ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0045296	cadherin binding	44/588	332/18367	1.11298633845567e-15	8.84824139072258e-13	AHNAK/EGFR/LDHA/RPL23A/HSPA5/MACF1/CDH1/ITGA6/CD46/ITGB1/RPL6/SLC3A2/PLEC/ALDOA/IQGAP1/BSG/RPL14/HSPA1A/SPTAN1/ENO1/SPTBN1/KTN1/ARGLU1/RPS26/RTN4/KIF5B/PKN2/CTNND1/WASF2/PKM/DNAJB1/SH3GLB2/TRIM29/TAGLN2/PFN1/HSPA8/S100P/RAN/YWHAE/EFHD2/RANBP1/SERBP1/CNN3/CTNNAL1	44
GO:0003735	structural constituent of ribosome	26/588	182/18367	1.63906011228557e-10	6.51526394633514e-08	RPS21/RPS20/RPL13A/RPS11/RPLP0/RPL27A/RPL31/RPL23A/RPS3A/RPS6/RPL6/RPL7/RPS16/RPL23/RPL14/RPS13/RPS25/RPL21/RPS17/RPS10/RPL9/RPS26/RPL4/UBA52/RPL17/RPS4Y1	26
GO:0001618	virus receptor activity	16/588	76/18367	1.81553077376432e-09	4.42171851529113e-07	EGFR/DAG1/ITGAV/CD46/ITGB1/BSG/ITGB5/HSPA1A/SLC1A5/SLC52A1/SLC52A2/DPP4/TFRC/CD81/CD55/CDK1	16
GO:0140272	exogenous protein binding	16/588	77/18367	2.22476403285088e-09	4.42171851529113e-07	EGFR/DAG1/ITGAV/CD46/ITGB1/BSG/ITGB5/HSPA1A/SLC1A5/SLC52A1/SLC52A2/DPP4/TFRC/CD81/CD55/CDK1	16
GO:0005178	integrin binding	20/588	144/18367	3.47203513165936e-08	5.52053585933838e-06	FBN1/LAMA5/ITGB4/EGFR/LAMB1/FBLN1/ITGAV/P4HB/ITGB1/UTRN/ITGB5/PLPP3/DST/FERMT1/JAM3/CD81/PPIA/TSPAN4/HMGB1/IGF2	20
GO:0098631	cell adhesion mediator activity	10/588	59/18367	1.60096604505904e-05	0.00212128000970323	BCAM/ITGB1/BSG/DSG2/JAM3/DSC2/DSP/TRIM29/NINJ1/CNN3	10
GO:0031994	insulin-like growth factor I binding	5/588	13/18367	3.43704423836384e-05	0.00390350024214179	LRP2/ITGB4/ITGAV/ITGA6/IGF1R	5
GO:0019838	growth factor binding	15/588	141/18367	4.72338317778094e-05	0.00469386203291981	LRP2/ITGB4/EGFR/NRP2/GLG1/ITGAV/CRIM1/ITGA6/LTBP1/TGFBR3/DUSP1/GPC1/ERBB3/IGF1R/IL6ST	15
GO:0140678	molecular function inhibitor activity	14/588	128/18367	6.18657345506307e-05	0.00522243043539924	RPS20/RPL23/ANXA5/DDIT3/PURA/CALM1/CAV1/ID1/RASA1/CALM2/DYNLL1/TXNIP/ANXA4/PHPT1	14
GO:0050840	extracellular matrix binding	9/588	56/18367	6.56909488729464e-05	0.00522243043539924	DAG1/ITGAV/BCAM/ADGRG1/ITGA6/TINAGL1/ITGB1/GPC1/SMOC1	9
GO:0008509	anion transmembrane transporter activity	24/588	314/18367	7.98686198291439e-05	0.00546585905580741	SLC26A2/CLDN4/SLC3A2/SLC2A1/SLC22A11/GABRE/SLC38A2/SLC1A5/SLC2A8/SLC52A1/SLC12A9/GJA1/SLC38A1/SLC9A1/SLC52A2/SLC19A1/SLC13A4/SLC16A12/SLC6A4/SLC38A9/MFSD10/FXYD3/VDAC1/CLIC3	24
GO:0035198	miRNA binding	7/588	34/18367	8.42616167889154e-05	0.00546585905580741	NEAT1/KCNQ1OT1/SOX4/HNRNPA1/YBX1/PUM1/HNRNPA2B1	7
GO:0003779	actin binding	30/588	440/18367	8.93788273276684e-05	0.00546585905580741	EGFR/DAG1/MACF1/IQGAP2/P4HB/ITGB1/UTRN/PLEC/SYNE2/ALDOA/IQGAP1/MYH10/SPTAN1/SPTBN1/DST/FERMT1/DIAPH1/SLC6A4/PHACTR2/CFL1/TMSB4X/WASF2/TRIOBP/MSRB2/TPM4/PFN1/TPM3/YWHAH/CNN3/CTNNAL1	30
GO:0097718	disordered domain specific binding	7/588	36/18367	0.000123694641852204	0.007024088590893	GAPDH/HSPA1A/GJA5/GJA1/CALM1/NCOA3/CALM2	7
GO:1901681	sulfur compound binding	21/588	265/18367	0.000133116961092651	0.00705519893791051	FBN1/LRP1/NRP2/CCDC80/APLP2/ADGRG1/APP/SOD3/TGFBR3/LRPAP1/ADAMTS1/PTPRF/CHST12/SMOC1/ILVBL/PPIA/PTGES2/BMP7/FSTL1/ACADVL/HADHA	21
GO:0051082	unfolded protein binding	13/588	122/18367	0.00014658546076914	0.00728346508196664	HSP90B1/HSPA5/LMAN1/HSPA1A/SERPINH1/SIL1/NPM1/PPIA/PET100/DNAJB1/CANX/PTGES3/HSPA8	13
GO:0043236	laminin binding	6/588	28/18367	0.000216617510567273	0.010130054170646	DAG1/BCAM/ITGA6/TINAGL1/ITGB1/GPC1	6
GO:0005520	insulin-like growth factor binding	6/588	29/18367	0.000265798554789088	0.0115102154254152	LRP2/ITGB4/ITGAV/CRIM1/ITGA6/IGF1R	6
GO:0097493	structural molecule activity conferring elasticity	4/588	11/18367	0.000286731202906694	0.0115102154254152	FBN1/FBN2/AHNAK/LAMC1	4
GO:0004867	serine-type endopeptidase inhibitor activity	11/588	98/18367	0.000296979598743115	0.0115102154254152	SPINT1/ITIH5/APLP2/CRIM1/APP/SERPINF1/SPINT2/SERPINH1/SERPINB9/SERPINB1/TFPI2	11
GO:0019843	rRNA binding	9/588	68/18367	0.000304043426331723	0.0115102154254152	RPS11/RPLP0/RPL23A/RPL23/RPS13/RPL9/NPM1/CIRBP/RPS4Y1	9
GO:0061134	peptidase regulator activity	18/588	230/18367	0.000456635748565468	0.0165011554595249	GAPDH/SPINT1/FBLN1/ITIH5/APLP2/CRIM1/APP/SERPINF1/SPINT2/CTSC/SERPINH1/ROCK1/GPC3/CAV1/TIMP3/SERPINB9/SERPINB1/TFPI2	18
GO:0072542	protein phosphatase activator activity	4/588	13/18367	0.000590286493819816	0.019666290442523	B3GAT3/PPP1R15A/CALM1/CALM2	4
GO:0061980	regulatory RNA binding	7/588	46/18367	0.000601490124365374	0.019666290442523	NEAT1/KCNQ1OT1/SOX4/HNRNPA1/YBX1/PUM1/HNRNPA2B1	7
GO:0031625	ubiquitin protein ligase binding	21/588	297/18367	0.000618436806368647	0.019666290442523	JUN/EGFR/HSPA5/RPL23/HSPA1A/ERBB3/RTN4/UBA52/POLR2A/TPI1/PSMD1/TRIOBP/ACTG1/HM13/NFKBIA/HSPA8/TUBA1B/YWHAE/TXNIP/CACYBP/UBE2L3	21
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	10/588	94/18367	0.00084716839654967	0.0253839925411176	GAA/GANAB/NAGLU/HEXA/GUSB/MANBA/MAN1A2/FUCA1/NEU1/AGL	10
GO:0098632	cell-cell adhesion mediator activity	7/588	49/18367	0.000888702607628071	0.0253839925411176	BSG/DSG2/JAM3/DSC2/DSP/TRIM29/CNN3	7
GO:0008201	heparin binding	14/588	166/18367	0.00092585938442521	0.0253839925411176	FBN1/NRP2/CCDC80/APLP2/ADGRG1/APP/SOD3/TGFBR3/LRPAP1/ADAMTS1/PTPRF/SMOC1/BMP7/FSTL1	14
GO:0008514	organic anion transmembrane transporter activity	15/588	185/18367	0.000925956960619384	0.0253839925411176	SLC26A2/SLC3A2/SLC2A1/SLC22A11/SLC38A2/SLC1A5/SLC2A8/SLC52A1/GJA1/SLC38A1/SLC52A2/SLC19A1/SLC16A12/SLC38A9/MFSD10	15
GO:0030414	peptidase inhibitor activity	15/588	187/18367	0.0010330269579265	0.0273752143850522	GAPDH/SPINT1/ITIH5/APLP2/CRIM1/APP/SERPINF1/SPINT2/SERPINH1/ROCK1/GPC3/TIMP3/SERPINB9/SERPINB1/TFPI2	15
GO:0016860	intramolecular oxidoreductase activity	7/588	51/18367	0.00113361134449432	0.0278502116663815	P4HB/PDIA3/PDIA4/PTGES2/TPI1/MIF/PTGES3	7
GO:0008022	protein C-terminus binding	15/588	189/18367	0.00115036490739772	0.0278502116663815	FBLN1/BCAM/PRRC2C/DST/CENPF/POLR2A/SIAH1/NIPBL/RABAC1/VAMP2/ID1/NCL/PCNA/DYNLT1/YWHAQ	15
GO:0044325	transmembrane transporter binding	12/588	133/18367	0.00117673854048376	0.0278502116663815	AKAP9/TCAF1/DIAPH1/CALM1/VAMP2/CAV1/CALM2/VDAC1/YWHAE/YWHAH/PHPT1/YWHAQ	12
GO:0015175	neutral amino acid transmembrane transporter activity	6/588	38/18367	0.00121030097819075	0.0278502116663815	SLC3A2/SLC38A2/SLC1A5/SLC43A2/SLC38A1/SLC38A9	6
GO:0005539	glycosaminoglycan binding	17/588	230/18367	0.00122610994757654	0.0278502116663815	FBN1/NRP2/CCDC80/APLP2/ADGRG1/APP/SOD3/TGFBR3/LRPAP1/EXTL2/ADAMTS1/PTPRF/SMOC1/GNS/PPIA/BMP7/FSTL1	17
GO:0005201	extracellular matrix structural constituent	14/588	172/18367	0.00130490325920956	0.0288166136408777	FBN1/FBN2/COL14A1/LAMA5/COL4A2/LAMB1/VWA1/FBLN1/LAMC1/EFEMP1/LTBP1/TINAGL1/FRAS1/TFPI2	14
GO:0044389	ubiquitin-like protein ligase binding	21/588	316/18367	0.00135616735980701	0.0291392716499074	JUN/EGFR/HSPA5/RPL23/HSPA1A/ERBB3/RTN4/UBA52/POLR2A/TPI1/PSMD1/TRIOBP/ACTG1/HM13/NFKBIA/HSPA8/TUBA1B/YWHAE/TXNIP/CACYBP/UBE2L3	21
GO:0051015	actin filament binding	16/588	217/18367	0.00172913615867291	0.0350529265447022	EGFR/MACF1/IQGAP2/UTRN/SYNE2/IQGAP1/MYH10/SPTAN1/SPTBN1/FERMT1/SLC6A4/CFL1/TRIOBP/TPM4/TPM3/CTNNAL1	16
GO:0016853	isomerase activity	13/588	158/18367	0.00173971244747228	0.0350529265447022	P4HB/NKTR/PDIA3/ISYNA1/PPIA/PDIA4/PTGES2/TPI1/MIF/DEGS1/CYP2J2/PPIG/PTGES3	13
GO:0001968	fibronectin binding	5/588	28/18367	0.0017636692601108	0.0350529265447022	FBLN1/CCDC80/CTSL/ITGAV/ITGB1	5
GO:0045182	translation regulator activity	12/588	140/18367	0.00182840148902056	0.0354531508236914	EEF1A1/EIF3A/PURA/EEF1B2/TUFM/EIF4G1/EIF2AK4/EIF2S2/EIF3H/TYMS/CIRBP/EIF4B	12
GO:0048029	monosaccharide binding	8/588	71/18367	0.00190009701640258	0.0359661220961918	LMAN1/ALDOA/BSG/MANBA/SLC2A8/LMAN2/PYGL/UGP2	8
GO:0004866	endopeptidase inhibitor activity	14/588	180/18367	0.00200477320213563	0.0370649929232053	GAPDH/SPINT1/ITIH5/APLP2/CRIM1/APP/SERPINF1/SPINT2/SERPINH1/ROCK1/TIMP3/SERPINB9/SERPINB1/TFPI2	14
GO:0140297	DNA-binding transcription factor binding	24/588	394/18367	0.00207455373414441	0.0374834140601092	JUN/FOS/JUND/TLE4/ISL1/DDIT3/PURA/TACC2/TBX3/NPM1/CITED2/TCF7L2/CENPF/NSD1/HMGN3/FUS/PTMA/NCOA3/NFKBIA/HMGB1/YWHAH/PCNA/GMNN/ANXA4	24
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	7/588	57/18367	0.00219536674938134	0.0387848125724037	P4HB/PDIA3/PCYOX1/PDIA4/GSTO1/MSRB2/TXN	7
GO:0090079	translation regulator activity, nucleic acid binding	10/588	108/18367	0.00243895891455843	0.0421515725450858	EEF1A1/EIF3A/PURA/EEF1B2/TUFM/EIF4G1/EIF2S2/EIF3H/TYMS/EIF4B	10
GO:0047485	protein N-terminus binding	10/588	110/18367	0.00279132792834025	0.0466688586479796	RPS21/HSPA1A/CALM1/NPM1/NIPBL/NCOA3/SRRM2/ID1/CALM2/YWHAQ	10
GO:0090482	vitamin transmembrane transporter activity	5/588	31/18367	0.00281774240893462	0.0466688586479796	SLC2A1/SLC2A8/SLC52A1/SLC52A2/SLC19A1	5
GO:0030246	carbohydrate binding	18/588	271/18367	0.00291759617491058	0.0473365093684471	GAA/GANAB/LMAN1/ALDOA/BSG/GUSB/MANBA/SLC2A8/CRYBG3/GALNT11/OS9/MLEC/CHID1/AGL/LMAN2/CANX/PYGL/UGP2	18
GO:0008330	protein tyrosine/threonine phosphatase activity	3/588	10/18367	0.00331050377352332	0.0511792496024113	DUSP1/DUSP6/DUSP9	3
GO:0050786	RAGE receptor binding	3/588	10/18367	0.00331050377352332	0.0511792496024113	S100A9/HMGB1/HMGB2	3
GO:0019211	phosphatase activator activity	4/588	20/18367	0.00334757355889986	0.0511792496024113	B3GAT3/PPP1R15A/CALM1/CALM2	4
GO:0008200	ion channel inhibitor activity	5/588	33/18367	0.00373460825829641	0.0560191238744462	CALM1/CAV1/RASA1/CALM2/PHPT1	5
GO:0061135	endopeptidase regulator activity	14/588	194/18367	0.00396562409392929	0.0583827991606257	GAPDH/SPINT1/ITIH5/APLP2/CRIM1/APP/SERPINF1/SPINT2/SERPINH1/ROCK1/TIMP3/SERPINB9/SERPINB1/TFPI2	14
GO:0016248	channel inhibitor activity	5/588	34/18367	0.00426522453497356	0.0609191844407952	CALM1/CAV1/RASA1/CALM2/PHPT1	5
GO:0005536	glucose binding	3/588	11/18367	0.00444441848750455	0.0609191844407952	SLC2A8/PYGL/UGP2	3
GO:0019855	calcium channel inhibitor activity	3/588	11/18367	0.00444441848750455	0.0609191844407952	CALM1/CALM2/PHPT1	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/588	11/18367	0.00444441848750455	0.0609191844407952	DSG2/DSC2/DSP	3
GO:0005537	mannose binding	4/588	22/18367	0.00480478758349551	0.0647424767606598	LMAN1/BSG/MANBA/LMAN2	4
GO:0099106	ion channel regulator activity	11/588	139/18367	0.00513314598569483	0.0680141843104565	AKAP9/CALM1/CAV1/PRSS8/FXYD3/RASA1/CALM2/PRKCZ/YWHAE/YWHAH/PHPT1	11
GO:0008135	translation factor activity, RNA binding	8/588	84/18367	0.00542953919450931	0.0703181256888525	EEF1A1/EIF3A/EEF1B2/TUFM/EIF4G1/EIF2S2/EIF3H/EIF4B	8
GO:0042162	telomeric DNA binding	5/588	36/18367	0.00548392929900485	0.0703181256888525	HNRNPA1/PURA/HNRNPD/HNRNPA2B1/NCL	5
GO:0017134	fibroblast growth factor binding	4/588	23/18367	0.00567126229326847	0.0707690186995574	GLG1/ITGAV/TGFBR3/GPC1	4
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	3/588	12/18367	0.00578614618298268	0.0707690186995574	BRD4/CDK6/CDK1	3
GO:0045295	gamma-catenin binding	3/588	12/18367	0.00578614618298268	0.0707690186995574	CDH1/DSC3/TCF7L2	3
GO:0051020	GTPase binding	18/588	291/18367	0.00610001052395769	0.0734773994931267	GOLGA4/IQGAP2/IQGAP1/MYCBP2/ENO1/SPTBN1/ATP6AP1/YBX1/DIAPH1/TRIP11/ROCK1/GCC2/PKN2/CAV1/TRIOBP/PFN1/RASA1/RANBP1	18
GO:0016798	hydrolase activity, acting on glycosyl bonds	11/588	144/18367	0.00666635536492284	0.0791007838076665	GAA/GANAB/NAGLU/HEXA/GUSB/MANBA/MAN1A2/FUCA1/NEU1/AGL/PCNA	11
GO:0016247	channel regulator activity	11/588	145/18367	0.00701203170629421	0.0819789000956455	AKAP9/CALM1/CAV1/PRSS8/FXYD3/RASA1/CALM2/PRKCZ/YWHAE/YWHAH/PHPT1	11
GO:0005542	folic acid binding	3/588	13/18367	0.00734490408973154	0.08279762022172	FOLR1/SLC19A1/TYMS	3
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	3/588	13/18367	0.00734490408973154	0.08279762022172	DUSP1/DUSP6/DUSP9	3
GO:0051087	chaperone binding	9/588	107/18367	0.00739450444747437	0.08279762022172	LRP2/GRN/HSPA5/ERP29/CTSC/DNAJB1/PTGES3/HSPA8/DNAJC9	9
