ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	46/730	182/18367	1.88591305092607e-24	1.67657670227328e-21	RPLP0/RPL24/RPS13/RPL19/RPS3A/RPL23A/RPS21/RPL14/RPL18A/RPL8/RPS10/RPS6/RPL4/RPL6/RPLP1/RPL13/RPL29/RPS16/RPS12/RPS8/RPL15/RPS25/UBA52/RPS2/RPL28/RPL10/RPL26/RPS19/RPL9/RPL13A/RPS11/RPL32/RPS26/RPS5/RPL10A/RPL22/RPL3/RPL27A/RPS20/RPL12/RPL7A/RPL7/RPL17/RPL27/RPS4Y1/RPSA	46
GO:0045296	cadherin binding	53/730	332/18367	3.43081348073947e-18	1.52499659218869e-15	LDHA/ALDOA/PRDX6/ITGB1/RPL24/CD46/S100A11/RPL23A/KRT18/EIF4H/PKM/RPL14/KIF5B/HSPA8/ITGA6/EGFR/CDH1/RPL6/ARHGAP18/ANXA1/RPL29/KTN1/MACF1/RPL15/ARGLU1/CTNND1/RPS2/EZR/IDH1/EPS8L1/ENO1/HSPA5/RPS26/S100P/EFHD2/WASF2/LARP1/PKN2/PLEC/HSPA1A/DLG1/IQGAP1/FLNB/PHLDB2/PFN1/LRRFIP1/ERC1/RPL7A/RTN4/CLIC1/RAB1A/BZW2/CAPZB	53
GO:0019838	growth factor binding	22/730	141/18367	3.90763185831635e-08	1.15796157401441e-05	NRP2/ITGB4/HTRA4/LRP2/ITGAV/GLG1/TGFBR3/IGFBP3/ITGA6/DUSP1/EGFR/LIFR/RPS2/CRIM1/IL6ST/RPS19/LTBP1/GHR/SEC61B/ENG/FLT1/SDCBP	22
GO:0097718	disordered domain specific binding	10/730	36/18367	9.19647306806982e-07	0.000204391613937852	GAPDH/GJA1/CALM1/EZR/NCOA3/GJA5/CLTC/HSPA1A/MDM2/NUMA1	10
GO:0019843	rRNA binding	12/730	68/18367	1.33716221964583e-05	0.00201011998123047	RPLP0/RPS13/RPL19/RPL23A/RPL8/RPL9/NPM1/RPS11/RPS5/MDM2/RPL12/RPS4Y1	12
GO:0003712	transcription coregulator activity	40/730	489/18367	1.35666140465499e-05	0.00201011998123047	BASP1/TLE4/BRD4/KMT2C/FUS/SF1/MAGED1/BTG2/VGLL1/CBX4/SAP18/EDF1/DNMT3A/LPIN2/NPM1/N4BP2L2/TBL1X/ZNF451/BRD7/NCOA3/CCAR1/TLE1/PTPN14/ARID5B/MAML3/HSPA1A/USP22/TRIP11/RERE/DDX17/KDM5A/SERTAD2/RCOR1/EID1/TFAP2A/KDM5B/NCOA2/CDYL/HMGB1/SUB1	40
GO:0043021	ribonucleoprotein complex binding	18/730	149/18367	2.66134768037226e-05	0.00337991155407277	NEAT1/EIF4H/DDX5/RPLP1/NPM1/RPN2/HSPA5/CSNK2B/LARP1/MDM2/CCDC47/EIF1/CPEB4/SECISBP2L/SEC61B/EIF5A/SNRPD2/RPSA	18
GO:0045182	translation regulator activity	17/730	140/18367	4.13870381372098e-05	0.00459913461299744	EEF1A1/EIF4H/EEF1B2/NEURL1/RPL10/IGF2BP3/RPL22/LARP1/EIF2S2/EIF1/CPEB4/PURA/AGO2/EIF3H/EIF5A/EIF3I/PAIP2	17
GO:0003714	transcription corepressor activity	20/730	187/18367	5.73449329647876e-05	0.00499037101432764	BASP1/TLE4/SF1/BTG2/CBX4/SAP18/DNMT3A/N4BP2L2/TBL1X/ZNF451/BRD7/CCAR1/TLE1/HSPA1A/RERE/RCOR1/EID1/TFAP2A/KDM5B/CDYL	20
GO:0005178	integrin binding	17/730	144/18367	5.93538946701147e-05	0.00499037101432764	FBN1/ITGB1/FBLN1/ITGB4/IGF2/UTRN/ITGAV/PLPP3/LAMB1/EGFR/DST/LAMA5/JAM3/P4HB/HMGB1/PPIA/TIMP2	17
GO:0050840	extracellular matrix binding	10/730	56/18367	6.27978660653945e-05	0.00499037101432764	ITGB1/ADGRG1/DAG1/ITGAV/SMOC1/ITGA6/BCAM/TINAGL1/BGN/RPSA	10
GO:0048027	mRNA 5'-UTR binding	7/730	27/18367	6.73615884948613e-05	0.00499037101432764	RPS13/MYH10/RPS3A/RPL26/DHX36/IGF2BP3/LARP1	7
GO:0001968	fibronectin binding	7/730	28/18367	8.67549814419365e-05	0.00593270603860627	ITGB1/FBLN1/ITGAV/CCDC80/IGFBP3/FSTL3/CTSL	7
GO:0031994	insulin-like growth factor I binding	5/730	13/18367	9.64773224774913e-05	0.0061263099773207	ITGB4/LRP2/ITGAV/IGFBP3/ITGA6	5
GO:0005520	insulin-like growth factor binding	7/730	29/18367	0.000110464394278859	0.00654685643426035	ITGB4/HTRA4/LRP2/ITGAV/IGFBP3/ITGA6/CRIM1	7
GO:0003925	G protein activity	8/730	40/18367	0.000148950580984167	0.00827606665593279	RHOA/RALB/CDC42/HRAS/RAB11A/RAB1A/RAC1/ARL8B	8
GO:0140297	DNA-binding transcription factor binding	31/730	394/18367	0.000248221572073432	0.0129805280925459	ANXA4/FOS/TLE4/FUS/JUN/JUND/TACC2/DDX5/TBX3/ISL1/PARP1/RBPJ/NFE2L2/NPM1/HSPB1/NCOA3/BCL2/CEBPB/GTF2I/HMGN3/PURA/TDG/NEK6/HES1/NCOA2/CHD4/DDIT3/HMGB1/SRI/CHCHD2/CENPF	31
GO:0044325	transmembrane transporter binding	15/730	133/18367	0.000263962553922855	0.0130368172465232	TCAF1/AKAP9/CAV1/CALM1/PPP1R9A/PDE4B/HOMER1/USP10/HERPUD1/GOPC/DLG1/GRINA/VAMP2/SRI/PHPT1	15
GO:0035198	miRNA binding	7/730	34/18367	0.000320283962772204	0.014317413487381	NEAT1/KCNQ1OT1/SOX4/PUM1/HNRNPA1/AGO2/YBX1	7
GO:0090079	translation regulator activity, nucleic acid binding	13/730	108/18367	0.000353052540142264	0.014317413487381	EEF1A1/EIF4H/EEF1B2/LARP1/EIF2S2/EIF1/CPEB4/PURA/AGO2/EIF3H/EIF5A/EIF3I/PAIP2	13
GO:0005539	glycosaminoglycan binding	21/730	230/18367	0.000354311694850823	0.014317413487381	FBN1/NRP2/APLP2/ADGRG1/APP/SOD3/SMOC1/CCDC80/TGFBR3/EXTL2/RPL29/PGF/LRPAP1/GNS/BMP7/ADAMTS1/RPL22/BGN/PTPRF/ENG/PPIA	21
GO:0061134	peptidase regulator activity	21/730	230/18367	0.000354311694850823	0.014317413487381	GAPDH/SERPINB9/ITIH5/CAV1/FBLN1/SPINT1/APLP2/APP/CTSC/TFPI2/CRIM1/GPC3/ROCK1/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2	21
GO:0061980	regulatory RNA binding	8/730	46/18367	0.000409611710608477	0.0156608192899012	NEAT1/KCNQ1OT1/SOX4/DICER1/PUM1/HNRNPA1/AGO2/YBX1	8
GO:0047485	protein N-terminus binding	13/730	110/18367	0.000422789272168311	0.0156608192899012	RPS21/CALM1/PARP1/RBPJ/SRRM2/NPM1/NCOA3/HSPA1A/MDM2/NIPBL/EIF5A/GLRX/SDCBP	13
GO:0030414	peptidase inhibitor activity	18/730	187/18367	0.000488668532485903	0.0165764447308086	GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/APP/TFPI2/CRIM1/GPC3/ROCK1/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2	18
GO:0098631	cell adhesion mediator activity	9/730	59/18367	0.000498439956402119	0.0165764447308086	ITGB1/S100A11/KRT18/ANXA1/BCAM/JAM3/DSG2/DSC2/RPSA	9
GO:0004867	serine-type endopeptidase inhibitor activity	12/730	98/18367	0.000503446577876077	0.0165764447308086	SERPINB9/ITIH5/SPINT1/APLP2/APP/TFPI2/CRIM1/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1	12
GO:0008022	protein C-terminus binding	18/730	189/18367	0.000554894441039066	0.0176178985029904	FBLN1/PRRC2C/DST/BCAM/EZR/PPP1R9A/TBL1X/DLG1/GPSM2/NIPBL/SASH1/HRAS/POLR2A/AGO2/NUMA1/VAMP2/CENPF/SDCBP	18
GO:0043236	laminin binding	6/730	28/18367	0.000687317028425793	0.0210698220093286	ITGB1/DAG1/ITGA6/BCAM/TINAGL1/RPSA	6
GO:0048306	calcium-dependent protein binding	11/730	88/18367	0.000715651403442798	0.0212071365886882	ANXA4/S100A11/S100A9/DDX5/ANXA1/CALM1/PDCD6/S100P/SLC9A1/VAMP2/S100A6	11
GO:0003779	actin binding	32/730	440/18367	0.000778341612291632	0.0222196127278343	ALDOA/IQGAP2/ITGB1/MYH10/UTRN/SYNE2/DAG1/EGFR/DST/MACF1/TRIOBP/TMSB4X/EZR/RAI14/EPS8L1/PPP1R9A/SLC6A4/COBL/P4HB/DIAPH2/WASF2/CFL1/PLEC/IQGAP1/FLNB/ARPC3/PFN1/MTSS1/EPB41L3/TPM4/PDLIM2/CAPZB	32
GO:0003713	transcription coactivator activity	22/730	262/18367	0.000812217444012031	0.0222196127278343	BRD4/KMT2C/FUS/MAGED1/VGLL1/EDF1/LPIN2/NPM1/BRD7/NCOA3/CCAR1/ARID5B/MAML3/USP22/TRIP11/RERE/DDX17/KDM5A/SERTAD2/NCOA2/HMGB1/SUB1	22
GO:0001618	virus receptor activity	10/730	76/18367	0.000824800022518034	0.0222196127278343	ITGB1/CD46/TFRC/DAG1/ITGAV/EGFR/SLC52A1/HSPA1A/CD55/RPSA	10
GO:0004866	endopeptidase inhibitor activity	17/730	180/18367	0.000858790438837084	0.0224548441213579	GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/APP/TFPI2/CRIM1/ROCK1/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2	17
GO:0140272	exogenous protein binding	10/730	77/18367	0.000914819436226897	0.0232364136801632	ITGB1/CD46/TFRC/DAG1/ITGAV/EGFR/SLC52A1/HSPA1A/CD55/RPSA	10
GO:0008201	heparin binding	16/730	166/18367	0.000970184514725877	0.0233691031225	FBN1/NRP2/APLP2/ADGRG1/APP/SOD3/SMOC1/CCDC80/TGFBR3/RPL29/PGF/LRPAP1/BMP7/ADAMTS1/RPL22/PTPRF	16
GO:0002020	protease binding	14/730	135/18367	0.000972617340306523	0.0233691031225	SERPINB9/ITGB1/ADAMTSL4/LRP1/ITGAV/PSAP/BCL2/CLTC/CFLAR/RIPK2/SRI/SERPINE1/TIMP3/TIMP2	14
GO:0051082	unfolded protein binding	13/730	122/18367	0.0011344122022644	0.0265392749424487	NACA/HSPD1/HSPA8/LMAN1/HSP90B1/NPM1/HSPA5/AFG3L2/HSPA1A/SIL1/DNAJB4/SERPINH1/PPIA	13
GO:0072542	protein phosphatase activator activity	4/730	13/18367	0.00132761285378011	0.0302627647951415	IGFBP3/CALM1/B3GAT3/PPP1R15A	4
GO:0051020	GTPase binding	23/730	291/18367	0.00141158743544758	0.0313725307528226	IQGAP2/CAV1/TRIOBP/GOLGA4/ENO1/PPP1R9A/MYCBP2/DIAPH2/ROCK1/RAB11FIP1/PKN2/CHML/TRIP11/IQGAP1/TNPO1/PFN1/RANBP2/ERC1/KPNB1/RHOBTB3/RASA1/RAC1/YBX1	23
GO:0016853	isomerase activity	15/730	158/18367	0.00160612070378869	0.0348253976992231	CYP2J2/TPI1/MIF/ISYNA1/HSPD1/P4HB/NKTR/RPIA/PPIG/HSD3B1/GLCE/ERO1A/PDIA4/PGM2/PPIA	15
GO:0140678	molecular function inhibitor activity	13/730	128/18367	0.00176084226708954	0.035580494455011	ANXA4/DYNLL1/CAV1/ANXA1/CALM1/TXNIP/OAZ1/BCL2/RPS20/PURA/RASA1/DDIT3/PHPT1	13
GO:0008135	translation factor activity, RNA binding	10/730	84/18367	0.00179628852032633	0.035580494455011	EEF1A1/EIF4H/EEF1B2/EIF2S2/EIF1/CPEB4/AGO2/EIF3H/EIF5A/EIF3I	10
GO:0044548	S100 protein binding	4/730	14/18367	0.00180058783788826	0.035580494455011	S100A11/EZR/IQGAP1/S100A6	4
GO:0017134	fibroblast growth factor binding	5/730	23/18367	0.0018126172466131	0.035580494455011	ITGAV/GLG1/TGFBR3/RPS2/RPS19	5
GO:0031625	ubiquitin protein ligase binding	23/730	297/18367	0.00184106045548988	0.035580494455011	TPI1/PRDX6/JUN/HSPD1/HSPA8/EGFR/PSMD1/TRIOBP/TXNIP/UBA52/ABCB1/HSPA5/ACTG1/BCL2/HSPA1A/MDM2/RALB/POLR2A/NEK6/CDKN1A/RTN4/MAP1LC3B/UBE2A	23
GO:0044389	ubiquitin-like protein ligase binding	24/730	316/18367	0.0019203594215394	0.0360609483006704	TPI1/PRDX6/JUN/HSPD1/HSPA8/EGFR/PSMD1/TRIOBP/TXNIP/UBA52/ABCB1/HSPA5/ACTG1/BCL2/CEBPB/HSPA1A/MDM2/RALB/POLR2A/NEK6/CDKN1A/RTN4/MAP1LC3B/UBE2A	24
GO:0061135	endopeptidase regulator activity	17/730	194/18367	0.00194704782725779	0.0360609483006704	GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/APP/TFPI2/CRIM1/ROCK1/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2	17
GO:1901681	sulfur compound binding	21/730	265/18367	0.00216061718605252	0.0391997689469528	FBN1/NRP2/APLP2/LRP1/ADGRG1/APP/SOD3/SMOC1/CCDC80/TGFBR3/RPL29/PGF/DBI/LRPAP1/BMP7/ADAMTS1/RPL22/HADHA/CHST12/PTPRF/PPIA	21
GO:0003725	double-stranded RNA binding	9/730	74/18367	0.00258655431084364	0.0459889356467999	TFRC/EIF4H/HSPD1/DHX36/DICER1/CLTC/LRRFIP1/AGO2/HMGB1	9
GO:0016860	intramolecular oxidoreductase activity	7/730	51/18367	0.00384516425956655	0.0665610519731641	TPI1/MIF/P4HB/RPIA/HSD3B1/ERO1A/PDIA4	7
GO:0043024	ribosomal small subunit binding	4/730	17/18367	0.0038933348735709	0.0665610519731641	EIF4H/NPM1/LARP1/EIF1	4
GO:0008307	structural constituent of muscle	6/730	42/18367	0.0059764332581368	0.0983539362690261	KRT19/DAG1/MYL6/PLEC/ASPH/TPM4	6
GO:0015036	disulfide oxidoreductase activity	6/730	42/18367	0.0059764332581368	0.0983539362690261	P4HB/ERO1A/PDIA4/TXNRD1/GLRX/GSTO1	6
GO:0008330	protein tyrosine/threonine phosphatase activity	3/730	10/18367	0.00608488919549655	0.0983539362690261	DUSP1/DUSP6/DUSP9	3
GO:0048029	monosaccharide binding	8/730	71/18367	0.00701205791238191	0.110363813369043	ALDOA/UGP2/LMAN1/COLEC12/RPIA/MANBA/SLC2A8/ENG	8
GO:0016209	antioxidant activity	9/730	86/18367	0.00707619500791387	0.110363813369043	GPX3/PRDX6/SOD3/S100A9/GPX4/CAT/TXNRD1/GLRX/GSTO1	9
GO:0019211	phosphatase activator activity	4/730	20/18367	0.00721084684935579	0.110524876708229	IGFBP3/CALM1/B3GAT3/PPP1R15A	4
GO:0008509	anion transmembrane transporter activity	22/730	314/18367	0.00745298631119435	0.112300081875454	SLC26A2/CLIC3/FXYD3/GJA1/GABRE/SLC6A8/SLC16A12/SLC38A1/SLC13A4/SLC6A4/SLC52A3/CLDN4/SLC35B4/SLC52A1/SLC38A9/SLC9A1/MPC2/MFSD12/SLC2A8/CLIC1/SLC16A3/SLC7A5	22
GO:0003727	single-stranded RNA binding	9/730	87/18367	0.00762260555663498	0.112941605664142	EIF4H/MSI2/HNRNPDL/ANXA1/CBX4/L1TD1/HNRNPA1/AGO2/HMGB1	9
GO:0031267	small GTPase binding	19/730	259/18367	0.00777191283333132	0.113266073915271	IQGAP2/CAV1/TRIOBP/GOLGA4/MYCBP2/DIAPH2/ROCK1/RAB11FIP1/PKN2/CHML/TRIP11/IQGAP1/TNPO1/PFN1/RANBP2/ERC1/KPNB1/RHOBTB3/RAC1	19
GO:0061665	SUMO ligase activity	3/730	11/18367	0.00812185006742424	0.114608328729209	CBX4/ZNF451/RANBP2	3
GO:0097493	structural molecule activity conferring elasticity	3/730	11/18367	0.00812185006742424	0.114608328729209	FBN1/FBN2/LAMC1	3
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	21/730	299/18367	0.00857750689536448	0.119146931718422	ANXA4/FOS/FUS/JUN/JUND/TACC2/DDX5/TBX3/ISL1/PARP1/RBPJ/NFE2L2/NPM1/HSPB1/NCOA3/CEBPB/GTF2I/HMGN3/HES1/NCOA2/CHD4	21
GO:0005201	extracellular matrix structural constituent	14/730	172/18367	0.00885666967630733	0.120031091377899	FBN1/FBN2/COL14A1/FBLN1/LAMC1/LAMB1/EFEMP1/LAMA5/TFPI2/LTBP1/FRAS1/TINAGL1/BGN/COL4A2	14
GO:0042393	histone binding	18/730	244/18367	0.00891119463547957	0.120031091377899	MORC4/BRD4/KMT2C/CBX4/NASP/MPHOSPH8/CTSL/NPM1/BPTF/ATRX/TBL1X/BRD7/KDM5A/DEK/BRD2/BAZ1B/KDM5B/CDYL	18
GO:0003697	single-stranded DNA binding	11/730	123/18367	0.00992467421288665	0.131632929257878	HSPD1/ANXA1/DHX36/RAD50/HNRNPA1/RTF1/PURA/HMGB1/SUB1/SMARCA1/YBX1	11
GO:0016248	channel inhibitor activity	5/730	34/18367	0.0104641483812184	0.131632929257878	CAV1/CALM1/BCL2/RASA1/PHPT1	5
GO:0045505	dynein intermediate chain binding	5/730	34/18367	0.0104641483812184	0.131632929257878	DYNLL1/DYNC1H1/DYNLL2/HOOK3/DYNLRB1	5
GO:0000340	RNA 7-methylguanosine cap binding	3/730	12/18367	0.0105128661162085	0.131632929257878	NCBP3/LARP1/AGO2	3
GO:0005024	transforming growth factor beta-activated receptor activity	3/730	12/18367	0.0105128661162085	0.131632929257878	TGFBR3/LTBP1/ENG	3
GO:0015026	coreceptor activity	6/730	48/18367	0.0114464879050598	0.141332329827752	ITGB1/LRP1/ITGAV/TGFBR3/LRP5/ENG	6
GO:0019199	transmembrane receptor protein kinase activity	12/730	143/18367	0.0117645378091541	0.141394736174061	NRP2/TGFBR3/EPHB4/EGFR/EFEMP1/MET/CRIM1/LTBP1/BAZ1B/RIPK2/ENG/FLT1	12
GO:0009055	electron transfer activity	11/730	126/18367	0.0117696405814179	0.141394736174061	AKR1B1/GLDC/COX6A1/ADH5/ASPH/CYB5A/UQCRH/SDHA/CYP19A1/FDX1/CYBA	11
GO:0070412	R-SMAD binding	4/730	23/18367	0.011995427833579	0.142185804587356	FOS/JUN/DDX5/PARP1	4
GO:0098632	cell-cell adhesion mediator activity	6/730	49/18367	0.0126174407364493	0.147590852825045	S100A11/KRT18/ANXA1/JAM3/DSG2/DSC2	6
