ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	93/2244	182/18367	1.25005930943643e-37	1.37131506245177e-34	RPS4Y1/RPS29/RPS21/RPS27/RPS5/RPS18/RPL18/RPLP0/RPS3/RPS12/RPSA/RPS23/RPS16/RPS27A/RPL5/RPS19/RPS9/RPL27A/RPL10A/RPS7/RPL7A/MRPL12/RPS17/RPS8/MRPL4/RPLP2/RPS14/RPL3/MRPL15/ISG15/MRPL19/RPS28/RPL23A/RPL36/MRPL27/RPS25/RPL37A/RPL8/MRPL1/MRPS33/MRPL37/RPL35/RPL37/RPL21/MRPS21/MRPL57/RPL14/MRPS15/RPL31/RPL32/MRPL46/MRPS2/MRPL11/MRPS34/RPS15A/MRPS6/MRPL14/MRPL2/MRPL22/RPL15/RPL23/MRPS7/MRPL17/RPL22/MRPL21/MRPS18B/RPLP1/MRPL9/RPL28/MRPS12/MRPL43/MRPS18A/RPL26L1/MRPL32/MRPL51/MRPS25/RPS4X/MRPL3/MRPL42/MRPS18C/MRPS16/MRPL20/RPL7L1/MRPL13/RPS15/RPL24/RPS10/MRPL34/RPS6/MRPL55/MRPL52/RPL12/MRPL36	93
GO:0045296	cadherin binding	105/2244	332/18367	4.17364111409292e-21	2.28924215107997e-18	CDH1/EGFR/ITGA6/CALD1/CTNNAL1/KRT18/PDLIM1/FMNL2/TJP1/EPN2/ANK3/LIMA1/TRIM29/COBLL1/PRDX1/EPS8L2/PPP1R13L/DOCK9/ATIC/BSG/HSP90AB1/DIAPH3/FNBP1L/CNN3/PHLDB2/SPTBN1/FXYD5/ITGB1/PPFIBP1/MICALL1/PSMB6/SH3GLB2/PKP3/CTTN/S100P/PAICS/BAIAP2/CTNND1/EFHD2/MB21D2/PARVA/RAN/BZW2/RPL7A/FASN/CD2AP/CCNB2/RANBP1/FLNA/IDH1/HSPA5/PRDX6/ANXA2/DLG1/RPL23A/CD46/STAT1/CAPG/RPL14/MPP7/ARHGAP18/PKP2/FLNB/NOP56/WASF2/YWHAE/UBAP2/SWAP70/RDX/PTPN1/JUP/PDXDC1/RPL15/RUVBL1/ERC1/CTNNB1/VASP/SND1/HDLBP/SLK/EZR/LRRFIP1/AHSA1/PARK7/HSPA8/PUF60/GLOD4/EIF5/TXNDC9/SLC3A2/PTPN11/RPL24/SERBP1/IQGAP1/OLA1/CLIC1/CCT8/ARGLU1/NUDC/EPS8L1/CAPZA1/CNN2/PAK2/HSPA1A/KTN1	105
GO:0009055	electron transfer activity	49/2244	126/18367	2.06035732565784e-14	6.14321459053428e-12	GLDC/CYBA/CYBB/CYB5A/AKR1B1/DEGS1/NCF1/ADH5/ASPH/NCF2/DHRS3/NDUFA10/COX6A1/NDUFA6/ETFA/NDUFV1/NDUFB9/UQCR10/NDUFB7/NDUFC2/NDUFS8/NDUFB2/ALDH2/COX7A2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/ETFB/NDUFA4/NDUFS5/CYC1/FDX1/NDUFB6/NDUFV2/NDUFA13/AKR7A2/NDUFB4/CIAPIN1/NDUFS4/NDUFS3/NDUFA1/COX5A/NDUFA3/NDUFC1/UQCRH/UQCRC1/NDUFB3/UQCRFS1	49
GO:0051082	unfolded protein binding	48/2244	122/18367	2.24000532015835e-14	6.14321459053428e-12	SERPINH1/LMAN1/HSP90B1/HSPD1/HSP90AB1/HSPE1/NPM1/HSP90AA1/DNAJB4/TUBB4B/CCT2/PPIB/CALR/HSPA5/TRAP1/PPIA/PFDN5/ST13/ERLEC1/CCT4/NUDCD2/SIL1/HSPA2/PFDN1/PFDN4/AFG3L2/HSPA14/CCT3/TCP1/NAP1L4/RUVBL2/HSPA8/PFDN6/TAPBP/HSPA9/GRPEL1/PFDN2/SRSF10/CCT6A/TTC1/CCT7/MKKS/DNAJB6/CCT8/CCT5/NUDC/HSPA1A/TOMM20	48
GO:0008137	NADH dehydrogenase (ubiquinone) activity	24/2244	42/18367	4.21858911805313e-12	9.25558452500856e-10	NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	24
GO:0050136	NADH dehydrogenase (quinone) activity	24/2244	43/18367	8.44159971374766e-12	1.3601756563586e-09	NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	24
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	32/2244	72/18367	9.91575523664863e-12	1.3601756563586e-09	CYB5A/NDUFA10/COX6A1/NDUFA6/NDUFV1/NDUFB9/UQCR10/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/CYC1/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/COX5A/NDUFA3/NDUFC1/UQCRH/UQCRC1/NDUFB3/UQCRFS1	32
GO:0044183	protein folding chaperone	23/2244	40/18367	9.91923906186766e-12	1.3601756563586e-09	CD74/HSP90AB1/CCT2/CALR/HSPA5/DFFA/CCT4/HSPA2/PFDN1/CCDC47/HSPA14/CCT3/TCP1/HSPA8/HSPB1/HSPA9/PFDN2/CCT6A/CCT7/DNAJB6/CCT8/CCT5/HSPA1A	23
GO:0003954	NADH dehydrogenase activity	24/2244	45/18367	3.11143152930958e-11	3.41324038765261e-09	NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	24
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	24/2244	45/18367	3.11143152930958e-11	3.41324038765261e-09	NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	24
GO:0019843	rRNA binding	30/2244	68/18367	5.50795917506048e-11	5.4929374682194e-09	RPS4Y1/RPS5/RPS18/RPLP0/RPS3/NPM1/RPL5/RPS9/BRIX1/RPS14/RPL23A/RPL8/CIRBP/RPL37/MRPS27/MRPL11/MRPS6/ERAL1/RPL23/MRPS7/RPF2/EMG1/MRPS18A/SBDS/RPS4X/IMP3/MRPS18C/MRPL20/MDM2/RPL12	30
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	25/2244	57/18367	2.54871844305841e-09	2.32995344336256e-07	DCXR/NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	25
GO:0023026	MHC class II protein complex binding	16/2244	27/18367	8.09324996412266e-09	6.82945785434043e-07	B2M/CD74/HLA-DRA/HSP90AB1/HSP90AA1/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/YWHAE/HLA-DMB/CD81/HSPA8/HLA-DQB1/CD4/HLA-DQA2	16
GO:0023023	MHC protein complex binding	18/2244	36/18367	3.51548920870037e-08	2.75463690138879e-06	B2M/CD74/HLA-DRA/HSP90AB1/HSP90AA1/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/LILRB2/YWHAE/HLA-DMB/CD81/HSPA8/HLA-DQB1/LILRB1/CD4/HLA-DQA2	18
GO:0005178	integrin binding	42/2244	144/18367	3.98334817468783e-08	2.90680620525873e-06	FBN1/ITGB4/LAMB1/EGFR/LAMA5/FBLN1/PLPP3/FERMT1/FERMT2/ITGB5/LCP1/ITGB8/ITGAV/ITGB2/JAM3/PTN/P4HB/MMP14/ITGB1/DST/EMP2/PTK2/S1PR2/CALR/ISG15/LYN/JAML/PPIA/IGF2/CD151/HMGB1/CD81/TSPAN4/FERMT3/ITGA4/ICAM3/SYK/TGFBI/TIMP2/IL1B/ACTN1/ITGAM	42
GO:0044389	ubiquitin-like protein ligase binding	73/2244	316/18367	4.2396444197028e-08	2.90680620525873e-06	EGFR/ERBB3/ABCB1/BAG2/TXNIP/LAPTM5/FZD6/HSPD1/HSP90AB1/UBE2T/ABI2/RPS27A/HSP90AA1/RPL5/NAE1/NFKBIA/WFS1/TRAF4/TRIM28/CCT2/TNFRSF1B/CALR/PSMD1/ISG15/TUBB/LYN/UBB/CEBPB/HSPA5/PRDX6/UBASH3B/PSMA3/TUBA1B/SLC25A5/STAT1/CCNB1/PA2G4/UBE2C/UBE2L6/ARRB2/YWHAE/GABARAPL1/RALA/BCL2/TRIOBP/RPL23/LRPPRC/RRAGA/TCP1/RPA2/TSG101/UBE2N/CXCR4/RBX1/VCP/HSPA8/TNFRSF14/NEDD8/HSPA9/CRK/GABARAPL2/STAT2/PARP9/JAK1/MDM2/CACYBP/JUN/UQCRC1/BID/HSPA1A/UBE2L3/BAG1/TPI1	73
GO:0016651	oxidoreductase activity, acting on NAD(P)H	30/2244	88/18367	7.74973652110854e-08	5.00085939038593e-06	CYBA/CYBB/DCXR/NCF1/NCF2/CYB5R1/NDUFA10/NDUFA6/NDUFV1/NDUFB9/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/NDUFS6/NDUFB10/NDUFA4/NDUFS5/NDUFB6/NDUFV2/NDUFA13/NDUFB4/NDUFS4/NDUFS3/NDUFA1/NDUFA3/NDUFC1/NDUFB3	30
GO:0003779	actin binding	92/2244	440/18367	1.27567007856556e-07	7.77450042325789e-06	EGFR/MYH10/SYNE2/CALD1/DAG1/CTNNAL1/FERMT1/FERMT2/S100A4/TMSB4X/SLC6A4/PDLIM1/TMSB10/AIF1/LCP1/PAWR/FMNL2/RAI14/PPP1R9A/LIMA1/COBLL1/COTL1/SCIN/EPS8L2/P4HB/MYO1C/COBL/DSTN/GMFG/CORO1A/DIAPH3/MYO7A/CNN3/OPHN1/SPTBN1/DMD/ARPC3/FXYD5/ITGB1/SORBS1/DST/EPS8/CTTN/LSP1/ARPC5L/PARVA/PTK2/MSN/FLNA/INF2/ENAH/ACTR2/TPM3/CAPG/MARCKS/ARPC1A/MYO1F/FLNB/WASF2/ARPC1B/WAS/LRRK2/RDX/CAP1/WASL/TRIOBP/VASP/CXCR4/EZR/GBP1/FMNL1/PALLD/TPM1/BCL7B/CFL1/ACTN1/RCSD1/MYO1G/ARPC4/WIPF1/IQGAP1/PARVG/HCLS1/PPP1R18/EPS8L1/CCDC88A/CAPZA1/CNN2/ACTR3/MSRB1/IQGAP2/FKBP15	92
GO:0031625	ubiquitin protein ligase binding	67/2244	297/18367	3.83122994303783e-07	2.21203118290131e-05	EGFR/ERBB3/ABCB1/BAG2/TXNIP/LAPTM5/FZD6/HSPD1/HSP90AB1/UBE2T/ABI2/RPS27A/HSP90AA1/RPL5/NAE1/NFKBIA/WFS1/TRAF4/TRIM28/CCT2/TNFRSF1B/CALR/PSMD1/ISG15/TUBB/LYN/UBB/HSPA5/PRDX6/UBASH3B/PSMA3/TUBA1B/SLC25A5/PA2G4/UBE2L6/ARRB2/YWHAE/GABARAPL1/RALA/BCL2/TRIOBP/RPL23/LRPPRC/RRAGA/TCP1/RPA2/TSG101/UBE2N/CXCR4/RBX1/VCP/HSPA8/TNFRSF14/NEDD8/HSPA9/CRK/GABARAPL2/JAK1/MDM2/CACYBP/JUN/UQCRC1/BID/HSPA1A/UBE2L3/BAG1/TPI1	67
GO:0008022	protein C-terminus binding	48/2244	189/18367	4.78044015593697e-07	2.62207142553143e-05	BCAM/FBLN1/CENPF/PPP1R9A/YAP1/MYO1C/PPARG/HRAS/MKI67/CORO1A/ID1/SIAH1/RAD51/PABPC1/MAD2L1/HIC2/DST/CDK7/NCF2/GPSM2/BAIAP2/DAB2/CD2AP/EML2/BRCA2/PCNA/DLG1/TOP2A/YEATS4/ITGB3BP/PHB/OPTN/TBL1X/PRDX3/CTNNB1/AGO2/NCL/JAK2/EZR/XRCC6/SAE1/COIL/PPP2CB/PRRC2C/SDCBP/CSK/TNFAIP3/PHB2	48
GO:0016853	isomerase activity	42/2244	158/18367	6.63201102072762e-07	3.46443623320867e-05	ISYNA1/P4HB/DEGS1/HSPD1/PTGES/RPIA/ECI1/PPIC/MIF/FKBP3/ECI2/PDIA6/ENOSF1/PPIB/ECH1/PPIA/PDIA3/ENOPH1/TOP2A/PDIA4/PGM1/PDIA5/PMM2/PPIL1/GLCE/PGM3/PPIH/TRUB2/CYP2J2/PIN4/GSTZ1/TOP1/FKBP2/PTGES2/FKBP4/PPIF/TBXAS1/DDT/FKBP5/PPIG/FKBP15/TPI1	42
GO:0003725	double-stranded RNA binding	25/2244	74/18367	1.11780661133376e-06	5.57379023924153e-05	VIM/TFRC/HSPD1/HSP90AB1/TLR3/TUBB4B/MSN/TUBA1B/MTDH/HMGB1/STAU1/MBNL1/ILF2/DDX1/AGO2/LRRFIP1/SLC3A2/OAS2/EIF4A1/ACTN1/DHX36/LSM14A/OAS1/TLR8/CLTC	25
GO:0097718	disordered domain specific binding	16/2244	36/18367	1.53379703386177e-06	7.31554498324504e-05	GJA1/GJA5/HSP90AB1/HSP90AA1/RRM1/PPIL1/HSPA2/NCOA3/CTNNB1/AP2A2/EZR/AP2M1/MDM2/FYN/HSPA1A/CLTC	16
GO:0033218	amide binding	81/2244	400/18367	2.68202555438424e-06	0.000122590918048313	MME/ENPEP/DHCR24/HLA-B/HLA-A/HLA-C/CTSV/FOLR1/CST3/ITM2C/ITGB2/SLC40A1/CD74/HLA-E/ACBD6/PPARG/PRLR/HLA-DRA/CD14/SLC19A1/LRPAP1/PTGES/HSP90AB1/IGF1R/PSAP/TYMS/PPIC/FKBP3/ECI2/ACADVL/NFKBIA/CLTA/HLA-DPA1/HLA-DRB1/FASN/PPIB/CALR/HLA-DPB1/DHFR/NUP214/PPIA/PFDN5/VDAC1/PLEKHA8/PPIL1/DBI/HLA-F/SRP14/PFDN1/LILRB2/TNPO1/CD36/PPIH/PFDN4/KDELR1/KPNA2/CLSTN1/VDAC2/KDELR2/FKBP2/CRIP1/PTGES2/FKBP4/PFDN6/HLA-DQB1/TAPBP/AP2M1/PFDN2/PPIF/TLR2/TPP1/TAP1/MGST1/ITGAM/FKBP5/CD1D/PPIG/SORL1/PHB2/CLTB/TOMM20	81
GO:0001618	virus receptor activity	24/2244	76/18367	6.95673949054685e-06	0.000305261728845196	EGFR/DPP4/DAG1/ITGB5/ITGAV/TFRC/BSG/RPSA/SLC52A1/ITGB1/CD46/SIVA1/SLC1A5/CDK1/SLC52A2/CD81/CXCR4/TNFRSF14/CD86/PLSCR1/SELPLG/CD4/HSPA1A/ITGA5	24
GO:0003697	single-stranded DNA binding	33/2244	123/18367	8.12997165821232e-06	0.000343022265733035	MCM3/MCM4/SMARCA1/MCM7/RAD51AP1/HSPD1/RAD51/MCM5/RPA3/MCM6/MCM2/NUCKS1/SAMHD1/CDC45/SMC2/BRCA2/NME1/POLR2H/PURA/RTF1/HMGB1/RAD50/SSBP1/LRPPRC/SSBP3/SMC4/HNRNPA1/RPA2/TOP1/RAD23B/POLR2G/DHX36/RAD23A	33
GO:0140272	exogenous protein binding	24/2244	77/18367	8.94632490080944e-06	0.000363485867266221	EGFR/DPP4/DAG1/ITGB5/ITGAV/TFRC/BSG/RPSA/SLC52A1/ITGB1/CD46/SIVA1/SLC1A5/CDK1/SLC52A2/CD81/CXCR4/TNFRSF14/CD86/PLSCR1/SELPLG/CD4/HSPA1A/ITGA5	24
GO:0008094	ATP-dependent activity, acting on DNA	30/2244	111/18367	1.76345781185905e-05	0.000690897578431922	HELLS/MCM3/MCM4/SMARCA1/MCM7/RAD51/XRCC2/MCM5/NAV2/MCM6/CDK7/MCM2/RAD51C/SMARCA2/ATAD5/RFC3/CHD7/RFC4/TOP2A/G3BP1/MSH6/SMC3/RFC2/RAD50/DDX1/RUVBL1/RFC1/RUVBL2/XRCC6/DHX36	30
GO:0015399	primary active transmembrane transporter activity	42/2244	181/18367	2.66121925100709e-05	0.00100667500632923	SLC26A2/ATP6V1C2/ABCB1/CYB5A/NDUFA10/COX6A1/NDUFA6/ABCA1/NDUFV1/NDUFB9/ATP2B1/UQCR10/NDUFB7/NDUFC2/NDUFS8/NDUFB2/NDUFA5/NDUFA8/ATP13A3/NDUFS6/NDUFB10/NDUFA4/NDUFS5/CYC1/NDUFB6/NDUFV2/NDUFA13/NDUFB4/TAPBP/NDUFS4/NDUFS3/NDUFA1/COX5A/TAP1/NDUFA3/NDUFC1/UQCRH/ATP6V0D1/UQCRC1/NDUFB3/UQCRFS1/TOMM20	42
GO:0050786	RAGE receptor binding	7/2244	10/18367	3.45074713824587e-05	0.00126182320355191	S100A4/S100A8/S100A9/S100A13/S100A12/FPR1/HMGB1	7
GO:0042288	MHC class I protein binding	10/2244	20/18367	4.18901610950396e-05	0.00148237118455672	HLA-E/TUBB4B/TUBB/LILRB2/BCAP31/VCP/PILRA/TAPBP/LILRB1/TAP1	10
GO:0098631	cell adhesion mediator activity	19/2244	59/18367	4.54062775584827e-05	0.00155658395255174	BCAM/DSP/DSG2/KRT18/PDLIM1/TRIM29/JAM3/BSG/RPSA/CNN3/ITGB1/PKP3/BAIAP2/ANXA2/DSC2/PKP2/CD47/JUP/PALLD	19
GO:0016859	cis-trans isomerase activity	15/2244	41/18367	5.41345388874393e-05	0.00179956330786427	DEGS1/PPIC/FKBP3/PPIB/PPIA/PPIL1/PPIH/PIN4/GSTZ1/FKBP2/FKBP4/PPIF/FKBP5/PPIG/FKBP15	15
GO:0051020	GTPase binding	59/2244	291/18367	5.6078059892382e-05	0.00180934210888068	RASA1/RHOBTB3/LCP1/FMNL2/PPP1R9A/SOD1/BNIP3/CHML/MYO1C/ARHGDIB/DIAPH3/EXPH5/FNBP1L/SPTBN1/ERRFI1/ABI2/MICALL1/HSP90AA1/NCF2/EPS8/CLTA/BIRC5/DVL3/RANBP1/ABCA1/STOML2/FLNA/INF2/ANXA2/CAV1/LSM2/YIPF2/ECT2/GOLGA4/OPTN/NXT1/TNPO1/WAS/NUTF2/LRRK2/RANGRF/TRIOBP/ERC1/DMXL2/CCDC186/RRAGC/YIPF1/FMNL1/TRIP11/IQGAP1/TNFAIP1/IFT20/AKAP13/AIMP1/RASSF5/PAK2/RIN3/SORL1/IQGAP2	59
GO:0003714	transcription corepressor activity	42/2244	187/18367	5.97364788507559e-05	0.00187231192283655	RBFOX2/TFAP2A/PAWR/TLE1/GMNN/PPP1R13L/YAP1/CCND1/FHL2/DNMT3A/MTA3/KCTD1/TRIM28/SIAH2/CBX4/C1QBP/HSBP1L1/EID2/EZH2/PFDN5/BRD7/PHB/PA2G4/KDM5B/ATN1/TBL1X/BASP1/RUVBL2/TSG101/SAP18/SRSF2/TRIM22/ZNF451/RERE/SF1/RCOR1/PARP9/BTG2/PARP14/APEX1/EID1/HSPA1A	42
GO:0003712	transcription coregulator activity	89/2244	489/18367	6.8011612678477e-05	0.00207246497523026	MAGED1/RBFOX2/PAGE4/TFAP2A/PDLIM1/VGLL1/PAWR/ARID5B/TLE1/GMNN/PTPN14/PPP1R13L/RBPMS/YAP1/CCND1/FHL2/HMGA1/NPM1/DNMT3A/MTA3/KCTD1/NUCKS1/SMARCA2/TRIM28/BRD4/SIAH2/CBX4/ARID3A/PIR/C1QBP/MYCBP/MED19/HSBP1L1/EID2/EZH2/PFDN5/USP22/MTDH/TRIM24/ACTL6A/BRD7/FUS/PHB/PSIP1/PA2G4/KDM5B/HMGB1/SMARCD1/DCAF6/PCBD1/ATN1/DDX1/NCOA3/JUP/WDR77/SMARCE1/TBL1X/TAF11/MED16/RUVBL1/CTNNB1/SND1/BASP1/RUVBL2/TSG101/PARK7/SAP18/SRSF2/NUPR1/TRIM22/PMF1/ZNF451/RERE/SF1/SMARCC1/LMO2/ACTN1/TRIP11/RCOR1/PARP9/EDF1/BTG2/PARP14/APEX1/EID1/HTATIP2/TRIM38/HSPA1A/UBE2L3	89
GO:0004298	threonine-type endopeptidase activity	8/2244	14/18367	7.43515736561778e-05	0.00220442368380614	PSMB5/PSMB1/PSMB6/PSMB9/PSMB7/PSMB8/PSMB2/PSMB4	8
GO:0042608	T cell receptor binding	7/2244	11/18367	8.48358713134458e-05	0.00244907765344342	HLA-A/HLA-E/HLA-DRA/HLA-DRB1/DOCK2/EPS8L1/FYN	7
GO:0042277	peptide binding	63/2244	321/18367	8.72035021692365e-05	0.00245287799691417	MME/ENPEP/DHCR24/HLA-B/HLA-A/HLA-C/CTSV/CST3/ITM2C/ITGB2/SLC40A1/CD74/HLA-E/PPARG/PRLR/HLA-DRA/CD14/LRPAP1/PTGES/HSP90AB1/IGF1R/PPIC/NFKBIA/CLTA/HLA-DPA1/HLA-DRB1/PPIB/CALR/HLA-DPB1/NUP214/PPIA/PFDN5/PPIL1/HLA-F/SRP14/PFDN1/LILRB2/TNPO1/CD36/PPIH/PFDN4/KDELR1/KPNA2/CLSTN1/KDELR2/CRIP1/PTGES2/PFDN6/HLA-DQB1/TAPBP/AP2M1/PFDN2/PPIF/TLR2/TPP1/TAP1/MGST1/ITGAM/CD1D/PPIG/SORL1/CLTB/TOMM20	63
GO:0051015	actin filament binding	46/2244	217/18367	0.000120377419909739	0.00330135074102461	EGFR/MYH10/SYNE2/CTNNAL1/FERMT1/FERMT2/SLC6A4/AIF1/LCP1/FMNL2/PPP1R9A/LIMA1/COTL1/SCIN/MYO1C/DSTN/CORO1A/MYO7A/SPTBN1/DMD/ARPC3/CTTN/ARPC5L/FLNA/ACTR2/TPM3/CAPG/MARCKS/ARPC1A/MYO1F/FLNB/ARPC1B/TRIOBP/EZR/FMNL1/TPM1/CFL1/ACTN1/RCSD1/MYO1G/ARPC4/IQGAP1/HCLS1/CAPZA1/ACTR3/IQGAP2	46
GO:0098632	cell-cell adhesion mediator activity	16/2244	49/18367	0.000148193903196242	0.00396509053186044	DSP/DSG2/KRT18/PDLIM1/TRIM29/JAM3/BSG/CNN3/PKP3/BAIAP2/ANXA2/DSC2/PKP2/CD47/JUP/PALLD	16
GO:0042287	MHC protein binding	14/2244	40/18367	0.000165744989567837	0.00432910127514088	CD74/HLA-E/TUBB4B/TUBB/LILRB2/CLEC7A/CD81/BCAP31/VCP/PILRA/TAPBP/LILRB1/TAP1/CD4	14
GO:0016829	lyase activity	42/2244	196/18367	0.000181527048374236	0.00446816876701168	GLDC/HACD3/MGST3/GGCT/ECHDC2/ECHS1/RPS3/ECI1/APMAP/PAICS/CA8/ENOSF1/UMPS/FASN/FH/UXS1/GGCX/PISD/GOT1/HMGB1/ILVBL/ALAD/RNASET2/PCBD1/PDXDC1/PTS/ADSL/XRCC6/UROD/PARK7/PTGES2/ARMT1/AZIN1/BST1/TBXAS1/HACD4/GLO1/DDT/HADHB/CYP1B1/RNASE2/TPI1	42
GO:0035325	Toll-like receptor binding	7/2244	12/18367	0.000182064878323289	0.00446816876701168	S100A8/S100A9/CD36/LY96/SYK/TLR2/UNC93B1	7
GO:0017116	single-stranded DNA helicase activity	10/2244	23/18367	0.000183288600287626	0.00446816876701168	MCM3/MCM4/MCM7/RAD51/MCM5/MCM6/MCM2/RFC3/RFC4/RFC2	10
GO:0042605	peptide antigen binding	13/2244	36/18367	0.000196980264638894	0.00469755109367102	DHCR24/HLA-B/HLA-A/HLA-C/HLA-E/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-F/HLA-DQB1/TAPBP/TAP1	13
GO:0005525	GTP binding	70/2244	377/18367	0.000213501181570354	0.00498320842941868	RHOBTB3/TGM2/GNAS/RND3/HRAS/HSP90AB1/RHOBTB1/TUBA1C/AK3/GNA12/GNAI1/GNAI2/RAB25/TUBB4B/RAB38/SAMHD1/RAN/EHD3/ARL1/RHOC/RRAS2/GIMAP4/GNA11/TUBB/NME1/TUBA1B/RAB17/GIMAP7/RHOA/GBP2/RHOD/ARF4/IFI44L/RHEB/RAC2/ARFRP1/TUBG1/ERAL1/LRRK2/ARHGAP5/RAB13/EIF5B/RALA/GNL1/RRAGA/ARL15/MX1/RHOB/RHOG/SRPRB/RAB32/RRAGC/DRG1/RAB6A/RTCB/EEF1A1/GBP4/GBP1/CDC42/TUFM/TUBA1A/EIF5/MX2/ARL2/ARL4A/OLA1/GBP5/GIMAP1/ARF5/RAB8B	70
GO:0016860	intramolecular oxidoreductase activity	16/2244	51/18367	0.000250230312734241	0.00571880527228046	P4HB/PTGES/RPIA/ECI1/MIF/ECI2/PDIA6/ECH1/PDIA3/ENOPH1/PDIA4/PDIA5/PTGES2/TBXAS1/DDT/TPI1	16
GO:0051861	glycolipid binding	11/2244	28/18367	0.000258920847482816	0.00579665652425815	PSAP/GPAA1/CLN3/LYN/MANF/PLEKHA8/HSPA2/SELL/PPT1/CLEC4E/TPP1	11
GO:0097110	scaffold protein binding	19/2244	67/18367	0.000299836162873429	0.00657840541344303	DSP/KRT18/KRT8/VIM/DYNLL2/PSAP/HSP90AA1/BAIAP2/IL6ST/LYN/NCK2/YWHAE/CAV2/XRCC6/PARK7/CRK/SYK/FYN/CD163	19
GO:0030674	protein-macromolecule adaptor activity	57/2244	296/18367	0.000307813707397413	0.00662101249048945	COL14A1/SYNE2/DLG5/OBSL1/FRMD4A/AP1M2/ANK3/DDB1/HOMER1/AP1S3/STON1/ABI2/SORBS1/CBX5/EPS8/BAIAP2/AP1S2/DAB2/ANKRD9/SLC9A1/AP1S1/KLHDC2/CAV1/SUN1/ST13/NCK2/MPP7/OPTN/RAD50/PEF1/LRRK2/JUP/CAV2/AP2A2/SKP1/KLF4/GOSR1/DOK2/FKBP4/HSPA8/TRIM22/AP2M1/CRK/PTPN11/PSMC6/CUX1/ARPC4/VAMP8/IQGAP1/SPAG9/SDCBP/PDCD6/PPP4R2/STX11/AKAP13/STX10/PAG1	57
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	17/2244	57/18367	0.000319395978182953	0.00673802669359038	P4HB/PCYOX1/PDIA6/PDIA3/GLRX5/PDIA4/PDIA5/TMX2/GLRX/PRDX3/IFI30/TXN2/TXNL1/GLRX3/TXN/SCO2/MSRB1	17
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	13/2244	38/18367	0.000364850743685605	0.00755172199666243	PPIC/FKBP3/PPIB/PPIA/PPIL1/PPIH/PIN4/FKBP2/FKBP4/PPIF/FKBP5/PPIG/FKBP15	13
GO:0016504	peptidase activator activity	14/2244	43/18367	0.000392723389955016	0.00797810294038246	FBLN1/PCOLCE2/APP/PYCARD/BAD/PSMD14/CAV1/CASP1/PSME2/ADRM1/PSME1/VCP/CTSH/CTSC	14
GO:0070628	proteasome binding	8/2244	17/18367	0.000428510443654728	0.00854683557616793	ID1/PSMD14/WFS1/USP14/PSMG1/ADRM1/RAD23B/RAD23A	8
GO:0043021	ribonucleoprotein complex binding	33/2244	149/18367	0.000458787257486439	0.00898731466897542	RPSA/NPM1/EIF1/NEAT1/SNRPG/RPN2/CBX5/UNG/C1QBP/PRMT7/NME1/HSPA5/EZH2/SNRPD1/MRPS27/ERAL1/PPIH/CCDC47/SNRPB/SNRPD2/TIMM50/SND1/MALSU1/RPLP1/ETF1/SBDS/NAA10/STRAP/SERBP1/MDM2/OLA1/SNRPC/SRP9	33
GO:0016209	antioxidant activity	22/2244	86/18367	0.000515129412602628	0.00991398185307163	MGST3/PRDX4/PRDX2/GPX8/SOD1/PRDX1/S100A9/SOD3/PRDX5/PTGES/GSTP1/SOD2/GPX1/SESN1/PRDX6/GPX3/GLRX/PRDX3/GSTZ1/PARK7/TXN/MGST1	22
GO:0060090	molecular adaptor activity	67/2244	369/18367	0.000546070637095558	0.0103282670498936	COL14A1/SYNE2/DLG5/OBSL1/FRMD4A/AP1M2/ANK3/DDB1/PDE4DIP/HOMER1/AP1S3/STON1/ABI2/SORBS1/CBX5/EPS8/BAIAP2/AP1S2/DAB2/ANKRD9/SLC9A1/AP1S1/DLG1/KLHDC2/CAV1/SUN1/ST13/NCK2/PSMG1/MPP7/PKP2/ISCU/OPTN/RAD50/SMARCD1/PEF1/LRRK2/JUP/CAV2/AP2A2/SKP1/KLF4/RUVBL2/GOSR1/SCIMP/DOK2/FKBP4/HSPA8/TRIM22/AP2M1/CRK/LAMTOR4/PTPN11/PSMC6/CUX1/ARPC4/VAMP8/IQGAP1/SPAG9/SDCBP/PDCD6/PPP4R2/STX11/AKAP13/STX10/AKAP9/PAG1	67
GO:0003924	GTPase activity	62/2244	337/18367	0.000608861499304854	0.0113206960124987	RASA1/RHOBTB3/GNAS/RND3/HRAS/ARHGDIB/RHOBTB1/TUBA1C/GNA12/GNAI1/GNAI2/RAB25/TUBB4B/RAB38/RAN/ARL1/RHOC/RRAS2/GNA11/TUBB/TUBA1B/RGS2/RAB17/GIMAP7/RHOA/GBP2/RHOD/ARF4/RHEB/RAC2/ARFRP1/TUBG1/LRRK2/ARHGAP5/RAB13/EIF5B/RALA/GNL1/RRAGA/ARL15/MX1/RHOB/RHOG/RAB32/RRAGC/DRG1/RAB6A/EEF1A1/GBP4/RGS10/GBP1/CDC42/TUFM/TUBA1A/MX2/ARL2/ARL4A/GBP5/RGS19/RGS18/ARF5/RAB8B	62
GO:0019001	guanyl nucleotide binding	71/2244	398/18367	0.000635355313039426	0.0114108494314117	RHOBTB3/TGM2/GNAS/RND3/HRAS/SLC19A1/HSP90AB1/RHOBTB1/TUBA1C/AK3/GNA12/GNAI1/GNAI2/RAB25/TUBB4B/RAB38/SAMHD1/RAN/EHD3/ARL1/RHOC/RRAS2/GIMAP4/GNA11/TUBB/NME1/TUBA1B/RAB17/GIMAP7/RHOA/GBP2/RHOD/ARF4/IFI44L/RHEB/RAC2/ARFRP1/TUBG1/ERAL1/LRRK2/ARHGAP5/RAB13/EIF5B/RALA/GNL1/RRAGA/ARL15/MX1/RHOB/RHOG/SRPRB/RAB32/RRAGC/DRG1/RAB6A/RTCB/EEF1A1/GBP4/GBP1/CDC42/TUFM/TUBA1A/EIF5/MX2/ARL2/ARL4A/OLA1/GBP5/GIMAP1/ARF5/RAB8B	71
GO:0032561	guanyl ribonucleotide binding	71/2244	398/18367	0.000635355313039426	0.0114108494314117	RHOBTB3/TGM2/GNAS/RND3/HRAS/SLC19A1/HSP90AB1/RHOBTB1/TUBA1C/AK3/GNA12/GNAI1/GNAI2/RAB25/TUBB4B/RAB38/SAMHD1/RAN/EHD3/ARL1/RHOC/RRAS2/GIMAP4/GNA11/TUBB/NME1/TUBA1B/RAB17/GIMAP7/RHOA/GBP2/RHOD/ARF4/IFI44L/RHEB/RAC2/ARFRP1/TUBG1/ERAL1/LRRK2/ARHGAP5/RAB13/EIF5B/RALA/GNL1/RRAGA/ARL15/MX1/RHOB/RHOG/SRPRB/RAB32/RRAGC/DRG1/RAB6A/RTCB/EEF1A1/GBP4/GBP1/CDC42/TUFM/TUBA1A/EIF5/MX2/ARL2/ARL4A/OLA1/GBP5/GIMAP1/ARF5/RAB8B	71
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	16/2244	55/18367	0.000644915829304948	0.0114108494314117	MGST3/PRDX4/PRDX2/GPX8/PRDX1/PRDX5/PTGES/GSTP1/GPX1/SESN1/PRDX6/GPX3/PRDX3/GSTZ1/PARK7/MGST1	16
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	15/2244	50/18367	0.000660070553027515	0.0114187211824193	CDKN1C/CCND1/CCNE1/CKS1B/CCNB2/CDK4/CCNB1/HEXIM1/CDKN2A/CKS2/CCNG1/MNAT1/CCNC/CCND3/CCNL1	15
GO:0004602	glutathione peroxidase activity	9/2244	22/18367	0.000666178811007143	0.0114187211824193	MGST3/GPX8/PTGES/GSTP1/GPX1/PRDX6/GPX3/GSTZ1/MGST1	9
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	6/2244	11/18367	0.000882304885018843	0.0148905916748565	DSP/DSG2/DSC2/PKP2/CD47/JUP	6
GO:0051087	chaperone binding	25/2244	107/18367	0.000954044541781814	0.0158573767020401	LRP2/HLA-B/BAG2/SOD1/DNAJC9/HSPD1/HSPE1/DNAJB4/BIRC5/CALR/TBCA/HSPA5/ST13/GRN/HSPA2/PFDN4/AHSA1/DNAJB9/HSPA8/PFDN6/GRPEL1/CTSC/DNAJB6/ERP29/BAG1	25
GO:0042393	histone binding	47/2244	244/18367	0.000983413899315975	0.016101567873875	MORC4/CTSL/RBBP7/NASP/DNAJC9/NPM1/CKS1B/CBX5/MCM2/SMARCA2/BRD4/ATAD2/CBX4/NCAPD3/PRMT7/YEATS4/STAT1/SPIN1/TRIM24/BRD7/ASF1B/GRWD1/USP15/MSH6/SSRP1/KDM5B/VRK1/HAT1/CKS2/NPM3/TBL1X/ING2/NAP1L4/JAK2/SET/COPRS/SUZ12/BAZ1B/SMARCC1/PWP1/PIH1D1/DEK/PARP9/USP3/ANP32B/CD1D/NAP1L1	47
GO:0001846	opsonin binding	7/2244	15/18367	0.00105922235502669	0.0168578081135079	ITGAV/ITGB2/CALR/C1QBP/PHB/CD93/ITGAM	7
GO:0035615	clathrin adaptor activity	8/2244	19/18367	0.00106334067881209	0.0168578081135079	AP1M2/AP1S3/STON1/AP1S2/DAB2/AP1S1/AP2A2/AP2M1	8
GO:0015036	disulfide oxidoreductase activity	13/2244	42/18367	0.0010757033436149	0.0168578081135079	P4HB/PDIA6/PDIA3/GLRX5/PDIA4/PDIA5/TMX2/GLRX/TXN2/TXNL1/GLRX3/TXN/SCO2	13
GO:0000287	magnesium ion binding	43/2244	221/18367	0.00128247306242638	0.0198151119645316	WEE1/EPHX2/NUDT8/MAST4/COMT/GNAI1/FEN1/IDH2/S100P/ATP10D/RAN/CIB2/ENOSF1/DCTPP1/IDH1/NME1/SRPK1/ENOPH1/TOP2A/DUT/AASDHPPT/PGP/STK26/PGM1/MSH6/RHEB/PGM3/ILVBL/LRRK2/TDG/RRAGC/GLUL/PRPSAP1/IRAK3/PLSCR1/TKT/PPA1/UBA2/DHX36/NUDT5/PDCD6/STK4/RPS6KA1	43
