ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0003735	structural constituent of ribosome	55/975	182/18367	4.72959648823554e-27	4.37960634810611e-24	RPLP0/RPS3A/RPS13/RPS21/RPL14/RPL19/RPL8/RPL6/RPL18A/RPS10/RPS12/RPS6/RPL23A/RPL24/RPL13/RPS25/RPL26/RPS8/RPLP1/RPL29/RPS26/RPL3/RPS2/RPL10A/RPS16/RPS27A/RPL28/RPL13A/RPL15/RPL21/RPS4X/RPL7A/RPL12/RPL11/RPL10/UBA52/RPS20/RPL9/RPL22/RPL27/RPL7/RPS3/RPS5/RPL17/RPS11/RPL4/RPL27A/RPL35/RPSA/RPL31/RPL36A/RPS4Y1/MRPS6/MRPL51/MRPS15	55
GO:0045296	cadherin binding	73/975	332/18367	6.55239321040699e-26	3.03375805641844e-23	EGFR/AHNAK/ALDOA/LDHA/RPL14/RPL6/KRT18/CD46/CDH1/ITGA6/RPL23A/RPL24/ARGLU1/S100A11/PFN1/HSPA5/RPL29/ITGB1/RPS26/RPS2/RPL15/RPL7A/MACF1/IQGAP1/PKM/ENO1/ANXA1/S100P/CTNND1/PLEC/PRDX6/PRDX1/EFHD2/LRRFIP1/WASF2/ANK3/DLG1/ANXA2/KTN1/PKN2/EPS8L1/ERC1/HSPA1A/RAN/FMNL2/KIF5B/TLN1/SPTBN1/SPTAN1/ARHGAP18/TAGLN2/CLIC1/DNAJB1/DOCK9/LARP1/GAPVD1/PDXDC1/VCL/IDH1/RTN4/EPN2/SLK/SLC3A2/USP8/EIF4H/CALD1/EEF1D/EZR/YWHAE/OLA1/RANBP1/CCT8/CNN3	73
GO:0003712	transcription coregulator activity	62/975	489/18367	1.61433803932173e-10	4.98292341470642e-08	FUS/TLE4/SF1/VGLL1/N4BP2L2/BRD4/TRIP11/DDX17/RERE/KMT2C/CCAR1/NCOA3/MAGED1/NPM1/PTPN14/KDM5A/BCLAF1/MAML2/ZNF451/BTG1/HSPA1A/ARID1A/SMARCA2/KDM5B/TBL1X/BRD7/RCOR1/NCOR1/NSD1/NRIP1/JMJD1C/TCERG1/SRSF2/SAP18/RSF1/DNAJB1/TFAP2A/USP22/KDM2A/PAWR/HMGA1/DNMT3A/EP300/ARID5B/ACTN4/CITED2/MED13/IRF2BP2/BTG2/THRAP3/SIAH2/UBE2L3/ARID3A/TMF1/EDF1/CDYL/XPC/TRIM24/EID1/HNRNPU/UXT/TAF9	62
GO:0140297	DNA-binding transcription factor binding	48/975	394/18367	6.835470915434e-08	1.28395930162444e-05	JUN/FOS/FUS/JUND/TLE4/DDX5/RPS3/HSPB1/ISL1/NCOA3/NPM1/TACC2/PARP1/GTF2I/ARID1A/ANXA4/TBX3/BHLHE41/PURA/NCOR1/NSD1/NRIP1/JMJD1C/TCERG1/CHD4/FOXP1/TCF7L2/HMGA1/MAPK14/EP300/NEK6/ACTN4/RBPJ/BAZ2A/CITED2/MED13/NFKBIA/HMGN3/THRAP3/DDIT3/RXRA/TMF1/REST/TRIM24/KLF5/HES1/SRI/TAF9	48
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	40/975	299/18367	6.93282560272376e-08	1.28395930162444e-05	JUN/FOS/FUS/JUND/DDX5/HSPB1/ISL1/NCOA3/NPM1/TACC2/PARP1/GTF2I/ARID1A/ANXA4/TBX3/BHLHE41/NCOR1/NSD1/NRIP1/JMJD1C/TCERG1/CHD4/FOXP1/TCF7L2/HMGA1/MAPK14/EP300/ACTN4/RBPJ/BAZ2A/CITED2/MED13/NFKBIA/HMGN3/THRAP3/RXRA/TMF1/REST/TRIM24/HES1	40
GO:0003714	transcription corepressor activity	29/975	187/18367	1.94136375068528e-07	2.99617138855761e-05	TLE4/SF1/N4BP2L2/RERE/CCAR1/ZNF451/HSPA1A/KDM5B/TBL1X/BRD7/RCOR1/NCOR1/NSD1/NRIP1/TCERG1/SRSF2/SAP18/DNAJB1/TFAP2A/PAWR/DNMT3A/CITED2/IRF2BP2/BTG2/SIAH2/CDYL/EID1/HNRNPU/UXT	29
GO:0051020	GTPase binding	38/975	291/18367	2.753848180088e-07	3.64294773537356e-05	CAV1/GOLGA4/PFN1/IQGAP2/MYCBP2/IQGAP1/ENO1/RASA1/TRIP11/ROCK1/ANXA2/AKAP13/GCC2/PKN2/RANBP2/PPP1R9A/ERC1/YBX1/CHML/FMNL2/DIAPH1/RABGAP1/SPTBN1/DIAPH2/EXPH5/ABCA1/TNPO1/CLTA/CCDC186/TRIOBP/KPNB1/RAB3GAP2/RHOBTB3/EVI5/XPO1/EPS8/RANBP1/STOML2	38
GO:0016922	nuclear receptor binding	24/975	144/18367	5.68867810612992e-07	6.58464490784539e-05	FUS/JUND/DDX5/ISL1/NCOA3/TACC2/PARP1/ARID1A/NCOR1/NSD1/NRIP1/JMJD1C/FOXP1/TCF7L2/HMGA1/EP300/ACTN4/BAZ2A/MED13/HMGN3/THRAP3/RXRA/TMF1/TRIM24	24
GO:0003779	actin binding	48/975	440/18367	1.79829628013358e-06	0.000175831415367131	EGFR/ALDOA/SYNE2/PFN1/DAG1/IQGAP2/ITGB1/MYH10/UTRN/MACF1/IQGAP1/CFL1/DST/PLEC/WASF2/PHACTR2/ARPC3/TMSB4X/PDLIM2/EPS8L1/PPP1R9A/FMNL2/DIAPH1/TLN1/FERMT1/SCIN/SPTBN1/SPTAN1/RAI14/DIAPH2/SORBS1/SVIL/TRIOBP/DMD/PAWR/VCL/SLC6A4/ACTN4/P4HB/COTL1/EPS8/ADD3/CALD1/TMSB10/TPM4/EZR/HNRNPU/CNN3	48
GO:0044325	transmembrane transporter binding	22/975	133/18367	1.89882737977464e-06	0.000175831415367131	TCAF1/AKAP9/CAV1/S100A10/ANK3/DLG1/PHPT1/PPP1R9A/DIAPH1/SLC5A3/PDE4B/USP10/CALM1/ACTN4/HOMER1/VAMP2/GOPC/YWHAE/VDAC1/CALM2/YWHAQ/SRI	22
GO:0019843	rRNA binding	15/975	68/18367	2.11300268079033e-06	0.000177876407491986	RPLP0/RPS13/RPL19/RPL8/RPL23A/RPS4X/RPL12/RPL11/RPL9/RPS3/RPS5/RPS11/NPM1/RPS4Y1/MRPS6	15
GO:0045182	translation regulator activity	22/975	140/18367	4.54180325331326e-06	0.000350475817714007	EEF1A1/EEF1B2/RPL10/EIF3A/RPL22/EIF2S2/EIF3H/IGF2BP3/PURA/EIF4G1/CELF1/EIF1/EIF3I/LARP1/EIF5A/AGO2/EIF2AK4/EIF3F/PABPC1/EIF4H/EEF1D/EIF4B	22
GO:0005178	integrin binding	22/975	144/18367	7.2589706882492e-06	0.000517062065947597	FBN1/EGFR/ITGB4/LAMB1/ITGAV/LAMA5/ITGB1/UTRN/FBLN1/IGF2/DST/PLPP3/PPIA/JAM3/ITGB8/TLN1/FERMT1/MMP14/ACTN4/P4HB/ITGB5/TIMP2	22
GO:0003713	transcription coactivator activity	32/975	262/18367	9.80823567233817e-06	0.000648744730898939	FUS/VGLL1/BRD4/TRIP11/DDX17/RERE/KMT2C/CCAR1/NCOA3/MAGED1/NPM1/KDM5A/MAML2/ARID1A/SMARCA2/BRD7/NRIP1/TCERG1/USP22/HMGA1/EP300/ARID5B/ACTN4/CITED2/MED13/THRAP3/UBE2L3/TMF1/EDF1/XPC/TRIM24/TAF9	32
GO:0097718	disordered domain specific binding	10/975	36/18367	1.21791495600568e-05	0.000701583207738767	GAPDH/GJA1/NCOA3/CLTC/HSPA1A/CALM1/GJA5/AP2A2/EZR/CALM2	10
GO:0043021	ribonucleoprotein complex binding	22/975	149/18367	1.26883362573694e-05	0.000701583207738767	NEAT1/RPLP1/HSPA5/DDX5/SNRPD2/RPSA/NPM1/NEMF/RICTOR/CSNK2B/RPN2/EIF1/LARP1/CCDC47/EIF5A/EIF4H/SNRPG/HNRNPU/OLA1/EIF4B/SNRPD1/SNRPC	22
GO:0140678	molecular function inhibitor activity	20/975	128/18367	1.32875928642968e-05	0.000701583207738767	CAV1/DYNLL1/RPL11/RPS20/ANXA1/RASA1/ANXA2/OAZ1/PHPT1/ANXA4/PURA/PPP1R12A/CALM1/FAF2/WNK1/TAF3/DDIT3/ID1/ANXA3/CALM2	20
GO:0048306	calcium-dependent protein binding	16/975	88/18367	1.38357255380736e-05	0.000701583207738767	S100A11/DDX5/ANXA1/S100P/S100A10/ANXA2/ANXA4/S100A9/ATP2B4/SEC31A/SLC9A1/CALM1/PDCD6/VAMP2/ANXA3/CALM2	16
GO:0090079	translation regulator activity, nucleic acid binding	18/975	108/18367	1.43953357959358e-05	0.000701583207738767	EEF1A1/EEF1B2/EIF3A/EIF2S2/EIF3H/PURA/EIF4G1/CELF1/EIF1/EIF3I/LARP1/EIF5A/AGO2/EIF3F/PABPC1/EIF4H/EEF1D/EIF4B	18
GO:0031267	small GTPase binding	31/975	259/18367	2.01156799503194e-05	0.00093135598169979	CAV1/GOLGA4/PFN1/IQGAP2/MYCBP2/IQGAP1/TRIP11/ROCK1/ANXA2/AKAP13/GCC2/PKN2/RANBP2/ERC1/CHML/FMNL2/DIAPH1/RABGAP1/DIAPH2/EXPH5/ABCA1/TNPO1/CCDC186/TRIOBP/KPNB1/RAB3GAP2/RHOBTB3/EVI5/XPO1/EPS8/RANBP1	31
GO:0044548	S100 protein binding	6/975	14/18367	4.57863062920994e-05	0.00201895807745162	AHNAK/S100A11/IQGAP1/ANXA2/EZR/CACYBP	6
GO:0003727	single-stranded RNA binding	15/975	87/18367	4.87888259775525e-05	0.00205356603887335	ANXA1/HNRNPDL/MSI2/HNRNPA1/L1TD1/TIA1/RBMS1/AGO2/PABPC1/EIF4H/HNRNPC/HNRNPU/EIF4B/SNRPC/SSB	15
GO:0098631	cell adhesion mediator activity	12/975	59/18367	5.17831819173245e-05	0.00208483593284533	KRT18/S100A11/ITGB1/DSP/ANXA1/BCAM/ANXA2/RPSA/DSG2/JAM3/DSC2/CNN3	12
GO:0003725	double-stranded RNA binding	13/975	74/18367	0.000125759664472472	0.0044916530500039	LRRFIP1/CLTC/TUBA1B/DICER1/TFRC/ADAR/MBNL1/AGO2/TUBB4B/SLC3A2/EIF4H/HNRNPU/EIF4B	13
GO:0046966	thyroid hormone receptor binding	8/975	30/18367	0.00012591309841175	0.0044916530500039	FUS/NCOA3/NCOR1/NSD1/JMJD1C/MED13/HMGN3/THRAP3	8
GO:0008135	translation factor activity, RNA binding	14/975	84/18367	0.000126115528401837	0.0044916530500039	EEF1A1/EEF1B2/EIF3A/EIF2S2/EIF3H/EIF4G1/EIF1/EIF3I/EIF5A/AGO2/EIF3F/EIF4H/EEF1D/EIF4B	14
GO:0050840	extracellular matrix binding	11/975	56/18367	0.00014704258368215	0.00504301601813597	ITGA6/ITGAV/DAG1/ITGB1/ADGRG1/BCAM/ANXA2/RPSA/SMOC1/LGALS3/GPC1	11
GO:0001618	virus receptor activity	13/975	76/18367	0.00016637232361957	0.0055021704168472	EGFR/CD46/ITGAV/DAG1/ITGB1/RPSA/HSPA1A/TFRC/SLC1A5/ITGB5/DPP4/HSPA1B/CDK1	13
GO:0008022	protein C-terminus binding	23/975	189/18367	0.00017755179057752	0.00566941234740631	PRRC2C/FBLN1/DST/BCAM/DLG1/NIPBL/PPP1R9A/HIC2/TBL1X/FOXN3/AGO2/SIAH1/EP300/POLR2A/ATXN2/PABPC1/VAMP2/BANF1/ID1/EZR/YWHAQ/DYNLT1/CDC20	23
GO:0140272	exogenous protein binding	13/975	77/18367	0.000190590676237899	0.00588289887320982	EGFR/CD46/ITGAV/DAG1/ITGB1/RPSA/HSPA1A/TFRC/SLC1A5/ITGB5/DPP4/HSPA1B/CDK1	13
GO:0051015	actin filament binding	25/975	217/18367	0.000226059127844375	0.00675260491560939	EGFR/SYNE2/IQGAP2/MYH10/UTRN/MACF1/IQGAP1/CFL1/ARPC3/PPP1R9A/FMNL2/TLN1/FERMT1/SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/DMD/SLC6A4/ACTN4/COTL1/ADD3/TPM4/EZR	25
GO:0042393	histone binding	27/975	244/18367	0.00025126494417449	0.0072709793220493	BPTF/ATRX/BRD4/KMT2C/MORC4/NPM1/BAZ1B/BRD2/KDM5A/PHIP/SMARCA2/CHD2/CTSL/KDM5B/TBL1X/BRD7/MPHOSPH8/RSF1/CHD8/MTF2/CKS1B/PHF14/SUPT6H/BAZ2A/CDYL/TRIM24/SBNO1	27
GO:0003743	translation initiation factor activity	10/975	51/18367	0.000296800183763095	0.00832839303529171	EIF3A/EIF2S2/EIF3H/EIF4G1/EIF1/EIF3I/AGO2/EIF3F/EIF4H/EIF4B	10
GO:0035198	miRNA binding	8/975	34/18367	0.000323352078825019	0.008806588970352	NEAT1/KCNQ1OT1/SOX4/PUM1/YBX1/HNRNPA1/PUM2/AGO2	8
GO:0005200	structural constituent of cytoskeleton	15/975	103/18367	0.000343078634884343	0.00907688045436863	KRT19/ACTG1/DSP/PLEC/ANK3/ARPC3/TUBA1C/TUBA1B/TLN1/SPTBN1/SPTAN1/DMD/TUBB4B/ADD3/TUBB6	15
GO:0031994	insulin-like growth factor I binding	5/975	13/18367	0.000375399196348886	0.00965610155052968	LRP2/ITGB4/ITGA6/ITGAV/IGF1R	5
GO:0005516	calmodulin binding	23/975	201/18367	0.000436432637052653	0.0109226114029934	EGFR/ATP2B1/IQGAP2/MYH10/IQGAP1/DDX5/EEA1/UBR4/KCNN4/PHKB/ATP2B4/SYT7/SPTBN1/SPTAN1/SLC9A1/CAMSAP2/TRPV6/VAMP2/CAMK2G/EDF1/ADD3/CALD1/CNN3	23
GO:0019838	growth factor binding	18/975	141/18367	0.000486228069431254	0.011848610323509	EGFR/LRP2/NRP2/ITGB4/ITGA6/ITGAV/RPS2/CRIM1/GLG1/TGFBR3/IL6ST/DUSP1/LTBP1/NRP1/IGF1R/LTBP3/GPC1/HTRA1	18
GO:0043236	laminin binding	7/975	28/18367	0.000515063176347704	0.0122294487512301	ITGA6/DAG1/ITGB1/BCAM/RPSA/LGALS3/GPC1	7
GO:0070577	lysine-acetylated histone binding	6/975	21/18367	0.000600521388006471	0.013258501242505	BRD4/BRD2/PHIP/BRD7/BAZ2A/TRIM24	6