GO:0051015	actin filament binding	16/730	217/18367	0.0132330048267706	0.149311962308848	IQGAP2/MYH10/UTRN/SYNE2/EGFR/MACF1/TRIOBP/EZR/PPP1R9A/SLC6A4/CFL1/IQGAP1/FLNB/ARPC3/TPM4/CAPZB	16
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	3/730	13/18367	0.013268442094937	0.149311962308848	DUSP1/DUSP6/DUSP9	3
GO:0052650	NADP-retinol dehydrogenase activity	3/730	13/18367	0.013268442094937	0.149311962308848	AKR1B1/RDH10/RDH13	3
GO:0019789	SUMO transferase activity	4/730	24/18367	0.0139513889862302	0.151253473277544	CBX4/ZNF451/MDM2/RANBP2	4
GO:0050431	transforming growth factor beta binding	4/730	24/18367	0.0139513889862302	0.151253473277544	ITGAV/TGFBR3/LTBP1/ENG	4
GO:0070840	dynein complex binding	4/730	24/18367	0.0139513889862302	0.151253473277544	GPSM2/NUMA1/CENPF/DCTN6	4
GO:0017124	SH3 domain binding	11/730	130/18367	0.014622943283021	0.156624055163924	LRP2/ADAM12/GJA1/WASF2/FUT8/ZNF106/PTPN12/QKI/UVRAG/CYBA/CBLB	11
GO:0015035	protein-disulfide reductase activity	5/730	37/18367	0.0148737817642811	0.157414190338642	P4HB/ERO1A/PDIA4/TXNRD1/GLRX	5
GO:0003743	translation initiation factor activity	6/730	51/18367	0.0152065501546152	0.15904262455827	EIF4H/EIF2S2/EIF1/AGO2/EIF3H/EIF3I	6
GO:0043022	ribosome binding	7/730	66/18367	0.0155464145089064	0.160706540679276	RPN2/HSPA5/CCDC47/CPEB4/SEC61B/EIF5A/RPSA	7
GO:0008514	organic anion transmembrane transporter activity	14/730	185/18367	0.0160289989034389	0.163776161950907	SLC26A2/GJA1/SLC6A8/SLC16A12/SLC38A1/SLC52A3/SLC35B4/SLC52A1/SLC38A9/MPC2/MFSD12/SLC2A8/SLC16A3/SLC7A5	14
GO:0015926	glucosidase activity	3/730	14/18367	0.0163960387104957	0.163776161950907	AGL/GAA/GANAB	3
GO:0140666	annealing activity	3/730	14/18367	0.0163960387104957	0.163776161950907	EIF4H/ANXA1/SMARCA1	3
GO:0019903	protein phosphatase binding	12/730	150/18367	0.016664043376016	0.164603717347535	EGFR/KCNN4/MET/HSP90B1/PPP1R9A/BCL2/BOD1L1/GHR/SLC9A1/PPP6R2/IQGAP1/PPP1R15A	12
GO:0030165	PDZ domain binding	8/730	84/18367	0.0183947394258209	0.179702454390712	ATP2B1/TGFBR3/ADRB1/GJA1/CRIM1/GNG12/ERC1/GNG5	8
GO:0048185	activin binding	3/730	15/18367	0.0199003624869979	0.190230346784313	TGFBR3/FSTL3/ENG	3
GO:0050998	nitric-oxide synthase binding	3/730	15/18367	0.0199003624869979	0.190230346784313	CAV1/CALM1/SLC6A4	3
GO:0044183	protein folding chaperone	5/730	40/18367	0.0203798089300016	0.1927409589231	HSPA8/HSPB1/HSPA5/HSPA1A/CCDC47	5
GO:0051959	dynein light intermediate chain binding	4/730	27/18367	0.0209852846645338	0.196378084913375	DYNLL1/DYNC1H1/DYNLL2/HOOK3	4
GO:0060090	molecular adaptor activity	23/730	369/18367	0.0227460895044085	0.209999130472654	COL14A1/AKAP9/CAV1/DLG5/CUX1/SYNE2/HSPA8/DDB1/PDCD6/SKP1/HOMER1/SPAG9/RAD50/PDE4DIP/HERPUD1/SLC9A1/DLG1/IQGAP1/SASH1/EPB41L3/CDYL/VAMP2/SDCBP	23
GO:0019955	cytokine binding	11/730	139/18367	0.0229132909514595	0.209999130472654	CSF3R/NRP2/ITGB1/ITGAV/TGFBR3/LIFR/IL6ST/LTBP1/GHR/HMGB1/ENG	11
GO:0003785	actin monomer binding	4/730	28/18367	0.0237338624515041	0.211436514231502	TMSB4X/COBL/PFN1/MTSS1	4
GO:0070325	lipoprotein particle receptor binding	4/730	28/18367	0.0237338624515041	0.211436514231502	LRP1/HSP90B1/LRPAP1/CLTC	4
GO:0000900	translation repressor activity, mRNA regulatory element binding	3/730	16/18367	0.0237836348966819	0.211436514231502	CPEB4/PURA/PAIP2	3
GO:0001046	core promoter sequence-specific DNA binding	5/730	42/18367	0.0247041538755952	0.213215981649132	FOS/NPM1/CEBPB/NR3C1/AGO2	5
GO:0019902	phosphatase binding	14/730	196/18367	0.0250110887217659	0.213215981649132	CTSC/EGFR/KCNN4/MET/HSP90B1/PPP1R9A/BCL2/BOD1L1/GHR/SLC9A1/DLG1/PPP6R2/IQGAP1/PPP1R15A	14
GO:0019888	protein phosphatase regulator activity	8/730	89/18367	0.0251293945926201	0.213215981649132	IGFBP3/CALM1/PPP1R10/BOD1L1/B3GAT3/PPP6R2/PPP1R15A/PPP1R14B	8
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	6/730	57/18367	0.0251298137403528	0.213215981649132	P4HB/ERO1A/PDIA4/TXNRD1/GLRX/GSTO1	6
GO:0035064	methylated histone binding	7/730	73/18367	0.025700903035936	0.213215981649132	MORC4/CBX4/MPHOSPH8/BPTF/ATRX/KDM5A/CDYL	7
GO:0070063	RNA polymerase binding	7/730	73/18367	0.025700903035936	0.213215981649132	BRD4/STOM/NCOA3/PKN2/PABPN1/RTF1/AGO2	7
GO:0140034	methylation-dependent protein binding	7/730	73/18367	0.025700903035936	0.213215981649132	MORC4/CBX4/MPHOSPH8/BPTF/ATRX/KDM5A/CDYL	7
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	10/730	124/18367	0.0260891309553283	0.213215981649132	LDHA/AKR1B1/DHRS2/IDH1/RDH10/ADH5/HSD3B1/HADHA/HSD17B1/RDH13	10
GO:0140030	modification-dependent protein binding	12/730	160/18367	0.0261423419569802	0.213215981649132	MORC4/BRD4/AGL/HSPD1/CBX4/MPHOSPH8/BPTF/ATRX/BRD7/KDM5A/BRD2/CDYL	12
GO:0051087	chaperone binding	9/730	107/18367	0.0266693584263433	0.215536905827447	LRP2/HSPD1/CTSC/HSPA8/GRN/HSPA5/DNAJB4/HES1/ERP29	9
GO:0030674	protein-macromolecule adaptor activity	19/730	296/18367	0.0278673500921025	0.223189857944857	COL14A1/CAV1/DLG5/CUX1/SYNE2/HSPA8/DDB1/PDCD6/SKP1/HOMER1/SPAG9/RAD50/HERPUD1/SLC9A1/IQGAP1/EPB41L3/CDYL/VAMP2/SDCBP	19
GO:0042826	histone deacetylase binding	10/730	127/18367	0.0301296475015285	0.237179303015141	PARP1/GLI3/DHX36/PKN2/CEBPB/HSPA1A/NIPBL/HES1/CHD4/RAC1	10
GO:0005516	calmodulin binding	14/730	201/18367	0.0301476504394949	0.237179303015141	ATP2B1/IQGAP2/MYH10/PNCK/EGFR/DDX5/KCNN4/EDF1/PHKB/CAMK2G/SLC9A1/IQGAP1/SYT7/VAMP2	14
GO:0008301	DNA binding, bending	3/730	18/18367	0.0326849661194029	0.248349870770505	HMGB3/TFAM/HMGB1	3
GO:0033549	MAP kinase phosphatase activity	3/730	18/18367	0.0326849661194029	0.248349870770505	DUSP1/DUSP6/DUSP9	3
GO:0098641	cadherin binding involved in cell-cell adhesion	3/730	18/18367	0.0326849661194029	0.248349870770505	S100A11/KRT18/ANXA1	3
GO:0098918	structural constituent of synapse	3/730	18/18367	0.0326849661194029	0.248349870770505	ACTG1/DLG1/ERC1	3
GO:0090482	vitamin transmembrane transporter activity	4/730	31/18367	0.0332372278565372	0.250405894614081	SLC19A3/SLC52A3/SLC52A1/SLC2A8	4
GO:1990841	promoter-specific chromatin binding	6/730	62/18367	0.0361213134122345	0.26984745902081	DDX5/ISL1/NIPBL/POLR2A/DNMT1/ZNF609	6
GO:0046332	SMAD binding	7/730	79/18367	0.0374080085188059	0.272461874661655	FOS/JUN/TGFBR3/DDX5/PARP1/PURA/USP9X	7
GO:0000339	RNA cap binding	3/730	19/18367	0.0376971997563369	0.272461874661655	NCBP3/LARP1/AGO2	3
GO:0003746	translation elongation factor activity	3/730	19/18367	0.0376971997563369	0.272461874661655	EEF1A1/EEF1B2/EIF5A	3
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	3/730	19/18367	0.0376971997563369	0.272461874661655	TGFBR3/LTBP1/ENG	3
GO:0008200	ion channel inhibitor activity	4/730	33/18367	0.0406392853037677	0.29135745673427	CAV1/CALM1/RASA1/PHPT1	4
GO:0003756	protein disulfide isomerase activity	3/730	20/18367	0.0430771443869806	0.301540010708864	P4HB/ERO1A/PDIA4	3
GO:0016018	cyclosporin A binding	3/730	20/18367	0.0430771443869806	0.301540010708864	NKTR/PPIG/PPIA	3
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	3/730	20/18367	0.0430771443869806	0.301540010708864	P4HB/ERO1A/PDIA4	3
GO:0030291	protein serine/threonine kinase inhibitor activity	4/730	34/18367	0.0446626368934409	0.309175618427374	HSPB1/PKIB/CDKN1A/CDKN1C	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	10/730	136/18367	0.0448635036863119	0.309175618427374	LDHA/AKR1B1/DHRS2/IDH1/RDH10/ADH5/HSD3B1/HADHA/HSD17B1/RDH13	10
GO:0004721	phosphoprotein phosphatase activity	12/730	174/18367	0.0452980219104541	0.309768780603028	DUSP1/CTDSPL/DUSP6/PTPRA/PHLPP1/DUSP9/PTPN14/CAMK2G/DLG1/PTPN12/PTPRF/PHPT1	12
GO:0002039	p53 binding	6/730	66/18367	0.0468406011353603	0.31787247640714	BRD4/HSPD1/PTTG1IP/BRD7/USP10/MDM2	6
GO:0051010	microtubule plus-end binding	3/730	21/18367	0.0488179935958699	0.323874599303943	CLIP1/DST/NUMA1	3
GO:0070577	lysine-acetylated histone binding	3/730	21/18367	0.0488179935958699	0.323874599303943	BRD4/BRD7/BRD2	3
GO:0140033	acetylation-dependent protein binding	3/730	21/18367	0.0488179935958699	0.323874599303943	BRD4/BRD7/BRD2	3
GO:0097110	scaffold protein binding	6/730	67/18367	0.0497969454630456	0.327922107530723	DYNLL1/KRT8/KRT18/IL6ST/PSAP/DYNLL2	6
GO:0008013	beta-catenin binding	7/730	85/18367	0.0521673838382117	0.334154642590454	DLG5/KANK1/GJA1/CDH1/GLI3/SKP1/TBL1X	7
GO:0042162	telomeric DNA binding	4/730	36/18367	0.0533522992866174	0.334154642590454	RAD50/HNRNPA1/PURA/UPF2	4
GO:0043394	proteoglycan binding	4/730	36/18367	0.0533522992866174	0.334154642590454	LRP1/CTSL/PTPRF/SDCBP	4
GO:1901682	sulfur compound transmembrane transporter activity	5/730	52/18367	0.0548390372538713	0.334154642590454	SLC26A2/SLC19A3/GJA1/SLC13A4/MFSD12	5
GO:0004602	glutathione peroxidase activity	3/730	22/18367	0.0549117024394435	0.334154642590454	GPX3/PRDX6/GPX4	3
GO:0008106	alcohol dehydrogenase (NADP+) activity	3/730	22/18367	0.0549117024394435	0.334154642590454	AKR1B1/RDH10/RDH13	3
GO:0072349	modified amino acid transmembrane transporter activity	3/730	22/18367	0.0549117024394435	0.334154642590454	GJA1/SLC6A8/SLC16A12	3
GO:0005518	collagen binding	6/730	69/18367	0.0560461626106519	0.334154642590454	COL14A1/ITGB1/ADGRG1/CTSL/C1QTNF1/SERPINH1	6
GO:0004300	enoyl-CoA hydratase activity	2/730	10/18367	0.0574482006322778	0.334154642590454	HADHA/ECHDC2	2
GO:0008172	S-methyltransferase activity	2/730	10/18367	0.0574482006322778	0.334154642590454	DNMT3A/MTR	2
GO:0008239	dipeptidyl-peptidase activity	2/730	10/18367	0.0574482006322778	0.334154642590454	CTSC/DPP7	2
GO:0034511	U3 snoRNA binding	2/730	10/18367	0.0574482006322778	0.334154642590454	PRKDC/SNU13	2
GO:0045503	dynein light chain binding	2/730	10/18367	0.0574482006322778	0.334154642590454	GLUL/HOOK3	2
GO:0050786	RAGE receptor binding	2/730	10/18367	0.0574482006322778	0.334154642590454	S100A9/HMGB1	2
GO:0051880	G-quadruplex DNA binding	2/730	10/18367	0.0574482006322778	0.334154642590454	DHX36/RAD50	2
GO:0070567	cytidylyltransferase activity	2/730	10/18367	0.0574482006322778	0.334154642590454	NANS/CDS1	2
GO:0004714	transmembrane receptor protein tyrosine kinase activity	9/730	124/18367	0.0590071784641174	0.334154642590454	NRP2/EPHB4/EGFR/EFEMP1/MET/CRIM1/BAZ1B/RIPK2/FLT1	9
GO:0004857	enzyme inhibitor activity	6/730	70/18367	0.05933982846925	0.334154642590454	ANXA4/DYNLL1/ANXA1/TXNIP/OAZ1/RPS20	6
GO:0004860	protein kinase inhibitor activity	6/730	70/18367	0.05933982846925	0.334154642590454	NPM1/HSPB1/SOCS1/PKIB/CDKN1A/CDKN1C	6
GO:0046943	carboxylic acid transmembrane transporter activity	11/730	163/18367	0.060879477893144	0.334154642590454	SLC26A2/SLC16A12/SLC38A1/SLC27A2/ABCB1/SLC7A6/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5	11
GO:0030215	semaphorin receptor binding	3/730	23/18367	0.0613491436303232	0.334154642590454	SEMA6D/SEMA6A/SEMA4C	3
GO:0050750	low-density lipoprotein particle receptor binding	3/730	23/18367	0.0613491436303232	0.334154642590454	HSP90B1/LRPAP1/CLTC	3
GO:0016922	nuclear receptor binding	10/730	144/18367	0.0615134025504327	0.334154642590454	FUS/JUND/TACC2/DDX5/ISL1/PARP1/NCOA3/CEBPB/HMGN3/NCOA2	10
GO:0015459	potassium channel regulator activity	5/730	54/18367	0.0626325379099226	0.334154642590454	AKAP9/CAV1/DLG1/RASA1/SGK1	5
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	5/730	54/18367	0.0626325379099226	0.334154642590454	TET2/P4HB/KDM5A/ASPH/KDM5B	5
GO:0015175	neutral amino acid transmembrane transporter activity	4/730	38/18367	0.0628909294743928	0.334154642590454	SLC38A1/SLC38A9/MFSD12/SLC7A5	4
GO:0005342	organic acid transmembrane transporter activity	11/730	164/18367	0.0630373707830138	0.334154642590454	SLC26A2/SLC16A12/SLC38A1/SLC27A2/ABCB1/SLC7A6/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5	11
GO:0019208	phosphatase regulator activity	8/730	107/18367	0.063115647402129	0.334154642590454	IGFBP3/CALM1/PPP1R10/BOD1L1/B3GAT3/PPP6R2/PPP1R15A/PPP1R14B	8
GO:0051117	ATPase binding	7/730	89/18367	0.063786704556405	0.334154642590454	CAV1/EGFR/EZR/RALB/SNU13/RAC1/ATP6V1G1	7
GO:0016247	channel regulator activity	10/730	145/18367	0.0638418845242581	0.334154642590454	AKAP9/CAV1/FXYD3/CALM1/BCL2/DLG1/RASA1/SRI/PHPT1/SGK1	10
GO:0019887	protein kinase regulator activity	13/730	204/18367	0.0640710850594555	0.334154642590454	IGF2/RPLP1/CALM1/NPM1/HSPB1/SOCS1/CCNL1/PKIB/CSNK2B/IQGAP1/CDKN1A/CDKN1C/HMGB1	13
GO:0001965	G-protein alpha-subunit binding	3/730	24/18367	0.0681202514366222	0.334154642590454	NUCB2/GPSM2/SASH1	3
GO:0003707	steroid hormone receptor activity	3/730	24/18367	0.0681202514366222	0.334154642590454	ESRRA/NR3C1/ESRRG	3
GO:0043495	protein-membrane adaptor activity	3/730	24/18367	0.0681202514366222	0.334154642590454	SYNE2/PDCD6/EPB41L3	3
GO:0000774	adenyl-nucleotide exchange factor activity	2/730	11/18367	0.0684096118689119	0.334154642590454	SIL1/PFN1	2
GO:0002162	dystroglycan binding	2/730	11/18367	0.0684096118689119	0.334154642590454	DAG1/PLEC	2
GO:0005078	MAP-kinase scaffold activity	2/730	11/18367	0.0684096118689119	0.334154642590454	SPAG9/IQGAP1	2
GO:0005536	glucose binding	2/730	11/18367	0.0684096118689119	0.334154642590454	UGP2/SLC2A8	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/730	11/18367	0.0684096118689119	0.334154642590454	P4HB/ERO1A	2
GO:0019855	calcium channel inhibitor activity	2/730	11/18367	0.0684096118689119	0.334154642590454	CALM1/PHPT1	2
GO:0031996	thioesterase binding	2/730	11/18367	0.0684096118689119	0.334154642590454	CDC42/RAC1	2
GO:0035197	siRNA binding	2/730	11/18367	0.0684096118689119	0.334154642590454	DICER1/AGO2	2
GO:0043522	leucine zipper domain binding	2/730	11/18367	0.0684096118689119	0.334154642590454	ERC1/DDIT3	2
GO:0046975	histone methyltransferase activity (H3-K36 specific)	2/730	11/18367	0.0684096118689119	0.334154642590454	ASH1L/SETD2	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/730	11/18367	0.0684096118689119	0.334154642590454	TXNRD1/GLRX	2
