ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0002181 cytoplasmic translation 52/725 148/18722 6.2053090334012e-36 3.14547114903107e-32 RPLP0/RPL24/RPS13/RPL19/RPS3A/RPL23A/RPS21/EIF4H/PKM/RPL14/RPL18A/RPL8/RPS10/RPS6/RPL4/RPL6/RPLP1/RPL13/RPL29/RPS16/RPS12/RPS8/RPL15/RPS25/UBA52/RPS2/RPL28/RPL10/RPL26/RPS19/RPL9/RPL13A/RPS11/RPL32/RPS26/DHX36/RPS5/RPL10A/RPL22/RPL3/RPL27A/EIF2S2/RPS20/RPL12/RPL7A/CPEB4/RPL7/RPL17/RPL27/EIF3H/EIF3I/RPSA 52 GO:0048608 reproductive structure development 49/725 424/18722 7.93929743219053e-12 1.73436791027719e-08 KRT19/KRT8/SPINT1/IGF2/BASP1/ADGRG1/MAP3K4/LGR4/LRP2/DHCR24/SF1/GJA1/RPS6/TBX3/ANXA1/NR2F2/RBPJ/FSTL3/PHLDA2/NASP/IDH1/GLI3/PSAP/BMP7/CTSV/HSPA5/BPTF/ATRX/ADAMTS1/ASH1L/TFEB/RDH10/BCL2/CEBPB/APELA/ARID5B/DLG1/EIF2S2/NIPBL/KDM5A/BIRC6/SERPINF1/INHA/RHOBTB3/HES1/KDM5B/SETD2/ZFX/CYP19A1 49 GO:0061458 reproductive system development 49/725 427/18722 1.02645565808475e-11 1.73436791027719e-08 KRT19/KRT8/SPINT1/IGF2/BASP1/ADGRG1/MAP3K4/LGR4/LRP2/DHCR24/SF1/GJA1/RPS6/TBX3/ANXA1/NR2F2/RBPJ/FSTL3/PHLDA2/NASP/IDH1/GLI3/PSAP/BMP7/CTSV/HSPA5/BPTF/ATRX/ADAMTS1/ASH1L/TFEB/RDH10/BCL2/CEBPB/APELA/ARID5B/DLG1/EIF2S2/NIPBL/KDM5A/BIRC6/SERPINF1/INHA/RHOBTB3/HES1/KDM5B/SETD2/ZFX/CYP19A1 49 GO:0001667 ameboidal-type cell migration 50/725 475/18722 1.43445445149821e-10 1.61242275425885e-07 SYDE1/NRP2/ITGB1/ITGB4/KANK1/SEMA6D/SEMA6A/PLPP3/EPHB4/GJA1/LAMA5/ANXA1/MET/NR2F2/MACF1/ISL1/GNA12/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/LRP5/NF1/GLUL/HSPB1/BMP7/GPC3/S100P/CSNK2B/ROCK1/WASF2/LGMN/PKN2/APELA/ARID5B/PLEC/RHOB/PFN1/SERPINF1/SASH1/AGO2/AMOT/TACSTD2/SEMA4C/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 50 GO:0072001 renal system development 38/725 302/18722 1.59047421015866e-10 1.61242275425885e-07 FBN1/ADAMTS6/DLG5/BASP1/LGR5/LGR4/LRP2/AKR1B1/MAGED1/LAMA5/C1GALT1/FSTL3/ENPEP/SOX4/GLI3/PBX1/RHOA/NF1/BMP7/GPC3/ADAMTS1/FRAS1/IRX2/RDH10/BCL2/ARID5B/DLG1/IQGAP1/CAT/NIPBL/MTSS1/SERPINF1/TFAP2A/HES1/TACSTD2/CFLAR/CENPF/ARG2 38 GO:0001822 kidney development 37/725 293/18722 2.50710337735454e-10 2.11808450330169e-07 FBN1/ADAMTS6/DLG5/BASP1/LGR4/LRP2/AKR1B1/MAGED1/LAMA5/C1GALT1/FSTL3/ENPEP/SOX4/GLI3/PBX1/RHOA/NF1/BMP7/GPC3/ADAMTS1/FRAS1/IRX2/RDH10/BCL2/ARID5B/DLG1/IQGAP1/CAT/NIPBL/MTSS1/SERPINF1/TFAP2A/HES1/TACSTD2/CFLAR/CENPF/ARG2 37 GO:0001655 urogenital system development 40/725 338/18722 3.3915754173998e-10 2.45598511297137e-07 FBN1/ADAMTS6/DLG5/BASP1/LGR5/LGR4/LRP2/AKR1B1/MAGED1/LAMA5/ANXA1/C1GALT1/FSTL3/ENPEP/SOX4/GLI3/PBX1/RHOA/PSAP/NF1/BMP7/GPC3/ADAMTS1/FRAS1/IRX2/RDH10/BCL2/ARID5B/DLG1/IQGAP1/CAT/NIPBL/MTSS1/SERPINF1/TFAP2A/HES1/TACSTD2/CFLAR/CENPF/ARG2 40 GO:0048545 response to steroid hormone 37/725 339/18722 1.42849356769328e-08 8.7059732048366e-06 ATP2B1/CAV1/FOS/AGL/HSPD1/DUSP1/EGFR/FOSB/DDX5/ANXA1/CALM1/ISL1/PARP1/TXNIP/IDH1/RHOA/BMP7/CTSV/ESRRA/BCL2/CLDN4/GHR/UFL1/MDM2/NR3C1/DDX17/HSD3B1/UBA5/SERPINF1/RPL27/CDKN1A/NCOA2/CFLAR/HMGB1/ESRRG/ENG/CYBA 37 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 38/725 355/18722 1.54574391090017e-08 8.7059732048366e-06 PEG10/FBN1/FBN2/CAV1/LRP1/HTRA4/FOS/LRP2/JUN/GLG1/TGFBR3/DDX5/PDCD4/PARP1/RBPJ/FSTL3/CRIM1/BMP7/GPC3/HSPA5/ZNF451/LTBP1/CSNK2B/NREP/LATS2/FUT8/HSPA1A/INHA/HES1/NUMA1/USP9X/CDKN1C/GDF15/UBE2D3/SUB1/ZNF703/ENG/SDCBP 38 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 31/725 256/18722 1.95548581778335e-08 9.9123576103438e-06 PEG10/FBN1/FBN2/CAV1/LRP1/HTRA4/LRP2/GLG1/TGFBR3/PARP1/RBPJ/FSTL3/CRIM1/BMP7/GPC3/HSPA5/ZNF451/LTBP1/CSNK2B/NREP/LATS2/HSPA1A/INHA/HES1/NUMA1/CDKN1C/GDF15/UBE2D3/ZNF703/ENG/SDCBP 31 GO:0031960 response to corticosteroid 24/725 167/18722 2.99170880360667e-08 1.37863381140747e-05 ATP2B1/FOS/AGL/HSPD1/DUSP1/EGFR/FOSB/ANXA1/CALM1/ISL1/PARP1/RHOA/CTSV/BCL2/GHR/NR3C1/HSD3B1/SERPINF1/RPL27/CDKN1A/CFLAR/HMGB1/ENG/CYBA 24 GO:0007568 aging 36/725 339/18722 4.54192033367544e-08 1.91858284761673e-05 ATP2B1/LRP1/FOS/MIF/APP/DAG1/JUN/JUND/CTSC/PRKDC/TBX3/PDCD4/NFE2L2/DNMT3A/PPP1R9A/NPM1/RPN2/CTSV/TFCP2L1/YPEL3/BCL2/GPX4/COL4A2/CAT/SERPINF1/ERO1A/HRAS/NEK6/CDKN1A/SERP1/SERPINE1/MBD3/TIMP2/ARG2/B2M/YBX1 36 GO:0060562 epithelial tube morphogenesis 35/725 325/18722 4.92798463250167e-08 1.92153493093469e-05 SPINT1/DLG5/LGR5/LGR4/LRP2/DAG1/MAGED1/LAMA5/TBX3/MET/RBPJ/SOX4/GLI3/PBX1/RHOA/LRP5/BMP7/GPC3/COBL/MIB1/CSNK2B/IRX2/RDH10/BCL2/DLG1/RHOB/PFN1/MTSS1/BRD2/HES1/KDM5B/SETD2/TACSTD2/SEMA4C/ENG 35 GO:0048732 gland development 42/725 436/18722 5.7354377273846e-08 2.07663813143661e-05 WLS/CAV1/IGF2/RPL19/DAG1/KRT18/TGFBR3/PRKDC/EGFR/CDH1/LAMA5/TBX3/ANXA1/MET/NEURL1/RPS16/ISL1/RBPJ/FSTL3/GLI3/PBX1/LRP5/PSAP/NF1/BMP7/COBL/ASH1L/CSNK2B/TFCP2L1/BCL2/CEBPB/ARID5B/SERPINF1/CDC42/HRAS/UPF2/LY6E/HES1/KDM5B/RTN4/CFLAR/ZNF703 42 GO:0051222 positive regulation of protein transport 33/725 303/18722 9.11145565097164e-08 3.07906457965168e-05 TCAF1/DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/CDH1/KCNN4/STOM/ISL1/EZR/SOX4/GLI3/GLUL/OAZ1/NMT1/B3GAT3/MDM2/MPC2/EXOC1/HUWE1/CDC42/HRAS/VAMP2/UBE2D3/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 33 GO:0007517 muscle organ development 34/725 327/18722 1.78477998885658e-07 5.45832602302643e-05 CAV1/IGF2/BASP1/FOS/UTRN/LRP2/DAG1/TGFBR3/DDX5/LAMA5/NEURL1/NR2F2/BTG2/ISL1/RBPJ/ZFHX3/RHOA/HMG20B/MYL6/HOMER1/BCL2/ARID5B/PLEC/GPCPD1/FLNB/DDX17/LY6E/ZNF609/CFLAR/SRI/SERP1/CENPF/ENG/ATF3 34 GO:0042060 wound healing 40/725 422/18722 1.83056899568848e-07 5.45832602302643e-05 F5/CAV1/ITGB1/FBLN1/KANK1/DAG1/PLPP3/EGFR/GJA1/DST/ANXA1/LMAN1/MACF1/TFPI2/GNA12/NFE2L2/GLI3/IL6ST/RHOA/NF1/HSPB1/ACTG1/GNAQ/CLDN4/PLEC/PHLDB2/SYT7/C1QTNF1/SRSF6/HRAS/AK3/CDKN1A/CFLAR/HMGB1/CLIC1/SERPINB2/SERPINE1/PIK3CB/PPIA/ARL8B 40 GO:0043484 regulation of RNA splicing 21/725 148/18722 2.70626768023199e-07 7.62115048394221e-05 PRDX6/SON/RPS13/FUS/RBM39/HSPA8/SF1/DDX5/SAP18/NPM1/RBM25/RPS26/SRSF9/TRA2B/SRSF7/HSPA1A/HNRNPA1/DDX17/QKI/SRSF6/POLR2A 21 GO:1904951 positive regulation of establishment of protein localization 33/725 319/18722 3.04182691006642e-07 7.75127140240712e-05 TCAF1/DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/CDH1/KCNN4/STOM/ISL1/EZR/SOX4/GLI3/GLUL/OAZ1/NMT1/B3GAT3/MDM2/MPC2/EXOC1/HUWE1/CDC42/HRAS/VAMP2/UBE2D3/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 33 GO:0043434 response to peptide hormone 39/725 414/18722 3.05830396622889e-07 7.75127140240712e-05 ATP2B1/FBN1/CAV1/IGF2/KANK1/DAG1/JUND/CYP11A1/PKM/TGFBR3/PRKDC/GJA1/ANXA1/BTG2/PARP1/CSH1/NFE2L2/LEPROTL1/LRP5/LPIN2/PTPRA/BMP7/SOCS1/ESRRA/ROCK1/GHR/SLC9A1/MDM2/IQGAP1/ZNF106/CAT/HADHA/SRSF6/SLC2A8/PIP4K2A/VAMP2/GDF15/CFLAR/CYBA 39 GO:0050714 positive regulation of protein secretion 20/725 137/18722 3.24865975490248e-07 7.84164585600033e-05 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ISL1/EZR/SOX4/GLUL/MPC2/EXOC1/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 20 GO:0050673 epithelial cell proliferation 40/725 437/18722 4.56737220931768e-07 0.000105236407859233 NRP2/CAV1/IGF2/LGR5/LGR4/TGFBR3/LAMC1/PRKDC/LAMB1/MAGED1/EGFR/GJA1/NR2F2/ISL1/PGF/PDCD6/GRN/NF1/GLUL/GPC3/CEBPB/APELA/DLG1/MTSS1/SERPINF1/SRSF6/CDC42/PURA/HRAS/HES1/KDM5B/SERPINB1/RTN4/CDKN1C/CFLAR/HMGB1/ZNF703/FLT1/B2M/CYBA 40 GO:1901654 response to ketone 24/725 194/18722 5.24128376943438e-07 0.000115513336640273 ATP2B1/CAV1/FOS/AKR1B1/TGFBR3/DUSP1/EGFR/FOSB/CALM1/PARP1/TXNIP/NASP/CSNK2B/LARP1/CLDN4/NR3C1/HSD3B1/SERPINF1/RPL27/CDKN1A/NCOA2/CFLAR/FDX1/CYBA 24 GO:0007044 cell-substrate junction assembly 16/725 95/18722 6.89119675580423e-07 0.000141002878647505 ITGB4/LRP1/LAMC1/ITGA6/DST/MACF1/RHOA/PTPRA/ACTG1/ROCK1/BCL2/PLEC/SLC9A1/IQGAP1/PHLDB2/RAC1 16 GO:0031589 cell-substrate adhesion 35/725 363/18722 7.20209582542452e-07 0.000141002878647505 ITGB1/FBLN1/ITGB4/LRP1/UTRN/KANK1/CD63/DAG1/ITGAV/CCDC80/LAMC1/ITGA6/LAMB1/LAMA5/BCAM/MACF1/TRIOBP/RHOA/PTPRA/NF1/JAM3/P4HB/ACTG1/ROCK1/BCL2/SLC9A1/IQGAP1/PHLDB2/CDC42/RASA1/TACSTD2/RAB1A/SERPINE1/RAC1/PIK3CB 35 GO:0001890 placenta development 20/725 144/18722 7.35241255467957e-07 0.000141002878647505 KRT19/KRT8/SPINT1/IGF2/MAP3K4/GJA1/RPS6/NR2F2/RBPJ/PHLDA2/BMP7/CTSV/BPTF/ASH1L/TFEB/CEBPB/APELA/BIRC6/HES1/SETD2 20 GO:0032970 regulation of actin filament-based process 37/725 396/18722 7.51051040339836e-07 0.000141002878647505 IQGAP2/AKAP9/CAV1/LRP1/KANK1/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/JAM3/PDE4B/DSG2/ACTG1/ROCK1/GJA5/WASF2/SLC9A1/DLG1/RHOB/IQGAP1/DSC2/ARPC3/PHLDB2/PFN1/MTSS1/CDC42/HRAS/RHOBTB3/RASA1/TACSTD2/SRI/PHPT1/RAC1/ARF1/CAPZB 37 GO:0071559 response to transforming growth factor beta 28/725 256/18722 7.85419186014266e-07 0.000142188923353797 PEG10/FBN1/FBN2/CAV1/HTRA4/FOS/JUN/GLG1/TGFBR3/PARP1/ZFHX3/HSPA5/ZNF451/LTBP1/NREP/ROCK1/LATS2/COL4A2/FUT8/HSPA1A/NR3C1/USP9X/CDKN1C/GDF15/CFLAR/ZNF703/ENG/SDCBP 28 GO:0001656 metanephros development 15/725 85/18722 8.25287301213036e-07 0.000144254528615479 FBN1/DLG5/BASP1/LGR4/AKR1B1/GLI3/NF1/BMP7/GPC3/FRAS1/IRX2/RDH10/BCL2/NIPBL/HES1 15 GO:0097193 intrinsic apoptotic signaling pathway 30/725 288/18722 9.04422140255195e-07 0.000152817194298453 TPT1/CAV1/MIF/PMAIP1/S100A9/PRKDC/DDX5/PARP1/NFE2L2/PTTG1IP/RPL26/ENO1/HSPB1/P4HB/BCL2/CEBPB/HERPUD1/ARL6IP5/HSPA1A/MDM2/HINT1/PPP1R15A/ERO1A/HRAS/GRINA/CDKN1A/ERP29/DDIT3/EIF5A/PPIA 30 GO:0051384 response to glucocorticoid 20/725 148/18722 1.14384324452379e-06 0.000187036819564228 ATP2B1/FOS/AGL/HSPD1/DUSP1/EGFR/FOSB/ANXA1/CALM1/ISL1/RHOA/CTSV/BCL2/GHR/NR3C1/HSD3B1/SERPINF1/CDKN1A/CFLAR/HMGB1 20 GO:2001242 regulation of intrinsic apoptotic signaling pathway 21/725 164/18722 1.52019696496248e-06 0.000231275622886151 TPT1/CAV1/MIF/PMAIP1/S100A9/PARP1/NFE2L2/PTTG1IP/RPL26/ENO1/HSPB1/P4HB/BCL2/HERPUD1/HSPA1A/MDM2/GRINA/ERP29/DDIT3/EIF5A/PPIA 21 GO:0048024 regulation of mRNA splicing, via spliceosome 16/725 101/18722 1.60878072231823e-06 0.000231275622886151 PRDX6/SON/RBM39/HSPA8/SF1/DDX5/SAP18/NPM1/RBM25/SRSF9/TRA2B/SRSF7/HNRNPA1/DDX17/QKI/SRSF6 16 GO:0150115 cell-substrate junction organization 16/725 101/18722 1.60878072231823e-06 0.000231275622886151 ITGB4/LRP1/LAMC1/ITGA6/DST/MACF1/RHOA/PTPRA/ACTG1/ROCK1/BCL2/PLEC/SLC9A1/IQGAP1/PHLDB2/RAC1 16 GO:0010810 regulation of cell-substrate adhesion 25/725 221/18722 1.64251448304343e-06 0.000231275622886151 FBLN1/LRP1/UTRN/KANK1/DAG1/CCDC80/ITGA6/MACF1/TRIOBP/RHOA/PTPRA/NF1/P4HB/ACTG1/ROCK1/BCL2/SLC9A1/IQGAP1/PHLDB2/CDC42/RASA1/TACSTD2/SERPINE1/RAC1/PIK3CB 25 GO:0090132 epithelium migration 34/725 360/18722 1.65532232427638e-06 0.000231275622886151 NRP2/ITGB1/KANK1/PLPP3/EPHB4/ANXA1/MET/NR2F2/MACF1/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/S100P/CSNK2B/ROCK1/LGMN/PKN2/APELA/RHOB/PFN1/SERPINF1/SASH1/AMOT/TACSTD2/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 34 GO:0048762 mesenchymal cell differentiation 26/725 236/18722 1.68814323274563e-06 0.000231275622886151 NRP2/DLG5/SEMA6D/DAG1/SEMA6A/TGFBR3/DDX5/LAMA5/TBX3/ISL1/PDCD4/RBPJ/PDCD6/BMP7/ROCK1/RDH10/BCL2/DDX17/PHLDB2/HNRNPAB/HES1/SEMA4C/RTN4/ZNF703/ENG/SDCBP 26 GO:0070482 response to oxygen levels 33/725 347/18722 2.01975030048466e-06 0.000269424059819914 LDHA/MALAT1/CAV1/SOD3/PMAIP1/TGFBR3/HSPD1/PGF/RBPJ/NFE2L2/HSP90B1/DNMT3A/RHOA/ENO1/NF1/SLC6A4/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/CAT/CPEB4/ERO1A/SLC2A8/CDKN1A/CFLAR/CHCHD2/BACH1/CYBA/ATP6V1G1 33 GO:0050678 regulation of epithelial cell proliferation 35/725 381/18722 2.19953300932141e-06 0.000285566804249512 NRP2/CAV1/IGF2/TGFBR3/LAMC1/PRKDC/LAMB1/MAGED1/EGFR/GJA1/NR2F2/ISL1/PGF/PDCD6/GRN/NF1/GLUL/GPC3/APELA/DLG1/MTSS1/SERPINF1/SRSF6/CDC42/HRAS/HES1/KDM5B/RTN4/CDKN1C/CFLAR/HMGB1/ZNF703/FLT1/B2M/CYBA 35 GO:0090130 tissue migration 34/725 365/18722 2.25343700334987e-06 0.000285566804249512 NRP2/ITGB1/KANK1/PLPP3/EPHB4/ANXA1/MET/NR2F2/MACF1/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/S100P/CSNK2B/ROCK1/LGMN/PKN2/APELA/RHOB/PFN1/SERPINF1/SASH1/AMOT/TACSTD2/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 34 GO:0001701 in utero embryonic development 34/725 367/18722 2.54433567697097e-06 0.000311411690939898 KRT19/KRT8/ITGB1/SPINT1/IGF2/TBX3/RPL13/NR2F2/RBPJ/PHLDA2/BTF3/NASP/GLI3/N4BP2L2/BMP7/BPTF/MIB1/NMT1/TFEB/RDH10/CEBPB/FUT8/EIF2S2/BIRC6/RTF1/HOPX/LY6E/HES1/AMOT/SETD2/RTN4/MBD3/UBE2A/YBX1 34 GO:0060993 kidney morphogenesis 15/725 93/18722 2.68960017365276e-06 0.000311411690939898 BASP1/LGR4/MAGED1/LAMA5/SOX4/GLI3/PBX1/BMP7/GPC3/FRAS1/IRX2/BCL2/DLG1/HES1/TACSTD2 15 GO:0007179 transforming growth factor beta receptor signaling pathway 23/725 198/18722 2.70311982666315e-06 0.000311411690939898 PEG10/FBN1/FBN2/CAV1/HTRA4/FOS/JUN/GLG1/TGFBR3/PARP1/HSPA5/ZNF451/LTBP1/NREP/LATS2/FUT8/HSPA1A/USP9X/CDKN1C/GDF15/ZNF703/ENG/SDCBP 23 GO:0031099 regeneration 23/725 198/18722 2.70311982666315e-06 0.000311411690939898 LRP1/RPL19/DAG1/TGFBR3/EGFR/ANXA1/RPS16/ISL1/PGF/GRN/GLI3/JAM3/CSNK2B/MTR/NREP/BCL2/CEBPB/PTPN12/PTPRF/HOPX/UPF2/CDKN1A/CFLAR 23 GO:0090287 regulation of cellular response to growth factor stimulus 30/725 304/18722 2.77622920307141e-06 0.000312726796230422 PEG10/FBN1/FBN2/CAV1/HTRA4/CD63/LRP2/SEMA6A/GLG1/TGFBR3/RBPJ/FSTL3/PDCD6/CRIM1/GPC3/HSPA5/ZNF451/LTBP1/NREP/LATS2/HSPA1A/HES1/NUMA1/CDKN1C/UBE2D3/CFLAR/ZNF703/ENG/PIK3CB/SDCBP 30 GO:0001892 embryonic placenta development 14/725 82/18722 2.88013424579166e-06 0.000317378271563433 KRT19/KRT8/SPINT1/IGF2/NR2F2/RBPJ/PHLDA2/BMP7/BPTF/TFEB/CEBPB/BIRC6/HES1/SETD2 14 GO:0060537 muscle tissue development 36/725 403/18722 3.01013632412809e-06 0.000322846545858605 CAV1/ITGB1/IGF2/FOS/LRP2/TGFBR3/GJA1/DDX5/TBX3/NEURL1/NR2F2/BTG2/ISL1/RBPJ/RHOA/NF1/BMP7/HMG20B/MYL6/HOMER1/DSG2/GJA5/BCL2/PLEC/SLC9A1/DLG1/GPCPD1/FLNB/DDX17/CDC42/HOPX/LY6E/CFLAR/CENPF/ENG/ATF3 36 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 18/725 131/18722 3.05713833127107e-06 0.000322846545858605 PEG10/FBN1/FBN2/CAV1/HTRA4/GLG1/TGFBR3/HSPA5/ZNF451/LTBP1/NREP/LATS2/HSPA1A/CDKN1C/CFLAR/ZNF703/ENG/SDCBP 18 GO:0036293 response to decreased oxygen levels 31/725 322/18722 3.18734672701628e-06 0.000329727766515215 LDHA/MALAT1/CAV1/SOD3/PMAIP1/TGFBR3/HSPD1/PGF/RBPJ/NFE2L2/HSP90B1/DNMT3A/RHOA/ENO1/NF1/SLC6A4/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/CAT/CPEB4/ERO1A/SLC2A8/CFLAR/CHCHD2/BACH1/CYBA 31 GO:0001666 response to hypoxia 30/725 307/18722 3.3901195395388e-06 0.000338090398383044 LDHA/MALAT1/CAV1/SOD3/PMAIP1/TGFBR3/HSPD1/PGF/RBPJ/NFE2L2/HSP90B1/DNMT3A/RHOA/ENO1/NF1/SLC6A4/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/CAT/ERO1A/SLC2A8/CFLAR/CHCHD2/BACH1/CYBA 30 GO:0042273 ribosomal large subunit biogenesis 13/725 72/18722 3.4015802559746e-06 0.000338090398383044 RPLP0/RPL24/RPL23A/RPL14/RPL6/RPL10/RPL26/NPM1/RPL10A/RPL3/RPL7A/RPL7/SNU13 13 GO:0010631 epithelial cell migration 33/725 357/18722 3.74186249801554e-06 0.000364759634662322 NRP2/ITGB1/KANK1/PLPP3/EPHB4/ANXA1/MET/NR2F2/MACF1/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/S100P/CSNK2B/ROCK1/LGMN/PKN2/RHOB/PFN1/SERPINF1/SASH1/AMOT/TACSTD2/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 33 GO:1901653 cellular response to peptide 33/725 359/18722 4.21835996711807e-06 0.000403450314590972 ATP2B1/FBN1/CAV1/IGF2/LRP1/KANK1/APP/CYP11A1/PKM/AKR1B1/PRKDC/GJA1/PARP1/CSH1/NFE2L2/LEPROTL1/LPIN2/PTPRA/SOCS1/ESRRA/ROCK1/LGMN/GHR/SLC9A1/MDM2/ZNF106/SLC2A8/PIP4K2A/VAMP2/GDF15/CFLAR/RIPK2/CYBA 33 GO:0071560 cellular response to transforming growth factor beta stimulus 26/725 250/18722 4.92272835591814e-06 0.000462098334002761 PEG10/FBN1/FBN2/CAV1/HTRA4/FOS/JUN/GLG1/TGFBR3/PARP1/HSPA5/ZNF451/LTBP1/NREP/LATS2/COL4A2/FUT8/HSPA1A/NR3C1/USP9X/CDKN1C/GDF15/CFLAR/ZNF703/ENG/SDCBP 26 GO:0048638 regulation of developmental growth 31/725 330/18722 5.28288115581039e-06 0.000485252938867917 IGF2/LRP1/BASP1/SEMA6D/APP/SEMA6A/TGFBR3/PRKDC/ADRB1/GJA1/MACF1/DUSP6/RBPJ/GOLGA4/EZR/SLC6A4/DUSP9/SPAG9/LATS2/BCL2/AFG3L2/LGMN/GHR/NIPBL/HOPX/CDKN1A/SEMA4C/RAB11A/RTN4/GDF15/SERP1 31 GO:0045995 regulation of embryonic development 12/725 64/18722 5.3608531419616e-06 0.000485252938867917 DAG1/LAMA5/PHLDA2/NFE2L2/DHX36/CFL1/NIPBL/PHLDB2/TDG/HES1/AMOT/CCSAP 12 GO:0061333 renal tubule morphogenesis 13/725 75/18722 5.45787717228641e-06 0.000485368059409119 LGR5/LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/MTSS1/HES1/TACSTD2 13 GO:0014706 striated muscle tissue development 34/725 384/18722 6.83751362248222e-06 0.000581465458601294 CAV1/ITGB1/IGF2/FOS/LRP2/TGFBR3/GJA1/DDX5/TBX3/NEURL1/NR2F2/BTG2/ISL1/RBPJ/RHOA/BMP7/HMG20B/MYL6/HOMER1/DSG2/GJA5/BCL2/PLEC/SLC9A1/GPCPD1/FLNB/DDX17/CDC42/HOPX/LY6E/CFLAR/CENPF/ENG/ATF3 34 GO:0051385 response to mineralocorticoid 9/725 36/18722 6.85053954469461e-06 0.000581465458601294 ATP2B1/FOS/FOSB/CALM1/PARP1/HSD3B1/RPL27/CDKN1A/CYBA 9 GO:0060538 skeletal muscle organ development 20/725 166/18722 6.88260554667146e-06 0.000581465458601294 CAV1/IGF2/BASP1/FOS/DAG1/DDX5/NEURL1/NR2F2/BTG2/RHOA/HMG20B/MYL6/HOMER1/BCL2/PLEC/GPCPD1/FLNB/DDX17/CFLAR/ATF3 20 GO:0042326 negative regulation of phosphorylation 34/725 385/18722 7.23002176299614e-06 0.000600802956010286 DYNLL1/CAV1/FBLN1/LRP1/PLPP3/IGFBP3/PRKDC/DUSP1/CTDSPL/GADD45B/CALM1/NR2F2/DUSP6/PDCD4/LRP5/NF1/NPM1/HSPB1/BMP7/SOCS1/SPAG9/PKIB/ROCK1/LATS2/GNAQ/PLEC/INHA/PIP4K2A/CDKN1A/CDKN1C/ENG/PIK3CB/PPIA/CBLB 34 GO:0001763 morphogenesis of a branching structure 22/725 196/18722 7.75400741011945e-06 0.000633952638095089 SPINT1/DLG5/LGR4/DAG1/MAGED1/LAMA5/TBX3/MET/GLI3/PBX1/LRP5/BMP7/GPC3/RDH10/BCL2/DLG1/RERE/KDM5B/SETD2/TACSTD2/RTN4/ENG 22 GO:0071826 ribonucleoprotein complex subunit organization 24/725 227/18722 8.54225736289677e-06 0.000687312739246408 RPLP0/RPL24/RPL23A/EIF4H/KIF5B/PRKDC/SF1/RPL6/SCAF11/RPL10/RPS19/RPL13A/SRSF9/RPS5/DICER1/RPL3/EIF2S2/SRSF6/AGO2/EIF3H/SNU13/EIF3I/SNRPD2/RPSA 24 GO:0032355 response to estradiol 18/725 141/18722 8.76774967802009e-06 0.000694433173716935 DUSP1/EGFR/GJA1/ANXA1/NR2F2/TXNIP/DNMT3A/SLC6A4/BMP7/ESRRA/NCOA3/GPX4/CAT/FAM210B/CFLAR/ZNF703/MBD3/CYP19A1 18 GO:0001952 regulation of cell-matrix adhesion 17/725 128/18722 9.0968521823162e-06 0.000698665813820619 LRP1/UTRN/DAG1/MACF1/RHOA/PTPRA/NF1/ACTG1/ROCK1/BCL2/SLC9A1/IQGAP1/PHLDB2/RASA1/SERPINE1/RAC1/PIK3CB 17 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 17/725 128/18722 9.0968521823162e-06 0.000698665813820619 PEG10/FBN1/FBN2/CAV1/HTRA4/GLG1/TGFBR3/HSPA5/ZNF451/LTBP1/NREP/LATS2/HSPA1A/CDKN1C/ZNF703/ENG/SDCBP 17 GO:0045936 negative regulation of phosphate metabolic process 37/725 441/18722 9.28091044515532e-06 0.000702163209649139 DYNLL1/CAV1/FBLN1/LRP1/PLPP3/IGFBP3/PRKDC/DUSP1/CTDSPL/GADD45B/CALM1/NR2F2/DUSP6/PDCD4/PARP1/LRP5/NF1/NPM1/HSPB1/BMP7/SOCS1/SPAG9/PKIB/ROCK1/LATS2/GNAQ/BOD1L1/PLEC/PPP1R15A/INHA/PIP4K2A/CDKN1A/CDKN1C/ENG/PIK3CB/PPIA/CBLB 37 GO:0060485 mesenchyme development 28/725 291/18722 9.56030742565714e-06 0.000712664681480236 NRP2/DLG5/BASP1/SEMA6D/DAG1/SEMA6A/TGFBR3/DDX5/LAMA5/TBX3/ISL1/PDCD4/RBPJ/PDCD6/BMP7/ROCK1/RDH10/BCL2/MDM2/DDX17/PHLDB2/HNRNPAB/HES1/SEMA4C/RTN4/ZNF703/ENG/SDCBP 28 GO:0010563 negative regulation of phosphorus metabolic process 37/725 442/18722 9.76414193046236e-06 0.000717310658630634 DYNLL1/CAV1/FBLN1/LRP1/PLPP3/IGFBP3/PRKDC/DUSP1/CTDSPL/GADD45B/CALM1/NR2F2/DUSP6/PDCD4/PARP1/LRP5/NF1/NPM1/HSPB1/BMP7/SOCS1/SPAG9/PKIB/ROCK1/LATS2/GNAQ/BOD1L1/PLEC/PPP1R15A/INHA/PIP4K2A/CDKN1A/CDKN1C/ENG/PIK3CB/PPIA/CBLB 37 GO:0001657 ureteric bud development 14/725 91/18722 1.01441580762605e-05 0.000725604505362355 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/BCL2/DLG1/CAT/HES1/TACSTD2/ARG2 14 GO:0007548 sex differentiation 27/725 276/18722 1.0163330021844e-05 0.000725604505362355 BASP1/ADGRG1/LGR4/LRP2/DHCR24/SF1/TBX3/NR2F2/FSTL3/NASP/IDH1/PBX1/CTSV/HSPA5/ATRX/ADAMTS1/RDH10/BCL2/CEBPB/ARID5B/EIF2S2/NIPBL/KDM5A/INHA/RHOBTB3/ZFX/CYP19A1 27 GO:0022604 regulation of cell morphogenesis 29/725 309/18722 1.07565975042527e-05 0.000757294343736904 ALDOA/FBLN1/CUX1/MYH10/KANK1/DAG1/PRKDC/ARHGAP18/ANXA1/MACF1/TRIOBP/EZR/RHOA/P4HB/SPAG9/DHX36/CLDN4/CFL1/DLG1/RHOB/MYL12B/BRWD1/CDC42/RHOBTB3/EPB41L3/RASA1/TACSTD2/RAC1/CAPZB 29 GO:0072163 mesonephric epithelium development 14/725 92/18722 1.15452235531825e-05 0.00078651522220701 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/BCL2/DLG1/CAT/HES1/TACSTD2/ARG2 14 GO:0072164 mesonephric tubule development 14/725 92/18722 1.15452235531825e-05 0.00078651522220701 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/BCL2/DLG1/CAT/HES1/TACSTD2/ARG2 14 GO:0022613 ribonucleoprotein complex biogenesis 38/725 463/18722 1.16371358582611e-05 0.00078651522220701 RPLP0/RPL24/RPL23A/RPS21/EIF4H/RPL14/PRKDC/SF1/RPS6/RPL6/RPS16/SCAF11/RPS8/RPS25/RPL10/RPL26/RPS19/GLUL/NPM1/RPL13A/SRSF9/RPS5/RPL10A/DICER1/RPL3/EIF2S2/DDX17/SRSF6/RPL7A/RPL7/RPL27/AGO2/EIF3H/SNU13/EIF3I/SNRPD2/NOP10/RPSA 38 GO:0022618 ribonucleoprotein complex assembly 23/725 220/18722 1.57213266847191e-05 0.00104857111795843 RPLP0/RPL24/RPL23A/EIF4H/PRKDC/SF1/RPL6/SCAF11/RPL10/RPS19/RPL13A/SRSF9/RPS5/DICER1/RPL3/EIF2S2/SRSF6/AGO2/EIF3H/SNU13/EIF3I/SNRPD2/RPSA 23 GO:0050708 regulation of protein secretion 26/725 268/18722 1.70891723123154e-05 0.00112012163356739 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ANXA1/ISL1/EZR/SOX4/LRP5/GLUL/RAB11FIP1/SYT7/HMGN3/MPC2/EXOC1/ERP29/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 26 GO:0140694 non-membrane-bounded organelle assembly 32/725 367/18722 1.7268384950195e-05 0.00112012163356739 KRT19/KRT8/ITGB1/RPLP0/RPL24/RPL23A/CEP152/PRKDC/PRRC2C/RPL6/EZR/RPL10/RPS19/RHOA/NPM1/DYNC1H1/RPS5/ACTG1/PLEC/HSPA1A/GPSM2/RPL3/CDS1/KPNB1/STAG1/NEK6/NUMA1/RAB11A/CFLAR/CCSAP/CENPF/RPSA 32 GO:0019058 viral life cycle 29/725 317/18722 1.74570150033189e-05 0.00112012163356739 CAV1/ITGB1/CD46/TFRC/DAG1/ITGAV/HACD3/HSPA8/DDB1/EGFR/DDX5/STOM/MPHOSPH8/CTSL/P4HB/BCL2/LARP1/PKN2/SLC52A1/HSPA1A/DEK/CD55/CDC42/UVRAG/LY6E/RAB1A/PPIA/ARL8B/RPSA 29 GO:0071453 cellular response to oxygen levels 20/725 177/18722 1.80081484160075e-05 0.00114104130400928 MALAT1/CAV1/PMAIP1/RBPJ/NFE2L2/DNMT3A/ENO1/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/CPEB4/ERO1A/CFLAR/CHCHD2/BACH1/ATP6V1G1 20 GO:0030953 astral microtubule organization 5/725 10/18722 1.84051496255708e-05 0.00115179880804961 EZR/DLG1/KPNB1/NUMA1/RAB11A 5 GO:1903036 positive regulation of response to wounding 12/725 72/18722 1.88914089164893e-05 0.00116101475704951 ITGB1/LRP1/KANK1/PLPP3/ANXA1/NFE2L2/GRN/ACTG1/CLDN4/HRAS/HMGB1/SERPINE1 12 GO:0001823 mesonephros development 14/725 96/18722 1.90105000661096e-05 0.00116101475704951 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/BCL2/DLG1/CAT/HES1/TACSTD2/ARG2 14 GO:0042255 ribosome assembly 11/725 61/18722 1.94299016094205e-05 0.00117250203878753 RPLP0/RPL24/RPL23A/PRKDC/RPL6/RPL10/RPS19/NPM1/RPS5/RPL3/RPSA 11 GO:0072073 kidney epithelium development 17/725 136/18722 2.04660134503105e-05 0.00122049673152499 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/IRX2/BCL2/DLG1/IQGAP1/CAT/MTSS1/HES1/TACSTD2/ARG2 17 GO:0061008 hepaticobiliary system development 18/725 150/18722 2.07165996259146e-05 0.00122107492446234 RPL19/KRT18/TGFBR3/EGFR/ANXA1/MET/RPS16/GLI3/NF1/COBL/CSNK2B/CEBPB/ARID5B/NIPBL/HRAS/UPF2/HES1/CFLAR 18 GO:0014812 muscle cell migration 15/725 110/18722 2.20130822226999e-05 0.00126375561168076 LRP1/S100A11/SEMA6D/IGFBP3/ANXA1/GNA12/NFE2L2/RHOA/ADAMTS1/ROCK1/BCL2/MDM2/IQGAP1/NET1/SERPINE1 15 GO:0034976 response to endoplasmic reticulum stress 25/725 256/18722 2.20881821403463e-05 0.00126375561168076 CAV1/JUN/PMAIP1/NFE2L2/HSP90B1/HSPA5/P4HB/UBXN4/BCL2/CEBPB/HERPUD1/HSPA1A/UFL1/CCDC47/PPP1R15A/UBA5/ERO1A/DNAJB14/GRINA/PDIA4/ERP29/SEC61B/DDIT3/SERP1/ATF3 25 GO:0006986 response to unfolded protein 17/725 137/18722 2.25395579626847e-05 0.00126375561168076 HSPD1/HSPA8/NFE2L2/HSPB1/HSPA5/UBXN4/HERPUD1/HSPB8/HSPA1A/UFL1/PPP1R15A/ERO1A/DNAJB4/SERPINH1/DDIT3/SERP1/ATF3 17 GO:0050684 regulation of mRNA processing 17/725 137/18722 2.25395579626847e-05 0.00126375561168076 PRDX6/SON/RBM39/HSPA8/SF1/DDX5/SAP18/NPM1/RBM25/DHX36/SRSF9/TRA2B/SRSF7/HNRNPA1/DDX17/QKI/SRSF6 17 GO:0048754 branching morphogenesis of an epithelial tube 18/725 151/18722 2.26872678364469e-05 0.00126375561168076 DLG5/LGR4/DAG1/MAGED1/LAMA5/TBX3/MET/GLI3/PBX1/LRP5/BMP7/GPC3/RDH10/BCL2/DLG1/KDM5B/TACSTD2/ENG 18 GO:0010038 response to metal ion 32/725 373/18722 2.38387730016021e-05 0.00129411452504322 CAV1/FOS/APP/FUS/JUN/SOD3/JUND/DUSP1/EGFR/CDH1/FOSB/CALM1/PARP1/FSTL3/TXNIP/NFE2L2/PDCD6/DNMT3A/HSPA5/HOMER1/BCL2/LGMN/MDM2/IQGAP1/CAT/SYT7/SERPINF1/CYB5A/TFAP2A/HSD17B1/UBE2D3/B2M 32 GO:2001233 regulation of apoptotic signaling pathway 31/725 356/18722 2.38945805827187e-05 0.00129411452504322 TPT1/CAV1/MIF/ITGAV/PMAIP1/S100A9/CTSC/ITGA6/MAGED1/PARP1/NFE2L2/PTTG1IP/RPL26/ENO1/HSPB1/P4HB/BCL2/HERPUD1/HSPA1A/MDM2/BIRC6/GRINA/ERP29/CFLAR/DDIT3/EIF5A/SERPINE1/TMBIM1/ATF3/TIMP3/PPIA 31 GO:0071241 cellular response to inorganic substance 23/725 226/18722 2.42533002858349e-05 0.00129411452504322 FOS/APP/FUS/JUN/JUND/EGFR/CDH1/FOSB/PARP1/FSTL3/NFE2L2/HSPA5/ATRX/MTR/LGMN/IQGAP1/SYT7/SERPINF1/TFAP2A/HSD17B1/UBE2D3/CFLAR/B2M 23 GO:0001503 ossification 34/725 408/18722 2.44266040707366e-05 0.00129411452504322 SLC26A2/ATP2B1/FBN2/RRBP1/IGF2/LGR4/SMOC1/JUND/EGFR/DDX5/RBPJ/FSTL3/CRIM1/GLI3/IL6ST/PBX1/RHOA/LRP5/NF1/BMP7/GPC3/DHX36/SUCO/ESRRA/BCL2/CLTC/CEBPB/UFL1/CCDC47/CAT/NIPBL/TFAP2A/TPM4/CLIC1 34 GO:0052547 regulation of peptidase activity 37/725 461/18722 2.46581990261422e-05 0.00129411452504322 GAPDH/SERPINB9/ITIH5/CAV1/FBLN1/SPINT1/APLP2/LRP1/APP/PMAIP1/S100A9/DHCR24/HSPD1/TFPI2/PDCD6/GRN/CRIM1/RHOA/GPC3/ROCK1/LGMN/CLDN4/HERPUD1/ARL6IP5/MDM2/BIRC6/ASPH/SERPINF1/SERPINH1/SERPINB1/CFLAR/RIPK2/HMGB1/SERPINB2/SERPINE1/TIMP3/TIMP2 37 GO:0071375 cellular response to peptide hormone stimulus 27/725 290/18722 2.47640775161161e-05 0.00129411452504322 ATP2B1/FBN1/CAV1/IGF2/KANK1/CYP11A1/PKM/PRKDC/PARP1/CSH1/NFE2L2/LEPROTL1/LPIN2/PTPRA/SOCS1/ESRRA/ROCK1/GHR/SLC9A1/MDM2/ZNF106/SLC2A8/PIP4K2A/VAMP2/GDF15/CFLAR/CYBA 27 GO:1903034 regulation of response to wounding 19/725 167/18722 2.63163493355484e-05 0.0013611997426724 CAV1/ITGB1/LRP1/KANK1/PLPP3/GJA1/ANXA1/NFE2L2/GRN/ACTG1/CLDN4/PHLDB2/C1QTNF1/PTPRF/SRSF6/HRAS/HMGB1/SERPINB2/SERPINE1 19 GO:0001933 negative regulation of protein phosphorylation 30/725 342/18722 2.80572274145188e-05 0.00143658672489087 CAV1/FBLN1/LRP1/PLPP3/IGFBP3/PRKDC/DUSP1/CTDSPL/GADD45B/CALM1/NR2F2/DUSP6/PDCD4/LRP5/NF1/NPM1/HSPB1/BMP7/SOCS1/SPAG9/PKIB/LATS2/GNAQ/PLEC/CDKN1A/CDKN1C/ENG/PIK3CB/PPIA/CBLB 30 GO:0007519 skeletal muscle tissue development 18/725 155/18722 3.23478035331135e-05 0.00162973065904137 CAV1/IGF2/FOS/DDX5/NEURL1/NR2F2/BTG2/RHOA/HMG20B/MYL6/HOMER1/BCL2/PLEC/GPCPD1/FLNB/DDX17/CFLAR/ATF3 18 GO:0009636 response to toxic substance 25/725 262/18722 3.26029220128833e-05 0.00162973065904137 GPX3/PRDX6/FOS/SOD3/S100A9/CDH1/DHRS2/UBA52/NFE2L2/ABCB1/DNMT3A/PPP1R9A/SLC6A4/BMP7/SRSF9/BCL2/GPX4/MDM2/CAT/ADH5/CDKN1A/KDM5B/TXNRD1/GLRX/GSTO1 25 GO:0033119 negative regulation of RNA splicing 7/725 25/18722 3.31072622055854e-05 0.00162973065904137 RPS13/SAP18/NPM1/RPS26/SRSF9/SRSF7/SRSF6 7 GO:0072028 nephron morphogenesis 12/725 76/18722 3.31154582523696e-05 0.00162973065904137 LGR4/MAGED1/LAMA5/GLI3/PBX1/BMP7/GPC3/IRX2/BCL2/DLG1/HES1/TACSTD2 12 GO:0072006 nephron development 17/725 142/18722 3.59740493906648e-05 0.00174288449500987 BASP1/LGR4/MAGED1/LAMA5/ENPEP/GLI3/PBX1/BMP7/GPC3/IRX2/BCL2/DLG1/IQGAP1/MTSS1/HES1/TACSTD2/CFLAR 17 GO:0086004 regulation of cardiac muscle cell contraction 8/725 34/18722 3.61023618023349e-05 0.00174288449500987 AKAP9/CAV1/PDE4B/DSG2/GJA5/DLG1/DSC2/SRI 8 GO:0001837 epithelial to mesenchymal transition 18/725 157/18722 3.84302879196068e-05 0.00183776537230648 DLG5/DAG1/TGFBR3/DDX5/TBX3/ISL1/PDCD4/RBPJ/PDCD6/BMP7/ROCK1/DDX17/PHLDB2/HNRNPAB/RTN4/ZNF703/ENG/SDCBP 18 GO:0007160 cell-matrix adhesion 23/725 233/18722 3.93236584377449e-05 0.00186291237963485 ITGB1/ITGB4/LRP1/UTRN/CD63/DAG1/ITGAV/BCAM/MACF1/RHOA/PTPRA/NF1/JAM3/ACTG1/ROCK1/BCL2/SLC9A1/IQGAP1/PHLDB2/RASA1/SERPINE1/RAC1/PIK3CB 23 GO:1903532 positive regulation of secretion by cell 26/725 282/18722 4.11135166150042e-05 0.00192967051593941 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ISL1/EZR/SOX4/SLC6A4/GLUL/SYT7/C1QTNF1/MPC2/EXOC1/INHA/SRI/SERP1/PHPT1/RAC1/CYP19A1/ARF1/PPIA/SDCBP 26 GO:0003279 cardiac septum development 14/725 103/18722 4.25927565725142e-05 0.00198075856023921 ADAMTS6/NRP2/LRP2/TGFBR3/TBX3/ISL1/RBPJ/SOX4/BMP7/GJA5/MDM2/TRIP11/HES1/ENG 14 GO:0032024 positive regulation of insulin secretion 12/725 78/18722 4.31987792502245e-05 0.00199067829108535 DYNLL1/LRP1/KIF5B/GJA1/ISL1/SOX4/GLUL/MPC2/SRI/SERP1/PHPT1/RAC1 12 GO:0009314 response to radiation 36/725 456/18722 4.46947100862501e-05 0.00203890320452742 ITGB1/FOS/MAP3K4/APP/JUN/JUND/PRKDC/DUSP1/DDB1/EGFR/ANXA1/PARP1/RPL26/DNMT3A/LRP5/OPN3/NF1/NPM1/HSPA5/NMT1/DHX36/GNAQ/BCL2/MDM2/RHOB/CAT/DYNLRB1/CDS1/NIPBL/NET1/ADIRF/HRAS/CDKN1A/RDH13/UBE2A/CYBA 36 GO:0071692 protein localization to extracellular region 31/725 368/18722 4.50497452963249e-05 0.00203890320452742 FBN1/DYNLL1/FBN2/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ANXA1/ISL1/EZR/SOX4/LRP5/GLUL/LTBP1/RAB11FIP1/CAMK2G/SYT7/HMGN3/MPC2/EXOC1/PDIA4/ERP29/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 31 GO:0035966 response to topologically incorrect protein 18/725 159/18722 4.55079443799025e-05 0.00204141389435156 HSPD1/HSPA8/NFE2L2/HSPB1/HSPA5/UBXN4/HERPUD1/HSPB8/HSPA1A/UFL1/PPP1R15A/ERO1A/DNAJB14/DNAJB4/SERPINH1/DDIT3/SERP1/ATF3 18 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 16/725 131/18722 4.73907943965977e-05 0.00210722751575749 PEG10/FBN1/FBN2/CAV1/LRP1/HTRA4/LRP2/GLG1/TGFBR3/FSTL3/CRIM1/HSPA5/ZNF451/LTBP1/HSPA1A/UBE2D3 16 GO:0031122 cytoplasmic microtubule organization 10/725 56/18722 5.05265961111946e-05 0.00221351612093547 CLIP1/DST/EZR/RHOA/DYNC1H1/HOOK3/DLG1/KPNB1/NUMA1/RAB11A 10 GO:0008406 gonad development 22/725 221/18722 5.06545413352761e-05 0.00221351612093547 BASP1/ADGRG1/LRP2/SF1/NR2F2/FSTL3/NASP/IDH1/CTSV/HSPA5/ATRX/ADAMTS1/RDH10/BCL2/CEBPB/ARID5B/EIF2S2/KDM5A/INHA/RHOBTB3/ZFX/CYP19A1 22 GO:0048863 stem cell differentiation 21/725 206/18722 5.2761070870963e-05 0.00228586212175138 NRP2/SEMA6D/SEMA6A/KRT18/MSI2/PRKDC/LAMA5/ISL1/RBPJ/NFE2L2/PDCD6/N4BP2L2/BMP7/DHX36/PUM1/RDH10/UFL1/HES1/SETD2/TACSTD2/SEMA4C 21 GO:0036294 cellular response to decreased oxygen levels 18/725 161/18722 5.3718434335221e-05 0.00228926289053004 MALAT1/PMAIP1/RBPJ/NFE2L2/DNMT3A/ENO1/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/CPEB4/ERO1A/CFLAR/CHCHD2/BACH1 18 GO:0071496 cellular response to external stimulus 28/725 320/18722 5.37428060708373e-05 0.00228926289053004 ATP2B1/FOS/DAG1/JUN/PMAIP1/TMEM150C/HSPA8/EGFR/GJA1/UPP1/NFE2L2/GLUL/CTSV/HSPA5/TFEB/BCL2/PLEC/HNRNPA1/SLC9A1/MDM2/RALB/CPEB4/CDKN1A/ENG/RAC1/ATF3/MAP1LC3B/CYBA 28 GO:0060411 cardiac septum morphogenesis 11/725 68/18722 5.57077610438833e-05 0.00232982367787256 NRP2/LRP2/TGFBR3/TBX3/ISL1/RBPJ/SOX4/BMP7/MDM2/HES1/ENG 11 GO:0009791 post-embryonic development 12/725 80/18722 5.58384287263351e-05 0.00232982367787256 FBN1/EFEMP1/ATRX/ASH1L/BCL2/ARID5B/CCDC47/C12orf57/AGO2/KDM5B/ZFX/SERP1 12 GO:0001889 liver development 17/725 147/18722 5.60738782206456e-05 0.00232982367787256 RPL19/KRT18/TGFBR3/EGFR/ANXA1/MET/RPS16/GLI3/NF1/COBL/CSNK2B/CEBPB/ARID5B/HRAS/UPF2/HES1/CFLAR 17 GO:0046887 positive regulation of hormone secretion 16/725 133/18722 5.70616489612394e-05 0.002336777354871 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/GLUL/C1QTNF1/MPC2/INHA/SRI/SERP1/PHPT1/RAC1/CYP19A1 16 GO:0098901 regulation of cardiac muscle cell action potential 7/725 27/18722 5.7163225883607e-05 0.002336777354871 AKAP9/CAV1/CALM1/DSG2/GJA5/DLG1/DSC2 7 GO:0009410 response to xenobiotic stimulus 36/725 462/18722 5.85333062352814e-05 0.00235718319213832 LDHA/PLIN2/CYP2J2/FOS/TFRC/JUN/HSPD1/EGFR/CDH1/FOSB/ANXA1/DUSP6/PGF/GNA12/TXNIP/PNP/NFE2L2/ABCB1/DNMT3A/RHOA/SLC6A4/PDE4B/RPN2/HSPA5/BCL2/MDM2/CAT/HADHA/ADIRF/CDKN1A/CENPF/ENG/TIMP2/GSTO1/B2M/CYBA 36 GO:0016055 Wnt signaling pathway 35/725 444/18722 5.8592440759406e-05 0.00235718319213832 WLS/CAV1/LRP1/LGR5/LGR4/TLE4/KANK1/APP/PLPP3/DDB1/EGFR/MACF1/ISL1/RNF43/RPS12/RBPJ/CTNND1/ZNRF3/SOX4/GLI3/RHOA/LRP5/GPC3/TBL1X/CSNK2B/BRD7/LATS2/GNAQ/TLE1/ATP6AP2/RTF1/CDC42/DDIT3/ZNF703/RAC1 35 GO:0032956 regulation of actin cytoskeleton organization 30/725 357/18722 6.22167351772985e-05 0.00247581111993761 IQGAP2/LRP1/KANK1/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/JAM3/ACTG1/ROCK1/WASF2/SLC9A1/DLG1/RHOB/IQGAP1/ARPC3/PHLDB2/PFN1/MTSS1/CDC42/HRAS/RHOBTB3/RASA1/TACSTD2/PHPT1/RAC1/ARF1/CAPZB 30 GO:0061041 regulation of wound healing 16/725 134/18722 6.25180160489275e-05 0.00247581111993761 CAV1/ITGB1/KANK1/PLPP3/GJA1/ANXA1/NFE2L2/ACTG1/CLDN4/PHLDB2/C1QTNF1/SRSF6/HRAS/HMGB1/SERPINB2/SERPINE1 16 GO:0045665 negative regulation of neuron differentiation 11/725 69/18722 6.39870223342241e-05 0.00250085325810158 APP/ISL1/GLI3/PBX1/RHOA/SLC6A4/BMP7/SPAG9/MIB1/HES1/B2M 11 GO:0198738 cell-cell signaling by wnt 35/725 446/18722 6.41370928295927e-05 0.00250085325810158 WLS/CAV1/LRP1/LGR5/LGR4/TLE4/KANK1/APP/PLPP3/DDB1/EGFR/MACF1/ISL1/RNF43/RPS12/RBPJ/CTNND1/ZNRF3/SOX4/GLI3/RHOA/LRP5/GPC3/TBL1X/CSNK2B/BRD7/LATS2/GNAQ/TLE1/ATP6AP2/RTF1/CDC42/DDIT3/ZNF703/RAC1 35 GO:0061326 renal tubule development 13/725 94/18722 6.61130968038767e-05 0.00254681996215415 LGR5/LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/MTSS1/HES1/TACSTD2 13 GO:0034284 response to monosaccharide 22/725 225/18722 6.63208196891591e-05 0.00254681996215415 LDHA/DYNLL1/LRP1/KRT18/KIF5B/GJA1/TXNIP/SOX4/RHOA/LRP5/GLUL/CTSV/TRA2B/CAT/HMGN3/MPC2/SERPINF1/VAMP2/SRI/PHPT1/RAC1/CYBA 22 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 9/725 47/18722 6.77317584826086e-05 0.00258144574246875 JUN/RBPJ/NFE2L2/HSPA5/CEBPB/HSPA1A/DDIT3/BACH1/ATF3 9 GO:0010632 regulation of epithelial cell migration 26/725 292/18722 7.37099620021594e-05 0.00278612170599343 NRP2/PLPP3/ANXA1/MET/NR2F2/MACF1/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/CSNK2B/LGMN/RHOB/PFN1/SERPINF1/SASH1/TACSTD2/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 26 GO:0045927 positive regulation of growth 24/725 259/18722 7.42013080112672e-05 0.00278612170599343 IGF2/LRP1/BASP1/S100A9/TGFBR3/PRKDC/EGFR/MACF1/RBPJ/CSH1/GOLGA4/EZR/RHOA/TFCP2L1/BCL2/GHR/SLC9A1/NIPBL/CDC42/HOPX/RAB11A/SERP1/SDCBP/CYBA 24 GO:0045137 development of primary sexual characteristics 22/725 227/18722 7.56688453052115e-05 0.00282033365332439 BASP1/ADGRG1/LRP2/SF1/NR2F2/FSTL3/NASP/IDH1/CTSV/HSPA5/ATRX/ADAMTS1/RDH10/BCL2/CEBPB/ARID5B/EIF2S2/KDM5A/INHA/RHOBTB3/ZFX/CYP19A1 22 GO:0031032 actomyosin structure organization 20/725 196/18722 7.78588131079442e-05 0.00286649318214095 KRT19/KRT8/ITGB1/MYH10/FRMD6/MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/PLEC/SLC9A1/PHLDB2/PFN1/CDC42/EPB41L3/TACSTD2/CFLAR/RAC1 20 GO:0051047 positive regulation of secretion 27/725 310/18722 7.85653311449092e-05 0.00286649318214095 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ISL1/EZR/SOX4/SLC6A4/GLUL/SYT7/C1QTNF1/MPC2/EXOC1/INHA/SRI/SERP1/PHPT1/RAC1/CYP19A1/ARF1/PPIA/SDCBP/CYBA 27 GO:0071456 cellular response to hypoxia 17/725 151/18722 7.8718621174155e-05 0.00286649318214095 MALAT1/PMAIP1/RBPJ/NFE2L2/DNMT3A/ENO1/BMP7/BNIP3L/P4HB/HP1BP3/BCL2/SLC9A1/MDM2/ERO1A/CFLAR/CHCHD2/BACH1 17 GO:0006457 protein folding 21/725 212/18722 8.00286533135286e-05 0.00286649318214095 HSPD1/HSPA8/LMAN1/GRN/HSP90B1/HSPB1/HSPA5/P4HB/NKTR/HSPA1A/PPIG/CCDC47/SIL1/RANBP2/ERO1A/DNAJB14/DNAJB4/PDIA4/ERP29/PPIA/B2M 21 GO:0072009 nephron epithelium development 14/725 109/18722 8.01516397431903e-05 0.00286649318214095 BASP1/LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/IQGAP1/MTSS1/HES1/TACSTD2 14 GO:0090303 positive regulation of wound healing 10/725 59/18722 8.03002627468959e-05 0.00286649318214095 ITGB1/KANK1/PLPP3/ANXA1/NFE2L2/ACTG1/CLDN4/HRAS/HMGB1/SERPINE1 10 GO:0034620 cellular response to unfolded protein 13/725 96/18722 8.25279105882033e-05 0.00292541243896225 HSPD1/HSPA8/NFE2L2/HSPA5/HERPUD1/HSPB8/HSPA1A/UFL1/PPP1R15A/ERO1A/DDIT3/SERP1/ATF3 13 GO:0071248 cellular response to metal ion 20/725 197/18722 8.35815420106919e-05 0.00292767719538735 FOS/APP/FUS/JUN/JUND/EGFR/CDH1/FOSB/PARP1/FSTL3/NFE2L2/HSPA5/LGMN/IQGAP1/SYT7/SERPINF1/TFAP2A/HSD17B1/UBE2D3/B2M 20 GO:0072078 nephron tubule morphogenesis 11/725 71/18722 8.37469310181823e-05 0.00292767719538735 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/HES1/TACSTD2 11 GO:1900115 extracellular regulation of signal transduction 5/725 13/18722 8.52913434940918e-05 0.00293162699704943 FBN1/FBN2/CD46/LRPAP1/LTBP1 5 GO:1900116 extracellular negative regulation of signal transduction 5/725 13/18722 8.52913434940918e-05 0.00293162699704943 FBN1/FBN2/CD46/LRPAP1/LTBP1 5 GO:0061138 morphogenesis of a branching epithelium 19/725 182/18722 8.59656580459535e-05 0.00293162699704943 SPINT1/DLG5/LGR4/DAG1/MAGED1/LAMA5/TBX3/MET/GLI3/PBX1/LRP5/BMP7/GPC3/RDH10/BCL2/DLG1/KDM5B/TACSTD2/ENG 19 GO:0001649 osteoblast differentiation 22/725 229/18722 8.61732930677381e-05 0.00293162699704943 FBN2/RRBP1/IGF2/LGR4/SMOC1/JUND/DDX5/CRIM1/GLI3/IL6ST/LRP5/NF1/BMP7/SUCO/ESRRA/CLTC/CEBPB/UFL1/CCDC47/CAT/TPM4/CLIC1 22 GO:0006091 generation of precursor metabolites and energy 37/725 490/18722 8.91122276054067e-05 0.00301139921154538 GAPDH/LDHA/ALDOA/TPI1/IGF2/UGP2/APP/ACSS1/AGL/PKM/AKR1B1/DHRS2/GLDC/GAA/PHLDA2/CROT/IDH1/PHKB/IL6ST/RHOA/ENO1/OPN3/RPIA/PLEC/COX6A1/CAT/ADH5/ASPH/CYB5A/UQCRH/HMGB1/CHCHD2/SDHA/CYP19A1/FDX1/CHCHD10/CYBA 37 GO:0043542 endothelial cell migration 25/725 279/18722 9.10894370467966e-05 0.00305783017476961 NRP2/ITGB1/PLPP3/EPHB4/ANXA1/MET/NR2F2/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/S100P/CSNK2B/LGMN/RHOB/SERPINF1/SASH1/AMOT/HMGB1/RAC1/PIK3CB 25 GO:0030330 DNA damage response, signal transduction by p53 class mediator 11/725 72/18722 9.54421891020938e-05 0.00318287142472706 MIF/PMAIP1/DDX5/SOX4/PTTG1IP/RPL26/NPM1/ATRX/USP10/MDM2/CDKN1A 11 GO:0045785 positive regulation of cell adhesion 34/725 437/18722 9.60829118843281e-05 0.00318329594994549 CAV1/IGF2/CD46/ADGRG1/UTRN/TFRC/DAG1/ITGAV/CCDC80/PLPP3/HSPD1/ITGA6/ANXA1/TRIOBP/FSTL3/PNP/ZFHX3/SOX4/GLI3/IL6ST/RHOA/BMP7/SOCS1/P4HB/NFAT5/ROCK1/IQGAP1/CD55/CDC42/HES1/RIPK2/HMGB1/RAC1/B2M 34 GO:0009896 positive regulation of catabolic process 37/725 492/18722 9.68502472495022e-05 0.00318788248901121 CAV1/LRP1/LRP2/APP/CTSC/KCNQ1OT1/DDB1/GJA1/BTG2/NFE2L2/EZR/PTTG1IP/BNIP3L/OAZ1/GPC3/DHX36/TFEB/ROCK1/PUM1/LARP1/HERPUD1/HSPB8/HSPA1A/UFL1/MDM2/TNRC6B/RALB/HUWE1/DDA1/UVRAG/PIP4K2A/MYLIP/AGO2/RIPK2/HMGB1/PIK3CB/CBLB 37 GO:0031667 response to nutrient levels 36/725 474/18722 9.84592192708025e-05 0.00321993408053999 LDHA/ATP2B1/JUN/PMAIP1/AGL/KRT18/HSPA8/EGFR/ADRB1/UPP1/CSH1/NFE2L2/DNMT3A/SLC6A4/GLUL/BMP7/CTSV/HSPA5/TFEB/BCL2/LARP1/NUCB2/PLEC/GHR/HNRNPA1/MDM2/CAT/RALB/CPEB4/CDKN1A/GDF15/DDIT3/MBD3/ATF3/MAP1LC3B/CYBA 36 GO:0045216 cell-cell junction organization 20/725 200/18722 0.000103051105844864 0.00332855276776276 CAV1/SVEP1/DLG5/GJA1/CDH1/CTNND1/RHOA/JAM3/DSG2/ACTG1/ROCK1/GJA5/CLDN4/PKN2/PLEC/DLG1/MTSS1/CDC42/EPB41L3/ZNF703 20 GO:1903115 regulation of actin filament-based movement 8/725 39/18722 0.00010309386161743 0.00332855276776276 AKAP9/CAV1/PDE4B/DSG2/GJA5/DLG1/DSC2/SRI 8 GO:0007346 regulation of mitotic cell cycle 35/725 457/18722 0.000104059370934059 0.00333846171686548 IGF2/BRD4/APP/PRKDC/DUSP1/DDB1/EGFR/CTDSPL/BTG3/ANXA1/BTG2/SOX4/RPL26/PBX1/LRP5/BMP7/ADAMTS1/BRD7/PPP1R10/BCL2/LGMN/PKN2/USP22/DLG1/MDM2/IQGAP1/CDC42/NEK6/CDKN1A/HES1/RAB11A/CDKN1C/CENPF/TIMP2/SDCBP 35 GO:0007369 gastrulation 19/725 185/18722 0.000106993568624648 0.00338155383209048 WLS/ITGB1/ITGB4/DAG1/ITGAV/LAMB1/DUSP1/GJA1/RPS6/LRP5/BMP7/GPC3/APELA/COL4A2/PHLDB2/RTF1/TXNRD1/AMOT/SETD2 19 GO:0040014 regulation of multicellular organism growth 10/725 61/18722 0.000107498495119656 0.00338155383209048 IGF2/APP/ADRB1/EZR/BCL2/AFG3L2/LGMN/GHR/NIPBL/GDF15 10 GO:0042274 ribosomal small subunit biogenesis 11/725 73/18722 0.000108503819066202 0.00338155383209048 RPS21/PRKDC/RPS6/RPS16/RPS8/RPS25/RPS19/NPM1/RPS5/SNU13/RPSA 11 GO:0072088 nephron epithelium morphogenesis 11/725 73/18722 0.000108503819066202 0.00338155383209048 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/HES1/TACSTD2 11 GO:0042254 ribosome biogenesis 26/725 299/18722 0.000108738069566137 0.00338155383209048 RPLP0/RPL24/RPL23A/RPS21/RPL14/PRKDC/RPS6/RPL6/RPS16/RPS8/RPS25/RPL10/RPL26/RPS19/GLUL/NPM1/RPS5/RPL10A/RPL3/DDX17/RPL7A/RPL7/RPL27/SNU13/NOP10/RPSA 26 GO:0007015 actin filament organization 34/725 441/18722 0.000114542501065623 0.00352317037177079 ALDOA/IQGAP2/KANK1/ARHGAP18/MET/TRIOBP/TMSB4X/EZR/HSP90B1/RHOA/PPP1R9A/COBL/DIAPH2/ACTG1/ROCK1/WASF2/BCL2/CFL1/PLEC/SLC9A1/DLG1/RHOB/ARPC3/PHLDB2/PFN1/MTSS1/CDC42/RHOBTB3/RASA1/TACSTD2/TPM4/RAC1/ARF1/CAPZB 34 GO:0048864 stem cell development 12/725 86/18722 0.000114682010523216 0.00352317037177079 NRP2/SEMA6D/SEMA6A/MSI2/LAMA5/ISL1/PDCD6/BMP7/RDH10/HES1/SETD2/SEMA4C 12 GO:0007163 establishment or maintenance of cell polarity 21/725 218/18722 0.000119169075130363 0.00363896410744464 ITGB1/DLG5/KANK1/GJA1/DST/RHOA/JAM3/FRMD4B/ROCK1/SLC9A1/DLG1/GPSM2/RHOB/CDC42/RHOBTB3/HES1/AMOT/NUMA1/SNX27/ARF4/RAC1 21 GO:0003151 outflow tract morphogenesis 11/725 74/18722 0.000123059265112213 0.00373494319172568 NRP2/LRP2/TGFBR3/TBX3/ISL1/RBPJ/BMP7/GJA5/NIPBL/HES1/ENG 11 GO:0060675 ureteric bud morphogenesis 10/725 62/18722 0.000123785846559462 0.00373494319172568 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/BCL2/DLG1/HES1/TACSTD2 10 GO:0048736 appendage development 18/725 172/18722 0.00012683975411549 0.00376845515894426 FBN2/ITGB4/SMOC1/ITGA6/TBX3/NR2F2/ZNRF3/SOX4/GLI3/PBX1/LRP5/BMP7/GPC3/ATRX/FRAS1/RDH10/NIPBL/TFAP2A 18 GO:0060173 limb development 18/725 172/18722 0.00012683975411549 0.00376845515894426 FBN2/ITGB4/SMOC1/ITGA6/TBX3/NR2F2/ZNRF3/SOX4/GLI3/PBX1/LRP5/BMP7/GPC3/ATRX/FRAS1/RDH10/NIPBL/TFAP2A 18 GO:0009746 response to hexose 21/725 219/18722 0.000127126816369988 0.00376845515894426 LDHA/DYNLL1/LRP1/KRT18/KIF5B/GJA1/TXNIP/SOX4/RHOA/LRP5/GLUL/CTSV/TRA2B/HMGN3/MPC2/SERPINF1/VAMP2/SRI/PHPT1/RAC1/CYBA 21 GO:0002244 hematopoietic progenitor cell differentiation 14/725 114/18722 0.000130826655819149 0.00384464803636872 RBM47/PRKDC/PRRC2C/FSTL3/ZFAT/NFE2L2/SOX4/JAM3/N4BP2L2/DHX36/BCL2/UFL1/HES1/FLT1 14 GO:0007265 Ras protein signal transduction 28/725 337/18722 0.000131214067921047 0.00384464803636872 ITGB1/ADGRG1/KANK1/JUN/DHCR24/HACD3/MET/GNA12/EPS8L1/RHOA/NF1/ROCK1/WASF2/CFL1/GPSM2/RHOB/NET1/RALB/KPNB1/CDC42/HRAS/CDKN1A/DNMT1/RASA1/RAC1/PIK3CB/TIMP2/SDCBP 28 GO:0048568 embryonic organ development 33/725 427/18722 0.00013741453258599 0.00398972626305492 KRT19/FBN1/FBN2/KRT8/SPINT1/IGF2/EFEMP1/TBX3/NR2F2/RBPJ/TRIOBP/PHLDA2/RPL10/GLI3/PBX1/BMP7/COBL/BPTF/MIB1/TRA2B/TFEB/RDH10/CEBPB/TEAD1/APELA/DLG1/NIPBL/BIRC6/TFAP2A/HES1/SETD2/ENG/MBD3 33 GO:0040013 negative regulation of locomotion 31/725 391/18722 0.000137739612553681 0.00398972626305492 TCAF1/FBLN1/LRP1/DLG5/ADGRG1/KANK1/MIF/SEMA6D/DAG1/SEMA6A/IGFBP3/DUSP1/GJA1/CDH1/NR2F2/GNA12/ARRDC3/NFE2L2/RHOA/NF1/CSNK2B/BCL2/RHOB/PHLDB2/SERPINF1/TACSTD2/SEMA4C/HMGB1/SERPINE1/ENG/RAC1 31 GO:0009743 response to carbohydrate 23/725 253/18722 0.000138607474808012 0.00399205278296485 LDHA/DYNLL1/LRP1/KRT18/KIF5B/GJA1/TXNIP/SOX4/RHOA/LRP5/GLUL/COLEC12/CTSV/TRA2B/CAT/HMGN3/MPC2/SERPINF1/VAMP2/SRI/PHPT1/RAC1/CYBA 23 GO:0006979 response to oxidative stress 34/725 446/18722 0.000142081013741671 0.00402430206819878 GPX3/LDHA/PRDX6/FOS/APP/JUN/SOD3/DHCR24/HSPD1/DUSP1/EGFR/DHRS2/ANXA1/MET/PARP1/TXNIP/NFE2L2/IDH1/HSPB1/BMP7/P4HB/TRA2B/BCL2/GPX4/ARL6IP5/FUT8/HSPA1A/MDM2/RHOB/CAT/NET1/ERO1A/CHCHD2/PPIA 34 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 10/725 63/18722 0.000142108911068767 0.00402430206819878 PMAIP1/BCL2/CEBPB/HERPUD1/HSPA1A/PPP1R15A/ERO1A/GRINA/ERP29/DDIT3 10 GO:0072171 mesonephric tubule morphogenesis 10/725 63/18722 0.000142108911068767 0.00402430206819878 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/BCL2/DLG1/HES1/TACSTD2 10 GO:0051412 response to corticosterone 6/725 22/18722 0.000144751447706683 0.00407636160236208 ATP2B1/FOS/FOSB/CALM1/HSD3B1/CDKN1A 6 GO:1900027 regulation of ruffle assembly 7/725 31/18722 0.000147896744645012 0.00414192595914676 CAV1/KANK1/EPS8L1/COBL/PFN1/HRAS/TACSTD2 7 GO:1903311 regulation of mRNA metabolic process 25/725 288/18722 0.000150517346353728 0.00419215620146728 PRDX6/SON/FUS/RBM39/HSPA8/SF1/DDX5/BTG2/SAP18/NPM1/RBM25/DHX36/SRSF9/TRA2B/ROCK1/PUM1/SRSF7/LARP1/HNRNPA1/TNRC6B/DDX17/QKI/SRSF6/AGO2/YBX1 25 GO:0031103 axon regeneration 9/725 52/18722 0.000153868080185192 0.00425281185791213 LRP1/DAG1/ISL1/GRN/JAM3/MTR/NREP/BCL2/PTPRF 9 GO:0008016 regulation of heart contraction 20/725 206/18722 0.000154373127215591 0.00425281185791213 ATP2B1/CYP2J2/AKAP9/CAV1/ADRB1/GJA1/GAA/CALM1/ISL1/PDE4B/DSG2/GJA5/APELA/SLC9A1/DLG1/MDM2/DSC2/HOPX/SRI/GSTO1 20 GO:0035967 cellular response to topologically incorrect protein 14/725 116/18722 0.000157783579904611 0.00428323233105136 HSPD1/HSPA8/NFE2L2/HSPA5/HERPUD1/HSPB8/HSPA1A/UFL1/PPP1R15A/ERO1A/DNAJB14/DDIT3/SERP1/ATF3 14 GO:0009914 hormone transport 26/725 306/18722 0.000157955096667128 0.00428323233105136 DYNLL1/LRP1/KIF5B/EGFR/GJA1/TBX3/ANXA1/ISL1/SOX4/LRP5/GLUL/RAB11FIP1/CAMK2G/SYT7/C1QTNF1/HMGN3/MPC2/INHA/KDM5B/SRI/SERP1/RAB1A/PHPT1/RAC1/CYP19A1/SLC7A5 26 GO:0052126 movement in host environment 18/725 175/18722 0.000158012319176683 0.00428323233105136 CAV1/ITGB1/CD46/TFRC/DAG1/ITGAV/DDB1/EGFR/CTSL/P4HB/SLC52A1/HSPA1A/CD55/UVRAG/LY6E/PPIA/ARL8B/RPSA 18 GO:0014910 regulation of smooth muscle cell migration 12/725 89/18722 0.000160183341535541 0.00431898594810456 LRP1/S100A11/SEMA6D/IGFBP3/GNA12/NFE2L2/RHOA/ADAMTS1/BCL2/MDM2/IQGAP1/SERPINE1 12 GO:0044403 biological process involved in symbiotic interaction 25/725 290/18722 0.000167676503859066 0.00449710157704553 GAPDH/SERPINB9/CAV1/ITGB1/CD46/TFRC/DAG1/JUN/ITGAV/HSPD1/HSPA8/DDB1/EGFR/STOM/CTSL/P4HB/SLC52A1/CFL1/HSPA1A/CD55/UVRAG/LY6E/PPIA/ARL8B/RPSA 25 GO:0010634 positive regulation of epithelial cell migration 18/725 176/18722 0.000169799733154212 0.00453007814399316 NRP2/PLPP3/ANXA1/MET/TMSB4X/NFE2L2/PDCD6/GRN/HSPB1/LGMN/RHOB/PFN1/SASH1/RAB11A/RTN4/HMGB1/RAC1/PIK3CB 18 GO:0090277 positive regulation of peptide hormone secretion 13/725 103/18722 0.000170809513655532 0.00453315929172718 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/GLUL/MPC2/SRI/SERP1/PHPT1/RAC1 13 GO:0055117 regulation of cardiac muscle contraction 11/725 77/18722 0.000177094569795272 0.00467548111610538 AKAP9/CAV1/CALM1/PDE4B/DSG2/GJA5/SLC9A1/DLG1/DSC2/SRI/GSTO1 11 GO:0034109 homotypic cell-cell adhesion 12/725 90/18722 0.000178431760629189 0.00467654549779477 PLPP3/IL6ST/HSPB1/DSG2/ACTG1/DSC2/C1QTNF1/CLIC1/CD99/ZNF703/PIK3CB/PPIA 12 GO:0043620 regulation of DNA-templated transcription in response to stress 9/725 53/18722 0.000179056783046011 0.00467654549779477 JUN/RBPJ/NFE2L2/HSPA5/CEBPB/HSPA1A/DDIT3/BACH1/ATF3 9 GO:0016032 viral process 32/725 415/18722 0.000179902618281709 0.00467654549779477 CAV1/ITGB1/CD46/TFRC/DAG1/JUN/ITGAV/HACD3/HSPA8/DDB1/EGFR/DDX5/STOM/MPHOSPH8/CTSL/P4HB/BCL2/LARP1/PKN2/SLC52A1/FUT8/CFL1/HSPA1A/DEK/CD55/CDC42/UVRAG/LY6E/RAB1A/PPIA/ARL8B/RPSA 32 GO:0051235 maintenance of location 27/725 326/18722 0.000181070861511337 0.00468289896429065 PLIN2/FBN1/FBN2/AKAP9/CAV1/ITGAV/S100A9/FTH1/GJA1/GAA/CALM1/TMSB4X/HSP90B1/SKP1/HSPA5/LTBP1/GOPC/GPSM2/CDS1/ERO1A/UVRAG/KDELR2/DDIT3/SRI/CHCHD10/GSTO1/CYBA 27 GO:0003012 muscle system process 34/725 452/18722 0.000182892872812136 0.00468590732917467 ALDOA/ATP2B1/AKAP9/CAV1/UTRN/DAG1/GJA1/TBX3/SLC6A8/GAA/CALM1/PARP1/IL6ST/RHOA/ENO1/PDE4B/MYL6/HOMER1/DSG2/ROCK1/GJA5/PABPN1/CAMK2G/SLC9A1/DLG1/DSC2/ASPH/C12orf57/CFLAR/TPM4/SRI/ARG2/GSTO1/CYBA 34 GO:0051642 centrosome localization 7/725 32/18722 0.00018303603298019 0.00468590732917467 AKAP9/SYNE2/KIF5B/EZR/DLG1/GPSM2/RANBP2 7 GO:0007565 female pregnancy 19/725 193/18722 0.00018677760253474 0.00475766666959093 SYDE1/FBLN1/ITGB4/FOS/AKR1B1/GJA1/FOSB/RPL29/SLC38A1/NR2F2/PGF/CTSV/ASH1L/BCL2/CLDN4/APELA/MAGED2/AGO2/UBE2A 19 GO:1902850 microtubule cytoskeleton organization involved in mitosis 16/725 147/18722 0.000188146839620784 0.00476858165018877 ITGB1/GJA1/TACC2/RHOA/DYNC1H1/CLTC/HSPA1A/GPSM2/KPNB1/STAG1/NEK6/NUMA1/SETD2/RAB11A/CCSAP/DCTN6 16 GO:0006413 translational initiation 14/725 118/18722 0.000189410336743186 0.00477672137786671 RPS3A/EIF4H/NPM1/HSPB1/RPL13A/RPS5/LARP1/EIF2S2/PPP1R15A/EIF1/AGO2/EIF3H/EIF3I/PAIP2 14 GO:0051098 regulation of binding 29/725 363/18722 0.000196838574675428 0.00489813036732547 C4orf3/CAV1/LRP1/APP/JUN/TGFBR3/MET/CALM1/ISL1/PARP1/PHLDA2/TMSB4X/EDF1/LRPAP1/CSNK2B/ROCK1/CCPG1/PTPRF/RALB/CDC42/HOPX/CDKN1A/HES1/DDIT3/RIPK2/HMGB1/SRI/B2M/CBLB 29 GO:0051492 regulation of stress fiber assembly 12/725 91/18722 0.000198425542904217 0.00489813036732547 MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/CDC42/TACSTD2/RAC1 12 GO:0072080 nephron tubule development 12/725 91/18722 0.000198425542904217 0.00489813036732547 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/IRX2/BCL2/DLG1/MTSS1/HES1/TACSTD2 12 GO:0010595 positive regulation of endothelial cell migration 15/725 133/18722 0.000199918561345796 0.00489813036732547 NRP2/PLPP3/ANXA1/MET/TMSB4X/NFE2L2/PDCD6/GRN/HSPB1/LGMN/RHOB/SASH1/HMGB1/RAC1/PIK3CB 15 GO:0030111 regulation of Wnt signaling pathway 27/725 328/18722 0.000199971833567876 0.00489813036732547 WLS/CAV1/LRP1/LGR5/LGR4/TLE4/KANK1/APP/PLPP3/EGFR/MACF1/ISL1/RNF43/RPS12/RBPJ/CTNND1/ZNRF3/SOX4/GLI3/GPC3/TBL1X/LATS2/GNAQ/TLE1/ATP6AP2/DDIT3/ZNF703 27 GO:0031396 regulation of protein ubiquitination 20/725 210/18722 0.000200022289610648 0.00489813036732547 CAV1/ARRDC3/RPS2/PDCD6/SOX4/PTTG1IP/SKP1/NPM1/MYCBP2/HSPA5/TRIM44/HERPUD1/HSPA1A/UFL1/RPS20/HUWE1/SASH1/RIPK2/PPIA/CBLB 20 GO:0032231 regulation of actin filament bundle assembly 13/725 105/18722 0.000207578202311785 0.00505872070922326 MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/MTSS1/CDC42/TACSTD2/RAC1 13 GO:0051893 regulation of focal adhesion assembly 10/725 66/18722 0.000211350673591034 0.00510160268777597 LRP1/MACF1/RHOA/PTPRA/ACTG1/ROCK1/SLC9A1/IQGAP1/PHLDB2/RAC1 10 GO:0090109 regulation of cell-substrate junction assembly 10/725 66/18722 0.000211350673591034 0.00510160268777597 LRP1/MACF1/RHOA/PTPRA/ACTG1/ROCK1/SLC9A1/IQGAP1/PHLDB2/RAC1 10 GO:0006936 muscle contraction 28/725 347/18722 0.000213885380936831 0.0051383175164398 ALDOA/ATP2B1/AKAP9/CAV1/UTRN/GJA1/TBX3/SLC6A8/GAA/CALM1/RHOA/ENO1/PDE4B/MYL6/HOMER1/DSG2/ROCK1/GJA5/PABPN1/SLC9A1/DLG1/DSC2/ASPH/C12orf57/TPM4/SRI/ARG2/GSTO1 28 GO:0046879 hormone secretion 25/725 295/18722 0.000218404754160145 0.00522214008885742 DYNLL1/LRP1/KIF5B/EGFR/GJA1/TBX3/ANXA1/ISL1/SOX4/LRP5/GLUL/RAB11FIP1/CAMK2G/SYT7/C1QTNF1/HMGN3/MPC2/INHA/KDM5B/SRI/SERP1/RAB1A/PHPT1/RAC1/CYP19A1 25 GO:0022898 regulation of transmembrane transporter activity 24/725 278/18722 0.000219949326111244 0.00523438091106994 TCAF1/C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/APP/KIF5B/GJA1/STOM/CALM1/TMSB4X/ABCB1/PDE4B/HOMER1/BCL2/GOPC/SLC9A1/DLG1/VAMP2/SRI/GLRX/GSTO1 24 GO:0034329 cell junction assembly 32/725 420/18722 0.000223188463892987 0.00528664637137174 CAV1/ITGB4/LRP1/DLG5/APP/LAMC1/ITGA6/GJA1/DST/CDH1/MACF1/CTNND1/RHOA/PTPRA/PPP1R9A/JAM3/ACTG1/ROCK1/GJA5/BCL2/CLDN4/PKN2/PLEC/SLC9A1/DLG1/IQGAP1/PHLDB2/CDC42/EPB41L3/ZNF703/RAC1/SDCBP 32 GO:0061842 microtubule organizing center localization 7/725 33/18722 0.000224622947576055 0.00529587777331637 AKAP9/SYNE2/KIF5B/EZR/DLG1/GPSM2/RANBP2 7 GO:0009749 response to glucose 20/725 212/18722 0.000227004584797536 0.00532725111267922 LDHA/DYNLL1/LRP1/KIF5B/GJA1/TXNIP/SOX4/RHOA/LRP5/GLUL/CTSV/TRA2B/HMGN3/MPC2/SERPINF1/VAMP2/SRI/PHPT1/RAC1/CYBA 20 GO:0002793 positive regulation of peptide secretion 13/725 106/18722 0.000228374942834334 0.00533471237431908 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/GLUL/MPC2/SRI/SERP1/PHPT1/RAC1 13 GO:0071772 response to BMP 17/725 165/18722 0.000233510257180459 0.00540485613537784 FBN1/SPINT1/LRP2/TGFBR3/DDX5/PDCD4/RBPJ/FSTL3/CRIM1/BMP7/GPC3/HES1/NUMA1/USP9X/GDF15/UBE2D3/ENG 17 GO:0071773 cellular response to BMP stimulus 17/725 165/18722 0.000233510257180459 0.00540485613537784 FBN1/SPINT1/LRP2/TGFBR3/DDX5/PDCD4/RBPJ/FSTL3/CRIM1/BMP7/GPC3/HES1/NUMA1/USP9X/GDF15/UBE2D3/ENG 17 GO:0051271 negative regulation of cellular component movement 29/725 367/18722 0.000236810569933122 0.00545633081359544 TCAF1/FBLN1/LRP1/DLG5/ADGRG1/KANK1/MIF/SEMA6D/DAG1/TGFBR3/IGFBP3/DUSP1/GJA1/CDH1/NR2F2/GNA12/NFE2L2/RHOA/NF1/CSNK2B/BCL2/RHOB/PHLDB2/SERPINF1/TACSTD2/HMGB1/SERPINE1/ENG/RAC1 29 GO:0003229 ventricular cardiac muscle tissue development 9/725 55/18722 0.000239791639772921 0.00549486164527496 LRP2/TGFBR3/TBX3/ISL1/RBPJ/DSG2/HOPX/LY6E/ENG 9 GO:0051651 maintenance of location in cell 20/725 213/18722 0.000241655152954631 0.00549486164527496 AKAP9/CAV1/S100A9/FTH1/GJA1/GAA/CALM1/TMSB4X/HSP90B1/SKP1/HSPA5/GPSM2/ERO1A/UVRAG/KDELR2/DDIT3/SRI/CHCHD10/GSTO1/CYBA 20 GO:0051402 neuron apoptotic process 22/725 246/18722 0.000242377925880007 0.00549486164527496 GAPDH/LRP1/APP/JUN/HSPD1/BTG2/ISL1/PARP1/GRN/RHOA/NF1/HSPA5/BCL2/LGMN/CEBPB/USP53/CDC42/CPEB4/HRAS/TFAP2A/RASA1/DDIT3 22 GO:0045185 maintenance of protein location 12/725 93/18722 0.000244190244591795 0.00549486164527496 FBN1/FBN2/CAV1/GJA1/TMSB4X/SKP1/HSPA5/LTBP1/GOPC/KDELR2/SRI/CHCHD10 12 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 6/725 24/18722 0.000244398952619473 0.00549486164527496 RBPJ/NFE2L2/HSPA5/CEBPB/DDIT3/ATF3 6 GO:0043588 skin development 23/725 263/18722 0.000244986926776907 0.00549486164527496 ITGB4/LGR5/LGR4/DHCR24/ITGA6/EGFR/LAMA5/ANXA1/MET/RBPJ/ARRDC3/TXNIP/OPN3/ASH1L/FRAS1/ROCK1/NCOA3/BCL2/CLDN4/PLEC/FLNB/SRSF6/NUMA1 23 GO:0097178 ruffle assembly 8/725 44/18722 0.000250377830748658 0.00558027549637891 CAV1/KANK1/EPS8L1/COBL/PFN1/HRAS/TACSTD2/RAC1 8 GO:0043112 receptor metabolic process 17/725 166/18722 0.000250996806702385 0.00558027549637891 CAV1/ITGB1/LRP1/CD63/TFRC/RNF43/ZNRF3/EZR/LRPAP1/CLTC/LGMN/APELA/FUT8/UVRAG/MYLIP/ARF1/SDCBP 17 GO:0031098 stress-activated protein kinase signaling cascade 22/725 247/18722 0.000256624267408588 0.00568047341263814 MAP3K4/APP/AKR1B1/HACD3/DUSP1/EGFR/GADD45B/PDCD4/EZR/RHOA/PHLPP1/DUSP9/ARL6IP5/DLG1/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/PPIA/SDCBP 22 GO:0010649 regulation of cell communication by electrical coupling 5/725 16/18722 0.000262735730051769 0.00579046702448877 CAV1/GJA1/CALM1/GJA5/SRI 5 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 7/725 34/18722 0.00027349865499887 0.00596637350332283 MIF/PMAIP1/DDX5/PTTG1IP/RPL26/NPM1/MDM2 7 GO:0034446 substrate adhesion-dependent cell spreading 13/725 108/18722 0.000275361690199385 0.00596637350332283 FBLN1/KANK1/ITGAV/LAMC1/LAMB1/LAMA5/TRIOBP/RHOA/P4HB/CDC42/TACSTD2/RAB1A/RAC1 13 GO:0001658 branching involved in ureteric bud morphogenesis 9/725 56/18722 0.00027603388217623 0.00596637350332283 LGR4/MAGED1/LAMA5/GLI3/PBX1/GPC3/BCL2/DLG1/TACSTD2 9 GO:0010332 response to gamma radiation 9/725 56/18722 0.00027603388217623 0.00596637350332283 PRKDC/PARP1/RPL26/HSPA5/BCL2/MDM2/HRAS/CDKN1A/CYBA 9 GO:0030509 BMP signaling pathway 16/725 152/18722 0.000276602440970776 0.00596637350332283 FBN1/LRP2/TGFBR3/DDX5/PDCD4/RBPJ/FSTL3/CRIM1/BMP7/GPC3/HES1/NUMA1/USP9X/GDF15/UBE2D3/ENG 16 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 11/725 81/18722 0.00027937544088436 0.00600065300780855 PEG10/FBN1/FBN2/CAV1/HTRA4/GLG1/TGFBR3/HSPA5/ZNF451/LTBP1/HSPA1A 11 GO:0010594 regulation of endothelial cell migration 21/725 232/18722 0.000282488172173974 0.00604190947151846 NRP2/PLPP3/ANXA1/MET/NR2F2/TMSB4X/NFE2L2/PDCD6/GRN/RHOA/NF1/GLUL/HSPB1/CSNK2B/LGMN/RHOB/SERPINF1/SASH1/HMGB1/RAC1/PIK3CB 21 GO:0046883 regulation of hormone secretion 22/725 249/18722 0.000287342489673976 0.00611991210150162 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ANXA1/ISL1/SOX4/LRP5/GLUL/RAB11FIP1/SYT7/C1QTNF1/HMGN3/MPC2/INHA/KDM5B/SRI/SERP1/PHPT1/RAC1/CYP19A1 22 GO:0006942 regulation of striated muscle contraction 12/725 95/18722 0.000298634467349632 0.00633379964433173 AKAP9/CAV1/CALM1/PDE4B/DSG2/GJA5/SLC9A1/DLG1/DSC2/C12orf57/SRI/GSTO1 12 GO:0042176 regulation of protein catabolic process 30/725 391/18722 0.000308253050152876 0.00651056129677054 EEF1A1/CAV1/LRP1/LRP2/CTSC/DDB1/EGFR/GJA1/CDH1/PSMD1/GNA12/NFE2L2/EZR/PTTG1IP/MYCBP2/OAZ1/GPC3/ROCK1/HERPUD1/HSPA1A/UFL1/MDM2/HUWE1/DDA1/MYLIP/EIF3H/TIMP3/TIMP2/SDCBP/CBLB 30 GO:1905897 regulation of response to endoplasmic reticulum stress 11/725 82/18722 0.000311573250548934 0.00655338094204376 CAV1/PMAIP1/NFE2L2/HSPA5/HERPUD1/HSPA1A/UFL1/PPP1R15A/GRINA/ERP29/DDIT3 11 GO:1904375 regulation of protein localization to cell periphery 14/725 125/18722 0.000346882092910935 0.00726588978911375 ITGB1/LRP1/DAG1/KIF5B/EGFR/EZR/CLTC/GOPC/DLG1/GPSM2/HRAS/NUMA1/RAB11A/TMBIM1 14 GO:0051701 biological process involved in interaction with host 19/725 203/18722 0.000356540692048225 0.00742628651531445 SERPINB9/CAV1/ITGB1/CD46/TFRC/DAG1/ITGAV/DDB1/EGFR/CTSL/P4HB/SLC52A1/HSPA1A/CD55/UVRAG/LY6E/PPIA/ARL8B/RPSA 19 GO:0060828 regulation of canonical Wnt signaling pathway 22/725 253/18722 0.000358604190144425 0.00742628651531445 WLS/CAV1/LGR5/LGR4/TLE4/KANK1/EGFR/ISL1/RPS12/RBPJ/CTNND1/ZNRF3/SOX4/GLI3/GPC3/TBL1X/LATS2/GNAQ/TLE1/ATP6AP2/DDIT3/ZNF703 22 GO:0001780 neutrophil homeostasis 5/725 17/18722 0.000360399779595059 0.00742628651531445 ANXA1/JAM3/PDE4B/HMGB1/PIK3CB 5 GO:0061450 trophoblast cell migration 5/725 17/18722 0.000360399779595059 0.00742628651531445 SYDE1/ITGB4/GJA1/APELA/AGO2 5 GO:0014909 smooth muscle cell migration 12/725 97/18722 0.000363039719053624 0.00745039812098307 LRP1/S100A11/SEMA6D/IGFBP3/GNA12/NFE2L2/RHOA/ADAMTS1/BCL2/MDM2/IQGAP1/SERPINE1 12 GO:0044706 multi-multicellular organism process 20/725 220/18722 0.000369493598668417 0.00748289091534031 SYDE1/FBLN1/ITGB4/FOS/AKR1B1/GJA1/FOSB/RPL29/SLC38A1/NR2F2/PGF/SLC6A4/CTSV/ASH1L/BCL2/CLDN4/APELA/MAGED2/AGO2/UBE2A 20 GO:0009267 cellular response to starvation 16/725 156/18722 0.000371325142921684 0.00748289091534031 JUN/PMAIP1/HSPA8/UPP1/NFE2L2/GLUL/CTSV/HSPA5/TFEB/BCL2/HNRNPA1/RALB/CPEB4/CDKN1A/ATF3/MAP1LC3B 16 GO:0009306 protein secretion 28/725 359/18722 0.000372004046294291 0.00748289091534031 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ANXA1/ISL1/EZR/SOX4/LRP5/GLUL/RAB11FIP1/CAMK2G/SYT7/HMGN3/MPC2/EXOC1/PDIA4/ERP29/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 28 GO:0071900 regulation of protein serine/threonine kinase activity 28/725 359/18722 0.000372004046294291 0.00748289091534031 CAV1/IGF2/MAP3K4/DUSP1/MAGED1/EGFR/CALM1/NR2F2/PDCD4/RHOA/LRP5/NF1/BMP7/CCNL1/PKIB/LATS2/SERTAD1/GHR/IQGAP1/RALB/SASH1/HRAS/UVRAG/CDKN1A/ERP29/CDKN1C/FLT1/PIK3CB 28 GO:2000146 negative regulation of cell motility 28/725 359/18722 0.000372004046294291 0.00748289091534031 TCAF1/FBLN1/LRP1/DLG5/ADGRG1/KANK1/MIF/SEMA6D/DAG1/IGFBP3/DUSP1/GJA1/CDH1/NR2F2/GNA12/NFE2L2/RHOA/NF1/CSNK2B/BCL2/RHOB/PHLDB2/SERPINF1/TACSTD2/HMGB1/SERPINE1/ENG/RAC1 28 GO:0150116 regulation of cell-substrate junction organization 10/725 71/18722 0.000388821418462992 0.00773361741662512 LRP1/MACF1/RHOA/PTPRA/ACTG1/ROCK1/SLC9A1/IQGAP1/PHLDB2/RAC1 10 GO:0035592 establishment of protein localization to extracellular region 28/725 360/18722 0.000388962169552239 0.00773361741662512 DYNLL1/WLS/LRP1/MYH10/KIF5B/EGFR/GJA1/KCNN4/ANXA1/ISL1/EZR/SOX4/LRP5/GLUL/RAB11FIP1/CAMK2G/SYT7/HMGN3/MPC2/EXOC1/PDIA4/ERP29/SRI/SERP1/PHPT1/RAC1/ARF1/PPIA 28 GO:0045765 regulation of angiogenesis 27/725 342/18722 0.000389045658165201 0.00773361741662512 ITGB1/SEMA6A/PKM/ADAM12/ISL1/PGF/NFE2L2/PDCD6/GRN/NF1/GLUL/HSPB1/ADAMTS1/ROCK1/APELA/COL4A2/RHOB/GTF2I/SERPINF1/SASH1/AGO2/AMOT/HMGB1/SERPINE1/ENG/FLT1/PIK3CB 27 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 7/725 36/18722 0.000396797332804537 0.00784739747530127 DYNLL1/LRP1/KIF5B/MPC2/SRI/PHPT1/RAC1 7 GO:0002262 myeloid cell homeostasis 16/725 157/18722 0.00039896531739033 0.00784739747530127 TGFBR3/PRKDC/RPS6/ANXA1/RPS19/JAM3/PDE4B/HSPA1A/UFL1/UBA5/RCOR1/FAM210B/INHA/HMGB1/PIK3CB/B2M 16 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 12/725 98/18722 0.000399413799295271 0.00784739747530127 TPT1/MIF/NFE2L2/PTTG1IP/ENO1/HSPB1/BCL2/HERPUD1/HSPA1A/MDM2/GRINA/PPIA 12 GO:0070997 neuron death 28/725 361/18722 0.000406599372550891 0.00795773057706743 GAPDH/LRP1/FOS/APP/JUN/DHCR24/HSPD1/BTG2/ISL1/PARP1/GRN/RHOA/NF1/HSPA5/BCL2/LGMN/CEBPB/ARL6IP5/GHR/SLC9A1/USP53/SERPINF1/CDC42/CPEB4/HRAS/TFAP2A/RASA1/DDIT3 28 GO:0030048 actin filament-based movement 14/725 127/18722 0.000408569522615972 0.00796553426977063 AKAP9/CAV1/MYH10/SYNE2/GJA1/PDE4B/MYL6/DSG2/GJA5/WASF2/SLC9A1/DLG1/DSC2/SRI 14 GO:1903522 regulation of blood circulation 22/725 256/18722 0.000421774647407955 0.0081914777306932 ATP2B1/CYP2J2/AKAP9/CAV1/EGFR/ADRB1/GJA1/GAA/CALM1/ISL1/RHOA/PDE4B/DSG2/GJA5/APELA/SLC9A1/DLG1/MDM2/DSC2/HOPX/SRI/GSTO1 22 GO:0030336 negative regulation of cell migration 27/725 344/18722 0.00042611732176703 0.008244231694798 TCAF1/LRP1/DLG5/ADGRG1/KANK1/MIF/SEMA6D/DAG1/IGFBP3/DUSP1/GJA1/CDH1/NR2F2/GNA12/NFE2L2/RHOA/NF1/CSNK2B/BCL2/RHOB/PHLDB2/SERPINF1/TACSTD2/HMGB1/SERPINE1/ENG/RAC1 27 GO:0030099 myeloid cell differentiation 29/725 381/18722 0.000439559212521715 0.00847196063981967 FBN1/CSF3R/FOS/APP/TFRC/JUN/TGFBR3/PRKDC/RPS6/DHRS2/PARP1/RBPJ/FSTL3/TET2/RPS19/GPC3/ESRRA/WASF2/CEBPB/HSPA1A/UFL1/UBA5/CDC42/RCOR1/FAM210B/INHA/PIP4K2A/HMGB1/B2M 29 GO:0005996 monosaccharide metabolic process 22/725 257/18722 0.000444890218977499 0.00854222924241266 GAPDH/ALDOA/TPI1/IGF2/PMAIP1/AKR1B1/DDB1/GAA/PHLDA2/LRP5/ENO1/RPIA/SLC35B4/FUT8/RANBP2/C1QTNF1/NCOA2/HMGB1/SERP1/PGM2/ATF3/GSTO1 22 GO:0050679 positive regulation of epithelial cell proliferation 19/725 207/18722 0.000455193418226359 0.00870707712071477 NRP2/IGF2/LAMC1/LAMB1/EGFR/PGF/PDCD6/GRN/GLUL/APELA/SRSF6/CDC42/HRAS/KDM5B/RTN4/CFLAR/HMGB1/ZNF703/CYBA 19 GO:1902903 regulation of supramolecular fiber organization 29/725 382/18722 0.000458661476701609 0.0087404324263175 IQGAP2/AKAP9/KANK1/APP/CLIP1/HSPA8/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/HSPA1A/SLC9A1/DLG1/ARPC3/PHLDB2/PFN1/MTSS1/CDC42/NUMA1/RASA1/TACSTD2/RAC1/ARF1/CAPZB 29 GO:0032409 regulation of transporter activity 25/725 310/18722 0.00046122348553894 0.00875633651010069 TCAF1/C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/APP/KIF5B/GJA1/STOM/CALM1/TMSB4X/ABCB1/PDE4B/HOMER1/BCL2/GOPC/SLC9A1/DLG1/VAMP2/SRI/GLRX/SGK1/GSTO1 25 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/725 114/18722 0.000468825593870378 0.0088185597198143 TGFBR3/PARP1/RBPJ/BMP7/GPC3/CSNK2B/INHA/HES1/NUMA1/CDKN1C/GDF15/ENG/SDCBP 13 GO:0031102 neuron projection regeneration 9/725 60/18722 0.000469362901002681 0.0088185597198143 LRP1/DAG1/ISL1/GRN/JAM3/MTR/NREP/BCL2/PTPRF 9 GO:0060047 heart contraction 21/725 241/18722 0.000470583231985752 0.0088185597198143 ATP2B1/CYP2J2/AKAP9/CAV1/ADRB1/GJA1/GAA/CALM1/ISL1/PDE4B/DSG2/GJA5/APELA/SLC9A1/DLG1/MDM2/DSC2/CDC42/HOPX/SRI/GSTO1 21 GO:0003161 cardiac conduction system development 7/725 37/18722 0.000473219298415121 0.0088185597198143 GJA1/TBX3/ISL1/DSG2/GJA5/CDC42/HOPX 7 GO:0014031 mesenchymal cell development 11/725 86/18722 0.000473371192986263 0.0088185597198143 NRP2/SEMA6D/SEMA6A/LAMA5/ISL1/PDCD6/BMP7/RDH10/BCL2/HES1/SEMA4C 11 GO:0046718 viral entry into host cell 15/725 144/18722 0.000474939199745374 0.0088185597198143 CAV1/ITGB1/CD46/TFRC/DAG1/ITGAV/EGFR/CTSL/P4HB/SLC52A1/HSPA1A/CD55/UVRAG/LY6E/RPSA 15 GO:0110020 regulation of actomyosin structure organization 12/725 100/18722 0.000481451121301766 0.00890684574408267 MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/CDC42/TACSTD2/RAC1 12 GO:0000027 ribosomal large subunit assembly 6/725 27/18722 0.000486793240458809 0.00896527022932046 RPLP0/RPL24/RPL23A/RPL6/RPL10/RPL3 6 GO:0086003 cardiac muscle cell contraction 10/725 73/18722 0.000488146495027115 0.00896527022932046 AKAP9/CAV1/GJA1/PDE4B/DSG2/GJA5/SLC9A1/DLG1/DSC2/SRI 10 GO:0032872 regulation of stress-activated MAPK cascade 18/725 192/18722 0.00049466059239706 0.00905211026303501 MAP3K4/APP/DUSP1/EGFR/GADD45B/PDCD4/EZR/PHLPP1/ARL6IP5/DLG1/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/PPIA/SDCBP 18 GO:1903320 regulation of protein modification by small protein conjugation or removal 21/725 242/18722 0.000497044517782989 0.00906301676489918 CAV1/ARRDC3/RPS2/PDCD6/SOX4/PTTG1IP/SKP1/NPM1/MYCBP2/HSPA5/TRIM44/HMG20B/HERPUD1/HSPA1A/UFL1/RPS20/HUWE1/SASH1/RIPK2/PPIA/CBLB 21 GO:1901342 regulation of vasculature development 27/725 348/18722 0.000509705573385208 0.00926056470067964 ITGB1/SEMA6A/PKM/ADAM12/ISL1/PGF/NFE2L2/PDCD6/GRN/NF1/GLUL/HSPB1/ADAMTS1/ROCK1/APELA/COL4A2/RHOB/GTF2I/SERPINF1/SASH1/AGO2/AMOT/HMGB1/SERPINE1/ENG/FLT1/PIK3CB 27 GO:0110053 regulation of actin filament organization 23/725 277/18722 0.000512231413537265 0.00927321798292999 IQGAP2/KANK1/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/DLG1/ARPC3/PHLDB2/PFN1/MTSS1/CDC42/RASA1/TACSTD2/RAC1/ARF1/CAPZB 23 GO:0048041 focal adhesion assembly 11/725 87/18722 0.00052329769546105 0.00943984348146641 LRP1/MACF1/RHOA/PTPRA/ACTG1/ROCK1/BCL2/SLC9A1/IQGAP1/PHLDB2/RAC1 11 GO:0003205 cardiac chamber development 16/725 161/18722 0.000527971420125993 0.00946559517046798 ADAMTS6/NRP2/LRP2/TGFBR3/TBX3/ISL1/RBPJ/SOX4/BMP7/ADAMTS1/GJA5/MDM2/TRIP11/LY6E/HES1/ENG 16 GO:0045787 positive regulation of cell cycle 25/725 313/18722 0.000531469662956165 0.00946559517046798 IGF2/BRD4/APP/EGFR/TBX3/ANXA1/PBX1/RHOA/LRP5/SLC6A4/NPM1/DYNC1H1/ATRX/ADAMTS1/PPP1R10/LGMN/PKN2/CCPG1/USP22/MDM2/GPSM2/CDC42/HES1/NUMA1/RAB11A 25 GO:0030865 cortical cytoskeleton organization 9/725 61/18722 0.000531993278943973 0.00946559517046798 EZR/RHOA/ROCK1/PLEC/DLG1/RHOB/RHOBTB3/EPB41L3/RAC1 9 GO:0071214 cellular response to abiotic stimulus 26/725 331/18722 0.000534061988312062 0.00946559517046798 DAG1/AKR1B1/TMEM150C/DDB1/EGFR/GJA1/PARP1/EFHD1/RPL26/OPN3/NPM1/HSPA5/NMT1/DHX36/PLEC/SLC9A1/MDM2/RHOB/NIPBL/NET1/ADIRF/HRAS/CDKN1A/ENG/RAC1/CYBA 26 GO:0104004 cellular response to environmental stimulus 26/725 331/18722 0.000534061988312062 0.00946559517046798 DAG1/AKR1B1/TMEM150C/DDB1/EGFR/GJA1/PARP1/EFHD1/RPL26/OPN3/NPM1/HSPA5/NMT1/DHX36/PLEC/SLC9A1/MDM2/RHOB/NIPBL/NET1/ADIRF/HRAS/CDKN1A/ENG/RAC1/CYBA 26 GO:0007623 circadian rhythm 19/725 210/18722 0.000543953257388798 0.00960731380384605 LGR4/JUN/JUND/PRKDC/DDB1/MAGED1/EGFR/ADRB1/ZFHX3/OPN3/SLC6A4/MYCBP2/PHLPP1/GNAQ/CLDN4/KDM5A/HUWE1/NCOA2/USP9X 19 GO:0010466 negative regulation of peptidase activity 22/725 262/18722 0.000577833893303376 0.0101702777956764 GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/LRP1/APP/DHCR24/TFPI2/CRIM1/GPC3/ROCK1/HERPUD1/MDM2/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2 22 GO:0034975 protein folding in endoplasmic reticulum 4/725 11/18722 0.000591858656784946 0.0103027870706006 HSP90B1/HSPA5/P4HB/ERO1A 4 GO:0035581 sequestering of extracellular ligand from receptor 4/725 11/18722 0.000591858656784946 0.0103027870706006 FBN1/FBN2/CD46/LTBP1 4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 4/725 11/18722 0.000591858656784946 0.0103027870706006 HSPA5/CEBPB/DDIT3/ATF3 4 GO:0070302 regulation of stress-activated protein kinase signaling cascade 18/725 195/18722 0.000594943164712916 0.0103027870706006 MAP3K4/APP/DUSP1/EGFR/GADD45B/PDCD4/EZR/PHLPP1/ARL6IP5/DLG1/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/PPIA/SDCBP 18 GO:0032835 glomerulus development 9/725 62/18722 0.000601311522179078 0.0103027870706006 BASP1/LGR4/ENPEP/BMP7/BCL2/IQGAP1/MTSS1/HES1/CFLAR 9 GO:0072331 signal transduction by p53 class mediator 16/725 163/18722 0.000604888833629076 0.0103027870706006 MIF/PMAIP1/DDX5/SOX4/PTTG1IP/RPL26/NPM1/ATRX/USP10/BCL2/MDM2/RPS20/HINT1/CDKN1A/EIF5A/SGK1 16 GO:0007569 cell aging 14/725 132/18722 0.000605067309247749 0.0103027870706006 MIF/PRKDC/TBX3/PDCD4/NPM1/YPEL3/BCL2/HRAS/NEK6/CDKN1A/SERPINE1/ARG2/B2M/YBX1 14 GO:0035264 multicellular organism growth 14/725 132/18722 0.000605067309247749 0.0103027870706006 IGF2/APP/ADRB1/EZR/ATRX/BCL2/AFG3L2/LGMN/ARID5B/PLEC/GHR/NIPBL/GDF15/ZFX 14 GO:0006941 striated muscle contraction 17/725 179/18722 0.000605219718661983 0.0103027870706006 ALDOA/AKAP9/CAV1/GJA1/GAA/CALM1/PDE4B/HOMER1/DSG2/GJA5/SLC9A1/DLG1/DSC2/C12orf57/SRI/ARG2/GSTO1 17 GO:0048511 rhythmic process 24/725 298/18722 0.000605687620248368 0.0103027870706006 LGR4/JUN/JUND/PRKDC/DDB1/MAGED1/EGFR/ADRB1/DDX5/ZFHX3/OPN3/SLC6A4/MYCBP2/PHLPP1/HSPA5/ADAMTS1/GNAQ/CLDN4/KDM5A/SERPINF1/HUWE1/KDM5B/NCOA2/USP9X 24 GO:0006469 negative regulation of protein kinase activity 19/725 212/18722 0.000611115089879473 0.0103603424434751 CAV1/DUSP1/GADD45B/NR2F2/PDCD4/LRP5/NF1/NPM1/HSPB1/BMP7/PKIB/LATS2/GNAQ/PLEC/CDKN1A/CDKN1C/PIK3CB/PPIA/CBLB 19 GO:0007159 leukocyte cell-cell adhesion 28/725 371/18722 0.000625702392531816 0.0105722847591459 CAV1/ITGB1/IGF2/DLG5/CD46/TFRC/S100A9/HSPD1/ANXA1/PNP/EZR/SOX4/GLI3/IL6ST/RHOA/BMP7/SOCS1/NFAT5/ROCK1/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/B2M/CBLB 28 GO:0043409 negative regulation of MAPK cascade 17/725 180/18722 0.000644874550292842 0.0108600302173901 CAV1/FBLN1/DAG1/SEMA6A/DUSP1/DUSP6/PDCD4/EZR/NF1/BMP7/DUSP9/ASH1L/DLG1/ATF3/TIMP3/PIK3CB/PPIA 17 GO:0042594 response to starvation 18/725 197/18722 0.000671124144683836 0.0112646632099416 JUN/PMAIP1/HSPA8/UPP1/NFE2L2/GLUL/CTSV/HSPA5/TFEB/BCL2/LARP1/HNRNPA1/RALB/CPEB4/CDKN1A/DDIT3/ATF3/MAP1LC3B 18 GO:0031100 animal organ regeneration 10/725 76/18722 0.000675893174133418 0.0112700740121128 RPL19/TGFBR3/EGFR/RPS16/PGF/GLI3/CSNK2B/CEBPB/UPF2/CDKN1A 10 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 10/725 76/18722 0.000675893174133418 0.0112700740121128 MIF/PMAIP1/DDX5/PTTG1IP/RPL26/BCL2/MDM2/HINT1/CDKN1A/EIF5A 10 GO:0051592 response to calcium ion 15/725 149/18722 0.000681096132935637 0.0113021626546019 CAV1/FOS/FUS/JUND/DUSP1/EGFR/FOSB/CALM1/TXNIP/PDCD6/HSPA5/HOMER1/LGMN/IQGAP1/SYT7 15 GO:0061564 axon development 33/725 467/18722 0.000684236598805757 0.0113021626546019 NRP2/ITGB1/RPL24/LRP1/SEMA6D/APP/DAG1/SEMA6A/KIF5B/EPHB4/LAMA5/MACF1/ISL1/GOLGA4/GRN/GLI3/JAM3/MYCBP2/BMP7/COBL/MTR/NREP/B3GNT2/BCL2/AFG3L2/PTPRF/C12orf57/USP9X/SEMA4C/RAB11A/RTN4/S100A6/RAC1 33 GO:0045766 positive regulation of angiogenesis 17/725 181/18722 0.000686736259147244 0.0113021626546019 ITGB1/PKM/ADAM12/ISL1/PGF/NFE2L2/PDCD6/GRN/HSPB1/APELA/RHOB/SASH1/AGO2/HMGB1/SERPINE1/ENG/FLT1 17 GO:1904018 positive regulation of vasculature development 17/725 181/18722 0.000686736259147244 0.0113021626546019 ITGB1/PKM/ADAM12/ISL1/PGF/NFE2L2/PDCD6/GRN/HSPB1/APELA/RHOB/SASH1/AGO2/HMGB1/SERPINE1/ENG/FLT1 17 GO:0046661 male sex differentiation 16/725 165/18722 0.000691194177460243 0.011338716134453 ADGRG1/LGR4/LRP2/DHCR24/SF1/TBX3/FSTL3/NASP/CTSV/ATRX/BCL2/ARID5B/EIF2S2/KDM5A/INHA/RHOBTB3 16 GO:0062197 cellular response to chemical stress 26/725 337/18722 0.000698028782450814 0.0114138964459457 CAV1/FOS/JUN/SOD3/AKR1B1/EGFR/DHRS2/ANXA1/MET/PARP1/NFE2L2/EFHD1/HSPB1/BMP7/P4HB/BCL2/ARL6IP5/FUT8/PLEC/HSPA1A/MDM2/RHOB/NET1/DDIT3/CHCHD2/PPIA 26 GO:0006417 regulation of translation 33/725 468/18722 0.000709766325798324 0.0115685064484621 GAPDH/APP/EIF4H/PKM/PRKDC/NEURL1/BTG2/SOX4/RPL10/RPL26/RHOA/NPM1/HSPB1/RPL13A/DHX36/IGF2BP3/ROCK1/PUM1/RPL22/LARP1/TNRC6B/PPP1R15A/QKI/EIF1/CPEB4/PURA/SECISBP2L/AGO2/EIF3H/EIF5A/SERP1/PAIP2/YBX1 33 GO:0032271 regulation of protein polymerization 20/725 232/18722 0.000727617234267665 0.0118214479503295 IQGAP2/AKAP9/KANK1/CLIP1/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/WASF2/HSPA1A/DLG1/ARPC3/PFN1/NUMA1/RASA1/RAC1/ARF1/CAPZB 20 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 6/725 29/18722 0.000731341334378843 0.0118439911308829 MIF/PTTG1IP/RPL26/BCL2/MDM2/EIF5A 6 GO:0032412 regulation of ion transmembrane transporter activity 22/725 267/18722 0.000744069847859755 0.0120117517796213 TCAF1/C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/APP/KIF5B/STOM/CALM1/TMSB4X/ABCB1/PDE4B/HOMER1/GOPC/SLC9A1/DLG1/VAMP2/SRI/GLRX/GSTO1 22 GO:0021675 nerve development 10/725 77/18722 0.000750340727019708 0.0120745306198822 NRP2/RPL24/DAG1/ISL1/GLI3/CTSV/DICER1/AFG3L2/TFAP2A/HES1 10 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 9/725 64/18722 0.000762147246601853 0.0121864820527286 DYNLL1/LRP1/KIF5B/LRP5/HMGN3/MPC2/SRI/PHPT1/RAC1 9 GO:0052548 regulation of endopeptidase activity 31/725 432/18722 0.000764918676460097 0.0121864820527286 GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/APP/PMAIP1/S100A9/DHCR24/HSPD1/TFPI2/PDCD6/CRIM1/RHOA/ROCK1/LGMN/HERPUD1/ARL6IP5/MDM2/BIRC6/ASPH/SERPINF1/SERPINH1/SERPINB1/CFLAR/RIPK2/HMGB1/SERPINB2/SERPINE1/TIMP3/TIMP2 31 GO:0060070 canonical Wnt signaling pathway 24/725 303/18722 0.000765736323136348 0.0121864820527286 WLS/CAV1/LGR5/LGR4/TLE4/KANK1/PLPP3/EGFR/ISL1/RPS12/RBPJ/CTNND1/ZNRF3/SOX4/GLI3/LRP5/GPC3/TBL1X/LATS2/GNAQ/TLE1/ATP6AP2/DDIT3/ZNF703 24 GO:0007052 mitotic spindle organization 13/725 120/18722 0.000766914139834369 0.0121864820527286 TACC2/RHOA/DYNC1H1/CLTC/HSPA1A/GPSM2/KPNB1/STAG1/NEK6/NUMA1/RAB11A/CCSAP/DCTN6 13 GO:0051348 negative regulation of transferase activity 22/725 268/18722 0.000781880271862674 0.012358792628205 CAV1/DUSP1/GADD45B/NR2F2/PDCD4/LRP5/NF1/NPM1/HSPB1/BMP7/PKIB/LATS2/GNAQ/PLEC/RPS20/PIP4K2A/CDKN1A/CDKN1C/PHPT1/PIK3CB/PPIA/CBLB 22 GO:0044409 entry into host 15/725 151/18722 0.000782634135658672 0.012358792628205 CAV1/ITGB1/CD46/TFRC/DAG1/ITGAV/EGFR/CTSL/P4HB/SLC52A1/HSPA1A/CD55/UVRAG/LY6E/RPSA 15 GO:0003015 heart process 21/725 251/18722 0.00079954416465588 0.0125866129523002 ATP2B1/CYP2J2/AKAP9/CAV1/ADRB1/GJA1/GAA/CALM1/ISL1/PDE4B/DSG2/GJA5/APELA/SLC9A1/DLG1/MDM2/DSC2/CDC42/HOPX/SRI/GSTO1 21 GO:0030038 contractile actin filament bundle assembly 12/725 106/18722 0.000817264460984571 0.0127414796217524 MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/CDC42/TACSTD2/RAC1 12 GO:0043149 stress fiber assembly 12/725 106/18722 0.000817264460984571 0.0127414796217524 MET/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/CDC42/TACSTD2/RAC1 12 GO:0090263 positive regulation of canonical Wnt signaling pathway 12/725 106/18722 0.000817264460984571 0.0127414796217524 WLS/CAV1/LGR5/LGR4/KANK1/EGFR/RPS12/RBPJ/SOX4/GPC3/TBL1X/ATP6AP2 12 GO:0048025 negative regulation of mRNA splicing, via spliceosome 5/725 20/18722 0.000819889748824564 0.0127414796217524 SAP18/NPM1/SRSF9/SRSF7/SRSF6 5 GO:0007051 spindle organization 17/725 184/18722 0.000826567728631774 0.0127414796217524 TACC2/EZR/RHOA/DYNC1H1/ATRX/CLTC/HSPA1A/DLG1/GPSM2/KPNB1/STAG1/UVRAG/NEK6/NUMA1/RAB11A/CCSAP/DCTN6 17 GO:0001704 formation of primary germ layer 13/725 121/18722 0.000829490683601953 0.0127414796217524 WLS/ITGB1/ITGB4/ITGAV/LAMB1/DUSP1/GJA1/BMP7/APELA/COL4A2/RTF1/TXNRD1/SETD2 13 GO:0003206 cardiac chamber morphogenesis 13/725 121/18722 0.000829490683601953 0.0127414796217524 NRP2/LRP2/TGFBR3/TBX3/ISL1/RBPJ/SOX4/BMP7/ADAMTS1/MDM2/LY6E/HES1/ENG 13 GO:0045931 positive regulation of mitotic cell cycle 13/725 121/18722 0.000829490683601953 0.0127414796217524 BRD4/APP/EGFR/ANXA1/PBX1/ADAMTS1/PPP1R10/LGMN/PKN2/USP22/MDM2/HES1/RAB11A 13 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 4/725 12/18722 0.000860681143998035 0.0131014796364145 HSPA5/SEC62/SEC61B/SEC61G 4 GO:0098911 regulation of ventricular cardiac muscle cell action potential 4/725 12/18722 0.000860681143998035 0.0131014796364145 CAV1/DSG2/DLG1/DSC2 4 GO:0098974 postsynaptic actin cytoskeleton organization 4/725 12/18722 0.000860681143998035 0.0131014796364145 PPP1R9A/ACTG1/WASF2/ARF1 4 GO:0030900 forebrain development 28/725 379/18722 0.000869607389353658 0.0131191662399812 NRP2/LRP1/ADGRG1/LRP2/APP/KIF5B/LAMB1/TACC2/CDH1/TBX3/NR2F2/BTG2/ISL1/RBPJ/GLI3/RHOA/NF1/ATRX/HOOK3/TRA2B/GNG12/BTBD3/HSD3B1/C12orf57/HES1/SETD2/RTN4/B2M 28 GO:0050878 regulation of body fluid levels 28/725 379/18722 0.000869607389353658 0.0131191662399812 F5/CAV1/FBLN1/AKR1B1/EGFR/GJA1/KCNN4/MET/LMAN1/NEURL1/TFPI2/GNA12/NFE2L2/IL6ST/HSPB1/ACTG1/GJA5/GNAQ/CLDN4/PLEC/C1QTNF1/AK3/CLIC1/SERPINB2/SERPINE1/PIK3CB/PPIA/CYBA 28 GO:0051346 negative regulation of hydrolase activity 28/725 379/18722 0.000869607389353658 0.0131191662399812 GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/LRP1/APP/DHCR24/ANXA1/TFPI2/CRIM1/GPC3/ROCK1/HERPUD1/BOD1L1/MDM2/KDM5A/BIRC6/PPP1R15A/SERPINF1/HRAS/AMOT/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2 28 GO:0007266 Rho protein signal transduction 14/725 137/18722 0.000876483893995312 0.0131446652623143 ITGB1/ADGRG1/KANK1/HACD3/MET/GNA12/EPS8L1/RHOA/ROCK1/CFL1/RHOB/NET1/CDC42/RAC1 14 GO:0050671 positive regulation of lymphocyte proliferation 14/725 137/18722 0.000876483893995312 0.0131446652623143 IGF2/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1 14 GO:0097305 response to alcohol 21/725 253/18722 0.000885067234954056 0.0132342354394753 ATP2B1/FOS/DAG1/TGFBR3/CDH1/FOSB/EEF1B2/CALM1/PARP1/RPL15/DNMT3A/RHOA/RPL10A/LARP1/MDM2/CAT/HSD3B1/RPL27/CDKN1A/FDX1/CYBA 21 GO:0007229 integrin-mediated signaling pathway 12/725 107/18722 0.000888801491112206 0.0132509845836699 ITGB1/ITGB4/CD63/ITGAV/PLPP3/ITGA6/DST/LAMA5/PTPRA/ADAMTS1/FUT8/CDC42 12 GO:0032388 positive regulation of intracellular transport 18/725 202/18722 0.000899180511484872 0.0133664105944775 TCAF1/KIF5B/CDH1/STOM/EZR/GLI3/DYNC1H1/OAZ1/NMT1/B3GAT3/MDM2/HUWE1/CDC42/HRAS/NUMA1/VAMP2/UBE2D3/ARF1 18 GO:0006446 regulation of translational initiation 10/725 79/18722 0.000919536593031071 0.013629037982674 EIF4H/NPM1/HSPB1/RPL13A/LARP1/PPP1R15A/EIF1/AGO2/EIF3H/PAIP2 10 GO:1901796 regulation of signal transduction by p53 class mediator 11/725 93/18722 0.000924124490572764 0.0136571050807969 MIF/PMAIP1/DDX5/PTTG1IP/RPL26/NPM1/BCL2/MDM2/RPS20/EIF5A/SGK1 11 GO:0032946 positive regulation of mononuclear cell proliferation 14/725 138/18722 0.000941556357694951 0.0138742708638247 IGF2/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1 14 GO:0019318 hexose metabolic process 20/725 237/18722 0.000948373395331379 0.0138811495366144 GAPDH/ALDOA/TPI1/IGF2/PMAIP1/AKR1B1/DDB1/GAA/PHLDA2/LRP5/ENO1/SLC35B4/FUT8/RANBP2/C1QTNF1/NCOA2/HMGB1/SERP1/PGM2/ATF3 20 GO:0033673 negative regulation of kinase activity 20/725 237/18722 0.000948373395331379 0.0138811495366144 CAV1/DUSP1/GADD45B/NR2F2/PDCD4/LRP5/NF1/NPM1/HSPB1/BMP7/PKIB/LATS2/GNAQ/PLEC/PIP4K2A/CDKN1A/CDKN1C/PIK3CB/PPIA/CBLB 20 GO:0048872 homeostasis of number of cells 22/725 272/18722 0.000950238486724245 0.0138811495366144 ADGRG1/LGR4/PMAIP1/TGFBR3/PRKDC/RPS6/ANXA1/SOX4/RPS19/JAM3/PDE4B/BCL2/HSPA1A/UFL1/UBA5/RCOR1/FAM210B/INHA/ZFX/HMGB1/PIK3CB/B2M 22 GO:0008360 regulation of cell shape 15/725 154/18722 0.000958865317489907 0.0139669203860814 ALDOA/MYH10/DAG1/ARHGAP18/ANXA1/EZR/RHOA/DLG1/RHOB/MYL12B/BRWD1/RHOBTB3/EPB41L3/RASA1/RAC1 15 GO:0032535 regulation of cellular component size 28/725 382/18722 0.000980467657308483 0.0142406606157499 IQGAP2/LRP1/KANK1/SEMA6D/SEMA6A/KCNN4/ARHGAP18/MACF1/TRIOBP/TMSB4X/GOLGA4/EZR/RHOA/PPP1R9A/NPM1/HP1BP3/WASF2/DLG1/ARPC3/PFN1/PPP1R15A/RASA1/SEMA4C/RAB11A/RTN4/RAC1/ARF1/CAPZB 28 GO:0045056 transcytosis 5/725 21/18722 0.00104209916692981 0.0150576342433497 LRP1/LRP2/LRPAP1/CLTC/RAB11A 5 GO:0097237 cellular response to toxic substance 13/725 124/18722 0.00104349507672535 0.0150576342433497 GPX3/PRDX6/SOD3/S100A9/NFE2L2/PPP1R9A/BMP7/GPX4/CAT/ADH5/TXNRD1/GLRX/GSTO1 13 GO:0014912 negative regulation of smooth muscle cell migration 7/725 42/18722 0.0010486655348839 0.0150576342433497 LRP1/SEMA6D/IGFBP3/GNA12/NFE2L2/RHOA/SERPINE1 7 GO:0051403 stress-activated MAPK cascade 20/725 239/18722 0.00105156885424064 0.0150576342433497 MAP3K4/APP/HACD3/DUSP1/EGFR/GADD45B/PDCD4/EZR/PHLPP1/DUSP9/ARL6IP5/DLG1/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/PPIA/SDCBP 20 GO:0072593 reactive oxygen species metabolic process 20/725 239/18722 0.00105156885424064 0.0150576342433497 GPX3/PRDX6/SOD3/PMAIP1/HSPD1/EGFR/NFE2L2/RHOA/BMP7/STK17A/BCL2/CAT/CDKN1A/TFAP2A/CFLAR/ARF4/RFK/RAC1/ARG2/CYBA 20 GO:0071480 cellular response to gamma radiation 6/725 31/18722 0.00106137162402306 0.0151551908793603 RPL26/HSPA5/MDM2/HRAS/CDKN1A/CYBA 6 GO:0014032 neural crest cell development 10/725 81/18722 0.00111881511914638 0.0159305444914411 NRP2/SEMA6D/SEMA6A/LAMA5/ISL1/PDCD6/BMP7/RDH10/HES1/SEMA4C 10 GO:1903829 positive regulation of cellular protein localization 22/725 276/18722 0.00114898822862669 0.0163143454647302 TCAF1/ITGB1/LRP1/TFRC/KIF5B/EGFR/CDH1/STOM/PARP1/EZR/GLI3/NPM1/NMT1/DLG1/GPSM2/IQGAP1/HUWE1/HRAS/NUMA1/RAB11A/RTN4/UBE2D3 22 GO:0016049 cell growth 33/725 482/18722 0.00116599233668216 0.0164852007797632 NRP2/ITGB1/LRP1/SEMA6D/APP/SEMA6A/S100A9/EGFR/GJA1/MACF1/GOLGA4/RHOA/ENO1/NPM1/COBL/SPAG9/BCL2/CHPT1/HSPA1A/SLC9A1/IQGAP1/NET1/SERTAD2/CDC42/CDKN1A/EPB41L3/USP9X/SEMA4C/RAB11A/RTN4/SGK1/SDCBP/CYBA 33 GO:0051017 actin filament bundle assembly 15/725 157/18722 0.00116752556321464 0.0164852007797632 MET/EZR/HSP90B1/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/MTSS1/CDC42/TACSTD2/RAC1 15 GO:0098900 regulation of action potential 8/725 55/18722 0.00118335361877233 0.0166622763709914 AKAP9/CAV1/CALM1/DSG2/GJA5/SLC9A1/DLG1/DSC2 8 GO:0006458 'de novo' protein folding 7/725 43/18722 0.00121135785556409 0.0169156280161278 HSPD1/HSPA8/HSPA5/HSPA1A/ERO1A/DNAJB14/DNAJB4 7 GO:0010171 body morphogenesis 7/725 43/18722 0.00121135785556409 0.0169156280161278 DAG1/ANKRD11/GPC3/ARID5B/ATP6AP2/NIPBL/PHLDB2 7 GO:0061383 trabecula morphogenesis 7/725 43/18722 0.00121135785556409 0.0169156280161278 FBN2/TGFBR3/RBPJ/RHOA/BMP7/ADAMTS1/ENG 7 GO:2001252 positive regulation of chromosome organization 10/725 82/18722 0.00123093204534048 0.0171417432357991 MAP3K4/MPHOSPH8/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/DNMT1/NUMA1 10 GO:0050670 regulation of lymphocyte proliferation 19/725 225/18722 0.0012476995981219 0.0173135313313219 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 19 GO:0050821 protein stabilization 17/725 191/18722 0.00125009912552058 0.0173135313313219 GAPDH/AAK1/PLPP3/HSPD1/USP27X/CTNND1/GRN/SOX4/NPM1/TRIM44/TBL1X/ZSWIM7/GNAQ/HSPA1A/PFN1/USP9X/RTN4 17 GO:0051497 negative regulation of stress fiber assembly 6/725 32/18722 0.00126406445272526 0.0173646143925864 MET/PPP1R9A/WASF2/PHLDB2/PFN1/TACSTD2 6 GO:0060317 cardiac epithelial to mesenchymal transition 6/725 32/18722 0.00126406445272526 0.0173646143925864 TGFBR3/TBX3/PDCD4/RBPJ/RTN4/ENG 6 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 6/725 32/18722 0.00126406445272526 0.0173646143925864 PMAIP1/HERPUD1/HSPA1A/GRINA/ERP29/DDIT3 6 GO:1990778 protein localization to cell periphery 25/725 333/18722 0.00128719001472806 0.0175482823897264 CAV1/ITGB1/LRP1/DAG1/KRT18/KIF5B/EGFR/CDH1/LAMA5/MACF1/GOLGA4/EZR/ROCK1/CLTC/ARL6IP5/TMEM150A/GOPC/DLG1/GPSM2/HRAS/EPB41L3/NUMA1/VAMP2/RAB11A/TMBIM1 25 GO:0031331 positive regulation of cellular catabolic process 30/725 427/18722 0.00128782028979645 0.0175482823897264 CAV1/LRP1/LRP2/APP/CTSC/KCNQ1OT1/BTG2/NFE2L2/EZR/PTTG1IP/BNIP3L/DHX36/TFEB/ROCK1/PUM1/LARP1/HERPUD1/HSPB8/HSPA1A/UFL1/MDM2/TNRC6B/RALB/DDA1/UVRAG/PIP4K2A/AGO2/RIPK2/HMGB1/PIK3CB 30 GO:0043254 regulation of protein-containing complex assembly 30/725 427/18722 0.00128782028979645 0.0175482823897264 IQGAP2/AKAP9/KANK1/TFRC/CLIP1/HSPA8/ARHGAP18/MET/ISL1/PARP1/TRIOBP/TMSB4X/RHOA/PPP1R9A/JAM3/RPL13A/HSPA5/WASF2/HSPA1A/DLG1/ARPC3/PFN1/RALB/CDC42/NUMA1/RASA1/HMGB1/RAC1/ARF1/CAPZB 30 GO:1905475 regulation of protein localization to membrane 16/725 175/18722 0.00129748169550548 0.0176325327466951 TCAF1/ITGB1/LRP1/DAG1/KIF5B/EGFR/STOM/EZR/GPC3/NMT1/CLTC/GOPC/DLG1/HRAS/RAB11A/TMBIM1 16 GO:0032727 positive regulation of interferon-alpha production 5/725 22/18722 0.00130602496670132 0.017701177957778 HSPD1/DHX36/SETD2/RIPK2/HMGB1 5 GO:0070252 actin-mediated cell contraction 11/725 97/18722 0.00131187339482494 0.0177330299689803 AKAP9/CAV1/GJA1/PDE4B/MYL6/DSG2/GJA5/SLC9A1/DLG1/DSC2/SRI 11 GO:0045669 positive regulation of osteoblast differentiation 9/725 69/18722 0.0013212733266111 0.0177653434816756 FBN2/JUND/GLI3/IL6ST/LRP5/BMP7/SUCO/CEBPB/CLIC1 9 GO:1904377 positive regulation of protein localization to cell periphery 9/725 69/18722 0.0013212733266111 0.0177653434816756 ITGB1/LRP1/KIF5B/EGFR/EZR/DLG1/GPSM2/NUMA1/RAB11A 9 GO:0031529 ruffle organization 8/725 56/18722 0.00133457357487168 0.0178967022513876 CAV1/KANK1/EPS8L1/COBL/PFN1/HRAS/TACSTD2/RAC1 8 GO:0048678 response to axon injury 10/725 83/18722 0.00135204077010853 0.0180830993764648 LRP1/DAG1/ISL1/GRN/JAM3/MTR/NREP/BCL2/PTPRF/ARF4 10 GO:0010720 positive regulation of cell development 23/725 298/18722 0.00137840129260521 0.018387147768989 SPINT1/LRP1/CUX1/LRP2/DAG1/PRKDC/EGFR/NEURL1/MACF1/TRIOBP/GOLGA4/GLI3/IL6ST/P4HB/DHX36/DICER1/BCL2/UFL1/SERPINF1/CDC42/HES1/RAB11A/RAC1 23 GO:0032944 regulation of mononuclear cell proliferation 19/725 227/18722 0.00138383334383867 0.0184111580575282 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 19 GO:0098656 anion transmembrane transport 20/725 245/18722 0.00142084490636459 0.0188540911789584 SLC26A2/TCAF1/ITGB1/LRP2/GJA1/GABRE/SLC6A8/SLC16A12/SLC13A4/ABCB1/SLC35B4/ARL6IP5/SLC38A9/GOPC/SLC9A1/MPC2/SLC20A1/MFSD12/SLC16A3/SLC7A5 20 GO:0061337 cardiac conduction 11/725 98/18722 0.00142724184943214 0.0188895272448342 ATP2B1/AKAP9/CAV1/GJA1/CALM1/ISL1/DSG2/GJA5/SLC9A1/DSC2/SRI 11 GO:0030100 regulation