GO:0051537	2 iron, 2 sulfur cluster binding	9/2244	24/18367	0.0013946060282007	0.0212483724018913	CISD1/GLRX5/ISCU/FDX1/ISCA1/FXN/NDUFV2/CIAPIN1/UQCRFS1	9
GO:0140678	molecular function inhibitor activity	28/2244	128/18367	0.00145279449508531	0.0218317200151861	RASA1/TXNIP/ANXA3/OAZ1/ID4/ID1/RPL5/ANXA5/PACSIN3/RPS7/MDFI/ID3/NEDD4/ANXA2/CAV1/PURA/DFFA/RPL37/LRRK2/BCL2/RPL23/COMMD1/PRPSAP1/RPS15/PHPT1/GCHFR/ENSA/PARP9	28
GO:0140312	cargo adaptor activity	8/2244	20/18367	0.0015837997805195	0.0234787616112147	AP1M2/AP1S3/STON1/AP1S2/DAB2/AP1S1/AP2A2/AP2M1	8
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	10/2244	29/18367	0.00160889619239486	0.0235327883074288	DHCR24/AKR1B1/TECR/FASN/TM7SF2/BLVRB/DPYD/PTGES2/TBXAS1/BLVRA	10
GO:0031267	small GTPase binding	48/2244	259/18367	0.00202714938663513	0.0292603010149833	RHOBTB3/FMNL2/SOD1/CHML/MYO1C/ARHGDIB/DIAPH3/EXPH5/ERRFI1/ABI2/MICALL1/NCF2/EPS8/BIRC5/DVL3/RANBP1/ABCA1/FLNA/INF2/ANXA2/CAV1/LSM2/YIPF2/ECT2/GOLGA4/OPTN/NXT1/TNPO1/WAS/NUTF2/LRRK2/RANGRF/TRIOBP/ERC1/DMXL2/CCDC186/YIPF1/FMNL1/TRIP11/IQGAP1/TNFAIP1/IFT20/AKAP13/RASSF5/PAK2/RIN3/SORL1/IQGAP2	48
GO:0003678	DNA helicase activity	18/2244	72/18367	0.00211912177635236	0.0301906050475135	MCM3/MCM4/MCM7/RAD51/MCM5/NAV2/MCM6/MCM2/RFC3/CHD7/RFC4/G3BP1/RFC2/RAD50/RUVBL1/RUVBL2/XRCC6/DHX36	18
GO:0001848	complement binding	8/2244	21/18367	0.00228692178223916	0.0321635025014918	CD59/ITGB2/CALR/C1QBP/PHB/C5AR1/CD93/ITGAM	8
GO:0045309	protein phosphorylated amino acid binding	15/2244	56/18367	0.00234854176484287	0.0326120293168687	RASA1/SH2D3A/YES1/NEDD4/FGR/RTF1/NCK2/YWHAE/HCK/PTPN6/CRK/SYK/PTPN11/SOCS3/SH3BP2	15
GO:0004601	peroxidase activity	14/2244	51/18367	0.002528854212847	0.033882616929147	MGST3/PRDX4/PRDX2/GPX8/PRDX1/PRDX5/PTGES/GSTP1/GPX1/PRDX6/GPX3/PRDX3/GSTZ1/MGST1	14
GO:0019902	phosphatase binding	38/2244	196/18367	0.00252897706421218	0.033882616929147	MET/EGFR/KCNN4/SH2D4A/PPP1R9A/SOD1/PARD3/HSP90B1/SH3YL1/PPP1R35/BAD/SLC9A1/PTK2/DLG1/STAT1/CARHSP1/BOD1/LILRB2/STAU1/PTPN1/JUP/BCL2/CTNNB1/RPA2/KIFAP3/VCP/SYK/SNX3/LILRB1/ENSA/IQGAP1/JAK1/CTSC/PPP1R18/C20orf27/EIF4EBP1/CSK/PPP1R15A	38
GO:0003713	transcription coactivator activity	48/2244	262/18367	0.00257813968117857	0.033882616929147	MAGED1/PAGE4/PDLIM1/VGLL1/ARID5B/RBPMS/YAP1/HMGA1/NPM1/MTA3/NUCKS1/SMARCA2/TRIM28/BRD4/MYCBP/USP22/MTDH/TRIM24/ACTL6A/BRD7/FUS/HMGB1/SMARCD1/DCAF6/PCBD1/NCOA3/JUP/WDR77/SMARCE1/TAF11/MED16/RUVBL1/CTNNB1/TSG101/PARK7/NUPR1/TRIM22/PMF1/RERE/SMARCC1/LMO2/ACTN1/TRIP11/EDF1/APEX1/HTATIP2/TRIM38/UBE2L3	48
GO:0140097	catalytic activity, acting on DNA	43/2244	229/18367	0.00260899164261513	0.033882616929147	HELLS/DNMT1/MCM3/MCM4/SMARCA1/MCM7/RPS3/RAD51/XRCC2/MCM5/NAV2/FEN1/MCM6/CDK7/LIG1/DNMT3A/MCM2/RAD51C/RAD1/SMARCA2/UNG/ATAD5/RFC3/PCNA/NME1/CHD7/RFC4/TOP2A/G3BP1/MSH6/SMC3/RFC2/RAD50/DDX1/RUVBL1/RFC1/MGMT/TDG/RUVBL2/TOP1/XRCC6/DHX36/APEX1	43
GO:0016835	carbon-oxygen lyase activity	19/2244	79/18367	0.00261294990188134	0.033882616929147	HACD3/ECHDC2/ECHS1/RPS3/ECI1/CA8/ENOSF1/FASN/FH/ALAD/PCBD1/PTS/XRCC6/PARK7/TBXAS1/HACD4/HADHB/CYP1B1/TPI1	19
GO:0044325	transmembrane transporter binding	28/2244	133/18367	0.00263772184818241	0.033882616929147	TCAF1/TSPO/BAG2/ANK3/PPP1R9A/HOMER1/HSP90AB1/PYCARD/YES1/SLC5A3/FLNA/LYN/DLG1/CAV1/VDAC1/PKP2/YWHAE/LRRK2/GOPC/RANGRF/CTNNB1/AP2M1/USP10/ACTN1/PHPT1/AKAP9/FYN/SLC8A1	28
GO:0038187	pattern recognition receptor activity	9/2244	26/18367	0.00265624891149192	0.033882616929147	COLEC12/FCN1/CD14/CD36/CLEC7A/LY96/CLEC4E/TLR2/TLR8	9
GO:0022804	active transmembrane transporter activity	69/2244	406/18367	0.0027193200117645	0.0342884373897201	SLC26A2/SLC22A11/SLC38A1/SLC13A4/ATP6V1C2/SLC6A4/SLC16A12/ABCB1/CYB5A/SLC16A4/SLC13A3/SLC19A1/SLC16A1/SLC25A4/SLC16A2/SLC5A6/SLC12A4/SLC1A3/SLC25A3/SLC9A1/NDUFA10/SLC5A3/COX6A1/NDUFA6/ABCA1/NDUFV1/ANKH/SLC25A5/NDUFB9/ATP2B1/UQCR10/NDUFB7/SLC11A1/NDUFC2/NDUFS8/SLC1A5/NDUFB2/NDUFA5/NDUFA8/ATP13A3/NDUFS6/NDUFB10/NDUFA4/NDUFS5/CYC1/SLC12A9/NDUFB6/NDUFV2/NDUFA13/NDUFB4/TAPBP/SLC3A2/SLC25A1/NDUFS4/NDUFS3/SLC16A3/NDUFA1/COX5A/TAP1/NDUFA3/NDUFC1/UQCRH/ATP6V0D1/UQCRC1/NDUFB3/UQCRFS1/SLC8A1/SLC25A6/TOMM20	69
GO:0005200	structural constituent of cytoskeleton	23/2244	103/18367	0.00279802464251616	0.0348799208277298	DSP/VIM/ANK3/ACTB/SPTBN1/TUBA1C/DMD/ARPC3/KRT19/TUBB4B/HLA-DRB1/CD2AP/MSN/TUBB/TUBA1B/YEATS4/ACTR2/TUBG1/ARPC1B/TUBA1A/TPM1/ARPC4/ACTR3	23
GO:0015035	protein-disulfide reductase activity	11/2244	37/18367	0.00364171739963726	0.0448242663054055	P4HB/PDIA6/PDIA3/GLRX5/PDIA4/PDIA5/GLRX/TXN2/GLRX3/TXN/SCO2	11
GO:0050699	WW domain binding	10/2244	32/18367	0.00367746943253099	0.0448242663054055	TCEAL4/TP63/TRAF4/NDFIP2/ENAH/TCEAL8/KIF20B/DAZAP2/PRRG4/NFE2	10
GO:0098641	cadherin binding involved in cell-cell adhesion	7/2244	18/18367	0.00375944691078464	0.0451750308452918	KRT18/PDLIM1/TRIM29/CNN3/PKP3/BAIAP2/ANXA2	7
GO:0017124	SH3 domain binding	27/2244	130/18367	0.00378860787398983	0.0451750308452918	LRP2/GJA1/CYBA/SH3BGRL2/BCAR1/NCF1/DOCK1/ERRFI1/ABI2/GPX1/FUT8/CD2AP/SH3BGRL/LYN/ENAH/WASF2/WAS/PTPN6/VASP/RAPGEF1/CRK/PTTG1/PLSCR1/WIPF1/HCLS1/SH3KBP1/SH3BP2	27
GO:0032395	MHC class II receptor activity	5/2244	10/18367	0.00401363922167163	0.0473436798513309	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DQB1/HLA-DQA2	5
GO:0004386	helicase activity	31/2244	156/18367	0.00409293301578549	0.0476850492173026	HELLS/MCM3/MCM4/SMARCA1/MCM7/RAD51/MCM5/NAV2/MCM6/MCM2/SMARCA2/RFC3/DDX3Y/CHD7/RFC4/MOV10/G3BP1/RFC2/RAD50/DDX1/RUVBL1/RUVBL2/DDX56/XRCC6/DHX32/EIF4A1/DDX24/DDX18/DHX36/DDX52/DDX46	31
GO:0051219	phosphoprotein binding	20/2244	88/18367	0.00412951656849931	0.0476850492173026	RASA1/SH2D3A/YES1/CBX4/LYN/UBASH3B/NEDD4/FGR/RTF1/NCK2/YWHAE/HCK/PTPN6/RRAGA/CRK/SYK/PTPN11/SOCS3/PIH1D1/SH3BP2	20
GO:0019903	protein phosphatase binding	30/2244	150/18367	0.0042510240524593	0.0485768060994568	MET/EGFR/KCNN4/PPP1R9A/SOD1/PARD3/HSP90B1/BAD/SLC9A1/PTK2/STAT1/BOD1/LILRB2/STAU1/PTPN1/JUP/BCL2/CTNNB1/RPA2/KIFAP3/VCP/SNX3/LILRB1/ENSA/IQGAP1/JAK1/C20orf27/EIF4EBP1/CSK/PPP1R15A	30
GO:0005158	insulin receptor binding	8/2244	23/18367	0.00440583523134808	0.0498268169978232	IGF1R/SORBS1/SNX4/IGF2/PDPK1/PTPN1/PTPN11/CCDC88A	8
GO:0043236	laminin binding	9/2244	28/18367	0.00468362122563172	0.0524278824950816	BCAM/ITGA6/TINAGL1/DAG1/CTSS/GPC1/LGALS1/RPSA/ITGB1	9
GO:0001784	phosphotyrosine residue binding	12/2244	44/18367	0.00530634564592508	0.0585387911175451	RASA1/SH2D3A/YES1/FGR/NCK2/HCK/PTPN6/CRK/SYK/PTPN11/SOCS3/SH3BP2	12
GO:0005080	protein kinase C binding	14/2244	55/18367	0.00533626172447996	0.0585387911175451	DSP/ITGAV/PARD6B/HINT1/FLNA/C1QBP/TOP2A/MARCKS/PKP2/PLEK/SRSF2/HSPB1/GLRX3/CCDC88A	14
GO:0070003	threonine-type peptidase activity	8/2244	24/18367	0.00591144983292177	0.0640181856782815	PSMB5/PSMB1/PSMB6/PSMB9/PSMB7/PSMB8/PSMB2/PSMB4	8
GO:0016831	carboxy-lyase activity	10/2244	34/18367	0.00595246576042362	0.0640181856782815	PAICS/UMPS/UXS1/GGCX/PISD/GOT1/PDXDC1/UROD/AZIN1/DDT	10
GO:0050840	extracellular matrix binding	14/2244	56/18367	0.00633216837769233	0.0674406670905679	BCAM/ADGRG1/ITGA6/TINAGL1/DAG1/CTSS/SMOC1/ITGAV/GPC1/LGALS1/RPSA/ITGB1/ANXA2/TGFBI	14
GO:0004715	non-membrane spanning protein tyrosine kinase activity	12/2244	45/18367	0.00644771402230088	0.0680109834852314	WEE1/YES1/PTK2/LYN/FGR/HCK/JAK2/BAZ1B/SYK/JAK1/FYN/CSK	12
GO:1990226	histone methyltransferase binding	5/2244	11/18367	0.0066230845022156	0.0691954637993382	HSP90AB1/NOP56/CTNNB1/CBX1/CBX3	5
GO:0003684	damaged DNA binding	16/2244	68/18367	0.00686391922223917	0.0697196239518183	DDB1/RPS3/TP63/RPA3/FEN1/RAD1/UNG/PCNA/MSH6/HMGB1/RPA2/TDG/RAD23B/XRCC6/RAD23A/APEX1	16
GO:0051536	iron-sulfur cluster binding	16/2244	68/18367	0.00686391922223917	0.0697196239518183	RPS3/CISD1/NUBP2/NDUFV1/GLRX5/NDUFS8/ISCU/NFU1/FDX1/ISCA1/FXN/DPYD/NDUFV2/GLRX3/CIAPIN1/UQCRFS1	16
GO:0051540	metal cluster binding	16/2244	68/18367	0.00686391922223917	0.0697196239518183	RPS3/CISD1/NUBP2/NDUFV1/GLRX5/NDUFS8/ISCU/NFU1/FDX1/ISCA1/FXN/DPYD/NDUFV2/GLRX3/CIAPIN1/UQCRFS1	16
GO:0042169	SH2 domain binding	11/2244	40/18367	0.00698027616371684	0.0702510362531869	DAG1/PTK2/ARHGAP5/PTPN6/JAK2/LAT2/CRK/SYK/LILRB1/CCDC88A/PAG1	11
GO:0016018	cyclosporin A binding	7/2244	20/18367	0.00735053172756946	0.0728137671918734	PPIC/PPIB/PPIA/PPIL1/PPIH/PPIF/PPIG	7
GO:0032182	ubiquitin-like protein binding	23/2244	111/18367	0.00736766468395438	0.0728137671918734	CKS1B/N4BP2/PELP1/CBX4/NEDD4/TOP2A/UBXN2A/DCUN1D5/UBE2L6/CKS2/ADRM1/TDG/TSG101/UBE2N/CXCR4/RAD23B/UCHL3/HSPB1/UBA2/SERBP1/MDM2/RAD23A/TNFAIP3	23
GO:0035925	mRNA 3'-UTR AU-rich region binding	8/2244	25/18367	0.0077779173274978	0.076181922395224	RBMS3/ZFP36/ZFP36L2/EXOSC8/KHSRP/HNRNPA0/EXOSC9/DHX36	8
GO:0061134	peptidase regulator activity	41/2244	230/18367	0.00813421073829255	0.0789666299106808	ITIH5/SPINT1/FBLN1/CRIM1/SERPINF1/SERPINH1/SPINT2/PEBP1/TIMP3/PCOLCE2/APP/CST3/PRDX5/SERPINA1/PYCARD/CARD16/CSTA/BAD/PSMD14/BST2/BIRC5/USP14/GPC3/TIMP1/ANXA2/CAV1/CASP1/PSME2/ADRM1/PRDX3/PSME1/VCP/SERPINB1/PTTG1/TNFAIP8/CTSH/NAIP/TIMP2/CTSC/CSTB/RPS6KA1	41
GO:0003688	DNA replication origin binding	6/2244	16/18367	0.00890036852262795	0.0849017762549814	HSPD1/MCM5/MCM2/CDC45/CDC6/GRWD1	6
GO:0005092	GDP-dissociation inhibitor activity	6/2244	16/18367	0.00890036852262795	0.0849017762549814	CHML/ARHGDIB/GPSM2/RANBP1/EIF5/CCDC88A	6
GO:0016836	hydro-lyase activity	15/2244	64/18367	0.00902545134996174	0.0853527597492071	HACD3/ECHDC2/ECHS1/ECI1/CA8/ENOSF1/FASN/FH/ALAD/PCBD1/PARK7/TBXAS1/HACD4/HADHB/CYP1B1	15
GO:0061631	ubiquitin conjugating enzyme activity	10/2244	36/18367	0.00919541593496885	0.0862168485526566	UBE2T/AKTIP/UBE2H/UBE2C/UBE2L6/UBE2N/CDC34/UBE2S/UBE2D3/UBE2L3	10
GO:0090482	vitamin transmembrane transporter activity	9/2244	31/18367	0.00975419845644593	0.0906809805654338	SLC2A1/SLC19A3/SLC52A3/SLC19A1/SLC5A6/SLC52A1/SLC2A8/SLC2A3/SLC52A2	9
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5/2244	12/18367	0.0102234699382879	0.0938210258845785	CDK6/CDK7/BRD4/CDK4/CDK1	5
GO:0019205	nucleobase-containing compound kinase activity	11/2244	42/18367	0.0102842753674612	0.0938210258845785	AK3/N4BP2/NME4/MPP1/DTYMK/NME1/DLG1/TK1/AK6/ADK/AK2	11
GO:0140297	DNA-binding transcription factor binding	64/2244	394/18367	0.010374597066934	0.0938210258845785	ISL1/RBFOX2/TACC2/PARP1/CENPF/FOS/ACTB/GMNN/YAP1/TBX3/PPARG/BHLHE41/KLF5/RPS3/FOXO4/FHL2/HMGA1/NPM1/TRIP6/CBX5/SPI1/NFKBIA/WFS1/HMGN3/CALR/PCNA/CEBPB/CREM/STAT1/TEAD3/MTDH/PURA/TRIM24/NFYB/FUS/HMGB1/CDKN2A/GABARAPL1/COMMD7/NCOA3/SMARCE1/BCL2/TAF11/MED16/CTNNB1/TDG/KLF4/GTF2A2/PSMC5/EXOSC9/PARK7/CHCHD2/HSPB1/LMO2/CPNE1/MEF2C/PARP9/HCLS1/MKKS/NR4A1/JUN/APEX1/NLRP3/PHB2	64
GO:0045182	translation regulator activity	27/2244	140/18367	0.0104939351332578	0.0938210258845785	IGF2BP3/EIF1AY/PABPC1/EIF1/TYMS/RPS9/TSFM/RPS14/DHFR/CIRBP/PURA/EIF2AK1/ABCF1/EIF5B/EIF3J/RPL22/AGO2/EIF2S2/ETF1/EEF1A1/EIF2AK4/TUFM/EIF5/EIF4A1/DENR/EIF3L/EIF4EBP1	27
GO:0031491	nucleosome binding	16/2244	71/18367	0.0105195863115799	0.0938210258845785	ACTB/SMARCA1/HMGN1/HMGN3/ACTL6A/PARP2/SSRP1/VRK1/ACTR6/EED/SMARCE1/NAP1L4/MBD3/SUPT16H/SMARCC1/HMGN2	16
GO:0002020	protease binding	26/2244	135/18367	0.0120714207950833	0.106470861533112	DPP4/TIMP3/ADAMTSL4/CST3/ITGAV/SERPINA1/PSAP/PYCARD/CARD16/ITGB1/CSTA/DVL3/BRCA2/TIMP1/ANXA2/SELL/ADRM1/BCL2/VCP/PARK7/TIMP2/TNF/RAD23A/CSTB/TNFAIP3/CLTC	26
GO:0030515	snoRNA binding	9/2244	32/18367	0.0121320489440648	0.106470861533112	NUDT4/PRKDC/GAR1/NHP2/NOP58/NOP56/SNU13/IMP3/NUDT5	9
GO:0070064	proline-rich region binding	6/2244	17/18367	0.0123558120372183	0.107574014324035	YAP1/CCND1/ABI2/BAIAP2/NEDD4/CSK	6
GO:0048027	mRNA 5'-UTR binding	8/2244	27/18367	0.012789397507589	0.108542611882408	MYH10/IGF2BP3/RPL5/RPS7/RPS14/NCL/DHX36/CCT5	8
GO:0008093	cytoskeletal anchor activity	7/2244	22/18367	0.0129946655363039	0.108542611882408	OBSL1/ANK3/ABI2/BAIAP2/NCK2/JUP/SDCBP	7
GO:0070182	DNA polymerase binding	7/2244	22/18367	0.0129946655363039	0.108542611882408	HSP90AB1/RAD51/HSP90AA1/CDT1/PCNA/FANCI/HMGB1	7
GO:0008047	enzyme activator activity	22/2244	110/18367	0.0130288495000388	0.108542611882408	GNAS/MMP15/GMFG/NCF1/DDOST/PSAP/NCF2/ARL1/PDCD5/PDPK1/EED/CYB5B/RFC1/CCL3/PARK7/SAE1/NUPR1/SUZ12/AZIN1/DPM2/FYN/NCF4	22
GO:0047485	protein N-terminus binding	22/2244	110/18367	0.0130288495000388	0.108542611882408	PARP1/RPS21/ID1/MYO7A/NPM1/PELP1/ZWINT/NCOA3/GLRX/SMARCE1/TAF11/MNAT1/RPA2/GTF2H3/VPS25/MORF4L1/SMARCC1/MDM2/SDCBP/NFE2/PHB2/HSPA1A	22
GO:0016763	pentosyltransferase activity	12/2244	49/18367	0.0130607336084575	0.108542611882408	QPRT/PARP1/TYMP/PNP/UMPS/MTAP/NAMPT/PARP2/GXYLT1/UPP1/PARP9/PARP14	12
GO:0019956	chemokine binding	9/2244	33/18367	0.0149160426065074	0.120712498817852	ITGAV/ITGB1/ZFP36/HMGB1/PLP2/CXCR4/ITGA4/CCR1/CCR2	9
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5/2244	13/18367	0.0149652687686672	0.120712498817852	DUSP9/DUSP1/DUSP14/DUSP5/DUSP6	5
GO:0031386	protein tag	5/2244	13/18367	0.0149652687686672	0.120712498817852	RPS27A/ISG15/UBB/NEDD8/UBL5	5
GO:0031994	insulin-like growth factor I binding	5/2244	13/18367	0.0149652687686672	0.120712498817852	LRP2/ITGB4/ITGA6/ITGAV/IGF1R	5
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	10/2244	39/18367	0.016385498468133	0.129315768485913	FERMT2/PHLDA3/PARD3/CYTH3/COMMD1/MYO1G/IQGAP1/DAPP1/IQGAP2/ARHGAP9	10
GO:0016776	phosphotransferase activity, phosphate group as acceptor	10/2244	39/18367	0.016385498468133	0.129315768485913	AK3/NME4/MPP1/DTYMK/PMVK/NME1/DLG1/IP6K2/AK6/AK2	10
GO:0061650	ubiquitin-like protein conjugating enzyme activity	10/2244	39/18367	0.016385498468133	0.129315768485913	UBE2T/AKTIP/UBE2H/UBE2C/UBE2L6/UBE2N/CDC34/UBE2S/UBE2D3/UBE2L3	10
GO:0019955	cytokine binding	26/2244	139/18367	0.0172938832734119	0.135509928220949	NRP2/TGFBR3/LTBP1/ITGAV/NRP1/CD74/PRLR/TSKU/ITGB1/ZFP36/CSF2RA/LTBP3/IL6ST/TNFRSF1B/HMGB1/CD36/PLP2/CXCR4/ITGA4/PARK7/GBP1/TNFRSF14/IL10RA/CCR1/CCR2/CD4	26
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	10/2244	40/18367	0.019520572569605	0.151872823467069	PRDX5/PYCARD/BAD/BIRC5/CASP1/PRDX3/TNFAIP8/CTSH/NAIP/RPS6KA1	10
GO:0051787	misfolded protein binding	8/2244	29/18367	0.0198276929840989	0.153175909884201	HSPA5/HSPA2/SDF2/HSPA14/DNAJB9/HSPA8/HSPA9/HSPA1A	8
GO:0004857	enzyme inhibitor activity	15/2244	70/18367	0.020309086890058	0.155797680548207	TXNIP/ANXA3/OAZ1/RPL5/ANXA5/RPS7/ANXA2/DFFA/RPL37/LRRK2/RPL23/PRPSAP1/RPS15/GCHFR/PARP9	15
GO:0051117	ATPase binding	18/2244	89/18367	0.0208235385985841	0.157629835291198	EGFR/SVIP/PELP1/WFS1/ABCA1/UBE4B/TOR1AIP2/CAV1/NOP58/SNX10/RDX/RALA/RUVBL1/SNU13/RUVBL2/EZR/GABARAPL2/PIH1D1	18
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	5/2244	14/18367	0.0209789935756745	0.157629835291198	ECI1/MIF/ECI2/ECH1/DDT	5
GO:0044548	S100 protein binding	5/2244	14/18367	0.0209789935756745	0.157629835291198	S100A6/ANXA2/EZR/IQGAP1/CACYBP	5
GO:0019887	protein kinase regulator activity	35/2244	204/18367	0.0234703612263799	0.175149566430876	CD24/CDKN1C/PKIB/ERBB3/GMFG/HSP90AB1/CCND1/NPM1/CCNE1/CKS1B/PARVA/TPX2/CCNB2/CDK4/IGF2/CCNB1/HEXIM1/HMGB1/RAC2/CDKN2A/CKS2/DAZAP2/CCNG1/MNAT1/RPLP1/MOB1A/HSPB1/SOCS3/CCNC/CCND3/NCKAP1L/IQGAP1/PAK2/STK4/CCNL1	35
GO:0140677	molecular function activator activity	27/2244	150/18367	0.0246825796079266	0.179754252137169	GNAS/MMP15/GMFG/NCF1/DDOST/PSAP/DNAJB4/NCF2/ARL1/PDCD5/TOR1AIP2/PDPK1/EED/DNAJC19/CYB5B/RFC1/CCL3/AHSA1/PARK7/SAE1/NUPR1/SUZ12/AZIN1/DPM2/DNAJB6/FYN/NCF4	27
GO:0001094	TFIID-class transcription factor complex binding	4/2244	10/18367	0.0253982762819153	0.179754252137169	NOP58/RUVBL1/RUVBL2/EDF1	4
GO:0004300	enoyl-CoA hydratase activity	4/2244	10/18367	0.0253982762819153	0.179754252137169	ECHDC2/ECHS1/ECI1/HADHB	4
GO:0005522	profilin binding	4/2244	10/18367	0.0253982762819153	0.179754252137169	CTTN/ENAH/VASP/WIPF1	4
GO:0005528	FK506 binding	4/2244	10/18367	0.0253982762819153	0.179754252137169	FKBP3/FKBP2/FKBP4/FKBP5	4
GO:0008330	protein tyrosine/threonine phosphatase activity	4/2244	10/18367	0.0253982762819153	0.179754252137169	DUSP9/DUSP1/DUSP5/DUSP6	4
GO:0016175	superoxide-generating NAD(P)H oxidase activity	4/2244	10/18367	0.0253982762819153	0.179754252137169	CYBA/CYBB/NCF1/NCF2	4
GO:0045294	alpha-catenin binding	4/2244	10/18367	0.0253982762819153	0.179754252137169	PKP3/PKP2/JUP/CTNNB1	4
GO:0030276	clathrin binding	15/2244	72/18367	0.0257995833333317	0.181423993055544	SYT7/EPN2/AP1M2/NSG1/AP1S3/STON1/AP1S2/DAB2/CLTA/AP1S1/LRRK2/AP2A2/AP2M1/CLTB/CLTC	15
GO:0000217	DNA secondary structure binding	9/2244	36/18367	0.0260658853775347	0.181693270395423	RAD51AP1/HMGA1/XRCC2/CLSPN/HMGB3/RAD51C/MSH6/HMGB1/MEF2C	9
GO:0140375	immune receptor activity	26/2244	144/18367	0.0261691310141083	0.181693270395423	FCER1G/CD74/PRLR/HLA-DRA/CSF2RA/HLA-DPA1/IL6ST/HLA-DRB1/CD44/FPR1/LILRB2/IFNGR2/IL10RB/C5AR1/CXCR4/LILRB3/HLA-DQB1/IL10RA/CTSH/CCR1/LILRB1/LILRA5/CCR2/CD4/IL17RA/HLA-DQA2	26
GO:0004714	transmembrane receptor protein tyrosine kinase activity	23/2244	124/18367	0.026344174966866	0.181758238607875	MET/EGFR/NRP2/EFEMP1/CRIM1/EPHB4/WEE1/ERBB3/NRP1/FLT1/IGF1R/YES1/PTK2/LYN/FGR/PBK/HCK/JAK2/BAZ1B/SYK/JAK1/FYN/CSK	23
GO:0050998	nitric-oxide synthase binding	5/2244	15/18367	0.0283710943851422	0.194519315878132	SLC6A4/ACTB/CD74/DMD/CAV1	5
GO:0140318	protein transporter activity	8/2244	31/18367	0.0292534232064367	0.199323014021498	LRP2/IGF1R/MCL1/ABCA1/TOMM40/TIMM8B/TIMM17A/TOMM20	8
GO:0003727	single-stranded RNA binding	17/2244	87/18367	0.0328786337917329	0.222641118947722	L1TD1/MSI2/RBPMS/RBMS3/PABPC1/CBX4/ZC3H14/HMGB1/DDX1/HNRNPA1/AGO2/POLR2G/HNRNPDL/LSM14A/SNRPC/PTBP1/TLR8	17
GO:0019838	growth factor binding	25/2244	141/18367	0.0350440087506619	0.233843715930938	LRP2/ITGB4/EGFR/NRP2/ITGA6/CRIM1/TGFBR3/LTBP1/DUSP1/ERBB3/ITGAV/NRP1/PTN/GPC1/FLT1/COL4A1/TSKU/S100A13/IGF1R/LTBP3/RPS19/IL6ST/CD36/IL10RA/SDCBP	25
GO:0051287	NAD binding	12/2244	56/18367	0.0355800141931062	0.233843715930938	PARP1/ALDH1A3/IDH2/IDH1/HPGD/UXS1/NDUFV1/HIBADH/ALDH2/MDH1/GRHPR/AHCY	12
GO:0000774	adenyl-nucleotide exchange factor activity	4/2244	11/18367	0.0361269572988866	0.233843715930938	BAG2/SIL1/GRPEL1/BAG1	4
GO:0008199	ferric iron binding	4/2244	11/18367	0.0361269572988866	0.233843715930938	FTL/FTH1/RRM2/FXN	4
GO:0019864	IgG binding	4/2244	11/18367	0.0361269572988866	0.233843715930938	FCER1G/FCGRT/FCGR2A/FCGR1A	4
GO:0043560	insulin receptor substrate binding	4/2244	11/18367	0.0361269572988866	0.233843715930938	IGF1R/PRKCZ/JAK2/PTPN11	4
GO:0097493	structural molecule activity conferring elasticity	4/2244	11/18367	0.0361269572988866	0.233843715930938	FBN1/FBN2/LAMC1/EMILIN2	4
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	11/2244	50/18367	0.0362383151397078	0.233843715930938	TLR3/UNG/PCNA/OARD1/TDG/DNPH1/PIK3AP1/BST1/TLR2/APEX1/TLR8	11
GO:0017070	U6 snRNA binding	5/2244	16/18367	0.0372214243226487	0.234666106218078	LSM3/LSM2/LSM7/LSM4/LSM8	5
GO:0032183	SUMO binding	5/2244	16/18367	0.0372214243226487	0.234666106218078	PELP1/CBX4/TDG/UBA2/SERBP1	5
GO:0035173	histone kinase activity	5/2244	16/18367	0.0372214243226487	0.234666106218078	CHEK1/VRK1/CDK1/JAK2/BAZ1B	5
GO:1990380	Lys48-specific deubiquitinase activity	5/2244	16/18367	0.0372214243226487	0.234666106218078	USP27X/OTUD7B/USP15/DESI2/USP9X	5
GO:0031072	heat shock protein binding	23/2244	129/18367	0.0395999727449577	0.248235257721249	BAG2/ITGB2/DNAJC9/RPS3/HSP90AB1/ZFP36/TOMM34/TFAM/HSPA5/ST13/HSPA2/HSPA14/AHSA1/DNAJB9/GBP1/FKBP4/HSPA8/HSPA9/DNAJB6/ITGAM/FKBP5/HSPA1A/BAG1	23
GO:0019199	transmembrane receptor protein kinase activity	25/2244	143/18367	0.0406567341107655	0.253411575679033	MET/EGFR/NRP2/EFEMP1/CRIM1/TGFBR3/LTBP1/EPHB4/WEE1/ERBB3/NRP1/FLT1/IGF1R/YES1/PTK2/LYN/FGR/PBK/HCK/JAK2/BAZ1B/SYK/JAK1/FYN/CSK	25
GO:0005154	epidermal growth factor receptor binding	8/2244	33/18367	0.041374789673858	0.256430193628374	EFEMP1/FAM83B/YES1/VAV3/SNX4/ARF4/PLSCR1/CCDC88A	8
GO:0008514	organic anion transmembrane transporter activity	31/2244	185/18367	0.0417235745669091	0.257139108426401	SLC26A2/GJA1/SLC2A1/SLC22A11/SLC38A1/SLC16A12/SLC35B4/SLC52A3/SLC13A3/SLC19A1/SLC16A1/MPC2/SLC25A4/SLC38A9/SLC5A6/SLC52A1/SLC1A3/SLC7A2/SLC29A1/SLC2A8/SLC25A5/SLC2A3/SFXN1/SLC1A5/CD36/SLC52A2/SLC25A13/SLC3A2/SLC25A1/SLC16A3/SLC25A6	31
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	6/2244	22/18367	0.0437960128221314	0.266912367032656	PRDX5/BIRC5/PRDX3/TNFAIP8/NAIP/RPS6KA1	6
GO:0055106	ubiquitin-protein transferase regulator activity	6/2244	22/18367	0.0437960128221314	0.266912367032656	RPL5/RPS7/RPL37/RPL23/RPS15/UBE2L3	6
GO:0038024	cargo receptor activity	15/2244	77/18367	0.0442526041881487	0.268205009913807	LRP2/COLEC12/FOLR1/ITGB2/SCARA3/TFRC/PRSS12/LGALS3BP/DAB2/ABCA1/CD36/ASGR1/ITGAM/CD163/SORL1	15
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	22/2244	124/18367	0.0454976515998365	0.274235845082531	HSD17B1/LDHB/DCXR/AKR1B1/ADH5/IDH2/GCLM/DHRS3/FASN/IMPDH2/IDH1/HPGD/HIBADH/RDH14/KDSR/MDH1/DHRS7B/AKR7A2/GRHPR/MDH2/HSD17B11/HADHB	22
GO:0001540	amyloid-beta binding	16/2244	84/18367	0.0462968399541702	0.276099153713677	CST3/ITM2C/ITGB2/CD74/LRPAP1/PFDN5/PFDN1/LILRB2/CD36/PFDN4/CLSTN1/PFDN6/PFDN2/TLR2/ITGAM/SORL1	16