GO:0035035	histone acetyltransferase binding	4/588	25/18367	0.00770342353181615	0.08505863483047	EGR1/GLI3/CITED2/PCNA	4
GO:0003712	transcription coregulator activity	26/588	489/18367	0.00828616438421961	0.0902397354171862	HSPA1A/TLE4/SF1/N4BP2L2/CCAR1/BTG1/TRIP11/MAGED1/KDM5A/NPM1/CITED2/KMT2C/BRD4/NSD1/RSF1/FUS/ARID5B/NCOA3/DNAJB1/TFAP2A/SIAH2/VGLL1/HMGB1/HMGB2/GMNN/UBE2L3	26
GO:0031072	heat shock protein binding	10/588	129/18367	0.00856678035165672	0.0913997649256441	HSPA5/HSPA1A/DNAJB14/TPR/DNAJB1/LMAN2/PTGES3/HSPA8/DNAJC9/DNAJC8	10
GO:0044183	protein folding chaperone	5/588	40/18367	0.00862261933260794	0.0913997649256441	HSPA5/HSPA1A/CCDC47/DNAJB1/HSPA8	5
GO:0015926	glucosidase activity	3/588	14/18367	0.00912835679355268	0.0942473201412257	GAA/GANAB/AGL	3
GO:0044548	S100 protein binding	3/588	14/18367	0.00912835679355268	0.0942473201412257	AHNAK/IQGAP1/CACYBP	3
GO:0004190	aspartic-type endopeptidase activity	4/588	27/18367	0.0101630854981535	0.100995662137901	CTSD/NCSTN/SPPL2A/HM13	4
GO:0023026	MHC class II protein complex binding	4/588	27/18367	0.0101630854981535	0.100995662137901	CD81/PKM/HSPA8/YWHAE	4
GO:0048027	mRNA 5'-UTR binding	4/588	27/18367	0.0101630854981535	0.100995662137901	RPS3A/RPS13/MYH10/NCL	4
GO:0008307	structural constituent of muscle	5/588	42/18367	0.0105816903414973	0.101913006438764	DAG1/KRT19/PLEC/ASPH/TPM4	5
GO:0015036	disulfide oxidoreductase activity	5/588	42/18367	0.0105816903414973	0.101913006438764	P4HB/PDIA3/PDIA4/GSTO1/TXN	5
GO:0016829	lyase activity	13/588	196/18367	0.0106399742571288	0.101913006438764	MGST3/ALDOA/ENO1/GLDC/APMAP/ILVBL/HACD3/PTGES2/TPI1/PISD/ECHDC2/HADHA/HMGB1	13
GO:0005041	low-density lipoprotein particle receptor activity	3/588	15/18367	0.0111427296798243	0.10421729524071	LRP2/LRP1/LRP10	3
GO:0050998	nitric-oxide synthase binding	3/588	15/18367	0.0111427296798243	0.10421729524071	CALM1/SLC6A4/CAV1	3
GO:0070001	aspartic-type peptidase activity	4/588	28/18367	0.011562988204494	0.106890414215962	CTSD/NCSTN/SPPL2A/HM13	4
GO:0015179	L-amino acid transmembrane transporter activity	6/588	61/18367	0.0131371933170644	0.120046766518002	SLC3A2/SLC38A2/SLC1A5/SLC43A2/SLC38A1/SLC38A9	6
GO:0046966	thyroid hormone receptor binding	4/588	30/18367	0.0147201421107903	0.132983102023617	NSD1/HMGN3/FUS/NCOA3	4
GO:0000400	four-way junction DNA binding	3/588	17/18367	0.0158825777164818	0.141002070211081	HMGB1/HMGB3/HMGB2	3
GO:0046943	carboxylic acid transmembrane transporter activity	11/588	163/18367	0.015962498514462	0.141002070211081	SLC26A2/SLC3A2/SLC38A2/SLC38A10/SLC1A5/SLC43A2/SLC38A1/SLC19A1/SLC27A2/SLC16A12/SLC38A9	11
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	17/588	299/18367	0.0163949097759945	0.143230255735337	JUN/FOS/JUND/ISL1/TACC2/TBX3/NPM1/CITED2/TCF7L2/NSD1/HMGN3/FUS/NCOA3/NFKBIA/YWHAH/PCNA/ANXA4	17
GO:0005342	organic acid transmembrane transporter activity	11/588	164/18367	0.0166351363404572	0.143680414198542	SLC26A2/SLC3A2/SLC38A2/SLC38A10/SLC1A5/SLC43A2/SLC38A1/SLC19A1/SLC27A2/SLC16A12/SLC38A9	11
GO:0019199	transmembrane receptor protein kinase activity	10/588	143/18367	0.0168078975100182	0.143680414198542	EGFR/NRP2/EFEMP1/CRIM1/LTBP1/TGFBR3/MET/EPHB4/ERBB3/IGF1R	10
GO:0005200	structural constituent of cytoskeleton	8/588	103/18367	0.0175585116419389	0.144873235608105	KRT19/PLEC/SPTAN1/SPTBN1/ACTG1/DSP/TUBA1B/TUBA1C	8
GO:0016922	nuclear receptor binding	10/588	144/18367	0.0175647290133835	0.144873235608105	JUND/ISL1/TACC2/TCF7L2/NSD1/HMGN3/FUS/NCOA3/YWHAH/PCNA	10
GO:0015171	amino acid transmembrane transporter activity	7/588	84/18367	0.018040256705161	0.144873235608105	SLC3A2/SLC38A2/SLC38A10/SLC1A5/SLC43A2/SLC38A1/SLC38A9	7
GO:0030165	PDZ domain binding	7/588	84/18367	0.018040256705161	0.144873235608105	ATP2B1/CRIM1/TGFBR3/CADM1/GJA1/ADRB1/GNG5	7
GO:0015026	coreceptor activity	5/588	48/18367	0.0182302761627016	0.144873235608105	LRP1/ITGAV/TGFBR3/ITGB1/LRP5	5
GO:0008301	DNA binding, bending	3/588	18/18367	0.0186142409085102	0.144873235608105	HMGB1/HMGB3/HMGB2	3
GO:0030228	lipoprotein particle receptor activity	3/588	18/18367	0.0186142409085102	0.144873235608105	LRP2/LRP1/LRP10	3
GO:0033549	MAP kinase phosphatase activity	3/588	18/18367	0.0186142409085102	0.144873235608105	DUSP1/DUSP6/DUSP9	3
GO:0140597	protein carrier activity	3/588	18/18367	0.0186142409085102	0.144873235608105	EMC1/EMC10/HSPA8	3
GO:0033218	amide binding	21/588	400/18367	0.0187697399592891	0.144873235608105	LRP1/LRPAP1/PSAP/ENPEP/DHCR24/FOLR1/NKTR/CTSV/IGF1R/SLC19A1/SLC40A1/PPIA/PRLR/PTGES2/ITM2B/PPIG/ACADVL/NFKBIA/TYMS/HADHA/VDAC1	21
GO:0043539	protein serine/threonine kinase activator activity	5/588	49/18367	0.0197838563874813	0.151232363731227	IQGAP1/CALM1/CALM2/CKS1B/IGF2	5
GO:0097110	scaffold protein binding	6/588	67/18367	0.0201366936716958	0.152081586020169	PSAP/IL6ST/DSP/KRT8/DYNLL1/YWHAE	6
GO:0016209	antioxidant activity	7/588	86/18367	0.0202775448026892	0.152081586020169	MGST3/SOD3/GSTO1/TXN/GPX3/S100A9/GPX1	7
GO:0003746	translation elongation factor activity	3/588	19/18367	0.0215893852248813	0.159960188470468	EEF1A1/EEF1B2/TUFM	3
GO:0043021	ribonucleoprotein complex binding	10/588	149/18367	0.0217304406978749	0.159960188470468	NEAT1/HSPA5/RPN2/NPM1/NEMF/CCDC47/SNRPD2/EIF4B/CSNK2B/SERBP1	10
GO:0003713	transcription coactivator activity	15/588	262/18367	0.021987334065194	0.160366335613112	CCAR1/TRIP11/MAGED1/KDM5A/NPM1/CITED2/KMT2C/BRD4/FUS/ARID5B/NCOA3/VGLL1/HMGB1/HMGB2/UBE2L3	15
GO:0045505	dynein intermediate chain binding	4/588	34/18367	0.0225430169422024	0.162590139897423	DYNC1H1/DYNLL1/DYNLRB1/DYNLT1	4
GO:0048306	calcium-dependent protein binding	7/588	88/18367	0.0227012648158667	0.162590139897423	SLC9A1/CALM1/VAMP2/S100A9/S100P/CALM2/ANXA4	7
GO:0003743	translation initiation factor activity	5/588	51/18367	0.0231452860860183	0.164290200342719	EIF3A/EIF4G1/EIF2S2/EIF3H/EIF4B	5
GO:0019888	protein phosphatase regulator activity	7/588	89/18367	0.0239851115329586	0.164356501047861	BOD1L1/PPP1R10/B3GAT3/PPP1R15A/CALM1/PHACTR2/CALM2	7
GO:0004857	enzyme inhibitor activity	6/588	70/18367	0.024439192911409	0.164356501047861	RPS20/RPL23/ANXA5/DYNLL1/TXNIP/ANXA4	6
GO:0015103	inorganic anion transmembrane transporter activity	10/588	152/18367	0.0245506806726034	0.164356501047861	SLC26A2/CLDN4/SLC22A11/GABRE/SLC12A9/SLC13A4/SLC6A4/FXYD3/VDAC1/CLIC3	10
GO:0003756	protein disulfide isomerase activity	3/588	20/18367	0.0248085284600544	0.164356501047861	P4HB/PDIA3/PDIA4	3
GO:0016018	cyclosporin A binding	3/588	20/18367	0.0248085284600544	0.164356501047861	NKTR/PPIA/PPIG	3
GO:0016500	protein-hormone receptor activity	3/588	20/18367	0.0248085284600544	0.164356501047861	LGR5/LGR4/IGF1R	3
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	3/588	20/18367	0.0248085284600544	0.164356501047861	P4HB/PDIA3/PDIA4	3
GO:0030506	ankyrin binding	3/588	20/18367	0.0248085284600544	0.164356501047861	CDH1/PLEC/SPTBN1	3
GO:0000217	DNA secondary structure binding	4/588	36/18367	0.0272441119212762	0.17753335227389	HNRNPD/HMGB1/HMGB3/HMGB2	4
GO:0023023	MHC protein complex binding	4/588	36/18367	0.0272441119212762	0.17753335227389	CD81/PKM/HSPA8/YWHAE	4
GO:0005385	zinc ion transmembrane transporter activity	3/588	21/18367	0.0282713060345381	0.18125555078595	SLC39A10/SLC39A7/SLC39A1	3
GO:0140416	transcription regulator inhibitor activity	3/588	21/18367	0.0282713060345381	0.18125555078595	DDIT3/PURA/ID1	3
GO:0005516	calmodulin binding	12/588	201/18367	0.0287204249964348	0.181992470290858	ATP2B1/EGFR/IQGAP2/KCNN4/IQGAP1/MYH10/SPTAN1/SPTBN1/SLC9A1/VAMP2/ASPM/CNN3	12
GO:0015459	potassium channel regulator activity	5/588	54/18367	0.0288440896310039	0.181992470290858	AKAP9/CAV1/RASA1/PRKCZ/YWHAE	5
GO:0002020	protease binding	9/588	135/18367	0.0296793313087087	0.183636862886226	ADAMTSL4/LRP1/ITGAV/ITGB1/PSAP/DPP4/OS9/TIMP3/SERPINB9	9
GO:0015035	protein-disulfide reductase activity	4/588	37/18367	0.0297976796381423	0.183636862886226	P4HB/PDIA3/PDIA4/TXN	4
GO:0046915	transition metal ion transmembrane transporter activity	4/588	37/18367	0.0297976796381423	0.183636862886226	SLC39A10/SLC40A1/SLC39A7/SLC39A1	4
GO:0017022	myosin binding	6/588	74/18367	0.0310737887780771	0.186921719875168	VAMP2/FUS/TRIOBP/MYL12B/RHOA/RAB11A	6
GO:0019887	protein kinase regulator activity	12/588	204/18367	0.0316871938697685	0.186921719875168	CCNL1/IQGAP1/ERBB3/CALM1/NPM1/CDKN1C/CCND3/CALM2/CKS1B/HMGB1/IGF2/CSNK2B	12
GO:0004602	glutathione peroxidase activity	3/588	22/18367	0.0319765457899659	0.186921719875168	MGST3/GPX3/GPX1	3
GO:0015296	anion:cation symporter activity	3/588	22/18367	0.0319765457899659	0.186921719875168	SLC12A9/SLC13A4/SLC6A4	3
GO:0055106	ubiquitin-protein transferase regulator activity	3/588	22/18367	0.0319765457899659	0.186921719875168	RPS20/RPL23/UBE2L3	3
GO:0070182	DNA polymerase binding	3/588	22/18367	0.0319765457899659	0.186921719875168	PTGES3/HMGB1/PCNA	3
GO:0072349	modified amino acid transmembrane transporter activity	3/588	22/18367	0.0319765457899659	0.186921719875168	GJA1/SLC19A1/SLC16A12	3
GO:0019955	cytokine binding	9/588	139/18367	0.034858984095646	0.202283885810501	CSF3R/NRP2/ITGAV/LTBP1/TGFBR3/ITGB1/PRLR/IL6ST/HMGB1	9
GO:0005158	insulin receptor binding	3/588	23/18367	0.0359223383144705	0.206943905507276	IGF1R/PHIP/IGF2	3
GO:0038024	cargo receptor activity	6/588	77/18367	0.0367540837316182	0.21021220551537	LRP2/LRP1/LGALS3BP/FOLR1/TFRC/LRP10	6
GO:0004177	aminopeptidase activity	4/588	40/18367	0.0382818268083816	0.214381943906326	ENPEP/MMP15/CTSV/DPP4	4
GO:0003714	transcription corepressor activity	11/588	187/18367	0.0386125800191364	0.214381943906326	HSPA1A/TLE4/SF1/N4BP2L2/CCAR1/CITED2/NSD1/DNAJB1/TFAP2A/SIAH2/GMNN	11
GO:0004300	enoyl-CoA hydratase activity	2/588	10/18367	0.03883144644341	0.214381943906326	ECHDC2/HADHA	2
GO:0008239	dipeptidyl-peptidase activity	2/588	10/18367	0.03883144644341	0.214381943906326	CTSC/DPP4	2
GO:0098505	G-rich strand telomeric DNA binding	2/588	10/18367	0.03883144644341	0.214381943906326	HNRNPA1/HNRNPA2B1	2
GO:0031267	small GTPase binding	14/588	259/18367	0.0398189146078163	0.21831749733251	GOLGA4/IQGAP2/IQGAP1/MYCBP2/ATP6AP1/DIAPH1/TRIP11/ROCK1/GCC2/PKN2/CAV1/TRIOBP/PFN1/RANBP1	14
GO:0050431	transforming growth factor beta binding	3/588	24/18367	0.0401061030258633	0.2183859719559	ITGAV/LTBP1/TGFBR3	3
GO:0016859	cis-trans isomerase activity	4/588	41/18367	0.0413860538799016	0.222310221854877	NKTR/PPIA/DEGS1/PPIG	4
GO:0030331	estrogen receptor binding	4/588	41/18367	0.0413860538799016	0.222310221854877	ISL1/NSD1/FUS/PCNA	4
GO:0030295	protein kinase activator activity	7/588	101/18367	0.0434142949006604	0.231640029839094	IQGAP1/ERBB3/CALM1/CALM2/CKS1B/HMGB1/IGF2	7
GO:0051019	mitogen-activated protein kinase binding	3/588	25/18367	0.044524650229597	0.235325105274231	DUSP1/IQGAP1/TPR	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	8/588	124/18367	0.0459173848674359	0.235325105274231	EGFR/NRP2/EFEMP1/CRIM1/MET/EPHB4/ERBB3/IGF1R	8
GO:0000774	adenyl-nucleotide exchange factor activity	2/588	11/18367	0.046473008211389	0.235325105274231	SIL1/PFN1	2
GO:0002162	dystroglycan binding	2/588	11/18367	0.046473008211389	0.235325105274231	DAG1/PLEC	2
GO:0008199	ferric iron binding	2/588	11/18367	0.046473008211389	0.235325105274231	FTH1/RRM2	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/588	11/18367	0.046473008211389	0.235325105274231	P4HB/PCYOX1	2
GO:0022889	serine transmembrane transporter activity	2/588	11/18367	0.046473008211389	0.235325105274231	SLC38A2/SLC1A5	2
GO:0043560	insulin receptor substrate binding	2/588	11/18367	0.046473008211389	0.235325105274231	IGF1R/PRKCZ	2
GO:0008238	exopeptidase activity	7/588	103/18367	0.0474159743420762	0.237460781720443	ENPEP/CTSC/MMP15/CTSA/CTSV/DPP4/TFRC	7
GO:0005246	calcium channel regulator activity	4/588	43/18367	0.048009324668099	0.237460781720443	CALM1/CALM2/YWHAE/PHPT1	4
GO:0016504	peptidase activator activity	4/588	43/18367	0.048009324668099	0.237460781720443	FBLN1/APP/CTSC/CAV1	4
GO:1990841	promoter-specific chromatin binding	5/588	62/18367	0.0480895419584796	0.237460781720443	EGR1/ISL1/POLR2A/NIPBL/E2F4	5
