460028 GNL3 1 GO:0033629 negative regulation of cell adhesion mediated by integrin 1/1165 12/18722 0.537538923708662 0.716676004460028 JAM3 1 GO:0034086 maintenance of sister chromatid cohesion 1/1165 12/18722 0.537538923708662 0.716676004460028 NAA10 1 GO:0034088 maintenance of mitotic sister chromatid cohesion 1/1165 12/18722 0.537538923708662 0.716676004460028 NAA10 1 GO:0034154 toll-like receptor 7 signaling pathway 1/1165 12/18722 0.537538923708662 0.716676004460028 RSAD2 1 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1/1165 12/18722 0.537538923708662 0.716676004460028 APOE 1 GO:0034372 very-low-density lipoprotein particle remodeling 1/1165 12/18722 0.537538923708662 0.716676004460028 APOE 1 GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/1165 12/18722 0.537538923708662 0.716676004460028 DNMT1 1 GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/1165 12/18722 0.537538923708662 0.716676004460028 CD55 1 GO:0042117 monocyte activation 1/1165 12/18722 0.537538923708662 0.716676004460028 LILRB4 1 GO:0042762 regulation of sulfur metabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 COMT 1 GO:0043248 proteasome assembly 1/1165 12/18722 0.537538923708662 0.716676004460028 PSMG1 1 GO:0044650 adhesion of symbiont to host cell 1/1165 12/18722 0.537538923708662 0.716676004460028 HSP90AB1 1 GO:0045117 azole transmembrane transport 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC19A3 1 GO:0046087 cytidine metabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 APOBEC3A 1 GO:0046322 negative regulation of fatty acid oxidation 1/1165 12/18722 0.537538923708662 0.716676004460028 ACADVL 1 GO:0046541 saliva secretion 1/1165 12/18722 0.537538923708662 0.716676004460028 KCNN4 1 GO:0046606 negative regulation of centrosome cycle 1/1165 12/18722 0.537538923708662 0.716676004460028 NPM1 1 GO:0048548 regulation of pinocytosis 1/1165 12/18722 0.537538923708662 0.716676004460028 CLN3 1 GO:0048934 peripheral nervous system neuron differentiation 1/1165 12/18722 0.537538923708662 0.716676004460028 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/1165 12/18722 0.537538923708662 0.716676004460028 ISL1 1 GO:0051001 negative regulation of nitric-oxide synthase activity 1/1165 12/18722 0.537538923708662 0.716676004460028 ATP2B4 1 GO:0051583 dopamine uptake involved in synaptic transmission 1/1165 12/18722 0.537538923708662 0.716676004460028 PARK7 1 GO:0051639 actin filament network formation 1/1165 12/18722 0.537538923708662 0.716676004460028 LCP1 1 GO:0051934 catecholamine uptake involved in synaptic transmission 1/1165 12/18722 0.537538923708662 0.716676004460028 PARK7 1 GO:0060009 Sertoli cell development 1/1165 12/18722 0.537538923708662 0.716676004460028 FLNA 1 GO:0060123 regulation of growth hormone secretion 1/1165 12/18722 0.537538923708662 0.716676004460028 SERP1 1 GO:0060221 retinal rod cell differentiation 1/1165 12/18722 0.537538923708662 0.716676004460028 PTN 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/1165 12/18722 0.537538923708662 0.716676004460028 LRP1 1 GO:0060442 branching involved in prostate gland morphogenesis 1/1165 12/18722 0.537538923708662 0.716676004460028 BMP7 1 GO:0060601 lateral sprouting from an epithelium 1/1165 12/18722 0.537538923708662 0.716676004460028 BMP7 1 GO:0061430 bone trabecula morphogenesis 1/1165 12/18722 0.537538923708662 0.716676004460028 FBN2 1 GO:0061517 macrophage proliferation 1/1165 12/18722 0.537538923708662 0.716676004460028 TREM2 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/1165 12/18722 0.537538923708662 0.716676004460028 ENO1 1 GO:0070170 regulation of tooth mineralization 1/1165 12/18722 0.537538923708662 0.716676004460028 TFAP2A 1 GO:0070202 regulation of establishment of protein localization to chromosome 1/1165 12/18722 0.537538923708662 0.716676004460028 CCT2 1 GO:0070213 protein auto-ADP-ribosylation 1/1165 12/18722 0.537538923708662 0.716676004460028 PARP1 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/1165 12/18722 0.537538923708662 0.716676004460028 KLF4 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/1165 12/18722 0.537538923708662 0.716676004460028 BRD4 1 GO:0070943 neutrophil-mediated killing of symbiont cell 1/1165 12/18722 0.537538923708662 0.716676004460028 TREM1 1 GO:0071107 response to parathyroid hormone 1/1165 12/18722 0.537538923708662 0.716676004460028 GJA1 1 GO:0071257 cellular response to electrical stimulus 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC9A1 1 GO:0071468 cellular response to acidic pH 1/1165 12/18722 0.537538923708662 0.716676004460028 SLC9A1 1 GO:0071712 ER-associated misfolded protein catabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 VCP 1 GO:0071941 nitrogen cycle metabolic process 1/1165 12/18722 0.537538923708662 0.716676004460028 ASS1 1 GO:0072376 protein activation cascade 1/1165 12/18722 0.537538923708662 0.716676004460028 FBLN1 1 GO:0072537 fibroblast activation 1/1165 12/18722 0.537538923708662 0.716676004460028 GCLM 1 GO:0072584 caveolin-mediated endocytosis 1/1165 12/18722 0.537538923708662 0.716676004460028 CLN3 1 GO:0086067 AV node cell to bundle of His cell communication 1/1165 12/18722 0.537538923708662 0.716676004460028 GJA5 1 GO:0090331 negative regulation of platelet aggregation 1/1165 12/18722 0.537538923708662 0.716676004460028 CD9 1 GO:0090557 establishment of endothelial intestinal barrier 1/1165 12/18722 0.537538923708662 0.716676004460028 TJP1 1 GO:0097152 mesenchymal cell apoptotic process 1/1165 12/18722 0.537538923708662 0.716676004460028 BMP7 1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/1165 12/18722 0.537538923708662 0.716676004460028 JUN 1 GO:0099151 regulation of postsynaptic density assembly 1/1165 12/18722 0.537538923708662 0.716676004460028 ABI3 1 GO:0120263 positive regulation of heterochromatin organization 1/1165 12/18722 0.537538923708662 0.716676004460028 DNMT1 1 GO:0140289 protein mono-ADP-ribosylation 1/1165 12/18722 0.537538923708662 0.716676004460028 PARP9 1 GO:0150065 regulation of deacetylase activity 1/1165 12/18722 0.537538923708662 0.716676004460028 VEGFA 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/1165 12/18722 0.537538923708662 0.716676004460028 NRP1 1 GO:1902950 regulation of dendritic spine maintenance 1/1165 12/18722 0.537538923708662 0.716676004460028 APOE 1 GO:1903405 protein localization to nuclear body 1/1165 12/18722 0.537538923708662 0.716676004460028 CCT2 1 GO:1903441 protein localization to ciliary membrane 1/1165 12/18722 0.537538923708662 0.716676004460028 RABEP1 1 GO:1903909 regulation of receptor clustering 1/1165 12/18722 0.537538923708662 0.716676004460028 PTN 1 GO:1904867 protein localization to Cajal body 1/1165 12/18722 0.537538923708662 0.716676004460028 CCT2 1 GO:1905214 regulation of RNA binding 1/1165 12/18722 0.537538923708662 0.716676004460028 NUCKS1 1 GO:1905709 negative regulation of membrane permeability 1/1165 12/18722 0.537538923708662 0.716676004460028 BNIP3 1 GO:2000303 regulation of ceramide biosynthetic process 1/1165 12/18722 0.537538923708662 0.716676004460028 ORMDL1 1 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/1165 12/18722 0.537538923708662 0.716676004460028 CD55 1 GO:2000727 positive regulation of cardiac muscle cell differentiation 1/1165 12/18722 0.537538923708662 0.716676004460028 TGFB1 1 GO:2001214 positive regulation of vasculogenesis 1/1165 12/18722 0.537538923708662 0.716676004460028 RRAS 1 GO:0008306 associative learning 5/1165 78/18722 0.538728740653805 0.717580546105791 APP/ITGB1/LGMN/FOS/CLN3 5 GO:0043537 negative regulation of blood vessel endothelial cell migration 5/1165 78/18722 0.538728740653805 0.717580546105791 APOE/RHOA/KLF4/ATP2B4/TGFB1 5 GO:1901616 organic hydroxy compound catabolic process 5/1165 78/18722 0.538728740653805 0.717580546105791 APOE/COMT/TPI1/ALDH2/GK 5 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 5/1165 78/18722 0.538728740653805 0.717580546105791 GSTP1/PTPN6/TREM2/LILRB1/TSPO 5 GO:0043271 negative regulation of ion transport 10/1165 160/18722 0.54095214773226 0.720371151891144 GABRE/ANK3/C4orf3/ARL6IP5/GSTO1/LILRB2/LILRB1/YWHAE/ISCU/VDAC1 10 GO:0031644 regulation of nervous system process 9/1165 144/18722 0.543716227275509 0.722292789516657 TYMP/DAG1/APP/PRKCZ/SLC9A1/MGLL/COMT/AKAP9/TNFRSF1B 9 GO:0009311 oligosaccharide metabolic process 4/1165 62/18722 0.544170062144814 0.722292789516657 FBP1/FUT8/ST3GAL4/GAL3ST4 4 GO:0046173 polyol biosynthetic process 4/1165 62/18722 0.544170062144814 0.722292789516657 ISYNA1/AKR1B1/PGP/GCH1 4 GO:0060113 inner ear receptor cell differentiation 4/1165 62/18722 0.544170062144814 0.722292789516657 ESRP1/SOD1/MYO7A/TRIOBP 4 GO:0070265 necrotic cell death 4/1165 62/18722 0.544170062144814 0.722292789516657 HEBP2/TSPO/BNIP3/TMEM123 4 GO:0016236 macroautophagy 18/1165 291/18722 0.545531305314414 0.722292789516657 ATP6V1B1/ATP6V1C2/GAPDH/BNIP3L/EI24/SESN1/VCP/SCOC/SLC25A5/VPS25/VMP1/UFL1/SNX6/CLN3/BNIP3/VDAC1/ATP6V1E1/GABARAPL1 18 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 2/1165 29/18722 0.546374857068897 0.722292789516657 ZFP36/PABPC1 2 GO:0002068 glandular epithelial cell development 2/1165 29/18722 0.546374857068897 0.722292789516657 CDK6/BAD 2 GO:0003209 cardiac atrium morphogenesis 2/1165 29/18722 0.546374857068897 0.722292789516657 ISL1/SOX4 2 GO:0003309 type B pancreatic cell differentiation 2/1165 29/18722 0.546374857068897 0.722292789516657 CDK6/BAD 2 GO:0005979 regulation of glycogen biosynthetic process 2/1165 29/18722 0.546374857068897 0.722292789516657 SORBS1/IGF2 2 GO:0007143 female meiotic nuclear division 2/1165 29/18722 0.546374857068897 0.722292789516657 UBB/TOP2A 2 GO:0010962 regulation of glucan biosynthetic process 2/1165 29/18722 0.546374857068897 0.722292789516657 SORBS1/IGF2 2 GO:0015701 bicarbonate transport 2/1165 29/18722 0.546374857068897 0.722292789516657 SLC26A2/CYB5R1 2 GO:0019433 triglyceride catabolic process 2/1165 29/18722 0.546374857068897 0.722292789516657 MGLL/SORL1 2 GO:0021772 olfactory bulb development 2/1165 29/18722 0.546374857068897 0.722292789516657 DLX5/ATF5 2 GO:0030970 retrograde protein transport, ER to cytosol 2/1165 29/18722 0.546374857068897 0.722292789516657 HSP90B1/VCP 2 GO:0033028 myeloid cell apoptotic process 2/1165 29/18722 0.546374857068897 0.722292789516657 CTSL/IRF7 2 GO:0034311 diol metabolic process 2/1165 29/18722 0.546374857068897 0.722292789516657 PLPP3/GCH1 2 GO:0040018 positive regulation of multicellular organism growth 2/1165 29/18722 0.546374857068897 0.722292789516657 PPIB/IGF2 2 GO:0042759 long-chain fatty acid biosynthetic process 2/1165 29/18722 0.546374857068897 0.722292789516657 GSTP1/GPX4 2 GO:0048753 pigment granule organization 2/1165 29/18722 0.546374857068897 0.722292789516657 TRAPPC6A/ZEB2 2 GO:0050686 negative regulation of mRNA processing 2/1165 29/18722 0.546374857068897 0.722292789516657 NPM1/C1QBP 2 GO:0070198 protein localization to chromosome, telomeric region 2/1165 29/18722 0.546374857068897 0.722292789516657 CCT2/GNL3 2 GO:0070979 protein K11-linked ubiquitination 2/1165 29/18722 0.546374857068897 0.722292789516657 UBE2H/ANAPC11 2 GO:0090114 COPII-coated vesicle budding 2/1165 29/18722 0.546374857068897 0.722292789516657 TFG/PDCD6 2 GO:1902430 negative regulation of amyloid-beta formation 2/1165 29/18722 0.546374857068897 0.722292789516657 APOE/SORL1 2 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 2/1165 29/18722 0.546374857068897 0.722292789516657 SEMA6A/ATP2B4 2 GO:1903513 endoplasmic reticulum to cytosol transport 2/1165 29/18722 0.546374857068897 0.722292789516657 HSP90B1/VCP 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/1165 29/18722 0.546374857068897 0.722292789516657 PRKDC/PARP9 2 GO:0006486 protein glycosylation 14/1165 226/18722 0.546513001439024 0.722292789516657 TUSC3/EXTL2/GALNT11/DDOST/RPN2/FUT8/GFPT1/MAN1A2/SERP1/ST3GAL4/OSTC/C1GALT1/TMEM165/MGAT1 14 GO:0043413 macromolecule glycosylation 14/1165 226/18722 0.546513001439024 0.722292789516657 TUSC3/EXTL2/GALNT11/DDOST/RPN2/FUT8/GFPT1/MAN1A2/SERP1/ST3GAL4/OSTC/C1GALT1/TMEM165/MGAT1 14 GO:0006029 proteoglycan metabolic process 5/1165 79/18722 0.550218363928002 0.726847652795452 CHPF/EXTL2/GPC1/SULF2/GAL3ST4 5 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 5/1165 79/18722 0.550218363928002 0.726847652795452 GAPDH/S100A12/CXCL10/ROMO1/DEFB1 5 GO:0010828 positive regulation of glucose transmembrane transport 3/1165 46/18722 0.552021700992647 0.727859480308134 SORBS1/GPC3/OPN3 3 GO:0031018 endocrine pancreas development 3/1165 46/18722 0.552021700992647 0.727859480308134 CDK6/SOX4/BAD 3 GO:0031057 negative regulation of histone modification 3/1165 46/18722 0.552021700992647 0.727859480308134 DNMT1/SPI1/SET 3 GO:0035094 response to nicotine 3/1165 46/18722 0.552021700992647 0.727859480308134 B2M/HDAC2/BAD 3 GO:0048701 embryonic cranial skeleton morphogenesis 3/1165 46/18722 0.552021700992647 0.727859480308134 TFAP2A/GLI3/SLC39A1 3 GO:0071827 plasma lipoprotein particle organization 3/1165 46/18722 0.552021700992647 0.727859480308134 APOE/PRKACB/APOC1 3 GO:0072599 establishment of protein localization to endoplasmic reticulum 3/1165 46/18722 0.552021700992647 0.727859480308134 HSPA5/SRPRB/SRP14 3 GO:0090329 regulation of DNA-dependent DNA replication 3/1165 46/18722 0.552021700992647 0.727859480308134 STOML2/SSBP1/GMNN 3 GO:0015914 phospholipid transport 6/1165 96/18722 0.555544468376911 0.728692019447522 KCNN4/DBI/APOE/ATP10D/PLSCR1/APOC1 6 GO:0035282 segmentation 6/1165 96/18722 0.555544468376911 0.728692019447522 NRP2/IRX2/TBX3/NRP1/PRKDC/BASP1 6 GO:0042158 lipoprotein biosynthetic process 6/1165 96/18722 0.555544468376911 0.728692019447522 PGAP2/DBI/APOE/GPAA1/NMT1/GLUL 6 GO:0071347 cellular response to interleukin-1 7/1165 113/18722 0.560366583769226 0.728692019447522 GBP2/KLF2/CEBPB/GBP1/CCL3L3/PYCARD/CCL4 7 GO:0006282 regulation of DNA repair 8/1165 130/18722 0.564809473691921 0.728692019447522 EGFR/PARP1/MAGEF1/PRKDC/FUS/BABAM1/RPS3/PARP9 8 GO:0050657 nucleic acid transport 10/1165 163/18722 0.564962277163213 0.728692019447522 IGF2BP3/NPM1/ZFP36/NCBP3/MX2/RAN/LRPPRC/YBX1/ZFP36L1/NUP214 10 GO:0050658 RNA transport 10/1165 163/18722 0.564962277163213 0.728692019447522 IGF2BP3/NPM1/ZFP36/NCBP3/MX2/RAN/LRPPRC/YBX1/ZFP36L1/NUP214 10 GO:0000132 establishment of mitotic spindle orientation 2/1165 30/18722 0.564972553128329 0.728692019447522 GJA1/ITGB1 2 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 2/1165 30/18722 0.564972553128329 0.728692019447522 BLCAP/TOP2A 2 GO:0010453 regulation of cell fate commitment 2/1165 30/18722 0.564972553128329 0.728692019447522 ESRP1/LMO4 2 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/1165 30/18722 0.564972553128329 0.728692019447522 GSTO1/SLC8A1 2 GO:0015721 bile acid and bile salt transport 2/1165 30/18722 0.564972553128329 0.728692019447522 SLCO2B1/AQP9 2 GO:0032480 negative regulation of type I interferon production 2/1165 30/18722 0.564972553128329 0.728692019447522 PYCARD/LILRB1 2 GO:0034368 protein-lipid complex remodeling 2/1165 30/18722 0.564972553128329 0.728692019447522 APOE/APOC1 2 GO:0034369 plasma lipoprotein particle remodeling 2/1165 30/18722 0.564972553128329 0.728692019447522 APOE/APOC1 2 GO:0036258 multivesicular body assembly 2/1165 30/18722 0.564972553128329 0.728692019447522 VPS25/RAB11A 2 GO:0036296 response to increased oxygen levels 2/1165 30/18722 0.564972553128329 0.728692019447522 HDAC2/BNIP3 2 GO:0043032 positive regulation of macrophage activation 2/1165 30/18722 0.564972553128329 0.728692019447522 HSPD1/TREM2 2 GO:0045939 negative regulation of steroid metabolic process 2/1165 30/18722 0.564972553128329 0.728692019447522 SOD1/APOE 2 GO:0048240 sperm capacitation 2/1165 30/18722 0.564972553128329 0.728692019447522 DLD/DEFB1 2 GO:0051968 positive regulation of synaptic transmission, glutamatergic 2/1165 30/18722 0.564972553128329 0.728692019447522 EGFR/GLUL 2 GO:0060218 hematopoietic stem cell differentiation 2/1165 30/18722 0.564972553128329 0.728692019447522 PRKDC/UFL1 2 GO:0060603 mammary gland duct morphogenesis 2/1165 30/18722 0.564972553128329 0.728692019447522 LRP5/TBX3 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/1165 30/18722 0.564972553128329 0.728692019447522 GALNT11/TGFB1 2 GO:0070168 negative regulation of biomineral tissue development 2/1165 30/18722 0.564972553128329 0.728692019447522 SRGN/TGFB1 2 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 2/1165 30/18722 0.564972553128329 0.728692019447522 HSPA5/UFL1 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/1165 30/18722 0.564972553128329 0.728692019447522 ITM2C/CST3 2 GO:0001778 plasma membrane repair 1/1165 13/18722 0.566334602697406 0.728692019447522 SYT7 1 GO:0001886 endothelial cell morphogenesis 1/1165 13/18722 0.566334602697406 0.728692019447522 MET 1 GO:0001973 G protein-coupled adenosine receptor signaling pathway 1/1165 13/18722 0.566334602697406 0.728692019447522 GNAI2 1 GO:0002551 mast cell chemotaxis 1/1165 13/18722 0.566334602697406 0.728692019447522 VEGFA 1 GO:0002638 negative regulation of immunoglobulin production 1/1165 13/18722 0.566334602697406 0.728692019447522 PRKDC 1 GO:0003334 keratinocyte development 1/1165 13/18722 0.566334602697406 0.728692019447522 EXPH5 1 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/1165 13/18722 0.566334602697406 0.728692019447522 STAT1 1 GO:0006995 cellular response to nitrogen starvation 1/1165 13/18722 0.566334602697406 0.728692019447522 GABARAPL1 1 GO:0007567 parturition 1/1165 13/18722 0.566334602697406 0.728692019447522 HPGD 1 GO:0009134 nucleoside diphosphate catabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 NUDT5 1 GO:0009143 nucleoside triphosphate catabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 DUT 1 GO:0009650 UV protection 1/1165 13/18722 0.566334602697406 0.728692019447522 GPX1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/1165 13/18722 0.566334602697406 0.728692019447522 NFKBIA 1 GO:0010755 regulation of plasminogen activation 1/1165 13/18722 0.566334602697406 0.728692019447522 ENO1 1 GO:0014029 neural crest formation 1/1165 13/18722 0.566334602697406 0.728692019447522 PDCD6 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/1165 13/18722 0.566334602697406 0.728692019447522 JAK2 1 GO:0016056 rhodopsin mediated signaling pathway 1/1165 13/18722 0.566334602697406 0.728692019447522 NMT1 1 GO:0018206 peptidyl-methionine modification 1/1165 13/18722 0.566334602697406 0.728692019447522 METAP2 1 GO:0019336 phenol-containing compound catabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 COMT 1 GO:0019755 one-carbon compound transport 1/1165 13/18722 0.566334602697406 0.728692019447522 AQP9 1 GO:0021554 optic nerve development 1/1165 13/18722 0.566334602697406 0.728692019447522 GLI3 1 GO:0021859 pyramidal neuron differentiation 1/1165 13/18722 0.566334602697406 0.728692019447522 UQCRQ 1 GO:0030836 positive regulation of actin filament depolymerization 1/1165 13/18722 0.566334602697406 0.728692019447522 DSTN 1 GO:0031053 primary miRNA processing 1/1165 13/18722 0.566334602697406 0.728692019447522 LIN28B 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/1165 13/18722 0.566334602697406 0.728692019447522 CD74 1 GO:0032042 mitochondrial DNA metabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 PARP1 1 GO:0032352 positive regulation of hormone metabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 GATA3 1 GO:0032494 response to peptidoglycan 1/1165 13/18722 0.566334602697406 0.728692019447522 TREM2 1 GO:0032530 regulation of microvillus organization 1/1165 13/18722 0.566334602697406 0.728692019447522 KLF5 1 GO:0033689 negative regulation of osteoblast proliferation 1/1165 13/18722 0.566334602697406 0.728692019447522 ATRAID 1 GO:0034309 primary alcohol biosynthetic process 1/1165 13/18722 0.566334602697406 0.728692019447522 PARK7 1 GO:0035331 negative regulation of hippo signaling 1/1165 13/18722 0.566334602697406 0.728692019447522 DLG5 1 GO:0035588 G protein-coupled purinergic receptor signaling pathway 1/1165 13/18722 0.566334602697406 0.728692019447522 GNAI2 1 GO:0036302 atrioventricular canal development 1/1165 13/18722 0.566334602697406 0.728692019447522 TBX3 1 GO:0042308 negative regulation of protein import into nucleus 1/1165 13/18722 0.566334602697406 0.728692019447522 FERMT1 1 GO:0042538 hyperosmotic salinity response 1/1165 13/18722 0.566334602697406 0.728692019447522 AKR1B1 1 GO:0043201 response to leucine 1/1165 13/18722 0.566334602697406 0.728692019447522 SESN1 1 GO:0043247 telomere maintenance in response to DNA damage 1/1165 13/18722 0.566334602697406 0.728692019447522 APEX1 1 GO:0043562 cellular response to nitrogen levels 1/1165 13/18722 0.566334602697406 0.728692019447522 GABARAPL1 1 GO:0043970 histone H3-K9 acetylation 1/1165 13/18722 0.566334602697406 0.728692019447522 GATA3 1 GO:0044090 positive regulation of vacuole organization 1/1165 13/18722 0.566334602697406 0.728692019447522 GRN 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/1165 13/18722 0.566334602697406 0.728692019447522 NCF1 1 GO:0048070 regulation of developmental pigmentation 1/1165 13/18722 0.566334602697406 0.728692019447522 ZEB2 1 GO:0048302 regulation of isotype switching to