GO:0016830	carbon-carbon lyase activity	11/2244	52/18367	0.0468041447673566	0.276099153713677	PAICS/UMPS/UXS1/GGCX/PISD/GOT1/PDXDC1/UROD/ARMT1/AZIN1/DDT	11
GO:0001968	fibronectin binding	7/2244	28/18367	0.0471513183242567	0.276099153713677	CCDC80/FBLN1/CTSL/CTSS/ITGAV/ITGB1/ITGA4	7
GO:0000400	four-way junction DNA binding	5/2244	17/18367	0.0475820961082447	0.276099153713677	XRCC2/HMGB3/RAD51C/MSH6/HMGB1	5
GO:0032393	MHC class I receptor activity	5/2244	17/18367	0.0475820961082447	0.276099153713677	LILRB2/LILRB3/CTSH/LILRB1/LILRA5	5
GO:0043024	ribosomal small subunit binding	5/2244	17/18367	0.0475820961082447	0.276099153713677	NPM1/EIF1/UNG/NME1/ERAL1	5
GO:0016248	channel inhibitor activity	8/2244	34/18367	0.0485230541054765	0.276099153713677	RASA1/PACSIN3/NEDD4/CAV1/BCL2/COMMD1/PHPT1/ENSA	8
GO:0004177	aminopeptidase activity	9/2244	40/18367	0.0486482322448535	0.276099153713677	DPP4/ENPEP/CTSV/MMP15/MMP14/LAP3/METAP2/BLMH/CTSH	9
GO:0005527	macrolide binding	4/2244	12/18367	0.0490787009791859	0.276099153713677	FKBP3/FKBP2/FKBP4/FKBP5	4
GO:0017154	semaphorin receptor activity	4/2244	12/18367	0.0490787009791859	0.276099153713677	MET/NRP2/NRP1/PLXNC1	4
GO:0017166	vinculin binding	4/2244	12/18367	0.0490787009791859	0.276099153713677	DAG1/DMD/RTCB/ACTN1	4
GO:0032396	inhibitory MHC class I receptor activity	4/2244	12/18367	0.0490787009791859	0.276099153713677	LILRB2/LILRB3/LILRB1/LILRA5	4
GO:0061578	Lys63-specific deubiquitinase activity	4/2244	12/18367	0.0490787009791859	0.276099153713677	USP27X/PSMD14/DESI2/TNFAIP3	4
GO:0043130	ubiquitin binding	17/2244	92/18367	0.0524527524657883	0.293574844158009	CKS1B/N4BP2/NEDD4/TOP2A/UBXN2A/UBE2L6/CKS2/ADRM1/TSG101/UBE2N/CXCR4/RAD23B/UCHL3/HSPB1/MDM2/RAD23A/TNFAIP3	17
GO:0017069	snRNA binding	11/2244	53/18367	0.0528006690904844	0.294021999960717	LSM3/LSM2/LSM7/HEXIM1/SNRPA1/SNRPD3/SNU13/SNRNP70/COIL/LSM4/LSM8	11
GO:0008143	poly(A) binding	6/2244	23/18367	0.0533408601259228	0.29552991696029	RBPMS/RBMS3/PABPC1/ZC3H14/DDX1/HNRNPDL	6
GO:0048487	beta-tubulin binding	9/2244	41/18367	0.0558413433231923	0.303278135784132	PDCD5/TBCA/RGS2/SMC3/GABARAPL1/LRPPRC/EML4/GABARAPL2/CCT5	9
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	7/2244	29/18367	0.0558451991143069	0.303278135784132	PHLDA3/NCF1/PLEKHA1/PLEK/COMMD1/MYO1G/DAPP1	7
GO:0046625	sphingolipid binding	7/2244	29/18367	0.0558451991143069	0.303278135784132	PSAP/LYN/VDAC1/PLEKHA8/SELL/VDAC2/PHB2	7
GO:0051059	NF-kappaB binding	7/2244	29/18367	0.0558451991143069	0.303278135784132	NPM1/NFKBIA/MTDH/CDKN2A/COMMD7/CPNE1/APEX1	7
GO:0019207	kinase regulator activity	37/2244	233/18367	0.0567155607251311	0.305080074838349	CD24/CDKN1C/PKIB/ERBB3/GMFG/HSP90AB1/GSTP1/CCND1/NPM1/CCNE1/CKS1B/PARVA/TPX2/CCNB2/CDK4/IGF2/CCNB1/HEXIM1/HMGB1/RAC2/CDKN2A/CKS2/DAZAP2/CCNG1/MNAT1/KLF4/RPLP1/MOB1A/HSPB1/SOCS3/CCNC/CCND3/NCKAP1L/IQGAP1/PAK2/STK4/CCNL1	37
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	12/2244	60/18367	0.0567332135524368	0.305080074838349	DHCR24/AKR1B1/TECR/ACADVL/FASN/TM7SF2/ACADS/BLVRB/DPYD/PTGES2/TBXAS1/BLVRA	12
GO:0072341	modified amino acid binding	17/2244	93/18367	0.0571787046309249	0.305975799903047	MME/SYT7/FOLR1/SCIN/SLC19A1/PTGES/TYMS/FASN/DHFR/ANXA2/HMGB1/PTGES2/HSPA8/CPNE1/MGST1/CD300A/OSBPL8	17
GO:0000295	adenine nucleotide transmembrane transporter activity	5/2244	18/18367	0.0594775197650947	0.312185833408176	SLC19A1/SLC25A4/SLC29A1/SLC25A5/SLC25A6	5
GO:0005346	purine ribonucleotide transmembrane transporter activity	5/2244	18/18367	0.0594775197650947	0.312185833408176	SLC19A1/SLC25A4/SLC29A1/SLC25A5/SLC25A6	5
GO:0008301	DNA binding, bending	5/2244	18/18367	0.0594775197650947	0.312185833408176	HMGB3/FOXC1/TFAM/TOP2A/HMGB1	5
GO:0033549	MAP kinase phosphatase activity	5/2244	18/18367	0.0594775197650947	0.312185833408176	DUSP9/DUSP1/DUSP14/DUSP5/DUSP6	5
GO:0015026	coreceptor activity	10/2244	48/18367	0.0616638509929435	0.319996786120186	TGFBR3/LRP5/ITGAV/NRP1/ITGB1/CXCR4/ITGA4/LY96/CD86/CD4	10
GO:0001965	G-protein alpha-subunit binding	6/2244	24/18367	0.0640490969866641	0.319996786120186	GPSM2/RGS2/NUCB2/RGS10/RGS19/CCDC88A	6
GO:0043274	phospholipase binding	6/2244	24/18367	0.0640490969866641	0.319996786120186	PRKCZ/WAS/PDPK1/SYK/PTPN11/FYN	6
GO:0050431	transforming growth factor beta binding	6/2244	24/18367	0.0640490969866641	0.319996786120186	TGFBR3/LTBP1/ITGAV/TSKU/LTBP3/CD36	6
GO:0090079	translation regulator activity, nucleic acid binding	19/2244	108/18367	0.0641573795051303	0.319996786120186	EIF1AY/PABPC1/EIF1/TYMS/TSFM/DHFR/PURA/ABCF1/EIF5B/EIF3J/AGO2/EIF2S2/ETF1/EEF1A1/TUFM/EIF5/EIF4A1/DENR/EIF3L	19
GO:0005542	folic acid binding	4/2244	13/18367	0.0642402264060832	0.319996786120186	FOLR1/SLC19A1/TYMS/DHFR	4
GO:0019104	DNA N-glycosylase activity	4/2244	13/18367	0.0642402264060832	0.319996786120186	UNG/PCNA/TDG/APEX1	4
GO:0060590	ATPase regulator activity	4/2244	13/18367	0.0642402264060832	0.319996786120186	BAG2/SIL1/GRPEL1/BAG1	4
GO:0061133	endopeptidase activator activity	4/2244	13/18367	0.0642402264060832	0.319996786120186	PSMD14/PSME2/ADRM1/PSME1	4
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	4/2244	13/18367	0.0642402264060832	0.319996786120186	CKS1B/CCNB1/CKS2/MNAT1	4
GO:0035591	signaling adaptor activity	15/2244	81/18367	0.0645764741246461	0.319996786120186	DLG5/HOMER1/ABI2/SORBS1/EPS8/NCK2/MPP7/LRRK2/DOK2/CRK/PTPN11/IQGAP1/SPAG9/AKAP13/PAG1	15
GO:0016887	ATP hydrolysis activity	42/2244	272/18367	0.0648857366031115	0.319996786120186	RHOBTB3/MCM3/MCM4/MCM7/HSPD1/MCM5/NAV2/HSP90AA1/MCM6/MCM2/ATP10D/ATAD2/HSPA5/KIF21A/DDX3Y/CHD7/MOV10/ATP2B1/G3BP1/HSPA2/RNF213/KIF20B/HSPA14/DDX1/ATP13A3/RUVBL1/RUVBL2/DDX56/VCP/DHX32/HSPA8/HSPA9/EIF4A1/DDX24/DDX18/DHX36/OLA1/DDX52/KIF22/DDX46/HSPA1A/SMCHD1	42
GO:0042162	telomeric DNA binding	8/2244	36/18367	0.0651012112995869	0.319996786120186	PURA/RAD50/HNRNPA1/RPA2/NCL/UPF3A/XRCC6/APEX1	8
GO:0043394	proteoglycan binding	8/2244	36/18367	0.0651012112995869	0.319996786120186	CTSL/CTSS/PTPRF/PTPRC/PTN/CTSB/SDCBP/HPSE	8
GO:0004713	protein tyrosine kinase activity	23/2244	136/18367	0.0656328868523626	0.319996786120186	MET/EGFR/NRP2/EFEMP1/CRIM1/EPHB4/WEE1/ERBB3/NRP1/FLT1/IGF1R/YES1/PTK2/LYN/FGR/PBK/HCK/JAK2/BAZ1B/SYK/JAK1/FYN/CSK	23
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	23/2244	136/18367	0.0656328868523626	0.319996786120186	HSD17B1/LDHB/DCXR/AKR1B1/ADH5/IDH2/GCLM/DHRS3/FASN/IMPDH2/IDH1/HPGD/HIBADH/RDH14/KDSR/MDH1/D2HGDH/DHRS7B/AKR7A2/GRHPR/MDH2/HSD17B11/HADHB	23
GO:0061135	endopeptidase regulator activity	31/2244	194/18367	0.0708332597815734	0.343823389293743	ITIH5/SPINT1/CRIM1/SERPINF1/SERPINH1/SPINT2/PEBP1/TIMP3/APP/CST3/PRDX5/SERPINA1/CARD16/CSTA/PSMD14/BST2/BIRC5/USP14/TIMP1/ANXA2/PSME2/ADRM1/PRDX3/PSME1/SERPINB1/PTTG1/TNFAIP8/NAIP/TIMP2/CSTB/RPS6KA1	31
GO:0010314	phosphatidylinositol-5-phosphate binding	5/2244	19/18367	0.0729054019852754	0.352322581400208	PHLDA3/PLEKHF1/PLEKHA5/SNX24/SNX3	5
GO:0004869	cysteine-type endopeptidase inhibitor activity	11/2244	56/18367	0.0737896819294547	0.354071551796179	CST3/PRDX5/CARD16/CSTA/BIRC5/PRDX3/PTTG1/TNFAIP8/NAIP/CSTB/RPS6KA1	11
GO:0008238	exopeptidase activity	18/2244	103/18367	0.0739128398918186	0.354071551796179	DPP4/MME/ENPEP/CTSV/GGH/TFRC/MMP15/MMP14/CTSZ/LAP3/METAP2/BLMH/SCRN2/CTSH/CPVL/SCPEP1/CTSC/TPP1	18
GO:0008327	methyl-CpG binding	6/2244	25/18367	0.0759249816964882	0.361074306543135	DNMT1/PRMT1/WDR77/ERH/ZBTB38/MBD3	6
GO:0005164	tumor necrosis factor receptor binding	7/2244	31/18367	0.076032967011362	0.361074306543135	TNFSF10/TRAF4/TNFSF13B/TRAP1/STAT1/SIVA1/TNF	7
GO:0140030	modification-dependent protein binding	26/2244	160/18367	0.0783721205390002	0.37057851823829	MORC4/AGL/LAPTM5/HSPD1/OTUD7B/CBX5/BRD4/CBX4/NCAPD3/LYN/YEATS4/SPIN1/TRIM24/BRD7/USP15/MSH6/OPTN/PTPN6/ING2/RAD23B/VCP/SUZ12/PWP1/RAD23A/PSMD4/TNFAIP3	26
GO:0005172	vascular endothelial growth factor receptor binding	4/2244	14/18367	0.0815447195382468	0.380657690780667	CD2AP/VEGFB/CCDC88A/ITGA5	4
GO:0008474	palmitoyl-(protein) hydrolase activity	4/2244	14/18367	0.0815447195382468	0.380657690780667	ABHD12/LYPLAL1/PPT1/LYPLA1	4
GO:0098599	palmitoyl hydrolase activity	4/2244	14/18367	0.0815447195382468	0.380657690780667	ABHD12/LYPLAL1/PPT1/LYPLA1	4
GO:0008135	translation factor activity, RNA binding	15/2244	84/18367	0.0833972363124759	0.387655797605026	EIF1AY/EIF1/TSFM/ABCF1/EIF5B/EIF3J/AGO2/EIF2S2/ETF1/EEF1A1/TUFM/EIF5/EIF4A1/DENR/EIF3L	15
GO:0008234	cysteine-type peptidase activity	30/2244	190/18367	0.0841418400194129	0.389466660343021	CTSL/CTSS/CTSV/USP27X/GGH/LGMN/PYCARD/OTUD7B/GPAA1/PSMD14/USP14/CTSZ/PDIA3/USP22/USP15/CASP1/DESI2/BLMH/SCRN2/CAPN1/CTSB/UCHL3/CTSD/CTSH/USP10/USP48/CTSC/USP3/USP9X/TNFAIP3	30
GO:0004197	cysteine-type endopeptidase activity	20/2244	119/18367	0.0858454239388556	0.391702548537965	CTSL/CTSS/CTSV/LGMN/PYCARD/GPAA1/USP14/CTSZ/PDIA3/USP15/CASP1/BLMH/CAPN1/CTSB/CTSD/CTSH/USP10/USP48/CTSC/USP9X	20
GO:0003743	translation initiation factor activity	10/2244	51/18367	0.0865113481717323	0.391702548537965	EIF1AY/EIF1/EIF5B/EIF3J/AGO2/EIF2S2/EIF5/EIF4A1/DENR/EIF3L	10
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	5/2244	20/18367	0.0878384931087871	0.391702548537965	FOS/CEBPB/EZH2/STAT1/RUVBL2	5
GO:0003756	protein disulfide isomerase activity	5/2244	20/18367	0.0878384931087871	0.391702548537965	P4HB/PDIA6/PDIA3/PDIA4/PDIA5	5
GO:0016505	peptidase activator activity involved in apoptotic process	5/2244	20/18367	0.0878384931087871	0.391702548537965	PYCARD/BAD/CASP1/CTSH/CTSC	5
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	5/2244	20/18367	0.0878384931087871	0.391702548537965	P4HB/PDIA6/PDIA3/PDIA4/PDIA5	5
GO:0031683	G-protein beta/gamma-subunit complex binding	5/2244	20/18367	0.0878384931087871	0.391702548537965	GNAS/GNA12/GNAI1/GNAI2/GNA11	5
GO:0031690	adrenergic receptor binding	5/2244	20/18367	0.0878384931087871	0.391702548537965	ADRB1/GNAS/C1QBP/NEDD4/ARRB2	5
GO:0050145	nucleoside monophosphate kinase activity	5/2244	20/18367	0.0878384931087871	0.391702548537965	MPP1/DTYMK/DLG1/AK6/AK2	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	11/2244	58/18367	0.0903557438942489	0.401296562963526	SMS/PTGES/GSTP1/GSTA4/FDPS/SRM/MMAB/GSTZ1/FDFT1/FNTA/MGST1	11
GO:0048156	tau protein binding	9/2244	45/18367	0.0912330324372518	0.402584188991879	BAG2/ACTB/LGMN/HSP90AB1/HSP90AA1/HSPA2/FKBP4/PPP2CB/FYN	9
GO:0042826	histone deacetylase binding	21/2244	127/18367	0.0913796381576826	0.402584188991879	PARP1/GMNN/GLI3/BEX4/BHLHE41/HSP90AB1/CCND1/MAGEA10/HSP90AA1/MTA3/SPI1/CEBPB/TOP2A/PHB/YWHAE/KPNA2/KLF4/MEF2C/DHX36/SFPQ/HSPA1A	21
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	8/2244	39/18367	0.095813937694841	0.420431558604962	POLR2L/POLR2I/POLR2H/POLR2F/POLR2K/POLR2G/POLR3K/POLR2J	8
GO:0008200	ion channel inhibitor activity	7/2244	33/18367	0.0999605206033594	0.42893798373497	RASA1/PACSIN3/NEDD4/CAV1/COMMD1/PHPT1/ENSA	7
GO:0051427	hormone receptor binding	7/2244	33/18367	0.0999605206033594	0.42893798373497	GNAS/JAK2/PSMC5/PTPN11/JAK1/CSH1/FYN	7
GO:0004029	aldehyde dehydrogenase (NAD+) activity	4/2244	15/18367	0.100880583230285	0.42893798373497	ALDH7A1/ALDH1A3/ADH5/ALDH2	4
GO:0032794	GTPase activating protein binding	4/2244	15/18367	0.100880583230285	0.42893798373497	CDH1/GNAI1/TUBB/FMNL1	4
GO:0043138	3'-5' DNA helicase activity	4/2244	15/18367	0.100880583230285	0.42893798373497	MCM5/NAV2/MCM6/MCM2	4
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	4/2244	15/18367	0.100880583230285	0.42893798373497	CYBA/CYBB/NCF1/NCF2	4
GO:1904680	peptide transmembrane transporter activity	4/2244	15/18367	0.100880583230285	0.42893798373497	GJA1/SLC13A3/TAPBP/TAP1	4
GO:1990825	sequence-specific mRNA binding	4/2244	15/18367	0.100880583230285	0.42893798373497	TYMS/DHFR/ETF1/SRSF4	4
GO:0015215	nucleotide transmembrane transporter activity	6/2244	27/18367	0.10312629208578	0.4330942828681	SLC19A1/SLC25A4/SLC29A1/SLC25A36/SLC25A5/SLC25A6	6
GO:0022884	macromolecule transmembrane transporter activity	6/2244	27/18367	0.10312629208578	0.4330942828681	MCL1/ABCA1/TOMM40/HNRNPA3/TIMM17A/TOMM20	6
GO:0070063	RNA polymerase binding	13/2244	73/18367	0.103623022091624	0.4330942828681	SMYD2/ZFP36/BRD4/PPIB/NEDD4/STOM/RTF1/WDR43/ZNF326/NCOA3/AGO2/PABPN1/ANP32B	13
GO:0015216	purine nucleotide transmembrane transporter activity	5/2244	21/18367	0.104226883023864	0.4330942828681	SLC19A1/SLC25A4/SLC29A1/SLC25A5/SLC25A6	5
GO:0051428	peptide hormone receptor binding	5/2244	21/18367	0.104226883023864	0.4330942828681	GNAS/JAK2/PSMC5/PTPN11/FYN	5
GO:0140416	transcription regulator inhibitor activity	5/2244	21/18367	0.104226883023864	0.4330942828681	ID4/ID1/MDFI/ID3/PURA	5
GO:0031492	nucleosomal DNA binding	8/2244	40/18367	0.107605364057338	0.442965972316062	ACTB/HMGN1/HMGN3/ACTL6A/SMARCE1/MBD3/SMARCC1/HMGN2	8
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	44/2244	299/18367	0.109179399340793	0.442965972316062	ISL1/TACC2/PARP1/FOS/ACTB/TBX3/PPARG/BHLHE41/HMGA1/NPM1/TRIP6/SPI1/NFKBIA/HMGN3/CALR/PCNA/CEBPB/STAT1/TEAD3/MTDH/TRIM24/FUS/CDKN2A/GABARAPL1/COMMD7/NCOA3/SMARCE1/TAF11/MED16/CTNNB1/KLF4/GTF2A2/EXOSC9/PARK7/HSPB1/LMO2/CPNE1/PARP9/HCLS1/MKKS/NR4A1/JUN/APEX1/PHB2	44
GO:0008509	anion transmembrane transporter activity	46/2244	314/18367	0.109211949249173	0.442965972316062	SLC26A2/GJA1/CLDN4/SLC2A1/GABRE/SLC22A11/SLC38A1/FXYD3/SLC13A4/SLC6A4/SLC16A12/SLC35B4/SLC52A3/SLC13A3/SLC19A1/SLC16A1/MPC2/CLIC3/SLC25A4/SLC38A9/SLC5A6/SLC12A4/SLC52A1/SLC1A3/SLC7A2/SLC29A1/SLC9A1/SLC2A8/ANKH/SLC25A5/SLC2A3/VDAC1/SFXN1/SLC1A5/CD36/SLC52A2/SLC25A13/SLC12A9/VDAC2/VDAC3/SLC3A2/CLIC4/SLC25A1/SLC16A3/CLIC1/SLC25A6	46
GO:0004725	protein tyrosine phosphatase activity	17/2244	102/18367	0.113112008454909	0.442965972316062	DUSP9/PTPRF/PTPRC/DUSP1/DUSP14/PTPN14/DUSP5/UBASH3B/PGP/ACP1/PTP4A1/PTPN6/PTPN1/TIMM50/PTP4A2/PTPN11/DUSP6	17
GO:0004523	RNA-DNA hybrid ribonuclease activity	3/2244	10/18367	0.113281541533384	0.442965972316062	FEN1/RNASEH2A/APEX1	3
GO:0008097	5S rRNA binding	3/2244	10/18367	0.113281541533384	0.442965972316062	RPL5/RPF2/MDM2	3
GO:0008172	S-methyltransferase activity	3/2244	10/18367	0.113281541533384	0.442965972316062	DNMT3A/MTR/MGMT	3
GO:0008641	ubiquitin-like modifier activating enzyme activity	3/2244	10/18367	0.113281541533384	0.442965972316062	NAE1/SAE1/UBA2	3
GO:0016176	superoxide-generating NADPH oxidase activator activity	3/2244	10/18367	0.113281541533384	0.442965972316062	NCF1/NCF2/NCF4	3
GO:0016868	intramolecular transferase activity, phosphotransferases	3/2244	10/18367	0.113281541533384	0.442965972316062	PGM1/PMM2/PGM3	3
GO:0030957	Tat protein binding	3/2244	10/18367	0.113281541533384	0.442965972316062	ACTB/NPM1/GABARAPL1	3
GO:0043208	glycosphingolipid binding	3/2244	10/18367	0.113281541533384	0.442965972316062	PSAP/LYN/SELL	3
GO:0070008	serine-type exopeptidase activity	3/2244	10/18367	0.113281541533384	0.442965972316062	CPVL/SCPEP1/TPP1	3
GO:0070567	cytidylyltransferase activity	3/2244	10/18367	0.113281541533384	0.442965972316062	CDS1/PCYT2/CMAS	3
GO:0071723	lipopeptide binding	3/2244	10/18367	0.113281541533384	0.442965972316062	CD14/TLR2/CD1D	3
GO:0043548	phosphatidylinositol 3-kinase binding	7/2244	34/18367	0.113296160065773	0.442965972316062	CORO1A/IGF1R/FAM83B/HCST/JAK2/PIK3AP1/FYN	7
GO:0048306	calcium-dependent protein binding	15/2244	88/18367	0.113467126910495	0.442965972316062	S100A4/S100A6/ANXA3/S100A8/S100A9/S100A13/S100P/WFS1/CLN3/SLC9A1/S100A12/ANXA2/PEF1/TSG101/PDCD6	15
GO:0003785	actin monomer binding	6/2244	28/18367	0.118392194020741	0.454047566929428	TMSB4X/TMSB10/LIMA1/COBLL1/COBL/CORO1A	6
GO:0046875	ephrin receptor binding	6/2244	28/18367	0.118392194020741	0.454047566929428	EFNA1/LYN/PTPN1/CRK/SDCBP/FYN	6
GO:0005507	copper ion binding	11/2244	61/18367	0.119099102429685	0.454047566929428	F5/GPC1/SOD1/SOD3/S100A13/S100A12/SNCG/CUTA/COMMD1/PARK7/SCO2	11
GO:0019003	GDP binding	13/2244	75/18367	0.121567939990826	0.454047566929428	HRAS/GNAI1/RAN/RRAS2/RAB17/RHOA/RHEB/RALA/RHOB/RRAGC/GBP1/ARL2/RAB8B	13
GO:0008320	protein transmembrane transporter activity	5/2244	22/18367	0.122000668377314	0.454047566929428	MCL1/ABCA1/TOMM40/TIMM17A/TOMM20	5
GO:0030742	GTP-dependent protein binding	5/2244	22/18367	0.122000668377314	0.454047566929428	RAB38/RAB32/CDC42/GCHFR/EEA1	5
GO:0070034	telomerase RNA binding	5/2244	22/18367	0.122000668377314	0.454047566929428	GAR1/NHP2/SNRPD3/SNRPB/DHX36	5
GO:0072349	modified amino acid transmembrane transporter activity	5/2244	22/18367	0.122000668377314	0.454047566929428	GJA1/SLC16A12/SLC13A3/SLC19A1/SLC5A6	5
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	4/2244	16/18367	0.122100302866164	0.454047566929428	ALDH7A1/ALDH1A3/ADH5/ALDH2	4
GO:0004698	calcium-dependent protein kinase C activity	4/2244	16/18367	0.122100302866164	0.454047566929428	PRKCZ/PRKCH/PRKCI/CCL3	4
GO:0005159	insulin-like growth factor receptor binding	4/2244	16/18367	0.122100302866164	0.454047566929428	GNAS/IGF2/INSL4/CRK	4
GO:0008191	metalloendopeptidase inhibitor activity	4/2244	16/18367	0.122100302866164	0.454047566929428	TIMP3/BST2/TIMP1/TIMP2	4
GO:0070492	oligosaccharide binding	4/2244	16/18367	0.122100302866164	0.454047566929428	LGALS1/CHID1/SELL/LGALS9	4
GO:1990404	protein ADP-ribosylase activity	4/2244	16/18367	0.122100302866164	0.454047566929428	PARP1/PARP2/PARP9/PARP14	4
GO:1990841	promoter-specific chromatin binding	11/2244	62/18367	0.129702353722046	0.480687439300961	ISL1/DNMT1/FOXO4/FOXC1/TRIM28/EZH2/CHD7/STAT1/KLF4/E2F4/USP3	11
GO:0005518	collagen binding	12/2244	69/18367	0.1307531673926	0.48295025127839	COL14A1/ADGRG1/CTSL/SERPINH1/CTSS/PCOLCE2/ITGB1/C1QTNF1/CD44/PPIB/CTSB/TGFBI	12
GO:0001046	core promoter sequence-specific DNA binding	8/2244	42/18367	0.133440312497861	0.490948688113745	FOS/NPM1/CEBPB/EZH2/STAT1/AGO2/RUVBL2/PIH1D1	8
GO:0005520	insulin-like growth factor binding	6/2244	29/18367	0.134708801387636	0.490948688113745	LRP2/ITGB4/ITGA6/CRIM1/ITGAV/IGF1R	6
GO:0070273	phosphatidylinositol-4-phosphate binding	6/2244	29/18367	0.134708801387636	0.490948688113745	PLEKHF1/PLEKHA5/PLEKHA8/SNX24/SNX3/OSBPL8	6
GO:0070717	poly-purine tract binding	6/2244	29/18367	0.134708801387636	0.490948688113745	RBPMS/RBMS3/PABPC1/ZC3H14/DDX1/HNRNPDL	6
GO:0070851	growth factor receptor binding	22/2244	141/18367	0.135999639227502	0.492142959468735	EFEMP1/APP/GATA3/FAM83B/PYCARD/TRIP6/YES1/IL6ST/CD2AP/LYN/VAV3/SNX4/VEGFB/ARF4/TIMM50/JAK2/PLSCR1/IL1B/SDCBP/CCDC88A/FYN/ITGA5	22
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	5/2244	23/18367	0.141072837336034	0.492142959468735	CDO1/ADI1/PIR/ETHE1/ALOX5	5
GO:0017134	fibroblast growth factor binding	5/2244	23/18367	0.141072837336034	0.492142959468735	TGFBR3/ITGAV/GPC1/S100A13/RPS19	5
GO:0005078	MAP-kinase scaffold activity	3/2244	11/18367	0.142214510621321	0.492142959468735	IQGAP1/SPAG9/AKAP13	3
GO:0005347	ATP transmembrane transporter activity	3/2244	11/18367	0.142214510621321	0.492142959468735	SLC25A4/SLC25A5/SLC25A6	3
GO:0005536	glucose binding	3/2244	11/18367	0.142214510621321	0.492142959468735	UGP2/SLC2A8/SLC2A3	3
GO:0010485	H4 histone acetyltransferase activity	3/2244	11/18367	0.142214510621321	0.492142959468735	BRCA2/USP22/HAT1	3
GO:0016801	hydrolase activity, acting on ether bonds	3/2244	11/18367	0.142214510621321	0.492142959468735	EPHX2/AKR7A2/AHCY	3
GO:0043295	glutathione binding	3/2244	11/18367	0.142214510621321	0.492142959468735	PTGES/PTGES2/MGST1	3
GO:0043522	leucine zipper domain binding	3/2244	11/18367	0.142214510621321	0.492142959468735	PAWR/ERC1/PMF1	3
GO:0047429	nucleoside-triphosphate diphosphatase activity	3/2244	11/18367	0.142214510621321	0.492142959468735	DCTPP1/DUT/NUDT15	3
GO:0051400	BH domain binding	3/2244	11/18367	0.142214510621321	0.492142959468735	MCL1/BCL2A1/BCL2	3
GO:0061665	SUMO ligase activity	3/2244	11/18367	0.142214510621321	0.492142959468735	CBX4/KIAA1586/ZNF451	3
GO:0097371	MDM2/MDM4 family protein binding	3/2244	11/18367	0.142214510621321	0.492142959468735	TP63/RPL37/RPS15	3
GO:0099186	structural constituent of postsynapse	3/2244	11/18367	0.142214510621321	0.492142959468735	ACTB/DLG1/ACTN1	3
GO:1901612	cardiolipin binding	3/2244	11/18367	0.142214510621321	0.492142959468735	MME/NME4/STOML2	3
GO:0004697	protein kinase C activity	4/2244	17/18367	0.1450289818686	0.495628638971508	PRKCZ/PRKCH/PRKCI/CCL3	4
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	4/2244	17/18367	0.1450289818686	0.495628638971508	PYCARD/BAD/CASP1/CTSH	4
GO:0030275	LRR domain binding	4/2244	17/18367	0.1450289818686	0.495628638971508	PAWR/ERC1/PMF1/POLR2J	4
GO:0050780	dopamine receptor binding	4/2244	17/18367	0.1450289818686	0.495628638971508	GNAS/GNA12/ARRB2/PTPN11	4
GO:0034062	5'-3' RNA polymerase activity	8/2244	43/18367	0.147438237604511	0.500742249697053	POLR2L/POLR2I/POLR2H/POLR2F/POLR2K/POLR2G/POLR3K/POLR2J	8
GO:0097747	RNA polymerase activity	8/2244	43/18367	0.147438237604511	0.500742249697053	POLR2L/POLR2I/POLR2H/POLR2F/POLR2K/POLR2G/POLR3K/POLR2J	8
GO:0030414	peptidase inhibitor activity	28/2244	187/18367	0.148420873573008	0.502302226284235	ITIH5/SPINT1/CRIM1/SERPINF1/SERPINH1/SPINT2/PEBP1/TIMP3/APP/CST3/PRDX5/SERPINA1/CARD16/CSTA/BST2/BIRC5/USP14/GPC3/TIMP1/ANXA2/PRDX3/SERPINB1/PTTG1/TNFAIP8/NAIP/TIMP2/CSTB/RPS6KA1	28