GO:0140033	acetylation-dependent protein binding	6/975	21/18367	0.000600521388006471	0.013258501242505	BRD4/BRD2/PHIP/BRD7/BAZ2A/TRIM24	6
GO:0061980	regulatory RNA binding	9/975	46/18367	0.000601357507759406	0.013258501242505	NEAT1/KCNQ1OT1/SOX4/PUM1/YBX1/DICER1/HNRNPA1/PUM2/AGO2	9
GO:0005520	insulin-like growth factor binding	7/975	29/18367	0.00064814370326112	0.0139576992841813	LRP2/ITGB4/ITGA6/ITGAV/CRIM1/IGF1R/HTRA1	7
GO:0047485	protein N-terminus binding	15/975	110/18367	0.000699764857883758	0.0147268695090991	RPS21/SRRM2/NCOA3/NPM1/PARP1/NIPBL/HSPA1A/CALM1/EIF5A/RBPJ/HSPA1B/BANF1/ID1/CALM2/YWHAQ	15
GO:0050998	nitric-oxide synthase binding	5/975	15/18367	0.00080133351487423	0.0164896629949675	CAV1/ATP2B4/DMD/CALM1/SLC6A4	5
GO:0098632	cell-cell adhesion mediator activity	9/975	49/18367	0.000972423713081888	0.0195753121372571	KRT18/S100A11/DSP/ANXA1/ANXA2/DSG2/JAM3/DSC2/CNN3	9
GO:0036002	pre-mRNA binding	10/975	59/18367	0.000994175078025075	0.0195873643032174	SF1/DDX5/TRA2B/HNRNPA1/CELF1/SRSF2/EP300/SRSF6/HNRNPU/SNRPC	10
GO:0043024	ribosomal small subunit binding	5/975	17/18367	0.00151099164158357	0.0286179702846732	NPM1/EIF1/LARP1/EIF4H/EIF4B	5
GO:0044389	ubiquitin-like protein ligase binding	30/975	316/18367	0.00152661902464456	0.0286179702846732	JUN/EGFR/TPI1/HSPA5/RPS27A/ACTG1/RPL11/UBA52/PRDX6/HSPA1A/TUBA1B/HERC2/SMAD5/TRIOBP/PSMD1/VCL/FAF2/POLR2A/NEK6/PCBP2/RTN4/NFKBIA/UBE2C/UBE2L3/HSPA1B/YWHAE/CACYBP/CCNB1/UBE2A/AURKA	30
GO:0070063	RNA polymerase binding	11/975	73/18367	0.0015452467756303	0.0286179702846732	BRD4/NCOA3/PABPN1/PKN2/TCERG1/ZNF326/PCF11/WAC/AGO2/RTF1/HNRNPU	11
GO:0017022	myosin binding	11/975	74/18367	0.00172979024547013	0.0314075640648106	FUS/MYL12B/RAB11A/RHOA/RAB6A/TRIOBP/DMD/ARFGEF1/VAMP2/CALD1/RAB25	11
GO:0002162	dystroglycan binding	4/975	11/18367	0.00192832075924305	0.0330671300566493	DAG1/PLEC/DMD/VCL	4
GO:0046975	histone methyltransferase activity (H3-K36 specific)	4/975	11/18367	0.00192832075924305	0.0330671300566493	ASH1L/SETD2/NSD1/SETD5	4
GO:0097493	structural molecule activity conferring elasticity	4/975	11/18367	0.00192832075924305	0.0330671300566493	FBN1/FBN2/AHNAK/LAMC1	4
GO:0055102	lipase inhibitor activity	5/975	18/18367	0.00200152137335605	0.033096585566566	ANXA1/ANXA2/ANXA4/FAF2/ANXA3	5
GO:0098641	cadherin binding involved in cell-cell adhesion	5/975	18/18367	0.00200152137335605	0.033096585566566	KRT18/S100A11/ANXA1/ANXA2/CNN3	5
GO:0031625	ubiquitin protein ligase binding	28/975	297/18367	0.00238154323354449	0.0381494212142628	JUN/EGFR/TPI1/HSPA5/RPS27A/ACTG1/RPL11/UBA52/PRDX6/HSPA1A/TUBA1B/HERC2/SMAD5/TRIOBP/PSMD1/VCL/FAF2/POLR2A/NEK6/PCBP2/RTN4/NFKBIA/UBE2L3/HSPA1B/YWHAE/CACYBP/UBE2A/AURKA	28
GO:0002039	p53 binding	10/975	66/18367	0.00238948858577456	0.0381494212142628	BRD4/BRD7/USP10/CHD8/EP300/MDM4/TAF3/TRIM24/PTTG1IP/TAF9	10
GO:0048027	mRNA 5'-UTR binding	6/975	27/18367	0.00249399592098253	0.0391430546242343	RPS3A/RPS13/RPL26/MYH10/IGF2BP3/LARP1	6
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	4/975	12/18367	0.00277170553561144	0.0413967633221966	BRD4/CDK6/CDK12/CDK1	4
GO:0017154	semaphorin receptor activity	4/975	12/18367	0.00277170553561144	0.0413967633221966	NRP2/MET/NRP1/PLXNB1	4
GO:0017166	vinculin binding	4/975	12/18367	0.00277170553561144	0.0413967633221966	DAG1/UTRN/TLN1/DMD	4
GO:0046332	SMAD binding	11/975	79/18367	0.00294135204798183	0.0432186260359771	JUN/FOS/DDX5/TGFBR3/PARP1/USP9X/PURA/TRIM33/SMAD5/YY1/CITED2	11
GO:0042826	histone deacetylase binding	15/975	127/18367	0.00301468539907528	0.0432186260359771	PARP1/PKN2/NIPBL/HSPA1A/GLI3/BHLHE41/NCOR1/NRIP1/CHD4/HSPA1B/SFPQ/YWHAE/HES1/CDC20/KPNA2	15
GO:0008187	poly-pyrimidine tract binding	6/975	28/18367	0.00303370485133749	0.0432186260359771	MSI2/RBMS1/PABPC1/HNRNPC/HNRNPU/SSB	6
GO:0004857	enzyme inhibitor activity	10/975	70/18367	0.00371369961961618	0.0521043310267361	DYNLL1/RPL11/RPS20/ANXA1/ANXA2/OAZ1/ANXA4/PPP1R12A/FAF2/ANXA3	10
GO:0004859	phospholipase inhibitor activity	4/975	13/18367	0.00383673057528368	0.0530270524285476	ANXA1/ANXA2/ANXA4/ANXA3	4
GO:0043539	protein serine/threonine kinase activator activity	8/975	49/18367	0.00397493813396672	0.0541293045890175	IQGAP1/IGF2/RICTOR/TAOK1/CALM1/CKS1B/CALM2/CCNB1	8
GO:0000993	RNA polymerase II complex binding	8/975	50/18367	0.00451665487073643	0.0606148175406077	BRD4/NCOA3/ZNF326/PCF11/WAC/AGO2/RTF1/HNRNPU	8
GO:0004177	aminopeptidase activity	7/975	40/18367	0.00465895331599338	0.0607632502902798	ENPEP/CTSV/MMP14/MMP15/NPEPPS/DPP4/DPP7	7
GO:0044183	protein folding chaperone	7/975	40/18367	0.00465895331599338	0.0607632502902798	HSPA5/HSPB1/HSPA1A/DNAJB1/CCDC47/HSPA1B/CCT8	7
GO:0051018	protein kinase A binding	8/975	51/18367	0.00511330389692725	0.0643234077234538	AKAP9/RPS3/WASF2/AKAP13/CRYBG3/ARFGEF1/EZR/ACBD3	8
GO:0004602	glutathione peroxidase activity	5/975	22/18367	0.00515656727643468	0.0643234077234538	GPX3/PRDX6/GPX4/GSTP1/GPX1	5
GO:0140142	nucleocytoplasmic carrier activity	6/975	31/18367	0.00517777826230349	0.0643234077234538	RAN/TNPO1/KPNB1/XPO1/KPNA6/KPNA2	6
GO:0008013	beta-catenin binding	11/975	85/18367	0.0052097792432603	0.0643234077234538	CDH1/KANK1/DLG5/GJA1/SKP1/GLI3/TBL1X/TCF7L2/CHD8/VCL/EP300	11
GO:0051082	unfolded protein binding	14/975	122/18367	0.00528906917672776	0.0644431323374988	HSP90B1/NACA/HSPA5/LMAN1/NPM1/PPIA/PTGES3/HSPA1A/DNAJB1/TUBB4B/SERPINH1/HSPA1B/AFG3L2/CCT8	14
GO:0002020	protease binding	15/975	135/18367	0.00537531114311941	0.0646433521886828	LRP1/ADAMTSL4/ITGAV/ITGB1/SERPINB9/ANXA2/PSAP/CLTC/CFLAR/FLOT2/DPP4/SERPINB6/CSTB/SRI/TIMP2	15
GO:0008234	cysteine-type peptidase activity	19/975	190/18367	0.00602435631427006	0.0686944962310587	CTSC/EIF3H/USP34/USP47/CTSL/USP9X/CTSD/CTSV/USP22/USP10/USP27X/PDIA3/USP48/CFLAR/EIF3F/USP8/GGH/UCHL3/CASP4	19
GO:0140658	ATP-dependent chromatin remodeler activity	6/975	32/18367	0.0060919649478485	0.0686944962310587	ATRX/SMARCA2/CHD2/CHD4/CHD8/CHD6	6
GO:0001046	core promoter sequence-specific DNA binding	7/975	42/18367	0.00615071043250117	0.0686944962310587	FOS/NPM1/NR3C1/FOXP1/AGO2/BAZ2A/REST	7
GO:0008307	structural constituent of muscle	7/975	42/18367	0.00615071043250117	0.0686944962310587	KRT19/DAG1/PLEC/MYL6/ASPH/DMD/TPM4	7
GO:0005158	insulin receptor binding	5/975	23/18367	0.00630565030198703	0.0686944962310587	IGF2/IGF1R/PHIP/PIK3R1/SORBS1	5
GO:0008143	poly(A) binding	5/975	23/18367	0.00630565030198703	0.0686944962310587	HNRNPDL/TIA1/RBMS1/PABPC1/HNRNPU	5
GO:0017134	fibroblast growth factor binding	5/975	23/18367	0.00630565030198703	0.0686944962310587	ITGAV/RPS2/GLG1/TGFBR3/GPC1	5
GO:0070412	R-SMAD binding	5/975	23/18367	0.00630565030198703	0.0686944962310587	JUN/FOS/DDX5/PARP1/TRIM33	5
GO:0008200	ion channel inhibitor activity	6/975	33/18367	0.00711818379946319	0.0766446302128246	CAV1/RASA1/PHPT1/CALM1/WNK1/CALM2	6
GO:0016248	channel inhibitor activity	6/975	34/18367	0.00826373223761778	0.0872172468346586	CAV1/RASA1/PHPT1/CALM1/WNK1/CALM2	6
GO:0030674	protein-macromolecule adaptor activity	26/975	296/18367	0.00831969683016305	0.0872172468346586	COL14A1/SYNE2/CAV1/IQGAP1/DLG5/DDB1/CUX1/ANK3/AKAP13/SKP1/FRMD4A/RAD50/SLC9A1/PIK3R1/SORBS1/STON1/HOMER1/SPAG9/PDCD6/EPS8/OBSL1/AP2A2/VAMP2/CDYL/CAV2/VAMP3	26
GO:0008238	exopeptidase activity	12/975	103/18367	0.0083826511536551	0.0872172468346586	ENPEP/CTSC/TFRC/CPD/CTSV/MMP14/MMP15/MME/NPEPPS/DPP4/DPP7/GGH	12
GO:0097110	scaffold protein binding	9/975	67/18367	0.00865802745738644	0.0889001001569054	KRT8/KRT18/DYNLL1/DSP/IL6ST/PSAP/ATP2B4/YWHAE/CAV2	9
GO:0004386	helicase activity	16/975	156/18367	0.00883568258407823	0.0889001001569054	ATRX/DDX5/ANXA1/DDX17/SMARCA2/CHD2/HELZ/RAD50/DICER1/CHD4/DDX39B/CHD8/SETX/CHD6/DDX46/DDX24	16
GO:0030374	nuclear receptor coactivator activity	8/975	56/18367	0.00904358476764212	0.0889001001569054	CCAR1/NCOA3/USP22/HMGA1/ACTN4/MED13/THRAP3/TMF1	8
GO:0008266	poly(U) RNA binding	5/975	25/18367	0.0091204206424471	0.0889001001569054	MSI2/RBMS1/PABPC1/HNRNPC/SSB	5
GO:0034237	protein kinase A regulatory subunit binding	5/975	25/18367	0.0091204206424471	0.0889001001569054	AKAP9/WASF2/ARFGEF1/EZR/ACBD3	5
GO:0051019	mitogen-activated protein kinase binding	5/975	25/18367	0.0091204206424471	0.0889001001569054	IQGAP1/DUSP1/TPR/MAPK14/PRMT1	5
GO:0043175	RNA polymerase core enzyme binding	8/975	57/18367	0.0100440399752633	0.0968831355947277	BRD4/NCOA3/ZNF326/PCF11/WAC/AGO2/RTF1/HNRNPU	8
GO:0004197	cysteine-type endopeptidase activity	13/975	119/18367	0.010518678650654	0.0990974669015375	CTSC/USP34/USP47/CTSL/USP9X/CTSD/CTSV/USP10/PDIA3/USP48/CFLAR/USP8/CASP4	13
GO:0030275	LRR domain binding	4/975	17/18367	0.0107810437301777	0.0990974669015375	ERC1/PAWR/DDIT3/KRAS	4
GO:0031489	myosin V binding	4/975	17/18367	0.0107810437301777	0.0990974669015375	FUS/RAB11A/RAB6A/RAB25	4
GO:0046965	retinoid X receptor binding	4/975	17/18367	0.0107810437301777	0.0990974669015375	FUS/NSD1/NRIP1/HMGA1	4
GO:0042974	retinoic acid receptor binding	5/975	26/18367	0.0108086869946601	0.0990974669015375	FUS/NSD1/NRIP1/HMGA1/ACTN4	5
GO:0001098	basal transcription machinery binding	9/975	70/18367	0.0114434900458223	0.102880308567296	BRD4/NCOA3/ZNF326/PCF11/WAC/AGO2/RTF1/EDF1/HNRNPU	9
GO:0001099	basal RNA polymerase II transcription machinery binding	9/975	70/18367	0.0114434900458223	0.102880308567296	BRD4/NCOA3/ZNF326/PCF11/WAC/AGO2/RTF1/EDF1/HNRNPU	9
GO:0008139	nuclear localization sequence binding	5/975	27/18367	0.012698389511405	0.113064506611164	TNPO1/KPNB1/NFKBIA/KPNA6/KPNA2	5
GO:0008239	dipeptidyl-peptidase activity	3/975	10/18367	0.0135116884771766	0.119160224093957	CTSC/DPP4/DPP7	3