IgG isotypes 1/1165 13/18722 0.566334602697406 0.728692019447522 PTPRC 1 GO:0048711 positive regulation of astrocyte differentiation 1/1165 13/18722 0.566334602697406 0.728692019447522 IL6ST 1 GO:0048820 hair follicle maturation 1/1165 13/18722 0.566334602697406 0.728692019447522 FERMT1 1 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 1/1165 13/18722 0.566334602697406 0.728692019447522 GSTO1 1 GO:0051709 regulation of killing of cells of other organism 1/1165 13/18722 0.566334602697406 0.728692019447522 SYK 1 GO:0051956 negative regulation of amino acid transport 1/1165 13/18722 0.566334602697406 0.728692019447522 ARL6IP5 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/1165 13/18722 0.566334602697406 0.728692019447522 CCNB1 1 GO:0060100 positive regulation of phagocytosis, engulfment 1/1165 13/18722 0.566334602697406 0.728692019447522 TREM2 1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/1165 13/18722 0.566334602697406 0.728692019447522 IRF7 1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1/1165 13/18722 0.566334602697406 0.728692019447522 VEGFA 1 GO:0061469 regulation of type B pancreatic cell proliferation 1/1165 13/18722 0.566334602697406 0.728692019447522 NR4A1 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/1165 13/18722 0.566334602697406 0.728692019447522 ENO1 1 GO:0070234 positive regulation of T cell apoptotic process 1/1165 13/18722 0.566334602697406 0.728692019447522 ADAM8 1 GO:0070316 regulation of G0 to G1 transition 1/1165 13/18722 0.566334602697406 0.728692019447522 FOXO4 1 GO:0070914 UV-damage excision repair 1/1165 13/18722 0.566334602697406 0.728692019447522 DDB1 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/1165 13/18722 0.566334602697406 0.728692019447522 PCM1 1 GO:0072578 neurotransmitter-gated ion channel clustering 1/1165 13/18722 0.566334602697406 0.728692019447522 APOE 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/1165 13/18722 0.566334602697406 0.728692019447522 ORMDL1 1 GO:0099150 regulation of postsynaptic specialization assembly 1/1165 13/18722 0.566334602697406 0.728692019447522 ABI3 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/1165 13/18722 0.566334602697406 0.728692019447522 IARS2 1 GO:0120305 regulation of pigmentation 1/1165 13/18722 0.566334602697406 0.728692019447522 ZEB2 1 GO:1900121 negative regulation of receptor binding 1/1165 13/18722 0.566334602697406 0.728692019447522 B2M 1 GO:1900452 regulation of long-term synaptic depression 1/1165 13/18722 0.566334602697406 0.728692019447522 LILRB2 1 GO:1901096 regulation of autophagosome maturation 1/1165 13/18722 0.566334602697406 0.728692019447522 CLN3 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/1165 13/18722 0.566334602697406 0.728692019447522 ANK3 1 GO:1904590 negative regulation of protein import 1/1165 13/18722 0.566334602697406 0.728692019447522 FERMT1 1 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/1165 13/18722 0.566334602697406 0.728692019447522 KLF4 1 GO:1905038 regulation of membrane lipid metabolic process 1/1165 13/18722 0.566334602697406 0.728692019447522 ORMDL1 1 GO:1905155 positive regulation of membrane invagination 1/1165 13/18722 0.566334602697406 0.728692019447522 TREM2 1 GO:1905269 positive regulation of chromatin organization 1/1165 13/18722 0.566334602697406 0.728692019447522 DNMT1 1 GO:1905939 regulation of gonad development 1/1165 13/18722 0.566334602697406 0.728692019447522 RETN 1 GO:2001023 regulation of response to drug 1/1165 13/18722 0.566334602697406 0.728692019447522 ADIRF 1 GO:0001754 eye photoreceptor cell differentiation 3/1165 47/18722 0.566803733637606 0.728692019447522 MYO7A/PTN/VEGFA 3 GO:0010799 regulation of peptidyl-threonine phosphorylation 3/1165 47/18722 0.566803733637606 0.728692019447522 BMP7/APP/TGFB1 3 GO:0016574 histone ubiquitination 3/1165 47/18722 0.566803733637606 0.728692019447522 DDB1/USP22/PARK7 3 GO:0032008 positive regulation of TOR signaling 3/1165 47/18722 0.566803733637606 0.728692019447522 SLC38A9/TREM2/LAMTOR5 3 GO:0045332 phospholipid translocation 3/1165 47/18722 0.566803733637606 0.728692019447522 KCNN4/ATP10D/PLSCR1 3 GO:0045747 positive regulation of Notch signaling pathway 3/1165 47/18722 0.566803733637606 0.728692019447522 AAK1/YAP1/IL6ST 3 GO:0061001 regulation of dendritic spine morphogenesis 3/1165 47/18722 0.566803733637606 0.728692019447522 EFNA1/DHX36/ABI3 3 GO:0007041 lysosomal transport 7/1165 114/18722 0.569832156157162 0.732417653425727 LAPTM5/VCP/CLN3/HSPA8/LRP1/SORL1/GRN 7 GO:0001960 negative regulation of cytokine-mediated signaling pathway 5/1165 81/18722 0.572771055520587 0.735689687559967 ISG15/PTPRC/GSTP1/TREM2/OAS1 5 GO:0008589 regulation of smoothened signaling pathway 5/1165 81/18722 0.572771055520587 0.735689687559967 DLG5/GLI3/GPC3/VCP/PRKACB 5 GO:0030641 regulation of cellular pH 5/1165 81/18722 0.572771055520587 0.735689687559967 SLC9A1/SLC11A1/TMEM165/CLN3/GRN 5 GO:0050853 B cell receptor signaling pathway 8/1165 131/18722 0.573623283639701 0.736615760940207 SLC39A10/PTPRC/VAV3/PTPN6/MNDA/SYK/CD300A/LYN 8 GO:0043473 pigmentation 6/1165 98/18722 0.575993714858241 0.739490558439915 GLI3/MYO7A/GNA11/TRAPPC6A/RAB11A/ZEB2 6 GO:0070507 regulation of microtubule cytoskeleton organization 9/1165 148/18722 0.577230676855788 0.740909167434608 MET/GNAI1/RHOA/CLIP1/CLTC/AKAP9/CIB1/STMN1/RPS3 9 GO:0021700 developmental maturation 17/1165 280/18722 0.577748666980653 0.741404496516324 DAG1/FERMT1/TFCP2L1/APP/GATA3/EPAS1/KLF2/SNX10/C1QA/AKR1B1/RHOA/VEGFA/FAM210B/DLD/TYMS/DEFB1/CCNB1 17 GO:0000077 DNA damage checkpoint signaling 7/1165 115/18722 0.579201813548308 0.742929565687077 FOXO4/PRKDC/SOX4/EIF2AK4/CCND1/MDM2/BABAM1 7 GO:0042471 ear morphogenesis 7/1165 115/18722 0.579201813548308 0.742929565687077 GATA3/ATP6V1B1/TFAP2A/SOD1/MYO7A/DLX5/TRIOBP 7 GO:0010569 regulation of double-strand break repair via homologous recombination 3/1165 48/18722 0.581282095883536 0.744079234917908 PARP1/MAGEF1/FUS 3 GO:0032527 protein exit from endoplasmic reticulum 3/1165 48/18722 0.581282095883536 0.744079234917908 HSP90B1/VCP/SORL1 3 GO:1902003 regulation of amyloid-beta formation 3/1165 48/18722 0.581282095883536 0.744079234917908 EFNA1/APOE/SORL1 3 GO:0033692 cellular polysaccharide biosynthetic process 4/1165 65/18722 0.582056183967131 0.744079234917908 SORBS1/AGL/IGF2/UGP2 4 GO:0045682 regulation of epidermis development 4/1165 65/18722 0.582056183967131 0.744079234917908 ESRP1/ZFP36/NCOA3/ZFP36L1 4 GO:0090307 mitotic spindle assembly 4/1165 65/18722 0.582056183967131 0.744079234917908 RHOA/FLNA/RAB11A/SMC3 4 GO:0001516 prostaglandin biosynthetic process 2/1165 31/18722 0.583014515440755 0.744079234917908 PTGES/CD74 2 GO:0002063 chondrocyte development 2/1165 31/18722 0.583014515440755 0.744079234917908 SERPINH1/SULF2 2 GO:0006613 cotranslational protein targeting to membrane 2/1165 31/18722 0.583014515440755 0.744079234917908 SIL1/SRP14 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/1165 31/18722 0.583014515440755 0.744079234917908 TSPO/UROD 2 GO:0008045 motor neuron axon guidance 2/1165 31/18722 0.583014515440755 0.744079234917908 NRP1/RHOG 2 GO:0018200 peptidyl-glutamic acid modification 2/1165 31/18722 0.583014515440755 0.744079234917908 PARP1/NAA10 2 GO:0021988 olfactory lobe development 2/1165 31/18722 0.583014515440755 0.744079234917908 DLX5/ATF5 2 GO:0032509 endosome transport via multivesicular body sorting pathway 2/1165 31/18722 0.583014515440755 0.744079234917908 VCP/VPS25 2 GO:0033014 tetrapyrrole biosynthetic process 2/1165 31/18722 0.583014515440755 0.744079234917908 TSPO/UROD 2 GO:0035115 embryonic forelimb morphogenesis 2/1165 31/18722 0.583014515440755 0.744079234917908 TFAP2A/TBX3 2 GO:0036257 multivesicular body organization 2/1165 31/18722 0.583014515440755 0.744079234917908 VPS25/RAB11A 2 GO:0046457 prostanoid biosynthetic process 2/1165 31/18722 0.583014515440755 0.744079234917908 PTGES/CD74 2 GO:0048710 regulation of astrocyte differentiation 2/1165 31/18722 0.583014515440755 0.744079234917908 IL6ST/TREM2 2 GO:0060795 cell fate commitment involved in formation of primary germ layer 2/1165 31/18722 0.583014515440755 0.744079234917908 KLF4/RTF1 2 GO:0070633 transepithelial transport 2/1165 31/18722 0.583014515440755 0.744079234917908 SLC1A3/ACTB 2 GO:0110150 negative regulation of biomineralization 2/1165 31/18722 0.583014515440755 0.744079234917908 SRGN/TGFB1 2 GO:0003300 cardiac muscle hypertrophy 6/1165 99/18722 0.586040327195811 0.744558525047062 PARP1/SLC9A1/ATP2B4/IL6ST/HDAC2/TNFRSF1B 6 GO:0019216 regulation of lipid metabolic process 20/1165 331/18722 0.587469767670262 0.744558525047062 SORBS1/SOD1/FLT1/APOE/IDH1/ORMDL1/VAV3/APOC1/CD74/TGFB1/STOML2/TREM2/FGR/SF1/LACTB/TSPO/CGA/SORL1/ACADVL/LYN 20 GO:0051236 establishment of RNA localization 10/1165 166/18722 0.588441565927175 0.744558525047062 IGF2BP3/NPM1/ZFP36/NCBP3/MX2/RAN/LRPPRC/YBX1/ZFP36L1/NUP214 10 GO:0031123 RNA 3'-end processing 7/1165 116/18722 0.588472016416165 0.744558525047062 LIN28B/APP/RPS21/DHX36/PABPC1/ZFP36L1/CCNB1 7 GO:0010565 regulation of cellular ketone metabolic process 8/1165 133/18722 0.591002135862923 0.744558525047062 COMT/APOC1/ATP2B4/CD74/PARK7/CLN3/ACADVL/SLC7A7 8 GO:0000212 meiotic spindle organization 1/1165 14/18722 0.593338728404687 0.744558525047062 ASPM 1 GO:0001711 endodermal cell fate commitment 1/1165 14/18722 0.593338728404687 0.744558525047062 RTF1 1 GO:0001921 positive regulation of receptor recycling 1/1165 14/18722 0.593338728404687 0.744558525047062 NSG1 1 GO:0002091 negative regulation of receptor internalization 1/1165 14/18722 0.593338728404687 0.744558525047062 LRPAP1 1 GO:0002467 germinal center formation 1/1165 14/18722 0.593338728404687 0.744558525047062 TNFSF13B 1 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1/1165 14/18722 0.593338728404687 0.744558525047062 IRF7 1 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/1165 14/18722 0.593338728404687 0.744558525047062 S1PR4 1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 1/1165 14/18722 0.593338728404687 0.744558525047062 SERPINH1 1 GO:0006241 CTP biosynthetic process 1/1165 14/18722 0.593338728404687 0.744558525047062 NME1 1 GO:0006287 base-excision repair, gap-filling 1/1165 14/18722 0.593338728404687 0.744558525047062 APEX1 1 GO:0007100 mitotic centrosome separation 1/1165 14/18722 0.593338728404687 0.744558525047062 RANBP1 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/1165 14/18722 0.593338728404687 0.744558525047062 PRLR 1 GO:0007638 mechanosensory behavior 1/1165 14/18722 0.593338728404687 0.744558525047062 SLC1A3 1 GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 1/1165 14/18722 0.593338728404687 0.744558525047062 UPP1 1 GO:0010896 regulation of triglyceride catabolic process 1/1165 14/18722 0.593338728404687 0.744558525047062 SORL1 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/1165 14/18722 0.593338728404687 0.744558525047062 MYLIP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/1165 14/18722 0.593338728404687 0.744558525047062 DAG1 1 GO:0022038 corpus callosum development 1/1165 14/18722 0.593338728404687 0.744558525047062 C12orf57 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/1165 14/18722 0.593338728404687 0.744558525047062 PDCD6 1 GO:0031054 pre-miRNA processing 1/1165 14/18722 0.593338728404687 0.744558525047062 LIN28B 1 GO:0031115 negative regulation of microtubule polymerization 1/1165 14/18722 0.593338728404687 0.744558525047062 STMN1 1 GO:0031650 regulation of heat generation 1/1165 14/18722 0.593338728404687 0.744558525047062 PTGES 1 GO:0033212 iron import into cell 1/1165 14/18722 0.593338728404687 0.744558525047062 ISCU 1 GO:0034111 negative regulation of homotypic cell-cell adhesion 1/1165 14/18722 0.593338728404687 0.744558525047062 CD9 1 GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 1/1165 14/18722 0.593338728404687 0.744558525047062 GPR34 1 GO:0035630 bone mineralization involved in bone maturation 1/1165 14/18722 0.593338728404687 0.744558525047062 SNX10 1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1/1165 14/18722 0.593338728404687 0.744558525047062 LRP1 1 GO:0035810 positive regulation of urine volume 1/1165 14/18722 0.593338728404687 0.744558525047062 GNAI2 1 GO:0035815 positive regulation of renal sodium excretion 1/1165 14/18722 0.593338728404687 0.744558525047062 GNAI2 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/1165 14/18722 0.593338728404687 0.744558525047062 DBI 1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1/1165 14/18722 0.593338728404687 0.744558525047062 PMAIP1 1 GO:0043650 dicarboxylic acid biosynthetic process 1/1165 14/18722 0.593338728404687 0.744558525047062 KYNU 1 GO:0044154 histone H3-K14 acetylation 1/1165 14/18722 0.593338728404687 0.744558525047062 GATA3 1 GO:0044764 multi-organism cellular process 1/1165 14/18722 0.593338728404687 0.744558525047062 CTSL 1 GO:0045006 DNA deamination 1/1165 14/18722 0.593338728404687 0.744558525047062 APOBEC3A 1 GO:0045023 G0 to G1 transition 1/1165 14/18722 0.593338728404687 0.744558525047062 FOXO4 1 GO:0045472 response to ether 1/1165 14/18722 0.593338728404687 0.744558525047062 MDM2 1 GO:0045820 negative regulation of glycolytic process 1/1165 14/18722 0.593338728404687 0.744558525047062 FBP1 1 GO:0045989 positive regulation of striated muscle contraction 1/1165 14/18722 0.593338728404687 0.744558525047062 GSTO1 1 GO:0046049 UMP metabolic process 1/1165 14/18722 0.593338728404687 0.744558525047062 UPP1 1 GO:0046325 negative regulation of glucose import 1/1165 14/18722 0.593338728404687 0.744558525047062 PEA15 1 GO:0046462 monoacylglycerol metabolic process 1/1165 14/18722 0.593338728404687 0.744558525047062 MGLL 1 GO:0048172 regulation of short-term neuronal synaptic plasticity 1/1165 14/18722 0.593338728404687 0.744558525047062 CLN3 1 GO:0048368 lateral mesoderm development 1/1165 14/18722 0.593338728404687 0.744558525047062 YAP1 1 GO:0050667 homocysteine metabolic process 1/1165 14/18722 0.593338728404687 0.744558525047062 COMT 1 GO:0050930 induction of positive chemotaxis 1/1165 14/18722 0.593338728404687 0.744558525047062 VEGFA 1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 1/1165 14/18722 0.593338728404687 0.744558525047062 CXCR4 1 GO:0051589 negative regulation of neurotransmitter transport 1/1165 14/18722 0.593338728404687 0.744558525047062 PNKD 1 GO:0051984 positive regulation of chromosome segregation 1/1165 14/18722 0.593338728404687 0.744558525047062 CCNB1 1 GO:0055057 neuroblast division 1/1165 14/18722 0.593338728404687 0.744558525047062 ASPM 1 GO:0060841 venous blood vessel development 1/1165 14/18722 0.593338728404687 0.744558525047062 VEGFA 1 GO:0061043 regulation of vascular wound healing 1/1165 14/18722 0.593338728404687 0.744558525047062 CXCR4 1 GO:0061709 reticulophagy 1/1165 14/18722 0.593338728404687 0.744558525047062 UFL1 1 GO:0070278 extracellular matrix constituent secretion 1/1165 14/18722 0.593338728404687 0.744558525047062 TNFRSF1B 1 GO:0070307 lens fiber cell development 1/1165 14/18722 0.593338728404687 0.744558525047062 VIM 1 GO:0070942 neutrophil mediated cytotoxicity 1/1165 14/18722 0.593338728404687 0.744558525047062 TREM1 1 GO:0070986 left/right axis specification 1/1165 14/18722 0.593338728404687 0.744558525047062 HSPB11 1 GO:0071415 cellular response to purine-containing compound 1/1165 14/18722 0.593338728404687 0.744558525047062 SLC8A1 1 GO:0072498 embryonic skeletal joint development 1/1165 14/18722 0.593338728404687 0.744558525047062 BMP7 1 GO:0090239 regulation of histone H4 acetylation 1/1165 14/18722 0.593338728404687 0.744558525047062 SPI1 1 GO:0090281 negative regulation of calcium ion import 1/1165 14/18722 0.593338728404687 0.744558525047062 VDAC1 1 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 1/1165 14/18722 0.593338728404687 0.744558525047062 DNMT1 1 GO:0097531 mast cell migration 1/1165 14/18722 0.593338728404687 0.744558525047062 VEGFA 1 GO:1900037 regulation of cellular response to hypoxia 1/1165 14/18722 0.593338728404687 0.744558525047062 ENO1 1 GO:1901678 iron coordination entity transport 1/1165 14/18722 0.593338728404687 0.744558525047062 PGRMC2 1 GO:1902036 regulation of hematopoietic stem cell differentiation 1/1165 14/18722 0.593338728404687 0.744558525047062 PRKDC 1 GO:1902916 positive regulation of protein polyubiquitination 1/1165 14/18722 0.593338728404687 0.744558525047062 SKP2 1 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 1/1165 14/18722 0.593338728404687 0.744558525047062 SOD2 1 GO:1905208 negative regulation of cardiocyte differentiation 1/1165 14/18722 0.593338728404687 0.744558525047062 EGFR 1 GO:1990173 protein localization to nucleoplasm 1/1165 14/18722 0.593338728404687 0.744558525047062 CCT2 1 GO:0030193 regulation of blood coagulation 4/1165 66/18722 0.594274275926316 0.745232687840574 PRDX2/APOE/CD9/ST3GAL4 4 GO:1905953 negative regulation of lipid localization 4/1165 66/18722 0.594274275926316 0.745232687840574 NFKBIA/APOC1/TREM2/FIS1 4 GO:2000272 negative regulation of signaling receptor activity 4/1165 66/18722 0.594274275926316 0.745232687840574 LRPAP1/VPS25/LILRB4/SNX6 4 GO:0046785 microtubule polymerization 5/1165 83/18722 0.594718630121001 0.745623335016569 MET/CLIP1/AKAP9/STMN1/RPS3 5 GO:0007602 phototransduction 3/1165 49/18722 0.595449857411115 0.745873699988527 GNA11/OPN3/NMT1 3 GO:0032692 negative regulation of interleukin-1 production 3/1165 49/18722 0.595449857411115 0.745873699988527 GSTP1/TREM2/LILRB4 3 GO:0042304 regulation of fatty acid biosynthetic process 3/1165 49/18722 0.595449857411115 0.745873699988527 APOC1/CD74/ACADVL 3 GO:1901799 negative regulation of proteasomal protein catabolic process 3/1165 49/18722 0.595449857411115 0.745873699988527 HSP90AB1/USP14/PARK7 3 GO:0006664 glycolipid metabolic process 6/1165 100/18722 0.595962826226677 0.746183212940071 ITGB8/PGAP2/GPAA1/FUCA1/ST3GAL4/GAL3ST4 6 GO:0061640 cytoskeleton-dependent cytokinesis 6/1165 100/18722 0.595962826226677 0.746183212940071 MYH10/ANK3/RASA1/RHOA/STMN1/SON 6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 10/1165 167/18722 0.59613915817694 0.746237532303114 TENM3/CDH1/DSG2/DSC3/CADM1/DSC2/OBSL1/ITGB1/BSG/PECAM1 10 GO:0051225 spindle assembly 7/1165 117/18722 0.597639437462187 0.747948754175085 ASPM/TUBB/RHOA/FLNA/RAB11A/RPS3/SMC3 7 GO:0008277 regulation of G protein-coupled receptor signaling pathway 8/1165 134/18722 0.599561401937144 0.749687362077575 MET/MGLL/ATP2B4/NMT1/STMN1/PHB/RGS10/GNAI2 8 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 8/1165 134/18722 0.599561401937144 0.749687362077575 HSP90AB1/VCP/DAB2/MDM2/USP14/PARK7/RAD23B/UFL1 8 GO:0006308 DNA catabolic process 2/1165 32/18722 0.600497840709207 0.749687362077575 ISG20/APEX1 2 GO:0006506 GPI anchor biosynthetic process 2/1165 32/18722 0.600497840709207 0.749687362077575 PGAP2/GPAA1 2 GO:0032196 transposition 2/1165 32/18722 0.600497840709207 0.749687362077575 L1TD1/APOBEC3A 2 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 2/1165 32/18722 0.600497840709207 0.749687362077575 BRD4/EAPP 2 GO:0034367 protein-containing complex remodeling 2/1165 32/18722 0.600497840709207 0.749687362077575 APOE/APOC1 2 GO:0035883 enteroendocrine cell differentiation 2/1165 32/18722 0.600497840709207 0.749687362077575 CDK6/BAD 2 GO:0045761 regulation of adenylate cyclase activity 2/1165 32/18722 0.600497840709207 0.749687362077575 AKAP9/GNAI2 2 GO:0090140 regulation of mitochondrial fission 2/1165 32/18722 0.600497840709207 0.749687362077575 FIS1/BNIP3 2 GO:1901889 negative regulation of cell junction assembly 2/1165 32/18722 0.600497840709207 0.749687362077575 TLR2/LRP1 2 GO:1903509 liposaccharide metabolic process 6/1165 101/18722 0.605757500357218 0.756085579165014 ITGB8/PGAP2/GPAA1/FUCA1/ST3GAL4/GAL3ST4 6 GO:0042490 mechanoreceptor differentiation 4/1165 67/18722 0.606277618178447 0.756230282407916 ESRP1/SOD1/MYO7A/TRIOBP 4 GO:0050435 amyloid-beta metabolic process 4/1165 67/18722 0.606277618178447 0.756230282407916 MME/EFNA1/APOE/SORL1 4 GO:1902117 positive regulation of organelle assembly 4/1165 67/18722 0.606277618178447 0.756230282407916 LCP1/RHOA/ATMIN/MSN 4 GO:0022412 cellular process involved in reproduction in multicellular organism 23/1165 384/18722 0.606443433187389 0.756269049207024 LGR5/JAM3/SPESP1/FOLR1/PRDX4/ASPM/ITGB1/SLIRP/PTN/SMARCA2/UBB/ETV5/PITHD1/DNMT3A/CD9/CIB1/DLD/EIF2S2/CDYL/RETN/DEFB1/TOP2A/CCNB1 23 GO:0030203 glycosaminoglycan metabolic process 7/1165 118/18722 0.606700959436966 0.756422142452174 ITIH5/CHPF/CD44/FUCA1/CLTC/TGFB1/ST3GAL4 7 GO:0051646 mitochondrion localization 3/1165 50/18722 0.609301341615025 0.756547623382497 UBB/ARMCX3/LRPPRC 3 GO:0071825 protein-lipid complex subunit organization 3/1165 50/18722 0.609301341615025 0.756547623382497 APOE/PRKACB/APOC1 3 GO:1903747 regulation of establishment of protein localization to mitochondrion 3/1165 50/18722 0.609301341615025 0.756547623382497 LMAN1/BNIP3L/NMT1 3 GO:0050871 positive regulation of B cell activation 9/1165 152/18722 0.609601756754367 0.756547623382497 SLC39A10/TFRC/PTPRC/VAV3/CD74/TNFSF13B/TGFB1/BAD/SYK 9 GO:0000075 cell cycle checkpoint signaling 10/1165 169/18722 0.611328418524436 0.756547623382497 