GO:0030371	translation repressor activity	3/588	26/18367	0.049174239358414	0.241318026481106	PURA/TYMS/CIRBP	3
GO:0009055	electron transfer activity	8/588	126/18367	0.0496274586194558	0.242048034370966	COX6A1/GLDC/POR/ASPH/NDUFB9/DEGS1/UQCRH/CYBA	8
GO:0019902	phosphatase binding	11/588	196/18367	0.0511141987249372	0.247779195038567	EGFR/HSP90B1/KCNN4/BOD1L1/MET/IQGAP1/CTSC/SLC9A1/PPP1R15A/HMGCR/CARHSP1	11
GO:0019903	protein phosphatase binding	9/588	150/18367	0.0522162022003704	0.25158715605633	EGFR/HSP90B1/KCNN4/BOD1L1/MET/IQGAP1/SLC9A1/PPP1R15A/HMGCR	9
GO:0045499	chemorepellent activity	3/588	27/18367	0.0540506335909465	0.252414259247505	SEMA6A/SEMA6D/DPP4	3
GO:0051959	dynein light intermediate chain binding	3/588	27/18367	0.0540506335909465	0.252414259247505	DYNC1H1/HOOK2/DYNLL1	3
GO:0005024	transforming growth factor beta-activated receptor activity	2/588	12/18367	0.0546103806170702	0.252414259247505	LTBP1/TGFBR3	2
GO:0005095	GTPase inhibitor activity	2/588	12/18367	0.0546103806170702	0.252414259247505	IQGAP2/IQGAP1	2
GO:0017154	semaphorin receptor activity	2/588	12/18367	0.0546103806170702	0.252414259247505	NRP2/MET	2
GO:0017166	vinculin binding	2/588	12/18367	0.0546103806170702	0.252414259247505	DAG1/UTRN	2
GO:0043047	single-stranded telomeric DNA binding	2/588	12/18367	0.0546103806170702	0.252414259247505	HNRNPA1/HNRNPA2B1	2
GO:0008013	beta-catenin binding	6/588	85/18367	0.0549939161636116	0.252717707225845	CDH1/KANK1/GJA1/GLI3/DLG5/TCF7L2	6
GO:0019208	phosphatase regulator activity	7/588	107/18367	0.0561053199961469	0.254878453696782	BOD1L1/PPP1R10/B3GAT3/PPP1R15A/CALM1/PHACTR2/CALM2	7
GO:0019209	kinase activator activity	7/588	107/18367	0.0561053199961469	0.254878453696782	IQGAP1/ERBB3/CALM1/CALM2/CKS1B/HMGB1/IGF2	7
GO:0070325	lipoprotein particle receptor binding	3/588	28/18367	0.0591491510373208	0.267179403833352	LRP1/HSP90B1/LRPAP1	3
GO:0035254	glutamate receptor binding	4/588	47/18367	0.0629021365387204	0.275534658997024	CALM1/FUS/CANX/MYL12A	4
GO:0004859	phospholipase inhibitor activity	2/588	13/18367	0.0632041036220409	0.275534658997024	ANXA5/ANXA4	2
GO:0008179	adenylate cyclase binding	2/588	13/18367	0.0632041036220409	0.275534658997024	CALM1/CALM2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/588	13/18367	0.0632041036220409	0.275534658997024	SLC26A2/SLC13A4	2
GO:0031432	titin binding	2/588	13/18367	0.0632041036220409	0.275534658997024	CALM1/CALM2	2
GO:0060590	ATPase regulator activity	2/588	13/18367	0.0632041036220409	0.275534658997024	SIL1/PFN1	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	3/588	29/18367	0.0644647126710019	0.275534658997024	CDK6/CCND3/CDK1	3
GO:0051059	NF-kappaB binding	3/588	29/18367	0.0644647126710019	0.275534658997024	NPM1/NFKBIA/ANXA4	3
GO:0051787	misfolded protein binding	3/588	29/18367	0.0644647126710019	0.275534658997024	HSPA5/HSPA1A/HSPA8	3
GO:0097472	cyclin-dependent protein kinase activity	3/588	29/18367	0.0644647126710019	0.275534658997024	CDK6/CCND3/CDK1	3
GO:0005518	collagen binding	5/588	69/18367	0.0699166786683798	0.294410319080768	COL14A1/CTSL/ADGRG1/ITGB1/SERPINH1	5
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/588	30/18367	0.0699918871776921	0.294410319080768	SLC26A2/SLC1A5/SLC19A1	3
GO:0022829	wide pore channel activity	3/588	30/18367	0.0699918871776921	0.294410319080768	GJA5/GJA1/VDAC1	3
GO:0004713	protein tyrosine kinase activity	8/588	136/18367	0.0710488889431666	0.296268607617679	EGFR/NRP2/EFEMP1/CRIM1/MET/EPHB4/ERBB3/IGF1R	8
GO:0015373	anion:sodium symporter activity	2/588	14/18367	0.0722167280934556	0.296268607617679	SLC13A4/SLC6A4	2
GO:0032977	membrane insertase activity	2/588	14/18367	0.0722167280934556	0.296268607617679	EMC1/EMC10	2
GO:0043023	ribosomal large subunit binding	2/588	14/18367	0.0722167280934556	0.296268607617679	NPM1/NEMF	2
GO:0019207	kinase regulator activity	12/588	233/18367	0.0722969935570185	0.296268607617679	CCNL1/IQGAP1/ERBB3/CALM1/NPM1/CDKN1C/CCND3/CALM2/CKS1B/HMGB1/IGF2/CSNK2B	12
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/588	50/18367	0.0754817392550783	0.307733244655319	CCNL1/CDKN1C/CCND3/CKS1B	4
GO:0003924	GTPase activity	16/588	337/18367	0.0764973208115819	0.310282500230651	RHOB/EEF1A1/GNAQ/GNG5/ARL4A/TUFM/GNAI2/RASA1/ARF5/RHOA/TUBA1B/RAN/CDC42/RGS10/RAB11A/TUBA1C	16
GO:0072341	modified amino acid binding	6/588	93/18367	0.0778600427880652	0.314206771657421	FOLR1/SLC19A1/PTGES2/TYMS/HSPA8/HMGB1	6
GO:0010851	cyclase regulator activity	2/588	15/18367	0.0816127278493988	0.319793006661813	CALM1/CALM2	2
GO:0015929	hexosaminidase activity	2/588	15/18367	0.0816127278493988	0.319793006661813	NAGLU/HEXA	2
GO:0071933	Arp2/3 complex binding	2/588	15/18367	0.0816127278493988	0.319793006661813	IQGAP2/WASF2	2
GO:0098847	sequence-specific single stranded DNA binding	2/588	15/18367	0.0816127278493988	0.319793006661813	HNRNPA1/HNRNPA2B1	2
GO:1990825	sequence-specific mRNA binding	2/588	15/18367	0.0816127278493988	0.319793006661813	TYMS/SRSF3	2
GO:0071889	14-3-3 protein binding	3/588	32/18367	0.0816578369211925	0.319793006661813	ZFP36L1/PRKCZ/YWHAQ	3
GO:0070063	RNA polymerase binding	5/588	73/18367	0.0844698848177352	0.329184109951468	PABPN1/PKN2/BRD4/STOM/NCOA3	5
GO:0015291	secondary active transmembrane transporter activity	12/588	240/18367	0.0856243764370387	0.332055508621687	SLC26A2/SLC3A2/SLC22A11/SLC38A2/SLC1A5/SLC12A9/SLC38A1/SLC9A1/SLC19A1/SLC13A4/SLC16A12/SLC6A4	12
GO:0004197	cysteine-type endopeptidase activity	7/588	119/18367	0.087765417278845	0.334700184937717	CTSL/CTSD/GPAA1/CTSC/CTSV/PDIA3/LGMN	7
GO:0019956	chemokine binding	3/588	33/18367	0.0877843517709413	0.334700184937717	ITGAV/ITGB1/HMGB1	3
GO:0003725	double-stranded RNA binding	5/588	74/18367	0.0883391671394495	0.334700184937717	SLC3A2/TFRC/TUBA1B/HMGB1/EIF4B	5
GO:0022853	active ion transmembrane transporter activity	13/588	267/18367	0.0888189497966914	0.334700184937717	ATP2B1/SLC26A2/COX6A1/SLC3A2/SLC22A11/SLC38A2/SLC12A9/SLC38A1/SLC9A1/SLC19A1/SLC13A4/SLC6A4/UQCRH	13
GO:0050661	NADP binding	4/588	53/18367	0.0892246892545949	0.334700184937717	GAPDH/HMGCR/POR/HSD17B1	4
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/588	16/18367	0.091358415259729	0.334700184937717	PURA/TYMS	2
GO:0004698	calcium-dependent protein kinase C activity	2/588	16/18367	0.091358415259729	0.334700184937717	PKN2/PRKCZ	2
GO:0005159	insulin-like growth factor receptor binding	2/588	16/18367	0.091358415259729	0.334700184937717	IGF2/YWHAH	2
GO:0005283	amino acid:sodium symporter activity	2/588	16/18367	0.091358415259729	0.334700184937717	SLC38A2/SLC38A1	2
GO:0015923	mannosidase activity	2/588	16/18367	0.091358415259729	0.334700184937717	MANBA/MAN1A2	2
GO:0016208	AMP binding	2/588	16/18367	0.091358415259729	0.334700184937717	ACSS1/PYGL	2
GO:0070403	NAD+ binding	2/588	16/18367	0.091358415259729	0.334700184937717	HADHA/HPGD	2
GO:0042393	histone binding	12/588	244/18367	0.0938844970208096	0.341588736627101	CTSL/BPTF/ATRX/PHIP/KDM5A/NPM1/KMT2C/BRD4/RSF1/MPHOSPH8/CKS1B/DNAJC9	12
GO:0008376	acetylgalactosaminyltransferase activity	3/588	34/18367	0.0940980293350127	0.341588736627101	CHPF/EXTL2/GALNT11	3
GO:0030674	protein-macromolecule adaptor activity	14/588	296/18367	0.0951433140128732	0.343813339273792	COL14A1/SYNE2/IQGAP1/NCSTN/SLC9A1/DDB1/SERINC1/DLG5/FRMD4A/CUX1/VAMP2/CAV1/AP1S1/HSPA8	14
GO:0015631	tubulin binding	17/588	375/18367	0.0958084448718376	0.344650288113624	GAPDH/DAG1/MACF1/CLIP1/GPAA1/ALDOA/GJA1/DST/KIF5B/CENPF/HOOK2/TPR/S100A9/STMN1/CACYBP/CNN3/RAB11A	17
GO:0004697	protein kinase C activity	2/588	17/18367	0.101421860265495	0.346053128373686	PKN2/PRKCZ	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	2/588	17/18367	0.101421860265495	0.346053128373686	PTPRF/PTPRA	2
GO:0005324	long-chain fatty acid transporter activity	2/588	17/18367	0.101421860265495	0.346053128373686	SLC2A1/SLC27A2	2
GO:0008381	mechanosensitive ion channel activity	2/588	17/18367	0.101421860265495	0.346053128373686	TMC5/TMEM150C	2
GO:0015116	sulfate transmembrane transporter activity	2/588	17/18367	0.101421860265495	0.346053128373686	SLC26A2/SLC13A4	2
GO:0015377	cation:chloride symporter activity	2/588	17/18367	0.101421860265495	0.346053128373686	SLC12A9/SLC6A4	2
GO:0019198	transmembrane receptor protein phosphatase activity	2/588	17/18367	0.101421860265495	0.346053128373686	PTPRF/PTPRA	2
GO:0031489	myosin V binding	2/588	17/18367	0.101421860265495	0.346053128373686	FUS/RAB11A	2
GO:0034185	apolipoprotein binding	2/588	17/18367	0.101421860265495	0.346053128373686	LRP1/CANX	2
GO:0043024	ribosomal small subunit binding	2/588	17/18367	0.101421860265495	0.346053128373686	NPM1/EIF4B	2
GO:0046965	retinoid X receptor binding	2/588	17/18367	0.101421860265495	0.346053128373686	NSD1/FUS	2
GO:0070064	proline-rich region binding	2/588	17/18367	0.101421860265495	0.346053128373686	RABAC1/PFN1	2
GO:0016758	hexosyltransferase activity	10/588	197/18367	0.102014261753445	0.346586914931576	CHPF/RPN2/HEXA/EXTL2/B3GAT3/C1GALT1/GALNT11/MGAT1/AGL/PYGL	10
GO:0051287	NAD binding	4/588	56/18367	0.104076754723412	0.352089446830265	GAPDH/LDHA/HADHA/HPGD	4
GO:0046982	protein heterodimerization activity	15/588	328/18367	0.106607483024368	0.359122665272766	TENM3/P4HB/ITGB1/HEXA/ADRB1/ERBB3/DDIT3/JAM3/CAV1/XBP1/TPM4/RAN/YWHAE/YWHAH/CYBA	15
GO:0043394	proteoglycan binding	3/588	36/18367	0.107260265456101	0.359797092985656	LRP1/CTSL/PTPRF	3
GO:0016835	carbon-oxygen lyase activity	5/588	79/18367	0.109026283140586	0.361287432840574	ENO1/HACD3/TPI1/ECHDC2/HADHA	5
GO:0046332	SMAD binding	5/588	79/18367	0.109026283140586	0.361287432840574	JUN/FOS/TGFBR3/PURA/CITED2	5
GO:0004725	protein tyrosine phosphatase activity	6/588	102/18367	0.109067904253758	0.361287432840574	DUSP1/DUSP6/PTPRF/DUSP9/PTPRA/PGP	6
GO:0031435	mitogen-activated protein kinase kinase kinase binding	2/588	18/18367	0.111772812685118	0.365676485945141	MARVELD3/CDC42	2
GO:0055102	lipase inhibitor activity	2/588	18/18367	0.111772812685118	0.365676485945141	ANXA5/ANXA4	2
GO:0098641	cadherin binding involved in cell-cell adhesion	2/588	18/18367	0.111772812685118	0.365676485945141	TRIM29/CNN3	2
GO:0042826	histone deacetylase binding	7/588	127/18367	0.113503438269076	0.369816530425884	HSPA1A/GLI3/PKN2/NIPBL/HNRNPD/YWHAE/GMNN	7
GO:0042056	chemoattractant activity	3/588	37/18367	0.114095199498862	0.370227280006512	MIF/HMGB1/HMGB2	3
GO:0036002	pre-mRNA binding	4/588	59/18367	0.119973388653769	0.387718877966448	SF1/HNRNPA1/SRSF6/TRA2B	4
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/588	38/18367	0.12109010008305	0.389743439538561	NKTR/PPIA/PPIG	3
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/588	19/18367	0.122382627680441	0.392315278249799	LTBP1/TGFBR3	2
GO:0043621	protein self-association	4/588	61/18367	0.131115748622167	0.4186225709021	SLC2A1/PLEC/CTSC/VAMP2	4
GO:0016675	oxidoreductase activity, acting on a heme group of donors	2/588	20/18367	0.133224194260483	0.420290612845572	COX6A1/POR	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/588	20/18367	0.133224194260483	0.420290612845572	GNAQ/GNAI2	2
GO:0097001	ceramide binding	2/588	20/18367	0.133224194260483	0.420290612845572	PSAP/VDAC1	2
GO:0003925	G protein activity	3/588	40/18367	0.135531689269486	0.424203515626936	RHOA/CDC42/RAB11A	3
GO:0017080	sodium channel regulator activity	3/588	40/18367	0.135531689269486	0.424203515626936	PRSS8/FXYD3/YWHAH	3
GO:0060090	molecular adaptor activity	16/588	369/18367	0.136535549917598	0.425669655625452	COL14A1/AKAP9/SYNE2/IQGAP1/NCSTN/SLC9A1/DDB1/SERINC1/DLG5/FRMD4A/EIF4G1/CUX1/VAMP2/CAV1/AP1S1/HSPA8	16
GO:0008047	enzyme activator activity	6/588	110/18367	0.141401807194334	0.437782766653365	PSAP/MMP15/CTSA/DDOST/CALM1/CALM2	6
GO:0042562	hormone binding	5/588	86/18367	0.141522227710585	0.437782766653365	LRP2/EGFR/IGF1R/SLC40A1/PRLR	5
GO:0005243	gap junction channel activity	2/588	21/18367	0.14427186670532	0.439448789389767	GJA5/GJA1	2
GO:0051010	microtubule plus-end binding	2/588	21/18367	0.14427186670532	0.439448789389767	CLIP1/DST	2