GO:0005048	signal sequence binding	9/2244	50/18367	0.15031598365487	0.502302226284235	NFKBIA/NUP214/SRP14/TNPO1/KDELR1/KPNA2/KDELR2/AP2M1/TOMM20	9
GO:0015485	cholesterol binding	9/2244	50/18367	0.15031598365487	0.502302226284235	TSPO/NPC2/ABCA1/CAV1/VDAC1/CD81/VDAC2/STARD4/OSBPL8	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	9/2244	50/18367	0.15031598365487	0.502302226284235	SLC35B4/SLC19A1/SLC25A4/SLC29A1/SLC25A36/SLC25A5/SLC29A3/HNRNPA3/SLC25A6	9
GO:0008013	beta-catenin binding	14/2244	85/18367	0.15053968962875	0.502302226284235	CDH1/GJA1/KANK1/DLG5/GLI3/CBY1/FOXO4/CD2AP/DVL3/TBL1X/CTNNB1/SKP1/KLF4/RUVBL2	14
GO:0004866	endopeptidase inhibitor activity	27/2244	180/18367	0.151334312800354	0.502302226284235	ITIH5/SPINT1/CRIM1/SERPINF1/SERPINH1/SPINT2/PEBP1/TIMP3/APP/CST3/PRDX5/SERPINA1/CARD16/CSTA/BST2/BIRC5/USP14/TIMP1/ANXA2/PRDX3/SERPINB1/PTTG1/TNFAIP8/NAIP/TIMP2/CSTB/RPS6KA1	27
GO:0001221	transcription coregulator binding	13/2244	78/18367	0.151583710738941	0.502302226284235	EPAS1/BAIAP2/TFAM/EZH2/STAT1/EED/VGLL4/RPL23/CTNNB1/KLF4/SUZ12/LMO2/CBX3	13
GO:0022829	wide pore channel activity	6/2244	30/18367	0.15201854068037	0.502302226284235	GJA1/GJA5/VDAC1/TOMM40/VDAC2/VDAC3	6
GO:0046966	thyroid hormone receptor binding	6/2244	30/18367	0.15201854068037	0.502302226284235	TRIP6/HMGN3/FUS/NCOA3/TAF11/MED16	6
GO:1901981	phosphatidylinositol phosphate binding	26/2244	173/18367	0.154306292845435	0.508330340094423	SYT7/FERMT2/PHLDA2/PHLDA3/SCIN/PLEKHF1/PARD3/PLEKHA5/ARHGAP32/SLC9A1/ANXA2/CYTH3/PLEKHA8/CAPG/SNX24/COMMD1/EXOC1/SNX3/MYO1G/IQGAP1/SDCBP/DAPP1/IQGAP2/ARHGAP9/NCF4/OSBPL8	26
GO:0043531	ADP binding	7/2244	37/18367	0.158450486420692	0.520419711387723	MYH10/MYO7A/MSH6/RUVBL1/RUVBL2/VCP/TAP1	7
GO:0008171	O-methyltransferase activity	5/2244	24/18367	0.161342242691132	0.523646272876246	COMT/LCMT1/COMTD1/ICMT/ARMT1	5
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	5/2244	24/18367	0.161342242691132	0.523646272876246	CDO1/ADI1/PIR/ETHE1/ALOX5	5
GO:0019789	SUMO transferase activity	5/2244	24/18367	0.161342242691132	0.523646272876246	TRIM28/CBX4/KIAA1586/ZNF451/MDM2	5
GO:0070840	dynein complex binding	5/2244	24/18367	0.161342242691132	0.523646272876246	CENPF/GPSM2/ATMIN/SMC3/DCTN6	5
GO:0046332	SMAD binding	13/2244	79/18367	0.162385053184573	0.525476116057454	TGFBR3/FERMT2/PARP1/FOS/PPARG/DAB2/FLNA/EID2/PURA/USP15/CTNNB1/USP9X/JUN	13
GO:0051018	protein kinase A binding	9/2244	51/18367	0.163988405544114	0.529103767299684	RPS3/WASF2/LRRK2/RDX/AKAP1/EZR/AKAP13/AKAP9/CSK	9
GO:0030295	protein kinase activator activity	16/2244	101/18367	0.16667071684845	0.536181162412756	CD24/ERBB3/CKS1B/TPX2/IGF2/CCNB1/HMGB1/CKS2/DAZAP2/MNAT1/RPLP1/MOB1A/NCKAP1L/IQGAP1/PAK2/STK4	16
GO:0046624	sphingolipid transporter activity	4/2244	18/18367	0.169472256755316	0.538430536007732	ABCB1/ATP10D/ABCA1/PLEKHA8	4
GO:0098918	structural constituent of synapse	4/2244	18/18367	0.169472256755316	0.538430536007732	ACTB/DLG1/ERC1/ACTN1	4
GO:0008157	protein phosphatase 1 binding	6/2244	31/18367	0.170255078360932	0.538430536007732	PPP1R9A/LILRB2/STAU1/LILRB1/C20orf27/PPP1R15A	6
GO:0003995	acyl-CoA dehydrogenase activity	3/2244	12/18367	0.173259780502032	0.538430536007732	TECR/ACADVL/ACADS	3
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	3/2244	12/18367	0.173259780502032	0.538430536007732	CDKN1C/HEXIM1/CDKN2A	3
GO:0008429	phosphatidylethanolamine binding	3/2244	12/18367	0.173259780502032	0.538430536007732	PEBP1/NF1/CD300A	3
GO:0033130	acetylcholine receptor binding	3/2244	12/18367	0.173259780502032	0.538430536007732	UBXN2A/JAK2/RER1	3
GO:0043047	single-stranded telomeric DNA binding	3/2244	12/18367	0.173259780502032	0.538430536007732	RAD50/HNRNPA1/RPA2	3
GO:0043422	protein kinase B binding	3/2244	12/18367	0.173259780502032	0.538430536007732	BAD/ARRB2/CCDC88A	3
GO:0046790	virion binding	3/2244	12/18367	0.173259780502032	0.538430536007732	ANXA2/PPIA/TSG101	3
GO:0097677	STAT family protein binding	3/2244	12/18367	0.173259780502032	0.538430536007732	PPARG/SPI1/PARP9	3
GO:1900750	oligopeptide binding	3/2244	12/18367	0.173259780502032	0.538430536007732	PTGES/PTGES2/MGST1	3
GO:0140104	molecular carrier activity	12/2244	73/18367	0.175440370676082	0.543666911388877	RAN/NUP214/NDUFAB1/TNPO1/NUTF2/KPNA2/EMC7/FXN/PARK7/HSPA8/EMC6/SCO2	12
GO:0002039	p53 binding	11/2244	66/18367	0.176950972753197	0.545267463792858	TRIM29/HSPD1/SMYD2/TP63/BRD4/TRIAP1/TRIM24/BRD7/USP10/MDM2/PTTG1IP	11
GO:0043022	ribosome binding	11/2244	66/18367	0.176950972753197	0.545267463792858	RPSA/RPN2/C1QBP/HSPA5/MRPS27/CCDC47/ETF1/SBDS/NAA10/SERBP1/OLA1	11
GO:0030247	polysaccharide binding	5/2244	25/18367	0.182696557939792	0.559827162178638	AGL/HLA-DRA/HLA-DRB1/CLEC7A/GPCPD1	5
GO:0035035	histone acetyltransferase binding	5/2244	25/18367	0.182696557939792	0.559827162178638	GLI3/PCNA/CEBPB/STAT1/EID1	5
GO:0017022	myosin binding	12/2244	74/18367	0.187644586261981	0.573387496182155	CALD1/CORO1A/DMD/PYCARD/RAB25/RHOA/FUS/RALA/TRIOBP/CXCR4/RAB6A/MYL12B	12
GO:0015605	organophosphate ester transmembrane transporter activity	6/2244	32/18367	0.189344732364473	0.575377206104784	SLC19A1/SLC25A4/SLC29A1/SLC25A36/SLC25A5/SLC25A6	6
GO:0051721	protein phosphatase 2A binding	6/2244	32/18367	0.189344732364473	0.575377206104784	STAT1/BOD1/PTPN1/BCL2/ENSA/EIF4EBP1	6
GO:0032934	sterol binding	10/2244	60/18367	0.19174141883675	0.580987159381467	TSPO/NPC2/ABCA1/CAV1/VDAC1/OSBPL9/CD81/VDAC2/STARD4/OSBPL8	10
GO:0046943	carboxylic acid transmembrane transporter activity	24/2244	163/18367	0.192250080998607	0.580987159381467	SLC26A2/SLC27A2/SLC38A1/SLC16A12/ABCB1/SLC16A4/SLC13A3/SLC19A1/SLC16A1/MPC2/SLC38A9/SLC16A2/SLC5A6/SLC1A3/SLC7A2/SFXN1/SLC1A5/CD36/SLC43A2/SLC25A13/SLC7A7/SLC3A2/SLC25A1/SLC16A3	24
GO:0005342	organic acid transmembrane transporter activity	24/2244	164/18367	0.200675901915667	0.600972224167977	SLC26A2/SLC27A2/SLC38A1/SLC16A12/ABCB1/SLC16A4/SLC13A3/SLC19A1/SLC16A1/MPC2/SLC38A9/SLC16A2/SLC5A6/SLC1A3/SLC7A2/SFXN1/SLC1A5/CD36/SLC43A2/SLC25A13/SLC7A7/SLC3A2/SLC25A1/SLC16A3	24
GO:0004364	glutathione transferase activity	5/2244	26/18367	0.205015133213896	0.600972224167977	PTGES/GSTP1/GSTA4/GSTZ1/MGST1	5
GO:0008198	ferrous iron binding	5/2244	26/18367	0.205015133213896	0.600972224167977	CDO1/FTL/FTH1/ISCU/FXN	5
GO:0030371	translation repressor activity	5/2244	26/18367	0.205015133213896	0.600972224167977	TYMS/DHFR/CIRBP/PURA/EIF4EBP1	5
GO:0097602	cullin family protein binding	5/2244	26/18367	0.205015133213896	0.600972224167977	DDB1/ANAPC11/DCUN1D5/SKP1/RBX1	5
GO:0004859	phospholipase inhibitor activity	3/2244	13/18367	0.205965646730817	0.600972224167977	ANXA3/ANXA5/ANXA2	3
GO:0008035	high-density lipoprotein particle binding	3/2244	13/18367	0.205965646730817	0.600972224167977	HSPD1/ABCA1/CD36	3
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	3/2244	13/18367	0.205965646730817	0.600972224167977	GLRX/PRDX3/TXN	3
GO:0016840	carbon-nitrogen lyase activity	3/2244	13/18367	0.205965646730817	0.600972224167977	GGCT/APMAP/ADSL	3
GO:0034450	ubiquitin-ubiquitin ligase activity	3/2244	13/18367	0.205965646730817	0.600972224167977	ANAPC11/UBE4B/RBX1	3
GO:0042301	phosphate ion binding	3/2244	13/18367	0.205965646730817	0.600972224167977	GNG12/PNP/CHST14	3
GO:0052650	NADP-retinol dehydrogenase activity	3/2244	13/18367	0.205965646730817	0.600972224167977	AKR1B1/DHRS3/RDH14	3
GO:0015179	L-amino acid transmembrane transporter activity	10/2244	61/18367	0.205985010289115	0.600972224167977	SLC38A1/SLC38A9/SLC1A3/SLC7A2/SFXN1/SLC1A5/SLC43A2/SLC25A13/SLC7A7/SLC3A2	10
GO:0015459	potassium channel regulator activity	9/2244	54/18367	0.208274062361819	0.606038849896328	RASA1/PRKCZ/SLC5A3/FLNA/DLG1/CAV1/YWHAE/ENSA/AKAP9	9
GO:0001530	lipopolysaccharide binding	6/2244	33/18367	0.20920789053361	0.607145650569762	CD14/HSPD1/HMGB1/LY96/PSMB4/TLR2	6
GO:0017080	sodium channel regulator activity	7/2244	40/18367	0.210413964102819	0.609034613775179	FXYD3/PRSS8/FXYD5/NEDD4/PKP2/RANGRF/COMMD1	7
GO:1901681	sulfur compound binding	37/2244	265/18367	0.215241190275006	0.621367330872847	FBN1/ADGRG1/NRP2/CCDC80/BMP7/ADAMTS1/TGFBR3/FSTL1/SMOC1/PTPRF/PCOLCE2/APP/PTPRC/NRP1/PTN/ACBD6/SOD3/LRPAP1/PTGES/GSTP1/NAV2/ECI2/ACADVL/LAMC2/PDCD5/PPIA/VEGFB/MDK/DBI/SELL/PRMT1/ILVBL/RPL22/PTGES2/SULT1A1/TKT/MGST1	37
GO:0008201	heparin binding	24/2244	166/18367	0.218060230296405	0.627853209016157	FBN1/ADGRG1/NRP2/CCDC80/BMP7/ADAMTS1/TGFBR3/FSTL1/SMOC1/PTPRF/PCOLCE2/APP/PTPRC/NRP1/PTN/SOD3/LRPAP1/NAV2/LAMC2/PDCD5/VEGFB/MDK/SELL/RPL22	24
GO:0004721	phosphoprotein phosphatase activity	25/2244	174/18367	0.221672005597465	0.632754299311394	DUSP9/PTPRF/PTPRC/DUSP1/DUSP14/PTPN14/CTDSPL/CAMK2G/DUSP5/UBASH3B/DLG1/PHLPP1/PGP/ACP1/PTP4A1/LRRK2/PTPN6/PTPN1/TIMM50/PTP4A2/PTPN11/DUSP6/PPM1G/PPP2CB/PHPT1	25
GO:0001091	RNA polymerase II general transcription initiation factor binding	4/2244	20/18367	0.222069649256961	0.632754299311394	NOP58/RUVBL1/RUVBL2/EDF1	4
GO:0030506	ankyrin binding	4/2244	20/18367	0.222069649256961	0.632754299311394	CDH1/PTPRC/SPTBN1/SLC8A1	4
GO:0097001	ceramide binding	4/2244	20/18367	0.222069649256961	0.632754299311394	PSAP/VDAC1/PLEKHA8/VDAC2	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	21/2244	144/18367	0.224520950065661	0.636432770599562	AGL/LYZ/TLR3/FUCA1/GANAB/UNG/PCNA/NAGLU/OARD1/MAN1B1/TDG/DNPH1/GAA/HEXA/PIK3AP1/BST1/TLR2/APEX1/HEXB/HPSE/TLR8	21
GO:0016922	nuclear receptor binding	21/2244	144/18367	0.224520950065661	0.636432770599562	ISL1/TACC2/PARP1/PPARG/HMGA1/TRIP6/HMGN3/CALR/PCNA/CEBPB/STAT1/TRIM24/FUS/NCOA3/SMARCE1/TAF11/MED16/CTNNB1/PARK7/NR4A1/PHB2	21
GO:0003724	RNA helicase activity	12/2244	77/18367	0.226473539518573	0.636906722018491	DDX3Y/MOV10/G3BP1/DDX1/DDX56/DHX32/EIF4A1/DDX24/DDX18/DHX36/DDX52/DDX46	12
GO:0001671	ATPase activator activity	5/2244	27/18367	0.22817168801574	0.636906722018491	DNAJB4/TOR1AIP2/DNAJC19/AHSA1/DNAJB6	5
GO:0016866	intramolecular transferase activity	5/2244	27/18367	0.22817168801574	0.636906722018491	PGM1/PMM2/PGM3/TRUB2/CYP2J2	5
GO:0030507	spectrin binding	5/2244	27/18367	0.22817168801574	0.636906722018491	PTPRC/ANK3/MYO7A/CAMSAP2/GBP1	5
GO:0043425	bHLH transcription factor binding	5/2244	27/18367	0.22817168801574	0.636906722018491	ISL1/BHLHE41/KLF5/FHL2/LMO2	5
GO:0070006	metalloaminopeptidase activity	5/2244	27/18367	0.22817168801574	0.636906722018491	ENPEP/MMP15/MMP14/LAP3/METAP2	5
GO:0016877	ligase activity, forming carbon-sulfur bonds	7/2244	41/18367	0.228996853095149	0.637032206694832	SLC27A2/ACSS1/NAE1/SUCLG1/SAE1/UBA2/ACSL1	7
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	6/2244	34/18367	0.229760404205289	0.637032206694832	FEN1/POP7/RNASEH2A/AGO2/RPP30/APEX1	6
GO:0019209	kinase activator activity	16/2244	107/18367	0.230656968321173	0.637032206694832	CD24/ERBB3/CKS1B/TPX2/IGF2/CCNB1/HMGB1/CKS2/DAZAP2/MNAT1/RPLP1/MOB1A/NCKAP1L/IQGAP1/PAK2/STK4	16
GO:0001098	basal transcription machinery binding	11/2244	70/18367	0.231120162501862	0.637032206694832	SMYD2/BRD4/RTF1/NOP58/WDR43/ZNF326/NCOA3/RUVBL1/AGO2/RUVBL2/EDF1	11
GO:0001099	basal RNA polymerase II transcription machinery binding	11/2244	70/18367	0.231120162501862	0.637032206694832	SMYD2/BRD4/RTF1/NOP58/WDR43/ZNF326/NCOA3/RUVBL1/AGO2/RUVBL2/EDF1	11
GO:0016247	channel regulator activity	21/2244	145/18367	0.234301117388792	0.644181267607782	TSPAN13/FXYD3/RASA1/PRSS8/FXYD5/PACSIN3/PRKCZ/SLC5A3/FLNA/NEDD4/DLG1/CAV1/PKP2/YWHAE/BCL2/RANGRF/COMMD1/PHPT1/ENSA/VAMP8/AKAP9	21
GO:0015926	glucosidase activity	3/2244	14/18367	0.239898626874246	0.649799490570487	AGL/GANAB/GAA	3
GO:0017110	nucleoside-diphosphatase activity	3/2244	14/18367	0.239898626874246	0.649799490570487	NUDT15/NUDT5/ENTPD1	3
GO:0030983	mismatched DNA binding	3/2244	14/18367	0.239898626874246	0.649799490570487	PCNA/MSH6/TDG	3
GO:0036041	long-chain fatty acid binding	3/2244	14/18367	0.239898626874246	0.649799490570487	S100A8/S100A9/PPARG	3
GO:0043023	ribosomal large subunit binding	3/2244	14/18367	0.239898626874246	0.649799490570487	NPM1/MALSU1/OLA1	3
GO:0071837	HMG box domain binding	3/2244	14/18367	0.239898626874246	0.649799490570487	GATA3/DLX5/JUN	3
GO:0005539	glycosaminoglycan binding	32/2244	230/18367	0.241362004519591	0.652153002359584	FBN1/ADGRG1/NRP2/CCDC80/BMP7/ADAMTS1/TGFBR3/EXTL2/FSTL1/SMOC1/PTPRF/PCOLCE2/APP/PTPRC/NRP1/PTN/VCAN/SOD3/LRPAP1/NAV2/LAMC2/CD44/HMMR/C1QBP/PDCD5/PPIA/VEGFB/MDK/SELL/RPL22/TLR2/NLRP3	32
GO:0032813	tumor necrosis factor receptor superfamily binding	8/2244	49/18367	0.244398144417855	0.657119520652908	TNFSF10/TRAF4/TNFSF13B/TRAP1/STAT1/SIVA1/TNF/BID	8
GO:0043539	protein serine/threonine kinase activator activity	8/2244	49/18367	0.244398144417855	0.657119520652908	CKS1B/IGF2/CCNB1/CKS2/DAZAP2/MNAT1/IQGAP1/STK4	8
GO:0004540	ribonuclease activity	17/2244	116/18367	0.247639753161822	0.659867218521088	REXO2/FEN1/SAMHD1/POP7/RCL1/RNASEH2A/RNASET2/SND1/AGO2/ERI3/EXOSC9/EXOSC7/EXOSC3/RPP30/APEX1/RNASE6/RNASE2	17
GO:0008307	structural constituent of muscle	7/2244	42/18367	0.248108161214607	0.659867218521088	DAG1/CSRP2/ASPH/DMD/KRT19/MYL6B/TPM1	7
GO:0005385	zinc ion transmembrane transporter activity	4/2244	21/18367	0.249797358958867	0.659867218521088	SLC39A10/SLC39A1/SLC30A5/SLC39A7	4
GO:0070577	lysine-acetylated histone binding	4/2244	21/18367	0.249797358958867	0.659867218521088	BRD4/YEATS4/TRIM24/BRD7	4
GO:0140033	acetylation-dependent protein binding	4/2244	21/18367	0.249797358958867	0.659867218521088	BRD4/YEATS4/TRIM24/BRD7	4
GO:1990381	ubiquitin-specific protease binding	4/2244	21/18367	0.249797358958867	0.659867218521088	VCP/PARK7/RAD23A/CLTC	4
GO:0099106	ion channel regulator activity	20/2244	139/18367	0.250479758212578	0.659867218521088	TSPAN13/FXYD3/RASA1/PRSS8/FXYD5/PACSIN3/PRKCZ/SLC5A3/FLNA/NEDD4/DLG1/CAV1/PKP2/YWHAE/RANGRF/COMMD1/PHPT1/ENSA/VAMP8/AKAP9	20
GO:0042887	amide transmembrane transporter activity	6/2244	35/18367	0.250914930632202	0.659867218521088	GJA1/SLC13A3/SLC19A1/SLC5A6/TAPBP/TAP1	6
GO:0003953	NAD+ nucleosidase activity	5/2244	28/18367	0.252036795405958	0.659867218521088	TLR3/PIK3AP1/BST1/TLR2/TLR8	5
GO:0015101	organic cation transmembrane transporter activity	5/2244	28/18367	0.252036795405958	0.659867218521088	SLC19A3/SLC29A1/SLC44A2/ATP13A3/SLC44A1	5
GO:1990756	ubiquitin ligase-substrate adaptor activity	5/2244	28/18367	0.252036795405958	0.659867218521088	ANKRD9/KLHDC2/PEF1/SKP1/PDCD6	5
GO:0008186	ATP-dependent activity, acting on RNA	12/2244	79/18367	0.254007153010119	0.663442492505001	DDX3Y/MOV10/G3BP1/DDX1/DDX56/DHX32/EIF4A1/DDX24/DDX18/DHX36/DDX52/DDX46	12
GO:0005516	calmodulin binding	28/2244	201/18367	0.256844801790229	0.669260683049599	EGFR/MYH10/CALD1/KCNN4/SYT7/TJP1/ASPM/MYO1C/MYO7A/CAMK2G/CNN3/SPTBN1/TRPV6/WFS1/SLC9A1/CAMSAP2/NDUFAF4/RGS2/ATP2B1/MARCKS/MYO1F/MYO1G/EEA1/IQGAP1/EDF1/CNN2/SLC8A1/IQGAP2	28
GO:0030159	signaling receptor complex adaptor activity	8/2244	50/18367	0.262318555991756	0.681903923988049	DLG5/SORBS1/NCK2/LRRK2/DOK2/CRK/PTPN11/SPAG9	8
GO:0016790	thiolester hydrolase activity	7/2244	43/18367	0.267682868583237	0.685801564079105	FASN/HIBCH/ABHD12/LYPLAL1/PNKD/PPT1/LYPLA1	7
GO:0032266	phosphatidylinositol-3-phosphate binding	7/2244	43/18367	0.267682868583237	0.685801564079105	PHLDA3/PLEKHF1/PARD3/PLEKHA5/SNX24/SNX3/NCF4	7
GO:0015248	sterol transporter activity	6/2244	36/18367	0.272582203144776	0.685801564079105	TSPO/NPC2/ABCA1/OSBPL9/STARD4/OSBPL8	6
GO:0008028	monocarboxylic acid transmembrane transporter activity	9/2244	58/18367	0.27367982890948	0.685801564079105	SLC27A2/SLC16A12/SLC16A4/SLC16A1/MPC2/SLC16A2/SLC5A6/CD36/SLC16A3	9
GO:0015631	tubulin binding	50/2244	375/18367	0.274420388508204	0.685801564079105	GJA1/DAG1/CENPF/S100A8/S100A9/BEX4/KIFC3/RPS3/CNN3/HOOK2/CAPN6/DST/GPAA1/PRC1/STMN1/MAP9/TPX2/BIRC5/EML2/CAMSAP2/LYN/BRCA2/PDCD5/TBCA/NME1/KIF21A/RGS2/SMC3/KIF20B/CLIP1/SKA2/LRRK2/GABARAPL1/MAP7D3/LRPPRC/MX1/EML4/DRG1/EZR/SBDS/NUSAP1/KATNBL1/MX2/GABARAPL2/FNTA/CACYBP/KIF22/CCT5/CCDC88A/FYN	50
GO:0005041	low-density lipoprotein particle receptor activity	3/2244	15/18367	0.274653137785236	0.685801564079105	LRP2/CD36/SORL1	3
GO:0005545	1-phosphatidylinositol binding	3/2244	15/18367	0.274653137785236	0.685801564079105	SCIN/SNX10/EEA1	3
GO:0015929	hexosaminidase activity	3/2244	15/18367	0.274653137785236	0.685801564079105	NAGLU/HEXA/HEXB	3
GO:0019215	intermediate filament binding	3/2244	15/18367	0.274653137785236	0.685801564079105	VIM/NME1/PKP2	3
GO:0071933	Arp2/3 complex binding	3/2244	15/18367	0.274653137785236	0.685801564079105	GMFG/WASF2/IQGAP2	3
GO:0098847	sequence-specific single stranded DNA binding	3/2244	15/18367	0.274653137785236	0.685801564079105	RAD50/HNRNPA1/RPA2	3
GO:1901611	phosphatidylglycerol binding	3/2244	15/18367	0.274653137785236	0.685801564079105	MME/NME4/STOML2	3
GO:0008276	protein methyltransferase activity	13/2244	88/18367	0.274968658418612	0.685801564079105	SMYD2/LCMT1/DNMT3A/PRMT7/EZH2/PRMT1/ICMT/EED/FAM98B/TRMT112/ARMT1/SUZ12/NTMT1	13
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5/2244	29/18367	0.276480127493108	0.685801564079105	CDK6/CDK7/CDK4/CDK1/CCND3	5
GO:0015301	anion:anion antiporter activity	5/2244	29/18367	0.276480127493108	0.685801564079105	SLC26A2/SLC19A1/SLC25A4/SLC25A5/SLC25A6	5
GO:0097472	cyclin-dependent protein kinase activity	5/2244	29/18367	0.276480127493108	0.685801564079105	CDK6/CDK7/CDK4/CDK1/CCND3	5
GO:0000062	fatty-acyl-CoA binding	4/2244	22/18367	0.278196623532545	0.685801564079105	ACBD6/ECI2/ACADVL/DBI	4
GO:0005355	glucose transmembrane transporter activity	4/2244	22/18367	0.278196623532545	0.685801564079105	SLC2A1/SLC2A8/SLC5A3/SLC2A3	4
GO:0005540	hyaluronic acid binding	4/2244	22/18367	0.278196623532545	0.685801564079105	VCAN/CD44/HMMR/C1QBP	4
GO:0008106	alcohol dehydrogenase (NADP+) activity	4/2244	22/18367	0.278196623532545	0.685801564079105	AKR1B1/DHRS3/RDH14/AKR7A2	4
GO:0015149	hexose transmembrane transporter activity	4/2244	22/18367	0.278196623532545	0.685801564079105	SLC2A1/SLC2A8/SLC5A3/SLC2A3	4
GO:0015296	anion:cation symporter activity	4/2244	22/18367	0.278196623532545	0.685801564079105	SLC13A4/SLC6A4/SLC12A4/SLC12A9	4
GO:0120020	cholesterol transfer activity	4/2244	22/18367	0.278196623532545	0.685801564079105	TSPO/NPC2/ABCA1/STARD4	4
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	6/2244	37/18367	0.294672212833308	0.723166482054002	ALDH7A1/AKR1B1/ALDH1A3/ADH5/ALDH2/PDHA1	6
GO:0046915	transition metal ion transmembrane transporter activity	6/2244	37/18367	0.294672212833308	0.723166482054002	SLC40A1/SLC39A10/SLC39A1/SLC30A5/SLC39A7/SLC11A1	6
GO:0031593	polyubiquitin modification-dependent protein binding	8/2244	52/18367	0.299228313457349	0.724762961731001	AGL/OTUD7B/OPTN/RAD23B/VCP/RAD23A/PSMD4/TNFAIP3	8
GO:0005543	phospholipid binding	61/2244	466/18367	0.300300640353335	0.724762961731001	MME/SYT7/FERMT2/PEBP1/PHLDA2/EPN2/PHLDA3/SCIN/ANXA3/PLEKHF1/PARD3/PLEKHA5/NCF1/SH3YL1/OPHN1/PSAP/SPTBN1/ARHGAP32/MICALL1/GPAA1/BAD/ANXA5/PACSIN3/NME4/SLC9A1/PXDC1/NF1/ABCA1/STOML2/ANXA2/SNX4/CYTH3/VDAC1/PLEKHA8/PRKCI/CAPG/SNX24/HMGB1/GOT2/SNX10/ING2/VDAC2/COMMD1/PPT1/HSPA8/EXOC1/CPNE1/SNX3/MYO1G/EEA1/IQGAP1/SDCBP/TPP1/DAPP1/CCDC88A/CD300A/ARHGAP26/IQGAP2/ARHGAP9/NCF4/OSBPL8	61
GO:0005310	dicarboxylic acid transmembrane transporter activity	5/2244	30/18367	0.301372444855655	0.724762961731001	SLC26A2/SLC13A3/SLC19A1/SLC1A5/SLC25A13	5
GO:0003950	NAD+ ADP-ribosyltransferase activity	4/2244	23/18367	0.307064789047599	0.724762961731001	PARP1/PARP2/PARP9/PARP14	4
GO:0008483	transaminase activity	4/2244	23/18367	0.307064789047599	0.724762961731001	GFPT1/OAT/GOT1/GOT2	4
GO:0009931	calcium-dependent protein serine/threonine kinase activity	4/2244	23/18367	0.307064789047599	0.724762961731001	PRKCZ/PRKCH/PRKCI/CCL3	4
GO:0017025	TBP-class protein binding	4/2244	23/18367	0.307064789047599	0.724762961731001	TAF11/RUVBL1/RUVBL2/GTF2A2	4
GO:0019865	immunoglobulin binding	4/2244	23/18367	0.307064789047599	0.724762961731001	FCER1G/FCGRT/FCGR2A/FCGR1A	4
GO:0050750	low-density lipoprotein particle receptor binding	4/2244	23/18367	0.307064789047599	0.724762961731001	HSP90B1/LRPAP1/AP2M1/CLTC	4
GO:0070412	R-SMAD binding	4/2244	23/18367	0.307064789047599	0.724762961731001	PARP1/FOS/PPARG/JUN	4
GO:0120015	sterol transfer activity	4/2244	23/18367	0.307064789047599	0.724762961731001	TSPO/NPC2/ABCA1/STARD4	4
GO:0140103	catalytic activity, acting on a glycoprotein	4/2244	23/18367	0.307064789047599	0.724762961731001	B3GNT3/FUT8/B4GALT7/C1GALT1	4
GO:1901567	fatty acid derivative binding	4/2244	23/18367	0.307064789047599	0.724762961731001	ACBD6/ECI2/ACADVL/DBI	4
GO:0001786	phosphatidylserine binding	9/2244	60/18367	0.308411409314807	0.724762961731001	MME/SYT7/SCIN/ANXA2/HMGB1/HSPA8/CPNE1/CD300A/OSBPL8	9
GO:0000900	translation repressor activity, mRNA regulatory element binding	3/2244	16/18367	0.309857638151175	0.724762961731001	TYMS/DHFR/PURA	3
GO:0005523	tropomyosin binding	3/2244	16/18367	0.309857638151175	0.724762961731001	CALD1/S100A6/PYCARD	3
GO:0015172	acidic amino acid transmembrane transporter activity	3/2244	16/18367	0.309857638151175	0.724762961731001	SLC1A3/SLC1A5/SLC25A13	3
GO:0015556	C4-dicarboxylate transmembrane transporter activity	3/2244	16/18367	0.309857638151175	0.724762961731001	SLC13A3/SLC1A5/SLC25A13	3