DUSP1/FOXO4/PRKDC/SOX4/EIF2AK4/CCND1/MDM2/CENPF/BABAM1/CCNB1 10 GO:0006643 membrane lipid metabolic process 12/1165 203/18722 0.615045912369573 0.756547623382497 HACD3/PLPP3/ITGB8/PGAP2/DEGS1/ORMDL1/GPAA1/FUCA1/SERINC2/TECR/ST3GAL4/GAL3ST4 12 GO:0010522 regulation of calcium ion transport into cytosol 6/1165 102/18722 0.615420926152478 0.756547623382497 CYBA/PTPN6/GSTO1/CXCL10/SLC8A1/LYN 6 GO:0014897 striated muscle hypertrophy 6/1165 102/18722 0.615420926152478 0.756547623382497 PARP1/SLC9A1/ATP2B4/IL6ST/HDAC2/TNFRSF1B 6 GO:0045833 negative regulation of lipid metabolic process 6/1165 102/18722 0.615420926152478 0.756547623382497 SOD1/APOE/ORMDL1/APOC1/SORL1/ACADVL 6 GO:1904063 negative regulation of cation transmembrane transport 6/1165 102/18722 0.615420926152478 0.756547623382497 ANK3/C4orf3/GSTO1/YWHAE/ISCU/VDAC1 6 GO:0031398 positive regulation of protein ubiquitination 7/1165 119/18722 0.61565367259192 0.756547623382497 LAPTM5/NDFIP2/NPM1/SKP2/HSPA5/UBB/PDCD6 7 GO:0072384 organelle transport along microtubule 5/1165 85/18722 0.616023639855619 0.756547623382497 PRKCZ/UBB/ARMCX3/LRPPRC/CLN3 5 GO:2000779 regulation of double-strand break repair 5/1165 85/18722 0.616023639855619 0.756547623382497 PARP1/MAGEF1/PRKDC/FUS/PARP9 5 GO:0001881 receptor recycling 2/1165 33/18722 0.617422136508866 0.756547623382497 NSG1/SORL1 2 GO:0002335 mature B cell differentiation 2/1165 33/18722 0.617422136508866 0.756547623382497 SPI1/DOCK10 2 GO:0006505 GPI anchor metabolic process 2/1165 33/18722 0.617422136508866 0.756547623382497 PGAP2/GPAA1 2 GO:0006536 glutamate metabolic process 2/1165 33/18722 0.617422136508866 0.756547623382497 GCLM/GLUL 2 GO:0010737 protein kinase A signaling 2/1165 33/18722 0.617422136508866 0.756547623382497 LCP1/PRKACB 2 GO:0035025 positive regulation of Rho protein signal transduction 2/1165 33/18722 0.617422136508866 0.756547623382497 ADGRG1/NET1 2 GO:0050901 leukocyte tethering or rolling 2/1165 33/18722 0.617422136508866 0.756547623382497 ITGB1/ST3GAL4 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/1165 33/18722 0.617422136508866 0.756547623382497 DHX36/PSMC6 2 GO:1901099 negative regulation of signal transduction in absence of ligand 2/1165 33/18722 0.617422136508866 0.756547623382497 PRDX2/IFI6 2 GO:1901976 regulation of cell cycle checkpoint 2/1165 33/18722 0.617422136508866 0.756547623382497 DUSP1/CCNB1 2 GO:1902992 negative regulation of amyloid precursor protein catabolic process 2/1165 33/18722 0.617422136508866 0.756547623382497 APOE/SORL1 2 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/1165 33/18722 0.617422136508866 0.756547623382497 PRDX2/IFI6 2 GO:0007585 respiratory gaseous exchange by respiratory system 4/1165 68/18722 0.618061568063731 0.756547623382497 ADH5/SLC5A3/FUT8/MAN1A2 4 GO:0009247 glycolipid biosynthetic process 4/1165 68/18722 0.618061568063731 0.756547623382497 PGAP2/GPAA1/ST3GAL4/GAL3ST4 4 GO:1900046 regulation of hemostasis 4/1165 68/18722 0.618061568063731 0.756547623382497 PRDX2/APOE/CD9/ST3GAL4 4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/1165 15/18722 0.618662674385473 0.756547623382497 RPL35 1 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/1165 15/18722 0.618662674385473 0.756547623382497 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/1165 15/18722 0.618662674385473 0.756547623382497 RPS21 1 GO:0000722 telomere maintenance via recombination 1/1165 15/18722 0.618662674385473 0.756547623382497 RAD50 1 GO:0003356 regulation of cilium beat frequency 1/1165 15/18722 0.618662674385473 0.756547623382497 CATSPER1 1 GO:0006098 pentose-phosphate shunt 1/1165 15/18722 0.618662674385473 0.756547623382497 RPIA 1 GO:0006570 tyrosine metabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 IL4I1 1 GO:0009083 branched-chain amino acid catabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 ECHS1 1 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 1/1165 15/18722 0.618662674385473 0.756547623382497 NME1 1 GO:0010273 detoxification of copper ion 1/1165 15/18722 0.618662674385473 0.756547623382497 PARK7 1 GO:0010713 negative regulation of collagen metabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 CST3 1 GO:0010832 negative regulation of myotube differentiation 1/1165 15/18722 0.618662674385473 0.756547623382497 BHLHE41 1 GO:0014733 regulation of skeletal muscle adaptation 1/1165 15/18722 0.618662674385473 0.756547623382497 CAMK2G 1 GO:0014744 positive regulation of muscle adaptation 1/1165 15/18722 0.618662674385473 0.756547623382497 AIF1 1 GO:0014841 skeletal muscle satellite cell proliferation 1/1165 15/18722 0.618662674385473 0.756547623382497 JAK2 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/1165 15/18722 0.618662674385473 0.756547623382497 JAK2 1 GO:0016114 terpenoid biosynthetic process 1/1165 15/18722 0.618662674385473 0.756547623382497 FDPS 1 GO:0018146 keratan sulfate biosynthetic process 1/1165 15/18722 0.618662674385473 0.756547623382497 ST3GAL4 1 GO:0018216 peptidyl-arginine methylation 1/1165 15/18722 0.618662674385473 0.756547623382497 PRMT1 1 GO:0018298 protein-chromophore linkage 1/1165 15/18722 0.618662674385473 0.756547623382497 OPN3 1 GO:0021542 dentate gyrus development 1/1165 15/18722 0.618662674385473 0.756547623382497 CDK6 1 GO:0030252 growth hormone secretion 1/1165 15/18722 0.618662674385473 0.756547623382497 SERP1 1 GO:0032310 prostaglandin secretion 1/1165 15/18722 0.618662674385473 0.756547623382497 PTGES 1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/1165 15/18722 0.618662674385473 0.756547623382497 ISL1 1 GO:0034310 primary alcohol catabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 ALDH2 1 GO:0034638 phosphatidylcholine catabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 APOC1 1 GO:0035435 phosphate ion transmembrane transport 1/1165 15/18722 0.618662674385473 0.756547623382497 SLC25A3 1 GO:0043252 sodium-independent organic anion transport 1/1165 15/18722 0.618662674385473 0.756547623382497 SLCO2B1 1 GO:0043981 histone H4-K5 acetylation 1/1165 15/18722 0.618662674385473 0.756547623382497 PHF20 1 GO:0043982 histone H4-K8 acetylation 1/1165 15/18722 0.618662674385473 0.756547623382497 PHF20 1 GO:0044406 adhesion of symbiont to host 1/1165 15/18722 0.618662674385473 0.756547623382497 HSP90AB1 1 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 1/1165 15/18722 0.618662674385473 0.756547623382497 ANAPC11 1 GO:0045986 negative regulation of smooth muscle contraction 1/1165 15/18722 0.618662674385473 0.756547623382497 SOD1 1 GO:0046007 negative regulation of activated T cell proliferation 1/1165 15/18722 0.618662674385473 0.756547623382497 LILRB4 1 GO:0046184 aldehyde biosynthetic process 1/1165 15/18722 0.618662674385473 0.756547623382497 TPI1 1 GO:0048712 negative regulation of astrocyte differentiation 1/1165 15/18722 0.618662674385473 0.756547623382497 TREM2 1 GO:0050746 regulation of lipoprotein metabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 DBI 1 GO:0051284 positive regulation of sequestering of calcium ion 1/1165 15/18722 0.618662674385473 0.756547623382497 GSTO1 1 GO:0051299 centrosome separation 1/1165 15/18722 0.618662674385473 0.756547623382497 RANBP1 1 GO:0051608 histamine transport 1/1165 15/18722 0.618662674385473 0.756547623382497 LYN 1 GO:0055012 ventricular cardiac muscle cell differentiation 1/1165 15/18722 0.618662674385473 0.756547623382497 CCNB1 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/1165 15/18722 0.618662674385473 0.756547623382497 SORL1 1 GO:0070071 proton-transporting two-sector ATPase complex assembly 1/1165 15/18722 0.618662674385473 0.756547623382497 ATP6V1B1 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/1165 15/18722 0.618662674385473 0.756547623382497 SORL1 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/1165 15/18722 0.618662674385473 0.756547623382497 ATP2B4 1 GO:0071599 otic vesicle development 1/1165 15/18722 0.618662674385473 0.756547623382497 GATA3 1 GO:0072224 metanephric glomerulus development 1/1165 15/18722 0.618662674385473 0.756547623382497 LGR4 1 GO:0080154 regulation of fertilization 1/1165 15/18722 0.618662674385473 0.756547623382497 LHFPL2 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/1165 15/18722 0.618662674385473 0.756547623382497 CDH1 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/1165 15/18722 0.618662674385473 0.756547623382497 ATP2B4 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1165 15/18722 0.618662674385473 0.756547623382497 NCL 1 GO:1901970 positive regulation of mitotic sister chromatid separation 1/1165 15/18722 0.618662674385473 0.756547623382497 ANAPC11 1 GO:1902018 negative regulation of cilium assembly 1/1165 15/18722 0.618662674385473 0.756547623382497 YAP1 1 GO:1903727 positive regulation of phospholipid metabolic process 1/1165 15/18722 0.618662674385473 0.756547623382497 STOML2 1 GO:1903729 regulation of plasma membrane organization 1/1165 15/18722 0.618662674385473 0.756547623382497 WASL 1 GO:1904889 regulation of excitatory synapse assembly 1/1165 15/18722 0.618662674385473 0.756547623382497 ABI3 1 GO:1990169 stress response to copper ion 1/1165 15/18722 0.618662674385473 0.756547623382497 PARK7 1 GO:2000104 negative regulation of DNA-dependent DNA replication 1/1165 15/18722 0.618662674385473 0.756547623382497 GMNN 1 GO:2000402 negative regulation of lymphocyte migration 1/1165 15/18722 0.618662674385473 0.756547623382497 WASL 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/1165 15/18722 0.618662674385473 0.756547623382497 CD74 1 GO:0006636 unsaturated fatty acid biosynthetic process 3/1165 51/18722 0.622832045365431 0.760817469126477 PTGES/DEGS1/CD74 3 GO:0009584 detection of visible light 3/1165 51/18722 0.622832045365431 0.760817469126477 GNA11/OPN3/NMT1 3 GO:0010656 negative regulation of muscle cell apoptotic process 3/1165 51/18722 0.622832045365431 0.760817469126477 BMP7/DNMT1/JAK2 3 GO:0045668 negative regulation of osteoblast differentiation 3/1165 51/18722 0.622832045365431 0.760817469126477 CRIM1/LRP5/CDK6 3 GO:0065002 intracellular protein transmembrane transport 3/1165 51/18722 0.622832045365431 0.760817469126477 HSPD1/HSPA5/ROMO1 3 GO:0050773 regulation of dendrite development 6/1165 103/18722 0.624949962626243 0.763238498742625 BMP7/OBSL1/PTN/ID1/RHOA/DHX36 6 GO:0050770 regulation of axonogenesis 9/1165 154/18722 0.625310402222476 0.763346517545619 SEMA6A/SEMA6D/EFNA1/NRP1/GOLGA4/VEGFA/SKIL/RAB11A/LRP1 9 GO:0051168 nuclear export 9/1165 154/18722 0.625310402222476 0.763346517545619 PTPN14/NPM1/RAN/TGFB1/MDM2/PARK7/CALR/YWHAE/NUP214 9 GO:0009798 axis specification 5/1165 86/18722 0.626425341717653 0.764208963934185 WLS/GPC3/TBX3/HSPB11/BASP1 5 GO:0022406 membrane docking 5/1165 86/18722 0.626425341717653 0.764208963934185 STXBP2/MSN/VMP1/CLN3/SNX3 5 GO:0045921 positive regulation of exocytosis 5/1165 86/18722 0.626425341717653 0.764208963934185 EXPH5/SYT7/HLA-F/FGR/SYK 5 GO:0006368 transcription elongation from RNA polymerase II promoter 4/1165 69/18722 0.629622125257768 0.767608381640281 BRD4/RTF1/POLR2I/EAPP 4 GO:0019226 transmission of nerve impulse 4/1165 69/18722 0.629622125257768 0.767608381640281 TYMP/JAM3/ANK3/SOD1 4 GO:0031060 regulation of histone methylation 4/1165 69/18722 0.629622125257768 0.767608381640281 GATA3/BRD4/DNMT1/RTF1 4 GO:0000280 nuclear division 26/1165 439/18722 0.632618403079063 0.770012747810788 BMP7/LRP5/ASPM/OBSL1/DUSP1/RHOA/AURKAIP1/CCNE1/UBB/FLNA/EPS8/RAN/RAD50/ANAPC11/CKS2/RANBP1/MKI67/CENPF/CALR/IGF2/NAA10/RAD21/RAB11A/TOP2A/SMC3/CCNB1 26 GO:0007219 Notch signaling pathway 10/1165 172/18722 0.633569100053496 0.770012747810788 BMP7/APP/AAK1/PERP/GALNT11/YAP1/NFKBIA/CD46/IL6ST/KRT19 10 GO:0007095 mitotic G2 DNA damage checkpoint signaling 2/1165 34/18722 0.633789220539077 0.770012747810788 FOXO4/BABAM1 2 GO:0009649 entrainment of circadian clock 2/1165 34/18722 0.633789220539077 0.770012747810788 NR2F6/GNA11 2 GO:0010614 negative regulation of cardiac muscle hypertrophy 2/1165 34/18722 0.633789220539077 0.770012747810788 ATP2B4/TNFRSF1B 2 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 2/1165 34/18722 0.633789220539077 0.770012747810788 GSTO1/SLC8A1 2 GO:0019076 viral release from host cell 2/1165 34/18722 0.633789220539077 0.770012747810788 DDB1/PPIA 2 GO:0032212 positive regulation of telomere maintenance via telomerase 2/1165 34/18722 0.633789220539077 0.770012747810788 PKIB/CCT2 2 GO:0035137 hindlimb morphogenesis 2/1165 34/18722 0.633789220539077 0.770012747810788 GPC3/TBX3 2 GO:0035590 purinergic nucleotide receptor signaling pathway 2/1165 34/18722 0.633789220539077 0.770012747810788 GPR34/GNAI2 2 GO:0035890 exit from host 2/1165 34/18722 0.633789220539077 0.770012747810788 DDB1/PPIA 2 GO:0035891 exit from host cell 2/1165 34/18722 0.633789220539077 0.770012747810788 DDB1/PPIA 2 GO:0035909 aorta morphogenesis 2/1165 34/18722 0.633789220539077 0.770012747810788 SOX4/LRP1 2 GO:0048261 negative regulation of receptor-mediated endocytosis 2/1165 34/18722 0.633789220539077 0.770012747810788 LRPAP1/APOC1 2 GO:0048536 spleen development 2/1165 34/18722 0.633789220539077 0.770012747810788 PBX1/PRKDC 2 GO:0090075 relaxation of muscle 2/1165 34/18722 0.633789220539077 0.770012747810788 SOD1/SLC8A1 2 GO:0060419 heart growth 6/1165 104/18722 0.634341745111815 0.770350544204374 TGFBR3/GJA1/DUSP9/YAP1/BASP1/CCNB1 6 GO:1901890 positive regulation of cell junction assembly 6/1165 104/18722 0.634341745111815 0.770350544204374 DLG5/FERMT2/S100A10/NRP1/VEGFA/LIMS1 6 GO:0010662 regulation of striated muscle cell apoptotic process 3/1165 52/18722 0.636038560861205 0.771576494945741 BMP7/BNIP3/JAK2 3 GO:0034204 lipid translocation 3/1165 52/18722 0.636038560861205 0.771576494945741 KCNN4/ATP10D/PLSCR1 3 GO:0035176 social behavior 3/1165 52/18722 0.636038560861205 0.771576494945741 SLC6A4/TREM2/PCM1 3 GO:0035196 production of miRNAs involved in gene silencing by miRNA 3/1165 52/18722 0.636038560861205 0.771576494945741 EGFR/LIN28B/TGFB1 3 GO:0043090 amino acid import 3/1165 52/18722 0.636038560861205 0.771576494945741 ITGB1/ARL6IP5/SLC1A3 3 GO:0016101 diterpenoid metabolic process 5/1165 87/18722 0.636655405343338 0.771800590759314 LRP2/EGFR/ADH5/AKR1B1/LRP1 5 GO:0032886 regulation of microtubule-based process 14/1165 240/18722 0.637704611158864 0.771800590759314 MET/KLHL42/GNAI1/NPM1/RHOA/CLIP1/CLTC/ATF5/AKAP9/CIB1/STMN1/DEFB1/CATSPER1/RPS3 14 GO:0070085 glycosylation 14/1165 240/18722 0.637704611158864 0.771800590759314 TUSC3/EXTL2/GALNT11/DDOST/RPN2/FUT8/GFPT1/MAN1A2/SERP1/ST3GAL4/OSTC/C1GALT1/TMEM165/MGAT1 14 GO:0099111 microtubule-based transport 11/1165 190/18722 0.641293359240857 0.771800590759314 APP/PRKCZ/SOD1/UBB/ARMCX3/HSPB11/LRPPRC/DST/PCM1/CLN3/HSPA8 11 GO:0002827 positive regulation of T-helper 1 type immune response 1/1165 16/18722 0.642410896138877 0.771800590759314 SLC11A1 1 GO:0005980 glycogen catabolic process 1/1165 16/18722 0.642410896138877 0.771800590759314 AGL 1 GO:0006266 DNA ligation 1/1165 16/18722 0.642410896138877 0.771800590759314 TOP2A 1 GO:0006740 NADPH regeneration 1/1165 16/18722 0.642410896138877 0.771800590759314 RPIA 1 GO:0006750 glutathione biosynthetic process 1/1165 16/18722 0.642410896138877 0.771800590759314 GCLM 1 GO:0007635 chemosensory behavior 1/1165 16/18722 0.642410896138877 0.771800590759314 ATP6V1B1 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/1165 16/18722 0.642410896138877 0.771800590759314 CDYL 1 GO:0009299 mRNA transcription 1/1165 16/18722 0.642410896138877 0.771800590759314 FLNA 1 GO:0010819 regulation of T cell chemotaxis 1/1165 16/18722 0.642410896138877 0.771800590759314 CXCL10 1 GO:0019377 glycolipid catabolic process 1/1165 16/18722 0.642410896138877 0.771800590759314 FUCA1 1 GO:0031268 pseudopodium organization 1/1165 16/18722 0.642410896138877 0.771800590759314 RAB25 1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 1/1165 16/18722 0.642410896138877 0.771800590759314 EAPP 1 GO:0034374 low-density lipoprotein particle remodeling 1/1165 16/18722 0.642410896138877 0.771800590759314 APOE 1 GO:0035864 response to potassium ion 1/1165 16/18722 0.642410896138877 0.771800590759314 SOD1 1 GO:0042407 cristae formation 1/1165 16/18722 0.642410896138877 0.771800590759314 AFG3L2 1 GO:0044849 estrous cycle 1/1165 16/18722 0.642410896138877 0.771800590759314 PTN 1 GO:0045651 positive regulation of macrophage differentiation 1/1165 16/18722 0.642410896138877 0.771800590759314 TGFB1 1 GO:0045722 positive regulation of gluconeogenesis 1/1165 16/18722 0.642410896138877 0.771800590759314 DDB1 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/1165 16/18722 0.642410896138877 0.771800590759314 APOBEC3A 1 GO:0046036 CTP metabolic process 1/1165 16/18722 0.642410896138877 0.771800590759314 NME1 1 GO:0048557 embryonic digestive tract morphogenesis 1/1165 16/18722 0.642410896138877 0.771800590759314 GLI3 1 GO:0051969 regulation of transmission of nerve impulse 1/1165 16/18722 0.642410896138877 0.771800590759314 TYMP 1 GO:0055089 fatty acid homeostasis 1/1165 16/18722 0.642410896138877 0.771800590759314 APOE 1 GO:0060004 reflex 1/1165 16/18722 0.642410896138877 0.771800590759314 AFG3L2 1 GO:0060572 morphogenesis of an epithelial bud 1/1165 16/18722 0.642410896138877 0.771800590759314 BMP7 1 GO:0070200 establishment of protein localization to telomere 1/1165 16/18722 0.642410896138877 0.771800590759314 CCT2 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/1165 16/18722 0.642410896138877 0.771800590759314 ADAM8 1 GO:0070365 hepatocyte differentiation 1/1165 16/18722 0.642410896138877 0.771800590759314 KRT18 1 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 1/1165 16/18722 0.642410896138877 0.771800590759314 NFKBIA 1 GO:0071391 cellular response to estrogen stimulus 1/1165 16/18722 0.642410896138877 0.771800590759314 MDM2 1 GO:0071732 cellular response to nitric oxide 1/1165 16/18722 0.642410896138877 0.771800590759314 MTR 1 GO:0072109 glomerular mesangium development 1/1165 16/18722 0.642410896138877 0.771800590759314 BMP7 1 GO:0072283 metanephric renal vesicle morphogenesis 1/1165 16/18722 0.642410896138877 0.771800590759314 STAT1 1 GO:0080009 mRNA methylation 1/1165 16/18722 0.642410896138877 0.771800590759314 ZC3H13 1 GO:0090336 positive regulation of brown fat cell differentiation 1/1165 16/18722 0.642410896138877 0.771800590759314 BMP7 1 GO:0090520 sphingolipid mediated signaling pathway 1/1165 16/18722 0.642410896138877 0.771800590759314 S1PR4 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/1165 16/18722 0.642410896138877 0.771800590759314 ATP2B1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/1165 16/18722 0.642410896138877 0.771800590759314 SEMA6A 1 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/1165 16/18722 0.642410896138877 0.771800590759314 ANAPC11 1 GO:1903236 regulation of leukocyte tethering or rolling 1/1165 16/18722 0.642410896138877 0.771800590759314 ST3GAL4 1 GO:2001212 regulation of vasculogenesis 1/1165 16/18722 0.642410896138877 0.771800590759314 RRAS 1 GO:0045165 cell fate commitment 15/1165 258/18722 0.644964550048865 0.774702764695973 NR2F2/CTSL/ISL1/ESRP1/LMO4/GATA3/GLI3/EPAS1/TBX3/NRP1/ITGB1/PRKDC/RHOA/KLF4/RTF1 15 GO:0046486 glycerolipid metabolic process 23/1165 392/18722 0.646038590285184 0.775826830823864 PGAP2/DBI/SH3YL1/MGLL/APOE/PISD/GPX1/GPAA1/PGP/SLC44A2/SERINC2/PLSCR1/APOC1/PIK3C2A/TMEM150A/GPCPD1/STOML2/PRDX6/CLN3/SOCS3/SORL1/GK/APOBR 23 GO:0006325 chromatin organization 24/1165 409/18722 0.647681346169908 0.776783294244177 SMARCA1/GATA3/RBBP7/CBX4/NASP/HELLS/BRD4/NPM1/DNMT1/SMARCA2/HMGN3/TLK1/DNMT3A/RUVBL1/NUCKS1/GPX4/MKI67/HDAC2/SET/NUDT5/ACTB/MBD2/BABAM1/HMGN1 24 GO:0007034 vacuolar transport 9/1165 157/18722 0.648231950448939 0.776783294244177 LAPTM5/NDFIP2/VCP/VPS25/CLN3/HSPA8/LRP1/SORL1/GRN 9 GO:0001541 ovarian follicle development 3/1165 53/18722 0.648918499813107 0.776783294244177 SOD1/CEBPB/VEGFA 3 GO:0031279 regulation of cyclase activity 3/1165 53/18722 0.648918499813107 0.776783294244177 GNAS/AKAP9/GNAI2 3 GO:0032784 regulation of DNA-templated transcription, elongation 3/1165 53/18722 0.648918499813107 0.776783294244177 BRD4/EAPP/HMGN1 3 GO:0007292 female gamete generation 8/1165 140/18722 0.648937424700855 0.776783294244177 LGR5/ADAMTS1/ASPM/PTN/HPGD/UBB/TOP2A/CCNB1 8 GO:0000460 maturation of 5.8S rRNA 2/1165 35/18722 0.649602847529337 0.776783294244177 RPS21/PRKDC 2 GO:0001569 branching involved in blood vessel morphogenesis 2/1165 35/18722 0.649602847529337 0.776783294244177 NRP1/VEGFA 2 GO:0010664 negative regulation of striated muscle cell apoptotic process 2/1165 35/18722 0.649602847529337 0.776783294244177 BMP7/JAK2 2 GO:0018149 peptide cross-linking 2/1165 35/18722 0.649602847529337 0.776783294244177 DSP/TGM2 2 GO:0031076 embryonic camera-type eye development 2/1165 35/18722 0.649602847529337 0.776783294244177 BMP7/TFAP2A 2 GO:0032205 negative regulation of telomere maintenance 2/1165 35/18722 0.649602847529337 0.776783294244177 PARP1/RAD50 2 GO:0040001 establishment of mitotic spindle localization 2/1165 35/18722 0.649602847529337 0.776783294244177 GJA1/ITGB1 2 GO:0042462 eye photoreceptor cell development 2/1165 35/18722 0.649602847529337 0.776783294244177 MYO7A/VEGFA 2 GO:0045880 positive regulation of smoothened signaling