GO:0060090	molecular adaptor activity	30/975	369/18367	0.0137187117507026	0.119844595105195	COL14A1/AKAP9/SYNE2/CAV1/IQGAP1/DLG5/DDB1/CUX1/ANK3/DLG1/AKAP13/SKP1/FRMD4A/RAD50/RB1CC1/EIF4G1/SLC9A1/PIK3R1/SORBS1/STON1/HOMER1/SPAG9/PDCD6/EPS8/OBSL1/AP2A2/VAMP2/CDYL/CAV2/VAMP3	30
GO:0005096	GTPase activator activity	36/975	462/18367	0.0138918815190994	0.120223198940991	JUN/IQGAP2/EEF1B2/MYCBP2/IQGAP1/RASA1/DOCK8/AKAP13/NRP1/ADRB1/RANBP2/EPS8L1/ARHGAP21/DENND4C/CHML/SYDE2/GNAQ/NF1/RABGAP1/ARHGAP5/ARHGAP32/ARHGAP18/FAM13A/HERC2/HACD3/PLXNB1/DOCK9/GAPVD1/RAB3GAP2/ARHGAP23/EVI5/ARFGEF1/EEF1D/ARF4/NUCB2/RANBP1	36
GO:0001968	fibronectin binding	5/975	28/18367	0.0147994079157675	0.12572708009175	ITGAV/CCDC80/ITGB1/FBLN1/CTSL	5
GO:0050681	androgen receptor binding	5/975	28/18367	0.0147994079157675	0.12572708009175	DDX5/NSD1/FOXP1/EP300/TMF1	5
GO:0008201	heparin binding	16/975	166/18367	0.0154113608604763	0.129715737459893	FBN1/APLP2/NRP2/CCDC80/APP/RPL29/ADGRG1/ADAMTS1/RPL22/TGFBR3/NRP1/PTPRF/SMOC1/SOD3/LRPAP1/BMP7	16
GO:0016209	antioxidant activity	10/975	86/18367	0.0155490786803975	0.129715737459893	GPX3/GSTO1/PRDX6/PRDX1/GPX4/GSTP1/GPX1/S100A9/TXN/SOD3	10
GO:0003746	translation elongation factor activity	4/975	19/18367	0.0161403097570618	0.133445775312851	EEF1A1/EEF1B2/EIF5A/EEF1D	4
GO:0032452	histone demethylase activity	5/975	29/18367	0.017120945991795	0.137860834681758	KDM5A/KDM5B/JARID2/JMJD1C/KDM2A	5
GO:0070717	poly-purine tract binding	5/975	29/18367	0.017120945991795	0.137860834681758	HNRNPDL/TIA1/RBMS1/PABPC1/HNRNPU	5
GO:0140457	protein demethylase activity	5/975	29/18367	0.017120945991795	0.137860834681758	KDM5A/KDM5B/JARID2/JMJD1C/KDM2A	5
GO:0005078	MAP-kinase scaffold activity	3/975	11/18367	0.0178554513714016	0.138942419915277	IQGAP1/AKAP13/SPAG9	3
GO:0019855	calcium channel inhibitor activity	3/975	11/18367	0.0178554513714016	0.138942419915277	PHPT1/CALM1/CALM2	3
GO:0043522	leucine zipper domain binding	3/975	11/18367	0.0178554513714016	0.138942419915277	ERC1/PAWR/DDIT3	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	3/975	11/18367	0.0178554513714016	0.138942419915277	DSP/DSG2/DSC2	3
GO:0030295	protein kinase activator activity	11/975	101/18367	0.0181260413456929	0.13987261905093	RPLP1/IQGAP1/IGF2/RICTOR/TAOK1/CALM1/WNK1/CKS1B/CD24/CALM2/CCNB1	11
GO:0061608	nuclear import signal receptor activity	4/975	20/18367	0.0193465139000048	0.148056792325656	TNPO1/KPNB1/KPNA6/KPNA2	4
GO:0005539	glycosaminoglycan binding	20/975	230/18367	0.0209104121911824	0.157423103162885	FBN1/APLP2/NRP2/CCDC80/APP/RPL29/ADGRG1/ADAMTS1/RPL22/TGFBR3/EXTL2/NRP1/PPIA/PTPRF/GNS/SMOC1/SOD3/LRPAP1/BMP7/HMMR	20
GO:0061134	peptidase regulator activity	20/975	230/18367	0.0209104121911824	0.157423103162885	GAPDH/ITIH5/APLP2/CAV1/APP/CRIM1/FBLN1/SPINT1/SERPINB9/CTSC/ROCK1/ANXA2/BIRC6/SERPINB1/SERPINH1/PSME2/SERPINB6/CSTB/TIMP2/PTTG1	20
GO:0000340	RNA 7-methylguanosine cap binding	3/975	12/18367	0.0228833666499984	0.168435640843055	NCBP3/LARP1/AGO2	3
GO:0045295	gamma-catenin binding	3/975	12/18367	0.0228833666499984	0.168435640843055	CDH1/DSC3/TCF7L2	3
GO:0140416	transcription regulator inhibitor activity	4/975	21/18367	0.0229188884948433	0.168435640843055	PURA/TAF3/DDIT3/ID1	4
GO:0140030	modification-dependent protein binding	15/975	160/18367	0.0232636129729309	0.1691232348881	BPTF/ATRX/BRD4/AGL/MORC4/BRD2/KDM5A/PHIP/BRD7/MPHOSPH8/CHD8/MTF2/BAZ2A/CDYL/TRIM24	15
GO:0015459	potassium channel regulator activity	7/975	54/18367	0.0233777257728691	0.1691232348881	AKAP9/CAV1/RASA1/DLG1/SLC5A3/WNK1/YWHAE	7
GO:0019207	kinase regulator activity	20/975	233/18367	0.0236515594337026	0.169777860741152	RPLP1/CCNL1/IQGAP1/IGF2/HSPB1/NPM1/GSTP1/KIDINS220/RICTOR/CSNK2B/PIK3R1/TAOK3/TAOK1/CALM1/WNK1/CKS1B/CD24/CALM2/CCNB1/CCNE1	20
GO:0004674	protein serine/threonine kinase activity	30/975	386/18367	0.0239140607514239	0.170341694275527	EGFR/AAK1/PRKDC/BRD4/TGFBR3/CDK6/ROCK1/AKAP13/LTBP1/PKN2/BRD2/MAP3K4/NRK/CSNK2B/RPS6KA5/LATS2/SMG1/TAOK3/TAOK1/MAST4/CDK12/MAPK14/WNK1/EIF2AK4/NEK6/SLK/STK17A/CAMK2G/CDK1/AURKA	30
GO:0019887	protein kinase regulator activity	18/975	204/18367	0.024118370769302	0.170485582689875	RPLP1/CCNL1/IQGAP1/IGF2/HSPB1/NPM1/KIDINS220/RICTOR/CSNK2B/TAOK3/TAOK1/CALM1/WNK1/CKS1B/CD24/CALM2/CCNB1/CCNE1	18
GO:1901681	sulfur compound binding	22/975	265/18367	0.0256192956522205	0.179723240711789	FBN1/APLP2/NRP2/LRP1/CCDC80/APP/RPL29/ADGRG1/ADAMTS1/RPL22/TGFBR3/GSTP1/NRP1/PPIA/PTPRF/SMOC1/SOD3/LRPAP1/BMP7/HADHA/ACBD3/PRMT1	22
GO:0019209	kinase activator activity	11/975	107/18367	0.0266127143806962	0.182926336284736	RPLP1/IQGAP1/IGF2/RICTOR/TAOK1/CALM1/WNK1/CKS1B/CD24/CALM2/CCNB1	11
GO:0055106	ubiquitin-protein transferase regulator activity	4/975	22/18367	0.026866070987823	0.182926336284736	RPL11/RPS20/UBE2L3/CDC20	4
GO:0070034	telomerase RNA binding	4/975	22/18367	0.026866070987823	0.182926336284736	HNRNPC/HNRNPU/NHP2/NOP10	4
GO:0072349	modified amino acid transmembrane transporter activity	4/975	22/18367	0.026866070987823	0.182926336284736	GJA1/SLC16A12/SLC19A1/SLC13A3	4
GO:0072542	protein phosphatase activator activity	3/975	13/18367	0.0285973574724128	0.191198046780175	PPP1R15A/CALM1/CALM2	3
GO:0019903	protein phosphatase binding	14/975	150/18367	0.0286568468190511	0.191198046780175	EGFR/HSP90B1/MET/BOD1L1/IQGAP1/PPP1R15A/PPP1R9A/KCNN4/ATP2B4/SLC9A1/PIK3R1/PPP6R2/LGALS3/MAPK14	14
GO:0031369	translation initiation factor binding	5/975	33/18367	0.0287702302583563	0.191198046780175	EIF2S2/EIF4G1/CELF1/LARP1/EIF3F	5
GO:0030695	GTPase regulator activity	36/975	488/18367	0.0291133094989251	0.191198046780175	JUN/IQGAP2/EEF1B2/MYCBP2/IQGAP1/RASA1/DOCK8/AKAP13/NRP1/ADRB1/RANBP2/EPS8L1/ARHGAP21/DENND4C/CHML/SYDE2/GNAQ/NF1/RABGAP1/ARHGAP5/ARHGAP32/ARHGAP18/FAM13A/HERC2/HACD3/PLXNB1/DOCK9/GAPVD1/RAB3GAP2/ARHGAP23/EVI5/ARFGEF1/EEF1D/ARF4/NUCB2/RANBP1	36
GO:0060589	nucleoside-triphosphatase regulator activity	36/975	488/18367	0.0291133094989251	0.191198046780175	JUN/IQGAP2/EEF1B2/MYCBP2/IQGAP1/RASA1/DOCK8/AKAP13/NRP1/ADRB1/RANBP2/EPS8L1/ARHGAP21/DENND4C/CHML/SYDE2/GNAQ/NF1/RABGAP1/ARHGAP5/ARHGAP32/ARHGAP18/FAM13A/HERC2/HACD3/PLXNB1/DOCK9/GAPVD1/RAB3GAP2/ARHGAP23/EVI5/ARFGEF1/EEF1D/ARF4/NUCB2/RANBP1	36
GO:0061135	endopeptidase regulator activity	17/975	194/18367	0.0294825459702056	0.192259419495848	GAPDH/ITIH5/APLP2/APP/CRIM1/SPINT1/SERPINB9/ROCK1/ANXA2/BIRC6/SERPINB1/SERPINH1/PSME2/SERPINB6/CSTB/TIMP2/PTTG1	17
GO:0004866	endopeptidase inhibitor activity	16/975	180/18367	0.0303102830254331	0.196274979591266	GAPDH/ITIH5/APLP2/APP/CRIM1/SPINT1/SERPINB9/ROCK1/ANXA2/BIRC6/SERPINB1/SERPINH1/SERPINB6/CSTB/TIMP2/PTTG1	16
GO:0019902	phosphatase binding	17/975	196/18367	0.0320951651848493	0.206311735836841	EGFR/HSP90B1/MET/BOD1L1/IQGAP1/PPP1R15A/CTSC/DLG1/PPP1R9A/KCNN4/ATP2B4/SLC9A1/PIK3R1/PPP6R2/LGALS3/MAPK14/WNK1	17
GO:0045505	dynein intermediate chain binding	5/975	34/18367	0.0323058333653801	0.206311735836841	DYNLL1/DYNC1H1/DYNLRB1/HOOK3/DYNLT1	5
GO:0030165	PDZ domain binding	9/975	84/18367	0.0337923161702638	0.214326608038796	ATP2B1/CRIM1/GJA1/TGFBR3/ADRB1/KIDINS220/CADM1/ERC1/ATP2B4	9
GO:0015926	glucosidase activity	3/975	14/18367	0.0349926324690828	0.216423870408998	GANAB/AGL/GAA	3
GO:0043023	ribosomal large subunit binding	3/975	14/18367	0.0349926324690828	0.216423870408998	NPM1/NEMF/OLA1	3
GO:0140666	annealing activity	3/975	14/18367	0.0349926324690828	0.216423870408998	ANXA1/EIF4H/EIF4B	3
GO:0004867	serine-type endopeptidase inhibitor activity	10/975	98/18367	0.0350578623772675	0.216423870408998	ITIH5/APLP2/APP/CRIM1/SPINT1/SERPINB9/ANXA2/SERPINB1/SERPINH1/SERPINB6	10
GO:0009055	electron transfer activity	12/975	126/18367	0.0356738266252656	0.216742204734172	GLDC/COX6A1/CYP19A1/UQCRH/ASPH/COX5A/AKR1B1/COX7B/ETFA/NDUFA13/NDUFA6/SDHC	12
GO:0003707	steroid hormone receptor activity	4/975	24/18367	0.0359088783181677	0.216742204734172	ESRRG/NR3C1/ESRRA/RXRA	4
GO:0050431	transforming growth factor beta binding	4/975	24/18367	0.0359088783181677	0.216742204734172	ITGAV/TGFBR3/LTBP1/LTBP3	4
GO:0033218	amide binding	30/975	400/18367	0.0361126010608833	0.216742204734172	LRP1/NKTR/ENPEP/PSAP/PPIA/IGF1R/PRLR/DHCR24/PPIG/PIK3R1/SLC40A1/TNPO1/CTSV/CLTA/LRPAP1/KPNB1/CLSTN1/MME/NFKBIA/NPEPPS/RXRA/KPNA6/HADHA/SLC19A1/CLTB/VDAC1/ACBD3/VDAC2/KDELR2/KPNA2	30
GO:0003678	DNA helicase activity	8/975	72/18367	0.0365138055491693	0.216742204734172	ATRX/ANXA1/CHD2/RAD50/CHD4/CHD8/SETX/CHD6	8
GO:0030276	clathrin binding	8/975	72/18367	0.0365138055491693	0.216742204734172	LRP1/CLTC/SYT7/STON1/CLTA/EPN2/AP2A2/CLTB	8
GO:0035064	methylated histone binding	8/975	73/18367	0.039180140402674	0.228181195049535	BPTF/ATRX/MORC4/KDM5A/MPHOSPH8/CHD8/MTF2/CDYL	8
GO:0140034	methylation-dependent protein binding	8/975	73/18367	0.039180140402674	0.228181195049535	BPTF/ATRX/MORC4/KDM5A/MPHOSPH8/CHD8/MTF2/CDYL	8
GO:0140104	molecular carrier activity	8/975	73/18367	0.039180140402674	0.228181195049535	RAN/EMC1/TNPO1/KPNB1/XPO1/EMC10/KPNA6/KPNA2	8
GO:0101005	deubiquitinase activity	11/975	114/18367	0.0397610704595448	0.230117195284616	EIF3H/USP34/USP47/USP9X/USP22/USP10/USP27X/USP48/EIF3F/USP8/UCHL3	11
GO:0042162	telomeric DNA binding	5/975	36/18367	0.0401588070438063	0.230975498897917	RAD50/PURA/HNRNPA1/UPF2/SMG1	5
GO:0015026	coreceptor activity	6/975	48/18367	0.0404473469231712	0.231199032412694	LRP1/ITGAV/ITGB1/TGFBR3/LRP5/NRP1	6
GO:0030414	peptidase inhibitor activity	16/975	187/18367	0.0408727934557116	0.231564603660267	GAPDH/ITIH5/APLP2/APP/CRIM1/SPINT1/SERPINB9/ROCK1/ANXA2/BIRC6/SERPINB1/SERPINH1/SERPINB6/CSTB/TIMP2/PTTG1	16