of endocytosis 18/725 211/18722 0.00147802126543589 0.0195106505064962 CAV1/LRP1/AAK1/CD63/ITGAV/CALM1/LRPAP1/GPC3/MIB1/ROCK1/APELA/CDC42/SERPINE1/RAC1/ARF1/PIK3CB/SDCBP/B2M 18 GO:0003007 heart morphogenesis 20/725 246/18722 0.00149204680552226 0.0195319995352182 NRP2/LRP2/TGFBR3/EPHB4/TBX3/GAA/ISL1/PDCD4/RBPJ/SOX4/BMP7/ADAMTS1/MIB1/GJA5/MDM2/NIPBL/LY6E/HES1/RTN4/ENG 20 GO:0031668 cellular response to extracellular stimulus 20/725 246/18722 0.00149204680552226 0.0195319995352182 ATP2B1/FOS/JUN/PMAIP1/HSPA8/UPP1/NFE2L2/GLUL/CTSV/HSPA5/TFEB/BCL2/PLEC/HNRNPA1/MDM2/RALB/CPEB4/CDKN1A/ATF3/MAP1LC3B 20 GO:0031116 positive regulation of microtubule polymerization 6/725 33/18722 0.00149505145386953 0.0195319995352182 AKAP9/CLIP1/MET/HSPA1A/NUMA1/RAC1 6 GO:0046685 response to arsenic-containing substance 6/725 33/18722 0.00149505145386953 0.0195319995352182 DHX36/HNRNPA1/SERPINF1/CDKN1A/ATF3/GSTO1 6 GO:0061572 actin filament bundle organization 15/725 161/18722 0.0015041125692354 0.0195998627595225 MET/EZR/HSP90B1/RHOA/PPP1R9A/ACTG1/ROCK1/WASF2/SLC9A1/PHLDB2/PFN1/MTSS1/CDC42/TACSTD2/RAC1 15 GO:0046660 female sex differentiation 12/725 114/18722 0.00155007269861617 0.0201469705366291 LRP2/TBX3/NR2F2/IDH1/HSPA5/ADAMTS1/BCL2/CEBPB/ARID5B/INHA/ZFX/CYP19A1 12 GO:0043523 regulation of neuron apoptotic process 18/725 212/18722 0.00155845585904422 0.0202041246790157 LRP1/JUN/HSPD1/BTG2/ISL1/PARP1/GRN/RHOA/NF1/BCL2/LGMN/CEBPB/CDC42/CPEB4/HRAS/TFAP2A/RASA1/DDIT3 18 GO:0030073 insulin secretion 17/725 195/18722 0.0015658784711565 0.0202485662507457 DYNLL1/LRP1/KIF5B/GJA1/ANXA1/ISL1/SOX4/LRP5/GLUL/CAMK2G/SYT7/HMGN3/MPC2/SRI/SERP1/PHPT1/RAC1 17 GO:0030198 extracellular matrix organization 23/725 301/18722 0.00157140737723728 0.0202683562219231 COL14A1/ADAMTS6/CAV1/ITGB1/FBLN1/SPINT1/ADAMTSL4/LRP1/APP/DAG1/SMOC1/CCDC80/LAMC1/LAMB1/NF1/CTSV/ADAMTS1/COL4A2/PHLDB2/ERO1A/SERPINH1/CFLAR/ENG 23 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/725 45/18722 0.00159558595787822 0.020476013216417 PARP1/NFE2L2/HSPB1/P4HB/BCL2/ARL6IP5/PPIA 7 GO:0035272 exocrine system development 7/725 45/18722 0.00159558595787822 0.020476013216417 WLS/IGF2/DAG1/LAMA5/BMP7/TFCP2L1/CDC42 7 GO:0009416 response to light stimulus 24/725 320/18722 0.00161522464866643 0.0205780005986164 ITGB1/FOS/MAP3K4/APP/JUND/DUSP1/DDB1/EGFR/PARP1/RPL26/OPN3/NF1/NPM1/NMT1/DHX36/GNAQ/BCL2/MDM2/CAT/DYNLRB1/CDS1/CDKN1A/RDH13/UBE2A 24 GO:0030325 adrenal gland development 5/725 23/18722 0.00161618090656352 0.0205780005986164 FSTL3/PBX1/NF1/ARID5B/LY6E 5 GO:0042026 protein refolding 5/725 23/18722 0.00161618090656352 0.0205780005986164 HSPD1/HSPA8/HSPA5/HSPA1A/B2M 5 GO:0003281 ventricular septum development 9/725 71/18722 0.00162143450343553 0.0205780005986164 LRP2/TGFBR3/TBX3/RBPJ/SOX4/GJA5/MDM2/TRIP11/HES1 9 GO:0007043 cell-cell junction assembly 14/725 146/18722 0.00162383117763791 0.0205780005986164 CAV1/DLG5/GJA1/CTNND1/RHOA/JAM3/ACTG1/ROCK1/GJA5/CLDN4/PKN2/DLG1/EPB41L3/ZNF703 14 GO:0099188 postsynaptic cytoskeleton organization 4/725 14/18722 0.00163603686770873 0.0206809747691161 PPP1R9A/ACTG1/WASF2/ARF1 4 GO:0043062 extracellular structure organization 23/725 302/18722 0.00164068247493634 0.0206881081230157 COL14A1/ADAMTS6/CAV1/ITGB1/FBLN1/SPINT1/ADAMTSL4/LRP1/APP/DAG1/SMOC1/CCDC80/LAMC1/LAMB1/NF1/CTSV/ADAMTS1/COL4A2/PHLDB2/ERO1A/SERPINH1/CFLAR/ENG 23 GO:0008380 RNA splicing 30/725 434/18722 0.00165438131067509 0.0207086345078722 PRDX6/SON/RPS13/FUS/RBM39/HSPA8/SF1/DDX5/SCAF11/ZC3H13/SAP18/SRRM2/NPM1/RBM25/RPS26/SRSF9/TRA2B/SRSF7/HSPA1A/HNRNPA1/PPIG/PNN/DDX17/QKI/SRSF6/PRPF38B/POLR2A/SNU13/SNRPD2/YBX1 30 GO:0006006 glucose metabolic process 17/725 196/18722 0.00165456637910598 0.0207086345078722 GAPDH/TPI1/IGF2/PMAIP1/DDB1/GAA/PHLDA2/LRP5/ENO1/SLC35B4/RANBP2/C1QTNF1/NCOA2/HMGB1/SERP1/PGM2/ATF3 17 GO:0045664 regulation of neuron differentiation 17/725 196/18722 0.00165456637910598 0.0207086345078722 APP/ISL1/ZFHX3/GLI3/PBX1/RHOA/SLC6A4/BMP7/HMG20B/SPAG9/MIB1/NREP/ROCK1/BCL2/HES1/TIMP2/B2M 17 GO:0043666 regulation of phosphoprotein phosphatase activity 8/725 58/18722 0.0016829304603497 0.0210117598608685 SLC39A10/CALM1/HSP90B1/CSNK2B/ROCK1/BOD1L1/PPP6R2/PPP1R15A 8 GO:0007162 negative regulation of cell adhesion 23/725 303/18722 0.00171255305169134 0.0213290698256103 FBLN1/LRP1/DLG5/KANK1/SEMA6A/DUSP1/CDH1/ANXA1/GLI3/RHOA/JAM3/SOCS1/CEBPB/DLG1/PHLDB2/C1QTNF1/RASA1/TACSTD2/HMGB1/SERPINE1/ZNF703/ARG2/CBLB 23 GO:0046683 response to organophosphorus 13/725 131/18722 0.00172700309756238 0.0214202586223989 LDHA/AKAP9/FOS/APP/JUN/HSPD1/DUSP1/FOSB/EZR/HSP90B1/SLC6A4/HSPA5/FDX1 13 GO:0000082 G1/S transition of mitotic cell cycle 18/725 214/18722 0.001730473019756 0.0214202586223989 ITGB1/BRD4/PRKDC/EGFR/RPS6/CTDSPL/ANXA1/NASP/SOX4/RPL26/ADAMTS1/BRD7/LATS2/BCL2/DLG1/MDM2/CDKN1A/BACH1 18 GO:0016331 morphogenesis of embryonic epithelium 14/725 147/18722 0.0017325519895805 0.0214202586223989 SPINT1/LRP2/LAMA5/SOX4/BMP7/COBL/MIB1/IRX2/RDH10/PFN1/BRD2/TFAP2A/SETD2/SEMA4C 14 GO:0051085 chaperone cofactor-dependent protein refolding 6/725 34/18722 0.00175681276791324 0.02166735747093 HSPA8/HSPA5/HSPA1A/ERO1A/DNAJB14/DNAJB4 6 GO:0045229 external encapsulating structure organization 23/725 304/18722 0.00178709685993507 0.0219791127753411 COL14A1/ADAMTS6/CAV1/ITGB1/FBLN1/SPINT1/ADAMTSL4/LRP1/APP/DAG1/SMOC1/CCDC80/LAMC1/LAMB1/NF1/CTSV/ADAMTS1/COL4A2/PHLDB2/ERO1A/SERPINH1/CFLAR/ENG 23 GO:0071479 cellular response to ionizing radiation 9/725 72/18722 0.0017907621969256 0.0219791127753411 RPL26/HSPA5/MDM2/RHOB/NIPBL/NET1/HRAS/CDKN1A/CYBA 9 GO:1990748 cellular detoxification 12/725 116/18722 0.00180004037553387 0.0220396247912588 GPX3/PRDX6/SOD3/S100A9/NFE2L2/BMP7/GPX4/CAT/ADH5/TXNRD1/GLRX/GSTO1 12 GO:0031669 cellular response to nutrient levels 18/725 215/18722 0.00182232165856434 0.0222278273002103 ATP2B1/JUN/PMAIP1/HSPA8/UPP1/NFE2L2/GLUL/CTSV/HSPA5/TFEB/BCL2/HNRNPA1/MDM2/RALB/CPEB4/CDKN1A/ATF3/MAP1LC3B 18 GO:0098869 cellular oxidant detoxification 11/725 101/18722 0.00182418152631436 0.0222278273002103 GPX3/PRDX6/SOD3/S100A9/NFE2L2/BMP7/GPX4/CAT/TXNRD1/GLRX/GSTO1 11 GO:0010212 response to ionizing radiation 14/725 148/18722 0.00184725507787835 0.0224293246778632 PRKDC/ANXA1/PARP1/RPL26/DNMT3A/HSPA5/BCL2/MDM2/RHOB/NIPBL/NET1/HRAS/CDKN1A/CYBA 14 GO:0045667 regulation of osteoblast differentiation 13/725 132/18722 0.00184956751141188 0.0224293246778632 FBN2/SMOC1/JUND/DDX5/CRIM1/GLI3/IL6ST/LRP5/BMP7/SUCO/ESRRA/CEBPB/CLIC1 13 GO:0050796 regulation of insulin secretion 15/725 165/18722 0.0019184231140467 0.023208798962059 DYNLL1/LRP1/KIF5B/GJA1/ISL1/SOX4/LRP5/GLUL/SYT7/HMGN3/MPC2/SRI/SERP1/PHPT1/RAC1 15 GO:0046651 lymphocyte proliferation 22/725 288/18722 0.00197320104711921 0.0237670182531965 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/HSPD1/RPS6/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/PURA/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 22 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 9/725 73/18722 0.00197394253000508 0.0237670182531965 DYNLL1/LRP1/KIF5B/LRP5/HMGN3/MPC2/SRI/PHPT1/RAC1 9 GO:0010951 negative regulation of endopeptidase activity 20/725 252/18722 0.00198620779398696 0.0238016248409454 GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/APP/DHCR24/TFPI2/CRIM1/ROCK1/HERPUD1/MDM2/BIRC6/SERPINF1/SERPINH1/SERPINB1/SERPINB2/SERPINE1/TIMP3/TIMP2 20 GO:0090257 regulation of muscle system process 20/725 252/18722 0.00198620779398696 0.0238016248409454 ATP2B1/AKAP9/CAV1/DAG1/CALM1/PARP1/IL6ST/RHOA/ENO1/PDE4B/DSG2/ROCK1/GJA5/CAMK2G/SLC9A1/DLG1/DSC2/C12orf57/SRI/GSTO1 20 GO:0007596 blood coagulation 18/725 217/18722 0.00201838766051073 0.0241302053092663 F5/CAV1/FBLN1/LMAN1/TFPI2/GNA12/NFE2L2/IL6ST/HSPB1/ACTG1/GNAQ/C1QTNF1/AK3/CLIC1/SERPINB2/SERPINE1/PIK3CB/PPIA 18 GO:0032232 negative regulation of actin filament bundle assembly 6/725 35/18722 0.00205189799274819 0.0243584799185962 MET/PPP1R9A/WASF2/PHLDB2/PFN1/TACSTD2 6 GO:0060236 regulation of mitotic spindle organization 6/725 35/18722 0.00205189799274819 0.0243584799185962 DYNC1H1/CLTC/HSPA1A/GPSM2/NUMA1/CCSAP 6 GO:0097421 liver regeneration 6/725 35/18722 0.00205189799274819 0.0243584799185962 RPL19/EGFR/RPS16/GLI3/CSNK2B/CEBPB 6 GO:0014911 positive regulation of smooth muscle cell migration 7/725 47/18722 0.00206851211919366 0.0244412306111717 LRP1/S100A11/SEMA6D/ADAMTS1/BCL2/MDM2/IQGAP1 7 GO:1900744 regulation of p38MAPK cascade 7/725 47/18722 0.00206851211919366 0.0244412306111717 MAP3K4/DUSP1/GADD45B/EZR/PHLPP1/DLG1/SASH1 7 GO:0022612 gland morphogenesis 12/725 118/18722 0.00208218590995083 0.0245455822733506 CAV1/DAG1/LAMA5/TBX3/GLI3/LRP5/BMP7/BCL2/CEBPB/CDC42/KDM5B/CFLAR 12 GO:0070665 positive regulation of leukocyte proliferation 14/725 150/18722 0.00209561295506918 0.024646547724468 IGF2/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1 14 GO:0042074 cell migration involved in gastrulation 4/725 15/18722 0.00216312100476413 0.024831036981581 LRP5/GPC3/APELA/AMOT 4 GO:0045176 apical protein localization 4/725 15/18722 0.00216312100476413 0.024831036981581 DLG5/JAM3/GOPC/ARF4 4 GO:0098760 response to interleukin-7 4/725 15/18722 0.00216312100476413 0.024831036981581 HSPD1/P4HB/HMGB1/YBX1 4 GO:0098761 cellular response to interleukin-7 4/725 15/18722 0.00216312100476413 0.024831036981581 HSPD1/P4HB/HMGB1/YBX1 4 GO:1900029 positive regulation of ruffle assembly 4/725 15/18722 0.00216312100476413 0.024831036981581 EPS8L1/COBL/PFN1/HRAS 4 GO:2001028 positive regulation of endothelial cell chemotaxis 4/725 15/18722 0.00216312100476413 0.024831036981581 MET/TMSB4X/HSPB1/LGMN 4 GO:0030072 peptide hormone secretion 19/725 236/18722 0.00216350915780766 0.024831036981581 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ANXA1/ISL1/SOX4/LRP5/GLUL/CAMK2G/SYT7/HMGN3/MPC2/SRI/SERP1/RAB1A/PHPT1/RAC1 19 GO:0090068 positive regulation of cell cycle process 19/725 236/18722 0.00216350915780766 0.024831036981581 IGF2/BRD4/APP/EGFR/ANXA1/PBX1/RHOA/LRP5/NPM1/DYNC1H1/ATRX/ADAMTS1/PPP1R10/PKN2/MDM2/GPSM2/CDC42/NUMA1/RAB11A 19 GO:0009952 anterior/posterior pattern specification 17/725 201/18722 0.00216403486489569 0.024831036981581 WLS/BASP1/PRKDC/TBX3/NR2F2/BTG2/RBPJ/GLI3/PBX1/LRP5/GPC3/COBL/BPTF/MIB1/ATP6AP2/HES1/DDIT3 17 GO:0030968 endoplasmic reticulum unfolded protein response 9/725 74/18722 0.00217176961304714 0.024831036981581 NFE2L2/HSPA5/HERPUD1/UFL1/PPP1R15A/ERO1A/DDIT3/SERP1/ATF3 9 GO:0048332 mesoderm morphogenesis 9/725 74/18722 0.00217176961304714 0.024831036981581 WLS/ITGB1/ITGB4/GJA1/TBX3/BMP7/APELA/TXNRD1/SETD2 9 GO:0070972 protein localization to endoplasmic reticulum 9/725 74/18722 0.00217176961304714 0.024831036981581 GJA1/HSPA5/SEC62/HERPUD1/PPP1R15A/RTN4/KDELR2/SEC61B/SEC61G 9 GO:0042692 muscle cell differentiation 27/725 384/18722 0.00217498134145235 0.024831036981581 KRT19/KRT8/ITGB1/IGF2/ADAM12/TBX3/ISL1/PDCD4/RBPJ/HOMER1/SPAG9/ACTG1/BCL2/AFG3L2/PLEC/SLC9A1/MDM2/QKI/HOPX/HES1/DNMT1/SEMA4C/GDF15/CFLAR/ENG/MORF4L2/YBX1 27 GO:2001020 regulation of response to DNA damage stimulus 18/725 219/18722 0.00223190009257919 0.0254161539391403 TPT1/MIF/FUS/PMAIP1/PRKDC/EGFR/DDX5/PARP1/PTTG1IP/RPL26/NPM1/PPP1R10/BCL2/MDM2/DEK/IER3/SETD2/HMGB1 18 GO:0031398 positive regulation of protein ubiquitination 12/725 119/18722 0.00223626053597486 0.0254161539391403 CAV1/ARRDC3/RPS2/PDCD6/PTTG1IP/SKP1/NPM1/MYCBP2/HSPA5/HUWE1/RIPK2/CBLB 12 GO:0032943 mononuclear cell proliferation 22/725 291/18722 0.0022442559008512 0.0254499623297869 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/HSPD1/RPS6/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/PURA/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 22 GO:0001101 response to acid chemical 13/725 135/18722 0.00226105365540194 0.025583216471501 KRT8/AKR1B1/NEURL1/DNMT3A/RHOA/SOCS1/CEBPB/SLC38A9/PLEC/UFL1/CPEB4/DNMT1/CYBA 13 GO:0042149 cellular response to glucose starvation 7/725 48/18722 0.00234225180950798 0.0264429274440889 PMAIP1/UPP1/NFE2L2/HSPA5/BCL2/HNRNPA1/CPEB4 7 GO:0003203 endocardial cushion morphogenesis 6/725 36/18722 0.00238291812473693 0.0265362446035653 TBX3/ISL1/RBPJ/BMP7/MDM2/ENG 6 GO:0008088 axo-dendritic transport 9/725 75/18722 0.00238505937093013 0.0265362446035653 ARMCX3/APP/KIF5B/HSPA8/DST/DYNC1H1/HSPB1/PURA/ARL8B 9 GO:0032469 endoplasmic reticulum calcium ion homeostasis 5/725 25/18722 0.00239368953591951 0.0265362446035653 APP/BCL2/HERPUD1/CCDC47/GRINA 5 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 5/725 25/18722 0.00239368953591951 0.0265362446035653 CAV1/GJA1/CALM1/GJA5/SRI 5 GO:0090169 regulation of spindle assembly 5/725 25/18722 0.00239368953591951 0.0265362446035653 DYNC1H1/HSPA1A/GPSM2/NUMA1/CCSAP 5 GO:1901798 positive regulation of signal transduction by p53 class mediator 5/725 25/18722 0.00239368953591951 0.0265362446035653 PMAIP1/DDX5/RPL26/RPS20/EIF5A 5 GO:1903959 regulation of anion transmembrane transport 5/725 25/18722 0.00239368953591951 0.0265362446035653 TCAF1/ITGB1/ABCB1/ARL6IP5/GOPC 5 GO:0071901 negative regulation of protein serine/threonine kinase activity 12/725 120/18722 0.00239952124665714 0.0265362446035653 CAV1/DUSP1/NR2F2/PDCD4/LRP5/NF1/BMP7/PKIB/LATS2/CDKN1A/CDKN1C/PIK3CB 12 GO:0032869 cellular response to insulin stimulus 17/725 203/18722 0.00240166728367948 0.0265362446035653 ATP2B1/IGF2/KANK1/PKM/PRKDC/PARP1/LPIN2/PTPRA/SOCS1/ESRRA/GHR/SLC9A1/ZNF106/SLC2A8/PIP4K2A/VAMP2/CFLAR 17 GO:0010959 regulation of metal ion transport 28/725 406/18722 0.00240286768061481 0.0265362446035653 ATP2B1/C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/CD63/KIF5B/GJA1/KCNN4/STOM/CALM1/RHOA/PDE4B/HOMER1/BCL2/CAMK2G/SLC9A1/DLG1/VAMP2/SARAF/SRI/ARF1/GLRX/GSTO1/B2M/CYBA 28 GO:0010975 regulation of neuron projection development 30/725 445/18722 0.00241212500657066 0.0265805688224059 TENM3/LRP1/CUX1/KANK1/SEMA6D/SEMA6A/S100A9/ITGA6/MACF1/GOLGA4/NFE2L2/GRN/RHOA/PPP1R9A/BMP7/COBL/HSPA5/DHX36/CFL1/CAMK2G/MDM2/IQGAP1/PTPRF/SERPINF1/MYLIP/SEMA4C/RAB11A/RTN4/CFLAR/B2M 30 GO:0006937 regulation of muscle contraction 15/725 169/18722 0.00242371053551415 0.0266503008774864 ATP2B1/AKAP9/CAV1/CALM1/RHOA/ENO1/PDE4B/DSG2/GJA5/SLC9A1/DLG1/DSC2/C12orf57/SRI/GSTO1 15 GO:0071478 cellular response to radiation 16/725 186/18722 0.00243057944114518 0.0266679809245994 DDB1/PARP1/RPL26/OPN3/NPM1/HSPA5/NMT1/DHX36/MDM2/RHOB/NIPBL/NET1/ADIRF/HRAS/CDKN1A/CYBA 16 GO:0060048 cardiac muscle contraction 13/725 137/18722 0.00257503970559335 0.0281459772494306 AKAP9/CAV1/GJA1/GAA/CALM1/PDE4B/DSG2/GJA5/SLC9A1/DLG1/DSC2/SRI/GSTO1 13 GO:0000302 response to reactive oxygen species 18/725 222/18722 0.00258749761259314 0.0281459772494306 LDHA/FOS/JUN/SOD3/HSPD1/DUSP1/EGFR/ANXA1/MET/TXNIP/NFE2L2/BMP7/TRA2B/BCL2/MDM2/RHOB/CAT/NET1 18 GO:0007599 hemostasis 18/725 222/18722 0.00258749761259314 0.0281459772494306 F5/CAV1/FBLN1/LMAN1/TFPI2/GNA12/NFE2L2/IL6ST/HSPB1/ACTG1/GNAQ/C1QTNF1/AK3/CLIC1/SERPINB2/SERPINE1/PIK3CB/PPIA 18 GO:0050817 coagulation 18/725 222/18722 0.00258749761259314 0.0281459772494306 F5/CAV1/FBLN1/LMAN1/TFPI2/GNA12/NFE2L2/IL6ST/HSPB1/ACTG1/GNAQ/C1QTNF1/AK3/CLIC1/SERPINB2/SERPINE1/PIK3CB/PPIA 18 GO:0045861 negative regulation of proteolysis 25/725 351/18722 0.00262800168017962 0.0284452533724723 GAPDH/SERPINB9/ITIH5/SPINT1/APLP2/LRP1/APP/GLG1/DHCR24/TFPI2/CRIM1/GPC3/ROCK1/HERPUD1/MDM2/BIRC6/SERPINF1/SERPINH1/SERPINB1/EIF3H/SERPINB2/SERPINE1/TIMP3/TIMP2/SDCBP 25 GO:0034332 adherens junction organization 7/725 49/18722 0.00264306852208216 0.0284452533724723 DLG5/CDH1/JAM3/PLEC/MTSS1/CDC42/ZNF703 7 GO:0038084 vascular endothelial growth factor signaling pathway 7/725 49/18722 0.00264306852208216 0.0284452533724723 NRP2/CD63/SEMA6A/PGF/HSPB1/FLT1/PIK3CB 7 GO:0060964 regulation of gene silencing by miRNA 7/725 49/18722 0.00264306852208216 0.0284452533724723 NEAT1/KCNQ1OT1/EGFR/DDX5/PUM1/TNRC6B/AGO2 7 GO:1904752 regulation of vascular associated smooth muscle cell migration 7/725 49/18722 0.00264306852208216 0.0284452533724723 LRP1/GNA12/NFE2L2/RHOA/ADAMTS1/MDM2/IQGAP1 7 GO:0060348 bone development 17/725 205/18722 0.00266069907537678 0.0285530895126251 FBN1/GLG1/GJA1/RPL13/BBX/GLI3/RHOA/LRP5/WASF2/BGN/GHR/TRIP11/PIP4K2A/TFAP2A/SERPINH1/HSD17B1/ENG 17 GO:0022407 regulation of cell-cell adhesion 30/725 448/18722 0.00266435418020747 0.0285530895126251 CAV1/TENM3/IGF2/DLG5/CD46/TFRC/PLPP3/HSPD1/CDH1/ANXA1/FSTL3/PNP/SOX4/GLI3/IL6ST/RHOA/BMP7/SOCS1/NFAT5/CEBPB/DLG1/CD55/C1QTNF1/HES1/RIPK2/HMGB1/ZNF703/ARG2/B2M/CBLB 30 GO:1905477 positive regulation of protein localization to membrane 11/725 106/18722 0.00268243722408828 0.0286862326770116 TCAF1/ITGB1/LRP1/KIF5B/EGFR/STOM/EZR/NMT1/DLG1/HRAS/RAB11A 11 GO:0014033 neural crest cell differentiation 10/725 91/18722 0.00271141235966086 0.0289122131837217 NRP2/SEMA6D/SEMA6A/LAMA5/ISL1/PDCD6/BMP7/RDH10/HES1/SEMA4C 10 GO:0042129 regulation of T cell proliferation 15/725 171/18722 0.00271497602593244 0.0289122131837217 IGF2/DLG5/CD46/TFRC/ANXA1/PNP/IL6ST/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/CBLB 15 GO:0032273 positive regulation of protein polymerization 13/725 138/18722 0.00274492197377478 0.0290075079677277 IQGAP2/AKAP9/CLIP1/MET/RHOA/WASF2/HSPA1A/DLG1/ARPC3/PFN1/NUMA1/RAC1/ARF1 13 GO:0035107 appendage morphogenesis 13/725 138/18722 0.00274492197377478 0.0290075079677277 FBN2/TBX3/SOX4/GLI3/PBX1/LRP5/BMP7/GPC3/ATRX/FRAS1/RDH10/NIPBL/TFAP2A 13 GO:0035108 limb morphogenesis 13/725 138/18722 0.00274492197377478 0.0290075079677277 FBN2/TBX3/SOX4/GLI3/PBX1/LRP5/BMP7/GPC3/ATRX/FRAS1/RDH10/NIPBL/TFAP2A 13 GO:0031112 positive regulation of microtubule polymerization or depolymerization 6/725 37/18722 0.00275253725241212 0.0290075079677277 AKAP9/CLIP1/MET/HSPA1A/NUMA1/RAC1 6 GO:0032570 response to progesterone 6/725 37/18722 0.00275253725241212 0.0290075079677277 CAV1/FOS/FOSB/TXNIP/CLDN4/NCOA2 6 GO:0051258 protein polymerization 22/725 296/18722 0.00276606239306108 0.0290895648764037 IQGAP2/AKAP9/KANK1/CLIP1/ARHGAP18/MET/TRIOBP/TMSB4X/RHOA/PPP1R9A/COBL/WASF2/GPX4/HSPA1A/DLG1/ARPC3/PFN1/NUMA1/RASA1/RAC1/ARF1/CAPZB 22 GO:0097284 hepatocyte apoptotic process 4/725 16/18722 0.00279658276300159 0.0292286144858867 KRT8/KRT18/DNMT3A/CFLAR 4 GO:0099010 modification of postsynaptic structure 4/725 16/18722 0.00279658276300159 0.0292286144858867 MYH10/RHOA/PFN1/CDC42 4 GO:1901163 regulation of trophoblast cell migration 4/725 16/18722 0.00279658276300159 0.0292286144858867 SYDE1/GJA1/APELA/AGO2 4 GO:0031346 positive regulation of cell projection organization 25/725 353/18722 0.00283235725544675 0.0295416027322214 TENM3/LRP1/CUX1/S100A9/ITGA6/NEURL1/MACF1/GOLGA4/NFE2L2/GRN/EPS8L1/PPP1R9A/BMP7/COBL/HSPA5/DHX36/WASF2/IQGAP1/PFN1/SERPINF1/CDC42/HRAS/RAB11A/CFLAR/RAC1 25 GO:2001234 negative regulation of apoptotic signaling pathway 18/725 224/18722 0.00284994274553529 0.0296534537743715 TPT1/MIF/ITGAV/ITGA6/NFE2L2/PTTG1IP/ENO1/HSPB1/BCL2/HERPUD1/HSPA1A/MDM2/BIRC6/GRINA/CFLAR/SERPINE1/TMBIM1/PPIA 18 GO:0090150 establishment of protein localization to membrane 20/725 260/18722 0.00285478110907345 0.0296534537743715 TCAF1/NACA/KRT18/EGFR/STOM/CALM1/MACF1/GOLGA4/HSPA5/SEC62/NMT1/GOPC/CCDC47/SIL1/HRAS/VAMP2/RAB11A/SEC61B/SEC61G/SDCBP 20 GO:0007492 endoderm development 9/725 77/18722 0.00286139552471813 0.0296550619596227 ITGAV/LAMC1/LAMB1/DUSP1/BPTF/APELA/COL4A2/RTF1/SETD2 9 GO:0002790 peptide secretion 19/725 242/18722 0.0028666364885017 0.0296550619596227 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ANXA1/ISL1/SOX4/LRP5/GLUL/CAMK2G/SYT7/HMGN3/MPC2/SRI/SERP1/RAB1A/PHPT1/RAC1 19 GO:0010927 cellular component assembly involved in morphogenesis 11/725 107/18722 0.00288795798515846 0.0297541850137566 KRT19/KRT8/ITGB1/ITGB4/DAG1/ACTG1/DICER1/PLEC/PHLDB2/EPB41L3/CFLAR 11 GO:0031532 actin cytoskeleton reorganization 11/725 107/18722 0.00288795798515846 0.0297541850137566 SYDE1/IQGAP2/ANXA1/NRK/EZR/RHOA/THSD7A/PLEC/CDC42/HRAS/PHPT1 11 GO:0003231 cardiac ventricle development 12/725 123/18722 0.00294847299317048 0.0303160438182174 LRP2/TGFBR3/TBX3/ISL1/RBPJ/SOX4/GJA5/MDM2/TRIP11/LY6E/HES1/ENG 12 GO:1904738 vascular associated smooth muscle cell migration 7/725 50/18722 0.00297267891544853 0.0305030555109486 LRP1/GNA12/NFE2L2/RHOA/ADAMTS1/MDM2/IQGAP1 7 GO:0031647 regulation of protein stability 22/725 298/18722 0.00300168622640178 0.0306739337974445 GAPDH/AAK1/PLPP3/HSPD1/HSPA8/PRKDC/USP27X/CTNND1/GRN/SOX4/NPM1/TRIM44/TBL1X/ZSWIM7/GNAQ/BCL2/HSPA1A/MDM2/PFN1/MYLIP/USP9X/RTN4 22 GO:0009755 hormone-mediated signaling pathway 16/725 190/18722 0.00300748571657722 0.0306739337974445 LGR5/LGR4/DDX5/ISL1/PARP1/RHOA/BMP7/CSNK2B/ESRRA/LATS2/GHR/UFL1/NR3C1/DDX17/UBA5/ESRRG 16 GO:0030041 actin filament polymerization 16/725 190/18722 0.00300748571657722 0.0306739337974445 IQGAP2/KANK1/ARHGAP18/TRIOBP/TMSB4X/RHOA/PPP1R9A/COBL/WASF2/DLG1/ARPC3/PFN1/RASA1/RAC1/ARF1/CAPZB 16 GO:0000910 cytokinesis 15/725 173/18722 0.00303455764465777 0.0308585980851137 SON/MYH10/CALM1/RHOA/ROCK1/PKN2/PLEC/RHOB/BIRC6/CDC42/UVRAG/RASA1/SETD2/RAB11A/ARF1 15 GO:0010506 regulation of autophagy 23/725 317/18722 0.00303776690559711 0.0308585980851137 GAPDH/EEF1A1/MET/ATP6V0E1/PSAP/HSPB1/BNIP3L/TFEB/ROCK1/USP10/BCL2/LARP1/HSPB8/UFL1/EXOC1/RALB/UVRAG/PIP4K2A/DDIT3/RIPK2/HMGB1/PIK3CB/ATP6V1G1 23 GO:0030177 positive regulation of Wnt signaling pathway 13/725 140/18722 0.00311219158882922 0.0315513983275506 WLS/CAV1/LGR5/LGR4/KANK1/EGFR/MACF1/RPS12/RBPJ/SOX4/GPC3/TBL1X/ATP6AP2 13 GO:0070373 negative regulation of ERK1 and ERK2 cascade 9/725 78/18722 0.00312617639475861 0.0316299164571485 FBLN1/SEMA6A/DUSP1/DUSP6/EZR/DUSP9/DLG1/ATF3/TIMP3 9 GO:0051495 positive regulation of cytoskeleton organization 18/725 226/18722 0.00313422030509414 0.0316412905301638 IQGAP2/AKAP9/CLIP1/MET/RHOA/DYNC1H1/WASF2/HSPA1A/DLG1/GPSM2/ARPC3/PFN1/MTSS1/CDC42/HRAS/NUMA1/RAC1/ARF1 18 GO:0006898 receptor-mediated endocytosis 19/725 244/18722 0.00313978479713403 0.0316412905301638 CAV1/ITGB1/LRP1/AAK1/CD63/LRP2/TFRC/ITGAV/EZR/CTSL/LRPAP1/CLTC/APELA/SERPINE1/RAC1/ARF1/PIK3CB/SDCBP/B2M 19 GO:0010508 positive regulation of autophagy 12/725 124/18722 0.00315257776993246 0.0317071760233882 BNIP3L/TFEB/ROCK1/LARP1/HSPB8/UFL1/RALB/UVRAG/PIP4K2A/RIPK2/HMGB1/PIK3CB 12 GO:0097242 amyloid-beta clearance 6/725 38/18722 0.00316346406230151 0.0317536620431809 LRP1/LRP2/LRPAP1/ROCK1/CLTC/RAB11A 6 GO:0051591 response to cAMP 10/725 93/18722 0.00318195989682838 0.0318761950929309 LDHA/AKAP9/FOS/APP/JUN/DUSP1/FOSB/EZR/HSPA5/FDX1 10 GO:2000377 regulation of reactive oxygen species metabolic process 14/725 157/18722 0.00319205171900717 0.0319142212300736 HSPD1/EGFR/NFE2L2/RHOA/BMP7/STK17A/BCL2/CDKN1A/TFAP2A/CFLAR/ARF4/RAC1/ARG2/CYBA 14 GO:0006470 protein dephosphorylation 21/725 281/18722 0.00319911019346018 0.0319218298634836 SLC39A10/DUSP1/CTDSPL/CALM1/DUSP6/HSP90B1/PTPRA/PHLPP1/CSNK2B/ROCK1/BCL2/PTPN14/BOD1L1/CAMK2G/DLG1/PPP6R2/PTPN12/PPP1R15A/PTPRF/PHPT1/PPIA 21 GO:0048639 positive regulation of developmental growth 15/725 174/18722 0.00320559764992857 0.0319237219793475 IGF2/LRP1/BASP1/TGFBR3/PRKDC/MACF1/RBPJ/GOLGA4/EZR/BCL2/GHR/NIPBL/HOPX/RAB11A/SERP1 15 GO:0070663 regulation of leukocyte proliferation 19/725 245/18722 0.00328429744281818 0.0326433406620497 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 19 GO:0008584 male gonad development 13/725 141/18722 0.00331029174646172 0.0328373167569754 ADGRG1/LRP2/SF1/FSTL3/NASP/CTSV/ATRX/BCL2/ARID5B/EIF2S2/KDM5A/INHA/RHOBTB3 13 GO:0051293 establishment of spindle localization 7/725 51/18722 0.00333283321810515 0.0329963507472168 ITGB1/GJA1/DYNC1H1/CFL1/GPSM2/KPNB1/NUMA1 7 GO:0048771 tissue remodeling 15/725 175/18722 0.00338448352065575 0.0333338565809852 CAV1/LGR4/TFRC/EGFR/GJA1/RBPJ/LRP5/NF1/SUCO/ROCK1/BGN/MDM2/SYT7/RAC1/TMBIM1 15 GO:0042063 gliogenesis 22/725 301/18722 0.00338665143799711 0.0333338565809852 SPINT1/ITGB4/LRP1/ADGRG1/LRP2/APP/DAG1/S100A9/LAMB1/EGFR/ANXA1/GRN/SOX4/GLI3/IL6ST/RHOA/NF1/DICER1/PLEC/UFL1/HES1/RTN4 22 GO:0042886 amide transport 22/725 301/18722 0.00338665143799711 0.0333338565809852 DYNLL1/LRP1/LRP2/KIF5B/EGFR/GJA1/ANXA1/ISL1/SOX4/ABCB1/LRP5/PSAP/GLUL/CAMK2G/SYT7/HMGN3/MPC2/SRI/SERP1/RAB1A/PHPT1/RAC1 22 GO:0032868 response to insulin 20/725 264/18722 0.0033965862132193 0.033366851772885 ATP2B1/IGF2/KANK1/PKM/PRKDC/PARP1/LPIN2/PTPRA/SOCS1/ESRRA/GHR/SLC9A1/ZNF106/CAT/HADHA/SRSF6/SLC2A8/PIP4K2A/VAMP2/CFLAR 20 GO:0010586 miRNA metabolic process 5/725 27/18722 0.00341218306697541 0.0334552339777531 KCNQ1OT1/DICER1/DDX17/HRAS/AGO2 5 GO:1902414 protein localization to cell junction 10/725 94/18722 0.003440433394803 0.0336670982205722 DLG5/DAG1/KIF5B/JAM3/HSPB1/ACTG1/DLG1/HRAS/VAMP2/RAB11A 10 GO:0060389 pathway-restricted SMAD protein phosphorylation 8/725 65/18722 0.00349842924750654 0.0341686663884598 LRP1/TGFBR3/BMP7/CSNK2B/INHA/GDF15/ENG/SDCBP 8 GO:0046546 development of primary male sexual characteristics 13/725 142/18722 0.0035185227484812 0.0342988304077908 ADGRG1/LRP2/SF1/FSTL3/NASP/CTSV/ATRX/BCL2/ARID5B/EIF2S2/KDM5A/INHA/RHOBTB3 13 GO:2000811 negative regulation of anoikis 4/725 17/18722 0.00354617752712667 0.0345020611996259 CAV1/ITGB1/BCL2/TLE1 4 GO:0048259 regulation of receptor-mediated endocytosis 11/725 110/18722 0.00358163654589448 0.0347802981822588 AAK1/CD63/ITGAV/LRPAP1/APELA/SERPINE1/RAC1/ARF1/PIK3CB/SDCBP/B2M 11 GO:0007409 axonogenesis 28/725 418/18722 0.00361605090101705 0.0348893276325223 NRP2/ITGB1/RPL24/LRP1/SEMA6D/APP/DAG1/SEMA6A/KIF5B/EPHB4/LAMA5/MACF1/ISL1/GOLGA4/GLI3/MYCBP2/BMP7/COBL/B3GNT2/BCL2/AFG3L2/C12orf57/USP9X/SEMA4C/RAB11A/RTN4/S100A6/RAC1 28 GO:0051084 'de novo' posttranslational protein folding 6/725 39/18722 0.00361844321365314 0.0348893276325223 HSPA8/HSPA5/HSPA1A/ERO1A/DNAJB14/DNAJB4 6 GO:0090224 regulation of spindle organization 6/725 39/18722 0.00361844321365314 0.0348893276325223 DYNC1H1/CLTC/HSPA1A/GPSM2/NUMA1/CCSAP 6 GO:0022409 positive regulation of cell-cell adhesion 21/725 284/18722 0.00362039580483463 0.0348893276325223 CAV1/IGF2/CD46/TFRC/PLPP3/HSPD1/ANXA1/FSTL3/PNP/SOX4/GLI3/IL6ST/RHOA/BMP7/SOCS1/NFAT5/CD55/HES1/RIPK2/HMGB1/B2M 21 GO:0001570 vasculogenesis 9/725 80/18722 0.0037134415886486 0.0355623435316909 CAV1/ITGAV/TGFBR3/APELA/QKI/AMOT/RASA1/SETD2/ENG 9 GO:0071229 cellular response to acid chemical 9/725 80/18722 0.0037134415886486 0.0355623435316909 NEURL1/DNMT3A/SOCS1/CEBPB/SLC38A9/PLEC/CPEB4/DNMT1/CYBA 9 GO:0008585 female gonad development 10/725 95/18722 0.00371530320641275 0.0355623435316909 NR2F2/IDH1/HSPA5/ADAMTS1/BCL2/CEBPB/ARID5B/INHA/ZFX/CYP19A1 10 GO:0032206 positive regulation of telomere maintenance 7/725 52/18722 0.00372531158321718 0.0355623435316909 MAP3K4/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1 7 GO:0060147 regulation of posttranscriptional gene silencing 7/725 52/18722 0.00372531158321718 0.0355623435316909 NEAT1/KCNQ1OT1/EGFR/DDX5/PUM1/TNRC6B/AGO2 7 GO:0030010 establishment of cell polarity 13/725 143/18722 0.00373725892437752 0.0356093336234392 ITGB1/KANK1/GJA1/RHOA/JAM3/FRMD4B/ROCK1/GPSM2/CDC42/HES1/AMOT/NUMA1/SNX27 13 GO:0030324 lung development 15/725 177/18722 0.00376686175693943 0.0357569704979887 DLG5/DAG1/EGFR/LAMA5/RBPJ/FSTL3/GLI3/GPC3/RDH10/MAN1A2/SRSF6/CDC42/HOPX/HES1/HMGB1 15 GO:0043405 regulation of MAP kinase activity 15/725 177/18722 0.00376686175693943 0.0357569704979887 CAV1/MAP3K4/DUSP1/MAGED1/EGFR/PDCD4/NF1/BMP7/GHR/IQGAP1/SASH1/HRAS/ERP29/FLT1/PIK3CB 15 GO:0090316 positive regulation of intracellular protein transport 14/725 160/18722 0.00378745450554487 0.0358852465207606 TCAF1/KIF5B/CDH1/STOM/GLI3/OAZ1/NMT1/B3GAT3/MDM2/HUWE1/CDC42/HRAS/VAMP2/UBE2D3 14 GO:0014015 positive regulation of gliogenesis 8/725 66/18722 0.00384905513152177 0.0364008590703057 SPINT1/LRP2/DAG1/EGFR/IL6ST/DICER1/UFL1/HES1 8 GO:0045732 positive regulation of protein catabolic process 18/725 231/18722 0.00394952136235148 0.0372814223198504 CAV1/LRP1/LRP2/CTSC/DDB1/GJA1/NFE2L2/EZR/PTTG1IP/OAZ1/GPC3/HERPUD1/HSPA1A/MDM2/HUWE1/DDA1/MYLIP/CBLB 18 GO:0010769 regulation of cell morphogenesis involved in differentiation 10/725 96/18722 0.00400728338161955 0.0375549644212809 FBLN1/CUX1/KANK1/PRKDC/TRIOBP/P4HB/DHX36/CDC42/TACSTD2/RAC1 10 GO:0030510 regulation of BMP signaling pathway 10/725 96/18722 0.00400728338161955 0.0375549644212809 FBN1/LRP2/RBPJ/FSTL3/CRIM1/GPC3/HES1/NUMA1/UBE2D3/ENG 10 GO:0032607 interferon-alpha production 5/725 28/18722 0.00402364488694163 0.0375549644212809 HSPD1/DHX36/SETD2/RIPK2/HMGB1 5 GO:0032647 regulation of interferon-alpha production 5/725 28/18722 0.00402364488694163 0.0375549644212809 HSPD1/DHX36/SETD2/RIPK2/HMGB1 5 GO:0032801 receptor catabolic process 5/725 28/18722 0.00402364488694163 0.0375549644212809 RNF43/ZNRF3/LGMN/UVRAG/MYLIP 5 GO:1990776 response to angiotensin 5/725 28/18722 0.00402364488694163 0.0375549644212809 CAV1/NFE2L2/ROCK1/IQGAP1/CYBA 5 GO:0060968 regulation of gene silencing 9/725 81/18722 0.00403776989733638 0.0375549644212809 NEAT1/KCNQ1OT1/EGFR/DDX5/MPHOSPH8/PUM1/TNRC6B/AGO2/DNMT1 9 GO:0071260 cellular response to mechanical stimulus 9/725 81/18722 0.00403776989733638 0.0375549644212809 DAG1/TMEM150C/EGFR/GJA1/PLEC/SLC9A1/ENG/RAC1/CYBA 9 GO:0090276 regulation of peptide hormone secretion 16/725 196/18722 0.00408151563622381 0.0378923127472866 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/LRP5/GLUL/SYT7/HMGN3/MPC2/SRI/SERP1/PHPT1/RAC1 16 GO:0048640 negative regulation of developmental growth 11/725 112/18722 0.0041138708105811 0.0380428601050042 SEMA6D/SEMA6A/ADRB1/GJA1/SLC6A4/SPAG9/LGMN/CDKN1A/SEMA4C/RTN4/GDF15 11 GO:0045740 positive regulation of DNA replication 6/725 40/18722 0.00412024663595331 0.0380428601050042 JUN/EGFR/ATRX/CDC42/HRAS/RAC1 6 GO:0071526 semaphorin-plexin signaling pathway 6/725 40/18722 0.00412024663595331 0.0380428601050042 NRP2/SEMA6D/SEMA6A/MET/SEMA4C/RAC1 6 GO:0007566 embryo implantation 7/725 53/18722 0.00415192032980615 0.038196159985095 SYDE1/FBLN1/ITGB4/GJA1/RPL29/APELA/AGO2 7 GO:0060966 regulation of gene silencing by RNA 7/725 53/18722 0.00415192032980615 0.038196159985095 NEAT1/KCNQ1OT1/EGFR/DDX5/PUM1/TNRC6B/AGO2 7 GO:0050767 regulation of neurogenesis 25/725 364/18722 0.00421288885637404 0.0386868362553624 SPINT1/LRP1/CUX1/SEMA6D/LRP2/DAG1/SEMA6A/EGFR/NEURL1/MACF1/GOLGA4/GLI3/IL6ST/NF1/BMP7/HOOK3/DHX36/DICER1/UFL1/SERPINF1/HES1/SEMA4C/RAB11A/RTN4/B2M 25 GO:0061077 chaperone-mediated protein folding 8/725 67/18722 0.00422620641869894 0.0387389517836979 HSPA8/HSPB1/HSPA5/HSPA1A/ERO1A/DNAJB14/DNAJB4/PDIA4 8 GO:0034599 cellular response to oxidative stress 21/725 288/18722 0.00425330442509904 0.0389169677451752 FOS/JUN/SOD3/EGFR/DHRS2/ANXA1/MET/PARP1/NFE2L2/HSPB1/BMP7/P4HB/BCL2/ARL6IP5/FUT8/HSPA1A/MDM2/RHOB/NET1/CHCHD2/PPIA 21 GO:0010952 positive regulation of peptidase activity 16/725 197/18722 0.00428784214244655 0.0390475923272669 CAV1/FBLN1/APP/PMAIP1/S100A9/HSPD1/PDCD6/GRN/RHOA/LGMN/CLDN4/ARL6IP5/ASPH/CFLAR/RIPK2/HMGB1 16 GO:0016570 histone modification 30/725 463/18722 0.00429069025967403 0.0390475923272669 IGF2/BRD4/KMT2C/DDB1/ISL1/TET2/SKP1/ATRX/TBL1X/ZNF451/ASH1L/BRD7/NCOA3/PHF20/UFL1/USP22/NIPBL/KDM5A/RTF1/HUWE1/HOPX/RCOR1/BAZ1B/EID1/KDM5B/DNMT1/SETD2/MBD3/MORF4L2/UBE2A 30 GO:0023061 signal release 30/725 463/18722 0.00429069025967403 0.0390475923272669 DYNLL1/WLS/LRP1/KIF5B/EGFR/GJA1/TBX3/ANXA1/CALM1/ISL1/SOX4/LRP5/PPP1R9A/SLC6A4/GLUL/RAB11FIP1/CAMK2G/SYT7/C1QTNF1/HMGN3/MPC2/INHA/KDM5B/VAMP2/SRI/SERP1/RAB1A/PHPT1/RAC1/CYP19A1 30 GO:0044772 mitotic cell cycle phase transition 28/725 424/18722 0.00439550819115727 0.0398783683039169 ITGB1/RPL24/BRD4/APP/PRKDC/DUSP1/DDB1/EGFR/RPS6/CTDSPL/ANXA1/CALM1/NASP/SOX4/ABCB1/RPL26/PBX1/ADAMTS1/BRD7/LATS2/BCL2/DLG1/MDM2/NEK6/CDKN1A/RAB11A/BACH1/CENPF 28 GO:0031623 receptor internalization 11/725 113/18722 0.00440263306120293 0.0398783683039169 CAV1/ITGB1/LRP1/CD63/TFRC/EZR/LRPAP1/CLTC/APELA/ARF1/SDCBP 11 GO:0048660 regulation of smooth muscle cell proliferation 15/725 180/18722 0.00440608078835717 0.0398783683039169 JUN/AKR1B1/IGFBP3/PRKDC/SF1/EGFR/GJA1/PDCD4/GNA12/RHOA/ADAMTS1/MDM2/CDKN1A/DNMT1/CYBA 15 GO:0036499 PERK-mediated unfolded protein response 4/725 18/18722 0.00442131445784204 0.0398783683039169 NFE2L2/HSPA5/PPP1R15A/DDIT3 4 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 4/725 18/18722 0.00442131445784204 0.0398783683039169 TBX3/ISL1/RBPJ/HES1 4 GO:0042542 response to hydrogen peroxide 13/725 146/18722 0.00446034494539857 0.0401060221779308 LDHA/JUN/HSPD1/DUSP1/ANXA1/MET/TXNIP/NFE2L2/BCL2/MDM2/RHOB/CAT/NET1 13 GO:0010976 positive regulation of neuron projection development 14/725 163/18722 0.00447029049724421 0.0401060221779308 TENM3/LRP1/S100A9/ITGA6/NFE2L2/GRN/PPP1R9A/BMP7/COBL/HSPA5/DHX36/IQGAP1/SERPINF1/CFLAR 14 GO:0071322 cellular response to carbohydrate stimulus 14/725 163/18722 0.00447029049724421 0.0401060221779308 DYNLL1/LRP1/KIF5B/SOX4/LRP5/COLEC12/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 14 GO:0009612 response to mechanical stimulus 17/725 216/18722 0.00453578423082218 0.0405500710159393 FOS/DAG1/JUN/JUND/TMEM150C/EGFR/GJA1/FOSB/BTG2/TXNIP/RHOA/PLEC/SLC9A1/USP53/ENG/RAC1/CYBA 17 GO:0050870 positive regulation of T cell activation 17/725 216/18722 0.00453578423082218 0.0405500710159393 CAV1/IGF2/CD46/TFRC/HSPD1/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/CD55/HES1/RIPK2/HMGB1/B2M 17 GO:0010812 negative regulation of cell-substrate adhesion 8/725 68/18722 0.00463117181304248 0.0412438455717622 FBLN1/LRP1/KANK1/RHOA/PHLDB2/RASA1/TACSTD2/SERPINE1 8 GO:1902305 regulation of sodium ion transmembrane transport 8/725 68/18722 0.00463117181304248 0.0412438455717622 FXYD3/UTRN/KIF5B/STOM/SLC9A1/DLG1/ARF1/GLRX 8 GO:0030323 respiratory tube development 15/725 181/18722 0.00463779679934986 0.0412438455717622 DLG5/DAG1/EGFR/LAMA5/RBPJ/FSTL3/GLI3/GPC3/RDH10/MAN1A2/SRSF6/CDC42/HOPX/HES1/HMGB1 15 GO:0007041 lysosomal transport 11/725 114/18722 0.00470727543002285 0.0413046651287673 LRP1/HSPA8/GRN/PSAP/HOOK3/HSPA1A/RHOB/HGSNAT/SNX27/ARF1/ARL8B 11 GO:0021987 cerebral cortex development 11/725 114/18722 0.00470727543002285 0.0413046651287673 LRP1/ADGRG1/LAMB1/TACC2/GLI3/RHOA/NF1/TRA2B/GNG12/BTBD3/RTN4 11 GO:0022011 myelination in peripheral nervous system 5/725 29/18722 0.00470954146039223 0.0413046651287673 ITGB4/DAG1/NF1/DICER1/PLEC 5 GO:0032292 peripheral nervous system axon ensheathment 5/725 29/18722 0.00470954146039223 0.0413046651287673 ITGB4/DAG1/NF1/DICER1/PLEC 5 GO:0040018 positive regulation of multicellular organism growth 5/725 29/18722 0.00470954146039223 0.0413046651287673 IGF2/EZR/BCL2/GHR/NIPBL 5 GO:0050686 negative regulation of mRNA processing 5/725 29/18722 0.00470954146039223 0.0413046651287673 SAP18/NPM1/SRSF9/SRSF7/SRSF6 5 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 5/725 29/18722 0.00470954146039223 0.0413046651287673 PARP1/NFE2L2/HSPB1/P4HB/PPIA 5 GO:0050680 negative regulation of epithelial cell proliferation 14/725 164/18722 0.0047188776379258 0.0413046651287673 CAV1/TGFBR3/MAGED1/GJA1/NR2F2/ISL1/NF1/GPC3/DLG1/MTSS1/SERPINF1/CDKN1C/FLT1/B2M 14 GO:0045930 negative regulation of mitotic cell cycle 18/725 235/18722 0.00472144669764891 0.0413046651287673 PRKDC/DUSP1/EGFR/CTDSPL/BTG3/BTG2/SOX4/RPL26/BMP7/BRD7/PPP1R10/BCL2/DLG1/MDM2/CDKN1A/CDKN1C/CENPF/TIMP2 18 GO:0042098 T cell proliferation 16/725 199/18722 0.00472612068942297 0.0413046651287673 IGF2/DLG5/CD46/TFRC/RPS6/ANXA1/PNP/IL6ST/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/CBLB 16 GO:0008154 actin polymerization or depolymerization 17/725 217/18722 0.00474976293929863 0.0413928975538929 IQGAP2/KANK1/ARHGAP18/TRIOBP/TMSB4X/RHOA/PPP1R9A/COBL/WASF2/CFL1/DLG1/ARPC3/PFN1/RASA1/RAC1/ARF1/CAPZB 17 GO:0050886 endocrine process 9/725 83/18722 0.00475254811133669 0.0413928975538929 GJA1/TBX3/ENPEP/RHOA/RAB11FIP1/ATP6AP2/C1QTNF1/INHA/CYBA 9 GO:0019079 viral genome replication 12/725 131/18722 0.00492278853637867 0.0427287929638759 HACD3/HSPA8/DDB1/DDX5/STOM/MPHOSPH8/BCL2/LARP1/PKN2/DEK/CDC42/PPIA 12 GO:0019827 stem cell population maintenance 12/725 131/18722 0.00492278853637867 0.0427287929638759 TPT1/TBX3/RBPJ/ZC3H13/SOX4/LRP5/BMP7/HOOK3/NCOA3/NIPBL/RTF1/HES1 12 GO:0002791 regulation of peptide secretion 16/725 200/18722 0.00495858290854114 0.0429659089972565 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/LRP5/GLUL/SYT7/HMGN3/MPC2/SRI/SERP1/PHPT1/RAC1 16 GO:0014074 response to purine-containing compound 13/725 148/18722 0.00500209597890959 0.043195271749732 LDHA/AKAP9/FOS/APP/JUN/HSPD1/DUSP1/FOSB/EZR/HSP90B1/SLC6A4/HSPA5/FDX1 13 GO:0070507 regulation of microtubule cytoskeleton organization 13/725 148/18722 0.00500209597890959 0.043195271749732 AKAP9/CLIP1/MET/RHOA/DYNC1H1/ROCK1/CLTC/HSPA1A/GPSM2/PHLDB2/NUMA1/CCSAP/RAC1 13 GO:1901224 positive regulation of NIK/NF-kappaB signaling 8/725 69/18722 0.0050652568604433 0.0436663044652842 APP/EGFR/PDCD4/RHOA/TRIM44/NFAT5/SASH1/HMGB1 8 GO:0001755 neural crest cell migration 7/725 55/18722 0.00511486186460318 0.0438701096305813 NRP2/SEMA6D/SEMA6A/LAMA5/ISL1/BMP7/SEMA4C 7 GO:0038066 p38MAPK cascade 7/725 55/18722 0.00511486186460318 0.0438701096305813 MAP3K4/DUSP1/GADD45B/EZR/PHLPP1/DLG1/SASH1 7 GO:0043331 response to dsRNA 7/725 55/18722 0.00511486186460318 0.0438701096305813 CAV1/PMAIP1/NPM1/COLEC12/DHX36/RALB/RIPK2 7 GO:0003002 regionalization 23/725 331/18722 0.00513932792110935 0.0439792056911128 NRP2/WLS/BASP1/ADGRG1/LRP2/PRKDC/TBX3/NR2F2/BTG2/ISL1/RBPJ/GLI3/PBX1/LRP5/GPC3/COBL/BPTF/MIB1/TRA2B/IRX2/ATP6AP2/HES1/DDIT3 23 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 9/725 84/18722 0.00514493370977113 0.0439792056911128 PRKDC/CTDSPL/SOX4/RPL26/BRD7/BCL2/DLG1/MDM2/CDKN1A 9 GO:0009411 response to UV 13/725 149/18722 0.00529210168987528 0.0451610496060233 MAP3K4/DDB1/EGFR/PARP1/RPL26/OPN3/NPM1/DHX36/BCL2/MDM2/CAT/CDKN1A/UBE2A 13 GO:0044728 DNA methylation or demethylation 10/725 100/18722 0.00536101839023002 0.0452698559450768 FOS/PARP1/TET2/MPHOSPH8/DNMT3A/ATRX/TDG/DNMT1/USP9X/MBD3 10 GO:0046545 development of primary female sexual characteristics 10/725 100/18722 0.00536101839023002 0.0452698559450768 NR2F2/IDH1/HSPA5/ADAMTS1/BCL2/CEBPB/ARID5B/INHA/ZFX/CYP19A1 10 GO:0060840 artery development 10/725 100/18722 0.00536101839023002 0.0452698559450768 ADAMTS6/LRP1/LRP2/RBPJ/SOX4/GLI3/NF1/GJA5/HES1/ENG 10 GO:0021782 glial cell development 11/725 116/18722 0.00536660584878485 0.0452698559450768 ITGB4/LRP1/APP/DAG1/S100A9/EGFR/GRN/SOX4/NF1/DICER1/PLEC 11 GO:0030326 embryonic limb morphogenesis 11/725 116/18722 0.00536660584878485 0.0452698559450768 FBN2/TBX3/GLI3/PBX1/LRP5/BMP7/GPC3/FRAS1/RDH10/NIPBL/TFAP2A 11 GO:0035113 embryonic appendage morphogenesis 11/725 116/18722 0.00536660584878485 0.0452698559450768 FBN2/TBX3/GLI3/PBX1/LRP5/BMP7/GPC3/FRAS1/RDH10/NIPBL/TFAP2A 11 GO:0048659 smooth muscle cell proliferation 15/725 184/18722 0.00539299331731456 0.0452698559450768 JUN/AKR1B1/IGFBP3/PRKDC/SF1/EGFR/GJA1/PDCD4/GNA12/RHOA/ADAMTS1/MDM2/CDKN1A/DNMT1/CYBA 15 GO:0034765 regulation of ion transmembrane transport 31/725 491/18722 0.0054225659568315 0.0452698559450768 CLIC3/TCAF1/C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/CD63/APP/KIF5B/KCNN4/STOM/CALM1/TMSB4X/TMEM37/ABCB1/PDE4B/HOMER1/GJA5/ARL6IP5/GOPC/SLC9A1/DLG1/VAMP2/SRI/CLIC1/ARF1/GLRX/GSTO1/CYBA 31 GO:0000028 ribosomal small subunit assembly 4/725 19/18722 0.00543099714122878 0.0452698559450768 PRKDC/RPS19/RPS5/RPSA 4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 4/725 19/18722 0.00543099714122878 0.0452698559450768 SOX4/RPL26/MDM2/CDKN1A 4 GO:0045947 negative regulation of translational initiation 4/725 19/18722 0.00543099714122878 0.0452698559450768 RPL13A/LARP1/AGO2/PAIP2 4 GO:0061323 cell proliferation involved in heart morphogenesis 4/725 19/18722 0.00543099714122878 0.0452698559450768 TBX3/ISL1/RBPJ/HES1 4 GO:0090087 regulation of peptide transport 16/725 202/18722 0.00545145710505741 0.0452698559450768 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ISL1/SOX4/LRP5/GLUL/SYT7/HMGN3/MPC2/SRI/SERP1/PHPT1/RAC1 16 GO:0031571 mitotic G1 DNA damage checkpoint signaling 5/725 30/18722 0.00547453574557745 0.0452698559450768 PRKDC/SOX4/RPL26/MDM2/CDKN1A 5 GO:0045070 positive regulation of viral genome replication 5/725 30/18722 0.00547453574557745 0.0452698559450768 HACD3/DDB1/LARP1/PKN2/PPIA 5 GO:0060674 placenta blood vessel development 5/725 30/18722 0.00547453574557745 0.0452698559450768 SPINT1/NR2F2/RBPJ/APELA/HES1 5 GO:0061384 heart trabecula morphogenesis 5/725 30/18722 0.00547453574557745 0.0452698559450768 TGFBR3/RBPJ/BMP7/ADAMTS1/ENG 5 GO:1902751 positive regulation of cell cycle G2/M phase transition 5/725 30/18722 0.00547453574557745 0.0452698559450768 BRD4/APP/PBX1/NPM1/RAB11A 5 GO:2000637 positive regulation of gene silencing by miRNA 5/725 30/18722 0.00547453574557745 0.0452698559450768 EGFR/DDX5/PUM1/TNRC6B/AGO2 5 GO:0030433 ubiquitin-dependent ERAD pathway 9/725 85/18722 0.00556196238519372 0.0459178946751579 CAV1/NFE2L2/HSP90B1/HSPA5/UBXN4/HERPUD1/CCDC47/DNAJB14/SEC61B 9 GO:1903039 positive regulation of leukocyte cell-cell adhesion 18/725 239/18722 0.00561323594328379 0.0462474966741718 CAV1/IGF2/CD46/TFRC/HSPD1/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/NFAT5/CD55/HES1/RIPK2/HMGB1/B2M 18 GO:0051653 spindle localization 7/725 56/18722 0.00565490304885054 0.0462474966741718 ITGB1/GJA1/DYNC1H1/CFL1/GPSM2/KPNB1/NUMA1 7 GO:0071385 cellular response to glucocorticoid stimulus 7/725 56/18722 0.00565490304885054 0.0462474966741718 ATP2B1/EGFR/ANXA1/ISL1/NR3C1/SERPINF1/CFLAR 7 GO:0040015 negative regulation of multicellular organism growth 3/725 10/18722 0.00565852957921669 0.0462474966741718 ADRB1/LGMN/GDF15 3 GO:0051409 response to nitrosative stress 3/725 10/18722 0.00565852957921669 0.0462474966741718 DUSP6/ADH5/DDIT3 3 GO:0098885 modification of postsynaptic actin cytoskeleton 3/725 10/18722 0.00565852957921669 0.0462474966741718 MYH10/RHOA/PFN1 3 GO:0051896 regulation of protein kinase B signaling 15/725 185/18722 0.00566575171328875 0.0462474966741718 ITGB1/IGF2/LRP2/DAG1/EGFR/MET/PDCD6/PHLPP1/DLG1/C1QTNF1/RTN4/GDF15/DDIT3/ENG/PIK3CB 15 GO:0060541 respiratory system development 16/725 203/18722 0.00571240168870469 0.0465533185852799 DLG5/BASP1/DAG1/EGFR/LAMA5/RBPJ/FSTL3/GLI3/GPC3/RDH10/MAN1A2/SRSF6/CDC42/HOPX/HES1/HMGB1 16 GO:0042102 positive regulation of T cell proliferation 10/725 101/18722 0.00574968178186911 0.0467819212717408 IGF2/CD46/TFRC/ANXA1/PNP/IL6ST/CD55/HES1/RIPK2/HMGB1 10 GO:0001508 action potential 12/725 134/18722 0.00589050245980576 0.0476980143270853 AKAP9/CAV1/GJA1/CALM1/DSG2/GJA5/GNAQ/SLC9A1/DLG1/DSC2/USP53/SRI 12 GO:0042552 myelination 12/725 134/18722 0.00589050245980576 0.0476980143270853 ITGB4/DAG1/CTSC/NF1/JAM3/DICER1/AFG3L2/PLEC/DLG1/CMTM8/QKI/EPB41L3 12 GO:0098727 maintenance of cell number 12/725 134/18722 0.00589050245980576 0.0476980143270853 TPT1/TBX3/RBPJ/ZC3H13/SOX4/LRP5/BMP7/HOOK3/NCOA3/NIPBL/RTF1/HES1 12 GO:0048592 eye morphogenesis 13/725 151/18722 0.00591247044466114 0.0477234278407441 FBN1/FBN2/TENM3/EFEMP1/GLI3/LRP5/NF1/BMP7/BCL2/NIPBL/C12orf57/TFAP2A/RDH13 13 GO:0071333 cellular response to glucose stimulus 13/725 151/18722 0.00591247044466114 0.0477234278407441 DYNLL1/LRP1/KIF5B/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 13 GO:0014002 astrocyte development 6/725 43/18722 0.00593454776590101 0.0477495597227813 LRP1/APP/S100A9/EGFR/GRN/NF1 6 GO:0046636 negative regulation of alpha-beta T cell activation 6/725 43/18722 0.00593454776590101 0.0477495597227813 ANXA1/GLI3/SOCS1/HMGB1/ARG2/CBLB 6 GO:0071383 cellular response to steroid hormone stimulus 16/725 204/18722 0.00598337895875857 0.0480661615561762 ATP2B1/EGFR/DDX5/ANXA1/ISL1/PARP1/RHOA/BMP7/ESRRA/UFL1/NR3C1/DDX17/UBA5/SERPINF1/CFLAR/ESRRG 16 GO:0001558 regulation of cell growth 27/725 414/18722 0.00600231900803584 0.0481063256945219 LRP1/SEMA6D/SEMA6A/S100A9/EGFR/GJA1/MACF1/GOLGA4/RHOA/ENO1/NPM1/SPAG9/BCL2/CHPT1/HSPA1A/SLC9A1/NET1/SERTAD2/CDC42/CDKN1A/EPB41L3/SEMA4C/RAB11A/RTN4/SGK1/SDCBP/CYBA 27 GO:0042391 regulation of membrane potential 28/725 434/18722 0.00600735927493241 0.0481063256945219 AKAP9/CAV1/APP/JUN/PMAIP1/KIF5B/ADRB1/GJA1/GABRE/KCNN4/CALM1/PARP1/PPP1R9A/BNIP3L/SLC25A36/DSG2/GJA5/GNAQ/BCL2/ARL6IP5/SLC9A1/DLG1/DSC2/USP53/SRI/CLIC1/GLRX/CHCHD10 28 GO:0071230 cellular response to amino acid stimulus 8/725 71/18722 0.00602607998639679 0.0481801253171062 NEURL1/DNMT3A/SOCS1/CEBPB/SLC38A9/CPEB4/DNMT1/CYBA 8 GO:0051101 regulation of DNA binding 11/725 118/18722 0.00609675781828566 0.0486684494187244 JUN/CALM1/ISL1/PARP1/TMSB4X/EDF1/CSNK2B/HES1/DDIT3/HMGB1/SRI 11 GO:0044843 cell cycle G1/S phase transition 18/725 241/18722 0.00610818329910219 0.0486829892187878 ITGB1/BRD4/PRKDC/EGFR/RPS6/CTDSPL/ANXA1/NASP/SOX4/RPL26/ADAMTS1/BRD7/LATS2/BCL2/DLG1/MDM2/CDKN1A/BACH1 18 GO:0021543 pallium development 14/725 169/18722 0.00613474952956807 0.0487455981141496 LRP1/ADGRG1/KIF5B/LAMB1/TACC2/BTG2/GLI3/RHOA/NF1/TRA2B/GNG12/BTBD3/HSD3B1/RTN4 14 GO:1903037 regulation of leukocyte cell-cell adhesion 23/725 336/18722 0.00613527157167636 0.0487455981141496 CAV1/IGF2/DLG5/CD46/TFRC/HSPD1/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/NFAT5/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/B2M/CBLB 23 GO:0001841 neural tube formation 10/725 102/18722 0.00615998295875429 0.048865342125079 SPINT1/LRP2/SOX4/BMP7/COBL/MIB1/PFN1/BRD2/SETD2/SEMA4C 10 GO:1900024 regulation of substrate adhesion-dependent cell spreading 7/725 57/18722 0.00623648337006861 0.0492979135708636 FBLN1/KANK1/TRIOBP/P4HB/CDC42/TACSTD2/RAC1 7 GO:0021915 neural tube development 13/725 152/18722 0.00624368919165405 0.0492979135708636 SPINT1/LRP2/SOX4/GLI3/BMP7/COBL/MIB1/ATP6AP2/PFN1/BRD2/HES1/SETD2/SEMA4C 13 GO:0098754 detoxification 13/725 152/18722 0.00624368919165405 0.0492979135708636 GPX3/PRDX6/SOD3/S100A9/NFE2L2/ABCB1/BMP7/GPX4/CAT/ADH5/TXNRD1/GLRX/GSTO1 13 GO:0044819 mitotic G1/S transition checkpoint signaling 5/725 31/18722 0.00632322115356869 0.0496936558564956 PRKDC/SOX4/RPL26/MDM2/CDKN1A 5 GO:0060148 positive regulation of posttranscriptional gene silencing 5/725 31/18722 0.00632322115356869 0.0496936558564956 EGFR/DDX5/PUM1/TNRC6B/AGO2 5 GO:0071711 basement membrane organization 5/725 31/18722 0.00632322115356869 0.0496936558564956 CAV1/ITGB1/DAG1/LAMB1/PHLDB2 5 GO:0070661 leukocyte proliferation 22/725 318/18722 0.00643339630175987 0.0504812474514254 IGF2/DLG5/CD46/MIF/TFRC/SLC39A10/HSPD1/RPS6/ANXA1/PNP/IL6ST/BCL2/CEBPB/DLG1/CD55/PURA/CDKN1A/HES1/RIPK2/HMGB1/ARG2/CBLB 22 GO:0005977 glycogen metabolic process 8/725 72/18722 0.0065554947100807 0.0510395915745826 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/HMGB1 8 GO:0003159 morphogenesis of an endothelium 4/725 20/18722 0.00658377398932982 0.0510395915745826 RBPJ/RHOA/CSNK2B/RHOB 4 GO:0006346 DNA methylation-dependent heterochromatin assembly 4/725 20/18722 0.00658377398932982 0.0510395915745826 MPHOSPH8/DNMT3A/DNMT1/MBD3 4 GO:0007097 nuclear migration 4/725 20/18722 0.00658377398932982 0.0510395915745826 SYNE2/DYNC1H1/HOOK3/CDC42 4 GO:0010523 negative regulation of calcium ion transport into cytosol 4/725 20/18722 0.00658377398932982 0.0510395915745826 CALM1/BCL2/SRI/GSTO1 4 GO:0061154 endothelial tube morphogenesis 4/725 20/18722 0.00658377398932982 0.0510395915745826 RBPJ/RHOA/CSNK2B/RHOB 4 GO:0071243 cellular response to arsenic-containing substance 4/725 20/18722 0.00658377398932982 0.0510395915745826 DHX36/HNRNPA1/ATF3/GSTO1 4 GO:0071331 cellular response to hexose stimulus 13/725 153/18722 0.00658951020340013 0.0510395915745826 DYNLL1/LRP1/KIF5B/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 13 GO:0007272 ensheathment of neurons 12/725 136/18722 0.00661531104054069 0.0510395915745826 ITGB4/DAG1/CTSC/NF1/JAM3/DICER1/AFG3L2/PLEC/DLG1/CMTM8/QKI/EPB41L3 12 GO:0008366 axon ensheathment 12/725 136/18722 0.00661531104054069 0.0510395915745826 ITGB4/DAG1/CTSC/NF1/JAM3/DICER1/AFG3L2/PLEC/DLG1/CMTM8/QKI/EPB41L3 12 GO:0045727 positive regulation of translation 12/725 136/18722 0.00661531104054069 0.0510395915745826 PKM/PRKDC/SOX4/RPL26/RHOA/NPM1/DHX36/LARP1/PPP1R15A/AGO2/EIF5A/SERP1 12 GO:0021762 substantia nigra development 6/725 44/18722 0.00665160822041918 0.051086366771674 DYNLL1/BASP1/CALM1/RHOA/HSPA5/CDC42 6 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 6/725 44/18722 0.00665160822041918 0.051086366771674 CAV1/PUM1/HSPA1A/RTN4/HMGB1/CYBA 6 GO:1903573 negative regulation of response to endoplasmic reticulum stress 6/725 44/18722 0.00665160822041918 0.051086366771674 HSPA5/HERPUD1/HSPA1A/UFL1/PPP1R15A/GRINA 6 GO:1901214 regulation of neuron death 22/725 319/18722 0.00666669254777166 0.0511247572233805 LRP1/FOS/JUN/DHCR24/HSPD1/BTG2/ISL1/PARP1/GRN/RHOA/NF1/BCL2/LGMN/CEBPB/GHR/SERPINF1/CDC42/CPEB4/HRAS/TFAP2A/RASA1/DDIT3 22 GO:0007249 I-kappaB kinase/NF-kappaB signaling 20/725 281/18722 0.00674622467925263 0.051656514953371 GAPDH/WLS/BRD4/TFRC/HACD3/GJA1/RHOA/HSPB1/ASH1L/DHX36/ROCK1/USP10/TLE1/UFL1/ERC1/SLC20A1/NEK6/TMED4/CFLAR/RIPK2 20 GO:0050769 positive regulation of neurogenesis 17/725 225/18722 0.00677624339292012 0.0518081112499428 SPINT1/LRP1/CUX1/LRP2/DAG1/EGFR/NEURL1/MACF1/GOLGA4/GLI3/IL6ST/DHX36/DICER1/UFL1/SERPINF1/HES1/RAB11A 17 GO:0030833 regulation of actin filament polymerization 14/725 171/18722 0.0067885363011039 0.0518239314914091 IQGAP2/KANK1/ARHGAP18/TRIOBP/TMSB4X/RHOA/PPP1R9A/WASF2/DLG1/ARPC3/PFN1/RASA1/ARF1/CAPZB 14 GO:0035904 aorta development 7/725 58/18722 0.00686148082826532 0.0521451968792757 ADAMTS6/LRP1/LRP2/RBPJ/SOX4/HES1/ENG 7 GO:0043525 positive regulation of neuron apoptotic process 7/725 58/18722 0.00686148082826532 0.0521451968792757 JUN/GRN/RHOA/NF1/CDC42/TFAP2A/DDIT3 7 GO:0086065 cell communication involved in cardiac conduction 7/725 58/18722 0.00686148082826532 0.0521451968792757 CAV1/GJA1/CALM1/DSG2/GJA5/DSC2/SRI 7 GO:0030218 erythrocyte differentiation 11/725 120/18722 0.00690275284544714 0.0523020241757422 TGFBR3/PRKDC/RPS6/RPS19/HSPA1A/UFL1/UBA5/RCOR1/FAM210B/INHA/B2M 11 GO:0048675 axon extension 11/725 120/18722 0.00690275284544714 0.0523020241757422 NRP2/ITGB1/LRP1/SEMA6D/SEMA6A/MACF1/GOLGA4/USP9X/SEMA4C/RAB11A/RTN4 11 GO:0016052 carbohydrate catabolic process 13/725 154/18722 0.0069503743021603 0.0525058827684807 GAPDH/LDHA/ALDOA/TPI1/APP/AGL/PKM/GAA/LRP5/ENO1/FUT8/MANBA/HMGB1 13 GO:0071326 cellular response to monosaccharide stimulus 13/725 154/18722 0.0069503743021603 0.0525058827684807 DYNLL1/LRP1/KIF5B/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 13 GO:0046634 regulation of alpha-beta T cell activation 10/725 104/18722 0.00704866112515492 0.0530901385489009 ANXA1/PNP/GLI3/RHOA/SOCS1/CD55/RIPK2/HMGB1/ARG2/CBLB 10 GO:1903076 regulation of protein localization to plasma membrane 10/725 104/18722 0.00704866112515492 0.0530901385489009 ITGB1/LRP1/KIF5B/EGFR/EZR/CLTC/GOPC/DLG1/RAB11A/TMBIM1 10 GO:0006073 cellular glucan metabolic process 8/725 73/18722 0.00711937805532076 0.0533848037905635 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/HMGB1 8 GO:0035924 cellular response to vascular endothelial growth factor stimulus 8/725 73/18722 0.00711937805532076 0.0533848037905635 NRP2/CD63/SEMA6A/ANXA1/PGF/HSPB1/FLT1/PIK3CB 8 GO:0044042 glucan metabolic process 8/725 73/18722 0.00711937805532076 0.0533848037905635 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/HMGB1 8 GO:0010644 cell communication by electrical coupling 5/725 32/18722 0.00726010202409523 0.0540733238398395 CAV1/GJA1/CALM1/GJA5/SRI 5 GO:0014044 Schwann cell development 5/725 32/18722 0.00726010202409523 0.0540733238398395 ITGB4/DAG1/NF1/DICER1/PLEC 5 GO:0035767 endothelial cell chemotaxis 5/725 32/18722 0.00726010202409523 0.0540733238398395 MET/TMSB4X/HSPB1/LGMN/HMGB1 5 GO:1901532 regulation of hematopoietic progenitor cell differentiation 5/725 32/18722 0.00726010202409523 0.0540733238398395 PRKDC/NFE2L2/N4BP2L2/DHX36/HES1 5 GO:0015833 peptide transport 19/725 264/18722 0.00726863474091745 0.0540733238398395 DYNLL1/LRP1/KIF5B/EGFR/GJA1/ANXA1/ISL1/SOX4/LRP5/GLUL/CAMK2G/SYT7/HMGN3/MPC2/SRI/SERP1/RAB1A/PHPT1/RAC1 19 GO:0044262 cellular carbohydrate metabolic process 20/725 283/18722 0.00727520356259036 0.0540733238398395 TPI1/IGF2/UGP2/PMAIP1/AGL/AKR1B1/ISYNA1/DDB1/GAA/PHLDA2/IDH1/PHKB/IL6ST/B3GNT2/SLC35B4/NAGK/RANBP2/C1QTNF1/NCOA2/HMGB1 20 GO:0001838 embryonic epithelial tube formation 11/725 121/18722 0.00733579126518241 0.0544438154073348 SPINT1/LRP2/SOX4/BMP7/COBL/MIB1/IRX2/PFN1/BRD2/SETD2/SEMA4C 11 GO:0007411 axon guidance 17/725 227/18722 0.00737909271433323 0.0546851183756654 NRP2/RPL24/LRP1/SEMA6D/APP/DAG1/SEMA6A/KIF5B/EPHB4/LAMA5/ISL1/GLI3/MYCBP2/BMP7/B3GNT2/SEMA4C/RAC1 17 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 12/725 138/18722 0.00740872519487859 0.0548245664421015 CAV1/ARRDC3/RPS2/PDCD6/PTTG1IP/SKP1/NPM1/MYCBP2/HSPA5/HUWE1/RIPK2/CBLB 12 GO:0003197 endocardial cushion development 6/725 45/18722 0.00742945779927163 0.0548978448753759 TBX3/ISL1/RBPJ/BMP7/MDM2/ENG 6 GO:1902905 positive regulation of supramolecular fiber organization 16/725 209/18722 0.00749850027108558 0.0549701499666095 IQGAP2/AKAP9/APP/CLIP1/MET/RHOA/WASF2/HSPA1A/DLG1/ARPC3/PFN1/MTSS1/CDC42/NUMA1/RAC1/ARF1 16 GO:0072659 protein localization to plasma membrane 20/725 284/18722 0.00755208293817791 0.0549701499666095 ITGB1/LRP1/KRT18/KIF5B/EGFR/CDH1/LAMA5/MACF1/GOLGA4/EZR/ROCK1/CLTC/ARL6IP5/TMEM150A/GOPC/DLG1/EPB41L3/VAMP2/RAB11A/TMBIM1 20 GO:0001731 formation of translation preinitiation complex 3/725 11/18722 0.00755853117512859 0.0549701499666095 EIF4H/RPL13A/EIF2S2 3 GO:0003093 regulation of glomerular filtration 3/725 11/18722 0.00755853117512859 0.0549701499666095 GJA1/GJA5/CYBA 3 GO:0003139 secondary heart field specification 3/725 11/18722 0.00755853117512859 0.0549701499666095 LRP2/ISL1/RBPJ 3 GO:0051657 maintenance of organelle location 3/725 11/18722 0.00755853117512859 0.0549701499666095 AKAP9/GPSM2/UVRAG 3 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 3/725 11/18722 0.00755853117512859 0.0549701499666095 CALM1/SRI/GSTO1 3 GO:0072697 protein localization to cell cortex 3/725 11/18722 0.00755853117512859 0.0549701499666095 EZR/GPSM2/NUMA1 3 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 3/725 11/18722 0.00755853117512859 0.0549701499666095 NFE2L2/N4BP2L2/HES1 3 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 3/725 11/18722 0.00755853117512859 0.0549701499666095 CAV1/CALM1/SRI 3 GO:1903961 positive regulation of anion transmembrane transport 3/725 11/18722 0.00755853117512859 0.0549701499666095 TCAF1/ITGB1/ABCB1 3 GO:0097485 neuron projection guidance 17/725 228/18722 0.00769632366274785 0.0557379742612204 NRP2/RPL24/LRP1/SEMA6D/APP/DAG1/SEMA6A/KIF5B/EPHB4/LAMA5/ISL1/GLI3/MYCBP2/BMP7/B3GNT2/SEMA4C/RAC1 17 GO:0046631 alpha-beta T cell activation 13/725 156/18722 0.00771901854607793 0.0557379742612204 ANXA1/PNP/GLI3/CTSL/RHOA/SOCS1/BCL2/RPL22/CD55/RIPK2/HMGB1/ARG2/CBLB 13 GO:0007040 lysosome organization 8/725 74/18722 0.00771908816953575 0.0557379742612204 GAA/GRN/HOOK3/TFEB/ATP6AP2/SYT7/ARF1/ARL8B 8 GO:0048844 artery morphogenesis 8/725 74/18722 0.00771908816953575 0.0557379742612204 LRP1/LRP2/RBPJ/SOX4/NF1/GJA5/HES1/ENG 8 GO:0080171 lytic vacuole organization 8/725 74/18722 0.00771908816953575 0.0557379742612204 GAA/GRN/HOOK3/TFEB/ATP6AP2/SYT7/ARF1/ARL8B 8 GO:0051960 regulation of nervous system development 28/725 443/18722 0.00785299705566971 0.0565526711607872 SPINT1/LRP1/DLG5/CUX1/SEMA6D/LRP2/DAG1/SEMA6A/CTSC/EGFR/NEURL1/MACF1/GOLGA4/GLI3/IL6ST/NF1/BMP7/HOOK3/DHX36/DICER1/UFL1/DLG1/SERPINF1/HES1/SEMA4C/RAB11A/RTN4/B2M 28 GO:0071498 cellular response to fluid shear stress 4/725 21/18722 0.00788769747695336 0.0565526711607872 TFPI2/NFE2L2/PLEC/MTSS1 4 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 4/725 21/18722 0.00788769747695336 0.0565526711607872 MIF/PTTG1IP/BCL2/MDM2 4 GO:1902307 positive regulation of sodium ion transmembrane transport 4/725 21/18722 0.00788769747695336 0.0565526711607872 KIF5B/SLC9A1/ARF1/GLRX 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/725 21/18722 0.00788769747695336 0.0565526711607872 SPINT1/BTG2/NF1/SLC6A4 4 GO:0033157 regulation of intracellular protein transport 17/725 229/18722 0.0080244355541768 0.0571648807297557 TCAF1/KIF5B/CDH1/STOM/LMAN1/GLI3/BNIP3L/OAZ1/NMT1/PTPN14/B3GAT3/MDM2/HUWE1/CDC42/HRAS/VAMP2/UBE2D3 17 GO:0006766 vitamin metabolic process 10/725 106/18722 0.00803345049413358 0.0571648807297557 LRP2/CYP11A1/SLC19A3/SLC52A3/MTR/RDH10/LGMN/SLC52A1/RFK/GSTO1 10 GO:0046620 regulation of organ growth 10/725 106/18722 0.00803345049413358 0.0571648807297557 IGF2/BASP1/TGFBR3/GJA1/DUSP6/RBPJ/SLC6A4/DUSP9/LATS2/SERP1 10 GO:0030901 midbrain development 9/725 90/18722 0.00805202699566888 0.0571648807297557 DYNLL1/WLS/DLG5/BASP1/CALM1/RHOA/HSPA5/CDC42/HES1 9 GO:0035304 regulation of protein dephosphorylation 9/725 90/18722 0.00805202699566888 0.0571648807297557 SLC39A10/CALM1/HSP90B1/CSNK2B/ROCK1/BOD1L1/PPP6R2/PPP1R15A/PPIA 9 GO:0046849 bone remodeling 9/725 90/18722 0.00805202699566888 0.0571648807297557 LGR4/TFRC/EGFR/GJA1/LRP5/NF1/SUCO/SYT7/RAC1 9 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 9/725 90/18722 0.00805202699566888 0.0571648807297557 JUN/GJA1/PDCD4/GNA12/RHOA/ADAMTS1/MDM2/CDKN1A/DNMT1 9 GO:0033002 muscle cell proliferation 18/725 248/18722 0.00812759016503562 0.0576206357294623 JUN/AKR1B1/TGFBR3/IGFBP3/PRKDC/SF1/EGFR/GJA1/PDCD4/RBPJ/GNA12/RHOA/ADAMTS1/MDM2/CDKN1A/DNMT1/CFLAR/CYBA 18 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 7/725 60/18722 0.00824924600845798 0.0581483268465309 DDX5/SAP18/RBM25/TRA2B/HNRNPA1/DDX17/SRSF6 7 GO:0031638 zymogen activation 7/725 60/18722 0.00824924600845798 0.0581483268465309 DHCR24/CTSL/ENO1/LGMN/ASPH/RIPK2/SERPINE1 7 GO:0022900 electron transport chain 14/725 175/18722 0.00826246810476945 0.0581483268465309 AKR1B1/DHRS2/GLDC/PLEC/COX6A1/ADH5/ASPH/CYB5A/UQCRH/CHCHD2/SDHA/CYP19A1/FDX1/CYBA 14 GO:0050919 negative chemotaxis 6/725 46/18722 0.00827085098764031 0.0581483268465309 NRP2/SEMA6D/ITGAV/SEMA6A/RHOA/SEMA4C 6 GO:0055010 ventricular cardiac muscle tissue morphogenesis 6/725 46/18722 0.00827085098764031 0.0581483268465309 LRP2/TGFBR3/ISL1/RBPJ/LY6E/ENG 6 GO:0060976 coronary vasculature development 6/725 46/18722 0.00827085098764031 0.0581483268465309 ADAMTS6/LRP2/TGFBR3/GPC3/APELA/SETD2 6 GO:0048048 embryonic eye morphogenesis 5/725 33/18722 0.00828957534020699 0.0581992484757745 FBN1/FBN2/EFEMP1/BMP7/TFAP2A 5 GO:0045786 negative regulation of cell cycle 25/725 385/18722 0.00842276101478841 0.0590525250123962 PRKDC/DUSP1/EGFR/CTDSPL/BTG3/NR2F2/BTG2/PDCD4/SOX4/RPL26/NPM1/BMP7/ATRX/BRD7/PPP1R10/LATS2/BCL2/DLG1/MDM2/RHOB/INHA/CDKN1A/CDKN1C/CENPF/TIMP2 25 GO:0005976 polysaccharide metabolic process 10/725 107/18722 0.00856391363938873 0.0599592240857202 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/B3GNT2/CLTC/HMGB1 10 GO:1990874 vascular associated smooth muscle cell proliferation 9/725 91/18722 0.00863819201669413 0.0603958556312035 JUN/GJA1/PDCD4/GNA12/RHOA/ADAMTS1/MDM2/CDKN1A/DNMT1 9 GO:0071384 cellular response to corticosteroid stimulus 7/725 61/18722 0.00901576435368135 0.0628623239460946 ATP2B1/EGFR/ANXA1/ISL1/NR3C1/SERPINF1/CFLAR 7 GO:0090342 regulation of cell aging 7/725 61/18722 0.00901576435368135 0.0628623239460946 MIF/PRKDC/YPEL3/NEK6/ARG2/B2M/YBX1 7 GO:0086001 cardiac muscle cell action potential 8/725 76/18722 0.00903143869179989 0.0628851136383704 AKAP9/CAV1/GJA1/CALM1/DSG2/GJA5/DLG1/DSC2 8 GO:0051302 regulation of cell division 14/725 177/18722 0.00908880683848658 0.0631977529002585 IGF2/CALM1/PGF/TXNIP/RHOA/NCOA3/PKN2/CAT/BIRC6/CDC42/UVRAG/SETD2/RAB11A/YBX1 14 GO:0050729 positive regulation of inflammatory response 12/725 142/18722 0.00921854820171211 0.0639245155054428 NEAT1/APP/S100A9/HSPD1/CTSC/EGFR/PDCD4/GRN/IL6ST/RPS19/CEBPB/SERPINE1 12 GO:2000045 regulation of G1/S transition of mitotic cell cycle 12/725 142/18722 0.00921854820171211 0.0639245155054428 PRKDC/EGFR/CTDSPL/ANXA1/SOX4/RPL26/ADAMTS1/BRD7/BCL2/DLG1/MDM2/CDKN1A 12 GO:0002320 lymphoid progenitor cell differentiation 4/725 22/18722 0.00935029136812048 0.0642230717411961 PRKDC/SOX4/BCL2/HES1 4 GO:0034629 cellular protein-containing complex localization 4/725 22/18722 0.00935029136812048 0.0642230717411961 AKAP9/EZR/DLG1/RALB 4 GO:0048169 regulation of long-term neuronal synaptic plasticity 4/725 22/18722 0.00935029136812048 0.0642230717411961 APP/NEURL1/HRAS/RAB11A 4 GO:0060563 neuroepithelial cell differentiation 4/725 22/18722 0.00935029136812048 0.0642230717411961 SOX4/CEBPB/HES1/SERPINE1 4 GO:0071359 cellular response to dsRNA 4/725 22/18722 0.00935029136812048 0.0642230717411961 CAV1/NPM1/COLEC12/RALB 4 GO:0099563 modification of synaptic structure 4/725 22/18722 0.00935029136812048 0.0642230717411961 MYH10/RHOA/PFN1/CDC42 4 GO:0140467 integrated stress response signaling 4/725 22/18722 0.00935029136812048 0.0642230717411961 NFE2L2/HSPA5/PPP1R15A/DDIT3 4 GO:0034504 protein localization to nucleus 20/725 290/18722 0.00939857654874041 0.0642385822611291 TFRC/MAGED1/CDH1/PARP1/TXNIP/PTTG1IP/GLI3/SKP1/GLUL/NPM1/BMP7/PPP1R10/LATS2/MDM2/TNPO1/RANBP2/KPNB1/CDKN1A/CHCHD10/CBLB 20 GO:0050863 regulation of T cell activation 22/725 329/18722 0.00940427671478807 0.0642385822611291 CAV1/IGF2/DLG5/CD46/TFRC/HSPD1/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/B2M/CBLB 22 GO:0002183 cytoplasmic translational initiation 5/725 34/18722 0.00941591371474037 0.0642385822611291 EIF4H/RPL13A/EIF2S2/EIF3H/EIF3I 5 GO:0007431 salivary gland development 5/725 34/18722 0.00941591371474037 0.0642385822611291 DAG1/LAMA5/BMP7/TFCP2L1/CDC42 5 GO:0035909 aorta morphogenesis 5/725 34/18722 0.00941591371474037 0.0642385822611291 LRP1/RBPJ/SOX4/HES1/ENG 5 GO:0035637 multicellular organismal signaling 13/725 160/18722 0.00945671520936727 0.0644013690631819 ATP2B1/AKAP9/CAV1/GJA1/CALM1/ISL1/JAM3/DSG2/GJA5/PLEC/SLC9A1/DSC2/SRI 13 GO:0043393 regulation of protein binding 15/725 196/18722 0.00946518444507211 0.0644013690631819 CAV1/LRP1/APP/TGFBR3/PHLDA2/LRPAP1/ROCK1/PTPRF/RALB/CDC42/HOPX/CDKN1A/RIPK2/B2M/CBLB 15 GO:0006325 chromatin organization 26/725 409/18722 0.00948692953593007 0.0644627960021844 BRD4/CBX4/NASP/MPHOSPH8/DNMT3A/NPM1/BPTF/HMG20B/ATRX/HP1BP3/GPX4/RERE/NR3C1/KDM5A/DEK/HMGN3/BRD2/TDG/BAZ1B/KDM5B/DNMT1/SETD2/CHD4/HMGB1/MBD3/SMARCA1 26 GO:0000380 alternative mRNA splicing, via spliceosome 8/725 77/18722 0.00974680601551951 0.0658729876832447 DDX5/SAP18/RBM25/SRSF9/TRA2B/HNRNPA1/DDX17/SRSF6 8 GO:0048644 muscle organ morphogenesis 8/725 77/18722 0.00974680601551951 0.0658729876832447 LRP2/TGFBR3/ISL1/RBPJ/ARID5B/LY6E/SERP1/ENG 8 GO:0002328 pro-B cell differentiation 3/725 12/18722 0.00979114785217212 0.0658729876832447 PRKDC/SOX4/HES1 3 GO:0006703 estrogen biosynthetic process 3/725 12/18722 0.00979114785217212 0.0658729876832447 HSD3B1/HSD17B1/CYP19A1 3 GO:0009886 post-embryonic animal morphogenesis 3/725 12/18722 0.00979114785217212 0.0658729876832447 FBN1/EFEMP1/ATRX 3 GO:0034333 adherens junction assembly 3/725 12/18722 0.00979114785217212 0.0658729876832447 DLG5/JAM3/ZNF703 3 GO:0060019 radial glial cell differentiation 3/725 12/18722 0.00979114785217212 0.0658729876832447 GLI3/RHOA/HES1 3 GO:0032874 positive regulation of stress-activated MAPK cascade 11/725 126/18722 0.00982755998007926 0.0658729876832447 MAP3K4/APP/GADD45B/ARL6IP5/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/SDCBP 11 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 7/725 62/18722 0.00983319298097786 0.0658729876832447 LRP1/BMP7/CSNK2B/INHA/GDF15/ENG/SDCBP 7 GO:1903078 positive regulation of protein localization to plasma membrane 7/725 62/18722 0.00983319298097786 0.0658729876832447 ITGB1/LRP1/KIF5B/EGFR/EZR/DLG1/RAB11A 7 GO:0060560 developmental growth involved in morphogenesis 17/725 234/18722 0.00983741402174319 0.0658729876832447 NRP2/ITGB1/LRP1/SEMA6D/APP/SEMA6A/MACF1/GOLGA4/COBL/SPAG9/RDH10/IQGAP1/KDM5B/USP9X/SEMA4C/RAB11A/RTN4 17 GO:0090398 cellular senescence 9/725 93/18722 0.00990696379874094 0.0661638992039761 PRKDC/TBX3/YPEL3/HRAS/NEK6/CDKN1A/ARG2/B2M/YBX1 9 GO:1902807 negative regulation of cell cycle G1/S phase transition 9/725 93/18722 0.00990696379874094 0.0661638992039761 PRKDC/CTDSPL/SOX4/RPL26/BRD7/BCL2/DLG1/MDM2/CDKN1A 9 GO:1905710 positive regulation of membrane permeability 6/725 48/18722 0.0101551186949185 0.0677319692954501 JAM3/BNIP3L/NMT1/HSPA1A/SLC9A1/CHCHD10 6 GO:0003014 renal system process 10/725 110/18722 0.0103174156652397 0.0687240210342971 AKR1B1/GJA1/RHOA/GJA5/BCL2/LGMN/CLDN4/MAGED2/SGK1/CYBA 10 GO:0035270 endocrine system development 11/725 127/18722 0.0103958789621954 0.0691557880044203 CDH1/ANXA1/ISL1/RBPJ/FSTL3/SOX4/PBX1/NF1/ARID5B/LY6E/HES1 11 GO:0034250 positive regulation of cellular amide metabolic process 13/725 162/18722 0.010433181787539 0.0693129731075165 PKM/PRKDC/NFE2L2/SOX4/RPL26/RHOA/NPM1/DHX36/LARP1/PPP1R15A/AGO2/EIF5A/SERP1 13 GO:0010721 negative regulation of cell development 14/725 180/18722 0.0104489475616716 0.0693268523430802 FBN1/FBLN1/KANK1/SEMA6D/SEMA6A/NF1/BMP7/HOOK3/DICER1/HES1/TACSTD2/SEMA4C/RTN4/B2M 14 GO:0090559 regulation of membrane permeability 8/725 78/18722 0.0105034494007493 0.069597366029279 PMAIP1/JAM3/BNIP3L/NMT1/BCL2/HSPA1A/SLC9A1/CHCHD10 8 GO:0034405 response to fluid shear stress 5/725 35/18722 0.0106432496684057 0.0699748801156273 GJA1/TFPI2/NFE2L2/PLEC/MTSS1 5 GO:0035633 maintenance of blood-brain barrier 5/725 35/18722 0.0106432496684057 0.0699748801156273 ITGB1/LAMC1/GJA1/JAM3/ACTG1 5 GO:0040001 establishment of mitotic spindle localization 5/725 35/18722 0.0106432496684057 0.0699748801156273 ITGB1/GJA1/GPSM2/KPNB1/NUMA1 5 GO:0045454 cell redox homeostasis 5/725 35/18722 0.0106432496684057 0.0699748801156273 PRDX6/NFE2L2/ERO1A/TXNRD1/DDIT3 5 GO:0045907 positive regulation of vasoconstriction 5/725 35/18722 0.0106432496684057 0.0699748801156273 CAV1/EGFR/GJA1/RHOA/GJA5 5 GO:1905898 positive regulation of response to endoplasmic reticulum stress 5/725 35/18722 0.0106432496684057 0.0699748801156273 CAV1/PMAIP1/NFE2L2/HERPUD1/DDIT3 5 GO:0016239 positive regulation of macroautophagy 7/725 63/18722 0.0107033802366806 0.0701881428457105 BNIP3L/LARP1/HSPB8/RALB/UVRAG/PIP4K2A/RIPK2 7 GO:0046902 regulation of mitochondrial membrane permeability 7/725 63/18722 0.0107033802366806 0.0701881428457105 PMAIP1/BNIP3L/NMT1/BCL2/HSPA1A/SLC9A1/CHCHD10 7 GO:0043524 negative regulation of neuron apoptotic process 12/725 145/18722 0.0107883172917894 0.0706537213851172 LRP1/HSPD1/BTG2/ISL1/GRN/RHOA/BCL2/LGMN/CEBPB/CPEB4/HRAS/RASA1 12 GO:0043270 positive regulation of ion transport 19/725 275/18722 0.0109708607654071 0.071506639808906 TCAF1/ATP2B1/AKAP9/CAV1/ITGB1/KIF5B/KCNN4/CALM1/TMSB4X/ABCB1/SLC6A4/HOMER1/CEBPB/SLC9A1/DLG1/SRI/ARF1/GLRX/GSTO1 19 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 4/725 23/18722 0.0109785251495009 0.071506639808906 ENPEP/RHOA/ATP6AP2/CYBA 4 GO:0003283 atrial septum development 4/725 23/18722 0.0109785251495009 0.071506639808906 ISL1/SOX4/GJA5/MDM2 4 GO:0060396 growth hormone receptor signaling pathway 4/725 23/18722 0.0109785251495009 0.071506639808906 CSH1/LEPROTL1/GHR/GDF15 4 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11/725 128/18722 0.0109890851077407 0.071506639808906 MAP3K4/APP/GADD45B/ARL6IP5/CDC42/SASH1/HRAS/SEMA4C/RIPK2/HMGB1/SDCBP 11 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 6/725 49/18722 0.0112033117422911 0.0727139401045753 BMP7/CSNK2B/INHA/GDF15/ENG/SDCBP 6 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 6/725 49/18722 0.0112033117422911 0.0727139401045753 PMAIP1/CFLAR/SERPINE1/TMBIM1/ATF3/TIMP3 6 GO:0034764 positive regulation of transmembrane transport 16/725 219/18722 0.0114464009803442 0.0741966835925383 TCAF1/AKAP9/ITGB1/KIF5B/KCNN4/CALM1/TMSB4X/NFE2L2/ABCB1/OPN3/GPC3/SLC9A1/SRI/ARF1/GLRX/GSTO1 16 GO:0034101 erythrocyte homeostasis 11/725 129/18722 0.0116078537432132 0.074811277737795 TGFBR3/PRKDC/RPS6/RPS19/HSPA1A/UFL1/UBA5/RCOR1/FAM210B/INHA/B2M 11 GO:0006749 glutathione metabolic process 7/725 64/18722 0.0116281565423038 0.074811277737795 CLIC3/NFE2L2/IDH1/GPX4/ARL6IP5/CLIC1/GSTO1 7 GO:0032507 maintenance of protein location in cell 7/725 64/18722 0.0116281565423038 0.074811277737795 CAV1/GJA1/TMSB4X/SKP1/HSPA5/KDELR2/CHCHD10 7 GO:0048857 neural nucleus development 7/725 64/18722 0.0116281565423038 0.074811277737795 DYNLL1/BASP1/CALM1/RHOA/HSPA5/BCL2/CDC42 7 GO:0046632 alpha-beta T cell differentiation 10/725 112/18722 0.0116297665925 0.074811277737795 ANXA1/PNP/GLI3/CTSL/RHOA/SOCS1/BCL2/RPL22/RIPK2/HMGB1 10 GO:1901222 regulation of NIK/NF-kappaB signaling 10/725 112/18722 0.0116297665925 0.074811277737795 APP/EGFR/PDCD4/TMSB4X/RHOA/BMP7/TRIM44/NFAT5/SASH1/HMGB1 10 GO:0097529 myeloid leukocyte migration 16/725 220/18722 0.0119173511281386 0.0765640720767232 CSF3R/MIF/S100A9/DUSP1/ANXA1/PGF/RPS19/JAM3/PDE4B/LGMN/HMGB1/CD99/SERPINE1/RAC1/FLT1/PPIA 16 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 5/725 36/18722 0.0119755612077072 0.0766466158609439 CTSL/CTSV/LGMN/ARL8B/B2M 5 GO:0003230 cardiac atrium development 5/725 36/18722 0.0119755612077072 0.0766466158609439 ISL1/SOX4/GJA5/MDM2/ENG 5 GO:1903539 protein localization to postsynaptic membrane 5/725 36/18722 0.0119755612077072 0.0766466158609439 DAG1/DLG1/HRAS/VAMP2/RAB11A 5 GO:0044264 cellular polysaccharide metabolic process 9/725 96/18722 0.0120668586744399 0.0771335518546477 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/B3GNT2/HMGB1 9 GO:0032204 regulation of telomere maintenance 8/725 80/18722 0.0121459776145308 0.0772969532255818 MAP3K4/PARP1/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1 8 GO:0032386 regulation of intracellular transport 22/725 337/18722 0.0121961399652874 0.0772969532255818 TCAF1/KIF5B/CDH1/STOM/LMAN1/EZR/GLI3/DYNC1H1/BNIP3L/OAZ1/NMT1/PTPN14/B3GAT3/MDM2/HUWE1/CDC42/HRAS/NUMA1/SETD2/VAMP2/UBE2D3/ARF1 22 GO:1904062 regulation of cation transmembrane transport 23/725 357/18722 0.0122046418648548 0.0772969532255818 C4orf3/AKAP9/CAV1/ITGB1/FXYD3/UTRN/CD63/APP/KIF5B/KCNN4/STOM/CALM1/TMSB4X/PDE4B/HOMER1/SLC9A1/DLG1/VAMP2/SRI/ARF1/GLRX/GSTO1/CYBA 23 GO:0016051 carbohydrate biosynthetic process 15/725 202/18722 0.0122580679348435 0.0772969532255818 TPI1/IGF2/UGP2/AGL/AKR1B1/ISYNA1/DDB1/NANS/B3GNT2/CLTC/SLC35B4/FUT8/RANBP2/CHST12/ATF3 15 GO:0046638 positive regulation of alpha-beta T cell differentiation 6/725 50/18722 0.0123256707641333 0.0772969532255818 ANXA1/PNP/GLI3/RHOA/SOCS1/RIPK2 6 GO:0006983 ER overload response 3/725 13/18722 0.0123669025578905 0.0772969532255818 HSPA5/CCDC47/DDIT3 3 GO:0010917 negative regulation of mitochondrial membrane potential 3/725 13/18722 0.0123669025578905 0.0772969532255818 PMAIP1/BNIP3L/ARL6IP5 3 GO:0032429 regulation of phospholipase A2 activity 3/725 13/18722 0.0123669025578905 0.0772969532255818 LRP1/EGFR/ANXA1 3 GO:0036302 atrioventricular canal development 3/725 13/18722 0.0123669025578905 0.0772969532255818 TBX3/RBPJ/ENG 3 GO:0044090 positive regulation of vacuole organization 3/725 13/18722 0.0123669025578905 0.0772969532255818 GRN/RALB/PIP4K2A 3 GO:0044794 positive regulation by host of viral process 3/725 13/18722 0.0123669025578905 0.0772969532255818 HSPA8/STOM/CFL1 3 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 3/725 13/18722 0.0123669025578905 0.0772969532255818 CALM1/SRI/GSTO1 3 GO:0051451 myoblast migration 3/725 13/18722 0.0123669025578905 0.0772969532255818 ANXA1/ROCK1/NET1 3 GO:0051481 negative regulation of cytosolic calcium ion concentration 3/725 13/18722 0.0123669025578905 0.0772969532255818 ATP2B1/LRP1/GTF2I 3 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/725 13/18722 0.0123669025578905 0.0772969532255818 BTG2/TNRC6B/AGO2 3 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 3/725 13/18722 0.0123669025578905 0.0772969532255818 RBPJ/NFE2L2/BACH1 3 GO:0098814 spontaneous synaptic transmission 3/725 13/18722 0.0123669025578905 0.0772969532255818 ITGB1/APP/PPP1R9A 3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/725 13/18722 0.0123669025578905 0.0772969532255818 PMAIP1/ATF3/TIMP3 3 GO:0035418 protein localization to synapse 7/725 65/18722 0.0126093305261586 0.0785217400947152 DAG1/KIF5B/HSPB1/DLG1/HRAS/VAMP2/RAB11A 7 GO:0048524 positive regulation of viral process 7/725 65/18722 0.0126093305261586 0.0785217400947152 HACD3/DDB1/STOM/P4HB/LARP1/PKN2/PPIA 7 GO:0048645 animal organ formation 7/725 65/18722 0.0126093305261586 0.0785217400947152 LRP2/ISL1/RBPJ/GLI3/BMP7/RDH10/HES1 7 GO:0003148 outflow tract septum morphogenesis 4/725 24/18722 0.0127787949478808 0.0788985524857585 NRP2/LRP2/ISL1/ENG 4 GO:0021801 cerebral cortex radial glia-guided migration 4/725 24/18722 0.0127787949478808 0.0788985524857585 ADGRG1/LAMB1/GLI3/RTN4 4 GO:0022030 telencephalon glial cell migration 4/725 24/18722 0.0127787949478808 0.0788985524857585 ADGRG1/LAMB1/GLI3/RTN4 4 GO:0051647 nucleus localization 4/725 24/18722 0.0127787949478808 0.0788985524857585 SYNE2/DYNC1H1/HOOK3/CDC42 4 GO:0071378 cellular response to growth hormone stimulus 4/725 24/18722 0.0127787949478808 0.0788985524857585 CSH1/LEPROTL1/GHR/GDF15 4 GO:2000209 regulation of anoikis 4/725 24/18722 0.0127787949478808 0.0788985524857585 CAV1/ITGB1/BCL2/TLE1 4 GO:2001026 regulation of endothelial cell chemotaxis 4/725 24/18722 0.0127787949478808 0.0788985524857585 MET/TMSB4X/HSPB1/LGMN 4 GO:1901990 regulation of mitotic cell cycle phase transition 20/725 299/18722 0.0128334984312318 0.0791399069925958 BRD4/APP/PRKDC/DUSP1/DDB1/EGFR/CTDSPL/ANXA1/SOX4/RPL26/PBX1/ADAMTS1/BRD7/BCL2/DLG1/MDM2/NEK6/CDKN1A/RAB11A/CENPF 20 GO:1901216 positive regulation of neuron death 9/725 97/18722 0.0128594475662198 0.0792035719479562 FOS/JUN/PARP1/GRN/RHOA/NF1/CDC42/TFAP2A/DDIT3 9 GO:0015931 nucleobase-containing compound transport 16/725 222/18722 0.0129048450793171 0.0793867229454593 GJA1/NCBP3/NPM1/SLC29A3/SLC25A36/IGF2BP3/SRSF7/SLC35B4/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A/YBX1 16 GO:0051052 regulation of DNA metabolic process 23/725 359/18722 0.0129727881372302 0.0797079552334788 MAP3K4/TFRC/FUS/PRKDC/DUSP1/EGFR/GJA1/PARP1/MPHOSPH8/NPM1/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/DEK/CDKN1A/SETD2/USP9X/HMGB1/SUB1/MBD3 23 GO:0048708 astrocyte differentiation 8/725 81/18722 0.0130345483232644 0.0799904666472487 LRP1/APP/S100A9/EGFR/GRN/IL6ST/NF1/HES1 8 GO:0034767 positive regulation of ion transmembrane transport 13/725 167/18722 0.0132185580027393 0.0810216088462945 TCAF1/AKAP9/ITGB1/KIF5B/KCNN4/CALM1/TMSB4X/ABCB1/SLC9A1/SRI/ARF1/GLRX/GSTO1 13 GO:1901888 regulation of cell junction assembly 15/725 204/18722 0.0133197689825117 0.0815433683240965 CAV1/LRP1/DLG5/APP/GJA1/MACF1/RHOA/PTPRA/PPP1R9A/ACTG1/ROCK1/SLC9A1/IQGAP1/PHLDB2/RAC1 15 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 21/725 320/18722 0.0133697033132448 0.0815456150527096 PRDX6/SON/RBM39/HSPA8/SF1/DDX5/SCAF11/SAP18/SRRM2/NPM1/RBM25/SRSF9/TRA2B/SRSF7/HNRNPA1/PNN/DDX17/QKI/SRSF6/SNU13/SNRPD2 21 GO:0000398 mRNA splicing, via spliceosome 21/725 320/18722 0.0133697033132448 0.0815456150527096 PRDX6/SON/RBM39/HSPA8/SF1/DDX5/SCAF11/SAP18/SRRM2/NPM1/RBM25/SRSF9/TRA2B/SRSF7/HNRNPA1/PNN/DDX17/QKI/SRSF6/SNU13/SNRPD2 21 GO:0030513 positive regulation of BMP signaling pathway 5/725 37/18722 0.013416658700722 0.0815456150527096 RBPJ/GPC3/HES1/NUMA1/ENG 5 GO:0033120 positive regulation of RNA splicing 5/725 37/18722 0.013416658700722 0.0815456150527096 PRDX6/HSPA8/TRA2B/HSPA1A/POLR2A 5 GO:0045730 respiratory burst 5/725 37/18722 0.013416658700722 0.0815456150527096 GRN/RPS19/CD55/RAC1/CYBA 5 GO:0062237 protein localization to postsynapse 5/725 37/18722 0.013416658700722 0.0815456150527096 DAG1/DLG1/HRAS/VAMP2/RAB11A 5 GO:0072175 epithelial tube formation 11/725 132/18722 0.0136243004422873 0.0827084777747954 SPINT1/LRP2/SOX4/BMP7/COBL/MIB1/IRX2/PFN1/BRD2/SETD2/SEMA4C 11 GO:0048880 sensory system development 24/725 381/18722 0.0136859848173016 0.0829835610513179 ATP2B1/FBN1/FBN2/TENM3/RPL24/SMOC1/EFEMP1/ISL1/GLI3/PBX1/LRP5/NF1/BMP7/RDH10/BCL2/DLG1/NIPBL/SERPINF1/C12orf57/TFAP2A/KDM5B/HMGB1/RDH13/FLT1 24 GO:0072594 establishment of protein localization to organelle 26/725 422/18722 0.0137539910623156 0.0832962732316341 HSPD1/HSPA8/CDH1/LMAN1/CALM1/TXNIP/PTTG1IP/GLI3/BNIP3L/HSPA5/SEC62/NMT1/PPP1R10/HERPUD1/NIPBL/TNPO1/RANBP2/KPNB1/HUWE1/CDKN1A/RAB11A/UBE2D3/SEC61B/DDIT3/SEC61G/CBLB 26 GO:1901989 positive regulation of cell cycle phase transition 10/725 115/18722 0.0138298670487062 0.0836080966844005 BRD4/APP/EGFR/ANXA1/PBX1/NPM1/ADAMTS1/PPP1R10/MDM2/RAB11A 10 GO:0099173 postsynapse organization 13/725 168/18722 0.013838467768438 0.0836080966844005 NRP2/HSPA8/PPP1R9A/HOMER1/DHX36/ACTG1/WASF2/LGMN/CFL1/DLG1/CDC42/ARF4/ARF1 13 GO:0016358 dendrite development 17/725 243/18722 0.0139103668286076 0.0839424398264428 ITGB1/DLG5/CUX1/APP/NEURL1/RHOA/PPP1R9A/BMP7/COBL/DHX36/CFL1/IQGAP1/RERE/BTBD3/CDC42/ARF4/ARF1 17 GO:0060395 SMAD protein signal transduction 8/725 82/18722 0.013969762369062 0.0842006247904579 LRP1/FOS/JUN/PARP1/BMP7/INHA/GDF15/SUB1 8 GO:0008064 regulation of actin polymerization or depolymerization 14/725 187/18722 0.014242466895533 0.0856406461369594 IQGAP2/KANK1/ARHGAP18/TRIOBP/TMSB4X/RHOA/PPP1R9A/WASF2/DLG1/ARPC3/PFN1/RASA1/ARF1/CAPZB 14 GO:0033044 regulation of chromosome organization 14/725 187/18722 0.014242466895533 0.0856406461369594 MAP3K4/DUSP1/PARP1/MPHOSPH8/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/NEK6/DNMT1/NUMA1/CENPF 14 GO:0003018 vascular process in circulatory system 18/725 263/18722 0.0142657389360347 0.0856789462876304 ATP2B1/CAV1/LRP1/LRP2/TFRC/SOD3/EGFR/ADRB1/GJA1/SLC16A12/SLC38A1/ABCB1/RHOA/SLC6A4/ROCK1/GJA5/PLEC/SLC7A5 18 GO:0006364 rRNA processing 16/725 225/18722 0.0145048355737247 0.0868170580589923 RPS21/RPL14/PRKDC/RPS6/RPS16/RPS8/RPS25/RPL26/RPS19/RPL10A/DDX17/RPL7A/RPL7/RPL27/SNU13/NOP10 16 GO:0010001 glial cell differentiation 16/725 225/18722 0.0145048355737247 0.0868170580589923 SPINT1/ITGB4/LRP1/APP/DAG1/S100A9/EGFR/GRN/SOX4/GLI3/IL6ST/RHOA/NF1/DICER1/PLEC/HES1 16 GO:0051146 striated muscle cell differentiation 19/725 283/18722 0.0145066183026172 0.0868170580589923 KRT19/KRT8/ITGB1/IGF2/ADAM12/TBX3/ISL1/RBPJ/HOMER1/SPAG9/ACTG1/BCL2/PLEC/SLC9A1/HOPX/GDF15/CFLAR/MORF4L2/YBX1 19 GO:2001236 regulation of extrinsic apoptotic signaling pathway 12/725 151/18722 0.0145394877664078 0.0869111597734921 CAV1/ITGAV/PMAIP1/ITGA6/BCL2/HSPA1A/BIRC6/CFLAR/SERPINE1/TMBIM1/ATF3/TIMP3 12 GO:0043200 response to amino acid 10/725 116/18722 0.0146282879166233 0.0870812318166133 NEURL1/DNMT3A/RHOA/SOCS1/CEBPB/SLC38A9/UFL1/CPEB4/DNMT1/CYBA 10 GO:0010517 regulation of phospholipase activity 7/725 67/18722 0.014747974429115 0.0870812318166133 LRP1/EGFR/ANXA1/GNAQ/HRAS/ARF4/FLT1 7 GO:0046635 positive regulation of alpha-beta T cell activation 7/725 67/18722 0.014747974429115 0.0870812318166133 ANXA1/PNP/GLI3/RHOA/SOCS1/CD55/RIPK2 7 GO:0070527 platelet aggregation 7/725 67/18722 0.014747974429115 0.0870812318166133 IL6ST/HSPB1/ACTG1/C1QTNF1/CLIC1/PIK3CB/PPIA 7 GO:1902117 positive regulation of organelle assembly 7/725 67/18722 0.014747974429115 0.0870812318166133 RHOA/DYNC1H1/GPSM2/RALB/PIP4K2A/NUMA1/SDCBP 7 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 4/725 25/18722 0.0147569102644448 0.0870812318166133 GJA1/RHOA/GJA5/CYBA 4 GO:0016540 protein autoprocessing 4/725 25/18722 0.0147569102644448 0.0870812318166133 PISD/PARP1/CTSL/AFG3L2 4 GO:0048143 astrocyte activation 4/725 25/18722 0.0147569102644448 0.0870812318166133 LRP1/APP/EGFR/GRN 4 GO:1904385 cellular response to angiotensin 4/725 25/18722 0.0147569102644448 0.0870812318166133 CAV1/NFE2L2/ROCK1/CYBA 4 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 4/725 25/18722 0.0147569102644448 0.0870812318166133 LRP1/ADAMTS1/MDM2/IQGAP1 4 GO:1905048 regulation of metallopeptidase activity 4/725 25/18722 0.0147569102644448 0.0870812318166133 LRP1/CLDN4/TIMP3/TIMP2 4 GO:0021545 cranial nerve development 6/725 52/18722 0.0148028989251034 0.0871497034278152 NRP2/RPL24/ISL1/GLI3/TFAP2A/HES1 6 GO:0072132 mesenchyme morphogenesis 6/725 52/18722 0.0148028989251034 0.0871497034278152 TBX3/ISL1/RBPJ/BMP7/MDM2/ENG 6 GO:0030832 regulation of actin filament length 14/725 188/18722 0.0148612832041412 0.0873919310461619 IQGAP2/KANK1/ARHGAP18/TRIOBP/TMSB4X/RHOA/PPP1R9A/WASF2/DLG1/ARPC3/PFN1/RASA1/ARF1/CAPZB 14 GO:0035136 forelimb morphogenesis 5/725 38/18722 0.0149701730398766 0.0878284804851096 TBX3/ATRX/RDH10/NIPBL/TFAP2A 5 GO:0071392 cellular response to estradiol stimulus 5/725 38/18722 0.0149701730398766 0.0878284804851096 EGFR/NCOA3/FAM210B/CFLAR/ZNF703 5 GO:0033674 positive regulation of kinase activity 28/725 467/18722 0.0151518489055993 0.0882947188109347 IGF2/MAP3K4/DAG1/EPHB4/MAGED1/EGFR/RPLP1/MET/NEURL1/CALM1/RHOA/PPP1R9A/NPM1/SOCS1/RAD50/GHR/DLG1/IQGAP1/RANBP2/RALB/CDC42/SASH1/HRAS/CDKN1A/ERP29/HMGB1/FLT1/PPIA 28 GO:0000375 RNA splicing, via transesterification reactions 21/725 324/18722 0.0151777713138735 0.0882947188109347 PRDX6/SON/RBM39/HSPA8/SF1/DDX5/SCAF11/SAP18/SRRM2/NPM1/RBM25/SRSF9/TRA2B/SRSF7/HNRNPA1/PNN/DDX17/QKI/SRSF6/SNU13/SNRPD2 21 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 3/725 14/18722 0.0152935022915764 0.0882947188109347 EZR/RAC1/PIK3CB 3 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 3/725 14/18722 0.0152935022915764 0.0882947188109347 FBLN1/KANK1/TACSTD2 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/725 14/18722 0.0152935022915764 0.0882947188109347 GJA1/HSPA5/KDELR2 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/725 14/18722 0.0152935022915764 0.0882947188109347 PMAIP1/DDX5/RPL26 3 GO:0045837 negative regulation of membrane potential 3/725 14/18722 0.0152935022915764 0.0882947188109347 PMAIP1/BNIP3L/ARL6IP5 3 GO:0051645 Golgi localization 3/725 14/18722 0.0152935022915764 0.0882947188109347 HOOK3/CDC42/UVRAG 3 GO:0060911 cardiac cell fate commitment 3/725 14/18722 0.0152935022915764 0.0882947188109347 TBX3/ISL1/RBPJ 3 GO:0071236 cellular response to antibiotic 3/725 14/18722 0.0152935022915764 0.0882947188109347 HSPA5/SLC9A1/MDM2 3 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 3/725 14/18722 0.0152935022915764 0.0882947188109347 FBLN1/KANK1/TACSTD2 3 GO:1902036 regulation of hematopoietic stem cell differentiation 3/725 14/18722 0.0152935022915764 0.0882947188109347 PRKDC/NFE2L2/N4BP2L2 3 GO:1904294 positive regulation of ERAD pathway 3/725 14/18722 0.0152935022915764 0.0882947188109347 CAV1/NFE2L2/HERPUD1 3 GO:1905049 negative regulation of metallopeptidase activity 3/725 14/18722 0.0152935022915764 0.0882947188109347 LRP1/TIMP3/TIMP2 3 GO:0050808 synapse organization 26/725 426/18722 0.0153393504452873 0.0884586659922198 NRP2/DLG5/MYH10/APP/DAG1/HSPA8/CDH1/NEURL1/RHOA/PPP1R9A/HOMER1/DHX36/ACTG1/WASF2/AFG3L2/LGMN/CFL1/DLG1/PFN1/ERC1/PTPRF/CDC42/ARF4/ARF1/CHCHD10/SDCBP 26 GO:0051225 spindle assembly 10/725 117/18722 0.0154606028561097 0.0890068272039575 RHOA/DYNC1H1/HSPA1A/GPSM2/KPNB1/STAG1/NEK6/NUMA1/RAB11A/CCSAP 10 GO:0045807 positive regulation of endocytosis 9/725 100/18722 0.0154695235286421 0.0890068272039575 LRP1/CD63/GPC3/MIB1/APELA/CDC42/SERPINE1/ARF1/B2M 9 GO:0032922 circadian regulation of gene expression 7/725 68/18722 0.0159089189916151 0.0912243329960375 LGR4/MAGED1/ZFHX3/MYCBP2/KDM5A/HUWE1/NCOA2 7 GO:0046637 regulation of alpha-beta T cell differentiation 7/725 68/18722 0.0159089189916151 0.0912243329960375 ANXA1/PNP/GLI3/RHOA/SOCS1/RIPK2/HMGB1 7 GO:0046686 response to cadmium ion 7/725 68/18722 0.0159089189916151 0.0912243329960375 FOS/JUN/EGFR/CAT/CYB5A/UBE2D3/B2M 7 GO:0006112 energy reserve metabolic process 8/725 84/18722 0.0159853527509507 0.0913525964989507 IGF2/UGP2/AGL/GAA/PHLDA2/PHKB/IL6ST/HMGB1 8 GO:0010921 regulation of phosphatase activity 8/725 84/18722 0.0159853527509507 0.0913525964989507 SLC39A10/CALM1/HSP90B1/CSNK2B/ROCK1/BOD1L1/PPP6R2/PPP1R15A 8 GO:0045445 myoblast differentiation 8/725 84/18722 0.0159853527509507 0.0913525964989507 IGFBP3/DDX5/TBX3/ISL1/RBPJ/PLEC/DDX17/DDIT3 8 GO:2000772 regulation of cellular senescence 6/725 53/18722 0.0161625983202477 0.0922614987447471 PRKDC/YPEL3/NEK6/ARG2/B2M/YBX1 6 GO:0001678 cellular glucose homeostasis 13/725 172/18722 0.0165435888646215 0.0940128385143119 DYNLL1/LRP1/KIF5B/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 13 GO:0007219 Notch signaling pathway 13/725 172/18722 0.0165435888646215 0.0940128385143119 KRT19/ANXA4/GALNT11/CD46/AAK1/APP/NEURL1/RBPJ/IL6ST/BMP7/MIB1/MAML3/HES1 13 GO:0042770 signal transduction in response to DNA damage 13/725 172/18722 0.0165435888646215 0.0940128385143119 MIF/PMAIP1/PRKDC/DDX5/SOX4/PTTG1IP/RPL26/NPM1/ATRX/PPP1R10/USP10/MDM2/CDKN1A 13 GO:1990138 neuron projection extension 13/725 172/18722 0.0165435888646215 0.0940128385143119 NRP2/ITGB1/LRP1/SEMA6D/SEMA6A/MACF1/GOLGA4/SPAG9/IQGAP1/USP9X/SEMA4C/RAB11A/RTN4 13 GO:0086091 regulation of heart rate by cardiac conduction 5/725 39/18722 0.0166395450731448 0.0944522440938084 AKAP9/CAV1/ISL1/DSG2/DSC2 5 GO:0003158 endothelium development 11/725 136/18722 0.0167117793472743 0.0946502899567972 GJA1/MET/NR2F2/RBPJ/EDF1/EZR/RHOA/CSNK2B/ROCK1/GJA5/RHOB 11 GO:0043401 steroid hormone mediated signaling pathway 11/725 136/18722 0.0167117793472743 0.0946502899567972 DDX5/ISL1/PARP1/RHOA/BMP7/ESRRA/UFL1/NR3C1/DDX17/UBA5/ESRRG 11 GO:0002026 regulation of the force of heart contraction 4/725 26/18722 0.0169180859106688 0.0953924109913016 CAV1/ADRB1/GAA/SLC9A1 4 