GO:0016004	phospholipase activator activity	3/2244	16/18367	0.309857638151175	0.724762961731001	PDPK1/CCL3/FYN	3
GO:0035497	cAMP response element binding	3/2244	16/18367	0.309857638151175	0.724762961731001	CREB3L2/CREB3/JUN	3
GO:0070403	NAD+ binding	3/2244	16/18367	0.309857638151175	0.724762961731001	ALDH1A3/HPGD/UXS1	3
GO:0140327	flippase activity	3/2244	16/18367	0.309857638151175	0.724762961731001	ABCB1/ATP10D/TMEM30B	3
GO:0015175	neutral amino acid transmembrane transporter activity	6/2244	38/18367	0.317095289975614	0.735517850479426	SLC38A1/SLC38A9/SFXN1/SLC1A5/SLC43A2/SLC3A2	6
GO:0044390	ubiquitin-like protein conjugating enzyme binding	6/2244	38/18367	0.317095289975614	0.735517850479426	RPS3/SIAH1/SIAH2/DCUN1D5/PARK7/UBA2	6
GO:0043621	protein self-association	9/2244	61/18367	0.326139055300023	0.735517850479426	SLC2A1/PPARG/SVIP/GPSM2/TDG/MDH2/CRK/CTSC/TNFAIP3	9
GO:0000146	microfilament motor activity	5/2244	31/18367	0.326587323027718	0.735517850479426	MYH10/MYO1C/MYO7A/MYO1F/MYO1G	5
GO:0071813	lipoprotein particle binding	5/2244	31/18367	0.326587323027718	0.735517850479426	COLEC12/HSPD1/ABCA1/CD36/SORL1	5
GO:0071814	protein-lipid complex binding	5/2244	31/18367	0.326587323027718	0.735517850479426	COLEC12/HSPD1/ABCA1/CD36/SORL1	5
GO:0140142	nucleocytoplasmic carrier activity	5/2244	31/18367	0.326587323027718	0.735517850479426	RAN/NUP214/TNPO1/NUTF2/KPNA2	5
GO:0140296	general transcription initiation factor binding	7/2244	46/18367	0.328521804457288	0.735517850479426	NOP58/TAF11/RUVBL1/RUVBL2/GTF2A2/PSMC5/EDF1	7
GO:0004521	endoribonuclease activity	10/2244	69/18367	0.332638042788503	0.735517850479426	FEN1/POP7/RCL1/RNASEH2A/RNASET2/SND1/AGO2/RPP30/APEX1/RNASE2	10
GO:0005496	steroid binding	14/2244	100/18367	0.335537516634335	0.735517850479426	HSD17B1/TSPO/NPC2/ESRRG/ESRRA/ABCA1/CAV1/PGRMC2/VDAC1/OSBPL9/CD81/VDAC2/STARD4/OSBPL8	14
GO:0004622	lysophospholipase activity	4/2244	24/18367	0.336209298318893	0.735517850479426	MGLL/ABHD12/LYPLAL1/LYPLA1	4
GO:0010857	calcium-dependent protein kinase activity	4/2244	24/18367	0.336209298318893	0.735517850479426	PRKCZ/PRKCH/PRKCI/CCL3	4
GO:0015145	monosaccharide transmembrane transporter activity	4/2244	24/18367	0.336209298318893	0.735517850479426	SLC2A1/SLC2A8/SLC5A3/SLC2A3	4
GO:0016769	transferase activity, transferring nitrogenous groups	4/2244	24/18367	0.336209298318893	0.735517850479426	GFPT1/OAT/GOT1/GOT2	4
GO:0019957	C-C chemokine binding	4/2244	24/18367	0.336209298318893	0.735517850479426	ZFP36/CXCR4/CCR1/CCR2	4
GO:0043495	protein-membrane adaptor activity	4/2244	24/18367	0.336209298318893	0.735517850479426	SYNE2/SUN1/JUP/PDCD6	4
GO:0008408	3'-5' exonuclease activity	8/2244	54/18367	0.337216154197541	0.735517850479426	REXO2/RAD1/RAD50/ERI3/EXOSC9/EXOSC7/EXOSC3/APEX1	8
GO:0005504	fatty acid binding	6/2244	39/18367	0.339763077408479	0.735517850479426	S100A8/S100A9/PPARG/GSTP1/ADH5/NDUFAB1	6
GO:0050997	quaternary ammonium group binding	6/2244	39/18367	0.339763077408479	0.735517850479426	NF1/ABCA1/VDAC1/ILVBL/VDAC2/TKT	6
GO:0004659	prenyltransferase activity	3/2244	17/18367	0.345178064497442	0.735517850479426	FDPS/FDFT1/FNTA	3
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/2244	17/18367	0.345178064497442	0.735517850479426	PTPRF/PTPRC/PTPN6	3
GO:0005324	long-chain fatty acid transporter activity	3/2244	17/18367	0.345178064497442	0.735517850479426	SLC27A2/SLC2A1/CD36	3
GO:0008308	voltage-gated anion channel activity	3/2244	17/18367	0.345178064497442	0.735517850479426	VDAC1/VDAC2/VDAC3	3
GO:0015174	basic amino acid transmembrane transporter activity	3/2244	17/18367	0.345178064497442	0.735517850479426	SLC38A9/SLC7A2/SLC7A7	3
GO:0015377	cation:chloride symporter activity	3/2244	17/18367	0.345178064497442	0.735517850479426	SLC6A4/SLC12A4/SLC12A9	3
GO:0016722	oxidoreductase activity, acting on metal ions	3/2244	17/18367	0.345178064497442	0.735517850479426	FTH1/STEAP3/FXN	3
GO:0019198	transmembrane receptor protein phosphatase activity	3/2244	17/18367	0.345178064497442	0.735517850479426	PTPRF/PTPRC/PTPN6	3
GO:0030169	low-density lipoprotein particle binding	3/2244	17/18367	0.345178064497442	0.735517850479426	COLEC12/CD36/SORL1	3
GO:0031489	myosin V binding	3/2244	17/18367	0.345178064497442	0.735517850479426	RAB25/FUS/RAB6A	3
GO:0046965	retinoid X receptor binding	3/2244	17/18367	0.345178064497442	0.735517850479426	PPARG/HMGA1/FUS	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	7/2244	47/18367	0.349284138516458	0.735517850479426	DUSP9/DUSP1/DUSP14/DUSP5/PTP4A1/PTP4A2/DUSP6	7
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	ACP1/PTPN11	2
GO:0004955	prostaglandin receptor activity	2/2244	10/18367	0.350178291554461	0.735517850479426	PPARG/HPGD	2
GO:0005031	tumor necrosis factor-activated receptor activity	2/2244	10/18367	0.350178291554461	0.735517850479426	TNFRSF1B/TNFRSF14	2
GO:0005432	calcium:sodium antiporter activity	2/2244	10/18367	0.350178291554461	0.735517850479426	SLC3A2/SLC8A1	2
GO:0008239	dipeptidyl-peptidase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	DPP4/CTSC	2
GO:0015643	toxic substance binding	2/2244	10/18367	0.350178291554461	0.735517850479426	EPHX2/ASS1	2
GO:0016595	glutamate binding	2/2244	10/18367	0.350178291554461	0.735517850479426	SLC1A3/GLUL	2
GO:0016783	sulfurtransferase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	TSTD1/MOCS2	2
GO:0016803	ether hydrolase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	EPHX2/AKR7A2	2
GO:0031419	cobalamin binding	2/2244	10/18367	0.350178291554461	0.735517850479426	MTR/MMAB	2
GO:0032356	oxidized DNA binding	2/2244	10/18367	0.350178291554461	0.735517850479426	RPS3/MSH6	2
GO:0033204	ribonuclease P RNA binding	2/2244	10/18367	0.350178291554461	0.735517850479426	POP7/RPP30	2
GO:0034511	U3 snoRNA binding	2/2244	10/18367	0.350178291554461	0.735517850479426	PRKDC/SNU13	2
GO:0034713	type I transforming growth factor beta receptor binding	2/2244	10/18367	0.350178291554461	0.735517850479426	FERMT2/TGFB1	2
GO:0035374	chondroitin sulfate binding	2/2244	10/18367	0.350178291554461	0.735517850479426	PTN/MDK	2
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	2/2244	10/18367	0.350178291554461	0.735517850479426	FAM83B/PIK3AP1	2
GO:0043139	5'-3' DNA helicase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	RUVBL1/RUVBL2	2
GO:0045503	dynein light chain binding	2/2244	10/18367	0.350178291554461	0.735517850479426	GLUL/DYNC1I2	2
GO:0047844	deoxycytidine deaminase activity	2/2244	10/18367	0.350178291554461	0.735517850479426	APOBEC3A/CDA	2
GO:0051880	G-quadruplex DNA binding	2/2244	10/18367	0.350178291554461	0.735517850479426	RAD50/DHX36	2
GO:0098505	G-rich strand telomeric DNA binding	2/2244	10/18367	0.350178291554461	0.735517850479426	HNRNPA1/RPA2	2
GO:0019842	vitamin binding	20/2244	148/18367	0.350341018332203	0.735517850479426	GLDC/FOLR1/SLC19A1/OPN3/TYMS/THNSL2/FASN/DHFR/MTR/GGCX/OAT/GOT1/GOT2/ILVBL/MMAB/OGFOD3/PDXDC1/ALAS1/TKT/RBP7	20
GO:0008378	galactosyltransferase activity	5/2244	32/18367	0.352002617594985	0.735517850479426	B3GNT3/B4GALT4/B4GALT7/C1GALT1/B4GALT1	5
GO:0030332	cyclin binding	5/2244	32/18367	0.352002617594985	0.735517850479426	CDK6/CDK4/CDK1/XRCC6/TNFAIP1	5
GO:0071889	14-3-3 protein binding	5/2244	32/18367	0.352002617594985	0.735517850479426	ZFP36/BAD/PRKCZ/HLA-F/ARRB2	5
GO:0005160	transforming growth factor beta receptor binding	4/2244	25/18367	0.365449820295865	0.757842065906549	TGFBR3/FERMT2/USP15/TGFB1	4
GO:0034237	protein kinase A regulatory subunit binding	4/2244	25/18367	0.365449820295865	0.757842065906549	WASF2/AKAP1/EZR/AKAP9	4
GO:0051019	mitogen-activated protein kinase binding	4/2244	25/18367	0.365449820295865	0.757842065906549	DUSP1/ARRB2/PRMT1/IQGAP1	4
GO:0120227	acyl-CoA binding	4/2244	25/18367	0.365449820295865	0.757842065906549	ACBD6/ECI2/ACADVL/DBI	4
GO:0048029	monosaccharide binding	10/2244	71/18367	0.366603052992777	0.758799149307691	COLEC12/LMAN1/BSG/RPIA/UGP2/SLC2A8/SLC2A3/OGFOD3/LGALS9/CLEC4A	10
GO:0120013	lipid transfer activity	7/2244	48/18367	0.370178628182105	0.764756977619152	TSPO/NPC2/ABCA1/TRIAP1/PLEKHA8/STARD4/OSBPL8	7
GO:0140323	solute:anion antiporter activity	5/2244	33/18367	0.377501675998803	0.770997401080477	SLC26A2/SLC19A1/SLC25A4/SLC25A5/SLC25A6	5
GO:0031490	chromatin DNA binding	14/2244	103/18367	0.377939942235752	0.770997401080477	ACTB/HMGN1/GRHL1/HMGN3/EZH2/ACTL6A/ZFX/SMARCE1/RUVBL2/MBD3/SUZ12/SMARCC1/APEX1/HMGN2	14
GO:0004550	nucleoside diphosphate kinase activity	3/2244	18/18367	0.380319226045867	0.770997401080477	NME4/DTYMK/NME1	3
GO:0030228	lipoprotein particle receptor activity	3/2244	18/18367	0.380319226045867	0.770997401080477	LRP2/CD36/SORL1	3
GO:0031435	mitogen-activated protein kinase kinase kinase binding	3/2244	18/18367	0.380319226045867	0.770997401080477	MARVELD3/DAZAP2/CDC42	3
GO:0047834	D-threo-aldose 1-dehydrogenase activity	3/2244	18/18367	0.380319226045867	0.770997401080477	AKR1B1/GCLM/AKR7A2	3
GO:0055102	lipase inhibitor activity	3/2244	18/18367	0.380319226045867	0.770997401080477	ANXA3/ANXA5/ANXA2	3
GO:0060229	lipase activator activity	3/2244	18/18367	0.380319226045867	0.770997401080477	PDPK1/CCL3/FYN	3
GO:0140597	protein carrier activity	3/2244	18/18367	0.380319226045867	0.770997401080477	EMC7/HSPA8/EMC6	3
GO:0030331	estrogen receptor binding	6/2244	41/18367	0.385490969537144	0.770997401080477	ISL1/PARP1/PCNA/FUS/CTNNB1/PHB2	6
GO:0005126	cytokine receptor binding	35/2244	271/18367	0.389345186008646	0.770997401080477	TGFBR3/FERMT2/GATA3/PRLR/TNFSF10/PYCARD/TRIP6/MIF/TRAF4/TNFSF13B/IL6ST/CD2AP/CCL3L3/TRAP1/STAT1/VEGFB/SIVA1/USP15/TIMM50/JAK2/CCL3/TGFB1/SYK/IL1B/TNF/JAK1/SDCBP/CSH1/DDT/CCR2/CCDC88A/CCL4/BID/ITGA5/CKLF	35
GO:0035091	phosphatidylinositol binding	35/2244	271/18367	0.389345186008646	0.770997401080477	SYT7/FERMT2/PHLDA2/PHLDA3/SCIN/PLEKHF1/PARD3/PLEKHA5/NCF1/SH3YL1/ARHGAP32/GPAA1/SLC9A1/PXDC1/ANXA2/SNX4/CYTH3/PLEKHA8/CAPG/SNX24/SNX10/ING2/COMMD1/EXOC1/SNX3/MYO1G/EEA1/IQGAP1/SDCBP/DAPP1/CCDC88A/IQGAP2/ARHGAP9/NCF4/OSBPL8	35
GO:0030695	GTPase regulator activity	62/2244	488/18367	0.390263967558051	0.770997401080477	HACD3/ADRB1/NET1/RASA1/ARHGAP23/NRP1/SYDE2/CHML/EPS8L2/DOCK9/ARHGDIB/DOCK1/OPHN1/ERRFI1/ARHGAP32/GPSM2/SH2D3A/SMAP2/NF1/RANBP1/VAV3/RAB3IP/ARHGAP10/CYTH3/RGS2/DEPDC1/FAM13A/ECT2/DENND4C/RHOD/GPSM3/ARF4/ARHGAP18/ARHGAP21/WAS/LRRK2/ARHGAP5/SWAP70/WASL/RANGRF/RALGPS2/NUCB2/RGS10/RAPGEF1/ACAP2/EIF5/LAMTOR4/RABEP1/NCKAP1L/TAGAP/IQGAP1/RGS18/JUN/DOCK2/EPS8L1/AKAP13/CCDC88A/ARHGAP30/RIN3/ARHGAP26/IQGAP2/ARHGAP9	62
GO:0060589	nucleoside-triphosphatase regulator activity	62/2244	488/18367	0.390263967558051	0.770997401080477	HACD3/ADRB1/NET1/RASA1/ARHGAP23/NRP1/SYDE2/CHML/EPS8L2/DOCK9/ARHGDIB/DOCK1/OPHN1/ERRFI1/ARHGAP32/GPSM2/SH2D3A/SMAP2/NF1/RANBP1/VAV3/RAB3IP/ARHGAP10/CYTH3/RGS2/DEPDC1/FAM13A/ECT2/DENND4C/RHOD/GPSM3/ARF4/ARHGAP18/ARHGAP21/WAS/LRRK2/ARHGAP5/SWAP70/WASL/RANGRF/RALGPS2/NUCB2/RGS10/RAPGEF1/ACAP2/EIF5/LAMTOR4/RABEP1/NCKAP1L/TAGAP/IQGAP1/RGS18/JUN/DOCK2/EPS8L1/AKAP13/CCDC88A/ARHGAP30/RIN3/ARHGAP26/IQGAP2/ARHGAP9	62
GO:0002162	dystroglycan binding	2/2244	11/18367	0.396392465095159	0.770997401080477	DAG1/DMD	2
GO:0004954	prostanoid receptor activity	2/2244	11/18367	0.396392465095159	0.770997401080477	PPARG/HPGD	2
GO:0005049	nuclear export signal receptor activity	2/2244	11/18367	0.396392465095159	0.770997401080477	RAN/NUP214	2
GO:0008503	benzodiazepine receptor activity	2/2244	11/18367	0.396392465095159	0.770997401080477	GABRE/TSPO	2
GO:0015368	calcium:cation antiporter activity	2/2244	11/18367	0.396392465095159	0.770997401080477	SLC3A2/SLC8A1	2
GO:0016273	arginine N-methyltransferase activity	2/2244	11/18367	0.396392465095159	0.770997401080477	PRMT7/PRMT1	2
GO:0016274	protein-arginine N-methyltransferase activity	2/2244	11/18367	0.396392465095159	0.770997401080477	PRMT7/PRMT1	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/2244	11/18367	0.396392465095159	0.770997401080477	P4HB/PCYOX1	2
GO:0019107	myristoyltransferase activity	2/2244	11/18367	0.396392465095159	0.770997401080477	NMT1/HADHB	2
GO:0019855	calcium channel inhibitor activity	2/2244	11/18367	0.396392465095159	0.770997401080477	PACSIN3/PHPT1	2
GO:0022889	serine transmembrane transporter activity	2/2244	11/18367	0.396392465095159	0.770997401080477	SFXN1/SLC1A5	2
GO:0031996	thioesterase binding	2/2244	11/18367	0.396392465095159	0.770997401080477	TRAF4/CDC42	2
GO:0032404	mismatch repair complex binding	2/2244	11/18367	0.396392465095159	0.770997401080477	PCNA/MSH6	2
GO:0035673	oligopeptide transmembrane transporter activity	2/2244	11/18367	0.396392465095159	0.770997401080477	GJA1/SLC13A3	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/2244	11/18367	0.396392465095159	0.770997401080477	GLRX/TXN	2
GO:0047676	arachidonate-CoA ligase activity	2/2244	11/18367	0.396392465095159	0.770997401080477	SLC27A2/ACSL1	2
GO:0070513	death domain binding	2/2244	11/18367	0.396392465095159	0.770997401080477	MCL1/BCL2	2
GO:0140036	ubiquitin-dependent protein binding	2/2244	11/18367	0.396392465095159	0.770997401080477	LAPTM5/USP15	2
GO:1990459	transferrin receptor binding	2/2244	11/18367	0.396392465095159	0.770997401080477	SNX4/CD81	2
GO:0031406	carboxylic acid binding	23/2244	176/18367	0.398374680897285	0.773481460078446	NR2F2/GLDC/FCN1/FOLR1/S100A8/S100A9/PPARG/SLC19A1/GSTP1/ADH5/PSAP/TYMS/SLC1A3/THNSL2/SESN1/DHFR/GOT1/SIGLEC6/NDUFAB1/GOT2/OGFOD3/GLUL/GRHPR	23
GO:0030291	protein serine/threonine kinase inhibitor activity	5/2244	34/18367	0.40297430906665	0.779652234649233	CDKN1C/PKIB/HEXIM1/CDKN2A/HSPB1	5
GO:0035198	miRNA binding	5/2244	34/18367	0.40297430906665	0.779652234649233	KCNQ1OT1/NEAT1/SOX4/HNRNPA1/AGO2	5
GO:0004896	cytokine receptor activity	13/2244	97/18367	0.405605797703449	0.783361901550499	CD74/PRLR/CSF2RA/IL6ST/CD44/IFNGR2/IL10RB/CXCR4/IL10RA/CCR1/CCR2/CD4/IL17RA	13
GO:0019894	kinesin binding	6/2244	42/18367	0.408388104257567	0.785967983106229	ACTB/PRC1/CLSTN1/KIFAP3/SPAG9/KTN1	6
GO:0051539	4 iron, 4 sulfur cluster binding	6/2244	42/18367	0.408388104257567	0.785967983106229	NUBP2/NDUFV1/NDUFS8/NFU1/DPYD/CIAPIN1	6
GO:0000993	RNA polymerase II complex binding	7/2244	50/18367	0.412113307330196	0.791748332996891	SMYD2/BRD4/RTF1/WDR43/ZNF326/NCOA3/AGO2	7
GO:0000339	RNA cap binding	3/2244	19/18367	0.415024690049344	0.791794930407183	NCBP3/AGO2/EIF4A1	3
GO:0003746	translation elongation factor activity	3/2244	19/18367	0.415024690049344	0.791794930407183	TSFM/EEF1A1/TUFM	3
GO:0004129	cytochrome-c oxidase activity	3/2244	19/18367	0.415024690049344	0.791794930407183	CYB5A/COX6A1/COX5A	3
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	3/2244	19/18367	0.415024690049344	0.791794930407183	DHFR/BLVRB/PYCR2	3
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	11/2244	82/18367	0.419209630567152	0.795639175489968	SYT7/PHLDA3/SCIN/PARD3/SLC9A1/ANXA2/CAPG/COMMD1/EXOC1/MYO1G/SDCBP	11
GO:0015078	proton transmembrane transporter activity	17/2244	130/18367	0.421400013955693	0.795639175489968	ATP6V1C2/CYB5A/SLC25A4/ATP6V1B1/SLC25A3/SLC9A1/COX6A1/SLC25A5/UQCR10/SLC11A1/CYC1/COX5A/UQCRH/ATP6V0D1/UQCRC1/UQCRFS1/ATP6V0B	17
GO:0004709	MAP kinase kinase kinase activity	4/2244	27/18367	0.423567254773146	0.795639175489968	EGFR/MAP3K4/LRRK2/MAP3K13	4
GO:0008139	nuclear localization sequence binding	4/2244	27/18367	0.423567254773146	0.795639175489968	NFKBIA/NUP214/TNPO1/KPNA2	4
GO:0015491	cation:cation antiporter activity	4/2244	27/18367	0.423567254773146	0.795639175489968	SLC9A1/SLC11A1/SLC3A2/SLC8A1	4
GO:0045499	chemorepellent activity	4/2244	27/18367	0.423567254773146	0.795639175489968	DPP4/SEMA6A/SEMA6D/SEMA3F	4
GO:0051119	sugar transmembrane transporter activity	4/2244	27/18367	0.423567254773146	0.795639175489968	SLC2A1/SLC2A8/SLC5A3/SLC2A3	4
GO:0051393	alpha-actinin binding	4/2244	27/18367	0.423567254773146	0.795639175489968	DAG1/PDLIM1/PPARG/PALLD	4
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	4/2244	27/18367	0.423567254773146	0.795639175489968	ABCB1/ATP10D/ABCA1/TMEM30B	4
GO:0000175	3'-5'-exoribonuclease activity	5/2244	35/18367	0.428317538805725	0.803186906102359	REXO2/ERI3/EXOSC9/EXOSC7/EXOSC3	5
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	8/2244	59/18367	0.434202112823082	0.809026497005218	REXO2/FEN1/RAD1/ERI3/EXOSC9/EXOSC7/EXOSC3/APEX1	8
GO:0000340	RNA 7-methylguanosine cap binding	2/2244	12/18367	0.441019002013784	0.809026497005218	NCBP3/AGO2	2
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/2244	12/18367	0.441019002013784	0.809026497005218	RPS3/APEX1	2
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	2/2244	12/18367	0.441019002013784	0.809026497005218	AKR1B1/AKR7A2	2
GO:0004126	cytidine deaminase activity	2/2244	12/18367	0.441019002013784	0.809026497005218	APOBEC3A/CDA	2
GO:0004526	ribonuclease P activity	2/2244	12/18367	0.441019002013784	0.809026497005218	POP7/RPP30	2
GO:0004875	complement receptor activity	2/2244	12/18367	0.441019002013784	0.809026497005218	FPR1/C5AR1	2
GO:0005024	transforming growth factor beta-activated receptor activity	2/2244	12/18367	0.441019002013784	0.809026497005218	TGFBR3/LTBP1	2
GO:0005095	GTPase inhibitor activity	2/2244	12/18367	0.441019002013784	0.809026497005218	IQGAP1/IQGAP2	2
GO:0008174	mRNA methyltransferase activity	2/2244	12/18367	0.441019002013784	0.809026497005218	TRMT10C/RNMT	2
GO:0035256	G protein-coupled glutamate receptor binding	2/2244	12/18367	0.441019002013784	0.809026497005218	HOMER1/FYN	2
GO:0042975	peroxisome proliferator activated receptor binding	2/2244	12/18367	0.441019002013784	0.809026497005218	HMGA1/MDM2	2
GO:0045295	gamma-catenin binding	2/2244	12/18367	0.441019002013784	0.809026497005218	CDH1/DSC3	2
GO:0005201	extracellular matrix structural constituent	22/2244	172/18367	0.443458907667738	0.812144276646926	FBN1/COL14A1/FBN2/LAMB1/LAMA5/VWA1/FBLN1/EFEMP1/TINAGL1/LAMC1/FRAS1/LTBP1/COL4A2/FGL2/VCAN/COL21A1/COL4A1/MFAP5/LAMC2/TGFBI/EMILIN2/CD4	22
GO:0016500	protein-hormone receptor activity	3/2244	20/18367	0.44907557960094	0.812229253025469	LGR4/LGR5/IGF1R	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/2244	20/18367	0.44907557960094	0.812229253025469	CYB5A/COX6A1/COX5A	3
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	3/2244	20/18367	0.44907557960094	0.812229253025469	CDS1/AASDHPPT/CHPT1	3
GO:0030296	protein tyrosine kinase activator activity	3/2244	20/18367	0.44907557960094	0.812229253025469	CD24/ERBB3/PAK2	3
GO:0061608	nuclear import signal receptor activity	3/2244	20/18367	0.44907557960094	0.812229253025469	TNPO1/NUTF2/KPNA2	3
GO:0015171	amino acid transmembrane transporter activity	11/2244	84/18367	0.451871767023803	0.812229253025469	SLC38A1/SLC38A9/SLC16A2/SLC1A3/SLC7A2/SFXN1/SLC1A5/SLC43A2/SLC25A13/SLC7A7/SLC3A2	11
GO:0004629	phospholipase C activity	4/2244	28/18367	0.452155664667677	0.812229253025469	NOTUM/PDIA3/CCR1/PLCB2	4
GO:0008187	poly-pyrimidine tract binding	4/2244	28/18367	0.452155664667677	0.812229253025469	MSI2/RBMS3/PABPC1/PTBP1	4
GO:0070325	lipoprotein particle receptor binding	4/2244	28/18367	0.452155664667677	0.812229253025469	HSP90B1/LRPAP1/AP2M1/CLTC	4
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4/2244	28/18367	0.452155664667677	0.812229253025469	PHLDA3/PLEKHA5/COMMD1/SNX3	4
GO:0042805	actinin binding	5/2244	36/18367	0.453436141331684	0.812229253025469	DAG1/PDLIM1/CSRP2/PPARG/PALLD	5
GO:0016597	amino acid binding	7/2244	52/18367	0.453848084270502	0.812229253025469	GLDC/ASS1/SLC1A3/THNSL2/GOT2/GLUL/GCHFR	7
GO:0008375	acetylglucosaminyltransferase activity	6/2244	44/18367	0.453871041116329	0.812229253025469	EXTL2/B3GNT3/B4GAT1/HEXA/LFNG/HEXB	6
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	6/2244	44/18367	0.453871041116329	0.812229253025469	ALDH7A1/AKR1B1/ALDH1A3/ADH5/ALDH2/PDHA1	6
GO:0008017	microtubule binding	34/2244	271/18367	0.461877817812543	0.823869863642861	CENPF/S100A8/S100A9/KIFC3/RPS3/CNN3/HOOK2/CAPN6/DST/PRC1/MAP9/TPX2/BIRC5/EML2/CAMSAP2/KIF21A/KIF20B/CLIP1/SKA2/LRRK2/MAP7D3/LRPPRC/MX1/EML4/DRG1/EZR/SBDS/NUSAP1/KATNBL1/MX2/GABARAPL2/FNTA/KIF22/CCDC88A	34
GO:0030246	carbohydrate binding	34/2244	271/18367	0.461877817812543	0.823869863642861	COLEC12/LMAN1/AGL/GALNT11/FCN1/VCAN/HLA-DRA/LGALS1/BSG/RPIA/UGP2/SLC2A8/HLA-DRB1/GANAB/CALR/CHID1/MLEC/LGALS2/SLC2A3/SIGLEC6/CLEC12A/SELL/OGFOD3/LGALS9/CLEC7A/EMC7/GAA/CLEC2B/CD302/CLEC4E/ASGR1/CD93/GPCPD1/CLEC4A	34
GO:0046982	protein heterodimerization activity	41/2244	328/18367	0.462907361515134	0.824365869451464	TENM3/ADRB1/CYBA/ERBB3/CYBB/EPAS1/JAM3/P4HB/BHLHE41/ITGB1/NAE1/RAN/MCL1/CEBPB/CAV1/TOP2A/BCL2A1/NFYB/PHB/SMC3/LSM5/YWHAE/PEF1/CENPW/BCL2/TRMT112/CAV2/TAF11/RRAGA/GTF2A2/RRAGC/KRT10/SAE1/HEXA/TPM1/IRAK3/MEF2C/UBA2/SDCBP/NR4A1/PHB2	41
GO:0050661	NADP binding	7/2244	53/18367	0.474503328517837	0.842281798356095	HSD17B1/IDH1/DHFR/HIBADH/TM7SF2/DPYD/GRHPR	7
GO:1901505	carbohydrate derivative transmembrane transporter activity	7/2244	53/18367	0.474503328517837	0.842281798356095	SLC35B4/SLC19A1/SLC25A4/SLC29A1/SLC25A5/SLC29A3/SLC25A6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6/2244	45/18367	0.476319419679755	0.842349691023255	FEN1/POP7/RNASEH2A/AGO2/RPP30/APEX1	6
GO:0004033	aldo-keto reductase (NADP) activity	4/2244	29/18367	0.480263750615607	0.842349691023255	AKR1B1/DHRS3/RDH14/AKR7A2	4