GO:0070577	lysine-acetylated histone binding	2/588	21/18367	0.14427186670532	0.439448789389767	PHIP/BRD4	2
GO:0140033	acetylation-dependent protein binding	2/588	21/18367	0.14427186670532	0.439448789389767	PHIP/BRD4	2
GO:0003727	single-stranded RNA binding	5/588	87/18367	0.146476382705016	0.442770814640637	HNRNPA1/HNRNPDL/HNRNPC/HMGB1/EIF4B	5
GO:0005253	anion channel activity	5/588	87/18367	0.146476382705016	0.442770814640637	CLDN4/GABRE/FXYD3/VDAC1/CLIC3	5
GO:0016836	hydro-lyase activity	4/588	64/18367	0.148588056487791	0.44745267010528	ENO1/HACD3/ECHDC2/HADHA	4
GO:0042277	peptide binding	14/588	321/18367	0.151085863582479	0.453257590747437	LRP1/LRPAP1/ENPEP/DHCR24/NKTR/CTSV/IGF1R/SLC40A1/PPIA/PRLR/PTGES2/ITM2B/PPIG/NFKBIA	14
GO:0000062	fatty-acyl-CoA binding	2/588	22/18367	0.155501398796855	0.45786522979074	ACADVL/HADHA	2
GO:0005355	glucose transmembrane transporter activity	2/588	22/18367	0.155501398796855	0.45786522979074	SLC2A1/SLC2A8	2
GO:0005416	amino acid:cation symporter activity	2/588	22/18367	0.155501398796855	0.45786522979074	SLC38A2/SLC38A1	2
GO:0015149	hexose transmembrane transporter activity	2/588	22/18367	0.155501398796855	0.45786522979074	SLC2A1/SLC2A8	2
GO:0017075	syntaxin-1 binding	2/588	22/18367	0.155501398796855	0.45786522979074	SLC6A4/VAMP2	2
GO:0051117	ATPase binding	5/588	89/18367	0.156602385386193	0.459405521704882	EGFR/NCSTN/CAV1/DNAJB1/FBL	5
GO:0030544	Hsp70 protein binding	3/588	43/18367	0.158217457465378	0.462437053988881	DNAJB14/DNAJB1/DNAJC8	3
GO:0043022	ribosome binding	4/588	66/18367	0.16070631665922	0.467990922139487	HSPA5/RPN2/CCDC47/SERBP1	4
GO:0008375	acetylglucosaminyltransferase activity	3/588	44/18367	0.166024020899543	0.473848054265389	HEXA/EXTL2/MGAT1	3
GO:0009931	calcium-dependent protein serine/threonine kinase activity	2/588	23/18367	0.166889880747558	0.473848054265389	PKN2/PRKCZ	2
GO:0030215	semaphorin receptor binding	2/588	23/18367	0.166889880747558	0.473848054265389	SEMA6A/SEMA6D	2
GO:0050750	low-density lipoprotein particle receptor binding	2/588	23/18367	0.166889880747558	0.473848054265389	HSP90B1/LRPAP1	2
GO:0070412	R-SMAD binding	2/588	23/18367	0.166889880747558	0.473848054265389	JUN/FOS	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/588	23/18367	0.166889880747558	0.473848054265389	C1GALT1/MGAT1	2
GO:1901567	fatty acid derivative binding	2/588	23/18367	0.166889880747558	0.473848054265389	ACADVL/HADHA	2
GO:0051213	dioxygenase activity	5/588	92/18367	0.172309235975798	0.487494101782061	P4HB/RSBN1L/POR/KDM5A/ASPH	5
GO:0003684	damaged DNA binding	4/588	68/18367	0.17317097616454	0.48819477322982	DDB1/HMGB1/PCNA/HMGB2	4
GO:0001965	G-protein alpha-subunit binding	2/588	24/18367	0.178415678722258	0.494217646634826	NUCB1/RGS10	2
GO:0010857	calcium-dependent protein kinase activity	2/588	24/18367	0.178415678722258	0.494217646634826	PKN2/PRKCZ	2
GO:0015145	monosaccharide transmembrane transporter activity	2/588	24/18367	0.178415678722258	0.494217646634826	SLC2A1/SLC2A8	2
GO:0043274	phospholipase binding	2/588	24/18367	0.178415678722258	0.494217646634826	PRKCZ/SRSF3	2
GO:0070840	dynein complex binding	2/588	24/18367	0.178415678722258	0.494217646634826	CENPF/TPR	2
GO:0015293	symporter activity	7/588	144/18367	0.179517181959191	0.495542221033184	SLC38A2/SLC1A5/SLC12A9/SLC38A1/SLC13A4/SLC16A12/SLC6A4	7
GO:0004864	protein phosphatase inhibitor activity	3/588	46/18367	0.181962108473787	0.500553204971145	BOD1L1/PPP1R10/PHACTR2	3
GO:0005112	Notch binding	2/588	25/18367	0.190058376852055	0.513991387405552	AAK1/GALNT11	2
GO:0034237	protein kinase A regulatory subunit binding	2/588	25/18367	0.190058376852055	0.513991387405552	AKAP9/WASF2	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/588	25/18367	0.190058376852055	0.513991387405552	ZFP36L1/HNRNPD	2
GO:0120227	acyl-CoA binding	2/588	25/18367	0.190058376852055	0.513991387405552	ACADVL/HADHA	2
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/588	47/18367	0.190079833832997	0.513991387405552	DUSP1/DUSP6/DUSP9	3
GO:0004721	phosphoprotein phosphatase activity	8/588	174/18367	0.195452242787046	0.5267272305617	DUSP1/DUSP6/PTPRF/DUSP9/PTPRA/CTDSPL/PGP/PHPT1	8
GO:0003730	mRNA 3'-UTR binding	9/588	201/18367	0.196693072274163	0.52828037992554	ZFP36L1/PUM1/FUS/HNRNPC/HNRNPD/CIRBP/HNRNPA2B1/CARHSP1/SERBP1	9
GO:0000049	tRNA binding	4/588	72/18367	0.199035021446266	0.529042076572987	EEF1A1/NEMF/EIF2AK4/IARS2	4
GO:0042974	retinoic acid receptor binding	2/588	26/18367	0.201798721643191	0.529042076572987	NSD1/FUS	2
GO:0097602	cullin family protein binding	2/588	26/18367	0.201798721643191	0.529042076572987	DDB1/ANAPC11	2
GO:0003697	single-stranded DNA binding	6/588	123/18367	0.201949003095285	0.529042076572987	HNRNPA1/YBX1/PURA/HNRNPA2B1/HMGB1/HMGB2	6
GO:0031406	carboxylic acid binding	8/588	176/18367	0.203670447461941	0.529042076572987	PSAP/GLDC/FOLR1/SLC19A1/NR2F2/S100A9/TYMS/PYGL	8
GO:0015370	solute:sodium symporter activity	4/588	73/18367	0.205676478642123	0.529042076572987	SLC38A2/SLC38A1/SLC13A4/SLC6A4	4
GO:0033293	monocarboxylic acid binding	4/588	73/18367	0.205676478642123	0.529042076572987	PSAP/NR2F2/S100A9/PYGL	4
GO:0035064	methylated histone binding	4/588	73/18367	0.205676478642123	0.529042076572987	BPTF/ATRX/KDM5A/MPHOSPH8	4
GO:0106306	protein serine phosphatase activity	4/588	73/18367	0.205676478642123	0.529042076572987	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0106307	protein threonine phosphatase activity	4/588	73/18367	0.205676478642123	0.529042076572987	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0140034	methylation-dependent protein binding	4/588	73/18367	0.205676478642123	0.529042076572987	BPTF/ATRX/KDM5A/MPHOSPH8	4
GO:0140104	molecular carrier activity	4/588	73/18367	0.205676478642123	0.529042076572987	EMC1/EMC10/HSPA8/RAN	4
GO:0140677	molecular function activator activity	7/588	150/18367	0.206016624070457	0.529042076572987	PSAP/MMP15/CTSA/DDOST/CALM1/DNAJB1/CALM2	7
GO:0019212	phosphatase inhibitor activity	3/588	49/18367	0.206578739282111	0.529042076572987	BOD1L1/PPP1R10/PHACTR2	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6/588	124/18367	0.206958598508426	0.529042076572987	LDHA/HMGCR/HSD17B1/HADHA/HPGD/DHRS2	6
GO:0005254	chloride channel activity	4/588	74/18367	0.212381467870847	0.532344464661002	CLDN4/GABRE/FXYD3/CLIC3	4
GO:0019905	syntaxin binding	4/588	74/18367	0.212381467870847	0.532344464661002	TMED9/SLC6A4/VAMP2/RAB11A	4
GO:0015215	nucleotide transmembrane transporter activity	2/588	27/18367	0.213618568687371	0.532344464661002	SLC19A1/SLC25A36	2
GO:0015491	cation:cation antiporter activity	2/588	27/18367	0.213618568687371	0.532344464661002	SLC3A2/SLC9A1	2
GO:0016405	CoA-ligase activity	2/588	27/18367	0.213618568687371	0.532344464661002	ACSS1/SLC27A2	2
GO:0035255	ionotropic glutamate receptor binding	2/588	27/18367	0.213618568687371	0.532344464661002	FUS/CANX	2
GO:0051119	sugar transmembrane transporter activity	2/588	27/18367	0.213618568687371	0.532344464661002	SLC2A1/SLC2A8	2
GO:0070006	metalloaminopeptidase activity	2/588	27/18367	0.213618568687371	0.532344464661002	ENPEP/MMP15	2
GO:0015485	cholesterol binding	3/588	50/18367	0.214946632900857	0.532344464661002	CD81/CAV1/VDAC1	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3/588	50/18367	0.214946632900857	0.532344464661002	SLC19A1/SLC25A36/HNRNPA3	3
GO:0005496	steroid binding	5/588	100/18367	0.216876239669025	0.535455312226319	ESRRA/CD81/CAV1/HSD17B1/VDAC1	5
GO:0004601	peroxidase activity	3/588	51/18367	0.223384803364522	0.54812011936665	MGST3/GPX3/GPX1	3
GO:0051018	protein kinase A binding	3/588	51/18367	0.223384803364522	0.54812011936665	AKAP9/CRYBG3/WASF2	3
GO:0003785	actin monomer binding	2/588	28/18367	0.225500831583528	0.5482359666939	TMSB4X/PFN1	2
GO:0004629	phospholipase C activity	2/588	28/18367	0.225500831583528	0.5482359666939	PDIA3/NOTUM	2
GO:0051861	glycolipid binding	2/588	28/18367	0.225500831583528	0.5482359666939	GPAA1/PSAP	2
GO:0022804	active transmembrane transporter activity	16/588	406/18367	0.23123806427156	0.555271292582986	ATP2B1/SLC26A2/COX6A1/SLC3A2/SLC22A11/SLC38A2/SLC1A5/SLC12A9/SLC38A1/SLC9A1/SLC19A1/SLC13A4/SLC16A12/SLC6A4/NDUFB9/UQCRH	16
GO:0004879	nuclear receptor activity	3/588	52/18367	0.231886879418303	0.555271292582986	ESRRA/NR2F2/NR2F6	3
GO:0017046	peptide hormone binding	3/588	52/18367	0.231886879418303	0.555271292582986	IGF1R/SLC40A1/PRLR	3
GO:0098531	ligand-activated transcription factor activity	3/588	52/18367	0.231886879418303	0.555271292582986	ESRRA/NR2F2/NR2F6	3
GO:1901682	sulfur compound transmembrane transporter activity	3/588	52/18367	0.231886879418303	0.555271292582986	SLC26A2/GJA1/SLC13A4	3
GO:0015301	anion:anion antiporter activity	2/588	29/18367	0.237429432984456	0.563451937978038	SLC26A2/SLC19A1	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/588	29/18367	0.237429432984456	0.563451937978038	DHCR24/PTGES2	2
GO:0046625	sphingolipid binding	2/588	29/18367	0.237429432984456	0.563451937978038	PSAP/VDAC1	2
GO:0015294	solute:cation symporter activity	5/588	104/18367	0.240387629361547	0.568774301614374	SLC38A2/SLC12A9/SLC38A1/SLC13A4/SLC6A4	5
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	3/588	54/18367	0.249057873981282	0.584850914039903	P4HB/KDM5A/ASPH	3
GO:0005343	organic acid:sodium symporter activity	2/588	30/18367	0.24938925768494	0.584850914039903	SLC38A2/SLC38A1	2
GO:0017147	Wnt-protein binding	2/588	30/18367	0.24938925768494	0.584850914039903	WLS/LRP5	2
GO:0140030	modification-dependent protein binding	7/588	160/18367	0.253127506314402	0.590516519725386	BPTF/ATRX/PHIP/KDM5A/BRD4/MPHOSPH8/AGL	7
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3/588	55/18367	0.257714676790208	0.590516519725386	MGST3/GPX3/GPX1	3
GO:0016878	acid-thiol ligase activity	2/588	31/18367	0.261366107671209	0.590516519725386	ACSS1/SLC27A2	2
GO:0042910	xenobiotic transmembrane transporter activity	2/588	31/18367	0.261366107671209	0.590516519725386	SLC2A1/SLC19A1	2
GO:0140318	protein transporter activity	2/588	31/18367	0.261366107671209	0.590516519725386	LRP2/IGF1R	2
GO:0008234	cysteine-type peptidase activity	8/588	190/18367	0.264664212437504	0.590516519725386	CTSL/CTSD/GPAA1/CTSC/CTSV/PDIA3/LGMN/EIF3H	8
GO:0043177	organic acid binding	6/588	135/18367	0.264665913939469	0.590516519725386	GLDC/FOLR1/SLC19A1/NR2F2/S100A9/TYMS	6
GO:0042054	histone methyltransferase activity	3/588	56/18367	0.266411162944933	0.590516519725386	KMT2C/NSD1/FBL	3
GO:0045309	protein phosphorylated amino acid binding	3/588	56/18367	0.266411162944933	0.590516519725386	PFN1/RASA1/YWHAE	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	6/588	136/18367	0.270112647819738	0.590516519725386	LDHA/HMGCR/HSD17B1/HADHA/HPGD/DHRS2	6
GO:0001223	transcription coactivator binding	2/588	32/18367	0.273346659054543	0.590516519725386	RPL23/VGLL4	2
GO:0015605	organophosphate ester transmembrane transporter activity	2/588	32/18367	0.273346659054543	0.590516519725386	SLC19A1/SLC25A36	2
GO:0030332	cyclin binding	2/588	32/18367	0.273346659054543	0.590516519725386	CDK6/CDK1	2
GO:0031624	ubiquitin conjugating enzyme binding	2/588	32/18367	0.273346659054543	0.590516519725386	SIAH1/SIAH2	2
GO:0051721	protein phosphatase 2A binding	2/588	32/18367	0.273346659054543	0.590516519725386	BOD1L1/HMGCR	2
GO:0001094	TFIID-class transcription factor complex binding	1/588	10/18367	0.277802740097226	0.590516519725386	FBL	1
GO:0004955	prostaglandin receptor activity	1/588	10/18367	0.277802740097226	0.590516519725386	HPGD	1
GO:0005432	calcium:sodium antiporter activity	1/588	10/18367	0.277802740097226	0.590516519725386	SLC3A2	1
GO:0005522	profilin binding	1/588	10/18367	0.277802740097226	0.590516519725386	ACTG1	1
GO:0008190	eukaryotic initiation factor 4E binding	1/588	10/18367	0.277802740097226	0.590516519725386	EIF4G1	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/588	10/18367	0.277802740097226	0.590516519725386	SLC3A2	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/588	10/18367	0.277802740097226	0.590516519725386	MAN1A2	1