GO:0033598 mammary gland epithelial cell proliferation 4/725 26/18722 0.0169180859106688 0.0953924109913016 CEBPB/KDM5B/RTN4/ZNF703 4 GO:0046639 negative regulation of alpha-beta T cell differentiation 4/725 26/18722 0.0169180859106688 0.0953924109913016 ANXA1/GLI3/SOCS1/HMGB1 4 GO:0060669 embryonic placenta morphogenesis 4/725 26/18722 0.0169180859106688 0.0953924109913016 SPINT1/IGF2/BMP7/SETD2 4 GO:0045069 regulation of viral genome replication 8/725 85/18722 0.0170683023993411 0.0960257767616647 HACD3/DDB1/DDX5/MPHOSPH8/BCL2/LARP1/PKN2/PPIA 8 GO:0071277 cellular response to calcium ion 8/725 85/18722 0.0170683023993411 0.0960257767616647 FOS/FUS/JUND/FOSB/HSPA5/LGMN/IQGAP1/SYT7 8 GO:0051099 positive regulation of binding 13/725 173/18722 0.0172786442603242 0.0970450927116822 CAV1/LRP1/APP/MET/CALM1/ISL1/PARP1/EDF1/RALB/HES1/RIPK2/HMGB1/B2M 13 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 17/725 249/18722 0.0172877724834581 0.0970450927116822 GAPDH/WLS/BRD4/TFRC/GJA1/RHOA/HSPB1/ASH1L/DHX36/USP10/TLE1/UFL1/SLC20A1/NEK6/TMED4/CFLAR/RIPK2 17 GO:0030595 leukocyte chemotaxis 16/725 230/18722 0.0175094875114982 0.0981809648183458 CSF3R/MIF/S100A9/DUSP1/ANXA1/PGF/RPS19/JAM3/PDE4B/LGMN/PLEC/HMGB1/SERPINE1/RAC1/FLT1/PPIA 16 GO:0055123 digestive system development 11/725 137/18722 0.017559355734928 0.0981866458551994 WLS/IGF2/LGR4/EGFR/GLI3/IL6ST/COBL/BCL2/NIPBL/CDKN1A/HES1 11 GO:0001706 endoderm formation 6/725 54/18722 0.017606112099296 0.0981866458551994 ITGAV/LAMB1/DUSP1/COL4A2/RTF1/SETD2 6 GO:0030520 intracellular estrogen receptor signaling pathway 6/725 54/18722 0.017606112099296 0.0981866458551994 DDX5/ISL1/PARP1/UFL1/DDX17/UBA5 6 GO:0086002 cardiac muscle cell action potential involved in contraction 6/725 54/18722 0.017606112099296 0.0981866458551994 CAV1/GJA1/DSG2/GJA5/DLG1/DSC2 6 GO:0043491 protein kinase B signaling 15/725 211/18722 0.0176073507757696 0.0981866458551994 ITGB1/IGF2/LRP2/DAG1/EGFR/MET/PDCD6/PHLPP1/DLG1/C1QTNF1/RTN4/GDF15/DDIT3/ENG/PIK3CB 15 GO:0006304 DNA modification 10/725 120/18722 0.0181690195362381 0.100493317824668 FOS/PARP1/TET2/MPHOSPH8/DNMT3A/ATRX/TDG/DNMT1/USP9X/MBD3 10 GO:0032411 positive regulation of transporter activity 10/725 120/18722 0.0181690195362381 0.100493317824668 TCAF1/AKAP9/KIF5B/CALM1/TMSB4X/ABCB1/SLC9A1/GLRX/SGK1/GSTO1 10 GO:0051897 positive regulation of protein kinase B signaling 10/725 120/18722 0.0181690195362381 0.100493317824668 ITGB1/IGF2/LRP2/EGFR/MET/C1QTNF1/RTN4/GDF15/ENG/PIK3CB 10 GO:0035051 cardiocyte differentiation 12/725 156/18722 0.0183608650032245 0.100493317824668 ITGB1/TGFBR3/EGFR/TBX3/ISL1/PDCD4/RBPJ/BMP7/DHX36/PLEC/SLC9A1/HES1 12 GO:0002548 monocyte chemotaxis 7/725 70/18722 0.0184224724837764 0.100493317824668 DUSP1/ANXA1/RPS19/LGMN/HMGB1/SERPINE1/FLT1 7 GO:0014037 Schwann cell differentiation 5/725 40/18722 0.0184280162784579 0.100493317824668 ITGB4/DAG1/NF1/DICER1/PLEC 5 GO:0030866 cortical actin cytoskeleton organization 5/725 40/18722 0.0184280162784579 0.100493317824668 EZR/ROCK1/PLEC/DLG1/EPB41L3 5 GO:0043001 Golgi to plasma membrane protein transport 5/725 40/18722 0.0184280162784579 0.100493317824668 KRT18/MACF1/GOLGA4/GOPC/VAMP2 5 GO:0045777 positive regulation of blood pressure 5/725 40/18722 0.0184280162784579 0.100493317824668 ADRB1/NR2F2/RHOA/ADH5/CYBA 5 GO:0060412 ventricular septum morphogenesis 5/725 40/18722 0.0184280162784579 0.100493317824668 TGFBR3/TBX3/RBPJ/SOX4/HES1 5 GO:2000142 regulation of DNA-templated transcription, initiation 5/725 40/18722 0.0184280162784579 0.100493317824668 JUN/ZNF451/DHX36/HMGB1/SUB1 5 GO:0001654 eye development 23/725 371/18722 0.0184287557823778 0.100493317824668 ATP2B1/FBN1/FBN2/TENM3/RPL24/SMOC1/EFEMP1/GLI3/PBX1/LRP5/NF1/BMP7/RDH10/BCL2/DLG1/NIPBL/SERPINF1/C12orf57/TFAP2A/KDM5B/HMGB1/RDH13/FLT1 23 GO:0002027 regulation of heart rate 9/725 103/18722 0.0184493347317557 0.100493317824668 AKAP9/CAV1/ADRB1/CALM1/ISL1/DSG2/MDM2/DSC2/SRI 9 GO:0009135 purine nucleoside diphosphate metabolic process 9/725 103/18722 0.0184493347317557 0.100493317824668 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/DLG1/AK3 9 GO:0009179 purine ribonucleoside diphosphate metabolic process 9/725 103/18722 0.0184493347317557 0.100493317824668 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/DLG1/AK3 9 GO:0014013 regulation of gliogenesis 9/725 103/18722 0.0184493347317557 0.100493317824668 SPINT1/LRP2/DAG1/EGFR/IL6ST/NF1/DICER1/UFL1/HES1 9 GO:0002070 epithelial cell maturation 3/725 15/18722 0.0185760976132795 0.100493317824668 AKR1B1/TFCP2L1/CDKN1A 3 GO:0010452 histone H3-K36 methylation 3/725 15/18722 0.0185760976132795 0.100493317824668 BRD4/ASH1L/SETD2 3 GO:0033599 regulation of mammary gland epithelial cell proliferation 3/725 15/18722 0.0185760976132795 0.100493317824668 KDM5B/RTN4/ZNF703 3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 3/725 15/18722 0.0185760976132795 0.100493317824668 MIF/PTTG1IP/MDM2 3 GO:0048569 post-embryonic animal organ development 3/725 15/18722 0.0185760976132795 0.100493317824668 LDHA/FBN1/EFEMP1 3 GO:0051284 positive regulation of sequestering of calcium ion 3/725 15/18722 0.0185760976132795 0.100493317824668 CALM1/SRI/GSTO1 3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/725 15/18722 0.0185760976132795 0.100493317824668 BTG2/TNRC6B/AGO2 3 GO:0070831 basement membrane assembly 3/725 15/18722 0.0185760976132795 0.100493317824668 DAG1/LAMB1/PHLDB2 3 GO:0086069 bundle of His cell to Purkinje myocyte communication 3/725 15/18722 0.0185760976132795 0.100493317824668 DSG2/GJA5/DSC2 3 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 3/725 15/18722 0.0185760976132795 0.100493317824668 HSPA5/UFL1/PPP1R15A 3 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/725 15/18722 0.0185760976132795 0.100493317824668 DHX36/TNRC6B/AGO2 3 GO:1901841 regulation of high voltage-gated calcium channel activity 3/725 15/18722 0.0185760976132795 0.100493317824668 CALM1/PDE4B/SRI 3 GO:0016236 macroautophagy 19/725 291/18722 0.0188826451180254 0.102042780493892 GAPDH/CALM1/ATP6V0E1/BNIP3L/LARP1/HSPB8/UFL1/UBA5/EXOC1/RALB/HUWE1/TMEM41B/UVRAG/PIP4K2A/RIPK2/RAB1A/MAP1LC3B/ARL8B/ATP6V1G1 19 GO:0045862 positive regulation of proteolysis 23/725 372/18722 0.0189542534556022 0.102320671742756 CAV1/FBLN1/APP/PMAIP1/S100A9/HSPD1/CTSC/NFE2L2/PDCD6/GRN/RHOA/ENO1/LGMN/CLDN4/HERPUD1/ARL6IP5/HSPA1A/MDM2/ASPH/DDA1/CFLAR/RIPK2/HMGB1 23 GO:0031113 regulation of microtubule polymerization 6/725 55/18722 0.0191356529443604 0.103021161648591 AKAP9/CLIP1/MET/HSPA1A/NUMA1/RAC1 6 GO:0051898 negative regulation of protein kinase B signaling 6/725 55/18722 0.0191356529443604 0.103021161648591 DAG1/PDCD6/PHLPP1/DLG1/DDIT3/PIK3CB 6 GO:0038127 ERBB signaling pathway 10/725 121/18722 0.019144986047144 0.103021161648591 EGFR/EFEMP1/NEURL1/RBPJ/LGMN/IQGAP1/PTPN12/RTN4/ARF4/CBLB 10 GO:0007034 vacuolar transport 12/725 157/18722 0.0192077473716596 0.103021214828741 LRP1/HSPA8/GRN/LEPROTL1/PSAP/HOOK3/HSPA1A/RHOB/HGSNAT/SNX27/ARF1/ARL8B 12 GO:1902107 positive regulation of leukocyte differentiation 12/725 157/18722 0.0192077473716596 0.103021214828741 FOS/CD46/JUN/PRKDC/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/RIPK2/HMGB1 12 GO:1903708 positive regulation of hemopoiesis 12/725 157/18722 0.0192077473716596 0.103021214828741 FOS/CD46/JUN/PRKDC/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/RIPK2/HMGB1 12 GO:0003272 endocardial cushion formation 4/725 27/18722 0.0192669385791372 0.103021214828741 TBX3/RBPJ/BMP7/ENG 4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 4/725 27/18722 0.0192669385791372 0.103021214828741 BRD4/APP/PBX1/RAB11A 4 GO:0033688 regulation of osteoblast proliferation 4/725 27/18722 0.0192669385791372 0.103021214828741 ITGAV/RHOA/LRP5/BCL2 4 GO:0001776 leukocyte homeostasis 8/725 87/18722 0.0193907931629229 0.103454347932719 PMAIP1/RPS6/ANXA1/JAM3/PDE4B/BCL2/HMGB1/PIK3CB 8 GO:2000177 regulation of neural precursor cell proliferation 8/725 87/18722 0.0193907931629229 0.103454347932719 SPINT1/ADGRG1/LRP2/BTG2/GLI3/RHOA/NF1/SLC6A4 8 GO:0051962 positive regulation of nervous system development 18/725 272/18722 0.0194091704249389 0.103454347932719 SPINT1/LRP1/DLG5/CUX1/LRP2/DAG1/EGFR/NEURL1/MACF1/GOLGA4/GLI3/IL6ST/DHX36/DICER1/UFL1/SERPINF1/HES1/RAB11A 18 GO:0045621 positive regulation of lymphocyte differentiation 9/725 104/18722 0.0195293985471178 0.103985841633761 CD46/PRKDC/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/RIPK2 9 GO:0000281 mitotic cytokinesis 7/725 71/18722 0.0197783279131773 0.105090507538675 SON/MYH10/RHOA/ROCK1/RHOB/RASA1/ARF1 7 GO:0003208 cardiac ventricle morphogenesis 7/725 71/18722 0.0197783279131773 0.105090507538675 LRP2/TGFBR3/ISL1/RBPJ/SOX4/LY6E/ENG 7 GO:0007389 pattern specification process 26/725 436/18722 0.019944636146587 0.105863204845078 NRP2/WLS/GALNT11/BASP1/ADGRG1/LRP2/PRKDC/TBX3/NR2F2/BTG2/ISL1/RBPJ/GLI3/PBX1/LRP5/BMP7/GPC3/COBL/BPTF/MIB1/TRA2B/IRX2/ATP6AP2/HES1/DDIT3/ENG 26 GO:0031333 negative regulation of protein-containing complex assembly 11/725 140/18722 0.0202943800140834 0.107606916622792 KANK1/ISL1/TRIOBP/TMSB4X/JAM3/RPL13A/HSPA5/PFN1/CDC42/HMGB1/CAPZB 11 GO:0150063 visual system development 23/725 375/18722 0.0206013920888296 0.109120644198827 ATP2B1/FBN1/FBN2/TENM3/RPL24/SMOC1/EFEMP1/GLI3/PBX1/LRP5/NF1/BMP7/RDH10/BCL2/DLG1/NIPBL/SERPINF1/C12orf57/TFAP2A/KDM5B/HMGB1/RDH13/FLT1 23 GO:0010232 vascular transport 8/725 88/18722 0.0206327783502194 0.109172811542027 LRP1/LRP2/TFRC/GJA1/SLC16A12/SLC38A1/ABCB1/SLC7A5 8 GO:0040029 regulation of gene expression, epigenetic 9/725 105/18722 0.0206544698557706 0.109173626380502 IGF2/MPHOSPH8/DNMT3A/SERTAD1/SERTAD2/TDG/CDYL/DNMT1/MBD3 9 GO:0043388 positive regulation of DNA binding 6/725 56/18722 0.0207533429318216 0.109526940644876 CALM1/ISL1/PARP1/EDF1/HES1/HMGB1 6 GO:0051604 protein maturation 19/725 294/18722 0.0207645275122757 0.109526940644876 PISD/GLG1/DHCR24/HSPD1/PARP1/ENPEP/SOX4/GLI3/CTSL/ENO1/AFG3L2/LGMN/MDM2/ATP6AP2/ASPH/ERO1A/SERPINH1/RIPK2/SERPINE1 19 GO:0043410 positive regulation of MAPK cascade 28/725 480/18722 0.0209441613844725 0.110359619602798 IGF2/LRP1/MAP3K4/MIF/APP/MAGED1/EGFR/GADD45B/SPAG9/ROCK1/APELA/ARL6IP5/GHR/IQGAP1/C1QTNF1/CDC42/SASH1/HRAS/ERP29/SEMA4C/GDF15/CFLAR/RIPK2/HMGB1/FLT1/PPIA/TIMP2/SDCBP 28 GO:0018205 peptidyl-lysine modification 23/725 376/18722 0.0211745376932418 0.111304870899089 BRD4/KMT2C/ISL1/CBX4/TET2/SOX4/HMG20B/ATRX/ZNF451/ASH1L/BRD7/NCOA3/PHF20/USP22/MDM2/HINT1/RTF1/RANBP2/EID1/DNMT1/SETD2/MBD3/MORF4L2 23 GO:0001707 mesoderm formation 7/725 72/18722 0.0212023253350492 0.111304870899089 WLS/ITGB1/ITGB4/GJA1/BMP7/APELA/TXNRD1 7 GO:0033627 cell adhesion mediated by integrin 7/725 72/18722 0.0212023253350492 0.111304870899089 FBN1/ITGB1/ITGB4/ITGAV/PLPP3/JAM3/SERPINE1 7 GO:0010811 positive regulation of cell-substrate adhesion 10/725 123/18722 0.0212113839590689 0.111304870899089 UTRN/DAG1/CCDC80/ITGA6/TRIOBP/P4HB/ROCK1/IQGAP1/CDC42/RAC1 10 GO:0016241 regulation of macroautophagy 11/725 141/18722 0.0212723243613614 0.111509216326516 GAPDH/ATP6V0E1/BNIP3L/LARP1/HSPB8/EXOC1/RALB/UVRAG/PIP4K2A/RIPK2/ATP6V1G1 11 GO:0035265 organ growth 13/725 178/18722 0.0213304561782975 0.11169843219813 IGF2/BASP1/TGFBR3/GJA1/DUSP6/RBPJ/PSAP/SLC6A4/DUSP9/LATS2/BCL2/LY6E/SERP1 13 GO:0016072 rRNA metabolic process 16/725 236/18722 0.0217222298848018 0.113301405679506 RPS21/RPL14/PRKDC/RPS6/RPS16/RPS8/RPS25/RPL26/RPS19/RPL10A/DDX17/RPL7A/RPL7/RPL27/SNU13/NOP10 16 GO:0048738 cardiac muscle tissue development 16/725 236/18722 0.0217222298848018 0.113301405679506 ITGB1/LRP2/TGFBR3/GJA1/TBX3/ISL1/RBPJ/BMP7/DSG2/GJA5/PLEC/SLC9A1/CDC42/HOPX/LY6E/ENG 16 GO:0000470 maturation of LSU-rRNA 4/725 28/18722 0.0218074875278365 0.113301405679506 RPL10A/RPL7A/RPL7/SNU13 4 GO:0034123 positive regulation of toll-like receptor signaling pathway 4/725 28/18722 0.0218074875278365 0.113301405679506 CAV1/RTN4/HMGB1/CYBA 4 GO:0009185 ribonucleoside diphosphate metabolic process 9/725 106/18722 0.0218254922707679 0.113301405679506 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/DLG1/AK3 9 GO:1900407 regulation of cellular response to oxidative stress 8/725 89/18722 0.021930176493312 0.113301405679506 MET/PARP1/NFE2L2/HSPB1/BMP7/P4HB/FUT8/PPIA 8 GO:0001732 formation of cytoplasmic translation initiation complex 3/725 16/18722 0.0222175241171897 0.113301405679506 EIF2S2/EIF3H/EIF3I 3 GO:0001977 renal system process involved in regulation of blood volume 3/725 16/18722 0.0222175241171897 0.113301405679506 GJA1/GJA5/CYBA 3 GO:0003084 positive regulation of systemic arterial blood pressure 3/725 16/18722 0.0222175241171897 0.113301405679506 NR2F2/RHOA/CYBA 3 GO:0005980 glycogen catabolic process 3/725 16/18722 0.0222175241171897 0.113301405679506 AGL/GAA/HMGB1 3 GO:0009415 response to water 3/725 16/18722 0.0222175241171897 0.113301405679506 KRT8/AKR1B1/PLEC 3 GO:0017014 protein nitrosylation 3/725 16/18722 0.0222175241171897 0.113301405679506 GAPDH/S100A9/ADH5 3 GO:0018119 peptidyl-cysteine S-nitrosylation 3/725 16/18722 0.0222175241171897 0.113301405679506 GAPDH/S100A9/ADH5 3 GO:0021535 cell migration in hindbrain 3/725 16/18722 0.0222175241171897 0.113301405679506 ITGB1/RERE/SEMA4C 3 GO:0021783 preganglionic parasympathetic fiber development 3/725 16/18722 0.0222175241171897 0.113301405679506 NRP2/TFAP2A/HES1 3 GO:0032274 gonadotropin secretion 3/725 16/18722 0.0222175241171897 0.113301405679506 GJA1/TBX3/INHA 3 GO:0051238 sequestering of metal ion 3/725 16/18722 0.0222175241171897 0.113301405679506 S100A9/FTH1/SRI 3 GO:0090520 sphingolipid mediated signaling pathway 3/725 16/18722 0.0222175241171897 0.113301405679506 EZR/RAC1/PIK3CB 3 GO:0097202 activation of cysteine-type endopeptidase activity 3/725 16/18722 0.0222175241171897 0.113301405679506 LGMN/ASPH/RIPK2 3 GO:0099633 protein localization to postsynaptic specialization membrane 3/725 16/18722 0.0222175241171897 0.113301405679506 DAG1/DLG1/HRAS 3 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 3/725 16/18722 0.0222175241171897 0.113301405679506 DAG1/DLG1/HRAS 3 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/725 16/18722 0.0222175241171897 0.113301405679506 MIF/RPL26/BCL2 3 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 3/725 16/18722 0.0222175241171897 0.113301405679506 KIF5B/SLC9A1/GLRX 3 GO:2000765 regulation of cytoplasmic translation 3/725 16/18722 0.0222175241171897 0.113301405679506 PKM/DHX36/CPEB4 3 GO:2001224 positive regulation of neuron migration 3/725 16/18722 0.0222175241171897 0.113301405679506 SEMA6A/NIPBL/ZNF609 3 GO:0021795 cerebral cortex cell migration 5/725 42/18722 0.0223741777638954 0.113301405679506 ADGRG1/LAMB1/GLI3/RHOA/RTN4 5 GO:0030890 positive regulation of B cell proliferation 5/725 42/18722 0.0223741777638954 0.113301405679506 MIF/TFRC/SLC39A10/BCL2/CDKN1A 5 GO:0035019 somatic stem cell population maintenance 5/725 42/18722 0.0223741777638954 0.113301405679506 RBPJ/SOX4/LRP5/BMP7/HES1 5 GO:0045047 protein targeting to ER 5/725 42/18722 0.0223741777638954 0.113301405679506 HSPA5/SEC62/HERPUD1/SEC61B/SEC61G 5 GO:0045214 sarcomere organization 5/725 42/18722 0.0223741777638954 0.113301405679506 KRT19/KRT8/ITGB1/ACTG1/PLEC 5 GO:0045687 positive regulation of glial cell differentiation 5/725 42/18722 0.0223741777638954 0.113301405679506 SPINT1/DAG1/IL6ST/DICER1/HES1 5 GO:0060999 positive regulation of dendritic spine development 5/725 42/18722 0.0223741777638954 0.113301405679506 DLG5/NEURL1/PPP1R9A/DHX36/ARF1 5 GO:0072595 maintenance of protein localization in organelle 5/725 42/18722 0.0223741777638954 0.113301405679506 GJA1/SKP1/HSPA5/KDELR2/CHCHD10 5 GO:0061005 cell differentiation involved in kidney development 6/725 57/18722 0.0224612087626161 0.113515321253939 BASP1/LGR4/GLI3/IQGAP1/MTSS1/HES1 6 GO:0097120 receptor localization to synapse 6/725 57/18722 0.0224612087626161 0.113515321253939 DAG1/KIF5B/DLG1/HRAS/VAMP2/RAB11A 6 GO:0072089 stem cell proliferation 7/725 73/18722 0.0226959712586568 0.114587528197342 FBLN1/GJA1/TBX3/RNF43/ZNRF3/ABCB1/N4BP2L2 7 GO:0036503 ERAD pathway 9/725 107/18722 0.0230433923491598 0.116225826684469 CAV1/NFE2L2/HSP90B1/HSPA5/UBXN4/HERPUD1/CCDC47/DNAJB14/SEC61B 9 GO:0007033 vacuole organization 13/725 180/18722 0.0231356948879985 0.116575385076803 GAA/GRN/HOOK3/TFEB/ATP6AP2/SYT7/RALB/TMEM41B/PIP4K2A/RAB1A/ARF1/MAP1LC3B/ARL8B 13 GO:0002028 regulation of sodium ion transport 8/725 90/18722 0.0232841422979601 0.116858730008277 FXYD3/UTRN/KIF5B/STOM/SLC9A1/DLG1/ARF1/GLRX 8 GO:0032392 DNA geometric change 8/725 90/18722 0.0232841422979601 0.116858730008277 HMGB3/ANXA1/ATRX/DHX36/RAD50/PURA/CHD4/HMGB1 8 GO:0034644 cellular response to UV 8/725 90/18722 0.0232841422979601 0.116858730008277 DDB1/PARP1/RPL26/OPN3/NPM1/DHX36/MDM2/CDKN1A 8 GO:0046031 ADP metabolic process 8/725 90/18722 0.0232841422979601 0.116858730008277 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/AK3 8 GO:0038061 NIK/NF-kappaB signaling 11/725 143/18722 0.0233314587102264 0.116980380021897 APP/EGFR/PDCD4/TMSB4X/RHOA/BMP7/TRIM44/NFAT5/DICER1/SASH1/HMGB1 11 GO:2000027 regulation of animal organ morphogenesis 10/725 125/18722 0.0234355224154882 0.117386030755049 LGR4/MAGED1/ZNRF3/RHOA/BMP7/GPC3/SP6/CDC42/TACSTD2/RAC1 10 GO:0051100 negative regulation of binding 12/725 162/18722 0.0238855091416514 0.11952186163774 C4orf3/CAV1/JUN/TMSB4X/LRPAP1/ROCK1/PTPRF/RALB/CDKN1A/DDIT3/SRI/B2M 12 GO:0051881 regulation of mitochondrial membrane potential 7/725 74/18722 0.0242607202381172 0.120450448668647 PMAIP1/PARP1/BNIP3L/SLC25A36/BCL2/ARL6IP5/CLIC1 7 GO:0002931 response to ischemia 6/725 58/18722 0.0242611773704258 0.120450448668647 CAV1/HSPD1/GJA1/BCL2/CPEB4/PIK3CB 6 GO:0018208 peptidyl-proline modification 6/725 58/18722 0.0242611773704258 0.120450448668647 P4HB/NKTR/PPIG/RANBP2/ERO1A/PPIA 6 GO:0032481 positive regulation of type I interferon production 6/725 58/18722 0.0242611773704258 0.120450448668647 GAPDH/HSPD1/DHX36/SETD2/RIPK2/HMGB1 6 GO:0042743 hydrogen peroxide metabolic process 6/725 58/18722 0.0242611773704258 0.120450448668647 GPX3/PRDX6/EGFR/CAT/RAC1/CYBA 6 GO:2000649 regulation of sodium ion transmembrane transporter activity 6/725 58/18722 0.0242611773704258 0.120450448668647 FXYD3/UTRN/KIF5B/STOM/SLC9A1/GLRX 6 GO:2000736 regulation of stem cell differentiation 6/725 58/18722 0.0242611773704258 0.120450448668647 PRKDC/NFE2L2/N4BP2L2/DHX36/HES1/TACSTD2 6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/725 58/18722 0.0242611773704258 0.120450448668647 CAV1/PMAIP1/S100A9/RPL26/DDIT3/EIF5A 6 GO:0106106 cold-induced thermogenesis 11/725 144/18722 0.0244139031832879 0.120668547485105 CAV1/LGR4/ADRB1/GJA1/RBPJ/ARRDC3/SCD/DYNC1H1/CEBPB/DDIT3/ESRRG 11 GO:0120161 regulation of cold-induced thermogenesis 11/725 144/18722 0.0244139031832879 0.120668547485105 CAV1/LGR4/ADRB1/GJA1/RBPJ/ARRDC3/SCD/DYNC1H1/CEBPB/DDIT3/ESRRG 11 GO:0031952 regulation of protein autophosphorylation 5/725 43/18722 0.0245372869741578 0.120668547485105 CAV1/CALM1/RAD50/IQGAP1/ENG 5 GO:0035794 positive regulation of mitochondrial membrane permeability 5/725 43/18722 0.0245372869741578 0.120668547485105 BNIP3L/NMT1/HSPA1A/SLC9A1/CHCHD10 5 GO:0060443 mammary gland morphogenesis 5/725 43/18722 0.0245372869741578 0.120668547485105 CAV1/TBX3/GLI3/LRP5/KDM5B 5 GO:0120178 steroid hormone biosynthetic process 5/725 43/18722 0.0245372869741578 0.120668547485105 CYP11A1/AKR1B1/HSD3B1/HSD17B1/CYP19A1 5 GO:0002360 T cell lineage commitment 4/725 29/18722 0.0245431588986275 0.120668547485105 PRKDC/CTSL/RHOA/BCL2 4 GO:0033028 myeloid cell apoptotic process 4/725 29/18722 0.0245431588986275 0.120668547485105 ANXA1/CTSL/BCL2/PIK3CB 4 GO:0071549 cellular response to dexamethasone stimulus 4/725 29/18722 0.0245431588986275 0.120668547485105 EGFR/NR3C1/SERPINF1/CFLAR 4 GO:0090025 regulation of monocyte chemotaxis 4/725 29/18722 0.0245431588986275 0.120668547485105 DUSP1/LGMN/HMGB1/SERPINE1 4 GO:0048705 skeletal system morphogenesis 15/725 220/18722 0.024583208328655 0.120748336257706 FBN2/GLG1/ANKRD11/GLI3/LRP5/BMP7/RDH10/ARID5B/GHR/DLG1/TRIP11/NIPBL/TFAP2A/SETD2/SERPINH1 15 GO:2001235 positive regulation of apoptotic signaling pathway 10/725 126/18722 0.0246086226254371 0.120756154974192 CAV1/PMAIP1/S100A9/CTSC/MAGED1/RPL26/DDIT3/EIF5A/ATF3/TIMP3 10 GO:0045582 positive regulation of T cell differentiation 8/725 91/18722 0.0246958001563953 0.120949769075138 CD46/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/RIPK2 8 GO:0060191 regulation of lipase activity 8/725 91/18722 0.0246958001563953 0.120949769075138 LRP1/EGFR/ANXA1/RHOA/GNAQ/HRAS/ARF4/FLT1 8 GO:0050657 nucleic acid transport 12/725 163/18722 0.0249134993489855 0.121572983404433 NCBP3/NPM1/IGF2BP3/SRSF7/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A/YBX1 12 GO:0050658 RNA transport 12/725 163/18722 0.0249134993489855 0.121572983404433 NCBP3/NPM1/IGF2BP3/SRSF7/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A/YBX1 12 GO:0006403 RNA localization 14/725 201/18722 0.024918983972619 0.121572983404433 NCBP3/NPM1/DHX36/IGF2BP3/SRSF7/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A/NOP10/YBX1 14 GO:0051054 positive regulation of DNA metabolic process 14/725 201/18722 0.024918983972619 0.121572983404433 MAP3K4/TFRC/FUS/PRKDC/EGFR/PARP1/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/USP9X/HMGB1 14 GO:0051251 positive regulation of lymphocyte activation 22/725 362/18722 0.0253727309275349 0.123667666415072 CAV1/IGF2/CD46/MIF/TFRC/SLC39A10/HSPD1/PRKDC/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1/B2M 22 GO:0001819 positive regulation of cytokine production 27/725 467/18722 0.0254582094540869 0.12396509483455 GAPDH/LRP1/CD46/MIF/APP/HSPD1/ANXA1/ISL1/PNP/IL6ST/PDE4B/HSPB1/DHX36/CEBPB/HSPA1A/ATP6AP2/CD55/HRAS/SETD2/DDIT3/RIPK2/HMGB1/RAB1A/SERPINE1/SLC7A5/B2M/CYBA 27 GO:0032414 positive regulation of ion transmembrane transporter activity 9/725 109/18722 0.0256234388875508 0.124649915279266 TCAF1/AKAP9/KIF5B/CALM1/TMSB4X/ABCB1/SLC9A1/GLRX/GSTO1 9 GO:0043627 response to estrogen 7/725 75/18722 0.0258979721756595 0.125864641379116 KRT19/LDHA/SERPINB9/CAV1/HSPD1/GLI3/MDM2 7 GO:0006767 water-soluble vitamin metabolic process 6/725 59/18722 0.0261550719092963 0.126212453133603 SLC19A3/SLC52A3/MTR/SLC52A1/RFK/GSTO1 6 GO:0043407 negative regulation of MAP kinase activity 6/725 59/18722 0.0261550719092963 0.126212453133603 CAV1/DUSP1/PDCD4/NF1/BMP7/PIK3CB 6 GO:0032465 regulation of cytokinesis 8/725 92/18722 0.0261662423646689 0.126212453133603 CALM1/RHOA/PKN2/BIRC6/CDC42/UVRAG/SETD2/RAB11A 8 GO:1903312 negative regulation of mRNA metabolic process 8/725 92/18722 0.0261662423646689 0.126212453133603 FUS/SAP18/NPM1/SRSF9/SRSF7/LARP1/SRSF6/YBX1 8 GO:0009251 glucan catabolic process 3/725 17/18722 0.0262185269579175 0.126212453133603 AGL/GAA/HMGB1 3 GO:0016264 gap junction assembly 3/725 17/18722 0.0262185269579175 0.126212453133603 CAV1/GJA1/GJA5 3 GO:0048532 anatomical structure arrangement 3/725 17/18722 0.0262185269579175 0.126212453133603 NRP2/HSPA5/TFAP2A 3 GO:0060263 regulation of respiratory burst 3/725 17/18722 0.0262185269579175 0.126212453133603 GRN/RPS19/RAC1 3 GO:0060977 coronary vasculature morphogenesis 3/725 17/18722 0.0262185269579175 0.126212453133603 LRP2/TGFBR3/SETD2 3 GO:0070293 renal absorption 3/725 17/18722 0.0262185269579175 0.126212453133603 CLDN4/MAGED2/SGK1 3 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 5/725 44/18722 0.0268303227118166 0.12866878507682 DLG5/RHOA/DLG1/CDC42/ARF4 5 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 5/725 44/18722 0.0268303227118166 0.12866878507682 AKR1B1/CSH1/SOCS1/GHR/HES1 5 GO:0048806 genitalia development 5/725 44/18722 0.0268303227118166 0.12866878507682 LGR4/LRP2/DHCR24/TBX3/NIPBL 5 GO:0060711 labyrinthine layer development 5/725 44/18722 0.0268303227118166 0.12866878507682 SPINT1/RBPJ/BMP7/BIRC6/HES1 5 GO:0032103 positive regulation of response to external stimulus 25/725 427/18722 0.0269259445906913 0.129005305416081 NEAT1/LRP1/APP/S100A9/HSPD1/CTSC/PRKDC/EGFR/MET/PDCD4/PGF/TMSB4X/GRN/IL6ST/RPS19/HSPB1/PUM1/LGMN/CEBPB/SASH1/RIPK2/HMGB1/SERPINE1/RAC1/CYBA 25 GO:0055001 muscle cell development 13/725 184/18722 0.0270827828800058 0.129511911715801 KRT19/KRT8/ITGB1/TBX3/ISL1/HOMER1/ACTG1/BCL2/AFG3L2/PLEC/HES1/CFLAR/ENG 13 GO:2001257 regulation of cation channel activity 13/725 184/18722 0.0270827828800058 0.129511911715801 CAV1/ITGB1/APP/KIF5B/STOM/CALM1/TMSB4X/PDE4B/HOMER1/DLG1/VAMP2/SRI/GSTO1 13 GO:0050920 regulation of chemotaxis 15/725 223/18722 0.0273151265708692 0.130499883683069 MIF/SEMA6D/SEMA6A/DUSP1/MET/PGF/TMSB4X/JAM3/MYCBP2/HSPB1/LGMN/SEMA4C/HMGB1/SERPINE1/RAC1 15 GO:0000132 establishment of mitotic spindle orientation 4/725 30/18722 0.027476793229866 0.130656533660592 ITGB1/GJA1/GPSM2/NUMA1 4 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 4/725 30/18722 0.027476793229866 0.130656533660592 APP/CALM1/BMP7/RIPK2 4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 4/725 30/18722 0.027476793229866 0.130656533660592 CTSL/CTSV/LGMN/B2M 4 GO:0036296 response to increased oxygen levels 4/725 30/18722 0.027476793229866 0.130656533660592 CAV1/CAT/CDKN1A/ATP6V1G1 4 GO:0060218 hematopoietic stem cell differentiation 4/725 30/18722 0.027476793229866 0.130656533660592 PRKDC/NFE2L2/N4BP2L2/UFL1 4 GO:0006305 DNA alkylation 7/725 76/18722 0.0276090697754713 0.13092652178883 FOS/PARP1/MPHOSPH8/DNMT3A/ATRX/DNMT1/MBD3 7 GO:0006306 DNA methylation 7/725 76/18722 0.0276090697754713 0.13092652178883 FOS/PARP1/MPHOSPH8/DNMT3A/ATRX/DNMT1/MBD3 7 GO:0045860 positive regulation of protein kinase activity 23/725 386/18722 0.0276110577613454 0.13092652178883 IGF2/MAP3K4/DAG1/MAGED1/EGFR/RPLP1/NEURL1/CALM1/RHOA/PPP1R9A/NPM1/SOCS1/GHR/DLG1/IQGAP1/RALB/SASH1/HRAS/CDKN1A/ERP29/HMGB1/FLT1/PPIA 23 GO:0106027 neuron projection organization 8/725 93/18722 0.027696527406168 0.131086552214627 APP/PPP1R9A/HOMER1/DHX36/LGMN/CFL1/CDC42/ARF1 8 GO:1901992 positive regulation of mitotic cell cycle phase transition 8/725 93/18722 0.027696527406168 0.131086552214627 BRD4/APP/EGFR/ANXA1/PBX1/ADAMTS1/MDM2/RAB11A 8 GO:0006893 Golgi to plasma membrane transport 6/725 60/18722 0.0281446081205006 0.132810511290899 KRT18/MACF1/GOLGA4/GOPC/EXOC1/VAMP2 6 GO:0055008 cardiac muscle tissue morphogenesis 6/725 60/18722 0.0281446081205006 0.132810511290899 LRP2/TGFBR3/ISL1/RBPJ/LY6E/ENG 6 GO:0061951 establishment of protein localization to plasma membrane 6/725 60/18722 0.0281446081205006 0.132810511290899 KRT18/MACF1/GOLGA4/GOPC/VAMP2/RAB11A 6 GO:0030307 positive regulation of cell growth 12/725 166/18722 0.0281917755275216 0.132810511290899 LRP1/S100A9/EGFR/MACF1/GOLGA4/RHOA/BCL2/SLC9A1/CDC42/RAB11A/SDCBP/CYBA 12 GO:0051236 establishment of RNA localization 12/725 166/18722 0.0281917755275216 0.132810511290899 NCBP3/NPM1/IGF2BP3/SRSF7/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A/YBX1 12 GO:0090288 negative regulation of cellular response to growth factor stimulus 9/725 111/18722 0.0284016334891278 0.133674911937223 FBN1/LRP2/SEMA6A/FSTL3/PDCD6/CRIM1/UBE2D3/CFLAR/PIK3CB 9 GO:1903706 regulation of hemopoiesis 22/725 367/18722 0.0289854692702101 0.136076298188397 FBN1/CSF3R/FOS/CD46/JUN/PRKDC/ANXA1/FSTL3/PNP/SOX4/GLI3/RHOA/SOCS1/ESRRA/CEBPB/HSPA1A/RCOR1/FAM210B/INHA/RIPK2/HMGB1/B2M 22 GO:0002696 positive regulation of leukocyte activation 24/725 409/18722 0.0290491840035164 0.136076298188397 CAV1/IGF2/CD46/MIF/TFRC/JUND/SLC39A10/HSPD1/CTSC/PRKDC/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1/B2M 24 GO:0035148 tube formation 11/725 148/18722 0.0291104201230978 0.136076298188397 SPINT1/LRP2/SOX4/BMP7/COBL/MIB1/IRX2/PFN1/BRD2/SETD2/SEMA4C 11 GO:2001056 positive regulation of cysteine-type endopeptidase activity 11/725 148/18722 0.0291104201230978 0.136076298188397 PMAIP1/S100A9/HSPD1/PDCD6/RHOA/LGMN/ARL6IP5/ASPH/CFLAR/RIPK2/HMGB1 11 GO:0120032 regulation of plasma membrane bounded cell projection assembly 13/725 186/18722 0.0292317888982455 0.136076298188397 CAV1/KANK1/NEURL1/EPS8L1/PPP1R9A/COBL/WASF2/PFN1/CDC42/HRAS/TACSTD2/RAC1/CAPZB 13 GO:0030850 prostate gland development 5/725 45/18722 0.0292554308258847 0.136076298188397 ANXA1/GLI3/PSAP/BMP7/SERPINF1 5 GO:0035987 endodermal cell differentiation 5/725 45/18722 0.0292554308258847 0.136076298188397 ITGAV/LAMB1/COL4A2/RTF1/SETD2 5 GO:0051180 vitamin transport 5/725 45/18722 0.0292554308258847 0.136076298188397 LRP2/SLC19A3/SLC52A3/SLC52A1/SLC2A8 5 GO:0071364 cellular response to epidermal growth factor stimulus 5/725 45/18722 0.0292554308258847 0.136076298188397 EEF1A1/EGFR/IQGAP1/PTPN12/CFLAR 5 GO:1904646 cellular response to amyloid-beta 5/725 45/18722 0.0292554308258847 0.136076298188397 LRP1/APP/GJA1/PARP1/LGMN 5 GO:0016485 protein processing 15/725 225/18722 0.0292574791913934 0.136076298188397 PISD/GLG1/DHCR24/PARP1/ENPEP/GLI3/CTSL/ENO1/AFG3L2/LGMN/MDM2/ATP6AP2/ASPH/RIPK2/SERPINE1 15 GO:0001738 morphogenesis of a polarized epithelium 8/725 94/18722 0.0292876783041114 0.136076298188397 DLG5/LAMA5/ZNRF3/RHOA/GPC3/ACTG1/CDC42/RAC1 8 GO:0014020 primary neural tube formation 8/725 94/18722 0.0292876783041114 0.136076298188397 SPINT1/LRP2/BMP7/COBL/PFN1/BRD2/SETD2/SEMA4C 8 GO:1990830 cellular response to leukemia inhibitory factor 8/725 94/18722 0.0292876783041114 0.136076298188397 NRP2/TLE4/TFRC/RPS16/B3GNT2/SRSF7/ARID5B/KDM5B 8 GO:0007254 JNK cascade 12/725 167/18722 0.0293509923681499 0.136245586368271 APP/HACD3/EGFR/GADD45B/PDCD4/PHLPP1/DUSP9/CDC42/HRAS/RIPK2/HMGB1/SDCBP 12 GO:0031016 pancreas development 7/725 77/18722 0.0293952961514666 0.136326400907396 WLS/IGF2/ANXA1/MET/ISL1/SOX4/HES1 7 GO:0010639 negative regulation of organelle organization 21/725 347/18722 0.0295977288924236 0.137139751147802 KANK1/TFRC/DUSP1/MET/PARP1/TRIOBP/TMSB4X/PPP1R9A/NPM1/BMP7/ATRX/RAD50/WASF2/HSPA1A/HNRNPA1/PHLDB2/PFN1/HUWE1/TACSTD2/CENPF/CAPZB 21 GO:0042476 odontogenesis 10/725 130/18722 0.0297247475240205 0.137476957298595 CSF3R/LAMB1/LAMA5/ANKRD11/GLI3/RHOA/BMP7/SP6/TFAP2A/SERPINE1 10 GO:0051028 mRNA transport 10/725 130/18722 0.0297247475240205 0.137476957298595 NCBP3/IGF2BP3/SRSF7/PABPN1/HNRNPA1/RANBP2/QKI/UPF2/SETD2/EIF5A 10 GO:0032609 interferon-gamma production 9/725 112/18722 0.0298671364218429 0.137758429956617 HSPD1/ISL1/PDE4B/HRAS/INHA/DDIT3/RIPK2/HMGB1/SLC7A5 9 GO:0032649 regulation of interferon-gamma production 9/725 112/18722 0.0298671364218429 0.137758429956617 HSPD1/ISL1/PDE4B/HRAS/INHA/DDIT3/RIPK2/HMGB1/SLC7A5 9 GO:0043406 positive regulation of MAP kinase activity 9/725 112/18722 0.0298671364218429 0.137758429956617 MAP3K4/MAGED1/EGFR/GHR/IQGAP1/SASH1/HRAS/ERP29/FLT1 9 GO:0034113 heterotypic cell-cell adhesion 6/725 61/18722 0.0302313910768808 0.13866435571569 ITGB1/ITGAV/JAM3/BMP7/DSG2/DSC2 6 GO:1905039 carboxylic acid transmembrane transport 11/725 149/18722 0.0303791825571167 0.13866435571569 ITGB1/LRP2/SLC38A1/ABCB1/SLC7A6/ARL6IP5/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5 11 GO:0050900 leukocyte migration 22/725 369/18722 0.0305349950859075 0.13866435571569 CSF3R/ITGB1/MIF/APP/S100A9/DUSP1/ANXA1/PGF/RPS19/RHOA/JAM3/PDE4B/ROCK1/LGMN/PLEC/CDC42/HMGB1/CD99/SERPINE1/RAC1/FLT1/PPIA 22 GO:1902806 regulation of cell cycle G1/S phase transition 12/725 168/18722 0.0305442634912047 0.13866435571569 PRKDC/EGFR/CTDSPL/ANXA1/SOX4/RPL26/ADAMTS1/BRD7/BCL2/DLG1/MDM2/CDKN1A 12 GO:0002643 regulation of tolerance induction 3/725 18/18722 0.0305779694579326 0.13866435571569 PHLPP1/HMGB1/CBLB 3 GO:0003128 heart field specification 3/725 18/18722 0.0305779694579326 0.13866435571569 LRP2/ISL1/RBPJ 3 GO:0034134 toll-like receptor 2 signaling pathway 3/725 18/18722 0.0305779694579326 0.13866435571569 RIPK2/HMGB1/CYBA 3 GO:0044247 cellular polysaccharide catabolic process 3/725 18/18722 0.0305779694579326 0.13866435571569 AGL/GAA/HMGB1 3 GO:0048486 parasympathetic nervous system development 3/725 18/18722 0.0305779694579326 0.13866435571569 NRP2/TFAP2A/HES1 3 GO:0071360 cellular response to exogenous dsRNA 3/725 18/18722 0.0305779694579326 0.13866435571569 CAV1/COLEC12/RALB 3 GO:0099558 maintenance of synapse structure 3/725 18/18722 0.0305779694579326 0.13866435571569 DLG1/ERC1/CHCHD10 3 GO:1900006 positive regulation of dendrite development 3/725 18/18722 0.0305779694579326 0.13866435571569 BMP7/COBL/IQGAP1 3 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/725 18/18722 0.0305779694579326 0.13866435571569 DHX36/TNRC6B/AGO2 3 GO:1900424 regulation of defense response to bacterium 3/725 18/18722 0.0305779694579326 0.13866435571569 GRN/ARG2/CYBA 3 GO:0007190 activation of adenylate cyclase activity 4/725 31/18722 0.0306106557596878 0.13866435571569 LGR5/LGR4/ADRB1/CALM1 4 GO:0035115 embryonic forelimb morphogenesis 4/725 31/18722 0.0306106557596878 0.13866435571569 TBX3/RDH10/NIPBL/TFAP2A 4 GO:0046386 deoxyribose phosphate catabolic process 4/725 31/18722 0.0306106557596878 0.13866435571569 UPP1/PNP/TDG/PGM2 4 GO:0090162 establishment of epithelial cell polarity 4/725 31/18722 0.0306106557596878 0.13866435571569 RHOA/FRMD4B/CDC42/HES1 4 GO:0090183 regulation of kidney development 4/725 31/18722 0.0306106557596878 0.13866435571569 BASP1/LGR4/MAGED1/TACSTD2 4 GO:1901797 negative regulation of signal transduction by p53 class mediator 4/725 31/18722 0.0306106557596878 0.13866435571569 MIF/PTTG1IP/BCL2/MDM2 4 GO:0030516 regulation of axon extension 8/725 95/18722 0.0309406810455711 0.139660117738201 LRP1/SEMA6D/SEMA6A/MACF1/GOLGA4/SEMA4C/RAB11A/RTN4 8 GO:0036473 cell death in response to oxidative stress 8/725 95/18722 0.0309406810455711 0.139660117738201 MET/PARP1/NFE2L2/HSPB1/P4HB/BCL2/ARL6IP5/PPIA 8 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8/725 95/18722 0.0309406810455711 0.139660117738201 CAV1/SOX4/TRIM44/HMG20B/HSPA1A/UFL1/RPS20/PPIA 8 GO:1990823 response to leukemia inhibitory factor 8/725 95/18722 0.0309406810455711 0.139660117738201 NRP2/TLE4/TFRC/RPS16/B3GNT2/SRSF7/ARID5B/KDM5B 8 GO:0000723 telomere maintenance 10/725 131/18722 0.0311131742098621 0.140189048950925 MAP3K4/PRKDC/PARP1/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/NOP10 10 GO:0006612 protein targeting to membrane 10/725 131/18722 0.0311131742098621 0.140189048950925 TCAF1/NACA/STOM/HSPA5/SEC62/SIL1/HRAS/SEC61B/SEC61G/SDCBP 10 GO:0043297 apical junction assembly 7/725 78/18722 0.0312578725916781 0.140628109265269 DLG5/GJA1/RHOA/ROCK1/CLDN4/PKN2/DLG1 7 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 24/725 412/18722 0.0312661035987291 0.140628109265269 CAV1/DDB1/PSMD1/GNA12/NFE2L2/HSP90B1/SKP1/HSPA5/TBL1X/UBXN4/HERPUD1/HSPA1A/UFL1/MDM2/CCDC47/HUWE1/DDA1/DNAJB14/EIF3H/UBE2D3/SEC61B/DDIT3/UBE2A/SDCBP 24 GO:0060491 regulation of cell projection assembly 13/725 188/18722 0.0315023960199103 0.141565288497274 CAV1/KANK1/NEURL1/EPS8L1/PPP1R9A/COBL/WASF2/PFN1/CDC42/HRAS/TACSTD2/RAC1/CAPZB 13 GO:1903825 organic acid transmembrane transport 11/725 150/18722 0.0316869389692296 0.142268462032794 ITGB1/LRP2/SLC38A1/ABCB1/SLC7A6/ARL6IP5/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5 11 GO:0006984 ER-nucleus signaling pathway 5/725 46/18722 0.0318145259281097 0.142337009646591 NFE2L2/HSPA5/CCDC47/PPP1R15A/DDIT3 5 GO:0048701 embryonic cranial skeleton morphogenesis 5/725 46/18722 0.0318145259281097 0.142337009646591 GLI3/RDH10/NIPBL/TFAP2A/SETD2 5 GO:0070828 heterochromatin organization 5/725 46/18722 0.0318145259281097 0.142337009646591 MPHOSPH8/DNMT3A/HP1BP3/DNMT1/MBD3 5 GO:0072599 establishment of protein localization to endoplasmic reticulum 5/725 46/18722 0.0318145259281097 0.142337009646591 HSPA5/SEC62/HERPUD1/SEC61B/SEC61G 5 GO:0002573 myeloid leukocyte differentiation 14/725 208/18722 0.0320816675681832 0.143279271280282 FBN1/FOS/APP/TFRC/JUN/DHRS2/PARP1/RBPJ/FSTL3/GPC3/ESRRA/CEBPB/CDC42/INHA 14 GO:1901215 negative regulation of neuron death 14/725 208/18722 0.0320816675681832 0.143279271280282 LRP1/HSPD1/BTG2/ISL1/GRN/RHOA/BCL2/LGMN/CEBPB/GHR/SERPINF1/CPEB4/HRAS/RASA1 14 GO:0021537 telencephalon development 16/725 248/18722 0.0323968938872835 0.144268067125557 LRP1/ADGRG1/KIF5B/LAMB1/TACC2/BTG2/GLI3/RHOA/NF1/TRA2B/GNG12/BTBD3/HSD3B1/C12orf57/HES1/RTN4 16 GO:0046847 filopodium assembly 6/725 62/18722 0.0324169123014419 0.144268067125557 ITGB4/NEURL1/EZR/PPP1R9A/CDC42/CAPZB 6 GO:0060135 maternal process involved in female pregnancy 6/725 62/18722 0.0324169123014419 0.144268067125557 AKR1B1/GJA1/NR2F2/CTSV/ASH1L/UBE2A 6 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 6/725 62/18722 0.0324169123014419 0.144268067125557 DAG1/CTNND1/DLG1/HRAS/VAMP2/RAB11A 6 GO:0003073 regulation of systemic arterial blood pressure 8/725 96/18722 0.0326564830793103 0.144952462985135 ADRB1/GJA1/NR2F2/ENPEP/RHOA/GJA5/ATP6AP2/CYBA 8 GO:0035282 segmentation 8/725 96/18722 0.0326564830793103 0.144952462985135 NRP2/BASP1/PRKDC/TBX3/RBPJ/COBL/MIB1/IRX2 8 GO:1901655 cellular response to ketone 8/725 96/18722 0.0326564830793103 0.144952462985135 ATP2B1/AKR1B1/EGFR/LARP1/NR3C1/SERPINF1/CFLAR/FDX1 8 GO:0030178 negative regulation of Wnt signaling pathway 12/725 170/18722 0.0330348892140155 0.146503808771517 CAV1/LRP1/TLE4/ISL1/RNF43/CTNND1/ZNRF3/GLI3/GPC3/LATS2/TLE1/DDIT3 12 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 7/725 79/18722 0.0331979564813746 0.146969817820164 CUX1/PRKDC/TRIOBP/P4HB/DHX36/CDC42/RAC1 7 GO:1901184 regulation of ERBB signaling pathway 7/725 79/18722 0.0331979564813746 0.146969817820164 EGFR/NEURL1/RBPJ/LGMN/PTPN12/RTN4/CBLB 7 GO:0060326 cell chemotaxis 19/725 310/18722 0.0333366589425531 0.147455082181328 CSF3R/MIF/S100A9/DUSP1/ANXA1/MET/PGF/TMSB4X/RPS19/JAM3/PDE4B/HSPB1/LGMN/PLEC/HMGB1/SERPINE1/RAC1/FLT1/PPIA 19 GO:0045926 negative regulation of growth 16/725 249/18722 0.0334344301210224 0.147758610534841 SEMA6D/SEMA6A/ADRB1/GJA1/ENO1/SLC6A4/GPC3/SPAG9/BCL2/LGMN/HSPA1A/SERTAD2/CDKN1A/SEMA4C/RTN4/GDF15 16 GO:0003338 metanephros morphogenesis 4/725 32/18722 0.0339464491504868 0.148468119709938 BASP1/LGR4/FRAS1/HES1 4 GO:0007435 salivary gland morphogenesis 4/725 32/18722 0.0339464491504868 0.148468119709938 DAG1/LAMA5/BMP7/CDC42 4 GO:0010039 response to iron ion 4/725 32/18722 0.0339464491504868 0.148468119709938 BCL2/MDM2/TFAP2A/B2M 4 GO:0021799 cerebral cortex radially oriented cell migration 4/725 32/18722 0.0339464491504868 0.148468119709938 ADGRG1/LAMB1/GLI3/RTN4 4 GO:0033687 osteoblast proliferation 4/725 32/18722 0.0339464491504868 0.148468119709938 ITGAV/RHOA/LRP5/BCL2 4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 4/725 32/18722 0.0339464491504868 0.148468119709938 NR2F2/LATS2/CDKN1A/CDKN1C 4 GO:0050685 positive regulation of mRNA processing 4/725 32/18722 0.0339464491504868 0.148468119709938 PRDX6/HSPA8/DHX36/TRA2B 4 GO:0060323 head morphogenesis 4/725 32/18722 0.0339464491504868 0.148468119709938 ANKRD11/ARID5B/ATP6AP2/NIPBL 4 GO:0060914 heart formation 4/725 32/18722 0.0339464491504868 0.148468119709938 LRP2/ISL1/RBPJ/HES1 4 GO:0072337 modified amino acid transport 4/725 32/18722 0.0339464491504868 0.148468119709938 LRP2/GJA1/SLC6A8/SLC16A12 4 GO:0097345 mitochondrial outer membrane permeabilization 4/725 32/18722 0.0339464491504868 0.148468119709938 BNIP3L/NMT1/HSPA1A/CHCHD10 4 GO:1901185 negative regulation of ERBB signaling pathway 4/725 32/18722 0.0339464491504868 0.148468119709938 EGFR/LGMN/PTPN12/CBLB 4 GO:0046328 regulation of JNK cascade 10/725 133/18722 0.0340259245390049 0.148687423696738 APP/EGFR/GADD45B/PDCD4/PHLPP1/CDC42/HRAS/RIPK2/HMGB1/SDCBP 10 GO:0045637 regulation of myeloid cell differentiation 14/725 210/18722 0.0343783417110266 0.149766771776526 FBN1/CSF3R/FOS/JUN/PRKDC/FSTL3/ESRRA/CEBPB/HSPA1A/RCOR1/FAM210B/INHA/HMGB1/B2M 14 GO:0031056 regulation of histone modification 11/725 152/18722 0.0344216181917015 0.149766771776526 IGF2/BRD4/ISL1/ATRX/ZNF451/BRD7/NIPBL/KDM5A/RTF1/EID1/DNMT1 11 GO:0051092 positive regulation of NF-kappaB transcription factor activity 11/725 152/18722 0.0344216181917015 0.149766771776526 CAV1/APP/TFRC/S100A9/NPM1/HSPA1A/CAT/ERC1/CFLAR/RIPK2/PPIA 11 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 8/725 97/18722 0.0344359918894758 0.149766771776526 ITGAV/ITGA6/BCL2/HSPA1A/BIRC6/CFLAR/SERPINE1/TMBIM1 8 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 5/725 47/18722 0.0345092896892843 0.149766771776526 ADRB1/ENPEP/RHOA/ATP6AP2/CYBA 5 GO:0010761 fibroblast migration 5/725 47/18722 0.0345092896892843 0.149766771776526 ITGB1/GNA12/ARID5B/PLEC/RAC1 5 GO:0016574 histone ubiquitination 5/725 47/18722 0.0345092896892843 0.149766771776526 DDB1/SKP1/USP22/HUWE1/UBE2A 5 GO:0048483 autonomic nervous system development 5/725 47/18722 0.0345092896892843 0.149766771776526 NRP2/SOX4/NF1/TFAP2A/HES1 5 GO:0030278 regulation of ossification 9/725 115/18722 0.0345787735980547 0.149939951555636 ATP2B1/FBN2/RBPJ/PBX1/BMP7/ESRRA/BCL2/NIPBL/TFAP2A 9 GO:0030239 myofibril assembly 6/725 63/18722 0.0347025472556272 0.150348044477585 KRT19/KRT8/ITGB1/ACTG1/PLEC/CFLAR 6 GO:0120193 tight junction organization 7/725 80/18722 0.0352166393864144 0.151996901175461 SVEP1/GJA1/ACTG1/ROCK1/CLDN4/PLEC/DLG1 7 GO:0016311 dephosphorylation 24/725 417/18722 0.035242584145387 0.151996901175461 PLPP3/SLC39A10/DUSP1/CTDSPL/CALM1/DUSP6/HSP90B1/LPIN2/PTPRA/PHLPP1/CSNK2B/TNS3/ROCK1/BCL2/PTPN14/BOD1L1/CAMK2G/DLG1/PPP6R2/PTPN12/PPP1R15A/PTPRF/PHPT1/PPIA 24 GO:0006491 N-glycan processing 3/725 19/18722 0.0352930267673146 0.151996901175461 GANAB/MAN1A2/FUT8 3 GO:0010002 cardioblast differentiation 3/725 19/18722 0.0352930267673146 0.151996901175461 ISL1/RBPJ/DHX36 3 GO:0030011 maintenance of cell polarity 3/725 19/18722 0.0352930267673146 0.151996901175461 DLG5/DST/SLC9A1 3 GO:0060065 uterus development 3/725 19/18722 0.0352930267673146 0.151996901175461 ASH1L/NIPBL/KDM5B 3 GO:1900221 regulation of amyloid-beta clearance 3/725 19/18722 0.0352930267673146 0.151996901175461 LRP1/LRPAP1/ROCK1 3 GO:0019693 ribose phosphate metabolic process 23/725 396/18722 0.0354433870809078 0.152514880401631 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/UPP1/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/RPIA/DLG1/HINT1/MPC2/AK3/RFK 23 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 10/725 134/18722 0.0355514981748676 0.1528503343922 CAV1/GNA12/NFE2L2/HERPUD1/HSPA1A/UFL1/MDM2/DDA1/EIF3H/SDCBP 10 GO:0007006 mitochondrial membrane organization 9/725 116/18722 0.0362568518329415 0.155586880978232 PMAIP1/CALM1/BNIP3L/NMT1/BCL2/AFG3L2/HSPA1A/SLC9A1/CHCHD10 9 GO:0043473 pigmentation 8/725 98/18722 0.0362800736469266 0.155586880978232 CD63/GLI3/NF1/BCL2/ATP6AP2/MFSD12/RAB11A/RAB1A 8 GO:1902882 regulation of response to oxidative stress 8/725 98/18722 0.0362800736469266 0.155586880978232 MET/PARP1/NFE2L2/HSPB1/BMP7/P4HB/FUT8/PPIA 8 GO:0055002 striated muscle cell development 6/725 64/18722 0.0370895531914883 0.158655649896755 KRT19/KRT8/ITGB1/ACTG1/PLEC/CFLAR 6 GO:0098930 axonal transport 6/725 64/18722 0.0370895531914883 0.158655649896755 ARMCX3/KIF5B/DST/DYNC1H1/HSPB1/ARL8B 6 GO:1900076 regulation of cellular response to insulin stimulus 6/725 64/18722 0.0370895531914883 0.158655649896755 ATP2B1/IGF2/KANK1/SOCS1/ESRRA/PIP4K2A 6 GO:0001942 hair follicle development 7/725 81/18722 0.0373149452977935 0.159082807161073 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NUMA1 7 GO:0006096 glycolytic process 7/725 81/18722 0.0373149452977935 0.159082807161073 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1 7 GO:0010833 telomere maintenance via telomere lengthening 7/725 81/18722 0.0373149452977935 0.159082807161073 MAP3K4/PARP1/PKIB/DHX36/RAD50/HNRNPA1/NOP10 7 GO:1903533 regulation of protein targeting 7/725 81/18722 0.0373149452977935 0.159082807161073 TCAF1/STOM/LMAN1/BNIP3L/HUWE1/HRAS/UBE2D3 7 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 4/725 33/18722 0.0374853282967323 0.15954083050893 ZNF451/DHX36/HMGB1/SUB1 4 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 4/725 33/18722 0.0374853282967323 0.15954083050893 NR2F2/LATS2/CDKN1A/CDKN1C 4 GO:0001935 endothelial cell proliferation 13/725 193/18722 0.037732581267086 0.160458434935285 NRP2/CAV1/IGF2/GJA1/NR2F2/PGF/PDCD6/NF1/APELA/DLG1/HMGB1/FLT1/CYBA 13 GO:0050867 positive regulation of cell activation 24/725 420/18722 0.0378037942866741 0.160626515707587 CAV1/IGF2/CD46/MIF/TFRC/JUND/SLC39A10/HSPD1/CTSC/PRKDC/ANXA1/PNP/SOX4/GLI3/IL6ST/RHOA/SOCS1/BCL2/CD55/CDKN1A/HES1/RIPK2/HMGB1/B2M 24 GO:0060996 dendritic spine development 8/725 99/18722 0.038189551939739 0.162129680722393 DLG5/NEURL1/PPP1R9A/DHX36/CFL1/CDC42/ARF4/ARF1 8 GO:0010970 transport along microtubule 11/725 155/18722 0.0388293938547044 0.164432913491643 ARMCX3/APP/KIF5B/HSPA8/DST/DYNC1H1/HSPB1/CDC42/PURA/RAB1A/ARL8B 11 GO:0034614 cellular response to reactive oxygen species 11/725 155/18722 0.0388293938547044 0.164432913491643 FOS/JUN/SOD3/EGFR/ANXA1/MET/NFE2L2/BMP7/MDM2/RHOB/NET1 11 GO:1903364 positive regulation of cellular protein catabolic process 11/725 155/18722 0.0388293938547044 0.164432913491643 CAV1/LRP1/LRP2/CTSC/NFE2L2/EZR/PTTG1IP/HERPUD1/HSPA1A/MDM2/DDA1 11 GO:0048588 developmental cell growth 15/725 234/18722 0.0392727294496378 0.166171507162115 NRP2/ITGB1/LRP1/SEMA6D/APP/SEMA6A/MACF1/GOLGA4/COBL/SPAG9/IQGAP1/USP9X/SEMA4C/RAB11A/RTN4 15 GO:0006757 ATP generation from ADP 7/725 82/18722 0.0394938290378084 0.166408590264874 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1 7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 7/725 82/18722 0.0394938290378084 0.166408590264874 PMAIP1/BCL2/CFLAR/SERPINE1/TMBIM1/ATF3/TIMP3 7 GO:0070936 protein K48-linked ubiquitination 6/725 65/18722 0.0395790673608438 0.166408590264874 SKP1/TRIM44/TTC3/UBE2D3/PPIA/UBE2A 6 GO:0090307 mitotic spindle assembly 6/725 65/18722 0.0395790673608438 0.166408590264874 RHOA/HSPA1A/KPNB1/STAG1/RAB11A/CCSAP 6 GO:1902475 L-alpha-amino acid transmembrane transport 6/725 65/18722 0.0395790673608438 0.166408590264874 ITGB1/SLC38A1/SLC7A6/ARL6IP5/SLC38A9/SLC7A5 6 GO:0030203 glycosaminoglycan metabolic process 9/725 118/18722 0.0397784984830835 0.166408590264874 ITIH5/GNS/B3GNT2/CLTC/HEXA/BGN/B3GAT3/CHST12/GLCE 9 GO:1903313 positive regulation of mRNA metabolic process 9/725 118/18722 0.0397784984830835 0.166408590264874 PRDX6/HSPA8/BTG2/DHX36/TRA2B/ROCK1/PUM1/TNRC6B/AGO2 9 GO:0042110 T cell activation 27/725 487/18722 0.0398490387363373 0.166408590264874 CAV1/IGF2/DLG5/CD46/TFRC/HSPD1/PRKDC/RPS6/ANXA1/PNP/SOX4/GLI3/IL6ST/CTSL/RHOA/SOCS1/BCL2/RPL22/CEBPB/DLG1/CD55/HES1/RIPK2/HMGB1/ARG2/B2M/CBLB 27 GO:0050890 cognition 18/725 296/18722 0.0400911552538256 0.166408590264874 ITGB1/FOS/APP/JUN/EGFR/BTG2/NF1/SLC6A4/LGMN/CEBPB/ARL6IP5/NIPBL/SERPINF1/C12orf57/ARF4/SGK1/PAIP2/B2M 18 GO:0061640 cytoskeleton-dependent cytokinesis 8/725 100/18722 0.0401652065841823 0.166408590264874 SON/MYH10/RHOA/ROCK1/PLEC/RHOB/RASA1/ARF1 8 GO:0007611 learning or memory 16/725 255/18722 0.040176163009859 0.166408590264874 ITGB1/FOS/APP/JUN/EGFR/BTG2/NF1/SLC6A4/LGMN/CEBPB/ARL6IP5/SERPINF1/ARF4/SGK1/PAIP2/B2M 16 GO:1903362 regulation of cellular protein catabolic process 16/725 255/18722 0.040176163009859 0.166408590264874 CAV1/LRP1/LRP2/CTSC/GNA12/NFE2L2/EZR/PTTG1IP/HERPUD1/HSPA1A/UFL1/MDM2/DDA1/MYLIP/EIF3H/SDCBP 16 GO:0009409 response to cold 5/725 49/18722 0.0403113812073727 0.166408590264874 ATP2B1/FOS/HSPD1/ADRB1/SLC9A1 5 GO:0035088 establishment or maintenance of apical/basal cell polarity 5/725 49/18722 0.0403113812073727 0.166408590264874 DLG5/RHOA/DLG1/CDC42/ARF4 5 GO:0043330 response to exogenous dsRNA 5/725 49/18722 0.0403113812073727 0.166408590264874 CAV1/COLEC12/DHX36/RALB/RIPK2 5 GO:0045778 positive regulation of ossification 5/725 49/18722 0.0403113812073727 0.166408590264874 ATP2B1/FBN2/BMP7/NIPBL/TFAP2A 5 GO:0046580 negative regulation of Ras protein signal transduction 5/725 49/18722 0.0403113812073727 0.166408590264874 ITGB1/KANK1/MET/RASA1/TIMP2 5 GO:0060986 endocrine hormone secretion 5/725 49/18722 0.0403113812073727 0.166408590264874 GJA1/TBX3/RAB11FIP1/C1QTNF1/INHA 5 GO:0061245 establishment or maintenance of bipolar cell polarity 5/725 49/18722 0.0403113812073727 0.166408590264874 DLG5/RHOA/DLG1/CDC42/ARF4 5 GO:0070169 positive regulation of biomineral tissue development 5/725 49/18722 0.0403113812073727 0.166408590264874 ATP2B1/FBN2/BMP7/CEBPB/TFAP2A 5 GO:0070849 response to epidermal growth factor 5/725 49/18722 0.0403113812073727 0.166408590264874 EEF1A1/EGFR/IQGAP1/PTPN12/CFLAR 5 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 5/725 49/18722 0.0403113812073727 0.166408590264874 JUN/GJA1/ADAMTS1/MDM2/DNMT1 5 GO:1904894 positive regulation of receptor signaling pathway via STAT 5/725 49/18722 0.0403113812073727 0.166408590264874 AKR1B1/CSH1/SOCS1/GHR/HES1 5 GO:0000272 polysaccharide catabolic process 3/725 20/18722 0.0403593654928414 0.166408590264874 AGL/GAA/HMGB1 3 GO:0006607 NLS-bearing protein import into nucleus 3/725 20/18722 0.0403593654928414 0.166408590264874 RANBP2/KPNB1/CBLB 3 GO:0042359 vitamin D metabolic process 3/725 20/18722 0.0403593654928414 0.166408590264874 LRP2/CYP11A1/LGMN 3 GO:0045063 T-helper 1 cell differentiation 3/725 20/18722 0.0403593654928414 0.166408590264874 ANXA1/RIPK2/HMGB1 3 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/725 20/18722 0.0403593654928414 0.166408590264874 NFE2L2/HSPB1/PPIA 3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/725 20/18722 0.0403593654928414 0.166408590264874 HERPUD1/HSPA1A/GRINA 3 GO:1904292 regulation of ERAD pathway 3/725 20/18722 0.0403593654928414 0.166408590264874 CAV1/NFE2L2/HERPUD1 3 GO:2000678 negative regulation of transcription regulatory region DNA binding 3/725 20/18722 0.0403593654928414 0.166408590264874 TMSB4X/DDIT3/SRI 3 GO:0010977 negative regulation of neuron projection development 10/725 137/18722 0.0404121078350878 0.166408590264874 LRP1/KANK1/SEMA6D/SEMA6A/RHOA/MDM2/MYLIP/SEMA4C/RTN4/B2M 10 GO:0090090 negative regulation of canonical Wnt signaling pathway 10/725 137/18722 0.0404121078350878 0.166408590264874 CAV1/TLE4/ISL1/CTNND1/ZNRF3/GLI3/GPC3/LATS2/TLE1/DDIT3 10 GO:0030705 cytoskeleton-dependent intracellular transport 13/725 195/18722 0.0404543526431985 0.166447332425628 ARMCX3/SYNE2/APP/KIF5B/HSPA8/DST/DYNC1H1/HSPB1/HOOK3/CDC42/PURA/RAB1A/ARL8B 13 GO:2000116 regulation of cysteine-type endopeptidase activity 15/725 235/18722 0.040520544684358 0.166584461480138 SERPINB9/PMAIP1/S100A9/DHCR24/HSPD1/PDCD6/RHOA/LGMN/HERPUD1/ARL6IP5/MDM2/ASPH/CFLAR/RIPK2/HMGB1 15 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 4/725 34/18722 0.0412279169076646 0.16880800549673 CTSL/CTSV/LGMN/B2M 4 GO:0032743 positive regulation of interleukin-2 production 4/725 34/18722 0.0412279169076646 0.16880800549673 ANXA1/PNP/PDE4B/RIPK2 4 GO:0043276 anoikis 4/725 34/18722 0.0412279169076646 0.16880800549673 CAV1/ITGB1/BCL2/TLE1 4 GO:0048261 negative regulation of receptor-mediated endocytosis 4/725 34/18722 0.0412279169076646 0.16880800549673 ITGAV/LRPAP1/RAC1/SDCBP 4 GO:1990000 amyloid fibril formation 4/725 34/18722 0.0412279169076646 0.16880800549673 APP/MDM2/USP9X/B2M 4 GO:0010906 regulation of glucose metabolic process 9/725 119/18722 0.0416233622152626 0.170289606996906 IGF2/PMAIP1/DDB1/PHLDA2/SLC35B4/RANBP2/C1QTNF1/NCOA2/HMGB1 9 GO:0031397 negative regulation of protein ubiquitination 7/725 83/18722 0.0417541748277487 0.170687025969241 CAV1/SOX4/TRIM44/HSPA1A/UFL1/RPS20/PPIA 7 GO:1990845 adaptive thermogenesis 11/725 157/18722 0.0419775126769511 0.171341665700368 CAV1/LGR4/ADRB1/GJA1/RBPJ/ARRDC3/SCD/DYNC1H1/CEBPB/DDIT3/ESRRG 11 GO:0046034 ATP metabolic process 17/725 277/18722 0.0419819192739904 0.171341665700368 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/HSPA8/PARP1/TMSB4X/RHOA/ENO1/HSPA1A/COX6A1/UQCRH/CHCHD2/SDHA/CHCHD10 17 GO:0019229 regulation of vasoconstriction 6/725 66/18722 0.0421721055735286 0.171841160090206 ATP2B1/CAV1/EGFR/GJA1/RHOA/GJA5 6 GO:0042446 hormone biosynthetic process 6/725 66/18722 0.0421721055735286 0.171841160090206 CYP11A1/AKR1B1/HSD3B1/HSD17B1/CYP19A1/FDX1 6 GO:0031349 positive regulation of defense response 17/725 278/18722 0.0431817064164165 0.175813710702663 NEAT1/APP/S100A9/HSPD1/CTSC/PRKDC/EGFR/GJA1/PDCD4/GRN/IL6ST/RPS19/CEBPB/RIPK2/HMGB1/SERPINE1/CYBA 17 GO:0018023 peptidyl-lysine trimethylation 5/725 50/18722 0.0434209045899548 0.175939700532759 BRD4/TET2/ATRX/RTF1/SETD2 5 GO:0030490 maturation of SSU-rRNA 5/725 50/18722 0.0434209045899548 0.175939700532759 RPS21/RPS16/RPS8/RPS19/SNU13 5 GO:0060425 lung morphogenesis 5/725 50/18722 0.0434209045899548 0.175939700532759 DLG5/DAG1/RDH10/SRSF6/CDC42 5 GO:0060688 regulation of morphogenesis of a branching structure 5/725 50/18722 0.0434209045899548 0.175939700532759 LGR4/MAGED1/BMP7/TACSTD2/RTN4 5 GO:0110151 positive regulation of biomineralization 5/725 50/18722 0.0434209045899548 0.175939700532759 ATP2B1/FBN2/BMP7/CEBPB/TFAP2A 5 GO:1903747 regulation of establishment of protein localization to mitochondrion 5/725 50/18722 0.0434209045899548 0.175939700532759 LMAN1/BNIP3L/NMT1/HUWE1/UBE2D3 5 GO:0030216 keratinocyte differentiation 10/725 139/18722 0.043894590223328 0.17771699508151 ANXA1/RBPJ/TXNIP/OPN3/ROCK1/NCOA3/PLEC/FLNB/SRSF6/NUMA1 10 GO:0022404 molting cycle process 7/725 84/18722 0.0440967950165484 0.177967081161532 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NUMA1 7 GO:0022405 hair cycle process 7/725 84/18722 0.0440967950165484 0.177967081161532 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NUMA1 7 GO:0042310 vasoconstriction 7/725 84/18722 0.0440967950165484 0.177967081161532 ATP2B1/CAV1/EGFR/GJA1/RHOA/SLC6A4/GJA5 7 GO:0097061 dendritic spine organization 7/725 84/18722 0.0440967950165484 0.177967081161532 PPP1R9A/HOMER1/DHX36/LGMN/CFL1/CDC42/ARF1 7 GO:0032677 regulation of interleukin-8 production 8/725 102/18722 0.0443179387713988 0.178717288490231 ANXA4/ANXA1/TMSB4X/HSPA1A/DDIT3/HMGB1/RAB1A/SERPINE1 8 GO:1902105 regulation of leukocyte differentiation 17/725 279/18722 0.0444058948578352 0.178929635162454 FBN1/FOS/CD46/JUN/PRKDC/ANXA1/FSTL3/PNP/SOX4/GLI3/RHOA/SOCS1/ESRRA/CEBPB/INHA/RIPK2/HMGB1 17 GO:0009266 response to temperature stimulus 12/725 178/18722 0.0444512512728308 0.178970129231119 ATP2B1/FOS/HSPD1/ADRB1/PDCD6/SLC52A3/DHX36/HSPA1A/SLC9A1/ERO1A/DNAJB4/CDKN1A 12 GO:0006513 protein monoubiquitination 6/725 67/18722 0.0448695610959299 0.179717096213764 DDB1/NEURL1/PDCD6/SKP1/HUWE1/UBE2D3 6 GO:0035914 skeletal muscle cell differentiation 6/725 67/18722 0.0448695610959299 0.179717096213764 FOS/DDX5/BTG2/HMG20B/DDX17/ATF3 6 GO:0061180 mammary gland epithelium development 6/725 67/18722 0.0448695610959299 0.179717096213764 TBX3/LRP5/CEBPB/KDM5B/RTN4/ZNF703 6 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 6/725 67/18722 0.0448695610959299 0.179717096213764 ANXA1/SOCS1/CD55/RIPK2/HMGB1/ARG2 6 GO:0001893 maternal placenta development 4/725 35/18722 0.0451743255836979 0.179717096213764 GJA1/NR2F2/CTSV/ASH1L 4 GO:0010664 negative regulation of striated muscle cell apoptotic process 4/725 35/18722 0.0451743255836979 0.179717096213764 NFE2L2/BMP7/PPP1R10/CFLAR 4 GO:0010765 positive regulation of sodium ion transport 4/725 35/18722 0.0451743255836979 0.179717096213764 KIF5B/SLC9A1/ARF1/GLRX 4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 4/725 35/18722 0.0451743255836979 0.179717096213764 ISL1/PARP1/UFL1/UBA5 4 GO:0034331 cell junction maintenance 4/725 35/18722 0.0451743255836979 0.179717096213764 DLG1/MTSS1/ERC1/CHCHD10 4 GO:0046640 regulation of alpha-beta T cell proliferation 4/725 35/18722 0.0451743255836979 0.179717096213764 CD55/RIPK2/ARG2/CBLB 4 GO:0086005 ventricular cardiac muscle cell action potential 4/725 35/18722 0.0451743255836979 0.179717096213764 CAV1/DSG2/DLG1/DSC2 4 GO:1905508 protein localization to microtubule organizing center 4/725 35/18722 0.0451743255836979 0.179717096213764 GOLGB1/HOOK3/CEP350/NUMA1 4 GO:0009259 ribonucleotide metabolic process 22/725 385/18722 0.0452651480709358 0.179717096213764 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/UPP1/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3/RFK 22 GO:0051170 import into nucleus 11/725 159/18722 0.0452976012395222 0.179717096213764 CDH1/TXNIP/PTTG1IP/GLI3/PPP1R10/HNRNPA1/TNPO1/RANBP2/KPNB1/CDKN1A/CBLB 11 GO:0042752 regulation of circadian rhythm 9/725 121/18722 0.0454841792173063 0.179717096213764 PRKDC/DDB1/MAGED1/ADRB1/ZFHX3/OPN3/PHLPP1/GNAQ/USP9X 9 GO:0050768 negative regulation of neurogenesis 10/725 140/18722 0.0457099910086546 0.179717096213764 SEMA6D/SEMA6A/NF1/BMP7/HOOK3/DICER1/HES1/SEMA4C/RTN4/B2M 10 GO:0006925 inflammatory cell apoptotic process 3/725 21/18722 0.045771310162156 0.179717096213764 ANXA1/CTSL/PIK3CB 3 GO:0007350 blastoderm segmentation 3/725 21/18722 0.045771310162156 0.179717096213764 NRP2/BASP1/TBX3 3 GO:0008090 retrograde axonal transport 3/725 21/18722 0.045771310162156 0.179717096213764 KIF5B/DST/DYNC1H1 3 GO:0032288 myelin assembly 3/725 21/18722 0.045771310162156 0.179717096213764 ITGB4/DICER1/EPB41L3 3 GO:0032516 positive regulation of phosphoprotein phosphatase activity 3/725 21/18722 0.045771310162156 0.179717096213764 SLC39A10/CALM1/PPP1R15A 3 GO:0038083 peptidyl-tyrosine autophosphorylation 3/725 21/18722 0.045771310162156 0.179717096213764 CAV1/EGFR/IQGAP1 3 GO:0048485 sympathetic nervous system development 3/725 21/18722 0.045771310162156 0.179717096213764 NRP2/SOX4/NF1 3 GO:0048745 smooth muscle tissue development 3/725 21/18722 0.045771310162156 0.179717096213764 NF1/DLG1/ENG 3 GO:0060445 branching involved in salivary gland morphogenesis 3/725 21/18722 0.045771310162156 0.179717096213764 DAG1/LAMA5/BMP7 3 GO:0072111 cell proliferation involved in kidney development 3/725 21/18722 0.045771310162156 0.179717096213764 BMP7/GPC3/CFLAR 3 GO:0090026 positive regulation of monocyte chemotaxis 3/725 21/18722 0.045771310162156 0.179717096213764 LGMN/HMGB1/SERPINE1 3 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 3/725 21/18722 0.045771310162156 0.179717096213764 LGR4/MAGED1/TACSTD2 3 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3/725 21/18722 0.045771310162156 0.179717096213764 NMT1/HSPA1A/CHCHD10 3 GO:1902473 regulation of protein localization to synapse 3/725 21/18722 0.045771310162156 0.179717096213764 DAG1/DLG1/HRAS 3 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 3/725 21/18722 0.045771310162156 0.179717096213764 HSPD1/RHOA/CFLAR 3 GO:2000774 positive regulation of cellular senescence 3/725 21/18722 0.045771310162156 0.179717096213764 YPEL3/ARG2/B2M 3 GO:0001936 regulation of endothelial cell proliferation 12/725 179/18722 0.0460487474263286 0.180666486613049 NRP2/CAV1/IGF2/GJA1/NR2F2/PGF/PDCD6/NF1/APELA/HMGB1/FLT1/CYBA 12 GO:0097191 extrinsic apoptotic signaling pathway 14/725 219/18722 0.0461933858614121 0.181093791903711 KRT8/CAV1/ITGAV/PMAIP1/KRT18/ITGA6/BCL2/HSPA1A/BIRC6/CFLAR/SERPINE1/TMBIM1/ATF3/TIMP3 14 GO:0032637 interleukin-8 production 8/725 103/18722 0.046496347532632 0.181142967449448 ANXA4/ANXA1/TMSB4X/HSPA1A/DDIT3/HMGB1/RAB1A/SERPINE1 8 GO:0032760 positive regulation of tumor necrosis factor production 8/725 103/18722 0.046496347532632 0.181142967449448 MIF/APP/HSPD1/ISL1/HSPB1/RIPK2/HMGB1/CYBA 8 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 7/725 85/18722 0.0465224289693748 0.181142967449448 CAV1/ISL1/CSH1/IL6ST/SOCS1/GHR/HES1 7 GO:0060021 roof of mouth development 7/725 85/18722 0.0465224289693748 0.181142967449448 TGFBR3/TBX3/GLI3/FRAS1/ARID5B/DLG1/TFAP2A 7 GO:0098773 skin epidermis development 7/725 85/18722 0.0465224289693748 0.181142967449448 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NUMA1 7 GO:0009948 anterior/posterior axis specification 5/725 51/18722 0.0466704903312249 0.181142967449448 WLS/BASP1/TBX3/GPC3/DDIT3 5 GO:0010656 negative regulation of muscle cell apoptotic process 5/725 51/18722 0.0466704903312249 0.181142967449448 NFE2L2/BMP7/PPP1R10/DNMT1/CFLAR 5 GO:0014009 glial cell proliferation 5/725 51/18722 0.0466704903312249 0.181142967449448 EGFR/SOX4/DICER1/UFL1/HES1 5 GO:0021872 forebrain generation of neurons 5/725 51/18722 0.0466704903312249 0.181142967449448 NRP2/GLI3/RHOA/HES1/B2M 5 GO:0032873 negative regulation of stress-activated MAPK cascade 5/725 51/18722 0.0466704903312249 0.181142967449448 DUSP1/PDCD4/EZR/DLG1/PPIA 5 GO:0046850 regulation of bone remodeling 5/725 51/18722 0.0466704903312249 0.181142967449448 TFRC/EGFR/NF1/SUCO/SYT7 5 GO:0065002 intracellular protein transmembrane transport 5/725 51/18722 0.0466704903312249 0.181142967449448 HSPD1/HSPA5/SEC62/SEC61B/SEC61G 5 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 5/725 51/18722 0.0466704903312249 0.181142967449448 DUSP1/PDCD4/EZR/DLG1/PPIA 5 GO:0032886 regulation of microtubule-based process 15/725 240/18722 0.0471864411736554 0.183005409570971 AKAP9/CLIP1/MET/MACF1/RHOA/NPM1/DYNC1H1/ROCK1/CLTC/HSPA1A/GPSM2/PHLDB2/NUMA1/CCSAP/RAC1 15 GO:0050868 negative regulation of T cell activation 9/725 122/18722 0.0475012409266326 0.183951194192111 DLG5/ANXA1/GLI3/SOCS1/CEBPB/DLG1/HMGB1/ARG2/CBLB 9 GO:0035296 regulation of tube diameter 10/725 141/18722 0.0475754617450892 0.183951194192111 ATP2B1/CAV1/SOD3/EGFR/ADRB1/GJA1/RHOA/SLC6A4/ROCK1/GJA5 10 GO:0048284 organelle fusion 10/725 141/18722 0.0475754617450892 0.183951194192111 TFRC/KIF5B/ANXA1/AFG3L2/SYT7/HUWE1/UVRAG/PIP4K2A/VAMP2/ARL8B 10 GO:0097746 blood vessel diameter maintenance 10/725 141/18722 0.0475754617450892 0.183951194192111 ATP2B1/CAV1/SOD3/EGFR/ADRB1/GJA1/RHOA/SLC6A4/ROCK1/GJA5 10 GO:0031503 protein-containing complex localization 14/725 220/18722 0.047662038703444 0.184044479412663 AKAP9/DAG1/KIF5B/EZR/NPM1/PABPN1/DLG1/RALB/PURA/HRAS/UPF2/SETD2/VAMP2/RAB11A 14 GO:0061912 selective autophagy 6/725 68/18722 0.0476722038802184 0.184044479412663 HSPB8/UFL1/UBA5/HUWE1/RIPK2/MAP1LC3B 6 GO:0071902 positive regulation of protein serine/threonine kinase activity 13/725 200/18722 0.0478583570727008 0.184622535769803 IGF2/MAP3K4/MAGED1/EGFR/CALM1/RHOA/GHR/IQGAP1/RALB/SASH1/HRAS/ERP29/FLT1 13 GO:0008544 epidermis development 19/725 324/18722 0.0483488158212311 0.186372735663742 SVEP1/LGR5/LGR4/EGFR/LAMA5/ANXA1/RBPJ/TRIOBP/TXNIP/OPN3/ROCK1/NCOA3/BCL2/PLEC/FLNB/SRSF6/HES1/NUMA1/YBX1 19 GO:0048661 positive regulation of smooth muscle cell proliferation 8/725 104/18722 0.0487435932814249 0.187751728224576 JUN/AKR1B1/EGFR/GJA1/ADAMTS1/MDM2/DNMT1/CYBA 8 GO:0034103 regulation of tissue remodeling 7/725 86/18722 0.0490317421146962 0.188432070340709 TFRC/EGFR/NF1/SUCO/ROCK1/SYT7/TMBIM1 7 GO:0035023 regulation of Rho protein signal transduction 7/725 86/18722 0.0490317421146962 0.188432070340709 ITGB1/ADGRG1/KANK1/MET/EPS8L1/NET1/RAC1 7 GO:1903510 mucopolysaccharide metabolic process 7/725 86/18722 0.0490317421146962 0.188432070340709 ITIH5/GNS/B3GNT2/CLTC/BGN/CHST12/GLCE 7 GO:0008207 C21-steroid hormone metabolic process 4/725 36/18722 0.0493241711306968 0.188697527140756 CYP11A1/AKR1B1/DHRS2/HSD3B1 4 GO:0009225 nucleotide-sugar metabolic process 4/725 36/18722 0.0493241711306968 0.188697527140756 UGP2/EXTL2/NANS/FUT8 4 GO:0010092 specification of animal organ identity 4/725 36/18722 0.0493241711306968 0.188697527140756 LRP2/ISL1/RBPJ/GLI3 4 GO:0060251 regulation of glial cell proliferation 4/725 36/18722 0.0493241711306968 0.188697527140756 EGFR/DICER1/UFL1/HES1 4 GO:0090322 regulation of superoxide metabolic process 4/725 36/18722 0.0493241711306968 0.188697527140756 EGFR/NFE2L2/BMP7/CYBA 4 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 4/725 36/18722 0.0493241711306968 0.188697527140756 TPT1/MIF/RPL26/BCL2 4 GO:0008361 regulation of cell size 12/725 181/18722 0.0493615372534827 0.188698063603246 LRP1/SEMA6D/SEMA6A/KCNN4/MACF1/GOLGA4/RHOA/NPM1/SEMA4C/RAB11A/RTN4/RAC1 12 GO:0035150 regulation of tube size 10/725 142/18722 0.0494914457027067 0.189052101180874 ATP2B1/CAV1/SOD3/EGFR/ADRB1/GJA1/RHOA/SLC6A4/ROCK1/GJA5 10 GO:0071482 cellular response to light stimulus 9/725 123/18722 0.0495767559503877 0.189235373428099 DDB1/PARP1/RPL26/OPN3/NPM1/NMT1/DHX36/MDM2/CDKN1A 9 GO:0010718 positive regulation of epithelial to mesenchymal transition 5/725 52/18722 0.0500606596297485 0.190080512107262 ISL1/BMP7/ZNF703/ENG/SDCBP 5 GO:0030514 negative regulation of BMP signaling pathway 5/725 52/18722 0.0500606596297485 0.190080512107262 FBN1/LRP2/FSTL3/CRIM1/UBE2D3 5 GO:0035196 production of miRNAs involved in gene silencing by miRNA 5/725 52/18722 0.0500606596297485 0.190080512107262 EGFR/DDX5/DICER1/PUM1/AGO2 5 GO:0043277 apoptotic cell clearance 5/725 52/18722 0.0500606596297485 0.190080512107262 LRP1/ITGAV/ANXA1/HMGB1/RAC1 5 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 5/725 52/18722 0.0500606596297485 0.190080512107262 ZNRF3/RHOA/GPC3/CDC42/RAC1 5 GO:1903426 regulation of reactive oxygen species biosynthetic process 5/725 52/18722 0.0500606596297485 0.190080512107262 HSPD1/RHOA/CFLAR/ARG2/CYBA 5 GO:2000378 negative regulation of reactive oxygen species metabolic process 5/725 52/18722 0.0500606596297485 0.190080512107262 HSPD1/RHOA/BCL2/TFAP2A/CFLAR 5 GO:0015807 L-amino acid transport 6/725 69/18722 0.0505806801139745 0.19158281897397 ITGB1/SLC38A1/SLC7A6/ARL6IP5/SLC38A9/SLC7A5 6 GO:0034605 cellular response to heat 6/725 69/18722 0.0505806801139745 0.19158281897397 HSPD1/PDCD6/SLC52A3/DHX36/HSPA1A/CDKN1A 6 GO:0060193 positive regulation of lipase activity 6/725 69/18722 0.0505806801139745 0.19158281897397 EGFR/RHOA/GNAQ/HRAS/ARF4/FLT1 6 GO:0051494 negative regulation of cytoskeleton organization 11/725 162/18722 0.0506074954835561 0.19158281897397 KANK1/MET/TRIOBP/TMSB4X/PPP1R9A/NPM1/WASF2/PHLDB2/PFN1/TACSTD2/CAPZB 11 GO:1901987 regulation of cell cycle phase transition 22/725 390/18722 0.0507828472901865 0.192103173816385 BRD4/APP/PRKDC/DUSP1/DDB1/EGFR/CTDSPL/ANXA1/SOX4/RPL26/PBX1/NPM1/ADAMTS1/BRD7/PPP1R10/BCL2/DLG1/MDM2/NEK6/CDKN1A/RAB11A/CENPF 22 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 8/725 105/18722 0.0510602220175613 0.192864579289879 NEURL1/EPS8L1/COBL/WASF2/PFN1/CDC42/HRAS/RAC1 8 GO:2001022 positive regulation of response to DNA damage stimulus 8/725 105/18722 0.0510602220175613 0.192864579289879 FUS/PMAIP1/PRKDC/EGFR/DDX5/PARP1/RPL26/HMGB1 8 GO:0032069 regulation of nuclease activity 3/725 22/18722 0.0515219973401616 0.193270881222372 NPM1/HSPA1A/HMGB1 3 GO:0035024 negative regulation of Rho protein signal transduction 3/725 22/18722 0.0515219973401616 0.193270881222372 ITGB1/KANK1/MET 3 GO:0048026 positive regulation of mRNA splicing, via spliceosome 3/725 22/18722 0.0515219973401616 0.193270881222372 PRDX6/HSPA8/TRA2B 3 GO:0050860 negative regulation of T cell receptor signaling pathway 3/725 22/18722 0.0515219973401616 0.193270881222372 EZR/PHPT1/CBLB 3 GO:0051220 cytoplasmic sequestering of protein 3/725 22/18722 0.0515219973401616 0.193270881222372 TMSB4X/GOPC/SRI 3 GO:0055093 response to hyperoxia 3/725 22/18722 0.0515219973401616 0.193270881222372 CAV1/CAT/CDKN1A 3 GO:0060343 trabecula formation 3/725 22/18722 0.0515219973401616 0.193270881222372 FBN2/TGFBR3/ADAMTS1 3 GO:0060444 branching involved in mammary gland duct morphogenesis 3/725 22/18722 0.0515219973401616 0.193270881222372 TBX3/LRP5/KDM5B 3 GO:1900120 regulation of receptor binding 3/725 22/18722 0.0515219973401616 0.193270881222372 PHLDA2/PTPRF/B2M 3 GO:0016101 diterpenoid metabolic process 7/725 87/18722 0.0516253251479762 0.193270881222372 LRP1/LRP2/AKR1B1/EGFR/RDH10/ADH5/RDH13 7 GO:0044070 regulation of anion transport 7/725 87/18722 0.0516253251479762 0.193270881222372 TCAF1/ITGB1/GABRE/ABCB1/CEBPB/ARL6IP5/GOPC 7 GO:0150104 transport across blood-brain barrier 7/725 87/18722 0.0516253251479762 0.193270881222372 LRP1/LRP2/TFRC/SLC16A12/SLC38A1/ABCB1/SLC7A5 7 GO:0009132 nucleoside diphosphate metabolic process 9/725 124/18722 0.0517111958692645 0.193449484768488 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/DLG1/AK3 9 GO:0006090 pyruvate metabolic process 8/725 106/18722 0.0534467305683199 0.197826539348239 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1/MPC2 8 GO:0008347 glial cell migration 5/725 53/18722 0.0535917076828215 0.197826539348239 LRP1/ADGRG1/LAMB1/GLI3/RTN4 5 GO:0016925 protein sumoylation 5/725 53/18722 0.0535917076828215 0.197826539348239 CBX4/HMG20B/ZNF451/MDM2/RANBP2 5 GO:0045806 negative regulation of endocytosis 5/725 53/18722 0.0535917076828215 0.197826539348239 CAV1/ITGAV/LRPAP1/RAC1/SDCBP 5 GO:0071320 cellular response to cAMP 5/725 53/18722 0.0535917076828215 0.197826539348239 AKAP9/APP/EZR/HSPA5/FDX1 5 GO:0060415 muscle tissue morphogenesis 6/725 70/18722 0.0535955120793055 0.197826539348239 LRP2/TGFBR3/ISL1/RBPJ/LY6E/ENG 6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4/725 37/18722 0.0536765968797846 0.197826539348239 RPS21/RPS16/RPS8/RPS19 4 GO:0001990 regulation of systemic arterial blood pressure by hormone 4/725 37/18722 0.0536765968797846 0.197826539348239 ENPEP/RHOA/ATP6AP2/CYBA 4 GO:0043403 skeletal muscle tissue regeneration 4/725 37/18722 0.0536765968797846 0.197826539348239 DAG1/ANXA1/HOPX/CFLAR 4 GO:0045616 regulation of keratinocyte differentiation 4/725 37/18722 0.0536765968797846 0.197826539348239 ROCK1/NCOA3/SRSF6/NUMA1 4 GO:0048846 axon extension involved in axon guidance 4/725 37/18722 0.0536765968797846 0.197826539348239 NRP2/SEMA6D/SEMA6A/SEMA4C 4 GO:0051294 establishment of spindle orientation 4/725 37/18722 0.0536765968797846 0.197826539348239 ITGB1/GJA1/GPSM2/NUMA1 4 GO:0060416 response to growth hormone 4/725 37/18722 0.0536765968797846 0.197826539348239 CSH1/LEPROTL1/GHR/GDF15 4 GO:1902284 neuron projection extension involved in neuron projection guidance 4/725 37/18722 0.0536765968797846 0.197826539348239 NRP2/SEMA6D/SEMA6A/SEMA4C 4 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 4/725 37/18722 0.0536765968797846 0.197826539348239 MAP3K4/PKIB/DHX36/HNRNPA1 4 GO:0018210 peptidyl-threonine modification 9/725 125/18722 0.0539049981199885 0.197826539348239 GALNT11/APP/PRKDC/CALM1/BMP7/CSNK2B/ROCK1/BCL2/RIPK2 9 GO:0001843 neural tube closure 7/725 88/18722 0.0543036933897579 0.197826539348239 SPINT1/LRP2/COBL/PFN1/BRD2/SETD2/SEMA4C 7 GO:0007260 tyrosine phosphorylation of STAT protein 7/725 88/18722 0.0543036933897579 0.197826539348239 CAV1/ISL1/CSH1/IL6ST/SOCS1/GHR/HES1 7 GO:0050792 regulation of viral process 11/725 164/18722 0.0543716834648216 0.197826539348239 HACD3/DDB1/DDX5/STOM/MPHOSPH8/P4HB/BCL2/LARP1/PKN2/LY6E/PPIA 11 GO:0006814 sodium ion transport 15/725 245/18722 0.054587523581335 0.197826539348239 FXYD3/UTRN/KIF5B/STOM/SLC6A8/SLC38A1/SLC13A4/SLC6A4/SLC9A1/DLG1/MAGED2/SLC20A1/ARF1/GLRX/SGK1 15 GO:0002002 regulation of angiotensin levels in blood 2/725 10/18722 0.0548325681168426 0.197826539348239 ENPEP/ATP6AP2 2 GO:0002003 angiotensin maturation 2/725 10/18722 0.0548325681168426 0.197826539348239 ENPEP/ATP6AP2 2 GO:0003056 regulation of vascular associated smooth muscle contraction 2/725 10/18722 0.0548325681168426 0.197826539348239 ATP2B1/RHOA 2 GO:0003163 sinoatrial node development 2/725 10/18722 0.0548325681168426 0.197826539348239 TBX3/ISL1 2 GO:0007028 cytoplasm organization 2/725 10/18722 0.0548325681168426 0.197826539348239 KIF5B/TFCP2L1 2 GO:0010172 embryonic body morphogenesis 2/725 10/18722 0.0548325681168426 0.197826539348239 DAG1/PHLDB2 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 2/725 10/18722 0.0548325681168426 0.197826539348239 P4HB/ERO1A 2 GO:0021903 rostrocaudal neural tube patterning 2/725 10/18722 0.0548325681168426 0.197826539348239 ATP6AP2/HES1 2 GO:0021932 hindbrain radial glia guided cell migration 2/725 10/18722 0.0548325681168426 0.197826539348239 ITGB1/RERE 2 GO:0031340 positive regulation of vesicle fusion 2/725 10/18722 0.0548325681168426 0.197826539348239 KIF5B/ANXA1 2 GO:0032070 regulation of deoxyribonuclease activity 2/725 10/18722 0.0548325681168426 0.197826539348239 NPM1/HMGB1 2 GO:0033572 transferrin transport 2/725 10/18722 0.0548325681168426 0.197826539348239 TFRC/CLTC 2 GO:0035907 dorsal aorta development 2/725 10/18722 0.0548325681168426 0.197826539348239 RBPJ/ENG 2 GO:0036363 transforming growth factor beta activation 2/725 10/18722 0.0548325681168426 0.197826539348239 ITGAV/LTBP1 2 GO:0045625 regulation of T-helper 1 cell differentiation 2/725 10/18722 0.0548325681168426 0.197826539348239 ANXA1/RIPK2 2 GO:0048703 embryonic viscerocranium morphogenesis 2/725 10/18722 0.0548325681168426 0.197826539348239 RDH10/NIPBL 2 GO:0048755 branching morphogenesis of a nerve 2/725 10/18722 0.0548325681168426 0.197826539348239 RERE/RTN4 2 GO:0051660 establishment of centrosome localization 2/725 10/18722 0.0548325681168426 0.197826539348239 EZR/DLG1 2 GO:0060923 cardiac muscle cell fate commitment 2/725 10/18722 0.0548325681168426 0.197826539348239 TBX3/RBPJ 2 GO:0072124 regulation of glomerular mesangial cell proliferation 2/725 10/18722 0.0548325681168426 0.197826539348239 BMP7/CFLAR 2 GO:0072203 cell proliferation involved in metanephros development 2/725 10/18722 0.0548325681168426 0.197826539348239 BMP7/GPC3 2 GO:0090647 modulation of age-related behavioral decline 2/725 10/18722 0.0548325681168426 0.197826539348239 APP/B2M 2 GO:0097084 vascular associated smooth muscle cell development 2/725 10/18722 0.0548325681168426 0.197826539348239 HES1/ENG 2 GO:1901203 positive regulation of extracellular matrix assembly 2/725 10/18722 0.0548325681168426 0.197826539348239 DAG1/PHLDB2 2 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/725 10/18722 0.0548325681168426 0.197826539348239 PMAIP1/DDIT3 2 GO:1903867 extraembryonic membrane development 2/725 10/18722 0.0548325681168426 0.197826539348239 MAP3K4/BMP7 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/725 10/18722 0.0548325681168426 0.197826539348239 LRP1/LRP2 2 GO:1905383 protein localization to presynapse 2/725 10/18722 0.0548325681168426 0.197826539348239 KIF5B/HSPB1 2 GO:2000121 regulation of removal of superoxide radicals 2/725 10/18722 0.0548325681168426 0.197826539348239 NFE2L2/BMP7 2 GO:2001225 regulation of chloride transport 2/725 10/18722 0.0548325681168426 0.197826539348239 GABRE/ABCB1 2 GO:0140014 mitotic nuclear division 17/725 287/18722 0.0551032949454831 0.198661879145557 RPL24/IGF2/DUSP1/RHOA/LRP5/BMP7/ATRX/HSPA1A/NIPBL/KPNB1/CDC42/STAG1/NEK6/NUMA1/RAB11A/CCSAP/CENPF 17 GO:0051961 negative regulation of nervous system development 10/725 145/18722 0.0555465447542818 0.199975451249613 SEMA6D/SEMA6A/NF1/BMP7/HOOK3/DICER1/HES1/SEMA4C/RTN4/B2M 10 GO:0061351 neural precursor cell proliferation 10/725 145/18722 0.0555465447542818 0.199975451249613 SPINT1/ADGRG1/LRP2/BTG2/GLI3/RHOA/NF1/SLC6A4/HOOK3/RERE 10 GO:0006275 regulation of DNA replication 8/725 107/18722 0.0559035659799693 0.200548602938757 S100A11/JUN/EGFR/ZBTB38/ATRX/CDC42/HRAS/RAC1 8 GO:0008637 apoptotic mitochondrial changes 8/725 107/18722 0.0559035659799693 0.200548602938757 JUN/PMAIP1/HSPD1/BNIP3L/NMT1/BCL2/HSPA1A/CHCHD10 8 GO:0042303 molting cycle 8/725 107/18722 0.0559035659799693 0.200548602938757 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NIPBL/NUMA1 8 GO:0042633 hair cycle 8/725 107/18722 0.0559035659799693 0.200548602938757 LGR5/LGR4/EGFR/LAMA5/RBPJ/BCL2/NIPBL/NUMA1 8 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 8/725 107/18722 0.0559035659799693 0.200548602938757 MIF/APP/HSPD1/ISL1/HSPB1/RIPK2/HMGB1/CYBA 8 GO:0070371 ERK1 and ERK2 cascade 19/725 330/18722 0.0560726030830052 0.20101274754438 FBLN1/LRP1/MIF/APP/ITGAV/SEMA6A/DUSP1/EGFR/DUSP6/EZR/DUSP9/APELA/DLG1/HRAS/CFLAR/RIPK2/HMGB1/ATF3/TIMP3 19 GO:0070372 regulation of ERK1 and ERK2 cascade 18/725 309/18722 0.0564032343244494 0.202055119993381 FBLN1/LRP1/MIF/APP/SEMA6A/DUSP1/EGFR/DUSP6/EZR/DUSP9/APELA/DLG1/HRAS/CFLAR/RIPK2/HMGB1/ATF3/TIMP3 18 GO:0002040 sprouting angiogenesis 12/725 185/18722 0.0564675106279475 0.20214252215612 ITGB1/SEMA6A/PKM/EPHB4/ANXA1/PGF/RHOA/GLUL/APELA/CDC42/HMGB1/PIK3CB 12 GO:0061515 myeloid cell development 6/725 71/18722 0.0567170983100252 0.202892710891685 FBN1/APP/RPS6/WASF2/FAM210B/PIP4K2A 6 GO:0046330 positive regulation of JNK cascade 7/725 89/18722 0.057067286295552 0.203714136783206 APP/GADD45B/CDC42/HRAS/RIPK2/HMGB1/SDCBP 7 GO:0051781 positive regulation of cell division 7/725 89/18722 0.057067286295552 0.203714136783206 IGF2/PGF/RHOA/PKN2/CAT/CDC42/YBX1 7 GO:0060606 tube closure 7/725 89/18722 0.057067286295552 0.203714136783206 SPINT1/LRP2/COBL/PFN1/BRD2/SETD2/SEMA4C 7 GO:0031050 dsRNA processing 5/725 54/18722 0.0572637072321608 0.20384110390437 EGFR/DDX5/DICER1/PUM1/AGO2 5 GO:0070918 production of small RNA involved in gene silencing by RNA 5/725 54/18722 0.0572637072321608 0.20384110390437 EGFR/DDX5/DICER1/PUM1/AGO2 5 GO:0072348 sulfur compound transport 5/725 54/18722 0.0572637072321608 0.20384110390437 SLC26A2/SLC19A3/GJA1/SLC13A4/MFSD12 5 GO:1902743 regulation of lamellipodium organization 5/725 54/18722 0.0572637072321608 0.20384110390437 KANK1/WASF2/CDC42/RAC1/CAPZB 5 GO:0002363 alpha-beta T cell lineage commitment 3/725 23/18722 0.0576035181687607 0.203905191059671 CTSL/RHOA/BCL2 3 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 3/725 23/18722 0.0576035181687607 0.203905191059671 LRP1/PTPN12/CBLB 3 GO:0019430 removal of superoxide radicals 3/725 23/18722 0.0576035181687607 0.203905191059671 SOD3/NFE2L2/BMP7 3 GO:0021871 forebrain regionalization 3/725 23/18722 0.0576035181687607 0.203905191059671 ADGRG1/GLI3/TRA2B 3 GO:0030539 male genitalia development 3/725 23/18722 0.0576035181687607 0.203905191059671 LGR4/DHCR24/TBX3 3 GO:0051131 chaperone-mediated protein complex assembly 3/725 23/18722 0.0576035181687607 0.203905191059671 HSPD1/HSPA1A/HOPX 3 GO:2000737 negative regulation of stem cell differentiation 3/725 23/18722 0.0576035181687607 0.203905191059671 NFE2L2/N4BP2L2/HES1 3 GO:2001169 regulation of ATP biosynthetic process 3/725 23/18722 0.0576035181687607 0.203905191059671 PARP1/TMSB4X/ENO1 3 GO:0002478 antigen processing and presentation of exogenous peptide antigen 4/725 38/18722 0.0582302938021267 0.205100585315286 CTSL/CTSV/LGMN/B2M 4 GO:0010613 positive regulation of cardiac muscle hypertrophy 4/725 38/18722 0.0582302938021267 0.205100585315286 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:0035886 vascular associated smooth muscle cell differentiation 4/725 38/18722 0.0582302938021267 0.205100585315286 PDCD4/HES1/DNMT1/ENG 4 GO:0046633 alpha-beta T cell proliferation 4/725 38/18722 0.0582302938021267 0.205100585315286 CD55/RIPK2/ARG2/CBLB 4 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 4/725 38/18722 0.0582302938021267 0.205100585315286 BNIP3L/NMT1/HSPA1A/CHCHD10 4 GO:2000279 negative regulation of DNA biosynthetic process 4/725 38/18722 0.0582302938021267 0.205100585315286 DUSP1/GJA1/HNRNPA1/CDKN1A 4 GO:1902904 negative regulation of supramolecular fiber organization 11/725 166/18722 0.0583184249598729 0.205100585315286 KANK1/HSPA8/MET/TRIOBP/TMSB4X/PPP1R9A/WASF2/PHLDB2/PFN1/TACSTD2/CAPZB 11 GO:0008217 regulation of blood pressure 12/725 186/18722 0.0583458362644786 0.205100585315286 ATP2B1/ADRB1/GJA1/NR2F2/ENPEP/RHOA/LRP5/GJA5/ATP6AP2/ADH5/SGK1/CYBA 12 GO:0031345 negative regulation of cell projection organization 12/725 186/18722 0.0583458362644786 0.205100585315286 LRP1/KANK1/SEMA6D/SEMA6A/RHOA/MDM2/MYLIP/TACSTD2/SEMA4C/RTN4/CAPZB/B2M 12 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 12/725 186/18722 0.0583458362644786 0.205100585315286 GAPDH/WLS/BRD4/TFRC/GJA1/RHOA/DHX36/SLC20A1/NEK6/TMED4/CFLAR/RIPK2 12 GO:0033138 positive regulation of peptidyl-serine phosphorylation 8/725 108/18722 0.0584311249921389 0.205258054459565 AKAP9/CAV1/MIF/APP/TFRC/EGFR/BCL2/RIPK2 8 GO:0048565 digestive tract development 9/725 127/18722 0.058472265515059 0.20526032818271 LGR4/EGFR/GLI3/IL6ST/COBL/BCL2/NIPBL/CDKN1A/HES1 9 GO:0051090 regulation of DNA-binding transcription factor activity 24/725 440/18722 0.058528258892257 0.205314701954914 ANXA4/CAV1/APP/TFRC/PLPP3/S100A9/TMSB4X/LRP5/NPM1/BMP7/ARID5B/HSPA1A/UFL1/CAT/KDM5A/ERC1/PURA/HES1/CFLAR/DDIT3/RIPK2/SRI/SGK1/PPIA 24 GO:0015711 organic anion transport 20/725 354/18722 0.0596049162913195 0.208946971425103 SLC26A2/ITGB1/LRP2/GJA1/ANXA1/SLC6A8/SLC16A12/SLC38A1/PSAP/SLC7A6/SLC52A3/SLC35B4/SLC52A1/ARL6IP5/SLC38A9/MPC2/MFSD12/SLC2A8/SLC16A3/SLC7A5 20 GO:0099175 regulation of postsynapse organization 7/725 90/18722 0.059916467114626 0.20956194789209 NRP2/HSPA8/PPP1R9A/HOMER1/DHX36/CFL1/ARF4 7 GO:0032729 positive regulation of interferon-gamma production 6/725 72/18722 0.0599457140350229 0.20956194789209 HSPD1/ISL1/PDE4B/HRAS/RIPK2/SLC7A5 6 GO:0042246 tissue regeneration 6/725 72/18722 0.0599457140350229 0.20956194789209 DAG1/ANXA1/PTPN12/HOPX/CDKN1A/CFLAR 6 GO:0051057 positive regulation of small GTPase mediated signal transduction 6/725 72/18722 0.0599457140350229 0.20956194789209 ADGRG1/ITGAV/NET1/HRAS/RAC1/PIK3CB 6 GO:0035303 regulation of dephosphorylation 9/725 128/18722 0.0608464302896883 0.212489253725676 SLC39A10/CALM1/HSP90B1/CSNK2B/ROCK1/BOD1L1/PPP6R2/PPP1R15A/PPIA 9 GO:0072503 cellular divalent inorganic cation homeostasis 26/725 486/18722 0.0608993094472741 0.212489253725676 ATP2B1/TPT1/CAV1/LRP1/APP/ITGAV/SLC39A10/S100A9/GJA1/CALM1/HSP90B1/BCL2/AFG3L2/HERPUD1/CCDC47/ATP13A3/GTF2I/CD55/C1QTNF1/ERO1A/GRINA/DDIT3/HMGB1/SRI/GSTO1/CYBA 26 GO:0043266 regulation of potassium ion transport 8/725 109/18722 0.0610297535944825 0.212489253725676 AKAP9/CAV1/ITGB1/CD63/KIF5B/KCNN4/DLG1/VAMP2 8 GO:0006414 translational elongation 5/725 55/18722 0.0610765126609409 0.212489253725676 EEF1A1/RPLP1/EEF1B2/SECISBP2L/EIF5A 5 GO:0042220 response to cocaine 5/725 55/18722 0.0610765126609409 0.212489253725676 HSPD1/DNMT3A/HSPA5/HOMER1/MDM2 5 GO:0045620 negative regulation of lymphocyte differentiation 5/725 55/18722 0.0610765126609409 0.212489253725676 ANXA1/GLI3/SOCS1/INHA/HMGB1 5 GO:0061614 pri-miRNA transcription by RNA polymerase II 5/725 55/18722 0.0610765126609409 0.212489253725676 FOS/JUN/DDX5/TEAD1/NR3C1 5 GO:0044839 cell cycle G2/M phase transition 10/725 148/18722 0.0620698515209508 0.215649127731117 BRD4/APP/CALM1/ABCB1/PBX1/NPM1/CDKN1A/RAB11A/BACH1/CENPF 10 GO:1903900 regulation of viral life cycle 10/725 148/18722 0.0620698515209508 0.215649127731117 HACD3/DDB1/DDX5/MPHOSPH8/P4HB/BCL2/LARP1/PKN2/LY6E/PPIA 10 GO:0016482 cytosolic transport 11/725 168/18722 0.0624500710692041 0.216821513869723 KIF5B/EZR/HOOK3/SPAG9/CLTC/SYT7/ERC1/TMEM87A/PIP4K2A/RHOBTB3/ARL8B 11 GO:0018212 peptidyl-tyrosine modification 21/725 378/18722 0.0628956926106588 0.21748193063708 CAV1/IGF2/MIF/APP/EPHB4/EGFR/EFEMP1/MET/NEURL1/ISL1/CSH1/IL6ST/SOCS1/TPST2/GHR/IQGAP1/BAZ1B/HES1/RIPK2/FLT1/CBLB 21 GO:0014742 positive regulation of muscle hypertrophy 4/725 39/18722 0.0629835222282961 0.21748193063708 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:0016233 telomere capping 4/725 39/18722 0.0629835222282961 0.21748193063708 MAP3K4/PRKDC/PKIB/RAD50 4 GO:0031507 heterochromatin assembly 4/725 39/18722 0.0629835222282961 0.21748193063708 MPHOSPH8/DNMT3A/DNMT1/MBD3 4 GO:0034314 Arp2/3 complex-mediated actin nucleation 4/725 39/18722 0.0629835222282961 0.21748193063708 IQGAP2/WASF2/ARPC3/ARF1 4 GO:0071548 response to dexamethasone 4/725 39/18722 0.0629835222282961 0.21748193063708 EGFR/NR3C1/SERPINF1/CFLAR 4 GO:2000249 regulation of actin cytoskeleton reorganization 4/725 39/18722 0.0629835222282961 0.21748193063708 IQGAP2/CDC42/HRAS/PHPT1 4 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 4/725 39/18722 0.0629835222282961 0.21748193063708 ANXA1/SOCS1/CD55/RIPK2 4 GO:0006022 aminoglycan metabolic process 9/725 129/18722 0.0632813558407732 0.218180411109177 ITIH5/GNS/B3GNT2/CLTC/HEXA/BGN/B3GAT3/CHST12/GLCE 9 GO:0007498 mesoderm development 9/725 129/18722 0.0632813558407732 0.218180411109177 WLS/ITGB1/ITGB4/GJA1/TBX3/BMP7/APELA/TXNRD1/SETD2 9 GO:0061387 regulation of extent of cell growth 8/725 110/18722 0.063699746664876 0.218180411109177 LRP1/SEMA6D/SEMA6A/MACF1/GOLGA4/SEMA4C/RAB11A/RTN4 8 GO:0006582 melanin metabolic process 3/725 24/18722 0.0640070500574578 0.218180411109177 OPN3/BCL2/MFSD12 3 GO:0007035 vacuolar acidification 3/725 24/18722 0.0640070500574578 0.218180411109177 ATP6V0E1/GRN/ATP6AP2 3 GO:0010288 response to lead ion 3/725 24/18722 0.0640070500574578 0.218180411109177 APP/DNMT3A/CAT 3 GO:0016486 peptide hormone processing 3/725 24/18722 0.0640070500574578 0.218180411109177 ENPEP/CTSL/ATP6AP2 3 GO:0030859 polarized epithelial cell differentiation 3/725 24/18722 0.0640070500574578 0.218180411109177 DLG5/RHOA/CDC42 3 GO:0031639 plasminogen activation 3/725 24/18722 0.0640070500574578 0.218180411109177 DHCR24/ENO1/SERPINE1 3 GO:0033032 regulation of myeloid cell apoptotic process 3/725 24/18722 0.0640070500574578 0.218180411109177 ANXA1/BCL2/PIK3CB 3 GO:0051043 regulation of membrane protein ectodomain proteolysis 3/725 24/18722 0.0640070500574578 0.218180411109177 ROCK1/TIMP3/TIMP2 3 GO:0090343 positive regulation of cell aging 3/725 24/18722 0.0640070500574578 0.218180411109177 YPEL3/ARG2/B2M 3 GO:1903077 negative regulation of protein localization to plasma membrane 3/725 24/18722 0.0640070500574578 0.218180411109177 CLTC/GOPC/TMBIM1 3 GO:0002090 regulation of receptor internalization 5/725 56/18722 0.0650297645951683 0.218180411109177 CD63/LRPAP1/APELA/ARF1/SDCBP 5 GO:0010518 positive regulation of phospholipase activity 5/725 56/18722 0.0650297645951683 0.218180411109177 EGFR/GNAQ/HRAS/ARF4/FLT1 5 GO:0022029 telencephalon cell migration 5/725 56/18722 0.0650297645951683 0.218180411109177 ADGRG1/LAMB1/GLI3/RHOA/RTN4 5 GO:0046622 positive regulation of organ growth 