GO:0035250	UDP-galactosyltransferase activity	4/2244	29/18367	0.480263750615607	0.842349691023255	B3GNT3/B4GALT4/B4GALT7/B4GALT1	4
GO:0005035	death receptor activity	2/2244	13/18367	0.483755975701596	0.842349691023255	TNFRSF1B/TNFRSF14	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/2244	13/18367	0.483755975701596	0.842349691023255	SLC26A2/SLC13A4	2
GO:0031404	chloride ion binding	2/2244	13/18367	0.483755975701596	0.842349691023255	TDG/CTSC	2
GO:0032036	myosin heavy chain binding	2/2244	13/18367	0.483755975701596	0.842349691023255	CORO1A/MYL12B	2
GO:0034236	protein kinase A catalytic subunit binding	2/2244	13/18367	0.483755975701596	0.842349691023255	EZR/CSK	2
GO:0070700	BMP receptor binding	2/2244	13/18367	0.483755975701596	0.842349691023255	BMP7/PYCARD	2
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	2/2244	13/18367	0.483755975701596	0.842349691023255	HSD17B1/HSD17B11	2
GO:0140035	ubiquitination-like modification-dependent protein binding	2/2244	13/18367	0.483755975701596	0.842349691023255	LAPTM5/USP15	2
GO:0140299	small molecule sensor activity	2/2244	13/18367	0.483755975701596	0.842349691023255	EFHD1/PARK7	2
GO:0043177	organic acid binding	17/2244	135/18367	0.486179972569276	0.845228890504747	NR2F2/GLDC/FOLR1/S100A8/S100A9/PPARG/SLC19A1/ASS1/TYMS/SLC1A3/THNSL2/ID3/DHFR/GOT2/OGFOD3/GLUL/GCHFR	17
GO:0004860	protein kinase inhibitor activity	9/2244	70/18367	0.489100873294219	0.848961484183162	CDKN1C/PKIB/GMFG/NPM1/PARVA/HEXIM1/CDKN2A/HSPB1/SOCS3	9
GO:0005096	GTPase activator activity	57/2244	462/18367	0.489972458359081	0.84913078486558	HACD3/ADRB1/NET1/RASA1/ARHGAP23/NRP1/SYDE2/CHML/EPS8L2/DOCK9/ARHGDIB/DOCK1/OPHN1/ERRFI1/ARHGAP32/SH2D3A/SMAP2/NF1/RANBP1/VAV3/RAB3IP/ARHGAP10/CYTH3/RGS2/DEPDC1/FAM13A/ECT2/DENND4C/RHOD/ARF4/ARHGAP18/ARHGAP21/LRRK2/ARHGAP5/SWAP70/RANGRF/RALGPS2/NUCB2/RGS10/RAPGEF1/ACAP2/LAMTOR4/RABEP1/NCKAP1L/TAGAP/IQGAP1/RGS18/JUN/DOCK2/EPS8L1/AKAP13/CCDC88A/ARHGAP30/RIN3/ARHGAP26/IQGAP2/ARHGAP9	57
GO:0004864	protein phosphatase inhibitor activity	6/2244	46/18367	0.498489061963125	0.862527604059224	PTN/PPP1R35/BOD1/PPP1R14B/SET/ENSA	6
GO:0022853	active ion transmembrane transporter activity	33/2244	267/18367	0.499855485619233	0.863183735674777	SLC26A2/SLC22A11/SLC38A1/SLC13A4/ATP6V1C2/SLC6A4/CYB5A/SLC13A3/SLC19A1/SLC25A4/SLC5A6/SLC12A4/SLC1A3/SLC25A3/SLC9A1/SLC5A3/COX6A1/SLC25A5/ATP2B1/UQCR10/SLC11A1/ATP13A3/CYC1/SLC12A9/SLC3A2/SLC25A1/COX5A/UQCRH/ATP6V0D1/UQCRC1/UQCRFS1/SLC8A1/SLC25A6	33
GO:0004520	endodeoxyribonuclease activity	5/2244	38/18367	0.502659325641971	0.863183735674777	RPS3/FEN1/RAD51C/RAD50/APEX1	5
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	5/2244	38/18367	0.502659325641971	0.863183735674777	REXO2/ERI3/EXOSC9/EXOSC7/EXOSC3	5
GO:0140303	intramembrane lipid transporter activity	5/2244	38/18367	0.502659325641971	0.863183735674777	ABCB1/ATP10D/ABCA1/TMEM30B/PLSCR1	5
GO:0004518	nuclease activity	26/2244	210/18367	0.502802558884396	0.863183735674777	RPS3/REXO2/FEN1/N4BP2/RAD51C/SAMHD1/RAD1/POP7/RCL1/NME1/G3BP1/RAD50/RNASEH2A/RNASET2/DDX1/SND1/AGO2/ERI3/EXOSC9/EXOSC7/EXOSC3/RPP30/PLSCR1/APEX1/RNASE6/RNASE2	26
GO:0005537	mannose binding	3/2244	22/18367	0.514513667876	0.878868237295033	LMAN1/BSG/CLEC4A	3
GO:0017075	syntaxin-1 binding	3/2244	22/18367	0.514513667876	0.878868237295033	SLC6A4/STXBP2/LRRK2	3
GO:0004519	endonuclease activity	16/2244	129/18367	0.514589590561866	0.878868237295033	RPS3/FEN1/N4BP2/RAD51C/POP7/RCL1/G3BP1/RAD50/RNASEH2A/RNASET2/SND1/AGO2/RPP30/APEX1/RNASE6/RNASE2	16
GO:0030170	pyridoxal phosphate binding	7/2244	55/18367	0.515143369718055	0.878868237295033	GLDC/THNSL2/OAT/GOT1/GOT2/PDXDC1/ALAS1	7
GO:0004527	exonuclease activity	10/2244	80/18367	0.520164582435209	0.882309136945681	REXO2/FEN1/RAD1/RAD50/DDX1/ERI3/EXOSC9/EXOSC7/EXOSC3/APEX1	10
GO:0005044	scavenger receptor activity	6/2244	47/18367	0.520323928808978	0.882309136945681	COLEC12/SCARA3/PRSS12/LGALS3BP/CD36/CD163	6
GO:0005313	L-glutamate transmembrane transporter activity	2/2244	14/18367	0.52439886717282	0.882309136945681	SLC1A3/SLC25A13	2
GO:0015373	anion:sodium symporter activity	2/2244	14/18367	0.52439886717282	0.882309136945681	SLC13A4/SLC6A4	2
GO:0015562	efflux transmembrane transporter activity	2/2244	14/18367	0.52439886717282	0.882309136945681	GJA1/ABCB1	2
GO:0032977	membrane insertase activity	2/2244	14/18367	0.52439886717282	0.882309136945681	EMC7/EMC6	2
GO:0035259	glucocorticoid receptor binding	2/2244	14/18367	0.52439886717282	0.882309136945681	CEBPB/NR4A1	2
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	2/2244	14/18367	0.52439886717282	0.882309136945681	HSD17B1/HSD17B11	2
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	2/2244	14/18367	0.52439886717282	0.882309136945681	P2RY6/P2RY13	2
GO:0001664	G protein-coupled receptor binding	36/2244	295/18367	0.530016365421825	0.890395027362545	ITGB4/RNF43/ADRB1/ZNRF3/WLS/FCN1/GNAS/HOMER1/GNA12/GNAI1/GNAI2/FPR1/S1PR2/GNA11/DVL3/FLNA/C1QBP/CCL3L3/NEDD4/STAT1/PHB/ARRB2/ADM/RALA/JAK2/CCL3/PSMC5/HSPA8/PTPN11/JAK1/SDCBP/CCR2/CCL4/FYN/HSPA1A/CKLF	36
GO:0016878	acid-thiol ligase activity	4/2244	31/18367	0.534629662842636	0.892004640746046	SLC27A2/ACSS1/SUCLG1/ACSL1	4
GO:0031210	phosphatidylcholine binding	4/2244	31/18367	0.534629662842636	0.892004640746046	NF1/ABCA1/VDAC1/VDAC2	4
GO:0030374	nuclear receptor coactivator activity	7/2244	56/18367	0.535040158259707	0.892004640746046	HMGA1/USP22/DCAF6/NCOA3/WDR77/TSG101/ACTN1	7
GO:0042054	histone methyltransferase activity	7/2244	56/18367	0.535040158259707	0.892004640746046	SMYD2/PRMT7/EZH2/PRMT1/EED/SUZ12/NTMT1	7
GO:0070279	vitamin B6 binding	7/2244	56/18367	0.535040158259707	0.892004640746046	GLDC/THNSL2/OAT/GOT1/GOT2/PDXDC1/ALAS1	7
GO:0048020	CCR chemokine receptor binding	6/2244	48/18367	0.54177325746996	0.892693004384728	CCL3L3/STAT1/CCL3/JAK1/CCR2/CCL4	6
GO:0035064	methylated histone binding	9/2244	73/18367	0.54184791144967	0.892693004384728	MORC4/CBX5/CBX4/NCAPD3/SPIN1/MSH6/ING2/SUZ12/PWP1	9
GO:0106306	protein serine phosphatase activity	9/2244	73/18367	0.54184791144967	0.892693004384728	DUSP9/DUSP1/DUSP14/CTDSPL/DUSP5/PHLPP1/DUSP6/PPM1G/PPP2CB	9
GO:0106307	protein threonine phosphatase activity	9/2244	73/18367	0.54184791144967	0.892693004384728	DUSP9/DUSP1/DUSP14/CTDSPL/DUSP5/PHLPP1/DUSP6/PPM1G/PPP2CB	9
GO:0140034	methylation-dependent protein binding	9/2244	73/18367	0.54184791144967	0.892693004384728	MORC4/CBX5/CBX4/NCAPD3/SPIN1/MSH6/ING2/SUZ12/PWP1	9
GO:0004722	protein serine/threonine phosphatase activity	12/2244	98/18367	0.542949260909409	0.892693004384728	DUSP9/DUSP1/DUSP14/CTDSPL/CAMK2G/DUSP5/PHLPP1/LRRK2/TIMM50/DUSP6/PPM1G/PPP2CB	12
GO:0004529	exodeoxyribonuclease activity	3/2244	23/18367	0.54563099970026	0.892693004384728	FEN1/RAD1/APEX1	3
GO:0016493	C-C chemokine receptor activity	3/2244	23/18367	0.54563099970026	0.892693004384728	CXCR4/CCR1/CCR2	3
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	3/2244	23/18367	0.54563099970026	0.892693004384728	FEN1/RAD1/APEX1	3
GO:0030215	semaphorin receptor binding	3/2244	23/18367	0.54563099970026	0.892693004384728	SEMA6A/SEMA6D/SEMA3F	3
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	3/2244	23/18367	0.54563099970026	0.892693004384728	OTUD7B/OPTN/TNFAIP3	3
GO:0030145	manganese ion binding	8/2244	65/18367	0.547741420438727	0.892693004384728	EXTL2/NUDT8/SOD2/FEN1/LAP3/B4GALT7/GLUL/B4GALT1	8
GO:0004532	exoribonuclease activity	5/2244	40/18367	0.550046836942157	0.892693004384728	REXO2/ERI3/EXOSC9/EXOSC7/EXOSC3	5
GO:1902936	phosphatidylinositol bisphosphate binding	13/2244	107/18367	0.552921973057424	0.892693004384728	SYT7/PHLDA3/SCIN/PARD3/PLEKHA5/SLC9A1/ANXA2/CAPG/COMMD1/EXOC1/SNX3/MYO1G/SDCBP	13
GO:0004536	deoxyribonuclease activity	7/2244	57/18367	0.554602142668026	0.892693004384728	RPS3/FEN1/RAD51C/RAD1/NME1/RAD50/APEX1	7
GO:0005548	phospholipid transporter activity	7/2244	57/18367	0.554602142668026	0.892693004384728	ABCB1/ABCA1/TRIAP1/TMEM30B/PLEKHA8/PLSCR1/OSBPL8	7
GO:0043175	RNA polymerase core enzyme binding	7/2244	57/18367	0.554602142668026	0.892693004384728	SMYD2/BRD4/RTF1/WDR43/ZNF326/NCOA3/AGO2	7
GO:0019210	kinase inhibitor activity	9/2244	74/18367	0.558975585407324	0.892693004384728	CDKN1C/PKIB/GMFG/NPM1/PARVA/HEXIM1/CDKN2A/HSPB1/SOCS3	9
GO:0001222	transcription corepressor binding	4/2244	32/18367	0.560719240735158	0.892693004384728	EZH2/STAT1/EED/SUZ12	4
GO:0001223	transcription coactivator binding	4/2244	32/18367	0.560719240735158	0.892693004384728	EPAS1/TFAM/VGLL4/RPL23	4
GO:0140658	ATP-dependent chromatin remodeler activity	4/2244	32/18367	0.560719240735158	0.892693004384728	HELLS/SMARCA1/SMARCA2/CHD7	4
GO:0019212	phosphatase inhibitor activity	6/2244	49/18367	0.562791566585376	0.892693004384728	PTN/PPP1R35/BOD1/PPP1R14B/SET/ENSA	6
GO:0004467	long-chain fatty acid-CoA ligase activity	2/2244	15/18367	0.562821287078602	0.892693004384728	SLC27A2/ACSL1	2
GO:0004549	tRNA-specific ribonuclease activity	2/2244	15/18367	0.562821287078602	0.892693004384728	POP7/RPP30	2
GO:0004953	icosanoid receptor activity	2/2244	15/18367	0.562821287078602	0.892693004384728	PPARG/HPGD	2
GO:0005161	platelet-derived growth factor receptor binding	2/2244	15/18367	0.562821287078602	0.892693004384728	LYN/ITGA5	2
GO:0016846	carbon-sulfur lyase activity	2/2244	15/18367	0.562821287078602	0.892693004384728	MGST3/GLO1	2
GO:0042809	vitamin D receptor binding	2/2244	15/18367	0.562821287078602	0.892693004384728	TAF11/MED16	2
GO:0042813	Wnt-activated receptor activity	2/2244	15/18367	0.562821287078602	0.892693004384728	LRP5/FZD6	2
GO:0047372	acylglycerol lipase activity	2/2244	15/18367	0.562821287078602	0.892693004384728	MGLL/ABHD12	2
GO:0051139	metal ion:proton antiporter activity	2/2244	15/18367	0.562821287078602	0.892693004384728	SLC9A1/SLC11A1	2
GO:0051371	muscle alpha-actinin binding	2/2244	15/18367	0.562821287078602	0.892693004384728	PDLIM1/PALLD	2
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	2/2244	15/18367	0.562821287078602	0.892693004384728	PYCARD/CASP1	2
GO:0016407	acetyltransferase activity	11/2244	91/18367	0.563120837770494	0.892693004384728	FASN/BRCA2/USP22/SAT1/CASD1/HAT1/ACAT2/NCOA3/SMARCE1/HGSNAT/NAA10	11
GO:0003707	steroid hormone receptor activity	3/2244	24/18367	0.575548385611883	0.911077314597743	ESRRG/ESRRA/PGRMC2	3
GO:0030165	PDZ domain binding	10/2244	84/18367	0.584931575515057	0.924596452939506	GJA1/CRIM1/TGFBR3/ADRB1/CADM1/GNG12/BAIAP2/PLEKHA1/ATP2B1/ERC1	10
GO:0031369	translation initiation factor binding	4/2244	33/18367	0.585990628974656	0.924937726597406	EIF2S2/POLR2G/EIF5/EIF4EBP1	4
GO:0036002	pre-mRNA binding	7/2244	59/18367	0.592585675962553	0.931997119827755	SLBP/HNRNPA1/SRSF2/CELF2/SF1/SNRPC/PTBP1	7
GO:0005283	amino acid:sodium symporter activity	2/2244	16/18367	0.598958951211092	0.931997119827755	SLC38A1/SLC1A3	2
GO:0005521	lamin binding	2/2244	16/18367	0.598958951211092	0.931997119827755	SUN1/BNIP3L	2
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	2/2244	16/18367	0.598958951211092	0.931997119827755	FEN1/APEX1	2
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	2/2244	16/18367	0.598958951211092	0.931997119827755	RAD51C/RNASE2	2
GO:0042577	lipid phosphatase activity	2/2244	16/18367	0.598958951211092	0.931997119827755	PLPP3/EPHX2	2
GO:0050135	NAD(P)+ nucleosidase activity	2/2244	16/18367	0.598958951211092	0.931997119827755	BST1/TLR2	2
GO:0050700	CARD domain binding	2/2244	16/18367	0.598958951211092	0.931997119827755	CARD16/CASP1	2
GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	2/2244	16/18367	0.598958951211092	0.931997119827755	BST1/TLR2	2
GO:0070402	NADPH binding	2/2244	16/18367	0.598958951211092	0.931997119827755	DHFR/GRHPR	2
GO:0050660	flavin adenine dinucleotide binding	10/2244	85/18367	0.600505072690765	0.932460719925112	DHCR24/CYBB/ACADVL/CYB5R1/ETFA/D2HGDH/ILVBL/ACADS/SQLE/DPYD	10
GO:0008080	N-acetyltransferase activity	8/2244	68/18367	0.600956908830496	0.932460719925112	BRCA2/USP22/SAT1/HAT1/NCOA3/SMARCE1/HGSNAT/NAA10	8
GO:0008266	poly(U) RNA binding	3/2244	25/18367	0.604198189973158	0.936165839548806	MSI2/RBMS3/PABPC1	3
GO:0016410	N-acyltransferase activity	11/2244	94/18367	0.608021860349899	0.940761609032213	TGM2/BRCA2/USP22/SAT1/NMT1/HAT1/NCOA3/SMARCE1/ALAS1/HGSNAT/NAA10	11
GO:0004180	carboxypeptidase activity	5/2244	43/18367	0.616702905750382	0.951263156359005	CTSZ/LAP3/BLMH/CPVL/SCPEP1	5
GO:0004879	nuclear receptor activity	6/2244	52/18367	0.622883293560018	0.951263156359005	NR2F2/NR2F6/PPARG/ESRRG/ESRRA/NR4A1	6
GO:0098531	ligand-activated transcription factor activity	6/2244	52/18367	0.622883293560018	0.951263156359005	NR2F2/NR2F6/PPARG/ESRRG/ESRRA/NR4A1	6
GO:1901682	sulfur compound transmembrane transporter activity	6/2244	52/18367	0.622883293560018	0.951263156359005	SLC26A2/GJA1/SLC13A4/SLC19A3/SLC13A3/SLC5A6	6
GO:0030971	receptor tyrosine kinase binding	9/2244	78/18367	0.624568322603114	0.951263156359005	PTPN14/PCNA/NCK2/PTPN1/DAZAP2/DOK2/CRK/PTPN11/FNTA	9
GO:0008168	methyltransferase activity	25/2244	214/18367	0.626400093359539	0.951263156359005	GCSH/DNMT1/SMYD2/COMT/LCMT1/TYMS/DNMT3A/PRMT7/EZH2/MTR/COMTD1/PRMT1/ICMT/EED/TYW3/FAM98B/TRMT112/MGMT/EMG1/TRMT10C/ARMT1/SUZ12/CIAPIN1/NTMT1/RNMT	25
GO:0001637	G protein-coupled chemoattractant receptor activity	3/2244	26/18367	0.631534506482482	0.951263156359005	CXCR4/CCR1/CCR2	3
GO:0004950	chemokine receptor activity	3/2244	26/18367	0.631534506482482	0.951263156359005	CXCR4/CCR1/CCR2	3
GO:0042974	retinoic acid receptor binding	3/2244	26/18367	0.631534506482482	0.951263156359005	PPARG/HMGA1/FUS	3
GO:0005149	interleukin-1 receptor binding	2/2244	17/18367	0.632796402772912	0.951263156359005	TRIP6/IL1B	2
GO:0008381	mechanosensitive ion channel activity	2/2244	17/18367	0.632796402772912	0.951263156359005	TMC5/TMEM150C	2
GO:0008525	phosphatidylcholine transporter activity	2/2244	17/18367	0.632796402772912	0.951263156359005	ABCB1/ABCA1	2
GO:0015095	magnesium ion transmembrane transporter activity	2/2244	17/18367	0.632796402772912	0.951263156359005	TUSC3/MRS2	2
GO:0015116	sulfate transmembrane transporter activity	2/2244	17/18367	0.632796402772912	0.951263156359005	SLC26A2/SLC13A4	2
GO:0031420	alkali metal ion binding	2/2244	17/18367	0.632796402772912	0.951263156359005	TDG/DRG1	2
GO:0034185	apolipoprotein binding	2/2244	17/18367	0.632796402772912	0.951263156359005	HSPD1/ABCA1	2
GO:0042625	ATPase-coupled ion transmembrane transporter activity	2/2244	17/18367	0.632796402772912	0.951263156359005	ATP6V1C2/ATP6V0D1	2
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	2/2244	17/18367	0.632796402772912	0.951263156359005	ATP6V1C2/ATP6V0D1	2
GO:0046961	proton-transporting ATPase activity, rotational mechanism	2/2244	17/18367	0.632796402772912	0.951263156359005	ATP6V1C2/ATP6V0D1	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/2244	17/18367	0.632796402772912	0.951263156359005	B3GNT3/C1GALT1	2
GO:0015291	secondary active transmembrane transporter activity	28/2244	240/18367	0.633067213095802	0.951263156359005	SLC26A2/SLC22A11/SLC38A1/SLC13A4/SLC6A4/SLC16A12/SLC16A4/SLC13A3/SLC19A1/SLC16A1/SLC25A4/SLC16A2/SLC5A6/SLC12A4/SLC1A3/SLC25A3/SLC9A1/SLC5A3/ANKH/SLC25A5/SLC11A1/SLC1A5/SLC12A9/SLC3A2/SLC25A1/SLC16A3/SLC8A1/SLC25A6	28
GO:0015298	solute:cation antiporter activity	4/2244	35/18367	0.633886387692282	0.951263156359005	SLC9A1/SLC11A1/SLC3A2/SLC8A1	4
GO:0004843	thiol-dependent deubiquitinase	13/2244	113/18367	0.634778651297333	0.95130079299614	USP27X/OTUD7B/PSMD14/USP14/USP22/USP15/DESI2/UCHL3/USP10/USP48/USP3/USP9X/TNFAIP3	13
GO:1990782	protein tyrosine kinase binding	12/2244	105/18367	0.642294062928612	0.961250459799027	PTPN14/ITGB1/HSP90AA1/PCNA/NCK2/PTPN1/DAZAP2/DOK2/CRK/PTPN11/FNTA/CD4	12
GO:0003774	cytoskeletal motor activity	13/2244	114/18367	0.647661866836974	0.966646350911784	MYH10/MYO1C/KIFC3/MYO7A/KIF21A/MYO1F/SMC3/KIF20B/MYL6B/MYO1G/DYNLRB1/KIF22/DYNC1I2	13
GO:0101005	deubiquitinase activity	13/2244	114/18367	0.647661866836974	0.966646350911784	USP27X/OTUD7B/PSMD14/USP14/USP22/USP15/DESI2/UCHL3/USP10/USP48/USP3/USP9X/TNFAIP3	13
GO:0016741	transferase activity, transferring one-carbon groups	26/2244	225/18367	0.650288815046435	0.969248410470026	GCSH/DNMT1/ATIC/SMYD2/COMT/LCMT1/TYMS/DNMT3A/PRMT7/EZH2/MTR/COMTD1/PRMT1/ICMT/EED/TYW3/FAM98B/TRMT112/MGMT/EMG1/TRMT10C/ARMT1/SUZ12/CIAPIN1/NTMT1/RNMT	26
GO:0004674	protein serine/threonine kinase activity	45/2244	386/18367	0.656133529951311	0.971143807872049	EGFR/TGFBR3/NRK/LTBP1/PLK2/AAK1/STK17A/CAMK2G/CDK6/MAST4/CDK7/CHEK1/BRD4/PRKCZ/CDK4/PRKDC/PRKCH/MAP3K4/CSNK1E/SRPK1/PBK/EIF2AK1/TLK1/PRKCI/VRK1/CDK1/PDPK1/LRRK2/LIMK2/MAPK9/CCL3/TOP1/SLK/STK17B/MAP3K13/EIF2AK4/ADCK2/IRAK3/SYK/CCND3/HTATIP2/AKAP13/PAK2/STK4/RPS6KA1	45
GO:0046906	tetrapyrrole binding	17/2244	149/18367	0.65613364982512	0.971143807872049	CYBA/CYBB/CYB5A/MTR/EIF2AK1/PGRMC2/MMAB/CYP2J2/CYB5B/JAK2/CYC1/PTGES2/BACH1/TBXAS1/HMOX1/CYP1B1/HEBP2	17
GO:0005484	SNAP receptor activity	4/2244	36/18367	0.656442668487356	0.971143807872049	GOSR1/VAMP8/STX11/STX10	4
GO:0016405	CoA-ligase activity	3/2244	27/18367	0.657530412946149	0.971143807872049	SLC27A2/ACSS1/ACSL1	3
GO:0035255	ionotropic glutamate receptor binding	3/2244	27/18367	0.657530412946149	0.971143807872049	GNAS/OPHN1/FUS	3
GO:0051959	dynein light intermediate chain binding	3/2244	27/18367	0.657530412946149	0.971143807872049	DYNLL2/HOOK2/CCDC88A	3
GO:0016779	nucleotidyltransferase activity	15/2244	132/18367	0.657757383089273	0.971143807872049	CDS1/UGP2/POLR2L/POLR2I/PCYT2/POLR2H/POLR2F/POLR2K/POLR2G/OAS2/CMAS/NUDT5/POLR3K/POLR2J/OAS1	15
GO:0043178	alcohol binding	10/2244	89/18367	0.659809834221113	0.97286476900613	TSPO/NPC2/ABCA1/CAV1/VDAC1/CD81/VDAC2/STARD4/RBP7/OSBPL8	10
GO:0004867	serine-type endopeptidase inhibitor activity	11/2244	98/18367	0.664193712512953	0.973028820695034	ITIH5/SPINT1/CRIM1/SERPINF1/SERPINH1/SPINT2/PEBP1/APP/SERPINA1/ANXA2/SERPINB1	11
GO:0004303	estradiol 17-beta-dehydrogenase activity	2/2244	18/18367	0.664356049863792	0.973028820695034	HSD17B1/HSD17B11	2
GO:0042834	peptidoglycan binding	2/2244	18/18367	0.664356049863792	0.973028820695034	TLR2/NLRP3	2
GO:0050811	GABA receptor binding	2/2244	18/18367	0.664356049863792	0.973028820695034	GABARAPL1/GABARAPL2	2
GO:0070122	isopeptidase activity	2/2244	18/18367	0.664356049863792	0.973028820695034	PSMD7/PSMD14	2
GO:0016757	glycosyltransferase activity	31/2244	270/18367	0.672714136981583	0.983956544358395	CHPF/EXTL2/AGL/QPRT/GALNT11/PARP1/TYMP/PNP/B3GNT3/B4GAT1/RPN2/FUT8/UMPS/MTAP/NAMPT/B4GALT4/GLT8D1/TMTC3/PARP2/ST3GAL4/GXYLT1/B4GALT7/OSTC/C1GALT1/HEXA/UPP1/PARP9/LFNG/B4GALT1/PARP14/HEXB	31
GO:0061980	regulatory RNA binding	5/2244	46/18367	0.677156590093042	0.986489075017811	KCNQ1OT1/NEAT1/SOX4/HNRNPA1/AGO2	5
GO:0005109	frizzled binding	4/2244	37/18367	0.678042627678605	0.986489075017811	RNF43/ZNRF3/DVL3/SDCBP	4
GO:0042056	chemoattractant activity	4/2244	37/18367	0.678042627678605	0.986489075017811	MIF/VEGFB/HMGB1/CCL3	4
GO:0071949	FAD binding	4/2244	37/18367	0.678042627678605	0.986489075017811	DHCR24/CYB5R1/D2HGDH/SQLE	4
GO:0033293	monocarboxylic acid binding	8/2244	73/18367	0.681979247487829	0.989876183684265	NR2F2/S100A8/S100A9/PPARG/GSTP1/ADH5/PSAP/NDUFAB1	8
GO:0017056	structural constituent of nuclear pore	3/2244	28/18367	0.682175382739566	0.989876183684265	NUP214/NUTF2/UPF3A	3
GO:0008242	omega peptidase activity	14/2244	126/18367	0.6884225864462	0.997572934819347	USP27X/GGH/OTUD7B/PSMD14/USP14/USP22/USP15/DESI2/UCHL3/USP10/USP48/USP3/USP9X/TNFAIP3	14
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/2244	19/18367	0.693689151018433	0.997572934819347	TGFBR3/LTBP1	2
GO:0005326	neurotransmitter transmembrane transporter activity	2/2244	19/18367	0.693689151018433	0.997572934819347	SLC6A4/SLC29A1	2
GO:0016918	retinal binding	2/2244	19/18367	0.693689151018433	0.997572934819347	OPN3/RBP7	2
GO:0015293	symporter activity	16/2244	144/18367	0.69549244046413	0.997572934819347	SLC38A1/SLC13A4/SLC6A4/SLC16A12/SLC16A4/SLC13A3/SLC16A1/SLC16A2/SLC5A6/SLC12A4/SLC1A3/SLC25A3/SLC5A3/SLC1A5/SLC12A9/SLC16A3	16
GO:0035254	glutamate receptor binding	5/2244	47/18367	0.695827145007812	0.997572934819347	GNAS/HOMER1/OPHN1/FUS/FYN	5
GO:0019905	syntaxin binding	8/2244	74/18367	0.696888782285467	0.997572934819347	SYT7/SLC6A4/ABCA1/TMED9/STXBP2/LRRK2/VAMP8/STX10	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3/2244	29/18367	0.705472878753869	0.997572934819347	DHFR/BLVRB/PYCR2	3
GO:0033612	receptor serine/threonine kinase binding	3/2244	29/18367	0.705472878753869	0.997572934819347	BMP7/PYCARD/MDM2	3
GO:0003823	antigen binding	19/2244	171/18367	0.705678313526107	0.997572934819347	DHCR24/HLA-B/HLA-A/HLA-C/FCN1/HLA-E/HLA-DRA/CD48/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-F/TSPAN4/TGFB1/ITGA4/HLA-DQB1/TAPBP/TAP1/CD1D	19
GO:0005085	guanyl-nucleotide exchange factor activity	25/2244	223/18367	0.707874503164099	0.997572934819347	ADRB1/NET1/EPS8L2/DOCK9/DOCK1/SH2D3A/VAV3/RAB3IP/CYTH3/ECT2/DENND4C/RHOD/ARF4/SWAP70/RANGRF/RALGPS2/NUCB2/RAPGEF1/LAMTOR4/TAGAP/DOCK2/EPS8L1/AKAP13/CCDC88A/RIN3	25
GO:0140098	catalytic activity, acting on RNA	44/2244	386/18367	0.712944878190797	0.997572934819347	REXO2/FEN1/SAMHD1/POLR2L/POLR2I/POP7/RCL1/IARS2/DDX3Y/POLR2H/MOV10/POLR2F/G3BP1/RNASEH2A/RNASET2/TYW3/DDX1/POLR2K/SND1/AGO2/ERI3/EMG1/DDX56/TRMT10C/RTCB/EXOSC9/DHX32/EXOSC7/POLR2G/EXOSC3/RPP30/EIF4A1/DDX24/DDX18/PTRHD1/DHX36/RNMT/POLR3K/DDX52/POLR2J/APEX1/DDX46/RNASE6/RNASE2	44