GO:0016175	superoxide-generating NAD(P)H oxidase activity	1/588	10/18367	0.277802740097226	0.590516519725386	CYBA	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/588	10/18367	0.277802740097226	0.590516519725386	POR	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/588	10/18367	0.277802740097226	0.590516519725386	DEGS1	1
GO:0019531	oxalate transmembrane transporter activity	1/588	10/18367	0.277802740097226	0.590516519725386	SLC26A2	1
GO:0030957	Tat protein binding	1/588	10/18367	0.277802740097226	0.590516519725386	NPM1	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/588	10/18367	0.277802740097226	0.590516519725386	SLC27A2	1
GO:0034511	U3 snoRNA binding	1/588	10/18367	0.277802740097226	0.590516519725386	PRKDC	1
GO:0035612	AP-2 adaptor complex binding	1/588	10/18367	0.277802740097226	0.590516519725386	AAK1	1
GO:0043208	glycosphingolipid binding	1/588	10/18367	0.277802740097226	0.590516519725386	PSAP	1
GO:0070008	serine-type exopeptidase activity	1/588	10/18367	0.277802740097226	0.590516519725386	CTSA	1
GO:0070016	armadillo repeat domain binding	1/588	10/18367	0.277802740097226	0.590516519725386	TCF7L2	1
GO:0097027	ubiquitin-protein transferase activator activity	1/588	10/18367	0.277802740097226	0.590516519725386	UBE2L3	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/588	10/18367	0.277802740097226	0.590516519725386	ADRB1	1
GO:0001530	lipopolysaccharide binding	2/588	33/18367	0.285318420814776	0.593262365474267	NINJ1/HMGB1	2
GO:0031369	translation initiation factor binding	2/588	33/18367	0.285318420814776	0.593262365474267	EIF4G1/EIF2S2	2
GO:0140323	solute:anion antiporter activity	2/588	33/18367	0.285318420814776	0.593262365474267	SLC26A2/SLC19A1	2
GO:0050660	flavin adenine dinucleotide binding	4/588	85/18367	0.289389510506897	0.593262365474267	DHCR24/ILVBL/POR/ACADVL	4
GO:0015020	glucuronosyltransferase activity	2/588	34/18367	0.297269695282261	0.593262365474267	CHPF/B3GAT3	2
GO:0043548	phosphatidylinositol 3-kinase binding	2/588	34/18367	0.297269695282261	0.593262365474267	IGF1R/CALM1	2
GO:0004954	prostanoid receptor activity	1/588	11/18367	0.30093571328581	0.593262365474267	HPGD	1
GO:0005049	nuclear export signal receptor activity	1/588	11/18367	0.30093571328581	0.593262365474267	RAN	1
GO:0005078	MAP-kinase scaffold activity	1/588	11/18367	0.30093571328581	0.593262365474267	IQGAP1	1
GO:0008503	benzodiazepine receptor activity	1/588	11/18367	0.30093571328581	0.593262365474267	GABRE	1
GO:0015368	calcium:cation antiporter activity	1/588	11/18367	0.30093571328581	0.593262365474267	SLC3A2	1
GO:0015378	sodium:chloride symporter activity	1/588	11/18367	0.30093571328581	0.593262365474267	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/588	11/18367	0.30093571328581	0.593262365474267	SLC9A1	1
GO:0016832	aldehyde-lyase activity	1/588	11/18367	0.30093571328581	0.593262365474267	ALDOA	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/588	11/18367	0.30093571328581	0.593262365474267	HSD17B1	1
GO:0031996	thioesterase binding	1/588	11/18367	0.30093571328581	0.593262365474267	CDC42	1
GO:0032052	bile acid binding	1/588	11/18367	0.30093571328581	0.593262365474267	PYGL	1
GO:0032404	mismatch repair complex binding	1/588	11/18367	0.30093571328581	0.593262365474267	PCNA	1
GO:0035673	oligopeptide transmembrane transporter activity	1/588	11/18367	0.30093571328581	0.593262365474267	GJA1	1
GO:0043295	glutathione binding	1/588	11/18367	0.30093571328581	0.593262365474267	PTGES2	1
GO:0043522	leucine zipper domain binding	1/588	11/18367	0.30093571328581	0.593262365474267	DDIT3	1
GO:0046975	histone methyltransferase activity (H3-K36 specific)	1/588	11/18367	0.30093571328581	0.593262365474267	NSD1	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/588	11/18367	0.30093571328581	0.593262365474267	TXN	1
GO:0047429	nucleoside-triphosphate diphosphatase activity	1/588	11/18367	0.30093571328581	0.593262365474267	DUT	1
GO:0047676	arachidonate-CoA ligase activity	1/588	11/18367	0.30093571328581	0.593262365474267	SLC27A2	1
GO:0097371	MDM2/MDM4 family protein binding	1/588	11/18367	0.30093571328581	0.593262365474267	RPS20	1
GO:0099186	structural constituent of postsynapse	1/588	11/18367	0.30093571328581	0.593262365474267	ACTG1	1
GO:1990459	transferrin receptor binding	1/588	11/18367	0.30093571328581	0.593262365474267	CD81	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/588	60/18367	0.301481755536609	0.593262365474267	DHCR24/PTGES2/ACADVL	3
GO:0032934	sterol binding	3/588	60/18367	0.301481755536609	0.593262365474267	CD81/CAV1/VDAC1	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	7/588	170/18367	0.303053597957601	0.594882988583438	P4HB/POR/KDM5A/CYP20A1/ASPH/DEGS1/CYP2J2	7
GO:0004175	endopeptidase activity	16/588	430/18367	0.304239635870345	0.595740173687006	ADAMTS6/CTSL/CTSD/GPAA1/NCSTN/CTSC/MMP15/ADAMTS1/CTSV/DPP4/PDIA3/SPPL2A/TMEM59/PRSS8/LGMN/HM13	16
GO:0008194	UDP-glycosyltransferase activity	6/588	143/18367	0.308927761817822	0.600991893716905	CHPF/HEXA/EXTL2/B3GAT3/GALNT11/MGAT1	6
GO:0015298	solute:cation antiporter activity	2/588	35/18367	0.309189540289578	0.600991893716905	SLC3A2/SLC9A1	2
GO:0042887	amide transmembrane transporter activity	2/588	35/18367	0.309189540289578	0.600991893716905	GJA1/SLC19A1	2
GO:0005507	copper ion binding	3/588	61/18367	0.310293790377011	0.601667227682253	F5/SOD3/GPC1	3
GO:0061659	ubiquitin-like protein ligase activity	12/588	316/18367	0.313927809744042	0.603395529696126	UFL1/NHLRC3/RNF43/MYCBP2/ZNRF3/RBBP6/HECTD1/SIAH1/MYLIP/SIAH2/CDC42/ANAPC11	12
GO:0015297	antiporter activity	4/588	89/18367	0.318361616184316	0.603395529696126	SLC26A2/SLC3A2/SLC9A1/SLC19A1	4
GO:0003964	RNA-directed DNA polymerase activity	1/588	12/18367	0.323328925346604	0.603395529696126	PTGES3	1
GO:0003995	acyl-CoA dehydrogenase activity	1/588	12/18367	0.323328925346604	0.603395529696126	ACADVL	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/588	12/18367	0.323328925346604	0.603395529696126	CDKN1C	1
GO:0015269	calcium-activated potassium channel activity	1/588	12/18367	0.323328925346604	0.603395529696126	KCNN4	1
GO:0022858	alanine transmembrane transporter activity	1/588	12/18367	0.323328925346604	0.603395529696126	SLC3A2	1
GO:0030955	potassium ion binding	1/588	12/18367	0.323328925346604	0.603395529696126	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/588	12/18367	0.323328925346604	0.603395529696126	P4HB	1
GO:0035256	G protein-coupled glutamate receptor binding	1/588	12/18367	0.323328925346604	0.603395529696126	CALM1	1
GO:0035325	Toll-like receptor binding	1/588	12/18367	0.323328925346604	0.603395529696126	S100A9	1
GO:0043176	amine binding	1/588	12/18367	0.323328925346604	0.603395529696126	SLC6A4	1
GO:0043422	protein kinase B binding	1/588	12/18367	0.323328925346604	0.603395529696126	SRSF5	1
GO:0046790	virion binding	1/588	12/18367	0.323328925346604	0.603395529696126	PPIA	1
GO:0051378	serotonin binding	1/588	12/18367	0.323328925346604	0.603395529696126	SLC6A4	1
GO:1900750	oligopeptide binding	1/588	12/18367	0.323328925346604	0.603395529696126	PTGES2	1
GO:0005109	frizzled binding	2/588	37/18367	0.332894734837011	0.614977051770857	RNF43/ZNRF3	2
GO:0019842	vitamin binding	6/588	148/18367	0.337209181043611	0.614977051770857	GLDC/FOLR1/ILVBL/SLC19A1/TYMS/PYGL	6
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/588	38/18367	0.344661658990009	0.614977051770857	SIAH1/SIAH2	2
GO:0002161	aminoacyl-tRNA editing activity	1/588	13/18367	0.345005993823651	0.614977051770857	IARS2	1
GO:0008195	phosphatidate phosphatase activity	1/588	13/18367	0.345005993823651	0.614977051770857	PLPP3	1
GO:0015385	sodium:proton antiporter activity	1/588	13/18367	0.345005993823651	0.614977051770857	SLC9A1	1
GO:0016594	glycine binding	1/588	13/18367	0.345005993823651	0.614977051770857	GLDC	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/588	13/18367	0.345005993823651	0.614977051770857	TXN	1
GO:0016840	carbon-nitrogen lyase activity	1/588	13/18367	0.345005993823651	0.614977051770857	APMAP	1
GO:0019104	DNA N-glycosylase activity	1/588	13/18367	0.345005993823651	0.614977051770857	PCNA	1
GO:0022851	GABA-gated chloride ion channel activity	1/588	13/18367	0.345005993823651	0.614977051770857	GABRE	1
GO:0031386	protein tag	1/588	13/18367	0.345005993823651	0.614977051770857	UBA52	1
GO:0031404	chloride ion binding	1/588	13/18367	0.345005993823651	0.614977051770857	CTSC	1
GO:0032036	myosin heavy chain binding	1/588	13/18367	0.345005993823651	0.614977051770857	MYL12B	1
GO:0034450	ubiquitin-ubiquitin ligase activity	1/588	13/18367	0.345005993823651	0.614977051770857	ANAPC11	1
GO:0045159	myosin II binding	1/588	13/18367	0.345005993823651	0.614977051770857	TRIOBP	1
GO:0051011	microtubule minus-end binding	1/588	13/18367	0.345005993823651	0.614977051770857	MACF1	1
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	1/588	13/18367	0.345005993823651	0.614977051770857	CKS1B	1
GO:0070700	BMP receptor binding	1/588	13/18367	0.345005993823651	0.614977051770857	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/588	13/18367	0.345005993823651	0.614977051770857	HSD17B1	1
GO:0001664	G protein-coupled receptor binding	11/588	295/18367	0.346046077735868	0.615451077852382	ITGB4/RNF43/WLS/ZNRF3/HSPA1A/ADRB1/ADM/GNAQ/CALM1/GNAI2/HSPA8	11
GO:0005179	hormone activity	5/588	122/18367	0.3523431925087	0.625251870634858	FBN1/ADM/CSH1/COPA/IGF2	5
GO:0004674	protein serine/threonine kinase activity	14/588	386/18367	0.354743243536917	0.626784046708038	EGFR/AAK1/LTBP1/TGFBR3/PRKDC/ROCK1/PKN2/BRD4/CDK6/EIF2AK4/CCND3/PRKCZ/CDK1/CSNK2B	14
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/588	39/18367	0.356360237876771	0.626784046708038	POLR2J3/POLR2A	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/588	39/18367	0.356360237876771	0.626784046708038	IQGAP2/IQGAP1	2
GO:0050997	quaternary ammonium group binding	2/588	39/18367	0.356360237876771	0.626784046708038	ILVBL/VDAC1	2
GO:0015081	sodium ion transmembrane transporter activity	6/588	152/18367	0.360037351876944	0.628427382027404	SLC3A2/SLC38A2/SLC38A1/SLC9A1/SLC13A4/SLC6A4	6
GO:0016757	glycosyltransferase activity	10/588	270/18367	0.364605923726659	0.628427382027404	CHPF/RPN2/HEXA/EXTL2/B3GAT3/C1GALT1/GALNT11/MGAT1/AGL/PYGL	10
GO:0005451	monovalent cation:proton antiporter activity	1/588	14/18367	0.365989783495205	0.628427382027404	SLC9A1	1
GO:0015562	efflux transmembrane transporter activity	1/588	14/18367	0.365989783495205	0.628427382027404	GJA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/588	14/18367	0.365989783495205	0.628427382027404	MIF	1
GO:0030983	mismatched DNA binding	1/588	14/18367	0.365989783495205	0.628427382027404	PCNA	1
GO:0035259	glucocorticoid receptor binding	1/588	14/18367	0.365989783495205	0.628427382027404	YWHAH	1
GO:0036041	long-chain fatty acid binding	1/588	14/18367	0.365989783495205	0.628427382027404	S100A9	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/588	14/18367	0.365989783495205	0.628427382027404	HSD17B1	1
GO:0071837	HMG box domain binding	1/588	14/18367	0.365989783495205	0.628427382027404	JUN	1
GO:0140666	annealing activity	1/588	14/18367	0.365989783495205	0.628427382027404	EIF4B	1
GO:0015144	carbohydrate transmembrane transporter activity	2/588	40/18367	0.367982793066628	0.629131872017139	SLC2A1/SLC2A8	2
GO:0031492	nucleosomal DNA binding	2/588	40/18367	0.367982793066628	0.629131872017139	HMGN3/HNRNPC	2
GO:0008017	microtubule binding	10/588	271/18367	0.368893801636765	0.629335992062722	GAPDH/MACF1/CLIP1/DST/KIF5B/CENPF/HOOK2/S100A9/CNN3/RAB11A	10
GO:0004896	cytokine receptor activity	4/588	97/18367	0.376768139475986	0.631553995795579	CSF3R/IL10RB/PRLR/IL6ST	4
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/588	41/18367	0.379522206073542	0.631553995795579	ACSS1/SLC27A2	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/588	41/18367	0.379522206073542	0.631553995795579	COL14A1/COL4A2	2
GO:0003777	microtubule motor activity	3/588	69/18367	0.380675394086988	0.631553995795579	DYNC1H1/KIF5B/DYNLRB1	3
GO:0061630	ubiquitin protein ligase activity	11/588	304/18367	0.382621279837835	0.631553995795579	NHLRC3/RNF43/MYCBP2/ZNRF3/RBBP6/HECTD1/SIAH1/MYLIP/SIAH2/CDC42/ANAPC11	11