5/725 56/18722 0.0650297645951683 0.218180411109177 IGF2/BASP1/TGFBR3/RBPJ/SERP1 5 GO:0048008 platelet-derived growth factor receptor signaling pathway 5/725 56/18722 0.0650297645951683 0.218180411109177 LRP1/TXNIP/ARID5B/PTPN12/CBLB 5 GO:0051058 negative regulation of small GTPase mediated signal transduction 5/725 56/18722 0.0650297645951683 0.218180411109177 ITGB1/KANK1/MET/RASA1/TIMP2 5 GO:0090175 regulation of establishment of planar polarity 5/725 56/18722 0.0650297645951683 0.218180411109177 ZNRF3/RHOA/GPC3/CDC42/RAC1 5 GO:1904645 response to amyloid-beta 5/725 56/18722 0.0650297645951683 0.218180411109177 LRP1/APP/GJA1/PARP1/LGMN 5 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 2/725 11/18722 0.0653379096594457 0.218180411109177 CD46/CD55 2 GO:0003174 mitral valve development 2/725 11/18722 0.0653379096594457 0.218180411109177 SOX4/GJA5 2 GO:0003263 cardioblast proliferation 2/725 11/18722 0.0653379096594457 0.218180411109177 ISL1/HES1 2 GO:0003264 regulation of cardioblast proliferation 2/725 11/18722 0.0653379096594457 0.218180411109177 ISL1/HES1 2 GO:0007042 lysosomal lumen acidification 2/725 11/18722 0.0653379096594457 0.218180411109177 GRN/ATP6AP2 2 GO:0014854 response to inactivity 2/725 11/18722 0.0653379096594457 0.218180411109177 DAG1/CAT 2 GO:0030432 peristalsis 2/725 11/18722 0.0653379096594457 0.218180411109177 TBX3/DLG1 2 GO:0032276 regulation of gonadotropin secretion 2/725 11/18722 0.0653379096594457 0.218180411109177 GJA1/INHA 2 GO:0033690 positive regulation of osteoblast proliferation 2/725 11/18722 0.0653379096594457 0.218180411109177 ITGAV/LRP5 2 GO:0033860 regulation of NAD(P)H oxidase activity 2/725 11/18722 0.0653379096594457 0.218180411109177 RFK/CYBA 2 GO:0034163 regulation of toll-like receptor 9 signaling pathway 2/725 11/18722 0.0653379096594457 0.218180411109177 RTN4/HMGB1 2 GO:0043589 skin morphogenesis 2/725 11/18722 0.0653379096594457 0.218180411109177 ITGB4/ITGA6 2 GO:0048096 chromatin-mediated maintenance of transcription 2/725 11/18722 0.0653379096594457 0.218180411109177 SERTAD1/SERTAD2 2 GO:0048680 positive regulation of axon regeneration 2/725 11/18722 0.0653379096594457 0.218180411109177 LRP1/GRN 2 GO:0048715 negative regulation of oligodendrocyte differentiation 2/725 11/18722 0.0653379096594457 0.218180411109177 NF1/HES1 2 GO:0060379 cardiac muscle cell myoblast differentiation 2/725 11/18722 0.0653379096594457 0.218180411109177 ISL1/RBPJ 2 GO:0061314 Notch signaling involved in heart development 2/725 11/18722 0.0653379096594457 0.218180411109177 GALNT11/RBPJ 2 GO:0072110 glomerular mesangial cell proliferation 2/725 11/18722 0.0653379096594457 0.218180411109177 BMP7/CFLAR 2 GO:0072173 metanephric tubule morphogenesis 2/725 11/18722 0.0653379096594457 0.218180411109177 LGR4/HES1 2 GO:0072205 metanephric collecting duct development 2/725 11/18722 0.0653379096594457 0.218180411109177 DLG5/AKR1B1 2 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 2/725 11/18722 0.0653379096594457 0.218180411109177 MPHOSPH8/DNMT1 2 GO:0098935 dendritic transport 2/725 11/18722 0.0653379096594457 0.218180411109177 KIF5B/PURA 2 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/725 11/18722 0.0653379096594457 0.218180411109177 ARRDC3/PDE4B 2 GO:1900426 positive regulation of defense response to bacterium 2/725 11/18722 0.0653379096594457 0.218180411109177 GRN/CYBA 2 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/725 11/18722 0.0653379096594457 0.218180411109177 NMT1/CHCHD10 2 GO:1902915 negative regulation of protein polyubiquitination 2/725 11/18722 0.0653379096594457 0.218180411109177 TRIM44/PPIA 2 GO:1903897 regulation of PERK-mediated unfolded protein response 2/725 11/18722 0.0653379096594457 0.218180411109177 HSPA5/PPP1R15A 2 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 2/725 11/18722 0.0653379096594457 0.218180411109177 LRP1/HMGB1 2 GO:2000786 positive regulation of autophagosome assembly 2/725 11/18722 0.0653379096594457 0.218180411109177 RALB/PIP4K2A 2 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 9/725 130/18722 0.0657773019139202 0.21950305688062 LMAN1/PDCD6/GOPC/TRIP11/TMED4/KDELR2/ARF4/RAB1A/ARF1 9 GO:0034249 negative regulation of cellular amide metabolic process 16/725 273/18722 0.0661618047685214 0.220495850342955 GAPDH/ORMDL1/BTG2/RPL13A/DHX36/IGF2BP3/ROCK1/PUM1/LARP1/TNRC6B/CPEB4/PURA/AGO2/RTN4/PAIP2/YBX1 16 GO:0046942 carboxylic acid transport 16/725 273/18722 0.0661618047685214 0.220495850342955 SLC26A2/ITGB1/LRP2/GJA1/ANXA1/SLC6A8/SLC16A12/SLC38A1/PSAP/SLC7A6/ARL6IP5/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5 16 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 6/725 74/18722 0.0667245229241939 0.222079190218476 DDX5/ISL1/PARP1/RHOA/UFL1/UBA5 6 GO:1903201 regulation of oxidative stress-induced cell death 6/725 74/18722 0.0667245229241939 0.222079190218476 MET/PARP1/NFE2L2/HSPB1/P4HB/PPIA 6 GO:0050807 regulation of synapse organization 13/725 211/18722 0.067322680208726 0.223923009171937 NRP2/DLG5/APP/DAG1/HSPA8/NEURL1/RHOA/PPP1R9A/HOMER1/DHX36/CFL1/CDC42/ARF4 13 GO:0010863 positive regulation of phospholipase C activity 4/725 40/18722 0.0679341340005003 0.224923661168214 EGFR/GNAQ/HRAS/FLT1 4 GO:0030501 positive regulation of bone mineralization 4/725 40/18722 0.0679341340005003 0.224923661168214 ATP2B1/FBN2/BMP7/TFAP2A 4 GO:0035329 hippo signaling 4/725 40/18722 0.0679341340005003 0.224923661168214 DLG5/LATS2/TEAD1/AMOT 4 GO:0044275 cellular carbohydrate catabolic process 4/725 40/18722 0.0679341340005003 0.224923661168214 TPI1/AGL/GAA/HMGB1 4 GO:0071276 cellular response to cadmium ion 4/725 40/18722 0.0679341340005003 0.224923661168214 FOS/JUN/EGFR/UBE2D3 4 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 4/725 40/18722 0.0679341340005003 0.224923661168214 C4orf3/CALM1/SRI/GSTO1 4 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 4/725 40/18722 0.0679341340005003 0.224923661168214 BNIP3L/NMT1/HSPA1A/CHCHD10 4 GO:0006874 cellular calcium ion homeostasis 24/725 448/18722 0.0687341848518485 0.227424009800274 ATP2B1/TPT1/CAV1/LRP1/APP/ITGAV/GJA1/CALM1/HSP90B1/BCL2/AFG3L2/HERPUD1/CCDC47/ATP13A3/GTF2I/CD55/C1QTNF1/ERO1A/GRINA/DDIT3/HMGB1/SRI/GSTO1/CYBA 24 GO:1903131 mononuclear cell differentiation 23/725 426/18722 0.068812241035847 0.227533757215074 ITGB1/CD46/JUN/PRKDC/RPS6/DHRS2/ANXA1/RBPJ/PNP/SOX4/GLI3/PBX1/CTSL/RHOA/SOCS1/TPD52/BCL2/RPL22/CEBPB/INHA/RIPK2/HMGB1/B2M 23 GO:0060349 bone morphogenesis 7/725 93/18722 0.0689800233362364 0.227791360450412 GLG1/GLI3/LRP5/GHR/TRIP11/TFAP2A/SERPINH1 7 GO:0097306 cellular response to alcohol 7/725 93/18722 0.0689800233362364 0.227791360450412 ATP2B1/DAG1/CDH1/DNMT3A/LARP1/MDM2/FDX1 7 GO:1904064 positive regulation of cation transmembrane transport 10/725 151/18722 0.0690692378925087 0.227890397405932 AKAP9/KIF5B/KCNN4/CALM1/TMSB4X/SLC9A1/SRI/ARF1/GLRX/GSTO1 10 GO:0033619 membrane protein proteolysis 5/725 57/18722 0.0691228949636829 0.227890397405932 DAG1/ROCK1/AFG3L2/TIMP3/TIMP2 5 GO:0048193 Golgi vesicle transport 17/725 296/18722 0.0691448868041672 0.227890397405932 CUX1/KRT18/PLPP3/LMAN1/MACF1/GOLGA4/PDCD6/GOPC/TRIP11/EXOC1/UVRAG/TMED4/VAMP2/KDELR2/ARF4/RAB1A/ARF1 17 GO:0006790 sulfur compound metabolic process 19/725 339/18722 0.0692172140273223 0.227980544447366 SLC26A2/CLIC3/ACSS1/SLC19A3/NFE2L2/IDH1/GNS/TPST2/MTR/B3GNT2/GPX4/BGN/ARL6IP5/GHR/CHST12/GLCE/MPC2/CLIC1/GSTO1 19 GO:0015980 energy derivation by oxidation of organic compounds 18/725 318/18722 0.0701029706671732 0.230691619402713 IGF2/UGP2/AGL/GAA/PHLDA2/IDH1/PHKB/IL6ST/RHOA/OPN3/PLEC/COX6A1/CAT/UQCRH/HMGB1/CHCHD2/SDHA/CHCHD10 18 GO:0006024 glycosaminoglycan biosynthetic process 6/725 75/18722 0.0702746577718923 0.230691619402713 B3GNT2/CLTC/HEXA/B3GAT3/CHST12/GLCE 6 GO:0048662 negative regulation of smooth muscle cell proliferation 6/725 75/18722 0.0702746577718923 0.230691619402713 IGFBP3/SF1/PDCD4/GNA12/RHOA/CDKN1A 6 GO:0003094 glomerular filtration 3/725 25/18722 0.0707229782110506 0.230691619402713 GJA1/GJA5/CYBA 3 GO:0010447 response to acidic pH 3/725 25/18722 0.0707229782110506 0.230691619402713 LGMN/SLC9A1/SERPINF1 3 GO:0015012 heparan sulfate proteoglycan biosynthetic process 3/725 25/18722 0.0707229782110506 0.230691619402713 EXTL2/B3GAT3/GLCE 3 GO:0060706 cell differentiation involved in embryonic placenta development 3/725 25/18722 0.0707229782110506 0.230691619402713 KRT19/KRT8/NR2F2 3 GO:0061436 establishment of skin barrier 3/725 25/18722 0.0707229782110506 0.230691619402713 MET/CLDN4/PLEC 3 GO:0071450 cellular response to oxygen radical 3/725 25/18722 0.0707229782110506 0.230691619402713 SOD3/NFE2L2/BMP7 3 GO:0071451 cellular response to superoxide 3/725 25/18722 0.0707229782110506 0.230691619402713 SOD3/NFE2L2/BMP7 3 GO:0072012 glomerulus vasculature development 3/725 25/18722 0.0707229782110506 0.230691619402713 BMP7/HES1/CFLAR 3 GO:0140448 signaling receptor ligand precursor processing 3/725 25/18722 0.0707229782110506 0.230691619402713 ENPEP/CTSL/ATP6AP2 3 GO:1903055 positive regulation of extracellular matrix organization 3/725 25/18722 0.0707229782110506 0.230691619402713 DAG1/PHLDB2/CFLAR 3 GO:1903792 negative regulation of anion transport 3/725 25/18722 0.0707229782110506 0.230691619402713 GABRE/ARL6IP5/GOPC 3 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 3/725 25/18722 0.0707229782110506 0.230691619402713 GNA12/NFE2L2/RHOA 3 GO:1901136 carbohydrate derivative catabolic process 11/725 172/18722 0.0712758794471578 0.232345616024208 UPP1/PNP/CTSL/PDE4B/GNS/HEXA/NAGK/HINT1/MANBA/TDG/PGM2 11 GO:0051924 regulation of calcium ion transport 15/725 255/18722 0.0717060759208338 0.233597749898911 ATP2B1/C4orf3/CAV1/GJA1/CALM1/RHOA/PDE4B/HOMER1/BCL2/CAMK2G/SLC9A1/SARAF/SRI/GSTO1/CYBA 15 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 7/725 94/18722 0.0721736602928441 0.23436789495479 EGFR/NR2F2/CCNL1/LATS2/SERTAD1/CDKN1A/CDKN1C 7 GO:0030316 osteoclast differentiation 7/725 94/18722 0.0721736602928441 0.23436789495479 FBN1/FOS/TFRC/FSTL3/GPC3/ESRRA/CEBPB 7 GO:0032091 negative regulation of protein binding 7/725 94/18722 0.0721736602928441 0.23436789495479 CAV1/LRPAP1/ROCK1/PTPRF/RALB/CDKN1A/B2M 7 GO:0048704 embryonic skeletal system morphogenesis 7/725 94/18722 0.0721736602928441 0.23436789495479 GLI3/BMP7/RDH10/DLG1/NIPBL/TFAP2A/SETD2 7 GO:0051702 biological process involved in interaction with symbiont 7/725 94/18722 0.0721736602928441 0.23436789495479 GAPDH/JUN/HSPD1/HSPA8/DDB1/STOM/CFL1 7 GO:0001953 negative regulation of cell-matrix adhesion 4/725 41/18722 0.0730795949032082 0.236401063538202 LRP1/PHLDB2/RASA1/SERPINE1 4 GO:0010907 positive regulation of glucose metabolic process 4/725 41/18722 0.0730795949032082 0.236401063538202 IGF2/PMAIP1/DDB1/HMGB1 4 GO:0032735 positive regulation of interleukin-12 production 4/725 41/18722 0.0730795949032082 0.236401063538202 HSPD1/ISL1/RIPK2/HMGB1 4 GO:0050856 regulation of T cell receptor signaling pathway 4/725 41/18722 0.0730795949032082 0.236401063538202 KCNN4/EZR/PHPT1/CBLB 4 GO:0071634 regulation of transforming growth factor beta production 4/725 41/18722 0.0730795949032082 0.236401063538202 CD46/ITGAV/LTBP1/ATP6AP2 4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 4/725 41/18722 0.0730795949032082 0.236401063538202 TRIOBP/P4HB/CDC42/RAC1 4 GO:0001954 positive regulation of cell-matrix adhesion 5/725 58/18722 0.0733551324724807 0.236838959556054 UTRN/DAG1/ROCK1/IQGAP1/RAC1 5 GO:0009161 ribonucleoside monophosphate metabolic process 5/725 58/18722 0.0733551324724807 0.236838959556054 UPP1/PNP/DLG1/AK3/RFK 5 GO:0045604 regulation of epidermal cell differentiation 5/725 58/18722 0.0733551324724807 0.236838959556054 ROCK1/NCOA3/SRSF6/HES1/NUMA1 5 GO:0010469 regulation of signaling receptor activity 11/725 173/18722 0.0736006743506928 0.237480469945042 AKAP9/ITGB1/APP/NEURL1/PHLDA2/LRPAP1/HOMER1/NCOA3/LY6E/SERPINE1/CBLB 11 GO:0045685 regulation of glial cell differentiation 6/725 76/18722 0.0739317081715857 0.238245282086311 SPINT1/DAG1/IL6ST/NF1/DICER1/HES1 6 GO:0140115 export across plasma membrane 6/725 76/18722 0.0739317081715857 0.238245282086311 ATP2B1/GJA1/CALM1/ABCB1/SLC9A1/DLG1 6 GO:0008593 regulation of Notch signaling pathway 7/725 95/18722 0.0754535563693318 0.240391545399469 GALNT11/CD46/AAK1/NEURL1/IL6ST/BMP7/HES1 7 GO:1901379 regulation of potassium ion transmembrane transport 7/725 95/18722 0.0754535563693318 0.240391545399469 AKAP9/CAV1/ITGB1/CD63/KCNN4/DLG1/VAMP2 7 GO:0030217 T cell differentiation 15/725 257/18722 0.0755124759575305 0.240391545399469 CD46/PRKDC/RPS6/ANXA1/PNP/SOX4/GLI3/CTSL/RHOA/SOCS1/BCL2/RPL22/RIPK2/HMGB1/B2M 15 GO:0001659 temperature homeostasis 11/725 174/18722 0.0759731171821275 0.240391545399469 CAV1/LGR4/ADRB1/GJA1/RBPJ/ARRDC3/SCD/DYNC1H1/CEBPB/DDIT3/ESRRG 11 GO:0045619 regulation of lymphocyte differentiation 11/725 174/18722 0.0759731171821275 0.240391545399469 CD46/PRKDC/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/INHA/RIPK2/HMGB1 11 GO:0009100 glycoprotein metabolic process 21/725 387/18722 0.0761542896731503 0.240391545399469 GALNT11/EXTL2/C1GALT1/TET2/CTSL/ITM2B/RPN2/GANAB/B3GNT2/BCL2/MAN1A2/BGN/FUT8/B3GAT3/TRIP11/CHST12/GLCE/MANBA/AGO2/SERP1/RAB1A 21 GO:0002424 T cell mediated immune response to tumor cell 2/725 12/18722 0.0764472620209004 0.240391545399469 HSPD1/HMGB1 2 GO:0002664 regulation of T cell tolerance induction 2/725 12/18722 0.0764472620209004 0.240391545399469 PHLPP1/CBLB 2 GO:0010623 programmed cell death involved in cell development 2/725 12/18722 0.0764472620209004 0.240391545399469 PRKDC/BCL2 2 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 2/725 12/18722 0.0764472620209004 0.240391545399469 LRP1/PTPN12 2 GO:0021559 trigeminal nerve development 2/725 12/18722 0.0764472620209004 0.240391545399469 ISL1/TFAP2A 2 GO:0021978 telencephalon regionalization 2/725 12/18722 0.0764472620209004 0.240391545399469 ADGRG1/TRA2B 2 GO:0030238 male sex determination 2/725 12/18722 0.0764472620209004 0.240391545399469 MAP3K4/SF1 2 GO:0031453 positive regulation of heterochromatin assembly 2/725 12/18722 0.0764472620209004 0.240391545399469 MPHOSPH8/DNMT1 2 GO:0031953 negative regulation of protein autophosphorylation 2/725 12/18722 0.0764472620209004 0.240391545399469 CAV1/ENG 2 GO:0033629 negative regulation of cell adhesion mediated by integrin 2/725 12/18722 0.0764472620209004 0.240391545399469 JAM3/SERPINE1 2 GO:0034086 maintenance of sister chromatid cohesion 2/725 12/18722 0.0764472620209004 0.240391545399469 ATRX/NIPBL 2 GO:0034088 maintenance of mitotic sister chromatid cohesion 2/725 12/18722 0.0764472620209004 0.240391545399469 ATRX/NIPBL 2 GO:0035739 CD4-positive, alpha-beta T cell proliferation 2/725 12/18722 0.0764472620209004 0.240391545399469 CD55/ARG2 2 GO:0045605 negative regulation of epidermal cell differentiation 2/725 12/18722 0.0764472620209004 0.240391545399469 SRSF6/HES1 2 GO:0045683 negative regulation of epidermis development 2/725 12/18722 0.0764472620209004 0.240391545399469 SRSF6/HES1 2 GO:0045916 negative regulation of complement activation 2/725 12/18722 0.0764472620209004 0.240391545399469 CD46/CD55 2 GO:0048548 regulation of pinocytosis 2/725 12/18722 0.0764472620209004 0.240391545399469 CAV1/CDC42 2 GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/725 12/18722 0.0764472620209004 0.240391545399469 BMP7/HES1 2 GO:0061308 cardiac neural crest cell development involved in heart development 2/725 12/18722 0.0764472620209004 0.240391545399469 BMP7/HES1 2 GO:0070493 thrombin-activated receptor signaling pathway 2/725 12/18722 0.0764472620209004 0.240391545399469 IQGAP2/MET 2 GO:0070572 positive regulation of neuron projection regeneration 2/725 12/18722 0.0764472620209004 0.240391545399469 LRP1/GRN 2 GO:0071287 cellular response to manganese ion 2/725 12/18722 0.0764472620209004 0.240391545399469 APP/HSPA5 2 GO:0071472 cellular response to salt stress 2/725 12/18722 0.0764472620209004 0.240391545399469 AKR1B1/EFHD1 2 GO:0071872 cellular response to epinephrine stimulus 2/725 12/18722 0.0764472620209004 0.240391545399469 PDE4B/SLC9A1 2 GO:0072520 seminiferous tubule development 2/725 12/18722 0.0764472620209004 0.240391545399469 ADGRG1/ATRX 2 GO:0090385 phagosome-lysosome fusion 2/725 12/18722 0.0764472620209004 0.240391545399469 SYT7/ARL8B 2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 2/725 12/18722 0.0764472620209004 0.240391545399469 JUN/HSPA1A 2 GO:0120263 positive regulation of heterochromatin organization 2/725 12/18722 0.0764472620209004 0.240391545399469 MPHOSPH8/DNMT1 2 GO:1903332 regulation of protein folding 2/725 12/18722 0.0764472620209004 0.240391545399469 GRN/HSPA5 2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/725 12/18722 0.0764472620209004 0.240391545399469 EGFR/DDX5 2 GO:1990034 calcium ion export across plasma membrane 2/725 12/18722 0.0764472620209004 0.240391545399469 ATP2B1/CALM1 2 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 2/725 12/18722 0.0764472620209004 0.240391545399469 CD55/ARG2 2 GO:2000628 regulation of miRNA metabolic process 2/725 12/18722 0.0764472620209004 0.240391545399469 KCNQ1OT1/HRAS 2 GO:0043010 camera-type eye development 18/725 322/18722 0.076857117053812 0.241530518503269 ATP2B1/FBN1/FBN2/TENM3/RPL24/EFEMP1/GLI3/LRP5/NF1/BMP7/RDH10/DLG1/SERPINF1/C12orf57/TFAP2A/KDM5B/RDH13/FLT1 18 GO:0021885 forebrain cell migration 5/725 59/18722 0.0777255084505533 0.241638790071389 ADGRG1/LAMB1/GLI3/RHOA/RTN4 5 GO:0051568 histone H3-K4 methylation 5/725 59/18722 0.0777255084505533 0.241638790071389 KMT2C/TET2/ASH1L/RTF1/DNMT1 5 GO:0071806 protein transmembrane transport 5/725 59/18722 0.0777255084505533 0.241638790071389 HSPD1/HSPA5/SEC62/SEC61B/SEC61G 5 GO:0032515 negative regulation of phosphoprotein phosphatase activity 3/725 26/18722 0.0777410076415351 0.241638790071389 ROCK1/BOD1L1/PPP1R15A 3 GO:0033522 histone H2A ubiquitination 3/725 26/18722 0.0777410076415351 0.241638790071389 DDB1/SKP1/UBE2A 3 GO:0046697 decidualization 3/725 26/18722 0.0777410076415351 0.241638790071389 GJA1/CTSV/ASH1L 3 GO:0048668 collateral sprouting 3/725 26/18722 0.0777410076415351 0.241638790071389 LRP1/APP/COBL 3 GO:0048843 negative regulation of axon extension involved in axon guidance 3/725 26/18722 0.0777410076415351 0.241638790071389 SEMA6D/SEMA6A/SEMA4C 3 GO:0060037 pharyngeal system development 3/725 26/18722 0.0777410076415351 0.241638790071389 ISL1/BMP7/HES1 3 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 3/725 26/18722 0.0777410076415351 0.241638790071389 CALM1/SRI/GSTO1 3 GO:0060352 cell adhesion molecule production 3/725 26/18722 0.0777410076415351 0.241638790071389 CAV1/COLEC12/PPIA 3 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 3/725 26/18722 0.0777410076415351 0.241638790071389 ADRB1/ARRDC3/PDE4B 3 GO:0097205 renal filtration 3/725 26/18722 0.0777410076415351 0.241638790071389 GJA1/GJA5/CYBA 3 GO:1904353 regulation of telomere capping 3/725 26/18722 0.0777410076415351 0.241638790071389 MAP3K4/PKIB/RAD50 3 GO:1904376 negative regulation of protein localization to cell periphery 3/725 26/18722 0.0777410076415351 0.241638790071389 CLTC/GOPC/TMBIM1 3 GO:1905063 regulation of vascular associated smooth muscle cell differentiation 3/725 26/18722 0.0777410076415351 0.241638790071389 PDCD4/DNMT1/ENG 3 GO:0031334 positive regulation of protein-containing complex assembly 14/725 237/18722 0.0777545719838553 0.241638790071389 IQGAP2/AKAP9/TFRC/CLIP1/MET/RHOA/WASF2/HSPA1A/DLG1/ARPC3/PFN1/NUMA1/RAC1/ARF1 14 GO:0006913 nucleocytoplasmic transport 17/725 301/18722 0.0779038896319173 0.241638790071389 CDH1/TXNIP/PTTG1IP/GLI3/NPM1/PPP1R10/PTPN14/PABPN1/HNRNPA1/MDM2/TNPO1/RANBP2/KPNB1/UPF2/CDKN1A/SETD2/CBLB 17 GO:0051169 nuclear transport 17/725 301/18722 0.0779038896319173 0.241638790071389 CDH1/TXNIP/PTTG1IP/GLI3/NPM1/PPP1R10/PTPN14/PABPN1/HNRNPA1/MDM2/TNPO1/RANBP2/KPNB1/UPF2/CDKN1A/SETD2/CBLB 17 GO:0034968 histone lysine methylation 8/725 115/18722 0.0781268931469222 0.241638790071389 BRD4/KMT2C/TET2/ATRX/ASH1L/RTF1/DNMT1/SETD2 8 GO:0043279 response to alkaloid 8/725 115/18722 0.0781268931469222 0.241638790071389 HSPD1/FOSB/DNMT3A/HSPA5/HOMER1/SRSF9/GHR/MDM2 8 GO:0046916 cellular transition metal ion homeostasis 8/725 115/18722 0.0781268931469222 0.241638790071389 APP/TFRC/SLC39A10/S100A9/FTH1/SRI/ARF1/ATP6V1G1 8 GO:0000413 protein peptidyl-prolyl isomerization 4/725 42/18722 0.0784170072336624 0.241638790071389 NKTR/PPIG/RANBP2/PPIA 4 GO:0010591 regulation of lamellipodium assembly 4/725 42/18722 0.0784170072336624 0.241638790071389 WASF2/CDC42/RAC1/CAPZB 4 GO:0016601 Rac protein signal transduction 4/725 42/18722 0.0784170072336624 0.241638790071389 HACD3/WASF2/RAC1/PIK3CB 4 GO:0019692 deoxyribose phosphate metabolic process 4/725 42/18722 0.0784170072336624 0.241638790071389 UPP1/PNP/TDG/PGM2 4 GO:0033574 response to testosterone 4/725 42/18722 0.0784170072336624 0.241638790071389 DUSP1/NASP/CSNK2B/CFLAR 4 GO:0045773 positive regulation of axon extension 4/725 42/18722 0.0784170072336624 0.241638790071389 LRP1/MACF1/GOLGA4/RAB11A 4 GO:0051452 intracellular pH reduction 4/725 42/18722 0.0784170072336624 0.241638790071389 ATP6V0E1/GRN/BCL2/ATP6AP2 4 GO:1900274 regulation of phospholipase C activity 4/725 42/18722 0.0784170072336624 0.241638790071389 EGFR/GNAQ/HRAS/FLT1 4 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 4/725 42/18722 0.0784170072336624 0.241638790071389 FOS/JUN/TEAD1/NR3C1 4 GO:2001222 regulation of neuron migration 4/725 42/18722 0.0784170072336624 0.241638790071389 ADGRG1/SEMA6A/NIPBL/ZNF609 4 GO:0021700 developmental maturation 16/725 280/18722 0.0787839033506294 0.242621874899356 CD63/APP/DAG1/AKR1B1/NEURL1/RBPJ/RHOA/TFCP2L1/BCL2/RERE/ATP6AP2/PFN1/FAM210B/CDKN1A/HES1/DDIT3 16 GO:0006606 protein import into nucleus 10/725 155/18722 0.0791518527603202 0.243542251139805 CDH1/TXNIP/PTTG1IP/GLI3/PPP1R10/TNPO1/RANBP2/KPNB1/CDKN1A/CBLB 10 GO:0002687 positive regulation of leukocyte migration 9/725 135/18722 0.079178857738883 0.243542251139805 APP/PGF/RHOA/JAM3/LGMN/HMGB1/CD99/SERPINE1/RAC1 9 GO:0022408 negative regulation of cell-cell adhesion 12/725 196/18722 0.0794340267177594 0.244030958443832 DLG5/CDH1/ANXA1/GLI3/SOCS1/CEBPB/DLG1/C1QTNF1/HMGB1/ZNF703/ARG2/CBLB 12 GO:0071674 mononuclear cell migration 12/725 196/18722 0.0794340267177594 0.244030958443832 APP/DUSP1/ANXA1/RPS19/RHOA/LGMN/PLEC/CDC42/HMGB1/CD99/SERPINE1/FLT1 12 GO:0043534 blood vessel endothelial cell migration 11/725 176/18722 0.0808613970965747 0.248265549292875 ITGB1/EPHB4/ANXA1/TMSB4X/NFE2L2/RHOA/NF1/HSPB1/CSNK2B/AMOT/HMGB1 11 GO:0051656 establishment of organelle localization 21/725 390/18722 0.0809637639964571 0.248288096092842 ARMCX3/ITGB1/SYNE2/KIF5B/GJA1/PDCD6/EZR/NPM1/DYNC1H1/HOOK3/CFL1/DLG1/TRIP11/GPSM2/KPNB1/CDC42/NUMA1/RAB11A/RAB1A/CENPF/ARF1 21 GO:0009150 purine ribonucleotide metabolic process 20/725 368/18722 0.0809667040523708 0.248288096092842 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3 20 GO:0018107 peptidyl-threonine phosphorylation 8/725 116/18722 0.0812283776886986 0.248789514503935 APP/PRKDC/CALM1/BMP7/CSNK2B/ROCK1/BCL2/RIPK2 8 GO:0030518 intracellular steroid hormone receptor signaling pathway 8/725 116/18722 0.0812283776886986 0.248789514503935 DDX5/ISL1/PARP1/RHOA/UFL1/NR3C1/DDX17/UBA5 8 GO:0051091 positive regulation of DNA-binding transcription factor activity 15/725 260/18722 0.0814662697025223 0.249185708345584 CAV1/APP/TFRC/PLPP3/S100A9/LRP5/NPM1/ARID5B/HSPA1A/CAT/ERC1/CFLAR/DDIT3/RIPK2/PPIA 15 GO:0008306 associative learning 6/725 78/18722 0.0815651382933495 0.249185708345584 ITGB1/FOS/APP/BTG2/NF1/LGMN 6 GO:0019319 hexose biosynthetic process 6/725 78/18722 0.0815651382933495 0.249185708345584 TPI1/AKR1B1/DDB1/SLC35B4/RANBP2/ATF3 6 GO:0034637 cellular carbohydrate biosynthetic process 6/725 78/18722 0.0815651382933495 0.249185708345584 IGF2/UGP2/AGL/AKR1B1/ISYNA1/B3GNT2 6 GO:0015849 organic acid transport 17/725 303/18722 0.0816035265049652 0.249185708345584 SLC26A2/PLIN2/ITGB1/LRP2/GJA1/ANXA1/SLC38A1/SLC27A2/CROT/ABCB1/SLC7A6/ARL6IP5/SLC38A9/MPC2/MFSD12/SLC16A3/SLC7A5 17 GO:0042445 hormone metabolic process 13/725 218/18722 0.0820942093725224 0.250321210398833 CYP11A1/AKR1B1/DHRS2/ENPEP/CTSL/RDH10/GHR/ATP6AP2/HSD3B1/HSD17B1/RDH13/CYP19A1/FDX1 13 GO:0050803 regulation of synapse structure or activity 13/725 218/18722 0.0820942093725224 0.250321210398833 NRP2/DLG5/APP/DAG1/HSPA8/NEURL1/RHOA/PPP1R9A/HOMER1/DHX36/CFL1/CDC42/ARF4 13 GO:0006081 cellular aldehyde metabolic process 5/725 60/18722 0.0822328630260127 0.250321210398833 TPI1/IDH1/RDH10/ADH5/RDH13 5 GO:1903670 regulation of sprouting angiogenesis 5/725 60/18722 0.0822328630260127 0.250321210398833 SEMA6A/PKM/GLUL/HMGB1/PIK3CB 5 GO:0006721 terpenoid metabolic process 7/725 97/18722 0.0822716781464698 0.250321210398833 LRP1/LRP2/AKR1B1/EGFR/RDH10/ADH5/RDH13 7 GO:0120162 positive regulation of cold-induced thermogenesis 7/725 97/18722 0.0822716781464698 0.250321210398833 CAV1/ADRB1/GJA1/SCD/DYNC1H1/CEBPB/ESRRG 7 GO:0006509 membrane protein ectodomain proteolysis 4/725 43/18722 0.0839431323884832 0.254034470493864 DAG1/ROCK1/TIMP3/TIMP2 4 GO:0009268 response to pH 4/725 43/18722 0.0839431323884832 0.254034470493864 GJA1/LGMN/SLC9A1/SERPINF1 4 GO:0021983 pituitary gland development 4/725 43/18722 0.0839431323884832 0.254034470493864 CDH1/ISL1/RBPJ/HES1 4 GO:0030517 negative regulation of axon extension 4/725 43/18722 0.0839431323884832 0.254034470493864 SEMA6D/SEMA6A/SEMA4C/RTN4 4 GO:0042088 T-helper 1 type immune response 4/725 43/18722 0.0839431323884832 0.254034470493864 ANXA1/HRAS/RIPK2/HMGB1 4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4/725 43/18722 0.0839431323884832 0.254034470493864 MIF/RPL26/BCL2/CDKN1A 4 GO:0071604 transforming growth factor beta production 4/725 43/18722 0.0839431323884832 0.254034470493864 CD46/ITGAV/LTBP1/ATP6AP2 4 GO:1903793 positive regulation of anion transport 4/725 43/18722 0.0839431323884832 0.254034470493864 TCAF1/ITGB1/ABCB1/CEBPB 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/725 43/18722 0.0839431323884832 0.254034470493864 PDCD4/GNA12/RHOA/CDKN1A 4 GO:0051250 negative regulation of lymphocyte activation 10/725 157/18722 0.0845168198946128 0.255100473221659 DLG5/ANXA1/GLI3/SOCS1/CEBPB/DLG1/INHA/HMGB1/ARG2/CBLB 10 GO:0000086 G2/M transition of mitotic cell cycle 9/725 137/18722 0.0849715832224235 0.255100473221659 BRD4/APP/CALM1/ABCB1/PBX1/CDKN1A/RAB11A/BACH1/CENPF 9 GO:0030879 mammary gland development 9/725 137/18722 0.0849715832224235 0.255100473221659 CAV1/TBX3/NEURL1/GLI3/LRP5/CEBPB/KDM5B/RTN4/ZNF703 9 GO:0003171 atrioventricular valve development 3/725 27/18722 0.0850502662743348 0.255100473221659 SOX4/GJA5/MDM2 3 GO:0008053 mitochondrial fusion 3/725 27/18722 0.0850502662743348 0.255100473221659 TFRC/AFG3L2/HUWE1 3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3/725 27/18722 0.0850502662743348 0.255100473221659 CALM1/SLC9A1/GSTO1 3 GO:0018126 protein hydroxylation 3/725 27/18722 0.0850502662743348 0.255100473221659 P4HB/ASPH/ERO1A 3 GO:0031954 positive regulation of protein autophosphorylation 3/725 27/18722 0.0850502662743348 0.255100473221659 CALM1/RAD50/IQGAP1 3 GO:0033561 regulation of water loss via skin 3/725 27/18722 0.0850502662743348 0.255100473221659 MET/CLDN4/PLEC 3 GO:0034453 microtubule anchoring 3/725 27/18722 0.0850502662743348 0.255100473221659 DAG1/HOOK3/CEP350 3 GO:0061437 renal system vasculature development 3/725 27/18722 0.0850502662743348 0.255100473221659 BMP7/HES1/CFLAR 3 GO:0061440 kidney vasculature development 3/725 27/18722 0.0850502662743348 0.255100473221659 BMP7/HES1/CFLAR 3 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 3/725 27/18722 0.0850502662743348 0.255100473221659 CD63/SEMA6A/PIK3CB 3 GO:1902914 regulation of protein polyubiquitination 3/725 27/18722 0.0850502662743348 0.255100473221659 TRIM44/SASH1/PPIA 3 GO:1903421 regulation of synaptic vesicle recycling 3/725 27/18722 0.0850502662743348 0.255100473221659 CALM1/ROCK1/VAMP2 3 GO:0006023 aminoglycan biosynthetic process 6/725 79/18722 0.0855405230998131 0.256267678246426 B3GNT2/CLTC/HEXA/B3GAT3/CHST12/GLCE 6 GO:0060420 regulation of heart growth 6/725 79/18722 0.0855405230998131 0.256267678246426 BASP1/TGFBR3/GJA1/DUSP6/RBPJ/DUSP9 6 GO:0003333 amino acid transmembrane transport 7/725 98/18722 0.0858094938772039 0.256649402678129 ITGB1/SLC38A1/SLC7A6/ARL6IP5/SLC38A9/MFSD12/SLC7A5 7 GO:1904029 regulation of cyclin-dependent protein kinase activity 7/725 98/18722 0.0858094938772039 0.256649402678129 EGFR/NR2F2/CCNL1/LATS2/SERTAD1/CDKN1A/CDKN1C 7 GO:0006109 regulation of carbohydrate metabolic process 11/725 178/18722 0.08594140347236 0.256649402678129 IGF2/APP/PMAIP1/DDB1/PHLDA2/CLTC/SLC35B4/RANBP2/C1QTNF1/NCOA2/HMGB1 11 GO:0035725 sodium ion transmembrane transport 11/725 178/18722 0.08594140347236 0.256649402678129 FXYD3/UTRN/KIF5B/STOM/SLC6A8/SLC6A4/SLC9A1/DLG1/SLC20A1/ARF1/GLRX 11 GO:0055074 calcium ion homeostasis 24/725 460/18722 0.0862515593175192 0.256649402678129 ATP2B1/TPT1/CAV1/LRP1/APP/ITGAV/GJA1/CALM1/HSP90B1/BCL2/AFG3L2/HERPUD1/CCDC47/ATP13A3/GTF2I/CD55/C1QTNF1/ERO1A/GRINA/DDIT3/HMGB1/SRI/GSTO1/CYBA 24 GO:0002064 epithelial cell development 13/725 220/18722 0.0866644853514531 0.256649402678129 ADAMTSL4/AKR1B1/MET/TRIOBP/EZR/IL6ST/ATRX/ROCK1/TFCP2L1/PLEC/IQGAP1/FLNB/CDKN1A 13 GO:0019748 secondary metabolic process 5/725 61/18722 0.0868758515928995 0.256649402678129 AKR1B1/NFE2L2/OPN3/BCL2/MFSD12 5 GO:0043030 regulation of macrophage activation 5/725 61/18722 0.0868758515928995 0.256649402678129 MIF/JUND/HSPD1/CTSC/GRN 5 GO:0043954 cellular component maintenance 5/725 61/18722 0.0868758515928995 0.256649402678129 HOMER1/DLG1/MTSS1/ERC1/CHCHD10 5 GO:0060998 regulation of dendritic spine development 5/725 61/18722 0.0868758515928995 0.256649402678129 DLG5/NEURL1/PPP1R9A/DHX36/ARF1 5 GO:1904356 regulation of telomere maintenance via telomere lengthening 5/725 61/18722 0.0868758515928995 0.256649402678129 MAP3K4/PARP1/PKIB/DHX36/HNRNPA1 5 GO:0043488 regulation of mRNA stability 10/725 158/18722 0.087280399406464 0.256649402678129 FUS/BTG2/NPM1/DHX36/ROCK1/PUM1/LARP1/TNRC6B/AGO2/YBX1 10 GO:0055076 transition metal ion homeostasis 9/725 138/18722 0.0879606151337409 0.256649402678129 APP/TFRC/SLC39A10/S100A9/FTH1/SRI/ARF1/B2M/ATP6V1G1 9 GO:0001778 plasma membrane repair 2/725 13/18722 0.0880982364687204 0.256649402678129 SYT7/ARL8B 2 GO:0002551 mast cell chemotaxis 2/725 13/18722 0.0880982364687204 0.256649402678129 PGF/RAC1 2 GO:0003222 ventricular trabecula myocardium morphogenesis 2/725 13/18722 0.0880982364687204 0.256649402678129 RBPJ/ENG 2 GO:0003334 keratinocyte development 2/725 13/18722 0.0880982364687204 0.256649402678129 PLEC/FLNB 2 GO:0006000 fructose metabolic process 2/725 13/18722 0.0880982364687204 0.256649402678129 ALDOA/AKR1B1 2 GO:0010635 regulation of mitochondrial fusion 2/725 13/18722 0.0880982364687204 0.256649402678129 TFRC/HUWE1 2 GO:0010755 regulation of plasminogen activation 2/725 13/18722 0.0880982364687204 0.256649402678129 ENO1/SERPINE1 2 GO:0010958 regulation of amino acid import across plasma membrane 2/725 13/18722 0.0880982364687204 0.256649402678129 ITGB1/ARL6IP5 2 GO:0010960 magnesium ion homeostasis 2/725 13/18722 0.0880982364687204 0.256649402678129 EGFR/CNNM2 2 GO:0016246 RNA interference 2/725 13/18722 0.0880982364687204 0.256649402678129 DICER1/AGO2 2 GO:0021554 optic nerve development 2/725 13/18722 0.0880982364687204 0.256649402678129 RPL24/GLI3 2 GO:0021819 layer formation in cerebral cortex 2/725 13/18722 0.0880982364687204 0.256649402678129 ADGRG1/GLI3 2 GO:0034135 regulation of toll-like receptor 2 signaling pathway 2/725 13/18722 0.0880982364687204 0.256649402678129 HMGB1/CYBA 2 GO:0036462 TRAIL-activated apoptotic signaling pathway 2/725 13/18722 0.0880982364687204 0.256649402678129 ATF3/TIMP3 2 GO:0042538 hyperosmotic salinity response 2/725 13/18722 0.0880982364687204 0.256649402678129 AKR1B1/EFHD1 2 GO:0042769 DNA damage response, detection of DNA damage 2/725 13/18722 0.0880982364687204 0.256649402678129 PARP1/SOX4 2 GO:0046642 negative regulation of alpha-beta T cell proliferation 2/725 13/18722 0.0880982364687204 0.256649402678129 ARG2/CBLB 2 GO:0048012 hepatocyte growth factor receptor signaling pathway 2/725 13/18722 0.0880982364687204 0.256649402678129 MET/RAC1 2 GO:0048711 positive regulation of astrocyte differentiation 2/725 13/18722 0.0880982364687204 0.256649402678129 IL6ST/HES1 2 GO:0060347 heart trabecula formation 2/725 13/18722 0.0880982364687204 0.256649402678129 TGFBR3/ADAMTS1 2 GO:0070254 mucus secretion 2/725 13/18722 0.0880982364687204 0.256649402678129 EGFR/CYBA 2 GO:0070486 leukocyte aggregation 2/725 13/18722 0.0880982364687204 0.256649402678129 S100A9/BMP7 2 GO:0098840 protein transport along microtubule 2/725 13/18722 0.0880982364687204 0.256649402678129 KIF5B/HSPB1 2 GO:0099118 microtubule-based protein transport 2/725 13/18722 0.0880982364687204 0.256649402678129 KIF5B/HSPB1 2 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/725 13/18722 0.0880982364687204 0.256649402678129 ARRDC3/PDE4B 2 GO:0110096 cellular response to aldehyde 2/725 13/18722 0.0880982364687204 0.256649402678129 AKR1B1/ADH5 2 GO:1900121 negative regulation of receptor binding 2/725 13/18722 0.0880982364687204 0.256649402678129 PTPRF/B2M 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/725 13/18722 0.0880982364687204 0.256649402678129 APP/PPP1R9A 2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 2/725 13/18722 0.0880982364687204 0.256649402678129 TMSB4X/DDIT3 2 GO:1903789 regulation of amino acid transmembrane transport 2/725 13/18722 0.0880982364687204 0.256649402678129 ITGB1/ARL6IP5 2 GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation 2/725 13/18722 0.0880982364687204 0.256649402678129 PDCD4/DNMT1 2 GO:1905244 regulation of modification of synaptic structure 2/725 13/18722 0.0880982364687204 0.256649402678129 RHOA/CDC42 2 GO:1905269 positive regulation of chromatin organization 2/725 13/18722 0.0880982364687204 0.256649402678129 MPHOSPH8/DNMT1 2 GO:1990403 embryonic brain development 2/725 13/18722 0.0880982364687204 0.256649402678129 RPL10/TRA2B 2 GO:2001198 regulation of dendritic cell differentiation 2/725 13/18722 0.0880982364687204 0.256649402678129 CEBPB/HMGB1 2 GO:0010950 positive regulation of endopeptidase activity 11/725 179/18722 0.0885534226182313 0.257679276263958 PMAIP1/S100A9/HSPD1/PDCD6/RHOA/LGMN/ARL6IP5/ASPH/CFLAR/RIPK2/HMGB1 11 GO:1901991 negative regulation of mitotic cell cycle phase transition 11/725 179/18722 0.0885534226182313 0.257679276263958 PRKDC/DUSP1/CTDSPL/SOX4/RPL26/BRD7/BCL2/DLG1/MDM2/CDKN1A/CENPF 11 GO:0006165 nucleoside diphosphate phosphorylation 7/725 99/18722 0.0894327503289674 0.259542102399957 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1 7 GO:0010717 regulation of epithelial to mesenchymal transition 7/725 99/18722 0.0894327503289674 0.259542102399957 DAG1/ISL1/BMP7/PHLDB2/ZNF703/ENG/SDCBP 7 GO:0030838 positive regulation of actin filament polymerization 7/725 99/18722 0.0894327503289674 0.259542102399957 IQGAP2/RHOA/WASF2/DLG1/ARPC3/PFN1/ARF1 7 GO:0007422 peripheral nervous system development 6/725 80/18722 0.0896208379954941 0.259542102399957 ITGB4/DAG1/ISL1/NF1/DICER1/PLEC 6 GO:0048145 regulation of fibroblast proliferation 6/725 80/18722 0.0896208379954941 0.259542102399957 MIF/FTH1/PRKDC/NF1/CDKN1A/S100A6 6 GO:0032881 regulation of polysaccharide metabolic process 4/725 44/18722 0.08965441335615 0.259542102399957 IGF2/PHLDA2/CLTC/HMGB1 4 GO:0048066 developmental pigmentation 4/725 44/18722 0.08965441335615 0.259542102399957 CD63/GLI3/BCL2/ATP6AP2 4 GO:0050999 regulation of nitric-oxide synthase activity 4/725 44/18722 0.08965441335615 0.259542102399957 CAV1/EGFR/CALM1/PIK3CB 4 GO:1903214 regulation of protein targeting to mitochondrion 4/725 44/18722 0.08965441335615 0.259542102399957 LMAN1/BNIP3L/HUWE1/UBE2D3 4 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 15/725 264/18722 0.0898642429836263 0.260001054614156 CAV1/IGF2/MIF/APP/EGFR/NEURL1/ISL1/CSH1/IL6ST/SOCS1/GHR/IQGAP1/HES1/RIPK2/CBLB 15 GO:0032200 telomere organization 10/725 159/18722 0.0900980368673327 0.260528778596982 MAP3K4/PRKDC/PARP1/ATRX/PKIB/DHX36/RAD50/PPP1R10/HNRNPA1/NOP10 10 GO:0030098 lymphocyte differentiation 20/725 374/18722 0.091507926905782 0.264271223725458 ITGB1/CD46/PRKDC/RPS6/ANXA1/RBPJ/PNP/SOX4/GLI3/PBX1/CTSL/RHOA/SOCS1/TPD52/BCL2/RPL22/INHA/RIPK2/HMGB1/B2M 20 GO:0032623 interleukin-2 production 5/725 62/18722 0.0916529515307466 0.264271223725458 ANXA1/PNP/EZR/PDE4B/RIPK2 5 GO:0032663 regulation of interleukin-2 production 5/725 62/18722 0.0916529515307466 0.264271223725458 ANXA1/PNP/EZR/PDE4B/RIPK2 5 GO:0032731 positive regulation of interleukin-1 beta production 5/725 62/18722 0.0916529515307466 0.264271223725458 APP/ISL1/HSPB1/RIPK2/HMGB1 5 GO:0032757 positive regulation of interleukin-8 production 5/725 62/18722 0.0916529515307466 0.264271223725458 HSPA1A/DDIT3/HMGB1/RAB1A/SERPINE1 5 GO:0000303 response to superoxide 3/725 28/18722 0.0926393997239147 0.266056157054121 SOD3/NFE2L2/BMP7 3 GO:0001945 lymph vessel development 3/725 28/18722 0.0926393997239147 0.266056157054121 SVEP1/NR2F2/PTPN14 3 GO:0002507 tolerance induction 3/725 28/18722 0.0926393997239147 0.266056157054121 PHLPP1/HMGB1/CBLB 3 GO:0051894 positive regulation of focal adhesion assembly 3/725 28/18722 0.0926393997239147 0.266056157054121 ROCK1/IQGAP1/RAC1 3 GO:0060325 face morphogenesis 3/725 28/18722 0.0926393997239147 0.266056157054121 ANKRD11/ARID5B/NIPBL 3 GO:0080111 DNA demethylation 3/725 28/18722 0.0926393997239147 0.266056157054121 TET2/TDG/USP9X 3 GO:0090344 negative regulation of cell aging 3/725 28/18722 0.0926393997239147 0.266056157054121 MIF/PRKDC/YBX1 3 GO:0018108 peptidyl-tyrosine phosphorylation 20/725 375/18722 0.0933473917731729 0.267937672082794 CAV1/IGF2/MIF/APP/EPHB4/EGFR/EFEMP1/MET/NEURL1/ISL1/CSH1/IL6ST/SOCS1/GHR/IQGAP1/BAZ1B/HES1/RIPK2/FLT1/CBLB 20 GO:0001523 retinoid metabolic process 6/725 81/18722 0.0938053094113102 0.268491876570261 LRP1/LRP2/AKR1B1/RDH10/ADH5/RDH13 6 GO:0044773 mitotic DNA damage checkpoint signaling 6/725 81/18722 0.0938053094113102 0.268491876570261 PRKDC/SOX4/RPL26/PPP1R10/MDM2/CDKN1A 6 GO:0048144 fibroblast proliferation 6/725 81/18722 0.0938053094113102 0.268491876570261 MIF/FTH1/PRKDC/NF1/CDKN1A/S100A6 6 GO:0051817 modulation of process of other organism involved in symbiotic interaction 6/725 81/18722 0.0938053094113102 0.268491876570261 SERPINB9/DAG1/JUN/HSPA8/STOM/CFL1 6 GO:2001021 negative regulation of response to DNA damage stimulus 6/725 81/18722 0.0938053094113102 0.268491876570261 TPT1/MIF/PTTG1IP/PPP1R10/BCL2/MDM2 6 GO:0009913 epidermal cell differentiation 12/725 202/18722 0.0941391569492069 0.26929536488461 ANXA1/RBPJ/TRIOBP/TXNIP/OPN3/ROCK1/NCOA3/PLEC/FLNB/SRSF6/HES1/NUMA1 12 GO:0048593 camera-type eye morphogenesis 8/725 120/18722 0.0943527227196772 0.269602001953801 TENM3/GLI3/LRP5/NF1/BMP7/C12orf57/TFAP2A/RDH13 8 GO:0072655 establishment of protein localization to mitochondrion 8/725 120/18722 0.0943527227196772 0.269602001953801 HSPD1/LMAN1/CALM1/BNIP3L/NMT1/HUWE1/UBE2D3/DDIT3 8 GO:0017148 negative regulation of translation 14/725 245/18722 0.095415389131589 0.27224717699967 GAPDH/BTG2/RPL13A/DHX36/IGF2BP3/ROCK1/PUM1/LARP1/TNRC6B/CPEB4/PURA/AGO2/PAIP2/YBX1 14 GO:0003009 skeletal muscle contraction 4/725 45/18722 0.0955469970176393 0.27224717699967 GAA/HOMER1/C12orf57/GSTO1 4 GO:0035307 positive regulation of protein dephosphorylation 4/725 45/18722 0.0955469970176393 0.27224717699967 SLC39A10/CALM1/PPP1R15A/PPIA 4 GO:0048538 thymus development 4/725 45/18722 0.0955469970176393 0.27224717699967 PRKDC/PBX1/BCL2/HES1 4 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 4/725 45/18722 0.0955469970176393 0.27224717699967 BNIP3L/NMT1/HSPA1A/CHCHD10 4 GO:0032233 positive regulation of actin filament bundle assembly 5/725 63/18722 0.0965624691406706 0.274677416427643 RHOA/PFN1/MTSS1/CDC42/RAC1 5 GO:0050854 regulation of antigen receptor-mediated signaling pathway 5/725 63/18722 0.0965624691406706 0.274677416427643 SLC39A10/KCNN4/EZR/PHPT1/CBLB 5 GO:2000756 regulation of peptidyl-lysine acetylation 5/725 63/18722 0.0965624691406706 0.274677416427643 ISL1/SOX4/ZNF451/BRD7/EID1 5 GO:0046939 nucleotide phosphorylation 7/725 101/18722 0.0969339644656648 0.275579509745628 GAPDH/LDHA/ALDOA/TPI1/APP/PKM/ENO1 7 GO:1903038 negative regulation of leukocyte cell-cell adhesion 9/725 141/18722 0.0972973862094622 0.275906121914404 DLG5/ANXA1/GLI3/SOCS1/CEBPB/DLG1/HMGB1/ARG2/CBLB 9 GO:0006816 calcium ion transport 22/725 422/18722 0.0977384889681333 0.275906121914404 ATP2B1/TPT1/C4orf3/CAV1/ITGAV/GJA1/KCNN4/CALM1/TMEM37/RHOA/PDE4B/HOMER1/BCL2/AFG3L2/CAMK2G/SLC9A1/ERO1A/SARAF/DDIT3/SRI/GSTO1/CYBA 22 GO:0071216 cellular response to biotic stimulus 14/725 246/18722 0.0977843338473685 0.275906121914404 PDCD4/TXNIP/RHOA/PDE4B/HSPA5/CEBPB/PABPN1/CCDC47/CD55/SASH1/DDIT3/RIPK2/HMGB1/SERPINE1 14 GO:0002224 toll-like receptor signaling pathway 8/725 121/18722 0.0978124426136502 0.275906121914404 CAV1/LGR4/HSPD1/COLEC12/RTN4/RIPK2/HMGB1/CYBA 8 GO:0043500 muscle adaptation 8/725 121/18722 0.0978124426136502 0.275906121914404 DAG1/PARP1/IL6ST/ROCK1/CAMK2G/SLC9A1/CFLAR/CYBA 8 GO:0048706 embryonic skeletal system development 8/725 121/18722 0.0978124426136502 0.275906121914404 GLI3/PBX1/BMP7/RDH10/DLG1/NIPBL/TFAP2A/SETD2 8 GO:1904019 epithelial cell apoptotic process 8/725 121/18722 0.0978124426136502 0.275906121914404 KRT8/KRT18/PDCD4/NFE2L2/DNMT3A/SRSF6/CFLAR/SERPINE1 8 GO:0009205 purine ribonucleoside triphosphate metabolic process 6/725 82/18722 0.0980930578618498 0.275906121914404 ALDOA/PARP1/TMSB4X/RHOA/ENO1/AK3 6 GO:0016575 histone deacetylation 6/725 82/18722 0.0980930578618498 0.275906121914404 TBL1X/NIPBL/KDM5A/HOPX/RCOR1/MORF4L2 6 GO:0046364 monosaccharide biosynthetic process 6/725 82/18722 0.0980930578618498 0.275906121914404 TPI1/AKR1B1/DDB1/SLC35B4/RANBP2/ATF3 6 GO:0010498 proteasomal protein catabolic process 25/725 490/18722 0.0983763318438698 0.275906121914404 CAV1/PMAIP1/DDB1/PSMD1/GNA12/NFE2L2/HSP90B1/SKP1/HSPA5/TBL1X/UBXN4/HERPUD1/HSPA1A/UFL1/MDM2/CCDC47/HUWE1/DDA1/DNAJB14/EIF3H/UBE2D3/SEC61B/DDIT3/UBE2A/SDCBP 25 GO:0002091 negative regulation of receptor internalization 2/725 14/18722 0.100232358831578 0.275906121914404 LRPAP1/SDCBP 2 GO:0002517 T cell tolerance induction 2/725 14/18722 0.100232358831578 0.275906121914404 PHLPP1/CBLB 2 GO:0002829 negative regulation of type 2 immune response 2/725 14/18722 0.100232358831578 0.275906121914404 ANXA1/ARG2 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/725 14/18722 0.100232358831578 0.275906121914404 TRIP11/SERPINH1 2 GO:0009158 ribonucleoside monophosphate catabolic process 2/725 14/18722 0.100232358831578 0.275906121914404 UPP1/PNP 2 GO:0009159 deoxyribonucleoside monophosphate catabolic process 2/725 14/18722 0.100232358831578 0.275906121914404 UPP1/PNP 2 GO:0031054 pre-miRNA processing 2/725 14/18722 0.100232358831578 0.275906121914404 DICER1/AGO2 2 GO:0034111 negative regulation of homotypic cell-cell adhesion 2/725 14/18722 0.100232358831578 0.275906121914404 C1QTNF1/ZNF703 2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/725 14/18722 0.100232358831578 0.275906121914404 LRP1/PTPN12 2 GO:0036295 cellular response to increased oxygen levels 2/725 14/18722 0.100232358831578 0.275906121914404 CAV1/ATP6V1G1 2 GO:0038166 angiotensin-activated signaling pathway 2/725 14/18722 0.100232358831578 0.275906121914404 CAV1/ROCK1 2 GO:0042415 norepinephrine metabolic process 2/725 14/18722 0.100232358831578 0.275906121914404 AKR1B1/LY6E 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/725 14/18722 0.100232358831578 0.275906121914404 SOCS1/BCL2 2 GO:0043455 regulation of secondary metabolic process 2/725 14/18722 0.100232358831578 0.275906121914404 OPN3/MFSD12 2 GO:0043558 regulation of translational initiation in response to stress 2/725 14/18722 0.100232358831578 0.275906121914404 NPM1/PPP1R15A 2 GO:0044764 multi-organism cellular process 2/725 14/18722 0.100232358831578 0.275906121914404 CAV1/CTSL 2 GO:0045472 response to ether 2/725 14/18722 0.100232358831578 0.275906121914404 LARP1/MDM2 2 GO:0047484 regulation of response to osmotic stress 2/725 14/18722 0.100232358831578 0.275906121914404 EFHD1/ABCB1 2 GO:0048021 regulation of melanin biosynthetic process 2/725 14/18722 0.100232358831578 0.275906121914404 OPN3/MFSD12 2 GO:0060576 intestinal epithelial cell development 2/725 14/18722 0.100232358831578 0.275906121914404 IL6ST/CDKN1A 2 GO:0061709 reticulophagy 2/725 14/18722 0.100232358831578 0.275906121914404 UFL1/UBA5 2 GO:0070141 response to UV-A 2/725 14/18722 0.100232358831578 0.275906121914404 EGFR/OPN3 2 GO:0072531 pyrimidine-containing compound transmembrane transport 2/725 14/18722 0.100232358831578 0.275906121914404 SLC19A3/SLC25A36 2 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 2/725 14/18722 0.100232358831578 0.275906121914404 CAV1/PDE4B 2 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 2/725 14/18722 0.100232358831578 0.275906121914404 MPHOSPH8/DNMT1 2 GO:0097531 mast cell migration 2/725 14/18722 0.100232358831578 0.275906121914404 PGF/RAC1 2 GO:1900037 regulation of cellular response to hypoxia 2/725 14/18722 0.100232358831578 0.275906121914404 ENO1/CHCHD2 2 GO:1900376 regulation of secondary metabolite biosynthetic process 2/725 14/18722 0.100232358831578 0.275906121914404 OPN3/MFSD12 2 GO:1901077 regulation of relaxation of muscle 2/725 14/18722 0.100232358831578 0.275906121914404 PDE4B/SRI 2 GO:1901722 regulation of cell proliferation involved in kidney development 2/725 14/18722 0.100232358831578 0.275906121914404 BMP7/CFLAR 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/725 14/18722 0.100232358831578 0.275906121914404 MIF/BCL2 2 GO:1903894 regulation of IRE1-mediated unfolded protein response 2/725 14/18722 0.100232358831578 0.275906121914404 HSPA5/UFL1 2 GO:2001171 positive regulation of ATP biosynthetic process 2/725 14/18722 0.100232358831578 0.275906121914404 TMSB4X/ENO1 2 GO:2001256 regulation of store-operated calcium entry 2/725 14/18722 0.100232358831578 0.275906121914404 HOMER1/SARAF 2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/725 29/18722 0.100496658280679 0.275906121914404 BTG2/TNRC6B/AGO2 3 GO:0000305 response to oxygen radical 3/725 29/18722 0.100496658280679 0.275906121914404 SOD3/NFE2L2/BMP7 3 GO:0001773 myeloid dendritic cell activation 3/725 29/18722 0.100496658280679 0.275906121914404 DHRS2/RBPJ/HMGB1 3 GO:0003209 cardiac atrium morphogenesis 3/725 29/18722 0.100496658280679 0.275906121914404 ISL1/SOX4/ENG 3 GO:0010592 positive regulation of lamellipodium assembly 3/725 29/18722 0.100496658280679 0.275906121914404 WASF2/CDC42/RAC1 3 GO:0010955 negative regulation of protein processing 3/725 29/18722 0.100496658280679 0.275906121914404 GLG1/MDM2/SERPINE1 3 GO:0021522 spinal cord motor neuron differentiation 3/725 29/18722 0.100496658280679 0.275906121914404 ISL1/SOX4/GLI3 3 GO:0021591 ventricular system development 3/725 29/18722 0.100496658280679 0.275906121914404 SEMA6D/C12orf57/CENPF 3 GO:0021602 cranial nerve morphogenesis 3/725 29/18722 0.100496658280679 0.275906121914404 NRP2/GLI3/TFAP2A 3 GO:0030970 retrograde protein transport, ER to cytosol 3/725 29/18722 0.100496658280679 0.275906121914404 HSP90B1/HERPUD1/SEC61B 3 GO:0032366 intracellular sterol transport 3/725 29/18722 0.100496658280679 0.275906121914404 SYT7/PIP4K2A/ARL8B 3 GO:0032367 intracellular cholesterol transport 3/725 29/18722 0.100496658280679 0.275906121914404 SYT7/PIP4K2A/ARL8B 3 GO:0048679 regulation of axon regeneration 3/725 29/18722 0.100496658280679 0.275906121914404 LRP1/GRN/PTPRF 3 GO:0060441 epithelial tube branching involved in lung morphogenesis 3/725 29/18722 0.100496658280679 0.275906121914404 DLG5/DAG1/RDH10 3 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3/725 29/18722 0.100496658280679 0.275906121914404 TPT1/MIF/BCL2 3 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 3/725 29/18722 0.100496658280679 0.275906121914404 CD63/SEMA6A/PIK3CB 3 GO:1903318 negative regulation of protein maturation 3/725 29/18722 0.100496658280679 0.275906121914404 GLG1/MDM2/SERPINE1 3 GO:1903513 endoplasmic reticulum to cytosol transport 3/725 29/18722 0.100496658280679 0.275906121914404 HSP90B1/HERPUD1/SEC61B 3 GO:0007009 plasma membrane organization 9/725 142/18722 0.100532374664807 0.275906121914404 CAV1/SPESP1/S100A9/PLEC/SYT7/MTSS1/EPB41L3/SERP1/ARL8B 9 GO:0035710 CD4-positive, alpha-beta T cell activation 7/725 102/18722 0.100810934779979 0.276221961297143 ANXA1/CTSL/SOCS1/CD55/RIPK2/HMGB1/ARG2 7 GO:1902106 negative regulation of leukocyte differentiation 7/725 102/18722 0.100810934779979 0.276221961297143 FBN1/ANXA1/FSTL3/GLI3/SOCS1/INHA/HMGB1 7 GO:1902749 regulation of cell cycle G2/M phase transition 7/725 102/18722 0.100810934779979 0.276221961297143 BRD4/APP/PBX1/NPM1/CDKN1A/RAB11A/CENPF 7 GO:0002688 regulation of leukocyte chemotaxis 8/725 122/18722 0.101343053258353 0.276932976892891 MIF/DUSP1/PGF/JAM3/LGMN/HMGB1/SERPINE1/RAC1 8 GO:0030837 negative regulation of actin filament polymerization 5/725 64/18722 0.101602546763483 0.276932976892891 KANK1/TRIOBP/TMSB4X/PFN1/CAPZB 5 GO:0030888 regulation of B cell proliferation 5/725 64/18722 0.101602546763483 0.276932976892891 MIF/TFRC/SLC39A10/BCL2/CDKN1A 5 GO:0045670 regulation of osteoclast differentiation 5/725 64/18722 0.101602546763483 0.276932976892891 FBN1/FOS/FSTL3/ESRRA/CEBPB 5 GO:0046579 positive regulation of Ras protein signal transduction 5/725 64/18722 0.101602546763483 0.276932976892891 ADGRG1/NET1/HRAS/RAC1/PIK3CB 5 GO:1903409 reactive oxygen species biosynthetic process 5/725 64/18722 0.101602546763483 0.276932976892891 HSPD1/RHOA/CFLAR/ARG2/CYBA 5 GO:0001974 blood vessel remodeling 4/725 46/18722 0.101616756169023 0.276932976892891 RBPJ/BGN/MDM2/TMBIM1 4 GO:0045851 pH reduction 4/725 46/18722 0.101616756169023 0.276932976892891 ATP6V0E1/GRN/BCL2/ATP6AP2 4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 4/725 46/18722 0.101616756169023 0.276932976892891 EGFR/ANXA1/ADAMTS1/MDM2 4 GO:1900271 regulation of long-term synaptic potentiation 4/725 46/18722 0.101616756169023 0.276932976892891 APP/PPP1R9A/LGMN/PAIP2 4 GO:0061025 membrane fusion 10/725 163/18722 0.101907950984623 0.277577325922113 SPESP1/KIF5B/ANXA1/CTSL/SYT7/HUWE1/UVRAG/PIP4K2A/VAMP2/ARL8B 10 GO:0046785 microtubule polymerization 6/725 83/18722 0.102483100695676 0.278994005062503 AKAP9/CLIP1/MET/HSPA1A/NUMA1/RAC1 6 GO:0062013 positive regulation of small molecule metabolic process 9/725 143/18722 0.103828390439597 0.282504622189112 IGF2/APP/PMAIP1/DDB1/ANXA1/TMSB4X/ENO1/RDH10/HMGB1 9 GO:0006605 protein targeting 17/725 314/18722 0.103984858743784 0.282626943148655 TCAF1/NACA/HSPD1/HSPA8/STOM/LMAN1/BNIP3L/HSPA5/SEC62/HERPUD1/SIL1/HUWE1/HRAS/UBE2D3/SEC61B/SEC61G/SDCBP 17 GO:0060249 anatomical structure homeostasis 17/725 314/18722 0.103984858743784 0.282626943148655 ALDOA/ATP2B1/ITGB1/TFRC/AKR1B1/LAMC1/EGFR/GJA1/GAA/NF1/JAM3/HSPB1/HOMER1/ACTG1/BCL2/RAC1/B2M 17 GO:0045639 positive regulation of myeloid cell differentiation 7/725 103/18722 0.104771373433431 0.284552646203452 FOS/JUN/PRKDC/HSPA1A/RCOR1/FAM210B/HMGB1 7 GO:0017038 protein import 12/725 206/18722 0.104805640256825 0.284552646203452 HSPD1/HSPA8/CDH1/TXNIP/PTTG1IP/GLI3/PPP1R10/TNPO1/RANBP2/KPNB1/CDKN1A/CBLB 12 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 10/725 164/18722 0.104994721602792 0.284913406747619 CAV1/GNA12/NFE2L2/HERPUD1/HSPA1A/UFL1/MDM2/DDA1/EIF3H/SDCBP 10 GO:0003170 heart valve development 5/725 65/18722 0.106771170047036 0.288960523741818 RBPJ/SOX4/ROCK1/GJA5/MDM2 5 GO:0045682 regulation of epidermis development 5/725 65/18722 0.106771170047036 0.288960523741818 ROCK1/NCOA3/SRSF6/HES1/NUMA1 5 GO:0051310 metaphase plate congression 5/725 65/18722 0.106771170047036 0.288960523741818 DYNC1H1/KPNB1/NUMA1/RAB11A/CENPF 5 GO:0071677 positive regulation of mononuclear cell migration 5/725 65/18722 0.106771170047036 0.288960523741818 APP/RHOA/LGMN/HMGB1/SERPINE1 5 GO:1905330 regulation of morphogenesis of an epithelium 5/725 65/18722 0.106771170047036 0.288960523741818 LGR4/MAGED1/GJA1/BMP7/TACSTD2 5 GO:0010660 regulation of muscle cell apoptotic process 6/725 84/18722 0.106974354978686 0.289047444236118 PDCD4/NFE2L2/BMP7/PPP1R10/DNMT1/CFLAR 6 GO:0032508 DNA duplex unwinding 6/725 84/18722 0.106974354978686 0.289047444236118 ANXA1/ATRX/DHX36/RAD50/PURA/CHD4 6 GO:0061157 mRNA destabilization 6/725 84/18722 0.106974354978686 0.289047444236118 BTG2/DHX36/ROCK1/PUM1/TNRC6B/AGO2 6 GO:0009261 ribonucleotide catabolic process 4/725 47/18722 0.107859311190394 0.2894552952077 UPP1/PNP/PDE4B/HINT1 4 GO:0010799 regulation of peptidyl-threonine phosphorylation 4/725 47/18722 0.107859311190394 0.2894552952077 APP/CALM1/BMP7/RIPK2 4 GO:0019884 antigen processing and presentation of exogenous antigen 4/725 47/18722 0.107859311190394 0.2894552952077 CTSL/CTSV/LGMN/B2M 4 GO:0031641 regulation of myelination 4/725 47/18722 0.107859311190394 0.2894552952077 DAG1/CTSC/DICER1/DLG1 4 GO:0042311 vasodilation 4/725 47/18722 0.107859311190394 0.2894552952077 EGFR/ADRB1/GJA1/GJA5 4 GO:0045581 negative regulation of T cell differentiation 4/725 47/18722 0.107859311190394 0.2894552952077 ANXA1/GLI3/SOCS1/HMGB1 4 GO:0045646 regulation of erythrocyte differentiation 4/725 47/18722 0.107859311190394 0.2894552952077 PRKDC/HSPA1A/FAM210B/B2M 4 GO:0046677 response to antibiotic 4/725 47/18722 0.107859311190394 0.2894552952077 HSPA5/SLC9A1/MDM2/KDM5B 4 GO:0051489 regulation of filopodium assembly 4/725 47/18722 0.107859311190394 0.2894552952077 NEURL1/PPP1R9A/CDC42/CAPZB 4 GO:0097028 dendritic cell differentiation 4/725 47/18722 0.107859311190394 0.2894552952077 DHRS2/RBPJ/CEBPB/HMGB1 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/725 47/18722 0.107859311190394 0.2894552952077 LGR4/RBPJ/ARRDC3/DDIT3 4 GO:1903170 negative regulation of calcium ion transmembrane transport 4/725 47/18722 0.107859311190394 0.2894552952077 C4orf3/CALM1/SRI/GSTO1 4 GO:1902115 regulation of organelle assembly 11/725 186/18722 0.108180137941153 0.2894552952077 EZR/RHOA/NPM1/DYNC1H1/HSPA1A/GPSM2/RALB/PIP4K2A/NUMA1/CCSAP/SDCBP 11 GO:0007176 regulation of epidermal growth factor-activated receptor activity 3/725 30/18722 0.108609976619658 0.2894552952077 APP/NEURL1/CBLB 3 GO:0009264 deoxyribonucleotide catabolic process 3/725 30/18722 0.108609976619658 0.2894552952077 UPP1/PNP/TDG 3 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/725 30/18722 0.108609976619658 0.2894552952077 CALM1/SRI/GSTO1 3 GO:0043032 positive regulation of macrophage activation 3/725 30/18722 0.108609976619658 0.2894552952077 JUND/HSPD1/CTSC 3 GO:0044030 regulation of DNA methylation 3/725 30/18722 0.108609976619658 0.2894552952077 PARP1/MPHOSPH8/MBD3 3 GO:0044788 modulation by host of viral process 3/725 30/18722 0.108609976619658 0.2894552952077 HSPA8/STOM/CFL1 3 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 3/725 30/18722 0.108609976619658 0.2894552952077 EZR/PHPT1/CBLB 3 GO:0060351 cartilage development involved in endochondral bone morphogenesis 3/725 30/18722 0.108609976619658 0.2894552952077 GHR/TRIP11/SERPINH1 3 GO:0060603 mammary gland duct morphogenesis 3/725 30/18722 0.108609976619658 0.2894552952077 TBX3/LRP5/KDM5B 3 GO:0090314 positive regulation of protein targeting to membrane 3/725 30/18722 0.108609976619658 0.2894552952077 TCAF1/STOM/HRAS 3 GO:0140058 neuron projection arborization 3/725 30/18722 0.108609976619658 0.2894552952077 LRP2/MACF1/ROCK1 3 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 3/725 30/18722 0.108609976619658 0.2894552952077 HSPA5/UFL1/PPP1R15A 3 GO:2000648 positive regulation of stem cell proliferation 3/725 30/18722 0.108609976619658 0.2894552952077 GJA1/TBX3/N4BP2L2 3 GO:0071695 anatomical structure maturation 13/725 229/18722 0.109170276366294 0.290795654703492 APP/DAG1/AKR1B1/RBPJ/RHOA/TFCP2L1/BCL2/RERE/ATP6AP2/FAM210B/CDKN1A/HES1/DDIT3 13 GO:0002695 negative regulation of leukocyte activation 11/725 187/18722 0.111174806843835 0.295024328258934 DLG5/ANXA1/GRN/GLI3/SOCS1/CEBPB/DLG1/INHA/HMGB1/ARG2/CBLB 11 GO:0061013 regulation of mRNA catabolic process 10/725 166/18722 0.111328255252971 0.295024328258934 FUS/BTG2/NPM1/DHX36/ROCK1/PUM1/LARP1/TNRC6B/AGO2/YBX1 10 GO:0032092 positive regulation of protein binding 6/725 85/18722 0.11156564049838 0.295024328258934 CAV1/LRP1/APP/RALB/RIPK2/B2M 6 GO:0044774 mitotic DNA integrity checkpoint signaling 6/725 85/18722 0.11156564049838 0.295024328258934 PRKDC/SOX4/RPL26/PPP1R10/MDM2/CDKN1A 6 GO:0030193 regulation of blood coagulation 5/725 66/18722 0.11206617533175 0.295024328258934 CAV1/NFE2L2/C1QTNF1/SERPINB2/SERPINE1 5 GO:0045600 positive regulation of fat cell differentiation 5/725 66/18722 0.11206617533175 0.295024328258934 LRP5/BMP7/CEBPB/CDS1/ADIRF 5 GO:0050918 positive chemotaxis 5/725 66/18722 0.11206617533175 0.295024328258934 LRP1/MIF/MET/PGF/HMGB1 5 GO:0050922 negative regulation of chemotaxis 5/725 66/18722 0.11206617533175 0.295024328258934 MIF/SEMA6D/SEMA6A/DUSP1/SEMA4C 5 GO:0070585 protein localization to mitochondrion 8/725 125/18722 0.112356311827978 0.295024328258934 HSPD1/LMAN1/CALM1/BNIP3L/NMT1/HUWE1/UBE2D3/DDIT3 8 GO:0002679 respiratory burst involved in defense response 2/725 15/18722 0.11279486055747 0.295024328258934 GRN/RPS19 2 GO:0006878 cellular copper ion homeostasis 2/725 15/18722 0.11279486055747 0.295024328258934 APP/ARF1 2 GO:0019511 peptidyl-proline hydroxylation 2/725 15/18722 0.11279486055747 0.295024328258934 P4HB/ERO1A 2 GO:0030252 growth hormone secretion 2/725 15/18722 0.11279486055747 0.295024328258934 SERP1/RAB1A 2 GO:0035493 SNARE complex assembly 2/725 15/18722 0.11279486055747 0.295024328258934 UVRAG/VAMP2 2 GO:0035627 ceramide transport 2/725 15/18722 0.11279486055747 0.295024328258934 ABCB1/PSAP 2 GO:0042976 activation of Janus kinase activity 2/725 15/18722 0.11279486055747 0.295024328258934 SOCS1/GHR 2 GO:0042994 cytoplasmic sequestering of transcription factor 2/725 15/18722 0.11279486055747 0.295024328258934 TMSB4X/SRI 2 GO:0043584 nose development 2/725 15/18722 0.11279486055747 0.295024328258934 GLI3/RDH10 2 GO:0045475 locomotor rhythm 2/725 15/18722 0.11279486055747 0.295024328258934 ZFHX3/NCOA2 2 GO:0050746 regulation of lipoprotein metabolic process 2/725 15/18722 0.11279486055747 0.295024328258934 ITGAV/DBI 2 GO:0051938 L-glutamate import 2/725 15/18722 0.11279486055747 0.295024328258934 ITGB1/ARL6IP5 2 GO:0060253 negative regulation of glial cell proliferation 2/725 15/18722 0.11279486055747 0.295024328258934 DICER1/HES1 2 GO:0060413 atrial septum morphogenesis 2/725 15/18722 0.11279486055747 0.295024328258934 ISL1/SOX4 2 GO:0071474 cellular hyperosmotic response 2/725 15/18722 0.11279486055747 0.295024328258934 AKR1B1/EFHD1 2 GO:0071871 response to epinephrine 2/725 15/18722 0.11279486055747 0.295024328258934 PDE4B/SLC9A1 2 GO:0072044 collecting duct development 2/725 15/18722 0.11279486055747 0.295024328258934 DLG5/AKR1B1 2 GO:0072075 metanephric mesenchyme development 2/725 15/18722 0.11279486055747 0.295024328258934 BASP1/BMP7 2 GO:0098712 L-glutamate import across plasma membrane 2/725 15/18722 0.11279486055747 0.295024328258934 ITGB1/ARL6IP5 2 GO:1901660 calcium ion export 2/725 15/18722 0.11279486055747 0.295024328258934 ATP2B1/CALM1 2 GO:1904424 regulation of GTP binding 2/725 15/18722 0.11279486055747 0.295024328258934 MET/CCPG1 2 GO:1905146 lysosomal protein catabolic process 2/725 15/18722 0.11279486055747 0.295024328258934 LRP1/LRP2 2 GO:1905168 positive regulation of double-strand break repair via homologous recombination 2/725 15/18722 0.11279486055747 0.295024328258934 FUS/PARP1 2 GO:1905288 vascular associated smooth muscle cell apoptotic process 2/725 15/18722 0.11279486055747 0.295024328258934 PDCD4/DNMT1 2 GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process 2/725 15/18722 0.11279486055747 0.295024328258934 PDCD4/DNMT1 2 GO:1990822 basic amino acid transmembrane transport 2/725 15/18722 0.11279486055747 0.295024328258934 SLC7A6/SLC38A9 2 GO:0062207 regulation of pattern recognition receptor signaling pathway 7/725 105/18722 0.112939929105965 0.295251418585939 CAV1/LGR4/PUM1/HSPA1A/RTN4/HMGB1/CYBA 7 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 12/725 209/18722 0.113256759755426 0.295927069690854 SERPINB9/PMAIP1/S100A9/DHCR24/HSPD1/PDCD6/RHOA/HERPUD1/ARL6IP5/MDM2/CFLAR/HMGB1 12 GO:0002237 response to molecule of bacterial origin 19/725 363/18722 0.113968224263671 0.297195941516366 FOS/JUN/JUND/S100A9/HSPD1/GJA1/PDCD4/RHOA/PDE4B/CEBPB/GNG12/PABPN1/ADH5/CD55/SASH1/RIPK2/HMGB1/SERPINE1/B2M 19 GO:0010675 regulation of cellular carbohydrate metabolic process 9/725 146/18722 0.114079848891611 0.297195941516366 IGF2/PMAIP1/DDB1/PHLDA2/SLC35B4/RANBP2/C1QTNF1/NCOA2/HMGB1 9 GO:0045580 regulation of T cell differentiation 9/725 146/18722 0.114079848891611 0.297195941516366 CD46/ANXA1/PNP/SOX4/GLI3/RHOA/SOCS1/RIPK2/HMGB1 9 GO:0030308 negative regulation of cell growth 11/725 188/18722 0.114216788794076 0.297195941516366 SEMA6D/SEMA6A/GJA1/ENO1/SPAG9/BCL2/HSPA1A/SERTAD2/CDKN1A/SEMA4C/RTN4 11 GO:0015804 neutral amino acid transport 4/725 48/18722 0.114270051295206 0.297195941516366 SLC38A1/SLC38A9/MFSD12/SLC7A5 4 GO:0048146 positive regulation of fibroblast proliferation 4/725 48/18722 0.114270051295206 0.297195941516366 MIF/PRKDC/CDKN1A/S100A6 4 GO:0061647 histone H3-K9 modification 4/725 48/18722 0.114270051295206 0.297195941516366 ATRX/ZNF451/ASH1L/DNMT1 4 GO:1903053 regulation of extracellular matrix organization 4/725 48/18722 0.114270051295206 0.297195941516366 LRP1/DAG1/PHLDB2/CFLAR 4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 4/725 48/18722 0.114270051295206 0.297195941516366 CAV1/PMAIP1/ATF3/TIMP3 4 GO:0050727 regulation of inflammatory response 20/725 386/18722 0.115151868475008 0.299335805794776 NEAT1/BRD4/APP/S100A9/HSPD1/CTSC/EGFR/ANXA1/ISL1/PDCD4/TMSB4X/GRN/IL6ST/RPS19/ASH1L/GPX4/CEBPB/UFL1/SERPINF1/SERPINE1 20 GO:0002685 regulation of leukocyte migration 12/725 210/18722 0.11615920788781 0.301432253966397 MIF/APP/DUSP1/ANXA1/PGF/RHOA/JAM3/LGMN/HMGB1/CD99/SERPINE1/RAC1 12 GO:0050866 negative regulation of cell activation 12/725 210/18722 0.11615920788781 0.301432253966397 DLG5/ANXA1/GRN/GLI3/SOCS1/CEBPB/DLG1/C1QTNF1/INHA/HMGB1/ARG2/CBLB 12 GO:0009798 axis specification 6/725 86/18722 0.116255682877156 0.301432253966397 WLS/BASP1/TBX3/GPC3/COBL/DDIT3 6 GO:0032413 negative regulation of ion transmembrane transporter activity 6/725 86/18722 0.116255682877156 0.301432253966397 C4orf3/CAV1/CALM1/GOPC/SRI/GSTO1 6 GO:2001251 negative regulation of chromosome organization 6/725 86/18722 0.116255682877156 0.301432253966397 DUSP1/PARP1/ATRX/RAD50/HNRNPA1/CENPF 6 GO:0006613 cotranslational protein targeting to membrane 3/725 31/18722 0.116967046711797 0.301889021002535 SEC62/SIL1/SEC61B 3 GO:0030201 heparan sulfate proteoglycan metabolic process 3/725 31/18722 0.116967046711797 0.301889021002535 EXTL2/B3GAT3/GLCE 3 GO:0035510 DNA dealkylation 3/725 31/18722 0.116967046711797 0.301889021002535 TET2/TDG/USP9X 3 GO:0051443 positive regulation of ubiquitin-protein transferase activity 3/725 31/18722 0.116967046711797 0.301889021002535 ARRDC3/RPS2/SKP1 3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/725 31/18722 0.116967046711797 0.301889021002535 CFLAR/SERPINE1/TMBIM1 3 GO:2000144 positive regulation of DNA-templated transcription, initiation 3/725 31/18722 0.116967046711797 0.301889021002535 JUN/DHX36/SUB1 3 GO:0001824 blastocyst development 7/725 106/18722 0.117146518901556 0.301889021002535 RPL13/NASP/N4BP2L2/RTF1/HOPX/RTN4/UBE2A 7 GO:0006906 vesicle fusion 7/725 106/18722 0.117146518901556 0.301889021002535 KIF5B/ANXA1/SYT7/UVRAG/PIP4K2A/VAMP2/ARL8B 7 GO:0035821 modulation of process of other organism 7/725 106/18722 0.117146518901556 0.301889021002535 SERPINB9/DAG1/JUN/S100A9/HSPA8/STOM/CFL1 7 GO:0042116 macrophage activation 7/725 106/18722 0.117146518901556 0.301889021002535 MIF/APP/JUND/HSPD1/CTSC/GRN/HMGB1 7 GO:0071887 leukocyte apoptotic process 7/725 106/18722 0.117146518901556 0.301889021002535 SLC39A10/RPS6/ANXA1/GLI3/CTSL/PIK3CB/ARG2 7 GO:1903707 negative regulation of hemopoiesis 7/725 106/18722 0.117146518901556 0.301889021002535 FBN1/ANXA1/FSTL3/GLI3/SOCS1/INHA/HMGB1 7 GO:0046578 regulation of Ras protein signal transduction 11/725 189/18722 0.117305896286295 0.30199430444545 ITGB1/ADGRG1/KANK1/MET/EPS8L1/NET1/HRAS/RASA1/RAC1/PIK3CB/TIMP2 11 GO:0006402 mRNA catabolic process 13/725 232/18722 0.117375552499745 0.30199430444545 FUS/DDX5/BTG2/NPM1/DHX36/ROCK1/PUM1/LARP1/HSPA1A/TNRC6B/UPF2/AGO2/YBX1 13 GO:0009880 embryonic pattern specification 5/725 67/18722 0.117485257124961 0.30199430444545 NRP2/BASP1/TBX3/BMP7/COBL 5 GO:0042130 negative regulation of T cell proliferation 5/725 67/18722 0.117485257124961 0.30199430444545 DLG5/CEBPB/DLG1/ARG2/CBLB 5 GO:1903317 regulation of protein maturation 5/725 67/18722 0.117485257124961 0.30199430444545 GLG1/SOX4/ENO1/MDM2/SERPINE1 5 GO:0006839 mitochondrial transport 14/725 254/18722 0.118026640457955 0.303232154324061 PMAIP1/HSPD1/LMAN1/BNIP3L/SLC25A36/NMT1/BCL2/AFG3L2/HSPA1A/SLC9A1/MPC2/HUWE1/UBE2D3/CHCHD10 14 GO:0032496 response to lipopolysaccharide 18/725 343/18722 0.119280137510421 0.306297374387196 FOS/JUN/JUND/S100A9/HSPD1/GJA1/PDCD4/RHOA/PDE4B/CEBPB/GNG12/PABPN1/ADH5/CD55/SASH1/RIPK2/HMGB1/SERPINE1 18 GO:0099111 microtubule-based transport 11/725 190/18722 0.120441920419098 0.308827790092044 ARMCX3/APP/KIF5B/HSPA8/DST/DYNC1H1/HSPB1/CDC42/PURA/RAB1A/ARL8B 11 GO:0006338 chromatin remodeling 14/725 255/18722 0.120717461634385 0.308827790092044 NASP/NPM1/BPTF/ATRX/HP1BP3/RERE/KDM5A/BRD2/BAZ1B/KDM5B/SETD2/CHD4/MBD3/SMARCA1 14 GO:0007602 phototransduction 4/725 49/18722 0.120844155303013 0.308827790092044 OPN3/NMT1/GNAQ/CDS1 4 GO:0030225 macrophage differentiation 4/725 49/18722 0.120844155303013 0.308827790092044 APP/PARP1/CDC42/INHA 4 GO:0030857 negative regulation of epithelial cell differentiation 4/725 49/18722 0.120844155303013 0.308827790092044 CAV1/TBX3/SRSF6/HES1 4 GO:0048168 regulation of neuronal synaptic plasticity 4/725 49/18722 0.120844155303013 0.308827790092044 APP/NEURL1/HRAS/RAB11A 4 GO:0052372 modulation by symbiont of entry into host 4/725 49/18722 0.120844155303013 0.308827790092044 CAV1/ITGAV/P4HB/LY6E 4 GO:0072091 regulation of stem cell proliferation 4/725 49/18722 0.120844155303013 0.308827790092044 FBLN1/GJA1/TBX3/N4BP2L2 4 GO:1990928 response to amino acid starvation 4/725 49/18722 0.120844155303013 0.308827790092044 TFEB/LARP1/CDKN1A/ATF3 4 GO:0002683 negative regulation of immune system process 22/725 434/18722 0.120874794938373 0.308827790092044 SERPINB9/FBN1/DLG5/CD46/MIF/PRKDC/DUSP1/ANXA1/FSTL3/GRN/EZR/GLI3/RPS19/SOCS1/CEBPB/DLG1/CD55/INHA/HMGB1/PHPT1/ARG2/CBLB 22 GO:0061014 positive regulation of mRNA catabolic process 6/725 87/18722 0.121043116783022 0.309102044822739 BTG2/DHX36/ROCK1/PUM1/TNRC6B/AGO2 6 GO:0018394 peptidyl-lysine acetylation 10/725 169/18722 0.121225025241898 0.309410701385289 ISL1/SOX4/ZNF451/BRD7/NCOA3/PHF20/USP22/EID1/MBD3/MORF4L2 10 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 5/725 68/18722 0.123025975636449 0.311680358344131 ISL1/CSH1/IL6ST/GHR/HES1 5 GO:0051926 negative regulation of calcium ion transport 5/725 68/18722 0.123025975636449 0.311680358344131 C4orf3/CALM1/BCL2/SRI/GSTO1 5 GO:1900046 regulation of hemostasis 5/725 68/18722 0.123025975636449 0.311680358344131 CAV1/NFE2L2/C1QTNF1/SERPINB2/SERPINE1 5 GO:1901016 regulation of potassium ion transmembrane transporter activity 5/725 68/18722 0.123025975636449 0.311680358344131 AKAP9/CAV1/ITGB1/DLG1/VAMP2 5 GO:1904888 cranial skeletal system development 5/725 68/18722 0.123025975636449 0.311680358344131 GLI3/RDH10/NIPBL/TFAP2A/SETD2 5 GO:0006401 RNA catabolic process 15/725 278/18722 0.1234221744073 0.311680358344131 FUS/KCNQ1OT1/DDX5/BTG2/NPM1/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/TNRC6B/UPF2/AGO2/YBX1 15 GO:0090596 sensory organ morphogenesis 14/725 256/18722 0.123443666185594 0.311680358344131 FBN1/FBN2/TENM3/EFEMP1/TRIOBP/GLI3/LRP5/NF1/BMP7/BCL2/NIPBL/C12orf57/TFAP2A/RDH13 14 GO:0032612 interleukin-1 production 8/725 128/18722 0.123991487049627 0.311680358344131 APP/ANXA1/ISL1/HSPB1/SERPINB1/RIPK2/HMGB1/ARG2 8 GO:0032652 regulation of interleukin-1 production 8/725 128/18722 0.123991487049627 0.311680358344131 APP/ANXA1/ISL1/HSPB1/SERPINB1/RIPK2/HMGB1/ARG2 8 GO:0043487 regulation of RNA stability 10/725 170/18722 0.1246285484316 0.311680358344131 FUS/BTG2/NPM1/DHX36/ROCK1/PUM1/LARP1/TNRC6B/AGO2/YBX1 10 GO:0016525 negative regulation of angiogenesis 9/725 149/18722 0.124869158826584 0.311680358344131 SEMA6A/ADAMTS1/ROCK1/COL4A2/GTF2I/SERPINF1/AMOT/SERPINE1/PIK3CB 9 GO:0009954 proximal/distal pattern formation 3/725 32/18722 0.125555384390554 0.311680358344131 GLI3/PBX1/IRX2 3 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 3/725 32/18722 0.125555384390554 0.311680358344131 NFE2L2/PPP1R10/CFLAR 3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 3/725 32/18722 0.125555384390554 0.311680358344131 TGFBR3/CDKN1C/SDCBP 3 GO:0042744 hydrogen peroxide catabolic process 3/725 32/18722 0.125555384390554 0.311680358344131 GPX3/PRDX6/CAT 3 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 3/725 32/18722 0.125555384390554 0.311680358344131 ANXA1/SOCS1/RIPK2 3 GO:0045761 regulation of adenylate cyclase activity 3/725 32/18722 0.125555384390554 0.311680358344131 AKAP9/NF1/TIMP2 3 GO:0048841 regulation of axon extension involved in axon guidance 3/725 32/18722 0.125555384390554 0.311680358344131 SEMA6D/SEMA6A/SEMA4C 3 GO:0071875 adrenergic receptor signaling pathway 3/725 32/18722 0.125555384390554 0.311680358344131 ADRB1/ARRDC3/PDE4B 3 GO:1900745 positive regulation of p38MAPK cascade 3/725 32/18722 0.125555384390554 0.311680358344131 MAP3K4/GADD45B/SASH1 3 GO:1901889 negative regulation of cell junction assembly 3/725 32/18722 0.125555384390554 0.311680358344131 LRP1/ROCK1/PHLDB2 3 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 3/725 32/18722 0.125555384390554 0.311680358344131 TGFBR3/CDKN1C/SDCBP 3 GO:1905476 negative regulation of protein localization to membrane 3/725 32/18722 0.125555384390554 0.311680358344131 CLTC/GOPC/TMBIM1 3 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3/725 32/18722 0.125555384390554 0.311680358344131 ANXA1/HMGB1/ARG2 3 GO:0001845 phagolysosome assembly 2/725 16/18722 0.125734480048938 0.311680358344131 SYT7/ARL8B 2 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2/725 16/18722 0.125734480048938 0.311680358344131 ENPEP/ATP6AP2 2 GO:0002693 positive regulation of cellular extravasation 2/725 16/18722 0.125734480048938 0.311680358344131 JAM3/CD99 2 GO:0002713 negative regulation of B cell mediated immunity 2/725 16/18722 0.125734480048938 0.311680358344131 CD46/CD55 2 GO:0002890 negative regulation of immunoglobulin mediated immune response 2/725 16/18722 0.125734480048938 0.311680358344131 CD46/CD55 2 GO:0002921 negative regulation of humoral immune response 2/725 16/18722 0.125734480048938 0.311680358344131 CD46/CD55 2 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 2/725 16/18722 0.125734480048938 0.311680358344131 RBPJ/ENG 2 GO:0006349 regulation of gene expression by genetic imprinting 2/725 16/18722 0.125734480048938 0.311680358344131 IGF2/DNMT3A 2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2/725 16/18722 0.125734480048938 0.311680358344131 RPL26/CDKN1A 2 GO:0009642 response to light intensity 2/725 16/18722 0.125734480048938 0.311680358344131 CAT/RDH13 2 GO:0010225 response to UV-C 2/725 16/18722 0.125734480048938 0.311680358344131 MAP3K4/MDM2 2 GO:0014819 regulation of skeletal muscle contraction 2/725 16/18722 0.125734480048938 0.311680358344131 C12orf57/GSTO1 2 GO:0030540 female genitalia development 2/725 16/18722 0.125734480048938 0.311680358344131 LRP2/TBX3 2 GO:0033631 cell-cell adhesion mediated by integrin 2/725 16/18722 0.125734480048938 0.311680358344131 ITGB1/PLPP3 2 GO:0034138 toll-like receptor 3 signaling pathway 2/725 16/18722 0.125734480048938 0.311680358344131 CAV1/COLEC12 2 GO:0035751 regulation of lysosomal lumen pH 2/725 16/18722 0.125734480048938 0.311680358344131 GRN/ATP6AP2 2 GO:0042407 cristae formation 2/725 16/18722 0.125734480048938 0.311680358344131 AFG3L2/CHCHD10 2 GO:0042574 retinal metabolic process 2/725 16/18722 0.125734480048938 0.311680358344131 RDH10/RDH13 2 GO:0048557 embryonic digestive tract morphogenesis 2/725 16/18722 0.125734480048938 0.311680358344131 GLI3/NIPBL 2 GO:0050884 neuromuscular process controlling posture 2/725 16/18722 0.125734480048938 0.311680358344131 TMEM150C/GAA 2 GO:0060572 morphogenesis of an epithelial bud 2/725 16/18722 0.125734480048938 0.311680358344131 BMP7/RDH10 2 GO:0061684 chaperone-mediated autophagy 2/725 16/18722 0.125734480048938 0.311680358344131 EEF1A1/HSPA8 2 GO:0070365 hepatocyte differentiation 2/725 16/18722 0.125734480048938 0.311680358344131 KRT18/ANXA1 2 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 2/725 16/18722 0.125734480048938 0.311680358344131 HSPA1A/RIPK2 2 GO:0071391 cellular response to estrogen stimulus 2/725 16/18722 0.125734480048938 0.311680358344131 SERPINB9/MDM2 2 GO:0071732 cellular response to nitric oxide 2/725 16/18722 0.125734480048938 0.311680358344131 MTR/CFLAR 2 GO:0072109 glomerular mesangium development 2/725 16/18722 0.125734480048938 0.311680358344131 BMP7/CFLAR 2 GO:0072148 epithelial cell fate commitment 2/725 16/18722 0.125734480048938 0.311680358344131 NR2F2/RBPJ 2 GO:0080009 mRNA methylation 2/725 16/18722 0.125734480048938 0.311680358344131 ZC3H13/CMTR1 2 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2/725 16/18722 0.125734480048938 0.311680358344131 VAMP2/RAB11A 2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 2/725 16/18722 0.125734480048938 0.311680358344131 SEMA6A/PIK3CB 2 GO:1901201 regulation of extracellular matrix assembly 2/725 16/18722 0.125734480048938 0.311680358344131 DAG1/PHLDB2 2 GO:1902570 protein localization to nucleolus 2/725 16/18722 0.125734480048938 0.311680358344131 GLUL/NPM1 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/725 16/18722 0.125734480048938 0.311680358344131 ZNRF3/GPC3 2 GO:0007173 epidermal growth factor receptor signaling pathway 7/725 108/18722 0.125800028618913 0.311680358344131 EGFR/EFEMP1/NEURL1/IQGAP1/PTPN12/ARF4/CBLB 7 GO:0009144 purine nucleoside triphosphate metabolic process 6/725 88/18722 0.125926489226431 0.311680358344131 ALDOA/PARP1/TMSB4X/RHOA/ENO1/AK3 6 GO:0031110 regulation of microtubule polymerization or depolymerization 6/725 88/18722 0.125926489226431 0.311680358344131 AKAP9/CLIP1/MET/HSPA1A/NUMA1/RAC1 6 GO:0050779 RNA destabilization 6/725 88/18722 0.125926489226431 0.311680358344131 BTG2/DHX36/ROCK1/PUM1/TNRC6B/AGO2 6 GO:0007632 visual behavior 4/725 50/18722 0.127576611886757 0.314688975987334 ITGB1/APP/NF1/DYNLRB1 4 GO:0043268 positive regulation of potassium ion transport 4/725 50/18722 0.127576611886757 0.314688975987334 AKAP9/KIF5B/KCNN4/DLG1 4 GO:0045058 T cell selection 4/725 50/18722 0.127576611886757 0.314688975987334 GLI3/CTSL/RHOA/BCL2 4 GO:0045814 negative regulation of gene expression, epigenetic 4/725 50/18722 0.127576611886757 0.314688975987334 MPHOSPH8/DNMT3A/DNMT1/MBD3 4 GO:0050873 brown fat cell differentiation 4/725 50/18722 0.127576611886757 0.314688975987334 ADRB1/BMP7/CEBPB/ERO1A 4 GO:1904036 negative regulation of epithelial cell apoptotic process 4/725 50/18722 0.127576611886757 0.314688975987334 NFE2L2/SRSF6/CFLAR/SERPINE1 4 GO:2000677 regulation of transcription regulatory region DNA binding 4/725 50/18722 0.127576611886757 0.314688975987334 PARP1/TMSB4X/DDIT3/SRI 4 GO:0007093 mitotic cell cycle checkpoint signaling 8/725 129/18722 0.128005380022113 0.315439606870243 PRKDC/DUSP1/SOX4/RPL26/PPP1R10/MDM2/CDKN1A/CENPF 8 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 8/725 129/18722 0.128005380022113 0.315439606870243 PMAIP1/S100A9/HSPD1/PDCD6/RHOA/ARL6IP5/CFLAR/HMGB1 8 GO:0051056 regulation of small GTPase mediated signal transduction 16/725 302/18722 0.128164578688201 0.315678449645525 ITGB1/ADGRG1/KANK1/ITGAV/ARHGAP18/MET/EPS8L1/ARHGAP32/ARHGAP23/NET1/HRAS/AMOT/RASA1/RAC1/PIK3CB/TIMP2 16 GO:0006368 transcription elongation from RNA polymerase II promoter 5/725 69/18722 0.128685764349142 0.316654436643592 BRD4/SERTAD1/RTF1/SERTAD2/SETD2 5 GO:0007004 telomere maintenance via telomerase 5/725 69/18722 0.128685764349142 0.316654436643592 MAP3K4/PKIB/RAD50/HNRNPA1/NOP10 5 GO:0042593 glucose homeostasis 14/725 258/18722 0.129001732794596 0.317277915349737 DYNLL1/LRP1/KIF5B/RPS6/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 14 GO:0006821 chloride transport 7/725 109/18722 0.130245047493139 0.320025276656675 SLC26A2/CLIC3/FXYD3/GABRE/ABCB1/CLDN4/CLIC1 7 GO:0034766 negative regulation of ion transmembrane transport 7/725 109/18722 0.130245047493139 0.320025276656675 C4orf3/CAV1/CALM1/ARL6IP5/GOPC/SRI/GSTO1 7 GO:0009199 ribonucleoside triphosphate metabolic process 6/725 89/18722 0.130904262932278 0.321333515159185 ALDOA/PARP1/TMSB4X/RHOA/ENO1/AK3 6 GO:0010657 muscle cell apoptotic process 6/725 89/18722 0.130904262932278 0.321333515159185 PDCD4/NFE2L2/BMP7/PPP1R10/DNMT1/CFLAR 6 GO:0050804 modulation of chemical synaptic transmission 22/725 439/18722 0.131424447898953 0.322454272216744 AKAP9/ITGB1/APP/KIF5B/EGFR/CDH1/NEURL1/CALM1/PTPRA/PPP1R9A/SLC6A4/GLUL/HOMER1/LGMN/RPL22/SYT7/ERC1/HRAS/VAMP2/RAB11A/ARF1/PAIP2 22 GO:0002221 pattern recognition receptor signaling pathway 10/725 172/18722 0.131590488482926 0.322705460145115 CAV1/LGR4/HSPD1/COLEC12/PUM1/HSPA1A/RTN4/RIPK2/HMGB1/CYBA 10 GO:0033500 carbohydrate homeostasis 14/725 259/18722 0.131833318813809 0.323144629142745 DYNLL1/LRP1/KIF5B/RPS6/SOX4/LRP5/TRA2B/HMGN3/MPC2/SERPINF1/SRI/PHPT1/RAC1/CYBA 14 GO:0030902 hindbrain development 9/725 151/18722 0.132355191297939 0.324110369415098 WLS/ITGB1/SLC6A4/BMP7/HSPA5/BCL2/RERE/HES1/SEMA4C 9 GO:2000181 negative regulation of blood vessel morphogenesis 9/725 151/18722 0.132355191297939 0.324110369415098 SEMA6A/ADAMTS1/ROCK1/COL4A2/GTF2I/SERPINF1/AMOT/SERPINE1/PIK3CB 9 GO:0099177 regulation of trans-synaptic signaling 22/725 440/18722 0.133598182779558 0.326079560306738 AKAP9/ITGB1/APP/KIF5B/EGFR/CDH1/NEURL1/CALM1/PTPRA/PPP1R9A/SLC6A4/GLUL/HOMER1/LGMN/RPL22/SYT7/ERC1/HRAS/VAMP2/RAB11A/ARF1/PAIP2 22 GO:0010165 response to X-ray 3/725 33/18722 0.134362389999936 0.326079560306738 ANXA1/NIPBL/CDKN1A 3 GO:0010259 multicellular organism aging 3/725 33/18722 0.134362389999936 0.326079560306738 CTSV/TFCP2L1/SERP1 3 GO:0032633 interleukin-4 production 3/725 33/18722 0.134362389999936 0.326079560306738 CEBPB/DDIT3/SLC7A5 3 GO:0032673 regulation of interleukin-4 production 3/725 33/18722 0.134362389999936 0.326079560306738 CEBPB/DDIT3/SLC7A5 3 GO:0034110 regulation of homotypic cell-cell adhesion 3/725 33/18722 0.134362389999936 0.326079560306738 IL6ST/C1QTNF1/ZNF703 3 GO:0035025 positive regulation of Rho protein signal transduction 3/725 33/18722 0.134362389999936 0.326079560306738 ADGRG1/NET1/RAC1 3 GO:0045648 positive regulation of erythrocyte differentiation 3/725 33/18722 0.134362389999936 0.326079560306738 PRKDC/HSPA1A/FAM210B 3 GO:0048333 mesodermal cell differentiation 3/725 33/18722 0.134362389999936 0.326079560306738 ITGB1/ITGB4/GJA1 3 GO:0060122 inner ear receptor cell stereocilium organization 3/725 33/18722 0.134362389999936 0.326079560306738 TRIOBP/TRIP11/HES1 3 GO:0070570 regulation of neuron projection regeneration 3/725 33/18722 0.134362389999936 0.326079560306738 LRP1/GRN/PTPRF 3 GO:0071353 cellular response to interleukin-4 3/725 33/18722 0.134362389999936 0.326079560306738 RPLP0/HSPA5/RPL3 3 GO:0071539 protein localization to centrosome 3/725 33/18722 0.134362389999936 0.326079560306738 GOLGB1/HOOK3/CEP350 3 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 3/725 33/18722 0.134362389999936 0.326079560306738 KANK1/TACSTD2/CAPZB 3 GO:0150117 positive regulation of cell-substrate junction organization 3/725 33/18722 0.134362389999936 0.326079560306738 ROCK1/IQGAP1/RAC1 3 GO:2000036 regulation of stem cell population maintenance 3/725 33/18722 0.134362389999936 0.326079560306738 ZC3H13/BMP7/NCOA3 3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4/725 51/18722 0.134462239253185 0.326079560306738 RHOA/ASH1L/USP10/TLE1 4 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 4/725 51/18722 0.134462239253185 0.326079560306738 ANXA1/SOCS1/RIPK2/HMGB1 4 GO:0045104 intermediate filament cytoskeleton organization 4/725 51/18722 0.134462239253185 0.326079560306738 KRT18/DST/MACF1/PLEC 4 GO:0051339 regulation of lyase activity 4/725 51/18722 0.134462239253185 0.326079560306738 AKAP9/NF1/PHPT1/TIMP2 4 GO:0002698 negative regulation of immune effector process 7/725 110/18722 0.134767543665933 0.326079560306738 SERPINB9/CD46/PRKDC/ANXA1/GRN/RPS19/CD55 7 GO:0009408 response to heat 7/725 110/18722 0.134767543665933 0.326079560306738 HSPD1/PDCD6/SLC52A3/DHX36/HSPA1A/DNAJB4/CDKN1A 7 GO:0032611 interleukin-1 beta production 7/725 110/18722 0.134767543665933 0.326079560306738 APP/ISL1/HSPB1/SERPINB1/RIPK2/HMGB1/ARG2 7 GO:0032651 regulation of interleukin-1 beta production 7/725 110/18722 0.134767543665933 0.326079560306738 APP/ISL1/HSPB1/SERPINB1/RIPK2/HMGB1/ARG2 7 GO:0090174 organelle membrane fusion 7/725 110/18722 0.134767543665933 0.326079560306738 KIF5B/ANXA1/SYT7/UVRAG/PIP4K2A/VAMP2/ARL8B 7 GO:0006694 steroid biosynthetic process 10/725 173/18722 0.135148145791652 0.326844442279525 CYP11A1/AKR1B1/DHCR24/SF1/SLC27A2/PBX1/HSD3B1/HSD17B1/CYP19A1/FDX1 10 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 6/725 90/18722 0.135974819776396 0.328373683395212 CAV1/NFE2L2/HERPUD1/HSPA1A/MDM2/DDA1 6 GO:0042475 odontogenesis of dentin-containing tooth 6/725 90/18722 0.135974819776396 0.328373683395212 CSF3R/LAMA5/ANKRD11/GLI3/BMP7/SERPINE1 6 GO:0097581 lamellipodium organization 6/725 90/18722 0.135974819776396 0.328373683395212 ITGB1/KANK1/WASF2/CDC42/RAC1/CAPZB 6 GO:0016573 histone acetylation 9/725 152/18722 0.136184658582439 0.328526046073186 ISL1/ZNF451/BRD7/NCOA3/PHF20/USP22/EID1/MBD3/MORF4L2 9 GO:1901343 negative regulation of vasculature development 9/725 152/18722 0.136184658582439 0.328526046073186 SEMA6A/ADAMTS1/ROCK1/COL4A2/GTF2I/SERPINF1/AMOT/SERPINE1/PIK3CB 9 GO:0018022 peptidyl-lysine methylation 8/725 131/18722 0.136232343429836 0.328526046073186 BRD4/KMT2C/TET2/ATRX/ASH1L/RTF1/DNMT1/SETD2 8 GO:0006163 purine nucleotide metabolic process 20/725 396/18722 0.137470094254756 0.330181628333577 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3 20 GO:0006390 mitochondrial transcription 2/725 17/18722 0.139003273794408 0.330181628333577 TFAM/CHCHD10 2 GO:0007351 tripartite regional subdivision 2/725 17/18722 0.139003273794408 0.330181628333577 BASP1/TBX3 2 GO:0007379 segment specification 2/725 17/18722 0.139003273794408 0.330181628333577 COBL/IRX2 2 GO:0008595 anterior/posterior axis specification, embryo 2/725 17/18722 0.139003273794408 0.330181628333577 BASP1/TBX3 2 GO:0010224 response to UV-B 2/725 17/18722 0.139003273794408 0.330181628333577 BCL2/CDKN1A 2 GO:0010470 regulation of gastrulation 2/725 17/18722 0.139003273794408 0.330181628333577 DAG1/PHLDB2 2 GO:0020027 hemoglobin metabolic process 2/725 17/18722 0.139003273794408 0.330181628333577 CAT/INHA 2 GO:0021924 cell proliferation in external granule layer 2/725 17/18722 0.139003273794408 0.330181628333577 SLC6A4/RERE 2 GO:0021930 cerebellar granule cell precursor proliferation 2/725 17/18722 0.139003273794408 0.330181628333577 SLC6A4/RERE 2 GO:0030322 stabilization of membrane potential 2/725 17/18722 0.139003273794408 0.330181628333577 KCNN4/CHCHD10 2 GO:0031445 regulation of heterochromatin assembly 2/725 17/18722 0.139003273794408 0.330181628333577 MPHOSPH8/DNMT1 2 GO:0033151 V(D)J recombination 2/725 17/18722 0.139003273794408 0.330181628333577 PRKDC/HMGB1 2 GO:0035518 histone H2A monoubiquitination 2/725 17/18722 0.139003273794408 0.330181628333577 DDB1/SKP1 2 GO:0035855 megakaryocyte development 2/725 17/18722 0.139003273794408 0.330181628333577 WASF2/PIP4K2A 2 GO:0042339 keratan sulfate metabolic process 2/725 17/18722 0.139003273794408 0.330181628333577 GNS/B3GNT2 2 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/725 17/18722 0.139003273794408 0.330181628333577 CAV1/SOCS1 2 GO:0042772 DNA damage response, signal transduction resulting in transcription 2/725 17/18722 0.139003273794408 0.330181628333577 RPL26/CDKN1A 2 GO:0045198 establishment of epithelial cell apical/basal polarity 2/725 17/18722 0.139003273794408 0.330181628333577 RHOA/CDC42 2 GO:0045591 positive regulation of regulatory T cell differentiation 2/725 17/18722 0.139003273794408 0.330181628333577 CD46/SOCS1 2 GO:0045815 positive regulation of gene expression, epigenetic 2/725 17/18722 0.139003273794408 0.330181628333577 SERTAD1/SERTAD2 2 GO:0060033 anatomical structure regression 2/725 17/18722 0.139003273794408 0.330181628333577 LRP5/FLT1 2 GO:0060644 mammary gland epithelial cell differentiation 2/725 17/18722 0.139003273794408 0.330181628333577 CEBPB/ZNF703 2 GO:0070875 positive regulation of glycogen metabolic process 2/725 17/18722 