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/730	11/18367	0.0684096118689119	0.334154642590454	DSG2/DSC2	2
GO:0099186	structural constituent of postsynapse	2/730	11/18367	0.0684096118689119	0.334154642590454	ACTG1/DLG1	2
GO:0051287	NAD binding	5/730	56/18367	0.0710173746836732	0.344996973190085	GAPDH/LDHA/PARP1/IDH1/HADHA	5
GO:0015631	tubulin binding	21/730	375/18367	0.072787691997388	0.35167531622651	GAPDH/ALDOA/DAG1/S100A9/CLIP1/KIF5B/GJA1/CAPN6/DST/MACF1/EZR/PDE4B/HOOK3/CEP350/NUMA1/SETD2/RAB11A/CCSAP/CENPF/MAP1LC3B/ARL8B	21
GO:0017022	myosin binding	6/730	74/18367	0.0736444374672185	0.351988736066437	FUS/TRIOBP/RHOA/MYL12B/VAMP2/RAB11A	6
GO:0019210	kinase inhibitor activity	6/730	74/18367	0.0736444374672185	0.351988736066437	NPM1/HSPB1/SOCS1/PKIB/CDKN1A/CDKN1C	6
GO:0008327	methyl-CpG binding	3/730	25/18367	0.0752141540964883	0.353785095194593	ZBTB38/DNMT1/MBD3	3
GO:0034237	protein kinase A regulatory subunit binding	3/730	25/18367	0.0752141540964883	0.353785095194593	AKAP9/EZR/WASF2	3
GO:0035035	histone acetyltransferase binding	3/730	25/18367	0.0752141540964883	0.353785095194593	GLI3/CEBPB/EID1	3
GO:0008234	cysteine-type peptidase activity	12/730	190/18367	0.0770505416939512	0.35914235528431	CTSC/USP27X/CTSL/CTSV/USP10/LGMN/USP22/USP48/USP9X/EIF3H/CFLAR/UCHL3	12
GO:0019003	GDP binding	6/730	75/18367	0.0775023575663986	0.35914235528431	RHOA/RHOB/RALB/HRAS/ARF1/ARL8B	6
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	2/730	12/18367	0.0799889610194526	0.35914235528431	CDKN1A/CDKN1C	2
GO:0005095	GTPase inhibitor activity	2/730	12/18367	0.0799889610194526	0.35914235528431	IQGAP2/IQGAP1	2
GO:0017154	semaphorin receptor activity	2/730	12/18367	0.0799889610194526	0.35914235528431	NRP2/MET	2
GO:0017166	vinculin binding	2/730	12/18367	0.0799889610194526	0.35914235528431	UTRN/DAG1	2
GO:0035256	G protein-coupled glutamate receptor binding	2/730	12/18367	0.0799889610194526	0.35914235528431	CALM1/HOMER1	2
GO:0043047	single-stranded telomeric DNA binding	2/730	12/18367	0.0799889610194526	0.35914235528431	RAD50/HNRNPA1	2
GO:0045295	gamma-catenin binding	2/730	12/18367	0.0799889610194526	0.35914235528431	CDH1/DSC3	2
GO:0030371	translation repressor activity	3/730	26/18367	0.0826192955011961	0.36908820955057	CPEB4/PURA/PAIP2	3
GO:0036002	pre-mRNA binding	5/730	59/18367	0.0846881403965941	0.376438784062861	SF1/DDX5/TRA2B/HNRNPA1/SRSF6	5
GO:0004709	MAP kinase kinase kinase activity	3/730	27/18367	0.0903235468557789	0.382685272921417	MAP3K4/EGFR/RIPK2	3
GO:0023026	MHC class II protein complex binding	3/730	27/18367	0.0903235468557789	0.382685272921417	PKM/HSPA8/B2M	3
GO:0045499	chemorepellent activity	3/730	27/18367	0.0903235468557789	0.382685272921417	SEMA6D/SEMA6A/SEMA4C	3
GO:0005246	calcium channel regulator activity	4/730	43/18367	0.0903258908073286	0.382685272921417	CALM1/SRI/PHPT1/SGK1	4
GO:0016504	peptidase activator activity	4/730	43/18367	0.0903258908073286	0.382685272921417	CAV1/FBLN1/APP/CTSC	4
GO:0004859	phospholipase inhibitor activity	2/730	13/18367	0.0921199644602735	0.382685272921417	ANXA4/ANXA1	2
GO:0008195	phosphatidate phosphatase activity	2/730	13/18367	0.0921199644602735	0.382685272921417	PLPP3/LPIN2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/730	13/18367	0.0921199644602735	0.382685272921417	SLC26A2/SLC13A4	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/730	13/18367	0.0921199644602735	0.382685272921417	TXNRD1/GLRX	2
GO:0031404	chloride ion binding	2/730	13/18367	0.0921199644602735	0.382685272921417	CTSC/TDG	2
GO:0042301	phosphate ion binding	2/730	13/18367	0.0921199644602735	0.382685272921417	PNP/GNG12	2
GO:0051011	microtubule minus-end binding	2/730	13/18367	0.0921199644602735	0.382685272921417	MACF1/NUMA1	2
GO:0060590	ATPase regulator activity	2/730	13/18367	0.0921199644602735	0.382685272921417	SIL1/PFN1	2
GO:0070700	BMP receptor binding	2/730	13/18367	0.0921199644602735	0.382685272921417	BMP7/GDF15	2
GO:0004713	protein tyrosine kinase activity	9/730	136/18367	0.0927165636654229	0.383372209760749	NRP2/EPHB4/EGFR/EFEMP1/MET/CRIM1/BAZ1B/RIPK2/FLT1	9
GO:0016835	carbon-oxygen lyase activity	6/730	79/18367	0.0940470841255592	0.387073415683436	TPI1/HACD3/ENO1/HADHA/ECHDC2/CDYL	6
GO:0043621	protein self-association	5/730	61/18367	0.0945152282569707	0.387207548020493	CTSC/PLEC/GPSM2/TDG/VAMP2	5
GO:1990756	ubiquitin ligase-substrate adaptor activity	3/730	28/18367	0.098314308984292	0.400923948105668	PDCD6/SKP1/HERPUD1	3
GO:0004197	cysteine-type endopeptidase activity	8/730	119/18367	0.101722607538262	0.412928758454407	CTSC/CTSL/CTSV/USP10/LGMN/USP48/USP9X/CFLAR	8
GO:0099106	ion channel regulator activity	9/730	139/18367	0.102605165143132	0.414618144601109	AKAP9/CAV1/FXYD3/CALM1/DLG1/RASA1/SRI/PHPT1/SGK1	9
GO:0015373	anion:sodium symporter activity	2/730	14/18367	0.104740618751903	0.417553408387632	SLC13A4/SLC6A4	2
GO:0015562	efflux transmembrane transporter activity	2/730	14/18367	0.104740618751903	0.417553408387632	GJA1/ABCB1	2
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	2/730	14/18367	0.104740618751903	0.417553408387632	MIF/HSD3B1	2
GO:0004033	aldo-keto reductase (NADP) activity	3/730	29/18367	0.106578605907214	0.41924062235183	AKR1B1/RDH10/RDH13	3
GO:0033612	receptor serine/threonine kinase binding	3/730	29/18367	0.106578605907214	0.41924062235183	BMP7/MDM2/GDF15	3
GO:0051787	misfolded protein binding	3/730	29/18367	0.106578605907214	0.41924062235183	HSPA8/HSPA5/HSPA1A	3
GO:0016836	hydro-lyase activity	5/730	64/18367	0.110288941957101	0.431924534801159	HACD3/ENO1/HADHA/ECHDC2/CDYL	5
GO:0004725	protein tyrosine phosphatase activity	7/730	102/18367	0.111537953716585	0.434900179184404	DUSP1/DUSP6/PTPRA/DUSP9/PTPN14/PTPN12/PTPRF	7
GO:0046966	thyroid hormone receptor binding	3/730	30/18367	0.115103170281087	0.446841564977671	FUS/NCOA3/HMGN3	3
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/730	47/18367	0.115723197805257	0.447295316734231	ATP2B1/ATP6V0E1/ATP13A3/ATP6V1G1	4
GO:0005041	low-density lipoprotein particle receptor activity	2/730	15/18367	0.117792965869581	0.449433247459474	LRP1/LRP2	2
GO:0071933	Arp2/3 complex binding	2/730	15/18367	0.117792965869581	0.449433247459474	IQGAP2/WASF2	2
GO:0098847	sequence-specific single stranded DNA binding	2/730	15/18367	0.117792965869581	0.449433247459474	RAD50/HNRNPA1	2
GO:0008017	microtubule binding	15/730	271/18367	0.12369178467582	0.467923389688529	GAPDH/S100A9/CLIP1/KIF5B/CAPN6/DST/MACF1/EZR/HOOK3/CEP350/NUMA1/RAB11A/CCSAP/CENPF/MAP1LC3B	15
GO:0030246	carbohydrate binding	15/730	271/18367	0.12369178467582	0.467923389688529	ALDOA/GALNT11/UGP2/SIGLEC6/AGL/LMAN1/GAA/COLEC12/GANAB/RPIA/GPCPD1/MANBA/SLC2A8/MLEC/ENG	15
GO:0005092	GDP-dissociation inhibitor activity	2/730	16/18367	0.131222870294281	0.482033103872286	CHML/GPSM2	2
GO:0005159	insulin-like growth factor receptor binding	2/730	16/18367	0.131222870294281	0.482033103872286	IGF2/SOCS1	2
GO:0008191	metalloendopeptidase inhibitor activity	2/730	16/18367	0.131222870294281	0.482033103872286	TIMP3/TIMP2	2
GO:0015923	mannosidase activity	2/730	16/18367	0.131222870294281	0.482033103872286	MAN1A2/MANBA	2
GO:0016307	phosphatidylinositol phosphate kinase activity	2/730	16/18367	0.131222870294281	0.482033103872286	PIP4K2A/PIK3CB	2
GO:0032183	SUMO binding	2/730	16/18367	0.131222870294281	0.482033103872286	CBX4/TDG	2
GO:1990380	Lys48-specific deubiquitinase activity	2/730	16/18367	0.131222870294281	0.482033103872286	USP27X/USP9X	2
GO:0030515	snoRNA binding	3/730	32/18367	0.13287903526634	0.482033103872286	PRKDC/SNU13/NOP10	3
GO:0140658	ATP-dependent chromatin remodeler activity	3/730	32/18367	0.13287903526634	0.482033103872286	ATRX/CHD4/SMARCA1	3
GO:0016791	phosphatase activity	15/730	275/18367	0.134771868371044	0.482033103872286	PLPP3/DUSP1/CTDSPL/DUSP6/LPIN2/PTPRA/PHLPP1/DUSP9/TNS3/PTPN14/CAMK2G/DLG1/PTPN12/PTPRF/PHPT1	15
GO:0000993	RNA polymerase II complex binding	4/730	50/18367	0.136584315635994	0.482033103872286	BRD4/NCOA3/RTF1/AGO2	4
GO:0005048	signal sequence binding	4/730	50/18367	0.136584315635994	0.482033103872286	CAT/TNPO1/KPNB1/KDELR2	4
GO:0004674	protein serine/threonine kinase activity	20/730	386/18367	0.137776871004619	0.482033103872286	MAP3K4/AAK1/BRD4/PNCK/TGFBR3/PRKDC/EGFR/NRK/LTBP1/STK17A/CSNK2B/ROCK1/LATS2/PKN2/CAMK2G/BRD2/NEK6/RIPK2/ENG/SGK1	20
GO:0019207	kinase regulator activity	13/730	233/18367	0.138193090557081	0.482033103872286	IGF2/RPLP1/CALM1/NPM1/HSPB1/SOCS1/CCNL1/PKIB/CSNK2B/IQGAP1/CDKN1A/CDKN1C/HMGB1	13
GO:0019956	chemokine binding	3/730	33/18367	0.142103010262597	0.482033103872286	ITGB1/ITGAV/HMGB1	3
GO:0004601	peroxidase activity	4/730	51/18367	0.143854037731907	0.482033103872286	GPX3/PRDX6/GPX4/CAT	4
GO:0000400	four-way junction DNA binding	2/730	17/18367	0.144979807394253	0.482033103872286	HMGB3/HMGB1	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/730	17/18367	0.144979807394253	0.482033103872286	PTPRA/PTPRF	2
GO:0015116	sulfate transmembrane transporter activity	2/730	17/18367	0.144979807394253	0.482033103872286	SLC26A2/SLC13A4	2
GO:0015174	basic amino acid transmembrane transporter activity	2/730	17/18367	0.144979807394253	0.482033103872286	SLC7A6/SLC38A9	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/730	17/18367	0.144979807394253	0.482033103872286	PTPRA/PTPRF	2
GO:0030275	LRR domain binding	2/730	17/18367	0.144979807394253	0.482033103872286	ERC1/DDIT3	2
GO:0031420	alkali metal ion binding	2/730	17/18367	0.144979807394253	0.482033103872286	PKM/TDG	2
GO:0031489	myosin V binding	2/730	17/18367	0.144979807394253	0.482033103872286	FUS/RAB11A	2
GO:0034185	apolipoprotein binding	2/730	17/18367	0.144979807394253	0.482033103872286	LRP1/HSPD1	2
GO:0042625	ATPase-coupled ion transmembrane transporter activity	2/730	17/18367	0.144979807394253	0.482033103872286	ATP6V0E1/ATP6V1G1	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/730	17/18367	0.144979807394253	0.482033103872286	KMT2C/ASH1L	2
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	2/730	17/18367	0.144979807394253	0.482033103872286	ATP6V0E1/ATP6V1G1	2
GO:0046961	proton-transporting ATPase activity, rotational mechanism	2/730	17/18367	0.144979807394253	0.482033103872286	ATP6V0E1/ATP6V1G1	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/730	17/18367	0.144979807394253	0.482033103872286	C1GALT1/B3GNT2	2
GO:0070064	proline-rich region binding	2/730	17/18367	0.144979807394253	0.482033103872286	GHR/PFN1	2
GO:0001098	basal transcription machinery binding	5/730	70/18367	0.145314816465436	0.482033103872286	BRD4/EDF1/NCOA3/RTF1/AGO2	5
GO:0001099	basal RNA polymerase II transcription machinery binding	5/730	70/18367	0.145314816465436	0.482033103872286	BRD4/EDF1/NCOA3/RTF1/AGO2	5
GO:0004879	nuclear receptor activity	4/730	52/18367	0.15127195443841	0.496465388325308	NR2F2/ESRRA/NR3C1/ESRRG	4
GO:0098531	ligand-activated transcription factor activity	4/730	52/18367	0.15127195443841	0.496465388325308	NR2F2/ESRRA/NR3C1/ESRRG	4
GO:0031491	nucleosome binding	5/730	71/18367	0.151569991966425	0.496465388325308	HP1BP3/HMGN3/CHD4/MBD3/SMARCA1	5
GO:1901981	phosphatidylinositol phosphate binding	10/730	173/18367	0.151899421399869	0.496465388325308	IQGAP2/PHLDA2/SLC9A1/IQGAP1/ARHGAP32/SYT7/PFN1/EXOC1/SNX27/SDCBP	10
GO:0008094	ATP-dependent activity, acting on DNA	7/730	111/18367	0.15314581277965	0.496885502047841	ANXA1/BPTF/ATRX/DHX36/RAD50/CHD4/SMARCA1	7
GO:0032182	ubiquitin-like protein binding	7/730	111/18367	0.15314581277965	0.496885502047841	CBX4/HSPB1/N4BP2/MDM2/TDG/UBE2A/UCHL3	7
GO:0003678	DNA helicase activity	5/730	72/18367	0.157935944152107	0.504231257453625	ANXA1/ATRX/DHX36/RAD50/CHD4	5
GO:0016829	lyase activity	11/730	196/18367	0.158457140597331	0.504231257453625	ALDOA/TPI1/PISD/HACD3/GLDC/APMAP/ENO1/HADHA/ECHDC2/CDYL/HMGB1	11
GO:0050661	NADP binding	4/730	53/18367	0.158831983099467	0.504231257453625	GAPDH/IDH1/CAT/HSD17B1	4
GO:0030228	lipoprotein particle receptor activity	2/730	18/18367	0.159016662553609	0.504231257453625	LRP1/LRP2	2
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/730	18/18367	0.159016662553609	0.504231257453625	CDC42/SASH1	2
GO:0055102	lipase inhibitor activity	2/730	18/18367	0.159016662553609	0.504231257453625	ANXA4/ANXA1	2
GO:0051213	dioxygenase activity	6/730	92/18367	0.15938018373956	0.504231257453625	TET2/P4HB/RSBN1L/KDM5A/ASPH/KDM5B	6
GO:0015370	solute:sodium symporter activity	5/730	73/18367	0.164409252636404	0.514647273217477	SLC6A8/SLC38A1/SLC13A4/SLC6A4/SLC20A1	5
GO:0106306	protein serine phosphatase activity	5/730	73/18367	0.164409252636404	0.514647273217477	DUSP1/CTDSPL/DUSP6/PHLPP1/DUSP9	5
GO:0106307	protein threonine phosphatase activity	5/730	73/18367	0.164409252636404	0.514647273217477	DUSP1/CTDSPL/DUSP6/PHLPP1/DUSP9	5
GO:0101005	deubiquitinase activity	7/730	114/18367	0.168420441895783	0.52416179757105	USP27X/USP10/USP22/USP48/USP9X/EIF3H/UCHL3	7
GO:0004386	helicase activity	9/730	156/18367	0.169193386863205	0.52416179757105	DDX5/ANXA1/ATRX/DHX36/RAD50/DICER1/DDX17/CHD4/SMARCA1	9
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	6/730	94/18367	0.170847678413508	0.52416179757105	AGL/GAA/GANAB/MAN1A2/HEXA/MANBA	6
GO:0023023	MHC protein complex binding	3/730	36/18367	0.170954684297988	0.52416179757105	PKM/HSPA8/B2M	3
GO:0061631	ubiquitin conjugating enzyme activity	3/730	36/18367	0.170954684297988	0.52416179757105	BIRC6/UBE2D3/UBE2A	3
GO:0005254	chloride channel activity	5/730	74/18367	0.17098641315591	0.52416179757105	CLIC3/FXYD3/GABRE/CLDN4/CLIC1	5
GO:0004129	cytochrome-c oxidase activity	2/730	19/18367	0.173289540529759	0.528671351405399	COX6A1/CYB5A	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	16/730	310/18367	0.173646833082538	0.528671351405399	NFE2L3/JUN/TBX3/PEG3/ZFHX3/ENO1/IRX2/CEBPB/MXD1/NR3C1/LRRFIP1/TFAP2A/HES1/ZNF217/BACH1/ATF3	16