GO:0016879	ligase activity, forming carbon-nitrogen bonds	5/2244	48/18367	0.713740387744771	0.997572934819347	ASS1/RIMKLB/PAICS/GCLM/GLUL	5
GO:0004402	histone acetyltransferase activity	4/2244	39/18367	0.718340106023165	0.997572934819347	BRCA2/USP22/HAT1/NCOA3	4
GO:0004551	nucleotide diphosphatase activity	2/2244	20/18367	0.720868436731488	0.997572934819347	NUDT4/NUDT15	2
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	2/2244	20/18367	0.720868436731488	0.997572934819347	ATP6V1C2/ATP6V0D1	2
GO:0016408	C-acyltransferase activity	2/2244	20/18367	0.720868436731488	0.997572934819347	ACAT2/HADHB	2
GO:0031681	G-protein beta-subunit binding	2/2244	20/18367	0.720868436731488	0.997572934819347	GNG12/CCT5	2
GO:0035014	phosphatidylinositol 3-kinase regulator activity	2/2244	20/18367	0.720868436731488	0.997572934819347	KLF4/SOCS3	2
GO:0070300	phosphatidic acid binding	2/2244	20/18367	0.720868436731488	0.997572934819347	MICALL1/COMMD1	2
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	10/2244	94/18367	0.726342783989411	0.997572934819347	AGL/LYZ/FUCA1/GANAB/NAGLU/MAN1B1/GAA/HEXA/HEXB/HPSE	10
GO:0005343	organic acid:sodium symporter activity	3/2244	30/18367	0.727438144175044	0.997572934819347	SLC38A1/SLC13A3/SLC1A3	3
GO:0016417	S-acyltransferase activity	3/2244	30/18367	0.727438144175044	0.997572934819347	FASN/ZDHHC12/GLUL	3
GO:0017147	Wnt-protein binding	3/2244	30/18367	0.727438144175044	0.997572934819347	WLS/LRP5/FZD6	3
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/2244	10/18367	0.728401021686688	0.997572934819347	RAD50	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/2244	10/18367	0.728401021686688	0.997572934819347	AKAP13	1
GO:0005384	manganese ion transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC11A1	1
GO:0008190	eukaryotic initiation factor 4E binding	1/2244	10/18367	0.728401021686688	0.997572934819347	EIF4EBP1	1
GO:0008519	ammonium transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC12A4	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC35B4	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC3A2	1
GO:0015232	heme transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	PGRMC2	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/2244	10/18367	0.728401021686688	0.997572934819347	MAN1B1	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/2244	10/18367	0.728401021686688	0.997572934819347	CYB5R1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/2244	10/18367	0.728401021686688	0.997572934819347	DEGS1	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/2244	10/18367	0.728401021686688	0.997572934819347	ADH5	1
GO:0019531	oxalate transmembrane transporter activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC26A2	1
GO:0019869	chloride channel inhibitor activity	1/2244	10/18367	0.728401021686688	0.997572934819347	VAMP8	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/2244	10/18367	0.728401021686688	0.997572934819347	SLC27A2	1
GO:0035612	AP-2 adaptor complex binding	1/2244	10/18367	0.728401021686688	0.997572934819347	AAK1	1
GO:0048256	flap endonuclease activity	1/2244	10/18367	0.728401021686688	0.997572934819347	FEN1	1
GO:0097027	ubiquitin-protein transferase activator activity	1/2244	10/18367	0.728401021686688	0.997572934819347	UBE2L3	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/2244	10/18367	0.728401021686688	0.997572934819347	CASP1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/2244	10/18367	0.728401021686688	0.997572934819347	ADRB1	1
GO:0120016	sphingolipid transfer activity	1/2244	10/18367	0.728401021686688	0.997572934819347	PLEKHA8	1
GO:0034212	peptide N-acetyltransferase activity	5/2244	49/18367	0.73089366287652	0.999738588747559	BRCA2/USP22/HAT1/NCOA3/NAA10	5
GO:0020037	heme binding	15/2244	139/18367	0.734364572623838	0.999999999999843	CYBA/CYBB/CYB5A/EIF2AK1/PGRMC2/CYP2J2/CYB5B/JAK2/CYC1/PTGES2/BACH1/TBXAS1/HMOX1/CYP1B1/HEBP2	15
GO:0003925	G protein activity	4/2244	40/18367	0.737039358143278	0.999999999999843	HRAS/RHOA/RALA/CDC42	4
GO:0015144	carbohydrate transmembrane transporter activity	4/2244	40/18367	0.737039358143278	0.999999999999843	SLC2A1/SLC2A8/SLC5A3/SLC2A3	4
GO:0043014	alpha-tubulin binding	4/2244	40/18367	0.737039358143278	0.999999999999843	BEX4/EML4/FNTA/FYN	4
GO:0042562	hormone binding	9/2244	86/18367	0.738400699125605	0.999999999999843	LRP2/EGFR/TSPO/SLC40A1/PRLR/ALDH1A3/IGF1R/CALR/CTSH	9
GO:0004620	phospholipase activity	11/2244	104/18367	0.73918009960997	0.999999999999843	NOTUM/MGLL/PRDX6/PDIA3/ABHD12/LYPLAL1/CCR1/LYPLA1/PLCB2/HMOX1/PLBD1	11
GO:0001614	purinergic nucleotide receptor activity	2/2244	21/18367	0.745982102032211	0.999999999999843	P2RY6/P2RY13	2
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	2/2244	21/18367	0.745982102032211	0.999999999999843	LPCAT3/LPGAT1	2
GO:0005243	gap junction channel activity	2/2244	21/18367	0.745982102032211	0.999999999999843	GJA1/GJA5	2
GO:0016502	nucleotide receptor activity	2/2244	21/18367	0.745982102032211	0.999999999999843	P2RY6/P2RY13	2
GO:0051010	microtubule plus-end binding	2/2244	21/18367	0.745982102032211	0.999999999999843	DST/CLIP1	2
GO:0140359	ABC-type transporter activity	5/2244	50/18367	0.747288669647427	0.999999999999843	ABCB1/ABCA1/ATP13A3/TAPBP/TAP1	5
GO:0042910	xenobiotic transmembrane transporter activity	3/2244	31/18367	0.748096195746373	0.999999999999843	SLC2A1/ABCB1/SLC19A1	3
GO:0043015	gamma-tubulin binding	3/2244	31/18367	0.748096195746373	0.999999999999843	LYN/BRCA2/NME1	3
GO:0005253	anion channel activity	9/2244	87/18367	0.750818008171929	0.999999999999843	CLDN4/GABRE/FXYD3/CLIC3/VDAC1/VDAC2/VDAC3/CLIC4/CLIC1	9
GO:0003777	microtubule motor activity	7/2244	69/18367	0.754003917422951	0.999999999999843	KIFC3/KIF21A/SMC3/KIF20B/DYNLRB1/KIF22/DYNC1I2	7
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/2244	41/18367	0.754783957020801	0.999999999999843	COL14A1/COL4A2/COL21A1/COL4A1	4
GO:0061733	peptide-lysine-N-acetyltransferase activity	4/2244	41/18367	0.754783957020801	0.999999999999843	BRCA2/USP22/HAT1/NCOA3	4
GO:0004596	peptide alpha-N-acetyltransferase activity	1/2244	11/18367	0.761601877345841	0.999999999999843	NAA10	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/2244	11/18367	0.761601877345841	0.999999999999843	PKIB	1
GO:0015378	sodium:chloride symporter activity	1/2244	11/18367	0.761601877345841	0.999999999999843	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/2244	11/18367	0.761601877345841	0.999999999999843	SLC9A1	1
GO:0016832	aldehyde-lyase activity	1/2244	11/18367	0.761601877345841	0.999999999999843	ARMT1	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/2244	11/18367	0.761601877345841	0.999999999999843	GLCE	1
GO:0017128	phospholipid scramblase activity	1/2244	11/18367	0.761601877345841	0.999999999999843	PLSCR1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/2244	11/18367	0.761601877345841	0.999999999999843	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/2244	11/18367	0.761601877345841	0.999999999999843	DLG1	1
GO:0035197	siRNA binding	1/2244	11/18367	0.761601877345841	0.999999999999843	AGO2	1
GO:0035252	UDP-xylosyltransferase activity	1/2244	11/18367	0.761601877345841	0.999999999999843	GXYLT1	1
GO:0042285	xylosyltransferase activity	1/2244	11/18367	0.761601877345841	0.999999999999843	GXYLT1	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/2244	11/18367	0.761601877345841	0.999999999999843	SMYD2	1
GO:0048407	platelet-derived growth factor binding	1/2244	11/18367	0.761601877345841	0.999999999999843	COL4A1	1
GO:1901474	azole transmembrane transporter activity	1/2244	11/18367	0.761601877345841	0.999999999999843	SLC19A3	1
GO:0005506	iron ion binding	16/2244	151/18367	0.764654586358538	0.999999999999843	CDO1/FTL/FTH1/CALR/ADI1/RRM2/ETHE1/ISCU/NFU1/OGFOD3/CYP2J2/FDX1/FXN/TBXAS1/CYP1B1/ALOX5	16
GO:0031624	ubiquitin conjugating enzyme binding	3/2244	32/18367	0.767480018678568	0.999999999999843	SIAH1/SIAH2/DCUN1D5	3
GO:0005416	amino acid:cation symporter activity	2/2244	22/18367	0.769128945447832	0.999999999999843	SLC38A1/SLC1A3	2
GO:0015645	fatty acid ligase activity	2/2244	22/18367	0.769128945447832	0.999999999999843	SLC27A2/ACSL1	2
GO:0016881	acid-amino acid ligase activity	2/2244	22/18367	0.769128945447832	0.999999999999843	PAICS/GCLM	2
GO:0033691	sialic acid binding	2/2244	22/18367	0.769128945447832	0.999999999999843	FCN1/SIGLEC6	2
GO:0004175	endopeptidase activity	48/2244	430/18367	0.771110454167408	0.999999999999843	ADAMTS6/DPP4/MME/ADAMTS1/CTSL/CTSS/CTSV/ADAMTS19/PRSS8/LGMN/MMP15/PSMB5/PRSS12/PSMB1/MMP14/PYCARD/PSMB6/GPAA1/PSMB9/CFD/USP14/CTSZ/PDIA3/IMMP1L/PMPCA/USP15/PSMB7/CASP1/BACE2/PSMB8/PSMB2/BLMH/AFG3L2/CAPN1/CTSB/PMPCB/CTSD/PSMB4/TMEM59/MBTPS1/CTSH/USP10/CPNE1/USP48/UQCRC2/CTSC/USP9X/TPP1	48
GO:0019783	ubiquitin-like protein-specific protease activity	13/2244	125/18367	0.771897694855717	0.999999999999843	USP27X/OTUD7B/PSMD14/USP14/USP22/USP15/DESI2/UCHL3/USP10/USP48/USP3/USP9X/TNFAIP3	13
GO:0016791	phosphatase activity	30/2244	275/18367	0.773606646181199	0.999999999999843	PLPP3/DUSP9/PTPRF/PTPRC/DUSP1/DUSP14/PTPN14/EPHX2/CTDSPL/CAMK2G/DUSP5/UBASH3B/DLG1/ENOPH1/PHLPP1/PGP/ACP1/PTP4A1/LRRK2/PTPN6/PTPN1/HDDC2/TIMM50/PTP4A2/ARMT1/PTPN11/DUSP6/PPM1G/PPP2CB/PHPT1	30
GO:0015103	inorganic anion transmembrane transporter activity	16/2244	152/18367	0.773609243860448	0.999999999999843	SLC26A2/CLDN4/GABRE/SLC22A11/FXYD3/SLC13A4/SLC6A4/CLIC3/SLC12A4/ANKH/VDAC1/SLC12A9/VDAC2/VDAC3/CLIC4/CLIC1	16
GO:0015297	antiporter activity	9/2244	89/18367	0.774409561554794	0.999999999999843	SLC26A2/SLC19A1/SLC25A4/SLC9A1/SLC25A5/SLC11A1/SLC3A2/SLC8A1/SLC25A6	9
GO:0019888	protein phosphatase regulator activity	9/2244	89/18367	0.774409561554794	0.999999999999843	PTN/PPP2R2B/PPP1R35/BOD1/PPP1R14B/SET/ENSA/PPP4R2/PPP1R15A	9
GO:0005246	calcium channel regulator activity	4/2244	43/18367	0.787475060486781	0.999999999999843	TSPAN13/PACSIN3/YWHAE/PHPT1	4
GO:0015299	solute:proton antiporter activity	2/2244	23/18367	0.790414464090458	0.999999999999843	SLC9A1/SLC11A1	2
GO:0016849	phosphorus-oxygen lyase activity	2/2244	23/18367	0.790414464090458	0.999999999999843	RNASET2/BST1	2
GO:0042171	lysophosphatidic acid acyltransferase activity	2/2244	23/18367	0.790414464090458	0.999999999999843	LPCAT3/LPGAT1	2
GO:0071617	lysophospholipid acyltransferase activity	2/2244	23/18367	0.790414464090458	0.999999999999843	LPCAT3/LPGAT1	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/2244	12/18367	0.790745775103301	0.999999999999843	SLC35B4	1
GO:0008296	3'-5'-exodeoxyribonuclease activity	1/2244	12/18367	0.790745775103301	0.999999999999843	APEX1	1
GO:0015166	polyol transmembrane transporter activity	1/2244	12/18367	0.790745775103301	0.999999999999843	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/2244	12/18367	0.790745775103301	0.999999999999843	KCNN4	1
GO:0022858	alanine transmembrane transporter activity	1/2244	12/18367	0.790745775103301	0.999999999999843	SLC3A2	1
GO:0030955	potassium ion binding	1/2244	12/18367	0.790745775103301	0.999999999999843	DRG1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/2244	12/18367	0.790745775103301	0.999999999999843	P4HB	1
GO:0043176	amine binding	1/2244	12/18367	0.790745775103301	0.999999999999843	SLC6A4	1
GO:0051378	serotonin binding	1/2244	12/18367	0.790745775103301	0.999999999999843	SLC6A4	1
GO:0070410	co-SMAD binding	1/2244	12/18367	0.790745775103301	0.999999999999843	USP9X	1
GO:0089720	caspase binding	1/2244	12/18367	0.790745775103301	0.999999999999843	CARD16	1
GO:0005319	lipid transporter activity	16/2244	154/18367	0.790814202903618	0.999999999999843	SLC27A2/SLC2A1/ABCB1/TSPO/NPC2/ATP10D/ABCA1/TRIAP1/TMEM30B/PLEKHA8/CD36/OSBPL9/STARD4/PLSCR1/APOL3/OSBPL8	16
GO:0000049	tRNA binding	7/2244	72/18367	0.79221636760838	0.999999999999843	IARS2/MRPS27/ELP5/TRMT10C/EEF1A1/EIF2AK4/AIMP1	7
GO:0042379	chemokine receptor binding	7/2244	72/18367	0.79221636760838	0.999999999999843	CCL3L3/STAT1/CCL3/JAK1/CCR2/CCL4/CKLF	7
GO:0000149	SNARE binding	11/2244	110/18367	0.802126390653407	0.999999999999843	SYT7/SLC6A4/ABCA1/TMED9/TNFAIP2/STXBP2/LRRK2/GABARAPL2/VAMP8/STX11/STX10	11
GO:0008376	acetylgalactosaminyltransferase activity	3/2244	34/18367	0.802587295005724	0.999999999999843	CHPF/EXTL2/GALNT11	3
GO:0015370	solute:sodium symporter activity	7/2244	73/18367	0.803908183378742	0.999999999999843	SLC38A1/SLC13A4/SLC6A4/SLC13A3/SLC5A6/SLC1A3/SLC5A3	7
GO:0005544	calcium-dependent phospholipid binding	5/2244	54/18367	0.805447008673943	0.999999999999843	SYT7/ANXA3/ANXA5/ANXA2/CPNE1	5
GO:0008374	O-acyltransferase activity	5/2244	54/18367	0.805447008673943	0.999999999999843	LPCAT3/CPT2/PRDX6/CASD1/LPGAT1	5
GO:0051213	dioxygenase activity	9/2244	92/18367	0.806713314048131	0.999999999999843	CDO1/P4HB/ASPH/ADI1/PIR/KDM5B/ETHE1/OGFOD3/ALOX5	9
GO:0016874	ligase activity	17/2244	165/18367	0.807080571209295	0.999999999999843	SLC27A2/ACSS1/ASS1/RIMKLB/NAE1/LIG1/PAICS/GCLM/IARS2/MCCC2/SUCLG1/RTCB/GLUL/SAE1/UBA2/MDM2/ACSL1	17
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	2/2244	24/18367	0.809947743952147	0.999999999999843	BMP7/PYCARD	2
GO:0120014	phospholipid transfer activity	2/2244	24/18367	0.809947743952147	0.999999999999843	TRIAP1/PLEKHA8	2
GO:0002161	aminoacyl-tRNA editing activity	1/2244	13/18367	0.816328258386776	0.999999999999843	IARS2	1
GO:0004312	fatty acid synthase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	FASN	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/2244	13/18367	0.816328258386776	0.999999999999843	PPP1R14B	1
GO:0008179	adenylate cyclase binding	1/2244	13/18367	0.816328258386776	0.999999999999843	CAP1	1
GO:0008195	phosphatidate phosphatase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	PLPP3	1
GO:0008417	fucosyltransferase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	FUT8	1
GO:0008494	translation activator activity	1/2244	13/18367	0.816328258386776	0.999999999999843	PABPC1	1
GO:0009982	pseudouridine synthase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	TRUB2	1
GO:0015385	sodium:proton antiporter activity	1/2244	13/18367	0.816328258386776	0.999999999999843	SLC9A1	1
GO:0016423	tRNA (guanine) methyltransferase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	TRMT10C	1
GO:0016594	glycine binding	1/2244	13/18367	0.816328258386776	0.999999999999843	GLDC	1
GO:0022851	GABA-gated chloride ion channel activity	1/2244	13/18367	0.816328258386776	0.999999999999843	GABRE	1
GO:0039706	co-receptor binding	1/2244	13/18367	0.816328258386776	0.999999999999843	LRRK2	1
GO:0045159	myosin II binding	1/2244	13/18367	0.816328258386776	0.999999999999843	TRIOBP	1
GO:0045504	dynein heavy chain binding	1/2244	13/18367	0.816328258386776	0.999999999999843	DYNC1I2	1
GO:0051011	microtubule minus-end binding	1/2244	13/18367	0.816328258386776	0.999999999999843	CAMSAP2	1
GO:0061783	peptidoglycan muralytic activity	1/2244	13/18367	0.816328258386776	0.999999999999843	LYZ	1
GO:0072542	protein phosphatase activator activity	1/2244	13/18367	0.816328258386776	0.999999999999843	PPP1R15A	1
GO:0140333	glycerophospholipid flippase activity	1/2244	13/18367	0.816328258386776	0.999999999999843	ABCB1	1
GO:0005112	Notch binding	2/2244	25/18367	0.827839009515537	0.999999999999843	GALNT11/AAK1	2
GO:0016289	CoA hydrolase activity	2/2244	25/18367	0.827839009515537	0.999999999999843	HIBCH/PPT1	2
GO:0015294	solute:cation symporter activity	10/2244	104/18367	0.831866277284916	0.999999999999843	SLC38A1/SLC13A4/SLC6A4/SLC13A3/SLC5A6/SLC12A4/SLC1A3/SLC25A3/SLC5A3/SLC12A9	10
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	3/2244	36/18367	0.833126672028087	0.999999999999843	ATIC/APOBEC3A/CDA	3
GO:0004089	carbonate dehydratase activity	1/2244	14/18367	0.838784365403235	0.999999999999843	CA8	1
GO:0004707	MAP kinase activity	1/2244	14/18367	0.838784365403235	0.999999999999843	MAPK9	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/2244	14/18367	0.838784365403235	0.999999999999843	DOK2	1
GO:0005451	monovalent cation:proton antiporter activity	1/2244	14/18367	0.838784365403235	0.999999999999843	SLC9A1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/2244	14/18367	0.838784365403235	0.999999999999843	B3GNT3	1
GO:0019992	diacylglycerol binding	1/2244	14/18367	0.838784365403235	0.999999999999843	CHPT1	1
GO:0070411	I-SMAD binding	1/2244	14/18367	0.838784365403235	0.999999999999843	CTNNB1	1
GO:0140666	annealing activity	1/2244	14/18367	0.838784365403235	0.999999999999843	SMARCA1	1
GO:0042578	phosphoric ester hydrolase activity	39/2244	366/18367	0.842040527765849	0.999999999999843	PLPP3/DUSP9/PTPRF/NOTUM/PTPRC/DUSP1/DUSP14/PTPN14/EPHX2/CTDSPL/CAMK2G/DUSP5/SAMHD1/SMPDL3A/UBASH3B/DLG1/PDIA3/ENOPH1/PHLPP1/PGP/ACP1/PTP4A1/LRRK2/PTPN6/PTPN1/HDDC2/TIMM50/PTP4A2/ARMT1/PTPN11/DUSP6/PPM1G/PPP2CB/PHPT1/CCR1/GPCPD1/APEX1/PLCB2/HMOX1	39
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/2244	47/18367	0.842331880249373	0.999999999999843	ATP6V1C2/ATP2B1/ATP13A3/ATP6V0D1	4
GO:0004435	phosphatidylinositol phospholipase C activity	2/2244	26/18367	0.844197718101625	0.999999999999843	CCR1/PLCB2	2
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2/2244	26/18367	0.844197718101625	0.999999999999843	ZDHHC12/GLUL	2
GO:0019707	protein-cysteine S-acyltransferase activity	2/2244	26/18367	0.844197718101625	0.999999999999843	ZDHHC12/GLUL	2
GO:0016409	palmitoyltransferase activity	3/2244	37/18367	0.846810558294218	0.999999999999843	CPT2/ZDHHC12/GLUL	3
GO:0019208	phosphatase regulator activity	10/2244	107/18367	0.856533144573069	0.999999999999843	PTN/PPP2R2B/PPP1R35/ZEB2/BOD1/PPP1R14B/SET/ENSA/PPP4R2/PPP1R15A	10
GO:0004559	alpha-mannosidase activity	1/2244	15/18367	0.858496013854994	0.999999999999843	MAN1B1	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/2244	15/18367	0.858496013854994	0.999999999999843	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/2244	15/18367	0.858496013854994	0.999999999999843	SLC22A11	1
GO:0008020	G protein-coupled photoreceptor activity	1/2244	15/18367	0.858496013854994	0.999999999999843	OPN3	1
GO:0008559	ABC-type xenobiotic transporter activity	1/2244	15/18367	0.858496013854994	0.999999999999843	ABCB1	1
GO:0010851	cyclase regulator activity	1/2244	15/18367	0.858496013854994	0.999999999999843	GNAS	1
GO:0016805	dipeptidase activity	1/2244	15/18367	0.858496013854994	0.999999999999843	SCRN2	1
GO:0030280	structural constituent of skin epidermis	1/2244	15/18367	0.858496013854994	0.999999999999843	KRT10	1
GO:0030548	acetylcholine receptor regulator activity	1/2244	15/18367	0.858496013854994	0.999999999999843	FNTA	1
GO:0042043	neurexin family protein binding	1/2244	15/18367	0.858496013854994	0.999999999999843	SDCBP	1
GO:0045125	bioactive lipid receptor activity	1/2244	15/18367	0.858496013854994	0.999999999999843	S1PR2	1
GO:0048185	activin binding	1/2244	15/18367	0.858496013854994	0.999999999999843	TGFBR3	1
GO:0099602	neurotransmitter receptor regulator activity	1/2244	15/18367	0.858496013854994	0.999999999999843	FNTA	1
GO:0004190	aspartic-type endopeptidase activity	2/2244	27/18367	0.859131102514063	0.999999999999843	BACE2/CTSD	2
GO:0005501	retinoid binding	3/2244	38/18367	0.859507809805439	0.999999999999843	NR2F2/OPN3/RBP7	3
GO:0016251	RNA polymerase II general transcription initiation factor activity	3/2244	38/18367	0.859507809805439	0.999999999999843	TAF11/GTF2A2/GTF2H3	3
GO:0019840	isoprenoid binding	3/2244	38/18367	0.859507809805439	0.999999999999843	NR2F2/OPN3/RBP7	3
GO:0003730	mRNA 3'-UTR binding	20/2244	201/18367	0.864833420361584	0.999999999999843	IGF2BP3/RBMS3/PABPC1/ZFP36/RPL5/RPS7/ZFP36L2/EXOSC8/CIRBP/CARHSP1/FUS/KHSRP/HNRNPR/HNRNPA0/EXOSC9/CELF2/RNPS1/DHX36/SERBP1/CCT5	20
GO:0008009	chemokine activity	4/2244	49/18367	0.864966758425395	0.999999999999843	CCL3L3/CCL3/CCL4/CKLF	4
GO:0008081	phosphoric diester hydrolase activity	8/2244	89/18367	0.865769302442006	0.999999999999843	NOTUM/SMPDL3A/PDIA3/CCR1/GPCPD1/APEX1/PLCB2/HMOX1	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	15/2244	156/18367	0.870685394175754	0.999999999999843	DNMT1/SMYD2/COMT/LCMT1/DNMT3A/PRMT7/EZH2/COMTD1/PRMT1/ICMT/EED/EMG1/TRMT10C/ARMT1/RNMT	15
GO:0042626	ATPase-coupled transmembrane transporter activity	10/2244	109/18367	0.871321031410918	0.999999999999843	SLC26A2/ATP6V1C2/ABCB1/ABCA1/ATP2B1/ATP13A3/TAPBP/TAP1/ATP6V0D1/TOMM20	10
GO:0050681	androgen receptor binding	2/2244	28/18367	0.872743080958255	0.999999999999843	CALR/PARK7	2
GO:0070001	aspartic-type peptidase activity	2/2244	28/18367	0.872743080958255	0.999999999999843	BACE2/CTSD	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/2244	16/18367	0.875798484697921	0.999999999999843	CAPN1	1
GO:0005402	carbohydrate:cation symporter activity	1/2244	16/18367	0.875798484697921	0.999999999999843	SLC5A3	1
GO:0010181	FMN binding	1/2244	16/18367	0.875798484697921	0.999999999999843	NDUFV1	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/2244	16/18367	0.875798484697921	0.999999999999843	SLC22A11	1
GO:0015923	mannosidase activity	1/2244	16/18367	0.875798484697921	0.999999999999843	MAN1B1	1
GO:0016208	AMP binding	1/2244	16/18367	0.875798484697921	0.999999999999843	ACSS1	1