0.139003273794408 0.330181628333577 IGF2/HMGB1 2 GO:0072673 lamellipodium morphogenesis 2/725 17/18722 0.139003273794408 0.330181628333577 KANK1/WASF2 2 GO:0090399 replicative senescence 2/725 17/18722 0.139003273794408 0.330181628333577 CDKN1A/SERPINE1 2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 2/725 17/18722 0.139003273794408 0.330181628333577 AKAP9/HOMER1 2 GO:0120261 regulation of heterochromatin organization 2/725 17/18722 0.139003273794408 0.330181628333577 MPHOSPH8/DNMT1 2 GO:1902358 sulfate transmembrane transport 2/725 17/18722 0.139003273794408 0.330181628333577 SLC26A2/SLC13A4 2 GO:1903358 regulation of Golgi organization 2/725 17/18722 0.139003273794408 0.330181628333577 AKAP9/PDE4DIP 2 GO:1903540 establishment of protein localization to postsynaptic membrane 2/725 17/18722 0.139003273794408 0.330181628333577 VAMP2/RAB11A 2 GO:1904355 positive regulation of telomere capping 2/725 17/18722 0.139003273794408 0.330181628333577 MAP3K4/PKIB 2 GO:0001938 positive regulation of endothelial cell proliferation 7/725 111/18722 0.139366422241356 0.330889177677485 NRP2/IGF2/PGF/PDCD6/APELA/HMGB1/CYBA 7 GO:0050818 regulation of coagulation 5/725 71/18722 0.140351698152989 0.333072452217931 CAV1/NFE2L2/C1QTNF1/SERPINB2/SERPINE1 5 GO:0002065 columnar/cuboidal epithelial cell differentiation 6/725 91/18722 0.141136464276296 0.334690492160677 SOX4/IL6ST/CEBPB/CDKN1A/HES1/SERPINE1 6 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 4/725 52/18722 0.141495704221805 0.334690492160677 PLPP3/UVRAG/KDELR2/ARF4 4 GO:0010662 regulation of striated muscle cell apoptotic process 4/725 52/18722 0.141495704221805 0.334690492160677 NFE2L2/BMP7/PPP1R10/CFLAR 4 GO:0043392 negative regulation of DNA binding 4/725 52/18722 0.141495704221805 0.334690492160677 JUN/TMSB4X/DDIT3/SRI 4 GO:0045010 actin nucleation 4/725 52/18722 0.141495704221805 0.334690492160677 IQGAP2/WASF2/ARPC3/ARF1 4 GO:0045103 intermediate filament-based process 4/725 52/18722 0.141495704221805 0.334690492160677 KRT18/DST/MACF1/PLEC 4 GO:0048260 positive regulation of receptor-mediated endocytosis 4/725 52/18722 0.141495704221805 0.334690492160677 CD63/APELA/SERPINE1/B2M 4 GO:0048562 embryonic organ morphogenesis 15/725 285/18722 0.142607388085322 0.336623399938951 FBN1/FBN2/EFEMP1/TBX3/TRIOBP/GLI3/BMP7/MIB1/RDH10/DLG1/NIPBL/TFAP2A/HES1/SETD2/ENG 15 GO:0010922 positive regulation of phosphatase activity 3/725 34/18722 0.143375403524994 0.336623399938951 SLC39A10/CALM1/PPP1R15A 3 GO:0014072 response to isoquinoline alkaloid 3/725 34/18722 0.143375403524994 0.336623399938951 FOSB/GHR/MDM2 3 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/725 34/18722 0.143375403524994 0.336623399938951 CALM1/SRI/GSTO1 3 GO:0019076 viral release from host cell 3/725 34/18722 0.143375403524994 0.336623399938951 DDB1/PPIA/ARL8B 3 GO:0019320 hexose catabolic process 3/725 34/18722 0.143375403524994 0.336623399938951 LRP5/ENO1/FUT8 3 GO:0032212 positive regulation of telomere maintenance via telomerase 3/725 34/18722 0.143375403524994 0.336623399938951 MAP3K4/PKIB/HNRNPA1 3 GO:0035308 negative regulation of protein dephosphorylation 3/725 34/18722 0.143375403524994 0.336623399938951 ROCK1/BOD1L1/PPP1R15A 3 GO:0035890 exit from host 3/725 34/18722 0.143375403524994 0.336623399938951 DDB1/PPIA/ARL8B 3 GO:0035891 exit from host cell 3/725 34/18722 0.143375403524994 0.336623399938951 DDB1/PPIA/ARL8B 3 GO:0043278 response to morphine 3/725 34/18722 0.143375403524994 0.336623399938951 FOSB/GHR/MDM2 3 GO:0048536 spleen development 3/725 34/18722 0.143375403524994 0.336623399938951 PRKDC/PBX1/BCL2 3 GO:0048741 skeletal muscle fiber development 3/725 34/18722 0.143375403524994 0.336623399938951 HOMER1/BCL2/PLEC 3 GO:0050931 pigment cell differentiation 3/725 34/18722 0.143375403524994 0.336623399938951 CD63/GLI3/BCL2 3 GO:0098751 bone cell development 3/725 34/18722 0.143375403524994 0.336623399938951 FBN1/WASF2/PIP4K2A 3 GO:2000758 positive regulation of peptidyl-lysine acetylation 3/725 34/18722 0.143375403524994 0.336623399938951 ISL1/SOX4/BRD7 3 GO:0030856 regulation of epithelial cell differentiation 9/725 154/18722 0.144013677988564 0.337965432279643 CAV1/TBX3/ROCK1/NCOA3/CEBPB/SRSF6/HES1/NUMA1/SERPINE1 9 GO:0046700 heterocycle catabolic process 22/725 445/18722 0.144783332235576 0.339614396622922 FUS/KCNQ1OT1/DDX5/UPP1/BTG2/PNP/TET2/NFE2L2/NPM1/PDE4B/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/TNRC6B/HINT1/TDG/UPF2/AGO2/YBX1 22 GO:0000271 polysaccharide biosynthetic process 5/725 72/18722 0.146352144728957 0.342268389346292 IGF2/UGP2/AGL/B3GNT2/CLTC 5 GO:0001736 establishment of planar polarity 5/725 72/18722 0.146352144728957 0.342268389346292 ZNRF3/RHOA/GPC3/CDC42/RAC1 5 GO:0007164 establishment of tissue polarity 5/725 72/18722 0.146352144728957 0.342268389346292 ZNRF3/RHOA/GPC3/CDC42/RAC1 5 GO:0030032 lamellipodium assembly 5/725 72/18722 0.146352144728957 0.342268389346292 ITGB1/WASF2/CDC42/RAC1/CAPZB 5 GO:0035567 non-canonical Wnt signaling pathway 5/725 72/18722 0.146352144728957 0.342268389346292 ZNRF3/RHOA/GPC3/CDC42/RAC1 5 GO:0043903 regulation of biological process involved in symbiotic interaction 5/725 72/18722 0.146352144728957 0.342268389346292 CAV1/ITGAV/DDB1/P4HB/LY6E 5 GO:0031058 positive regulation of histone modification 6/725 92/18722 0.14638742712621 0.342268389346292 BRD4/ISL1/BRD7/NIPBL/RTF1/DNMT1 6 GO:0048167 regulation of synaptic plasticity 11/725 198/18722 0.14718712324067 0.343979496407081 APP/NEURL1/PPP1R9A/LGMN/SYT7/ERC1/HRAS/VAMP2/RAB11A/ARF1/PAIP2 11 GO:0046434 organophosphate catabolic process 9/725 155/18722 0.148012009680716 0.345588612193251 PRDX6/UPP1/PNP/IDH1/PDE4B/GPCPD1/HINT1/TDG/PGM2 9 GO:0051147 regulation of muscle cell differentiation 9/725 155/18722 0.148012009680716 0.345588612193251 IGF2/PDCD4/BCL2/MDM2/HOPX/DNMT1/ENG/MORF4L2/YBX1 9 GO:0001541 ovarian follicle development 4/725 53/18722 0.148671540673967 0.346012874047906 BCL2/CEBPB/INHA/ZFX 4 GO:0031279 regulation of cyclase activity 4/725 53/18722 0.148671540673967 0.346012874047906 AKAP9/CALM1/NF1/TIMP2 4 GO:0033059 cellular pigmentation 4/725 53/18722 0.148671540673967 0.346012874047906 CD63/BCL2/RAB11A/RAB1A 4 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 4/725 53/18722 0.148671540673967 0.346012874047906 MET/ARRDC3/PDE4B/APELA 4 GO:0051438 regulation of ubiquitin-protein transferase activity 4/725 53/18722 0.148671540673967 0.346012874047906 ARRDC3/RPS2/SKP1/RPS20 4 GO:1903202 negative regulation of oxidative stress-induced cell death 4/725 53/18722 0.148671540673967 0.346012874047906 MET/NFE2L2/HSPB1/PPIA 4 GO:1990090 cellular response to nerve growth factor stimulus 4/725 53/18722 0.148671540673967 0.346012874047906 APP/HSPA5/BPTF/ARPC3 4 GO:0030522 intracellular receptor signaling pathway 14/725 265/18722 0.149548026292306 0.346988296983451 DDX5/NR2F2/ISL1/PARP1/RHOA/ESRRA/PUM1/HSPA1A/UFL1/NR3C1/DDX17/UBA5/RIPK2/ESRRG 14 GO:0043543 protein acylation 13/725 243/18722 0.150403631109186 0.346988296983451 ISL1/SOX4/GLUL/ZNF451/NMT1/BRD7/NCOA3/PHF20/USP22/EID1/CDYL/MBD3/MORF4L2 13 GO:0032088 negative regulation of NF-kappaB transcription factor activity 6/725 93/18722 0.151725868766898 0.346988296983451 ANXA4/TMSB4X/BMP7/UFL1/CAT/DDIT3 6 GO:0032755 positive regulation of interleukin-6 production 6/725 93/18722 0.151725868766898 0.346988296983451 APP/HSPD1/ISL1/RIPK2/HMGB1/CYBA 6 GO:0033273 response to vitamin 6/725 93/18722 0.151725868766898 0.346988296983451 ATP2B1/EGFR/DNMT3A/BMP7/MDM2/CAT 6 GO:1901019 regulation of calcium ion transmembrane transporter activity 6/725 93/18722 0.151725868766898 0.346988296983451 C4orf3/CALM1/PDE4B/SLC9A1/SRI/GSTO1 6 GO:0009166 nucleotide catabolic process 5/725 73/18722 0.152460279496116 0.346988296983451 UPP1/PNP/PDE4B/HINT1/TDG 5 GO:0032732 positive regulation of interleukin-1 production 5/725 73/18722 0.152460279496116 0.346988296983451 APP/ISL1/HSPB1/RIPK2/HMGB1 5 GO:0045739 positive regulation of DNA repair 5/725 73/18722 0.152460279496116 0.346988296983451 FUS/PRKDC/EGFR/PARP1/HMGB1 5 GO:0051145 smooth muscle cell differentiation 5/725 73/18722 0.152460279496116 0.346988296983451 TBX3/PDCD4/HES1/DNMT1/ENG 5 GO:0070988 demethylation 5/725 73/18722 0.152460279496116 0.346988296983451 TET2/KDM5A/TDG/KDM5B/USP9X 5 GO:0002076 osteoblast development 2/725 18/18722 0.152556436836467 0.346988296983451 JUND/LRP5 2 GO:0002544 chronic inflammatory response 2/725 18/18722 0.152556436836467 0.346988296983451 S100A9/GJA1 2 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 2/725 18/18722 0.152556436836467 0.346988296983451 CD46/CD55 2 GO:0006085 acetyl-CoA biosynthetic process 2/725 18/18722 0.152556436836467 0.346988296983451 ACSS1/MPC2 2 GO:0008272 sulfate transport 2/725 18/18722 0.152556436836467 0.346988296983451 SLC26A2/SLC13A4 2 GO:0009125 nucleoside monophosphate catabolic process 2/725 18/18722 0.152556436836467 0.346988296983451 UPP1/PNP 2 GO:0010985 negative regulation of lipoprotein particle clearance 2/725 18/18722 0.152556436836467 0.346988296983451 LRPAP1/MYLIP 2 GO:0021534 cell proliferation in hindbrain 2/725 18/18722 0.152556436836467 0.346988296983451 SLC6A4/RERE 2 GO:0031643 positive regulation of myelination 2/725 18/18722 0.152556436836467 0.346988296983451 DAG1/DICER1 2 GO:0031649 heat generation 2/725 18/18722 0.152556436836467 0.346988296983451 ADRB1/ARRDC3 2 GO:0033189 response to vitamin A 2/725 18/18722 0.152556436836467 0.346988296983451 DNMT3A/CAT 2 GO:0034162 toll-like receptor 9 signaling pathway 2/725 18/18722 0.152556436836467 0.346988296983451 RTN4/HMGB1 2 GO:0042693 muscle cell fate commitment 2/725 18/18722 0.152556436836467 0.346988296983451 TBX3/RBPJ 2 GO:0043217 myelin maintenance 2/725 18/18722 0.152556436836467 0.346988296983451 PLEC/EPB41L3 2 GO:0045956 positive regulation of calcium ion-dependent exocytosis 2/725 18/18722 0.152556436836467 0.346988296983451 SYT7/ARF1 2 GO:0048643 positive regulation of skeletal muscle tissue development 2/725 18/18722 0.152556436836467 0.346988296983451 IGF2/BCL2 2 GO:0051895 negative regulation of focal adhesion assembly 2/725 18/18722 0.152556436836467 0.346988296983451 LRP1/PHLDB2 2 GO:0055070 copper ion homeostasis 2/725 18/18722 0.152556436836467 0.346988296983451 APP/ARF1 2 GO:0060008 Sertoli cell differentiation 2/725 18/18722 0.152556436836467 0.346988296983451 CTSV/ATRX 2 GO:0060716 labyrinthine layer blood vessel development 2/725 18/18722 0.152556436836467 0.346988296983451 RBPJ/HES1 2 GO:0060973 cell migration involved in heart development 2/725 18/18722 0.152556436836467 0.346988296983451 BMP7/ENG 2 GO:0061484 hematopoietic stem cell homeostasis 2/725 18/18722 0.152556436836467 0.346988296983451 ADGRG1/SOX4 2 GO:0072234 metanephric nephron tubule development 2/725 18/18722 0.152556436836467 0.346988296983451 LGR4/HES1 2 GO:0080182 histone H3-K4 trimethylation 2/725 18/18722 0.152556436836467 0.346988296983451 TET2/RTF1 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/725 18/18722 0.152556436836467 0.346988296983451 LGR4/MAGED1 2 GO:0098877 neurotransmitter receptor transport to plasma membrane 2/725 18/18722 0.152556436836467 0.346988296983451 VAMP2/RAB11A 2 GO:0150118 negative regulation of cell-substrate junction organization 2/725 18/18722 0.152556436836467 0.346988296983451 LRP1/PHLDB2 2 GO:1900242 regulation of synaptic vesicle endocytosis 2/725 18/18722 0.152556436836467 0.346988296983451 CALM1/ROCK1 2 GO:1901673 regulation of mitotic spindle assembly 2/725 18/18722 0.152556436836467 0.346988296983451 HSPA1A/CCSAP 2 GO:1902074 response to salt 2/725 18/18722 0.152556436836467 0.346988296983451 HSPA5/HNRNPA1 2 GO:1902170 cellular response to reactive nitrogen species 2/725 18/18722 0.152556436836467 0.346988296983451 MTR/CFLAR 2 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 2/725 18/18722 0.152556436836467 0.346988296983451 SEMA6A/PIK3CB 2 GO:1902683 regulation of receptor localization to synapse 2/725 18/18722 0.152556436836467 0.346988296983451 DAG1/HRAS 2 GO:0006298 mismatch repair 3/725 35/18722 0.152581754581991 0.346988296983451 TDG/SETD2/HMGB1 3 GO:0031076 embryonic camera-type eye development 3/725 35/18722 0.152581754581991 0.346988296983451 BMP7/RDH10/TFAP2A 3 GO:0032205 negative regulation of telomere maintenance 3/725 35/18722 0.152581754581991 0.346988296983451 PARP1/RAD50/HNRNPA1 3 GO:0046627 negative regulation of insulin receptor signaling pathway 3/725 35/18722 0.152581754581991 0.346988296983451 KANK1/SOCS1/PIP4K2A 3 GO:0050654 chondroitin sulfate proteoglycan metabolic process 3/725 35/18722 0.152581754581991 0.346988296983451 BGN/B3GAT3/CHST12 3 GO:0098801 regulation of renal system process 3/725 35/18722 0.152581754581991 0.346988296983451 GJA1/GJA5/CYBA 3 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 3/725 35/18722 0.152581754581991 0.346988296983451 CALM1/SRI/GSTO1 3 GO:1901361 organic cyclic compound catabolic process 24/725 495/18722 0.153164800490539 0.348158015106072 FUS/KCNQ1OT1/DDX5/UPP1/BTG2/PNP/TET2/NFE2L2/NPM1/PDE4B/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/MAOA/TNRC6B/HINT1/TDG/UPF2/AGO2/CYP19A1/YBX1 24 GO:0007215 glutamate receptor signaling pathway 4/725 54/18722 0.155984167349312 0.353615270256557 APP/HOMER1/GNAQ/CPEB4 4 GO:0010524 positive regulation of calcium ion transport into cytosol 4/725 54/18722 0.155984167349312 0.353615270256557 CAV1/CALM1/SRI/GSTO1 4 GO:0035065 regulation of histone acetylation 4/725 54/18722 0.155984167349312 0.353615270256557 ISL1/ZNF451/BRD7/EID1 4 GO:0070839 metal ion export 4/725 54/18722 0.155984167349312 0.353615270256557 ATP2B1/CALM1/SLC9A1/DLG1 4 GO:0072698 protein localization to microtubule cytoskeleton 4/725 54/18722 0.155984167349312 0.353615270256557 GOLGB1/HOOK3/CEP350/NUMA1 4 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 4/725 54/18722 0.155984167349312 0.353615270256557 FOS/JUN/TEAD1/NR3C1 4 GO:0007030 Golgi organization 9/725 157/18722 0.156173040058744 0.353885176601597 AKAP9/GOLGB1/LMAN1/PDE4DIP/TRIP11/HUWE1/CDC42/TMED4/RAB1A 9 GO:0010389 regulation of G2/M transition of mitotic cell cycle 6/725 94/18722 0.157149882981038 0.355939569629527 BRD4/APP/PBX1/CDKN1A/RAB11A/CENPF 6 GO:0098876 vesicle-mediated transport to the plasma membrane 8/725 136/18722 0.157924574612611 0.357374852103271 KRT18/MACF1/GOLGA4/GOPC/EXOC1/SNX27/VAMP2/RAB11A 8 GO:1900180 regulation of protein localization to nucleus 8/725 136/18722 0.157924574612611 0.357374852103271 TFRC/MAGED1/CDH1/PARP1/GLI3/GLUL/NPM1/LATS2 8 GO:0006801 superoxide metabolic process 5/725 74/18722 0.158673015479588 0.358748222777 SOD3/EGFR/NFE2L2/BMP7/CYBA 5 GO:0120192 tight junction assembly 5/725 74/18722 0.158673015479588 0.358748222777 GJA1/ACTG1/ROCK1/CLDN4/DLG1 5 GO:0001894 tissue homeostasis 14/725 268/18722 0.158862481884689 0.359016460398345 ITGB1/TFRC/AKR1B1/LAMC1/EGFR/GJA1/NF1/JAM3/HSPB1/HOMER1/ACTG1/BCL2/RAC1/B2M 14 GO:0018393 internal peptidyl-lysine acetylation 9/725 158/18722 0.160334340500828 0.36218127094416 ISL1/ZNF451/BRD7/NCOA3/PHF20/USP22/EID1/MBD3/MORF4L2 9 GO:0015698 inorganic anion transport 10/725 180/18722 0.161441396762115 0.364357275239163 SLC26A2/CLIC3/FXYD3/GABRE/SLC13A4/ABCB1/CLDN4/CEBPB/SLC20A1/CLIC1 10 GO:0071897 DNA biosynthetic process 10/725 180/18722 0.161441396762115 0.364357275239163 MAP3K4/DUSP1/GJA1/PKIB/RAD50/USP10/HNRNPA1/CDKN1A/CENPF/NOP10 10 GO:0010762 regulation of fibroblast migration 3/725 36/18722 0.161968807623018 0.364411844581037 ITGB1/GNA12/RAC1 3 GO:0010923 negative regulation of phosphatase activity 3/725 36/18722 0.161968807623018 0.364411844581037 ROCK1/BOD1L1/PPP1R15A 3 GO:0044060 regulation of endocrine process 3/725 36/18722 0.161968807623018 0.364411844581037 GJA1/C1QTNF1/INHA 3 GO:0070670 response to interleukin-4 3/725 36/18722 0.161968807623018 0.364411844581037 RPLP0/HSPA5/RPL3 3 GO:0070873 regulation of glycogen metabolic process 3/725 36/18722 0.161968807623018 0.364411844581037 IGF2/PHLDA2/HMGB1 3 GO:0090313 regulation of protein targeting to membrane 3/725 36/18722 0.161968807623018 0.364411844581037 TCAF1/STOM/HRAS 3 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 3/725 36/18722 0.161968807623018 0.364411844581037 NMT1/HUWE1/UBE2D3 3 GO:0034754 cellular hormone metabolic process 8/725 137/18722 0.162448791132933 0.36531274703677 CYP11A1/AKR1B1/DHRS2/RDH10/HSD3B1/HSD17B1/RDH13/CYP19A1 8 GO:0032479 regulation of type I interferon production 6/725 95/18722 0.162657500505423 0.36531274703677 GAPDH/HSPD1/DHX36/SETD2/RIPK2/HMGB1 6 GO:0032606 type I interferon production 6/725 95/18722 0.162657500505423 0.36531274703677 GAPDH/HSPD1/DHX36/SETD2/RIPK2/HMGB1 6 GO:0042982 amyloid precursor protein metabolic process 6/725 95/18722 0.162657500505423 0.36531274703677 DHCR24/ITM2B/ROCK1/DLG1/AGO2/RTN4 6 GO:0003179 heart valve morphogenesis 4/725 55/18722 0.163427904971929 0.365671707637109 SOX4/ROCK1/GJA5/MDM2 4 GO:0008333 endosome to lysosome transport 4/725 55/18722 0.163427904971929 0.365671707637109 HOOK3/RHOB/SNX27/ARL8B 4 GO:0010676 positive regulation of cellular carbohydrate metabolic process 4/725 55/18722 0.163427904971929 0.365671707637109 IGF2/PMAIP1/DDB1/HMGB1 4 GO:0006720 isoprenoid metabolic process 7/725 116/18722 0.163464520494519 0.365671707637109 LRP1/LRP2/AKR1B1/EGFR/RDH10/ADH5/RDH13 7 GO:0008286 insulin receptor signaling pathway 7/725 116/18722 0.163464520494519 0.365671707637109 IGF2/KANK1/PTPRA/SOCS1/ZNF106/SLC2A8/PIP4K2A 7 GO:0034655 nucleobase-containing compound catabolic process 20/725 407/18722 0.164709187834405 0.365671707637109 FUS/KCNQ1OT1/DDX5/UPP1/BTG2/PNP/NPM1/PDE4B/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/TNRC6B/HINT1/TDG/UPF2/AGO2/YBX1 20 GO:0018209 peptidyl-serine modification 17/725 338/18722 0.164734811247654 0.365671707637109 AKAP9/CAV1/MIF/PNCK/APP/TFRC/PRKDC/EGFR/PARP1/ROCK1/LATS2/BCL2/PKN2/BGN/NEK6/RIPK2/SGK1 17 GO:0006094 gluconeogenesis 5/725 75/18722 0.164987183887281 0.365671707637109 TPI1/DDB1/SLC35B4/RANBP2/ATF3 5 GO:0006278 RNA-dependent DNA biosynthetic process 5/725 75/18722 0.164987183887281 0.365671707637109 MAP3K4/PKIB/RAD50/HNRNPA1/NOP10 5 GO:0033077 T cell differentiation in thymus 5/725 75/18722 0.164987183887281 0.365671707637109 PRKDC/RPS6/GLI3/BCL2/B2M 5 GO:0034121 regulation of toll-like receptor signaling pathway 5/725 75/18722 0.164987183887281 0.365671707637109 CAV1/LGR4/RTN4/HMGB1/CYBA 5 GO:0036465 synaptic vesicle recycling 5/725 75/18722 0.164987183887281 0.365671707637109 CALM1/ACTG1/ROCK1/SYT7/VAMP2 5 GO:0045913 positive regulation of carbohydrate metabolic process 5/725 75/18722 0.164987183887281 0.365671707637109 IGF2/APP/PMAIP1/DDB1/HMGB1 5 GO:0051453 regulation of intracellular pH 5/725 75/18722 0.164987183887281 0.365671707637109 ATP6V0E1/GRN/BCL2/SLC9A1/ATP6AP2 5 GO:0032640 tumor necrosis factor production 10/725 181/18722 0.165389926504349 0.365671707637109 MIF/APP/HSPD1/ISL1/HSPB1/DICER1/RIPK2/HMGB1/ARG2/CYBA 10 GO:0032680 regulation of tumor necrosis factor production 10/725 181/18722 0.165389926504349 0.365671707637109 MIF/APP/HSPD1/ISL1/HSPB1/DICER1/RIPK2/HMGB1/ARG2/CYBA 10 GO:0002281 macrophage activation involved in immune response 2/725 19/18722 0.16635213213872 0.365671707637109 GRN/HMGB1 2 GO:0002523 leukocyte migration involved in inflammatory response 2/725 19/18722 0.16635213213872 0.365671707637109 S100A9/JAM3 2 GO:0006007 glucose catabolic process 2/725 19/18722 0.16635213213872 0.365671707637109 LRP5/ENO1 2 GO:0006044 N-acetylglucosamine metabolic process 2/725 19/18722 0.16635213213872 0.365671707637109 EXTL2/NAGK 2 GO:0007039 protein catabolic process in the vacuole 2/725 19/18722 0.16635213213872 0.365671707637109 LRP1/LRP2 2 GO:0007530 sex determination 2/725 19/18722 0.16635213213872 0.365671707637109 MAP3K4/SF1 2 GO:0007603 phototransduction, visible light 2/725 19/18722 0.16635213213872 0.365671707637109 NMT1/GNAQ 2 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 2/725 19/18722 0.16635213213872 0.365671707637109 UPP1/TDG 2 GO:0015802 basic amino acid transport 2/725 19/18722 0.16635213213872 0.365671707637109 SLC7A6/SLC38A9 2 GO:0031290 retinal ganglion cell axon guidance 2/725 19/18722 0.16635213213872 0.365671707637109 RPL24/ISL1 2 GO:0035461 vitamin transmembrane transport 2/725 19/18722 0.16635213213872 0.365671707637109 LRP2/SLC19A3 2 GO:0036498 IRE1-mediated unfolded protein response 2/725 19/18722 0.16635213213872 0.365671707637109 HSPA5/UFL1 2 GO:0044003 modulation by symbiont of host process 2/725 19/18722 0.16635213213872 0.365671707637109 SERPINB9/DAG1 2 GO:0044827 modulation by host of viral genome replication 2/725 19/18722 0.16635213213872 0.365671707637109 HSPA8/STOM 2 GO:0045019 negative regulation of nitric oxide biosynthetic process 2/725 19/18722 0.16635213213872 0.365671707637109 DYNLL1/CAV1 2 GO:0045618 positive regulation of keratinocyte differentiation 2/725 19/18722 0.16635213213872 0.365671707637109 NCOA3/NUMA1 2 GO:0045780 positive regulation of bone resorption 2/725 19/18722 0.16635213213872 0.365671707637109 TFRC/EGFR 2 GO:0046716 muscle cell cellular homeostasis 2/725 19/18722 0.16635213213872 0.365671707637109 ALDOA/GAA 2 GO:0046794 transport of virus 2/725 19/18722 0.16635213213872 0.365671707637109 CAV1/CTSL 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/725 19/18722 0.16635213213872 0.365671707637109 RTF1/DNMT1 2 GO:0060039 pericardium development 2/725 19/18722 0.16635213213872 0.365671707637109 BMP7/SETD2 2 GO:0070262 peptidyl-serine dephosphorylation 2/725 19/18722 0.16635213213872 0.365671707637109 DUSP1/PPP1R15A 2 GO:0070989 oxidative demethylation 2/725 19/18722 0.16635213213872 0.365671707637109 TET2/TDG 2 GO:0072074 kidney mesenchyme development 2/725 19/18722 0.16635213213872 0.365671707637109 BASP1/BMP7 2 GO:0086014 atrial cardiac muscle cell action potential 2/725 19/18722 0.16635213213872 0.365671707637109 GJA1/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/725 19/18722 0.16635213213872 0.365671707637109 GJA1/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/725 19/18722 0.16635213213872 0.365671707637109 GJA1/GJA5 2 GO:1901739 regulation of myoblast fusion 2/725 19/18722 0.16635213213872 0.365671707637109 GDF15/CFLAR 2 GO:1903978 regulation of microglial cell activation 2/725 19/18722 0.16635213213872 0.365671707637109 CTSC/GRN 2 GO:1904406 negative regulation of nitric oxide metabolic process 2/725 19/18722 0.16635213213872 0.365671707637109 DYNLL1/CAV1 2 GO:2000251 positive regulation of actin cytoskeleton reorganization 2/725 19/18722 0.16635213213872 0.365671707637109 CDC42/HRAS 2 GO:2000369 regulation of clathrin-dependent endocytosis 2/725 19/18722 0.16635213213872 0.365671707637109 AAK1/PIK3CB 2 GO:2000738 positive regulation of stem cell differentiation 2/725 19/18722 0.16635213213872 0.365671707637109 DHX36/TACSTD2 2 GO:0043414 macromolecule methylation 16/725 316/18722 0.16719211925005 0.367358843727136 FOS/BRD4/KMT2C/BTG2/PARP1/ZC3H13/TET2/MPHOSPH8/DNMT3A/ATRX/ASH1L/CMTR1/RTF1/DNMT1/SETD2/MBD3 16 GO:0006475 internal protein amino acid acetylation 9/725 160/18722 0.16881480636946 0.370602968162318 ISL1/ZNF451/BRD7/NCOA3/PHF20/USP22/EID1/MBD3/MORF4L2 9 GO:0043271 negative regulation of ion transport 9/725 160/18722 0.16881480636946 0.370602968162318 C4orf3/CAV1/GABRE/CALM1/BCL2/ARL6IP5/GOPC/SRI/GSTO1 9 GO:0009260 ribonucleotide biosynthetic process 10/725 182/18722 0.169384829975505 0.371532541387206 SLC26A2/ALDOA/ACSS1/UPP1/PARP1/TMSB4X/ENO1/MPC2/AK3/RFK 10 GO:0060401 cytosolic calcium ion transport 10/725 182/18722 0.169384829975505 0.371532541387206 ATP2B1/CAV1/CALM1/BCL2/AFG3L2/ERO1A/DDIT3/SRI/GSTO1/CYBA 10 GO:0010948 negative regulation of cell cycle process 15/725 294/18722 0.16954187712387 0.371716165718382 PRKDC/DUSP1/CTDSPL/SOX4/RPL26/NPM1/BMP7/ATRX/BRD7/PPP1R10/BCL2/DLG1/MDM2/CDKN1A/CENPF 15 GO:0009101 glycoprotein biosynthetic process 16/725 317/18722 0.170195559288232 0.372517210637746 GALNT11/EXTL2/C1GALT1/TET2/ITM2B/RPN2/B3GNT2/BCL2/MAN1A2/FUT8/B3GAT3/TRIP11/CHST12/GLCE/AGO2/SERP1 16 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/725 56/18722 0.170996992693218 0.372517210637746 BTG2/DHX36/TNRC6B/AGO2 4 GO:0010658 striated muscle cell apoptotic process 4/725 56/18722 0.170996992693218 0.372517210637746 NFE2L2/BMP7/PPP1R10/CFLAR 4 GO:0030166 proteoglycan biosynthetic process 4/725 56/18722 0.170996992693218 0.372517210637746 EXTL2/B3GAT3/CHST12/GLCE 4 GO:1990089 response to nerve growth factor 4/725 56/18722 0.170996992693218 0.372517210637746 APP/HSPA5/BPTF/ARPC3 4 GO:0001937 negative regulation of endothelial cell proliferation 5/725 76/18722 0.171399541332048 0.372517210637746 CAV1/GJA1/NR2F2/NF1/FLT1 5 GO:0009123 nucleoside monophosphate metabolic process 5/725 76/18722 0.171399541332048 0.372517210637746 UPP1/PNP/DLG1/AK3/RFK 5 GO:0014823 response to activity 5/725 76/18722 0.171399541332048 0.372517210637746 HSPD1/PRKDC/COL4A2/CAT/CYBA 5 GO:0021536 diencephalon development 5/725 76/18722 0.171399541332048 0.372517210637746 NRP2/CDH1/ISL1/RBPJ/HES1 5 GO:0043536 positive regulation of blood vessel endothelial cell migration 5/725 76/18722 0.171399541332048 0.372517210637746 ANXA1/TMSB4X/NFE2L2/HSPB1/HMGB1 5 GO:0014904 myotube cell development 3/725 37/18722 0.171524002688597 0.372517210637746 HOMER1/BCL2/PLEC 3 GO:0016202 regulation of striated muscle tissue development 3/725 37/18722 0.171524002688597 0.372517210637746 IGF2/BCL2/CENPF 3 GO:0021532 neural tube patterning 3/725 37/18722 0.171524002688597 0.372517210637746 GLI3/ATP6AP2/HES1 3 GO:0043029 T cell homeostasis 3/725 37/18722 0.171524002688597 0.372517210637746 PMAIP1/RPS6/BCL2 3 GO:0048009 insulin-like growth factor receptor signaling pathway 3/725 37/18722 0.171524002688597 0.372517210637746 IGFBP3/CRIM1/GHR 3 GO:0051567 histone H3-K9 methylation 3/725 37/18722 0.171524002688597 0.372517210637746 ATRX/ASH1L/DNMT1 3 GO:0060306 regulation of membrane repolarization 3/725 37/18722 0.171524002688597 0.372517210637746 AKAP9/CAV1/GJA5 3 GO:0060428 lung epithelium development 3/725 37/18722 0.171524002688597 0.372517210637746 RBPJ/SRSF6/CDC42 3 GO:0072529 pyrimidine-containing compound catabolic process 3/725 37/18722 0.171524002688597 0.372517210637746 UPP1/TET2/TDG 3 GO:1900077 negative regulation of cellular response to insulin stimulus 3/725 37/18722 0.171524002688597 0.372517210637746 KANK1/SOCS1/PIP4K2A 3 GO:1902745 positive regulation of lamellipodium organization 3/725 37/18722 0.171524002688597 0.372517210637746 WASF2/CDC42/RAC1 3 GO:1905332 positive regulation of morphogenesis of an epithelium 3/725 37/18722 0.171524002688597 0.372517210637746 LGR4/MAGED1/GJA1 3 GO:0071346 cellular response to interferon-gamma 7/725 118/18722 0.17359434204318 0.376852128401233 GAPDH/KIF5B/RPL13A/SOCS1/ACTG1/FLNB/CDC42 7 GO:0035335 peptidyl-tyrosine dephosphorylation 6/725 97/18722 0.173915374926612 0.377225945872057 DUSP1/DUSP6/PTPRA/PTPN14/PTPN12/PTPRF 6 GO:0070167 regulation of biomineral tissue development 6/725 97/18722 0.173915374926612 0.377225945872057 ATP2B1/FBN2/BMP7/ROCK1/CEBPB/TFAP2A 6 GO:0008202 steroid metabolic process 16/725 319/18722 0.176285406753579 0.382203048260861 LRP2/APP/CYP11A1/AKR1B1/DHCR24/SF1/DHRS2/SLC27A2/PBX1/LRP5/LGMN/CAT/HSD3B1/HSD17B1/CYP19A1/FDX1 16 GO:0021953 central nervous system neuron differentiation 9/725 162/18722 0.177500505813768 0.38467296450192 NRP2/BTG2/ISL1/SOX4/GLI3/MYCBP2/C12orf57/HES1/B2M 9 GO:1901983 regulation of protein acetylation 5/725 77/18722 0.177906776936775 0.384867895960667 ISL1/SOX4/ZNF451/BRD7/EID1 5 GO:0002011 morphogenesis of an epithelial sheet 4/725 57/18722 0.178685603842617 0.384867895960667 DAG1/RHOA/BMP7/PHLDB2 4 GO:0006754 ATP biosynthetic process 4/725 57/18722 0.178685603842617 0.384867895960667 ALDOA/PARP1/TMSB4X/ENO1 4 GO:0030219 megakaryocyte differentiation 4/725 57/18722 0.178685603842617 0.384867895960667 WASF2/UBA5/RCOR1/PIP4K2A 4 GO:0050879 multicellular organismal movement 4/725 57/18722 0.178685603842617 0.384867895960667 GAA/HOMER1/C12orf57/GSTO1 4 GO:0050881 musculoskeletal movement 4/725 57/18722 0.178685603842617 0.384867895960667 GAA/HOMER1/C12orf57/GSTO1 4 GO:0050891 multicellular organismal water homeostasis 4/725 57/18722 0.178685603842617 0.384867895960667 AKR1B1/MET/CLDN4/PLEC 4 GO:0061756 leukocyte adhesion to vascular endothelial cell 4/725 57/18722 0.178685603842617 0.384867895960667 ITGB1/RHOA/NFAT5/ROCK1 4 GO:0045444 fat cell differentiation 12/725 229/18722 0.179102314891791 0.384867895960667 ADRB1/LRP5/BMP7/SOCS1/CEBPB/ARID5B/CDS1/NIPBL/ADIRF/ERO1A/HES1/DDIT3 12 GO:0043502 regulation of muscle adaptation 6/725 98/18722 0.179661410647226 0.384867895960667 DAG1/PARP1/IL6ST/ROCK1/CAMK2G/SLC9A1 6 GO:0070301 cellular response to hydrogen peroxide 6/725 98/18722 0.179661410647226 0.384867895960667 ANXA1/MET/NFE2L2/MDM2/RHOB/NET1 6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 2/725 20/18722 0.180351328432707 0.384867895960667 BRD4/BACH1 2 GO:0002115 store-operated calcium entry 2/725 20/18722 0.180351328432707 0.384867895960667 HOMER1/SARAF 2 GO:0002834 regulation of response to tumor cell 2/725 20/18722 0.180351328432707 0.384867895960667 HSPD1/HMGB1 2 GO:0002837 regulation of immune response to tumor cell 2/725 20/18722 0.180351328432707 0.384867895960667 HSPD1/HMGB1 2 GO:0003215 cardiac right ventricle morphogenesis 2/725 20/18722 0.180351328432707 0.384867895960667 ISL1/SOX4 2 GO:0006700 C21-steroid hormone biosynthetic process 2/725 20/18722 0.180351328432707 0.384867895960667 CYP11A1/AKR1B1 2 GO:0010042 response to manganese ion 2/725 20/18722 0.180351328432707 0.384867895960667 APP/HSPA5 2 GO:0032930 positive regulation of superoxide anion generation 2/725 20/18722 0.180351328432707 0.384867895960667 EGFR/CYBA 2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 2/725 20/18722 0.180351328432707 0.384867895960667 ITM2B/AGO2 2 GO:0043011 myeloid dendritic cell differentiation 2/725 20/18722 0.180351328432707 0.384867895960667 DHRS2/RBPJ 2 GO:0043555 regulation of translation in response to stress 2/725 20/18722 0.180351328432707 0.384867895960667 NPM1/PPP1R15A 2 GO:0043586 tongue development 2/725 20/18722 0.180351328432707 0.384867895960667 EGFR/GLI3 2 GO:0045844 positive regulation of striated muscle tissue development 2/725 20/18722 0.180351328432707 0.384867895960667 IGF2/BCL2 2 GO:0048636 positive regulation of muscle organ development 2/725 20/18722 0.180351328432707 0.384867895960667 IGF2/BCL2 2 GO:0051900 regulation of mitochondrial depolarization 2/725 20/18722 0.180351328432707 0.384867895960667 PARP1/BCL2 2 GO:0060252 positive regulation of glial cell proliferation 2/725 20/18722 0.180351328432707 0.384867895960667 EGFR/UFL1 2 GO:0061318 renal filtration cell differentiation 2/725 20/18722 0.180351328432707 0.384867895960667 BASP1/IQGAP1 2 GO:0071731 response to nitric oxide 2/725 20/18722 0.180351328432707 0.384867895960667 MTR/CFLAR 2 GO:0072112 glomerular visceral epithelial cell differentiation 2/725 20/18722 0.180351328432707 0.384867895960667 BASP1/IQGAP1 2 GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/725 20/18722 0.180351328432707 0.384867895960667 LRP1/HMGB1 2 GO:0097150 neuronal stem cell population maintenance 2/725 20/18722 0.180351328432707 0.384867895960667 HOOK3/HES1 2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/725 20/18722 0.180351328432707 0.384867895960667 MET/NFE2L2 2 GO:1990182 exosomal secretion 2/725 20/18722 0.180351328432707 0.384867895960667 RAB11A/SDCBP 2 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/725 20/18722 0.180351328432707 0.384867895960667 LRP1/HMGB1 2 GO:0061448 connective tissue development 13/725 252/18722 0.180710319721597 0.384867895960667 GLG1/EFEMP1/ARRDC3/GLI3/LRP5/BMP7/ESRRA/BGN/ARID5B/GHR/TRIP11/SERPINH1/CFLAR 13 GO:0016571 histone methylation 8/725 141/18722 0.181131863878575 0.384867895960667 BRD4/KMT2C/TET2/ATRX/ASH1L/RTF1/DNMT1/SETD2 8 GO:0050921 positive regulation of chemotaxis 8/725 141/18722 0.181131863878575 0.384867895960667 MET/PGF/TMSB4X/HSPB1/LGMN/HMGB1/SERPINE1/RAC1 8 GO:0000578 embryonic axis specification 3/725 38/18722 0.181234892021723 0.384867895960667 BASP1/TBX3/COBL 3 GO:0008210 estrogen metabolic process 3/725 38/18722 0.181234892021723 0.384867895960667 HSD3B1/HSD17B1/CYP19A1 3 GO:0032717 negative regulation of interleukin-8 production 3/725 38/18722 0.181234892021723 0.384867895960667 ANXA4/ANXA1/TMSB4X 3 GO:0032941 secretion by tissue 3/725 38/18722 0.181234892021723 0.384867895960667 EGFR/KCNN4/CYBA 3 GO:0042491 inner ear auditory receptor cell differentiation 3/725 38/18722 0.181234892021723 0.384867895960667 RBPJ/TRIOBP/HES1 3 GO:0042596 fear response 3/725 38/18722 0.181234892021723 0.384867895960667 ADRB1/GJA1/BCL2 3 GO:0048713 regulation of oligodendrocyte differentiation 3/725 38/18722 0.181234892021723 0.384867895960667 DAG1/NF1/HES1 3 GO:1901031 regulation of response to reactive oxygen species 3/725 38/18722 0.181234892021723 0.384867895960667 MET/NFE2L2/BMP7 3 GO:1901186 positive regulation of ERBB signaling pathway 3/725 38/18722 0.181234892021723 0.384867895960667 NEURL1/RBPJ/RTN4 3 GO:1903580 positive regulation of ATP metabolic process 3/725 38/18722 0.181234892021723 0.384867895960667 APP/TMSB4X/ENO1 3 GO:0002761 regulation of myeloid leukocyte differentiation 7/725 120/18722 0.183987415571611 0.39054950147927 FBN1/FOS/JUN/FSTL3/ESRRA/CEBPB/INHA 7 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 5/725 78/18722 0.184505519309612 0.391157874270356 PMAIP1/S100A9/HSPD1/PDCD6/CFLAR 5 GO:0035050 embryonic heart tube development 5/725 78/18722 0.184505519309612 0.391157874270356 TBX3/MIB1/APELA/HES1/ENG 5 GO:0061045 negative regulation of wound healing 5/725 78/18722 0.184505519309612 0.391157874270356 GJA1/PHLDB2/C1QTNF1/SERPINB2/SERPINE1 5 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 6/725 99/18722 0.185482614538726 0.392736580240937 TPT1/MIF/PRKDC/RPL26/BCL2/CDKN1A 6 GO:0042100 B cell proliferation 6/725 99/18722 0.185482614538726 0.392736580240937 MIF/TFRC/SLC39A10/HSPD1/BCL2/CDKN1A 6 GO:0110149 regulation of biomineralization 6/725 99/18722 0.185482614538726 0.392736580240937 ATP2B1/FBN2/BMP7/ROCK1/CEBPB/TFAP2A 6 GO:0071706 tumor necrosis factor superfamily cytokine production 10/725 186/18722 0.18581535861263 0.393112709852847 MIF/APP/HSPD1/ISL1/HSPB1/DICER1/RIPK2/HMGB1/ARG2/CYBA 10 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 10/725 186/18722 0.18581535861263 0.393112709852847 MIF/APP/HSPD1/ISL1/HSPB1/DICER1/RIPK2/HMGB1/ARG2/CYBA 10 GO:0006826 iron ion transport 4/725 58/18722 0.186487860981146 0.394042087250283 TFRC/FTH1/CLTC/B2M 4 GO:0044380 protein localization to cytoskeleton 4/725 58/18722 0.186487860981146 0.394042087250283 GOLGB1/HOOK3/CEP350/NUMA1 4 GO:1902808 positive regulation of cell cycle G1/S phase transition 4/725 58/18722 0.186487860981146 0.394042087250283 EGFR/ANXA1/ADAMTS1/MDM2 4 GO:0016050 vesicle organization 15/725 300/18722 0.188845555808486 0.398857550997174 CAV1/KIF5B/ANXA1/PDCD6/HOOK3/BCL2/SYT7/UVRAG/PIP4K2A/VAMP2/RAB11A/RAB1A/ARF1/ARL8B/SDCBP 15 GO:0072521 purine-containing compound metabolic process 20/725 416/18722 0.189002032346132 0.399021783407973 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3 20 GO:0042177 negative regulation of protein catabolic process 7/725 121/18722 0.189278861279556 0.399439861709438 EGFR/MYCBP2/ROCK1/EIF3H/TIMP3/TIMP2/SDCBP 7 GO:0061136 regulation of proteasomal protein catabolic process 10/725 187/18722 0.190032338938551 0.400863057045158 CAV1/GNA12/NFE2L2/HERPUD1/HSPA1A/UFL1/MDM2/DDA1/EIF3H/SDCBP 10 GO:0006865 amino acid transport 8/725 143/18722 0.190809870467139 0.401472240506329 ITGB1/GJA1/SLC38A1/SLC7A6/ARL6IP5/SLC38A9/MFSD12/SLC7A5 8 GO:0034763 negative regulation of transmembrane transport 8/725 143/18722 0.190809870467139 0.401472240506329 C4orf3/CAV1/CALM1/OAZ1/ARL6IP5/GOPC/SRI/GSTO1 8 GO:0002347 response to tumor cell 3/725 39/18722 0.191089172837842 0.401472240506329 HSPD1/TXNIP/HMGB1 3 GO:0010463 mesenchymal cell proliferation 3/725 39/18722 0.191089172837842 0.401472240506329 LRP5/BMP7/GPC3 3 GO:0032506 cytokinetic process 3/725 39/18722 0.191089172837842 0.401472240506329 RHOA/PLEC/ARF1 3 GO:0046326 positive regulation of glucose import 3/725 39/18722 0.191089172837842 0.401472240506329 NFE2L2/OPN3/GPC3 3 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 3/725 39/18722 0.191089172837842 0.401472240506329 CALM1/SLC9A1/GSTO1 3 GO:1901861 regulation of muscle tissue development 3/725 39/18722 0.191089172837842 0.401472240506329 IGF2/BCL2/CENPF 3 GO:0000245 spliceosomal complex assembly 5/725 79/18722 0.191192343377842 0.401472240506329 SF1/SCAF11/SRSF9/SRSF6/SNRPD2 5 GO:0006029 proteoglycan metabolic process 5/725 79/18722 0.191192343377842 0.401472240506329 EXTL2/BGN/B3GAT3/CHST12/GLCE 5 GO:0032272 negative regulation of protein polymerization 5/725 79/18722 0.191192343377842 0.401472240506329 KANK1/TRIOBP/TMSB4X/PFN1/CAPZB 5 GO:0032768 regulation of monooxygenase activity 4/725 59/18722 0.194397850256098 0.403347076952662 CAV1/EGFR/CALM1/PIK3CB 4 GO:0035306 positive regulation of dephosphorylation 4/725 59/18722 0.194397850256098 0.403347076952662 SLC39A10/CALM1/PPP1R15A/PPIA 4 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4/725 59/18722 0.194397850256098 0.403347076952662 PGF/PDCD6/HSPB1/FLT1 4 GO:0051353 positive regulation of oxidoreductase activity 4/725 59/18722 0.194397850256098 0.403347076952662 CALM1/RFK/PIK3CB/CYBA 4 GO:2001258 negative regulation of cation channel activity 4/725 59/18722 0.194397850256098 0.403347076952662 CAV1/CALM1/SRI/GSTO1 4 GO:0000002 mitochondrial genome maintenance 2/725 21/18722 0.194517646145397 0.403347076952662 PARP1/SLC25A36 2 GO:0002689 negative regulation of leukocyte chemotaxis 2/725 21/18722 0.194517646145397 0.403347076952662 MIF/DUSP1 2 GO:0003177 pulmonary valve development 2/725 21/18722 0.194517646145397 0.403347076952662 RBPJ/GJA5 2 GO:0006067 ethanol metabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 ACSS1/ADH5 2 GO:0006244 pyrimidine nucleotide catabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 UPP1/TDG 2 GO:0006450 regulation of translational fidelity 2/725 21/18722 0.194517646145397 0.403347076952662 IARS2/RPS5 2 GO:0030449 regulation of complement activation 2/725 21/18722 0.194517646145397 0.403347076952662 CD46/CD55 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 SLC26A2/TPST2 2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 2/725 21/18722 0.194517646145397 0.403347076952662 WASF2/ARF1 2 GO:0042454 ribonucleoside catabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 UPP1/PNP 2 GO:0044766 multi-organism transport 2/725 21/18722 0.194517646145397 0.403347076952662 CAV1/CTSL 2 GO:0046641 positive regulation of alpha-beta T cell proliferation 2/725 21/18722 0.194517646145397 0.403347076952662 CD55/RIPK2 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 SLC26A2/TPST2 2 GO:0072170 metanephric tubule development 2/725 21/18722 0.194517646145397 0.403347076952662 LGR4/HES1 2 GO:0072243 metanephric nephron epithelium development 2/725 21/18722 0.194517646145397 0.403347076952662 LGR4/HES1 2 GO:0072311 glomerular epithelial cell differentiation 2/725 21/18722 0.194517646145397 0.403347076952662 BASP1/IQGAP1 2 GO:0097734 extracellular exosome biogenesis 2/725 21/18722 0.194517646145397 0.403347076952662 RAB11A/SDCBP 2 GO:0150105 protein localization to cell-cell junction 2/725 21/18722 0.194517646145397 0.403347076952662 DLG5/ACTG1 2 GO:1901863 positive regulation of muscle tissue development 2/725 21/18722 0.194517646145397 0.403347076952662 IGF2/BCL2 2 GO:1902579 multi-organism localization 2/725 21/18722 0.194517646145397 0.403347076952662 CAV1/CTSL 2 GO:1902644 tertiary alcohol metabolic process 2/725 21/18722 0.194517646145397 0.403347076952662 CYP11A1/AKR1B1 2 GO:2000291 regulation of myoblast proliferation 2/725 21/18722 0.194517646145397 0.403347076952662 MALAT1/ZNF609 2 GO:2001014 regulation of skeletal muscle cell differentiation 2/725 21/18722 0.194517646145397 0.403347076952662 DDX5/DDX17 2 GO:0031109 microtubule polymerization or depolymerization 7/725 122/18722 0.194631475680847 0.403347076952662 AKAP9/CLIP1/MET/HSPA1A/NUMA1/CCSAP/RAC1 7 GO:0051208 sequestering of calcium ion 7/725 122/18722 0.194631475680847 0.403347076952662 CALM1/HSP90B1/ERO1A/DDIT3/SRI/GSTO1/CYBA 7 GO:0051928 positive regulation of calcium ion transport 7/725 122/18722 0.194631475680847 0.403347076952662 ATP2B1/CAV1/CALM1/HOMER1/SLC9A1/SRI/GSTO1 7 GO:1990266 neutrophil migration 7/725 122/18722 0.194631475680847 0.403347076952662 CSF3R/S100A9/JAM3/PDE4B/CD99/RAC1/PPIA 7 GO:0009117 nucleotide metabolic process 23/725 489/18722 0.195709003932247 0.404959244739592 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/UPP1/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3/TDG/RFK 23 GO:0007612 learning 8/725 144/18722 0.195728970134544 0.404959244739592 ITGB1/FOS/APP/JUN/BTG2/NF1/LGMN/ARF4 8 GO:0010821 regulation of mitochondrion organization 8/725 144/18722 0.195728970134544 0.404959244739592 TFRC/PMAIP1/PISD/BNIP3L/NMT1/HSPA1A/HUWE1/CHCHD10 8 GO:0033135 regulation of peptidyl-serine phosphorylation 8/725 144/18722 0.195728970134544 0.404959244739592 AKAP9/CAV1/MIF/APP/TFRC/EGFR/BCL2/RIPK2 8 GO:0006476 protein deacetylation 6/725 101/18722 0.197341564219277 0.40812908569054 TBL1X/NIPBL/KDM5A/HOPX/RCOR1/MORF4L2 6 GO:0051303 establishment of chromosome localization 5/725 80/18722 0.197963777069998 0.40924893391836 DYNC1H1/KPNB1/NUMA1/RAB11A/CENPF 5 GO:0019439 aromatic compound catabolic process 22/725 467/18722 0.200040226607797 0.413043262487065 FUS/KCNQ1OT1/DDX5/UPP1/BTG2/PNP/TET2/NPM1/PDE4B/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/MAOA/TNRC6B/HINT1/TDG/UPF2/AGO2/YBX1 22 GO:0030168 platelet activation 7/725 123/18722 0.200043639653925 0.413043262487065 IL6ST/HSPB1/ACTG1/C1QTNF1/CLIC1/PIK3CB/PPIA 7 GO:0050852 T cell receptor signaling pathway 7/725 123/18722 0.200043639653925 0.413043262487065 KCNN4/EZR/PDE4B/HRAS/RIPK2/PHPT1/CBLB 7 GO:0009394 2'-deoxyribonucleotide metabolic process 3/725 40/18722 0.201074716527356 0.413991770136949 UPP1/PNP/TDG 3 GO:0032094 response to food 3/725 40/18722 0.201074716527356 0.413991770136949 NUCB2/PLEC/GHR 3 GO:0046365 monosaccharide catabolic process 3/725 40/18722 0.201074716527356 0.413991770136949 LRP5/ENO1/FUT8 3 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 3/725 40/18722 0.201074716527356 0.413991770136949 CALM1/SRI/GSTO1 3 GO:0072210 metanephric nephron development 3/725 40/18722 0.201074716527356 0.413991770136949 LGR4/IRX2/HES1 3 GO:0097352 autophagosome maturation 3/725 40/18722 0.201074716527356 0.413991770136949 CALM1/UVRAG/MAP1LC3B 3 GO:2000781 positive regulation of double-strand break repair 3/725 40/18722 0.201074716527356 0.413991770136949 FUS/PRKDC/PARP1 3 GO:0051851 modulation by host of symbiont process 4/725 60/18722 0.202409635058247 0.416448130075939 JUN/HSPA8/STOM/CFL1 4 GO:0045165 cell fate commitment 13/725 258/18722 0.202432075854629 0.416448130075939 ITGB1/PRKDC/TBX3/NR2F2/ISL1/RBPJ/GLI3/CTSL/RHOA/BCL2/RTF1/CDC42/HES1 13 GO:0046390 ribose phosphate biosynthetic process 10/725 190/18722 0.202934218940249 0.417311787346095 SLC26A2/ALDOA/ACSS1/UPP1/PARP1/TMSB4X/ENO1/MPC2/AK3/RFK 10 GO:0010522 regulation of calcium ion transport into cytosol 6/725 102/18722 0.203374728559233 0.417878597108534 CAV1/CALM1/BCL2/SRI/GSTO1/CYBA 6 GO:0034308 primary alcohol metabolic process 6/725 102/18722 0.203374728559233 0.417878597108534 ACSS1/CYP11A1/AKR1B1/RDH10/ADH5/RDH13 6 GO:0030641 regulation of cellular pH 5/725 81/18722 0.204816307837017 0.420499742578306 ATP6V0E1/GRN/BCL2/SLC9A1/ATP6AP2 5 GO:0051149 positive regulation of muscle cell differentiation 5/725 81/18722 0.204816307837017 0.420499742578306 BCL2/MDM2/HOPX/ENG/MORF4L2 5 GO:0048813 dendrite morphogenesis 8/725 146/18722 0.205721312557147 0.42218677463651 ITGB1/CUX1/PPP1R9A/DHX36/CFL1/RERE/BTBD3/CDC42 8 GO:0051051 negative regulation of transport 22/725 470/18722 0.20829604087985 0.424927516134239 C4orf3/CAV1/ITGAV/GJA1/GABRE/ANXA1/LMAN1/CALM1/PPP1R9A/LRPAP1/OAZ1/BCL2/RAB11FIP1/ARL6IP5/GOPC/INHA/ERP29/HMGB1/SRI/RAC1/SDCBP/GSTO1 22 GO:0006907 pinocytosis 2/725 22/18722 0.20881721102592 0.424927516134239 CAV1/CDC42 2 GO:0007398 ectoderm development 2/725 22/18722 0.20881721102592 0.424927516134239 TPT1/ITGA6 2 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 2/725 22/18722 0.20881721102592 0.424927516134239 CALM1/GSTO1 2 GO:0014821 phasic smooth muscle contraction 2/725 22/18722 0.20881721102592 0.424927516134239 TBX3/DLG1 2 GO:0019400 alditol metabolic process 2/725 22/18722 0.20881721102592 0.424927516134239 TPI1/AKR1B1 2 GO:0031281 positive regulation of cyclase activity 2/725 22/18722 0.20881721102592 0.424927516134239 NF1/TIMP2 2 GO:0032402 melanosome transport 2/725 22/18722 0.20881721102592 0.424927516134239 RAB11A/RAB1A 2 GO:0032700 negative regulation of interleukin-17 production 2/725 22/18722 0.20881721102592 0.424927516134239 DDIT3/ARG2 2 GO:0035089 establishment of apical/basal cell polarity 2/725 22/18722 0.20881721102592 0.424927516134239 RHOA/CDC42 2 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 2/725 22/18722 0.20881721102592 0.424927516134239 ANXA1/HMGB1 2 GO:0045624 positive regulation of T-helper cell differentiation 2/725 22/18722 0.20881721102592 0.424927516134239 ANXA1/RIPK2 2 GO:0051151 negative regulation of smooth muscle cell differentiation 2/725 22/18722 0.20881721102592 0.424927516134239 PDCD4/DNMT1 2 GO:0060713 labyrinthine layer morphogenesis 2/725 22/18722 0.20881721102592 0.424927516134239 SPINT1/BMP7 2 GO:0060965 negative regulation of gene silencing by miRNA 2/725 22/18722 0.20881721102592 0.424927516134239 NEAT1/KCNQ1OT1 2 GO:0072574 hepatocyte proliferation 2/725 22/18722 0.20881721102592 0.424927516134239 CEBPB/CFLAR 2 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 2/725 22/18722 0.20881721102592 0.424927516134239 CEBPB/CFLAR 2 GO:1901032 negative regulation of response to reactive oxygen species 2/725 22/18722 0.20881721102592 0.424927516134239 MET/NFE2L2 2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 2/725 22/18722 0.20881721102592 0.424927516134239 RBPJ/NFE2L2 2 GO:2000114 regulation of establishment of cell polarity 2/725 22/18722 0.20881721102592 0.424927516134239 KANK1/ROCK1 2 GO:2000773 negative regulation of cellular senescence 2/725 22/18722 0.20881721102592 0.424927516134239 PRKDC/YBX1 2 GO:0031214 biomineral tissue development 9/725 169/18722 0.209417156161626 0.425580451014487 ATP2B1/FBN2/LGR4/BMP7/GPC3/ROCK1/CEBPB/SLC20A1/TFAP2A 9 GO:0030593 neutrophil chemotaxis 6/725 103/18722 0.209473905164953 0.425580451014487 CSF3R/S100A9/JAM3/PDE4B/RAC1/PPIA 6 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 6/725 103/18722 0.209473905164953 0.425580451014487 CAV1/AKR1B1/CSH1/SOCS1/GHR/HES1 6 GO:0050773 regulation of dendrite development 6/725 103/18722 0.209473905164953 0.425580451014487 CUX1/RHOA/BMP7/COBL/DHX36/IQGAP1 6 GO:0060997 dendritic spine morphogenesis 4/725 61/18722 0.21051726898564 0.426821915779724 PPP1R9A/DHX36/CFL1/CDC42 4 GO:0051053 negative regulation of DNA metabolic process 7/725 125/18722 0.211039989567354 0.426821915779724 DUSP1/GJA1/PARP1/RAD50/HNRNPA1/CDKN1A/SUB1 7 GO:0071621 granulocyte chemotaxis 7/725 125/18722 0.211039989567354 0.426821915779724 CSF3R/S100A9/ANXA1/JAM3/PDE4B/RAC1/PPIA 7 GO:0009167 purine ribonucleoside monophosphate metabolic process 3/725 41/18722 0.211179594550315 0.426821915779724 PNP/DLG1/AK3 3 GO:0031062 positive regulation of histone methylation 3/725 41/18722 0.211179594550315 0.426821915779724 BRD4/RTF1/DNMT1 3 GO:0032733 positive regulation of interleukin-10 production 3/725 41/18722 0.211179594550315 0.426821915779724 CD46/HSPD1/HMGB1 3 GO:0048634 regulation of muscle organ development 3/725 41/18722 0.211179594550315 0.426821915779724 IGF2/BCL2/CENPF 3 GO:0060612 adipose tissue development 3/725 41/18722 0.211179594550315 0.426821915779724 ARRDC3/LRP5/ARID5B 3 GO:0070296 sarcoplasmic reticulum calcium ion transport 3/725 41/18722 0.211179594550315 0.426821915779724 CALM1/SRI/GSTO1 3 GO:1900371 regulation of purine nucleotide biosynthetic process 3/725 41/18722 0.211179594550315 0.426821915779724 PARP1/TMSB4X/ENO1 3 GO:1901385 regulation of voltage-gated calcium channel activity 3/725 41/18722 0.211179594550315 0.426821915779724 CALM1/PDE4B/SRI 3 GO:1902622 regulation of neutrophil migration 3/725 41/18722 0.211179594550315 0.426821915779724 JAM3/CD99/RAC1 3 GO:1905314 semi-lunar valve development 3/725 41/18722 0.211179594550315 0.426821915779724 RBPJ/ROCK1/GJA5 3 GO:0050000 chromosome localization 5/725 82/18722 0.211746389004236 0.427626472455167 DYNC1H1/KPNB1/NUMA1/RAB11A/CENPF 5 GO:0072527 pyrimidine-containing compound metabolic process 5/725 82/18722 0.211746389004236 0.427626472455167 SLC19A3/UPP1/TET2/AK3/TDG 5 GO:0006892 post-Golgi vesicle-mediated transport 6/725 104/18722 0.21563671883015 0.435136356588387 KRT18/MACF1/GOLGA4/GOPC/EXOC1/VAMP2 6 GO:0060419 heart growth 6/725 104/18722 0.21563671883015 0.435136356588387 BASP1/TGFBR3/GJA1/DUSP6/RBPJ/DUSP9 6 GO:0044272 sulfur compound biosynthetic process 8/725 148/18722 0.215910829701362 0.435169779624734 SLC26A2/ACSS1/NFE2L2/MTR/B3GNT2/CHST12/GLCE/MPC2 8 GO:0050905 neuromuscular process 8/725 148/18722 0.215910829701362 0.435169779624734 APP/TMEM150C/GAA/MYCBP2/HOMER1/UBA5/C12orf57/GSTO1 8 GO:0097530 granulocyte migration 8/725 148/18722 0.215910829701362 0.435169779624734 CSF3R/S100A9/ANXA1/JAM3/PDE4B/CD99/RAC1/PPIA 8 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 10/725 193/18722 0.21619641026881 0.435572179512162 IGF2/MIF/NEURL1/ISL1/CSH1/IL6ST/GHR/IQGAP1/HES1/RIPK2 10 GO:0006753 nucleoside phosphate metabolic process 23/725 497/18722 0.217294667516737 0.437610913644156 GAPDH/SLC26A2/LDHA/ALDOA/TPI1/APP/ACSS1/PKM/UPP1/PARP1/PNP/TMSB4X/CROT/RHOA/ENO1/PDE4B/TPST2/DLG1/HINT1/MPC2/AK3/TDG/RFK 23 GO:0032615 interleukin-12 production 4/725 62/18722 0.21871480812046 0.43862579529502 HSPD1/ISL1/RIPK2/HMGB1 4 GO:0032655 regulation of interleukin-12 production 4/725 62/18722 0.21871480812046 0.43862579529502 HSPD1/ISL1/RIPK2/HMGB1 4 GO:0048002 antigen processing and presentation of peptide antigen 4/725 62/18722 0.21871480812046 0.43862579529502 CTSL/CTSV/LGMN/B2M 4 GO:0048488 synaptic vesicle endocytosis 4/725 62/18722 0.21871480812046 0.43862579529502 CALM1/ACTG1/ROCK1/VAMP2 4 GO:0048663 neuron fate commitment 4/725 62/18722 0.21871480812046 0.43862579529502 ISL1/RBPJ/GLI3/CDC42 4 GO:0060113 inner ear receptor cell differentiation 4/725 62/18722 0.21871480812046 0.43862579529502 RBPJ/TRIOBP/TRIP11/HES1 4 GO:0140238 presynaptic endocytosis 4/725 62/18722 0.21871480812046 0.43862579529502 CALM1/ACTG1/ROCK1/VAMP2 4 GO:0043367 CD4-positive, alpha-beta T cell differentiation 5/725 83/18722 0.218750445947092 0.43862579529502 ANXA1/CTSL/SOCS1/RIPK2/HMGB1 5 GO:0050672 negative regulation of lymphocyte proliferation 5/725 83/18722 0.218750445947092 0.43862579529502 DLG5/CEBPB/DLG1/ARG2/CBLB 5 GO:0051899 membrane depolarization 5/725 83/18722 0.218750445947092 0.43862579529502 CAV1/JUN/PARP1/GJA5/BCL2 5 GO:1901292 nucleoside phosphate catabolic process 5/725 83/18722 0.218750445947092 0.43862579529502 UPP1/PNP/PDE4B/HINT1/TDG 5 GO:0110148 biomineralization 9/725 171/18722 0.218938729043609 0.438829742001602 ATP2B1/FBN2/LGR4/BMP7/GPC3/ROCK1/CEBPB/SLC20A1/TFAP2A 9 GO:0007520 myoblast fusion 3/725 42/18722 0.221392101266981 0.440613182663626 ADAM12/GDF15/CFLAR 3 GO:0009154 purine ribonucleotide catabolic process 3/725 42/18722 0.221392101266981 0.440613182663626 PNP/PDE4B/HINT1 3 GO:0021879 forebrain neuron differentiation 3/725 42/18722 0.221392101266981 0.440613182663626 NRP2/HES1/B2M 3 GO:0030808 regulation of nucleotide biosynthetic process 3/725 42/18722 0.221392101266981 0.440613182663626 PARP1/TMSB4X/ENO1 3 GO:0032467 positive regulation of cytokinesis 3/725 42/18722 0.221392101266981 0.440613182663626 RHOA/PKN2/CDC42 3 GO:0032689 negative regulation of interferon-gamma production 3/725 42/18722 0.221392101266981 0.440613182663626 INHA/DDIT3/HMGB1 3 GO:0046688 response to copper ion 3/725 42/18722 0.221392101266981 0.440613182663626 APP/SOD3/NFE2L2 3 GO:0051602 response to electrical stimulus 3/725 42/18722 0.221392101266981 0.440613182663626 AKAP9/BTG2/SLC9A1 3 GO:0070085 glycosylation 12/725 240/18722 0.221712467899004 0.440613182663626 GALNT11/EXTL2/C1GALT1/TET2/RPN2/NANS/B3GNT2/MAN1A2/FUT8/B3GAT3/TRIP11/SERP1 12 GO:0044270 cellular nitrogen compound catabolic process 21/725 451/18722 0.221791024867129 0.440613182663626 FUS/KCNQ1OT1/DDX5/UPP1/BTG2/PNP/TET2/NPM1/PDE4B/DHX36/DICER1/ROCK1/PUM1/LARP1/HSPA1A/TNRC6B/HINT1/TDG/UPF2/AGO2/YBX1 21 GO:0009162 deoxyribonucleoside monophosphate metabolic process 2/725 23/18722 0.223218515107554 0.440613182663626 UPP1/PNP 2 GO:0018279 protein N-linked glycosylation via asparagine 2/725 23/18722 0.223218515107554 0.440613182663626 RPN2/FUT8 2 GO:0030194 positive regulation of blood coagulation 2/725 23/18722 0.223218515107554 0.440613182663626 NFE2L2/SERPINE1 2 GO:0031338 regulation of vesicle fusion 2/725 23/18722 0.223218515107554 0.440613182663626 KIF5B/ANXA1 2 GO:0032401 establishment of melanosome localization 2/725 23/18722 0.223218515107554 0.440613182663626 RAB11A/RAB1A 2 GO:0034105 positive regulation of tissue remodeling 2/725 23/18722 0.223218515107554 0.440613182663626 ROCK1/TMBIM1 2 GO:0035994 response to muscle stretch 2/725 23/18722 0.223218515107554 0.440613182663626 FOS/SLC9A1 2 GO:0036303 lymph vessel morphogenesis 2/725 23/18722 0.223218515107554 0.440613182663626 SVEP1/PTPN14 2 GO:0040019 positive regulation of embryonic development 2/725 23/18722 0.223218515107554 0.440613182663626 CFL1/AMOT 2 GO:0042438 melanin biosynthetic process 2/725 23/18722 0.223218515107554 0.440613182663626 OPN3/MFSD12 2 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 2/725 23/18722 0.223218515107554 0.440613182663626 CTSL/BCL2 2 GO:0045662 negative regulation of myoblast differentiation 2/725 23/18722 0.223218515107554 0.440613182663626 TBX3/DDIT3 2 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 2/725 23/18722 0.223218515107554 0.440613182663626 B3GAT3/CHST12 2 GO:0051349 positive regulation of lyase activity 2/725 23/18722 0.223218515107554 0.440613182663626 NF1/TIMP2 2 GO:0051457 maintenance of protein location in nucleus 2/725 23/18722 0.223218515107554 0.440613182663626 SKP1/CHCHD10 2 GO:0051882 mitochondrial depolarization 2/725 23/18722 0.223218515107554 0.440613182663626 PARP1/BCL2 2 GO:0051904 pigment granule transport 2/725 23/18722 0.223218515107554 0.440613182663626 RAB11A/RAB1A 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/725 23/18722 0.223218515107554 0.440613182663626 AKAP9/GJA5 2 GO:0060353 regulation of cell adhesion molecule production 2/725 23/18722 0.223218515107554 0.440613182663626 CAV1/COLEC12 2 GO:0060575 intestinal epithelial cell differentiation 2/725 23/18722 0.223218515107554 0.440613182663626 IL6ST/CDKN1A 2 GO:0071514 genetic imprinting 2/725 23/18722 0.223218515107554 0.440613182663626 IGF2/DNMT3A 2 GO:0071636 positive regulation of transforming growth factor beta production 2/725 23/18722 0.223218515107554 0.440613182663626 CD46/ATP6AP2 2 GO:0072576 liver morphogenesis 2/725 23/18722 0.223218515107554 0.440613182663626 CEBPB/CFLAR 2 GO:0140112 extracellular vesicle biogenesis 2/725 23/18722 0.223218515107554 0.440613182663626 RAB11A/SDCBP 2 GO:1900048 positive regulation of hemostasis 2/725 23/18722 0.223218515107554 0.440613182663626 NFE2L2/SERPINE1 2 GO:1900273 positive regulation of long-term synaptic potentiation 2/725 23/18722 0.223218515107554 0.440613182663626 APP/LGMN 2 GO:1902410 mitotic cytokinetic process 2/725 23/18722 0.223218515107554 0.440613182663626 RHOA/ARF1 2 GO:1904666 regulation of ubiquitin protein ligase activity 2/725 23/18722 0.223218515107554 0.440613182663626 SKP1/RPS20 2 GO:2000810 regulation of bicellular tight junction assembly 2/725 23/18722 0.223218515107554 0.440613182663626 GJA1/ROCK1 2 GO:0062012 regulation of small molecule metabolic process 16/725 334/18722 0.225287934651506 0.444524928278896 CAV1/IGF2/APP/PMAIP1/DDB1/ANXA1/PARP1/PHLDA2/TMSB4X/ENO1/RDH10/SLC35B4/RANBP2/C1QTNF1/NCOA2/HMGB1 16 GO:0006405 RNA export from nucleus 5/725 84/18722 0.225824882084333 0.444718852869263 NPM1/PABPN1/HNRNPA1/UPF2/SETD2 5 GO:0006835 dicarboxylic acid transport 5/725 84/18722 0.225824882084333 0.444718852869263 SLC26A2/ITGB1/LRP2/GJA1/ARL6IP5 5 GO:0006970 response to osmotic stress 5/725 84/18722 0.225824882084333 0.444718852869263 AKR1B1/EGFR/EFHD1/ABCB1/NFAT5 5 GO:0032370 positive regulation of lipid transport 5/725 84/18722 0.225824882084333 0.444718852869263 CAV1/LRP1/DBI/C1QTNF1/CYP19A1 5 GO:0032945 negative regulation of mononuclear cell proliferation 5/725 84/18722 0.225824882084333 0.444718852869263 DLG5/CEBPB/DLG1/ARG2/CBLB 5 GO:0001756 somitogenesis 4/725 63/18722 0.226996322627564 0.446678710946865 PRKDC/RBPJ/COBL/MIB1 4 GO:2000242 negative regulation of reproductive process 4/725 63/18722 0.226996322627564 0.446678710946865 DUSP1/GJA1/BMP7/SERPINF1 4 GO:2000278 regulation of DNA biosynthetic process 6/725 106/18722 0.228143621559661 0.448762133366675 MAP3K4/DUSP1/GJA1/PKIB/HNRNPA1/CDKN1A 6 GO:0043535 regulation of blood vessel endothelial cell migration 8/725 151/18722 0.231542132637491 0.453997380388754 ANXA1/TMSB4X/NFE2L2/RHOA/NF1/HSPB1/CSNK2B/HMGB1 8 GO:0001504 neurotransmitter uptake 3/725 43/18722 0.231700773932868 0.453997380388754 ITGB1/SLC38A1/SLC6A4 3 GO:0001709 cell fate determination 3/725 43/18722 0.231700773932868 0.453997380388754 ISL1/CDC42/HES1 3 GO:0006284 base-excision repair 3/725 43/18722 0.231700773932868 0.453997380388754 HUWE1/TDG/HMGB1 3 GO:0014014 negative regulation of gliogenesis 3/725 43/18722 0.231700773932868 0.453997380388754 NF1/DICER1/HES1 3 GO:0016266 O-glycan processing 3/725 43/18722 0.231700773932868 0.453997380388754 GALNT11/C1GALT1/B3GNT2 3 GO:0032365 intracellular lipid transport 3/725 43/18722 0.231700773932868 0.453997380388754 SYT7/PIP4K2A/ARL8B 3 GO:0045981 positive regulation of nucleotide metabolic process 3/725 43/18722 0.231700773932868 0.453997380388754 APP/TMSB4X/ENO1 3 GO:0140353 lipid export from cell 3/725 43/18722 0.231700773932868 0.453997380388754 C1QTNF1/KDM5B/CYP19A1 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/725 43/18722 0.231700773932868 0.453997380388754 APP/TMSB4X/ENO1 3 GO:0009142 nucleoside triphosphate biosynthetic process 5/725 85/18722 0.232966084683455 0.455771934874733 ALDOA/PARP1/TMSB4X/ENO1/AK3 5 GO:0055072 iron ion homeostasis 5/725 85/18722 0.232966084683455 0.455771934874733 TFRC/FTH1/SRI/B2M/ATP6V1G1 5 GO:0072384 organelle transport along microtubule 5/725 85/18722 0.232966084683455 0.455771934874733 ARMCX3/KIF5B/DYNC1H1/CDC42/RAB1A 5 GO:2000779 regulation of double-strand break repair 5/725 85/18722 0.232966084683455 0.455771934874733 FUS/PRKDC/PARP1/DEK/SETD2 5 GO:0007584 response to nutrient 9/725 174/18722 0.233526475090718 0.456692014751099 LDHA/ATP2B1/AGL/EGFR/DNMT3A/SLC6A4/BMP7/MDM2/CAT 9 GO:0021761 limbic system development 6/725 107/18722 0.234482835180667 0.458032174000308 NRP2/KIF5B/TBX3/BTG2/GLI3/HSD3B1 6 GO:0051341 regulation of oxidoreductase activity 6/725 107/18722 0.234482835180667 0.458032174000308 CAV1/EGFR/CALM1/RFK/PIK3CB/CYBA 6 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 6/725 107/18722 0.234482835180667 0.458032174000308 CAV1/NFE2L2/HERPUD1/HSPA1A/MDM2/DDA1 6 GO:0017156 calcium-ion regulated exocytosis 4/725 64/18722 0.23535590768517 0.458853498483125 SYT7/VAMP2/ARF1/ARL8B 4 GO:0030104 water homeostasis 4/725 64/18722 0.23535590768517 0.458853498483125 AKR1B1/MET/CLDN4/PLEC 4 GO:0046854 phosphatidylinositol phosphate biosynthetic process 4/725 64/18722 0.23535590768517 0.458853498483125 SOCS1/TMEM150A/PIP4K2A/PIK3CB 4 GO:0050771 negative regulation of axonogenesis 4/725 64/18722 0.23535590768517 0.458853498483125 SEMA6D/SEMA6A/SEMA4C/RTN4 4 GO:1903018 regulation of glycoprotein metabolic process 4/725 64/18722 0.23535590768517 0.458853498483125 ITM2B/BCL2/AGO2/RAB1A 4 GO:0008643 carbohydrate transport 8/725 152/18722 0.236839770084994 0.459345097571173 NFE2L2/EZR/OPN3/GPC3/SLC35B4/MFSD12/SLC2A8/SLC2A12 8 GO:0001702 gastrulation with mouth forming second 2/725 24/18722 0.237692284657563 0.459345097571173 LRP5/AMOT 2 GO:0002021 response to dietary excess 2/725 24/18722 0.237692284657563 0.459345097571173 ADRB1/GDF15 2 GO:0002726 positive regulation of T cell cytokine production 2/725 24/18722 0.237692284657563 0.459345097571173 CD55/B2M 2 GO:0003181 atrioventricular valve morphogenesis 2/725 24/18722 0.237692284657563 0.459345097571173 SOX4/MDM2 2 GO:0006817 phosphate ion transport 2/725 24/18722 0.237692284657563 0.459345097571173 CEBPB/SLC20A1 2 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 2/725 24/18722 0.237692284657563 0.459345097571173 UPP1/TDG 2 GO:0010226 response to lithium ion 2/725 24/18722 0.237692284657563 0.459345097571173 CDH1/NFE2L2 2 GO:0018196 peptidyl-asparagine modification 2/725 24/18722 0.237692284657563 0.459345097571173 RPN2/FUT8 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/725 24/18722 0.237692284657563 0.459345097571173 TMSB4X/ENO1 2 GO:0032928 regulation of superoxide anion generation 2/725 24/18722 0.237692284657563 0.459345097571173 EGFR/CYBA 2 GO:0048641 regulation of skeletal muscle tissue development 2/725 24/18722 0.237692284657563 0.459345097571173 IGF2/BCL2 2 GO:0050820 positive regulation of coagulation 2/725 24/18722 0.237692284657563 0.459345097571173 NFE2L2/SERPINE1 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/725 24/18722 0.237692284657563 0.459345097571173 CALM1/PIK3CB 2 GO:0051570 regulation of histone H3-K9 methylation 2/725 24/18722 0.237692284657563 0.459345097571173 ATRX/DNMT1 2 GO:0051905 establishment of pigment granule localization 2/725 24/18722 0.237692284657563 0.459345097571173 RAB11A/RAB1A 2 GO:0060149 negative regulation of posttranscriptional gene silencing 2/725 24/18722 0.237692284657563 0.459345097571173 NEAT1/KCNQ1OT1 2 GO:0060561 apoptotic process involved in morphogenesis 2/725 24/18722 0.237692284657563 0.459345097571173 LRP5/BMP7 2 GO:0060571 morphogenesis of an epithelial fold 2/725 24/18722 0.237692284657563 0.459345097571173 BMP7/RDH10 2 GO:0060967 negative regulation of gene silencing by RNA 2/725 24/18722 0.237692284657563 0.459345097571173 NEAT1/KCNQ1OT1 2 GO:0061162 establishment of monopolar cell polarity 2/725 24/18722 0.237692284657563 0.459345097571173 RHOA/CDC42 2 GO:0072010 glomerular epithelium development 2/725 24/18722 0.237692284657563 0.459345097571173 BASP1/IQGAP1 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/725 24/18722 0.237692284657563 0.459345097571173 TMSB4X/ENO1 2 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 11/725 221/18722 0.238873176826491 0.46145127032526 CAV1/CTSC/GNA12/NFE2L2/HERPUD1/HSPA1A/UFL1/MDM2/DDA1/EIF3H/SDCBP 11 GO:0006282 regulation of DNA repair 7/725 130/18722 0.239454287548395 0.462045597100424 FUS/PRKDC/EGFR/PARP1/DEK/SETD2/HMGB1 7 GO:0006352 DNA-templated transcription, initiation 7/725 130/18722 0.239454287548395 0.462045597100424 JUN/TFAM/ZNF451/DHX36/BDP1/HMGB1/SUB1 7 GO:0043467 regulation of generation of precursor metabolites and energy 7/725 130/18722 0.239454287548395 0.462045597100424 IGF2/APP/PHLDA2/RHOA/OPN3/HMGB1/CHCHD2 7 GO:0018105 peptidyl-serine phosphorylation 15/725 315/18722 0.241357195556768 0.464311980574404 AKAP9/CAV1/MIF/PNCK/APP/TFRC/PRKDC/EGFR/ROCK1/LATS2/BCL2/PKN2/NEK6/RIPK2/SGK1 15 GO:0005978 glycogen biosynthetic process 3/725 44/18722 0.242094410072628 0.464311980574404 IGF2/UGP2/AGL 3 GO:0006775 fat-soluble vitamin metabolic process 3/725 44/18722 0.242094410072628 0.464311980574404 LRP2/CYP11A1/LGMN 3 GO:0008542 visual learning 3/725 44/18722 0.242094410072628 0.464311980574404 ITGB1/APP/NF1 3 GO:0009126 purine nucleoside monophosphate metabolic process 3/725 44/18722 0.242094410072628 0.464311980574404 PNP/DLG1/AK3 3 GO:0009250 glucan biosynthetic process 3/725 44/18722 0.242094410072628 0.464311980574404 IGF2/UGP2/AGL 3 GO:0009262 deoxyribonucleotide metabolic process 3/725 44/18722 0.242094410072628 0.464311980574404 UPP1/PNP/TDG 3 GO:0021517 ventral spinal cord development 3/725 44/18722 0.242094410072628 0.464311980574404 ISL1/SOX4/GLI3 3 GO:0030521 androgen receptor signaling pathway 3/725 44/18722 0.242094410072628 0.464311980574404 DDX5/RHOA/DDX17 3 GO:0032620 interleukin-17 production 3/725 44/18722 0.242094410072628 0.464311980574404 DDIT3/SLC7A5/ARG2 3 GO:0032660 regulation of interleukin-17 production 3/725 44/18722 0.242094410072628 0.464311980574404 DDIT3/SLC7A5/ARG2 3 GO:0045124 regulation of bone resorption 3/725 44/18722 0.242094410072628 0.464311980574404 TFRC/EGFR/NF1 3 GO:0051150 regulation of smooth muscle cell differentiation 3/725 44/18722 0.242094410072628 0.464311980574404 PDCD4/DNMT1/ENG 3 GO:0060324 face development 3/725 44/18722 0.242094410072628 0.464311980574404 ANKRD11/ARID5B/NIPBL 3 GO:0089718 amino acid import across plasma membrane 3/725 44/18722 0.242094410072628 0.464311980574404 ITGB1/ARL6IP5/SLC7A5 3 GO:0150076 neuroinflammatory response 3/725 44/18722 0.242094410072628 0.464311980574404 ITGB1/CTSC/GRN 3 GO:0002720 positive regulation of cytokine production involved in immune response 4/725 65/18722 0.243787693759802 0.466676669059077 DHX36/CD55/SLC7A5/B2M 4 GO:0033692 cellular polysaccharide biosynthetic process 4/725 65/18722 0.243787693759802 0.466676669059077 IGF2/UGP2/AGL/B3GNT2 4 GO:0043489 RNA stabilization 4/725 65/18722 0.243787693759802 0.466676669059077 FUS/DHX36/LARP1/YBX1 4 GO:0045453 bone resorption 4/725 65/18722 0.243787693759802 0.466676669059077 TFRC/EGFR/NF1/RAC1 4 GO:0070613 regulation of protein processing 4/725 65/18722 0.243787693759802 0.466676669059077 GLG1/ENO1/MDM2/SERPINE1 4 GO:0002456 T cell mediated immunity 6/725 109/18722 0.247320459543522 0.472643951785324 CD46/HSPD1/CTSC/CD55/HMGB1/B2M 6 GO:0032410 negative regulation of transporter activity 6/725 109/18722 0.247320459543522 0.472643951785324 C4orf3/CAV1/CALM1/GOPC/SRI/GSTO1 6 GO:0032259 methylation 17/725 364/18722 0.247383655597604 0.472643951785324 FOS/BRD4/KMT2C/BTG2/PARP1/ZC3H13/TET2/MPHOSPH8/DNMT3A/ATRX/ASH1L/MTR/CMTR1/RTF1/DNMT1/SETD2/MBD3 17 GO:1900182 positive regulation of protein localization to nucleus 5/725 87/18722 0.247434291064879 0.472643951785324 TFRC/CDH1/PARP1/GLI3/NPM1 5 GO:1903578 regulation of ATP metabolic process 5/725 87/18722 0.247434291064879 0.472643951785324 APP/PARP1/TMSB4X/RHOA/ENO1 5 GO:0007605 sensory perception of sound 8/725 154/18722 0.247557642925634 0.472643951785324 LRP2/TRIOBP/TBL1X/SLC52A3/USP53/NIPBL/TFAP2A/DDIT3 8 GO:0050770 regulation of axonogenesis 8/725 154/18722 0.247557642925634 0.472643951785324 LRP1/SEMA6D/SEMA6A/MACF1/GOLGA4/SEMA4C/RAB11A/RTN4 8 GO:0010842 retina layer formation 2/725 25/18722 0.252211354783347 0.474337604985705 TFAP2A/RDH13 2 GO:0021846 cell proliferation in forebrain 2/725 25/18722 0.252211354783347 0.474337604985705 GLI3/HOOK3 2 GO:0030318 melanocyte differentiation 2/725 25/18722 0.252211354783347 0.474337604985705 GLI3/BCL2 2 GO:0031579 membrane raft organization 2/725 25/18722 0.252211354783347 0.474337604985705 CAV1/DLG1 2 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 2/725 25/18722 0.252211354783347 0.474337604985705 CD55/SASH1 2 GO:0032400 melanosome localization 2/725 25/18722 0.252211354783347 0.474337604985705 RAB11A/RAB1A 2 GO:0032753 positive regulation of interleukin-4 production 2/725 25/18722 0.252211354783347 0.474337604985705 CEBPB/SLC7A5 2 GO:0032878 regulation of establishment or maintenance of cell polarity 2/725 25/18722 0.252211354783347 0.474337604985705 KANK1/ROCK1 2 GO:0032925 regulation of activin receptor signaling pathway 2/725 25/18722 0.252211354783347 0.474337604985705 FSTL3/CSNK2B 2 GO:0034389 lipid droplet organization 2/725 25/18722 0.252211354783347 0.474337604985705 CDS1/PPIA 2 GO:0035902 response to immobilization stress 2/725 25/18722 0.252211354783347 0.474337604985705 FOS/MDM2 2 GO:0042730 fibrinolysis 2/725 25/18722 0.252211354783347 0.474337604985705 SERPINB2/SERPINE1 2 GO:0044550 secondary metabolite biosynthetic process 2/725 25/18722 0.252211354783347 0.474337604985705 OPN3/MFSD12 2 GO:0046039 GTP metabolic process 2/725 25/18722 0.252211354783347 0.474337604985705 RHOA/AK3 2 GO:0048596 embryonic camera-type eye morphogenesis 2/725 25/18722 0.252211354783347 0.474337604985705 BMP7/TFAP2A 2 GO:0051450 myoblast proliferation 2/725 25/18722 0.252211354783347 0.474337604985705 MALAT1/ZNF609 2 GO:0060074 synapse maturation 2/725 25/18722 0.252211354783347 0.474337604985705 NEURL1/PFN1 2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 2/725 25/18722 0.252211354783347 0.474337604985705 DHX36/SUB1 2 GO:0061339 establishment or maintenance of monopolar cell polarity 2/725 25/18722 0.252211354783347 0.474337604985705 RHOA/CDC42 2 GO:0062009 secondary palate development 2/725 25/18722 0.252211354783347 0.474337604985705 TGFBR3/DLG1 2 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 2/725 25/18722 0.252211354783347 0.474337604985705 HSPA1A/RIPK2 2 GO:0072207 metanephric epithelium development 2/725 25/18722 0.252211354783347 0.474337604985705 LGR4/HES1 2 GO:0090330 regulation of platelet aggregation 2/725 25/18722 0.252211354783347 0.474337604985705 IL6ST/C1QTNF1 2 GO:0090382 phagosome maturation 2/725 25/18722 0.252211354783347 0.474337604985705 SYT7/ARL8B 2 GO:1900078 positive regulation of cellular response to insulin stimulus 2/725 25/18722 0.252211354783347 0.474337604985705 IGF2/ESRRA 2 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 2/725 25/18722 0.252211354783347 0.474337604985705 EGFR/DDX5 2 GO:1903901 negative regulation of viral life cycle 2/725 25/18722 0.252211354783347 0.474337604985705 LY6E/PPIA 2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 2/725 25/18722 0.252211354783347 0.474337604985705 RHOA/NFAT5 2 GO:1905564 positive regulation of vascular endothelial cell proliferation 2/725 25/18722 0.252211354783347 0.474337604985705 IGF2/HMGB1 2 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 4/725 66/18722 0.252285856239031 0.474337604985705 TFRC/HSPD1/PRKDC/HMGB1 4 GO:0006303 double-strand break repair via nonhomologous end joining 4/725 66/18722 0.252285856239031 0.474337604985705 PRKDC/DEK/UVRAG/HMGB1 4 GO:0016444 somatic cell DNA recombination 4/725 66/18722 0.252285856239031 0.474337604985705 TFRC/HSPD1/PRKDC/HMGB1 4 GO:0046626 regulation of insulin receptor signaling pathway 4/725 66/18722 0.252285856239031 0.474337604985705 IGF2/KANK1/SOCS1/PIP4K2A 4 GO:0072678 T cell migration 4/725 66/18722 0.252285856239031 0.474337604985705 APP/RHOA/PLEC/CD99 4 GO:0003254 regulation of membrane depolarization 3/725 45/18722 0.252562082433698 0.474337604985705 PARP1/GJA5/BCL2 3 GO:0035305 negative regulation of dephosphorylation 3/725 45/18722 0.252562082433698 0.474337604985705 ROCK1/BOD1L1/PPP1R15A 3 GO:0044088 regulation of vacuole organization 3/725 45/18722 0.252562082433698 0.474337604985705 GRN/RALB/PIP4K2A 3 GO:0045933 positive regulation of muscle contraction 3/725 45/18722 0.252562082433698 0.474337604985705 RHOA/ENO1/GSTO1 3 GO:0048546 digestive tract morphogenesis 3/725 45/18722 0.252562082433698 0.474337604985705 GLI3/BCL2/NIPBL 3 GO:0060119 inner ear receptor cell development 3/725 45/18722 0.252562082433698 0.474337604985705 TRIOBP/TRIP11/HES1 3 GO:0060421 positive regulation of heart growth 3/725 45/18722 0.252562082433698 0.474337604985705 BASP1/TGFBR3/RBPJ 3 GO:0085029 extracellular matrix assembly 3/725 45/18722 0.252562082433698 0.474337604985705 DAG1/LAMB1/PHLDB2 3 GO:1901985 positive regulation of protein acetylation 3/725 45/18722 0.252562082433698 0.474337604985705 ISL1/SOX4/BRD7 3 GO:2000273 positive regulation of signaling receptor activity 3/725 45/18722 0.252562082433698 0.474337604985705 ITGB1/NEURL1/NCOA3 3 GO:0006473 protein acetylation 10/725 201/18722 0.253154726056307 0.475274557918304 ISL1/SOX4/ZNF451/BRD7/NCOA3/PHF20/USP22/EID1/MBD3/MORF4L2 10 GO:0006939 smooth muscle contraction 6/725 110/18722 0.253813896997998 0.475807190785079 ATP2B1/CAV1/TBX3/RHOA/ROCK1/DLG1 6 GO:0007088 regulation of mitotic nuclear division 6/725 110/18722 0.253813896997998 0.475807190785079 IGF2/DUSP1/LRP5/BMP7/CDC42/CENPF 6 GO:0018958 phenol-containing compound metabolic process 6/725 110/18722 0.253813896997998 0.475807190785079 AKR1B1/OPN3/BCL2/MAOA/MFSD12/LY6E 6 GO:1905954 positive regulation of lipid localization 6/725 110/18722 0.253813896997998 0.475807190785079 PLIN2/CAV1/LRP1/DBI/C1QTNF1/CYP19A1 6 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 7/725 133/18722 0.257065142174696 0.481723920770252 CAV1/CTSC/NFE2L2/HERPUD1/HSPA1A/MDM2/DDA1 7 GO:0001764 neuron migration 8/725 156/18722 0.258429672554245 0.484101999326486 NRP2/ADGRG1/SEMA6A/NR2F2/NIPBL/ZNF609/USP9X/RAC1 8 GO:1901988 negative regulation of cell cycle phase transition 12/725 249/18722 0.259366353608368 0.485677150513786 PRKDC/DUSP1/CTDSPL/SOX4/RPL26/BRD7/PPP1R10/BCL2/DLG1/MDM2/CDKN1A/CENPF 12 GO:0006879 cellular iron ion homeostasis 4/725 67/18722 0.260844624436749 0.487904576114348 TFRC/FTH1/SRI/ATP6V1G1 4 GO:0009583 detection of light stimulus 4/725 67/18722 0.260844624436749 0.487904576114348 OPN3/NMT1/GNAQ/CDS1 4 GO:0042490 mechanoreceptor differentiation 4/725 67/18722 0.260844624436749 0.487904576114348 RBPJ/TRIOBP/TRIP11/HES1 4 GO:0006486 protein glycosylation 11/725 226/18722 0.261224137079504 0.488254111672569 GALNT11/EXTL2/C1GALT1/TET2/RPN2/B3GNT2/MAN1A2/FUT8/B3GAT3/TRIP11/SERP1 11 GO:0043413 macromolecule glycosylation 11/725 226/18722 0.261224137079504 0.488254111672569 GALNT11/EXTL2/C1GALT1/TET2/RPN2/B3GNT2/MAN1A2/FUT8/B3GAT3/TRIP11/SERP1 11 GO:0006195 purine nucleotide catabolic process 3/725 46/18722 0.263093151707978 0.490481495405569 PNP/PDE4B/HINT1 3 GO:0010828 positive regulation of glucose transmembrane transport 3/725 46/18722 0.263093151707978 0.490481495405569 NFE2L2/OPN3/GPC3 3 GO:0031018 endocrine pancreas development 3/725 46/18722 0.263093151707978 0.490481495405569 ANXA1/SOX4/HES1 3 GO:0031057 negative regulation of histone modification 3/725 46/18722 0.263093151707978 0.490481495405569 ZNF451/KDM5A/DNMT1 3 GO:0031648 protein destabilization 3/725 46/18722 0.263093151707978 0.490481495405569 PRKDC/MDM2/MYLIP 3 GO:0033047 regulation of mitotic sister chromatid segregation 3/725 46/18722 0.263093151707978 0.490481495405569 DUSP1/NUMA1/CENPF 3 GO:0034198 cellular response to amino acid starvation 3/725 46/18722 0.263093151707978 0.490481495405569 TFEB/CDKN1A/ATF3 3 GO:0070646 protein modification by small protein removal 8/725 157/18722 0.263919961547292 0.491842016574715 USP27X/USP10/USP22/USP53/HINT1/USP48/USP9X/UCHL3 8 GO:0002092 positive regulation of receptor internalization 2/725 26/18722 0.266750550378498 0.492038650141782 CD63/APELA 2 GO:0002418 immune response to tumor cell 2/725 26/18722 0.266750550378498 0.492038650141782 HSPD1/HMGB1 2 GO:0009164 nucleoside catabolic process 2/725 26/18722 0.266750550378498 0.492038650141782 UPP1/PNP 2 GO:0010875 positive regulation of cholesterol efflux 2/725 26/18722 0.266750550378498 0.492038650141782 CAV1/LRP1 2 GO:0014829 vascular associated smooth muscle contraction 2/725 26/18722 0.266750550378498 0.492038650141782 ATP2B1/RHOA 2 GO:0018027 peptidyl-lysine dimethylation 2/725 26/18722 0.266750550378498 0.492038650141782 ASH1L/SETD2 2 GO:0021680 cerebellar Purkinje cell layer development 2/725 26/18722 0.266750550378498 0.492038650141782 HSPA5/RERE 2 GO:0021952 central nervous system projection neuron axonogenesis 2/725 26/18722 0.266750550378498 0.492038650141782 MYCBP2/C12orf57 2 GO:0034063 stress granule assembly 2/725 26/18722 0.266750550378498 0.492038650141782 PRRC2C/DYNC1H1 2 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 2/725 26/18722 0.266750550378498 0.492038650141782 HSPA1A/RIPK2 2 GO:0042634 regulation of hair cycle 2/725 26/18722 0.266750550378498 0.492038650141782 NIPBL/NUMA1 2 GO:0043094 cellular metabolic compound salvage 2/725 26/18722 0.266750550378498 0.492038650141782 UPP1/PNP 2 GO:0043501 skeletal muscle adaptation 2/725 26/18722 0.266750550378498 0.492038650141782 CAMK2G/CFLAR 2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 2/725 26/18722 0.266750550378498 0.492038650141782 SLC39A10/KCNN4 2 GO:0051016 barbed-end actin filament capping 2/725 26/18722 0.266750550378498 0.492038650141782 TRIOBP/CAPZB 2 GO:0051350 negative regulation of lyase activity 2/725 26/18722 0.266750550378498 0.492038650141782 AKAP9/PHPT1 2 GO:0051875 pigment granule localization 2/725 26/18722 0.266750550378498 0.492038650141782 RAB11A/RAB1A 2 GO:0060544 regulation of necroptotic process 2/725 26/18722 0.266750550378498 0.492038650141782 CAV1/CFLAR 2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 2/725 26/18722 0.266750550378498 0.492038650141782 EGFR/DDX5 2 GO:0072273 metanephric nephron morphogenesis 2/725 26/18722 0.266750550378498 0.492038650141782 LGR4/HES1 2 GO:0097066 response to thyroid hormone 2/725 26/18722 0.266750550378498 0.492038650141782 AKR1B1/CTSL 2 GO:0099637 neurotransmitter receptor transport 2/725 26/18722 0.266750550378498 0.492038650141782 VAMP2/RAB11A 2 GO:1901071 glucosamine-containing compound metabolic process 2/725 26/18722 0.266750550378498 0.492038650141782 EXTL2/NAGK 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/725 26/18722 0.266750550378498 0.492038650141782 ZNRF3/GPC3 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/725 26/18722 0.266750550378498 0.492038650141782 ANXA1/PIK3CB 2 GO:0000956 nuclear-transcribed mRNA catabolic process 6/725 112/18722 0.266937519804675 0.492038650141782 DDX5/BTG2/DHX36/TNRC6B/UPF2/AGO2 6 GO:0002821 positive regulation of adaptive immune response 6/725 112/18722 0.266937519804675 0.492038650141782 TFRC/HSPD1/IL6ST/CD55/RIPK2/B2M 6 GO:0009141 nucleoside triphosphate metabolic process 6/725 112/18722 0.266937519804675 0.492038650141782 ALDOA/PARP1/TMSB4X/RHOA/ENO1/AK3 6 GO:0010633 negative regulation of epithelial cell migration 6/725 112/18722 0.266937519804675 0.492038650141782 NR2F2/RHOA/CSNK2B/SERPINF1/TACSTD2/HMGB1 6 GO:0035601 protein deacylation 6/725 112/18722 0.266937519804675 0.492038650141782 TBL1X/NIPBL/KDM5A/HOPX/RCOR1/MORF4L2 6 GO:0007059 chromosome segregation 16/725 346/18722 0.268235403524918 0.494251276069724 DUSP1/DYNC1H1/ATRX/PUM1/NR3C1/NIPBL/KPNB1/CDC42/STAG1/UVRAG/NEK6/NUMA1/USP9X/RAB11A/CENPF/ARL8B 16 GO:0006479 protein methylation 9/725 181/18722 0.268838956195269 0.495003512151769 BRD4/KMT2C/BTG2/TET2/ATRX/ASH1L/RTF1/DNMT1/SETD2 9 GO:0008213 protein alkylation 9/725 181/18722 0.268838956195269 0.495003512151769 BRD4/KMT2C/BTG2/TET2/ATRX/ASH1L/RTF1/DNMT1/SETD2 9 GO:0007585 respiratory gaseous exchange by respiratory system 4/725 68/18722 0.269458289986768 0.495227353567331 GAA/MAN1A2/FUT8/ADH5 4 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 4/725 68/18722 0.269458289986768 0.495227353567331 ALDOA/PARP1/TMSB4X/ENO1 4 GO:0042698 ovulation cycle 4/725 68/18722 0.269458289986768 0.495227353567331 EGFR/HSPA5/ADAMTS1/SERPINF1 4 GO:0051148 negative regulation of muscle cell differentiation 4/725 68/18722 0.269458289986768 0.495227353567331 IGF2/PDCD4/DNMT1/YBX1 4 GO:0048477 oogenesis 5/725 90/18722 0.269546709112698 0.495227353567331 LGR5/RPS6/DIAPH2/BCL2/ZFX 5 GO:0070664 negative regulation of leukocyte proliferation 5/725 90/18722 0.269546709112698 0.495227353567331 DLG5/CEBPB/DLG1/ARG2/CBLB 5 GO:0034470 ncRNA processing 18/725 395/18722 0.272052525782966 0.499650091736905 RPS21/RPL14/PRKDC/RPS6/RPS16/RPS8/RPS25/RPL26/RPS19/RPL10A/DICER1/DDX17/RPL7A/RPL7/RPL27/AGO2/SNU13/NOP10 18 GO:0001774 microglial cell activation 3/725 47/18722 0.273677277197813 0.50045819556844 APP/CTSC/GRN 3 GO:0010712 regulation of collagen metabolic process 3/725 47/18722 0.273677277197813 0.50045819556844 ITGB1/SUCO/ENG 3 GO:0035315 hair cell differentiation 3/725 47/18722 0.273677277197813 0.50045819556844 RBPJ/TRIOBP/HES1 3 GO:0035850 epithelial cell differentiation involved in kidney development 3/725 47/18722 0.273677277197813 0.50045819556844 BASP1/IQGAP1/MTSS1 3 GO:0045747 positive regulation of Notch signaling pathway 3/725 47/18722 0.273677277197813 0.50045819556844 AAK1/IL6ST/HES1 3 GO:0045911 positive regulation of DNA recombination 3/725 47/18722 0.273677277197813 0.50045819556844 TFRC/FUS/PARP1 3 GO:0047496 vesicle transport along microtubule 3/725 47/18722 0.273677277197813 0.50045819556844 KIF5B/DYNC1H1/RAB1A 3 GO:0048512 circadian behavior 3/725 47/18722 0.273677277197813 0.50045819556844 ADRB1/ZFHX3/NCOA2 3 GO:0061001 regulation of dendritic spine morphogenesis 3/725 47/18722 0.273677277197813 0.50045819556844 PPP1R9A/DHX36/CFL1 3 GO:0072583 clathrin-dependent endocytosis 3/725 47/18722 0.273677277197813 0.50045819556844 AAK1/CLTC/PIK3CB 3 GO:0101023 vascular endothelial cell proliferation 3/725 47/18722 0.273677277197813 0.50045819556844 IGF2/HMGB1/FLT1 3 GO:1905562 regulation of vascular endothelial cell proliferation 3/725 47/18722 0.273677277197813 0.50045819556844 IGF2/HMGB1/FLT1 3 GO:0006354 DNA-templated transcription, elongation 5/725 91/18722 0.277012421021791 0.505644926956953 BRD4/SERTAD1/RTF1/SERTAD2/SETD2 5 GO:0006885 regulation of pH 5/725 91/18722 0.277012421021791 0.505644926956953 ATP6V0E1/GRN/BCL2/SLC9A1/ATP6AP2 5 GO:0042147 retrograde transport, endosome to Golgi 5/725 91/18722 0.277012421021791 0.505644926956953 SPAG9/CLTC/ERC1/TMEM87A/RHOBTB3 5 GO:0051983 regulation of chromosome segregation 5/725 91/18722 0.277012421021791 0.505644926956953 DUSP1/PUM1/NEK6/NUMA1/CENPF 5 GO:0055006 cardiac cell development 5/725 91/18722 0.277012421021791 0.505644926956953 TGFBR3/TBX3/ISL1/PDCD4/PLEC 5 GO:0003143 embryonic heart tube morphogenesis 4/725 69/18722 0.278121214641391 0.50693866847077 TBX3/MIB1/HES1/ENG 4 GO:0009145 purine nucleoside triphosphate biosynthetic process 4/725 69/18722 0.278121214641391 0.50693866847077 ALDOA/PARP1/TMSB4X/ENO1 4 GO:0010611 regulation of cardiac muscle hypertrophy 4/725 69/18722 0.278121214641391 0.50693866847077 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:0031060 regulation of histone methylation 4/725 69/18722 0.278121214641391 0.50693866847077 BRD4/ATRX/RTF1/DNMT1 4 GO:0002819 regulation of adaptive immune response 9/725 183/18722 0.279215666253963 0.508502724350403 CD46/TFRC/HSPD1/ANXA1/IL6ST/CD55/RIPK2/HMGB1/B2M 9 GO:1901800 positive regulation of proteasomal protein catabolic process 6/725 114/18722 0.280226749230818 0.508502724350403 CAV1/NFE2L2/HERPUD1/HSPA1A/MDM2/DDA1 6 GO:1903008 organelle disassembly 6/725 114/18722 0.280226749230818 0.508502724350403 KIF5B/BNIP3L/UFL1/UBA5/HUWE1/MAP1LC3B 6 GO:1904892 regulation of receptor signaling pathway via STAT 6/725 114/18722 0.280226749230818 0.508502724350403 CAV1/AKR1B1/CSH1/SOCS1/GHR/HES1 6 GO:0060402 calcium ion transport into cytosol 8/725 160/18722 0.280590728578971 0.508502724350403 CAV1/CALM1/BCL2/ERO1A/DDIT3/SRI/GSTO1/CYBA 8 GO:0002825 regulation of T-helper 1 type immune response 2/725 27/18722 0.281286573106831 0.508502724350403 ANXA1/RIPK2 2 GO:0009651 response to salt stress 2/725 27/18722 0.281286573106831 0.508502724350403 AKR1B1/EFHD1 2 GO:0010561 negative regulation of glycoprotein biosynthetic process 2/725 27/18722 0.281286573106831 0.508502724350403 ITM2B/AGO2 2 GO:0015813 L-glutamate transmembrane transport 2/725 27/18722 0.281286573106831 0.508502724350403 ITGB1/ARL6IP5 2 GO:0016556 mRNA modification 2/725 27/18722 0.281286573106831 0.508502724350403 ZC3H13/CMTR1 2 GO:0032967 positive regulation of collagen biosynthetic process 2/725 27/18722 0.281286573106831 0.508502724350403 SUCO/ENG 2 GO:0034698 response to gonadotropin 2/725 27/18722 0.281286573106831 0.508502724350403 TGFBR3/CTSV 2 GO:0035116 embryonic hindlimb morphogenesis 2/725 27/18722 0.281286573106831 0.508502724350403 TBX3/GPC3 2 GO:0035235 ionotropic glutamate receptor signaling pathway 2/725 27/18722 0.281286573106831 0.508502724350403 APP/CPEB4 2 GO:0036037 CD8-positive, alpha-beta T cell activation 2/725 27/18722 0.281286573106831 0.508502724350403 SOCS1/BCL2 2 GO:0042104 positive regulation of activated T cell proliferation 2/725 27/18722 0.281286573106831 0.508502724350403 IGF2/HMGB1 2 GO:0045606 positive regulation of epidermal cell differentiation 2/725 27/18722 0.281286573106831 0.508502724350403 NCOA3/NUMA1 2 GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/725 27/18722 0.281286573106831 0.508502724350403 GDF15/CFLAR 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/725 27/18722 0.281286573106831 0.508502724350403 AKAP9/GJA5 2 GO:1902883 negative regulation of response to oxidative stress 2/725 27/18722 0.281286573106831 0.508502724350403 MET/NFE2L2 2 GO:1903205 regulation of hydrogen peroxide-induced cell death 2/725 27/18722 0.281286573106831 0.508502724350403 MET/NFE2L2 2 GO:1903319 positive regulation of protein maturation 2/725 27/18722 0.281286573106831 0.508502724350403 SOX4/ENO1 2 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 2/725 27/18722 0.281286573106831 0.508502724350403 PARP1/HNRNPA1 2 GO:0006111 regulation of gluconeogenesis 3/725 48/18722 