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	4/730	55/18367	0.174353552422892	0.529011290457171	GPX3/PRDX6/GPX4/CAT	4
GO:0022853	active ion transmembrane transporter activity	14/730	267/18367	0.178397524258666	0.530565431429882	SLC26A2/ATP2B1/SLC6A8/SLC38A1/ATP6V0E1/SLC13A4/SLC6A4/SLC9A1/COX6A1/ATP13A3/SLC20A1/CYB5A/UQCRH/ATP6V1G1	14
GO:0005109	frizzled binding	3/730	37/18367	0.18091983038164	0.530565431429882	RNF43/ZNRF3/SDCBP	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3/730	37/18367	0.18091983038164	0.530565431429882	GAPDH/AKR1B1/ADH5	3
GO:0042056	chemoattractant activity	3/730	37/18367	0.18091983038164	0.530565431429882	MIF/PGF/HMGB1	3
GO:0030374	nuclear receptor coactivator activity	4/730	56/18367	0.182302489172063	0.530565431429882	NCOA3/CCAR1/USP22/NCOA2	4
GO:0045309	protein phosphorylated amino acid binding	4/730	56/18367	0.182302489172063	0.530565431429882	PFN1/RTF1/RASA1/CBLB	4
GO:0001217	DNA-binding transcription repressor activity	16/730	313/18367	0.183167925813132	0.530565431429882	NFE2L3/JUN/TBX3/PEG3/ZFHX3/ENO1/IRX2/CEBPB/MXD1/NR3C1/LRRFIP1/TFAP2A/HES1/ZNF217/BACH1/ATF3	16
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	22/730	450/18367	0.186189221856438	0.530565431429882	FOS/JUN/JUND/FOSB/TBX3/TFDP2/ISL1/RBPJ/ZFAT/NFE2L2/SOX4/PBX1/NFAT5/TFCP2L1/CEBPB/NR3C1/GTF2I/TFAP2A/DDIT3/ESRRG/BACH1/ATF3	22
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/730	20/18367	0.187757584545623	0.530565431429882	FOS/CEBPB	2
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	2/730	20/18367	0.187757584545623	0.530565431429882	ATP6V0E1/ATP6V1G1	2
GO:0016408	C-acyltransferase activity	2/730	20/18367	0.187757584545623	0.530565431429882	HADHA/SPTSSA	2
GO:0016500	protein-hormone receptor activity	2/730	20/18367	0.187757584545623	0.530565431429882	LGR5/LGR4	2
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	2/730	20/18367	0.187757584545623	0.530565431429882	GLDC/MAOA	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/730	20/18367	0.187757584545623	0.530565431429882	COX6A1/CYB5A	2
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	2/730	20/18367	0.187757584545623	0.530565431429882	CHPT1/CDS1	2
GO:0030506	ankyrin binding	2/730	20/18367	0.187757584545623	0.530565431429882	CDH1/PLEC	2
GO:0031681	G-protein beta-subunit binding	2/730	20/18367	0.187757584545623	0.530565431429882	GNG12/GNG5	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/730	20/18367	0.187757584545623	0.530565431429882	GNA12/GNAQ	2
GO:0031690	adrenergic receptor binding	2/730	20/18367	0.187757584545623	0.530565431429882	ADRB1/ARRDC3	2
GO:0061608	nuclear import signal receptor activity	2/730	20/18367	0.187757584545623	0.530565431429882	TNPO1/KPNB1	2
GO:0097001	ceramide binding	2/730	20/18367	0.187757584545623	0.530565431429882	PSAP/MAP1LC3B	2
GO:0003924	GTPase activity	17/730	337/18367	0.187995625309801	0.530565431429882	EEF1A1/GNA12/RHOA/GNAQ/RHOB/RALB/CDC42/HRAS/RHOBTB3/RASA1/RAB11A/GNG5/ARF4/RAB1A/RAC1/ARF1/ARL8B	17
GO:0043175	RNA polymerase core enzyme binding	4/730	57/18367	0.190368364569276	0.53238724595113	BRD4/NCOA3/RTF1/AGO2	4
GO:0022804	active transmembrane transporter activity	20/730	406/18367	0.190872224132314	0.53238724595113	SLC26A2/ATP2B1/SLC6A8/SLC16A12/SLC38A1/ATP6V0E1/SLC13A4/ABCB1/SLC6A4/SLC7A6/SLC9A1/COX6A1/ATP13A3/SLC20A1/MFSD12/CYB5A/UQCRH/SLC16A3/SLC7A5/ATP6V1G1	20
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/730	38/18367	0.191036593316547	0.53238724595113	NKTR/PPIG/PPIA	3
GO:0008395	steroid hydroxylase activity	3/730	38/18367	0.191036593316547	0.53238724595113	CYP2J2/CYP11A1/CYP19A1	3
GO:0004722	protein serine/threonine phosphatase activity	6/730	98/18367	0.194757052032354	0.541059435177384	DUSP1/CTDSPL/DUSP6/PHLPP1/DUSP9/CAMK2G	6
GO:0008028	monocarboxylic acid transmembrane transporter activity	4/730	58/18367	0.198544760912219	0.549863839411099	SLC16A12/SLC27A2/MPC2/SLC16A3	4
GO:0061650	ubiquitin-like protein conjugating enzyme activity	3/730	39/18367	0.201291835350799	0.552857498396454	BIRC6/UBE2D3/UBE2A	3
GO:0005123	death receptor binding	2/730	21/18367	0.202382804645597	0.552857498396454	CFLAR/TMBIM1	2
GO:0005243	gap junction channel activity	2/730	21/18367	0.202382804645597	0.552857498396454	GJA1/GJA5	2
GO:0140416	transcription regulator inhibitor activity	2/730	21/18367	0.202382804645597	0.552857498396454	PURA/DDIT3	2
GO:0001216	DNA-binding transcription activator activity	22/730	456/18367	0.202735145643694	0.552857498396454	FOS/JUN/JUND/FOSB/TBX3/TFDP2/ISL1/RBPJ/ZFAT/NFE2L2/SOX4/PBX1/NFAT5/TFCP2L1/CEBPB/NR3C1/GTF2I/TFAP2A/DDIT3/ESRRG/BACH1/ATF3	22
GO:0004177	aminopeptidase activity	3/730	40/18367	0.211672641098834	0.571090219870009	ENPEP/CTSV/DPP7	3
GO:0031492	nucleosomal DNA binding	3/730	40/18367	0.211672641098834	0.571090219870009	HMGN3/CHD4/MBD3	3
GO:0030295	protein kinase activator activity	6/730	101/18367	0.21346533371594	0.571090219870009	IGF2/RPLP1/CALM1/IQGAP1/CDKN1A/HMGB1	6
GO:0015293	symporter activity	8/730	144/18367	0.214773499831574	0.571090219870009	SLC6A8/SLC16A12/SLC38A1/SLC13A4/SLC6A4/SLC20A1/MFSD12/SLC16A3	8
GO:0000062	fatty-acyl-CoA binding	2/730	22/18367	0.217129914866212	0.571090219870009	DBI/HADHA	2
GO:0005355	glucose transmembrane transporter activity	2/730	22/18367	0.217129914866212	0.571090219870009	SLC2A8/SLC2A12	2
GO:0005537	mannose binding	2/730	22/18367	0.217129914866212	0.571090219870009	LMAN1/MANBA	2
GO:0008093	cytoskeletal anchor activity	2/730	22/18367	0.217129914866212	0.571090219870009	EPB41L3/SDCBP	2
GO:0015149	hexose transmembrane transporter activity	2/730	22/18367	0.217129914866212	0.571090219870009	SLC2A8/SLC2A12	2
GO:0015296	anion:cation symporter activity	2/730	22/18367	0.217129914866212	0.571090219870009	SLC13A4/SLC6A4	2
GO:0017075	syntaxin-1 binding	2/730	22/18367	0.217129914866212	0.571090219870009	SLC6A4/VAMP2	2
GO:0070034	telomerase RNA binding	2/730	22/18367	0.217129914866212	0.571090219870009	DHX36/NOP10	2
GO:0016859	cis-trans isomerase activity	3/730	41/18367	0.222166343583544	0.579196127406953	NKTR/PPIG/PPIA	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/730	41/18367	0.222166343583544	0.579196127406953	ACSS1/SLC27A2/UBA5	3
GO:0030331	estrogen receptor binding	3/730	41/18367	0.222166343583544	0.579196127406953	FUS/ISL1/PARP1	3
GO:0015179	L-amino acid transmembrane transporter activity	4/730	61/18367	0.22367271280916	0.581418250547787	SLC38A1/SLC7A6/SLC38A9/SLC7A5	4
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	5/730	82/18367	0.226900467022755	0.588088965548773	SLC9A1/SYT7/PFN1/EXOC1/SDCBP	5
GO:0019783	ubiquitin-like protein-specific protease activity	7/730	125/18367	0.229544860670431	0.593213317255852	USP27X/USP10/USP22/USP48/USP9X/EIF3H/UCHL3	7
GO:0140103	catalytic activity, acting on a glycoprotein	2/730	23/18367	0.23196617879344	0.594609558179315	C1GALT1/FUT8	2
GO:1901567	fatty acid derivative binding	2/730	23/18367	0.23196617879344	0.594609558179315	DBI/HADHA	2
GO:0019205	nucleobase-containing compound kinase activity	3/730	42/18367	0.232760546958832	0.594609558179315	N4BP2/DLG1/AK3	3
GO:0019894	kinesin binding	3/730	42/18367	0.232760546958832	0.594609558179315	KTN1/SPAG9/NEK6	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	9/730	170/18367	0.235816405158226	0.600689926033419	CYP2J2/CYP11A1/TET2/SCD/P4HB/KDM5A/ASPH/KDM5B/CYP19A1	9
GO:0015171	amino acid transmembrane transporter activity	5/730	84/18367	0.241654745295249	0.612201294294664	SLC38A1/SLC7A6/SLC38A9/MFSD12/SLC7A5	5
GO:0046906	tetrapyrrole binding	8/730	149/18367	0.241712771988107	0.612201294294664	CYP2J2/CYP11A1/MTR/CAT/CYB5A/BACH1/CYP19A1/CYBA	8
GO:0018024	histone-lysine N-methyltransferase activity	3/730	43/18367	0.243443146170194	0.61385766773175	KMT2C/ASH1L/SETD2	3
GO:0033218	amide binding	19/730	400/18367	0.243747757828243	0.61385766773175	LRP1/DHCR24/ENPEP/PSAP/DBI/LRPAP1/ITM2B/CTSV/NKTR/GHR/PPIG/CAT/TNPO1/HADHA/KPNB1/KDELR2/MAP1LC3B/SLC7A5/PPIA	19
GO:0015145	monosaccharide transmembrane transporter activity	2/730	24/18367	0.246861263098605	0.618196233506084	SLC2A8/SLC2A12	2
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	2/730	24/18367	0.246861263098605	0.618196233506084	BMP7/GDF15	2
GO:0015291	secondary active transmembrane transporter activity	12/730	240/18367	0.247866325003478	0.618969558786775	SLC26A2/SLC6A8/SLC16A12/SLC38A1/SLC13A4/SLC6A4/SLC7A6/SLC9A1/SLC20A1/MFSD12/SLC16A3/SLC7A5	12
GO:0050660	flavin adenine dinucleotide binding	5/730	85/18367	0.249126804608273	0.62037459186766	DHCR24/MAOA/ERO1A/TXNRD1/SDHA	5
GO:0019209	kinase activator activity	6/730	107/18367	0.252577542258624	0.624270396776717	IGF2/RPLP1/CALM1/IQGAP1/CDKN1A/HMGB1	6
GO:0031072	heat shock protein binding	7/730	129/18367	0.253444275040596	0.624270396776717	HSPA8/TFAM/HSPA5/HSPA1A/NR3C1/KPNB1/DNAJB14	7
GO:0001784	phosphotyrosine residue binding	3/730	44/18367	0.254202343794344	0.624270396776717	PFN1/RASA1/CBLB	3
GO:0008375	acetylglucosaminyltransferase activity	3/730	44/18367	0.254202343794344	0.624270396776717	EXTL2/B3GNT2/HEXA	3
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3/730	44/18367	0.254202343794344	0.624270396776717	GAPDH/AKR1B1/ADH5	3
GO:0042562	hormone binding	5/730	86/18367	0.256656905966483	0.628561954281552	LRP2/EGFR/GHR/NR3C1/SEC61B	5
GO:0015103	inorganic anion transmembrane transporter activity	8/730	152/18367	0.258395027601083	0.630701167242011	SLC26A2/CLIC3/FXYD3/GABRE/SLC13A4/SLC6A4/CLDN4/CLIC1	8
GO:0005112	Notch binding	2/730	25/18367	0.261787098664007	0.630701167242011	GALNT11/AAK1	2
GO:0005160	transforming growth factor beta receptor binding	2/730	25/18367	0.261787098664007	0.630701167242011	TGFBR3/ENG	2
GO:0030247	polysaccharide binding	2/730	25/18367	0.261787098664007	0.630701167242011	AGL/GPCPD1	2
GO:0051019	mitogen-activated protein kinase binding	2/730	25/18367	0.261787098664007	0.630701167242011	DUSP1/IQGAP1	2
GO:0120227	acyl-CoA binding	2/730	25/18367	0.261787098664007	0.630701167242011	DBI/HADHA	2
GO:0005253	anion channel activity	5/730	87/18367	0.264241128097849	0.634778962320902	CLIC3/FXYD3/GABRE/CLDN4/CLIC1	5
GO:0000287	magnesium ion binding	11/730	221/18367	0.264907755929195	0.634778962320902	PKM/PDCD6/IDH1/ENO1/GLUL/S100P/DHX36/TDG/NEK6/PGM2/ARF1	11
GO:0042626	ATPase-coupled transmembrane transporter activity	6/730	109/18367	0.266039232180167	0.635776552172495	SLC26A2/ATP2B1/ATP6V0E1/ABCB1/ATP13A3/ATP6V1G1	6
GO:0051219	phosphoprotein binding	5/730	88/18367	0.271875562134589	0.647982237902546	CBX4/PFN1/RTF1/RASA1/CBLB	5
GO:0004864	protein phosphatase inhibitor activity	3/730	46/18367	0.275904965823259	0.652525407948577	PPP1R10/BOD1L1/PPP1R14B	3
GO:0061659	ubiquitin-like protein ligase activity	15/730	316/18367	0.276587643727878	0.652525407948577	NEURL1/CBX4/RNF43/ZNRF3/MYCBP2/TRIM44/ZNF451/UFL1/MDM2/RANBP2/HUWE1/CDC42/MYLIP/UBE2D3/CBLB	15
GO:0008198	ferrous iron binding	2/730	26/18367	0.276717748927574	0.652525407948577	FTH1/TET2	2
GO:0097602	cullin family protein binding	2/730	26/18367	0.276717748927574	0.652525407948577	DDB1/SKP1	2
GO:0001664	G protein-coupled receptor binding	14/730	295/18367	0.285962049330549	0.66819184136072	WLS/ITGB4/HSPA8/ADRB1/CALM1/RNF43/GNA12/ARRDC3/ZNRF3/HOMER1/GNAQ/APELA/HSPA1A/SDCBP	14
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/730	47/18367	0.286826450006305	0.66819184136072	DUSP1/DUSP6/DUSP9	3
GO:0035254	glutamate receptor binding	3/730	47/18367	0.286826450006305	0.66819184136072	FUS/CALM1/HOMER1	3
GO:0016887	ATP hydrolysis activity	13/730	272/18367	0.28714232897563	0.66819184136072	ATP2B1/KIF5B/HSPD1/HSPA8/DDX5/HSPA5/ATRX/DHX36/HSPA1A/ATP13A3/DDX17/RHOBTB3/CHD4	13
GO:0042578	phosphoric ester hydrolase activity	17/730	366/18367	0.288920465880105	0.66819184136072	PLPP3/DUSP1/CTDSPL/DUSP6/LPIN2/PTPRA/PDE4B/PHLPP1/DUSP9/TNS3/PTPN14/CAMK2G/DLG1/GPCPD1/PTPN12/PTPRF/PHPT1	17
GO:0004683	calmodulin-dependent protein kinase activity	2/730	27/18367	0.291629285093318	0.66819184136072	PNCK/CAMK2G	2
GO:0008139	nuclear localization sequence binding	2/730	27/18367	0.291629285093318	0.66819184136072	TNPO1/KPNB1	2
GO:0016405	CoA-ligase activity	2/730	27/18367	0.291629285093318	0.66819184136072	ACSS1/SLC27A2	2
GO:0016866	intramolecular transferase activity	2/730	27/18367	0.291629285093318	0.66819184136072	CYP2J2/PGM2	2
GO:0051119	sugar transmembrane transporter activity	2/730	27/18367	0.291629285093318	0.66819184136072	SLC2A8/SLC2A12	2
GO:0051393	alpha-actinin binding	2/730	27/18367	0.291629285093318	0.66819184136072	DAG1/PDLIM2	2
GO:0004843	thiol-dependent deubiquitinase	6/730	113/18367	0.293469059974441	0.669522812245764	USP27X/USP10/USP22/USP48/USP9X/UCHL3	6
GO:0015399	primary active transmembrane transporter activity	9/730	181/18367	0.293716419320414	0.669522812245764	SLC26A2/ATP2B1/ATP6V0E1/ABCB1/COX6A1/ATP13A3/CYB5A/UQCRH/ATP6V1G1	9
GO:0042277	peptide binding	15/730	321/18367	0.296722586227253	0.674645470987283	LRP1/DHCR24/ENPEP/LRPAP1/ITM2B/CTSV/NKTR/GHR/PPIG/CAT/TNPO1/KPNB1/KDELR2/SLC7A5/PPIA	15
GO:0043130	ubiquitin binding	5/730	92/18367	0.302837958899752	0.675947478876966	HSPB1/N4BP2/MDM2/UBE2A/UCHL3	5
GO:0140097	catalytic activity, acting on DNA	11/730	229/18367	0.303188000565867	0.675947478876966	ANXA1/DNMT3A/BPTF/ATRX/DHX36/RAD50/DICER1/TDG/DNMT1/CHD4/SMARCA1	11
GO:0015101	organic cation transmembrane transporter activity	2/730	28/18367	0.306499667870935	0.675947478876966	SLC19A3/ATP13A3	2
GO:0016763	pentosyltransferase activity	3/730	49/18367	0.308757533865694	0.675947478876966	UPP1/PARP1/PNP	3
GO:0019212	phosphatase inhibitor activity	3/730	49/18367	0.308757533865694	0.675947478876966	PPP1R10/BOD1L1/PPP1R14B	3