pathway 2/1165 35/18722 0.649602847529337 0.776783294244177 DLG5/GPC3 2 GO:0045922 negative regulation of fatty acid metabolic process 2/1165 35/18722 0.649602847529337 0.776783294244177 APOC1/ACADVL 2 GO:0048821 erythrocyte development 2/1165 35/18722 0.649602847529337 0.776783294244177 KLF2/FAM210B 2 GO:0060236 regulation of mitotic spindle organization 2/1165 35/18722 0.649602847529337 0.776783294244177 GNAI1/CLTC 2 GO:0071108 protein K48-linked deubiquitination 2/1165 35/18722 0.649602847529337 0.776783294244177 USP27X/PARK7 2 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 2/1165 35/18722 0.649602847529337 0.776783294244177 GSTO1/SLC8A1 2 GO:0031570 DNA integrity checkpoint signaling 7/1165 123/18722 0.650325334026576 0.77748159742091 FOXO4/PRKDC/SOX4/EIF2AK4/CCND1/MDM2/BABAM1 7 GO:0050818 regulation of coagulation 4/1165 71/18722 0.652060100543968 0.779389553737924 PRDX2/APOE/CD9/ST3GAL4 4 GO:0046330 positive regulation of JNK cascade 5/1165 89/18722 0.65658962328072 0.78204247161567 APP/NCF1/PYCARD/GADD45G/HRAS 5 GO:0034470 ncRNA processing 23/1165 395/18722 0.660379460507954 0.78204247161567 LIN28B/RPS17/RPS21/MRPL1/RPS27/PRKDC/RPS28/SNU13/DDX27/DDX1/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/BRIX1/RPS7/NHP2/RPS16/NOP56/IMP3/RPL10A 23 GO:0031050 dsRNA processing 3/1165 54/18722 0.661470420145797 0.78204247161567 EGFR/LIN28B/TGFB1 3 GO:0032330 regulation of chondrocyte differentiation 3/1165 54/18722 0.661470420145797 0.78204247161567 EFEMP1/GLI3/SCIN 3 GO:0051703 biological process involved in intraspecies interaction between organisms 3/1165 54/18722 0.661470420145797 0.78204247161567 SLC6A4/TREM2/PCM1 3 GO:0070918 production of small RNA involved in gene silencing by RNA 3/1165 54/18722 0.661470420145797 0.78204247161567 EGFR/LIN28B/TGFB1 3 GO:0072698 protein localization to microtubule cytoskeleton 3/1165 54/18722 0.661470420145797 0.78204247161567 SNX10/GOLGB1/PCM1 3 GO:0001736 establishment of planar polarity 4/1165 72/18722 0.662932472308001 0.78204247161567 ZNRF3/GPC3/DAB2/RHOA 4 GO:0007164 establishment of tissue polarity 4/1165 72/18722 0.662932472308001 0.78204247161567 ZNRF3/GPC3/DAB2/RHOA 4 GO:0030032 lamellipodium assembly 4/1165 72/18722 0.662932472308001 0.78204247161567 ITGB1/VAV3/WASF2/ABI3 4 GO:0050709 negative regulation of protein secretion 4/1165 72/18722 0.662932472308001 0.78204247161567 FRMD4A/APOE/RSAD2/ERP29 4 GO:0051057 positive regulation of small GTPase mediated signal transduction 4/1165 72/18722 0.662932472308001 0.78204247161567 ADGRG1/NET1/TGM2/HRAS 4 GO:0055021 regulation of cardiac muscle tissue growth 4/1165 72/18722 0.662932472308001 0.78204247161567 TGFBR3/GJA1/YAP1/CCNB1 4 GO:0046467 membrane lipid biosynthetic process 8/1165 142/18722 0.664592098297836 0.78204247161567 HACD3/PLPP3/PGAP2/DEGS1/ORMDL1/GPAA1/ST3GAL4/GAL3ST4 8 GO:0001710 mesodermal cell fate commitment 1/1165 17/18722 0.664681360481772 0.78204247161567 KLF4 1 GO:0001780 neutrophil homeostasis 1/1165 17/18722 0.664681360481772 0.78204247161567 JAM3 1 GO:0003184 pulmonary valve morphogenesis 1/1165 17/18722 0.664681360481772 0.78204247161567 GJA5 1 GO:0006577 amino-acid betaine metabolic process 1/1165 17/18722 0.664681360481772 0.78204247161567 ALDH7A1 1 GO:0006744 ubiquinone biosynthetic process 1/1165 17/18722 0.664681360481772 0.78204247161567 COQ4 1 GO:0007379 segment specification 1/1165 17/18722 0.664681360481772 0.78204247161567 IRX2 1 GO:0008340 determination of adult lifespan 1/1165 17/18722 0.664681360481772 0.78204247161567 TFCP2L1 1 GO:0009251 glucan catabolic process 1/1165 17/18722 0.664681360481772 0.78204247161567 AGL 1 GO:0010470 regulation of gastrulation 1/1165 17/18722 0.664681360481772 0.78204247161567 DAG1 1 GO:0010612 regulation of cardiac muscle adaptation 1/1165 17/18722 0.664681360481772 0.78204247161567 ATP2B4 1 GO:0014856 skeletal muscle cell proliferation 1/1165 17/18722 0.664681360481772 0.78204247161567 JAK2 1 GO:0021513 spinal cord dorsal/ventral patterning 1/1165 17/18722 0.664681360481772 0.78204247161567 GLI3 1 GO:0030322 stabilization of membrane potential 1/1165 17/18722 0.664681360481772 0.78204247161567 KCNN4 1 GO:0031445 regulation of heterochromatin assembly 1/1165 17/18722 0.664681360481772 0.78204247161567 DNMT1 1 GO:0032048 cardiolipin metabolic process 1/1165 17/18722 0.664681360481772 0.78204247161567 STOML2 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/1165 17/18722 0.664681360481772 0.78204247161567 VPS25 1 GO:0033151 V(D)J recombination 1/1165 17/18722 0.664681360481772 0.78204247161567 PRKDC 1 GO:0034349 glial cell apoptotic process 1/1165 17/18722 0.664681360481772 0.78204247161567 TREM2 1 GO:0035518 histone H2A monoubiquitination 1/1165 17/18722 0.664681360481772 0.78204247161567 DDB1 1 GO:0036065 fucosylation 1/1165 17/18722 0.664681360481772 0.78204247161567 FUT8 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/1165 17/18722 0.664681360481772 0.78204247161567 PIK3C2A 1 GO:0042339 keratan sulfate metabolic process 1/1165 17/18722 0.664681360481772 0.78204247161567 ST3GAL4 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/1165 17/18722 0.664681360481772 0.78204247161567 SOCS3 1 GO:0048339 paraxial mesoderm development 1/1165 17/18722 0.664681360481772 0.78204247161567 YAP1 1 GO:0048521 negative regulation of behavior 1/1165 17/18722 0.664681360481772 0.78204247161567 RETN 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/1165 17/18722 0.664681360481772 0.78204247161567 SYT7 1 GO:0051580 regulation of neurotransmitter uptake 1/1165 17/18722 0.664681360481772 0.78204247161567 ITGB1 1 GO:0051797 regulation of hair follicle development 1/1165 17/18722 0.664681360481772 0.78204247161567 FERMT1 1 GO:0055003 cardiac myofibril assembly 1/1165 17/18722 0.664681360481772 0.78204247161567 OBSL1 1 GO:0055064 chloride ion homeostasis 1/1165 17/18722 0.664681360481772 0.78204247161567 ATP6V1B1 1 GO:0055083 monovalent inorganic anion homeostasis 1/1165 17/18722 0.664681360481772 0.78204247161567 ATP6V1B1 1 GO:0055119 relaxation of cardiac muscle 1/1165 17/18722 0.664681360481772 0.78204247161567 SLC8A1 1 GO:0070206 protein trimerization 1/1165 17/18722 0.664681360481772 0.78204247161567 CD74 1 GO:0070593 dendrite self-avoidance 1/1165 17/18722 0.664681360481772 0.78204247161567 BSG 1 GO:0071371 cellular response to gonadotropin stimulus 1/1165 17/18722 0.664681360481772 0.78204247161567 GCLM 1 GO:0090036 regulation of protein kinase C signaling 1/1165 17/18722 0.664681360481772 0.78204247161567 VEGFA 1 GO:0090494 dopamine uptake 1/1165 17/18722 0.664681360481772 0.78204247161567 PARK7 1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 1/1165 17/18722 0.664681360481772 0.78204247161567 AKAP9 1 GO:0120261 regulation of heterochromatin organization 1/1165 17/18722 0.664681360481772 0.78204247161567 DNMT1 1 GO:1901550 regulation of endothelial cell development 1/1165 17/18722 0.664681360481772 0.78204247161567 VEGFA 1 GO:1901569 fatty acid derivative catabolic process 1/1165 17/18722 0.664681360481772 0.78204247161567 HPGD 1 GO:1901663 quinone biosynthetic process 1/1165 17/18722 0.664681360481772 0.78204247161567 COQ4 1 GO:1903140 regulation of establishment of endothelial barrier 1/1165 17/18722 0.664681360481772 0.78204247161567 VEGFA 1 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 1/1165 17/18722 0.664681360481772 0.78204247161567 ATP2B4 1 GO:1903818 positive regulation of voltage-gated potassium channel activity 1/1165 17/18722 0.664681360481772 0.78204247161567 TREM2 1 GO:1904262 negative regulation of TORC1 signaling 1/1165 17/18722 0.664681360481772 0.78204247161567 SESN1 1 GO:1904355 positive regulation of telomere capping 1/1165 17/18722 0.664681360481772 0.78204247161567 PKIB 1 GO:2000811 negative regulation of anoikis 1/1165 17/18722 0.664681360481772 0.78204247161567 ITGB1 1 GO:0003352 regulation of cilium movement 2/1165 36/18722 0.664868461526809 0.78204247161567 DEFB1/CATSPER1 2 GO:0006699 bile acid biosynthetic process 2/1165 36/18722 0.664868461526809 0.78204247161567 SLC27A2/OSBPL9 2 GO:0008207 C21-steroid hormone metabolic process 2/1165 36/18722 0.664868461526809 0.78204247161567 AKR1B1/TSPO 2 GO:0010923 negative regulation of phosphatase activity 2/1165 36/18722 0.664868461526809 0.78204247161567 LGALS3/GNAI2 2 GO:0014741 negative regulation of muscle hypertrophy 2/1165 36/18722 0.664868461526809 0.78204247161567 ATP2B4/TNFRSF1B 2 GO:0044060 regulation of endocrine process 2/1165 36/18722 0.664868461526809 0.78204247161567 GJA1/RETN 2 GO:0044743 protein transmembrane import into intracellular organelle 2/1165 36/18722 0.664868461526809 0.78204247161567 HSPD1/ROMO1 2 GO:0045738 negative regulation of DNA repair 2/1165 36/18722 0.664868461526809 0.78204247161567 MAGEF1/RPS3 2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 2/1165 36/18722 0.664868461526809 0.78204247161567 NCF1/PLAUR 2 GO:0045746 negative regulation of Notch signaling pathway 2/1165 36/18722 0.664868461526809 0.78204247161567 BMP7/NFKBIA 2 GO:0051955 regulation of amino acid transport 2/1165 36/18722 0.664868461526809 0.78204247161567 ITGB1/ARL6IP5 2 GO:0070306 lens fiber cell differentiation 2/1165 36/18722 0.664868461526809 0.78204247161567 VIM/SKIL 2 GO:0070897 transcription preinitiation complex assembly 2/1165 36/18722 0.664868461526809 0.78204247161567 TAF11/PSMC6 2 GO:0086010 membrane depolarization during action potential 2/1165 36/18722 0.664868461526809 0.78204247161567 ANK3/SLC8A1 2 GO:0051053 negative regulation of DNA metabolic process 7/1165 125/18722 0.666947373603723 0.784323404156232 GJA1/GATA3/PARP1/DUSP1/MAGEF1/RAD50/RPS3 7 GO:0017148 negative regulation of translation 14/1165 245/18722 0.667921171194857 0.785304049835931 IGF2BP3/GAPDH/ZFP36/EIF2AK1/DHX36/EIF2AK4/PABPC1/CALR/YBX1/TYMS/NCL/ZFP36L1/RPS3/CIRBP 14 GO:0060402 calcium ion transport into cytosol 9/1165 160/18722 0.6703439592722 0.787827308337815 CYBA/PTPRC/ATP2B4/PTPN6/GSTO1/ERO1A/CXCL10/SLC8A1/LYN 9 GO:0098659 inorganic cation import across plasma membrane 6/1165 108/18722 0.670488339912656 0.787827308337815 SLC39A10/SLC9A1/DLG1/ATP2B4/ISCU/SLC8A1 6 GO:0099587 inorganic ion import across plasma membrane 6/1165 108/18722 0.670488339912656 0.787827308337815 SLC39A10/SLC9A1/DLG1/ATP2B4/ISCU/SLC8A1 6 GO:0032456 endocytic recycling 4/1165 73/18722 0.673571301623184 0.791096872146297 NSG1/RAB11A/SNX3/SORL1 4 GO:1904427 positive regulation of calcium ion transmembrane transport 4/1165 73/18722 0.673571301623184 0.791096872146297 SLC9A1/GSTO1/VMP1/CXCL10 4 GO:1905517 macrophage migration 3/1165 55/18722 0.673693755364208 0.791096872146297 LGALS3/CD9/TREM2 3 GO:0003002 regionalization 19/1165 331/18722 0.675807176287762 0.792628143188642 LRP2/ADGRG1/NR2F2/PBX1/WLS/LRP5/ISL1/NRP2/GLI3/IRX2/GPC3/TBX3/NRP1/C1QA/PRKDC/PRKACB/HSPB11/BASP1/BHLHE41 19 GO:0006354 DNA-templated transcription, elongation 5/1165 91/18722 0.675807947014439 0.792628143188642 BRD4/RTF1/POLR2I/EAPP/HMGN1 5 GO:0042147 retrograde transport, endosome to Golgi 5/1165 91/18722 0.675807947014439 0.792628143188642 RHOBTB3/CLTC/ARL1/SNX6/SNX3 5 GO:0035725 sodium ion transmembrane transport 10/1165 178/18722 0.675935825076844 0.792628143188642 SLC6A4/FXYD3/ANK3/SLC9A1/DLG1/FXYD5/ATP2B4/GLRX/SLC8A1/UTRN 10 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2/1165 37/18722 0.679592971468243 0.792628143188642 PABPC1/PNRC2 2 GO:0021532 neural tube patterning 2/1165 37/18722 0.679592971468243 0.792628143188642 GLI3/PRKACB 2 GO:0031646 positive regulation of nervous system process 2/1165 37/18722 0.679592971468243 0.792628143188642 DAG1/TNFRSF1B 2 GO:0034260 negative regulation of GTPase activity 2/1165 37/18722 0.679592971468243 0.792628143188642 AMOT/HRAS 2 GO:0043029 T cell homeostasis 2/1165 37/18722 0.679592971468243 0.792628143188642 PMAIP1/TSC22D3 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/1165 37/18722 0.679592971468243 0.792628143188642 CRIM1/IGF1R 2 GO:0050775 positive regulation of dendrite morphogenesis 2/1165 37/18722 0.679592971468243 0.792628143188642 OBSL1/DHX36 2 GO:0051294 establishment of spindle orientation 2/1165 37/18722 0.679592971468243 0.792628143188642 GJA1/ITGB1 2 GO:0060428 lung epithelium development 2/1165 37/18722 0.679592971468243 0.792628143188642 YAP1/KLF2 2 GO:0071542 dopaminergic neuron differentiation 2/1165 37/18722 0.679592971468243 0.792628143188642 VEGFA/MANF 2 GO:0010324 membrane invagination 8/1165 144/18722 0.679822447763767 0.792628143188642 AIF1/FNBP1L/RHOA/RHOBTB1/TREM2/RHOG/SNX3/CD300A 8 GO:0045055 regulated exocytosis 13/1165 230/18722 0.67989527733183 0.792628143188642 SYT7/SCIN/ANXA3/STXBP2/HLA-F/S100A13/SPI1/HCK/FGR/GNAI2/SYK/CD300A/LYN 13 GO:0001505 regulation of neurotransmitter levels 12/1165 213/18722 0.680457001804122 0.792628143188642 SLC6A4/SLC38A1/SYT7/STXBP2/COMT/ITGB1/PNKD/SLC1A3/SLC29A1/PARK7/CLN3/NR4A1 12 GO:0006497 protein lipidation 5/1165 92/18722 0.685144436744696 0.792628143188642 PGAP2/DBI/GPAA1/NMT1/GLUL 5 GO:0034502 protein localization to chromosome 5/1165 92/18722 0.685144436744696 0.792628143188642 VCP/CCT2/SPI1/GNL3/RAD21 5 GO:0070509 calcium ion import 5/1165 92/18722 0.685144436744696 0.792628143188642 LGALS3/AFG3L2/ATP2B4/SLC8A1/VDAC1 5 GO:0000712 resolution of meiotic recombination intermediates 1/1165 18/18722 0.685565948294589 0.792628143188642 TOP2A 1 GO:0001522 pseudouridine synthesis 1/1165 18/18722 0.685565948294589 0.792628143188642 NHP2 1 GO:0001946 lymphangiogenesis 1/1165 18/18722 0.685565948294589 0.792628143188642 PTPN14 1 GO:0002076 osteoblast development 1/1165 18/18722 0.685565948294589 0.792628143188642 LRP5 1 GO:0006337 nucleosome disassembly 1/1165 18/18722 0.685565948294589 0.792628143188642 SET 1 GO:0006957 complement activation, alternative pathway 1/1165 18/18722 0.685565948294589 0.792628143188642 CFP 1 GO:0006991 response to sterol depletion 1/1165 18/18722 0.685565948294589 0.792628143188642 LYN 1 GO:0007549 dosage compensation 1/1165 18/18722 0.685565948294589 0.792628143188642 CDYL 1 GO:0009404 toxin metabolic process 1/1165 18/18722 0.685565948294589 0.792628143188642 ARL1 1 GO:0010663 positive regulation of striated muscle cell apoptotic process 1/1165 18/18722 0.685565948294589 0.792628143188642 BNIP3 1 GO:0010666 positive regulation of cardiac muscle cell apoptotic process 1/1165 18/18722 0.685565948294589 0.792628143188642 BNIP3 1 GO:0015732 prostaglandin transport 1/1165 18/18722 0.685565948294589 0.792628143188642 PTGES 1 GO:0019184 nonribosomal peptide biosynthetic process 1/1165 18/18722 0.685565948294589 0.792628143188642 GCLM 1 GO:0019896 axonal transport of mitochondrion 1/1165 18/18722 0.685565948294589 0.792628143188642 ARMCX3 1 GO:0021511 spinal cord patterning 1/1165 18/18722 0.685565948294589 0.792628143188642 GLI3 1 GO:0030206 chondroitin sulfate biosynthetic process 1/1165 18/18722 0.685565948294589 0.792628143188642 CHPF 1 GO:0030299 intestinal cholesterol absorption 1/1165 18/18722 0.685565948294589 0.792628143188642 LIMA1 1 GO:0032095 regulation of response to food 1/1165 18/18722 0.685565948294589 0.792628143188642 NENF 1 GO:0032305 positive regulation of icosanoid secretion 1/1165 18/18722 0.685565948294589 0.792628143188642 PTGES 1 GO:0032769 negative regulation of monooxygenase activity 1/1165 18/18722 0.685565948294589 0.792628143188642 ATP2B4 1 GO:0032785 negative regulation of DNA-templated transcription, elongation 1/1165 18/18722 0.685565948294589 0.792628143188642 EAPP 1 GO:0034162 toll-like receptor 9 signaling pathway 1/1165 18/18722 0.685565948294589 0.792628143188642 RSAD2 1 GO:0036499 PERK-mediated unfolded protein response 1/1165 18/18722 0.685565948294589 0.792628143188642 HSPA5 1 GO:0036507 protein demannosylation 1/1165 18/18722 0.685565948294589 0.792628143188642 MAN1A2 1 GO:0036508 protein alpha-1,2-demannosylation 1/1165 18/18722 0.685565948294589 0.792628143188642 MAN1A2 1 GO:0042136 neurotransmitter biosynthetic process 1/1165 18/18722 0.685565948294589 0.792628143188642 SLC6A4 1 GO:0042693 muscle cell fate commitment 1/1165 18/18722 0.685565948294589 0.792628143188642 TBX3 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/1165 18/18722 0.685565948294589 0.792628143188642 NCL 1 GO:0044247 cellular polysaccharide catabolic process 1/1165 18/18722 0.685565948294589 0.792628143188642 AGL 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/1165 18/18722 0.685565948294589 0.792628143188642 ADRB1 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/1165 18/18722 0.685565948294589 0.792628143188642 SYT7 1 GO:0046112 nucleobase biosynthetic process 1/1165 18/18722 0.685565948294589 0.792628143188642 PAICS 1 GO:0048535 lymph node development 1/1165 18/18722 0.685565948294589 0.792628143188642 TGFB1 1 GO:0048643 positive regulation of skeletal muscle tissue development 1/1165 18/18722 0.685565948294589 0.792628143188642 IGF2 1 GO:0051382 kinetochore assembly 1/1165 18/18722 0.685565948294589 0.792628143188642 CENPF 1 GO:0051895 negative regulation of focal adhesion assembly 1/1165 18/18722 0.685565948294589 0.792628143188642 LRP1 1 GO:0060192 negative regulation of lipase activity 1/1165 18/18722 0.685565948294589 0.792628143188642 APOC1 1 GO:0060602 branch elongation of an epithelium 1/1165 18/18722 0.685565948294589 0.792628143188642 YAP1 1 GO:0060716 labyrinthine layer blood vessel development 1/1165 18/18722 0.685565948294589 0.792628143188642 JUNB 1 GO:0061687 detoxification of inorganic compound 1/1165 18/18722 0.685565948294589 0.792628143188642 PARK7 1 GO:0071071 regulation of phospholipid biosynthetic process 1/1165 18/18722 0.685565948294589 0.792628143188642 IDH1 1 GO:0072189 ureter development 1/1165 18/18722 0.685565948294589 0.792628143188642 GATA3 1 GO:0080182 histone H3-K4 trimethylation 1/1165 18/18722 0.685565948294589 0.792628143188642 RTF1 1 GO:0097107 postsynaptic density assembly 1/1165 18/18722 0.685565948294589 0.792628143188642 ABI3 1 GO:0099558 maintenance of synapse structure 1/1165 18/18722 0.685565948294589 0.792628143188642 DLG1 1 GO:0150078 positive regulation of neuroinflammatory response 1/1165 18/18722 0.685565948294589 0.792628143188642 TREM2 1 GO:0150118 negative regulation of cell-substrate junction organization 1/1165 18/18722 0.685565948294589 0.792628143188642 LRP1 1 GO:1901317 regulation of flagellated sperm motility 1/1165 18/18722 0.685565948294589 0.792628143188642 DEFB1 1 GO:1902001 fatty acid transmembrane transport 1/1165 18/18722 0.685565948294589 0.792628143188642 SLC2A1 1 GO:1902074 response to salt 1/1165 18/18722 0.685565948294589 0.792628143188642 HSPA5 1 GO:1902170 cellular response to reactive nitrogen species 1/1165 18/18722 0.685565948294589 0.792628143188642 MTR 1 GO:2001135 regulation of endocytic recycling 1/1165 18/18722 0.685565948294589 0.792628143188642 SORL1 1 GO:0002090 regulation of receptor internalization 3/1165 56/18722 0.685588746691761 0.792628143188642 LRPAP1/VEGFA/SYK 3 GO:0010658 striated muscle cell apoptotic process 3/1165 56/18722 0.685588746691761 0.792628143188642 BMP7/BNIP3/JAK2 3 GO:0030166 proteoglycan biosynthetic process 3/1165 56/18722 0.685588746691761 0.792628143188642 CHPF/EXTL2/GAL3ST4 3 GO:0009101 glycoprotein biosynthetic process 18/1165 317/18722 0.690519370078874 0.798164173033921 CHPF/TUSC3/EXTL2/PAWR/GALNT11/DDOST/RPN2/ITM2C/FUT8/GFPT1/MAN1A2/SERP1/ST3GAL4/OSTC/C1GALT1/TMEM165/MGAT1/GAL3ST4 18 GO:0006639 acylglycerol metabolic process 7/1165 128/18722 0.690950078324917 0.798497588972155 MGLL/APOE/GPX1/APOC1/SORL1/GK/APOBR 7 GO:0061025 membrane fusion 9/1165 163/18722 0.69161003896241 0.799095749011117 CTSL/SPESP1/FOLR1/SYT7/VAV3/CD9/SAMD9/RABEP1/CLN3 9 GO:0000578 embryonic axis specification 2/1165 38/18722 0.693784548101566 0.80045481366785 TBX3/BASP1 2 GO:0010719 negative regulation of epithelial to mesenchymal transition 2/1165 38/18722 0.693784548101566 0.80045481366785 GATA3/EFNA1 2 GO:0032717 negative regulation of interleukin-8 production 2/1165 38/18722 0.693784548101566 0.80045481366785 TMSB4X/KLF4 2 GO:0035136 forelimb morphogenesis 2/1165 38/18722 0.693784548101566 0.80045481366785 TFAP2A/TBX3 2 GO:0035337 fatty-acyl-CoA metabolic process 2/1165 38/18722 0.693784548101566 0.80045481366785 TECR/SLC25A1 2 GO:1901186 positive regulation of ERBB signaling pathway 2/1165 38/18722 0.693784548101566 0.80045481366785 NCF1/PLAUR 2 GO:2000279 negative regulation of DNA biosynthetic process 2/1165 38/18722 0.693784548101566 0.80045481366785 GJA1/DUSP1 2 GO:0006024 glycosaminoglycan biosynthetic process 4/1165 75/18722 0.694143936620026 0.800704873869339 CHPF/CLTC/TGFB1/ST3GAL4 4 GO:1901019 regulation of calcium ion transmembrane transporter activity 5/1165 93/18722 0.694297549852865 0.800717515373769 SLC9A1/C4orf3/GSTO1/VMP1/YWHAE 5 GO:0034205 amyloid-beta formation 3/1165 57/18722 0.697156378054647 0.803354290704318 EFNA1/APOE/SORL1 3 GO:0050879 multicellular organismal movement 3/1165 57/18722 0.697156378054647 0.803354290704318 GSTO1/C12orf57/NR4A1 3 GO:0050881 musculoskeletal movement 3/1165 57/18722 0.697156378054647 0.803354290704318 GSTO1/C12orf57/NR4A1 3 GO:0051785 positive regulation of nuclear division 3/1165 57/18722 0.697156378054647 0.803354290704318 LRP5/ANAPC11/IGF2 3 GO:0006022 