0.28430442559132 0.513043479288859 DDB1/SLC35B4/RANBP2 3 GO:0010569 regulation of double-strand break repair via homologous recombination 3/725 48/18722 0.28430442559132 0.513043479288859 FUS/PARP1/SETD2 3 GO:0032527 protein exit from endoplasmic reticulum 3/725 48/18722 0.28430442559132 0.513043479288859 HSP90B1/HERPUD1/SEC61B 3 GO:0042908 xenobiotic transport 3/725 48/18722 0.28430442559132 0.513043479288859 GJA1/ABCB1/SLC7A5 3 GO:0045839 negative regulation of mitotic nuclear division 3/725 48/18722 0.28430442559132 0.513043479288859 DUSP1/BMP7/CENPF 3 GO:0001708 cell fate specification 5/725 92/18722 0.284519604579009 0.513249066053735 ITGB1/TBX3/ISL1/RBPJ/GLI3 5 GO:0045123 cellular extravasation 4/725 70/18722 0.286827837492344 0.516672805899006 ITGB1/JAM3/ROCK1/CD99 4 GO:0070830 bicellular tight junction assembly 4/725 70/18722 0.286827837492344 0.516672805899006 GJA1/ROCK1/CLDN4/DLG1 4 GO:0000077 DNA damage checkpoint signaling 6/725 115/18722 0.286927194437897 0.516672805899006 PRKDC/SOX4/RPL26/PPP1R10/MDM2/CDKN1A 6 GO:0051209 release of sequestered calcium ion into cytosol 6/725 115/18722 0.286927194437897 0.516672805899006 CALM1/ERO1A/DDIT3/SRI/GSTO1/CYBA 6 GO:0071675 regulation of mononuclear cell migration 6/725 115/18722 0.286927194437897 0.516672805899006 APP/DUSP1/RHOA/LGMN/HMGB1/SERPINE1 6 GO:0043433 negative regulation of DNA-binding transcription factor activity 9/725 185/18722 0.289703241383279 0.521486410004204 ANXA4/TMSB4X/BMP7/UFL1/CAT/PURA/HES1/DDIT3/SRI 9 GO:0007589 body fluid secretion 5/725 93/18722 0.292064703204697 0.523899205232997 CAV1/EGFR/KCNN4/NEURL1/CYBA 5 GO:0071222 cellular response to lipopolysaccharide 10/725 209/18722 0.292068368607087 0.523899205232997 PDCD4/RHOA/PDE4B/CEBPB/PABPN1/CD55/SASH1/RIPK2/HMGB1/SERPINE1 10 GO:0016579 protein deubiquitination 7/725 139/18722 0.293321239083825 0.523899205232997 USP27X/USP10/USP22/USP53/USP48/USP9X/UCHL3 7 GO:0045598 regulation of fat cell differentiation 7/725 139/18722 0.293321239083825 0.523899205232997 LRP5/BMP7/CEBPB/CDS1/ADIRF/HES1/DDIT3 7 GO:0033559 unsaturated fatty acid metabolic process 6/725 116/18722 0.293661522107536 0.523899205232997 CYP2J2/MIF/AKR1B1/ANXA1/SCD/GPX4 6 GO:0051283 negative regulation of sequestering of calcium ion 6/725 116/18722 0.293661522107536 0.523899205232997 CALM1/ERO1A/DDIT3/SRI/GSTO1/CYBA 6 GO:0098732 macromolecule deacylation 6/725 116/18722 0.293661522107536 0.523899205232997 TBL1X/NIPBL/KDM5A/HOPX/RCOR1/MORF4L2 6 GO:0051480 regulation of cytosolic calcium ion concentration 16/725 353/18722 0.29455319713895 0.523899205232997 ATP2B1/CAV1/LRP1/ITGAV/GJA1/CALM1/BCL2/GTF2I/CD55/C1QTNF1/ERO1A/DDIT3/HMGB1/SRI/GSTO1/CYBA 16 GO:0002762 negative regulation of myeloid leukocyte differentiation 3/725 49/18722 0.294964878001428 0.523899205232997 FBN1/FSTL3/INHA 3 GO:0006376 mRNA splice site selection 3/725 49/18722 0.294964878001428 0.523899205232997 SF1/SRSF9/SRSF6 3 GO:0006692 prostanoid metabolic process 3/725 49/18722 0.294964878001428 0.523899205232997 MIF/AKR1B1/ANXA1 3 GO:0006693 prostaglandin metabolic process 3/725 49/18722 0.294964878001428 0.523899205232997 MIF/AKR1B1/ANXA1 3 GO:0007622 rhythmic behavior 3/725 49/18722 0.294964878001428 0.523899205232997 ADRB1/ZFHX3/NCOA2 3 GO:0009395 phospholipid catabolic process 3/725 49/18722 0.294964878001428 0.523899205232997 PRDX6/IDH1/GPCPD1 3 GO:0009994 oocyte differentiation 3/725 49/18722 0.294964878001428 0.523899205232997 LGR5/BCL2/ZFX 3 GO:0010823 negative regulation of mitochondrion organization 3/725 49/18722 0.294964878001428 0.523899205232997 TFRC/HSPA1A/HUWE1 3 GO:0014075 response to amine 3/725 49/18722 0.294964878001428 0.523899205232997 GLDC/CALM1/RANBP2 3 GO:0018198 peptidyl-cysteine modification 3/725 49/18722 0.294964878001428 0.523899205232997 GAPDH/S100A9/ADH5 3 GO:0021515 cell differentiation in spinal cord 3/725 49/18722 0.294964878001428 0.523899205232997 ISL1/SOX4/GLI3 3 GO:0030195 negative regulation of blood coagulation 3/725 49/18722 0.294964878001428 0.523899205232997 C1QTNF1/SERPINB2/SERPINE1 3 GO:0086009 membrane repolarization 3/725 49/18722 0.294964878001428 0.523899205232997 AKAP9/CAV1/GJA5 3 GO:0032722 positive regulation of chemokine production 4/725 71/18722 0.295572681632007 0.523899205232997 LRP1/APP/RIPK2/HMGB1 4 GO:0043550 regulation of lipid kinase activity 4/725 71/18722 0.295572681632007 0.523899205232997 SOCS1/CDC42/PIP4K2A/FLT1 4 GO:0050795 regulation of behavior 4/725 71/18722 0.295572681632007 0.523899205232997 ADRB1/GJA1/ARRDC3/ZFHX3 4 GO:0000423 mitophagy 2/725 28/18722 0.295797894136287 0.523899205232997 HUWE1/MAP1LC3B 2 GO:0006516 glycoprotein catabolic process 2/725 28/18722 0.295797894136287 0.523899205232997 CTSL/MANBA 2 GO:0006972 hyperosmotic response 2/725 28/18722 0.295797894136287 0.523899205232997 AKR1B1/EFHD1 2 GO:0007064 mitotic sister chromatid cohesion 2/725 28/18722 0.295797894136287 0.523899205232997 ATRX/NIPBL 2 GO:0009065 glutamine family amino acid catabolic process 2/725 28/18722 0.295797894136287 0.523899205232997 GLUL/ARG2 2 GO:0010575 positive regulation of vascular endothelial growth factor production 2/725 28/18722 0.295797894136287 0.523899205232997 ISL1/IL6ST 2 GO:0010714 positive regulation of collagen metabolic process 2/725 28/18722 0.295797894136287 0.523899205232997 SUCO/ENG 2 GO:0019098 reproductive behavior 2/725 28/18722 0.295797894136287 0.523899205232997 APP/ZFX 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 2/725 28/18722 0.295797894136287 0.523899205232997 EGFR/CBLB 2 GO:0042983 amyloid precursor protein biosynthetic process 2/725 28/18722 0.295797894136287 0.523899205232997 ITM2B/AGO2 2 GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/725 28/18722 0.295797894136287 0.523899205232997 ITM2B/AGO2 2 GO:0045589 regulation of regulatory T cell differentiation 2/725 28/18722 0.295797894136287 0.523899205232997 CD46/SOCS1 2 GO:0045671 negative regulation of osteoclast differentiation 2/725 28/18722 0.295797894136287 0.523899205232997 FBN1/FSTL3 2 GO:0045686 negative regulation of glial cell differentiation 2/725 28/18722 0.295797894136287 0.523899205232997 NF1/HES1 2 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 2/725 28/18722 0.295797894136287 0.523899205232997 CAV1/SOCS1 2 GO:0070076 histone lysine demethylation 2/725 28/18722 0.295797894136287 0.523899205232997 KDM5A/KDM5B 2 GO:0071280 cellular response to copper ion 2/725 28/18722 0.295797894136287 0.523899205232997 APP/NFE2L2 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/725 28/18722 0.295797894136287 0.523899205232997 AKAP9/GJA5 2 GO:1902624 positive regulation of neutrophil migration 2/725 28/18722 0.295797894136287 0.523899205232997 CD99/RAC1 2 GO:1903671 negative regulation of sprouting angiogenesis 2/725 28/18722 0.295797894136287 0.523899205232997 SEMA6A/PIK3CB 2 GO:1903672 positive regulation of sprouting angiogenesis 2/725 28/18722 0.295797894136287 0.523899205232997 PKM/HMGB1 2 GO:1903779 regulation of cardiac conduction 2/725 28/18722 0.295797894136287 0.523899205232997 ATP2B1/GJA5 2 GO:0007292 female gamete generation 7/725 140/18722 0.299476288626675 0.530155806761334 LGR5/RPS6/ADAMTS1/DIAPH2/BCL2/USP9X/ZFX 7 GO:0002690 positive regulation of leukocyte chemotaxis 5/725 94/18722 0.299644187486925 0.530155806761334 PGF/LGMN/HMGB1/SERPINE1/RAC1 5 GO:1903035 negative regulation of response to wounding 5/725 94/18722 0.299644187486925 0.530155806761334 GJA1/PHLDB2/C1QTNF1/SERPINB2/SERPINE1 5 GO:0014902 myotube differentiation 6/725 117/18722 0.300427237810556 0.531170445923163 ADAM12/HOMER1/BCL2/PLEC/GDF15/CFLAR 6 GO:1903828 negative regulation of cellular protein localization 6/725 117/18722 0.300427237810556 0.531170445923163 MAGED1/LMAN1/LATS2/CLTC/GOPC/TMBIM1 6 GO:0050806 positive regulation of synaptic transmission 8/725 164/18722 0.303230726713171 0.535940220958529 APP/KIF5B/EGFR/PPP1R9A/GLUL/LGMN/VAMP2/PAIP2 8 GO:0014743 regulation of muscle hypertrophy 4/725 72/18722 0.304350360273363 0.537169908156574 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:0033045 regulation of sister chromatid segregation 4/725 72/18722 0.304350360273363 0.537169908156574 DUSP1/NEK6/NUMA1/CENPF 4 GO:0070227 lymphocyte apoptotic process 4/725 72/18722 0.304350360273363 0.537169908156574 SLC39A10/RPS6/GLI3/ARG2 4 GO:1905818 regulation of chromosome separation 4/725 72/18722 0.304350360273363 0.537169908156574 DUSP1/NEK6/NUMA1/CENPF 4 GO:0006575 cellular modified amino acid metabolic process 9/725 188/18722 0.305621947932023 0.537793382189671 CLIC3/SLC6A8/CROT/NFE2L2/IDH1/GPX4/ARL6IP5/CLIC1/GSTO1 9 GO:0001961 positive regulation of cytokine-mediated signaling pathway 3/725 50/18722 0.305649235413002 0.537793382189671 TRIM44/HSPA1A/RIPK2 3 GO:0006220 pyrimidine nucleotide metabolic process 3/725 50/18722 0.305649235413002 0.537793382189671 UPP1/AK3/TDG 3 GO:0008089 anterograde axonal transport 3/725 50/18722 0.305649235413002 0.537793382189671 KIF5B/HSPB1/ARL8B 3 GO:0010665 regulation of cardiac muscle cell apoptotic process 3/725 50/18722 0.305649235413002 0.537793382189671 NFE2L2/PPP1R10/CFLAR 3 GO:0042572 retinol metabolic process 3/725 50/18722 0.305649235413002 0.537793382189671 AKR1B1/RDH10/RDH13 3 GO:0070231 T cell apoptotic process 3/725 50/18722 0.305649235413002 0.537793382189671 RPS6/GLI3/ARG2 3 GO:1900047 negative regulation of hemostasis 3/725 50/18722 0.305649235413002 0.537793382189671 C1QTNF1/SERPINB2/SERPINE1 3 GO:0034341 response to interferon-gamma 7/725 141/18722 0.30565846006874 0.537793382189671 GAPDH/KIF5B/RPL13A/SOCS1/ACTG1/FLNB/CDC42 7 GO:0007613 memory 6/725 118/18722 0.307221857226665 0.539665058731639 SLC6A4/LGMN/CEBPB/SERPINF1/SGK1/PAIP2 6 GO:0045446 endothelial cell differentiation 6/725 118/18722 0.307221857226665 0.539665058731639 MET/NR2F2/RBPJ/EDF1/EZR/ROCK1 6 GO:0051282 regulation of sequestering of calcium ion 6/725 118/18722 0.307221857226665 0.539665058731639 CALM1/ERO1A/DDIT3/SRI/GSTO1/CYBA 6 GO:0045666 positive regulation of neuron differentiation 5/725 95/18722 0.307254558985897 0.539665058731639 RHOA/BMP7/HMG20B/SPAG9/TIMP2 5 GO:0050764 regulation of phagocytosis 5/725 95/18722 0.307254558985897 0.539665058731639 LRP1/ITGAV/SYT7/HMGB1/CYBA 5 GO:0000209 protein polyubiquitination 11/725 236/18722 0.307830448200923 0.540489276733799 SKP1/TRIM44/BCL2/MDM2/HUWE1/SASH1/DDA1/TTC3/UBE2D3/PPIA/UBE2A 11 GO:0006260 DNA replication 12/725 260/18722 0.308089686467278 0.54075714013249 S100A11/JUN/EGFR/NASP/ZBTB38/ATRX/BOD1L1/CDC42/PURA/HRAS/RAC1/PTMS 12 GO:0006656 phosphatidylcholine biosynthetic process 2/725 29/18722 0.310264652347813 0.541760772563233 CHPT1/CDS1 2 GO:0009218 pyrimidine ribonucleotide metabolic process 2/725 29/18722 0.310264652347813 0.541760772563233 UPP1/AK3 2 GO:0010390 histone monoubiquitination 2/725 29/18722 0.310264652347813 0.541760772563233 DDB1/SKP1 2 GO:0035066 positive regulation of histone acetylation 2/725 29/18722 0.310264652347813 0.541760772563233 ISL1/BRD7 2 GO:0042759 long-chain fatty acid biosynthetic process 2/725 29/18722 0.310264652347813 0.541760772563233 GPX4/QKI 2 GO:0048665 neuron fate specification 2/725 29/18722 0.310264652347813 0.541760772563233 ISL1/GLI3 2 GO:0060969 negative regulation of gene silencing 2/725 29/18722 0.310264652347813 0.541760772563233 NEAT1/KCNQ1OT1 2 GO:0062098 regulation of programmed necrotic cell death 2/725 29/18722 0.310264652347813 0.541760772563233 CAV1/CFLAR 2 GO:0070979 protein K11-linked ubiquitination 2/725 29/18722 0.310264652347813 0.541760772563233 UBE2D3/UBE2A 2 GO:0090114 COPII-coated vesicle budding 2/725 29/18722 0.310264652347813 0.541760772563233 PDCD6/RAB1A 2 GO:0095500 acetylcholine receptor signaling pathway 2/725 29/18722 0.310264652347813 0.541760772563233 GNAQ/LY6E 2 GO:1902430 negative regulation of amyloid-beta formation 2/725 29/18722 0.310264652347813 0.541760772563233 ROCK1/RTN4 2 GO:1903902 positive regulation of viral life cycle 2/725 29/18722 0.310264652347813 0.541760772563233 DDB1/P4HB 2 GO:2000406 positive regulation of T cell migration 2/725 29/18722 0.310264652347813 0.541760772563233 APP/RHOA 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/725 29/18722 0.310264652347813 0.541760772563233 PRKDC/DEK 2 GO:0043583 ear development 10/725 213/18722 0.312107716523613 0.543089119548589 LGR5/RBPJ/TRIOBP/GLI3/RDH10/BCL2/TRIP11/NIPBL/TFAP2A/HES1 10 GO:0007018 microtubule-based movement 17/725 382/18722 0.312589407949797 0.543089119548589 ARMCX3/APP/KIF5B/HSPA8/DST/NEURL1/KTN1/DYNC1H1/HSPB1/ASH1L/DYNLRB1/KPNB1/CDC42/PURA/CCSAP/RAB1A/ARL8B 17 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 4/725 73/18722 0.313155582347407 0.543089119548589 EGFR/NEURL1/PTPN12/CBLB 4 GO:0051865 protein autoubiquitination 4/725 73/18722 0.313155582347407 0.543089119548589 MDM2/SASH1/UBE2D3/UBE2A 4 GO:1904427 positive regulation of calcium ion transmembrane transport 4/725 73/18722 0.313155582347407 0.543089119548589 CALM1/SLC9A1/SRI/GSTO1 4 GO:0030282 bone mineralization 6/725 119/18722 0.314042908487094 0.543089119548589 ATP2B1/FBN2/LGR4/BMP7/GPC3/TFAP2A 6 GO:1904035 regulation of epithelial cell apoptotic process 5/725 96/18722 0.314892353839433 0.543089119548589 PDCD4/NFE2L2/SRSF6/CFLAR/SERPINE1 5 GO:0051216 cartilage development 9/725 190/18722 0.3163455343166 0.543089119548589 GLG1/EFEMP1/GLI3/BMP7/ESRRA/BGN/GHR/TRIP11/SERPINH1 9 GO:0006636 unsaturated fatty acid biosynthetic process 3/725 51/18722 0.316348422672991 0.543089119548589 MIF/ANXA1/SCD 3 GO:0009584 detection of visible light 3/725 51/18722 0.316348422672991 0.543089119548589 OPN3/NMT1/GNAQ 3 GO:0032964 collagen biosynthetic process 3/725 51/18722 0.316348422672991 0.543089119548589 SUCO/SERPINH1/ENG 3 GO:0045661 regulation of myoblast differentiation 3/725 51/18722 0.316348422672991 0.543089119548589 IGFBP3/TBX3/DDIT3 3 GO:0048013 ephrin receptor signaling pathway 3/725 51/18722 0.316348422672991 0.543089119548589 EPHB4/RBPJ/RASA1 3 GO:0060043 regulation of cardiac muscle cell proliferation 3/725 51/18722 0.316348422672991 0.543089119548589 TGFBR3/GJA1/RBPJ 3 GO:0044242 cellular lipid catabolic process 10/725 214/18722 0.317167691792505 0.543089119548589 PRDX6/LRP1/SLC27A2/CROT/IDH1/LPIN2/HEXA/GPCPD1/HADHA/ECHDC2 10 GO:0070555 response to interleukin-1 7/725 143/18722 0.318096712696531 0.543089119548589 APP/ANXA1/USP10/CEBPB/GHR/RIPK2/CYBA 7 GO:0006635 fatty acid beta-oxidation 4/725 74/18722 0.321983157596996 0.543089119548589 SLC27A2/CROT/HADHA/ECHDC2 4 GO:0009201 ribonucleoside triphosphate biosynthetic process 4/725 74/18722 0.321983157596996 0.543089119548589 ALDOA/PARP1/TMSB4X/ENO1 4 GO:0010596 negative regulation of endothelial cell migration 5/725 97/18722 0.322554146171651 0.543089119548589 NR2F2/RHOA/CSNK2B/SERPINF1/HMGB1 5 GO:0043255 regulation of carbohydrate biosynthetic process 5/725 97/18722 0.322554146171651 0.543089119548589 IGF2/DDB1/CLTC/SLC35B4/RANBP2 5 GO:0031644 regulation of nervous system process 7/725 144/18722 0.324349079104808 0.543089119548589 AKAP9/APP/DAG1/CTSC/HOMER1/DICER1/SLC9A1 7 GO:0006099 tricarboxylic acid cycle 2/725 30/18722 0.324668557756967 0.543089119548589 IDH1/SDHA 2 GO:0006884 cell volume homeostasis 2/725 30/18722 0.324668557756967 0.543089119548589 KCNN4/NPM1 2 GO:0007202 activation of phospholipase C activity 2/725 30/18722 0.324668557756967 0.543089119548589 EGFR/GNAQ 2 GO:0008209 androgen metabolic process 2/725 30/18722 0.324668557756967 0.543089119548589 HSD3B1/CYP19A1 2 GO:0019674 NAD metabolic process 2/725 30/18722 0.324668557756967 0.543089119548589 LDHA/ENO1 2 GO:0030204 chondroitin sulfate metabolic process 2/725 30/18722 0.324668557756967 0.543089119548589 BGN/CHST12 2 GO:0031365 N-terminal protein amino acid modification 2/725 30/18722 0.324668557756967 0.543089119548589 SOX4/NMT1 2 GO:0034390 smooth muscle cell apoptotic process 2/725 30/18722 0.324668557756967 0.543089119548589 PDCD4/DNMT1 2 GO:0034391 regulation of smooth muscle cell apoptotic process 2/725 30/18722 0.324668557756967 0.543089119548589 PDCD4/DNMT1 2 GO:0034508 centromere complex assembly 2/725 30/18722 0.324668557756967 0.543089119548589 NASP/CENPF 2 GO:0045948 positive regulation of translational initiation 2/725 30/18722 0.324668557756967 0.543089119548589 LARP1/PPP1R15A 2 GO:0046825 regulation of protein export from nucleus 2/725 30/18722 0.324668557756967 0.543089119548589 PTPN14/MDM2 2 GO:0048147 negative regulation of fibroblast proliferation 2/725 30/18722 0.324668557756967 0.543089119548589 FTH1/NF1 2 GO:0051125 regulation of actin nucleation 2/725 30/18722 0.324668557756967 0.543089119548589 WASF2/ARF1 2 GO:0051491 positive regulation of filopodium assembly 2/725 30/18722 0.324668557756967 0.543089119548589 NEURL1/CDC42 2 GO:0051968 positive regulation of synaptic transmission, glutamatergic 2/725 30/18722 0.324668557756967 0.543089119548589 EGFR/GLUL 2 GO:0060292 long-term synaptic depression 2/725 30/18722 0.324668557756967 0.543089119548589 PPP1R9A/ARF1 2 GO:0061311 cell surface receptor signaling pathway involved in heart development 2/725 30/18722 0.324668557756967 0.543089119548589 GALNT11/RBPJ 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/725 30/18722 0.324668557756967 0.543089119548589 SLC39A10/ARG2 2 GO:0090151 establishment of protein localization to mitochondrial membrane 2/725 30/18722 0.324668557756967 0.543089119548589 CALM1/NMT1 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/725 30/18722 0.324668557756967 0.543089119548589 ITM2B/AGO2 2 GO:1903579 negative regulation of ATP metabolic process 2/725 30/18722 0.324668557756967 0.543089119548589 PARP1/RHOA 2 GO:0000070 mitotic sister chromatid segregation 8/725 168/18722 0.326256281651105 0.543089119548589 DUSP1/ATRX/NIPBL/KPNB1/NEK6/NUMA1/RAB11A/CENPF 8 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/725 168/18722 0.326256281651105 0.543089119548589 CD46/TFRC/HSPD1/ANXA1/CD55/RIPK2/HMGB1/B2M 8 GO:0002833 positive regulation of response to biotic stimulus 8/725 168/18722 0.326256281651105 0.543089119548589 HSPD1/PRKDC/GRN/RPS19/PUM1/SASH1/HMGB1/CYBA 8 GO:2000241 regulation of reproductive process 8/725 168/18722 0.326256281651105 0.543089119548589 SYDE1/DUSP1/GJA1/PHLDA2/BMP7/APELA/SERPINF1/AGO2 8 GO:0000050 urea cycle 1/725 10/18722 0.326346312516276 0.543089119548589 ARG2 1 GO:0000255 allantoin metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 PNP 1 GO:0000492 box C/D snoRNP assembly 1/725 10/18722 0.326346312516276 0.543089119548589 SNU13 1 GO:0001820 serotonin secretion 1/725 10/18722 0.326346312516276 0.543089119548589 SLC6A4 1 GO:0002934 desmosome organization 1/725 10/18722 0.326346312516276 0.543089119548589 DSG2 1 GO:0003183 mitral valve morphogenesis 1/725 10/18722 0.326346312516276 0.543089119548589 SOX4 1 GO:0005984 disaccharide metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 GAA 1 GO:0006222 UMP biosynthetic process 1/725 10/18722 0.326346312516276 0.543089119548589 UPP1 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/725 10/18722 0.326346312516276 0.543089119548589 PISD 1 GO:0006735 NADH regeneration 1/725 10/18722 0.326346312516276 0.543089119548589 ENO1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/725 10/18722 0.326346312516276 0.543089119548589 AK3 1 GO:0009169 purine ribonucleoside monophosphate catabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 PNP 1 GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 PNP 1 GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 1/725 10/18722 0.326346312516276 0.543089119548589 UPP1 1 GO:0009750 response to fructose 1/725 10/18722 0.326346312516276 0.543089119548589 KRT18 1 GO:0010944 negative regulation of transcription by competitive promoter binding 1/725 10/18722 0.326346312516276 0.543089119548589 TFAP2A 1 GO:0010968 regulation of microtubule nucleation 1/725 10/18722 0.326346312516276 0.543089119548589 HSPA1A 1 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 1/725 10/18722 0.326346312516276 0.543089119548589 NPM1 1 GO:0014041 regulation of neuron maturation 1/725 10/18722 0.326346312516276 0.543089119548589 BCL2 1 GO:0017085 response to insecticide 1/725 10/18722 0.326346312516276 0.543089119548589 UBA52 1 GO:0019532 oxalate transport 1/725 10/18722 0.326346312516276 0.543089119548589 SLC26A2 1 GO:0019614 catechol-containing compound catabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 MAOA 1 GO:0021548 pons development 1/725 10/18722 0.326346312516276 0.543089119548589 BCL2 1 GO:0021562 vestibulocochlear nerve development 1/725 10/18722 0.326346312516276 0.543089119548589 NRP2 1 GO:0022400 regulation of rhodopsin mediated signaling pathway 1/725 10/18722 0.326346312516276 0.543089119548589 NMT1 1 GO:0030388 fructose 1,6-bisphosphate metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 ALDOA 1 GO:0030638 polyketide metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 AKR1B1 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 AKR1B1 1 GO:0031055 chromatin remodeling at centromere 1/725 10/18722 0.326346312516276 0.543089119548589 NASP 1 GO:0031118 rRNA pseudouridine synthesis 1/725 10/18722 0.326346312516276 0.543089119548589 NOP10 1 GO:0031125 rRNA 3'-end processing 1/725 10/18722 0.326346312516276 0.543089119548589 RPS21 1 GO:0031642 negative regulation of myelination 1/725 10/18722 0.326346312516276 0.543089119548589 CTSC 1 GO:0032025 response to cobalt ion 1/725 10/18722 0.326346312516276 0.543089119548589 SERPINF1 1 GO:0032253 dense core granule localization 1/725 10/18722 0.326346312516276 0.543089119548589 KIF5B 1 GO:0032275 luteinizing hormone secretion 1/725 10/18722 0.326346312516276 0.543089119548589 TBX3 1 GO:0033131 regulation of glucokinase activity 1/725 10/18722 0.326346312516276 0.543089119548589 RANBP2 1 GO:0034085 establishment of sister chromatid cohesion 1/725 10/18722 0.326346312516276 0.543089119548589 NIPBL 1 GO:0034756 regulation of iron ion transport 1/725 10/18722 0.326346312516276 0.543089119548589 B2M 1 GO:0035376 sterol import 1/725 10/18722 0.326346312516276 0.543089119548589 LRP1 1 GO:0035646 endosome to melanosome transport 1/725 10/18722 0.326346312516276 0.543089119548589 CD63 1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 1/725 10/18722 0.326346312516276 0.543089119548589 GDF15 1 GO:0042424 catecholamine catabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 MAOA 1 GO:0042989 sequestering of actin monomers 1/725 10/18722 0.326346312516276 0.543089119548589 TMSB4X 1 GO:0042996 regulation of Golgi to plasma membrane protein transport 1/725 10/18722 0.326346312516276 0.543089119548589 GOPC 1 GO:0043101 purine-containing compound salvage 1/725 10/18722 0.326346312516276 0.543089119548589 PNP 1 GO:0043485 endosome to pigment granule transport 1/725 10/18722 0.326346312516276 0.543089119548589 CD63 1 GO:0044598 doxorubicin metabolic process 1/725 10/18722 0.326346312516276 0.543089119548589 AKR1B1 1 GO:0045792 negative regulation of cell size 1/725 10/18722 0.326346312516276 0.543089119548589 RHOA 1 GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 1/725 10/18722 0.326346312516276 0.543089119548589 HMGB1 1 GO:0048241 epinephrine transport 1/725 10/18722 0.326346312516276 0.543089119548589 LY6E 1 GO:0048262 determination of dorsal/ventral asymmetry 1/725 10/18722 0.326346312516276 0.543089119548589 DDIT3 1 GO:0048672 positive regulation of collateral sprouting 1/725 10/18722 0.326346312516276 0.543089119548589 LRP1 1 GO:0048757 pigment granule maturation 1/725 10/18722 0.326346312516276 0.543089119548589 CD63 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/725 10/18722 0.326346312516276 0.543089119548589 SLC39A10 1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 1/725 10/18722 0.326346312516276 0.543089119548589 CALM1 1 GO:0051351 positive regulation of ligase activity 1/725 10/18722 0.326346312516276 0.543089119548589 TMSB4X 1 GO:0051918 negative regulation of fibrinolysis 1/725 10/18722 0.326346312516276 0.543089119548589 SERPINE1 1 GO:0060068 vagina development 1/725 10/18722 0.326346312516276 0.543089119548589 LRP2 1 GO:0060272 embryonic skeletal joint morphogenesis 1/725 10/18722 0.326346312516276 0.543089119548589 BMP7 1 GO:0060513 prostatic bud formation 1/725 10/18722 0.326346312516276 0.543089119548589 BMP7 1 GO:0060736 prostate gland growth 1/725 10/18722 0.326346312516276 0.543089119548589 PSAP 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/725 10/18722 0.326346312516276 0.543089119548589 SERPINF1 1 GO:0061299 retina vasculature morphogenesis in camera-type eye 1/725 10/18722 0.326346312516276 0.543089119548589 LRP5 1 GO:0061621 canonical glycolysis 1/725 10/18722 0.326346312516276 0.543089119548589 ENO1 1 GO:0061718 glucose catabolic process to pyruvate 1/725 10/18722 0.326346312516276 0.543089119548589 ENO1 1 GO:0070091 glucagon secretion 1/725 10/18722 0.326346312516276 0.543089119548589 SYT7 1 GO:0070092 regulation of glucagon secretion 1/725 10/18722 0.326346312516276 0.543089119548589 SYT7 1 GO:0070391 response to lipoteichoic acid 1/725 10/18722 0.326346312516276 0.543089119548589 RIPK2 1 GO:0070508 cholesterol import 1/725 10/18722 0.326346312516276 0.543089119548589 LRP1 1 GO:0071223 cellular response to lipoteichoic acid 1/725 10/18722 0.326346312516276 0.543089119548589 RIPK2 1 GO:0071803 positive regulation of podosome assembly 1/725 10/18722 0.326346312516276 0.543089119548589 RHOA 1 GO:0072070 loop of Henle development 1/725 10/18722 0.326346312516276 0.543089119548589 IRX2 1 GO:0072178 nephric duct morphogenesis 1/725 10/18722 0.326346312516276 0.543089119548589 GPC3 1 GO:0072378 blood coagulation, fibrin clot formation 1/725 10/18722 0.326346312516276 0.543089119548589 FBLN1 1 GO:0097250 mitochondrial respirasome assembly 1/725 10/18722 0.326346312516276 0.543089119548589 HIGD1A 1 GO:0097278 complement-dependent cytotoxicity 1/725 10/18722 0.326346312516276 0.543089119548589 CD55 1 GO:0098903 regulation of membrane repolarization during action potential 1/725 10/18722 0.326346312516276 0.543089119548589 CAV1 1 GO:0098917 retrograde trans-synaptic signaling 1/725 10/18722 0.326346312516276 0.543089119548589 DAG1 1 GO:0099171 presynaptic modulation of chemical synaptic transmission 1/725 10/18722 0.326346312516276 0.543089119548589 RPL22 1 GO:0099519 dense core granule cytoskeletal transport 1/725 10/18722 0.326346312516276 0.543089119548589 KIF5B 1 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/725 10/18722 0.326346312516276 0.543089119548589 RAB11A 1 GO:1900246 positive regulation of RIG-I signaling pathway 1/725 10/18722 0.326346312516276 0.543089119548589 PUM1 1 GO:1901725 regulation of histone deacetylase activity 1/725 10/18722 0.326346312516276 0.543089119548589 KDM5A 1 GO:1901950 dense core granule transport 1/725 10/18722 0.326346312516276 0.543089119548589 KIF5B 1 GO:1902023 L-arginine transport 1/725 10/18722 0.326346312516276 0.543089119548589 SLC38A9 1 GO:1902946 protein localization to early endosome 1/725 10/18722 0.326346312516276 0.543089119548589 EZR 1 GO:1903826 arginine transmembrane transport 1/725 10/18722 0.326346312516276 0.543089119548589 SLC38A9 1 GO:1903980 positive regulation of microglial cell activation 1/725 10/18722 0.326346312516276 0.543089119548589 CTSC 1 GO:1904668 positive regulation of ubiquitin protein ligase activity 1/725 10/18722 0.326346312516276 0.543089119548589 SKP1 1 GO:1905456 regulation of lymphoid progenitor cell differentiation 1/725 10/18722 0.326346312516276 0.543089119548589 HES1 1 GO:1990535 neuron projection maintenance 1/725 10/18722 0.326346312516276 0.543089119548589 APP 1 GO:2000288 positive regulation of myoblast proliferation 1/725 10/18722 0.326346312516276 0.543089119548589 MALAT1 1 GO:2000425 regulation of apoptotic cell clearance 1/725 10/18722 0.326346312516276 0.543089119548589 HMGB1 1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 1/725 10/18722 0.326346312516276 0.543089119548589 WASF2 1 GO:2000674 regulation of type B pancreatic cell apoptotic process 1/725 10/18722 0.326346312516276 0.543089119548589 SRSF6 1 GO:2001223 negative regulation of neuron migration 1/725 10/18722 0.326346312516276 0.543089119548589 ADGRG1 1 GO:0043090 amino acid import 3/725 52/18722 0.327053691149595 0.543730784006984 ITGB1/ARL6IP5/SLC7A5 3 GO:0051496 positive regulation of stress fiber assembly 3/725 52/18722 0.327053691149595 0.543730784006984 RHOA/CDC42/RAC1 3 GO:0072523 purine-containing compound catabolic process 3/725 52/18722 0.327053691149595 0.543730784006984 PNP/PDE4B/HINT1 3 GO:0032642 regulation of chemokine production 5/725 98/18722 0.330236551307373 0.548842320844942 LRP1/APP/RIPK2/HMGB1/ARG2 5 GO:0034660 ncRNA metabolic process 21/725 485/18722 0.330481685342527 0.549069702720836 RPS21/RPL14/KCNQ1OT1/PRKDC/RPS6/RPS16/RPS8/RPS25/IARS2/RPL26/RPS19/RPL10A/DICER1/DDX17/RPL7A/RPL7/HRAS/RPL27/AGO2/SNU13/NOP10 21 GO:0002292 T cell differentiation involved in immune response 4/725 75/18722 0.330828001186276 0.549105153245983 CD46/ANXA1/RIPK2/HMGB1 4 GO:1902369 negative regulation of RNA catabolic process 4/725 75/18722 0.330828001186276 0.549105153245983 FUS/DHX36/LARP1/YBX1 4 GO:2001259 positive regulation of cation channel activity 4/725 75/18722 0.330828001186276 0.549105153245983 KIF5B/CALM1/TMSB4X/GSTO1 4 GO:0006813 potassium ion transport 11/725 241/18722 0.331883322782025 0.550612377211554 AKAP9/CAV1/ITGB1/FXYD3/CD63/KIF5B/KCNN4/GJA5/SLC9A1/DLG1/VAMP2 11 GO:0000075 cell cycle checkpoint signaling 8/725 169/18722 0.33206195248288 0.550612377211554 PRKDC/DUSP1/SOX4/RPL26/PPP1R10/MDM2/CDKN1A/CENPF 8 GO:0009152 purine ribonucleotide biosynthetic process 8/725 169/18722 0.33206195248288 0.550612377211554 SLC26A2/ALDOA/ACSS1/PARP1/TMSB4X/ENO1/MPC2/AK3 8 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 7/725 146/18722 0.336911060225756 0.552941695312018 ADGRG1/LGR5/LGR4/ADRB1/ARRDC3/PDE4B/GNAQ 7 GO:0002707 negative regulation of lymphocyte mediated immunity 3/725 53/18722 0.337756620178132 0.552941695312018 SERPINB9/CD46/CD55 3 GO:0032210 regulation of telomere maintenance via telomerase 3/725 53/18722 0.337756620178132 0.552941695312018 MAP3K4/PKIB/HNRNPA1 3 GO:0050819 negative regulation of coagulation 3/725 53/18722 0.337756620178132 0.552941695312018 C1QTNF1/SERPINB2/SERPINE1 3 GO:0007259 receptor signaling pathway via JAK-STAT 8/725 170/18722 0.337884424605617 0.552941695312018 CAV1/AKR1B1/ISL1/CSH1/IL6ST/SOCS1/GHR/HES1 8 GO:0000045 autophagosome assembly 5/725 99/18722 0.337936228795067 0.552941695312018 RALB/TMEM41B/PIP4K2A/RAB1A/MAP1LC3B 5 GO:0032602 chemokine production 5/725 99/18722 0.337936228795067 0.552941695312018 LRP1/APP/RIPK2/HMGB1/ARG2 5 GO:0033209 tumor necrosis factor-mediated signaling pathway 5/725 99/18722 0.337936228795067 0.552941695312018 KRT8/KRT18/TMSB4X/HSPA1A/EIF5A 5 GO:0060291 long-term synaptic potentiation 5/725 99/18722 0.337936228795067 0.552941695312018 APP/PPP1R9A/LGMN/VAMP2/PAIP2 5 GO:0001516 prostaglandin biosynthetic process 2/725 31/18722 0.338992799898013 0.552941695312018 MIF/ANXA1 2 GO:0002828 regulation of type 2 immune response 2/725 31/18722 0.338992799898013 0.552941695312018 ANXA1/ARG2 2 GO:0006301 postreplication repair 2/725 31/18722 0.338992799898013 0.552941695312018 USP10/UBE2A 2 GO:0008045 motor neuron axon guidance 2/725 31/18722 0.338992799898013 0.552941695312018 MYCBP2/RAC1 2 GO:0016577 histone demethylation 2/725 31/18722 0.338992799898013 0.552941695312018 KDM5A/KDM5B 2 GO:0030212 hyaluronan metabolic process 2/725 31/18722 0.338992799898013 0.552941695312018 ITIH5/CLTC 2 GO:0031063 regulation of histone deacetylation 2/725 31/18722 0.338992799898013 0.552941695312018 NIPBL/KDM5A 2 GO:0034656 nucleobase-containing small molecule catabolic process 2/725 31/18722 0.338992799898013 0.552941695312018 UPP1/PNP 2 GO:0036474 cell death in response to hydrogen peroxide 2/725 31/18722 0.338992799898013 0.552941695312018 MET/NFE2L2 2 GO:0036475 neuron death in response to oxidative stress 2/725 31/18722 0.338992799898013 0.552941695312018 PARP1/ARL6IP5 2 GO:0042133 neurotransmitter metabolic process 2/725 31/18722 0.338992799898013 0.552941695312018 SLC6A4/MAOA 2 GO:0045066 regulatory T cell differentiation 2/725 31/18722 0.338992799898013 0.552941695312018 CD46/SOCS1 2 GO:0046457 prostanoid biosynthetic process 2/725 31/18722 0.338992799898013 0.552941695312018 MIF/ANXA1 2 GO:0048566 embryonic digestive tract development 2/725 31/18722 0.338992799898013 0.552941695312018 GLI3/NIPBL 2 GO:0048710 regulation of astrocyte differentiation 2/725 31/18722 0.338992799898013 0.552941695312018 IL6ST/HES1 2 GO:0051569 regulation of histone H3-K4 methylation 2/725 31/18722 0.338992799898013 0.552941695312018 RTF1/DNMT1 2 GO:0060045 positive regulation of cardiac muscle cell proliferation 2/725 31/18722 0.338992799898013 0.552941695312018 TGFBR3/RBPJ 2 GO:0060055 angiogenesis involved in wound healing 2/725 31/18722 0.338992799898013 0.552941695312018 DAG1/SERPINE1 2 GO:0060390 regulation of SMAD protein signal transduction 2/725 31/18722 0.338992799898013 0.552941695312018 LRP1/PARP1 2 GO:0061099 negative regulation of protein tyrosine kinase activity 2/725 31/18722 0.338992799898013 0.552941695312018 CAV1/CBLB 2 GO:0070633 transepithelial transport 2/725 31/18722 0.338992799898013 0.552941695312018 ABCB1/ACTG1 2 GO:0071168 protein localization to chromatin 2/725 31/18722 0.338992799898013 0.552941695312018 NIPBL/SETD2 2 GO:1905144 response to acetylcholine 2/725 31/18722 0.338992799898013 0.552941695312018 GNAQ/LY6E 2 GO:1905145 cellular response to acetylcholine 2/725 31/18722 0.338992799898013 0.552941695312018 GNAQ/LY6E 2 GO:0006809 nitric oxide biosynthetic process 4/725 76/18722 0.339685137844844 0.552941695312018 DYNLL1/CAV1/RAC1/ARG2 4 GO:0014855 striated muscle cell proliferation 4/725 76/18722 0.339685137844844 0.552941695312018 TGFBR3/GJA1/RBPJ/CFLAR 4 GO:0071426 ribonucleoprotein complex export from nucleus 4/725 76/18722 0.339685137844844 0.552941695312018 NPM1/PABPN1/UPF2/SETD2 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/725 76/18722 0.339685137844844 0.552941695312018 EGFR/NFE2L2/CDKN1A/CYBA 4 GO:0031570 DNA integrity checkpoint signaling 6/725 123/18722 0.34154255424709 0.552941695312018 PRKDC/SOX4/RPL26/PPP1R10/MDM2/CDKN1A 6 GO:0000280 nuclear division 19/725 439/18722 0.342070304356394 0.552941695312018 RPL24/IGF2/DUSP1/RHOA/LRP5/BMP7/ATRX/RAD50/HSPA1A/NIPBL/KPNB1/CDC42/STAG1/SLC2A8/NEK6/NUMA1/RAB11A/CCSAP/CENPF 19 GO:1902652 secondary alcohol metabolic process 7/725 147/18722 0.343217010144646 0.552941695312018 APP/CYP11A1/DHCR24/IDH1/LRP5/CAT/FDX1 7 GO:0006626 protein targeting to mitochondrion 5/725 100/18722 0.345649885241485 0.552941695312018 HSPD1/LMAN1/BNIP3L/HUWE1/UBE2D3 5 GO:0009062 fatty acid catabolic process 5/725 100/18722 0.345649885241485 0.552941695312018 SLC27A2/CROT/LPIN2/HADHA/ECHDC2 5 GO:0006584 catecholamine metabolic process 3/725 54/18722 0.348449117403357 0.552941695312018 AKR1B1/MAOA/LY6E 3 GO:0009712 catechol-containing compound metabolic process 3/725 54/18722 0.348449117403357 0.552941695312018 AKR1B1/MAOA/LY6E 3 GO:0010659 cardiac muscle cell apoptotic process 3/725 54/18722 0.348449117403357 0.552941695312018 NFE2L2/PPP1R10/CFLAR 3 GO:0032330 regulation of chondrocyte differentiation 3/725 54/18722 0.348449117403357 0.552941695312018 GLG1/EFEMP1/GLI3 3 GO:0060350 endochondral bone morphogenesis 3/725 54/18722 0.348449117403357 0.552941695312018 GHR/TRIP11/SERPINH1 3 GO:2000179 positive regulation of neural precursor cell proliferation 3/725 54/18722 0.348449117403357 0.552941695312018 ADGRG1/LRP2/GLI3 3 GO:0002200 somatic diversification of immune receptors 4/725 77/18722 0.348549705565834 0.552941695312018 TFRC/HSPD1/PRKDC/HMGB1 4 GO:0006367 transcription initiation from RNA polymerase II promoter 4/725 77/18722 0.348549705565834 0.552941695312018 ZNF451/DHX36/HMGB1/SUB1 4 GO:0032418 lysosome localization 4/725 77/18722 0.348549705565834 0.552941695312018 KIF5B/SPAG9/TFEB/ARL8B 4 GO:0071166 ribonucleoprotein complex localization 4/725 77/18722 0.348549705565834 0.552941695312018 NPM1/PABPN1/UPF2/SETD2 4 GO:0009615 response to virus 16/725 367/18722 0.349316530396386 0.552941695312018 TPT1/PMAIP1/NCBP3/ENO1/HSPB1/BNIP3L/TRIM44/DHX36/PUM1/BCL2/CFL1/DDX17/EXOC1/SETD2/EIF5A/ARF1 16 GO:0001765 membrane raft assembly 1/725 11/18722 0.352447152801959 0.552941695312018 CAV1 1 GO:0001967 suckling behavior 1/725 11/18722 0.352447152801959 0.552941695312018 APP 1 GO:0002645 positive regulation of tolerance induction 1/725 11/18722 0.352447152801959 0.552941695312018 CBLB 1 GO:0002732 positive regulation of dendritic cell cytokine production 1/725 11/18722 0.352447152801959 0.552941695312018 DHX36 1 GO:0003157 endocardium development 1/725 11/18722 0.352447152801959 0.552941695312018 RBPJ 1 GO:0006020 inositol metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 ISYNA1 1 GO:0006054 N-acetylneuraminate metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 NAGK 1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 1/725 11/18722 0.352447152801959 0.552941695312018 MPC2 1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1/725 11/18722 0.352447152801959 0.552941695312018 UQCRH 1 GO:0006449 regulation of translational termination 1/725 11/18722 0.352447152801959 0.552941695312018 EIF5A 1 GO:0006527 arginine catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 ARG2 1 GO:0006702 androgen biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 HSD3B1 1 GO:0008611 ether lipid biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 CHPT1 1 GO:0009120 deoxyribonucleoside metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0009128 purine nucleoside monophosphate catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0009155 purine deoxyribonucleotide catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0009235 cobalamin metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 MTR 1 GO:0009313 oligosaccharide catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 MANBA 1 GO:0010739 positive regulation of protein kinase A signaling 1/725 11/18722 0.352447152801959 0.552941695312018 MIF 1 GO:0014010 Schwann cell proliferation 1/725 11/18722 0.352447152801959 0.552941695312018 DICER1 1 GO:0018026 peptidyl-lysine monomethylation 1/725 11/18722 0.352447152801959 0.552941695312018 SETD2 1 GO:0018342 protein prenylation 1/725 11/18722 0.352447152801959 0.552941695312018 CHML 1 GO:0019048 modulation by virus of host process 1/725 11/18722 0.352447152801959 0.552941695312018 DAG1 1 GO:0019372 lipoxygenase pathway 1/725 11/18722 0.352447152801959 0.552941695312018 GPX4 1 GO:0021561 facial nerve development 1/725 11/18722 0.352447152801959 0.552941695312018 NRP2 1 GO:0021604 cranial nerve structural organization 1/725 11/18722 0.352447152801959 0.552941695312018 NRP2 1 GO:0021610 facial nerve morphogenesis 1/725 11/18722 0.352447152801959 0.552941695312018 NRP2 1 GO:0030210 heparin biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 GLCE 1 GO:0030656 regulation of vitamin metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 RDH10 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/725 11/18722 0.352447152801959 0.552941695312018 DHX36 1 GO:0032610 interleukin-1 alpha production 1/725 11/18722 0.352447152801959 0.552941695312018 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/725 11/18722 0.352447152801959 0.552941695312018 ISL1 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/725 11/18722 0.352447152801959 0.552941695312018 BCL2 1 GO:0033083 regulation of immature T cell proliferation 1/725 11/18722 0.352447152801959 0.552941695312018 RIPK2 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/725 11/18722 0.352447152801959 0.552941695312018 PARP1 1 GO:0033197 response to vitamin E 1/725 11/18722 0.352447152801959 0.552941695312018 CAT 1 GO:0033234 negative regulation of protein sumoylation 1/725 11/18722 0.352447152801959 0.552941695312018 HMG20B 1 GO:0033327 Leydig cell differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 SF1 1 GO:0033483 gas homeostasis 1/725 11/18722 0.352447152801959 0.552941695312018 CAV1 1 GO:0034379 very-low-density lipoprotein particle assembly 1/725 11/18722 0.352447152801959 0.552941695312018 ARF1 1 GO:0034454 microtubule anchoring at centrosome 1/725 11/18722 0.352447152801959 0.552941695312018 HOOK3 1 GO:0034650 cortisol metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 CYP11A1 1 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 1/725 11/18722 0.352447152801959 0.552941695312018 PPP1R15A 1 GO:0042135 neurotransmitter catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 MAOA 1 GO:0042447 hormone catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 CYP19A1 1 GO:0042451 purine nucleoside biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0042455 ribonucleoside biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1/725 11/18722 0.352447152801959 0.552941695312018 NFE2L2 1 GO:0044068 modulation by symbiont of host cellular process 1/725 11/18722 0.352447152801959 0.552941695312018 SERPINB9 1 GO:0045060 negative thymic T cell selection 1/725 11/18722 0.352447152801959 0.552941695312018 GLI3 1 GO:0045628 regulation of T-helper 2 cell differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 ANXA1 1 GO:0045654 positive regulation of megakaryocyte differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 RCOR1 1 GO:0045657 positive regulation of monocyte differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 JUN 1 GO:0046129 purine ribonucleoside biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 PNP 1 GO:0046504 glycerol ether biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 CHPT1 1 GO:0046598 positive regulation of viral entry into host cell 1/725 11/18722 0.352447152801959 0.552941695312018 P4HB 1 GO:0046643 regulation of gamma-delta T cell activation 1/725 11/18722 0.352447152801959 0.552941695312018 SOX4 1 GO:0046710 GDP metabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 DLG1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/725 11/18722 0.352447152801959 0.552941695312018 PPP1R9A 1 GO:0048102 autophagic cell death 1/725 11/18722 0.352447152801959 0.552941695312018 CTSV 1 GO:0048853 forebrain morphogenesis 1/725 11/18722 0.352447152801959 0.552941695312018 NF1 1 GO:0051081 nuclear membrane disassembly 1/725 11/18722 0.352447152801959 0.552941695312018 NEK6 1 GO:0051573 negative regulation of histone H3-K9 methylation 1/725 11/18722 0.352447152801959 0.552941695312018 DNMT1 1 GO:0051610 serotonin uptake 1/725 11/18722 0.352447152801959 0.552941695312018 SLC6A4 1 GO:0051798 positive regulation of hair follicle development 1/725 11/18722 0.352447152801959 0.552941695312018 NUMA1 1 GO:0060174 limb bud formation 1/725 11/18722 0.352447152801959 0.552941695312018 SOX4 1 GO:0060312 regulation of blood vessel remodeling 1/725 11/18722 0.352447152801959 0.552941695312018 TMBIM1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/725 11/18722 0.352447152801959 0.552941695312018 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/725 11/18722 0.352447152801959 0.552941695312018 GLI3 1 GO:0060742 epithelial cell differentiation involved in prostate gland development 1/725 11/18722 0.352447152801959 0.552941695312018 PSAP 1 GO:0060746 parental behavior 1/725 11/18722 0.352447152801959 0.552941695312018 ZFX 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/725 11/18722 0.352447152801959 0.552941695312018 SERPINF1 1 GO:0060837 blood vessel endothelial cell differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 RBPJ 1 GO:0060900 embryonic camera-type eye formation 1/725 11/18722 0.352447152801959 0.552941695312018 TFAP2A 1 GO:0061029 eyelid development in camera-type eye 1/725 11/18722 0.352447152801959 0.552941695312018 TFAP2A 1 GO:0061635 regulation of protein complex stability 1/725 11/18722 0.352447152801959 0.552941695312018 HSPA8 1 GO:0070327 thyroid hormone transport 1/725 11/18722 0.352447152801959 0.552941695312018 SLC7A5 1 GO:0070417 cellular response to cold 1/725 11/18722 0.352447152801959 0.552941695312018 SLC9A1 1 GO:0070933 histone H4 deacetylation 1/725 11/18722 0.352447152801959 0.552941695312018 RCOR1 1 GO:0071492 cellular response to UV-A 1/725 11/18722 0.352447152801959 0.552941695312018 OPN3 1 GO:0071609 chemokine (C-C motif) ligand 5 production 1/725 11/18722 0.352447152801959 0.552941695312018 ARG2 1 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 1/725 11/18722 0.352447152801959 0.552941695312018 ARG2 1 GO:0071679 commissural neuron axon guidance 1/725 11/18722 0.352447152801959 0.552941695312018 DAG1 1 GO:0071888 macrophage apoptotic process 1/725 11/18722 0.352447152801959 0.552941695312018 CTSL 1 GO:0072497 mesenchymal stem cell differentiation 1/725 11/18722 0.352447152801959 0.552941695312018 KRT18 1 GO:0075294 positive regulation by symbiont of entry into host 1/725 11/18722 0.352447152801959 0.552941695312018 P4HB 1 GO:0086016 AV node cell action potential 1/725 11/18722 0.352447152801959 0.552941695312018 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/725 11/18722 0.352447152801959 0.552941695312018 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/725 11/18722 0.352447152801959 0.552941695312018 GJA5 1 GO:0090084 negative regulation of inclusion body assembly 1/725 11/18722 0.352447152801959 0.552941695312018 HSPA1A 1 GO:0090219 negative regulation of lipid kinase activity 1/725 11/18722 0.352447152801959 0.552941695312018 PIP4K2A 1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/725 11/18722 0.352447152801959 0.552941695312018 SLC35B4 1 GO:0097050 type B pancreatic cell apoptotic process 1/725 11/18722 0.352447152801959 0.552941695312018 SRSF6 1 GO:0097354 prenylation 1/725 11/18722 0.352447152801959 0.552941695312018 CHML 1 GO:0097384 cellular lipid biosynthetic process 1/725 11/18722 0.352447152801959 0.552941695312018 CHPT1 1 GO:0097494 regulation of vesicle size 1/725 11/18722 0.352447152801959 0.552941695312018 RAB11A 1 GO:0098792 xenophagy 1/725 11/18722 0.352447152801959 0.552941695312018 RIPK2 1 GO:0099022 vesicle tethering 1/725 11/18722 0.352447152801959 0.552941695312018 TRIP11 1 GO:0106049 regulation of cellular response to osmotic stress 1/725 11/18722 0.352447152801959 0.552941695312018 EFHD1 1 GO:0140042 lipid droplet formation 1/725 11/18722 0.352447152801959 0.552941695312018 CDS1 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/725 11/18722 0.352447152801959 0.552941695312018 ATRX 1 GO:1900222 negative regulation of amyloid-beta clearance 1/725 11/18722 0.352447152801959 0.552941695312018 LRPAP1 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/725 11/18722 0.352447152801959 0.552941695312018 N4BP2L2 1 GO:1902065 response to L-glutamate 1/725 11/18722 0.352447152801959 0.552941695312018 UFL1 1 GO:1902188 positive regulation of viral release from host cell 1/725 11/18722 0.352447152801959 0.552941695312018 DDB1 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/725 11/18722 0.352447152801959 0.552941695312018 BMP7 1 GO:1902667 regulation of axon guidance 1/725 11/18722 0.352447152801959 0.552941695312018 MYCBP2 1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1/725 11/18722 0.352447152801959 0.552941695312018 HSPA1A 1 GO:1903299 regulation of hexokinase activity 1/725 11/18722 0.352447152801959 0.552941695312018 RANBP2 1 GO:1904181 positive regulation of membrane depolarization 1/725 11/18722 0.352447152801959 0.552941695312018 PARP1 1 GO:1904321 response to forskolin 1/725 11/18722 0.352447152801959 0.552941695312018 FDX1 1 GO:1904322 cellular response to forskolin 1/725 11/18722 0.352447152801959 0.552941695312018 FDX1 1 GO:1905050 positive regulation of metallopeptidase activity 1/725 11/18722 0.352447152801959 0.552941695312018 CLDN4 1 GO:1905150 regulation of voltage-gated sodium channel activity 1/725 11/18722 0.352447152801959 0.552941695312018 KIF5B 1 GO:1905522 negative regulation of macrophage migration 1/725 11/18722 0.352447152801959 0.552941695312018 MIF 1 GO:1905668 positive regulation of protein localization to endosome 1/725 11/18722 0.352447152801959 0.552941695312018 EZR 1 GO:2000392 regulation of lamellipodium morphogenesis 1/725 11/18722 0.352447152801959 0.552941695312018 KANK1 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/725 11/18722 0.352447152801959 0.552941695312018 PKIB 1 GO:2000615 regulation of histone H3-K9 acetylation 1/725 11/18722 0.352447152801959 0.552941695312018 ZNF451 1 GO:2000644 regulation of receptor catabolic process 1/725 11/18722 0.352447152801959 0.552941695312018 MYLIP 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/725 11/18722 0.352447152801959 0.552941695312018 BMP7 1 GO:0071219 cellular response to molecule of bacterial origin 10/725 221/18722 0.353038677744434 0.552959271143766 PDCD4/RHOA/PDE4B/CEBPB/PABPN1/CD55/SASH1/RIPK2/HMGB1/SERPINE1 10 GO:0030431 sleep 2/725 32/18722 0.353221960931844 0.552959271143766 FOS/ADRB1 2 GO:0045684 positive regulation of epidermis development 2/725 32/18722 0.353221960931844 0.552959271143766 NCOA3/NUMA1 2 GO:0045879 negative regulation of smoothened signaling pathway 2/725 32/18722 0.353221960931844 0.552959271143766 GLI3/GPC3 2 GO:0046475 glycerophospholipid catabolic process 2/725 32/18722 0.353221960931844 0.552959271143766 PRDX6/GPCPD1 2 GO:0090022 regulation of neutrophil chemotaxis 2/725 32/18722 0.353221960931844 0.552959271143766 JAM3/RAC1 2 GO:1903955 positive regulation of protein targeting to mitochondrion 2/725 32/18722 0.353221960931844 0.552959271143766 HUWE1/UBE2D3 2 GO:0007204 positive regulation of cytosolic calcium ion concentration 14/725 319/18722 0.354162890305719 0.554261096313581 CAV1/LRP1/ITGAV/GJA1/CALM1/BCL2/CD55/C1QTNF1/ERO1A/DDIT3/HMGB1/SRI/GSTO1/CYBA 14 GO:0055007 cardiac muscle cell differentiation 6/725 125/18722 0.355387978956399 0.556006686830242 ITGB1/TBX3/ISL1/RBPJ/PLEC/SLC9A1 6 GO:0032368 regulation of lipid transport 7/725 149/18722 0.355869752764308 0.556588638309867 CAV1/LRP1/ITGAV/DBI/C1QTNF1/KDM5B/CYP19A1 7 GO:0022411 cellular component disassembly 19/725 443/18722 0.35663761256876 0.557617537973795 LRP1/LAMC1/KIF5B/HSPA8/CALM1/TRIOBP/BNIP3L/CTSV/DICER1/CFL1/UFL1/UBA5/HUWE1/UVRAG/NEK6/EIF5A/CCSAP/MAP1LC3B/CAPZB 19 GO:0030500 regulation of bone mineralization 4/725 78/18722 0.357416958876982 0.558491542708823 ATP2B1/FBN2/BMP7/TFAP2A 4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 4/725 78/18722 0.357416958876982 0.558491542708823 SERPINB9/DHCR24/HERPUD1/MDM2 4 GO:0000768 syncytium formation by plasma membrane fusion 3/725 55/18722 0.359123418120555 0.560812263232622 ADAM12/GDF15/CFLAR 3 GO:0140253 cell-cell fusion 3/725 55/18722 0.359123418120555 0.560812263232622 ADAM12/GDF15/CFLAR 3 GO:1904063 negative regulation of cation transmembrane transport 5/725 102/18722 0.361106212446039 0.56373495253741 C4orf3/CAV1/CALM1/SRI/GSTO1 5 GO:0032102 negative regulation of response to external stimulus 18/725 420/18722 0.363263228849515 0.564358709939509 SERPINB9/MIF/SEMA6D/SEMA6A/DUSP1/GJA1/ISL1/GRN/RPS19/ASH1L/NUCB2/PHLDB2/C1QTNF1/SERPINF1/SEMA4C/SERPINB2/SERPINE1/ARG2 18 GO:0002274 myeloid leukocyte activation 10/725 223/18722 0.36340298007008 0.564358709939509 MIF/APP/JUND/HSPD1/CTSC/DHRS2/RBPJ/GRN/VAMP2/HMGB1 10 GO:0050772 positive regulation of axonogenesis 4/725 79/18722 0.366282271703603 0.564358709939509 LRP1/MACF1/GOLGA4/RAB11A 4 GO:0051279 regulation of release of sequestered calcium ion into cytosol 4/725 79/18722 0.366282271703603 0.564358709939509 CALM1/SRI/GSTO1/CYBA 4 GO:0050954 sensory perception of mechanical stimulus 8/725 175/18722 0.36719836094103 0.564358709939509 LRP2/TRIOBP/TBL1X/SLC52A3/USP53/NIPBL/TFAP2A/DDIT3 8 GO:0001975 response to amphetamine 2/725 33/18722 0.367341933250031 0.564358709939509 CALM1/RANBP2 2 GO:0003382 epithelial cell morphogenesis 2/725 33/18722 0.367341933250031 0.564358709939509 MET/FLNB 2 GO:0006336 DNA replication-independent nucleosome assembly 2/725 33/18722 0.367341933250031 0.564358709939509 NASP/ATRX 2 GO:0006482 protein demethylation 2/725 33/18722 0.367341933250031 0.564358709939509 KDM5A/KDM5B 2 GO:0008214 protein dealkylation 2/725 33/18722 0.367341933250031 0.564358709939509 KDM5A/KDM5B 2 GO:0009156 ribonucleoside monophosphate biosynthetic process 2/725 33/18722 0.367341933250031 0.564358709939509 UPP1/RFK 2 GO:0010737 protein kinase A signaling 2/725 33/18722 0.367341933250031 0.564358709939509 MIF/EZR 2 GO:0010984 regulation of lipoprotein particle clearance 2/725 33/18722 0.367341933250031 0.564358709939509 LRPAP1/MYLIP 2 GO:0033198 response to ATP 2/725 33/18722 0.367341933250031 0.564358709939509 HSPD1/HSP90B1 2 GO:0036336 dendritic cell migration 2/725 33/18722 0.367341933250031 0.564358709939509 CDC42/HMGB1 2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 2/725 33/18722 0.367341933250031 0.564358709939509 CDC42/FLT1 2 GO:0050901 leukocyte tethering or rolling 2/725 33/18722 0.367341933250031 0.564358709939509 ITGB1/ROCK1 2 GO:0071295 cellular response to vitamin 2/725 33/18722 0.367341933250031 0.564358709939509 ATP2B1/MDM2 2 GO:1900181 negative regulation of protein localization to nucleus 2/725 33/18722 0.367341933250031 0.564358709939509 MAGED1/LATS2 2 GO:1901099 negative regulation of signal transduction in absence of ligand 2/725 33/18722 0.367341933250031 0.564358709939509 BCL2/HSPA1A 2 GO:1901976 regulation of cell cycle checkpoint 2/725 33/18722 0.367341933250031 0.564358709939509 DUSP1/PPP1R10 2 GO:1902275 regulation of chromatin organization 2/725 33/18722 0.367341933250031 0.564358709939509 MPHOSPH8/DNMT1 2 GO:1902692 regulation of neuroblast proliferation 2/725 33/18722 0.367341933250031 0.564358709939509 GLI3/NF1 2 GO:1902992 negative regulation of amyloid precursor protein catabolic process 2/725 33/18722 0.367341933250031 0.564358709939509 ROCK1/RTN4 2 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/725 33/18722 0.367341933250031 0.564358709939509 EGFR/CDKN1A 2 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/725 33/18722 0.367341933250031 0.564358709939509 BCL2/HSPA1A 2 GO:0032984 protein-containing complex disassembly 10/725 224/18722 0.368599467840807 0.564358709939509 KIF5B/HSPA8/CALM1/TRIOBP/CFL1/UVRAG/EIF5A/CCSAP/MAP1LC3B/CAPZB 10 GO:0019395 fatty acid oxidation 5/725 103/18722 0.368842554654257 0.564358709939509 SLC27A2/CROT/ADH5/HADHA/ECHDC2 5 GO:0030004 cellular monovalent inorganic cation homeostasis 5/725 103/18722 0.368842554654257 0.564358709939509 ATP6V0E1/GRN/BCL2/SLC9A1/ATP6AP2 5 GO:1905037 autophagosome organization 5/725 103/18722 0.368842554654257 0.564358709939509 RALB/TMEM41B/PIP4K2A/RAB1A/MAP1LC3B 5 GO:0002711 positive regulation of T cell mediated immunity 3/725 56/18722 0.369772083710781 0.564358709939509 HSPD1/CD55/B2M 3 GO:0015800 acidic amino acid transport 3/725 56/18722 0.369772083710781 0.564358709939509 ITGB1/GJA1/ARL6IP5 3 GO:0042733 embryonic digit morphogenesis 3/725 56/18722 0.369772083710781 0.564358709939509 TBX3/GLI3/LRP5 3 GO:0048255 mRNA stabilization 3/725 56/18722 0.369772083710781 0.564358709939509 FUS/LARP1/YBX1 3 GO:0051784 negative regulation of nuclear division 3/725 56/18722 0.369772083710781 0.564358709939509 DUSP1/BMP7/CENPF 3 GO:0072522 purine-containing compound biosynthetic process 9/725 200/18722 0.370941685183215 0.564358709939509 SLC26A2/ALDOA/ACSS1/PARP1/PNP/TMSB4X/ENO1/MPC2/AK3 9 GO:0006869 lipid transport 17/725 398/18722 0.374102187140604 0.564358709939509 PLIN2/CAV1/LRP1/ITGAV/KCNN4/ANXA1/SLC27A2/CROT/ABCB1/PSAP/DBI/SYT7/C1QTNF1/PIP4K2A/KDM5B/CYP19A1/ARL8B 17 GO:0016125 sterol metabolic process 7/725 152/18722 0.374924158186434 0.564358709939509 APP/CYP11A1/DHCR24/LRP5/CAT/CYP19A1/FDX1 7 GO:0021766 hippocampus development 4/725 80/18722 0.375141139842214 0.564358709939509 KIF5B/BTG2/GLI3/HSD3B1 4 GO:1901264 carbohydrate derivative transport 4/725 80/18722 0.375141139842214 0.564358709939509 GJA1/PSAP/SLC29A3/SLC35B4 4 GO:0014896 muscle hypertrophy 5/725 104/18722 0.376580223130223 0.564358709939509 PARP1/IL6ST/ROCK1/SLC9A1/CYBA 5 GO:0032963 collagen metabolic process 5/725 104/18722 0.376580223130223 0.564358709939509 ITGB1/CTSL/SUCO/SERPINH1/ENG 5 GO:1901890 positive regulation of cell junction assembly 5/725 104/18722 0.376580223130223 0.564358709939509 CAV1/DLG5/ROCK1/IQGAP1/RAC1 5 GO:0000012 single strand break repair 1/725 12/18722 0.377538051963873 0.564358709939509 PARP1 1 GO:0000491 small nucleolar ribonucleoprotein complex assembly 1/725 12/18722 0.377538051963873 0.564358709939509 SNU13 1 GO:0002024 diet induced thermogenesis 1/725 12/18722 0.377538051963873 0.564358709939509 ADRB1 1 GO:0002674 negative regulation of acute inflammatory response 1/725 12/18722 0.377538051963873 0.564358709939509 ASH1L 1 GO:0002903 negative regulation of B cell apoptotic process 1/725 12/18722 0.377538051963873 0.564358709939509 SLC39A10 1 GO:0003207 cardiac chamber formation 1/725 12/18722 0.377538051963873 0.564358709939509 SOX4 1 GO:0003306 Wnt signaling pathway involved in heart development 1/725 12/18722 0.377538051963873 0.564358709939509 RBPJ 1 GO:0006285 base-excision repair, AP site formation 1/725 12/18722 0.377538051963873 0.564358709939509 TDG 1 GO:0007320 insemination 1/725 12/18722 0.377538051963873 0.564358709939509 SLC6A4 1 GO:0007614 short-term memory 1/725 12/18722 0.377538051963873 0.564358709939509 SERPINF1 1 GO:0009086 methionine biosynthetic process 1/725 12/18722 0.377538051963873 0.564358709939509 MTR 1 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 UPP1 1 GO:0010454 negative regulation of cell fate commitment 1/725 12/18722 0.377538051963873 0.564358709939509 HES1 1 GO:0010459 negative regulation of heart rate 1/725 12/18722 0.377538051963873 0.564358709939509 SRI 1 GO:0010587 miRNA catabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 KCNQ1OT1 1 GO:0010826 negative regulation of centrosome duplication 1/725 12/18722 0.377538051963873 0.564358709939509 NPM1 1 GO:0014889 muscle atrophy 1/725 12/18722 0.377538051963873 0.564358709939509 CFLAR 1 GO:0015780 nucleotide-sugar transmembrane transport 1/725 12/18722 0.377538051963873 0.564358709939509 SLC35B4 1 GO:0016554 cytidine to uridine editing 1/725 12/18722 0.377538051963873 0.564358709939509 RBM47 1 GO:0019627 urea metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 ARG2 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/725 12/18722 0.377538051963873 0.564358709939509 SLC6A4 1 GO:0030202 heparin metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 GLCE 1 GO:0030397 membrane disassembly 1/725 12/18722 0.377538051963873 0.564358709939509 NEK6 1 GO:0032096 negative regulation of response to food 1/725 12/18722 0.377538051963873 0.564358709939509 NUCB2 1 GO:0032099 negative regulation of appetite 1/725 12/18722 0.377538051963873 0.564358709939509 NUCB2 1 GO:0032105 negative regulation of response to extracellular stimulus 1/725 12/18722 0.377538051963873 0.564358709939509 NUCB2 1 GO:0032108 negative regulation of response to nutrient levels 1/725 12/18722 0.377538051963873 0.564358709939509 NUCB2 1 GO:0032536 regulation of cell projection size 1/725 12/18722 0.377538051963873 0.564358709939509 EZR 1 GO:0032908 regulation of transforming growth factor beta1 production 1/725 12/18722 0.377538051963873 0.564358709939509 ATP6AP2 1 GO:0032926 negative regulation of activin receptor signaling pathway 1/725 12/18722 0.377538051963873 0.564358709939509 FSTL3 1 GO:0033079 immature T cell proliferation 1/725 12/18722 0.377538051963873 0.564358709939509 RIPK2 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/725 12/18722 0.377538051963873 0.564358709939509 CROT 1 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway 1/725 12/18722 0.377538051963873 0.564358709939509 HMGB1 1 GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/725 12/18722 0.377538051963873 0.564358709939509 DNMT1 1 GO:0035112 genitalia morphogenesis 1/725 12/18722 0.377538051963873 0.564358709939509 NIPBL 1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 1/725 12/18722 0.377538051963873 0.564358709939509 COL4A2 1 GO:0042118 endothelial cell activation 1/725 12/18722 0.377538051963873 0.564358709939509 PPIA 1 GO:0042762 regulation of sulfur metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 NFE2L2 1 GO:0043248 proteasome assembly 1/725 12/18722 0.377538051963873 0.564358709939509 POMP 1 GO:0043380 regulation of memory T cell differentiation 1/725 12/18722 0.377538051963873 0.564358709939509 CD46 1 GO:0043383 negative T cell selection 1/725 12/18722 0.377538051963873 0.564358709939509 GLI3 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 HMGB1 1 GO:0043476 pigment accumulation 1/725 12/18722 0.377538051963873 0.564358709939509 CD63 1 GO:0043482 cellular pigment accumulation 1/725 12/18722 0.377538051963873 0.564358709939509 CD63 1 GO:0043696 dedifferentiation 1/725 12/18722 0.377538051963873 0.564358709939509 NCOA3 1 GO:0043697 cell dedifferentiation 1/725 12/18722 0.377538051963873 0.564358709939509 NCOA3 1 GO:0045117 azole transmembrane transport 1/725 12/18722 0.377538051963873 0.564358709939509 SLC19A3 1 GO:0046051 UTP metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 AK3 1 GO:0046185 aldehyde catabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 ADH5 1 GO:0046541 saliva secretion 1/725 12/18722 0.377538051963873 0.564358709939509 KCNN4 1 GO:0046606 negative regulation of centrosome cycle 1/725 12/18722 0.377538051963873 0.564358709939509 NPM1 1 GO:0046831 regulation of RNA export from nucleus 1/725 12/18722 0.377538051963873 0.564358709939509 SETD2 1 GO:0048742 regulation of skeletal muscle fiber development 1/725 12/18722 0.377538051963873 0.564358709939509 BCL2 1 GO:0048934 peripheral nervous system neuron differentiation 1/725 12/18722 0.377538051963873 0.564358709939509 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/725 12/18722 0.377538051963873 0.564358709939509 ISL1 1 GO:0051001 negative regulation of nitric-oxide synthase activity 1/725 12/18722 0.377538051963873 0.564358709939509 CAV1 1 GO:0051340 regulation of ligase activity 1/725 12/18722 0.377538051963873 0.564358709939509 TMSB4X 1 GO:0051639 actin filament network formation 1/725 12/18722 0.377538051963873 0.564358709939509 COBL 1 GO:0060009 Sertoli cell development 1/725 12/18722 0.377538051963873 0.564358709939509 ATRX 1 GO:0060123 regulation of growth hormone secretion 1/725 12/18722 0.377538051963873 0.564358709939509 SERP1 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/725 12/18722 0.377538051963873 0.564358709939509 LRP1 1 GO:0060442 branching involved in prostate gland morphogenesis 1/725 12/18722 0.377538051963873 0.564358709939509 BMP7 1 GO:0060453 regulation of gastric acid secretion 1/725 12/18722 0.377538051963873 0.564358709939509 SGK1 1 GO:0060601 lateral sprouting from an epithelium 1/725 12/18722 0.377538051963873 0.564358709939509 BMP7 1 GO:0060788 ectodermal placode formation 1/725 12/18722 0.377538051963873 0.564358709939509 TBX3 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/725 12/18722 0.377538051963873 0.564358709939509 GLI3 1 GO:0061430 bone trabecula morphogenesis 1/725 12/18722 0.377538051963873 0.564358709939509 FBN2 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/725 12/18722 0.377538051963873 0.564358709939509 ENO1 1 GO:0070170 regulation of tooth mineralization 1/725 12/18722 0.377538051963873 0.564358709939509 TFAP2A 1 GO:0070213 protein auto-ADP-ribosylation 1/725 12/18722 0.377538051963873 0.564358709939509 PARP1 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/725 12/18722 0.377538051963873 0.564358709939509 BRD4 1 GO:0071107 response to parathyroid hormone 1/725 12/18722 0.377538051963873 0.564358709939509 GJA1 1 GO:0071257 cellular response to electrical stimulus 1/725 12/18722 0.377538051963873 0.564358709939509 SLC9A1 1 GO:0071468 cellular response to acidic pH 1/725 12/18722 0.377538051963873 0.564358709939509 SLC9A1 1 GO:0071697 ectodermal placode morphogenesis 1/725 12/18722 0.377538051963873 0.564358709939509 TBX3 1 GO:0071941 nitrogen cycle metabolic process 1/725 12/18722 0.377538051963873 0.564358709939509 ARG2 1 GO:0072015 glomerular visceral epithelial cell development 1/725 12/18722 0.377538051963873 0.564358709939509 IQGAP1 1 GO:0072376 protein activation cascade 1/725 12/18722 0.377538051963873 0.564358709939509 FBLN1 1 GO:0072584 caveolin-mediated endocytosis 1/725 12/18722 0.377538051963873 0.564358709939509 CAV1 1 GO:0072683 T cell extravasation 1/725 12/18722 0.377538051963873 0.564358709939509 CD99 1 GO:0072711 cellular response to hydroxyurea 1/725 12/18722 0.377538051963873 0.564358709939509 ATRX 1 GO:0086067 AV node cell to bundle of His cell communication 1/725 12/18722 0.377538051963873 0.564358709939509 GJA5 1 GO:0090331 negative regulation of platelet aggregation 1/725 12/18722 0.377538051963873 0.564358709939509 C1QTNF1 1 GO:0090677 reversible differentiation 1/725 12/18722 0.377538051963873 0.564358709939509 DNMT1 1 GO:0097152 mesenchymal cell apoptotic process 1/725 12/18722 0.377538051963873 0.564358709939509 BMP7 1 GO:0150065 regulation of deacetylase activity 1/725 12/18722 0.377538051963873 0.564358709939509 KDM5A 1 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 1/725 12/18722 0.377538051963873 0.564358709939509 MET 1 GO:1901503 ether biosynthetic process 1/725 12/18722 0.377538051963873 0.564358709939509 CHPT1 1 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 1/725 12/18722 0.377538051963873 0.564358709939509 C4orf3 1 GO:1902563 regulation of neutrophil activation 1/725 12/18722 0.377538051963873 0.564358709939509 GRN 1 GO:1902950 regulation of dendritic spine maintenance 1/725 12/18722 0.377538051963873 0.564358709939509 HOMER1 1 GO:1904667 negative regulation of ubiquitin protein ligase activity 1/725 12/18722 0.377538051963873 0.564358709939509 RPS20 1 GO:1904748 regulation of apoptotic process involved in development 1/725 12/18722 0.377538051963873 0.564358709939509 BMP7 1 GO:1905205 positive regulation of connective tissue replacement 1/725 12/18722 0.377538051963873 0.564358709939509 ROCK1 1 GO:1905245 regulation of aspartic-type peptidase activity 1/725 12/18722 0.377538051963873 0.564358709939509 GRN 1 GO:1905666 regulation of protein localization to endosome 1/725 12/18722 0.377538051963873 0.564358709939509 EZR 1 GO:2000009 negative regulation of protein localization to cell surface 1/725 12/18722 0.377538051963873 0.564358709939509 GOPC 1 GO:2000035 regulation of stem cell division 1/725 12/18722 0.377538051963873 0.564358709939509 NCOA3 1 GO:2000105 positive regulation of DNA-dependent DNA replication 1/725 12/18722 0.377538051963873 0.564358709939509 ATRX 1 GO:2000303 regulation of ceramide biosynthetic process 1/725 12/18722 0.377538051963873 0.564358709939509 ORMDL1 1 GO:2001204 regulation of osteoclast development 1/725 12/18722 0.377538051963873 0.564358709939509 FBN1 1 GO:0006949 syncytium formation 3/725 57/18722 0.380387999259012 0.566367317856115 ADAM12/GDF15/CFLAR 3 GO:0016447 somatic recombination of immunoglobulin gene segments 3/725 57/18722 0.380387999259012 0.566367317856115 TFRC/HSPD1/PRKDC 3 GO:0051155 positive regulation of striated muscle cell differentiation 3/725 57/18722 0.380387999259012 0.566367317856115 BCL2/HOPX/MORF4L2 3 GO:0051205 protein insertion into membrane 3/725 57/18722 0.380387999259012 0.566367317856115 EGFR/NMT1/CCDC47 3 GO:0060042 retina morphogenesis in camera-type eye 3/725 57/18722 0.380387999259012 0.566367317856115 LRP5/TFAP2A/RDH13 3 GO:0060760 positive regulation of response to cytokine stimulus 3/725 57/18722 0.380387999259012 0.566367317856115 TRIM44/HSPA1A/RIPK2 3 GO:0120254 olefinic compound metabolic process 7/725 153/18722 0.381288664746104 0.566367317856115 CYP2J2/CYP11A1/AKR1B1/RDH10/GPX4/HSD17B1/RDH13 7 GO:0000038 very long-chain fatty acid metabolic process 2/725 34/18722 0.381339841357846 0.566367317856115 HACD3/SLC27A2 2 GO:0001662 behavioral fear response 2/725 34/18722 0.381339841357846 0.566367317856115 GJA1/BCL2 2 GO:0009649 entrainment of circadian clock 2/725 34/18722 0.381339841357846 0.566367317856115 PHLPP1/GNAQ 2 GO:0032770 positive regulation of monooxygenase activity 2/725 34/18722 0.381339841357846 0.566367317856115 CALM1/PIK3CB 2 GO:0034724 DNA replication-independent nucleosome organization 2/725 34/18722 0.381339841357846 0.566367317856115 NASP/ATRX 2 GO:0035137 hindlimb morphogenesis 2/725 34/18722 0.381339841357846 0.566367317856115 TBX3/GPC3 2 GO:0044319 wound healing, spreading of cells 2/725 34/18722 0.381339841357846 0.566367317856115 RHOA/PHLDB2 2 GO:0048854 brain morphogenesis 2/725 34/18722 0.381339841357846 0.566367317856115 NF1/SLC6A4 2 GO:0051973 positive regulation of telomerase activity 2/725 34/18722 0.381339841357846 0.566367317856115 MAP3K4/PKIB 2 GO:0070884 regulation of calcineurin-NFAT signaling cascade 2/725 34/18722 0.381339841357846 0.566367317856115 NFAT5/SLC9A1 2 GO:0086019 cell-cell signaling involved in cardiac conduction 2/725 34/18722 0.381339841357846 0.566367317856115 GJA1/GJA5 2 GO:0090075 relaxation of muscle 2/725 34/18722 0.381339841357846 0.566367317856115 PDE4B/SRI 2 GO:0090505 epiboly involved in wound healing 2/725 34/18722 0.381339841357846 0.566367317856115 RHOA/PHLDB2 2 GO:1904893 negative regulation of receptor signaling pathway via STAT 2/725 34/18722 0.381339841357846 0.566367317856115 CAV1/SOCS1 2 GO:2000352 negative regulation of endothelial cell apoptotic process 2/725 34/18722 0.381339841357846 0.566367317856115 NFE2L2/SERPINE1 2 GO:0000819 sister chromatid segregation 9/725 202/18722 0.381990780251441 0.567167915962084 DUSP1/ATRX/NIPBL/KPNB1/STAG1/NEK6/NUMA1/RAB11A/CENPF 9 GO:0021954 central nervous system neuron development 4/725 81/18722 0.383989183063263 0.569619531368806 NRP2/BTG2/MYCBP2/C12orf57 4 GO:0046209 nitric oxide metabolic process 4/725 81/18722 0.383989183063263 0.569619531368806 DYNLL1/CAV1/RAC1/ARG2 4 GO:2000106 regulation of leukocyte apoptotic process 4/725 81/18722 0.383989183063263 0.569619531368806 SLC39A10/ANXA1/PIK3CB/ARG2 4 GO:0046777 protein autophosphorylation 10/725 227/18722 0.384234626697282 0.569619531368806 CAV1/AAK1/EPHB4/EGFR/CALM1/RAD50/IQGAP1/NEK6/ENG/FLT1 10 GO:0098657 import into cell 10/725 227/18722 0.384234626697282 0.569619531368806 ITGB1/LRP2/SLC39A10/SLC38A1/SLC27A2/SLC6A4/ARL6IP5/SLC9A1/DLG1/SLC7A5 10 GO:0000041 transition metal ion transport 5/725 105/18722 0.384316195952124 0.569619531368806 TFRC/SLC39A10/FTH1/CLTC/B2M 5 GO:0044282 small molecule catabolic process 16/725 376/18722 0.385563750192588 0.571301563790187 TPI1/GLDC/UPP1/SLC27A2/PNP/CROT/LRP5/LPIN2/ENO1/GLUL/FUT8/NAGK/ADH5/HADHA/ECHDC2/ARG2 16 GO:0051168 nuclear export 7/725 154/18722 0.387656808642317 0.573684020137207 NPM1/PTPN14/PABPN1/HNRNPA1/MDM2/UPF2/SETD2 7 GO:0002831 regulation of response to biotic stimulus 14/725 327/18722 0.388826313038106 0.573684020137207 SERPINB9/HSPD1/PRKDC/GRN/RPS19/SOCS1/TRIM44/PUM1/CD55/SASH1/RIPK2/HMGB1/ARG2/CYBA 14 GO:0010559 regulation of glycoprotein biosynthetic process 3/725 58/18722 0.390964370437806 0.573684020137207 ITM2B/BCL2/AGO2 3 GO:0043506 regulation of JUN kinase activity 3/725 58/18722 0.390964370437806 0.573684020137207 MAP3K4/PDCD4/SASH1 3 GO:0002062 chondrocyte differentiation 5/725 106/18722 0.392047511516107 0.573684020137207 GLG1/EFEMP1/GLI3/TRIP11/SERPINH1 5 GO:0019882 antigen processing and presentation 5/725 106/18722 0.392047511516107 0.573684020137207 CTSL/CTSV/LGMN/ARL8B/B2M 5 GO:0046822 regulation of nucleocytoplasmic transport 5/725 106/18722 0.392047511516107 0.573684020137207 CDH1/GLI3/PTPN14/MDM2/SETD2 5 GO:2001057 reactive nitrogen species metabolic process 4/725 82/18722 0.392822146861161 0.573684020137207 DYNLL1/CAV1/RAC1/ARG2 4 GO:0006066 alcohol metabolic process 15/725 353/18722 0.393513845007913 0.573684020137207 TPI1/APP/ACSS1/CYP11A1/PLPP3/AKR1B1/DHCR24/ISYNA1/IDH1/LRP5/RDH10/CAT/ADH5/RDH13/FDX1 15 GO:0000460 maturation of 5.8S rRNA 2/725 35/18722 0.395203967829109 0.573684020137207 RPS21/PRKDC 2 GO:0002209 behavioral defense response 2/725 35/18722 0.395203967829109 0.573684020137207 GJA1/BCL2 2 GO:0006084 acetyl-CoA metabolic process 2/725 35/18722 0.395203967829109 0.573684020137207 ACSS1/MPC2 2 GO:0006471 protein ADP-ribosylation 2/725 35/18722 0.395203967829109 0.573684020137207 PARP1/ARF4 2 GO:0006739 NADP metabolic process 2/725 35/18722 0.395203967829109 0.573684020137207 IDH1/RPIA 2 GO:0007020 microtubule nucleation 2/725 35/18722 0.395203967829109 0.573684020137207 AKAP9/HSPA1A 2 GO:0009119 ribonucleoside metabolic process 2/725 35/18722 0.395203967829109 0.573684020137207 UPP1/PNP 2 GO:0015695 organic cation transport 2/725 35/18722 0.395203967829109 0.573684020137207 SLC19A3/ATP13A3 2 GO:0018149 peptide cross-linking 2/725 35/18722 0.395203967829109 0.573684020137207 ANXA1/BGN 2 GO:0021955 central nervous system neuron axonogenesis 2/725 35/18722 0.395203967829109 0.573684020137207 MYCBP2/C12orf57 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/725 35/18722 0.395203967829109 0.573684020137207 EIF3H/SDCBP 2 GO:0033280 response to vitamin D 2/725 35/18722 0.395203967829109 0.573684020137207 ATP2B1/BMP7 2 GO:0039694 viral RNA genome replication 2/725 35/18722 0.395203967829109 0.573684020137207 MPHOSPH8/CDC42 2 GO:0043243 positive regulation of protein-containing complex disassembly 2/725 35/18722 0.395203967829109 0.573684020137207 UVRAG/EIF5A 2 GO:0045880 positive regulation of smoothened signaling pathway 2/725 35/18722 0.395203967829109 0.573684020137207 DLG5/GPC3 2 GO:0048821 erythrocyte development 2/725 35/18722 0.395203967829109 0.573684020137207 RPS6/FAM210B 2 GO:0071108 protein K48-linked deubiquitination 2/725 35/18722 0.395203967829109 0.573684020137207 USP27X/USP9X 2 GO:0090504 epiboly 2/725 35/18722 0.395203967829109 0.573684020137207 RHOA/PHLDB2 2 GO:0098810 neurotransmitter reuptake 2/725 35/18722 0.395203967829109 0.573684020137207 ITGB1/SLC6A4 2 GO:0106056 regulation of calcineurin-mediated signaling 2/725 35/18722 0.395203967829109 0.573684020137207 NFAT5/SLC9A1 2 GO:1905207 regulation of cardiocyte differentiation 2/725 35/18722 0.395203967829109 0.573684020137207 EGFR/DHX36 2 GO:2000403 positive regulation of lymphocyte migration 2/725 35/18722 0.395203967829109 0.573684020137207 APP/RHOA 2 GO:0009165 nucleotide biosynthetic process 11/725 254/18722 0.395850270709822 0.573684020137207 SLC26A2/ALDOA/ACSS1/UPP1/PARP1/PNP/TMSB4X/ENO1/MPC2/AK3/RFK 11 GO:0000018 regulation of DNA recombination 5/725 107/18722 0.399771270160001 0.573684020137207 TFRC/FUS/PARP1/RAD50/SETD2 5 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5/725 107/18722 0.399771270160001 0.573684020137207 TFRC/HSPD1/CD55/RIPK2/B2M 5 GO:0016197 endosomal transport 10/725 230/18722 0.399918159891245 0.573684020137207 LEPROTL1/SPAG9/TINAGL1/CLTC/ERC1/TMEM87A/RHOBTB3/SNX27/RAB11A/ARL8B 10 GO:0045333 cellular respiration 10/725 230/18722 0.399918159891245 0.573684020137207 IDH1/RHOA/OPN3/PLEC/COX6A1/CAT/UQCRH/CHCHD2/SDHA/CHCHD10 10 GO:0001836 release of cytochrome c from mitochondria 3/725 59/18722 0.401494719733253 0.573684020137207 JUN/PMAIP1/BCL2 3 GO:0006406 mRNA export from nucleus 3/725 59/18722 0.401494719733253 0.573684020137207 PABPN1/UPF2/SETD2 3 GO:0030042 actin filament depolymerization 3/725 59/18722 0.401494719733253 0.573684020137207 TRIOBP/CFL1/CAPZB 3 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 3/725 59/18722 0.401494719733253 0.573684020137207 SOCS1/CDC42/FLT1 3 GO:0046324 regulation of glucose import 3/725 59/18722 0.401494719733253 0.573684020137207 NFE2L2/OPN3/GPC3 3 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 3/725 59/18722 0.401494719733253 0.573684020137207 CAV1/SOCS1/CBLB 3 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 3/725 59/18722 0.401494719733253 0.573684020137207 PABPN1/UPF2/SETD2 3 GO:2000351 regulation of endothelial cell apoptotic process 3/725 59/18722 0.401494719733253 0.573684020137207 PDCD4/NFE2L2/SERPINE1 3 GO:0061053 somite development 4/725 83/18722 0.401635903869469 0.573684020137207 PRKDC/RBPJ/COBL/MIB1 4 GO:0001886 endothelial cell morphogenesis 1/725 13/18722 0.401658036588469 0.573684020137207 MET 1 GO:0002638 negative regulation of immunoglobulin production 1/725 13/18722 0.401658036588469 0.573684020137207 PRKDC 1 GO:0005513 detection of calcium ion 1/725 13/18722 0.401658036588469 0.573684020137207 CALM1 1 GO:0006995 cellular response to nitrogen starvation 1/725 13/18722 0.401658036588469 0.573684020137207 MAP1LC3B 1 GO:0007183 SMAD protein complex assembly 1/725 13/18722 0.401658036588469 0.573684020137207 PARP1 1 GO:0007494 midgut development 1/725 13/18722 0.401658036588469 0.573684020137207 EGFR 1 GO:0007512 adult heart development 1/725 13/18722 0.401658036588469 0.573684020137207 APELA 1 GO:0008298 intracellular mRNA localization 1/725 13/18722 0.401658036588469 0.573684020137207 DHX36 1 GO:0009437 carnitine metabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 CROT 1 GO:0009650 UV protection 1/725 13/18722 0.401658036588469 0.573684020137207 CAT 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/725 13/18722 0.401658036588469 0.573684020137207 ITGAV 1 GO:0014029 neural crest formation 1/725 13/18722 0.401658036588469 0.573684020137207 PDCD6 1 GO:0014842 regulation of skeletal muscle satellite cell proliferation 1/725 13/18722 0.401658036588469 0.573684020137207 CFLAR 1 GO:0015801 aromatic amino acid transport 1/725 13/18722 0.401658036588469 0.573684020137207 SLC7A5 1 GO:0015809 arginine transport 1/725 13/18722 0.401658036588469 0.573684020137207 SLC38A9 1 GO:0016024 CDP-diacylglycerol biosynthetic process 1/725 13/18722 0.401658036588469 0.573684020137207 CDS1 1 GO:0016056 rhodopsin mediated signaling pathway 1/725 13/18722 0.401658036588469 0.573684020137207 NMT1 1 GO:0016078 tRNA catabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 DICER1 1 GO:0016322 neuron remodeling 1/725 13/18722 0.401658036588469 0.573684020137207 APP 1 GO:0019336 phenol-containing compound catabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 MAOA 1 GO:0021514 ventral spinal cord interneuron differentiation 1/725 13/18722 0.401658036588469 0.573684020137207 GLI3 1 GO:0021984 adenohypophysis development 1/725 13/18722 0.401658036588469 0.573684020137207 HES1 1 GO:0030497 fatty acid elongation 1/725 13/18722 0.401658036588469 0.573684020137207 HACD3 1 GO:0031272 regulation of pseudopodium assembly 1/725 13/18722 0.401658036588469 0.573684020137207 CDC42 1 GO:0031274 positive regulation of pseudopodium assembly 1/725 13/18722 0.401658036588469 0.573684020137207 CDC42 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/725 13/18722 0.401658036588469 0.573684020137207 ANXA1 1 GO:0032042 mitochondrial DNA metabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 PARP1 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/725 13/18722 0.401658036588469 0.573684020137207 KIF5B 1 GO:0032252 secretory granule localization 1/725 13/18722 0.401658036588469 0.573684020137207 KIF5B 1 GO:0032352 positive regulation of hormone metabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 RDH10 1 GO:0032494 response to peptidoglycan 1/725 13/18722 0.401658036588469 0.573684020137207 RIPK2 1 GO:0032530 regulation of microvillus organization 1/725 13/18722 0.401658036588469 0.573684020137207 EZR 1 GO:0032905 transforming growth factor beta1 production 1/725 13/18722 0.401658036588469 0.573684020137207 ATP6AP2 1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 1/725 13/18722 0.401658036588469 0.573684020137207 BRD4 1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1/725 13/18722 0.401658036588469 0.573684020137207 PARP1 1 GO:0033262 regulation of nuclear cell cycle DNA replication 1/725 13/18722 0.401658036588469 0.573684020137207 ATRX 1 GO:0033689 negative regulation of osteoblast proliferation 1/725 13/18722 0.401658036588469 0.573684020137207 BCL2 1 GO:0034112 positive regulation of homotypic cell-cell adhesion 1/725 13/18722 0.401658036588469 0.573684020137207 IL6ST 1 GO:0034982 mitochondrial protein processing 1/725 13/18722 0.401658036588469 0.573684020137207 AFG3L2 1 GO:0035331 negative regulation of hippo signaling 1/725 13/18722 0.401658036588469 0.573684020137207 DLG5 1 GO:0042492 gamma-delta T cell differentiation 1/725 13/18722 0.401658036588469 0.573684020137207 SOX4 1 GO:0042541 hemoglobin biosynthetic process 1/725 13/18722 0.401658036588469 0.573684020137207 INHA 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/725 13/18722 0.401658036588469 0.573684020137207 HACD3 1 GO:0043379 memory T cell differentiation 1/725 13/18722 0.401658036588469 0.573684020137207 CD46 1 GO:0043562 cellular response to nitrogen levels 1/725 13/18722 0.401658036588469 0.573684020137207 MAP1LC3B 1 GO:0043970 histone H3-K9 acetylation 1/725 13/18722 0.401658036588469 0.573684020137207 ZNF451 1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 1/725 13/18722 0.401658036588469 0.573684020137207 NEURL1 1 GO:0046415 urate metabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 PNP 1 GO:0046689 response to mercury ion 1/725 13/18722 0.401658036588469 0.573684020137207 UBE2D3 1 GO:0048070 regulation of developmental pigmentation 1/725 13/18722 0.401658036588469 0.573684020137207 BCL2 1 GO:0048207 vesicle targeting, rough ER to cis-Golgi 1/725 13/18722 0.401658036588469 0.573684020137207 PDCD6 1 GO:0048208 COPII vesicle coating 1/725 13/18722 0.401658036588469 0.573684020137207 PDCD6 1 GO:0048820 hair follicle maturation 1/725 13/18722 0.401658036588469 0.573684020137207 RBPJ 1 GO:0051709 regulation of killing of cells of other organism 1/725 13/18722 0.401658036588469 0.573684020137207 SERPINB9 1 GO:0051956 negative regulation of amino acid transport 1/725 13/18722 0.401658036588469 0.573684020137207 ARL6IP5 1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 1/725 13/18722 0.401658036588469 0.573684020137207 CDC42 1 GO:0060670 branching involved in labyrinthine layer morphogenesis 1/725 13/18722 0.401658036588469 0.573684020137207 SPINT1 1 GO:0060707 trophoblast giant cell differentiation 1/725 13/18722 0.401658036588469 0.573684020137207 NR2F2 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/725 13/18722 0.401658036588469 0.573684020137207 ENO1 1 GO:0061744 motor behavior 1/725 13/18722 0.401658036588469 0.573684020137207 C12orf57 1 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 1/725 13/18722 0.401658036588469 0.573684020137207 HSPA1A 1 GO:0070914 UV-damage excision repair 1/725 13/18722 0.401658036588469 0.573684020137207 DDB1 1 GO:0071696 ectodermal placode development 1/725 13/18722 0.401658036588469 0.573684020137207 TBX3 1 GO:0071801 regulation of podosome assembly 1/725 13/18722 0.401658036588469 0.573684020137207 RHOA 1 GO:0072310 glomerular epithelial cell development 1/725 13/18722 0.401658036588469 0.573684020137207 IQGAP1 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/725 13/18722 0.401658036588469 0.573684020137207 HOOK3 1 GO:0072672 neutrophil extravasation 1/725 13/18722 0.401658036588469 0.573684020137207 CD99 1 GO:0072710 response to hydroxyurea 1/725 13/18722 0.401658036588469 0.573684020137207 ATRX 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/725 13/18722 0.401658036588469 0.573684020137207 ORMDL1 1 GO:0090158 endoplasmic reticulum membrane organization 1/725 13/18722 0.401658036588469 0.573684020137207 RTN4 1 GO:0090161 Golgi ribbon formation 1/725 13/18722 0.401658036588469 0.573684020137207 TRIP11 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/725 13/18722 0.401658036588469 0.573684020137207 IARS2 1 GO:0120305 regulation of pigmentation 1/725 13/18722 0.401658036588469 0.573684020137207 BCL2 1 GO:1900044 regulation of protein K63-linked ubiquitination 1/725 13/18722 0.401658036588469 0.573684020137207 SASH1 1 GO:1900452 regulation of long-term synaptic depression 1/725 13/18722 0.401658036588469 0.573684020137207 PPP1R9A 1 GO:1901096 regulation of autophagosome maturation 1/725 13/18722 0.401658036588469 0.573684020137207 UVRAG 1 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 1/725 13/18722 0.401658036588469 0.573684020137207 NRP2 1 GO:1903651 positive regulation of cytoplasmic transport 1/725 13/18722 0.401658036588469 0.573684020137207 EZR 1 GO:1903977 positive regulation of glial cell migration 1/725 13/18722 0.401658036588469 0.573684020137207 LRP1 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/725 13/18722 0.401658036588469 0.573684020137207 HUWE1 1 GO:1905038 regulation of membrane lipid metabolic process 1/725 13/18722 0.401658036588469 0.573684020137207 ORMDL1 1 GO:1905203 regulation of connective tissue replacement 1/725 13/18722 0.401658036588469 0.573684020137207 ROCK1 1 GO:2001023 regulation of response to drug 1/725 13/18722 0.401658036588469 0.573684020137207 ADIRF 1 GO:0097696 receptor signaling pathway via STAT 8/725 181/18722 0.402631900368293 0.574751085037137 CAV1/AKR1B1/ISL1/CSH1/IL6ST/SOCS1/GHR/HES1 8 GO:1905952 regulation of lipid localization 8/725 181/18722 0.402631900368293 0.574751085037137 PLIN2/CAV1/LRP1/ITGAV/DBI/C1QTNF1/KDM5B/CYP19A1 8 GO:1901293 nucleoside phosphate biosynthetic process 11/725 256/18722 0.405791491314497 0.579098274063396 SLC26A2/ALDOA/ACSS1/UPP1/PARP1/PNP/TMSB4X/ENO1/MPC2/AK3/RFK 11 GO:1902600 proton transmembrane transport 7/725 157/18722 0.406766168026596 0.5803258389324 