GO:0043539	protein serine/threonine kinase activator activity	3/730	49/18367	0.308757533865694	0.675947478876966	IGF2/CALM1/IQGAP1	3
GO:0020037	heme binding	7/730	139/18367	0.315958817304514	0.675947478876966	CYP2J2/CYP11A1/CAT/CYB5A/BACH1/CYP19A1/CYBA	7
GO:0008083	growth factor activity	8/730	162/18367	0.316212923988823	0.675947478876966	IGF2/EFEMP1/PGF/CSH1/GRN/BMP7/INHA/GDF15	8
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3/730	50/18367	0.319747313752696	0.675947478876966	SLC29A3/SLC25A36/SLC35B4	3
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	3/730	50/18367	0.319747313752696	0.675947478876966	CCNL1/CDKN1A/CDKN1C	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/730	29/18367	0.321308635423803	0.675947478876966	AKR1B1/DHCR24	2
GO:0032452	histone demethylase activity	2/730	29/18367	0.321308635423803	0.675947478876966	KDM5A/KDM5B	2
GO:0046625	sphingolipid binding	2/730	29/18367	0.321308635423803	0.675947478876966	PSAP/MAP1LC3B	2
GO:0051059	NF-kappaB binding	2/730	29/18367	0.321308635423803	0.675947478876966	ANXA4/NPM1	2
GO:0140457	protein demethylase activity	2/730	29/18367	0.321308635423803	0.675947478876966	KDM5A/KDM5B	2
GO:0046982	protein heterodimerization activity	15/730	328/18367	0.325609012515497	0.675947478876966	CAV1/ITGB1/TENM3/ADRB1/JAM3/P4HB/BCL2/CEBPB/HEXA/DDIT3/TPM4/SRI/ATF3/SDCBP/CYBA	15
GO:0033293	monocarboxylic acid binding	4/730	73/18367	0.33014282638826	0.675947478876966	S100A9/NR2F2/PSAP/ADH5	4
GO:0051018	protein kinase A binding	3/730	51/18367	0.330740643503995	0.675947478876966	AKAP9/EZR/WASF2	3
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/730	10/18367	0.333468263829661	0.675947478876966	RAD50	1
GO:0001094	TFIID-class transcription factor complex binding	1/730	10/18367	0.333468263829661	0.675947478876966	EDF1	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/730	10/18367	0.333468263829661	0.675947478876966	PTPN12	1
GO:0005522	profilin binding	1/730	10/18367	0.333468263829661	0.675947478876966	ACTG1	1
GO:0008097	5S rRNA binding	1/730	10/18367	0.333468263829661	0.675947478876966	MDM2	1
GO:0008190	eukaryotic initiation factor 4E binding	1/730	10/18367	0.333468263829661	0.675947478876966	LARP1	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	1/730	10/18367	0.333468263829661	0.675947478876966	UBA5	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/730	10/18367	0.333468263829661	0.675947478876966	SLC35B4	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/730	10/18367	0.333468263829661	0.675947478876966	SLC7A5	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/730	10/18367	0.333468263829661	0.675947478876966	MAN1A2	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/730	10/18367	0.333468263829661	0.675947478876966	CYBA	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	1/730	10/18367	0.333468263829661	0.675947478876966	PIK3CB	1
GO:0016595	glutamate binding	1/730	10/18367	0.333468263829661	0.675947478876966	GLUL	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/730	10/18367	0.333468263829661	0.675947478876966	SCD	1
GO:0016783	sulfurtransferase activity	1/730	10/18367	0.333468263829661	0.675947478876966	MOCS2	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/730	10/18367	0.333468263829661	0.675947478876966	PGM2	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	1/730	10/18367	0.333468263829661	0.675947478876966	ADH5	1
GO:0019531	oxalate transmembrane transporter activity	1/730	10/18367	0.333468263829661	0.675947478876966	SLC26A2	1
GO:0030957	Tat protein binding	1/730	10/18367	0.333468263829661	0.675947478876966	NPM1	1
GO:0031419	cobalamin binding	1/730	10/18367	0.333468263829661	0.675947478876966	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/730	10/18367	0.333468263829661	0.675947478876966	SLC27A2	1
GO:0034713	type I transforming growth factor beta receptor binding	1/730	10/18367	0.333468263829661	0.675947478876966	ENG	1
GO:0035612	AP-2 adaptor complex binding	1/730	10/18367	0.333468263829661	0.675947478876966	AAK1	1
GO:0043208	glycosphingolipid binding	1/730	10/18367	0.333468263829661	0.675947478876966	PSAP	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/730	10/18367	0.333468263829661	0.675947478876966	ASH1L	1
GO:0052813	phosphatidylinositol bisphosphate kinase activity	1/730	10/18367	0.333468263829661	0.675947478876966	PIK3CB	1
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	1/730	10/18367	0.333468263829661	0.675947478876966	CFLAR	1
GO:0098505	G-rich strand telomeric DNA binding	1/730	10/18367	0.333468263829661	0.675947478876966	HNRNPA1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/730	10/18367	0.333468263829661	0.675947478876966	ADRB1	1
GO:0017147	Wnt-protein binding	2/730	30/18367	0.336037597219711	0.675947478876966	WLS/LRP5	2
GO:0022829	wide pore channel activity	2/730	30/18367	0.336037597219711	0.675947478876966	GJA1/GJA5	2
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2/730	30/18367	0.336037597219711	0.675947478876966	HSD3B1/HSD17B1	2
GO:0019905	syntaxin binding	4/730	74/18367	0.339237478572965	0.675947478876966	SLC6A4/SYT7/VAMP2/RAB11A	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	7/730	144/18367	0.348219499975157	0.675947478876966	AGL/GAA/GANAB/MAN1A2/HEXA/MANBA/TDG	7
GO:0000146	microfilament motor activity	2/730	31/18367	0.35066953349313	0.675947478876966	MYH10/MYL6	2
GO:0008157	protein phosphatase 1 binding	2/730	31/18367	0.35066953349313	0.675947478876966	PPP1R9A/PPP1R15A	2
GO:0016878	acid-thiol ligase activity	2/730	31/18367	0.35066953349313	0.675947478876966	ACSS1/SLC27A2	2
GO:0071813	lipoprotein particle binding	2/730	31/18367	0.35066953349313	0.675947478876966	HSPD1/COLEC12	2
GO:0071814	protein-lipid complex binding	2/730	31/18367	0.35066953349313	0.675947478876966	HSPD1/COLEC12	2
GO:0140142	nucleocytoplasmic carrier activity	2/730	31/18367	0.35066953349313	0.675947478876966	TNPO1/KPNB1	2
GO:0140318	protein transporter activity	2/730	31/18367	0.35066953349313	0.675947478876966	LRP2/SEC61G	2
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	1/730	11/18367	0.359974129025736	0.675947478876966	NCOA2	1
GO:0005436	sodium:phosphate symporter activity	1/730	11/18367	0.359974129025736	0.675947478876966	SLC20A1	1
GO:0008199	ferric iron binding	1/730	11/18367	0.359974129025736	0.675947478876966	FTH1	1
GO:0008503	benzodiazepine receptor activity	1/730	11/18367	0.359974129025736	0.675947478876966	GABRE	1
GO:0008603	cAMP-dependent protein kinase regulator activity	1/730	11/18367	0.359974129025736	0.675947478876966	PKIB	1
GO:0010485	H4 histone acetyltransferase activity	1/730	11/18367	0.359974129025736	0.675947478876966	USP22	1
GO:0015378	sodium:chloride symporter activity	1/730	11/18367	0.359974129025736	0.675947478876966	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/730	11/18367	0.359974129025736	0.675947478876966	SLC9A1	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/730	11/18367	0.359974129025736	0.675947478876966	ARG2	1
GO:0016832	aldehyde-lyase activity	1/730	11/18367	0.359974129025736	0.675947478876966	ALDOA	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/730	11/18367	0.359974129025736	0.675947478876966	GLCE	1
GO:0019107	myristoyltransferase activity	1/730	11/18367	0.359974129025736	0.675947478876966	NMT1	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/730	11/18367	0.359974129025736	0.675947478876966	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/730	11/18367	0.359974129025736	0.675947478876966	DLG1	1
GO:0035673	oligopeptide transmembrane transporter activity	1/730	11/18367	0.359974129025736	0.675947478876966	GJA1	1
GO:0042608	T cell receptor binding	1/730	11/18367	0.359974129025736	0.675947478876966	EPS8L1	1
GO:0047676	arachidonate-CoA ligase activity	1/730	11/18367	0.359974129025736	0.675947478876966	SLC27A2	1
GO:0051400	BH domain binding	1/730	11/18367	0.359974129025736	0.675947478876966	BCL2	1
GO:0070513	death domain binding	1/730	11/18367	0.359974129025736	0.675947478876966	BCL2	1
GO:0097371	MDM2/MDM4 family protein binding	1/730	11/18367	0.359974129025736	0.675947478876966	RPS20	1
GO:1901474	azole transmembrane transporter activity	1/730	11/18367	0.359974129025736	0.675947478876966	SLC19A3	1
GO:0005544	calcium-dependent phospholipid binding	3/730	54/18367	0.363653748672544	0.675947478876966	ANXA4/ANXA1/SYT7	3
GO:0008378	galactosyltransferase activity	2/730	32/18367	0.365188900041582	0.675947478876966	C1GALT1/B3GNT2	2
GO:0050699	WW domain binding	2/730	32/18367	0.365188900041582	0.675947478876966	TCEAL4/PRRG4	2
GO:0051721	protein phosphatase 2A binding	2/730	32/18367	0.365188900041582	0.675947478876966	BCL2/BOD1L1	2
GO:0005496	steroid binding	5/730	100/18367	0.366020241717432	0.675947478876966	CAV1/ESRRA/NR3C1/HSD17B1/ESRRG	5
GO:0038024	cargo receptor activity	4/730	77/18367	0.366549520587661	0.675947478876966	LRP1/LRP2/TFRC/COLEC12	4
GO:0005080	protein kinase C binding	3/730	55/18367	0.374574913840793	0.675947478876966	ITGAV/HSPB1/HINT1	3
GO:0001221	transcription coregulator binding	4/730	78/18367	0.375646197081698	0.675947478876966	NFE2L2/TFAM/NEK6/CHD4	4
GO:0005096	GTPase activator activity	20/730	462/18367	0.379499147685226	0.675947478876966	SYDE1/IQGAP2/JUN/HACD3/ADRB1/ARHGAP18/EEF1B2/EPS8L1/NF1/MYCBP2/GNAQ/NUCB2/CHML/IQGAP1/ARHGAP32/ARHGAP23/NET1/RANBP2/RASA1/ARF4	20
GO:0001530	lipopolysaccharide binding	2/730	33/18367	0.37958153809184	0.675947478876966	HSPD1/HMGB1	2
GO:0005154	epidermal growth factor receptor binding	2/730	33/18367	0.37958153809184	0.675947478876966	EFEMP1/ARF4	2
GO:0031369	translation initiation factor binding	2/730	33/18367	0.37958153809184	0.675947478876966	LARP1/EIF2S2	2
GO:0016758	hexosyltransferase activity	9/730	197/18367	0.383042088344983	0.675947478876966	GALNT11/AGL/EXTL2/C1GALT1/RPN2/B3GNT2/HEXA/FUT8/B3GAT3	9
GO:0008242	omega peptidase activity	6/730	126/18367	0.385408636386576	0.675947478876966	USP27X/USP10/USP22/USP48/USP9X/UCHL3	6
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/730	12/18367	0.385427326117216	0.675947478876966	AKR1B1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/730	12/18367	0.385427326117216	0.675947478876966	SLC35B4	1
GO:0008174	mRNA methyltransferase activity	1/730	12/18367	0.385427326117216	0.675947478876966	CMTR1	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/730	12/18367	0.385427326117216	0.675947478876966	BRD4	1
GO:0008429	phosphatidylethanolamine binding	1/730	12/18367	0.385427326117216	0.675947478876966	NF1	1
GO:0015269	calcium-activated potassium channel activity	1/730	12/18367	0.385427326117216	0.675947478876966	KCNN4	1
GO:0030955	potassium ion binding	1/730	12/18367	0.385427326117216	0.675947478876966	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/730	12/18367	0.385427326117216	0.675947478876966	P4HB	1
GO:0033130	acetylcholine receptor binding	1/730	12/18367	0.385427326117216	0.675947478876966	LY6E	1
GO:0034452	dynactin binding	1/730	12/18367	0.385427326117216	0.675947478876966	HOOK3	1
GO:0035004	phosphatidylinositol 3-kinase activity	1/730	12/18367	0.385427326117216	0.675947478876966	PIK3CB	1
GO:0035325	Toll-like receptor binding	1/730	12/18367	0.385427326117216	0.675947478876966	S100A9	1
GO:0042975	peroxisome proliferator activated receptor binding	1/730	12/18367	0.385427326117216	0.675947478876966	MDM2	1
GO:0043176	amine binding	1/730	12/18367	0.385427326117216	0.675947478876966	SLC6A4	1
GO:0046790	virion binding	1/730	12/18367	0.385427326117216	0.675947478876966	PPIA	1
GO:0051378	serotonin binding	1/730	12/18367	0.385427326117216	0.675947478876966	SLC6A4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/730	12/18367	0.385427326117216	0.675947478876966	USP27X	1
GO:0070410	co-SMAD binding	1/730	12/18367	0.385427326117216	0.675947478876966	USP9X	1
GO:0089720	caspase binding	1/730	12/18367	0.385427326117216	0.675947478876966	RIPK2	1
GO:0042054	histone methyltransferase activity	3/730	56/18367	0.385458258633363	0.675947478876966	KMT2C/ASH1L/SETD2	3
GO:0030695	GTPase regulator activity	21/730	488/18367	0.385495356344906	0.675947478876966	SYDE1/IQGAP2/JUN/HACD3/ADRB1/ARHGAP18/EEF1B2/EPS8L1/NF1/MYCBP2/GNAQ/NUCB2/CHML/GPSM2/IQGAP1/ARHGAP32/ARHGAP23/NET1/RANBP2/RASA1/ARF4	21
GO:0060589	nucleoside-triphosphatase regulator activity	21/730	488/18367	0.385495356344906	0.675947478876966	SYDE1/IQGAP2/JUN/HACD3/ADRB1/ARHGAP18/EEF1B2/EPS8L1/NF1/MYCBP2/GNAQ/NUCB2/CHML/GPSM2/IQGAP1/ARHGAP32/ARHGAP23/NET1/RANBP2/RASA1/ARF4	21
GO:0016757	glycosyltransferase activity	12/730	270/18367	0.387728050293304	0.678524088013282	GALNT11/AGL/EXTL2/C1GALT1/UPP1/PARP1/PNP/RPN2/B3GNT2/HEXA/FUT8/B3GAT3	12
GO:0005200	structural constituent of cytoskeleton	5/730	103/18367	0.389851551800868	0.679564763825435	KRT19/ACTG1/PLEC/ARPC3/EPB41L3	5
GO:0008238	exopeptidase activity	5/730	103/18367	0.389851551800868	0.679564763825435	TFRC/CTSC/ENPEP/CTSV/DPP7	5
GO:0008376	acetylgalactosaminyltransferase activity	2/730	34/18367	0.393834588984176	0.681073046655994	GALNT11/EXTL2	2
GO:0016229	steroid dehydrogenase activity	2/730	34/18367	0.393834588984176	0.681073046655994	HSD3B1/HSD17B1	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/730	34/18367	0.393834588984176	0.681073046655994	DICER1/AGO2	2
GO:0005506	iron ion binding	7/730	151/18367	0.393898319559986	0.681073046655994	CYP2J2/CYP11A1/FTH1/TET2/SCD/CYP19A1/FDX1	7
GO:0015294	solute:cation symporter activity	5/730	104/18367	0.397785337375286	0.681073046655994	SLC6A8/SLC38A1/SLC13A4/SLC6A4/SLC20A1	5
GO:0035591	signaling adaptor activity	4/730	81/18367	0.402847907353431	0.681073046655994	DLG5/HOMER1/SPAG9/IQGAP1	4
GO:0002161	aminoacyl-tRNA editing activity	1/730	13/18367	0.409869606255294	0.681073046655994	IARS2	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/730	13/18367	0.409869606255294	0.681073046655994	PPP1R14B	1