GO:0035035	histone acetyltransferase binding	4/975	25/18367	0.0410114416849716	0.231564603660267	EGR1/GLI3/CITED2/EID1	4
GO:0005545	1-phosphatidylinositol binding	3/975	15/18367	0.0420586336952207	0.233211346118409	EEA1/ZFYVE16/SCIN	3
GO:0032794	GTPase activating protein binding	3/975	15/18367	0.0420586336952207	0.233211346118409	CDH1/PLXNB1/GAPVD1	3
GO:0042809	vitamin D receptor binding	3/975	15/18367	0.0420586336952207	0.233211346118409	MED13/THRAP3/RXRA	3
GO:0015631	tubulin binding	28/975	375/18367	0.0437741468932007	0.241278928708951	GAPDH/ALDOA/DAG1/CLIP1/MACF1/GJA1/DST/RPS3/CEP350/TPR/SETD2/KIF5B/S100A9/RABGAP1/HOOK2/RAB11A/PDE4B/CAMSAP2/EML4/TAOK1/HOOK3/EZR/CAPN6/CACYBP/NUSAP1/UXT/STMN1/CNN3	28
GO:1990841	promoter-specific chromatin binding	7/975	62/18367	0.0452837215712599	0.248122640088679	DDX5/ISL1/EGR1/NIPBL/ZNF609/POLR2A/HNRNPU	7
GO:0019888	protein phosphatase regulator activity	9/975	89/18367	0.0463356972856537	0.252393268744208	BOD1L1/PPP1R10/PPP1R15A/PHACTR2/PPP1R14B/PPP6R2/LGALS3/CALM1/CALM2	9
GO:0005048	signal sequence binding	6/975	50/18367	0.0479651232160212	0.259740959637635	TNPO1/KPNB1/NFKBIA/KPNA6/KDELR2/KPNA2	6
GO:0015923	mannosidase activity	3/975	16/18367	0.0497798903163985	0.264920565706811	MANBA/MAN2A1/MAN1A2	3
GO:0017070	U6 snRNA binding	3/975	16/18367	0.0497798903163985	0.264920565706811	DDX39B/EIF5A/LSM3	3
GO:0035173	histone kinase activity	3/975	16/18367	0.0497798903163985	0.264920565706811	BAZ1B/CDK1/AURKA	3
GO:0004601	peroxidase activity	6/975	51/18367	0.0520260743389684	0.274043100385564	GPX3/PRDX6/PRDX1/GPX4/GSTP1/GPX1	6
GO:0051959	dynein light intermediate chain binding	4/975	27/18367	0.0523818885186229	0.274043100385564	DYNLL1/DYNC1H1/HOOK2/HOOK3	4
GO:0070006	metalloaminopeptidase activity	4/975	27/18367	0.0523818885186229	0.274043100385564	ENPEP/MMP14/MMP15/NPEPPS	4
GO:0032451	demethylase activity	5/975	39/18367	0.0539334007904007	0.279007425317939	KDM5A/KDM5B/JARID2/JMJD1C/KDM2A	5
GO:0061650	ubiquitin-like protein conjugating enzyme activity	5/975	39/18367	0.0539334007904007	0.279007425317939	BIRC6/UBE2C/UBE2L3/UFC1/UBE2A	5
GO:0016887	ATP hydrolysis activity	21/975	272/18367	0.0551861005351662	0.283901828308688	ATP2B1/HSPA5/ATRX/DDX5/DDX17/HSPA1A/KIF5B/CHD2/ATP2B4/ATP13A3/RNF213/CHD4/ATP10D/DDX39B/CHD8/RHOBTB3/CHD6/DDX46/HSPA1B/DDX24/OLA1	21
GO:0004879	nuclear receptor activity	6/975	52/18367	0.0562902378591241	0.286399781634884	NR2F2/ESRRG/NR3C1/ESRRA/NR2F6/RXRA	6
GO:0098531	ligand-activated transcription factor activity	6/975	52/18367	0.0562902378591241	0.286399781634884	NR2F2/ESRRG/NR3C1/ESRRA/NR2F6/RXRA	6
GO:0042277	peptide binding	24/975	321/18367	0.0577350076813739	0.289433676604574	LRP1/NKTR/ENPEP/PPIA/IGF1R/PRLR/DHCR24/PPIG/PIK3R1/SLC40A1/TNPO1/CTSV/CLTA/LRPAP1/KPNB1/CLSTN1/MME/NFKBIA/NPEPPS/RXRA/KPNA6/CLTB/KDELR2/KPNA2	24
GO:0019208	phosphatase regulator activity	10/975	107/18367	0.0579017439934285	0.289433676604574	BOD1L1/PPP1R10/PPP1R15A/PHACTR2/PPP1R14B/PPP1R12A/PPP6R2/LGALS3/CALM1/CALM2	10
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/975	17/18367	0.0581367860134458	0.289433676604574	PTPRF/PTPRA/PTPRE	3
GO:0019198	transmembrane receptor protein phosphatase activity	3/975	17/18367	0.0581367860134458	0.289433676604574	PTPRF/PTPRA/PTPRE	3
GO:0070325	lipoprotein particle receptor binding	4/975	28/18367	0.0586456352857654	0.29040565922256	LRP1/HSP90B1/CLTC/LRPAP1	4
GO:0043022	ribosome binding	7/975	66/18367	0.0599707884329654	0.295388032387904	HSPA5/RPSA/RICTOR/RPN2/CCDC47/EIF5A/OLA1	7
GO:0030331	estrogen receptor binding	5/975	41/18367	0.0644587869029564	0.31556834261381	FUS/ISL1/PARP1/NSD1/NRIP1	5
GO:0035591	signaling adaptor activity	8/975	81/18367	0.0652123112071327	0.31556834261381	IQGAP1/DLG5/AKAP13/PIK3R1/SORBS1/HOMER1/SPAG9/EPS8	8
GO:0051059	NF-kappaB binding	4/975	29/18367	0.0652895855728006	0.31556834261381	NPM1/ANXA4/EP300/NFKBIA	4
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	6/975	54/18367	0.0654310170430362	0.31556834261381	TET2/KDM5A/KDM5B/ASPH/KDM2A/P4HB	6
GO:0001216	DNA-binding transcription activator activity	32/975	456/18367	0.0658089269446911	0.315746457776083	JUN/FOS/JUND/FOSB/NFAT5/PBX1/SOX4/ISL1/EGR1/GTF2I/TBX3/ZNF292/EPAS1/ATMIN/ESRRG/JUNB/NR3C1/TFAP2A/ZFAT/CREB3L2/NFIB/YY1/EP300/ZNF33A/RBPJ/RREB1/ELF3/TFDP2/TFCP2L1/DDIT3/GATA3/KLF5	32
GO:0099106	ion channel regulator activity	12/975	139/18367	0.0661772305223841	0.315876883833648	AKAP9/CAV1/RASA1/DLG1/PHPT1/ATP2B4/SLC5A3/CALM1/WNK1/YWHAE/CALM2/SRI	12
GO:0098918	structural constituent of synapse	3/975	18/18367	0.067106247478281	0.318668641871222	ACTG1/DLG1/ERC1	3
GO:0019783	ubiquitin-like protein-specific protease activity	11/975	125/18367	0.0685293938358609	0.323035511287767	EIF3H/USP34/USP47/USP9X/USP22/USP10/USP27X/USP48/EIF3F/USP8/UCHL3	11
GO:0019787	ubiquitin-like protein transferase activity	32/975	458/18367	0.0688867335330696	0.323035511287767	MYCBP2/RNF43/TTC3/NHLRC3/TRIM44/UFL1/RANBP2/BIRC6/ZNF451/HECTD1/ZNRF3/HUWE1/UBR4/KLHL42/LMO7/RNF213/SEL1L/ANAPC11/TRIM33/HERC2/RBBP6/UBR5/TRIM56/SIAH1/SIAH2/MYLIP/UBE2C/UBE2L3/CDC42/TRIM24/UFC1/UBE2A	32
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	8/975	82/18367	0.0690723879427406	0.323035511287767	PFN1/ANXA2/SCIN/EXOC1/SYT7/SLC9A1/SVIL/SNX18	8
GO:0015036	disulfide oxidoreductase activity	5/975	42/18367	0.070122502538366	0.325268767872668	GSTO1/TXN/PDIA3/P4HB/PGK1	5
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	6/975	55/18367	0.0703079291760907	0.325268767872668	GPX3/PRDX6/PRDX1/GPX4/GSTP1/GPX1	6
GO:0008094	ATP-dependent activity, acting on DNA	10/975	111/18367	0.070603695834132	0.325268767872668	BPTF/ATRX/ANXA1/SMARCA2/CHD2/RAD50/CHD4/CHD8/SETX/CHD6	10
GO:0008242	omega peptidase activity	11/975	126/18367	0.0716721002647004	0.32822049658792	USP34/USP47/USP9X/USP22/USP10/USP27X/USP48/EIF3F/USP8/GGH/UCHL3	11
GO:0005310	dicarboxylic acid transmembrane transporter activity	4/975	30/18367	0.0723077551878356	0.32822049658792	SLC26A2/SLC1A5/SLC19A1/SLC13A3	4
GO:0022829	wide pore channel activity	4/975	30/18367	0.0723077551878356	0.32822049658792	GJA1/GJA5/VDAC1/VDAC2	4
GO:0042054	histone methyltransferase activity	6/975	56/18367	0.0753886585249286	0.336442398586421	ASH1L/KMT2C/SETD2/NSD1/SETD5/PRMT1	6
GO:0051287	NAD binding	6/975	56/18367	0.0753886585249286	0.336442398586421	GAPDH/LDHA/PARP1/IDH1/HADHA/HPGD	6
GO:0005246	calcium channel regulator activity	5/975	43/18367	0.0760510427319559	0.336442398586421	PHPT1/CALM1/YWHAE/CALM2/SRI	5
GO:0016504	peptidase activator activity	5/975	43/18367	0.0760510427319559	0.336442398586421	CAV1/APP/FBLN1/CTSC/PSME2	5
GO:0018024	histone-lysine N-methyltransferase activity	5/975	43/18367	0.0760510427319559	0.336442398586421	ASH1L/KMT2C/SETD2/NSD1/SETD5	5
GO:0000339	RNA cap binding	3/975	19/18367	0.0766623608010096	0.336442398586421	NCBP3/LARP1/AGO2	3
GO:0004129	cytochrome-c oxidase activity	3/975	19/18367	0.0766623608010096	0.336442398586421	COX6A1/COX5A/COX7B	3
GO:0004843	thiol-dependent deubiquitinase	10/975	113/18367	0.0775657111137571	0.338801172128958	USP34/USP47/USP9X/USP22/USP10/USP27X/USP48/EIF3F/USP8/UCHL3	10
GO:0031210	phosphatidylcholine binding	4/975	31/18367	0.0796927953637215	0.343235016310726	NF1/ABCA1/VDAC1/VDAC2	4
GO:0090482	vitamin transmembrane transporter activity	4/975	31/18367	0.0796927953637215	0.343235016310726	SLC2A1/SLC19A3/SLC52A3/SLC19A1	4
GO:0140318	protein transporter activity	4/975	31/18367	0.0796927953637215	0.343235016310726	LRP2/IGF1R/MCL1/ABCA1	4
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	6/975	57/18367	0.0806722718984206	0.345845017490451	GSTO1/TXN/PCYOX1/PDIA3/P4HB/PGK1	6
GO:0031072	heat shock protein binding	11/975	129/18367	0.0816446213812638	0.348344407333038	HSPA5/RPS3/TPR/PTGES3/HSPA1A/NR3C1/DNAJB1/DNAJB14/KPNB1/HSPA1B/DNAJC8	11
GO:0048029	monosaccharide binding	7/975	71/18367	0.0820076466507584	0.348344407333038	ALDOA/LMAN1/MANBA/COLEC12/UGP2/PYGL/TALDO1	7
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	31/975	450/18367	0.0833686454862349	0.352436095567721	JUN/FOS/JUND/FOSB/NFAT5/PBX1/SOX4/ISL1/EGR1/GTF2I/TBX3/ZNF292/EPAS1/ATMIN/ESRRG/JUNB/NR3C1/TFAP2A/ZFAT/CREB3L2/NFIB/YY1/ZNF33A/RBPJ/RREB1/ELF3/TFDP2/TFCP2L1/DDIT3/GATA3/KLF5	31
GO:0005496	steroid binding	9/975	100/18367	0.0838391133272771	0.352436095567721	CAV1/ESRRG/ABCA1/NR3C1/ESRRA/OSBPL9/VDAC1/NPC2/VDAC2	9
GO:0016247	channel regulator activity	12/975	145/18367	0.0847304494325569	0.352436095567721	AKAP9/CAV1/RASA1/DLG1/PHPT1/ATP2B4/SLC5A3/CALM1/WNK1/YWHAE/CALM2/SRI	12
GO:0017124	SH3 domain binding	11/975	130/18367	0.0851511366004426	0.352436095567721	LRP2/GJA1/WASF2/GPX1/FUT8/ZNF106/PTPN12/QKI/USP8/UVRAG/PTTG1	11
GO:0016018	cyclosporin A binding	3/975	20/18367	0.0867769220188341	0.352436095567721	NKTR/PPIA/PPIG	3
GO:0016500	protein-hormone receptor activity	3/975	20/18367	0.0867769220188341	0.352436095567721	LGR5/LGR4/IGF1R	3
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3/975	20/18367	0.0867769220188341	0.352436095567721	COX6A1/COX5A/COX7B	3
GO:0019211	phosphatase activator activity	3/975	20/18367	0.0867769220188341	0.352436095567721	PPP1R15A/CALM1/CALM2	3
GO:0030506	ankyrin binding	3/975	20/18367	0.0867769220188341	0.352436095567721	CDH1/PLEC/SPTBN1	3
GO:0097001	ceramide binding	3/975	20/18367	0.0867769220188341	0.352436095567721	PSAP/VDAC1/VDAC2	3
GO:0030515	snoRNA binding	4/975	32/18367	0.0874361065358926	0.353562596734657	PRKDC/SNU13/NHP2/NOP10	4
GO:0008276	protein methyltransferase activity	8/975	88/18367	0.0951122113146789	0.368327398255401	ASH1L/KMT2C/SETD2/NSD1/DNMT3A/SETD5/LCMT1/PRMT1	8