aminoglycan metabolic process 7/1165 129/18722 0.698697886137409 0.804800171329628 ITIH5/CHPF/CD44/FUCA1/CLTC/TGFB1/ST3GAL4 7 GO:0006638 neutral lipid metabolic process 7/1165 129/18722 0.698697886137409 0.804800171329628 MGLL/APOE/GPX1/APOC1/SORL1/GK/APOBR 7 GO:0048285 organelle fission 28/1165 488/18722 0.700379984671045 0.806572189979191 BMP7/LRP5/ASPM/OBSL1/DUSP1/RHOA/AURKAIP1/CCNE1/UBB/FLNA/EPS8/RAN/RAD50/ANAPC11/CKS2/RANBP1/MKI67/CENPF/CALR/IGF2/NAA10/FIS1/RAD21/BNIP3/RAB11A/TOP2A/SMC3/CCNB1 28 GO:0048704 embryonic skeletal system morphogenesis 5/1165 94/18722 0.703266472390853 0.806769592670151 BMP7/TFAP2A/GLI3/DLG1/SLC39A1 5 GO:0000956 nuclear-transcribed mRNA catabolic process 6/1165 112/18722 0.70427686279126 0.806769592670151 ZFP36/LSM7/DHX36/PABPC1/ZFP36L1/PNRC2 6 GO:0001676 long-chain fatty acid metabolic process 6/1165 112/18722 0.70427686279126 0.806769592670151 SLC27A2/MGLL/GPX1/AIG1/GSTP1/GPX4 6 GO:0001696 gastric acid secretion 1/1165 19/18722 0.705150832289286 0.806769592670151 SNX10 1 GO:0006044 N-acetylglucosamine metabolic process 1/1165 19/18722 0.705150832289286 0.806769592670151 EXTL2 1 GO:0006144 purine nucleobase metabolic process 1/1165 19/18722 0.705150832289286 0.806769592670151 PAICS 1 GO:0006670 sphingosine metabolic process 1/1165 19/18722 0.705150832289286 0.806769592670151 PLPP3 1 GO:0006743 ubiquinone metabolic process 1/1165 19/18722 0.705150832289286 0.806769592670151 COQ4 1 GO:0007530 sex determination 1/1165 19/18722 0.705150832289286 0.806769592670151 SF1 1 GO:0009081 branched-chain amino acid metabolic process 1/1165 19/18722 0.705150832289286 0.806769592670151 ECHS1 1 GO:0009226 nucleotide-sugar biosynthetic process 1/1165 19/18722 0.705150832289286 0.806769592670151 GFPT1 1 GO:0010829 negative regulation of glucose transmembrane transport 1/1165 19/18722 0.705150832289286 0.806769592670151 PEA15 1 GO:0010885 regulation of cholesterol storage 1/1165 19/18722 0.705150832289286 0.806769592670151 TREM2 1 GO:0031065 positive regulation of histone deacetylation 1/1165 19/18722 0.705150832289286 0.806769592670151 VEGFA 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/1165 19/18722 0.705150832289286 0.806769592670151 TECR 1 GO:0042776 mitochondrial ATP synthesis coupled proton transport 1/1165 19/18722 0.705150832289286 0.806769592670151 STOML2 1 GO:0044003 modulation by symbiont of host process 1/1165 19/18722 0.705150832289286 0.806769592670151 DAG1 1 GO:0045618 positive regulation of keratinocyte differentiation 1/1165 19/18722 0.705150832289286 0.806769592670151 NCOA3 1 GO:0045821 positive regulation of glycolytic process 1/1165 19/18722 0.705150832289286 0.806769592670151 APP 1 GO:0051546 keratinocyte migration 1/1165 19/18722 0.705150832289286 0.806769592670151 FERMT1 1 GO:0051957 positive regulation of amino acid transport 1/1165 19/18722 0.705150832289286 0.806769592670151 ITGB1 1 GO:0060039 pericardium development 1/1165 19/18722 0.705150832289286 0.806769592670151 BMP7 1 GO:0060065 uterus development 1/1165 19/18722 0.705150832289286 0.806769592670151 GATA3 1 GO:0070734 histone H3-K27 methylation 1/1165 19/18722 0.705150832289286 0.806769592670151 GATA3 1 GO:0072077 renal vesicle morphogenesis 1/1165 19/18722 0.705150832289286 0.806769592670151 STAT1 1 GO:0097623 potassium ion export across plasma membrane 1/1165 19/18722 0.705150832289286 0.806769592670151 DLG1 1 GO:0140131 positive regulation of lymphocyte chemotaxis 1/1165 19/18722 0.705150832289286 0.806769592670151 CCL4 1 GO:1901881 positive regulation of protein depolymerization 1/1165 19/18722 0.705150832289286 0.806769592670151 DSTN 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/1165 19/18722 0.705150832289286 0.806769592670151 PARK7 1 GO:2000042 negative regulation of double-strand break repair via homologous recombination 1/1165 19/18722 0.705150832289286 0.806769592670151 MAGEF1 1 GO:2000269 regulation of fibroblast apoptotic process 1/1165 19/18722 0.705150832289286 0.806769592670151 STK17A 1 GO:2000831 regulation of steroid hormone secretion 1/1165 19/18722 0.705150832289286 0.806769592670151 RETN 1 GO:0006352 DNA-templated transcription, initiation 7/1165 130/18722 0.706317551886339 0.807427927688764 TFAM/TAF11/DHX36/PSMC6/POLR2I/BCLAF1/JUN 7 GO:0051028 mRNA transport 7/1165 130/18722 0.706317551886339 0.807427927688764 IGF2BP3/ZFP36/NCBP3/MX2/LRPPRC/ZFP36L1/NUP214 7 GO:0001941 postsynaptic membrane organization 2/1165 39/18722 0.707452440472713 0.807427927688764 APOE/PTN 2 GO:0016572 histone phosphorylation 2/1165 39/18722 0.707452440472713 0.807427927688764 JAK2/CCNB1 2 GO:0017158 regulation of calcium ion-dependent exocytosis 2/1165 39/18722 0.707452440472713 0.807427927688764 SYT7/GNAI2 2 GO:0036297 interstrand cross-link repair 2/1165 39/18722 0.707452440472713 0.807427927688764 VCP/NUCKS1 2 GO:0045823 positive regulation of heart contraction 2/1165 39/18722 0.707452440472713 0.807427927688764 ADRB1/GCH1 2 GO:0046461 neutral lipid catabolic process 2/1165 39/18722 0.707452440472713 0.807427927688764 MGLL/SORL1 2 GO:0046464 acylglycerol catabolic process 2/1165 39/18722 0.707452440472713 0.807427927688764 MGLL/SORL1 2 GO:0051154 negative regulation of striated muscle cell differentiation 2/1165 39/18722 0.707452440472713 0.807427927688764 BHLHE41/YBX1 2 GO:0090207 regulation of triglyceride metabolic process 2/1165 39/18722 0.707452440472713 0.807427927688764 APOE/SORL1 2 GO:0090224 regulation of spindle organization 2/1165 39/18722 0.707452440472713 0.807427927688764 GNAI1/CLTC 2 GO:0007131 reciprocal meiotic recombination 3/1165 58/18722 0.708398313957471 0.807850413702414 RAD50/RAD21/TOP2A 3 GO:0044380 protein localization to cytoskeleton 3/1165 58/18722 0.708398313957471 0.807850413702414 SNX10/GOLGB1/PCM1 3 GO:0097035 regulation of membrane lipid distribution 3/1165 58/18722 0.708398313957471 0.807850413702414 KCNN4/ATP10D/PLSCR1 3 GO:0140527 reciprocal homologous recombination 3/1165 58/18722 0.708398313957471 0.807850413702414 RAD50/RAD21/TOP2A 3 GO:0018209 peptidyl-serine modification 19/1165 338/18722 0.710083605290747 0.809607815660565 EGFR/APP/CD44/PRKCZ/PARP1/TFRC/HSP90AB1/HSP90AA1/PRKDC/VEGFA/LATS2/TLK1/ATP2B4/AKAP9/TGFB1/PARK7/NAA10/SYK/CCNB1 19 GO:0042445 hormone metabolic process 12/1165 218/18722 0.710599240551929 0.810031181400889 HSD17B1/ENPEP/MME/CTSL/GATA3/COMT/AKR1B1/IL4I1/FDX1/HSD17B11/TSPO/CGA 12 GO:0008654 phospholipid biosynthetic process 14/1165 253/18722 0.713228313568903 0.812863050571016 ISYNA1/PGAP2/SH3YL1/IDH1/PISD/GPAA1/FDPS/SLC44A2/PLSCR1/PIK3C2A/TMEM150A/PMVK/CLN3/SOCS3 14 GO:0000380 alternative mRNA splicing, via spliceosome 4/1165 77/18722 0.713773769121593 0.813154488751674 MBNL3/MBNL2/RBM17/SRSF2 4 GO:0006367 transcription initiation from RNA polymerase II promoter 4/1165 77/18722 0.713773769121593 0.813154488751674 TAF11/DHX36/PSMC6/POLR2I 4 GO:2001257 regulation of cation channel activity 10/1165 184/18722 0.71526425380687 0.814687146229294 CTSS/APP/TMSB4X/ANK3/IFNGR2/KCNG1/ITGB1/DLG1/GSTO1/TREM2 10 GO:0019369 arachidonic acid metabolic process 3/1165 59/18722 0.719316840270474 0.815481922560779 MGLL/GPX1/GPX4 3 GO:0051568 histone H3-K4 methylation 3/1165 59/18722 0.719316840270474 0.815481922560779 GATA3/DNMT1/RTF1 3 GO:0071806 protein transmembrane transport 3/1165 59/18722 0.719316840270474 0.815481922560779 HSPD1/HSPA5/ROMO1 3 GO:0006650 glycerophospholipid metabolic process 17/1165 306/18722 0.72059641891927 0.815481922560779 PGAP2/DBI/SH3YL1/PISD/GPAA1/PGP/SLC44A2/SERINC2/PLSCR1/APOC1/PIK3C2A/TMEM150A/GPCPD1/STOML2/PRDX6/CLN3/SOCS3 17 GO:0006730 one-carbon metabolic process 2/1165 40/18722 0.720606810332391 0.815481922560779 CA8/TYMS 2 GO:0007339 binding of sperm to zona pellucida 2/1165 40/18722 0.720606810332391 0.815481922560779 ALDOA/CCT2 2 GO:0031111 negative regulation of microtubule polymerization or depolymerization 2/1165 40/18722 0.720606810332391 0.815481922560779 CIB1/STMN1 2 GO:0032892 positive regulation of organic acid transport 2/1165 40/18722 0.720606810332391 0.815481922560779 PTGES/ITGB1 2 GO:0042073 intraciliary transport 2/1165 40/18722 0.720606810332391 0.815481922560779 HSPB11/PCM1 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/1165 40/18722 0.720606810332391 0.815481922560779 GSTO1/CXCL10 2 GO:1901661 quinone metabolic process 2/1165 40/18722 0.720606810332391 0.815481922560779 AKR1B1/COQ4 2 GO:0042632 cholesterol homeostasis 5/1165 96/18722 0.720649921965907 0.815481922560779 LRP5/CD24/LIMA1/APOE/MYLIP 5 GO:0048705 skeletal system morphogenesis 12/1165 220/18722 0.722146301947588 0.815481922560779 FBN2/BMP7/LRP5/SERPINH1/TFAP2A/GLI3/ARID5B/MSX2/DLG1/DLX5/SLC39A1/FGR 12 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/1165 20/18722 0.72351683134735 0.815481922560779 BRD4 1 GO:0000272 polysaccharide catabolic process 1/1165 20/18722 0.72351683134735 0.815481922560779 AGL 1 GO:0001832 blastocyst growth 1/1165 20/18722 0.72351683134735 0.815481922560779 RTF1 1 GO:0007620 copulation 1/1165 20/18722 0.72351683134735 0.815481922560779 SLC6A4 1 GO:0010523 negative regulation of calcium ion transport into cytosol 1/1165 20/18722 0.72351683134735 0.815481922560779 GSTO1 1 GO:0010893 positive regulation of steroid biosynthetic process 1/1165 20/18722 0.72351683134735 0.815481922560779 CGA 1 GO:0014047 glutamate secretion 1/1165 20/18722 0.72351683134735 0.815481922560779 GJA1 1 GO:0017121 plasma membrane phospholipid scrambling 1/1165 20/18722 0.72351683134735 0.815481922560779 PLSCR1 1 GO:0021516 dorsal spinal cord development 1/1165 20/18722 0.72351683134735 0.815481922560779 LMO4 1 GO:0030150 protein import into mitochondrial matrix 1/1165 20/18722 0.72351683134735 0.815481922560779 ROMO1 1 GO:0031498 chromatin disassembly 1/1165 20/18722 0.72351683134735 0.815481922560779 SET 1 GO:0032332 positive regulation of chondrocyte differentiation 1/1165 20/18722 0.72351683134735 0.815481922560779 GLI3 1 GO:0032793 positive regulation of CREB transcription factor activity 1/1165 20/18722 0.72351683134735 0.815481922560779 VEGFA 1 GO:0034104 negative regulation of tissue remodeling 1/1165 20/18722 0.72351683134735 0.815481922560779 CST3 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/1165 20/18722 0.72351683134735 0.815481922560779 ITM2C 1 GO:0043046 DNA methylation involved in gamete generation 1/1165 20/18722 0.72351683134735 0.815481922560779 DNMT3A 1 GO:0043651 linoleic acid metabolic process 1/1165 20/18722 0.72351683134735 0.815481922560779 GSTP1 1 GO:0043691 reverse cholesterol transport 1/1165 20/18722 0.72351683134735 0.815481922560779 APOE 1 GO:0043984 histone H4-K16 acetylation 1/1165 20/18722 0.72351683134735 0.815481922560779 PHF20 1 GO:0045844 positive regulation of striated muscle tissue development 1/1165 20/18722 0.72351683134735 0.815481922560779 IGF2 1 GO:0046931 pore complex assembly 1/1165 20/18722 0.72351683134735 0.815481922560779 BAD 1 GO:0048636 positive regulation of muscle organ development 1/1165 20/18722 0.72351683134735 0.815481922560779 IGF2 1 GO:0048670 regulation of collateral sprouting 1/1165 20/18722 0.72351683134735 0.815481922560779 LRP1 1 GO:0051004 regulation of lipoprotein lipase activity 1/1165 20/18722 0.72351683134735 0.815481922560779 APOC1 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/1165 20/18722 0.72351683134735 0.815481922560779 GJA1 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/1165 20/18722 0.72351683134735 0.815481922560779 DHX36 1 GO:0070932 histone H3 deacetylation 1/1165 20/18722 0.72351683134735 0.815481922560779 HDAC2 1 GO:0071397 cellular response to cholesterol 1/1165 20/18722 0.72351683134735 0.815481922560779 DAG1 1 GO:0071625 vocalization behavior 1/1165 20/18722 0.72351683134735 0.815481922560779 GLI3 1 GO:0071731 response to nitric oxide 1/1165 20/18722 0.72351683134735 0.815481922560779 MTR 1 GO:0072087 renal vesicle development 1/1165 20/18722 0.72351683134735 0.815481922560779 STAT1 1 GO:0090201 negative regulation of release of cytochrome c from mitochondria 1/1165 20/18722 0.72351683134735 0.815481922560779 GPX1 1 GO:0097503 sialylation 1/1165 20/18722 0.72351683134735 0.815481922560779 ST3GAL4 1 GO:1902004 positive regulation of amyloid-beta formation 1/1165 20/18722 0.72351683134735 0.815481922560779 EFNA1 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/1165 20/18722 0.72351683134735 0.815481922560779 PARK7 1 GO:1903817 negative regulation of voltage-gated potassium channel activity 1/1165 20/18722 0.72351683134735 0.815481922560779 ANK3 1 GO:1904263 positive regulation of TORC1 signaling 1/1165 20/18722 0.72351683134735 0.815481922560779 LAMTOR5 1 GO:1904292 regulation of ERAD pathway 1/1165 20/18722 0.72351683134735 0.815481922560779 USP14 1 GO:1990182 exosomal secretion 1/1165 20/18722 0.72351683134735 0.815481922560779 RAB11A 1 GO:0000070 mitotic sister chromatid segregation 9/1165 168/18722 0.725102401427295 0.817104954670027 DUSP1/RAN/ANAPC11/CENPF/NAA10/RAD21/RAB11A/SMC3/CCNB1 9 GO:0071103 DNA conformation change 16/1165 290/18722 0.726431749245125 0.818438660881752 MCM3/NASP/HELLS/NPM1/MCM6/MCM7/DHX36/DDX1/RUVBL1/RAD50/HMGB3/NAA10/SET/SSBP1/TOP2A/CCNB1 16 GO:0055092 sterol homeostasis 5/1165 97/18722 0.72906421151787 0.821239698825969 LRP5/CD24/LIMA1/APOE/MYLIP 5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 3/1165 60/18722 0.729914807926931 0.821867967280614 MBNL3/MBNL2/SRSF2 3 GO:0019731 antibacterial humoral response 3/1165 60/18722 0.729914807926931 0.821867967280614 HLA-A/HLA-E/DEFB1 3 GO:0006023 aminoglycan biosynthetic process 4/1165 79/18722 0.732463251812246 0.824572048219442 CHPF/CLTC/TGFB1/ST3GAL4 4 GO:0001953 negative regulation of cell-matrix adhesion 2/1165 41/18722 0.733258582946188 0.824640438003797 RASA1/LRP1 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/1165 41/18722 0.733258582946188 0.824640438003797 GSTO1/SLC8A1 2 GO:1903524 positive regulation of blood circulation 2/1165 41/18722 0.733258582946188 0.824640438003797 ADRB1/GCH1 2 GO:1905521 regulation of macrophage migration 2/1165 41/18722 0.733258582946188 0.824640438003797 CD9/TREM2 2 GO:2000008 regulation of protein localization to cell surface 2/1165 41/18722 0.733258582946188 0.824640438003797 TYROBP/HSP90AB1 2 GO:0016570 histone modification 26/1165 463/18722 0.73532102196845 0.826794250061881 ISL1/GATA3/DDB1/BRD4/TBL1X/DNMT1/VEGFA/MORF4L2/SPI1/USP22/RUVBL1/BRD7/SMYD2/NCOA3/PARK7/RTF1/HDAC2/MORF4L1/IGF2/PHB/UFL1/SET/PRMT1/JAK2/PHF20/CCNB1 26 GO:0090501 RNA phosphodiester bond hydrolysis 8/1165 152/18722 0.736331035526283 0.827746800076539 RPS21/RNASET2/REXO2/ISG20/NHP2/SND1/POLR2I/APEX1 8 GO:0048839 inner ear development 10/1165 188/18722 0.739709555791822 0.827746800076539 LGR5/ESRP1/GATA3/ATP6V1B1/TFAP2A/GLI3/SOD1/MYO7A/DLX5/TRIOBP 10 GO:0030199 collagen fibril organization 3/1165 61/18722 0.740195579510786 0.827746800076539 COL14A1/SERPINH1/P4HA1 3 GO:0050994 regulation of lipid catabolic process 3/1165 61/18722 0.740195579510786 0.827746800076539 IDH1/APOC1/SORL1 3 GO:0010878 cholesterol storage 1/1165 21/18722 0.740739742879825 0.827746800076539 TREM2 1 GO:0019985 translesion synthesis 1/1165 21/18722 0.740739742879825 0.827746800076539 VCP 1 GO:0022010 central nervous system myelination 1/1165 21/18722 0.740739742879825 0.827746800076539 TLR2 1 GO:0023019 signal transduction involved in regulation of gene expression 1/1165 21/18722 0.740739742879825 0.827746800076539 PARP1 1 GO:0030502 negative regulation of bone mineralization 1/1165 21/18722 0.740739742879825 0.827746800076539 SRGN 1 GO:0031145 anaphase-promoting complex-dependent catabolic process 1/1165 21/18722 0.740739742879825 0.827746800076539 ANAPC11 1 GO:0032291 axon ensheathment in central nervous system 1/1165 21/18722 0.740739742879825 0.827746800076539 TLR2 1 GO:0033962 P-body assembly 1/1165 21/18722 0.740739742879825 0.827746800076539 LSM3 1 GO:0034312 diol biosynthetic process 1/1165 21/18722 0.740739742879825 0.827746800076539 GCH1 1 GO:0035330 regulation of hippo signaling 1/1165 21/18722 0.740739742879825 0.827746800076539 DLG5 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/1165 21/18722 0.740739742879825 0.827746800076539 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/1165 21/18722 0.740739742879825 0.827746800076539 SLC5A3 1 GO:0044241 lipid digestion 1/1165 21/18722 0.740739742879825 0.827746800076539 LIMA1 1 GO:0046519 sphingoid metabolic process 1/1165 21/18722 0.740739742879825 0.827746800076539 PLPP3 1 GO:0046599 regulation of centriole replication 1/1165 21/18722 0.740739742879825 0.827746800076539 NPM1 1 GO:0048745 smooth muscle tissue development 1/1165 21/18722 0.740739742879825 0.827746800076539 DLG1 1 GO:0050802 circadian sleep/wake cycle, sleep 1/1165 21/18722 0.740739742879825 0.827746800076539 ADRB1 1 GO:0050849 negative regulation of calcium-mediated signaling 1/1165 21/18722 0.740739742879825 0.827746800076539 ATP2B4 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/1165 21/18722 0.740739742879825 0.827746800076539 SOD2 1 GO:0060972 left/right pattern formation 1/1165 21/18722 0.740739742879825 0.827746800076539 HSPB11 1 GO:0070269 pyroptosis 1/1165 21/18722 0.740739742879825 0.827746800076539 TREM2 1 GO:0097734 extracellular exosome biogenesis 1/1165 21/18722 0.740739742879825 0.827746800076539 RAB11A 1 GO:0098698 postsynaptic specialization assembly 1/1165 21/18722 0.740739742879825 0.827746800076539 ABI3 1 GO:0098856 intestinal lipid absorption 1/1165 21/18722 0.740739742879825 0.827746800076539 LIMA1 1 GO:1901863 positive regulation of muscle tissue development 1/1165 21/18722 0.740739742879825 0.827746800076539 IGF2 1 GO:1902644 tertiary alcohol metabolic process 1/1165 21/18722 0.740739742879825 0.827746800076539 AKR1B1 1 GO:2000291 regulation of myoblast proliferation 1/1165 21/18722 0.740739742879825 0.827746800076539 MALAT1 1 GO:0006813 potassium ion transport 13/1165 241/18722 0.741708719271766 0.828664618087664 GJA5/FXYD3/ANK3/KCNN4/SLC9A1/KCNG1/ITGB1/DLG1/FLNA/AKAP9/SLC1A3/TREM2/YWHAE 13 GO:0007631 feeding behavior 5/1165 99/18722 0.745339206033573 0.831155860819837 APP/FOS/EIF2AK4/GDF15/RETN 5 GO:0021510 spinal cord development 5/1165 99/18722 0.745339206033573 0.831155860819837 ISL1/LMO4/GLI3/PTN/SOX4 5 GO:0021549 cerebellum development 5/1165 99/18722 0.745339206033573 0.831155860819837 UQCRQ/AIF1/PTN/HSPA5/ATIC 5 GO:0000266 mitochondrial fission 2/1165 42/18722 0.745419312910575 0.831155860819837 FIS1/BNIP3 2 GO:0010591 regulation of lamellipodium assembly 2/1165 42/18722 0.745419312910575 0.831155860819837 WASF2/ABI3 2 GO:0043507 positive regulation of JUN kinase activity 2/1165 42/18722 0.745419312910575 0.831155860819837 RPS3/SYK 2 GO:0045292 mRNA cis splicing, via spliceosome 2/1165 42/18722 0.745419312910575 0.831155860819837 RBM17/SNRPC 2 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 2/1165 42/18722 0.745419312910575 0.831155860819837 RHOA/KLF4 2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 2/1165 42/18722 0.745419312910575 0.831155860819837 REXO2/ISG20 2 GO:1903432 regulation of TORC1 signaling 2/1165 42/18722 0.745419312910575 0.831155860819837 SESN1/LAMTOR5 2 GO:0007062 sister chromatid cohesion 3/1165 62/18722 0.750162978698886 0.835845331097584 NAA10/RAD21/SMC3 3 GO:0048663 neuron fate commitment 3/1165 62/18722 0.750162978698886 0.835845331097584 ISL1/ESRP1/GLI3 3 GO:0001523 retinoid metabolic process 4/1165 81/18722 0.750220698034852 0.835845331097584 LRP2/ADH5/AKR1B1/LRP1 4 GO:0051149 positive regulation of muscle cell differentiation 4/1165 81/18722 0.750220698034852 0.835845331097584 SOD2/MORF4L2/TGFB1/MDM2 4 GO:0034660 ncRNA metabolic process 27/1165 485/18722 0.7540625361678 0.83984353171499 LIN28B/RPS17/RPS21/KCNQ1OT1/MRPL1/IARS2/RPS27/PRKDC/RPS28/SNU13/DDX27/DDX1/PA2G4/RPS14/KRR1/RPL35/RPL5/ISG20/BRIX1/RPS7/HRAS/NHP2/RPS16/SND1/NOP56/IMP3/RPL10A 27 GO:0006379 mRNA cleavage 1/1165 22/18722 0.756890654571446 0.83984353171499 POLR2I 1 GO:0006662 glycerol ether metabolic process 1/1165 22/18722 0.756890654571446 0.83984353171499 TXN2 1 GO:0007398 ectoderm development 1/1165 22/18722 0.756890654571446 0.83984353171499 ITGA6 1 GO:0007413 axonal fasciculation 1/1165 22/18722 0.756890654571446 0.83984353171499 NRP1 1 GO:0031061 negative regulation of histone methylation 1/1165 22/18722 0.756890654571446 0.83984353171499 DNMT1 1 GO:0032098 regulation of appetite 1/1165 22/18722 0.756890654571446 0.83984353171499 NENF 1 GO:0032402 melanosome transport 1/1165 22/18722 0.756890654571446 0.83984353171499 RAB11A 1 GO:0042749 regulation of circadian sleep/wake cycle 1/1165 22/18722 0.756890654571446 0.83984353171499 ADRB1 1 GO:0043486 histone exchange 1/1165 22/18722 0.756890654571446 0.83984353171499 NASP 1 GO:0044346 fibroblast apoptotic process 1/1165 22/18722 0.756890654571446 0.83984353171499 STK17A 1 GO:0045048 protein insertion into ER membrane 1/1165 22/18722 0.756890654571446 0.83984353171499 CCDC47 1 GO:0090280 positive regulation of calcium ion import 1/1165 22/18722 0.756890654571446 0.83984353171499 LGALS3 1 GO:0097164 ammonium ion metabolic process 1/1165 22/18722 0.756890654571446 0.83984353171499 ALDH7A1 1 GO:0106030 neuron projection fasciculation 1/1165 22/18722 0.756890654571446 0.83984353171499 