GO:0008035	high-density lipoprotein particle binding	1/730	13/18367	0.409869606255294	0.681073046655994	HSPD1	1
GO:0008179	adenylate cyclase binding	1/730	13/18367	0.409869606255294	0.681073046655994	CALM1	1
GO:0008417	fucosyltransferase activity	1/730	13/18367	0.409869606255294	0.681073046655994	FUT8	1
GO:0008494	translation activator activity	1/730	13/18367	0.409869606255294	0.681073046655994	LARP1	1
GO:0015385	sodium:proton antiporter activity	1/730	13/18367	0.409869606255294	0.681073046655994	SLC9A1	1
GO:0016594	glycine binding	1/730	13/18367	0.409869606255294	0.681073046655994	GLDC	1
GO:0016840	carbon-nitrogen lyase activity	1/730	13/18367	0.409869606255294	0.681073046655994	APMAP	1
GO:0019104	DNA N-glycosylase activity	1/730	13/18367	0.409869606255294	0.681073046655994	TDG	1
GO:0022851	GABA-gated chloride ion channel activity	1/730	13/18367	0.409869606255294	0.681073046655994	GABRE	1
GO:0031386	protein tag	1/730	13/18367	0.409869606255294	0.681073046655994	UBA52	1
GO:0031432	titin binding	1/730	13/18367	0.409869606255294	0.681073046655994	CALM1	1
GO:0032036	myosin heavy chain binding	1/730	13/18367	0.409869606255294	0.681073046655994	MYL12B	1
GO:0034236	protein kinase A catalytic subunit binding	1/730	13/18367	0.409869606255294	0.681073046655994	EZR	1
GO:0045159	myosin II binding	1/730	13/18367	0.409869606255294	0.681073046655994	TRIOBP	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/730	13/18367	0.409869606255294	0.681073046655994	HSD17B1	1
GO:0140299	small molecule sensor activity	1/730	13/18367	0.409869606255294	0.681073046655994	EFHD1	1
GO:0140333	glycerophospholipid flippase activity	1/730	13/18367	0.409869606255294	0.681073046655994	ABCB1	1
GO:0015078	proton transmembrane transporter activity	6/730	130/18367	0.413948863939691	0.686568171720867	ATP6V0E1/SLC9A1/COX6A1/CYB5A/UQCRH/ATP6V1G1	6
GO:0016279	protein-lysine N-methyltransferase activity	3/730	59/18367	0.417811146068919	0.688037068991017	KMT2C/ASH1L/SETD2	3
GO:1902936	phosphatidylinositol bisphosphate binding	5/730	107/18367	0.421513493121983	0.688037068991017	SLC9A1/SYT7/PFN1/EXOC1/SDCBP	5
GO:0000217	DNA secondary structure binding	2/730	36/18367	0.421876515148848	0.688037068991017	HMGB3/HMGB1	2
GO:0042605	peptide antigen binding	2/730	36/18367	0.421876515148848	0.688037068991017	DHCR24/SLC7A5	2
GO:0042805	actinin binding	2/730	36/18367	0.421876515148848	0.688037068991017	DAG1/PDLIM2	2
GO:0001786	phosphatidylserine binding	3/730	60/18367	0.428474713253609	0.688037068991017	HSPA8/SYT7/HMGB1	3
GO:0016278	lysine N-methyltransferase activity	3/730	60/18367	0.428474713253609	0.688037068991017	KMT2C/ASH1L/SETD2	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/730	60/18367	0.428474713253609	0.688037068991017	AKR1B1/DHCR24/SDHA	3
GO:0005525	GTP binding	16/730	377/18367	0.430153146043891	0.688037068991017	EEF1A1/GNA12/RHOA/GNAQ/RHOB/RALB/CDC42/HRAS/AK3/RHOBTB3/RAB11A/ARF4/RAB1A/RAC1/ARF1/ARL8B	16
GO:0005172	vascular endothelial growth factor receptor binding	1/730	14/18367	0.433341066832479	0.688037068991017	PGF	1
GO:0005451	monovalent cation:proton antiporter activity	1/730	14/18367	0.433341066832479	0.688037068991017	SLC9A1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/730	14/18367	0.433341066832479	0.688037068991017	B3GNT2	1
GO:0019992	diacylglycerol binding	1/730	14/18367	0.433341066832479	0.688037068991017	CHPT1	1
GO:0030983	mismatched DNA binding	1/730	14/18367	0.433341066832479	0.688037068991017	TDG	1
GO:0035259	glucocorticoid receptor binding	1/730	14/18367	0.433341066832479	0.688037068991017	CEBPB	1
GO:0036041	long-chain fatty acid binding	1/730	14/18367	0.433341066832479	0.688037068991017	S100A9	1
GO:0043023	ribosomal large subunit binding	1/730	14/18367	0.433341066832479	0.688037068991017	NPM1	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/730	14/18367	0.433341066832479	0.688037068991017	HSD17B1	1
GO:0071837	HMG box domain binding	1/730	14/18367	0.433341066832479	0.688037068991017	JUN	1
GO:0016409	palmitoyltransferase activity	2/730	37/18367	0.435645468564118	0.688037068991017	GLUL/SPTSSA	2
GO:0071949	FAD binding	2/730	37/18367	0.435645468564118	0.688037068991017	DHCR24/ERO1A	2
GO:0000149	SNARE binding	5/730	110/18367	0.445070787318639	0.688037068991017	SLC6A4/SYT7/UVRAG/VAMP2/RAB11A	5
GO:0004520	endodeoxyribonuclease activity	2/730	38/18367	0.449234850522316	0.688037068991017	RAD50/DICER1	2
GO:0005501	retinoid binding	2/730	38/18367	0.449234850522316	0.688037068991017	NR2F2/OPN3	2
GO:0019840	isoprenoid binding	2/730	38/18367	0.449234850522316	0.688037068991017	NR2F2/OPN3	2
GO:0001846	opsonin binding	1/730	15/18367	0.455880216901257	0.688037068991017	ITGAV	1
GO:0004029	aldehyde dehydrogenase (NAD+) activity	1/730	15/18367	0.455880216901257	0.688037068991017	ADH5	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/730	15/18367	0.455880216901257	0.688037068991017	PDE4B	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/730	15/18367	0.455880216901257	0.688037068991017	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/730	15/18367	0.455880216901257	0.688037068991017	MAN1A2	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/730	15/18367	0.455880216901257	0.688037068991017	GABRE	1
GO:0008020	G protein-coupled photoreceptor activity	1/730	15/18367	0.455880216901257	0.688037068991017	OPN3	1
GO:0008559	ABC-type xenobiotic transporter activity	1/730	15/18367	0.455880216901257	0.688037068991017	ABCB1	1
GO:0010851	cyclase regulator activity	1/730	15/18367	0.455880216901257	0.688037068991017	CALM1	1
GO:0015929	hexosaminidase activity	1/730	15/18367	0.455880216901257	0.688037068991017	HEXA	1
GO:0030548	acetylcholine receptor regulator activity	1/730	15/18367	0.455880216901257	0.688037068991017	LY6E	1
GO:0032794	GTPase activating protein binding	1/730	15/18367	0.455880216901257	0.688037068991017	CDH1	1
GO:0042043	neurexin family protein binding	1/730	15/18367	0.455880216901257	0.688037068991017	SDCBP	1
GO:0042813	Wnt-activated receptor activity	1/730	15/18367	0.455880216901257	0.688037068991017	LRP5	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/730	15/18367	0.455880216901257	0.688037068991017	CYBA	1
GO:0051139	metal ion:proton antiporter activity	1/730	15/18367	0.455880216901257	0.688037068991017	SLC9A1	1
GO:0051371	muscle alpha-actinin binding	1/730	15/18367	0.455880216901257	0.688037068991017	PDLIM2	1
GO:0070742	C2H2 zinc finger domain binding	1/730	15/18367	0.455880216901257	0.688037068991017	SRRM2	1
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	1/730	15/18367	0.455880216901257	0.688037068991017	CFLAR	1
GO:0099602	neurotransmitter receptor regulator activity	1/730	15/18367	0.455880216901257	0.688037068991017	LY6E	1
GO:1904680	peptide transmembrane transporter activity	1/730	15/18367	0.455880216901257	0.688037068991017	GJA1	1
GO:0019787	ubiquitin-like protein transferase activity	19/730	458/18367	0.457346393907621	0.688037068991017	NEURL1/CBX4/RNF43/ZNRF3/MYCBP2/TRIM44/ZNF451/MIB1/UFL1/MDM2/BIRC6/RANBP2/HUWE1/CDC42/TTC3/MYLIP/UBE2D3/UBE2A/CBLB	19
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/730	39/18367	0.462637175666722	0.688037068991017	POLR2J3/POLR2A	2
GO:0004402	histone acetyltransferase activity	2/730	39/18367	0.462637175666722	0.688037068991017	NCOA3/USP22	2
GO:0005504	fatty acid binding	2/730	39/18367	0.462637175666722	0.688037068991017	S100A9/ADH5	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/730	39/18367	0.462637175666722	0.688037068991017	IQGAP2/IQGAP1	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/730	39/18367	0.462637175666722	0.688037068991017	DLG1/AK3	2
GO:0032451	demethylase activity	2/730	39/18367	0.462637175666722	0.688037068991017	KDM5A/KDM5B	2
GO:0008276	protein methyltransferase activity	4/730	88/18367	0.465259191400002	0.688037068991017	KMT2C/DNMT3A/ASH1L/SETD2	4
GO:0015144	carbohydrate transmembrane transporter activity	2/730	40/18367	0.475845835380822	0.688037068991017	SLC2A8/SLC2A12	2
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/730	40/18367	0.475845835380822	0.688037068991017	CYP2J2/CYP19A1	2
GO:0017080	sodium channel regulator activity	2/730	40/18367	0.475845835380822	0.688037068991017	FXYD3/SGK1	2
GO:0042169	SH2 domain binding	2/730	40/18367	0.475845835380822	0.688037068991017	DAG1/GHR	2
GO:0043014	alpha-tubulin binding	2/730	40/18367	0.475845835380822	0.688037068991017	SETD2/ARL8B	2
GO:0003774	cytoskeletal motor activity	5/730	114/18367	0.476088744913774	0.688037068991017	MYH10/KIF5B/DYNC1H1/MYL6/DYNLRB1	5
GO:0003688	DNA replication origin binding	1/730	16/18367	0.477524040008389	0.688037068991017	HSPD1	1
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	1/730	16/18367	0.477524040008389	0.688037068991017	ADH5	1
GO:0004698	calcium-dependent protein kinase C activity	1/730	16/18367	0.477524040008389	0.688037068991017	PKN2	1
GO:0005283	amino acid:sodium symporter activity	1/730	16/18367	0.477524040008389	0.688037068991017	SLC38A1	1
GO:0005521	lamin binding	1/730	16/18367	0.477524040008389	0.688037068991017	BNIP3L	1
GO:0005523	tropomyosin binding	1/730	16/18367	0.477524040008389	0.688037068991017	S100A6	1
GO:0016004	phospholipase activator activity	1/730	16/18367	0.477524040008389	0.688037068991017	ARF1	1
GO:0016208	AMP binding	1/730	16/18367	0.477524040008389	0.688037068991017	ACSS1	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	1/730	16/18367	0.477524040008389	0.688037068991017	MAOA	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/730	16/18367	0.477524040008389	0.688037068991017	DICER1	1
GO:0017070	U6 snRNA binding	1/730	16/18367	0.477524040008389	0.688037068991017	EIF5A	1
GO:0022821	potassium ion antiporter activity	1/730	16/18367	0.477524040008389	0.688037068991017	SLC9A1	1
GO:0035173	histone kinase activity	1/730	16/18367	0.477524040008389	0.688037068991017	BAZ1B	1
GO:0035497	cAMP response element binding	1/730	16/18367	0.477524040008389	0.688037068991017	JUN	1
GO:0036122	BMP binding	1/730	16/18367	0.477524040008389	0.688037068991017	ENG	1
GO:0042577	lipid phosphatase activity	1/730	16/18367	0.477524040008389	0.688037068991017	PLPP3	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/730	16/18367	0.477524040008389	0.688037068991017	SOCS1	1
GO:0050700	CARD domain binding	1/730	16/18367	0.477524040008389	0.688037068991017	RIPK2	1
GO:0070403	NAD+ binding	1/730	16/18367	0.477524040008389	0.688037068991017	HADHA	1
GO:0140327	flippase activity	1/730	16/18367	0.477524040008389	0.688037068991017	ABCB1	1
GO:1990404	protein ADP-ribosylase activity	1/730	16/18367	0.477524040008389	0.688037068991017	PARP1	1
GO:0030145	manganese ion binding	3/730	65/18367	0.480631781415854	0.688951571527342	EXTL2/GLUL/ARG2	3
GO:0016874	ligase activity	7/730	165/18367	0.484727346961709	0.688951571527342	ACSS1/SLC27A2/IARS2/GLUL/RIMKLB/MDM2/UBA5	7
GO:0005543	phospholipid binding	19/730	466/18367	0.487988169424224	0.688951571527342	ANXA4/IQGAP2/HSPA8/ANXA1/PHLDA2/PSAP/NF1/SLC9A1/IQGAP1/ARHGAP32/SYT7/PFN1/MTSS1/EXOC1/NUMA1/SNX27/VAMP2/HMGB1/SDCBP	19
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/730	41/18367	0.488855040088374	0.688951571527342	COL14A1/COL4A2	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	2/730	41/18367	0.488855040088374	0.688951571527342	NCOA3/USP22	2
GO:0070851	growth factor receptor binding	6/730	141/18367	0.491283081628688	0.688951571527342	APP/EFEMP1/PGF/IL6ST/ARF4/SDCBP	6
GO:0016407	acetyltransferase activity	4/730	91/18367	0.491309928152159	0.688951571527342	NCOA3/USP22/HGSNAT/HADHA	4
GO:0004697	protein kinase C activity	1/730	17/18367	0.498308054546772	0.688951571527342	PKN2	1
GO:0005005	transmembrane-ephrin receptor activity	1/730	17/18367	0.498308054546772	0.688951571527342	EPHB4	1
GO:0005324	long-chain fatty acid transporter activity	1/730	17/18367	0.498308054546772	0.688951571527342	SLC27A2	1
GO:0008381	mechanosensitive ion channel activity	1/730	17/18367	0.498308054546772	0.688951571527342	TMEM150C	1
GO:0008392	arachidonic acid epoxygenase activity	1/730	17/18367	0.498308054546772	0.688951571527342	CYP2J2	1
GO:0008484	sulfuric ester hydrolase activity	1/730	17/18367	0.498308054546772	0.688951571527342	GNS	1
GO:0008525	phosphatidylcholine transporter activity	1/730	17/18367	0.498308054546772	0.688951571527342	ABCB1	1
GO:0008574	plus-end-directed microtubule motor activity	1/730	17/18367	0.498308054546772	0.688951571527342	KIF5B	1
GO:0009881	photoreceptor activity	1/730	17/18367	0.498308054546772	0.688951571527342	OPN3	1
GO:0015095	magnesium ion transmembrane transporter activity	1/730	17/18367	0.498308054546772	0.688951571527342	CNNM2	1
GO:0015108	chloride transmembrane transporter activity	1/730	17/18367	0.498308054546772	0.688951571527342	SLC26A2	1
GO:0015377	cation:chloride symporter activity	1/730	17/18367	0.498308054546772	0.688951571527342	SLC6A4	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/730	17/18367	0.498308054546772	0.688951571527342	FTH1	1
GO:0016854	racemase and epimerase activity	1/730	17/18367	0.498308054546772	0.688951571527342	GLCE	1
GO:0017081	chloride channel regulator activity	1/730	17/18367	0.498308054546772	0.688951571527342	SGK1	1
GO:0030169	low-density lipoprotein particle binding	1/730	17/18367	0.498308054546772	0.688951571527342	COLEC12	1
GO:0043395	heparan sulfate proteoglycan binding	1/730	17/18367	0.498308054546772	0.688951571527342	LRP1	1
GO:0046965	retinoid X receptor binding	1/730	17/18367	0.498308054546772	0.688951571527342	FUS	1
GO:0050780	dopamine receptor binding	1/730	17/18367	0.498308054546772	0.688951571527342	GNA12	1
GO:0003684	damaged DNA binding	3/730	68/18367	0.5108270507711	0.697032987082611	DDB1/TDG/HMGB1	3
GO:0008080	N-acetyltransferase activity	3/730	68/18367	0.5108270507711	0.697032987082611	NCOA3/USP22/HGSNAT	3