GO:0004722	protein serine/threonine phosphatase activity	4/588	98/18367	0.384060248660948	0.631553995795579	DUSP1/DUSP6/DUSP9/CTDSPL	4
GO:0001846	opsonin binding	1/588	15/18367	0.386302430327048	0.631553995795579	ITGAV	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/588	15/18367	0.386302430327048	0.631553995795579	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/588	15/18367	0.386302430327048	0.631553995795579	MAN1A2	1
GO:0004953	icosanoid receptor activity	1/588	15/18367	0.386302430327048	0.631553995795579	HPGD	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/588	15/18367	0.386302430327048	0.631553995795579	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/588	15/18367	0.386302430327048	0.631553995795579	SLC22A11	1
GO:0016846	carbon-sulfur lyase activity	1/588	15/18367	0.386302430327048	0.631553995795579	MGST3	1
GO:0032794	GTPase activating protein binding	1/588	15/18367	0.386302430327048	0.631553995795579	CDH1	1
GO:0042813	Wnt-activated receptor activity	1/588	15/18367	0.386302430327048	0.631553995795579	LRP5	1
GO:0048185	activin binding	1/588	15/18367	0.386302430327048	0.631553995795579	TGFBR3	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1/588	15/18367	0.386302430327048	0.631553995795579	CYBA	1
GO:0051139	metal ion:proton antiporter activity	1/588	15/18367	0.386302430327048	0.631553995795579	SLC9A1	1
GO:0070742	C2H2 zinc finger domain binding	1/588	15/18367	0.386302430327048	0.631553995795579	SRRM2	1
GO:1904680	peptide transmembrane transporter activity	1/588	15/18367	0.386302430327048	0.631553995795579	GJA1	1
GO:0001098	basal transcription machinery binding	3/588	70/18367	0.389394172731749	0.631553995795579	BRD4/NCOA3/FBL	3
GO:0001099	basal RNA polymerase II transcription machinery binding	3/588	70/18367	0.389394172731749	0.631553995795579	BRD4/NCOA3/FBL	3
GO:0001046	core promoter sequence-specific DNA binding	2/588	42/18367	0.390971890478824	0.631553995795579	FOS/NPM1	2
GO:0019001	guanyl nucleotide binding	14/588	398/18367	0.397730393637794	0.631553995795579	RHOB/EEF1A1/GNAQ/SLC19A1/ARL4A/TUFM/GNAI2/ARF5/RHOA/TUBA1B/RAN/CDC42/RAB11A/TUBA1C	14
GO:0032561	guanyl ribonucleotide binding	14/588	398/18367	0.397730393637794	0.631553995795579	RHOB/EEF1A1/GNAQ/SLC19A1/ARL4A/TUFM/GNAI2/ARF5/RHOA/TUBA1B/RAN/CDC42/RAB11A/TUBA1C	14
GO:0018024	histone-lysine N-methyltransferase activity	2/588	43/18367	0.402325765259967	0.631553995795579	KMT2C/NSD1	2
GO:0034062	5'-3' RNA polymerase activity	2/588	43/18367	0.402325765259967	0.631553995795579	POLR2J3/POLR2A	2
GO:0097747	RNA polymerase activity	2/588	43/18367	0.402325765259967	0.631553995795579	POLR2J3/POLR2A	2
GO:0017124	SH3 domain binding	5/588	130/18367	0.403332950026896	0.631553995795579	LRP2/GJA1/WASF2/GPX1/CYBA	5
GO:0046873	metal ion transmembrane transporter activity	15/588	430/18367	0.404016467864146	0.631553995795579	ATP2B1/SLC39A10/ITGAV/KCNN4/SLC3A2/SLC38A2/SLC12A9/SLC38A1/SLC9A1/SLC13A4/SLC40A1/SLC6A4/SLC39A7/TUSC3/SLC39A1	15
GO:0005092	GDP-dissociation inhibitor activity	1/588	16/18367	0.405965364664869	0.631553995795579	RANBP1	1
GO:0008191	metalloendopeptidase inhibitor activity	1/588	16/18367	0.405965364664869	0.631553995795579	TIMP3	1
GO:0010181	FMN binding	1/588	16/18367	0.405965364664869	0.631553995795579	POR	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/588	16/18367	0.405965364664869	0.631553995795579	SLC1A5	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/588	16/18367	0.405965364664869	0.631553995795579	SLC22A11	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/588	16/18367	0.405965364664869	0.631553995795579	SLC1A5	1
GO:0022821	potassium ion antiporter activity	1/588	16/18367	0.405965364664869	0.631553995795579	SLC9A1	1
GO:0032183	SUMO binding	1/588	16/18367	0.405965364664869	0.631553995795579	SERBP1	1
GO:0035173	histone kinase activity	1/588	16/18367	0.405965364664869	0.631553995795579	CDK1	1
GO:0035497	cAMP response element binding	1/588	16/18367	0.405965364664869	0.631553995795579	JUN	1
GO:0042577	lipid phosphatase activity	1/588	16/18367	0.405965364664869	0.631553995795579	PLPP3	1
GO:0070402	NADPH binding	1/588	16/18367	0.405965364664869	0.631553995795579	HMGCR	1
GO:0070492	oligosaccharide binding	1/588	16/18367	0.405965364664869	0.631553995795579	CHID1	1
GO:0140327	flippase activity	1/588	16/18367	0.405965364664869	0.631553995795579	ATP10D	1
GO:0008235	metalloexopeptidase activity	3/588	72/18367	0.406736661443191	0.631553995795579	ENPEP/MMP15/TFRC	3
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	3/588	72/18367	0.406736661443191	0.631553995795579	COX6A1/NDUFB9/UQCRH	3
GO:0000287	magnesium ion binding	8/588	221/18367	0.412680131169657	0.636298437445225	ENO1/ILVBL/ATP10D/PKM/DUT/S100P/PGP/RAN	8
GO:0001784	phosphotyrosine residue binding	2/588	44/18367	0.413578229277131	0.636298437445225	PFN1/RASA1	2
GO:0030546	signaling receptor activator activity	17/588	495/18367	0.418330793440552	0.636298437445225	FBN1/GRN/EFEMP1/SEMA6A/APP/SEMA6D/LRPAP1/ADM/DPP4/CSH1/COPA/BMP7/MIF/FAM3B/HMGB1/IGF2/HMGB2	17
GO:0048156	tau protein binding	2/588	45/18367	0.424724136870696	0.636298437445225	ROCK1/LGMN	2
GO:0005005	transmembrane-ephrin receptor activity	1/588	17/18367	0.42499933368983	0.636298437445225	EPHB4	1
GO:0008308	voltage-gated anion channel activity	1/588	17/18367	0.42499933368983	0.636298437445225	VDAC1	1
GO:0008392	arachidonic acid epoxygenase activity	1/588	17/18367	0.42499933368983	0.636298437445225	CYP2J2	1
GO:0008484	sulfuric ester hydrolase activity	1/588	17/18367	0.42499933368983	0.636298437445225	GNS	1
GO:0008574	plus-end-directed microtubule motor activity	1/588	17/18367	0.42499933368983	0.636298437445225	KIF5B	1
GO:0015095	magnesium ion transmembrane transporter activity	1/588	17/18367	0.42499933368983	0.636298437445225	TUSC3	1
GO:0015108	chloride transmembrane transporter activity	1/588	17/18367	0.42499933368983	0.636298437445225	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/588	17/18367	0.42499933368983	0.636298437445225	SLC38A9	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/588	17/18367	0.42499933368983	0.636298437445225	FTH1	1
GO:0030275	LRR domain binding	1/588	17/18367	0.42499933368983	0.636298437445225	DDIT3	1
GO:0031420	alkali metal ion binding	1/588	17/18367	0.42499933368983	0.636298437445225	PKM	1
GO:0042800	histone methyltransferase activity (H3-K4 specific)	1/588	17/18367	0.42499933368983	0.636298437445225	KMT2C	1
GO:0043395	heparan sulfate proteoglycan binding	1/588	17/18367	0.42499933368983	0.636298437445225	LRP1	1
GO:0048531	beta-1,3-galactosyltransferase activity	1/588	17/18367	0.42499933368983	0.636298437445225	C1GALT1	1
GO:0070628	proteasome binding	1/588	17/18367	0.42499933368983	0.636298437445225	ID1	1
GO:0005525	GTP binding	13/588	377/18367	0.432115828570812	0.645042478534471	RHOB/EEF1A1/GNAQ/ARL4A/TUFM/GNAI2/ARF5/RHOA/TUBA1B/RAN/CDC42/RAB11A/TUBA1C	13
GO:0019003	GDP binding	3/588	75/18367	0.432462441583488	0.645042478534471	RHOB/RHOA/RAN	3
GO:0140296	general transcription initiation factor binding	2/588	46/18367	0.435758774525101	0.648741995781752	BDP1/FBL	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/588	18/18367	0.443424423160695	0.649212553246322	SLC19A1	1
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/588	18/18367	0.443424423160695	0.649212553246322	HSD17B1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/588	18/18367	0.443424423160695	0.649212553246322	SLC19A1	1
GO:0008409	5'-3' exonuclease activity	1/588	18/18367	0.443424423160695	0.649212553246322	PLD3	1
GO:0008569	minus-end-directed microtubule motor activity	1/588	18/18367	0.443424423160695	0.649212553246322	DYNC1H1	1
GO:0046624	sphingolipid transporter activity	1/588	18/18367	0.443424423160695	0.649212553246322	ATP10D	1
GO:0070122	isopeptidase activity	1/588	18/18367	0.443424423160695	0.649212553246322	EIF3H	1
GO:0098918	structural constituent of synapse	1/588	18/18367	0.443424423160695	0.649212553246322	ACTG1	1
GO:0099095	ligand-gated anion channel activity	1/588	18/18367	0.443424423160695	0.649212553246322	GABRE	1
GO:0005044	scavenger receptor activity	2/588	47/18367	0.446677838555861	0.651575929636532	LRP1/LGALS3BP	2
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/588	47/18367	0.446677838555861	0.651575929636532	GABRE/ADRB1	2
GO:0004129	cytochrome-c oxidase activity	1/588	19/18367	0.461260078465154	0.664314786919923	COX6A1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/588	19/18367	0.461260078465154	0.664314786919923	GALNT11	1
GO:0004890	GABA-A receptor activity	1/588	19/18367	0.461260078465154	0.664314786919923	GABRE	1
GO:0005003	ephrin receptor activity	1/588	19/18367	0.461260078465154	0.664314786919923	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/588	19/18367	0.461260078465154	0.664314786919923	SLC6A4	1
GO:0035613	RNA stem-loop binding	1/588	19/18367	0.461260078465154	0.664314786919923	MYH10	1
GO:0035615	clathrin adaptor activity	1/588	19/18367	0.461260078465154	0.664314786919923	AP1S1	1
GO:0000149	SNARE binding	4/588	110/18367	0.470150423807508	0.673575018073501	TMED9/SLC6A4/VAMP2/RAB11A	4
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	15/588	450/18367	0.473728849044069	0.673575018073501	JUN/FOS/FOSB/JUND/EGR1/SOX4/ZNF208/ISL1/NFAT5/PBX1/DDIT3/TBX3/JUNB/TFAP2A/E2F4	15
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/588	20/18367	0.478525125002242	0.673575018073501	FOS	1
GO:0001091	RNA polymerase II general transcription initiation factor binding	1/588	20/18367	0.478525125002242	0.673575018073501	FBL	1
GO:0001972	retinoic acid binding	1/588	20/18367	0.478525125002242	0.673575018073501	NR2F2	1
GO:0016408	C-acyltransferase activity	1/588	20/18367	0.478525125002242	0.673575018073501	HADHA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/588	20/18367	0.478525125002242	0.673575018073501	CTSC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/588	20/18367	0.478525125002242	0.673575018073501	GLDC	1
GO:0030296	protein tyrosine kinase activator activity	1/588	20/18367	0.478525125002242	0.673575018073501	ERBB3	1
GO:0031681	G-protein beta-subunit binding	1/588	20/18367	0.478525125002242	0.673575018073501	GNG5	1
GO:0031690	adrenergic receptor binding	1/588	20/18367	0.478525125002242	0.673575018073501	ADRB1	1
GO:0140312	cargo adaptor activity	1/588	20/18367	0.478525125002242	0.673575018073501	AP1S1	1
GO:0000993	RNA polymerase II complex binding	2/588	50/18367	0.478704258127708	0.673575018073501	BRD4/NCOA3	2
GO:0048018	receptor ligand activity	16/588	487/18367	0.493943959977391	0.689516709972128	FBN1/GRN/EFEMP1/SEMA6A/SEMA6D/LRPAP1/ADM/DPP4/CSH1/COPA/BMP7/MIF/FAM3B/HMGB1/IGF2/HMGB2	16
GO:0001216	DNA-binding transcription activator activity	15/588	456/18367	0.494494191204086	0.689516709972128	JUN/FOS/FOSB/JUND/EGR1/SOX4/ZNF208/ISL1/NFAT5/PBX1/DDIT3/TBX3/JUNB/TFAP2A/E2F4	15
GO:0008391	arachidonic acid monooxygenase activity	1/588	21/18367	0.495237787917088	0.689516709972128	CYP2J2	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/588	21/18367	0.495237787917088	0.689516709972128	SLC19A1	1
GO:0015662	P-type ion transporter activity	1/588	21/18367	0.495237787917088	0.689516709972128	ATP2B1	1
GO:0140358	P-type transmembrane transporter activity	1/588	21/18367	0.495237787917088	0.689516709972128	ATP2B1	1
GO:0003774	cytoskeletal motor activity	4/588	114/18367	0.497913703104128	0.691698480596823	DYNC1H1/MYH10/KIF5B/DYNLRB1	4
GO:0008146	sulfotransferase activity	2/588	52/18367	0.499415003600725	0.691698480596823	TPST2/CHST12	2
GO:0016830	carbon-carbon lyase activity	2/588	52/18367	0.499415003600725	0.691698480596823	ALDOA/PISD	2
GO:0001540	amyloid-beta binding	3/588	84/18367	0.506850318075098	0.693814830052525	LRP1/LRPAP1/ITM2B	3
GO:0042578	phosphoric ester hydrolase activity	12/588	366/18367	0.507878901787214	0.693814830052525	DUSP1/PLPP3/DUSP6/PTPRF/PDIA3/DUSP9/PLD3/NOTUM/PTPRA/CTDSPL/PGP/PHPT1	12
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/588	53/18367	0.50957062684671	0.693814830052525	SLC6A4/MFSD10	2
GO:0008649	rRNA methyltransferase activity	1/588	22/18367	0.511415711208528	0.693814830052525	FBL	1