NRP1 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1165 22/18722 0.756890654571446 0.83984353171499 VEGFA 1 GO:2000193 positive regulation of fatty acid transport 1/1165 22/18722 0.756890654571446 0.83984353171499 PTGES 1 GO:2000725 regulation of cardiac muscle cell differentiation 1/1165 22/18722 0.756890654571446 0.83984353171499 TGFB1 1 GO:0021983 pituitary gland development 2/1165 43/18722 0.757101063687485 0.83984353171499 CDH1/ISL1 2 GO:0098815 modulation of excitatory postsynaptic potential 2/1165 43/18722 0.757101063687485 0.83984353171499 APP/PRKCZ 2 GO:0140353 lipid export from cell 2/1165 43/18722 0.757101063687485 0.83984353171499 PTGES/RETN 2 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/1165 43/18722 0.757101063687485 0.83984353171499 PRDX2/IFI6 2 GO:0007032 endosome organization 4/1165 82/18722 0.758753914039687 0.841178297354288 SNX10/VPS25/RAB11A/SNX3 4 GO:0046889 positive regulation of lipid biosynthetic process 4/1165 82/18722 0.758753914039687 0.841178297354288 SORBS1/APOE/CD74/CGA 4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 4/1165 82/18722 0.758753914039687 0.841178297354288 RPS21/RNASET2/SND1/APEX1 4 GO:0099601 regulation of neurotransmitter receptor activity 3/1165 63/18722 0.759821242508809 0.842195227922975 APP/IFNGR2/AKAP9 3 GO:0018105 peptidyl-serine phosphorylation 17/1165 315/18722 0.762364265122354 0.844847111575868 EGFR/APP/CD44/PRKCZ/TFRC/HSP90AB1/HSP90AA1/PRKDC/VEGFA/LATS2/TLK1/ATP2B4/AKAP9/TGFB1/PARK7/SYK/CCNB1 17 GO:0006378 mRNA polyadenylation 2/1165 44/18722 0.768316299672075 0.848031193167016 APP/PABPC1 2 GO:0006775 fat-soluble vitamin metabolic process 2/1165 44/18722 0.768316299672075 0.848031193167016 LRP2/LGMN 2 GO:0008542 visual learning 2/1165 44/18722 0.768316299672075 0.848031193167016 APP/ITGB1 2 GO:0032007 negative regulation of TOR signaling 2/1165 44/18722 0.768316299672075 0.848031193167016 SESN1/PDCD6 2 GO:0032620 interleukin-17 production 2/1165 44/18722 0.768316299672075 0.848031193167016 TGFB1/PHB 2 GO:0032660 regulation of interleukin-17 production 2/1165 44/18722 0.768316299672075 0.848031193167016 TGFB1/PHB 2 GO:1903214 regulation of protein targeting to mitochondrion 2/1165 44/18722 0.768316299672075 0.848031193167016 LMAN1/BNIP3L 2 GO:0034308 primary alcohol metabolic process 5/1165 102/18722 0.768378390929633 0.848031193167016 ACSS1/ADH5/AKR1B1/ALDH2/PARK7 5 GO:0006940 regulation of smooth muscle contraction 3/1165 64/18722 0.769174976292251 0.848031193167016 SOD1/ATP2B1/RHOA 3 GO:0017156 calcium-ion regulated exocytosis 3/1165 64/18722 0.769174976292251 0.848031193167016 SYT7/SCIN/GNAI2 3 GO:0030858 positive regulation of epithelial cell differentiation 3/1165 64/18722 0.769174976292251 0.848031193167016 CD24/NCOA3/BAD 3 GO:0046530 photoreceptor cell differentiation 3/1165 64/18722 0.769174976292251 0.848031193167016 MYO7A/PTN/VEGFA 3 GO:0046579 positive regulation of Ras protein signal transduction 3/1165 64/18722 0.769174976292251 0.848031193167016 ADGRG1/NET1/HRAS 3 GO:0046854 phosphatidylinositol phosphate biosynthetic process 3/1165 64/18722 0.769174976292251 0.848031193167016 PIK3C2A/TMEM150A/SOCS3 3 GO:0050771 negative regulation of axonogenesis 3/1165 64/18722 0.769174976292251 0.848031193167016 SEMA6A/SEMA6D/NRP1 3 GO:0098930 axonal transport 3/1165 64/18722 0.769174976292251 0.848031193167016 SOD1/ARMCX3/DST 3 GO:1903018 regulation of glycoprotein metabolic process 3/1165 64/18722 0.769174976292251 0.848031193167016 PAWR/ITM2C/CST3 3 GO:0001919 regulation of receptor recycling 1/1165 23/18722 0.772036236786647 0.848031193167016 NSG1 1 GO:0006833 water transport 1/1165 23/18722 0.772036236786647 0.848031193167016 AQP9 1 GO:0007130 synaptonemal complex assembly 1/1165 23/18722 0.772036236786647 0.848031193167016 RAD21 1 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 1/1165 23/18722 0.772036236786647 0.848031193167016 LRP1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/1165 23/18722 0.772036236786647 0.848031193167016 GSTP1 1 GO:0016578 histone deubiquitination 1/1165 23/18722 0.772036236786647 0.848031193167016 USP22 1 GO:0021544 subpallium development 1/1165 23/18722 0.772036236786647 0.848031193167016 GLI3 1 GO:0032401 establishment of melanosome localization 1/1165 23/18722 0.772036236786647 0.848031193167016 RAB11A 1 GO:0034695 response to prostaglandin E 1/1165 23/18722 0.772036236786647 0.848031193167016 TGFBR3 1 GO:0035929 steroid hormone secretion 1/1165 23/18722 0.772036236786647 0.848031193167016 RETN 1 GO:0035988 chondrocyte proliferation 1/1165 23/18722 0.772036236786647 0.848031193167016 GOLGB1 1 GO:0040019 positive regulation of embryonic development 1/1165 23/18722 0.772036236786647 0.848031193167016 AMOT 1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1/1165 23/18722 0.772036236786647 0.848031193167016 VPS25 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/1165 23/18722 0.772036236786647 0.848031193167016 CTSL 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/1165 23/18722 0.772036236786647 0.848031193167016 CD74 1 GO:0045724 positive regulation of cilium assembly 1/1165 23/18722 0.772036236786647 0.848031193167016 ATMIN 1 GO:0045932 negative regulation of muscle contraction 1/1165 23/18722 0.772036236786647 0.848031193167016 SOD1 1 GO:0045943 positive regulation of transcription by RNA polymerase I 1/1165 23/18722 0.772036236786647 0.848031193167016 NCL 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/1165 23/18722 0.772036236786647 0.848031193167016 CHPF 1 GO:0051383 kinetochore organization 1/1165 23/18722 0.772036236786647 0.848031193167016 CENPF 1 GO:0051457 maintenance of protein location in nucleus 1/1165 23/18722 0.772036236786647 0.848031193167016 PARK7 1 GO:0051590 positive regulation of neurotransmitter transport 1/1165 23/18722 0.772036236786647 0.848031193167016 ITGB1 1 GO:0060353 regulation of cell adhesion molecule production 1/1165 23/18722 0.772036236786647 0.848031193167016 COLEC12 1 GO:0071218 cellular response to misfolded protein 1/1165 23/18722 0.772036236786647 0.848031193167016 VCP 1 GO:0090335 regulation of brown fat cell differentiation 1/1165 23/18722 0.772036236786647 0.848031193167016 BMP7 1 GO:0140112 extracellular vesicle biogenesis 1/1165 23/18722 0.772036236786647 0.848031193167016 RAB11A 1 GO:1902410 mitotic cytokinetic process 1/1165 23/18722 0.772036236786647 0.848031193167016 RHOA 1 GO:2000737 negative regulation of stem cell differentiation 1/1165 23/18722 0.772036236786647 0.848031193167016 YAP1 1 GO:0002088 lens development in camera-type eye 4/1165 84/18722 0.775139796574684 0.851107135792977 GATA3/DLG1/VIM/SKIL 4 GO:0061157 mRNA destabilization 4/1165 84/18722 0.775139796574684 0.851107135792977 ZFP36/DHX36/PABPC1/ZFP36L1 4 GO:0031109 microtubule polymerization or depolymerization 6/1165 122/18722 0.778122008196886 0.853831118513468 MET/CLIP1/AKAP9/CIB1/STMN1/RPS3 6 GO:0051310 metaphase plate congression 3/1165 65/18722 0.778229111404757 0.853831118513468 CENPF/RAB11A/CCNB1 3 GO:0061512 protein localization to cilium 3/1165 65/18722 0.778229111404757 0.853831118513468 SNX10/ARF4/RABEP1 3 GO:0070936 protein K48-linked ubiquitination 3/1165 65/18722 0.778229111404757 0.853831118513468 SKP2/UBE2H/PPIA 3 GO:0006110 regulation of glycolytic process 2/1165 45/18722 0.779077789702485 0.854094459687509 APP/FBP1 2 GO:0032309 icosanoid secretion 2/1165 45/18722 0.779077789702485 0.854094459687509 PTGES/SYK 2 GO:0042551 neuron maturation 2/1165 45/18722 0.779077789702485 0.854094459687509 APP/C1QA 2 GO:0043631 RNA polyadenylation 2/1165 45/18722 0.779077789702485 0.854094459687509 APP/PABPC1 2 GO:0032006 regulation of TOR signaling 5/1165 104/18722 0.782835280145104 0.85804616821997 SLC38A9/SESN1/TREM2/LAMTOR5/PDCD6 5 GO:0000395 mRNA 5'-splice site recognition 1/1165 24/18722 0.786239016836038 0.859427381012791 SNRPC 1 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/1165 24/18722 0.786239016836038 0.859427381012791 RPS21 1 GO:0022410 circadian sleep/wake cycle process 1/1165 24/18722 0.786239016836038 0.859427381012791 ADRB1 1 GO:0030878 thyroid gland development 1/1165 24/18722 0.786239016836038 0.859427381012791 CGA 1 GO:0033032 regulation of myeloid cell apoptotic process 1/1165 24/18722 0.786239016836038 0.859427381012791 IRF7 1 GO:0051156 glucose 6-phosphate metabolic process 1/1165 24/18722 0.786239016836038 0.859427381012791 RPIA 1 GO:0051570 regulation of histone H3-K9 methylation 1/1165 24/18722 0.786239016836038 0.859427381012791 DNMT1 1 GO:0051923 sulfation 1/1165 24/18722 0.786239016836038 0.859427381012791 TPST2 1 GO:0060571 morphogenesis of an epithelial fold 1/1165 24/18722 0.786239016836038 0.859427381012791 BMP7 1 GO:0070935 3'-UTR-mediated mRNA stabilization 1/1165 24/18722 0.786239016836038 0.859427381012791 ZFP36 1 GO:0120255 olefinic compound biosynthetic process 1/1165 24/18722 0.786239016836038 0.859427381012791 HSD17B1 1 GO:1903861 positive regulation of dendrite extension 1/1165 24/18722 0.786239016836038 0.859427381012791 CXCR4 1 GO:2000209 regulation of anoikis 1/1165 24/18722 0.786239016836038 0.859427381012791 ITGB1 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/1165 24/18722 0.786239016836038 0.859427381012791 PDCD4 1 GO:0006303 double-strand break repair via nonhomologous end joining 3/1165 66/18722 0.786988865475159 0.859744745409121 PSMD14/PRKDC/PARP9 3 GO:0032715 negative regulation of interleukin-6 production 3/1165 66/18722 0.786988865475159 0.859744745409121 KLF2/PTPN6/LILRB4 3 GO:1902476 chloride transmembrane transport 3/1165 66/18722 0.786988865475159 0.859744745409121 SLC26A2/GABRE/SLC1A3 3 GO:0006984 ER-nucleus signaling pathway 2/1165 46/18722 0.789398521007478 0.861538770837055 HSPA5/CCDC47 2 GO:0007019 microtubule depolymerization 2/1165 46/18722 0.789398521007478 0.861538770837055 CIB1/STMN1 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/1165 46/18722 0.789398521007478 0.861538770837055 TENM3/CADM1 2 GO:0034198 cellular response to amino acid starvation 2/1165 46/18722 0.789398521007478 0.861538770837055 SESN1/EIF2AK4 2 GO:0044818 mitotic G2/M transition checkpoint 2/1165 46/18722 0.789398521007478 0.861538770837055 FOXO4/BABAM1 2 GO:0032413 negative regulation of ion transmembrane transporter activity 4/1165 86/18722 0.790635045187305 0.862720549890425 ANK3/C4orf3/GSTO1/YWHAE 4 GO:0006513 protein monoubiquitination 3/1165 67/18722 0.795459705192192 0.866560535266711 DDB1/UBB/PDCD6 3 GO:0009583 detection of light stimulus 3/1165 67/18722 0.795459705192192 0.866560535266711 GNA11/OPN3/NMT1 3 GO:0048814 regulation of dendrite morphogenesis 3/1165 67/18722 0.795459705192192 0.866560535266711 OBSL1/ID1/DHX36 3 GO:0061014 positive regulation of mRNA catabolic process 4/1165 87/18722 0.798055750721955 0.866560535266711 ZFP36/DHX36/PABPC1/ZFP36L1 4 GO:0032369 negative regulation of lipid transport 2/1165 47/18722 0.799291622668361 0.866560535266711 APOC1/FIS1 2 GO:0045601 regulation of endothelial cell differentiation 2/1165 47/18722 0.799291622668361 0.866560535266711 ID1/VEGFA 2 GO:0047496 vesicle transport along microtubule 2/1165 47/18722 0.799291622668361 0.866560535266711 PRKCZ/CLN3 2 GO:0090279 regulation of calcium ion import 2/1165 47/18722 0.799291622668361 0.866560535266711 LGALS3/VDAC1 2 GO:0101023 vascular endothelial cell proliferation 2/1165 47/18722 0.799291622668361 0.866560535266711 FLT1/IGF2 2 GO:0120163 negative regulation of cold-induced thermogenesis 2/1165 47/18722 0.799291622668361 0.866560535266711 LGR4/ID1 2 GO:1905562 regulation of vascular endothelial cell proliferation 2/1165 47/18722 0.799291622668361 0.866560535266711 FLT1/IGF2 2 GO:0006312 mitotic recombination 1/1165 25/18722 0.799557636227738 0.866560535266711 RAD50 1 GO:0010560 positive regulation of glycoprotein biosynthetic process 1/1165 25/18722 0.799557636227738 0.866560535266711 PAWR 1 GO:0015012 heparan sulfate proteoglycan biosynthetic process 1/1165 25/18722 0.799557636227738 0.866560535266711 EXTL2 1 GO:0015874 norepinephrine transport 1/1165 25/18722 0.799557636227738 0.866560535266711 ACTB 1 GO:0032104 regulation of response to extracellular stimulus 1/1165 25/18722 0.799557636227738 0.866560535266711 NENF 1 GO:0032107 regulation of response to nutrient levels 1/1165 25/18722 0.799557636227738 0.866560535266711 NENF 1 GO:0032331 negative regulation of chondrocyte differentiation 1/1165 25/18722 0.799557636227738 0.866560535266711 EFEMP1 1 GO:0032400 melanosome localization 1/1165 25/18722 0.799557636227738 0.866560535266711 RAB11A 1 GO:0034389 lipid droplet organization 1/1165 25/18722 0.799557636227738 0.866560535266711 PPIA 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/1165 25/18722 0.799557636227738 0.866560535266711 TECR 1 GO:0036315 cellular response to sterol 1/1165 25/18722 0.799557636227738 0.866560535266711 DAG1 1 GO:0045324 late endosome to vacuole transport 1/1165 25/18722 0.799557636227738 0.866560535266711 VPS25 1 GO:0045822 negative regulation of heart contraction 1/1165 25/18722 0.799557636227738 0.866560535266711 JAK2 1 GO:0050927 positive regulation of positive chemotaxis 1/1165 25/18722 0.799557636227738 0.866560535266711 VEGFA 1 GO:0051307 meiotic chromosome separation 1/1165 25/18722 0.799557636227738 0.866560535266711 TOP2A 1 GO:0051788 response to misfolded protein 1/1165 25/18722 0.799557636227738 0.866560535266711 VCP 1 GO:0060740 prostate gland epithelium morphogenesis 1/1165 25/18722 0.799557636227738 0.866560535266711 BMP7 1 GO:0070199 establishment of protein localization to chromosome 1/1165 25/18722 0.799557636227738 0.866560535266711 CCT2 1 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 1/1165 25/18722 0.799557636227738 0.866560535266711 NFKBIA 1 GO:0090312 positive regulation of protein deacetylation 1/1165 25/18722 0.799557636227738 0.866560535266711 VEGFA 1 GO:1904385 cellular response to angiotensin 1/1165 25/18722 0.799557636227738 0.866560535266711 CYBA 1 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 1/1165 25/18722 0.799557636227738 0.866560535266711 RHOA 1 GO:1905563 negative regulation of vascular endothelial cell proliferation 1/1165 25/18722 0.799557636227738 0.866560535266711 FLT1 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/1165 25/18722 0.799557636227738 0.866560535266711 IGF2 1 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 5/1165 107/18722 0.803197681517314 0.870337564933722 LAPTM5/MAGEF1/VCP/DAB2/MDM2 5 GO:0031929 TOR signaling 6/1165 126/18722 0.803453541411251 0.870446772426434 GATA3/SLC38A9/SESN1/TREM2/LAMTOR5/PDCD6 6 GO:0061912 selective autophagy 3/1165 68/18722 0.803647311521198 0.870488683822556 SLC25A5/UFL1/VDAC1 3 GO:0071805 potassium ion transmembrane transport 11/1165 219/18722 0.808388589781596 0.873518652196636 ANK3/KCNN4/SLC9A1/KCNG1/ITGB1/DLG1/FLNA/AKAP9/SLC1A3/TREM2/YWHAE 11 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 14/1165 273/18722 0.808678232353199 0.873518652196636 TENM3/CDH1/CLDN4/DSG2/DSC3/CADM1/DSC2/OBSL1/ITGB1/BSG/CLDN7/FXYD5/PECAM1/KLF4 14 GO:0015804 neutral amino acid transport 2/1165 48/18722 0.808770297745962 0.873518652196636 SLC38A1/SLC38A9 2 GO:0030261 chromosome condensation 2/1165 48/18722 0.808770297745962 0.873518652196636 TOP2A/CCNB1 2 GO:0042908 xenobiotic transport 2/1165 48/18722 0.808770297745962 0.873518652196636 SLC2A1/GJA1 2 GO:0061647 histone H3-K9 modification 2/1165 48/18722 0.808770297745962 0.873518652196636 GATA3/DNMT1 2 GO:0090311 regulation of protein deacetylation 2/1165 48/18722 0.808770297745962 0.873518652196636 BEX4/VEGFA 2 GO:0120009 intermembrane lipid transfer 2/1165 48/18722 0.808770297745962 0.873518652196636 APOE/TSPO 2 GO:0009952 anterior/posterior pattern specification 10/1165 201/18722 0.809143409148546 0.873518652196636 NR2F2/PBX1/WLS/LRP5/GLI3/GPC3/TBX3/PRKDC/BASP1/BHLHE41 10 GO:0022037 metencephalon development 5/1165 108/18722 0.809639882566084 0.873518652196636 UQCRQ/AIF1/PTN/HSPA5/ATIC 5 GO:0003143 embryonic heart tube morphogenesis 3/1165 69/18722 0.811557547260445 0.873518652196636 FOLR1/TBX3/YAP1 3 GO:0051966 regulation of synaptic transmission, glutamatergic 3/1165 69/18722 0.811557547260445 0.873518652196636 EGFR/GLUL/CLN3 3 GO:0070192 chromosome organization involved in meiotic cell cycle 3/1165 69/18722 0.811557547260445 0.873518652196636 CCNE1/RAD50/RAD21 3 GO:0001556 oocyte maturation 1/1165 26/18722 0.81204709195832 0.873518652196636 CCNB1 1 GO:0001573 ganglioside metabolic process 1/1165 26/18722 0.81204709195832 0.873518652196636 ITGB8 1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1/1165 26/18722 0.81204709195832 0.873518652196636 SRP14 1 GO:0015985 energy coupled proton transport, down electrochemical gradient 1/1165 26/18722 0.81204709195832 0.873518652196636 STOML2 1 GO:0015986 ATP synthesis coupled proton transport 1/1165 26/18722 0.81204709195832 0.873518652196636 STOML2 1 GO:0018027 peptidyl-lysine dimethylation 1/1165 26/18722 0.81204709195832 0.873518652196636 SMYD2 1 GO:0021952 central nervous system projection neuron axonogenesis 1/1165 26/18722 0.81204709195832 0.873518652196636 C12orf57 1 GO:0033522 histone H2A ubiquitination 1/1165 26/18722 0.81204709195832 0.873518652196636 DDB1 1 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 1/1165 26/18722 0.81204709195832 0.873518652196636 NFKBIA 1 GO:0042537 benzene-containing compound metabolic process 1/1165 26/18722 0.81204709195832 0.873518652196636 KYNU 1 GO:0042634 regulation of hair cycle 1/1165 26/18722 0.81204709195832 0.873518652196636 FERMT1 1 GO:0043501 skeletal muscle adaptation 1/1165 26/18722 0.81204709195832 0.873518652196636 CAMK2G 1 GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 1/1165 26/18722 0.81204709195832 0.873518652196636 PHB 1 GO:0046639 negative regulation of alpha-beta T cell differentiation 1/1165 26/18722 0.81204709195832 0.873518652196636 GLI3 1 GO:0050926 regulation of positive chemotaxis 1/1165 26/18722 0.81204709195832 0.873518652196636 VEGFA 1 GO:0060219 camera-type eye photoreceptor cell differentiation 1/1165 26/18722 0.81204709195832 0.873518652196636 PTN 1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 1/1165 26/18722 0.81204709195832 0.873518652196636 GSTO1 1 GO:0070193 synaptonemal complex organization 1/1165 26/18722 0.81204709195832 0.873518652196636 RAD21 1 GO:1901071 glucosamine-containing compound metabolic process 1/1165 26/18722 0.81204709195832 0.873518652196636 EXTL2 1 GO:1902186 regulation of viral release from host cell 1/1165 26/18722 0.81204709195832 0.873518652196636 DDB1 1 GO:1903523 negative regulation of blood circulation 1/1165 26/18722 0.81204709195832 0.873518652196636 JAK2 1 GO:1904861 excitatory synapse assembly 1/1165 26/18722 0.81204709195832 0.873518652196636 ABI3 1 GO:1905523 positive regulation of macrophage migration 1/1165 26/18722 0.81204709195832 0.873518652196636 TREM2 1 GO:0007286 spermatid development 8/1165 165/18722 0.812749482783789 0.874106696084577 JAM3/SLIRP/SMARCA2/PITHD1/CIB1/DLD/CDYL/DEFB1 8 GO:0000819 sister chromatid segregation 10/1165 202/18722 0.813855798034393 0.874961232401273 DUSP1/RAN/ANAPC11/CENPF/NAA10/RAD21/RAB11A/TOP2A/SMC3/CCNB1 10 GO:0017157 regulation of exocytosis 10/1165 202/18722 0.813855798034393 0.874961232401273 EXPH5/SYT7/STXBP2/HLA-F/SPI1/FGR/GNAI2/SYK/CD300A/LYN 10 GO:0032410 negative regulation of transporter activity 5/1165 109/18722 0.8159129499468 0.876993427438202 ANK3/NDFIP2/C4orf3/GSTO1/YWHAE 5 GO:0007059 chromosome segregation 18/1165 346/18722 0.816058555408824 0.876993427438202 BEX4/DUSP1/CCNE1/SLC25A5/TLK1/PLSCR1/RAN/ANAPC11/MKI67/CENPF/NAA10/PMF1/RAD21/RAB11A/RPS3/TOP2A/SMC3/CCNB1 18 GO:0006376 mRNA splice site selection 2/1165 49/18722 0.817847763292125 0.877404337797917 SF1/SNRPC 2 GO:0008206 bile acid metabolic process 2/1165 49/18722 0.817847763292125 0.877404337797917 SLC27A2/OSBPL9 2 GO:0009994 oocyte differentiation 2/1165 49/18722 0.817847763292125 0.877404337797917 LGR5/CCNB1 2 GO:0021695 cerebellar cortex development 2/1165 49/18722 0.817847763292125 0.877404337797917 UQCRQ/HSPA5 2 GO:0030195 negative regulation of blood coagulation 2/1165 49/18722 0.817847763292125 0.877404337797917 APOE/CD9 2 GO:0042461 photoreceptor cell development 2/1165 49/18722 0.817847763292125 0.877404337797917 MYO7A/VEGFA 2 GO:0046605 regulation of centrosome cycle 2/1165 49/18722 0.817847763292125 0.877404337797917 NPM1/ATF5 2 GO:0051932 synaptic transmission, GABAergic 2/1165 49/18722 0.817847763292125 0.877404337797917 GABRE/CLN3 2 GO:1990928 response to amino acid starvation 2/1165 49/18722 0.817847763292125 0.877404337797917 SESN1/EIF2AK4 2 GO:0048477 oogenesis 4/1165 90/18722 0.819048315721825 0.878524402091841 LGR5/ASPM/PTN/CCNB1 4 GO:0007127 meiosis I 6/1165 129/18722 0.820934681020809 0.879208796041127 CCNE1/UBB/RAD50/CKS2/RAD21/TOP2A 6 GO:0007389 pattern specification process 23/1165 436/18722 0.822737329437628 0.879208796041127 LRP2/ADGRG1/NR2F2/PBX1/BMP7/WLS/LRP5/ISL1/NRP2/FOLR1/GLI3/IRX2/GALNT11/GPC3/TBX3/NRP1/C1QA/AP1B1/PRKDC/PRKACB/HSPB11/BASP1/BHLHE41 23 GO:0000737 DNA catabolic process, endonucleolytic 1/1165 27/18722 0.823758962832761 0.879208796041127 APEX1 1 GO:0001958 endochondral ossification 1/1165 27/18722 0.823758962832761 0.879208796041127 