GO:0019841	retinol binding	1/2244	16/18367	0.875798484697921	0.999999999999843	RBP7	1
GO:0022821	potassium ion antiporter activity	1/2244	16/18367	0.875798484697921	0.999999999999843	SLC9A1	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/2244	16/18367	0.875798484697921	0.999999999999843	SOCS3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	6/2244	71/18367	0.879828799270072	0.999999999999843	TGM2/NIT2/HINT1/HINT2/ASAH1/VNN2	6
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	3/2244	40/18367	0.882155495416089	0.999999999999843	CYP2J2/HMOX1/CYP1B1	3
GO:0004222	metalloendopeptidase activity	10/2244	111/18367	0.884854404063405	0.999999999999843	ADAMTS6/MME/ADAMTS1/ADAMTS19/MMP15/MMP14/PMPCA/AFG3L2/PMPCB/UQCRC2	10
GO:0008235	metalloexopeptidase activity	6/2244	72/18367	0.887793565784771	0.999999999999843	ENPEP/TFRC/MMP15/MMP14/LAP3/METAP2	6
GO:0005005	transmembrane-ephrin receptor activity	1/2244	17/18367	0.890986114818234	0.999999999999843	EPHB4	1
GO:0008392	arachidonic acid epoxygenase activity	1/2244	17/18367	0.890986114818234	0.999999999999843	CYP2J2	1
GO:0008574	plus-end-directed microtubule motor activity	1/2244	17/18367	0.890986114818234	0.999999999999843	KIF20B	1
GO:0009881	photoreceptor activity	1/2244	17/18367	0.890986114818234	0.999999999999843	OPN3	1
GO:0015108	chloride transmembrane transporter activity	1/2244	17/18367	0.890986114818234	0.999999999999843	SLC26A2	1
GO:0015278	calcium-release channel activity	1/2244	17/18367	0.890986114818234	0.999999999999843	MCOLN3	1
GO:0016290	palmitoyl-CoA hydrolase activity	1/2244	17/18367	0.890986114818234	0.999999999999843	PPT1	1
GO:0016854	racemase and epimerase activity	1/2244	17/18367	0.890986114818234	0.999999999999843	GLCE	1
GO:0017081	chloride channel regulator activity	1/2244	17/18367	0.890986114818234	0.999999999999843	VAMP8	1
GO:0043395	heparan sulfate proteoglycan binding	1/2244	17/18367	0.890986114818234	0.999999999999843	PTPRC	1
GO:0016758	hexosyltransferase activity	19/2244	197/18367	0.891393252638494	0.999999999999843	CHPF/EXTL2/AGL/GALNT11/TYMP/B3GNT3/B4GAT1/RPN2/FUT8/MTAP/B4GALT4/TMTC3/B4GALT7/OSTC/C1GALT1/HEXA/LFNG/B4GALT1/HEXB	19
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/2244	30/18367	0.896397417887563	0.999999999999843	HSD17B1/HSD17B11	2
GO:0070566	adenylyltransferase activity	2/2244	30/18367	0.896397417887563	0.999999999999843	OAS2/OAS1	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	4/2244	53/18367	0.901964235426411	0.999999999999843	SLC6A4/SLC16A1/SLC5A3/SLC16A3	4
GO:0005254	chloride channel activity	6/2244	74/18367	0.902383605001098	0.999999999999843	CLDN4/GABRE/FXYD3/CLIC3/CLIC4/CLIC1	6
GO:0008083	growth factor activity	15/2244	162/18367	0.902926420209555	0.999999999999843	EFEMP1/BMP7/TYMP/PTN/GMFG/NENF/TIMP1/IGF2/VEGFB/MANF/MDK/GRN/TGFB1/RABEP1/CSH1	15
GO:0004708	MAP kinase kinase activity	1/2244	18/18367	0.904317295109672	0.999999999999843	PBK	1
GO:0008409	5'-3' exonuclease activity	1/2244	18/18367	0.904317295109672	0.999999999999843	FEN1	1
GO:0008569	minus-end-directed microtubule motor activity	1/2244	18/18367	0.904317295109672	0.999999999999843	KIFC3	1
GO:0016755	aminoacyltransferase activity	1/2244	18/18367	0.904317295109672	0.999999999999843	TGM2	1
GO:0099095	ligand-gated anion channel activity	1/2244	18/18367	0.904317295109672	0.999999999999843	GABRE	1
GO:1904047	S-adenosyl-L-methionine binding	1/2244	18/18367	0.904317295109672	0.999999999999843	PRMT1	1
GO:0016411	acylglycerol O-acyltransferase activity	2/2244	31/18367	0.906625088380059	0.999999999999843	LPCAT3/LPGAT1	2
GO:0018024	histone-lysine N-methyltransferase activity	3/2244	43/18367	0.910040849722848	0.999999999999843	SMYD2/EZH2/EED	3
GO:0030544	Hsp70 protein binding	3/2244	43/18367	0.910040849722848	0.999999999999843	RPS3/ST13/DNAJB9	3
GO:0008175	tRNA methyltransferase activity	2/2244	32/18367	0.915901426360158	0.999999999999843	TYW3/TRMT10C	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/2244	19/18367	0.916018858670296	0.999999999999843	GALNT11	1
GO:0004745	NAD-retinol dehydrogenase activity	1/2244	19/18367	0.916018858670296	0.999999999999843	DHRS3	1
GO:0004890	GABA-A receptor activity	1/2244	19/18367	0.916018858670296	0.999999999999843	GABRE	1
GO:0005003	ephrin receptor activity	1/2244	19/18367	0.916018858670296	0.999999999999843	EPHB4	1
GO:0030627	pre-mRNA 5'-splice site binding	1/2244	19/18367	0.916018858670296	0.999999999999843	SNRPC	1
GO:0035613	RNA stem-loop binding	1/2244	19/18367	0.916018858670296	0.999999999999843	MYH10	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	3/2244	44/18367	0.917912276193864	0.999999999999843	PBK/MAPK9/RPS6KA1	3
GO:0051879	Hsp90 protein binding	3/2244	44/18367	0.917912276193864	0.999999999999843	RPS3/AHSA1/GBP1	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	21/2244	222/18367	0.917986676382085	0.999999999999843	TGM2/LPCAT3/FASN/BRCA2/CPT2/PRDX6/USP22/SAT1/NMT1/ZDHHC12/CASD1/HAT1/ACAT2/NCOA3/SMARCE1/GLUL/ALAS1/HGSNAT/NAA10/HADHB/LPGAT1	21
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	46/2244	450/18367	0.919146304036353	0.999999999999843	TFDP2/PBX1/ISL1/TFAP2A/ZFAT/ZNF208/NFIB/TFCP2L1/GATA3/FOS/TFAP2C/EPAS1/TBX3/KLF5/DLX5/FOXO4/JUNB/ETV5/TP63/ESRRG/ELF3/KLF6/SPI1/GRHL1/SOX4/NFAT5/FOXC1/IRF6/IRF1/CEBPB/NFYB/ATMIN/MAFF/FOSB/CEBPD/CREB3L2/CREB3/KLF4/E2F4/MAFB/PLSCR1/MEF2C/BACH1/TFEC/NR4A1/JUN	46
GO:0052689	carboxylic ester hydrolase activity	13/2244	147/18367	0.921583802240489	0.999999999999843	NOTUM/PON2/PGAP1/MGLL/APMAP/IARS2/PRDX6/ABHD12/LYPLAL1/AOAH/PTRHD1/LYPLA1/PGLS	13
GO:0019239	deaminase activity	2/2244	33/18367	0.92430610176088	0.999999999999843	APOBEC3A/CDA	2
GO:0140223	general transcription initiation factor activity	3/2244	45/18367	0.925149971651177	0.999999999999843	TAF11/GTF2A2/GTF2H3	3
GO:0001972	retinoic acid binding	1/2244	20/18367	0.926289933509181	0.999999999999843	NR2F2	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/2244	20/18367	0.926289933509181	0.999999999999843	GLDC	1
GO:0019211	phosphatase activator activity	1/2244	20/18367	0.926289933509181	0.999999999999843	PPP1R15A	1
GO:0031418	L-ascorbic acid binding	1/2244	20/18367	0.926289933509181	0.999999999999843	OGFOD3	1
GO:0016298	lipase activity	11/2244	129/18367	0.92814576360029	0.999999999999843	NOTUM/MGLL/PRDX6/PDIA3/ABHD12/LYPLAL1/CCR1/LYPLA1/PLCB2/HMOX1/PLBD1	11
GO:0016782	transferase activity, transferring sulphur-containing groups	5/2244	68/18367	0.930120195492106	0.999999999999843	TSTD1/MOCS2/TPST2/CHST14/SULT1A1	5
GO:0015020	glucuronosyltransferase activity	2/2244	34/18367	0.931913527183078	0.999999999999843	CHPF/B4GAT1	2
GO:0016229	steroid dehydrogenase activity	2/2244	34/18367	0.931913527183078	0.999999999999843	HSD17B1/HSD17B11	2
GO:0045505	dynein intermediate chain binding	2/2244	34/18367	0.931913527183078	0.999999999999843	DYNLL2/DYNLRB1	2
GO:0001216	DNA-binding transcription activator activity	46/2244	456/18367	0.933436842129978	0.999999999999843	TFDP2/PBX1/ISL1/TFAP2A/ZFAT/ZNF208/NFIB/TFCP2L1/GATA3/FOS/TFAP2C/EPAS1/TBX3/KLF5/DLX5/FOXO4/JUNB/ETV5/TP63/ESRRG/ELF3/KLF6/SPI1/GRHL1/SOX4/NFAT5/FOXC1/IRF6/IRF1/CEBPB/NFYB/ATMIN/MAFF/FOSB/CEBPD/CREB3L2/CREB3/KLF4/E2F4/MAFB/PLSCR1/MEF2C/BACH1/TFEC/NR4A1/JUN	46
GO:0005123	death receptor binding	1/2244	21/18367	0.935305325083029	0.999999999999843	BID	1
GO:0008373	sialyltransferase activity	1/2244	21/18367	0.935305325083029	0.999999999999843	ST3GAL4	1
GO:0008391	arachidonic acid monooxygenase activity	1/2244	21/18367	0.935305325083029	0.999999999999843	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/2244	21/18367	0.935305325083029	0.999999999999843	ATP2B1	1
GO:0140358	P-type transmembrane transporter activity	1/2244	21/18367	0.935305325083029	0.999999999999843	ATP2B1	1
GO:0008649	rRNA methyltransferase activity	1/2244	22/18367	0.943218486018039	0.999999999999843	EMG1	1
GO:0009975	cyclase activity	1/2244	22/18367	0.943218486018039	0.999999999999843	BST1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/2244	22/18367	0.943218486018039	0.999999999999843	SLC26A2	1
GO:0016917	GABA receptor activity	1/2244	22/18367	0.943218486018039	0.999999999999843	GABRE	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/2244	22/18367	0.943218486018039	0.999999999999843	VCAN	1
GO:0050321	tau-protein kinase activity	1/2244	22/18367	0.943218486018039	0.999999999999843	FYN	1
GO:0140102	catalytic activity, acting on a rRNA	1/2244	22/18367	0.943218486018039	0.999999999999843	EMG1	1
GO:0008194	UDP-glycosyltransferase activity	12/2244	143/18367	0.943403204825137	0.999999999999843	CHPF/EXTL2/GALNT11/B3GNT3/B4GAT1/B4GALT4/GXYLT1/B4GALT7/HEXA/LFNG/B4GALT1/HEXB	12
GO:0070888	E-box binding	3/2244	48/18367	0.943489547276392	0.999999999999843	GATA3/PPARG/BHLHE41	3
GO:0005212	structural constituent of eye lens	1/2244	23/18367	0.950164123378383	0.999999999999843	VIM	1
GO:0047617	acyl-CoA hydrolase activity	1/2244	23/18367	0.950164123378383	0.999999999999843	PPT1	1
GO:0005125	cytokine activity	21/2244	235/18367	0.955082599526064	0.999999999999843	BMP7/CMTM8/FAM3B/TNFSF10/MIF/THNSL2/TNFSF13B/FAM3C/NAMPT/CCL3L3/TIMP1/GRN/HMGB1/SECTM1/CCL3/TGFB1/IL1B/TNF/AIMP1/CCL4/CKLF	21
GO:0008395	steroid hydroxylase activity	2/2244	38/18367	0.955681718615478	0.999999999999843	CYP2J2/CYP1B1	2
GO:0000030	mannosyltransferase activity	1/2244	24/18367	0.956260487701263	0.999999999999843	TMTC3	1
GO:0015295	solute:proton symporter activity	1/2244	24/18367	0.956260487701263	0.999999999999843	SLC25A3	1
GO:0106310	protein serine kinase activity	34/2244	360/18367	0.959680854655395	0.999999999999843	NRK/PLK2/AAK1/STK17A/CAMK2G/CDK6/MAST4/CDK7/CHEK1/PRKCZ/CDK4/PRKDC/PRKCH/MAP3K4/CSNK1E/SRPK1/PBK/EIF2AK1/TLK1/PRKCI/STK26/VRK1/CDK1/PDPK1/LRRK2/LIMK2/MAPK9/SLK/STK17B/MAP3K13/EIF2AK4/PAK2/STK4/RPS6KA1	34
GO:0019825	oxygen binding	2/2244	39/18367	0.960244417723307	0.999999999999843	SOD2/PARK7	2
GO:0008146	sulfotransferase activity	3/2244	52/18367	0.961493471557339	0.999999999999843	TPST2/CHST14/SULT1A1	3
GO:0017046	peptide hormone binding	3/2244	52/18367	0.961493471557339	0.999999999999843	SLC40A1/PRLR/IGF1R	3
GO:0005227	calcium activated cation channel activity	1/2244	25/18367	0.961611382625668	0.999999999999843	KCNN4	1
GO:0070330	aromatase activity	1/2244	25/18367	0.961611382625668	0.999999999999843	CYP1B1	1
GO:0008173	RNA methyltransferase activity	4/2244	65/18367	0.964985815422266	0.999999999999843	TYW3/EMG1/TRMT10C/RNMT	4
GO:0042923	neuropeptide binding	1/2244	26/18367	0.96630792920663	0.999999999999843	SORL1	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/2244	26/18367	0.96630792920663	0.999999999999843	SLC26A2	1
GO:0099604	ligand-gated calcium channel activity	1/2244	26/18367	0.96630792920663	0.999999999999843	MCOLN3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/2244	54/18367	0.968322849969818	0.999999999999843	P4HB/ASPH/KDM5B	3
GO:0004683	calmodulin-dependent protein kinase activity	1/2244	27/18367	0.970430114848652	0.999999999999843	CAMK2G	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	9/2244	125/18367	0.9752930831808	0.999999999999843	TGM2/ATIC/NIT2/HINT1/HINT2/APOBEC3A/CDA/ASAH1/VNN2	9
GO:0032452	histone demethylase activity	1/2244	29/18367	0.97722367767068	0.999999999999843	KDM5B	1
GO:0140457	protein demethylase activity	1/2244	29/18367	0.97722367767068	0.999999999999843	KDM5B	1
GO:0016746	acyltransferase activity	21/2244	250/18367	0.979026510822993	0.999999999999843	TGM2/LPCAT3/FASN/BRCA2/CPT2/PRDX6/USP22/SAT1/NMT1/ZDHHC12/CASD1/HAT1/ACAT2/NCOA3/SMARCE1/GLUL/ALAS1/HGSNAT/NAA10/HADHB/LPGAT1	21
GO:0008237	metallopeptidase activity	15/2244	190/18367	0.979071791763474	0.999999999999843	ADAMTS6/MME/ENPEP/ADAMTS1/ADAMTS19/TFRC/MMP15/MMP14/PSMD14/PMPCA/LAP3/METAP2/AFG3L2/PMPCB/UQCRC2	15
GO:0005217	intracellular ligand-gated ion channel activity	1/2244	30/18367	0.980010790076995	0.999999999999843	MCOLN3	1
GO:0016279	protein-lysine N-methyltransferase activity	3/2244	59/18367	0.980729297986295	0.999999999999843	SMYD2/EZH2/EED	3
GO:0016278	lysine N-methyltransferase activity	3/2244	60/18367	0.982577352335398	0.999999999999843	SMYD2/EZH2/EED	3
GO:0008170	N-methyltransferase activity	6/2244	97/18367	0.98346450801312	0.999999999999843	SMYD2/PRMT7/EZH2/PRMT1/EED/RNMT	6
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/2244	47/18367	0.983589317820589	0.999999999999843	ADRB1/GABRE	2
GO:0019787	ubiquitin-like protein transferase activity	42/2244	458/18367	0.984454607903003	0.999999999999843	RNF43/ZNRF3/LMO7/SIAH1/UBE2T/RNF128/AKTIP/KLHL42/TRIM28/ANAPC11/SIAH2/CBX4/UBE4B/KIAA1586/NEDD4/DTL/UBE2H/TRIM24/MYLIP/UBE2C/UBE2L6/RNF213/FBXO21/CCNB1IP1/UBE2N/RBX1/CDC34/UBE2S/FBXO22/CDC42/RNF130/TRIM22/WWP1/ZNF451/UBE2M/RNF149/MDM2/TNFAIP1/TRIM38/TNFAIP3/UBE2D3/UBE2L3	42
GO:0048019	receptor antagonist activity	1/2244	32/18367	0.984603933481088	0.999999999999843	LRPAP1	1
GO:0004623	phospholipase A2 activity	1/2244	33/18367	0.986488240722345	0.999999999999843	PRDX6	1
GO:0005251	delayed rectifier potassium channel activity	1/2244	33/18367	0.986488240722345	0.999999999999843	KCNG1	1
GO:0004842	ubiquitin-protein transferase activity	39/2244	433/18367	0.98654165923619	0.999999999999843	RNF43/ZNRF3/LMO7/SIAH1/UBE2T/RNF128/AKTIP/KLHL42/TRIM28/ANAPC11/SIAH2/UBE4B/NEDD4/DTL/UBE2H/TRIM24/MYLIP/UBE2C/UBE2L6/RNF213/FBXO21/CCNB1IP1/UBE2N/RBX1/CDC34/UBE2S/FBXO22/CDC42/RNF130/TRIM22/WWP1/UBE2M/RNF149/MDM2/TNFAIP1/TRIM38/TNFAIP3/UBE2D3/UBE2L3	39
GO:0004497	monooxygenase activity	6/2244	102/18367	0.989146568697073	0.999999999999843	PCBD1/CYP2J2/SQLE/TBXAS1/HMOX1/CYP1B1	6
GO:0008236	serine-type peptidase activity	14/2244	191/18367	0.98973120834221	0.999999999999843	DPP4/CTSS/CTSV/PRSS8/PRSS12/MMP14/CFD/IMMP1L/MBTPS1/CTSH/CPVL/SCPEP1/CTSC/TPP1	14
GO:0030551	cyclic nucleotide binding	1/2244	37/18367	0.991985298666328	0.999999999999843	SLC19A1	1
GO:0071855	neuropeptide receptor binding	1/2244	37/18367	0.991985298666328	0.999999999999843	GNAS	1
GO:0017171	serine hydrolase activity	14/2244	195/18367	0.992113423568686	0.999999999999843	DPP4/CTSS/CTSV/PRSS8/PRSS12/MMP14/CFD/IMMP1L/MBTPS1/CTSH/CPVL/SCPEP1/CTSC/TPP1	14
GO:0015081	sodium ion transmembrane transporter activity	10/2244	152/18367	0.992328535187731	0.999999999999843	SLC38A1/SLC13A4/SLC6A4/SLC13A3/SLC5A6/SLC1A3/SLC9A1/SLC5A3/SLC3A2/SLC8A1	10
GO:0004252	serine-type endopeptidase activity	12/2244	174/18367	0.992361559129167	0.999999999999843	DPP4/CTSS/CTSV/PRSS8/PRSS12/MMP14/CFD/IMMP1L/MBTPS1/CTSH/CTSC/TPP1	12
GO:0019213	deacetylase activity	1/2244	38/18367	0.99296647650554	0.999999999999843	OARD1	1
GO:0032451	demethylase activity	1/2244	39/18367	0.993827583315599	0.999999999999843	KDM5B	1
GO:0004812	aminoacyl-tRNA ligase activity	1/2244	41/18367	0.995246539308805	0.999999999999843	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/2244	41/18367	0.995246539308805	0.999999999999843	IARS2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	11/2244	170/18367	0.995399094845822	0.999999999999843	P4HB/DEGS1/ASPH/KDM5B/PCBD1/OGFOD3/CYP2J2/SQLE/TBXAS1/HMOX1/CYP1B1	11
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	24/2244	310/18367	0.9960225267049	0.999999999999843	PEG3/NFE2L3/NR2F6/TFAP2A/IRX2/GATA3/TFAP2C/ZNF439/TBX3/PPARG/BHLHE41/HIC2/ZNF440/SPI1/ZEB2/IFI16/CEBPB/CREM/ZFHX3/LRRFIP1/ETV7/BACH1/TFEC/JUN	24
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	1/2244	43/18367	0.996339407791152	0.999999999999843	SQLE	1
GO:0030547	signaling receptor inhibitor activity	1/2244	43/18367	0.996339407791152	0.999999999999843	LRPAP1	1
GO:0001217	DNA-binding transcription repressor activity	24/2244	313/18367	0.996661683371242	0.999999999999843	PEG3/NFE2L3/NR2F6/TFAP2A/IRX2/GATA3/TFAP2C/ZNF439/TBX3/PPARG/BHLHE41/HIC2/ZNF440/SPI1/ZEB2/IFI16/CEBPB/CREM/ZFHX3/LRRFIP1/ETV7/BACH1/TFEC/JUN	24
GO:0022839	ion gated channel activity	1/2244	44/18367	0.996787692495182	0.999999999999843	KCNN4	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/2244	44/18367	0.996787692495182	0.999999999999843	GABRE	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/2244	62/18367	0.997048118385365	0.999999999999843	ADRB1/GABRE	2
GO:0005245	voltage-gated calcium channel activity	1/2244	45/18367	0.997181100672927	0.999999999999843	ITGAV	1
GO:0061659	ubiquitin-like protein ligase activity	24/2244	316/18367	0.997203823873861	0.999999999999843	RNF43/ZNRF3/SIAH1/RNF128/ANAPC11/SIAH2/CBX4/UBE4B/KIAA1586/NEDD4/TRIM24/MYLIP/UBE2C/CCNB1IP1/RBX1/CDC42/RNF130/TRIM22/WWP1/ZNF451/RNF149/MDM2/TRIM38/UBE2D3	24
GO:0008528	G protein-coupled peptide receptor activity	8/2244	147/18367	0.998206463749865	0.999999999999843	LGR4/LGR5/FPR1/S1PR2/AGTRAP/CXCR4/CCR1/CCR2	8
GO:0030546	signaling receptor activator activity	41/2244	495/18367	0.998207112310447	0.999999999999843	FBN1/DPP4/EFEMP1/SEMA6A/BMP7/SEMA6D/CMTM8/APP/TYMP/PTN/FAM3B/GMFG/LRPAP1/TNFSF10/SEMA3F/MIF/THNSL2/TNFSF13B/NENF/FAM3C/NAMPT/CCL3L3/TIMP1/IGF2/VEGFB/MANF/MDK/GRN/INSL4/HMGB1/ADM/SECTM1/CCL3/TGFB1/IL1B/RABEP1/TNF/CSH1/AIMP1/CCL4/CKLF	41
GO:0015085	calcium ion transmembrane transporter activity	7/2244	135/18367	0.998242691446472	0.999999999999843	MCOLN3/ITGAV/TRPV6/ANXA2/ATP2B1/SLC3A2/SLC8A1	7
GO:0048018	receptor ligand activity	40/2244	487/18367	0.998370578435041	0.999999999999843	FBN1/DPP4/EFEMP1/SEMA6A/BMP7/SEMA6D/CMTM8/TYMP/PTN/FAM3B/GMFG/LRPAP1/TNFSF10/SEMA3F/MIF/THNSL2/TNFSF13B/NENF/FAM3C/NAMPT/CCL3L3/TIMP1/IGF2/VEGFB/MANF/MDK/GRN/INSL4/HMGB1/ADM/SECTM1/CCL3/TGFB1/IL1B/RABEP1/TNF/CSH1/AIMP1/CCL4/CKLF	40
GO:0140101	catalytic activity, acting on a tRNA	6/2244	124/18367	0.998477503006622	0.999999999999843	POP7/IARS2/TYW3/TRMT10C/RPP30/PTRHD1	6
GO:0008227	G protein-coupled amine receptor activity	1/2244	51/18367	0.998712981456691	0.999999999999843	ADRB1	1
GO:0001653	peptide receptor activity	8/2244	153/18367	0.998932339601401	0.999999999999843	LGR4/LGR5/FPR1/S1PR2/AGTRAP/CXCR4/CCR1/CCR2	8
GO:0061630	ubiquitin protein ligase activity	21/2244	304/18367	0.999183047734016	0.999999999999843	RNF43/ZNRF3/SIAH1/RNF128/ANAPC11/SIAH2/UBE4B/NEDD4/TRIM24/MYLIP/UBE2C/CCNB1IP1/RBX1/CDC42/RNF130/TRIM22/WWP1/RNF149/MDM2/TRIM38/UBE2D3	21
GO:0005179	hormone activity	5/2244	122/18367	0.99948588812187	0.999999999999843	FBN1/IGF2/INSL4/ADM/CSH1	5
GO:0034987	immunoglobulin receptor binding	2/2244	79/18367	0.999601918993811	0.999999999999843	FLNA/FGR	2
GO:0022824	transmitter-gated ion channel activity	1/2244	60/18367	0.999603156580509	0.999999999999843	GABRE	1
GO:0022835	transmitter-gated channel activity	1/2244	60/18367	0.999603156580509	0.999999999999843	GABRE	1
GO:0005262	calcium channel activity	4/2244	119/18367	0.999841167979318	0.999999999999843	MCOLN3/ITGAV/TRPV6/ANXA2	4
GO:0005244	voltage-gated ion channel activity	10/2244	201/18367	0.999860000562315	0.999999999999843	ITGAV/CYBB/KCNG1/CLIC3/VDAC1/TMEM109/VDAC2/VDAC3/CLIC4/CLIC1	10
GO:0022832	voltage-gated channel activity	10/2244	201/18367	0.999860000562315	0.999999999999843	ITGAV/CYBB/KCNG1/CLIC3/VDAC1/TMEM109/VDAC2/VDAC3/CLIC4/CLIC1	10
GO:0005230	extracellular ligand-gated ion channel activity	1/2244	73/18367	0.999927542429102	0.999999999999843	GABRE	1
GO:0030594	neurotransmitter receptor activity	3/2244	111/18367	0.999931948849692	0.999999999999843	ADRB1/GABRE/TSPO	3
GO:0015079	potassium ion transmembrane transporter activity	5/2244	155/18367	0.99998311364998	0.999999999999843	KCNN4/KCNG1/SLC12A4/SLC9A1/SLC12A9	5
GO:0046873	metal ion transmembrane transporter activity	27/2244	430/18367	0.99998729442173	0.999999999999843	TUSC3/KCNN4/SLC38A1/SLC13A4/MCOLN3/SLC6A4/ITGAV/SLC40A1/SLC39A10/KCNG1/SLC13A3/TRPV6/SLC5A6/SLC12A4/SLC39A1/SLC1A3/SLC9A1/SLC5A3/SLC30A5/SLC39A7/ANXA2/ATP2B1/SLC11A1/MRS2/SLC12A9/SLC3A2/SLC8A1	27
GO:0005249	voltage-gated potassium channel activity	1/2244	90/18367	0.999992175434456	0.999999999999843	KCNG1	1
GO:0005267	potassium channel activity	2/2244	121/18367	0.999997585676543	0.999999999999843	KCNN4/KCNG1	2
GO:0099094	ligand-gated cation channel activity	1/2244	113/18367	0.999999616164323	0.999999999999843	MCOLN3	1
GO:0022836	gated channel activity	15/2244	340/18367	0.999999834316857	0.999999999999843	GABRE/KCNN4/MCOLN3/TMC5/ITGAV/TMEM150C/CYBB/KCNG1/CLIC3/VDAC1/TMEM109/VDAC2/VDAC3/CLIC4/CLIC1	15
GO:0015276	ligand-gated ion channel activity	2/2244	143/18367	0.999999842400842	0.999999999999843	GABRE/MCOLN3	2
GO:0022834	ligand-gated channel activity	2/2244	143/18367	0.999999842400842	0.999999999999843	GABRE/MCOLN3	2
GO:0022843	voltage-gated cation channel activity	2/2244	143/18367	0.999999842400842	0.999999999999843	ITGAV/KCNG1	2
GO:0015267	channel activity	23/2244	480/18367	0.999999994453426	0.999999999999843	GJA1/CLDN4/GJA5/GABRE/KCNN4/FXYD3/MCOLN3/TMC5/ITGAV/TMEM150C/CYBB/KCNG1/CLIC3/TRPV6/ANXA2/VDAC1/TOMM40/BCL2/TMEM109/VDAC2/VDAC3/CLIC4/CLIC1	23
GO:0022803	passive transmembrane transporter activity	23/2244	481/18367	0.999999994915041	0.999999999999843	GJA1/CLDN4/GJA5/GABRE/KCNN4/FXYD3/MCOLN3/TMC5/ITGAV/TMEM150C/CYBB/KCNG1/CLIC3/TRPV6/ANXA2/VDAC1/TOMM40/BCL2/TMEM109/VDAC2/VDAC3/CLIC4/CLIC1	23
GO:0005216	ion channel activity	17/2244	432/18367	0.999999999638856	0.999999999999843	CLDN4/GABRE/KCNN4/FXYD3/MCOLN3/TMC5/ITGAV/TMEM150C/KCNG1/CLIC3/TRPV6/ANXA2/VDAC1/VDAC2/VDAC3/CLIC4/CLIC1	17
GO:0005261	cation channel activity	6/2244	335/18367	0.999999999999843	0.999999999999843	KCNN4/MCOLN3/ITGAV/KCNG1/TRPV6/ANXA2	6