ATP6V0E1/TMSB4X/SLC9A1/COX6A1/CYB5A/UQCRH/ATP6V1G1 7 GO:0034440 lipid oxidation 5/725 108/18722 0.407484635631408 0.581187287004955 SLC27A2/CROT/ADH5/HADHA/ECHDC2 5 GO:0002691 regulation of cellular extravasation 2/725 36/18722 0.40892368313535 0.582256783655363 JAM3/CD99 2 GO:0042092 type 2 immune response 2/725 36/18722 0.40892368313535 0.582256783655363 ANXA1/ARG2 2 GO:0045746 negative regulation of Notch signaling pathway 2/725 36/18722 0.40892368313535 0.582256783655363 NEURL1/BMP7 2 GO:0051955 regulation of amino acid transport 2/725 36/18722 0.40892368313535 0.582256783655363 ITGB1/ARL6IP5 2 GO:0070897 transcription preinitiation complex assembly 2/725 36/18722 0.40892368313535 0.582256783655363 BDP1/HMGB1 2 GO:1901658 glycosyl compound catabolic process 2/725 36/18722 0.40892368313535 0.582256783655363 UPP1/PNP 2 GO:1900542 regulation of purine nucleotide metabolic process 4/725 84/18722 0.410426454958726 0.584232434761523 APP/PARP1/TMSB4X/ENO1 4 GO:0006997 nucleus organization 6/725 133/18722 0.410976054669148 0.58479152598339 SF1/RPS19/PLEC/NEK6/NUMA1/RTN4 6 GO:0002712 regulation of B cell mediated immunity 3/725 60/18722 0.41197288208457 0.58479152598339 CD46/TFRC/CD55 3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 3/725 60/18722 0.41197288208457 0.58479152598339 PUM1/HSPA1A/RIPK2 3 GO:0002889 regulation of immunoglobulin mediated immune response 3/725 60/18722 0.41197288208457 0.58479152598339 CD46/TFRC/CD55 3 GO:0030071 regulation of mitotic metaphase/anaphase transition 3/725 60/18722 0.41197288208457 0.58479152598339 DUSP1/NEK6/CENPF 3 GO:0031663 lipopolysaccharide-mediated signaling pathway 3/725 60/18722 0.41197288208457 0.58479152598339 CD55/SASH1/RIPK2 3 GO:0033866 nucleoside bisphosphate biosynthetic process 3/725 60/18722 0.41197288208457 0.58479152598339 SLC26A2/ACSS1/MPC2 3 GO:0034030 ribonucleoside bisphosphate biosynthetic process 3/725 60/18722 0.41197288208457 0.58479152598339 SLC26A2/ACSS1/MPC2 3 GO:0034033 purine nucleoside bisphosphate biosynthetic process 3/725 60/18722 0.41197288208457 0.58479152598339 SLC26A2/ACSS1/MPC2 3 GO:0060038 cardiac muscle cell proliferation 3/725 60/18722 0.41197288208457 0.58479152598339 TGFBR3/GJA1/RBPJ 3 GO:0006644 phospholipid metabolic process 16/725 383/18722 0.414068058067033 0.587601060006101 PRDX6/PLPP3/PISD/ISYNA1/IDH1/DBI/SOCS1/GPX4/CHPT1/TMEM150A/GPCPD1/CDS1/HADHA/PIP4K2A/ARF1/PIK3CB 16 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 10/725 233/18722 0.415624523457988 0.588559009347237 ADGRG1/LGR5/LGR4/ADRB1/GNA12/ARRDC3/PSAP/PDE4B/WASF2/GNAQ 10 GO:0008277 regulation of G protein-coupled receptor signaling pathway 6/725 134/18722 0.417911577709342 0.588559009347237 MET/ARRDC3/PDE4B/NMT1/ROCK1/APELA 6 GO:0032147 activation of protein kinase activity 6/725 134/18722 0.417911577709342 0.588559009347237 RPLP1/SOCS1/GHR/DLG1/HMGB1/PPIA 6 GO:0022412 cellular process involved in reproduction in multicellular organism 16/725 384/18722 0.418152221069648 0.588559009347237 DYNLL1/ITGB1/SPESP1/LGR5/RPS6/NEURL1/DNMT3A/JAM3/DIAPH2/BCL2/EIF2S2/QKI/SLC2A8/CDYL/AFF4/ZFX 16 GO:0002709 regulation of T cell mediated immunity 4/725 85/18722 0.419189930034048 0.588559009347237 HSPD1/CD55/HMGB1/B2M 4 GO:1903169 regulation of calcium ion transmembrane transport 7/725 159/18722 0.419493328288493 0.588559009347237 C4orf3/CALM1/PDE4B/SLC9A1/SRI/GSTO1/CYBA 7 GO:0006900 vesicle budding from membrane 3/725 61/18722 0.42239300000348 0.588559009347237 PDCD6/RAB1A/ARF1 3 GO:0030199 collagen fibril organization 3/725 61/18722 0.42239300000348 0.588559009347237 COL14A1/NF1/SERPINH1 3 GO:0002369 T cell cytokine production 2/725 37/18722 0.422489379160879 0.588559009347237 CD55/B2M 2 GO:0002724 regulation of T cell cytokine production 2/725 37/18722 0.422489379160879 0.588559009347237 CD55/B2M 2 GO:0003016 respiratory system process 2/725 37/18722 0.422489379160879 0.588559009347237 GAA/ADH5 2 GO:0003176 aortic valve development 2/725 37/18722 0.422489379160879 0.588559009347237 RBPJ/ROCK1 2 GO:0006862 nucleotide transport 2/725 37/18722 0.422489379160879 0.588559009347237 GJA1/SLC25A36 2 GO:0031646 positive regulation of nervous system process 2/725 37/18722 0.422489379160879 0.588559009347237 DAG1/DICER1 2 GO:0032885 regulation of polysaccharide biosynthetic process 2/725 37/18722 0.422489379160879 0.588559009347237 IGF2/CLTC 2 GO:0034260 negative regulation of GTPase activity 2/725 37/18722 0.422489379160879 0.588559009347237 HRAS/AMOT 2 GO:0042178 xenobiotic catabolic process 2/725 37/18722 0.422489379160879 0.588559009347237 CYP2J2/GSTO1 2 GO:0043368 positive T cell selection 2/725 37/18722 0.422489379160879 0.588559009347237 CTSL/BCL2 2 GO:0050775 positive regulation of dendrite morphogenesis 2/725 37/18722 0.422489379160879 0.588559009347237 CUX1/DHX36 2 GO:0071985 multivesicular body sorting pathway 2/725 37/18722 0.422489379160879 0.588559009347237 LEPROTL1/UVRAG 2 GO:0090218 positive regulation of lipid kinase activity 2/725 37/18722 0.422489379160879 0.588559009347237 CDC42/FLT1 2 GO:1904659 glucose transmembrane transport 5/725 110/18722 0.422869166852811 0.588559009347237 NFE2L2/OPN3/GPC3/SLC2A8/SLC2A12 5 GO:0000054 ribosomal subunit export from nucleus 1/725 14/18722 0.424844627185153 0.588559009347237 NPM1 1 GO:0000212 meiotic spindle organization 1/725 14/18722 0.424844627185153 0.588559009347237 ATRX 1 GO:0001711 endodermal cell fate commitment 1/725 14/18722 0.424844627185153 0.588559009347237 RTF1 1 GO:0001767 establishment of lymphocyte polarity 1/725 14/18722 0.424844627185153 0.588559009347237 SNX27 1 GO:0001771 immunological synapse formation 1/725 14/18722 0.424844627185153 0.588559009347237 DLG1 1 GO:0002475 antigen processing and presentation via MHC class Ib 1/725 14/18722 0.424844627185153 0.588559009347237 B2M 1 GO:0003188 heart valve formation 1/725 14/18722 0.424844627185153 0.588559009347237 GJA5 1 GO:0003214 cardiac left ventricle morphogenesis 1/725 14/18722 0.424844627185153 0.588559009347237 RBPJ 1 GO:0006596 polyamine biosynthetic process 1/725 14/18722 0.424844627185153 0.588559009347237 OAZ1 1 GO:0006999 nuclear pore organization 1/725 14/18722 0.424844627185153 0.588559009347237 RTN4 1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 1/725 14/18722 0.424844627185153 0.588559009347237 CBLB 1 GO:0009071 serine family amino acid catabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 GLDC 1 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0009214 cyclic nucleotide catabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 PDE4B 1 GO:0010421 hydrogen peroxide-mediated programmed cell death 1/725 14/18722 0.424844627185153 0.588559009347237 MET 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/725 14/18722 0.424844627185153 0.588559009347237 MYLIP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/725 14/18722 0.424844627185153 0.588559009347237 DAG1 1 GO:0019321 pentose metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 RPIA 1 GO:0022038 corpus callosum development 1/725 14/18722 0.424844627185153 0.588559009347237 C12orf57 1 GO:0030049 muscle filament sliding 1/725 14/18722 0.424844627185153 0.588559009347237 MYL6 1 GO:0030213 hyaluronan biosynthetic process 1/725 14/18722 0.424844627185153 0.588559009347237 CLTC 1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/725 14/18722 0.424844627185153 0.588559009347237 PDCD6 1 GO:0031650 regulation of heat generation 1/725 14/18722 0.424844627185153 0.588559009347237 ARRDC3 1 GO:0033750 ribosome localization 1/725 14/18722 0.424844627185153 0.588559009347237 NPM1 1 GO:0034616 response to laminar fluid shear stress 1/725 14/18722 0.424844627185153 0.588559009347237 NFE2L2 1 GO:0035672 oligopeptide transmembrane transport 1/725 14/18722 0.424844627185153 0.588559009347237 GJA1 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/725 14/18722 0.424844627185153 0.588559009347237 DBI 1 GO:0036444 calcium import into the mitochondrion 1/725 14/18722 0.424844627185153 0.588559009347237 AFG3L2 1 GO:0042921 glucocorticoid receptor signaling pathway 1/725 14/18722 0.424844627185153 0.588559009347237 NR3C1 1 GO:0043173 nucleotide salvage 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0043249 erythrocyte maturation 1/725 14/18722 0.424844627185153 0.588559009347237 FAM210B 1 GO:0043922 negative regulation by host of viral transcription 1/725 14/18722 0.424844627185153 0.588559009347237 JUN 1 GO:0045989 positive regulation of striated muscle contraction 1/725 14/18722 0.424844627185153 0.588559009347237 GSTO1 1 GO:0046049 UMP metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0046131 pyrimidine ribonucleoside metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0046133 pyrimidine ribonucleoside catabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 UPP1 1 GO:0046341 CDP-diacylglycerol metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 CDS1 1 GO:0046348 amino sugar catabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 NAGK 1 GO:0046479 glycosphingolipid catabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 HEXA 1 GO:0048148 behavioral response to cocaine 1/725 14/18722 0.424844627185153 0.588559009347237 HOMER1 1 GO:0048291 isotype switching to IgG isotypes 1/725 14/18722 0.424844627185153 0.588559009347237 HSPD1 1 GO:0048875 chemical homeostasis within a tissue 1/725 14/18722 0.424844627185153 0.588559009347237 HOMER1 1 GO:0050930 induction of positive chemotaxis 1/725 14/18722 0.424844627185153 0.588559009347237 PGF 1 GO:0051589 negative regulation of neurotransmitter transport 1/725 14/18722 0.424844627185153 0.588559009347237 PPP1R9A 1 GO:0051917 regulation of fibrinolysis 1/725 14/18722 0.424844627185153 0.588559009347237 SERPINE1 1 GO:0051984 positive regulation of chromosome segregation 1/725 14/18722 0.424844627185153 0.588559009347237 NUMA1 1 GO:0060088 auditory receptor cell stereocilium organization 1/725 14/18722 0.424844627185153 0.588559009347237 TRIOBP 1 GO:0060841 venous blood vessel development 1/725 14/18722 0.424844627185153 0.588559009347237 ENG 1 GO:0061043 regulation of vascular wound healing 1/725 14/18722 0.424844627185153 0.588559009347237 SERPINE1 1 GO:0070278 extracellular matrix constituent secretion 1/725 14/18722 0.424844627185153 0.588559009347237 ENG 1 GO:0071285 cellular response to lithium ion 1/725 14/18722 0.424844627185153 0.588559009347237 CDH1 1 GO:0071481 cellular response to X-ray 1/725 14/18722 0.424844627185153 0.588559009347237 NIPBL 1 GO:0072160 nephron tubule epithelial cell differentiation 1/725 14/18722 0.424844627185153 0.588559009347237 MTSS1 1 GO:0072176 nephric duct development 1/725 14/18722 0.424844627185153 0.588559009347237 GPC3 1 GO:0072350 tricarboxylic acid metabolic process 1/725 14/18722 0.424844627185153 0.588559009347237 IDH1 1 GO:0072498 embryonic skeletal joint development 1/725 14/18722 0.424844627185153 0.588559009347237 BMP7 1 GO:0090128 regulation of synapse maturation 1/725 14/18722 0.424844627185153 0.588559009347237 NEURL1 1 GO:0090715 immunological memory formation process 1/725 14/18722 0.424844627185153 0.588559009347237 CD46 1 GO:0099638 endosome to plasma membrane protein transport 1/725 14/18722 0.424844627185153 0.588559009347237 RAB11A 1 GO:1901857 positive regulation of cellular respiration 1/725 14/18722 0.424844627185153 0.588559009347237 OPN3 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/725 14/18722 0.424844627185153 0.588559009347237 HUWE1 1 GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation 1/725 14/18722 0.424844627185153 0.588559009347237 ENG 1 GO:1905208 negative regulation of cardiocyte differentiation 1/725 14/18722 0.424844627185153 0.588559009347237 EGFR 1 GO:2001140 positive regulation of phospholipid transport 1/725 14/18722 0.424844627185153 0.588559009347237 DBI 1 GO:0002699 positive regulation of immune effector process 10/725 235/18722 0.426095749674502 0.590130971338811 CD46/TFRC/HSPD1/ANXA1/RPS19/DHX36/CD55/RIPK2/SLC7A5/B2M 10 GO:0006140 regulation of nucleotide metabolic process 4/725 86/18722 0.427922588549174 0.591852551529539 APP/PARP1/TMSB4X/ENO1 4 GO:0006493 protein O-linked glycosylation 4/725 86/18722 0.427922588549174 0.591852551529539 GALNT11/C1GALT1/TET2/B3GNT2 4 GO:0015908 fatty acid transport 4/725 86/18722 0.427922588549174 0.591852551529539 PLIN2/ANXA1/SLC27A2/CROT 4 GO:0022406 membrane docking 4/725 86/18722 0.427922588549174 0.591852551529539 CALM1/EZR/ROCK1/RALB 4 GO:2000117 negative regulation of cysteine-type endopeptidase activity 4/725 86/18722 0.427922588549174 0.591852551529539 SERPINB9/DHCR24/HERPUD1/MDM2 4 GO:0015718 monocarboxylic acid transport 5/725 111/18722 0.43053498827519 0.595303288479797 ANXA1/SLC6A8/SLC16A12/MPC2/SLC16A3 5 GO:0043624 cellular protein complex disassembly 6/725 136/18722 0.431751083348424 0.596575280917134 HSPA8/TRIOBP/CFL1/EIF5A/CCSAP/CAPZB 6 GO:0051650 establishment of vesicle localization 7/725 161/18722 0.432195571232795 0.596575280917134 KIF5B/PDCD6/DYNC1H1/TRIP11/RAB11A/RAB1A/ARF1 7 GO:0002260 lymphocyte homeostasis 3/725 62/18722 0.43274951823482 0.596575280917134 PMAIP1/RPS6/BCL2 3 GO:0007062 sister chromatid cohesion 3/725 62/18722 0.43274951823482 0.596575280917134 ATRX/NIPBL/STAG1 3 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3/725 62/18722 0.43274951823482 0.596575280917134 DUSP1/NEK6/CENPF 3 GO:0009311 oligosaccharide metabolic process 3/725 62/18722 0.43274951823482 0.596575280917134 GAA/FUT8/MANBA 3 GO:0010573 vascular endothelial growth factor production 3/725 62/18722 0.43274951823482 0.596575280917134 ADGRG1/ISL1/IL6ST 3 GO:0032613 interleukin-10 production 3/725 62/18722 0.43274951823482 0.596575280917134 CD46/HSPD1/HMGB1 3 GO:0032653 regulation of interleukin-10 production 3/725 62/18722 0.43274951823482 0.596575280917134 CD46/HSPD1/HMGB1 3 GO:0045428 regulation of nitric oxide biosynthetic process 3/725 62/18722 0.43274951823482 0.596575280917134 DYNLL1/CAV1/RAC1 3 GO:0046824 positive regulation of nucleocytoplasmic transport 3/725 62/18722 0.43274951823482 0.596575280917134 CDH1/GLI3/MDM2 3 GO:0070588 calcium ion transmembrane transport 13/725 312/18722 0.4336293359697 0.597625640030019 ATP2B1/C4orf3/ITGAV/CALM1/TMEM37/PDE4B/AFG3L2/SLC9A1/ERO1A/DDIT3/SRI/GSTO1/CYBA 13 GO:0031330 negative regulation of cellular catabolic process 11/725 262/18722 0.435639149487088 0.598466578318064 FUS/MET/DHX36/ROCK1/BCL2/LARP1/EIF3H/TIMP3/TIMP2/SDCBP/YBX1 11 GO:0001825 blastocyst formation 2/725 38/18722 0.435892406224165 0.598466578318064 HOPX/RTN4 2 GO:0006882 cellular zinc ion homeostasis 2/725 38/18722 0.435892406224165 0.598466578318064 SLC39A10/S100A9 2 GO:0007007 inner mitochondrial membrane organization 2/725 38/18722 0.435892406224165 0.598466578318064 AFG3L2/CHCHD10 2 GO:0007094 mitotic spindle assembly checkpoint signaling 2/725 38/18722 0.435892406224165 0.598466578318064 DUSP1/CENPF 2 GO:0030279 negative regulation of ossification 2/725 38/18722 0.435892406224165 0.598466578318064 RBPJ/BCL2 2 GO:0032373 positive regulation of sterol transport 2/725 38/18722 0.435892406224165 0.598466578318064 CAV1/LRP1 2 GO:0032376 positive regulation of cholesterol transport 2/725 38/18722 0.435892406224165 0.598466578318064 CAV1/LRP1 2 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 2/725 38/18722 0.435892406224165 0.598466578318064 ISL1/RHOA 2 GO:0071173 spindle assembly checkpoint signaling 2/725 38/18722 0.435892406224165 0.598466578318064 DUSP1/CENPF 2 GO:0071174 mitotic spindle checkpoint signaling 2/725 38/18722 0.435892406224165 0.598466578318064 DUSP1/CENPF 2 GO:0098926 postsynaptic signal transduction 2/725 38/18722 0.435892406224165 0.598466578318064 GNAQ/LY6E 2 GO:0099622 cardiac muscle cell membrane repolarization 2/725 38/18722 0.435892406224165 0.598466578318064 AKAP9/GJA5 2 GO:1903725 regulation of phospholipid metabolic process 2/725 38/18722 0.435892406224165 0.598466578318064 IDH1/ARF1 2 GO:0019915 lipid storage 4/725 87/18722 0.436620819753236 0.599304342087504 PLIN2/CAV1/ITGAV/CDS1 4 GO:0008203 cholesterol metabolic process 6/725 137/18722 0.438651133864473 0.600721367609278 APP/CYP11A1/DHCR24/LRP5/CAT/FDX1 6 GO:0045471 response to ethanol 6/725 137/18722 0.438651133864473 0.600721367609278 EEF1B2/RPL15/DNMT3A/RHOA/RPL10A/CAT 6 GO:0002697 regulation of immune effector process 14/725 339/18722 0.44133530632489 0.600721367609278 SERPINB9/CD46/TFRC/HSPD1/PRKDC/ANXA1/GRN/RPS19/DHX36/CD55/RIPK2/HMGB1/SLC7A5/B2M 14 GO:0006631 fatty acid metabolic process 16/725 390/18722 0.442677541427625 0.600721367609278 CYP2J2/CAV1/MIF/ACSS1/AKR1B1/HACD3/ANXA1/SLC27A2/CROT/SCD/LPIN2/GPX4/ADH5/HADHA/QKI/ECHDC2 16 GO:0001947 heart looping 3/725 63/18722 0.443037178015183 0.600721367609278 TBX3/MIB1/ENG 3 GO:0002704 negative regulation of leukocyte mediated immunity 3/725 63/18722 0.443037178015183 0.600721367609278 SERPINB9/CD46/CD55 3 GO:0022617 extracellular matrix disassembly 3/725 63/18722 0.443037178015183 0.600721367609278 LRP1/LAMC1/CTSV 3 GO:0099601 regulation of neurotransmitter receptor activity 3/725 63/18722 0.443037178015183 0.600721367609278 AKAP9/APP/HOMER1 3 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3/725 63/18722 0.443037178015183 0.600721367609278 DUSP1/NEK6/CENPF 3 GO:1902373 negative regulation of mRNA catabolic process 3/725 63/18722 0.443037178015183 0.600721367609278 FUS/LARP1/YBX1 3 GO:1904589 regulation of protein import 3/725 63/18722 0.443037178015183 0.600721367609278 HSPA8/CDH1/GLI3 3 GO:0001906 cell killing 8/725 188/18722 0.443954126139204 0.600721367609278 GAPDH/SERPINB9/KIF5B/CTSC/RPS19/CD55/ARL8B/B2M 8 GO:0006633 fatty acid biosynthetic process 7/725 163/18722 0.444860493209081 0.600721367609278 MIF/ACSS1/HACD3/ANXA1/SCD/GPX4/QKI 7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/725 15/18722 0.447133896229988 0.600721367609278 RPL7 1 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/725 15/18722 0.447133896229988 0.600721367609278 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/725 15/18722 0.447133896229988 0.600721367609278 RPS21 1 GO:0000722 telomere maintenance via recombination 1/725 15/18722 0.447133896229988 0.600721367609278 RAD50 1 GO:0002730 regulation of dendritic cell cytokine production 1/725 15/18722 0.447133896229988 0.600721367609278 DHX36 1 GO:0002836 positive regulation of response to tumor cell 1/725 15/18722 0.447133896229988 0.600721367609278 HSPD1 1 GO:0002839 positive regulation of immune response to tumor cell 1/725 15/18722 0.447133896229988 0.600721367609278 HSPD1 1 GO:0003356 regulation of cilium beat frequency 1/725 15/18722 0.447133896229988 0.600721367609278 CCSAP 1 GO:0006089 lactate metabolic process 1/725 15/18722 0.447133896229988 0.600721367609278 LDHA 1 GO:0006098 pentose-phosphate shunt 1/725 15/18722 0.447133896229988 0.600721367609278 RPIA 1 GO:0006268 DNA unwinding involved in DNA replication 1/725 15/18722 0.447133896229988 0.600721367609278 PURA 1 GO:0006704 glucocorticoid biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 CYP11A1 1 GO:0007000 nucleolus organization 1/725 15/18722 0.447133896229988 0.600721367609278 RPS19 1 GO:0007216 G protein-coupled glutamate receptor signaling pathway 1/725 15/18722 0.447133896229988 0.600721367609278 HOMER1 1 GO:0009163 nucleoside biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 PNP 1 GO:0010763 positive regulation of fibroblast migration 1/725 15/18722 0.447133896229988 0.600721367609278 ITGB1 1 GO:0010889 regulation of sequestering of triglyceride 1/725 15/18722 0.447133896229988 0.600721367609278 PLIN2 1 GO:0014733 regulation of skeletal muscle adaptation 1/725 15/18722 0.447133896229988 0.600721367609278 CAMK2G 1 GO:0014841 skeletal muscle satellite cell proliferation 1/725 15/18722 0.447133896229988 0.600721367609278 CFLAR 1 GO:0014857 regulation of skeletal muscle cell proliferation 1/725 15/18722 0.447133896229988 0.600721367609278 CFLAR 1 GO:0016114 terpenoid biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 RDH10 1 GO:0018146 keratan sulfate biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 B3GNT2 1 GO:0018298 protein-chromophore linkage 1/725 15/18722 0.447133896229988 0.600721367609278 OPN3 1 GO:0021542 dentate gyrus development 1/725 15/18722 0.447133896229988 0.600721367609278 BTG2 1 GO:0023035 CD40 signaling pathway 1/725 15/18722 0.447133896229988 0.600721367609278 ITGB1 1 GO:0031269 pseudopodium assembly 1/725 15/18722 0.447133896229988 0.600721367609278 CDC42 1 GO:0031958 corticosteroid receptor signaling pathway 1/725 15/18722 0.447133896229988 0.600721367609278 NR3C1 1 GO:0032239 regulation of nucleobase-containing compound transport 1/725 15/18722 0.447133896229988 0.600721367609278 SETD2 1 GO:0032354 response to follicle-stimulating hormone 1/725 15/18722 0.447133896229988 0.600721367609278 TGFBR3 1 GO:0032486 Rap protein signal transduction 1/725 15/18722 0.447133896229988 0.600721367609278 TIMP2 1 GO:0032488 Cdc42 protein signal transduction 1/725 15/18722 0.447133896229988 0.600721367609278 CDC42 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/725 15/18722 0.447133896229988 0.600721367609278 ISL1 1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/725 15/18722 0.447133896229988 0.600721367609278 ISL1 1 GO:0033275 actin-myosin filament sliding 1/725 15/18722 0.447133896229988 0.600721367609278 MYL6 1 GO:0034404 nucleobase-containing small molecule biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 PNP 1 GO:0035435 phosphate ion transmembrane transport 1/725 15/18722 0.447133896229988 0.600721367609278 SLC20A1 1 GO:0036124 histone H3-K9 trimethylation 1/725 15/18722 0.447133896229988 0.600721367609278 ATRX 1 GO:0036376 sodium ion export across plasma membrane 1/725 15/18722 0.447133896229988 0.600721367609278 SLC9A1 1 GO:0043508 negative regulation of JUN kinase activity 1/725 15/18722 0.447133896229988 0.600721367609278 PDCD4 1 GO:0043981 histone H4-K5 acetylation 1/725 15/18722 0.447133896229988 0.600721367609278 PHF20 1 GO:0043982 histone H4-K8 acetylation 1/725 15/18722 0.447133896229988 0.600721367609278 PHF20 1 GO:0045064 T-helper 2 cell differentiation 1/725 15/18722 0.447133896229988 0.600721367609278 ANXA1 1 GO:0045217 cell-cell junction maintenance 1/725 15/18722 0.447133896229988 0.600721367609278 MTSS1 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 IGF2 1 GO:0046184 aldehyde biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 TPI1 1 GO:0046459 short-chain fatty acid metabolic process 1/725 15/18722 0.447133896229988 0.600721367609278 ACSS1 1 GO:0051127 positive regulation of actin nucleation 1/725 15/18722 0.447133896229988 0.600721367609278 WASF2 1 GO:0051775 response to redox state 1/725 15/18722 0.447133896229988 0.600721367609278 ADH5 1 GO:0051791 medium-chain fatty acid metabolic process 1/725 15/18722 0.447133896229988 0.600721367609278 CROT 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/725 15/18722 0.447133896229988 0.600721367609278 ARF1 1 GO:0070207 protein homotrimerization 1/725 15/18722 0.447133896229988 0.600721367609278 MIF 1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 1/725 15/18722 0.447133896229988 0.600721367609278 SLC9A1 1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 1/725 15/18722 0.447133896229988 0.600721367609278 NPM1 1 GO:0072224 metanephric glomerulus development 1/725 15/18722 0.447133896229988 0.600721367609278 LGR4 1 GO:0090110 COPII-coated vesicle cargo loading 1/725 15/18722 0.447133896229988 0.600721367609278 RAB1A 1 GO:0090594 inflammatory response to wounding 1/725 15/18722 0.447133896229988 0.600721367609278 GRN 1 GO:0097468 programmed cell death in response to reactive oxygen species 1/725 15/18722 0.447133896229988 0.600721367609278 MET 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/725 15/18722 0.447133896229988 0.600721367609278 CDH1 1 GO:0106058 positive regulation of calcineurin-mediated signaling 1/725 15/18722 0.447133896229988 0.600721367609278 SLC9A1 1 GO:0150011 regulation of neuron projection arborization 1/725 15/18722 0.447133896229988 0.600721367609278 MACF1 1 GO:1901741 positive regulation of myoblast fusion 1/725 15/18722 0.447133896229988 0.600721367609278 GDF15 1 GO:1903543 positive regulation of exosomal secretion 1/725 15/18722 0.447133896229988 0.600721367609278 SDCBP 1 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 1/725 15/18722 0.447133896229988 0.600721367609278 NOP10 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/725 15/18722 0.447133896229988 0.600721367609278 GPC3 1 GO:2000345 regulation of hepatocyte proliferation 1/725 15/18722 0.447133896229988 0.600721367609278 CFLAR 1 GO:2001138 regulation of phospholipid transport 1/725 15/18722 0.447133896229988 0.600721367609278 DBI 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/725 15/18722 0.447133896229988 0.600721367609278 ANXA1 1 GO:0072330 monocarboxylic acid biosynthetic process 9/725 214/18722 0.448431337734103 0.601642360755324 MIF/ACSS1/HACD3/ANXA1/SLC27A2/SCD/RDH10/GPX4/QKI 9 GO:0071103 DNA conformation change 12/725 290/18722 0.448892059389562 0.601642360755324 HMGB3/ANXA1/NASP/NPM1/ATRX/DHX36/HP1BP3/RAD50/BRD2/PURA/CHD4/HMGB1 12 GO:0007618 mating 2/725 39/18722 0.449125013434237 0.601642360755324 APP/SLC6A4 2 GO:0017158 regulation of calcium ion-dependent exocytosis 2/725 39/18722 0.449125013434237 0.601642360755324 SYT7/ARF1 2 GO:0031577 spindle checkpoint signaling 2/725 39/18722 0.449125013434237 0.601642360755324 DUSP1/CENPF 2 GO:0032728 positive regulation of interferon-beta production 2/725 39/18722 0.449125013434237 0.601642360755324 RIPK2/HMGB1 2 GO:0045622 regulation of T-helper cell differentiation 2/725 39/18722 0.449125013434237 0.601642360755324 ANXA1/RIPK2 2 GO:0045823 positive regulation of heart contraction 2/725 39/18722 0.449125013434237 0.601642360755324 ADRB1/APELA 2 GO:0046621 negative regulation of organ growth 2/725 39/18722 0.449125013434237 0.601642360755324 GJA1/SLC6A4 2 GO:1902742 apoptotic process involved in development 2/725 39/18722 0.449125013434237 0.601642360755324 LRP5/BMP7 2 GO:2000785 regulation of autophagosome assembly 2/725 39/18722 0.449125013434237 0.601642360755324 RALB/PIP4K2A 2 GO:0009060 aerobic respiration 8/725 189/18722 0.449831726438055 0.602429860320872 IDH1/RHOA/COX6A1/CAT/UQCRH/CHCHD2/SDHA/CHCHD10 8 GO:0051783 regulation of nuclear division 6/725 139/18722 0.452402303972238 0.605443754472508 IGF2/DUSP1/LRP5/BMP7/CDC42/CENPF 6 GO:0001885 endothelial cell development 3/725 64/18722 0.453251010982232 0.605443754472508 MET/EZR/ROCK1 3 GO:0006940 regulation of smooth muscle contraction 3/725 64/18722 0.453251010982232 0.605443754472508 ATP2B1/CAV1/RHOA 3 GO:0030858 positive regulation of epithelial cell differentiation 3/725 64/18722 0.453251010982232 0.605443754472508 NCOA3/NUMA1/SERPINE1 3 GO:0046888 negative regulation of hormone secretion 3/725 64/18722 0.453251010982232 0.605443754472508 GJA1/RAB11FIP1/INHA 3 GO:0070542 response to fatty acid 3/725 64/18722 0.453251010982232 0.605443754472508 GLDC/SCD/CAT 3 GO:0080164 regulation of nitric oxide metabolic process 3/725 64/18722 0.453251010982232 0.605443754472508 DYNLL1/CAV1/RAC1 3 GO:0002286 T cell activation involved in immune response 5/725 114/18722 0.453396033138221 0.605443754472508 CD46/RPS6/ANXA1/RIPK2/HMGB1 5 GO:0008645 hexose transmembrane transport 5/725 114/18722 0.453396033138221 0.605443754472508 NFE2L2/OPN3/GPC3/SLC2A8/SLC2A12 5 GO:0022904 respiratory electron transport chain 5/725 114/18722 0.453396033138221 0.605443754472508 PLEC/COX6A1/UQCRH/CHCHD2/SDHA 5 GO:0051261 protein depolymerization 5/725 114/18722 0.453396033138221 0.605443754472508 HSPA8/TRIOBP/CFL1/CCSAP/CAPZB 5 GO:0009566 fertilization 8/725 190/18722 0.45569925136647 0.608359100652261 ALDOA/SPESP1/CD46/NR2F2/ASH1L/KDM5B/ZFX/SNU13 8 GO:0071824 protein-DNA complex subunit organization 10/725 241/18722 0.45743182324852 0.610249049709933 NASP/NPM1/BPTF/ATRX/HP1BP3/BDP1/BRD2/SETD2/HMGB1/CENPF 10 GO:0032635 interleukin-6 production 7/725 165/18722 0.457476107496103 0.610249049709933 APP/HSPD1/ISL1/CEBPB/RIPK2/HMGB1/CYBA 7 GO:0032675 regulation of interleukin-6 production 7/725 165/18722 0.457476107496103 0.610249049709933 APP/HSPD1/ISL1/CEBPB/RIPK2/HMGB1/CYBA 7 GO:0006164 purine nucleotide biosynthetic process 8/725 191/18722 0.461555519995876 0.613570988383172 SLC26A2/ALDOA/ACSS1/PARP1/TMSB4X/ENO1/MPC2/AK3 8 GO:0010543 regulation of platelet activation 2/725 40/18722 0.462180292218809 0.613570988383172 IL6ST/C1QTNF1 2 GO:0031297 replication fork processing 2/725 40/18722 0.462180292218809 0.613570988383172 ATRX/BOD1L1 2 GO:0045022 early endosome to late endosome transport 2/725 40/18722 0.462180292218809 0.613570988383172 EZR/HOOK3 2 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/725 40/18722 0.462180292218809 0.613570988383172 DUSP1/CENPF 2 GO:0055069 zinc ion homeostasis 2/725 40/18722 0.462180292218809 0.613570988383172 SLC39A10/S100A9 2 GO:0070266 necroptotic process 2/725 40/18722 0.462180292218809 0.613570988383172 CAV1/CFLAR 2 GO:0150077 regulation of neuroinflammatory response 2/725 40/18722 0.462180292218809 0.613570988383172 CTSC/GRN 2 GO:1901223 negative regulation of NIK/NF-kappaB signaling 2/725 40/18722 0.462180292218809 0.613570988383172 TMSB4X/BMP7 2 GO:1901998 toxin transport 2/725 40/18722 0.462180292218809 0.613570988383172 HSPA5/ANTXR2 2 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 2/725 40/18722 0.462180292218809 0.613570988383172 RHOA/NFAT5 2 GO:0061097 regulation of protein tyrosine kinase activity 4/725 90/18722 0.462474787185131 0.613570988383172 CAV1/APP/NEURL1/CBLB 4 GO:0010965 regulation of mitotic sister chromatid separation 3/725 65/18722 0.463386332783318 0.613570988383172 DUSP1/NEK6/CENPF 3 GO:0015909 long-chain fatty acid transport 3/725 65/18722 0.463386332783318 0.613570988383172 PLIN2/ANXA1/SLC27A2 3 GO:0038034 signal transduction in absence of ligand 3/725 65/18722 0.463386332783318 0.613570988383172 ITGAV/BCL2/HSPA1A 3 GO:0044784 metaphase/anaphase transition of cell cycle 3/725 65/18722 0.463386332783318 0.613570988383172 DUSP1/NEK6/CENPF 3 GO:0072577 endothelial cell apoptotic process 3/725 65/18722 0.463386332783318 0.613570988383172 PDCD4/NFE2L2/SERPINE1 3 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 3/725 65/18722 0.463386332783318 0.613570988383172 ITGAV/BCL2/HSPA1A 3 GO:0070374 positive regulation of ERK1 and ERK2 cascade 9/725 217/18722 0.464943840547406 0.613570988383172 LRP1/MIF/APP/EGFR/APELA/HRAS/CFLAR/RIPK2/HMGB1 9 GO:0006119 oxidative phosphorylation 6/725 141/18722 0.466076016491904 0.613570988383172 RHOA/COX6A1/UQCRH/CHCHD2/SDHA/CHCHD10 6 GO:0030183 B cell differentiation 6/725 141/18722 0.466076016491904 0.613570988383172 ITGB1/PRKDC/RBPJ/TPD52/BCL2/INHA 6 GO:0015749 monosaccharide transmembrane transport 5/725 116/18722 0.468498892066399 0.613570988383172 NFE2L2/OPN3/GPC3/SLC2A8/SLC2A12 5 GO:0002093 auditory receptor cell morphogenesis 1/725 16/18722 0.468560523975391 0.613570988383172 TRIOBP 1 GO:0002371 dendritic cell cytokine production 1/725 16/18722 0.468560523975391 0.613570988383172 DHX36 1 GO:0002399 MHC class II protein complex assembly 1/725 16/18722 0.468560523975391 0.613570988383172 B2M 1 GO:0002503 peptide antigen assembly with MHC class II protein complex 1/725 16/18722 0.468560523975391 0.613570988383172 B2M 1 GO:0002827 positive regulation of T-helper 1 type immune response 1/725 16/18722 0.468560523975391 0.613570988383172 RIPK2 1 GO:0006004 fucose metabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 FUT8 1 GO:0006266 DNA ligation 1/725 16/18722 0.468560523975391 0.613570988383172 HMGB1 1 GO:0006544 glycine metabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 GLDC 1 GO:0006555 methionine metabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 MTR 1 GO:0006740 NADPH regeneration 1/725 16/18722 0.468560523975391 0.613570988383172 RPIA 1 GO:0006750 glutathione biosynthetic process 1/725 16/18722 0.468560523975391 0.613570988383172 NFE2L2 1 GO:0006857 oligopeptide transport 1/725 16/18722 0.468560523975391 0.613570988383172 GJA1 1 GO:0009048 dosage compensation by inactivation of X chromosome 1/725 16/18722 0.468560523975391 0.613570988383172 CDYL 1 GO:0009299 mRNA transcription 1/725 16/18722 0.468560523975391 0.613570988383172 DDX5 1 GO:0019377 glycolipid catabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 HEXA 1 GO:0030033 microvillus assembly 1/725 16/18722 0.468560523975391 0.613570988383172 EZR 1 GO:0030575 nuclear body organization 1/725 16/18722 0.468560523975391 0.613570988383172 SF1 1 GO:0031268 pseudopodium organization 1/725 16/18722 0.468560523975391 0.613570988383172 CDC42 1 GO:0034116 positive regulation of heterotypic cell-cell adhesion 1/725 16/18722 0.468560523975391 0.613570988383172 BMP7 1 GO:0034393 positive regulation of smooth muscle cell apoptotic process 1/725 16/18722 0.468560523975391 0.613570988383172 PDCD4 1 GO:0035067 negative regulation of histone acetylation 1/725 16/18722 0.468560523975391 0.613570988383172 ZNF451 1 GO:0035970 peptidyl-threonine dephosphorylation 1/725 16/18722 0.468560523975391 0.613570988383172 DUSP1 1 GO:0042481 regulation of odontogenesis 1/725 16/18722 0.468560523975391 0.613570988383172 SP6 1 GO:0043923 positive regulation by host of viral transcription 1/725 16/18722 0.468560523975391 0.613570988383172 JUN 1 GO:0045722 positive regulation of gluconeogenesis 1/725 16/18722 0.468560523975391 0.613570988383172 DDB1 1 GO:0045838 positive regulation of membrane potential 1/725 16/18722 0.468560523975391 0.613570988383172 GLRX 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/725 16/18722 0.468560523975391 0.613570988383172 MPHOSPH8 1 GO:0046037 GMP metabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 DLG1 1 GO:0046135 pyrimidine nucleoside catabolic process 1/725 16/18722 0.468560523975391 0.613570988383172 UPP1 1 GO:0050862 positive regulation of T cell receptor signaling pathway 1/725 16/18722 0.468560523975391 0.613570988383172 KCNN4 1 GO:0051014 actin filament severing 1/725 16/18722 0.468560523975391 0.613570988383172 CFL1 1 GO:0060004 reflex 1/725 16/18722 0.468560523975391 0.613570988383172 AFG3L2 1 GO:0060330 regulation of response to interferon-gamma 1/725 16/18722 0.468560523975391 0.613570988383172 SOCS1 1 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1/725 16/18722 0.468560523975391 0.613570988383172 SOCS1 1 GO:0061548 ganglion development 1/725 16/18722 0.468560523975391 0.613570988383172 NRP2 1 GO:0070242 thymocyte apoptotic process 1/725 16/18722 0.468560523975391 0.613570988383172 GLI3 1 GO:0071361 cellular response to ethanol 1/725 16/18722 0.468560523975391 0.613570988383172 DNMT3A 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/725 16/18722 0.468560523975391 0.613570988383172 HMGB1 1 GO:0090231 regulation of spindle checkpoint 1/725 16/18722 0.468560523975391 0.613570988383172 DUSP1 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/725 16/18722 0.468560523975391 0.613570988383172 DUSP1 1 GO:0090336 positive regulation of brown fat cell differentiation 1/725 16/18722 0.468560523975391 0.613570988383172 BMP7 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/725 16/18722 0.468560523975391 0.613570988383172 ATP2B1 1 GO:1903504 regulation of mitotic spindle checkpoint 1/725 16/18722 0.468560523975391 0.613570988383172 DUSP1 1 GO:1904683 regulation of metalloendopeptidase activity 1/725 16/18722 0.468560523975391 0.613570988383172 TIMP3 1 GO:1905906 regulation of amyloid fibril formation 1/725 16/18722 0.468560523975391 0.613570988383172 APP 1 GO:2000001 regulation of DNA damage checkpoint 1/725 16/18722 0.468560523975391 0.613570988383172 PPP1R10 1 GO:2000846 regulation of corticosteroid hormone secretion 1/725 16/18722 0.468560523975391 0.613570988383172 C1QTNF1 1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 1/725 16/18722 0.468560523975391 0.613570988383172 PRKDC 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/725 16/18722 0.468560523975391 0.613570988383172 CD63 1 GO:0009895 negative regulation of catabolic process 13/725 320/18722 0.469980203271848 0.615019732435586 FUS/EGFR/MET/MYCBP2/DHX36/ROCK1/BCL2/LARP1/EIF3H/TIMP3/TIMP2/SDCBP/YBX1 13 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 7/725 167/18722 0.470030862784664 0.615019732435586 ITGB1/TENM3/CDH1/DSC3/DSG2/PCDH11X/DSC2 7 GO:0034728 nucleosome organization 7/725 167/18722 0.470030862784664 0.615019732435586 NASP/NPM1/BPTF/ATRX/HP1BP3/BRD2/SETD2 7 GO:0010876 lipid localization 18/725 448/18722 0.47051970760181 0.615500489763503 PLIN2/CAV1/LRP1/ITGAV/KCNN4/ANXA1/SLC27A2/CROT/ABCB1/PSAP/DBI/CDS1/SYT7/C1QTNF1/PIP4K2A/KDM5B/CYP19A1/ARL8B 18 GO:0098661 inorganic anion transmembrane transport 4/725 91/18722 0.471001792525975 0.615972158491787 SLC26A2/GABRE/SLC13A4/SLC20A1 4 GO:0097553 calcium ion transmembrane import into cytosol 6/725 142/18722 0.4728794045025 0.618268171633524 CALM1/ERO1A/DDIT3/SRI/GSTO1/CYBA 6 GO:0042093 T-helper cell differentiation 3/725 66/18722 0.473438736428283 0.618520864679116 ANXA1/RIPK2/HMGB1 3 GO:2000272 negative regulation of signaling receptor activity 3/725 66/18722 0.473438736428283 0.618520864679116 LRPAP1/LY6E/CBLB 3 GO:2000573 positive regulation of DNA biosynthetic process 3/725 66/18722 0.473438736428283 0.618520864679116 MAP3K4/PKIB/HNRNPA1 3 GO:0007099 centriole replication 2/725 41/18722 0.475052122868476 0.619510988119451 CEP152/NPM1 2 GO:0042307 positive regulation of protein import into nucleus 2/725 41/18722 0.475052122868476 0.619510988119451 CDH1/GLI3 2 GO:0048286 lung alveolus development 2/725 41/18722 0.475052122868476 0.619510988119451 MAN1A2/HOPX 2 GO:0051693 actin filament capping 2/725 41/18722 0.475052122868476 0.619510988119451 TRIOBP/CAPZB 2 GO:0055023 positive regulation of cardiac muscle tissue growth 2/725 41/18722 0.475052122868476 0.619510988119451 TGFBR3/RBPJ 2 GO:0071470 cellular response to osmotic stress 2/725 41/18722 0.475052122868476 0.619510988119451 AKR1B1/EFHD1 2 GO:1903524 positive regulation of blood circulation 2/725 41/18722 0.475052122868476 0.619510988119451 ADRB1/APELA 2 GO:0002702 positive regulation of production of molecular mediator of immune response 5/725 117/18722 0.476002090917107 0.6204305988323 TFRC/DHX36/CD55/SLC7A5/B2M 5 GO:0030301 cholesterol transport 5/725 117/18722 0.476002090917107 0.6204305988323 CAV1/LRP1/SYT7/PIP4K2A/ARL8B 5 GO:0002706 regulation of lymphocyte mediated immunity 7/725 168/18722 0.476281931529601 0.620635761162865 SERPINB9/CD46/TFRC/HSPD1/CD55/HMGB1/B2M 7 GO:0043087 regulation of GTPase activity 14/725 348/18722 0.480628141060365 0.626138279885632 SYDE1/IQGAP2/ITGB1/ITGA6/ADRB1/MET/NF1/CCPG1/IQGAP1/NET1/HRAS/AMOT/RASA1/CBLB 14 GO:0016445 somatic diversification of immunoglobulins 3/725 67/18722 0.483404085427887 0.626938344463772 TFRC/HSPD1/PRKDC 3 GO:0043967 histone H4 acetylation 3/725 67/18722 0.483404085427887 0.626938344463772 PHF20/USP22/MORF4L2 3 GO:0051306 mitotic sister chromatid separation 3/725 67/18722 0.483404085427887 0.626938344463772 DUSP1/NEK6/CENPF 3 GO:0061371 determination of heart left/right asymmetry 3/725 67/18722 0.483404085427887 0.626938344463772 TBX3/MIB1/ENG 3 GO:0034219 carbohydrate transmembrane transport 5/725 118/18722 0.483470242850312 0.626938344463772 NFE2L2/OPN3/GPC3/SLC2A8/SLC2A12 5 GO:0006040 amino sugar metabolic process 2/725 42/18722 0.487735123948551 0.626938344463772 EXTL2/NAGK 2 GO:0009124 nucleoside monophosphate biosynthetic process 2/725 42/18722 0.487735123948551 0.626938344463772 UPP1/RFK 2 GO:0010939 regulation of necrotic cell death 2/725 42/18722 0.487735123948551 0.626938344463772 CAV1/CFLAR 2 GO:0021575 hindbrain morphogenesis 2/725 42/18722 0.487735123948551 0.626938344463772 HSPA5/HES1 2 GO:0030574 collagen catabolic process 2/725 42/18722 0.487735123948551 0.626938344463772 ITGB1/CTSL 2 GO:0032965 regulation of collagen biosynthetic process 2/725 42/18722 0.487735123948551 0.626938344463772 SUCO/ENG 2 GO:0043507 positive regulation of JUN kinase activity 2/725 42/18722 0.487735123948551 0.626938344463772 MAP3K4/SASH1 2 GO:0046596 regulation of viral entry into host cell 2/725 42/18722 0.487735123948551 0.626938344463772 P4HB/LY6E 2 GO:0048489 synaptic vesicle transport 2/725 42/18722 0.487735123948551 0.626938344463772 KIF5B/ARF1 2 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/725 42/18722 0.487735123948551 0.626938344463772 DUSP1/CENPF 2 GO:2000404 regulation of T cell migration 2/725 42/18722 0.487735123948551 0.626938344463772 APP/RHOA 2 GO:0000097 sulfur amino acid biosynthetic process 1/725 17/18722 0.489157852111702 0.626938344463772 MTR 1 GO:0001829 trophectodermal cell differentiation 1/725 17/18722 0.489157852111702 0.626938344463772 HOPX 1 GO:0002031 G protein-coupled receptor internalization 1/725 17/18722 0.489157852111702 0.626938344463772 APELA 1 GO:0003184 pulmonary valve morphogenesis 1/725 17/18722 0.489157852111702 0.626938344463772 GJA5 1 GO:0006474 N-terminal protein amino acid acetylation 1/725 17/18722 0.489157852111702 0.626938344463772 SOX4 1 GO:0006577 amino-acid betaine metabolic process 1/725 17/18722 0.489157852111702 0.626938344463772 CROT 1 GO:0006901 vesicle coating 1/725 17/18722 0.489157852111702 0.626938344463772 PDCD6 1 GO:0008340 determination of adult lifespan 1/725 17/18722 0.489157852111702 0.626938344463772 TFCP2L1 1 GO:0009084 glutamine family amino acid biosynthetic process 1/725 17/18722 0.489157852111702 0.626938344463772 GLUL 1 GO:0009151 purine deoxyribonucleotide metabolic process 1/725 17/18722 0.489157852111702 0.626938344463772 PNP 1 GO:0010715 regulation of extracellular matrix disassembly 1/725 17/18722 0.489157852111702 0.626938344463772 LRP1 1 GO:0014856 skeletal muscle cell proliferation 1/725 17/18722 0.489157852111702 0.626938344463772 CFLAR 1 GO:0015867 ATP transport 1/725 17/18722 0.489157852111702 0.626938344463772 GJA1 1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 1/725 17/18722 0.489157852111702 0.626938344463772 B2M 1 GO:0021513 spinal cord dorsal/ventral patterning 1/725 17/18722 0.489157852111702 0.626938344463772 GLI3 1 GO:0030903 notochord development 1/725 17/18722 0.489157852111702 0.626938344463772 COBL 1 GO:0032048 cardiolipin metabolic process 1/725 17/18722 0.489157852111702 0.626938344463772 HADHA 1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 1/725 17/18722 0.489157852111702 0.626938344463772 LEPROTL1 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/725 17/18722 0.489157852111702 0.626938344463772 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/725 17/18722 0.489157852111702 0.626938344463772 ISL1 1 GO:0033623 regulation of integrin activation 1/725 17/18722 0.489157852111702 0.626938344463772 JAM3 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/725 17/18722 0.489157852111702 0.626938344463772 LGMN 1 GO:0036035 osteoclast development 1/725 17/18722 0.489157852111702 0.626938344463772 FBN1 1 GO:0036065 fucosylation 1/725 17/18722 0.489157852111702 0.626938344463772 FUT8 1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1/725 17/18722 0.489157852111702 0.626938344463772 PIK3CB 1 GO:0036166 phenotypic switching 1/725 17/18722 0.489157852111702 0.626938344463772 DNMT1 1 GO:0038065 collagen-activated signaling pathway 1/725 17/18722 0.489157852111702 0.626938344463772 COL4A2 1 GO:0042953 lipoprotein transport 1/725 17/18722 0.489157852111702 0.626938344463772 LRP1 1 GO:0043649 dicarboxylic acid catabolic process 1/725 17/18722 0.489157852111702 0.626938344463772 GLUL 1 GO:0043968 histone H2A acetylation 1/725 17/18722 0.489157852111702 0.626938344463772 MORF4L2 1 GO:0044539 long-chain fatty acid import into cell 1/725 17/18722 0.489157852111702 0.626938344463772 SLC27A2 1 GO:0046827 positive regulation of protein export from nucleus 1/725 17/18722 0.489157852111702 0.626938344463772 MDM2 1 GO:0048521 negative regulation of behavior 1/725 17/18722 0.489157852111702 0.626938344463772 ARRDC3 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/725 17/18722 0.489157852111702 0.626938344463772 SYT7 1 GO:0051580 regulation of neurotransmitter uptake 1/725 17/18722 0.489157852111702 0.626938344463772 ITGB1 1 GO:0051797 regulation of hair follicle development 1/725 17/18722 0.489157852111702 0.626938344463772 NUMA1 1 GO:0055119 relaxation of cardiac muscle 1/725 17/18722 0.489157852111702 0.626938344463772 PDE4B 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/725 17/18722 0.489157852111702 0.626938344463772 DHX36 1 GO:0061298 retina vasculature development in camera-type eye 1/725 17/18722 0.489157852111702 0.626938344463772 LRP5 1 GO:0070206 protein trimerization 1/725 17/18722 0.489157852111702 0.626938344463772 MIF 1 GO:0090083 regulation of inclusion body assembly 1/725 17/18722 0.489157852111702 0.626938344463772 HSPA1A 1 GO:0090713 immunological memory process 1/725 17/18722 0.489157852111702 0.626938344463772 CD46 1 GO:0097067 cellular response to thyroid hormone stimulus 1/725 17/18722 0.489157852111702 0.626938344463772 CTSL 1 GO:0140354 lipid import into cell 1/725 17/18722 0.489157852111702 0.626938344463772 SLC27A2 1 GO:1901550 regulation of endothelial cell development 1/725 17/18722 0.489157852111702 0.626938344463772 ROCK1 1 GO:1903140 regulation of establishment of endothelial barrier 1/725 17/18722 0.489157852111702 0.626938344463772 ROCK1 1 GO:1903541 regulation of exosomal secretion 1/725 17/18722 0.489157852111702 0.626938344463772 SDCBP 1 GO:1903830 magnesium ion transmembrane transport 1/725 17/18722 0.489157852111702 0.626938344463772 CNNM2 1 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 3/725 68/18722 0.493278506755938 0.63126199210953 ANXA1/RIPK2/HMGB1 3 GO:0009988 cell-cell recognition 3/725 68/18722 0.493278506755938 0.63126199210953 ALDOA/SPESP1/DLG1 3 GO:0031640 killing of cells of other organism 3/725 68/18722 0.493278506755938 0.63126199210953 GAPDH/SERPINB9/RPS19 3 GO:0034394 protein localization to cell surface 3/725 68/18722 0.493278506755938 0.63126199210953 JAM3/GOPC/RAB11A 3 GO:0042267 natural killer cell mediated cytotoxicity 3/725 68/18722 0.493278506755938 0.63126199210953 SERPINB9/KIF5B/ARL8B 3 GO:0042987 amyloid precursor protein catabolic process 3/725 68/18722 0.493278506755938 0.63126199210953 DHCR24/ROCK1/RTN4 3 GO:0048469 cell maturation 7/725 171/18722 0.494913860691714 0.633194941909716 APP/AKR1B1/TFCP2L1/BCL2/FAM210B/CDKN1A/HES1 7 GO:0002042 cell migration involved in sprouting angiogenesis 4/725 94/18722 0.496268321027642 0.634767630403512 ITGB1/EPHB4/ANXA1/RHOA 4 GO:0033046 negative regulation of sister chromatid segregation 2/725 43/18722 0.500224604437121 0.637575690191542 DUSP1/CENPF 2 GO:0033048 negative regulation of mitotic sister chromatid segregation 2/725 43/18722 0.500224604437121 0.637575690191542 DUSP1/CENPF 2 GO:0033173 calcineurin-NFAT signaling cascade 2/725 43/18722 0.500224604437121 0.637575690191542 NFAT5/SLC9A1 2 GO:0034142 toll-like receptor 4 signaling pathway 2/725 43/18722 0.500224604437121 0.637575690191542 RIPK2/HMGB1 2 GO:0034661 ncRNA catabolic process 2/725 43/18722 0.500224604437121 0.637575690191542 KCNQ1OT1/DICER1 2 GO:0036230 granulocyte activation 2/725 43/18722 0.500224604437121 0.637575690191542 GRN/VAMP2 2 GO:0042181 ketone biosynthetic process 2/725 43/18722 0.500224604437121 0.637575690191542 TPI1/HSD17B1 2 GO:0045776 negative regulation of blood pressure 2/725 43/18722 0.500224604437121 0.637575690191542 ADRB1/GJA5 2 GO:0045840 positive regulation of mitotic nuclear division 2/725 43/18722 0.500224604437121 0.637575690191542 IGF2/LRP5 2 GO:0098927 vesicle-mediated transport between endosomal compartments 2/725 43/18722 0.500224604437121 0.637575690191542 EZR/HOOK3 2 GO:1901381 positive regulation of potassium ion transmembrane transport 2/725 43/18722 0.500224604437121 0.637575690191542 AKAP9/KCNN4 2 GO:1904591 positive regulation of protein import 2/725 43/18722 0.500224604437121 0.637575690191542 CDH1/GLI3 2 GO:2000816 negative regulation of mitotic sister chromatid separation 2/725 43/18722 0.500224604437121 0.637575690191542 DUSP1/CENPF 2 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 2/725 43/18722 0.500224604437121 0.637575690191542 BCL2/HSPA1A 2 GO:0002287 alpha-beta T cell activation involved in immune response 3/725 69/18722 0.503058383670236 0.639109307394697 ANXA1/RIPK2/HMGB1 3 GO:0002293 alpha-beta T cell differentiation involved in immune response 3/725 69/18722 0.503058383670236 0.639109307394697 ANXA1/RIPK2/HMGB1 3 GO:0050805 negative regulation of synaptic transmission 3/725 69/18722 0.503058383670236 0.639109307394697 PPP1R9A/SLC6A4/ARF1 3 GO:0051966 regulation of synaptic transmission, glutamatergic 3/725 69/18722 0.503058383670236 0.639109307394697 EGFR/GLUL/HOMER1 3 GO:0002532 production of molecular mediator involved in inflammatory response 4/725 95/18722 0.504576618260246 0.639109307394697 PDCD4/GRN/RPS19/SERPINE1 4 GO:0042773 ATP synthesis coupled electron transport 4/725 95/18722 0.504576618260246 0.639109307394697 COX6A1/UQCRH/CHCHD2/SDHA 4 GO:0042775 mitochondrial ATP synthesis coupled electron transport 4/725 95/18722 0.504576618260246 0.639109307394697 COX6A1/UQCRH/CHCHD2/SDHA 4 GO:0048709 oligodendrocyte differentiation 4/725 95/18722 0.504576618260246 0.639109307394697 DAG1/GLI3/NF1/HES1 4 GO:0060041 retina development in camera-type eye 6/725 147/18722 0.506495264143383 0.639109307394697 ATP2B1/RPL24/LRP5/SERPINF1/TFAP2A/RDH13 6 GO:1903531 negative regulation of secretion by cell 6/725 147/18722 0.506495264143383 0.639109307394697 GJA1/ANXA1/PPP1R9A/RAB11FIP1/INHA/ERP29 6 GO:0001522 pseudouridine synthesis 1/725 18/18722 0.508957935363187 0.639109307394697 NOP10 1 GO:0001946 lymphangiogenesis 1/725 18/18722 0.508957935363187 0.639109307394697 PTPN14 1 GO:0002501 peptide antigen assembly with MHC protein complex 1/725 18/18722 0.508957935363187 0.639109307394697 B2M 1 GO:0006103 2-oxoglutarate metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 IDH1 1 GO:0006415 translational termination 1/725 18/18722 0.508957935363187 0.639109307394697 EIF5A 1 GO:0006595 polyamine metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 OAZ1 1 GO:0007549 dosage compensation 1/725 18/18722 0.508957935363187 0.639109307394697 CDYL 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 AK3 1 GO:0009404 toxin metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 NFE2L2 1 GO:0015693 magnesium ion transport 1/725 18/18722 0.508957935363187 0.639109307394697 CNNM2 1 GO:0015936 coenzyme A metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 CROT 1 GO:0019184 nonribosomal peptide biosynthetic process 1/725 18/18722 0.508957935363187 0.639109307394697 NFE2L2 1 GO:0019896 axonal transport of mitochondrion 1/725 18/18722 0.508957935363187 0.639109307394697 ARMCX3 1 GO:0021511 spinal cord patterning 1/725 18/18722 0.508957935363187 0.639109307394697 GLI3 1 GO:0030206 chondroitin sulfate biosynthetic process 1/725 18/18722 0.508957935363187 0.639109307394697 CHST12 1 GO:0030728 ovulation 1/725 18/18722 0.508957935363187 0.639109307394697 ADAMTS1 1 GO:0030730 sequestering of triglyceride 1/725 18/18722 0.508957935363187 0.639109307394697 PLIN2 1 GO:0032095 regulation of response to food 1/725 18/18722 0.508957935363187 0.639109307394697 NUCB2 1 GO:0032769 negative regulation of monooxygenase activity 1/725 18/18722 0.508957935363187 0.639109307394697 CAV1 1 GO:0035930 corticosteroid hormone secretion 1/725 18/18722 0.508957935363187 0.639109307394697 C1QTNF1 1 GO:0036507 protein demannosylation 1/725 18/18722 0.508957935363187 0.639109307394697 MAN1A2 1 GO:0036508 protein alpha-1,2-demannosylation 1/725 18/18722 0.508957935363187 0.639109307394697 MAN1A2 1 GO:0042136 neurotransmitter biosynthetic process 1/725 18/18722 0.508957935363187 0.639109307394697 SLC6A4 1 GO:0044872 lipoprotein localization 1/725 18/18722 0.508957935363187 0.639109307394697 LRP1 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/725 18/18722 0.508957935363187 0.639109307394697 ADRB1 1 GO:0045623 negative regulation of T-helper cell differentiation 1/725 18/18722 0.508957935363187 0.639109307394697 ANXA1 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/725 18/18722 0.508957935363187 0.639109307394697 SERPINB9 1 GO:0046040 IMP metabolic process 1/725 18/18722 0.508957935363187 0.639109307394697 PNP 1 GO:0048268 clathrin coat assembly 1/725 18/18722 0.508957935363187 0.639109307394697 CLTC 1 GO:0050665 hydrogen peroxide biosynthetic process 1/725 18/18722 0.508957935363187 0.639109307394697 CYBA 1 GO:0051382 kinetochore assembly 1/725 18/18722 0.508957935363187 0.639109307394697 CENPF 1 GO:0051447 negative regulation of meiotic cell cycle 1/725 18/18722 0.508957935363187 0.639109307394697 DUSP1 1 GO:0051782 negative regulation of cell division 1/725 18/18722 0.508957935363187 0.639109307394697 TXNIP 1 GO:0060192 negative regulation of lipase activity 1/725 18/18722 0.508957935363187 0.639109307394697 ANXA1 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/725 18/18722 0.508957935363187 0.639109307394697 PARP1 1 GO:0060546 negative regulation of necroptotic process 1/725 18/18722 0.508957935363187 0.639109307394697 CAV1 1 GO:0060602 branch elongation of an epithelium 1/725 18/18722 0.508957935363187 0.639109307394697 RDH10 1 GO:0071071 regulation of phospholipid biosynthetic process 1/725 18/18722 0.508957935363187 0.639109307394697 IDH1 1 GO:0071318 cellular response to ATP 1/725 18/18722 0.508957935363187 0.639109307394697 HSP90B1 1 GO:0071786 endoplasmic reticulum tubular network organization 1/725 18/18722 0.508957935363187 0.639109307394697 RTN4 1 GO:0071800 podosome assembly 1/725 18/18722 0.508957935363187 0.639109307394697 RHOA 1 GO:0072079 nephron tubule formation 1/725 18/18722 0.508957935363187 0.639109307394697 IRX2 1 GO:0097094 craniofacial suture morphogenesis 1/725 18/18722 0.508957935363187 0.639109307394697 GLI3 1 GO:0097709 connective tissue replacement 1/725 18/18722 0.508957935363187 0.639109307394697 ROCK1 1 GO:0150078 positive regulation of neuroinflammatory response 1/725 18/18722 0.508957935363187 0.639109307394697 CTSC 1 GO:0150079 negative regulation of neuroinflammatory response 1/725 18/18722 0.508957935363187 0.639109307394697 GRN 1 GO:1904872 regulation of telomerase RNA localization to Cajal body 1/725 18/18722 0.508957935363187 0.639109307394697 NOP10 1 GO:1905820 positive regulation of chromosome separation 1/725 18/18722 0.508957935363187 0.639109307394697 NUMA1 1 GO:2000641 regulation of early endosome to late endosome transport 1/725 18/18722 0.508957935363187 0.639109307394697 EZR 1 GO:0006302 double-strand break repair 10/725 251/18722 0.508992754774589 0.639109307394697 FUS/PRKDC/PARP1/ZSWIM7/RAD50/NIPBL/DEK/UVRAG/SETD2/HMGB1 10 GO:0002066 columnar/cuboidal epithelial cell development 2/725 44/18722 0.512516518454477 0.642646141016353 IL6ST/CDKN1A 2 GO:0007528 neuromuscular junction development 2/725 44/18722 0.512516518454477 0.642646141016353 APP/AFG3L2 2 GO:0042554 superoxide anion generation 2/725 44/18722 0.512516518454477 0.642646141016353 EGFR/CYBA 2 GO:0046006 regulation of activated T cell proliferation 2/725 44/18722 0.512516518454477 0.642646141016353 IGF2/HMGB1 2 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 3/725 70/18722 0.51274034842447 0.642646141016353 TFRC/HSPD1/B2M 3 GO:0003407 neural retina development 3/725 70/18722 0.51274034842447 0.642646141016353 ATP2B1/TFAP2A/RDH13 3 GO:0002718 regulation of cytokine production involved in immune response 4/725 96/18722 0.512823760191586 0.642646141016353 DHX36/CD55/SLC7A5/B2M 4 GO:0051304 chromosome separation 4/725 96/18722 0.512823760191586 0.642646141016353 DUSP1/NEK6/NUMA1/CENPF 4 GO:0072329 monocarboxylic acid catabolic process 5/725 122/18722 0.512951808510356 0.642647730434749 SLC27A2/CROT/LPIN2/HADHA/ECHDC2 5 GO:0007281 germ cell development 11/725 278/18722 0.514343673060119 0.644232290274708 DYNLL1/LGR5/RPS6/NEURL1/JAM3/DIAPH2/BCL2/QKI/CDYL/AFF4/ZFX 11 GO:0002263 cell activation involved in immune response 11/725 279/18722 0.519173699113591 0.650060997143879 LRP1/CD46/APP/TFRC/HSPD1/RPS6/ANXA1/GRN/VAMP2/RIPK2/HMGB1 11 GO:0065004 protein-DNA complex assembly 8/725 201/18722 0.519253694502972 0.650060997143879 NASP/NPM1/ATRX/HP1BP3/BDP1/BRD2/HMGB1/CENPF 8 GO:0001818 negative regulation of cytokine production 14/725 357/18722 0.519433457384812 0.650125480366324 ANXA4/ATP2B1/LGR4/ANXA1/PDCD4/TMSB4X/EZR/DICER1/INHA/SERPINB1/DDIT3/HMGB1/RAC1/ARG2 14 GO:0006690 icosanoid metabolic process 5/725 123/18722 0.520214912504562 0.650398390103317 CYP2J2/MIF/AKR1B1/ANXA1/GPX4 5 GO:0002228 natural killer cell mediated immunity 3/725 71/18722 0.522321274900608 0.650398390103317 SERPINB9/KIF5B/ARL8B 3 GO:0033555 multicellular organismal response to stress 3/725 71/18722 0.522321274900608 0.650398390103317 ADRB1/GJA1/BCL2 3 GO:0045824 negative regulation of innate immune response 3/725 71/18722 0.522321274900608 0.650398390103317 SERPINB9/GRN/RPS19 3 GO:0048285 organelle fission 19/725 488/18722 0.523844786880507 0.650398390103317 RPL24/IGF2/DUSP1/RHOA/LRP5/BMP7/ATRX/RAD50/HSPA1A/NIPBL/KPNB1/CDC42/STAG1/SLC2A8/NEK6/NUMA1/RAB11A/CCSAP/CENPF 19 GO:0002920 regulation of humoral immune response 2/725 45/18722 0.524607422455444 0.650398390103317 CD46/CD55 2 GO:0006903 vesicle targeting 2/725 45/18722 0.524607422455444 0.650398390103317 PDCD6/TRIP11 2 GO:0022602 ovulation cycle process 2/725 45/18722 0.524607422455444 0.650398390103317 HSPA5/ADAMTS1 2 GO:0030835 negative regulation of actin filament depolymerization 2/725 45/18722 0.524607422455444 0.650398390103317 TRIOBP/CAPZB 2 GO:0031670 cellular response to nutrient 2/725 45/18722 0.524607422455444 0.650398390103317 ATP2B1/MDM2 2 GO:0035384 thioester biosynthetic process 2/725 45/18722 0.524607422455444 0.650398390103317 ACSS1/MPC2 2 GO:0042551 neuron maturation 2/725 45/18722 0.524607422455444 0.650398390103317 APP/BCL2 2 GO:0046189 phenol-containing compound biosynthetic process 2/725 45/18722 0.524607422455444 0.650398390103317 OPN3/MFSD12 2 GO:0048599 oocyte development 2/725 45/18722 0.524607422455444 0.650398390103317 BCL2/ZFX 2 GO:0051985 negative regulation of chromosome segregation 2/725 45/18722 0.524607422455444 0.650398390103317 DUSP1/CENPF 2 GO:0071616 acyl-CoA biosynthetic process 2/725 45/18722 0.524607422455444 0.650398390103317 ACSS1/MPC2 2 GO:0098534 centriole assembly 2/725 45/18722 0.524607422455444 0.650398390103317 CEP152/NPM1 2 GO:1905819 negative regulation of chromosome separation 2/725 45/18722 0.524607422455444 0.650398390103317 DUSP1/CENPF 2 GO:0001909 leukocyte mediated cytotoxicity 5/725 124/18722 0.527431535909555 0.650398390103317 SERPINB9/KIF5B/CTSC/ARL8B/B2M 5 GO:0001696 gastric acid secretion 1/725 19/18722 0.527991591097879 0.650398390103317 SGK1 1 GO:0002396 MHC protein complex assembly 1/725 19/18722 0.527991591097879 0.650398390103317 B2M 1 GO:0002483 antigen processing and presentation of endogenous peptide antigen 1/725 19/18722 0.527991591097879 0.650398390103317 B2M 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/725 19/18722 0.527991591097879 0.650398390103317 SERPINB9 1 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 1/725 19/18722 0.527991591097879 0.650398390103317 DHX36 1 GO:0002902 regulation of B cell apoptotic process 1/725 19/18722 0.527991591097879 0.650398390103317 SLC39A10 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/725 19/18722 0.527991591097879 0.650398390103317 ADRB1 1 GO:0006071 glycerol metabolic process 1/725 19/18722 0.527991591097879 0.650398390103317 TPI1 1 GO:0006309 apoptotic DNA fragmentation 1/725 19/18722 0.527991591097879 0.650398390103317 DICER1 1 GO:0006670 sphingosine metabolic process 1/725 19/18722 0.527991591097879 0.650398390103317 PLPP3 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/725 19/18722 0.527991591097879 0.650398390103317 GNAQ 1 GO:0009226 nucleotide-sugar biosynthetic process 1/725 19/18722 0.527991591097879 0.650398390103317 NANS 1 GO:0010544 negative regulation of platelet activation 1/725 19/18722 0.527991591097879 0.650398390103317 C1QTNF1 1 GO:0010738 regulation of protein kinase A signaling 1/725 19/18722 0.527991591097879 0.650398390103317 MIF 1 GO:0019373 epoxygenase P450 pathway 1/725 19/18722 0.527991591097879 0.650398390103317 CYP2J2 1 GO:0030220 platelet formation 1/725 19/18722 0.527991591097879 0.650398390103317 PRKDC 1 GO:0031065 positive regulation of histone deacetylation 1/725 19/18722 0.527991591097879 0.650398390103317 NIPBL 1 GO:0032026 response to magnesium ion 1/725 19/18722 0.527991591097879 0.650398390103317 MDM2 1 GO:0032616 interleukin-13 production 1/725 19/18722 0.527991591097879 0.650398390103317 ARG2 1 GO:0032656 regulation of interleukin-13 production 1/725 19/18722 0.527991591097879 0.650398390103317 ARG2 1 GO:0033194 response to hydroperoxide 1/725 19/18722 0.527991591097879 0.650398390103317 GPX3 1 GO:0035313 wound healing, spreading of epidermal cells 1/725 19/18722 0.527991591097879 0.650398390103317 PHLDB2 1 GO:0035728 response to hepatocyte growth factor 1/725 19/18722 0.527991591097879 0.650398390103317 LGMN 1 GO:0036344 platelet morphogenesis 1/725 19/18722 0.527991591097879 0.650398390103317 PRKDC 1 GO:0043031 negative regulation of macrophage activation 1/725 19/18722 0.527991591097879 0.650398390103317 GRN 1 GO:0043652 engulfment of apoptotic cell 1/725 19/18722 0.527991591097879 0.650398390103317 RAC1 1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/725 19/18722 0.527991591097879 0.650398390103317 MPHOSPH8 1 GO:0045821 positive regulation of glycolytic process 1/725 19/18722 0.527991591097879 0.650398390103317 APP 1 GO:0046033 AMP metabolic process 1/725 19/18722 0.527991591097879 0.650398390103317 AK3 1 GO:0051444 negative regulation of ubiquitin-protein transferase activity 1/725 19/18722 0.527991591097879 0.650398390103317 RPS20 1 GO:0051957 positive regulation of amino acid transport 1/725 19/18722 0.527991591097879 0.650398390103317 ITGB1 1 GO:0060216 definitive hemopoiesis 1/725 19/18722 0.527991591097879 0.650398390103317 TGFBR3 1 GO:0062099 negative regulation of programmed necrotic cell death 1/725 19/18722 0.527991591097879 0.650398390103317 CAV1 1 GO:0070233 negative regulation of T cell apoptotic process 1/725 19/18722 0.527991591097879 0.650398390103317 ARG2 1 GO:0090670 RNA localization to Cajal body 1/725 19/18722 0.527991591097879 0.650398390103317 NOP10 1 GO:0090671 telomerase RNA localization to Cajal body 1/725 19/18722 0.527991591097879 0.650398390103317 NOP10 1 GO:0090672 telomerase RNA localization 1/725 19/18722 0.527991591097879 0.650398390103317 NOP10 1 GO:0090685 RNA localization to nucleus 1/725 19/18722 0.527991591097879 0.650398390103317 NOP10 1 GO:0097501 stress response to metal ion 1/725 19/18722 0.527991591097879 0.650398390103317 HSPA5 1 GO:0097623 potassium ion export across plasma membrane 1/725 19/18722 0.527991591097879 0.650398390103317 DLG1 1 GO:0098780 response to mitochondrial depolarisation 1/725 19/18722 0.527991591097879 0.650398390103317 HUWE1 1 GO:1901659 glycosyl compound biosynthetic process 1/725 19/18722 0.527991591097879 0.650398390103317 PNP 1 GO:1903975 regulation of glial cell migration 1/725 19/18722 0.527991591097879 0.650398390103317 LRP1 1 GO:2000269 regulation of fibroblast apoptotic process 1/725 19/18722 0.527991591097879 0.650398390103317 STK17A 1 GO:2000831 regulation of steroid hormone secretion 1/725 19/18722 0.527991591097879 0.650398390103317 C1QTNF1 1 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 1/725 19/18722 0.527991591097879 0.650398390103317 SOCS1 1 GO:0098813 nuclear chromosome segregation 11/725 281/18722 0.528789989956551 0.651223629516462 DUSP1/DYNC1H1/ATRX/NIPBL/KPNB1/CDC42/STAG1/NEK6/NUMA1/RAB11A/CENPF 11 GO:0002367 cytokine production involved in immune response 4/725 98/18722 0.529125307938181 0.65147830603319 DHX36/CD55/SLC7A5/B2M 4 GO:0006333 chromatin assembly or disassembly 7/725 177/18722 0.531519722951719 0.653791185547746 NASP/NPM1/ATRX/HP1BP3/BRD2/BAZ1B/HMGB1 7 GO:0051648 vesicle localization 7/725 177/18722 0.531519722951719 0.653791185547746 KIF5B/PDCD6/DYNC1H1/TRIP11/RAB11A/RAB1A/ARF1 7 GO:0071466 cellular response to xenobiotic stimulus 7/725 177/18722 0.531519722951719 0.653791185547746 CYP2J2/TFRC/EGFR/NFE2L2/PDE4B/HSPA5/GSTO1 7 GO:0098739 import across plasma membrane 7/725 177/18722 0.531519722951719 0.653791185547746 ITGB1/LRP2/SLC39A10/ARL6IP5/SLC9A1/DLG1/SLC7A5 7 GO:0050709 negative regulation of protein secretion 3/725 72/18722 0.531798271188749 0.653816501735574 ANXA1/RAB11FIP1/ERP29 3 GO:0055021 regulation of cardiac muscle tissue growth 3/725 72/18722 0.531798271188749 0.653816501735574 TGFBR3/GJA1/RBPJ 3 GO:0031497 chromatin assembly 6/725 151/18722 0.532815028864901 0.654907706429724 NASP/NPM1/ATRX/HP1BP3/BRD2/HMGB1 6 GO:0006909 phagocytosis 12/725 308/18722 0.533022505336092 0.655003898072399 ITGB1/LRP1/ITGAV/ANXA1/MET/COLEC12/SYT7/CDC42/HMGB1/RAC1/ARL8B/CYBA 12 GO:0006383 transcription by RNA polymerase III 2/725 46/18722 0.536494434762147 0.658312827356409 DHX36/BDP1 2 GO:0032924 activin receptor signaling pathway 2/725 46/18722 0.536494434762147 0.658312827356409 FSTL3/CSNK2B 2 GO:0035094 response to nicotine 2/725 46/18722 0.536494434762147 0.658312827356409 BCL2/B2M 2 GO:0061028 establishment of endothelial barrier 2/725 46/18722 0.536494434762147 0.658312827356409 EZR/ROCK1 2 GO:0061462 protein localization to lysosome 2/725 46/18722 0.536494434762147 0.658312827356409 HSPA8/RTN4 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/725 46/18722 0.536494434762147 0.658312827356409 SLC39A10/ARG2 2 GO:0003300 cardiac muscle hypertrophy 4/725 99/18722 0.537175374428418 0.658670046680612 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:0021510 spinal cord development 4/725 99/18722 0.537175374428418 0.658670046680612 ISL1/SOX4/GLI3/NF1 4 GO:0051153 regulation of striated muscle cell differentiation 4/725 99/18722 0.537175374428418 0.658670046680612 BCL2/HOPX/MORF4L2/YBX1 4 GO:0048015 phosphatidylinositol-mediated signaling 7/725 178/18722 0.537521830640344 0.658935467839396 EGFR/EZR/NF1/CAT/EXOC1/FLT1/PIK3CB 7 GO:0050848 regulation of calcium-mediated signaling 3/725 73/18722 0.541168672139092 0.662789884629735 CALM1/NFAT5/SLC9A1 3 GO:0061035 regulation of cartilage development 3/725 73/18722 0.541168672139092 0.662789884629735 GLG1/EFEMP1/GLI3 3 GO:0099518 vesicle cytoskeletal trafficking 3/725 73/18722 0.541168672139092 0.662789884629735 KIF5B/DYNC1H1/RAB1A 3 GO:0031929 TOR signaling 5/725 126/18722 0.541718764523772 0.662789884629735 RPS6/GNA12/PDCD6/LARP1/SLC38A9 5 GO:0015850 organic hydroxy compound transport 11/725 284/18722 0.543096106497575 0.662789884629735 CAV1/LRP1/SLC6A4/SYT7/C1QTNF1/PIP4K2A/LY6E/KDM5B/SLC16A3/CYP19A1/ARL8B 11 GO:0007338 single fertilization 6/725 153/18722 0.545753287845933 0.662789884629735 ALDOA/SPESP1/CD46/ASH1L/KDM5B/SNU13 6 GO:0002764 immune response-regulating signaling pathway 18/725 468/18722 0.54620177522765 0.662789884629735 CAV1/LGR4/SLC39A10/HSPD1/KCNN4/EZR/PDE4B/COLEC12/PUM1/BCL2/HSPA1A/HRAS/RTN4/RIPK2/HMGB1/PHPT1/CYBA/CBLB 18 GO:0001832 blastocyst growth 1/725 20/18722 0.546288447027625 0.662789884629735 RTF1 1 GO:0006448 regulation of translational elongation 1/725 20/18722 0.546288447027625 0.662789884629735 EIF5A 1 GO:0006525 arginine metabolic process 1/725 20/18722 0.546288447027625 0.662789884629735 ARG2 1 GO:0006837 serotonin transport 1/725 20/18722 0.546288447027625 0.662789884629735 SLC6A4 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/725 20/18722 0.546288447027625 0.662789884629735 AFG3L2 1 GO:0006883 cellular sodium ion homeostasis 1/725 20/18722 0.546288447027625 0.662789884629735 SLC9A1 1 GO:0007194 negative regulation of adenylate cyclase activity 1/725 20/18722 0.546288447027625 0.662789884629735 AKAP9 1 GO:0007620 copulation 1/725 20/18722 0.546288447027625 0.662789884629735 SLC6A4 1 GO:0009110 vitamin biosynthetic process 1/725 20/18722 0.546288447027625 0.662789884629735 RFK 1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 1/725 20/18722 0.546288447027625 0.662789884629735 UPP1 1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1/725 20/18722 0.546288447027625 0.662789884629735 CALM1 1 GO:0014047 glutamate secretion 1/725 20/18722 0.546288447027625 0.662789884629735 GJA1 1 GO:0016553 base conversion or substitution editing 1/725 20/18722 0.546288447027625 0.662789884629735 RBM47 1 GO:0031645 negative regulation of nervous system process 1/725 20/18722 0.546288447027625 0.662789884629735 CTSC 1 GO:0032211 negative regulation of telomere maintenance via telomerase 1/725 20/18722 0.546288447027625 0.662789884629735 HNRNPA1 1 GO:0032332 positive regulation of chondrocyte differentiation 1/725 20/18722 0.546288447027625 0.662789884629735 GLI3 1 GO:0032495 response to muramyl dipeptide 1/725 20/18722 0.546288447027625 0.662789884629735 RIPK2 1 GO:0039535 regulation of RIG-I signaling pathway 1/725 20/18722 0.546288447027625 0.662789884629735 PUM1 1 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 1/725 20/18722 0.546288447027625 0.662789884629735 MPHOSPH8 1 GO:0043046 DNA methylation involved in gamete generation 1/725 20/18722 0.546288447027625 0.662789884629735 DNMT3A 1 GO:0043651 linoleic acid metabolic process 1/725 20/18722 0.546288447027625 0.662789884629735 CYP2J2 1 GO:0043984 histone H4-K16 acetylation 1/725 20/18722 0.546288447027625 0.662789884629735 PHF20 1 GO:0046485 ether lipid metabolic process 1/725 20/18722 0.546288447027625 0.662789884629735 CHPT1 1 GO:0046629 gamma-delta T cell activation 1/725 20/18722 0.546288447027625 0.662789884629735 SOX4 1 GO:0046931 pore complex assembly 1/725 20/18722 0.546288447027625 0.662789884629735 RTN4 1 GO:0048670 regulation of collateral sprouting 1/725 20/18722 0.546288447027625 0.662789884629735 LRP1 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/725 20/18722 0.546288447027625 0.662789884629735 GJA1 1 GO:0060231 mesenchymal to epithelial transition 1/725 20/18722 0.546288447027625 0.662789884629735 BASP1 1 GO:0061003 positive regulation of dendritic spine morphogenesis 1/725 20/18722 0.546288447027625 0.662789884629735 DHX36 1 GO:0071397 cellular response to cholesterol 1/725 20/18722 0.546288447027625 0.662789884629735 DAG1 1 GO:0071625 vocalization behavior 1/725 20/18722 0.546288447027625 0.662789884629735 GLI3 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/725 20/18722 0.546288447027625 0.662789884629735 CALM1 1 GO:1901679 nucleotide transmembrane transport 1/725 20/18722 0.546288447027625 0.662789884629735 SLC25A36 1 GO:1903817 negative regulation of voltage-gated potassium channel activity 1/725 20/18722 0.546288447027625 0.662789884629735 CAV1 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/725 20/18722 0.546288447027625 0.662789884629735 PKIB 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/725 20/18722 0.546288447027625 0.662789884629735 ZNF451 1 GO:0007595 lactation 2/725 47/18722 0.548175197320562 0.664125256983252 CAV1/NEURL1 2 GO:0045332 phospholipid translocation 2/725 47/18722 0.548175197320562 0.664125256983252 KCNN4/ABCB1 2 GO:0050798 activated T cell proliferation 2/725 47/18722 0.548175197320562 0.664125256983252 IGF2/HMGB1 2 GO:0050885 neuromuscular process controlling balance 2/725 47/18722 0.548175197320562 0.664125256983252 APP/GAA 2 GO:0051972 regulation of telomerase activity 2/725 47/18722 0.548175197320562 0.664125256983252 MAP3K4/PKIB 2 GO:0097300 programmed necrotic cell death 2/725 47/18722 0.548175197320562 0.664125256983252 CAV1/CFLAR 2 GO:0051224 negative regulation of protein transport 5/725 127/18722 0.548786252623045 0.664706694037327 ANXA1/LMAN1/RAB11FIP1/GOPC/ERP29 5 GO:0010822 positive regulation of mitochondrion organization 3/725 74/18722 0.550430031908477 0.66622011264185 PMAIP1/NMT1/CHCHD10 3 GO:0046323 glucose import 3/725 74/18722 0.550430031908477 0.66622011264185 NFE2L2/OPN3/GPC3 3 GO:0046470 phosphatidylcholine metabolic process 3/725 74/18722 0.550430031908477 0.66622011264185 DBI/CHPT1/CDS1 3 GO:0006576 cellular biogenic amine metabolic process 4/725 101/18722 0.553064111440752 0.669248503435945 AKR1B1/OAZ1/MAOA/LY6E 4 GO:0033865 nucleoside bisphosphate metabolic process 5/725 128/18722 0.555801024677497 0.672079053933738 SLC26A2/ACSS1/CROT/TPST2/MPC2 5 GO:0033875 ribonucleoside bisphosphate metabolic process 5/725 128/18722 0.555801024677497 0.672079053933738 SLC26A2/ACSS1/CROT/TPST2/MPC2 5 GO:0034032 purine nucleoside bisphosphate metabolic process 5/725 128/18722 0.555801024677497 0.672079053933738 SLC26A2/ACSS1/CROT/TPST2/MPC2 5 GO:0006836 neurotransmitter transport 8/725 208/18722 0.558345019870631 0.67333155417353 ITGB1/SLC6A8/CALM1/SLC38A1/PPP1R9A/SLC6A4/SYT7/VAMP2 8 GO:0006665 sphingolipid metabolic process 6/725 155/18722 0.558530485701368 0.67333155417353 ORMDL1/PLPP3/HACD3/PSAP/HEXA/SPTSSA 6 GO:0002673 regulation of acute inflammatory response 2/725 48/18722 0.559647839569659 0.67333155417353 IL6ST/ASH1L 2 GO:0002686 negative regulation of leukocyte migration 2/725 48/18722 0.559647839569659 0.67333155417353 MIF/DUSP1 2 GO:0033628 regulation of cell adhesion mediated by integrin 2/725 48/18722 0.559647839569659 0.67333155417353 JAM3/SERPINE1 2 GO:0035036 sperm-egg recognition 2/725 48/18722 0.559647839569659 0.67333155417353 ALDOA/SPESP1 2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 2/725 48/18722 0.559647839569659 0.67333155417353 ATRX/BOD1L1 2 GO:0090311 regulation of protein deacetylation 2/725 48/18722 0.559647839569659 0.67333155417353 NIPBL/KDM5A 2 GO:0097720 calcineurin-mediated signaling 2/725 48/18722 0.559647839569659 0.67333155417353 NFAT5/SLC9A1 2 GO:1902003 regulation of amyloid-beta formation 2/725 48/18722 0.559647839569659 0.67333155417353 ROCK1/RTN4 2 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2/725 48/18722 0.559647839569659 0.67333155417353 EIF3H/SDCBP 2 GO:0006672 ceramide metabolic process 4/725 102/18722 0.560899127726251 0.67333155417353 ORMDL1/PLPP3/HEXA/SPTSSA 4 GO:0014897 striated muscle hypertrophy 4/725 102/18722 0.560899127726251 0.67333155417353 PARP1/IL6ST/ROCK1/SLC9A1 4 GO:1990542 mitochondrial transmembrane transport 4/725 102/18722 0.560899127726251 0.67333155417353 HSPD1/SLC25A36/AFG3L2/MPC2 4 GO:0048017 inositol lipid-mediated signaling 7/725 182/18722 0.561209079369561 0.67333155417353 EGFR/EZR/NF1/CAT/EXOC1/FLT1/PIK3CB 7 GO:0006334 nucleosome assembly 5/725 129/18722 0.562761690349116 0.67333155417353 NASP/NPM1/ATRX/HP1BP3/BRD2 5 GO:0003091 renal water homeostasis 1/725 21/18722 0.563876987071737 0.67333155417353 AKR1B1 1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 1/725 21/18722 0.563876987071737 0.67333155417353 COX6A1 1 GO:0006353 DNA-templated transcription, termination 1/725 21/18722 0.563876987071737 0.67333155417353 POLR2A 1 GO:0007063 regulation of sister chromatid cohesion 1/725 21/18722 0.563876987071737 0.67333155417353 ATRX 1 GO:0007252 I-kappaB phosphorylation 1/725 21/18722 0.563876987071737 0.67333155417353 ERC1 1 GO:0007617 mating behavior 1/725 21/18722 0.563876987071737 0.67333155417353 APP 1 GO:0009067 aspartate family amino acid biosynthetic process 1/725 21/18722 0.563876987071737 0.67333155417353 MTR 1 GO:0010988 regulation of low-density lipoprotein particle clearance 1/725 21/18722 0.563876987071737 0.67333155417353 MYLIP 1 GO:0019985 translesion synthesis 1/725 21/18722 0.563876987071737 0.67333155417353 USP10 1 GO:0023019 signal transduction involved in regulation of gene expression 1/725 21/18722 0.563876987071737 0.67333155417353 PARP1 1 GO:0033962 P-body assembly 1/725 21/18722 0.563876987071737 0.67333155417353 DYNC1H1 1 GO:0035020 regulation of Rac protein signal transduction 1/725 21/18722 0.563876987071737 0.67333155417353 PIK3CB 1 GO:0035330 regulation of hippo signaling 1/725 21/18722 0.563876987071737 0.67333155417353 DLG5 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/725 21/18722 0.563876987071737 0.67333155417353 CTSL 1 GO:0044342 type B pancreatic cell proliferation 1/725 21/18722 0.563876987071737 0.67333155417353 SERPINB1 1 GO:0045655 regulation of monocyte differentiation 1/725 21/18722 0.563876987071737 0.67333155417353 JUN 1 GO:0046128 purine ribonucleoside metabolic process 1/725 21/18722 0.563876987071737 0.67333155417353 PNP 1 GO:0046514 ceramide catabolic process 1/725 21/18722 0.563876987071737 0.67333155417353 HEXA 1 GO:0046519 sphingoid metabolic process 1/725 21/18722 0.563876987071737 0.67333155417353 PLPP3 1 GO:0046597 negative regulation of viral entry into host cell 1/725 21/18722 0.563876987071737 0.67333155417353 LY6E 1 GO:0046599 regulation of centriole replication 1/725 21/18722 0.563876987071737 0.67333155417353 NPM1 1 GO:0048199 vesicle targeting, to, from or within Golgi 1/725 21/18722 0.563876987071737 0.67333155417353 PDCD6 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/725 21/18722 0.563876987071737 0.67333155417353 DAG1 1 GO:0050802 circadian sleep/wake cycle, sleep 1/725 21/18722 0.563876987071737 0.67333155417353 ADRB1 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/725 21/18722 0.563876987071737 0.67333155417353 ENG 1 GO:0060117 auditory receptor cell development 1/725 21/18722 0.563876987071737 0.67333155417353 TRIOBP 1 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 1/725 21/18722 0.563876987071737 0.67333155417353 DHX36 1 GO:0070584 mitochondrion morphogenesis 1/725 21/18722 0.563876987071737 0.67333155417353 PLEC 1 GO:0071605 monocyte chemotactic protein-1 production 1/725 21/18722 0.563876987071737 0.67333155417353 HMGB1 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/725 21/18722 0.563876987071737 0.67333155417353 HMGB1 1 GO:0097062 dendritic spine maintenance 1/725 21/18722 0.563876987071737 0.67333155417353 HOMER1 1 GO:0098719 sodium ion import across plasma membrane 1/725 21/18722 0.563876987071737 0.67333155417353 SLC9A1 1 GO:0099515 actin filament-based transport 1/725 21/18722 0.563876987071737 0.67333155417353 SYNE2 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/725 21/18722 0.563876987071737 0.67333155417353 VAMP2 1 GO:1903429 regulation of cell maturation 1/725 21/18722 0.563876987071737 0.67333155417353 BCL2 1 GO:1905209 positive regulation of cardiocyte differentiation 1/725 21/18722 0.563876987071737 0.67333155417353 DHX36 1 GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 1/725 21/18722 0.563876987071737 0.67333155417353 ABCB1 1 GO:0046395 carboxylic acid catabolic process 9/725 236/18722 0.5663598552388 0.676137095196768 GLDC/SLC27A2/CROT/LPIN2/GLUL/NAGK/HADHA/ECHDC2/ARG2 9 GO:0030148 sphingolipid biosynthetic process 4/725 103/18722 0.568658989264513 0.678722019444742 ORMDL1/PLPP3/HACD3/SPTSSA 4 GO:0015918 sterol transport 5/725 130/18722 0.569666925267118 0.67948992175255 CAV1/LRP1/SYT7/PIP4K2A/ARL8B 5 GO:0000959 mitochondrial RNA metabolic process 2/725 49/18722 0.570910944317244 0.67948992175255 TFAM/CHCHD10 2 GO:0001913 T cell mediated cytotoxicity 2/725 49/18722 0.570910944317244 0.67948992175255 CTSC/B2M 2 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 2/725 49/18722 0.570910944317244 0.67948992175255 TFRC/HSPD1 2 GO:0002208 somatic diversification of immunoglobulins involved in immune response 2/725 49/18722 0.570910944317244 0.67948992175255 TFRC/HSPD1 2 GO:0008038 neuron recognition 2/725 49/18722 0.570910944317244 0.67948992175255 APP/RTN4 2 GO:0021695 cerebellar cortex development 2/725 49/18722 0.570910944317244 0.67948992175255 HSPA5/RERE 2 GO:0043457 regulation of cellular respiration 2/725 49/18722 0.570910944317244 0.67948992175255 RHOA/OPN3 2 GO:0045190 isotype switching 2/725 49/18722 0.570910944317244 0.67948992175255 TFRC/HSPD1 2 GO:0050832 defense response to fungus 2/725 49/18722 0.570910944317244 0.67948992175255 GAPDH/S100A9 2 GO:0051932 synaptic transmission, GABAergic 2/725 49/18722 0.570910944317244 0.67948992175255 KIF5B/GABRE 2 GO:1901799 negative regulation of proteasomal protein catabolic process 2/725 49/18722 0.570910944317244 0.67948992175255 EIF3H/SDCBP 2 GO:0042180 cellular ketone metabolic process 8/725 211/18722 0.574681563626528 0.683817100005369 TPI1/CAV1/CYP11A1/AKR1B1/ANXA1/NMT1/RDH10/HSD17B1 8 GO:0006661 phosphatidylinositol biosynthetic process 5/725 131/18722 0.576515470211816 0.684969081982489 SOCS1/TMEM150A/CDS1/PIP4K2A/PIK3CB 5 GO:1904950 negative regulation of establishment of protein localization 5/725 131/18722 0.576515470211816 0.684969081982489 ANXA1/LMAN1/RAB11FIP1/GOPC/ERP29 5 GO:0010827 regulation of glucose transmembrane transport 3/725 77/18722 0.577538539341927 0.684969081982489 NFE2L2/OPN3/GPC3 3 GO:0051607 defense response to virus 10/725 265/18722 0.578509276440952 0.684969081982489 PMAIP1/NCBP3/BNIP3L/TRIM44/DHX36/PUM1/BCL2/DDX17/EXOC1/SETD2 10 GO:0140546 defense response to symbiont 10/725 265/18722 0.578509276440952 0.684969081982489 PMAIP1/NCBP3/BNIP3L/TRIM44/DHX36/PUM1/BCL2/DDX17/EXOC1/SETD2 10 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 1/725 22/18722 0.580784595454871 0.684969081982489 APELA 1 GO:0002053 positive regulation of mesenchymal cell proliferation 1/725 22/18722 0.580784595454871 0.684969081982489 LRP5 1 GO:0006359 regulation of transcription by RNA polymerase III 1/725 22/18722 0.580784595454871 0.684969081982489 DHX36 1 GO:0006379 mRNA cleavage 1/725 22/18722 0.580784595454871 0.684969081982489 AGO2 1 GO:0006662 glycerol ether metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 CHPT1 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/725 22/18722 0.580784595454871 0.684969081982489 SPESP1 1 GO:0007413 axonal fasciculation 1/725 22/18722 0.580784595454871 0.684969081982489 RTN4 1 GO:0008211 glucocorticoid metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 CYP11A1 1 GO:0009220 pyrimidine ribonucleotide biosynthetic process 1/725 22/18722 0.580784595454871 0.684969081982489 UPP1 1 GO:0010310 regulation of hydrogen peroxide metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 RAC1 1 GO:0016137 glycoside metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 AKR1B1 1 GO:0021854 hypothalamus development 1/725 22/18722 0.580784595454871 0.684969081982489 NRP2 1 GO:0021904 dorsal/ventral neural tube patterning 1/725 22/18722 0.580784595454871 0.684969081982489 GLI3 1 GO:0022401 negative adaptation of signaling pathway 1/725 22/18722 0.580784595454871 0.684969081982489 APELA 1 GO:0022616 DNA strand elongation 1/725 22/18722 0.580784595454871 0.684969081982489 RAD50 1 GO:0031061 negative regulation of histone methylation 1/725 22/18722 0.580784595454871 0.684969081982489 DNMT1 1 GO:0032098 regulation of appetite 1/725 22/18722 0.580784595454871 0.684969081982489 NUCB2 1 GO:0032891 negative regulation of organic acid transport 1/725 22/18722 0.580784595454871 0.684969081982489 ARL6IP5 1 GO:0035809 regulation of urine volume 1/725 22/18722 0.580784595454871 0.684969081982489 AKR1B1 1 GO:0042749 regulation of circadian sleep/wake cycle 1/725 22/18722 0.580784595454871 0.684969081982489 ADRB1 1 GO:0043486 histone exchange 1/725 22/18722 0.580784595454871 0.684969081982489 NASP 1 GO:0044346 fibroblast apoptotic process 1/725 22/18722 0.580784595454871 0.684969081982489 STK17A 1 GO:0045048 protein insertion into ER membrane 1/725 22/18722 0.580784595454871 0.684969081982489 CCDC47 1 GO:0045061 thymic T cell selection 1/725 22/18722 0.580784595454871 0.684969081982489 GLI3 1 GO:0045663 positive regulation of myoblast differentiation 1/725 22/18722 0.580784595454871 0.684969081982489 IGFBP3 1 GO:0046058 cAMP metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 PDE4B 1 GO:0046628 positive regulation of insulin receptor signaling pathway 1/725 22/18722 0.580784595454871 0.684969081982489 IGF2 1 GO:0061042 vascular wound healing 1/725 22/18722 0.580784595454871 0.684969081982489 SERPINE1 1 GO:0071404 cellular response to low-density lipoprotein particle stimulus 1/725 22/18722 0.580784595454871 0.684969081982489 ITGB1 1 GO:0071467 cellular response to pH 1/725 22/18722 0.580784595454871 0.684969081982489 SLC9A1 1 GO:0106030 neuron projection fasciculation 1/725 22/18722 0.580784595454871 0.684969081982489 RTN4 1 GO:1900543 negative regulation of purine nucleotide metabolic process 1/725 22/18722 0.580784595454871 0.684969081982489 PARP1 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/725 22/18722 0.580784595454871 0.684969081982489 APELA 1 GO:0007080 mitotic metaphase plate congression 2/725 50/18722 0.581963515521587 0.686040246553238 KPNB1/RAB11A 2 GO:0099054 presynapse assembly 2/725 50/18722 0.581963515521587 0.686040246553238 APP/SDCBP 2 GO:0001505 regulation of neurotransmitter levels 8/725 213/18722 0.58541816692463 0.689952264157394 ITGB1/CALM1/SLC38A1/PPP1R9A/SLC6A4/MAOA/SYT7/VAMP2 8 GO:0009064 glutamine family amino acid metabolic process 3/725 78/18722 0.586343402560525 0.690721521631257 GLUL/RIMKLB/ARG2 3 GO:0043537 negative regulation of blood vessel endothelial cell migration 3/725 78/18722 0.586343402560525 0.690721521631257 RHOA/CSNK2B/HMGB1 3 GO:0016054 organic acid catabolic process 9/725 240/18722 0.586693898127847 0.690813326274113 GLDC/SLC27A2/CROT/LPIN2/GLUL/NAGK/HADHA/ECHDC2/ARG2 9 GO:0050851 antigen receptor-mediated signaling pathway 9/725 240/18722 0.586693898127847 0.690813326274113 SLC39A10/KCNN4/EZR/PDE4B/BCL2/HRAS/RIPK2/PHPT1/CBLB 9 