DLX5 1 GO:0002227 innate immune response in mucosa 1/1165 27/18722 0.823758962832761 0.879208796041127 DEFB1 1 GO:0002825 regulation of T-helper 1 type immune response 1/1165 27/18722 0.823758962832761 0.879208796041127 SLC11A1 1 GO:0003401 axis elongation 1/1165 27/18722 0.823758962832761 0.879208796041127 YAP1 1 GO:0007026 negative regulation of microtubule depolymerization 1/1165 27/18722 0.823758962832761 0.879208796041127 CIB1 1 GO:0010528 regulation of transposition 1/1165 27/18722 0.823758962832761 0.879208796041127 APOBEC3A 1 GO:0010529 negative regulation of transposition 1/1165 27/18722 0.823758962832761 0.879208796041127 APOBEC3A 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/1165 27/18722 0.823758962832761 0.879208796041127 ITM2C 1 GO:0014850 response to muscle activity 1/1165 27/18722 0.823758962832761 0.879208796041127 FIS1 1 GO:0016556 mRNA modification 1/1165 27/18722 0.823758962832761 0.879208796041127 ZC3H13 1 GO:0018904 ether metabolic process 1/1165 27/18722 0.823758962832761 0.879208796041127 TXN2 1 GO:0034505 tooth mineralization 1/1165 27/18722 0.823758962832761 0.879208796041127 TFAP2A 1 GO:0036075 replacement ossification 1/1165 27/18722 0.823758962832761 0.879208796041127 DLX5 1 GO:0042745 circadian sleep/wake cycle 1/1165 27/18722 0.823758962832761 0.879208796041127 ADRB1 1 GO:0045606 positive regulation of epidermal cell differentiation 1/1165 27/18722 0.823758962832761 0.879208796041127 NCOA3 1 GO:0046337 phosphatidylethanolamine metabolic process 1/1165 27/18722 0.823758962832761 0.879208796041127 PISD 1 GO:0048873 homeostasis of number of cells within a tissue 1/1165 27/18722 0.823758962832761 0.879208796041127 LIPA 1 GO:0051953 negative regulation of amine transport 1/1165 27/18722 0.823758962832761 0.879208796041127 ARL6IP5 1 GO:0070861 regulation of protein exit from endoplasmic reticulum 1/1165 27/18722 0.823758962832761 0.879208796041127 SORL1 1 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 1/1165 27/18722 0.823758962832761 0.879208796041127 SEMA6A 1 GO:1903859 regulation of dendrite extension 1/1165 27/18722 0.823758962832761 0.879208796041127 CXCR4 1 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 1/1165 27/18722 0.823758962832761 0.879208796041127 PARP1 1 GO:2000463 positive regulation of excitatory postsynaptic potential 1/1165 27/18722 0.823758962832761 0.879208796041127 PRKCZ 1 GO:0019935 cyclic-nucleotide-mediated signaling 4/1165 91/18722 0.825634079800326 0.880033745375661 GNAI1/NUDT4/APOE/DEFB1 4 GO:0007080 mitotic metaphase plate congression 2/1165 50/18722 0.826537197528671 0.880033745375661 RAB11A/CCNB1 2 GO:0007632 visual behavior 2/1165 50/18722 0.826537197528671 0.880033745375661 APP/ITGB1 2 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/1165 50/18722 0.826537197528671 0.880033745375661 BNIP3/JAK2 2 GO:0015872 dopamine transport 2/1165 50/18722 0.826537197528671 0.880033745375661 SYT7/PARK7 2 GO:0018023 peptidyl-lysine trimethylation 2/1165 50/18722 0.826537197528671 0.880033745375661 BRD4/RTF1 2 GO:0038202 TORC1 signaling 2/1165 50/18722 0.826537197528671 0.880033745375661 SESN1/LAMTOR5 2 GO:0071709 membrane assembly 2/1165 50/18722 0.826537197528671 0.880033745375661 ANK3/S100A10 2 GO:1900047 negative regulation of hemostasis 2/1165 50/18722 0.826537197528671 0.880033745375661 APOE/CD9 2 GO:1901570 fatty acid derivative biosynthetic process 2/1165 50/18722 0.826537197528671 0.880033745375661 TECR/SLC25A1 2 GO:1902930 regulation of alcohol biosynthetic process 2/1165 50/18722 0.826537197528671 0.880033745375661 SOD1/APOE 2 GO:1904036 negative regulation of epithelial cell apoptotic process 2/1165 50/18722 0.826537197528671 0.880033745375661 GATA3/YAP1 2 GO:0008344 adult locomotory behavior 3/1165 71/18722 0.826570088298679 0.880033745375661 APP/EPS8/PARK7 3 GO:0006661 phosphatidylinositol biosynthetic process 6/1165 131/18722 0.831888942202059 0.885528661593051 PGAP2/SH3YL1/GPAA1/PIK3C2A/TMEM150A/SOCS3 6 GO:0090305 nucleic acid phosphodiester bond hydrolysis 13/1165 261/18722 0.83259688559409 0.886114205316577 RPS21/RNASET2/ZFP36/REXO2/PLSCR1/DDX1/ISG20/RAD50/NHP2/SND1/POLR2I/APEX1/PNRC2 13 GO:0003156 regulation of animal organ formation 1/1165 28/18722 0.834741621741552 0.886664627400914 BMP7 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/1165 28/18722 0.834741621741552 0.886664627400914 VCP 1 GO:0007141 male meiosis I 1/1165 28/18722 0.834741621741552 0.886664627400914 UBB 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/1165 28/18722 0.834741621741552 0.886664627400914 LRP1 1 GO:0007271 synaptic transmission, cholinergic 1/1165 28/18722 0.834741621741552 0.886664627400914 APOE 1 GO:0045686 negative regulation of glial cell differentiation 1/1165 28/18722 0.834741621741552 0.886664627400914 TREM2 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/1165 28/18722 0.834741621741552 0.886664627400914 SOCS3 1 GO:0071280 cellular response to copper ion 1/1165 28/18722 0.834741621741552 0.886664627400914 APP 1 GO:1903020 positive regulation of glycoprotein metabolic process 1/1165 28/18722 0.834741621741552 0.886664627400914 PAWR 1 GO:0051293 establishment of spindle localization 2/1165 51/18722 0.834851693535334 0.886664627400914 GJA1/ITGB1 2 GO:0060632 regulation of microtubule-based movement 2/1165 51/18722 0.834851693535334 0.886664627400914 DEFB1/CATSPER1 2 GO:0006887 exocytosis 18/1165 352/18722 0.836710897493606 0.888471106248885 EXPH5/SYT7/SCIN/ANXA3/STXBP2/HLA-F/S100A13/RAB25/SPI1/PIK3C2A/HCK/MYO1G/FGR/GNAI2/RAB11A/SYK/CD300A/LYN 18 GO:0006836 neurotransmitter transport 10/1165 208/18722 0.840307015256877 0.891869383067385 SLC6A4/SLC38A1/SYT7/STXBP2/ITGB1/PNKD/SLC1A3/SLC29A1/PARK7/NR4A1 10 GO:0051937 catecholamine transport 3/1165 73/18722 0.840546772924722 0.891869383067385 SYT7/PARK7/ACTB 3 GO:0061035 regulation of cartilage development 3/1165 73/18722 0.840546772924722 0.891869383067385 EFEMP1/GLI3/SCIN 3 GO:0070988 demethylation 3/1165 73/18722 0.840546772924722 0.891869383067385 GATA3/APOBEC3A/APEX1 3 GO:0007129 homologous chromosome pairing at meiosis 2/1165 52/18722 0.8428042188423 0.894095649284035 CCNE1/RAD21 2 GO:0006656 phosphatidylcholine biosynthetic process 1/1165 29/18722 0.845040434765575 0.894439366460338 SLC44A2 1 GO:0010390 histone monoubiquitination 1/1165 29/18722 0.845040434765575 0.894439366460338 DDB1 1 GO:0010458 exit from mitosis 1/1165 29/18722 0.845040434765575 0.894439366460338 EPS8 1 GO:0010592 positive regulation of lamellipodium assembly 1/1165 29/18722 0.845040434765575 0.894439366460338 WASF2 1 GO:0010955 negative regulation of protein processing 1/1165 29/18722 0.845040434765575 0.894439366460338 MDM2 1 GO:0032366 intracellular sterol transport 1/1165 29/18722 0.845040434765575 0.894439366460338 SYT7 1 GO:0032367 intracellular cholesterol transport 1/1165 29/18722 0.845040434765575 0.894439366460338 SYT7 1 GO:0032372 negative regulation of sterol transport 1/1165 29/18722 0.845040434765575 0.894439366460338 APOC1 1 GO:0032375 negative regulation of cholesterol transport 1/1165 29/18722 0.845040434765575 0.894439366460338 APOC1 1 GO:0043153 entrainment of circadian clock by photoperiod 1/1165 29/18722 0.845040434765575 0.894439366460338 NR2F6 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/1165 29/18722 0.845040434765575 0.894439366460338 ANK3 1 GO:1903318 negative regulation of protein maturation 1/1165 29/18722 0.845040434765575 0.894439366460338 MDM2 1 GO:0048515 spermatid differentiation 8/1165 172/18722 0.846235273721468 0.895535179373793 JAM3/SLIRP/SMARCA2/PITHD1/CIB1/DLD/CDYL/DEFB1 8 GO:0046470 phosphatidylcholine metabolic process 3/1165 74/18722 0.847162465946022 0.896178462373732 DBI/SLC44A2/APOC1 3 GO:1901568 fatty acid derivative metabolic process 3/1165 74/18722 0.847162465946022 0.896178462373732 HPGD/TECR/SLC25A1 3 GO:0034968 histone lysine methylation 5/1165 115/18722 0.850132539259634 0.89893366264272 GATA3/BRD4/DNMT1/SMYD2/RTF1 5 GO:0032210 regulation of telomere maintenance via telomerase 2/1165 53/18722 0.850407580372856 0.89893366264272 PKIB/CCT2 2 GO:0050819 negative regulation of coagulation 2/1165 53/18722 0.850407580372856 0.89893366264272 APOE/CD9 2 GO:0071715 icosanoid transport 2/1165 53/18722 0.850407580372856 0.89893366264272 PTGES/SYK 2 GO:0061982 meiosis I cell cycle process 6/1165 135/18722 0.852181556421256 0.900639253660801 CCNE1/UBB/RAD50/CKS2/RAD21/TOP2A 6 GO:0046474 glycerophospholipid biosynthetic process 10/1165 211/18722 0.852391632882721 0.900691685875511 PGAP2/SH3YL1/PISD/GPAA1/SLC44A2/PLSCR1/PIK3C2A/TMEM150A/CLN3/SOCS3 10 GO:0016197 endosomal transport 11/1165 230/18722 0.853981673218324 0.901262367406673 TINAGL1/NSG1/RHOBTB3/VCP/CLTC/VPS25/ARL1/SNX6/RAB11A/SNX3/SORL1 11 GO:0003299 muscle hypertrophy in response to stress 1/1165 30/18722 0.85469794792548 0.901262367406673 ATP2B4 1 GO:0008209 androgen metabolic process 1/1165 30/18722 0.85469794792548 0.901262367406673 HSD17B11 1 GO:0014887 cardiac muscle adaptation 1/1165 30/18722 0.85469794792548 0.901262367406673 ATP2B4 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/1165 30/18722 0.85469794792548 0.901262367406673 ATP2B4 1 GO:0030204 chondroitin sulfate metabolic process 1/1165 30/18722 0.85469794792548 0.901262367406673 CHPF 1 GO:0034694 response to prostaglandin 1/1165 30/18722 0.85469794792548 0.901262367406673 TGFBR3 1 GO:0045948 positive regulation of translational initiation 1/1165 30/18722 0.85469794792548 0.901262367406673 EIF2AK4 1 GO:0060292 long-term synaptic depression 1/1165 30/18722 0.85469794792548 0.901262367406673 LILRB2 1 GO:0060351 cartilage development involved in endochondral bone morphogenesis 1/1165 30/18722 0.85469794792548 0.901262367406673 SERPINH1 1 GO:0099068 postsynapse assembly 1/1165 30/18722 0.85469794792548 0.901262367406673 ABI3 1 GO:0006665 sphingolipid metabolic process 7/1165 155/18722 0.855309705732987 0.901738050014887 HACD3/PLPP3/ITGB8/DEGS1/ORMDL1/SERINC2/TECR 7 GO:0055017 cardiac muscle tissue growth 4/1165 96/18722 0.855640927301704 0.901917845059993 TGFBR3/GJA1/YAP1/CCNB1 4 GO:0099024 plasma membrane invagination 6/1165 136/18722 0.856929257683727 0.903043776927466 AIF1/RHOA/RHOBTB1/TREM2/RHOG/CD300A 6 GO:0007215 glutamate receptor signaling pathway 2/1165 54/18722 0.857674394227743 0.903043776927466 APP/CLN3 2 GO:0010524 positive regulation of calcium ion transport into cytosol 2/1165 54/18722 0.857674394227743 0.903043776927466 GSTO1/CXCL10 2 GO:0010659 cardiac muscle cell apoptotic process 2/1165 54/18722 0.857674394227743 0.903043776927466 BNIP3/JAK2 2 GO:0014888 striated muscle adaptation 2/1165 54/18722 0.857674394227743 0.903043776927466 CAMK2G/ATP2B4 2 GO:0060350 endochondral bone morphogenesis 2/1165 54/18722 0.857674394227743 0.903043776927466 SERPINH1/DLX5 2 GO:0071426 ribonucleoprotein complex export from nucleus 3/1165 76/18722 0.859680493121052 0.904816540012838 NPM1/RAN/NUP214 3 GO:0140029 exocytic process 3/1165 76/18722 0.859680493121052 0.904816540012838 STXBP2/SYK/LYN 3 GO:0043583 ear development 10/1165 213/18722 0.860039859724158 0.905025071734476 LGR5/ESRP1/GATA3/ATP6V1B1/TFAP2A/GLI3/SOD1/MYO7A/DLX5/TRIOBP 10 GO:0034754 cellular hormone metabolic process 6/1165 137/18722 0.861550808102348 0.906445114503932 HSD17B1/COMT/AKR1B1/IL4I1/HSD17B11/TSPO 6 GO:0002323 natural killer cell activation involved in immune response 1/1165 31/18722 0.863754062341637 0.90689329441145 HLA-F 1 GO:0006301 postreplication repair 1/1165 31/18722 0.863754062341637 0.90689329441145 VCP 1 GO:0031063 regulation of histone deacetylation 1/1165 31/18722 0.863754062341637 0.90689329441145 VEGFA 1 GO:0031114 regulation of microtubule depolymerization 1/1165 31/18722 0.863754062341637 0.90689329441145 CIB1 1 GO:0045987 positive regulation of smooth muscle contraction 1/1165 31/18722 0.863754062341637 0.90689329441145 RHOA 1 GO:0048566 embryonic digestive tract development 1/1165 31/18722 0.863754062341637 0.90689329441145 GLI3 1 GO:0050482 arachidonic acid secretion 1/1165 31/18722 0.863754062341637 0.90689329441145 SYK 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/1165 31/18722 0.863754062341637 0.90689329441145 GJA1 1 GO:0055075 potassium ion homeostasis 1/1165 31/18722 0.863754062341637 0.90689329441145 ATP6V1B1 1 GO:0061117 negative regulation of heart growth 1/1165 31/18722 0.863754062341637 0.90689329441145 GJA1 1 GO:1903963 arachidonate transport 1/1165 31/18722 0.863754062341637 0.90689329441145 SYK 1 GO:0002067 glandular epithelial cell differentiation 2/1165 55/18722 0.864617059845235 0.907459902189847 CDK6/BAD 2 GO:0044091 membrane biogenesis 2/1165 55/18722 0.864617059845235 0.907459902189847 ANK3/S100A10 2 GO:0071166 ribonucleoprotein complex localization 3/1165 77/18722 0.865595630580489 0.908147341018371 NPM1/RAN/NUP214 3 GO:0140056 organelle localization by membrane tethering 3/1165 77/18722 0.865595630580489 0.908147341018371 STXBP2/VMP1/CLN3 3 GO:0007224 smoothened signaling pathway 6/1165 138/18722 0.866048290533805 0.908452449031256 DLG5/GLI3/GPC3/VCP/PRKACB/HSPB11 6 GO:0043470 regulation of carbohydrate catabolic process 2/1165 56/18722 0.871247738110178 0.911886368469258 APP/FBP1 2 GO:0098781 ncRNA transcription 2/1165 56/18722 0.871247738110178 0.911886368469258 POLR2L/NCL 2 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 3/1165 78/18722 0.871290029301618 0.911886368469258 GNAI1/FLNA/GNAI2 3 GO:0035050 embryonic heart tube development 3/1165 78/18722 0.871290029301618 0.911886368469258 FOLR1/TBX3/YAP1 3 GO:0061045 negative regulation of wound healing 3/1165 78/18722 0.871290029301618 0.911886368469258 GJA1/APOE/CD9 3 GO:0015837 amine transport 4/1165 99/18722 0.871448110387525 0.911886368469258 SYT7/ITGB1/ARL6IP5/AQP9 4 GO:0051153 regulation of striated muscle cell differentiation 4/1165 99/18722 0.871448110387525 0.911886368469258 MORF4L2/TGFB1/BHLHE41/YBX1 4 GO:0006335 DNA replication-dependent nucleosome assembly 1/1165 32/18722 0.872246198523329 0.911886368469258 NASP 1 GO:0008156 negative regulation of DNA replication 1/1165 32/18722 0.872246198523329 0.911886368469258 GMNN 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/1165 32/18722 0.872246198523329 0.911886368469258 JAK2 1 GO:0010743 regulation of macrophage derived foam cell differentiation 1/1165 32/18722 0.872246198523329 0.911886368469258 NFKBIA 1 GO:0019228 neuronal action potential 1/1165 32/18722 0.872246198523329 0.911886368469258 ANK3 1 GO:0019934 cGMP-mediated signaling 1/1165 32/18722 0.872246198523329 0.911886368469258 APOE 1 GO:0034723 DNA replication-dependent nucleosome organization 1/1165 32/18722 0.872246198523329 0.911886368469258 NASP 1 GO:0042044 fluid transport 1/1165 32/18722 0.872246198523329 0.911886368469258 AQP9 1 GO:0045684 positive regulation of epidermis development 1/1165 32/18722 0.872246198523329 0.911886368469258 NCOA3 1 GO:0061036 positive regulation of cartilage development 1/1165 32/18722 0.872246198523329 0.911886368469258 GLI3 1 GO:0061037 negative regulation of cartilage development 1/1165 32/18722 0.872246198523329 0.911886368469258 EFEMP1 1 GO:0032259 methylation 18/1165 364/18722 0.872757600964082 0.912251101342903 GATA3/PARP1/HELLS/BRD4/COMT/DNMT1/FOS/DNMT3A/MTR/SPI1/SMYD2/RTF1/TYMS/RNMT/SNRPD3/ZC3H13/MBD2/PRMT1 18 GO:0006338 chromatin remodeling 12/1165 255/18722 0.875982597358512 0.915451558177868 SMARCA1/GATA3/NASP/HELLS/NPM1/SMARCA2/RUVBL1/HDAC2/SET/NUDT5/ACTB/MBD2 12 GO:0051155 positive regulation of striated muscle cell differentiation 2/1165 57/18722 0.877578333021289 0.916777811883211 MORF4L2/TGFB1 2 GO:1902017 regulation of cilium assembly 2/1165 57/18722 0.877578333021289 0.916777811883211 YAP1/ATMIN 2 GO:0007033 vacuole organization 8/1165 180/18722 0.878476865812412 0.916966526621969 SYT7/LAPTM5/MYO7A/VMP1/TMEM165/CLN3/GABARAPL1/GRN 8 GO:0016571 histone methylation 6/1165 141/18722 0.878817598980984 0.916966526621969 GATA3/BRD4/DNMT1/SMYD2/RTF1/PRMT1 6 GO:0006336 DNA replication-independent nucleosome assembly 1/1165 33/18722 0.880209450461281 0.916966526621969 NASP 1 GO:0009648 photoperiodism 1/1165 33/18722 0.880209450461281 0.916966526621969 NR2F6 1 GO:0018345 protein palmitoylation 1/1165 33/18722 0.880209450461281 0.916966526621969 GLUL 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/1165 33/18722 0.880209450461281 0.916966526621969 PDCD6 1 GO:0032228 regulation of synaptic transmission, GABAergic 1/1165 33/18722 0.880209450461281 0.916966526621969 CLN3 1 GO:0040020 regulation of meiotic nuclear division 1/1165 33/18722 0.880209450461281 0.916966526621969 CALR 1 GO:0046320 regulation of fatty acid oxidation 1/1165 33/18722 0.880209450461281 0.916966526621969 ACADVL 1 GO:0048730 epidermis morphogenesis 1/1165 33/18722 0.880209450461281 0.916966526621969 KLF4 1 GO:0050974 detection of mechanical stimulus involved in sensory perception 1/1165 33/18722 0.880209450461281 0.916966526621969 CXCR4 1 GO:0099174 regulation of presynapse organization 1/1165 33/18722 0.880209450461281 0.916966526621969 APP 1 GO:0110110 positive regulation of animal organ morphogenesis 1/1165 33/18722 0.880209450461281 0.916966526621969 GATA3 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/1165 33/18722 0.880209450461281 0.916966526621969 ANK3 1 GO:1905606 regulation of presynapse assembly 1/1165 33/18722 0.880209450461281 0.916966526621969 APP 1 GO:0051963 regulation of synapse assembly 4/1165 101/18722 0.881137731888624 0.91776323790886 DLG5/APP/TLR2/ABI3 4 GO:0051303 establishment of chromosome localization 3/1165 80/18722 0.882041940726225 0.918534585027143 CENPF/RAB11A/CCNB1 3 GO:0010559 regulation of glycoprotein biosynthetic process 2/1165 58/18722 0.883620476559282 0.920007741592886 PAWR/ITM2C 2 GO:0006672 ceramide metabolic process 4/1165 102/18722 0.885740153968583 0.922043672890514 PLPP3/ITGB8/DEGS1/ORMDL1 4 GO:0009303 rRNA transcription 1/1165 34/18722 0.887676730155893 0.922349034869498 NCL 1 GO:0034724 DNA replication-independent nucleosome organization 1/1165 34/18722 0.887676730155893 0.922349034869498 NASP 1 GO:0043276 anoikis 1/1165 34/18722 0.887676730155893 0.922349034869498 ITGB1 1 GO:0048741 skeletal muscle fiber development 1/1165 34/18722 0.887676730155893 0.922349034869498 GPX1 1 GO:0048854 brain morphogenesis 1/1165 34/18722 0.887676730155893 0.922349034869498 SLC6A4 1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 1/1165 34/18722 0.887676730155893 0.922349034869498 TGM2 1 GO:0070050 neuron cellular homeostasis 1/1165 34/18722 0.887676730155893 0.922349034869498 ATP2B1 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/1165 34/18722 0.887676730155893 0.922349034869498 SOCS3 1 GO:2000352 negative regulation of endothelial cell apoptotic process 1/1165 34/18722 0.887676730155893 0.922349034869498 GATA3 1 GO:2000780 negative regulation of double-strand break repair 1/1165 34/18722 0.887676730155893 0.922349034869498 MAGEF1 1 GO:0007281 germ cell development 13/1165 278/18722 0.888883548113538 0.923432048040216 LGR5/JAM3/ASPM/SLIRP/PTN/SMARCA2/ETV5/PITHD1/CIB1/DLD/CDYL/DEFB1/CCNB1 13 GO:0048278 vesicle docking 2/1165 59/18722 0.889385516429065 0.923440788700766 STXBP2/CLN3 2 GO:2000351 regulation of endothelial cell apoptotic process 2/1165 59/18722 0.889385516429065 0.923440788700766 GATA3/PDCD4 2 GO:2001258 negative regulation of cation channel activity 2/1165 59/18722 0.889385516429065 0.923440788700766 ANK3/GSTO1 2 GO:0030148 sphingolipid biosynthetic process 4/1165 103/18722 0.89018637562857 0.924101373479409 HACD3/PLPP3/DEGS1/ORMDL1 4 GO:0043414 macromolecule methylation 15/1165 316/18722 0.89111245649452 0.924891682378651 GATA3/PARP1/HELLS/BRD4/DNMT1/FOS/DNMT3A/SPI1/SMYD2/RTF1/RNMT/SNRPD3/ZC3H13/MBD2/PRMT1 15 GO:0008543 fibroblast growth factor receptor signaling pathway 3/1165 82/18722 0.891986345780871 0.925456443413684 GATA3/GPC1/SULF2 3 GO:0050000 chromosome localization 3/1165 82/18722 0.891986345780871 0.925456443413684 CENPF/RAB11A/CCNB1 3 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 4/1165 104/18722 0.894480419447909 0.926195625879281 GNA11/TGM2/FPR1/FPR3 4 GO:0022600 digestive system process 4/1165 104/18722 0.894480419447909 0.926195625879281 TYMP/LIMA1/KCNN4/SNX10 4 GO:0000731 DNA synthesis involved in DNA repair 1/1165 35/18722 0.894678903174321 0.926195625879281 VCP 1 GO:0006298 mismatch repair 1/1165 35/18722 0.894678903174321 0.926195625879281 RPA3 1 GO:0007020 microtubule nucleation 1/1165 35/18722 0.894678903174321 0.926195625879281 AKAP9 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/1165 35/18722 0.894678903174321 0.926195625879281 CCNB1 1 GO:0019068 virion assembly 1/1165 35/18722 0.894678903174321 0.926195625879281 APOE 1 GO:0032350 regulation of hormone metabolic process 1/1165 35/18722 0.894678903174321 0.926195625879281 GATA3 1 GO:0044273 sulfur compound catabolic process 1/1165 35/18722 0.894678903174321 0.926195625879281 CDO1 1 GO:0046471 phosphatidylglycerol metabolic process 1/1165 35/18722 0.894678903174321 0.926195625879281 STOML2 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/1165 35/18722 0.894678903174321 0.926195625879281 CHPF 1 GO:1905898 positive regulation of response to endoplasmic reticulum stress 1/1165 35/18722 0.894678903174321 0.926195625879281 