GO:0004864	protein phosphatase inhibitor activity	5/975	46/18367	0.0953943355877492	0.368327398255401	BOD1L1/PPP1R10/PHACTR2/PPP1R14B/LGALS3	5
GO:0008172	S-methyltransferase activity	2/975	10/18367	0.0954628246018317	0.368327398255401	MTR/DNMT3A	2
GO:0008190	eukaryotic initiation factor 4E binding	2/975	10/18367	0.0954628246018317	0.368327398255401	EIF4G1/LARP1	2
GO:0008330	protein tyrosine/threonine phosphatase activity	2/975	10/18367	0.0954628246018317	0.368327398255401	DUSP6/DUSP1	2
GO:0015924	mannosyl-oligosaccharide mannosidase activity	2/975	10/18367	0.0954628246018317	0.368327398255401	MAN2A1/MAN1A2	2
GO:0034511	U3 snoRNA binding	2/975	10/18367	0.0954628246018317	0.368327398255401	PRKDC/SNU13	2
GO:0046974	histone methyltransferase activity (H3-K9 specific)	2/975	10/18367	0.0954628246018317	0.368327398255401	ASH1L/SETD5	2
GO:0070016	armadillo repeat domain binding	2/975	10/18367	0.0954628246018317	0.368327398255401	TCF7L2/CHD8	2
GO:0097027	ubiquitin-protein transferase activator activity	2/975	10/18367	0.0954628246018317	0.368327398255401	UBE2L3/CDC20	2
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	2/975	10/18367	0.0954628246018317	0.368327398255401	CFLAR/CASP4	2
GO:0031490	chromatin DNA binding	9/975	103/18367	0.0965226335795533	0.37087119790318	JMJD1C/CHD4/EP300/ZFX/ACTN4/HMGN3/SBNO1/HNRNPC/HNRNPU	9
GO:0032934	sterol binding	6/975	60/18367	0.0977249066464036	0.373939105597396	CAV1/ABCA1/OSBPL9/VDAC1/NPC2/VDAC2	6
GO:0035254	glutamate receptor binding	5/975	47/18367	0.102347632764893	0.390016082058809	FUS/MYL12A/CALM1/HOMER1/FLOT2	5
GO:0043621	protein self-association	6/975	61/18367	0.103802570857615	0.392917172719762	SLC2A1/PLEC/CTSC/FOXP1/VAMP2/MDH2	6
GO:0008376	acetylgalactosaminyltransferase activity	4/975	34/18367	0.103957567296265	0.392917172719762	EXTL2/GALNT11/CHPF/GALNT1	4
GO:0017075	syntaxin-1 binding	3/975	22/18367	0.108560010230115	0.40296698217693	SLC6A4/VAMP2/VAMP3	3
GO:0008509	anion transmembrane transporter activity	22/975	314/18367	0.112671830232694	0.40296698217693	SLC26A2/CLIC3/SLC2A1/GJA1/SLC38A1/GABRE/SLC38A2/CLDN4/SLC16A12/SLC9A1/SLC1A5/SLC13A4/CLIC1/SLC52A3/SLC6A4/SLC25A6/SLC3A2/SLC35B4/SLC19A1/VDAC1/SLC13A3/VDAC2	22
GO:0005049	nuclear export signal receptor activity	2/975	11/18367	0.112708907541927	0.40296698217693	RAN/XPO1	2
GO:0005536	glucose binding	2/975	11/18367	0.112708907541927	0.40296698217693	UGP2/PYGL	2
GO:0010485	H4 histone acetyltransferase activity	2/975	11/18367	0.112708907541927	0.40296698217693	USP22/EP300	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/975	11/18367	0.112708907541927	0.40296698217693	PCYOX1/P4HB	2
GO:0022889	serine transmembrane transporter activity	2/975	11/18367	0.112708907541927	0.40296698217693	SLC38A2/SLC1A5	2
GO:0035197	siRNA binding	2/975	11/18367	0.112708907541927	0.40296698217693	DICER1/AGO2	2
GO:0035673	oligopeptide transmembrane transporter activity	2/975	11/18367	0.112708907541927	0.40296698217693	GJA1/SLC13A3	2
GO:0043560	insulin receptor substrate binding	2/975	11/18367	0.112708907541927	0.40296698217693	IGF1R/PIK3R1	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	2/975	11/18367	0.112708907541927	0.40296698217693	TXN/PGK1	2
GO:0061665	SUMO ligase activity	2/975	11/18367	0.112708907541927	0.40296698217693	RANBP2/ZNF451	2
GO:0099186	structural constituent of postsynapse	2/975	11/18367	0.112708907541927	0.40296698217693	ACTG1/DLG1	2
GO:1901612	cardiolipin binding	2/975	11/18367	0.112708907541927	0.40296698217693	MME/STOML2	2
GO:0038024	cargo receptor activity	7/975	77/18367	0.113816396143137	0.405361472417482	LRP2/LRP1/MIA3/TFRC/ABCA1/COLEC12/LGALS3BP	7
GO:0051213	dioxygenase activity	8/975	92/18367	0.115185185100186	0.408664679704109	TET2/KDM5A/KDM5B/RSBN1L/JMJD1C/ASPH/KDM2A/P4HB	8
GO:0019212	phosphatase inhibitor activity	5/975	49/18367	0.11698161553264	0.413454106806201	BOD1L1/PPP1R10/PHACTR2/PPP1R14B/LGALS3	5
GO:0061659	ubiquitin-like protein ligase activity	22/975	316/18367	0.118181405989574	0.415196371820487	MYCBP2/RNF43/NHLRC3/TRIM44/UFL1/RANBP2/ZNF451/HECTD1/ZNRF3/HUWE1/UBR4/ANAPC11/HERC2/RBBP6/UBR5/TRIM56/SIAH1/SIAH2/MYLIP/UBE2C/CDC42/TRIM24	22
GO:0003697	single-stranded DNA binding	10/975	123/18367	0.118531350811737	0.415196371820487	ANXA1/YBX1/RAD50/PURA/HNRNPA1/RBMS1/PCBP2/RTF1/XPC/HNRNPU	10
GO:0022853	active ion transmembrane transporter activity	19/975	267/18367	0.119484599923256	0.415196371820487	SLC26A2/ATP2B1/SLC38A1/SLC38A2/COX6A1/UQCRH/ATP2B4/ATP13A3/SLC5A3/SLC9A1/ATP6V0E1/SLC13A4/COX5A/SLC6A4/SLC25A6/SLC3A2/COX7B/SLC19A1/SLC13A3	19
GO:0001221	transcription coregulator binding	7/975	78/18367	0.119669452274427	0.415196371820487	EPAS1/CHD4/MTF2/EP300/NEK6/CHD6/VGLL4	7
GO:0030215	semaphorin receptor binding	3/975	23/18367	0.120164824673748	0.415196371820487	SEMA6A/SEMA6D/PLXNB1	3
GO:0050750	low-density lipoprotein particle receptor binding	3/975	23/18367	0.120164824673748	0.415196371820487	HSP90B1/CLTC/LRPAP1	3
GO:0000217	DNA secondary structure binding	4/975	36/18367	0.121782582601217	0.417669153661951	HMGB3/HMGA1/YY1/XPC	4
GO:0061631	ubiquitin conjugating enzyme activity	4/975	36/18367	0.121782582601217	0.417669153661951	BIRC6/UBE2C/UBE2L3/UBE2A	4
GO:0015485	cholesterol binding	5/975	50/18367	0.124650114678931	0.425926222113248	CAV1/ABCA1/VDAC1/NPC2/VDAC2	5
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	8/975	94/18367	0.126011996528798	0.428996723476718	GANAB/AGL/GAA/MANBA/MAN2A1/MAN1A2/HEXA/NAGLU	8
GO:0005201	extracellular matrix structural constituent	13/975	172/18367	0.126911375812112	0.430475948725332	FBN1/FBN2/COL14A1/LAMB1/LAMC1/LAMA5/FBLN1/COL4A2/FRAS1/LTBP1/VWA1/EFEMP1/MFAP5	13
GO:0005024	transforming growth factor beta-activated receptor activity	2/975	12/18367	0.130674015720313	0.433706589810072	TGFBR3/LTBP1	2
GO:0005095	GTPase inhibitor activity	2/975	12/18367	0.130674015720313	0.433706589810072	IQGAP2/IQGAP1	2
GO:0035256	G protein-coupled glutamate receptor binding	2/975	12/18367	0.130674015720313	0.433706589810072	CALM1/HOMER1	2
GO:0043047	single-stranded telomeric DNA binding	2/975	12/18367	0.130674015720313	0.433706589810072	RAD50/HNRNPA1	2
GO:0046790	virion binding	2/975	12/18367	0.130674015720313	0.433706589810072	ANXA2/PPIA	2
GO:0070410	co-SMAD binding	2/975	12/18367	0.130674015720313	0.433706589810072	USP9X/TRIM33	2
GO:0015035	protein-disulfide reductase activity	4/975	37/18367	0.13115229572951	0.433739378019737	TXN/PDIA3/P4HB/PGK1	4
GO:0016860	intramolecular oxidoreductase activity	5/975	51/18367	0.132544032107188	0.436782112922619	TPI1/MIF/PTGES3/PDIA3/P4HB	5
GO:0008237	metallopeptidase activity	14/975	190/18367	0.13475276549326	0.442486031371485	ADAMTS6/ADAMTS1/ENPEP/EIF3H/TFRC/CPD/ADAMTS19/YME1L1/MMP14/MMP15/MME/EIF3F/NPEPPS/AFG3L2	14
GO:0019199	transmembrane receptor protein kinase activity	11/975	143/18367	0.138983733500612	0.454766562620377	EGFR/NRP2/MET/CRIM1/EPHB4/TGFBR3/LTBP1/NRP1/IGF1R/BAZ1B/EFEMP1	11
GO:1901682	sulfur compound transmembrane transporter activity	5/975	52/18367	0.140656137878259	0.455904796456377	SLC26A2/GJA1/SLC13A4/SLC19A3/SLC13A3	5
GO:0015175	neutral amino acid transmembrane transporter activity	4/975	38/18367	0.140808608840738	0.455904796456377	SLC38A1/SLC38A2/SLC1A5/SLC3A2	4
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4/975	38/18367	0.140808608840738	0.455904796456377	RPS3/TCERG1/SIAH1/SIAH2	4
GO:0005112	Notch binding	3/975	25/18367	0.144636381177993	0.462174367650417	AAK1/GALNT11/JAG1	3
GO:0106310	protein serine kinase activity	24/975	360/18367	0.148884303130106	0.462174367650417	AAK1/PRKDC/CDK6/ROCK1/PKN2/MAP3K4/NRK/PRPF4B/RPS6KA5/LATS2/SMG1/TAOK3/TAOK1/MAST4/CDK12/MAPK14/WNK1/EIF2AK4/NEK6/SLK/STK17A/CAMK2G/CDK1/AURKA	24
GO:0017069	snRNA binding	5/975	53/18367	0.14897881587348	0.462174367650417	DDX39B/EIF5A/LSM3/HNRNPU/SNU13	5
GO:0008179	adenylate cyclase binding	2/975	13/18367	0.149233408129022	0.462174367650417	CALM1/CALM2	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/975	13/18367	0.149233408129022	0.462174367650417	SLC26A2/SLC13A4	2
GO:0008494	translation activator activity	2/975	13/18367	0.149233408129022	0.462174367650417	LARP1/PABPC1	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	2/975	13/18367	0.149233408129022	0.462174367650417	TXN/PGK1	2
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	2/975	13/18367	0.149233408129022	0.462174367650417	DUSP6/DUSP1	2
GO:0031386	protein tag	2/975	13/18367	0.149233408129022	0.462174367650417	RPS27A/UBA52	2
GO:0031432	titin binding	2/975	13/18367	0.149233408129022	0.462174367650417	CALM1/CALM2	2
GO:0034450	ubiquitin-ubiquitin ligase activity	2/975	13/18367	0.149233408129022	0.462174367650417	ANAPC11/UBR5	2
GO:0051011	microtubule minus-end binding	2/975	13/18367	0.149233408129022	0.462174367650417	MACF1/CAMSAP2	2
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	2/975	13/18367	0.149233408129022	0.462174367650417	CKS1B/CCNB1	2
GO:0004402	histone acetyltransferase activity	4/975	39/18367	0.150737204046491	0.463729737365617	NCOA3/USP22/EP300/TAF9	4
GO:0050997	quaternary ammonium group binding	4/975	39/18367	0.150737204046491	0.463729737365617	NF1/ABCA1/VDAC1/VDAC2	4
GO:0004175	endopeptidase activity	28/975	430/18367	0.154412252446898	0.472545410517877	ADAMTS6/ADAMTS1/CTSC/USP34/USP47/CTSL/USP9X/CTSD/CTSV/USP10/ADAMTS19/YME1L1/MMP14/PCSK7/MBTPS1/PDIA3/USP48/MMP15/CFLAR/HTRA1/MME/PSMB3/DPP4/USP8/SPPL3/AFG3L2/PSMB7/CASP4	28
GO:0046982	protein heterodimerization activity	22/975	328/18367	0.154623390266649	0.472545410517877	CAV1/TENM3/ITGB1/ADRB1/JAM3/RAN/BHLHE41/EPAS1/PIK3R1/MCL1/XBP1/TAF3/HEXA/P4HB/DDIT3/TPM4/YWHAE/CAV2/SRI/TAF9/AURKA/KRT10	22