GO:0016782	transferase activity, transferring sulphur-containing groups	3/730	68/18367	0.5108270507711	0.697032987082611	TPST2/MOCS2/CHST12	3
GO:0030547	signaling receptor inhibitor activity	2/730	43/18367	0.514255697358249	0.697032987082611	LRPAP1/LY6E	2
GO:0034062	5'-3' RNA polymerase activity	2/730	43/18367	0.514255697358249	0.697032987082611	POLR2J3/POLR2A	2
GO:0097747	RNA polymerase activity	2/730	43/18367	0.514255697358249	0.697032987082611	POLR2J3/POLR2A	2
GO:0035091	phosphatidylinositol binding	11/730	271/18367	0.515079962452634	0.697032987082611	IQGAP2/PHLDA2/SLC9A1/IQGAP1/ARHGAP32/SYT7/PFN1/EXOC1/NUMA1/SNX27/SDCBP	11
GO:0016410	N-acyltransferase activity	4/730	94/18367	0.516818941060046	0.697032987082611	NMT1/NCOA3/USP22/HGSNAT	4
GO:0019001	guanyl nucleotide binding	16/730	398/18367	0.517700234456711	0.697032987082611	EEF1A1/GNA12/RHOA/GNAQ/RHOB/RALB/CDC42/HRAS/AK3/RHOBTB3/RAB11A/ARF4/RAB1A/RAC1/ARF1/ARL8B	16
GO:0032561	guanyl ribonucleotide binding	16/730	398/18367	0.517700234456711	0.697032987082611	EEF1A1/GNA12/RHOA/GNAQ/RHOB/RALB/CDC42/HRAS/AK3/RHOBTB3/RAB11A/ARF4/RAB1A/RAC1/ARF1/ARL8B	16
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/730	18/18367	0.518266371722841	0.697032987082611	HSD17B1	1
GO:0008569	minus-end-directed microtubule motor activity	1/730	18/18367	0.518266371722841	0.697032987082611	DYNC1H1	1
GO:0046624	sphingolipid transporter activity	1/730	18/18367	0.518266371722841	0.697032987082611	ABCB1	1
GO:0047834	D-threo-aldose 1-dehydrogenase activity	1/730	18/18367	0.518266371722841	0.697032987082611	AKR1B1	1
GO:0060229	lipase activator activity	1/730	18/18367	0.518266371722841	0.697032987082611	ARF1	1
GO:0070122	isopeptidase activity	1/730	18/18367	0.518266371722841	0.697032987082611	EIF3H	1
GO:0099095	ligand-gated anion channel activity	1/730	18/18367	0.518266371722841	0.697032987082611	GABRE	1
GO:0140597	protein carrier activity	1/730	18/18367	0.518266371722841	0.697032987082611	HSPA8	1
GO:0003777	microtubule motor activity	3/730	69/18367	0.520684989039918	0.699228029088349	KIF5B/DYNC1H1/DYNLRB1	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	9/730	222/18367	0.523763056716277	0.702300689925747	PRDX6/CROT/GLUL/NMT1/NCOA3/USP22/HGSNAT/HADHA/SPTSSA	9
GO:0051879	Hsp90 protein binding	2/730	44/18367	0.526639190385102	0.705093735319813	NR3C1/KPNB1	2
GO:0005179	hormone activity	5/730	122/18367	0.536217463772326	0.707532664706138	FBN1/IGF2/CSH1/APELA/INHA	5
GO:0016746	acyltransferase activity	10/730	250/18367	0.537261701895899	0.707532664706138	PRDX6/KMT2C/CROT/GLUL/NMT1/NCOA3/USP22/HGSNAT/HADHA/SPTSSA	10
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/730	19/18367	0.537431751233568	0.707532664706138	GALNT11	1
GO:0004745	NAD-retinol dehydrogenase activity	1/730	19/18367	0.537431751233568	0.707532664706138	RDH10	1
GO:0004890	GABA-A receptor activity	1/730	19/18367	0.537431751233568	0.707532664706138	GABRE	1
GO:0005003	ephrin receptor activity	1/730	19/18367	0.537431751233568	0.707532664706138	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/730	19/18367	0.537431751233568	0.707532664706138	SLC6A4	1
GO:0016918	retinal binding	1/730	19/18367	0.537431751233568	0.707532664706138	OPN3	1
GO:0035613	RNA stem-loop binding	1/730	19/18367	0.537431751233568	0.707532664706138	MYH10	1
GO:0052742	phosphatidylinositol kinase activity	1/730	19/18367	0.537431751233568	0.707532664706138	PIK3CB	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2/730	45/18367	0.538807214854956	0.707532664706138	BAZ1B/RIPK2	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/730	45/18367	0.538807214854956	0.707532664706138	DICER1/AGO2	2
GO:0048156	tau protein binding	2/730	45/18367	0.538807214854956	0.707532664706138	ROCK1/LGMN	2
GO:0004896	cytokine receptor activity	4/730	97/18367	0.541715606094793	0.710302616251137	CSF3R/LIFR/IL6ST/GHR	4
GO:0003730	mRNA 3'-UTR binding	8/730	201/18367	0.549027780036795	0.717456683746386	FUS/DDX5/DHX36/IGF2BP3/PUM1/LARP1/CPEB4/SECISBP2L	8
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	3/730	72/18367	0.549592802734858	0.717456683746386	COX6A1/CYB5A/UQCRH	3
GO:0030276	clathrin binding	3/730	72/18367	0.549592802734858	0.717456683746386	LRP1/CLTC/SYT7	3
GO:0140296	general transcription initiation factor binding	2/730	46/18367	0.550757317083669	0.717922661125194	EDF1/BDP1	2
GO:0031406	carboxylic acid binding	7/730	176/18367	0.553283317158121	0.71822368759729	SIGLEC6/S100A9/GLDC/NR2F2/PSAP/GLUL/ADH5	7
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/730	20/18367	0.55583565474346	0.71822368759729	EDF1	1
GO:0001972	retinoic acid binding	1/730	20/18367	0.55583565474346	0.71822368759729	NR2F2	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/730	20/18367	0.55583565474346	0.71822368759729	CTSC	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/730	20/18367	0.55583565474346	0.71822368759729	SOCS1	1
GO:0050145	nucleoside monophosphate kinase activity	1/730	20/18367	0.55583565474346	0.71822368759729	DLG1	1
GO:0140104	molecular carrier activity	3/730	73/18367	0.558997801721141	0.721261314557466	HSPA8/TNPO1/KPNB1	3
GO:0005044	scavenger receptor activity	2/730	47/18367	0.562487577842663	0.723663468454599	LRP1/COLEC12	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/730	47/18367	0.562487577842663	0.723663468454599	ADRB1/GABRE	2
GO:0015081	sodium ion transmembrane transporter activity	6/730	152/18367	0.564979867517339	0.725819511882824	SLC6A8/SLC38A1/SLC13A4/SLC6A4/SLC9A1/SLC20A1	6
GO:0005385	zinc ion transmembrane transporter activity	1/730	21/18367	0.573508297248352	0.730018532417021	SLC39A10	1
GO:0008391	arachidonic acid monooxygenase activity	1/730	21/18367	0.573508297248352	0.730018532417021	CYP2J2	1
GO:0015662	P-type ion transporter activity	1/730	21/18367	0.573508297248352	0.730018532417021	ATP2B1	1
GO:0019200	carbohydrate kinase activity	1/730	21/18367	0.573508297248352	0.730018532417021	NAGK	1
GO:0140358	P-type transmembrane transporter activity	1/730	21/18367	0.573508297248352	0.730018532417021	ATP2B1	1
GO:1990381	ubiquitin-specific protease binding	1/730	21/18367	0.573508297248352	0.730018532417021	CLTC	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/730	48/18367	0.573996573857703	0.730018532417021	GLUL/RIMKLB	2
GO:0032813	tumor necrosis factor receptor superfamily binding	2/730	49/18367	0.585283341516938	0.734188132610469	CFLAR/TMBIM1	2
GO:0034212	peptide N-acetyltransferase activity	2/730	49/18367	0.585283341516938	0.734188132610469	NCOA3/USP22	2
GO:0031490	chromatin DNA binding	4/730	103/18367	0.589441992201919	0.734188132610469	HMGN3/CHD4/ZFX/MBD3	4
GO:0005416	amino acid:cation symporter activity	1/730	22/18367	0.590478696409407	0.734188132610469	SLC38A1	1
GO:0008320	protein transmembrane transporter activity	1/730	22/18367	0.590478696409407	0.734188132610469	SEC61G	1
GO:0015106	bicarbonate transmembrane transporter activity	1/730	22/18367	0.590478696409407	0.734188132610469	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/730	22/18367	0.590478696409407	0.734188132610469	SLC27A2	1
GO:0016917	GABA receptor activity	1/730	22/18367	0.590478696409407	0.734188132610469	GABRE	1
GO:0030021	extracellular matrix structural constituent conferring compression resistance	1/730	22/18367	0.590478696409407	0.734188132610469	BGN	1
GO:0030742	GTP-dependent protein binding	1/730	22/18367	0.590478696409407	0.734188132610469	CDC42	1
GO:0033691	sialic acid binding	1/730	22/18367	0.590478696409407	0.734188132610469	SIGLEC6	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/730	22/18367	0.590478696409407	0.734188132610469	SERPINB9	1
GO:0050321	tau-protein kinase activity	1/730	22/18367	0.590478696409407	0.734188132610469	ROCK1	1
GO:0055106	ubiquitin-protein transferase regulator activity	1/730	22/18367	0.590478696409407	0.734188132610469	RPS20	1
GO:0070182	DNA polymerase binding	1/730	22/18367	0.590478696409407	0.734188132610469	HMGB1	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	6/730	156/18367	0.590488768072537	0.734188132610469	KMT2C/DNMT3A/ASH1L/CMTR1/DNMT1/SETD2	6
GO:0003724	RNA helicase activity	3/730	77/18367	0.595405384516033	0.738374356040378	DDX5/DHX36/DDX17	3
GO:0030159	signaling receptor complex adaptor activity	2/730	50/18367	0.596347342673781	0.738374356040378	DLG5/SPAG9	2
GO:0140359	ABC-type transporter activity	2/730	50/18367	0.596347342673781	0.738374356040378	ABCB1/ATP13A3	2
GO:0016779	nucleotidyltransferase activity	5/730	132/18367	0.606571142578845	0.743006509675418	UGP2/NANS/POLR2J3/CDS1/POLR2A	5
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/730	23/18367	0.606774719937405	0.743006509675418	PARP1	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/730	23/18367	0.606774719937405	0.743006509675418	PDE4B	1
GO:0005158	insulin receptor binding	1/730	23/18367	0.606774719937405	0.743006509675418	IGF2	1
GO:0008143	poly(A) binding	1/730	23/18367	0.606774719937405	0.743006509675418	HNRNPDL	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/730	23/18367	0.606774719937405	0.743006509675418	PKN2	1
GO:0015299	solute:proton antiporter activity	1/730	23/18367	0.606774719937405	0.743006509675418	SLC9A1	1
GO:0030552	cAMP binding	1/730	23/18367	0.606774719937405	0.743006509675418	PDE4B	1
GO:0008186	ATP-dependent activity, acting on RNA	3/730	79/18367	0.61285882663342	0.749424342334402	DDX5/DHX36/DDX17	3
GO:0008146	sulfotransferase activity	2/730	52/18367	0.617806828836191	0.752370234021059	TPST2/CHST12	2
GO:0016597	amino acid binding	2/730	52/18367	0.617806828836191	0.752370234021059	GLDC/GLUL	2
GO:0016830	carbon-carbon lyase activity	2/730	52/18367	0.617806828836191	0.752370234021059	ALDOA/PISD	2
GO:0008171	O-methyltransferase activity	1/730	24/18367	0.62242313110431	0.753861258244866	CMTR1	1
GO:0010857	calcium-dependent protein kinase activity	1/730	24/18367	0.62242313110431	0.753861258244866	PKN2	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/730	24/18367	0.62242313110431	0.753861258244866	GAPDH	1
GO:0051537	2 iron, 2 sulfur cluster binding	1/730	24/18367	0.62242313110431	0.753861258244866	FDX1	1
GO:0017069	snRNA binding	2/730	53/18367	0.62820308428914	0.757764643057049	EIF5A/SNU13	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	2/730	53/18367	0.62820308428914	0.757764643057049	SLC29A3/SLC35B4	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/730	53/18367	0.62820308428914	0.757764643057049	SLC6A4/SLC16A3	2
GO:0008237	metallopeptidase activity	7/730	190/18367	0.634213775630419	0.762708914203734	ADAMTS6/TFRC/ADAM12/ENPEP/ADAMTS1/AFG3L2/EIF3H	7
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/730	25/18367	0.637449632455989	0.762708914203734	PDE4B	1
GO:0005227	calcium activated cation channel activity	1/730	25/18367	0.637449632455989	0.762708914203734	KCNN4	1
GO:0008266	poly(U) RNA binding	1/730	25/18367	0.637449632455989	0.762708914203734	MSI2	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	1/730	25/18367	0.637449632455989	0.762708914203734	DHX36	1
GO:0070330	aromatase activity	1/730	25/18367	0.637449632455989	0.762708914203734	CYP19A1	1
GO:0008374	O-acyltransferase activity	2/730	54/18367	0.638378058735932	0.762793137387424	PRDX6/CROT	2
GO:0005126	cytokine receptor binding	10/730	271/18367	0.639673093112864	0.763314603727968	MIF/TGFBR3/LIFR/PGF/CSH1/IL6ST/CFLAR/ENG/TMBIM1/SDCBP	10
GO:0008047	enzyme activator activity	4/730	110/18367	0.641260475595943	0.764183060060045	CALM1/PSAP/CFLAR/ARF1	4
GO:0004222	metalloendopeptidase activity	4/730	111/18367	0.648303021151768	0.769615337359422	ADAMTS6/ADAM12/ADAMTS1/AFG3L2	4
GO:0004364	glutathione transferase activity	1/730	26/18367	0.651878907797126	0.769615337359422	GSTO1	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/730	26/18367	0.651878907797126	0.769615337359422	GLUL	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/730	26/18367	0.651878907797126	0.769615337359422	GLUL	1
GO:0038187	pattern recognition receptor activity	1/730	26/18367	0.651878907797126	0.769615337359422	COLEC12	1
GO:0042974	retinoic acid receptor binding	1/730	26/18367	0.651878907797126	0.769615337359422	FUS	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/730	26/18367	0.651878907797126	0.769615337359422	SLC26A2	1
GO:0001540	amyloid-beta binding	3/730	84/18367	0.654234980446323	0.771372543258331	LRP1/LRPAP1/ITM2B	3
GO:0004869	cysteine-type endopeptidase inhibitor activity	2/730	56/18367	0.658068992013055	0.774865342913386	SERPINB9/BIRC6	2
GO:0001671	ATPase activator activity	1/730	27/18367	0.665734662516503	0.77567249669354	DNAJB4	1
GO:0015215	nucleotide transmembrane transporter activity	1/730	27/18367	0.665734662516503	0.77567249669354	SLC25A36	1
GO:0015491	cation:cation antiporter activity	1/730	27/18367	0.665734662516503	0.77567249669354	SLC9A1	1
GO:0022884	macromolecule transmembrane transporter activity	1/730	27/18367	0.665734662516503	0.77567249669354	SEC61G	1
GO:0035255	ionotropic glutamate receptor binding	1/730	27/18367	0.665734662516503	0.77567249669354	FUS	1
GO:0043425	bHLH transcription factor binding	1/730	27/18367	0.665734662516503	0.77567249669354	ISL1	1
GO:0070006	metalloaminopeptidase activity	1/730	27/18367	0.665734662516503	0.77567249669354	ENPEP	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/730	27/18367	0.665734662516503	0.77567249669354	ABCB1	1
GO:0061630	ubiquitin protein ligase activity	11/730	304/18367	0.66753771772071	0.775798329226973	NEURL1/RNF43/ZNRF3/MYCBP2/TRIM44/MDM2/HUWE1/CDC42/MYLIP/UBE2D3/CBLB	11
GO:0004536	deoxyribonuclease activity	2/730	57/18367	0.66758798859239	0.775798329226973	RAD50/DICER1	2
GO:0008194	UDP-glycosyltransferase activity	5/730	143/18367	0.676381078128777	0.781951113731699	GALNT11/EXTL2/B3GNT2/HEXA/B3GAT3	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	2/730	58/18367	0.676891736425246	0.781951113731699	NANS/GSTO1	2