PMAIP1 1 GO:0018210 peptidyl-threonine modification 5/1165 125/18722 0.89534842168553 0.926717811344437 BMP7/APP/GALNT11/PRKDC/TGFB1 5 GO:0140013 meiotic nuclear division 8/1165 185/18722 0.895643756360219 0.926852581941355 ASPM/CCNE1/UBB/RAD50/CKS2/CALR/RAD21/TOP2A 8 GO:1902115 regulation of organelle assembly 8/1165 186/18722 0.898821434834676 0.929969532484246 YAP1/NPM1/LCP1/RHOA/ATMIN/MSN/HCK/ABI3 8 GO:0043966 histone H3 acetylation 2/1165 61/18722 0.900128198813571 0.930247832354746 GATA3/SPI1 2 GO:1905515 non-motile cilium assembly 2/1165 61/18722 0.900128198813571 0.930247832354746 ATMIN/PCM1 2 GO:0055088 lipid homeostasis 7/1165 167/18722 0.901151609435555 0.930247832354746 LRP5/CD24/LIMA1/APOE/ORMDL1/MYLIP/TREM2 7 GO:0006405 RNA export from nucleus 3/1165 84/18722 0.901172262052677 0.930247832354746 NPM1/RAN/NUP214 3 GO:0007031 peroxisome organization 1/1165 36/18722 0.901244915792821 0.930247832354746 FIS1 1 GO:0014046 dopamine secretion 1/1165 36/18722 0.901244915792821 0.930247832354746 SYT7 1 GO:0014059 regulation of dopamine secretion 1/1165 36/18722 0.901244915792821 0.930247832354746 SYT7 1 GO:0042755 eating behavior 1/1165 36/18722 0.901244915792821 0.930247832354746 GDF15 1 GO:0043949 regulation of cAMP-mediated signaling 1/1165 36/18722 0.901244915792821 0.930247832354746 GNAI1 1 GO:0046466 membrane lipid catabolic process 1/1165 36/18722 0.901244915792821 0.930247832354746 FUCA1 1 GO:0051354 negative regulation of oxidoreductase activity 1/1165 36/18722 0.901244915792821 0.930247832354746 ATP2B4 1 GO:0097009 energy homeostasis 1/1165 36/18722 0.901244915792821 0.930247832354746 UBB 1 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 1/1165 36/18722 0.901244915792821 0.930247832354746 NMT1 1 GO:0006906 vesicle fusion 4/1165 106/18722 0.902627933957229 0.931504062015431 SYT7/VAV3/SAMD9/CLN3 4 GO:0006911 phagocytosis, engulfment 5/1165 127/18722 0.902822903152465 0.931533999153454 AIF1/RHOBTB1/TREM2/RHOG/CD300A 5 GO:0019933 cAMP-mediated signaling 2/1165 62/18722 0.90512703948406 0.933684132844066 GNAI1/DEFB1 2 GO:0010507 negative regulation of autophagy 3/1165 85/18722 0.905495733180428 0.933684132844066 MET/TREM2/TSPO 3 GO:0097194 execution phase of apoptosis 3/1165 85/18722 0.905495733180428 0.933684132844066 BLCAP/PLSCR1/TOP2A 3 GO:0000154 rRNA modification 1/1165 37/18722 0.907401914246282 0.933684132844066 NHP2 1 GO:0003016 respiratory system process 1/1165 37/18722 0.907401914246282 0.933684132844066 ADH5 1 GO:0006904 vesicle docking involved in exocytosis 1/1165 37/18722 0.907401914246282 0.933684132844066 STXBP2 1 GO:0007340 acrosome reaction 1/1165 37/18722 0.907401914246282 0.933684132844066 SPESP1 1 GO:0014904 myotube cell development 1/1165 37/18722 0.907401914246282 0.933684132844066 GPX1 1 GO:0030513 positive regulation of BMP signaling pathway 1/1165 37/18722 0.907401914246282 0.933684132844066 GPC3 1 GO:0033363 secretory granule organization 1/1165 37/18722 0.907401914246282 0.933684132844066 SRGN 1 GO:0042178 xenobiotic catabolic process 1/1165 37/18722 0.907401914246282 0.933684132844066 GSTO1 1 GO:0051567 histone H3-K9 methylation 1/1165 37/18722 0.907401914246282 0.933684132844066 DNMT1 1 GO:0051954 positive regulation of amine transport 1/1165 37/18722 0.907401914246282 0.933684132844066 ITGB1 1 GO:0097484 dendrite extension 1/1165 37/18722 0.907401914246282 0.933684132844066 CXCR4 1 GO:1902745 positive regulation of lamellipodium organization 1/1165 37/18722 0.907401914246282 0.933684132844066 WASF2 1 GO:0006493 protein O-linked glycosylation 3/1165 86/18722 0.909647324312709 0.935730872735795 GALNT11/ST3GAL4/C1GALT1 3 GO:0001947 heart looping 2/1165 63/18722 0.909891163975052 0.935730872735795 FOLR1/TBX3 2 GO:0045143 homologous chromosome segregation 2/1165 63/18722 0.909891163975052 0.935730872735795 CCNE1/RAD21 2 GO:0007098 centrosome cycle 5/1165 130/18722 0.91316220181413 0.938077100375689 PARD6B/NPM1/ATF5/RANBP1/PCM1 5 GO:0030534 adult behavior 5/1165 130/18722 0.91316220181413 0.938077100375689 APP/ATP6V1B1/EPS8/PARK7/HDAC2 5 GO:0002385 mucosal immune response 1/1165 38/18722 0.913175356574517 0.938077100375689 DEFB1 1 GO:0030279 negative regulation of ossification 1/1165 38/18722 0.913175356574517 0.938077100375689 SRGN 1 GO:0048246 macrophage chemotaxis 1/1165 38/18722 0.913175356574517 0.938077100375689 LGALS3 1 GO:0072538 T-helper 17 type immune response 1/1165 38/18722 0.913175356574517 0.938077100375689 PHB 1 GO:0018022 peptidyl-lysine methylation 5/1165 131/18722 0.916387331163816 0.941204408018755 GATA3/BRD4/DNMT1/SMYD2/RTF1 5 GO:0030317 flagellated sperm motility 4/1165 110/18722 0.917270394025681 0.941594499207415 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0090174 organelle membrane fusion 4/1165 110/18722 0.917270394025681 0.941594499207415 SYT7/VAV3/SAMD9/CLN3 4 GO:0097722 sperm motility 4/1165 110/18722 0.917270394025681 0.941594499207415 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0021587 cerebellum morphogenesis 1/1165 39/18722 0.918589117524565 0.942083957536865 HSPA5 1 GO:0032506 cytokinetic process 1/1165 39/18722 0.918589117524565 0.942083957536865 RHOA 1 GO:0043267 negative regulation of potassium ion transport 1/1165 39/18722 0.918589117524565 0.942083957536865 ANK3 1 GO:0045923 positive regulation of fatty acid metabolic process 1/1165 39/18722 0.918589117524565 0.942083957536865 CD74 1 GO:0046513 ceramide biosynthetic process 2/1165 65/18722 0.918754246135186 0.942083957536865 DEGS1/ORMDL1 2 GO:0072577 endothelial cell apoptotic process 2/1165 65/18722 0.918754246135186 0.942083957536865 GATA3/PDCD4 2 GO:0000910 cytokinesis 7/1165 173/18722 0.919014435213512 0.942178634676428 MYH10/ANK3/RASA1/RHOA/STMN1/RAB11A/SON 7 GO:0045017 glycerolipid biosynthetic process 11/1165 252/18722 0.919333939286177 0.942334076189429 PGAP2/SH3YL1/PISD/GPAA1/SLC44A2/PLSCR1/PIK3C2A/TMEM150A/CLN3/SOCS3/GK 11 GO:0120254 olefinic compound metabolic process 6/1165 153/18722 0.920099338839369 0.942946428501986 HSD17B1/MGLL/AKR1B1/GPX1/GSTP1/GPX4 6 GO:0006805 xenobiotic metabolic process 4/1165 111/18722 0.92060906910463 0.943296587237 GSTA4/GSTP1/GSTO1/S100A12 4 GO:0031297 replication fork processing 1/1165 40/18722 0.923665586939749 0.945910406767526 NUCKS1 1 GO:0032094 response to food 1/1165 40/18722 0.923665586939749 0.945910406767526 NENF 1 GO:0055081 anion homeostasis 1/1165 40/18722 0.923665586939749 0.945910406767526 ATP6V1B1 1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 3/1165 90/18722 0.924647245421156 0.946742974926842 VCP/DAB2/MDM2 3 GO:0061371 determination of heart left/right asymmetry 2/1165 67/18722 0.926792289945077 0.948766208911493 FOLR1/TBX3 2 GO:0000209 protein polyubiquitination 10/1165 236/18722 0.927102296501214 0.948880881705792 KLHL42/SKP2/UBE2L6/UBE4B/UBE2H/ANAPC11/MDM2/TRIM22/WWP1/PPIA 10 GO:0051952 regulation of amine transport 3/1165 91/18722 0.928022694249139 0.948880881705792 SYT7/ITGB1/ARL6IP5 3 GO:0009581 detection of external stimulus 5/1165 135/18722 0.928255283460505 0.948880881705792 CXCR4/NR2F6/GNA11/OPN3/NMT1 5 GO:0002251 organ or tissue specific immune response 1/1165 41/18722 0.928425762039588 0.948880881705792 DEFB1 1 GO:0006418 tRNA aminoacylation for protein translation 1/1165 41/18722 0.928425762039588 0.948880881705792 IARS2 1 GO:0007099 centriole replication 1/1165 41/18722 0.928425762039588 0.948880881705792 NPM1 1 GO:0048286 lung alveolus development 1/1165 41/18722 0.928425762039588 0.948880881705792 MAN1A2 1 GO:0050892 intestinal absorption 1/1165 41/18722 0.928425762039588 0.948880881705792 LIMA1 1 GO:1902116 negative regulation of organelle assembly 1/1165 41/18722 0.928425762039588 0.948880881705792 YAP1 1 GO:0035249 synaptic transmission, glutamatergic 3/1165 92/18722 0.931258741044059 0.951603006277135 EGFR/GLUL/CLN3 3 GO:0019432 triglyceride biosynthetic process 1/1165 42/18722 0.932889333969564 0.952402297484751 GK 1 GO:0021575 hindbrain morphogenesis 1/1165 42/18722 0.932889333969564 0.952402297484751 HSPA5 1 GO:0032467 positive regulation of cytokinesis 1/1165 42/18722 0.932889333969564 0.952402297484751 RHOA 1 GO:0055090 acylglycerol homeostasis 1/1165 42/18722 0.932889333969564 0.952402297484751 APOE 1 GO:0070328 triglyceride homeostasis 1/1165 42/18722 0.932889333969564 0.952402297484751 APOE 1 GO:0007586 digestion 5/1165 137/18722 0.933607455506346 0.95278884504675 TYMP/LIMA1/KCNN4/SNX10/PIR 5 GO:0060078 regulation of postsynaptic membrane potential 5/1165 137/18722 0.933607455506346 0.95278884504675 ADRB1/GABRE/APP/PRKCZ/SLC29A1 5 GO:0019217 regulation of fatty acid metabolic process 3/1165 93/18722 0.934360374262917 0.953210610821111 APOC1/CD74/ACADVL 3 GO:0045132 meiotic chromosome segregation 3/1165 93/18722 0.934360374262917 0.953210610821111 CCNE1/RAD21/TOP2A 3 GO:0018107 peptidyl-threonine phosphorylation 4/1165 116/18722 0.935554295312888 0.954221390112217 BMP7/APP/PRKDC/TGFB1 4 GO:0046488 phosphatidylinositol metabolic process 6/1165 159/18722 0.935691168925288 0.954221390112217 PGAP2/SH3YL1/GPAA1/PIK3C2A/TMEM150A/SOCS3 6 GO:0009582 detection of abiotic stimulus 5/1165 138/18722 0.936147273738397 0.954513105811739 CXCR4/NR2F6/GNA11/OPN3/NMT1 5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1/1165 43/18722 0.93707476897628 0.954765053233592 FXYD5 1 GO:0032365 intracellular lipid transport 1/1165 43/18722 0.93707476897628 0.954765053233592 SYT7 1 GO:0045494 photoreceptor cell maintenance 1/1165 43/18722 0.93707476897628 0.954765053233592 SLC2A1 1 GO:0046717 acid secretion 1/1165 43/18722 0.93707476897628 0.954765053233592 SNX10 1 GO:1903035 negative regulation of response to wounding 3/1165 94/18722 0.937332456164844 0.954836328735978 GJA1/APOE/CD9 3 GO:0065004 protein-DNA complex assembly 8/1165 201/18722 0.937484947027253 0.954836328735978 NASP/HELLS/NPM1/TAF11/PSMC6/CENPF/SET/GMNN 8 GO:0051321 meiotic cell cycle 11/1165 261/18722 0.93783391214596 0.955018459520188 ASPM/DUSP1/CCNE1/PRKACB/UBB/RAD50/CKS2/CALR/RAD21/TOP2A/SMC3 11 GO:0006479 protein methylation 7/1165 181/18722 0.938438367308643 0.955287369550855 GATA3/BRD4/DNMT1/SMYD2/RTF1/SNRPD3/PRMT1 7 GO:0008213 protein alkylation 7/1165 181/18722 0.938438367308643 0.955287369550855 GATA3/BRD4/DNMT1/SMYD2/RTF1/SNRPD3/PRMT1 7 GO:1903046 meiotic cell cycle process 8/1165 202/18722 0.939527850996825 0.95622299685316 ASPM/CCNE1/UBB/RAD50/CKS2/CALR/RAD21/TOP2A 8 GO:0045666 positive regulation of neuron differentiation 3/1165 95/18722 0.940179722058935 0.956712976779696 BMP7/RHOA/ETV5 3 GO:0002792 negative regulation of peptide secretion 1/1165 44/18722 0.940999384541494 0.957026552895707 CD74 1 GO:0043039 tRNA aminoacylation 1/1165 44/18722 0.940999384541494 0.957026552895707 IARS2 1 GO:0044058 regulation of digestive system process 1/1165 44/18722 0.940999384541494 0.957026552895707 TYMP 1 GO:0010824 regulation of centrosome duplication 1/1165 45/18722 0.944679420787835 0.959552223829555 NPM1 1 GO:0043038 amino acid activation 1/1165 45/18722 0.944679420787835 0.959552223829555 IARS2 1 GO:0044088 regulation of vacuole organization 1/1165 45/18722 0.944679420787835 0.959552223829555 GRN 1 GO:0045910 negative regulation of DNA recombination 1/1165 45/18722 0.944679420787835 0.959552223829555 MAGEF1 1 GO:0048546 digestive tract morphogenesis 1/1165 45/18722 0.944679420787835 0.959552223829555 GLI3 1 GO:0048599 oocyte development 1/1165 45/18722 0.944679420787835 0.959552223829555 CCNB1 1 GO:0098534 centriole assembly 1/1165 45/18722 0.944679420787835 0.959552223829555 NPM1 1 GO:0051865 protein autoubiquitination 2/1165 73/18722 0.94663108862053 0.961360647806592 MDM2/RNF213 2 GO:0031023 microtubule organizing center organization 5/1165 143/18722 0.947583842411302 0.962154143895557 PARD6B/NPM1/ATF5/RANBP1/PCM1 5 GO:0010830 regulation of myotube differentiation 1/1165 46/18722 0.948130107449621 0.962186637699281 BHLHE41 1 GO:0043462 regulation of ATPase activity 1/1165 46/18722 0.948130107449621 0.962186637699281 CNN3 1 GO:0046839 phospholipid dephosphorylation 1/1165 46/18722 0.948130107449621 0.962186637699281 PLPP3 1 GO:0016073 snRNA metabolic process 1/1165 47/18722 0.951365726683996 0.964946842045043 NHP2 1 GO:0048512 circadian behavior 1/1165 47/18722 0.951365726683996 0.964946842045043 ADRB1 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1165 47/18722 0.951365726683996 0.964946842045043 VEGFA 1 GO:0036465 synaptic vesicle recycling 2/1165 75/18722 0.95202029407912 0.965436298223325 SYT7/ACTB 2 GO:0006910 phagocytosis, recognition 3/1165 100/18722 0.952700646221964 0.965777266975598 COLEC12/FCN1/TREM2 3 GO:0060079 excitatory postsynaptic potential 3/1165 100/18722 0.952700646221964 0.965777266975598 APP/PRKCZ/SLC29A1 3 GO:0007368 determination of left/right symmetry 4/1165 124/18722 0.954227632312947 0.966975696539139 FOLR1/GALNT11/TBX3/AP1B1 4 GO:0044458 motile cilium assembly 1/1165 48/18722 0.95439967198055 0.966975696539139 ATMIN 1 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 1/1165 48/18722 0.95439967198055 0.966975696539139 NUCKS1 1 GO:0060294 cilium movement involved in cell motility 4/1165 125/18722 0.956174052498977 0.968598620587756 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0007622 rhythmic behavior 1/1165 49/18722 0.957244503411559 0.969158260759214 ADRB1 1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1/1165 49/18722 0.957244503411559 0.969158260759214 SKP2 1 GO:1990573 potassium ion import across plasma membrane 1/1165 49/18722 0.957244503411559 0.969158260759214 DLG1 1 GO:1905037 autophagosome organization 3/1165 103/18722 0.958990852282845 0.970283820081536 VMP1/CLN3/GABARAPL1 3 GO:0007140 male meiotic nuclear division 1/1165 50/18722 0.959911999449985 0.970283820081536 UBB 1 GO:0008089 anterograde axonal transport 1/1165 50/18722 0.959911999449985 0.970283820081536 SOD1 1 GO:0042572 retinol metabolic process 1/1165 50/18722 0.959911999449985 0.970283820081536 AKR1B1 1 GO:0043628 ncRNA 3'-end processing 1/1165 50/18722 0.959911999449985 0.970283820081536 RPS21 1 GO:0046460 neutral lipid biosynthetic process 1/1165 50/18722 0.959911999449985 0.970283820081536 GK 1 GO:0046463 acylglycerol biosynthetic process 1/1165 50/18722 0.959911999449985 0.970283820081536 GK 1 GO:0090102 cochlea development 1/1165 50/18722 0.959911999449985 0.970283820081536 GATA3 1 GO:0099054 presynapse assembly 1/1165 50/18722 0.959911999449985 0.970283820081536 APP 1 GO:0050982 detection of mechanical stimulus 1/1165 51/18722 0.962413205568278 0.972636896444859 CXCR4 1 GO:0099565 chemical synaptic transmission, postsynaptic 3/1165 106/18722 0.964489591274592 0.974559869635335 APP/PRKCZ/SLC29A1 3 GO:0098813 nuclear chromosome segregation 11/1165 281/18722 0.966305404679168 0.976218905051146 DUSP1/CCNE1/RAN/ANAPC11/CENPF/NAA10/RAD21/RAB11A/TOP2A/SMC3/CCNB1 11 GO:0099172 presynapse organization 1/1165 53/18722 0.966957535576364 0.976701933991386 APP 1 GO:0071824 protein-DNA complex subunit organization 9/1165 241/18722 0.967507773074293 0.977081887417418 NASP/RPL23/HELLS/NPM1/TAF11/PSMC6/CENPF/SET/GMNN 9 GO:0006323 DNA packaging 7/1165 199/18722 0.967843779638194 0.977245392176503 NASP/HELLS/NPM1/NAA10/SET/TOP2A/CCNB1 7 GO:0001510 RNA methylation 2/1165 83/18722 0.968809633588526 0.977904773542389 RNMT/ZC3H13 2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1165 54/18722 0.969019481639545 0.977904773542389 VEGFA 1 GO:0043647 inositol phosphate metabolic process 1/1165 54/18722 0.969019481639545 0.977904773542389 NUDT4 1 GO:0009855 determination of bilateral symmetry 4/1165 133/18722 0.969201024407488 0.977912160704517 FOLR1/GALNT11/TBX3/AP1B1 4 GO:0007416 synapse assembly 6/1165 179/18722 0.969963267275552 0.978329527262835 CDH1/DLG5/APP/OBSL1/TLR2/ABI3 6 GO:0007626 locomotory behavior 6/1165 179/18722 0.969963267275552 0.978329527262835 DPP4/APP/SOD1/APOE/EPS8/PARK7 6 GO:0009953 dorsal/ventral pattern formation 2/1165 84/18722 0.970459325577206 0.978567200682584 GLI3/PRKACB 2 GO:0009799 specification of symmetry 4/1165 134/18722 0.97054758706573 0.978567200682584 FOLR1/GALNT11/TBX3/AP1B1 4 GO:0006414 translational elongation 1/1165 55/18722 0.970952859820922 0.978624241726492 RPLP2 1 GO:0008333 endosome to lysosome transport 1/1165 55/18722 0.970952859820922 0.978624241726492 VCP 1 GO:0006687 glycosphingolipid metabolic process 1/1165 56/18722 0.972765680215662 0.980099401014273 ITGB8 1 GO:0050433 regulation of catecholamine secretion 1/1165 56/18722 0.972765680215662 0.980099401014273 SYT7 1 GO:0007029 endoplasmic reticulum organization 2/1165 87/18722 0.974918763430925 0.982092429852438 LMAN1/CCDC47 2 GO:0001539 cilium or flagellum-dependent cell motility 4/1165 138/18722 0.9754020554936 0.982226720036882 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0060285 cilium-dependent cell motility 4/1165 138/18722 0.9754020554936 0.982226720036882 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0050432 catecholamine secretion 1/1165 58/18722 0.976059225811537 0.982712185556979 SYT7 1 GO:0090630 activation of GTPase activity 3/1165 115/18722 0.977106137256377 0.983589804236019 SYDE2/EIF5/RHOG 3 GO:0006406 mRNA export from nucleus 1/1165 59/18722 0.977553600111235 0.983687407211251 NUP214 1 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 1/1165 59/18722 0.977553600111235 0.983687407211251 NUP214 1 GO:0051965 positive regulation of synapse assembly 1/1165 60/18722 0.978954771191469 0.984920797759045 DLG5 1 GO:0009451 RNA modification 5/1165 167/18722 0.980642204171413 0.986441701077803 APOBEC3A/RBM47/NHP2/RNMT/ZC3H13 5 GO:0032465 regulation of cytokinesis 2/1165 92/18722 0.980943544885256 0.986568019609558 RHOA/RAB11A 2 GO:0048488 synaptic vesicle endocytosis 1/1165 62/18722 0.981500375396352 0.986774423625242 ACTB 1 GO:0140238 presynaptic endocytosis 1/1165 62/18722 0.981500375396352 0.986774423625242 ACTB 1 GO:0007018 microtubule-based movement 15/1165 382/18722 0.98186909497576 0.986884278706838 APP/PRKCZ/SOD1/SLIRP/UBB/ARMCX3/ATP2B4/HSPB11/LRPPRC/DST/PCM1/DEFB1/CLN3/CATSPER1/HSPA8 15 GO:0007269 neurotransmitter secretion 4/1165 145/18722 0.982137106869125 0.986884278706838 SYT7/STXBP2/PNKD/NR4A1 4 GO:0099643 signal release from synapse 4/1165 145/18722 0.982137106869125 0.986884278706838 SYT7/STXBP2/PNKD/NR4A1 4 GO:0001756 somitogenesis 1/1165 63/18722 0.982655362677341 0.987228306910312 PRKDC 1 GO:0046888 negative regulation of hormone secretion 1/1165 64/18722 0.983738298658953 0.988139418463261 GJA1 1 GO:0031497 chromatin assembly 4/1165 151/18722 0.986482346886643 0.990718449288733 NASP/HELLS/NPM1/SET 4 GO:0000045 autophagosome assembly 2/1165 99/18722 0.987076688974727 0.991138006299668 VMP1/GABARAPL1 2 GO:0006333 chromatin assembly or disassembly 5/1165 177/18722 0.987481615943471 0.991367252779593 NASP/HELLS/NPM1/TLK1/SET 5 GO:0051588 regulation of neurotransmitter transport 2/1165 100/18722 0.987778240867641 0.991487708510384 ITGB1/PNKD 2 GO:0006334 nucleosome assembly 3/1165 129/18722 0.988646938668665 0.992182239718795 NASP/NPM1/SET 3 GO:0051298 centrosome duplication 1/1165 73/18722 0.99089870851975 0.994264292263382 NPM1 1 GO:0001578 microtubule bundle formation 2/1165 113/18722 0.994124045733235 0.997322300035862 CAPN6/CLIP1 2 GO:0061053 somite development 1/1165 83/18722 0.995225964324775 0.998249345560214 PRKDC 1 GO:0003341 cilium movement 4/1165 175/18722 0.995725224568091 0.998571678667267 SLIRP/ATP2B4/DEFB1/CATSPER1 4 GO:0046928 regulation of neurotransmitter secretion 1/1165 86/18722 0.996066400243202 0.998735388453929 PNKD 1 GO:0035278 miRNA mediated inhibition of translation 1/1165 90/18722 0.996961626978325 0.999276002183811 ZFP36 1 GO:0040033 negative regulation of translation, ncRNA-mediated 1/1165 90/18722 0.996961626978325 0.999276002183811 ZFP36 1 GO:0045974 regulation of translation, ncRNA-mediated 1/1165 91/18722 0.997151606828596 0.99928797877681 ZFP36 1 GO:0007601 visual perception 5/1165 215/18722 0.997815357161153 0.99945325537627 EFEMP1/TACSTD2/TIMP3/EPAS1/MYO7A 5 GO:0060271 cilium assembly 10/1165 337/18722 0.997922881443421 0.99945325537627 LAMA5/GALNT11/YAP1/SNX10/DYNLL2/FNBP1L/FLNA/ATMIN/ARF4/PCM1 10 GO:0006997 nucleus organization 2/1165 133/18722 0.998134676116956 0.99945325537627 SERBP1/SF1 2 GO:0050953 sensory perception of light stimulus 5/1165 219/18722 0.99819490617307 0.99945325537627 EFEMP1/TACSTD2/TIMP3/EPAS1/MYO7A 5 GO:0034728 nucleosome organization 3/1165 167/18722 0.998450894183244 0.99945325537627 NASP/NPM1/SET 3 GO:0044782 cilium organization 11/1165 368/18722 0.998490812792087 0.99945325537627 LAMA5/GALNT11/YAP1/SNX10/DYNLL2/FNBP1L/FLNA/ATMIN/HSPB11/ARF4/PCM1 11 GO:0099003 vesicle-mediated transport in synapse 4/1165 200/18722 0.998776231092411 0.99945325537627 NSG1/SYT7/ACTB/RAB11A 4 GO:0016079 synaptic vesicle exocytosis 1/1165 105/18722 0.998846917353272 0.99945325537627 SYT7 1 GO:0007218 neuropeptide signaling pathway 1/1165 106/18722 0.998919074053247 0.99945325537627 SORL1 1 GO:0008033 tRNA processing 1/1165 127/18722 0.999721976472026 0.999889610173206 DDX1 1 GO:0006399 tRNA metabolic process 2/1165 179/18722 0.999875609093765 0.999889610173206 IARS2/DDX1 2 GO:0099504 synaptic vesicle cycle 2/1165 181/18722 0.999889610173206 0.999889610173206 SYT7/ACTB 2