GO:0004364	glutathione transferase activity	3/975	26/18367	0.157436406771384	0.476630058692028	GSTO1/GSTP1/GSTA3	3
GO:0097602	cullin family protein binding	3/975	26/18367	0.157436406771384	0.476630058692028	DDB1/SKP1/ANAPC11	3
GO:0005544	calcium-dependent phospholipid binding	5/975	54/18367	0.157504101468424	0.476630058692028	ANXA1/ANXA2/ANXA4/SYT7/ANXA3	5
GO:0003925	G protein activity	4/975	40/18367	0.160923340699069	0.485390923411524	RAB11A/RHOA/CDC42/KRAS	4
GO:0004842	ubiquitin-protein transferase activity	28/975	433/18367	0.163096744501302	0.490349303273395	MYCBP2/RNF43/TTC3/NHLRC3/TRIM44/BIRC6/HECTD1/ZNRF3/HUWE1/UBR4/KLHL42/LMO7/RNF213/SEL1L/ANAPC11/TRIM33/HERC2/RBBP6/UBR5/TRIM56/SIAH1/SIAH2/MYLIP/UBE2C/UBE2L3/CDC42/TRIM24/UBE2A	28
GO:0004298	threonine-type endopeptidase activity	2/975	14/18367	0.168273537405679	0.499427229607881	PSMB3/PSMB7	2
GO:0015373	anion:sodium symporter activity	2/975	14/18367	0.168273537405679	0.499427229607881	SLC13A4/SLC6A4	2
GO:0032977	membrane insertase activity	2/975	14/18367	0.168273537405679	0.499427229607881	EMC1/EMC10	2
GO:0071837	HMG box domain binding	2/975	14/18367	0.168273537405679	0.499427229607881	JUN/GATA3	2
GO:0015215	nucleotide transmembrane transporter activity	3/975	27/18367	0.170568221552979	0.501416422723996	SLC25A36/SLC25A6/SLC19A1	3
GO:0043425	bHLH transcription factor binding	3/975	27/18367	0.170568221552979	0.501416422723996	ISL1/BHLHE41/KLF5	3
GO:0045499	chemorepellent activity	3/975	27/18367	0.170568221552979	0.501416422723996	SEMA6A/SEMA6D/DPP4	3
GO:0061733	peptide-lysine-N-acetyltransferase activity	4/975	41/18367	0.171351941109459	0.501649842156141	NCOA3/USP22/EP300/TAF9	4
GO:0042562	hormone binding	7/975	86/18367	0.171731101472459	0.501649842156141	EGFR/LRP2/IGF1R/PRLR/PIK3R1/SLC40A1/NR3C1	7
GO:0004725	protein tyrosine phosphatase activity	8/975	102/18367	0.174249743570647	0.506581786406477	DUSP6/DUSP1/PTPN14/PTPRF/PTPRA/PTPN12/PTPRE/CDKN3	8
GO:0031491	nucleosome binding	6/975	71/18367	0.174513595965082	0.506581786406477	HP1BP3/ARID1A/CHD4/SUPT6H/HMGN3/HNRNPC	6
GO:0045309	protein phosphorylated amino acid binding	5/975	56/18367	0.175129116753807	0.506779881606329	PFN1/RASA1/PIK3R1/RTF1/YWHAE	5
GO:0019894	kinesin binding	4/975	42/18367	0.182007671485364	0.517268050586386	KTN1/NEK6/CLSTN1/SPAG9	4
GO:0008235	metalloexopeptidase activity	6/975	72/18367	0.182477833472383	0.517268050586386	ENPEP/TFRC/CPD/MMP14/MMP15/NPEPPS	6
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	6/975	72/18367	0.182477833472383	0.517268050586386	COX6A1/UQCRH/COX5A/COX7B/NDUFA13/NDUFA6	6
GO:0003785	actin monomer binding	3/975	28/18367	0.183998931905045	0.517268050586386	PFN1/TMSB4X/TMSB10	3
GO:0008514	organic anion transmembrane transporter activity	13/975	185/18367	0.18521596289346	0.517268050586386	SLC26A2/SLC2A1/GJA1/SLC38A1/SLC38A2/SLC16A12/SLC1A5/SLC52A3/SLC25A6/SLC3A2/SLC35B4/SLC19A1/SLC13A3	13
GO:0003924	GTPase activity	22/975	337/18367	0.185642308785808	0.517268050586386	EEF1A1/RHOB/RASA1/TUBA1C/TUBA1B/RAN/GNAQ/RAB11A/ARHGAP5/RHOA/RAB6A/GNA12/TUBB4B/RHOBTB3/CDC42/KRAS/ARL4A/RAB17/ARF4/RHOC/TUBB6/RAB25	22
GO:0004559	alpha-mannosidase activity	2/975	15/18367	0.187691214899596	0.517268050586386	MAN2A1/MAN1A2	2
GO:0005041	low-density lipoprotein particle receptor activity	2/975	15/18367	0.187691214899596	0.517268050586386	LRP2/LRP1	2
GO:0010851	cyclase regulator activity	2/975	15/18367	0.187691214899596	0.517268050586386	CALM1/CALM2	2
GO:0015929	hexosaminidase activity	2/975	15/18367	0.187691214899596	0.517268050586386	HEXA/NAGLU	2
GO:0070742	C2H2 zinc finger domain binding	2/975	15/18367	0.187691214899596	0.517268050586386	SRRM2/TAF9	2
GO:0071933	Arp2/3 complex binding	2/975	15/18367	0.187691214899596	0.517268050586386	IQGAP2/WASF2	2
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	2/975	15/18367	0.187691214899596	0.517268050586386	CFLAR/CASP4	2
GO:0098847	sequence-specific single stranded DNA binding	2/975	15/18367	0.187691214899596	0.517268050586386	RAD50/HNRNPA1	2
GO:1901611	phosphatidylglycerol binding	2/975	15/18367	0.187691214899596	0.517268050586386	MME/STOML2	2
GO:1904680	peptide transmembrane transporter activity	2/975	15/18367	0.187691214899596	0.517268050586386	GJA1/SLC13A3	2
GO:0015370	solute:sodium symporter activity	6/975	73/18367	0.190583109191389	0.522130056542089	SLC38A1/SLC38A2/SLC5A3/SLC13A4/SLC6A4/SLC13A3	6
GO:0033293	monocarboxylic acid binding	6/975	73/18367	0.190583109191389	0.522130056542089	NR2F2/PSAP/GSTP1/S100A9/PYGL/RXRA	6
GO:0030544	Hsp70 protein binding	4/975	43/18367	0.192875018024175	0.526827199443471	RPS3/DNAJB1/DNAJB14/DNAJC8	4
GO:0051117	ATPase binding	7/975	89/18367	0.193435472797819	0.526827199443471	EGFR/CAV1/ABCA1/DNAJB1/EZR/SNU13/TAF9	7
GO:0008017	microtubule binding	18/975	271/18367	0.194317070798001	0.527676268501316	GAPDH/CLIP1/MACF1/DST/RPS3/CEP350/KIF5B/S100A9/HOOK2/RAB11A/CAMSAP2/EML4/HOOK3/EZR/CAPN6/NUSAP1/UXT/CNN3	18
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	3/975	29/18367	0.19769616417415	0.529094358454517	CDK6/CDK12/CDK1	3
GO:0015301	anion:anion antiporter activity	3/975	29/18367	0.19769616417415	0.529094358454517	SLC26A2/SLC25A6/SLC19A1	3
GO:0046625	sphingolipid binding	3/975	29/18367	0.19769616417415	0.529094358454517	PSAP/VDAC1/VDAC2	3
GO:0051787	misfolded protein binding	3/975	29/18367	0.19769616417415	0.529094358454517	HSPA5/HSPA1A/HSPA1B	3
GO:0097472	cyclin-dependent protein kinase activity	3/975	29/18367	0.19769616417415	0.529094358454517	CDK6/CDK12/CDK1	3
GO:0019905	syntaxin binding	6/975	74/18367	0.198823471535937	0.530577909631925	SYT7/RAB11A/ABCA1/SLC6A4/VAMP2/VAMP3	6
GO:0016279	protein-lysine N-methyltransferase activity	5/975	59/18367	0.202871108180865	0.531982723206656	ASH1L/KMT2C/SETD2/NSD1/SETD5	5
GO:0008375	acetylglucosaminyltransferase activity	4/975	44/18367	0.203938358142304	0.531982723206656	EXTL2/GCNT2/HEXA/B3GNT2	4
GO:0051879	Hsp90 protein binding	4/975	44/18367	0.203938358142304	0.531982723206656	RPS3/PTGES3/NR3C1/KPNB1	4
GO:0019955	cytokine binding	10/975	139/18367	0.204151953830718	0.531982723206656	NRP2/CSF3R/ITGAV/ITGB1/TGFBR3/IL6ST/LTBP1/NRP1/PRLR/LTBP3	10
GO:0005085	guanyl-nucleotide exchange factor activity	15/975	223/18367	0.207035187741865	0.531982723206656	EEF1B2/MYCBP2/DOCK8/AKAP13/ADRB1/EPS8L1/DENND4C/HERC2/DOCK9/GAPVD1/RAB3GAP2/ARFGEF1/EEF1D/ARF4/NUCB2	15
GO:0000900	translation repressor activity, mRNA regulatory element binding	2/975	16/18367	0.207392832697195	0.531982723206656	PURA/CELF1	2
GO:0005092	GDP-dissociation inhibitor activity	2/975	16/18367	0.207392832697195	0.531982723206656	CHML/RANBP1	2
GO:0005159	insulin-like growth factor receptor binding	2/975	16/18367	0.207392832697195	0.531982723206656	IGF2/PIK3R1	2
GO:0005283	amino acid:sodium symporter activity	2/975	16/18367	0.207392832697195	0.531982723206656	SLC38A1/SLC38A2	2
GO:0015556	C4-dicarboxylate transmembrane transporter activity	2/975	16/18367	0.207392832697195	0.531982723206656	SLC1A5/SLC13A3	2
GO:0016208	AMP binding	2/975	16/18367	0.207392832697195	0.531982723206656	ACSS1/PYGL	2
GO:0035497	cAMP response element binding	2/975	16/18367	0.207392832697195	0.531982723206656	JUN/CREB3L2	2
GO:0070403	NAD+ binding	2/975	16/18367	0.207392832697195	0.531982723206656	HADHA/HPGD	2
GO:1990380	Lys48-specific deubiquitinase activity	2/975	16/18367	0.207392832697195	0.531982723206656	USP9X/USP27X	2
GO:1902936	phosphatidylinositol bisphosphate binding	8/975	107/18367	0.208000393277855	0.532067304351639	PFN1/ANXA2/SCIN/EXOC1/SYT7/SLC9A1/SVIL/SNX18	8
GO:1901981	phosphatidylinositol phosphate binding	12/975	173/18367	0.209180487908274	0.533611933341767	PFN1/IQGAP2/IQGAP1/ANXA2/ZFYVE16/SCIN/EXOC1/SYT7/SLC9A1/ARHGAP32/SVIL/SNX18	12
GO:0005343	organic acid:sodium symporter activity	3/975	30/18367	0.211628209617074	0.534370106881691	SLC38A1/SLC38A2/SLC13A3	3
GO:0005543	phospholipid binding	29/975	466/18367	0.212107240789241	0.534370106881691	PFN1/IQGAP2/IQGAP1/ANXA1/ANXA2/PSAP/EEA1/ANXA4/TLN1/NF1/ZFYVE16/SCIN/EXOC1/SYT7/SPTBN1/SLC9A1/ARHGAP32/ABCA1/SVIL/JAG1/MME/EPN2/SNX18/MYOF/VAMP2/ANXA3/VDAC1/VDAC2/STOML2	29
GO:0001786	phosphatidylserine binding	5/975	60/18367	0.212429853774906	0.534370106881691	ANXA2/TLN1/SCIN/SYT7/MME	5
GO:0016278	lysine N-methyltransferase activity	5/975	60/18367	0.212429853774906	0.534370106881691	ASH1L/KMT2C/SETD2/NSD1/SETD5	5
GO:0004714	transmembrane receptor protein tyrosine kinase activity	9/975	124/18367	0.212940139783309	0.534370106881691	EGFR/NRP2/MET/CRIM1/EPHB4/NRP1/IGF1R/BAZ1B/EFEMP1	9
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	9/975	124/18367	0.212940139783309	0.534370106881691	LDHA/DHRS2/AKR1B1/IDH1/GCLM/HADHA/MDH2/HPGD/IMPDH2	9
GO:0004721	phosphoprotein phosphatase activity	12/975	174/18367	0.214666620256074	0.537246730694931	DUSP6/DUSP1/DLG1/PTPN14/PHPT1/PTPRF/CTDSPL/PTPRA/PTPN12/PTPRE/CAMK2G/CDKN3	12
GO:0043130	ubiquitin binding	7/975	92/18367	0.216165170447669	0.539538942950245	HSPB1/N4BP2/UBR5/FAF2/CKS1B/UCHL3/UBE2A	7
GO:0015179	L-amino acid transmembrane transporter activity	5/975	61/18367	0.222128718321093	0.552424959688949	SLC38A1/SLC38A2/SLC1A5/SLC7A6/SLC3A2	5
GO:0000400	four-way junction DNA binding	2/975	17/18367	0.227293638921695	0.552424959688949	HMGB3/YY1	2
GO:0004697	protein kinase C activity	2/975	17/18367	0.227293638921695	0.552424959688949	PKN2/SMG1	2
GO:0005324	long-chain fatty acid transporter activity	2/975	17/18367	0.227293638921695	0.552424959688949	SLC2A1/SLC27A2	2
GO:0008308	voltage-gated anion channel activity	2/975	17/18367	0.227293638921695	0.552424959688949	VDAC1/VDAC2	2