GO:0015106	bicarbonate transmembrane transporter activity	1/588	22/18367	0.511415711208528	0.693814830052525	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/588	22/18367	0.511415711208528	0.693814830052525	SLC27A2	1
GO:0016917	GABA receptor activity	1/588	22/18367	0.511415711208528	0.693814830052525	GABRE	1
GO:0030742	GTP-dependent protein binding	1/588	22/18367	0.511415711208528	0.693814830052525	CDC42	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/588	22/18367	0.511415711208528	0.693814830052525	SERPINB9	1
GO:0050321	tau-protein kinase activity	1/588	22/18367	0.511415711208528	0.693814830052525	ROCK1	1
GO:0070034	telomerase RNA binding	1/588	22/18367	0.511415711208528	0.693814830052525	HNRNPC	1
GO:0140102	catalytic activity, acting on a rRNA	1/588	22/18367	0.511415711208528	0.693814830052525	FBL	1
GO:0005544	calcium-dependent phospholipid binding	2/588	54/18367	0.519590348110765	0.703704134153421	ANXA5/ANXA4	2
GO:0016791	phosphatase activity	9/588	275/18367	0.520790058792092	0.704129416224001	DUSP1/PLPP3/DUSP6/PTPRF/DUSP9/PTPRA/CTDSPL/PGP/PHPT1	9
GO:0004529	exodeoxyribonuclease activity	1/588	23/18367	0.527075976229481	0.706619563410518	PLD3	1
GO:0005212	structural constituent of eye lens	1/588	23/18367	0.527075976229481	0.706619563410518	CRYBG3	1
GO:0008143	poly(A) binding	1/588	23/18367	0.527075976229481	0.706619563410518	HNRNPDL	1
GO:0015299	solute:proton antiporter activity	1/588	23/18367	0.527075976229481	0.706619563410518	SLC9A1	1
GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/588	23/18367	0.527075976229481	0.706619563410518	PLD3	1
GO:0005080	protein kinase C binding	2/588	55/18367	0.529472448915314	0.707446381323823	ITGAV/DSP	2
GO:0030170	pyridoxal phosphate binding	2/588	55/18367	0.529472448915314	0.707446381323823	GLDC/PYGL	2
GO:0008276	protein methyltransferase activity	3/588	88/18367	0.538253507454228	0.713703510068694	KMT2C/NSD1/FBL	3
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3/588	88/18367	0.538253507454228	0.713703510068694	POR/NDUFB9/CYBA	3
GO:0051219	phosphoprotein binding	3/588	88/18367	0.538253507454228	0.713703510068694	PFN1/RASA1/YWHAE	3
GO:0030374	nuclear receptor coactivator activity	2/588	56/18367	0.539215459506809	0.713703510068694	CCAR1/NCOA3	2
GO:0070279	vitamin B6 binding	2/588	56/18367	0.539215459506809	0.713703510068694	GLDC/PYGL	2
GO:0003707	steroid hormone receptor activity	1/588	24/18367	0.54223511959936	0.713703510068694	ESRRA	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/588	24/18367	0.54223511959936	0.713703510068694	GAPDH	1
GO:0043495	protein-membrane adaptor activity	1/588	24/18367	0.54223511959936	0.713703510068694	SYNE2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/588	24/18367	0.54223511959936	0.713703510068694	BMP7	1
GO:0008081	phosphoric diester hydrolase activity	3/588	89/18367	0.545924154824108	0.716187628853409	PDIA3/PLD3/NOTUM	3
GO:0043178	alcohol binding	3/588	89/18367	0.545924154824108	0.716187628853409	CD81/CAV1/VDAC1	3
GO:0043175	RNA polymerase core enzyme binding	2/588	57/18367	0.548818144741337	0.718798064364684	BRD4/NCOA3	2
GO:0005160	transforming growth factor beta receptor binding	1/588	25/18367	0.556909150547165	0.72461992583469	TGFBR3	1
GO:0005227	calcium activated cation channel activity	1/588	25/18367	0.556909150547165	0.72461992583469	KCNN4	1
GO:0008266	poly(U) RNA binding	1/588	25/18367	0.556909150547165	0.72461992583469	HNRNPC	1
GO:0030247	polysaccharide binding	1/588	25/18367	0.556909150547165	0.72461992583469	AGL	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/588	58/18367	0.558279490616459	0.725216004967459	SLC27A2/SLC16A12	2
GO:0016279	protein-lysine N-methyltransferase activity	2/588	59/18367	0.567598691422503	0.735957030105952	KMT2C/NSD1	2
GO:0004364	glutathione transferase activity	1/588	26/18367	0.571113567703323	0.735957030105952	GSTO1	1
GO:0008198	ferrous iron binding	1/588	26/18367	0.571113567703323	0.735957030105952	FTH1	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/588	26/18367	0.571113567703323	0.735957030105952	SLC26A2	1
GO:0008237	metallopeptidase activity	6/588	190/18367	0.571176713931286	0.735957030105952	ADAMTS6/ENPEP/MMP15/ADAMTS1/TFRC/EIF3H	6
GO:0001786	phosphatidylserine binding	2/588	60/18367	0.576775137487534	0.740769360747317	HSPA8/HMGB1	2
GO:0016278	lysine N-methyltransferase activity	2/588	60/18367	0.576775137487534	0.740769360747317	KMT2C/NSD1	2
GO:0001671	ATPase activator activity	1/588	27/18367	0.584863375357783	0.7415731792814	DNAJB1	1
GO:0004709	MAP kinase kinase kinase activity	1/588	27/18367	0.584863375357783	0.7415731792814	EGFR	1
GO:0008139	nuclear localization sequence binding	1/588	27/18367	0.584863375357783	0.7415731792814	NFKBIA	1
GO:0016866	intramolecular transferase activity	1/588	27/18367	0.584863375357783	0.7415731792814	CYP2J2	1
GO:0022884	macromolecule transmembrane transporter activity	1/588	27/18367	0.584863375357783	0.7415731792814	HNRNPA3	1
GO:0043425	bHLH transcription factor binding	1/588	27/18367	0.584863375357783	0.7415731792814	ISL1	1
GO:0051393	alpha-actinin binding	1/588	27/18367	0.584863375357783	0.7415731792814	DAG1	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/588	27/18367	0.584863375357783	0.7415731792814	ATP10D	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/588	62/18367	0.59469823732424	0.752448756115527	GABRE/ADRB1	2
GO:0008083	growth factor activity	5/588	162/18367	0.595694329666598	0.752448756115527	GRN/EFEMP1/CSH1/BMP7/IGF2	5
GO:0008187	poly-pyrimidine tract binding	1/588	28/18367	0.598173099201274	0.752448756115527	HNRNPC	1
GO:0017056	structural constituent of nuclear pore	1/588	28/18367	0.598173099201274	0.752448756115527	TPR	1
GO:0050681	androgen receptor binding	1/588	28/18367	0.598173099201274	0.752448756115527	NSD1	1
GO:0008170	N-methyltransferase activity	3/588	97/18367	0.604506318637114	0.759214096866517	KMT2C/NSD1/FBL	3
GO:0019787	ubiquitin-like protein transferase activity	14/588	458/18367	0.608596774037531	0.761426578754071	UFL1/NHLRC3/RNF43/MYCBP2/ZNRF3/RBBP6/LMO7/HECTD1/SIAH1/MYLIP/SIAH2/CDC42/ANAPC11/UBE2L3	14
GO:0032452	histone demethylase activity	1/588	29/18367	0.61105680156616	0.761426578754071	KDM5A	1
GO:0033612	receptor serine/threonine kinase binding	1/588	29/18367	0.61105680156616	0.761426578754071	BMP7	1
GO:0070717	poly-purine tract binding	1/588	29/18367	0.61105680156616	0.761426578754071	HNRNPDL	1
GO:0140457	protein demethylase activity	1/588	29/18367	0.61105680156616	0.761426578754071	KDM5A	1
GO:0016779	nucleotidyltransferase activity	4/588	132/18367	0.613837427523982	0.763694452083827	POLR2J3/POLR2A/PTGES3/UGP2	4
GO:0030145	manganese ion binding	2/588	65/18367	0.620507003357183	0.77078604323275	EXTL2/MGAT1	2
GO:0005096	GTPase activator activity	14/588	462/18367	0.621580699178781	0.770915219730313	JUN/IQGAP2/IQGAP1/MYCBP2/ADRB1/GNAQ/HACD3/EEF1B2/FAM13A/NUCB1/ARHGAP21/RASA1/RGS10/RANBP1	14
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/588	30/18367	0.623528096182754	0.772125913497336	HSD17B1	1
GO:0002039	p53 binding	2/588	66/18367	0.628823690340101	0.777472525381618	BRD4/TRIM29	2
GO:0004842	ubiquitin-protein transferase activity	13/588	433/18367	0.633107045740027	0.778585715193907	NHLRC3/RNF43/MYCBP2/ZNRF3/RBBP6/LMO7/HECTD1/SIAH1/MYLIP/SIAH2/CDC42/ANAPC11/UBE2L3	13
GO:0005543	phospholipid binding	14/588	466/18367	0.634356463512312	0.778585715193907	IQGAP2/GPAA1/PSAP/IQGAP1/ANXA5/SPTBN1/SLC9A1/VAMP2/PHLDA2/PFN1/HSPA8/HMGB1/VDAC1/ANXA4	14
GO:0000146	microfilament motor activity	1/588	31/18367	0.635600162466472	0.778585715193907	MYH10	1
GO:0008157	protein phosphatase 1 binding	1/588	31/18367	0.635600162466472	0.778585715193907	PPP1R15A	1
GO:0031210	phosphatidylcholine binding	1/588	31/18367	0.635600162466472	0.778585715193907	VDAC1	1
GO:0140142	nucleocytoplasmic carrier activity	1/588	31/18367	0.635600162466472	0.778585715193907	RAN	1
GO:0016782	transferase activity, transferring sulphur-containing groups	2/588	68/18367	0.64503029788089	0.785636914021112	TPST2/CHST12	2
GO:0008378	galactosyltransferase activity	1/588	32/18367	0.647285759350728	0.785636914021112	C1GALT1	1
GO:0030515	snoRNA binding	1/588	32/18367	0.647285759350728	0.785636914021112	PRKDC	1
GO:0048019	receptor antagonist activity	1/588	32/18367	0.647285759350728	0.785636914021112	LRPAP1	1
GO:0050699	WW domain binding	1/588	32/18367	0.647285759350728	0.785636914021112	PRRG4	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/588	32/18367	0.647285759350728	0.785636914021112	ATRX	1
GO:0004620	phospholipase activity	3/588	104/18367	0.651489506051933	0.789533776389157	PDIA3/PLD3/NOTUM	3
GO:1901981	phosphatidylinositol phosphate binding	5/588	173/18367	0.653414555867136	0.790377083525937	IQGAP2/IQGAP1/SLC9A1/PHLDA2/PFN1	5
GO:0020037	heme binding	4/588	139/18367	0.654173737056688	0.790377083525937	CYP20A1/PTGES2/CYP2J2/CYBA	4
GO:1990782	protein tyrosine kinase binding	3/588	105/18367	0.657865842162115	0.792110143344299	ITGB1/EIF3A/PCNA	3
GO:0005154	epidermal growth factor receptor binding	1/588	33/18367	0.658597238679977	0.792110143344299	EFEMP1	1
GO:0051427	hormone receptor binding	1/588	33/18367	0.658597238679977	0.792110143344299	CSH1	1
GO:0004860	protein kinase inhibitor activity	2/588	70/18367	0.660672292459716	0.793405547591351	NPM1/CDKN1C	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	9/588	310/18367	0.664048675203827	0.796257461217258	JUN/NFE2L3/ENO1/PEG3/ZFHX3/IRX2/TBX3/NR2F6/TFAP2A	9
GO:0070851	growth factor receptor binding	4/588	141/18367	0.665165947132131	0.7963959758585	EFEMP1/APP/NCSTN/IL6ST	4
GO:0031491	nucleosome binding	2/588	71/18367	0.66828359292396	0.796840589447032	HMGN3/HNRNPC	2
GO:0016229	steroid dehydrogenase activity	1/588	34/18367	0.669546558176877	0.796840589447032	HSD17B1	1
GO:0016831	carboxy-lyase activity	1/588	34/18367	0.669546558176877	0.796840589447032	PISD	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/588	34/18367	0.669546558176877	0.796840589447032	CDKN1C	1
GO:0001217	DNA-binding transcription repressor activity	9/588	313/18367	0.675105518964769	0.801830310602832	JUN/NFE2L3/ENO1/PEG3/ZFHX3/IRX2/TBX3/NR2F6/TFAP2A	9
GO:0030276	clathrin binding	2/588	72/18367	0.675756362394839	0.801830310602832	LRP1/AP1S1	2
GO:0140375	immune receptor activity	4/588	144/18367	0.68120298711609	0.807088486970628	CSF3R/IL10RB/PRLR/IL6ST	4
GO:0019210	kinase inhibitor activity	2/588	74/18367	0.690290593631399	0.81074106210255	NPM1/CDKN1C	2
GO:0005484	SNAP receptor activity	1/588	36/18367	0.690404652884813	0.81074106210255	VAMP2	1
GO:0034061	DNA polymerase activity	1/588	36/18367	0.690404652884813	0.81074106210255	PTGES3	1
GO:0042605	peptide antigen binding	1/588	36/18367	0.690404652884813	0.81074106210255	DHCR24	1
GO:0042805	actinin binding	1/588	36/18367	0.690404652884813	0.81074106210255	DAG1	1
GO:0061631	ubiquitin conjugating enzyme activity	1/588	36/18367	0.690404652884813	0.81074106210255	UBE2L3	1
GO:0015399	primary active transmembrane transporter activity	5/588	181/18367	0.691940287483352	0.81134591231455	ATP2B1/SLC26A2/COX6A1/NDUFB9/UQCRH	5
GO:0004222	metalloendopeptidase activity	3/588	111/18367	0.694351928393487	0.811779092754151	ADAMTS6/MMP15/ADAMTS1	3
GO:0032182	ubiquitin-like protein binding	3/588	111/18367	0.694351928393487	0.811779092754151	N4BP2/CKS1B/SERBP1	3
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1/588	37/18367	0.700335483941697	0.811824205073965	GAPDH	1
GO:0030551	cyclic nucleotide binding	1/588	37/18367	0.700335483941697	0.811824205073965	SLC19A1	1
GO:0043531	ADP binding	1/588	37/18367	0.700335483941697	0.811824205073965	MYH10	1
GO:0071949	FAD binding	1/588	37/18367	0.700335483941697	0.811824205073965	DHCR24	1
GO:0030695	GTPase regulator activity	14/588	488/18367	0.700517490164453	0.811824205073965	JUN/IQGAP2/IQGAP1/MYCBP2/ADRB1/GNAQ/HACD3/EEF1B2/FAM13A/NUCB1/ARHGAP21/RASA1/RGS10/RANBP1	14
GO:0060589	nucleoside-triphosphatase regulator activity	14/588	488/18367	0.700517490164453	0.811824205073965	JUN/IQGAP2/IQGAP1/MYCBP2/ADRB1/GNAQ/HACD3/EEF1B2/FAM13A/NUCB1/ARHGAP21/RASA1/RGS10/RANBP1	14