GO:0106310	protein serine kinase activity	13/730	360/18367	0.677750938725462	0.781951113731699	MAP3K4/AAK1/PNCK/PRKDC/NRK/STK17A/ROCK1/LATS2/PKN2/CAMK2G/NEK6/RIPK2/SGK1	13
GO:0008187	poly-pyrimidine tract binding	1/730	28/18367	0.679039662318191	0.781951113731699	MSI2	1
GO:0046875	ephrin receptor binding	1/730	28/18367	0.679039662318191	0.781951113731699	SDCBP	1
GO:0050681	androgen receptor binding	1/730	28/18367	0.679039662318191	0.781951113731699	DDX5	1
GO:0051861	glycolipid binding	1/730	28/18367	0.679039662318191	0.781951113731699	PSAP	1
GO:0030546	signaling receptor activator activity	18/730	495/18367	0.684851833023856	0.787623906284874	FBN1/IGF2/MIF/SEMA6D/APP/SEMA6A/EFEMP1/PGF/CSH1/GRN/LRPAP1/BMP7/APELA/CMTM8/INHA/SEMA4C/GDF15/HMGB1	18
GO:0015301	anion:anion antiporter activity	1/730	29/18367	0.691815770421562	0.792140473558987	SLC26A2	1
GO:0035250	UDP-galactosyltransferase activity	1/730	29/18367	0.691815770421562	0.792140473558987	B3GNT2	1
GO:0070717	poly-purine tract binding	1/730	29/18367	0.691815770421562	0.792140473558987	HNRNPDL	1
GO:0015297	antiporter activity	3/730	89/18367	0.692343248543681	0.792140473558987	SLC26A2/SLC7A6/SLC9A1	3
GO:0005507	copper ion binding	2/730	61/18367	0.703532835677775	0.80144770953308	F5/SOD3	2
GO:0005310	dicarboxylic acid transmembrane transporter activity	1/730	30/18367	0.704083983290591	0.80144770953308	SLC26A2	1
GO:0005343	organic acid:sodium symporter activity	1/730	30/18367	0.704083983290591	0.80144770953308	SLC38A1	1
GO:0016417	S-acyltransferase activity	1/730	30/18367	0.704083983290591	0.80144770953308	GLUL	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/730	62/18367	0.711997754802179	0.809419442479715	ADRB1/GABRE	2
GO:0031210	phosphatidylcholine binding	1/730	31/18367	0.715864464950506	0.810134005910195	NF1	1
GO:0042910	xenobiotic transmembrane transporter activity	1/730	31/18367	0.715864464950506	0.810134005910195	ABCB1	1
GO:0043015	gamma-tubulin binding	1/730	31/18367	0.715864464950506	0.810134005910195	PDE4B	1
GO:0140677	molecular function activator activity	5/730	150/18367	0.716271460793491	0.810134005910195	CALM1/PSAP/DNAJB4/CFLAR/ARF1	5
GO:0072341	modified amino acid binding	3/730	93/18367	0.7204855376202	0.813864857616719	HSPA8/SYT7/HMGB1	3
GO:0001222	transcription corepressor binding	1/730	32/18367	0.727176579947568	0.816237347946197	NEK6	1
GO:0001223	transcription coactivator binding	1/730	32/18367	0.727176579947568	0.816237347946197	TFAM	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/730	32/18367	0.727176579947568	0.816237347946197	SLC25A36	1
GO:0030332	cyclin binding	1/730	32/18367	0.727176579947568	0.816237347946197	CDKN1A	1
GO:0048019	receptor antagonist activity	1/730	32/18367	0.727176579947568	0.816237347946197	LRPAP1	1
GO:0004623	phospholipase A2 activity	1/730	33/18367	0.73803892500556	0.825303904817538	PRDX6	1
GO:0051427	hormone receptor binding	1/730	33/18367	0.73803892500556	0.825303904817538	CSH1	1
GO:0140323	solute:anion antiporter activity	1/730	33/18367	0.73803892500556	0.825303904817538	SLC26A2	1
GO:0048018	receptor ligand activity	17/730	487/18367	0.742926397314621	0.829420787443738	FBN1/IGF2/MIF/SEMA6D/SEMA6A/EFEMP1/PGF/CSH1/GRN/LRPAP1/BMP7/APELA/CMTM8/INHA/SEMA4C/GDF15/HMGB1	17
GO:0004842	ubiquitin-protein transferase activity	15/730	433/18367	0.743586465233587	0.829420787443738	NEURL1/RNF43/ZNRF3/MYCBP2/TRIM44/MIB1/MDM2/BIRC6/HUWE1/CDC42/TTC3/MYLIP/UBE2D3/UBE2A/CBLB	15
GO:0008170	N-methyltransferase activity	3/730	97/18367	0.746584521500411	0.830698202913446	KMT2C/ASH1L/SETD2	3
GO:0015020	glucuronosyltransferase activity	1/730	34/18367	0.74846935943045	0.830698202913446	B3GAT3	1
GO:0016831	carboxy-lyase activity	1/730	34/18367	0.74846935943045	0.830698202913446	PISD	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/730	34/18367	0.74846935943045	0.830698202913446	CALM1	1
GO:0008168	methyltransferase activity	7/730	214/18367	0.751364069607027	0.832871144489585	KMT2C/DNMT3A/ASH1L/MTR/CMTR1/DNMT1/SETD2	7
GO:0015298	solute:cation antiporter activity	1/730	35/18367	0.758485034312672	0.838305795257171	SLC9A1	1
GO:0042887	amide transmembrane transporter activity	1/730	35/18367	0.758485034312672	0.838305795257171	GJA1	1
GO:0004519	endonuclease activity	4/730	129/18367	0.759095798854919	0.838305795257171	N4BP2/RAD50/DICER1/AGO2	4
GO:0004521	endoribonuclease activity	2/730	69/18367	0.765718499355982	0.844570404376511	DICER1/AGO2	2
GO:0005484	SNAP receptor activity	1/730	36/18367	0.768102420574496	0.846150002342908	VAMP2	1
GO:0004497	monooxygenase activity	3/730	102/18367	0.776427590351176	0.851050359140784	CYP2J2/CYP11A1/CYP19A1	3
GO:0030551	cyclic nucleotide binding	1/730	37/18367	0.777337335908118	0.851050359140784	PDE4B	1
GO:0043531	ADP binding	1/730	37/18367	0.777337335908118	0.851050359140784	MYH10	1
GO:0046915	transition metal ion transmembrane transporter activity	1/730	37/18367	0.777337335908118	0.851050359140784	SLC39A10	1
GO:0071855	neuropeptide receptor binding	1/730	37/18367	0.777337335908118	0.851050359140784	APELA	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	2/730	71/18367	0.779379737101904	0.852236883497654	CAT/HINT1	2
GO:0000049	tRNA binding	2/730	72/18367	0.78594507808382	0.856539483953818	EEF1A1/IARS2	2
GO:0008235	metalloexopeptidase activity	2/730	72/18367	0.78594507808382	0.856539483953818	TFRC/ENPEP	2
GO:0140303	intramembrane lipid transporter activity	1/730	38/18367	0.786204970648274	0.856539483953818	ABCB1	1
GO:0005085	guanyl-nucleotide exchange factor activity	7/730	223/18367	0.78764597385551	0.857059082934576	ADRB1/EEF1B2/EPS8L1/MYCBP2/NUCB2/NET1/ARF4	7
GO:0043177	organic acid binding	4/730	135/18367	0.789392883681339	0.857909869917739	S100A9/GLDC/NR2F2/GLUL	4
GO:1990782	protein tyrosine kinase binding	3/730	105/18367	0.792907791969844	0.859955765121026	ITGB1/PTPN14/CBLB	3
GO:0019825	oxygen binding	1/730	39/18367	0.794719912621473	0.859955765121026	CYP19A1	1
GO:0050997	quaternary ammonium group binding	1/730	39/18367	0.794719912621473	0.859955765121026	NF1	1
GO:0016741	transferase activity, transferring one-carbon groups	7/730	225/18367	0.79514470070808	0.859955765121026	KMT2C/DNMT3A/ASH1L/MTR/CMTR1/DNMT1/SETD2	7
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/730	40/18367	0.802896171012259	0.867283956293922	SERPINB9	1
GO:0004812	aminoacyl-tRNA ligase activity	1/730	41/18367	0.810747199285356	0.872583850078307	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/730	41/18367	0.810747199285356	0.872583850078307	IARS2	1
GO:0048487	beta-tubulin binding	1/730	41/18367	0.810747199285356	0.872583850078307	ARL8B	1
GO:0030971	receptor tyrosine kinase binding	2/730	78/18367	0.821831702185688	0.883444236085945	PTPN14/CBLB	2
GO:0030544	Hsp70 protein binding	1/730	43/18367	0.825524731959138	0.885273204718545	DNAJB14	1
GO:0032266	phosphatidylinositol-3-phosphate binding	1/730	43/18367	0.825524731959138	0.885273204718545	SNX27	1
GO:0140375	immune receptor activity	4/730	144/18367	0.829033560269941	0.887375025795028	CSF3R/LIFR/IL6ST/GHR	4
GO:0005125	cytokine activity	7/730	235/18367	0.829653268431134	0.887375025795028	MIF/GRN/BMP7/CMTM8/INHA/GDF15/HMGB1	7
GO:0004712	protein serine/threonine/tyrosine kinase activity	1/730	44/18367	0.832475558507372	0.887375025795028	SGK1	1
GO:0022839	ion gated channel activity	1/730	44/18367	0.832475558507372	0.887375025795028	KCNN4	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/730	44/18367	0.832475558507372	0.887375025795028	GABRE	1
GO:0005245	voltage-gated calcium channel activity	1/730	45/18367	0.839149839044927	0.893418211869389	ITGAV	1
GO:0070888	E-box binding	1/730	48/18367	0.85762112358269	0.911991840747622	HES1	1
GO:0015485	cholesterol binding	1/730	50/18367	0.868742735226787	0.921613713146317	CAV1	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/730	50/18367	0.868742735226787	0.921613713146317	TDG	1
GO:0008081	phosphoric diester hydrolase activity	2/730	89/18367	0.873859676213332	0.924955627524092	PDE4B/GPCPD1	2
GO:0008227	G protein-coupled amine receptor activity	1/730	51/18367	0.873973821282607	0.924955627524092	ADRB1	1
GO:0004175	endopeptidase activity	13/730	430/18367	0.877398859228072	0.925862641469588	ADAMTS6/HTRA4/ADAM12/CTSC/CTSL/CTSV/ADAMTS1/USP10/AFG3L2/LGMN/USP48/USP9X/CFLAR	13
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3/730	125/18367	0.878603997542256	0.925862641469588	CAT/HINT1/ARG2	3
GO:0017046	peptide hormone binding	1/730	52/18367	0.878996703487438	0.925862641469588	GHR	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/730	52/18367	0.878996703487438	0.925862641469588	AGL	1
GO:0008408	3'-5' exonuclease activity	1/730	54/18367	0.888450631268203	0.934713149346074	RAD50	1
GO:0030170	pyridoxal phosphate binding	1/730	55/18367	0.892897256025163	0.938280922702565	GLDC	1
GO:0070279	vitamin B6 binding	1/730	56/18367	0.897166860825383	0.941654473758873	GLDC	1
GO:0005548	phospholipid transporter activity	1/730	57/18367	0.901266483543829	0.944841867771774	ABCB1	1
GO:0015085	calcium ion transmembrane transporter activity	3/730	135/18367	0.908294627680659	0.951088249715083	ATP2B1/ITGAV/TMEM37	3
GO:0022824	transmitter-gated ion channel activity	1/730	60/18367	0.912611712411693	0.952243911190135	GABRE	1
GO:0022835	transmitter-gated channel activity	1/730	60/18367	0.912611712411693	0.952243911190135	GABRE	1
GO:0032934	sterol binding	1/730	60/18367	0.912611712411693	0.952243911190135	CAV1	1
GO:0046873	metal ion transmembrane transporter activity	12/730	430/18367	0.925091658310746	0.964134213643907	ATP2B1/ITGAV/SLC39A10/KCNN4/SLC6A8/SLC38A1/SLC13A4/TMEM37/SLC6A4/SLC9A1/CNNM2/SLC20A1	12
GO:0008173	RNA methyltransferase activity	1/730	65/18367	0.928701362435056	0.966762893682395	CMTR1	1
GO:0052689	carboxylic ester hydrolase activity	3/730	147/18367	0.935154077581822	0.970883869935086	PRDX6/APMAP/IARS2	3
GO:0051536	iron-sulfur cluster binding	1/730	68/18367	0.936897552506147	0.970883869935086	FDX1	1
GO:0051540	metal cluster binding	1/730	68/18367	0.936897552506147	0.970883869935086	FDX1	1
GO:0019842	vitamin binding	3/730	148/18367	0.937028526888981	0.970883869935086	GLDC/OPN3/MTR	3
GO:0030594	neurotransmitter receptor activity	2/730	111/18367	0.93849920988953	0.971275666579502	ADRB1/GABRE	2
GO:0004540	ribonuclease activity	2/730	116/18367	0.947982135849019	0.978230483905346	DICER1/AGO2	2
GO:0008236	serine-type peptidase activity	4/730	191/18367	0.948516733397408	0.978230483905346	HTRA4/CTSC/CTSV/DPP7	4
GO:0005230	extracellular ligand-gated ion channel activity	1/730	73/18367	0.94852044671137	0.978230483905346	GABRE	1
GO:0005262	calcium channel activity	2/730	119/18367	0.952985056217785	0.981448785049704	ITGAV/TMEM37	2
GO:0017171	serine hydrolase activity	4/730	195/18367	0.95384898794482	0.981448785049704	HTRA4/CTSC/CTSV/DPP7	4
GO:0005244	voltage-gated ion channel activity	4/730	201/18367	0.960900146657889	0.985683129911176	CLIC3/ITGAV/TMEM37/CLIC1	4
GO:0022832	voltage-gated channel activity	4/730	201/18367	0.960900146657889	0.985683129911176	CLIC3/ITGAV/TMEM37/CLIC1	4
GO:0004527	exonuclease activity	1/730	80/18367	0.961290521521923	0.985683129911176	RAD50	1
GO:0004518	nuclease activity	4/730	210/18367	0.969626225151145	0.989876294685457	N4BP2/RAD50/DICER1/AGO2	4
GO:0015267	channel activity	12/730	480/18367	0.970687606690231	0.989876294685457	CLIC3/FXYD3/ITGAV/TMEM150C/GJA1/GABRE/KCNN4/TMEM37/GJA5/BCL2/CLDN4/CLIC1	12
GO:0004252	serine-type endopeptidase activity	3/730	174/18367	0.971248036137433	0.989876294685457	HTRA4/CTSC/CTSV	3
GO:0022803	passive transmembrane transporter activity	12/730	481/18367	0.971263937959873	0.989876294685457	CLIC3/FXYD3/ITGAV/TMEM150C/GJA1/GABRE/KCNN4/TMEM37/GJA5/BCL2/CLDN4/CLIC1	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/730	88/18367	0.972058326221882	0.989876294685457	CYBA	1
GO:0140098	catalytic activity, acting on RNA	9/730	386/18367	0.972297336611311	0.989876294685457	DDX5/IARS2/DHX36/POLR2J3/DICER1/CMTR1/DDX17/POLR2A/AGO2	9
GO:0043178	alcohol binding	1/730	89/18367	0.973174219971979	0.989876294685457	CAV1	1
GO:0008528	G protein-coupled peptide receptor activity	2/730	147/18367	0.982066806120877	0.99654954732391	LGR5/LGR4	2
GO:0022836	gated channel activity	7/730	340/18367	0.983327997783073	0.99654954732391	CLIC3/ITGAV/TMEM150C/GABRE/KCNN4/TMEM37/CLIC1	7
GO:0004620	phospholipase activity	1/730	104/18367	0.985447660845314	0.99654954732391	PRDX6	1
GO:0001653	peptide receptor activity	2/730	153/18367	0.985472170084967	0.99654954732391	LGR5/LGR4	2
GO:0005319	lipid transporter activity	2/730	154/18367	0.985974927822846	0.99654954732391	SLC27A2/ABCB1	2
GO:0015079	potassium ion transmembrane transporter activity	2/730	155/18367	0.986460744257639	0.99654954732391	KCNN4/SLC9A1	2
GO:0005216	ion channel activity	9/730	432/18367	0.990381943913094	0.99816288277226	CLIC3/FXYD3/ITGAV/TMEM150C/GABRE/KCNN4/TMEM37/CLDN4/CLIC1	9
GO:0003823	antigen binding	2/730	171/18367	0.992330778179454	0.99816288277226	DHCR24/SLC7A5	2
GO:0005267	potassium channel activity	1/730	121/18367	0.992728433098503	0.99816288277226	KCNN4	1
GO:0140101	catalytic activity, acting on a tRNA	1/730	124/18367	0.993566803367844	0.99816288277226	IARS2	1
GO:0016298	lipase activity	1/730	129/18367	0.994755086274679	0.99816288277226	PRDX6	1
GO:0015276	ligand-gated ion channel activity	1/730	143/18367	0.997040089878253	0.99816288277226	GABRE	1
GO:0022834	ligand-gated channel activity	1/730	143/18367	0.997040089878253	0.99816288277226	GABRE	1
GO:0022843	voltage-gated cation channel activity	1/730	143/18367	0.997040089878253	0.99816288277226	ITGAV	1
GO:0005261	cation channel activity	3/730	335/18367	0.999873205142162	0.999873205142162	ITGAV/KCNN4/TMEM37	3