GO:0008381	mechanosensitive ion channel activity	2/975	17/18367	0.227293638921695	0.552424959688949	TMC5/TMEM150C	2
GO:0015116	sulfate transmembrane transporter activity	2/975	17/18367	0.227293638921695	0.552424959688949	SLC26A2/SLC13A4	2
GO:0034185	apolipoprotein binding	2/975	17/18367	0.227293638921695	0.552424959688949	LRP1/ABCA1	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/975	17/18367	0.227293638921695	0.552424959688949	ASH1L/KMT2C	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/975	17/18367	0.227293638921695	0.552424959688949	C1GALT1/B3GNT2	2
GO:0004222	metalloendopeptidase activity	8/975	111/18367	0.236686657153584	0.571487075237523	ADAMTS6/ADAMTS1/ADAMTS19/YME1L1/MMP14/MMP15/MME/AFG3L2	8
GO:0032182	ubiquitin-like protein binding	8/975	111/18367	0.236686657153584	0.571487075237523	HSPB1/N4BP2/HERC2/UBR5/FAF2/CKS1B/UCHL3/UBE2A	8
GO:0019829	ATPase-coupled cation transmembrane transporter activity	4/975	47/18367	0.23814784312347	0.571487075237523	ATP2B1/ATP2B4/ATP13A3/ATP6V0E1	4
GO:0001223	transcription coactivator binding	3/975	32/18367	0.240073944133257	0.571487075237523	EPAS1/EP300/VGLL4	3
GO:0008378	galactosyltransferase activity	3/975	32/18367	0.240073944133257	0.571487075237523	C1GALT1/B4GALT5/B3GNT2	3
GO:0015605	organophosphate ester transmembrane transporter activity	3/975	32/18367	0.240073944133257	0.571487075237523	SLC25A36/SLC25A6/SLC19A1	3
GO:0030332	cyclin binding	3/975	32/18367	0.240073944133257	0.571487075237523	CDK6/CDK12/CDK1	3
GO:0071889	14-3-3 protein binding	3/975	32/18367	0.240073944133257	0.571487075237523	ZFP36L1/PPP1R12A/YWHAQ	3
GO:0016835	carbon-oxygen lyase activity	6/975	79/18367	0.241834532487481	0.574201992521558	TPI1/ENO1/RPS3/HACD3/CDYL/HADHA	6
GO:0000295	adenine nucleotide transmembrane transporter activity	2/975	18/18367	0.247317062852122	0.574771365605494	SLC25A6/SLC19A1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/975	18/18367	0.247317062852122	0.574771365605494	SLC25A6/SLC19A1	2
GO:0030228	lipoprotein particle receptor activity	2/975	18/18367	0.247317062852122	0.574771365605494	LRP2/LRP1	2
GO:0033549	MAP kinase phosphatase activity	2/975	18/18367	0.247317062852122	0.574771365605494	DUSP6/DUSP1	2
GO:0046624	sphingolipid transporter activity	2/975	18/18367	0.247317062852122	0.574771365605494	ABCA1/ATP10D	2
GO:0047834	D-threo-aldose 1-dehydrogenase activity	2/975	18/18367	0.247317062852122	0.574771365605494	AKR1B1/GCLM	2
GO:0070122	isopeptidase activity	2/975	18/18367	0.247317062852122	0.574771365605494	EIF3H/EIF3F	2
GO:0140597	protein carrier activity	2/975	18/18367	0.247317062852122	0.574771365605494	EMC1/EMC10	2
GO:0016758	hexosyltransferase activity	13/975	197/18367	0.248379332393686	0.574771365605494	AGL/EXTL2/GALNT11/CHPF/GCNT2/C1GALT1/RPN2/FUT8/B4GALT5/HEXA/B3GNT2/PYGL/GALNT1	13
GO:0046943	carboxylic acid transmembrane transporter activity	11/975	163/18367	0.248758177533387	0.574771365605494	SLC26A2/SLC38A1/SLC38A2/SLC27A2/SLC16A12/SLC1A5/SLC38A10/SLC7A6/SLC3A2/SLC19A1/SLC13A3	11
GO:0022804	active transmembrane transporter activity	25/975	406/18367	0.24890207085076	0.574771365605494	SLC26A2/ATP2B1/SLC38A1/SLC38A2/COX6A1/UQCRH/ATP2B4/ATP13A3/SLC5A3/SLC16A12/SLC9A1/ABCA1/ATP6V0E1/SLC1A5/SLC13A4/COX5A/SLC6A4/SLC25A6/SLC7A6/SLC3A2/COX7B/SLC19A1/SLC13A3/NDUFA13/NDUFA6	25
GO:0005154	epidermal growth factor receptor binding	3/975	33/18367	0.254528543392614	0.582904525082533	EFEMP1/ATXN2/ARF4	3
GO:0140323	solute:anion antiporter activity	3/975	33/18367	0.254528543392614	0.582904525082533	SLC26A2/SLC25A6/SLC19A1	3
GO:0015399	primary active transmembrane transporter activity	12/975	181/18367	0.25466880685446	0.582904525082533	SLC26A2/ATP2B1/COX6A1/UQCRH/ATP2B4/ATP13A3/ABCA1/ATP6V0E1/COX5A/COX7B/NDUFA13/NDUFA6	12
GO:0005342	organic acid transmembrane transporter activity	11/975	164/18367	0.254942043907587	0.582904525082533	SLC26A2/SLC38A1/SLC38A2/SLC27A2/SLC16A12/SLC1A5/SLC38A10/SLC7A6/SLC3A2/SLC19A1/SLC13A3	11
GO:0008170	N-methyltransferase activity	7/975	97/18367	0.255998291598606	0.583877876897314	ASH1L/KMT2C/SETD2/NSD1/SETD5/RNMT/PRMT1	7
GO:0034212	peptide N-acetyltransferase activity	4/975	49/18367	0.261648523217252	0.59529860564908	NCOA3/USP22/EP300/TAF9	4
GO:0061630	ubiquitin protein ligase activity	19/975	304/18367	0.263434052965555	0.597891992760058	MYCBP2/RNF43/NHLRC3/TRIM44/HECTD1/ZNRF3/HUWE1/UBR4/ANAPC11/HERC2/RBBP6/UBR5/TRIM56/SIAH1/SIAH2/MYLIP/UBE2C/CDC42/TRIM24	19
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	2/975	19/18367	0.267394086622841	0.6024499372573	GALNT11/GALNT1	2
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/975	19/18367	0.267394086622841	0.6024499372573	TGFBR3/LTBP1	2
GO:0035615	clathrin adaptor activity	2/975	19/18367	0.267394086622841	0.6024499372573	STON1/AP2A2	2
GO:0043548	phosphatidylinositol 3-kinase binding	3/975	34/18367	0.269099928176132	0.604821683230821	IGF1R/PIK3R1/CALM1	3
GO:0003730	mRNA 3'-UTR binding	13/975	201/18367	0.271058531528686	0.607476936721303	FUS/ZFP36L1/DDX5/PUM1/IGF2BP3/CELF1/TIA1/PUM2/RBMS1/LARP1/PABPC1/HNRNPC/HNRNPU	13
GO:0030246	carbohydrate binding	17/975	271/18367	0.27312137853445	0.607476936721303	ALDOA/LMAN1/GANAB/AGL/GAA/GALNT11/CRYBG3/MANBA/MAN2A1/LGALS3/COLEC12/MLEC/UGP2/PYGL/GALNT1/SIGLEC6/TALDO1	17
GO:0015932	nucleobase-containing compound transmembrane transporter activity	4/975	50/18367	0.273561428307541	0.607476936721303	SLC25A36/SLC25A6/SLC35B4/SLC19A1	4
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	4/975	50/18367	0.273561428307541	0.607476936721303	CCNL1/CKS1B/CCNB1/CCNE1	4
GO:0030159	signaling receptor complex adaptor activity	4/975	50/18367	0.273561428307541	0.607476936721303	DLG5/PIK3R1/SORBS1/SPAG9	4
GO:0042887	amide transmembrane transporter activity	3/975	35/18367	0.283761176985836	0.623396776564681	GJA1/SLC19A1/SLC13A3	3
GO:0015171	amino acid transmembrane transporter activity	6/975	84/18367	0.287270127605207	0.623396776564681	SLC38A1/SLC38A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2	6
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2/975	20/18367	0.287462660467731	0.623396776564681	FOS/REST	2
GO:0001091	RNA polymerase II general transcription initiation factor binding	2/975	20/18367	0.287462660467731	0.623396776564681	EDF1/HNRNPU	2
GO:0001972	retinoic acid binding	2/975	20/18367	0.287462660467731	0.623396776564681	NR2F2/RXRA	2
GO:0003756	protein disulfide isomerase activity	2/975	20/18367	0.287462660467731	0.623396776564681	PDIA3/P4HB	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	2/975	20/18367	0.287462660467731	0.623396776564681	PDIA3/P4HB	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/975	20/18367	0.287462660467731	0.623396776564681	GNAQ/GNA12	2
GO:0050145	nucleoside monophosphate kinase activity	2/975	20/18367	0.287462660467731	0.623396776564681	DLG1/AK2	2
GO:0140312	cargo adaptor activity	2/975	20/18367	0.287462660467731	0.623396776564681	STON1/AP2A2	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	19/975	310/18367	0.291559905379606	0.630804842012885	JUN/PEG3/NFE2L3/ENO1/ZFHX3/LRRFIP1/HIC2/TBX3/BHLHE41/IRX2/NR3C1/FOXP1/SMAD5/TFAP2A/YY1/NR2F6/REST/GATA3/HES1	19
GO:0008080	N-acetyltransferase activity	5/975	68/18367	0.293144620368301	0.632755054687755	NCOA3/USP22/HGSNAT/EP300/TAF9	5
GO:0004713	protein tyrosine kinase activity	9/975	136/18367	0.296585582215506	0.636862908918702	EGFR/NRP2/MET/CRIM1/EPHB4/NRP1/IGF1R/BAZ1B/EFEMP1	9
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	9/975	136/18367	0.296585582215506	0.636862908918702	LDHA/DHRS2/AKR1B1/IDH1/GCLM/HADHA/MDH2/HPGD/IMPDH2	9
GO:0017046	peptide hormone binding	4/975	52/18367	0.297638473081645	0.636862908918702	IGF1R/PRLR/PIK3R1/SLC40A1	4
GO:0015248	sterol transporter activity	3/975	36/18367	0.298486503748074	0.636862908918702	ABCA1/OSBPL9/NPC2	3
GO:0043394	proteoglycan binding	3/975	36/18367	0.298486503748074	0.636862908918702	LRP1/PTPRF/CTSL	3
GO:0005518	collagen binding	5/975	69/18367	0.303622228076302	0.645611312749596	COL14A1/ITGB1/ADGRG1/CTSL/SERPINH1	5
GO:0001217	DNA-binding transcription repressor activity	19/975	313/18367	0.30598282304719	0.645611312749596	JUN/PEG3/NFE2L3/ENO1/ZFHX3/LRRFIP1/HIC2/TBX3/BHLHE41/IRX2/NR3C1/FOXP1/SMAD5/TFAP2A/YY1/NR2F6/REST/GATA3/HES1	19
GO:0005243	gap junction channel activity	2/975	21/18367	0.307467158663685	0.645611312749596	GJA1/GJA5	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/975	21/18367	0.307467158663685	0.645611312749596	SLC25A6/SLC19A1	2
GO:0015662	P-type ion transporter activity	2/975	21/18367	0.307467158663685	0.645611312749596	ATP2B1/ATP2B4	2
GO:0051010	microtubule plus-end binding	2/975	21/18367	0.307467158663685	0.645611312749596	CLIP1/DST	2
GO:0140358	P-type transmembrane transporter activity	2/975	21/18367	0.307467158663685	0.645611312749596	ATP2B1/ATP2B4	2
GO:0005253	anion channel activity	6/975	87/18367	0.315353701479707	0.660673139299114	CLIC3/GABRE/CLDN4/CLIC1/VDAC1/VDAC2	6
GO:0051219	phosphoprotein binding	6/975	88/18367	0.324812673649079	0.664677709587944	PFN1/RASA1/PIK3R1/RTF1/THRAP3/YWHAE	6
GO:0000062	fatty-acyl-CoA binding	2/975	22/18367	0.327357873507041	0.664677709587944	HADHA/ACBD3	2
GO:0005355	glucose transmembrane transporter activity	2/975	22/18367	0.327357873507041	0.664677709587944	SLC2A1/SLC5A3	2
GO:0005416	amino acid:cation symporter activity	2/975	22/18367	0.327357873507041	0.664677709587944	SLC38A1/SLC38A2	2
GO:0005537	mannose binding	2/975	22/18367	0.327357873507041	0.664677709587944	LMAN1/MANBA	2
GO:0008093	cytoskeletal anchor activity	2/975	22/18367	0.327357873507041	0.664677709587944	ANK3/OBSL1	2
GO:0008320	protein transmembrane transporter activity	2/975	22/18367	0.327357873507041	0.664677709587944	MCL1/ABCA1	2