GO:0046906	tetrapyrrole binding	4/588	149/18367	0.706720468619461	0.816800131066672	CYP20A1/PTGES2/CYP2J2/CYBA	4
GO:0005501	retinoid binding	1/588	38/18367	0.709948290021472	0.816800131066672	NR2F2	1
GO:0008395	steroid hydroxylase activity	1/588	38/18367	0.709948290021472	0.816800131066672	CYP2J2	1
GO:0019840	isoprenoid binding	1/588	38/18367	0.709948290021472	0.816800131066672	NR2F2	1
GO:0140303	intramembrane lipid transporter activity	1/588	38/18367	0.709948290021472	0.816800131066672	ATP10D	1
GO:0005506	iron ion binding	4/588	151/18367	0.716503060489621	0.819206769077202	FTH1/CYP20A1/CYP2J2/RRM2	4
GO:0001221	transcription coregulator binding	2/588	78/18367	0.717747679406159	0.819206769077202	RPL23/VGLL4	2
GO:0030971	receptor tyrosine kinase binding	2/588	78/18367	0.717747679406159	0.819206769077202	EIF3A/PCNA	2
GO:0004402	histone acetyltransferase activity	1/588	39/18367	0.719253238762122	0.819206769077202	NCOA3	1
GO:0005504	fatty acid binding	1/588	39/18367	0.719253238762122	0.819206769077202	S100A9	1
GO:0032451	demethylase activity	1/588	39/18367	0.719253238762122	0.819206769077202	KDM5A	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/588	39/18367	0.719253238762122	0.819206769077202	UBE2L3	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1/588	40/18367	0.728260173267135	0.824739085110217	CYP2J2	1
GO:0042169	SH2 domain binding	1/588	40/18367	0.728260173267135	0.824739085110217	DAG1	1
GO:0042287	MHC protein binding	1/588	40/18367	0.728260173267135	0.824739085110217	CD81	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/588	40/18367	0.728260173267135	0.824739085110217	SERPINB9	1
GO:0008236	serine-type peptidase activity	5/588	191/18367	0.735840293132398	0.828710049286202	CTSC/CTSA/CTSV/DPP4/PRSS8	5
GO:0035591	signaling adaptor activity	2/588	81/18367	0.736973128552362	0.828710049286202	IQGAP1/DLG5	2
GO:0004812	aminoacyl-tRNA ligase activity	1/588	41/18367	0.736978622446975	0.828710049286202	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/588	41/18367	0.736978622446975	0.828710049286202	IARS2	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	1/588	41/18367	0.736978622446975	0.828710049286202	NCOA3	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	2/588	82/18367	0.743128994238471	0.833484050309555	SLC9A1/PFN1	2
GO:0008137	NADH dehydrogenase (ubiquinone) activity	1/588	42/18367	0.745417811031564	0.833484050309555	NDUFB9	1
GO:0019205	nucleobase-containing compound kinase activity	1/588	42/18367	0.745417811031564	0.833484050309555	N4BP2	1
GO:0019894	kinesin binding	1/588	42/18367	0.745417811031564	0.833484050309555	KTN1	1
GO:0017171	serine hydrolase activity	5/588	195/18367	0.752069576219373	0.837904058832246	CTSC/CTSA/CTSV/DPP4/PRSS8	5
GO:0004180	carboxypeptidase activity	1/588	43/18367	0.753586669264221	0.837904058832246	CTSA	1
GO:0030547	signaling receptor inhibitor activity	1/588	43/18367	0.753586669264221	0.837904058832246	LRPAP1	1
GO:0050136	NADH dehydrogenase (quinone) activity	1/588	43/18367	0.753586669264221	0.837904058832246	NDUFB9	1
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/588	44/18367	0.761493842287176	0.841985541889159	GAPDH	1
GO:0022839	ion gated channel activity	1/588	44/18367	0.761493842287176	0.841985541889159	KCNN4	1
GO:0051879	Hsp90 protein binding	1/588	44/18367	0.761493842287176	0.841985541889159	PTGES3	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/588	44/18367	0.761493842287176	0.841985541889159	GABRE	1
GO:0003954	NADH dehydrogenase activity	1/588	45/18367	0.76914769922846	0.846914710369288	NDUFB9	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	1/588	45/18367	0.76914769922846	0.846914710369288	NDUFB9	1
GO:0005245	voltage-gated calcium channel activity	1/588	45/18367	0.76914769922846	0.846914710369288	ITGAV	1
GO:0016887	ATP hydrolysis activity	7/588	272/18367	0.771709619724783	0.848560370236795	ATP2B1/HSPA5/HSPA1A/ATRX/KIF5B/ATP10D/HSPA8	7
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/588	47/18367	0.783727613813641	0.860584879809178	ATP2B1	1
GO:0016298	lipase activity	3/588	129/18367	0.786061748236648	0.861957365307772	PDIA3/PLD3/NOTUM	3
GO:0015078	proton transmembrane transporter activity	3/588	130/18367	0.790414556976566	0.865536601647892	COX6A1/SLC9A1/UQCRH	3
GO:0016407	acetyltransferase activity	2/588	91/18367	0.793160357360554	0.867348671391527	NCOA3/HADHA	2
GO:0034212	peptide N-acetyltransferase activity	1/588	49/18367	0.797388173146263	0.870413981986778	NCOA3	1
GO:0043130	ubiquitin binding	2/588	92/18367	0.798153198576555	0.870413981986778	N4BP2/CKS1B	2
GO:0005048	signal sequence binding	1/588	50/18367	0.803891926513988	0.873079346418881	NFKBIA	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/588	50/18367	0.803891926513988	0.873079346418881	PCNA	1
GO:0030159	signaling receptor complex adaptor activity	1/588	50/18367	0.803891926513988	0.873079346418881	DLG5	1
GO:0008227	G protein-coupled amine receptor activity	1/588	51/18367	0.810187255837009	0.878344880993571	ADRB1	1
GO:0015085	calcium ion transmembrane transporter activity	3/588	135/18367	0.811086663646849	0.878344880993571	ATP2B1/ITGAV/SLC3A2	3
GO:0004252	serine-type endopeptidase activity	4/588	174/18367	0.812054701295943	0.878344880993571	CTSC/CTSV/DPP4/PRSS8	4
GO:0016597	amino acid binding	1/588	52/18367	0.81628082941027	0.880520026297374	GLDC	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/588	52/18367	0.81628082941027	0.880520026297374	AGL	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/588	53/18367	0.822179102536492	0.885680740537278	SLC19A1	1
GO:0008374	O-acyltransferase activity	1/588	54/18367	0.827888324318109	0.890624110734637	CROT	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	1/588	56/18367	0.838763618500724	0.901104157713616	SERPINB9	1
GO:0004497	monooxygenase activity	2/588	102/18367	0.842479897452858	0.903005742820875	CYP20A1/CYP2J2	2
GO:0004536	deoxyribonuclease activity	1/588	57/18367	0.843941216246428	0.903005742820875	PLD3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/588	57/18367	0.843941216246428	0.903005742820875	NDUFB9	1
GO:0031490	chromatin DNA binding	2/588	103/18367	0.846389819303198	0.904408476271562	HMGN3/HNRNPC	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	1/588	58/18367	0.848952825468006	0.905929525163845	GSTO1	1
GO:0052689	carboxylic ester hydrolase activity	3/588	147/18367	0.853756407444847	0.90866665094622	APMAP/NOTUM/IARS2	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/588	59/18367	0.853803758813618	0.90866665094622	PLD3	1
GO:0022824	transmitter-gated ion channel activity	1/588	60/18367	0.858499159175077	0.911224074157792	GABRE	1
GO:0022835	transmitter-gated channel activity	1/588	60/18367	0.858499159175077	0.911224074157792	GABRE	1
GO:0140097	catalytic activity, acting on DNA	5/588	229/18367	0.861005028941347	0.911616590140499	BPTF/ATRX/PLD3/PTGES3/PCNA	5
GO:1902936	phosphatidylinositol bisphosphate binding	2/588	107/18367	0.861162338610711	0.911616590140499	SLC9A1/PFN1	2
GO:0042626	ATPase-coupled transmembrane transporter activity	2/588	109/18367	0.868050861399806	0.917671806440599	ATP2B1/SLC26A2	2
GO:0035091	phosphatidylinositol binding	6/588	271/18367	0.869191031760719	0.917671806440599	IQGAP2/GPAA1/IQGAP1/SLC9A1/PHLDA2/PFN1	6
GO:0005319	lipid transporter activity	3/588	154/18367	0.874556888427894	0.919281493318282	SLC2A1/SLC27A2/ATP10D	3
GO:0008094	ATP-dependent activity, acting on DNA	2/588	111/18367	0.874624371970357	0.919281493318282	BPTF/ATRX	2
GO:0030594	neurotransmitter receptor activity	2/588	111/18367	0.874624371970357	0.919281493318282	GABRE/ADRB1	2
GO:0005125	cytokine activity	5/588	235/18367	0.875340994266591	0.919281493318282	GRN/BMP7/MIF/FAM3B/HMGB1	5
GO:0015079	potassium ion transmembrane transporter activity	3/588	155/18367	0.877304517446515	0.920128088878601	KCNN4/SLC12A9/SLC9A1	3
GO:0008173	RNA methyltransferase activity	1/588	65/18367	0.879811952524761	0.920524904690003	FBL	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	3/588	156/18367	0.879998651024405	0.920524904690003	KMT2C/NSD1/FBL	3
GO:0008080	N-acetyltransferase activity	1/588	68/18367	0.891028435871921	0.930837853506146	NCOA3	1
GO:0106310	protein serine kinase activity	8/588	360/18367	0.893789227902798	0.932496635410399	AAK1/PRKDC/ROCK1/PKN2/CDK6/EIF2AK4/PRKCZ/CDK1	8
GO:0016874	ligase activity	3/588	165/18367	0.901971552505386	0.939799979347028	ACSS1/SLC27A2/IARS2	3
GO:0003678	DNA helicase activity	1/588	72/18367	0.904375019407232	0.940480905029223	ATRX	1
GO:0015267	channel activity	11/588	480/18367	0.904991059556422	0.940480905029223	CLDN4/ITGAV/KCNN4/GABRE/GJA5/GJA1/TMC5/TMEM150C/FXYD3/VDAC1/CLIC3	11
GO:0022803	passive transmembrane transporter activity	11/588	481/18367	0.906326009930492	0.940575590082703	CLDN4/ITGAV/KCNN4/GABRE/GJA5/GJA1/TMC5/TMEM150C/FXYD3/VDAC1/CLIC3	11
GO:0005230	extracellular ligand-gated ion channel activity	1/588	73/18367	0.907448399488595	0.940575590082703	GABRE	1
GO:0008168	methyltransferase activity	4/588	214/18367	0.914891647010387	0.947055806475596	KMT2C/NSD1/TYMS/FBL	4
GO:0022836	gated channel activity	7/588	340/18367	0.921848909489348	0.953016752983136	ITGAV/KCNN4/GABRE/TMC5/TMEM150C/VDAC1/CLIC3	7
GO:0004527	exonuclease activity	1/588	80/18367	0.926370835976503	0.956447811170546	PLD3	1
GO:0005085	guanyl-nucleotide exchange factor activity	4/588	223/18367	0.929584975467208	0.958521472758016	MYCBP2/ADRB1/EEF1B2/NUCB1	4
GO:0016741	transferase activity, transferring one-carbon groups	4/588	225/18367	0.932522458800693	0.960304863661335	KMT2C/NSD1/TYMS/FBL	4
GO:0005126	cytokine receptor binding	5/588	271/18367	0.937441472140487	0.963281619354953	TGFBR3/CSH1/PRLR/IL6ST/MIF	5
GO:0005216	ion channel activity	9/588	432/18367	0.937836444504067	0.963281619354953	CLDN4/ITGAV/KCNN4/GABRE/TMC5/TMEM150C/FXYD3/VDAC1/CLIC3	9
GO:0008528	G protein-coupled peptide receptor activity	2/588	147/18367	0.951547522103156	0.976103587189689	LGR5/LGR4	2
GO:0016410	N-acyltransferase activity	1/588	94/18367	0.953412893568751	0.976756765962832	NCOA3	1
GO:0005244	voltage-gated ion channel activity	3/588	201/18367	0.957979340953876	0.978538568674045	ITGAV/VDAC1/CLIC3	3
GO:0022832	voltage-gated channel activity	3/588	201/18367	0.957979340953876	0.978538568674045	ITGAV/VDAC1/CLIC3	3
GO:0001653	peptide receptor activity	2/588	153/18367	0.958844710688152	0.978538568674045	LGR5/LGR4	2
GO:0016746	acyltransferase activity	4/588	250/18367	0.960940943870693	0.979420577406668	KMT2C/CROT/NCOA3/HADHA	4
GO:0003823	antigen binding	2/588	171/18367	0.974944509721323	0.990743226864894	DHCR24/TSPAN4	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	3/588	222/18367	0.974957935055685	0.990743226864894	CROT/NCOA3/HADHA	3
GO:0101005	deubiquitinase activity	1/588	114/18367	0.975788612119764	0.990743226864894	EIF3H	1
GO:0005262	calcium channel activity	1/588	119/18367	0.979445415406138	0.993106647568153	ITGAV	1
GO:0005267	potassium channel activity	1/588	121/18367	0.980748757457317	0.993106647568153	KCNN4	1
GO:0140101	catalytic activity, acting on a tRNA	1/588	124/18367	0.982550703853063	0.993106647568153	IARS2	1
GO:0019783	ubiquitin-like protein-specific protease activity	1/588	125/18367	0.983113121554889	0.993106647568153	EIF3H	1
GO:0004519	endonuclease activity	1/588	129/18367	0.985187536186677	0.993939202117269	N4BP2	1
GO:0015276	ligand-gated ion channel activity	1/588	143/18367	0.990639478343732	0.995442233458748	GABRE	1
GO:0022834	ligand-gated channel activity	1/588	143/18367	0.990639478343732	0.995442233458748	GABRE	1
GO:0022843	voltage-gated cation channel activity	1/588	143/18367	0.990639478343732	0.995442233458748	ITGAV	1
GO:0004518	nuclease activity	2/588	210/18367	0.991685847672111	0.995442233458748	N4BP2/PLD3	2
GO:0004386	helicase activity	1/588	156/18367	0.99388958040701	0.996396237608541	ATRX	1
GO:0140098	catalytic activity, acting on RNA	4/588	386/18367	0.998576619207571	0.999795140193277	POLR2J3/POLR2A/IARS2/FBL	4
GO:0005261	cation channel activity	2/588	335/18367	0.999795140193277	0.999795140193277	ITGAV/KCNN4	2