GO:0009855 determination of bilateral symmetry 5/725 133/18722 0.59003777382773 0.694589288326234 GALNT11/TBX3/MIB1/DDIT3/ENG 5 GO:0010874 regulation of cholesterol efflux 2/725 51/18722 0.592804947882754 0.696040384055541 CAV1/LRP1 2 GO:0045668 negative regulation of osteoblast differentiation 2/725 51/18722 0.592804947882754 0.696040384055541 CRIM1/LRP5 2 GO:0071622 regulation of granulocyte chemotaxis 2/725 51/18722 0.592804947882754 0.696040384055541 JAM3/RAC1 2 GO:1903307 positive regulation of regulated secretory pathway 2/725 51/18722 0.592804947882754 0.696040384055541 SYT7/ARF1 2 GO:0001895 retina homeostasis 3/725 79/18722 0.595030026146983 0.696040384055541 HSPB1/ACTG1/B2M 3 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 3/725 79/18722 0.595030026146983 0.696040384055541 GAPDH/S100A9/RPS19 3 GO:0048839 inner ear development 7/725 188/18722 0.595674800148797 0.696040384055541 LGR5/RBPJ/TRIOBP/GLI3/TRIP11/TFAP2A/HES1 7 GO:0002705 positive regulation of leukocyte mediated immunity 5/725 134/18722 0.596709331816815 0.696040384055541 TFRC/HSPD1/DHX36/CD55/B2M 5 GO:0009799 specification of symmetry 5/725 134/18722 0.596709331816815 0.696040384055541 GALNT11/TBX3/MIB1/DDIT3/ENG 5 GO:0002052 positive regulation of neuroblast proliferation 1/725 23/18722 0.597037599107022 0.696040384055541 GLI3 1 GO:0002082 regulation of oxidative phosphorylation 1/725 23/18722 0.597037599107022 0.696040384055541 RHOA 1 GO:0006541 glutamine metabolic process 1/725 23/18722 0.597037599107022 0.696040384055541 GLUL 1 GO:0006622 protein targeting to lysosome 1/725 23/18722 0.597037599107022 0.696040384055541 HSPA8 1 GO:0006929 substrate-dependent cell migration 1/725 23/18722 0.597037599107022 0.696040384055541 SDCBP 1 GO:0010888 negative regulation of lipid storage 1/725 23/18722 0.597037599107022 0.696040384055541 ITGAV 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/725 23/18722 0.597037599107022 0.696040384055541 CLDN4 1 GO:0016578 histone deubiquitination 1/725 23/18722 0.597037599107022 0.696040384055541 USP22 1 GO:0016973 poly(A)+ mRNA export from nucleus 1/725 23/18722 0.597037599107022 0.696040384055541 PABPN1 1 GO:0021544 subpallium development 1/725 23/18722 0.597037599107022 0.696040384055541 GLI3 1 GO:0021884 forebrain neuron development 1/725 23/18722 0.597037599107022 0.696040384055541 NRP2 1 GO:0023058 adaptation of signaling pathway 1/725 23/18722 0.597037599107022 0.696040384055541 APELA 1 GO:0031280 negative regulation of cyclase activity 1/725 23/18722 0.597037599107022 0.696040384055541 AKAP9 1 GO:0032740 positive regulation of interleukin-17 production 1/725 23/18722 0.597037599107022 0.696040384055541 SLC7A5 1 GO:0034695 response to prostaglandin E 1/725 23/18722 0.597037599107022 0.696040384055541 TGFBR3 1 GO:0035162 embryonic hemopoiesis 1/725 23/18722 0.597037599107022 0.696040384055541 PBX1 1 GO:0035929 steroid hormone secretion 1/725 23/18722 0.597037599107022 0.696040384055541 C1QTNF1 1 GO:0035988 chondrocyte proliferation 1/725 23/18722 0.597037599107022 0.696040384055541 GOLGB1 1 GO:0043931 ossification involved in bone maturation 1/725 23/18722 0.597037599107022 0.696040384055541 RHOA 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/725 23/18722 0.597037599107022 0.696040384055541 ANXA1 1 GO:0045932 negative regulation of muscle contraction 1/725 23/18722 0.597037599107022 0.696040384055541 SRI 1 GO:0045980 negative regulation of nucleotide metabolic process 1/725 23/18722 0.597037599107022 0.696040384055541 PARP1 1 GO:0046618 xenobiotic export 1/725 23/18722 0.597037599107022 0.696040384055541 ABCB1 1 GO:0050765 negative regulation of phagocytosis 1/725 23/18722 0.597037599107022 0.696040384055541 HMGB1 1 GO:0051383 kinetochore organization 1/725 23/18722 0.597037599107022 0.696040384055541 CENPF 1 GO:0051590 positive regulation of neurotransmitter transport 1/725 23/18722 0.597037599107022 0.696040384055541 ITGB1 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/725 23/18722 0.597037599107022 0.696040384055541 GDF15 1 GO:0060384 innervation 1/725 23/18722 0.597037599107022 0.696040384055541 ISL1 1 GO:0060487 lung epithelial cell differentiation 1/725 23/18722 0.597037599107022 0.696040384055541 RBPJ 1 GO:0060547 negative regulation of necrotic cell death 1/725 23/18722 0.597037599107022 0.696040384055541 CAV1 1 GO:0071218 cellular response to misfolded protein 1/725 23/18722 0.597037599107022 0.696040384055541 DNAJB14 1 GO:0071305 cellular response to vitamin D 1/725 23/18722 0.597037599107022 0.696040384055541 ATP2B1 1 GO:0090335 regulation of brown fat cell differentiation 1/725 23/18722 0.597037599107022 0.696040384055541 BMP7 1 GO:0032526 response to retinoic acid 4/725 107/18722 0.598917314889892 0.698071250672996 DUSP1/GJA1/SLC6A4/SERPINF1 4 GO:0042157 lipoprotein metabolic process 5/725 135/18722 0.60331979653018 0.702852023353147 LRP1/ITGAV/DBI/GLUL/NMT1 5 GO:0002218 activation of innate immune response 2/725 52/18722 0.60343499815208 0.702852023353147 PRKDC/HMGB1 2 GO:0034204 lipid translocation 2/725 52/18722 0.60343499815208 0.702852023353147 KCNN4/ABCB1 2 GO:0002832 negative regulation of response to biotic stimulus 4/725 108/18722 0.606280110245987 0.705841497206456 SERPINB9/GRN/RPS19/ARG2 4 GO:0022037 metencephalon development 4/725 108/18722 0.606280110245987 0.705841497206456 HSPA5/BCL2/RERE/SEMA4C 4 GO:0000422 autophagy of mitochondrion 3/725 81/18722 0.612043584942254 0.707743886152299 BNIP3L/HUWE1/MAP1LC3B 3 GO:0008589 regulation of smoothened signaling pathway 3/725 81/18722 0.612043584942254 0.707743886152299 DLG5/GLI3/GPC3 3 GO:0061726 mitochondrion disassembly 3/725 81/18722 0.612043584942254 0.707743886152299 BNIP3L/HUWE1/MAP1LC3B 3 GO:2000243 positive regulation of reproductive process 3/725 81/18722 0.612043584942254 0.707743886152299 SYDE1/APELA/AGO2 3 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/725 24/18722 0.612661308430911 0.707743886152299 RPS21 1 GO:0001779 natural killer cell differentiation 1/725 24/18722 0.612661308430911 0.707743886152299 PBX1 1 GO:0001783 B cell apoptotic process 1/725 24/18722 0.612661308430911 0.707743886152299 SLC39A10 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/725 24/18722 0.612661308430911 0.707743886152299 SERPINB9 1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 1/725 24/18722 0.612661308430911 0.707743886152299 HSPD1 1 GO:0006213 pyrimidine nucleoside metabolic process 1/725 24/18722 0.612661308430911 0.707743886152299 UPP1 1 GO:0010155 regulation of proton transport 1/725 24/18722 0.612661308430911 0.707743886152299 TMSB4X 1 GO:0022410 circadian sleep/wake cycle process 1/725 24/18722 0.612661308430911 0.707743886152299 ADRB1 1 GO:0032528 microvillus organization 1/725 24/18722 0.612661308430911 0.707743886152299 EZR 1 GO:0036010 protein localization to endosome 1/725 24/18722 0.612661308430911 0.707743886152299 EZR 1 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 1/725 24/18722 0.612661308430911 0.707743886152299 PUM1 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/725 24/18722 0.612661308430911 0.707743886152299 IGFBP3 1 GO:0044321 response to leptin 1/725 24/18722 0.612661308430911 0.707743886152299 LRP2 1 GO:0045649 regulation of macrophage differentiation 1/725 24/18722 0.612661308430911 0.707743886152299 INHA 1 GO:0050855 regulation of B cell receptor signaling pathway 1/725 24/18722 0.612661308430911 0.707743886152299 SLC39A10 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/725 24/18722 0.612661308430911 0.707743886152299 HMGB1 1 GO:0051156 glucose 6-phosphate metabolic process 1/725 24/18722 0.612661308430911 0.707743886152299 RPIA 1 GO:0051923 sulfation 1/725 24/18722 0.612661308430911 0.707743886152299 TPST2 1 GO:0060479 lung cell differentiation 1/725 24/18722 0.612661308430911 0.707743886152299 RBPJ 1 GO:0070841 inclusion body assembly 1/725 24/18722 0.612661308430911 0.707743886152299 HSPA1A 1 GO:0071294 cellular response to zinc ion 1/725 24/18722 0.612661308430911 0.707743886152299 PARP1 1 GO:0071577 zinc ion transmembrane transport 1/725 24/18722 0.612661308430911 0.707743886152299 SLC39A10 1 GO:0071676 negative regulation of mononuclear cell migration 1/725 24/18722 0.612661308430911 0.707743886152299 DUSP1 1 GO:0090023 positive regulation of neutrophil chemotaxis 1/725 24/18722 0.612661308430911 0.707743886152299 RAC1 1 GO:0120255 olefinic compound biosynthetic process 1/725 24/18722 0.612661308430911 0.707743886152299 HSD17B1 1 GO:1901984 negative regulation of protein acetylation 1/725 24/18722 0.612661308430911 0.707743886152299 ZNF451 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/725 24/18722 0.612661308430911 0.707743886152299 CYBA 1 GO:2000310 regulation of NMDA receptor activity 1/725 24/18722 0.612661308430911 0.707743886152299 APP 1 GO:2000353 positive regulation of endothelial cell apoptotic process 1/725 24/18722 0.612661308430911 0.707743886152299 PDCD4 1 GO:2000679 positive regulation of transcription regulatory region DNA binding 1/725 24/18722 0.612661308430911 0.707743886152299 PARP1 1 GO:0002700 regulation of production of molecular mediator of immune response 6/725 164/18722 0.61380706309744 0.708475569141655 TFRC/PRKDC/DHX36/CD55/SLC7A5/B2M 6 GO:0034381 plasma lipoprotein particle clearance 2/725 53/18722 0.613853758072628 0.708475569141655 LRPAP1/MYLIP 2 GO:0097479 synaptic vesicle localization 2/725 53/18722 0.613853758072628 0.708475569141655 KIF5B/ARF1 2 GO:0099172 presynapse organization 2/725 53/18722 0.613853758072628 0.708475569141655 APP/SDCBP 2 GO:0071805 potassium ion transmembrane transport 8/725 219/18722 0.616827714306932 0.711745887507816 AKAP9/CAV1/ITGB1/CD63/KCNN4/SLC9A1/DLG1/VAMP2 8 GO:0007286 spermatid development 6/725 165/18722 0.619706344440887 0.714904747376162 DYNLL1/NEURL1/JAM3/QKI/CDYL/AFF4 6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 3/725 82/18722 0.62036844967951 0.715505727286789 RPS21/DICER1/AGO2 3 GO:0000724 double-strand break repair via homologous recombination 5/725 138/18722 0.622775454042178 0.718118466000865 FUS/PARP1/ZSWIM7/NIPBL/SETD2 5 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2/725 54/18722 0.624061628867599 0.718705716375936 CD46/CD55 2 GO:0014888 striated muscle adaptation 2/725 54/18722 0.624061628867599 0.718705716375936 CAMK2G/CFLAR 2 GO:0030834 regulation of actin filament depolymerization 2/725 54/18722 0.624061628867599 0.718705716375936 TRIOBP/CAPZB 2 GO:0070228 regulation of lymphocyte apoptotic process 2/725 54/18722 0.624061628867599 0.718705716375936 SLC39A10/ARG2 2 GO:0006312 mitotic recombination 1/725 25/18722 0.627680056499559 0.718705716375936 RAD50 1 GO:0007274 neuromuscular synaptic transmission 1/725 25/18722 0.627680056499559 0.718705716375936 ERC1 1 GO:0007288 sperm axoneme assembly 1/725 25/18722 0.627680056499559 0.718705716375936 NEURL1 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/725 25/18722 0.627680056499559 0.718705716375936 AK3 1 GO:0010954 positive regulation of protein processing 1/725 25/18722 0.627680056499559 0.718705716375936 ENO1 1 GO:0010996 response to auditory stimulus 1/725 25/18722 0.627680056499559 0.718705716375936 USP53 1 GO:0032104 regulation of response to extracellular stimulus 1/725 25/18722 0.627680056499559 0.718705716375936 NUCB2 1 GO:0032107 regulation of response to nutrient levels 1/725 25/18722 0.627680056499559 0.718705716375936 NUCB2 1 GO:0032331 negative regulation of chondrocyte differentiation 1/725 25/18722 0.627680056499559 0.718705716375936 EFEMP1 1 GO:0033233 regulation of protein sumoylation 1/725 25/18722 0.627680056499559 0.718705716375936 HMG20B 1 GO:0033622 integrin activation 1/725 25/18722 0.627680056499559 0.718705716375936 JAM3 1 GO:0036315 cellular response to sterol 1/725 25/18722 0.627680056499559 0.718705716375936 DAG1 1 GO:0042832 defense response to protozoan 1/725 25/18722 0.627680056499559 0.718705716375936 HRAS 1 GO:0045109 intermediate filament organization 1/725 25/18722 0.627680056499559 0.718705716375936 PLEC 1 GO:0045324 late endosome to vacuole transport 1/725 25/18722 0.627680056499559 0.718705716375936 LEPROTL1 1 GO:0045822 negative regulation of heart contraction 1/725 25/18722 0.627680056499559 0.718705716375936 SRI 1 GO:0046835 carbohydrate phosphorylation 1/725 25/18722 0.627680056499559 0.718705716375936 NAGK 1 GO:0050927 positive regulation of positive chemotaxis 1/725 25/18722 0.627680056499559 0.718705716375936 PGF 1 GO:0051204 protein insertion into mitochondrial membrane 1/725 25/18722 0.627680056499559 0.718705716375936 NMT1 1 GO:0051788 response to misfolded protein 1/725 25/18722 0.627680056499559 0.718705716375936 DNAJB14 1 GO:0060740 prostate gland epithelium morphogenesis 1/725 25/18722 0.627680056499559 0.718705716375936 BMP7 1 GO:0070199 establishment of protein localization to chromosome 1/725 25/18722 0.627680056499559 0.718705716375936 NIPBL 1 GO:0072202 cell differentiation involved in metanephros development 1/725 25/18722 0.627680056499559 0.718705716375936 LGR4 1 GO:0090312 positive regulation of protein deacetylation 1/725 25/18722 0.627680056499559 0.718705716375936 NIPBL 1 GO:0099560 synaptic membrane adhesion 1/725 25/18722 0.627680056499559 0.718705716375936 PTPRF 1 GO:0120316 sperm flagellum assembly 1/725 25/18722 0.627680056499559 0.718705716375936 NEURL1 1 GO:1905563 negative regulation of vascular endothelial cell proliferation 1/725 25/18722 0.627680056499559 0.718705716375936 FLT1 1 GO:0002285 lymphocyte activation involved in immune response 7/725 194/18722 0.628709955504173 0.71955989262828 CD46/TFRC/HSPD1/RPS6/ANXA1/RIPK2/HMGB1 7 GO:0050777 negative regulation of immune response 7/725 194/18722 0.628709955504173 0.71955989262828 SERPINB9/CD46/ANXA1/GRN/RPS19/CD55/ARG2 7 GO:0019216 regulation of lipid metabolic process 12/725 331/18722 0.633533697838251 0.724917000980157 CAV1/ORMDL1/SF1/ANXA1/EDF1/IDH1/PSAP/RDH10/CDC42/PIP4K2A/ARF1/FLT1 12 GO:0048016 inositol phosphate-mediated signaling 2/725 55/18722 0.634059297197676 0.725191014777757 NFAT5/SLC9A1 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/725 55/18722 0.634059297197676 0.725191014777757 ROCK1/RTN4 2 GO:0001676 long-chain fatty acid metabolic process 4/725 112/18722 0.634892316264624 0.72597995739801 CYP2J2/SLC27A2/GPX4/QKI 4 GO:0000725 recombinational repair 5/725 140/18722 0.635424621269124 0.726260970735781 FUS/PARP1/ZSWIM7/NIPBL/SETD2 5 GO:0015748 organophosphate ester transport 5/725 140/18722 0.635424621269124 0.726260970735781 GJA1/KCNN4/ABCB1/DBI/SLC25A36 5 GO:0015844 monoamine transport 3/725 84/18722 0.636650344784004 0.727170031029769 SLC6A4/SYT7/LY6E 3 GO:0042440 pigment metabolic process 3/725 84/18722 0.636650344784004 0.727170031029769 OPN3/BCL2/MFSD12 3 GO:0098586 cellular response to virus 3/725 84/18722 0.636650344784004 0.727170031029769 PUM1/EIF5A/ARF1 3 GO:0006310 DNA recombination 11/725 305/18722 0.638126882062219 0.728326756110399 HMGB3/TFRC/FUS/HSPD1/PRKDC/PARP1/ZSWIM7/RAD50/NIPBL/SETD2/HMGB1 11 GO:0001578 microtubule bundle formation 4/725 113/18722 0.641831451206182 0.728326756110399 CLIP1/CAPN6/NEURL1/NUMA1 4 GO:0002708 positive regulation of lymphocyte mediated immunity 4/725 113/18722 0.641831451206182 0.728326756110399 TFRC/HSPD1/CD55/B2M 4 GO:0044106 cellular amine metabolic process 4/725 113/18722 0.641831451206182 0.728326756110399 AKR1B1/OAZ1/MAOA/LY6E 4 GO:0001562 response to protozoan 1/725 26/18722 0.642117236744402 0.728326756110399 HRAS 1 GO:0001573 ganglioside metabolic process 1/725 26/18722 0.642117236744402 0.728326756110399 HEXA 1 GO:0001963 synaptic transmission, dopaminergic 1/725 26/18722 0.642117236744402 0.728326756110399 SLC6A4 1 GO:0002407 dendritic cell chemotaxis 1/725 26/18722 0.642117236744402 0.728326756110399 HMGB1 1 GO:0006027 glycosaminoglycan catabolic process 1/725 26/18722 0.642117236744402 0.728326756110399 GNS 1 GO:0006517 protein deglycosylation 1/725 26/18722 0.642117236744402 0.728326756110399 MAN1A2 1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1/725 26/18722 0.642117236744402 0.728326756110399 SEC61B 1 GO:0006706 steroid catabolic process 1/725 26/18722 0.642117236744402 0.728326756110399 CYP19A1 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/725 26/18722 0.642117236744402 0.728326756110399 GABRE 1 GO:0019883 antigen processing and presentation of endogenous antigen 1/725 26/18722 0.642117236744402 0.728326756110399 B2M 1 GO:0032682 negative regulation of chemokine production 1/725 26/18722 0.642117236744402 0.728326756110399 ARG2 1 GO:0034114 regulation of heterotypic cell-cell adhesion 1/725 26/18722 0.642117236744402 0.728326756110399 BMP7 1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 1/725 26/18722 0.642117236744402 0.728326756110399 ARMCX3 1 GO:0042278 purine nucleoside metabolic process 1/725 26/18722 0.642117236744402 0.728326756110399 PNP 1 GO:0045026 plasma membrane fusion 1/725 26/18722 0.642117236744402 0.728326756110399 SPESP1 1 GO:0045672 positive regulation of osteoclast differentiation 1/725 26/18722 0.642117236744402 0.728326756110399 FOS 1 GO:0047497 mitochondrion transport along microtubule 1/725 26/18722 0.642117236744402 0.728326756110399 ARMCX3 1 GO:0050926 regulation of positive chemotaxis 1/725 26/18722 0.642117236744402 0.728326756110399 PGF 1 GO:0051560 mitochondrial calcium ion homeostasis 1/725 26/18722 0.642117236744402 0.728326756110399 AFG3L2 1 GO:0060295 regulation of cilium movement involved in cell motility 1/725 26/18722 0.642117236744402 0.728326756110399 CCSAP 1 GO:0070102 interleukin-6-mediated signaling pathway 1/725 26/18722 0.642117236744402 0.728326756110399 IL6ST 1 GO:0070977 bone maturation 1/725 26/18722 0.642117236744402 0.728326756110399 RHOA 1 GO:0071425 hematopoietic stem cell proliferation 1/725 26/18722 0.642117236744402 0.728326756110399 N4BP2L2 1 GO:0097186 amelogenesis 1/725 26/18722 0.642117236744402 0.728326756110399 CSF3R 1 GO:1902019 regulation of cilium-dependent cell motility 1/725 26/18722 0.642117236744402 0.728326756110399 CCSAP 1 GO:1902186 regulation of viral release from host cell 1/725 26/18722 0.642117236744402 0.728326756110399 DDB1 1 GO:1903523 negative regulation of blood circulation 1/725 26/18722 0.642117236744402 0.728326756110399 SRI 1 GO:0006650 glycerophospholipid metabolic process 11/725 306/18722 0.642388269660015 0.728471172014903 PRDX6/PISD/DBI/SOCS1/CHPT1/TMEM150A/GPCPD1/CDS1/HADHA/PIP4K2A/PIK3CB 11 GO:0032608 interferon-beta production 2/725 56/18722 0.643847712512006 0.729473414108931 RIPK2/HMGB1 2 GO:0032648 regulation of interferon-beta production 2/725 56/18722 0.643847712512006 0.729473414108931 RIPK2/HMGB1 2 GO:0043470 regulation of carbohydrate catabolic process 2/725 56/18722 0.643847712512006 0.729473414108931 APP/HMGB1 2 GO:0046456 icosanoid biosynthetic process 2/725 56/18722 0.643847712512006 0.729473414108931 MIF/ANXA1 2 GO:0055013 cardiac muscle cell development 3/725 85/18722 0.64460621361632 0.730006455947525 TBX3/ISL1/PLEC 3 GO:0097006 regulation of plasma lipoprotein particle levels 3/725 85/18722 0.64460621361632 0.730006455947525 LRPAP1/MYLIP/ARF1 3 GO:0019751 polyol metabolic process 4/725 114/18722 0.648683648226835 0.73445999840559 TPI1/PLPP3/AKR1B1/ISYNA1 4 GO:0008654 phospholipid biosynthetic process 9/725 253/18722 0.649493255550483 0.735212441354488 PISD/ISYNA1/IDH1/SOCS1/CHPT1/TMEM150A/CDS1/PIP4K2A/PIK3CB 9 GO:0002703 regulation of leukocyte mediated immunity 8/725 226/18722 0.651825388211896 0.736161251796381 SERPINB9/CD46/TFRC/HSPD1/DHX36/CD55/HMGB1/B2M 8 GO:0045921 positive regulation of exocytosis 3/725 86/18722 0.652438151871759 0.736161251796381 SYT7/ARF1/SDCBP 3 GO:0006611 protein export from nucleus 2/725 57/18722 0.653428065721205 0.736161251796381 PTPN14/MDM2 2 GO:0010883 regulation of lipid storage 2/725 57/18722 0.653428065721205 0.736161251796381 PLIN2/ITGAV 2 GO:0034205 amyloid-beta formation 2/725 57/18722 0.653428065721205 0.736161251796381 ROCK1/RTN4 2 GO:0051289 protein homotetramerization 2/725 57/18722 0.653428065721205 0.736161251796381 ALDOA/B2M 2 GO:0051785 positive regulation of nuclear division 2/725 57/18722 0.653428065721205 0.736161251796381 IGF2/LRP5 2 GO:0051048 negative regulation of secretion 6/725 171/18722 0.654001819008815 0.736161251796381 GJA1/ANXA1/PPP1R9A/RAB11FIP1/INHA/ERP29 6 GO:0000469 cleavage involved in rRNA processing 1/725 27/18722 0.655995339192001 0.736161251796381 RPS21 1 GO:0000737 DNA catabolic process, endonucleolytic 1/725 27/18722 0.655995339192001 0.736161251796381 DICER1 1 GO:0001835 blastocyst hatching 1/725 27/18722 0.655995339192001 0.736161251796381 UBE2A 1 GO:0003401 axis elongation 1/725 27/18722 0.655995339192001 0.736161251796381 RDH10 1 GO:0007263 nitric oxide mediated signal transduction 1/725 27/18722 0.655995339192001 0.736161251796381 EGFR 1 GO:0010758 regulation of macrophage chemotaxis 1/725 27/18722 0.655995339192001 0.736161251796381 MIF 1 GO:0018904 ether metabolic process 1/725 27/18722 0.655995339192001 0.736161251796381 CHPT1 1 GO:0032703 negative regulation of interleukin-2 production 1/725 27/18722 0.655995339192001 0.736161251796381 EZR 1 GO:0032781 positive regulation of ATPase activity 1/725 27/18722 0.655995339192001 0.736161251796381 PFN1 1 GO:0032786 positive regulation of DNA-templated transcription, elongation 1/725 27/18722 0.655995339192001 0.736161251796381 BRD4 1 GO:0034143 regulation of toll-like receptor 4 signaling pathway 1/725 27/18722 0.655995339192001 0.736161251796381 HMGB1 1 GO:0034377 plasma lipoprotein particle assembly 1/725 27/18722 0.655995339192001 0.736161251796381 ARF1 1 GO:0034505 tooth mineralization 1/725 27/18722 0.655995339192001 0.736161251796381 TFAP2A 1 GO:0035188 hatching 1/725 27/18722 0.655995339192001 0.736161251796381 UBE2A 1 GO:0035459 vesicle cargo loading 1/725 27/18722 0.655995339192001 0.736161251796381 RAB1A 1 GO:0039529 RIG-I signaling pathway 1/725 27/18722 0.655995339192001 0.736161251796381 PUM1 1 GO:0042402 cellular biogenic amine catabolic process 1/725 27/18722 0.655995339192001 0.736161251796381 MAOA 1 GO:0042745 circadian sleep/wake cycle 1/725 27/18722 0.655995339192001 0.736161251796381 ADRB1 1 GO:0045830 positive regulation of isotype switching 1/725 27/18722 0.655995339192001 0.736161251796381 TFRC 1 GO:0046174 polyol catabolic process 1/725 27/18722 0.655995339192001 0.736161251796381 TPI1 1 GO:0046337 phosphatidylethanolamine metabolic process 1/725 27/18722 0.655995339192001 0.736161251796381 PISD 1 GO:0048520 positive regulation of behavior 1/725 27/18722 0.655995339192001 0.736161251796381 GJA1 1 GO:0048873 homeostasis of number of cells within a tissue 1/725 27/18722 0.655995339192001 0.736161251796381 BCL2 1 GO:0051953 negative regulation of amine transport 1/725 27/18722 0.655995339192001 0.736161251796381 ARL6IP5 1 GO:0060333 interferon-gamma-mediated signaling pathway 1/725 27/18722 0.655995339192001 0.736161251796381 SOCS1 1 GO:0060512 prostate gland morphogenesis 1/725 27/18722 0.655995339192001 0.736161251796381 BMP7 1 GO:0071624 positive regulation of granulocyte chemotaxis 1/725 27/18722 0.655995339192001 0.736161251796381 RAC1 1 GO:0071684 organism emergence from protective structure 1/725 27/18722 0.655995339192001 0.736161251796381 UBE2A 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/725 27/18722 0.655995339192001 0.736161251796381 AKAP9 1 GO:1903203 regulation of oxidative stress-induced neuron death 1/725 27/18722 0.655995339192001 0.736161251796381 PARP1 1 GO:1903859 regulation of dendrite extension 1/725 27/18722 0.655995339192001 0.736161251796381 SPAG9 1 GO:0048515 spermatid differentiation 6/725 172/18722 0.659529121091795 0.739672775577643 DYNLL1/NEURL1/JAM3/QKI/CDYL/AFF4 6 GO:0014065 phosphatidylinositol 3-kinase signaling 5/725 144/18722 0.659927560242237 0.739672775577643 EGFR/NF1/CAT/FLT1/PIK3CB 5 GO:0046486 glycerolipid metabolic process 14/725 392/18722 0.659962710241129 0.739672775577643 PRDX6/CAV1/PISD/DBI/LPIN2/SOCS1/CHPT1/TMEM150A/GPCPD1/CAT/CDS1/HADHA/PIP4K2A/PIK3CB 14 GO:0007029 endoplasmic reticulum organization 3/725 87/18722 0.660145913733134 0.739672775577643 LMAN1/CCDC47/RTN4 3 GO:0019646 aerobic electron transport chain 3/725 87/18722 0.660145913733134 0.739672775577643 COX6A1/UQCRH/SDHA 3 GO:0051262 protein tetramerization 3/725 87/18722 0.660145913733134 0.739672775577643 ALDOA/HOMER1/B2M 3 GO:1901606 alpha-amino acid catabolic process 3/725 87/18722 0.660145913733134 0.739672775577643 GLDC/GLUL/ARG2 3 GO:0002763 positive regulation of myeloid leukocyte differentiation 2/725 58/18722 0.662801769124184 0.74182869677423 FOS/JUN 2 GO:0007405 neuroblast proliferation 2/725 58/18722 0.662801769124184 0.74182869677423 GLI3/NF1 2 GO:0010574 regulation of vascular endothelial growth factor production 2/725 58/18722 0.662801769124184 0.74182869677423 ISL1/IL6ST 2 GO:0050432 catecholamine secretion 2/725 58/18722 0.662801769124184 0.74182869677423 SYT7/LY6E 2 GO:0097035 regulation of membrane lipid distribution 2/725 58/18722 0.662801769124184 0.74182869677423 KCNN4/ABCB1 2 GO:1901657 glycosyl compound metabolic process 3/725 88/18722 0.667729376240677 0.744865885732587 AKR1B1/UPP1/PNP 3 GO:0072676 lymphocyte migration 4/725 117/18722 0.668713556544409 0.744865885732587 APP/RHOA/PLEC/CD99 4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1/725 28/18722 0.669335985305175 0.744865885732587 B2M 1 GO:0002675 positive regulation of acute inflammatory response 1/725 28/18722 0.669335985305175 0.744865885732587 IL6ST 1 GO:0003156 regulation of animal organ formation 1/725 28/18722 0.669335985305175 0.744865885732587 BMP7 1 GO:0006829 zinc ion transport 1/725 28/18722 0.669335985305175 0.744865885732587 SLC39A10 1 GO:0007141 male meiosis I 1/725 28/18722 0.669335985305175 0.744865885732587 SLC2A8 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/725 28/18722 0.669335985305175 0.744865885732587 LRP1 1 GO:0008299 isoprenoid biosynthetic process 1/725 28/18722 0.669335985305175 0.744865885732587 RDH10 1 GO:0009312 oligosaccharide biosynthetic process 1/725 28/18722 0.669335985305175 0.744865885732587 FUT8 1 GO:0010460 positive regulation of heart rate 1/725 28/18722 0.669335985305175 0.744865885732587 ADRB1 1 GO:0010464 regulation of mesenchymal cell proliferation 1/725 28/18722 0.669335985305175 0.744865885732587 LRP5 1 GO:0010818 T cell chemotaxis 1/725 28/18722 0.669335985305175 0.744865885732587 PLEC 1 GO:0010884 positive regulation of lipid storage 1/725 28/18722 0.669335985305175 0.744865885732587 PLIN2 1 GO:0030262 apoptotic nuclear changes 1/725 28/18722 0.669335985305175 0.744865885732587 DICER1 1 GO:0031342 negative regulation of cell killing 1/725 28/18722 0.669335985305175 0.744865885732587 SERPINB9 1 GO:0031440 regulation of mRNA 3'-end processing 1/725 28/18722 0.669335985305175 0.744865885732587 DHX36 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/725 28/18722 0.669335985305175 0.744865885732587 CTNND1 1 GO:0051503 adenine nucleotide transport 1/725 28/18722 0.669335985305175 0.744865885732587 GJA1 1 GO:0060765 regulation of androgen receptor signaling pathway 1/725 28/18722 0.669335985305175 0.744865885732587 DDX5 1 GO:0061082 myeloid leukocyte cytokine production 1/725 28/18722 0.669335985305175 0.744865885732587 DHX36 1 GO:0062125 regulation of mitochondrial gene expression 1/725 28/18722 0.669335985305175 0.744865885732587 CHCHD10 1 GO:0086011 membrane repolarization during action potential 1/725 28/18722 0.669335985305175 0.744865885732587 CAV1 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/725 28/18722 0.669335985305175 0.744865885732587 PMAIP1 1 GO:1903020 positive regulation of glycoprotein metabolic process 1/725 28/18722 0.669335985305175 0.744865885732587 RAB1A 1 GO:1903649 regulation of cytoplasmic transport 1/725 28/18722 0.669335985305175 0.744865885732587 EZR 1 GO:0002820 negative regulation of adaptive immune response 2/725 59/18722 0.671970437523866 0.747469420190581 CD46/CD55 2 GO:0019369 arachidonic acid metabolic process 2/725 59/18722 0.671970437523866 0.747469420190581 CYP2J2/GPX4 2 GO:0009308 amine metabolic process 4/725 118/18722 0.675213321937185 0.750911875581305 AKR1B1/OAZ1/MAOA/LY6E 4 GO:0046394 carboxylic acid biosynthetic process 11/725 314/18722 0.675489308398699 0.751054025942752 MIF/ACSS1/HACD3/ANXA1/SLC27A2/SCD/GLUL/MTR/RDH10/GPX4/QKI 11 GO:0006289 nucleotide-excision repair 2/725 60/18722 0.680935870470049 0.75499319754441 DDB1/HMGB1 2 GO:0009620 response to fungus 2/725 60/18722 0.680935870470049 0.75499319754441 GAPDH/S100A9 2 GO:0042306 regulation of protein import into nucleus 2/725 60/18722 0.680935870470049 0.75499319754441 CDH1/GLI3 2 GO:0001916 positive regulation of T cell mediated cytotoxicity 1/725 29/18722 0.682159961482224 0.75499319754441 B2M 1 GO:0005979 regulation of glycogen biosynthetic process 1/725 29/18722 0.682159961482224 0.75499319754441 IGF2 1 GO:0006734 NADH metabolic process 1/725 29/18722 0.682159961482224 0.75499319754441 ENO1 1 GO:0009310 amine catabolic process 1/725 29/18722 0.682159961482224 0.75499319754441 MAOA 1 GO:0010458 exit from mitosis 1/725 29/18722 0.682159961482224 0.75499319754441 RPL24 1 GO:0010962 regulation of glucan biosynthetic process 1/725 29/18722 0.682159961482224 0.75499319754441 IGF2 1 GO:0015701 bicarbonate transport 1/725 29/18722 0.682159961482224 0.75499319754441 SLC26A2 1 GO:0015868 purine ribonucleotide transport 1/725 29/18722 0.682159961482224 0.75499319754441 GJA1 1 GO:0019082 viral protein processing 1/725 29/18722 0.682159961482224 0.75499319754441 FUT8 1 GO:0031069 hair follicle morphogenesis 1/725 29/18722 0.682159961482224 0.75499319754441 BCL2 1 GO:0034311 diol metabolic process 1/725 29/18722 0.682159961482224 0.75499319754441 PLPP3 1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1/725 29/18722 0.682159961482224 0.75499319754441 EGFR 1 GO:0048753 pigment granule organization 1/725 29/18722 0.682159961482224 0.75499319754441 BCL2 1 GO:0051654 establishment of mitochondrion localization 1/725 29/18722 0.682159961482224 0.75499319754441 ARMCX3 1 GO:0051873 killing by host of symbiont cells 1/725 29/18722 0.682159961482224 0.75499319754441 GAPDH 1 GO:0051883 killing of cells in other organism involved in symbiotic interaction 1/725 29/18722 0.682159961482224 0.75499319754441 GAPDH 1 GO:0070198 protein localization to chromosome, telomeric region 1/725 29/18722 0.682159961482224 0.75499319754441 ATRX 1 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 1/725 29/18722 0.682159961482224 0.75499319754441 CAV1 1 GO:0045638 negative regulation of myeloid cell differentiation 3/725 90/18722 0.682523490108386 0.75523064207802 FBN1/FSTL3/INHA 3 GO:0016053 organic acid biosynthetic process 11/725 316/18722 0.683479932057766 0.75612391436072 MIF/ACSS1/HACD3/ANXA1/SLC27A2/SCD/GLUL/MTR/RDH10/GPX4/QKI 11 GO:2000401 regulation of lymphocyte migration 2/725 61/18722 0.68970003557061 0.762543939562714 APP/RHOA 2 GO:0002275 myeloid cell activation involved in immune response 3/725 91/18722 0.689734457071423 0.762543939562714 GRN/VAMP2/HMGB1 3 GO:0051952 regulation of amine transport 3/725 91/18722 0.689734457071423 0.762543939562714 ITGB1/ARL6IP5/SYT7 3 GO:0043244 regulation of protein-containing complex disassembly 4/725 121/18722 0.694178481920279 0.765791341159161 TRIOBP/UVRAG/EIF5A/CAPZB 4 GO:0006221 pyrimidine nucleotide biosynthetic process 1/725 30/18722 0.694487251265854 0.765791341159161 UPP1 1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/725 30/18722 0.694487251265854 0.765791341159161 DICER1 1 GO:0010453 regulation of cell fate commitment 1/725 30/18722 0.694487251265854 0.765791341159161 HES1 1 GO:0015865 purine nucleotide transport 1/725 30/18722 0.694487251265854 0.765791341159161 GJA1 1 GO:0017145 stem cell division 1/725 30/18722 0.694487251265854 0.765791341159161 NCOA3 1 GO:0033137 negative regulation of peptidyl-serine phosphorylation 1/725 30/18722 0.694487251265854 0.765791341159161 CAV1 1 GO:0034694 response to prostaglandin 1/725 30/18722 0.694487251265854 0.765791341159161 TGFBR3 1 GO:0036258 multivesicular body assembly 1/725 30/18722 0.694487251265854 0.765791341159161 RAB11A 1 GO:0045577 regulation of B cell differentiation 1/725 30/18722 0.694487251265854 0.765791341159161 INHA 1 GO:0048799 animal organ maturation 1/725 30/18722 0.694487251265854 0.765791341159161 RHOA 1 GO:0070168 negative regulation of biomineral tissue development 1/725 30/18722 0.694487251265854 0.765791341159161 ROCK1 1 GO:0001959 regulation of cytokine-mediated signaling pathway 5/725 150/18722 0.69463574406191 0.765791341159161 CAV1/SOCS1/TRIM44/HSPA1A/RIPK2 5 GO:0007626 locomotory behavior 6/725 179/18722 0.696655649077745 0.767366809514105 APP/GAA/ARRDC3/ZFHX3/PUM1/NCOA2 6 GO:0006497 protein lipidation 3/725 92/18722 0.696821744760983 0.767366809514105 DBI/GLUL/NMT1 3 GO:0034502 protein localization to chromosome 3/725 92/18722 0.696821744760983 0.767366809514105 ATRX/NIPBL/SETD2 3 GO:0035249 synaptic transmission, glutamatergic 3/725 92/18722 0.696821744760983 0.767366809514105 EGFR/GLUL/HOMER1 3 GO:0048525 negative regulation of viral process 3/725 92/18722 0.696821744760983 0.767366809514105 MPHOSPH8/LY6E/PPIA 3 GO:0002253 activation of immune response 13/725 375/18722 0.697723702258594 0.767955207793432 CD46/SLC39A10/PRKDC/KCNN4/EZR/PDE4B/BCL2/CD55/HRAS/RIPK2/HMGB1/PHPT1/CBLB 13 GO:0009116 nucleoside metabolic process 2/725 62/18722 0.698265052815136 0.767955207793432 UPP1/PNP 2 GO:0031124 mRNA 3'-end processing 2/725 62/18722 0.698265052815136 0.767955207793432 APP/DHX36 2 GO:0046148 pigment biosynthetic process 2/725 62/18722 0.698265052815136 0.767955207793432 OPN3/MFSD12 2 GO:0046173 polyol biosynthetic process 2/725 62/18722 0.698265052815136 0.767955207793432 AKR1B1/ISYNA1 2 GO:0070265 necrotic cell death 2/725 62/18722 0.698265052815136 0.767955207793432 CAV1/CFLAR 2 GO:0016042 lipid catabolic process 11/725 320/18722 0.699107165182417 0.768714581412076 PRDX6/LRP1/SLC27A2/CROT/IDH1/LPIN2/HEXA/GPCPD1/HADHA/ECHDC2/CYP19A1 11 GO:0055067 monovalent inorganic cation homeostasis 5/725 151/18722 0.700177549376876 0.769724571197438 ATP6V0E1/GRN/BCL2/SLC9A1/ATP6AP2 5 GO:0050871 positive regulation of B cell activation 5/725 152/18722 0.705649449192988 0.772808674537607 MIF/TFRC/SLC39A10/BCL2/CDKN1A 5 GO:0001782 B cell homeostasis 1/725 31/18722 0.706337066311448 0.772808674537607 BCL2 1 GO:0002063 chondrocyte development 1/725 31/18722 0.706337066311448 0.772808674537607 SERPINH1 1 GO:0002230 positive regulation of defense response to virus by host 1/725 31/18722 0.706337066311448 0.772808674537607 TRIM44 1 GO:0018200 peptidyl-glutamic acid modification 1/725 31/18722 0.706337066311448 0.772808674537607 PARP1 1 GO:0030149 sphingolipid catabolic process 1/725 31/18722 0.706337066311448 0.772808674537607 HEXA 1 GO:0032148 activation of protein kinase B activity 1/725 31/18722 0.706337066311448 0.772808674537607 PPIA 1 GO:0032509 endosome transport via multivesicular body sorting pathway 1/725 31/18722 0.706337066311448 0.772808674537607 LEPROTL1 1 GO:0036257 multivesicular body organization 1/725 31/18722 0.706337066311448 0.772808674537607 RAB11A 1 GO:0043171 peptide catabolic process 1/725 31/18722 0.706337066311448 0.772808674537607 ENPEP 1 GO:0045987 positive regulation of smooth muscle contraction 1/725 31/18722 0.706337066311448 0.772808674537607 RHOA 1 GO:0048384 retinoic acid receptor signaling pathway 1/725 31/18722 0.706337066311448 0.772808674537607 ESRRG 1 GO:0050482 arachidonic acid secretion 1/725 31/18722 0.706337066311448 0.772808674537607 ANXA1 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/725 31/18722 0.706337066311448 0.772808674537607 GJA1 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/725 31/18722 0.706337066311448 0.772808674537607 RTF1 1 GO:0061117 negative regulation of heart growth 1/725 31/18722 0.706337066311448 0.772808674537607 GJA1 1 GO:0065005 protein-lipid complex assembly 1/725 31/18722 0.706337066311448 0.772808674537607 ARF1 1 GO:0070528 protein kinase C signaling 1/725 31/18722 0.706337066311448 0.772808674537607 ADGRG1 1 GO:0070723 response to cholesterol 1/725 31/18722 0.706337066311448 0.772808674537607 DAG1 1 GO:0097106 postsynaptic density organization 1/725 31/18722 0.706337066311448 0.772808674537607 DLG1 1 GO:0110150 negative regulation of biomineralization 1/725 31/18722 0.706337066311448 0.772808674537607 ROCK1 1 GO:1903963 arachidonate transport 1/725 31/18722 0.706337066311448 0.772808674537607 ANXA1 1 GO:0007368 determination of left/right symmetry 4/725 124/18722 0.712340578455487 0.77920897544041 GALNT11/TBX3/MIB1/ENG 4 GO:0046474 glycerophospholipid biosynthetic process 7/725 211/18722 0.713493898421978 0.780302172837326 PISD/SOCS1/CHPT1/TMEM150A/CDS1/PIP4K2A/PIK3CB 7 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 2/725 64/18722 0.714806798208581 0.781569383114603 EIF3H/SDCBP 2 GO:0003180 aortic valve morphogenesis 1/725 32/18722 0.717727876162403 0.782568854434765 ROCK1 1 GO:0006026 aminoglycan catabolic process 1/725 32/18722 0.717727876162403 0.782568854434765 GNS 1 GO:0006308 DNA catabolic process 1/725 32/18722 0.717727876162403 0.782568854434765 DICER1 1 GO:0006335 DNA replication-dependent nucleosome assembly 1/725 32/18722 0.717727876162403 0.782568854434765 NASP 1 GO:0008156 negative regulation of DNA replication 1/725 32/18722 0.717727876162403 0.782568854434765 S100A11 1 GO:0010743 regulation of macrophage derived foam cell differentiation 1/725 32/18722 0.717727876162403 0.782568854434765 ITGAV 1 GO:0032196 transposition 1/725 32/18722 0.717727876162403 0.782568854434765 L1TD1 1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 1/725 32/18722 0.717727876162403 0.782568854434765 BRD4 1 GO:0034723 DNA replication-dependent nucleosome organization 1/725 32/18722 0.717727876162403 0.782568854434765 NASP 1 GO:0035883 enteroendocrine cell differentiation 1/725 32/18722 0.717727876162403 0.782568854434765 HES1 1 GO:0050850 positive regulation of calcium-mediated signaling 1/725 32/18722 0.717727876162403 0.782568854434765 SLC9A1 1 GO:0061036 positive regulation of cartilage development 1/725 32/18722 0.717727876162403 0.782568854434765 GLI3 1 GO:0061037 negative regulation of cartilage development 1/725 32/18722 0.717727876162403 0.782568854434765 EFEMP1 1 GO:0006487 protein N-linked glycosylation 2/725 65/18722 0.722788400285574 0.787578332125446 RPN2/FUT8 2 GO:0046503 glycerolipid catabolic process 2/725 65/18722 0.722788400285574 0.787578332125446 PRDX6/GPCPD1 2 GO:0046513 ceramide biosynthetic process 2/725 65/18722 0.722788400285574 0.787578332125446 ORMDL1/SPTSSA 2 GO:0015914 phospholipid transport 3/725 96/18722 0.723943518970085 0.787990057474632 KCNN4/ABCB1/DBI 3 GO:0042158 lipoprotein biosynthetic process 3/725 96/18722 0.723943518970085 0.787990057474632 DBI/GLUL/NMT1 3 GO:0042632 cholesterol homeostasis 3/725 96/18722 0.723943518970085 0.787990057474632 CAV1/LRP5/MYLIP 3 GO:0043648 dicarboxylic acid metabolic process 3/725 96/18722 0.723943518970085 0.787990057474632 IDH1/GLUL/SDHA 3 GO:0055017 cardiac muscle tissue growth 3/725 96/18722 0.723943518970085 0.787990057474632 TGFBR3/GJA1/RBPJ 3 GO:0006536 glutamate metabolic process 1/725 33/18722 0.728677436878415 0.790596302983024 GLUL 1 GO:0006891 intra-Golgi vesicle-mediated transport 1/725 33/18722 0.728677436878415 0.790596302983024 CUX1 1 GO:0018345 protein palmitoylation 1/725 33/18722 0.728677436878415 0.790596302983024 GLUL 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 1/725 33/18722 0.728677436878415 0.790596302983024 PDCD6 1 GO:0032228 regulation of synaptic transmission, GABAergic 1/725 33/18722 0.728677436878415 0.790596302983024 KIF5B 1 GO:0042558 pteridine-containing compound metabolic process 1/725 33/18722 0.728677436878415 0.790596302983024 MTR 1 GO:0045920 negative regulation of exocytosis 1/725 33/18722 0.728677436878415 0.790596302983024 ANXA1 1 GO:0048730 epidermis morphogenesis 1/725 33/18722 0.728677436878415 0.790596302983024 BCL2 1 GO:0071763 nuclear membrane organization 1/725 33/18722 0.728677436878415 0.790596302983024 NEK6 1 GO:0099084 postsynaptic specialization organization 1/725 33/18722 0.728677436878415 0.790596302983024 DLG1 1 GO:0099174 regulation of presynapse organization 1/725 33/18722 0.728677436878415 0.790596302983024 APP 1 GO:1901380 negative regulation of potassium ion transmembrane transport 1/725 33/18722 0.728677436878415 0.790596302983024 CAV1 1 GO:1903146 regulation of autophagy of mitochondrion 1/725 33/18722 0.728677436878415 0.790596302983024 BNIP3L 1 GO:1903715 regulation of aerobic respiration 1/725 33/18722 0.728677436878415 0.790596302983024 RHOA 1 GO:1905606 regulation of presynapse assembly 1/725 33/18722 0.728677436878415 0.790596302983024 APP 1 GO:0055092 sterol homeostasis 3/725 97/18722 0.730420203633888 0.791983093720695 CAV1/LRP5/MYLIP 3 GO:0050766 positive regulation of phagocytosis 2/725 66/18722 0.730580577281114 0.791983093720695 LRP1/CYBA 2 GO:0071300 cellular response to retinoic acid 2/725 66/18722 0.730580577281114 0.791983093720695 SLC6A4/SERPINF1 2 GO:1902476 chloride transmembrane transport 2/725 66/18722 0.730580577281114 0.791983093720695 SLC26A2/GABRE 2 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 9/725 273/18722 0.734677760068762 0.796254343764925 ITGB1/TENM3/CDH1/DSC3/DSG2/CLDN4/PCDH11X/DSC2/PTPRF 9 GO:0032890 regulation of organic acid transport 2/725 67/18722 0.738186007799675 0.798427250646704 ITGB1/ARL6IP5 2 GO:0048814 regulation of dendrite morphogenesis 2/725 67/18722 0.738186007799675 0.798427250646704 CUX1/DHX36 2 GO:0050435 amyloid-beta metabolic process 2/725 67/18722 0.738186007799675 0.798427250646704 ROCK1/RTN4 2 GO:0072665 protein localization to vacuole 2/725 67/18722 0.738186007799675 0.798427250646704 HSPA8/RTN4 2 GO:0000096 sulfur amino acid metabolic process 1/725 34/18722 0.739202818560857 0.798427250646704 MTR 1 GO:0006270 DNA replication initiation 1/725 34/18722 0.739202818560857 0.798427250646704 PURA 1 GO:0007095 mitotic G2 DNA damage checkpoint signaling 1/725 34/18722 0.739202818560857 0.798427250646704 CDKN1A 1 GO:0007616 long-term memory 1/725 34/18722 0.739202818560857 0.798427250646704 SGK1 1 GO:0010661 positive regulation of muscle cell apoptotic process 1/725 34/18722 0.739202818560857 0.798427250646704 PDCD4 1 GO:0034383 low-density lipoprotein particle clearance 1/725 34/18722 0.739202818560857 0.798427250646704 MYLIP 1 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1/725 34/18722 0.739202818560857 0.798427250646704 PUM1 1 GO:0042573 retinoic acid metabolic process 1/725 34/18722 0.739202818560857 0.798427250646704 RDH10 1 GO:0050869 negative regulation of B cell activation 1/725 34/18722 0.739202818560857 0.798427250646704 INHA 1 GO:0055094 response to lipoprotein particle 1/725 34/18722 0.739202818560857 0.798427250646704 ITGB1 1 GO:0070050 neuron cellular homeostasis 1/725 34/18722 0.739202818560857 0.798427250646704 ATP2B1 1 GO:0070232 regulation of T cell apoptotic process 1/725 34/18722 0.739202818560857 0.798427250646704 ARG2 1 GO:0046488 phosphatidylinositol metabolic process 5/725 159/18722 0.741992020400671 0.801269184365361 SOCS1/TMEM150A/CDS1/PIP4K2A/PIK3CB 5 GO:0002366 leukocyte activation involved in immune response 9/725 275/18722 0.742372059569782 0.801348969042501 CD46/TFRC/HSPD1/RPS6/ANXA1/GRN/VAMP2/RIPK2/HMGB1 9 GO:0002444 myeloid leukocyte mediated immunity 3/725 99/18722 0.743014431741913 0.801348969042501 SERPINB9/DHX36/VAMP2 3 GO:0007631 feeding behavior 3/725 99/18722 0.743014431741913 0.801348969042501 FOS/APP/GDF15 3 GO:0015837 amine transport 3/725 99/18722 0.743014431741913 0.801348969042501 ITGB1/ARL6IP5/SYT7 3 GO:0021549 cerebellum development 3/725 99/18722 0.743014431741913 0.801348969042501 HSPA5/RERE/SEMA4C 3 GO:0031341 regulation of cell killing 3/725 99/18722 0.743014431741913 0.801348969042501 SERPINB9/CD55/B2M 3 GO:1901607 alpha-amino acid biosynthetic process 2/725 68/18722 0.745607447225243 0.803974505421135 GLUL/MTR 2 GO:0006641 triglyceride metabolic process 3/725 100/18722 0.749133776956264 0.80557906020865 CAV1/LPIN2/CAT 3 GO:0051588 regulation of neurotransmitter transport 3/725 100/18722 0.749133776956264 0.80557906020865 ITGB1/CALM1/PPP1R9A 3 GO:0000731 DNA synthesis involved in DNA repair 1/725 35/18722 0.749320431817673 0.80557906020865 USP10 1 GO:0001569 branching involved in blood vessel morphogenesis 1/725 35/18722 0.749320431817673 0.80557906020865 ENG 1 GO:0008608 attachment of spindle microtubules to kinetochore 1/725 35/18722 0.749320431817673 0.80557906020865 CDC42 1 GO:0010837 regulation of keratinocyte proliferation 1/725 35/18722 0.749320431817673 0.80557906020865 SRSF6 1 GO:0019068 virion assembly 1/725 35/18722 0.749320431817673 0.80557906020865 RAB1A 1 GO:0032350 regulation of hormone metabolic process 1/725 35/18722 0.749320431817673 0.80557906020865 RDH10 1 GO:0042462 eye photoreceptor cell development 1/725 35/18722 0.749320431817673 0.80557906020865 RDH13 1 GO:0044273 sulfur compound catabolic process 1/725 35/18722 0.749320431817673 0.80557906020865 GNS 1 GO:0046471 phosphatidylglycerol metabolic process 1/725 35/18722 0.749320431817673 0.80557906020865 HADHA 1 GO:0070536 protein K63-linked deubiquitination 1/725 35/18722 0.749320431817673 0.80557906020865 USP27X 1 GO:0072528 pyrimidine-containing compound biosynthetic process 1/725 35/18722 0.749320431817673 0.80557906020865 UPP1 1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1/725 35/18722 0.749320431817673 0.80557906020865 ANXA1 1 GO:0042113 B cell activation 11/725 334/18722 0.749958023631824 0.806093558479583 ITGB1/MIF/TFRC/SLC39A10/HSPD1/PRKDC/RBPJ/TPD52/BCL2/INHA/CDKN1A 11 GO:0019226 transmission of nerve impulse 2/725 69/18722 0.752847717779124 0.808685120030171 JAM3/PLEC 2 GO:0033344 cholesterol efflux 2/725 69/18722 0.752847717779124 0.808685120030171 CAV1/LRP1 2 GO:0070192 chromosome organization involved in meiotic cell cycle 2/725 69/18722 0.752847717779124 0.808685120030171 ATRX/RAD50 2 GO:0051963 regulation of synapse assembly 3/725 101/18722 0.755135909574086 0.810971170684543 DLG5/APP/PPP1R9A 3 GO:0060759 regulation of response to cytokine stimulus 5/725 162/18722 0.756520703858486 0.812073542362679 CAV1/SOCS1/TRIM44/HSPA1A/RIPK2 5 GO:0003352 regulation of cilium movement 1/725 36/18722 0.759046053208596 0.812073542362679 CCSAP 1 GO:0006699 bile acid biosynthetic process 1/725 36/18722 0.759046053208596 0.812073542362679 SLC27A2 1 GO:0014046 dopamine secretion 1/725 36/18722 0.759046053208596 0.812073542362679 SYT7 1 GO:0014059 regulation of dopamine secretion 1/725 36/18722 0.759046053208596 0.812073542362679 SYT7 1 GO:0017004 cytochrome complex assembly 1/725 36/18722 0.759046053208596 0.812073542362679 CYBA 1 GO:0030224 monocyte differentiation 1/725 36/18722 0.759046053208596 0.812073542362679 JUN 1 GO:0036314 response to sterol 1/725 36/18722 0.759046053208596 0.812073542362679 DAG1 1 GO:0042119 neutrophil activation 1/725 36/18722 0.759046053208596 0.812073542362679 GRN 1 GO:0042755 eating behavior 1/725 36/18722 0.759046053208596 0.812073542362679 GDF15 1 GO:0044743 protein transmembrane import into intracellular organelle 1/725 36/18722 0.759046053208596 0.812073542362679 HSPD1 1 GO:0045191 regulation of isotype switching 1/725 36/18722 0.759046053208596 0.812073542362679 TFRC 1 GO:0045652 regulation of megakaryocyte differentiation 1/725 36/18722 0.759046053208596 0.812073542362679 RCOR1 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 1/725 36/18722 0.759046053208596 0.812073542362679 NEURL1 1 GO:0046466 membrane lipid catabolic process 1/725 36/18722 0.759046053208596 0.812073542362679 HEXA 1 GO:0051354 negative regulation of oxidoreductase activity 1/725 36/18722 0.759046053208596 0.812073542362679 CAV1 1 GO:0070306 lens fiber cell differentiation 1/725 36/18722 0.759046053208596 0.812073542362679 KDM5B 1 GO:0071402 cellular response to lipoprotein particle stimulus 1/725 36/18722 0.759046053208596 0.812073542362679 ITGB1 1 GO:0045017 glycerolipid biosynthetic process 8/725 252/18722 0.764300686769942 0.817522722354259 PISD/LPIN2/SOCS1/CHPT1/TMEM150A/CDS1/PIP4K2A/PIK3CB 8 GO:0008344 adult locomotory behavior 2/725 71/18722 0.766796320225807 0.819826035188296 APP/PUM1 2 GO:0000154 rRNA modification 1/725 37/18722 0.768394849709922 0.819826035188296 NOP10 1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1/725 37/18722 0.768394849709922 0.819826035188296 UPF2 1 GO:0006623 protein targeting to vacuole 1/725 37/18722 0.768394849709922 0.819826035188296 HSPA8 1 GO:0006904 vesicle docking involved in exocytosis 1/725 37/18722 0.768394849709922 0.819826035188296 RALB 1 GO:0007340 acrosome reaction 1/725 37/18722 0.768394849709922 0.819826035188296 SPESP1 1 GO:0033260 nuclear DNA replication 1/725 37/18722 0.768394849709922 0.819826035188296 ATRX 1 GO:0042401 cellular biogenic amine biosynthetic process 1/725 37/18722 0.768394849709922 0.819826035188296 OAZ1 1 GO:0043687 post-translational protein modification 1/725 37/18722 0.768394849709922 0.819826035188296 UCHL3 1 GO:0051954 positive regulation of amine transport 1/725 37/18722 0.768394849709922 0.819826035188296 ITGB1 1 GO:0097484 dendrite extension 1/725 37/18722 0.768394849709922 0.819826035188296 SPAG9 1 GO:1900016 negative regulation of cytokine production involved in inflammatory response 1/725 37/18722 0.768394849709922 0.819826035188296 PDCD4 1 GO:0009581 detection of external stimulus 4/725 135/18722 0.772134720242437 0.823632219418175 OPN3/NMT1/GNAQ/CDS1 4 GO:0022600 digestive system process 3/725 104/18722 0.772449708248965 0.823632219418175 KCNN4/EZR/SGK1 3 GO:0032006 regulation of TOR signaling 3/725 104/18722 0.772449708248965 0.823632219418175 GNA12/PDCD6/SLC38A9 3 GO:1901880 negative regulation of protein depolymerization 2/725 72/18722 0.773510550198294 0.824589900936941 TRIOBP/CAPZB 2 GO:0043547 positive regulation of GTPase activity 8/725 255/18722 0.775418193646284 0.826449710595671 SYDE1/ITGB1/ITGA6/ADRB1/NF1/NET1/HRAS/RASA1 8 GO:0099024 plasma membrane invagination 4/725 136/18722 0.777051886895316 0.82715078252249 RHOA/CDC42/RAC1/ARF1 4 GO:0009309 amine biosynthetic process 1/725 38/18722 0.777381402236564 0.82715078252249 OAZ1 1 GO:0010742 macrophage derived foam cell differentiation 1/725 38/18722 0.777381402236564 0.82715078252249 ITGAV 1 GO:0046329 negative regulation of JNK cascade 1/725 38/18722 0.777381402236564 0.82715078252249 PDCD4 1 GO:0048246 macrophage chemotaxis 1/725 38/18722 0.777381402236564 0.82715078252249 MIF 1 GO:0051930 regulation of sensory perception of pain 1/725 38/18722 0.777381402236564 0.82715078252249 SLC9A1 1 GO:0072524 pyridine-containing compound metabolic process 1/725 38/18722 0.777381402236564 0.82715078252249 PNP 1 GO:0090077 foam cell differentiation 1/725 38/18722 0.777381402236564 0.82715078252249 ITGAV 1 GO:0016079 synaptic vesicle exocytosis 3/725 105/18722 0.777993901791893 0.82762876981807 CALM1/SYT7/VAMP2 3 GO:0055088 lipid homeostasis 5/725 167/18722 0.779358971171421 0.828906971227011 CAV1/ORMDL1/LRP5/MYLIP/RTN4 5 GO:0002637 regulation of immunoglobulin production 2/725 73/18722 0.780055391833765 0.828951945745357 TFRC/PRKDC 2 GO:0032456 endocytic recycling 2/725 73/18722 0.780055391833765 0.828951945745357 SNX27/RAB11A 2 GO:0051298 centrosome duplication 2/725 73/18722 0.780055391833765 0.828951945745357 CEP152/NPM1 2 GO:0051937 catecholamine transport 2/725 73/18722 0.780055391833765 0.828951945745357 SYT7/LY6E 2 GO:0060078 regulation of postsynaptic membrane potential 4/725 137/18722 0.781884914579062 0.830721993712275 APP/ADRB1/GABRE/PPP1R9A 4 GO:0050864 regulation of B cell activation 6/725 198/18722 0.783254240334374 0.832002461076057 MIF/TFRC/SLC39A10/BCL2/INHA/CDKN1A 6 GO:0001914 regulation of T cell mediated cytotoxicity 1/725 39/18722 0.786019728257677 0.833368333515617 B2M 1 GO:0002701 negative regulation of production of molecular mediator of immune response 1/725 39/18722 0.786019728257677 0.833368333515617 PRKDC 1 GO:0016572 histone phosphorylation 1/725 39/18722 0.786019728257677 0.833368333515617 BAZ1B 1 GO:0021587 cerebellum morphogenesis 1/725 39/18722 0.786019728257677 0.833368333515617 HSPA5 1 GO:0042417 dopamine metabolic process 1/725 39/18722 0.786019728257677 0.833368333515617 MAOA 1 GO:0043267 negative regulation of potassium ion transport 1/725 39/18722 0.786019728257677 0.833368333515617 CAV1 1 GO:0045923 positive regulation of fatty acid metabolic process 1/725 39/18722 0.786019728257677 0.833368333515617 ANXA1 1 GO:0051154 negative regulation of striated muscle cell differentiation 1/725 39/18722 0.786019728257677 0.833368333515617 YBX1 1 GO:0051931 regulation of sensory perception 1/725 39/18722 0.786019728257677 0.833368333515617 SLC9A1 1 GO:0002437 inflammatory response to antigenic stimulus 2/725 74/18722 0.786433874053912 0.833497079989915 RBPJ/HMGB1 2 GO:0007224 smoothened signaling pathway 4/725 138/18722 0.786634450714491 0.833497079989915 DLG5/GLI3/GPC3/HES1 4 GO:0009582 detection of abiotic stimulus 4/725 138/18722 0.786634450714491 0.833497079989915 OPN3/NMT1/GNAQ/CDS1 4 GO:0006323 DNA packaging 6/725 199/18722 0.78723995386719 0.833964331484386 NASP/NPM1/ATRX/HP1BP3/BRD2/HMGB1 6 GO:0071356 cellular response to tumor necrosis factor 7/725 229/18722 0.787965370339481 0.834558391611122 KRT8/KRT18/TMSB4X/NFE2L2/HSPA1A/EIF5A/CYBA 7 GO:0071868 cellular response to monoamine stimulus 3/725 107/18722 0.788748943080636 0.835039346799445 APP/PDE4B/SLC9A1 3 GO:0071870 cellular response to catecholamine stimulus 3/725 107/18722 0.788748943080636 0.835039346799445 APP/PDE4B/SLC9A1 3 GO:0099003 vesicle-mediated transport in synapse 6/725 200/18722 0.791169692682827 0.837427265025944 CALM1/ACTG1/ROCK1/SYT7/VAMP2/RAB11A 6 GO:1903363 negative regulation of cellular protein catabolic process 2/725 75/18722 0.792649045493145 0.838663783721712 EIF3H/SDCBP 2 GO:0098659 inorganic cation import across plasma membrane 3/725 108/18722 0.793962338304484 0.838663783721712 SLC39A10/SLC9A1/DLG1 3 GO:0099587 inorganic ion import across plasma membrane 3/725 108/18722 0.793962338304484 0.838663783721712 SLC39A10/SLC9A1/DLG1 3 GO:0140053 mitochondrial gene expression 3/725 108/18722 0.793962338304484 0.838663783721712 TFAM/IARS2/CHCHD10 3 GO:0002714 positive regulation of B cell mediated immunity 1/725 40/18722 0.794323303540725 0.838663783721712 TFRC 1 GO:0002891 positive regulation of immunoglobulin mediated immune response 1/725 40/18722 0.794323303540725 0.838663783721712 TFRC 1 GO:0007339 binding of sperm to zona pellucida 1/725 40/18722 0.794323303540725 0.838663783721712 ALDOA 1 GO:0009069 serine family amino acid metabolic process 1/725 40/18722 0.794323303540725 0.838663783721712 GLDC 1 GO:0009187 cyclic nucleotide metabolic process 1/725 40/18722 0.794323303540725 0.838663783721712 PDE4B 1 GO:0032892 positive regulation of organic acid transport 1/725 40/18722 0.794323303540725 0.838663783721712 ITGB1 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/725 40/18722 0.794323303540725 0.838663783721712 LGR4 1 GO:1901661 quinone metabolic process 1/725 40/18722 0.794323303540725 0.838663783721712 AKR1B1 1 GO:0046890 regulation of lipid biosynthetic process 5/725 171/18722 0.796414292538461 0.840696386688351 ORMDL1/SF1/ANXA1/IDH1/RDH10 5 GO:0002429 immune response-activating cell surface receptor signaling pathway 9/725 291/18722 0.798411568857696 0.84222824056297 SLC39A10/KCNN4/EZR/PDE4B/BCL2/HRAS/RIPK2/PHPT1/CBLB 9 GO:0002757 immune response-activating signal transduction 9/725 291/18722 0.798411568857696 0.84222824056297 SLC39A10/KCNN4/EZR/PDE4B/BCL2/HRAS/RIPK2/PHPT1/CBLB 9 GO:0008652 cellular amino acid biosynthetic process 2/725 76/18722 0.798703968439783 0.84222824056297 GLUL/MTR 2 GO:0032720 negative regulation of tumor necrosis factor production 2/725 76/18722 0.798703968439783 0.84222824056297 DICER1/ARG2 2 GO:0017157 regulation of exocytosis 6/725 202/18722 0.798862375345583 0.84222824056297 ANXA1/CALM1/SYT7/VAMP2/ARF1/SDCBP 6 GO:0019722 calcium-mediated signaling 6/725 202/18722 0.798862375345583 0.84222824056297 EGFR/CALM1/PPP1R9A/NFAT5/SLC9A1/GSTO1 6 GO:0042742 defense response to bacterium 11/725 350/18722 0.800560837985214 0.843843395247879 S100A9/RBPJ/GRN/RPS19/COLEC12/CEBPB/RIPK2/RAB1A/SERPINE1/ARG2/CYBA 11 GO:0006418 tRNA aminoacylation for protein translation 1/725 41/18722 0.802305083057532 0.844628134167939 IARS2 1 GO:0044786 cell cycle DNA replication 1/725 41/18722 0.802305083057532 0.844628134167939 ATRX 1 GO:0050691 regulation of defense response to virus by host 1/725 41/18722 0.802305083057532 0.844628134167939 TRIM44 1 GO:0050892 intestinal absorption 1/725 41/18722 0.802305083057532 0.844628134167939 EZR 1 GO:1905521 regulation of macrophage migration 1/725 41/18722 0.802305083057532 0.844628134167939 MIF 1 GO:2000008 regulation of protein localization to cell surface 1/725 41/18722 0.802305083057532 0.844628134167939 GOPC 1 GO:0006643 membrane lipid metabolic process 6/725 203/18722 0.802625921921362 0.844790448135254 ORMDL1/PLPP3/HACD3/PSAP/HEXA/SPTSSA 6 GO:0009063 cellular amino acid catabolic process 3/725 110/18722 0.804067475960128 0.84613203978449 GLDC/GLUL/ARG2 3 GO:0140056 organelle localization by membrane tethering 2/725 77/18722 0.804601713215726 0.846518489890102 CALM1/RALB 2 GO:0046467 membrane lipid biosynthetic process 4/725 142/18722 0.80481156281319 0.846563563374156 ORMDL1/PLPP3/HACD3/SPTSSA 4 GO:0006887 exocytosis 11/725 352/18722 0.806323364371483 0.847977828630507 ANXA1/CALM1/RAB11FIP1/SYT7/EXOC1/RALB/VAMP2/RAB11A/ARF1/ARL8B/SDCBP 11 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 3/725 111/18722 0.808961937327138 0.84973946921886 EGFR/CAT/FLT1 3 GO:0071867 response to monoamine 3/725 111/18722 0.808961937327138 0.84973946921886 APP/PDE4B/SLC9A1 3 GO:0071869 response to catecholamine 3/725 111/18722 0.808961937327138 0.84973946921886 APP/PDE4B/SLC9A1 3 GO:0019432 triglyceride biosynthetic process 1/725 42/18722 0.80997752108458 0.84973946921886 LPIN2 1 GO:0032691 negative regulation of interleukin-1 beta production 1/725 42/18722 0.80997752108458 0.84973946921886 SERPINB1 1 GO:0071312 cellular response to alkaloid 1/725 42/18722 0.80997752108458 0.84973946921886 MDM2 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/725 42/18722 0.80997752108458 0.84973946921886 RHOA 1 GO:0090317 negative regulation of intracellular protein transport 1/725 42/18722 0.80997752108458 0.84973946921886 LMAN1 1 GO:1904037 positive regulation of epithelial cell apoptotic process 1/725 42/18722 0.80997752108458 0.84973946921886 PDCD4 1 GO:0032371 regulation of sterol transport 2/725 78/18722 0.81034535296981 0.84973946921886 CAV1/LRP1 2 GO:0032374 regulation of cholesterol transport 2/725 78/18722 0.81034535296981 0.84973946921886 CAV1/LRP1 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2/725 78/18722 0.81034535296981 0.84973946921886 ANXA1/RHOA 2 GO:1901616 organic hydroxy compound catabolic process 2/725 78/18722 0.81034535296981 0.84973946921886 TPI1/MAOA 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 2/725 78/18722 0.81034535296981 0.84973946921886 DICER1/ARG2 2 GO:0010324 membrane invagination 4/725 144/18722 0.813417884834146 0.852784955165313 RHOA/CDC42/RAC1/ARF1 4 GO:0002526 acute inflammatory response 3/725 112/18722 0.813752844328859 0.852959712138748 IL6ST/ASH1L/CEBPB 3 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 2/725 79/18722 0.815937958861312 0.854974753814497 CAT/FLT1 2 GO:1901617 organic hydroxy compound biosynthetic process 7/725 237/18722 0.816012597939344 0.854974753814497 AKR1B1/DHCR24/ISYNA1/SLC27A2/OPN3/MFSD12/HSD17B1 7 GO:0050728 negative regulation of inflammatory response 5/725 176/18722 0.816258203898287 0.855055349361524 ISL1/GRN/RPS19/ASH1L/SERPINF1 5 GO:0046717 acid secretion 1/725 43/18722 0.817352590528567 0.855756923366273 SGK1 1 GO:0098815 modulation of excitatory postsynaptic potential 1/725 43/18722 0.817352590528567 0.855756923366273 APP 1 GO:0007269 neurotransmitter secretion 4/725 145/18722 0.817603231379534 0.855756923366273 CALM1/PPP1R9A/SYT7/VAMP2 4 GO:0099643 signal release from synapse 4/725 145/18722 0.817603231379534 0.855756923366273 CALM1/PPP1R9A/SYT7/VAMP2 4 GO:0019221 cytokine-mediated signaling pathway 15/725 472/18722 0.81808000500677 0.856079179475499 KRT8/CSF3R/CAV1/KRT18/LIFR/TMSB4X/IL6ST/SOCS1/TRIM44/P4HB/CSNK2B/GHR/HSPA1A/EIF5A/RIPK2 15 GO:0051259 protein complex oligomerization 7/725 238/18722 0.819307175158674 0.857186392338353 ALDOA/MIF/FUS/HOMER1/SLC9A1/HGSNAT/B2M 7 GO:0006378 mRNA polyadenylation 1/725 44/18722 0.824441801507034 0.861491546452104 APP 1 GO:0031295 T cell costimulation 1/725 44/18722 0.824441801507034 0.861491546452104 CAV1 1 GO:0032007 negative regulation of TOR signaling 1/725 44/18722 0.824441801507034 0.861491546452104 PDCD6 1 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1/725 44/18722 0.824441801507034 0.861491546452104 SERPINB9 1 GO:0043039 tRNA aminoacylation 1/725 44/18722 0.824441801507034 0.861491546452104 IARS2 1 GO:0044058 regulation of digestive system process 1/725 44/18722 0.824441801507034 0.861491546452104 SGK1 1 GO:0007416 synapse assembly 5/725 179/18722 0.827401548594582 0.864350094762634 DLG5/APP/CDH1/PPP1R9A/SDCBP 5 GO:0042471 ear morphogenesis 3/725 115/18722 0.827518447402459 0.864350094762634 TRIOBP/NIPBL/TFAP2A 3 GO:0006110 regulation of glycolytic process 1/725 45/18722 0.831256219212752 0.866793186457198 APP 1 GO:0010824 regulation of centrosome duplication 1/725 45/18722 0.831256219212752 0.866793186457198 NPM1 1 GO:0032309 icosanoid secretion 1/725 45/18722 0.831256219212752 0.866793186457198 ANXA1 1 GO:0043038 amino acid activation 1/725 45/18722 0.831256219212752 0.866793186457198 IARS2 1 GO:0043631 RNA polyadenylation 1/725 45/18722 0.831256219212752 0.866793186457198 APP 1 GO:0071354 cellular response to interleukin-6 1/725 45/18722 0.831256219212752 0.866793186457198 IL6ST 1 GO:0001910 regulation of leukocyte mediated cytotoxicity 2/725 82/18722 0.831840164093368 0.866793186457198 SERPINB9/B2M 2 GO:0002312 B cell activation involved in immune response 2/725 82/18722 0.831840164093368 0.866793186457198 TFRC/HSPD1 2 GO:0007032 endosome organization 2/725 82/18722 0.831840164093368 0.866793186457198 HOOK3/RAB11A 2 GO:0043242 negative regulation of protein-containing complex disassembly 2/725 82/18722 0.831840164093368 0.866793186457198 TRIOBP/CAPZB 2 GO:0046889 positive regulation of lipid biosynthetic process 2/725 82/18722 0.831840164093368 0.866793186457198 ANXA1/RDH10 2 GO:0031123 RNA 3'-end processing 3/725 116/18722 0.831909420421043 0.866793186457198 APP/RPS21/DHX36 3 GO:0045834 positive regulation of lipid metabolic process 4/725 149/18722 0.833578616121034 0.868353885145401 ANXA1/RDH10/CDC42/FLT1 4 GO:0030258 lipid modification 6/725 212/18722 0.834076177045167 0.868693680181211 PLPP3/SLC27A2/CROT/ADH5/HADHA/ECHDC2 6 GO:0099504 synaptic vesicle cycle 5/725 181/18722 0.83452165723865 0.868979104466458 CALM1/ACTG1/ROCK1/SYT7/VAMP2 5 GO:0001510 RNA methylation 2/725 83/18722 0.836859157771047 0.870254314066052 ZC3H13/CMTR1 2 GO:0007019 microtubule depolymerization 1/725 46/18722 0.837806481089433 0.870254314066052 CCSAP 1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1/725 46/18722 0.837806481089433 0.870254314066052 TENM3 1 GO:0010830 regulation of myotube differentiation 1/725 46/18722 0.837806481089433 0.870254314066052 BCL2 1 GO:0031294 lymphocyte costimulation 1/725 46/18722 0.837806481089433 0.870254314066052 CAV1 1 GO:0042398 cellular modified amino acid biosynthetic process 1/725 46/18722 0.837806481089433 0.870254314066052 NFE2L2 1 GO:0043462 regulation of ATPase activity 1/725 46/18722 0.837806481089433 0.870254314066052 PFN1 1 GO:0043616 keratinocyte proliferation 1/725 46/18722 0.837806481089433 0.870254314066052 SRSF6 1 GO:0044818 mitotic G2/M transition checkpoint 1/725 46/18722 0.837806481089433 0.870254314066052 CDKN1A 1 GO:0046839 phospholipid dephosphorylation 1/725 46/18722 0.837806481089433 0.870254314066052 PLPP3 1 GO:0071827 plasma lipoprotein particle organization 1/725 46/18722 0.837806481089433 0.870254314066052 ARF1 1 GO:0090329 regulation of DNA-dependent DNA replication 1/725 46/18722 0.837806481089433 0.870254314066052 ATRX 1 GO:0002088 lens development in camera-type eye 2/725 84/18722 0.841742299551218 0.873984374523787 DLG1/KDM5B 2 GO:0009953 dorsal/ventral pattern formation 2/725 84/18722 0.841742299551218 0.873984374523787 GLI3/DDIT3 2 GO:0001754 eye photoreceptor cell differentiation 1/725 47/18722 0.844102813345277 0.874643736886184 RDH13 1 GO:0006998 nuclear envelope organization 1/725 47/18722 0.844102813345277 0.874643736886184 NEK6 1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1/725 47/18722 0.844102813345277 0.874643736886184 HSPA1A 1 GO:0016073 snRNA metabolic process 1/725 47/18722 0.844102813345277 0.874643736886184 NOP10 1 GO:0032008 positive regulation of TOR signaling 1/725 47/18722 0.844102813345277 0.874643736886184 SLC38A9 1 GO:0032369 negative regulation of lipid transport 1/725 47/18722 0.844102813345277 0.874643736886184 ITGAV 1 GO:0043114 regulation of vascular permeability 1/725 47/18722 0.844102813345277 0.874643736886184 PLEC 1 GO:0045601 regulation of endothelial cell differentiation 1/725 47/18722 0.844102813345277 0.874643736886184 ROCK1 1 GO:0090279 regulation of calcium ion import 1/725 47/18722 0.844102813345277 0.874643736886184 HOMER1 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/725 47/18722 0.844102813345277 0.874643736886184 APELA 1 GO:0010507 negative regulation of autophagy 2/725 85/18722 0.84649256668218 0.876761508073553 MET/BCL2 2 GO:0097194 execution phase of apoptosis 2/725 85/18722 0.84649256668218 0.876761508073553 DICER1/CFLAR 2 GO:0002715 regulation of natural killer cell mediated immunity 1/725 48/18722 0.850155046829865 0.87983583756239 SERPINB9 1 GO:0044458 motile cilium assembly 1/725 48/18722 0.850155046829865 0.87983583756239 NEURL1 1 GO:0045912 negative regulation of carbohydrate metabolic process 1/725 48/18722 0.850155046829865 0.87983583756239 CLTC 1 GO:0090199 regulation of release of cytochrome c from mitochondria 1/725 48/18722 0.850155046829865 0.87983583756239 PMAIP1 1 GO:0046928 regulation of neurotransmitter secretion 2/725 86/18722 0.851112909891952 0.880647344405451 CALM1/PPP1R9A 2 GO:0045088 regulation of innate immune response 6/725 218/18722 0.852716554071857 0.882126573998009 SERPINB9/PRKDC/GRN/RPS19/SOCS1/HMGB1 6 GO:1901879 regulation of protein depolymerization 2/725 87/18722 0.855606250978042 0.883151897643601 TRIOBP/CAPZB 2 GO:0006953 acute-phase response 1/725 49/18722 0.855972632298878 0.883151897643601 CEBPB 1 GO:0008206 bile acid metabolic process 1/725 49/18722 0.855972632298878 0.883151897643601 SLC27A2 1 GO:0009066 aspartate family amino acid metabolic process 1/725 49/18722 0.855972632298878 0.883151897643601 MTR 1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1/725 49/18722 0.855972632298878 0.883151897643601 SKP1 1 GO:0032692 negative regulation of interleukin-1 production 1/725 49/18722 0.855972632298878 0.883151897643601 SERPINB1 1 GO:0042304 regulation of fatty acid biosynthetic process 1/725 49/18722 0.855972632298878 0.883151897643601 ANXA1 1 GO:0042461 photoreceptor cell development 1/725 49/18722 0.855972632298878 0.883151897643601 RDH13 1 GO:0046605 regulation of centrosome cycle 1/725 49/18722 0.855972632298878 0.883151897643601 NPM1 1 GO:0051445 regulation of meiotic cell cycle 1/725 49/18722 0.855972632298878 0.883151897643601 DUSP1 1 GO:0070741 response to interleukin-6 1/725 49/18722 0.855972632298878 0.883151897643601 IL6ST 1 GO:0072666 establishment of protein localization to vacuole 1/725 49/18722 0.855972632298878 0.883151897643601 HSPA8 1 GO:1990573 potassium ion import across plasma membrane 1/725 49/18722 0.855972632298878 0.883151897643601 DLG1 1 GO:0019730 antimicrobial humoral response 3/725 122/18722 0.856283831870171 0.883293191646296 GAPDH/S100A9/RPS19 3 GO:0030101 natural killer cell activation 2/725 88/18722 0.859975480623097 0.885856234615108 PBX1/SNX27 2 GO:0050829 defense response to Gram-negative bacterium 2/725 88/18722 0.859975480623097 0.885856234615108 RPS19/SERPINE1 2 GO:0000387 spliceosomal snRNP assembly 1/725 50/18722 0.861564655090251 0.885856234615108 SNRPD2 1 GO:0002448 mast cell mediated immunity 1/725 50/18722 0.861564655090251 0.885856234615108 SERPINB9 1 GO:0002639 positive regulation of immunoglobulin production 1/725 50/18722 0.861564655090251 0.885856234615108 TFRC 1 GO:0007140 male meiotic nuclear division 1/725 50/18722 0.861564655090251 0.885856234615108 SLC2A8 1 GO:0015872 dopamine transport 1/725 50/18722 0.861564655090251 0.885856234615108 SYT7 1 GO:0019083 viral transcription 1/725 50/18722 0.861564655090251 0.885856234615108 JUN 1 GO:0038202 TORC1 signaling 1/725 50/18722 0.861564655090251 0.885856234615108 LARP1 1 GO:0043628 ncRNA 3'-end processing 1/725 50/18722 0.861564655090251 0.885856234615108 RPS21 1 GO:0046460 neutral lipid biosynthetic process 1/725 50/18722 0.861564655090251 0.885856234615108 LPIN2 1 GO:0046463 acylglycerol biosynthetic process 1/725 50/18722 0.861564655090251 0.885856234615108 LPIN2 1 GO:0051646 mitochondrion localization 1/725 50/18722 0.861564655090251 0.885856234615108 ARMCX3 1 GO:0071709 membrane assembly 1/725 50/18722 0.861564655090251 0.885856234615108 CAV1 1 GO:0071825 protein-lipid complex subunit organization 1/725 50/18722 0.861564655090251 0.885856234615108 ARF1 1 GO:0090102 cochlea development 1/725 50/18722 0.861564655090251 0.885856234615108 HES1 1 GO:0034612 response to tumor necrosis factor 7/725 253/18722 0.863373479679178 0.887536030925523 KRT8/KRT18/TMSB4X/NFE2L2/HSPA1A/EIF5A/CYBA 7 GO:0002768 immune response-regulating cell surface receptor signaling pathway 9/725 315/18722 0.864731894370349 0.888752224769525 SLC39A10/KCNN4/EZR/PDE4B/BCL2/HRAS/RIPK2/PHPT1/CBLB 9 GO:0060632 regulation of microtubule-based movement 1/725 51/18722 0.866939849234401 0.890840887040174 CCSAP 1 GO:0060294 cilium movement involved in cell motility 3/725 125/18722 0.867270595724525 0.891000131683749 NEURL1/ASH1L/CCSAP 3 GO:0035278 miRNA mediated inhibition of translation 2/725 90/18722 0.868353001111569 0.891750681246869 TNRC6B/AGO2 2 GO:0040033 negative regulation of translation, ncRNA-mediated 2/725 90/18722 0.868353001111569 0.891750681246869 TNRC6B/AGO2 2 GO:0035176 social behavior 1/725 52/18722 0.872106611020329 0.895328572799282 SLC6A4 1 GO:0008037 cell recognition 6/725 225/18722 0.872260515152566 0.895328572799282 ALDOA/SPESP1/APP/COLEC12/DLG1/RTN4 6 GO:0045974 regulation of translation, ncRNA-mediated 2/725 91/18722 0.87236690097764 0.895328572799282 TNRC6B/AGO2 2 GO:0002449 lymphocyte mediated immunity 10/725 350/18722 0.87499265807551 0.897841656636591 SERPINB9/CD46/TFRC/KIF5B/HSPD1/CTSC/CD55/HMGB1/ARL8B/B2M 10 GO:0031348 negative regulation of defense response 7/725 258/18722 0.875954024751702 0.898646215637802 SERPINB9/ISL1/GRN/RPS19/ASH1L/SERPINF1/ARG2 7 GO:0070509 calcium ion import 2/725 92/18722 0.876267904449121 0.898786322875879 HOMER1/AFG3L2 2 GO:0032784 regulation of DNA-templated transcription, elongation 1/725 53/18722 0.877073012038554 0.899066349448621 BRD4 1 GO:0043113 receptor clustering 1/725 53/18722 0.877073012038554 0.899066349448621 DLG1 1 GO:0071715 icosanoid transport 1/725 53/18722 0.877073012038554 0.899066349448621 ANXA1 1 GO:0006639 acylglycerol metabolic process 3/725 128/18722 0.87751056117653 0.899333003357022 CAV1/LPIN2/CAT 3 GO:1901605 alpha-amino acid metabolic process 5/725 195/18722 0.877878638358977 0.899528364229159 GLDC/GLUL/RIMKLB/MTR/ARG2 5 GO:0019217 regulation of fatty acid metabolic process 2/725 93/18722 0.880058720846561 0.90157996280744 CAV1/ANXA1 2 GO:0006638 neutral lipid metabolic process 3/725 129/18722 0.880764801419452 0.902120989774743 CAV1/LPIN2/CAT 3 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/725 54/18722 0.881846811721025 0.902499795803326 APELA 1 GO:0006968 cellular defense response 1/725 54/18722 0.881846811721025 0.902499795803326 ITGB1 1 GO:0051703 biological process involved in intraspecies interaction between organisms 1/725 54/18722 0.881846811721025 0.902499795803326 SLC6A4 1 GO:2000300 regulation of synaptic vesicle exocytosis 1/725 54/18722 0.881846811721025 0.902499795803326 CALM1 1 GO:0019080 viral gene expression 2/725 94/18722 0.883742019287495 0.9040963782076 JUN/FUT8 2 GO:0007098 centrosome cycle 3/725 130/18722 0.883941931425699 0.9040963782076 CEP152/NPM1/UVRAG 3 GO:0030534 adult behavior 3/725 130/18722 0.883941931425699 0.9040963782076 APP/HOMER1/PUM1 3 GO:0045055 regulated exocytosis 6/725 230/18722 0.884855762137905 0.904848468484374 CALM1/RAB11FIP1/SYT7/VAMP2/ARF1/ARL8B 6 GO:0002067 glandular epithelial cell differentiation 1/725 55/18722 0.886435469397383 0.905550462389225 HES1 1 GO:0044091 membrane biogenesis 1/725 55/18722 0.886435469397383 0.905550462389225 CAV1 1 GO:0046164 alcohol catabolic process 1/725 55/18722 0.886435469397383 0.905550462389225 TPI1 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/725 55/18722 0.886435469397383 0.905550462389225 NEURL1 1 GO:1905517 macrophage migration 1/725 55/18722 0.886435469397383 0.905550462389225 MIF 1 GO:0045089 positive regulation of innate immune response 3/725 131/18722 0.887043395898621 0.905920682624452 PRKDC/RPS19/HMGB1 3 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 10/725 356/18722 0.887155310425682 0.905920682624452 CD46/TFRC/HSPD1/CTSC/ANXA1/CD55/HRAS/RIPK2/HMGB1/B2M 10 GO:0006637 acyl-CoA metabolic process 2/725 96/18722 0.890796532176153 0.907678223957224 ACSS1/MPC2 2 GO:0035383 thioester metabolic process 2/725 96/18722 0.890796532176153 0.907678223957224 ACSS1/MPC2 2 GO:0042472 inner ear morphogenesis 2/725 96/18722 0.890796532176153 0.907678223957224 TRIOBP/TFAP2A 2 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/725 56/18722 0.890846155886208 0.907678223957224 B2M 1 GO:0002886 regulation of myeloid leukocyte mediated immunity 1/725 56/18722 0.890846155886208 0.907678223957224 DHX36 1 GO:0006687 glycosphingolipid metabolic process 1/725 56/18722 0.890846155886208 0.907678223957224 HEXA 1 GO:0045071 negative regulation of viral genome replication 1/725 56/18722 0.890846155886208 0.907678223957224 MPHOSPH8 1 GO:0045599 negative regulation of fat cell differentiation 1/725 56/18722 0.890846155886208 0.907678223957224 DDIT3 1 GO:0050433 regulation of catecholamine secretion 1/725 56/18722 0.890846155886208 0.907678223957224 SYT7 1 GO:0055078 sodium ion homeostasis 1/725 56/18722 0.890846155886208 0.907678223957224 SLC9A1 1 GO:0070534 protein K63-linked ubiquitination 1/725 56/18722 0.890846155886208 0.907678223957224 SASH1 1 GO:0009451 RNA modification 4/725 167/18722 0.891666221742462 0.908331205388372 RBM47/ZC3H13/CMTR1/NOP10 4 GO:0010565 regulation of cellular ketone metabolic process 3/725 133/18722 0.893025054602614 0.909532650548654 CAV1/ANXA1/RDH10 3 GO:1990868 response to chemokine 2/725 97/18722 0.894172875934938 0.910335872286443 DUSP1/RHOA 2 GO:1990869 cellular response to chemokine 2/725 97/18722 0.894172875934938 0.910335872286443 DUSP1/RHOA 2 GO:0006695 cholesterol biosynthetic process 1/725 57/18722 0.895085764639155 0.910899365781143 DHCR24 1 GO:1902653 secondary alcohol biosynthetic process 1/725 57/18722 0.895085764639155 0.910899365781143 DHCR24 1 GO:0007131 reciprocal meiotic recombination 1/725 58/18722 0.899160922455207 0.914128904116615 RAD50 1 GO:0010043 response to zinc ion 1/725 58/18722 0.899160922455207 0.914128904116615 PARP1 1 GO:0032387 negative regulation of intracellular transport 1/725 58/18722 0.899160922455207 0.914128904116615 LMAN1 1 GO:0034340 response to type I interferon 1/725 58/18722 0.899160922455207 0.914128904116615 SETD2 1 GO:0140527 reciprocal homologous recombination 1/725 58/18722 0.899160922455207 0.914128904116615 RAD50 1 GO:1903305 regulation of regulated secretory pathway 3/725 136/18722 0.901465533058871 0.916288106491963 CALM1/SYT7/ARF1 3 GO:0033013 tetrapyrrole metabolic process 1/725 59/18722 0.903077999781609 0.917375226631859 MTR 1 GO:0048278 vesicle docking 1/725 59/18722 0.903077999781609 0.917375226631859 RALB 1 GO:0051055 negative regulation of lipid biosynthetic process 1/725 59/18722 0.903077999781609 0.917375226631859 ORMDL1 1 GO:0060079 excitatory postsynaptic potential 2/725 100/18722 0.903728124963287 0.917851706158867 APP/PPP1R9A 2 GO:0007586 digestion 3/725 137/18722 0.904142711084539 0.918088822613687 KCNN4/EZR/SGK1 3 GO:0001539 cilium or flagellum-dependent cell motility 3/725 138/18722 0.906754005759429 0.919848212485773 NEURL1/ASH1L/CCSAP 3 GO:0060285 cilium-dependent cell motility 3/725 138/18722 0.906754005759429 0.919848212485773 NEURL1/ASH1L/CCSAP 3 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 1/725 60/18722 0.906843120617399 0.919848212485773 CDKN1A 1 GO:0035825 homologous recombination 1/725 60/18722 0.906843120617399 0.919848212485773 RAD50 1 GO:0051965 positive regulation of synapse assembly 1/725 60/18722 0.906843120617399 0.919848212485773 DLG5 1 GO:0016064 immunoglobulin mediated immune response 5/725 207/18722 0.906964167686702 0.919848212485773 CD46/TFRC/HSPD1/CD55/B2M 5 GO:0045833 negative regulation of lipid metabolic process 2/725 102/18722 0.909644150205244 0.922381715821241 ORMDL1/PIP4K2A 2 GO:0043966 histone H3 acetylation 1/725 61/18722 0.910462172034845 0.92265748701412 ZNF451 1 GO:0050994 regulation of lipid catabolic process 1/725 61/18722 0.910462172034845 0.92265748701412 IDH1 1 GO:1905515 non-motile cilium assembly 1/725 61/18722 0.910462172034845 0.92265748701412 CEP350 1 GO:0046165 alcohol biosynthetic process 3/725 140/18722 0.911784299291159 0.923812635040353 AKR1B1/DHCR24/ISYNA1 3 GO:0019724 B cell mediated immunity 5/725 210/18722 0.913216399321911 0.92507872265443 CD46/TFRC/HSPD1/CD55/B2M 5 GO:0007588 excretion 1/725 62/18722 0.913940813333529 0.925442665359101 NFAT5 1 GO:1902750 negative regulation of cell cycle G2/M phase transition 1/725 62/18722 0.913940813333529 0.925442665359101 CDKN1A 1 GO:0031343 positive regulation of cell killing 1/725 63/18722 0.917284484841202 0.928642910657091 B2M 1 GO:0031023 microtubule organizing center organization 3/725 143/18722 0.918868666853141 0.930060956924635 CEP152/NPM1/UVRAG 3 GO:0099565 chemical synaptic transmission, postsynaptic 2/725 106/18722 0.920468698120656 0.930966973783948 APP/PPP1R9A 2 GO:0016126 sterol biosynthetic process 1/725 64/18722 0.920498416375054 0.930966973783948 DHCR24 1 GO:0046530 photoreceptor cell differentiation 1/725 64/18722 0.920498416375054 0.930966973783948 RDH13 1 GO:0048247 lymphocyte chemotaxis 1/725 64/18722 0.920498416375054 0.930966973783948 PLEC 1 GO:0002443 leukocyte mediated immunity 12/725 440/18722 0.923266818088584 0.933580590642536 SERPINB9/CD46/TFRC/KIF5B/HSPD1/CTSC/DHX36/CD55/VAMP2/HMGB1/ARL8B/B2M 12 GO:0061512 protein localization to cilium 1/725 65/18722 0.923587635376452 0.933718732294223 ARF4 1 GO:0006958 complement activation, classical pathway 2/725 108/18722 0.925411896921199 0.935376451743481 CD46/CD55 2 GO:0051260 protein homooligomerization 4/725 182/18722 0.925660332311186 0.935441033589593 ALDOA/MIF/FUS/B2M 4 GO:1905953 negative regulation of lipid localization 1/725 66/18722 0.926556974731765 0.936160515231277 ITGAV 1 GO:0006959 humoral immune response 8/725 317/18722 0.927552166626355 0.93697926118553 GAPDH/CD46/S100A9/RBPJ/RPS19/TFEB/BCL2/CD55 8 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/725 67/18722 0.929411080291342 0.938670007172108 ANXA1 1 GO:0030317 flagellated sperm motility 2/725 110/18722 0.930064315466066 0.938955589543415 NEURL1/ASH1L 2 GO:0097722 sperm motility 2/725 110/18722 0.930064315466066 0.938955589543415 NEURL1/ASH1L 2 GO:0006805 xenobiotic metabolic process 2/725 111/18722 0.932286377450267 0.941011478951693 CYP2J2/GSTO1 2 GO:0050688 regulation of defense response to virus 1/725 69/18722 0.934791281338286 0.943164212799318 TRIM44 1 GO:0050810 regulation of steroid biosynthetic process 1/725 69/18722 0.934791281338286 0.943164212799318 SF1 1 GO:0006261 DNA-dependent DNA replication 3/725 151/18722 0.935294210962995 0.943483851815208 ATRX/BOD1L1/PURA 3 GO:0071347 cellular response to interleukin-1 2/725 113/18722 0.936531621300669 0.944544128207937 USP10/CEBPB 2 GO:0090501 RNA phosphodiester bond hydrolysis 3/725 152/18722 0.937116641766044 0.944946142254243 RPS21/DICER1/AGO2 3 GO:0002534 cytokine production involved in inflammatory response 1/725 72/18722 0.942103501167251 0.949596867650983 PDCD4 1 GO:1900015 regulation of cytokine production involved in inflammatory response 1/725 72/18722 0.942103501167251 0.949596867650983 PDCD4 1 GO:0043299 leukocyte degranulation 1/725 73/18722 0.944354169352438 0.951676199691354 VAMP2 1 GO:0071774 response to fibroblast growth factor 2/725 120/18722 0.949486290574125 0.956657922265999 IER2/KDM5B 2 GO:0032543 mitochondrial translation 1/725 76/18722 0.950595334589272 0.957394744890327 IARS2 1 GO:0140029 exocytic process 1/725 76/18722 0.950595334589272 0.957394744890327 RALB 1 GO:0002455 humoral immune response mediated by circulating immunoglobulin 2/725 121/18722 0.951117174467297 0.957730027289378 CD46/CD55 2 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1/725 78/18722 0.95436267926976 0.960807233608423 PSAP 1 GO:0002440 production of molecular mediator of immune response 7/725 308/18722 0.956555396506347 0.962823531550968 TFRC/HSPD1/PRKDC/DHX36/CD55/SLC7A5/B2M 7 GO:0001960 negative regulation of cytokine-mediated signaling pathway 1/725 81/18722 0.959482621550351 0.965578203025358 CAV1 1 GO:0006911 phagocytosis, engulfment 2/725 127/18722 0.959894910542099 0.965801369896368 CDC42/RAC1 2 GO:0035082 axoneme assembly 1/725 82/18722 0.961058454358462 0.966780175658473 NEURL1 1 GO:0007127 meiosis I 2/725 129/18722 0.962469335591169 0.968007353593579 RAD50/SLC2A8 2 GO:0006956 complement activation 2/725 130/18722 0.963696326281255 0.96904913269583 CD46/CD55 2 GO:0050853 B cell receptor signaling pathway 2/725 131/18722 0.964884743806567 0.970051718832901 SLC39A10/BCL2 2 GO:0006520 cellular amino acid metabolic process 6/725 284/18722 0.966000026616918 0.970980395582224 GLDC/IARS2/GLUL/RIMKLB/MTR/ARG2 6 GO:0060761 negative regulation of response to cytokine stimulus 1/725 86/18722 0.966772998953236 0.971564697005145 CAV1 1 GO:0003341 cilium movement 3/725 175/18722 0.967924183644095 0.972528778373027 NEURL1/ASH1L/CCSAP 3 GO:0007601 visual perception 4/725 215/18722 0.969117832776966 0.973500164183984 EFEMP1/RDH10/TACSTD2/TIMP3 4 GO:0061982 meiosis I cell cycle process 2/725 135/18722 0.969275069764563 0.973500164183984 RAD50/SLC2A8 2 GO:0002377 immunoglobulin production 4/725 216/18722 0.969957360161292 0.973992444266559 TFRC/HSPD1/PRKDC/B2M 4 GO:0050953 sensory perception of light stimulus 4/725 219/18722 0.972349822070327 0.976201475158346 EFEMP1/RDH10/TACSTD2/TIMP3 4 GO:0033108 mitochondrial respiratory chain complex assembly 1/725 93/18722 0.974832431697617 0.978500118074301 TFAM 1 GO:0051321 meiotic cell cycle 5/725 261/18722 0.975503465429454 0.978786038452475 DUSP1/ATRX/RAD50/SLC2A8/NUMA1 5 GO:0090305 nucleic acid phosphodiester bond hydrolysis 5/725 261/18722 0.975503465429454 0.978786038452475 RPS21/N4BP2/RAD50/DICER1/AGO2 5 GO:0060271 cilium assembly 7/725 337/18722 0.977739828680881 0.980835779058655 DYNLL1/GALNT11/LAMA5/NEURL1/DYNLL2/CEP350/ARF4 7 GO:0006664 glycolipid metabolic process 1/725 100/18722 0.980939024984988 0.983461217889419 HEXA 1 GO:0006910 phagocytosis, recognition 1/725 100/18722 0.980939024984988 0.983461217889419 COLEC12 1 GO:0019218 regulation of steroid metabolic process 1/725 100/18722 0.980939024984988 0.983461217889419 SF1 1 GO:0050830 defense response to Gram-positive bacterium 1/725 101/18722 0.981681115355833 0.983816048584167 RIPK2 1 GO:1903509 liposaccharide metabolic process 1/725 101/18722 0.981681115355833 0.983816048584167 HEXA 1 GO:0062014 negative regulation of small molecule metabolic process 1/725 102/18722 0.982394352634552 0.984336227219716 PARP1 1 GO:0019932 second-messenger-mediated signaling 6/725 312/18722 0.982994435125018 0.984633826509535 EGFR/CALM1/PPP1R9A/NFAT5/SLC9A1/GSTO1 6 GO:0019233 sensory perception of pain 1/725 103/18722 0.983079857164087 0.984633826509535 SLC9A1 1 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1/725 104/18722 0.98373870584318 0.98509907149725 HOMER1 1 GO:1903046 meiotic cell cycle process 3/725 202/18722 0.985927826179227 0.987096217835769 ATRX/RAD50/SLC2A8 3 GO:0044344 cellular response to fibroblast growth factor stimulus 1/725 113/18722 0.988627071906246 0.989603204481193 KDM5B 1 GO:0090630 activation of GTPase activity 1/725 115/18722 0.989496002788978 0.990130543544252 SYDE1 1 GO:0044782 cilium organization 7/725 368/18722 0.989544551902777 0.990130543544252 DYNLL1/GALNT11/LAMA5/NEURL1/DYNLL2/CEP350/ARF4 7 GO:0006399 tRNA metabolic process 2/725 179/18722 0.993192765776722 0.993584789761635 IARS2/DICER1 2 GO:0140013 meiotic nuclear division 2/725 185/18722 0.994482096555868 0.994678324278156 RAD50/SLC2A8 2 GO:0007608 sensory perception of smell 1/725 456/18722 0.999999987975864 0.999999987975864 B3GNT2 1