GO:0015149	hexose transmembrane transporter activity	2/975	22/18367	0.327357873507041	0.664677709587944	SLC2A1/SLC5A3	2
GO:0015296	anion:cation symporter activity	2/975	22/18367	0.327357873507041	0.664677709587944	SLC13A4/SLC6A4	2
GO:0030742	GTP-dependent protein binding	2/975	22/18367	0.327357873507041	0.664677709587944	EEA1/CDC42	2
GO:0050321	tau-protein kinase activity	2/975	22/18367	0.327357873507041	0.664677709587944	ROCK1/TAOK1	2
GO:0120020	cholesterol transfer activity	2/975	22/18367	0.327357873507041	0.664677709587944	ABCA1/NPC2	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3/975	38/18367	0.328032087777204	0.664677709587944	NKTR/PPIA/PPIG	3
GO:0004520	endodeoxyribonuclease activity	3/975	38/18367	0.328032087777204	0.664677709587944	RPS3/RAD50/DICER1	3
GO:0008395	steroid hydroxylase activity	3/975	38/18367	0.328032087777204	0.664677709587944	CYP2J2/CYP11A1/CYP19A1	3
GO:0016853	isomerase activity	10/975	158/18367	0.329847059875059	0.666896020620753	CYP2J2/TPI1/MIF/NKTR/PPIA/PTGES3/PPIG/PDIA3/P4HB/PGAM1	10
GO:0140097	catalytic activity, acting on DNA	14/975	229/18367	0.331930392898989	0.669646064977045	BPTF/ATRX/RPS3/ANXA1/PTGES3/SMARCA2/CHD2/RAD50/DICER1/CHD4/CHD8/DNMT3A/SETX/CHD6	14
GO:0005080	protein kinase C binding	4/975	55/18367	0.33416980438686	0.671520377368489	ITGAV/DSP/HSPB1/SRSF2	4
GO:0015297	antiporter activity	6/975	89/18367	0.334309820698567	0.671520377368489	SLC26A2/SLC9A1/SLC25A6/SLC7A6/SLC3A2/SLC19A1	6
GO:0000049	tRNA binding	5/975	72/18367	0.335350018296315	0.672151768273566	EEF1A1/NEMF/IARS2/EIF2AK4/SSB	5
GO:0051087	chaperone binding	7/975	107/18367	0.340822610312262	0.681645220624524	LRP2/HSPA5/GRN/CTSC/PTGES3/DNAJB1/HES1	7
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	3/975	39/18367	0.34280666142143	0.68413570792294	IQGAP2/IQGAP1/ZFYVE16	3
GO:0004869	cysteine-type endopeptidase inhibitor activity	4/975	56/18367	0.346403703435556	0.686764625015995	SERPINB9/BIRC6/CSTB/PTTG1	4
GO:0120015	sterol transfer activity	2/975	23/18367	0.347090544824499	0.686764625015995	ABCA1/NPC2	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/975	23/18367	0.347090544824499	0.686764625015995	C1GALT1/FUT8	2
GO:1901567	fatty acid derivative binding	2/975	23/18367	0.347090544824499	0.686764625015995	HADHA/ACBD3	2
GO:0016407	acetyltransferase activity	6/975	91/18367	0.353393422846624	0.69767207230529	NCOA3/USP22/HGSNAT/EP300/HADHA/TAF9	6
GO:0005525	GTP binding	22/975	377/18367	0.354110015100957	0.69767207230529	EEF1A1/RHOB/TUBA1C/TUBA1B/RAN/GNAQ/RAB11A/ARHGAP5/RHOA/RAB6A/GNA12/TUBB4B/RHOBTB3/CDC42/KRAS/ARL4A/RAB17/OLA1/ARF4/RHOC/TUBB6/RAB25	22
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	3/975	40/18367	0.357553957696216	0.699989354813311	CYP2J2/CYP19A1/HMOX1	3
GO:0031492	nucleosomal DNA binding	3/975	40/18367	0.357553957696216	0.699989354813311	CHD4/HMGN3/HNRNPC	3
GO:0043014	alpha-tubulin binding	3/975	40/18367	0.357553957696216	0.699989354813311	SETD2/EML4/TAOK1	3
GO:0015145	monosaccharide transmembrane transporter activity	2/975	24/18367	0.36662592267774	0.705710733308253	SLC2A1/SLC5A3	2
GO:0019789	SUMO transferase activity	2/975	24/18367	0.36662592267774	0.705710733308253	RANBP2/ZNF451	2
GO:0043495	protein-membrane adaptor activity	2/975	24/18367	0.36662592267774	0.705710733308253	SYNE2/PDCD6	2
GO:0070003	threonine-type peptidase activity	2/975	24/18367	0.36662592267774	0.705710733308253	PSMB3/PSMB7	2
GO:0070840	dynein complex binding	2/975	24/18367	0.36662592267774	0.705710733308253	TPR/ATMIN	2
GO:0000149	SNARE binding	7/975	110/18367	0.367040764071902	0.705710733308253	SYT7/RAB11A/ABCA1/SLC6A4/UVRAG/VAMP2/VAMP3	7
GO:0019001	guanyl nucleotide binding	23/975	398/18367	0.367231394533165	0.705710733308253	EEF1A1/RHOB/TUBA1C/TUBA1B/RAN/GNAQ/RAB11A/ARHGAP5/RHOA/RAB6A/GNA12/TUBB4B/RHOBTB3/CDC42/KRAS/SLC19A1/ARL4A/RAB17/OLA1/ARF4/RHOC/TUBB6/RAB25	23
GO:0032561	guanyl ribonucleotide binding	23/975	398/18367	0.367231394533165	0.705710733308253	EEF1A1/RHOB/TUBA1C/TUBA1B/RAN/GNAQ/RAB11A/ARHGAP5/RHOA/RAB6A/GNA12/TUBB4B/RHOBTB3/CDC42/KRAS/SLC19A1/ARL4A/RAB17/OLA1/ARF4/RHOC/TUBB6/RAB25	23
GO:0019003	GDP binding	5/975	75/18367	0.367335392499544	0.705710733308253	RHOB/RAN/RHOA/KRAS/RAB17	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	4/975	58/18367	0.370880382011173	0.709847519107244	GSTO1/GSTP1/GSTA3/NANS	4
GO:0016859	cis-trans isomerase activity	3/975	41/18367	0.372254116900434	0.709847519107244	NKTR/PPIA/PPIG	3
GO:0048487	beta-tubulin binding	3/975	41/18367	0.372254116900434	0.709847519107244	EML4/TAOK1/UXT	3
GO:0072341	modified amino acid binding	6/975	93/18367	0.372554961432096	0.709847519107244	ANXA2/TLN1/SCIN/SYT7/MME/SLC19A1	6
GO:0016410	N-acyltransferase activity	6/975	94/18367	0.382149906213145	0.722591426107604	NCOA3/USP22/HGSNAT/NMT1/EP300/TAF9	6
GO:0008327	methyl-CpG binding	2/975	25/18367	0.385929361069023	0.722591426107604	ZBTB38/PRMT1	2
GO:0035925	mRNA 3'-UTR AU-rich region binding	2/975	25/18367	0.385929361069023	0.722591426107604	ZFP36L1/TIA1	2
GO:0120227	acyl-CoA binding	2/975	25/18367	0.385929361069023	0.722591426107604	HADHA/ACBD3	2
GO:0019205	nucleobase-containing compound kinase activity	3/975	42/18367	0.386888458855439	0.722591426107604	N4BP2/DLG1/AK2	3
GO:0003724	RNA helicase activity	5/975	77/18367	0.388690097653531	0.722591426107604	DDX5/DDX17/DDX39B/DDX46/DDX24	5
GO:0015291	secondary active transmembrane transporter activity	14/975	240/18367	0.397373311535909	0.722591426107604	SLC26A2/SLC38A1/SLC38A2/SLC5A3/SLC16A12/SLC9A1/SLC1A5/SLC13A4/SLC6A4/SLC25A6/SLC7A6/SLC3A2/SLC19A1/SLC13A3	14
GO:0008198	ferrous iron binding	2/975	26/18367	0.404970440593826	0.722591426107604	FTH1/TET2	2
GO:0030371	translation repressor activity	2/975	26/18367	0.404970440593826	0.722591426107604	PURA/CELF1	2
GO:0008186	ATP-dependent activity, acting on RNA	5/975	79/18367	0.409996100208022	0.722591426107604	DDX5/DDX17/DDX39B/DDX46/DDX24	5
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	10/975	170/18367	0.415835339141705	0.722591426107604	CYP2J2/CYP11A1/TET2/CYP19A1/KDM5A/KDM5B/ASPH/KDM2A/P4HB/HMOX1	10
GO:0001784	phosphotyrosine residue binding	3/975	44/18367	0.415890767559892	0.722591426107604	PFN1/RASA1/PIK3R1	3
GO:0015103	inorganic anion transmembrane transporter activity	9/975	152/18367	0.417297801317082	0.722591426107604	SLC26A2/CLIC3/GABRE/CLDN4/SLC13A4/CLIC1/SLC6A4/VDAC1/VDAC2	9
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	1/975	10/18367	0.420500139315727	0.722591426107604	RAD50	1
GO:0001094	TFIID-class transcription factor complex binding	1/975	10/18367	0.420500139315727	0.722591426107604	EDF1	1
GO:0004300	enoyl-CoA hydratase activity	1/975	10/18367	0.420500139315727	0.722591426107604	HADHA	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	1/975	10/18367	0.420500139315727	0.722591426107604	AKAP13	1
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	1/975	10/18367	0.420500139315727	0.722591426107604	PTPN12	1
GO:0004955	prostaglandin receptor activity	1/975	10/18367	0.420500139315727	0.722591426107604	HPGD	1
GO:0005432	calcium:sodium antiporter activity	1/975	10/18367	0.420500139315727	0.722591426107604	SLC3A2	1
GO:0005522	profilin binding	1/975	10/18367	0.420500139315727	0.722591426107604	ACTG1	1
GO:0008097	5S rRNA binding	1/975	10/18367	0.420500139315727	0.722591426107604	RPL11	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	1/975	10/18367	0.420500139315727	0.722591426107604	SLC35B4	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/975	10/18367	0.420500139315727	0.722591426107604	SLC3A2	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1/975	10/18367	0.420500139315727	0.722591426107604	CYB5R1	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/975	10/18367	0.420500139315727	0.722591426107604	PGAM1	1
GO:0019531	oxalate transmembrane transporter activity	1/975	10/18367	0.420500139315727	0.722591426107604	SLC26A2	1
GO:0019869	chloride channel inhibitor activity	1/975	10/18367	0.420500139315727	0.722591426107604	WNK1	1
GO:0030957	Tat protein binding	1/975	10/18367	0.420500139315727	0.722591426107604	NPM1	1
GO:0031419	cobalamin binding	1/975	10/18367	0.420500139315727	0.722591426107604	MTR	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/975	10/18367	0.420500139315727	0.722591426107604	SLC27A2	1
GO:0032356	oxidized DNA binding	1/975	10/18367	0.420500139315727	0.722591426107604	RPS3	1
GO:0035612	AP-2 adaptor complex binding	1/975	10/18367	0.420500139315727	0.722591426107604	AAK1	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/975	10/18367	0.420500139315727	0.722591426107604	PIK3R1	1
GO:0043208	glycosphingolipid binding	1/975	10/18367	0.420500139315727	0.722591426107604	PSAP	1
GO:0045294	alpha-catenin binding	1/975	10/18367	0.420500139315727	0.722591426107604	VCL	1
GO:0045503	dynein light chain binding	1/975	10/18367	0.420500139315727	0.722591426107604	HOOK3	1
GO:0050786	RAGE receptor binding	1/975	10/18367	0.420500139315727	0.722591426107604	S100A9	1
GO:0051864	histone H3-methyl-lysine-36 demethylase activity	1/975	10/18367	0.420500139315727	0.722591426107604	KDM2A	1
GO:0051880	G-quadruplex DNA binding	1/975	10/18367	0.420500139315727	0.722591426107604	RAD50	1
GO:0070008	serine-type exopeptidase activity	1/975	10/18367	0.420500139315727	0.722591426107604	CPD	1
GO:0070567	cytidylyltransferase activity	1/975	10/18367	0.420500139315727	0.722591426107604	NANS	1
GO:0098505	G-rich strand telomeric DNA binding	1/975	10/18367	0.420500139315727	0.722591426107604	HNRNPA1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/975	10/18367	0.420500139315727	0.722591426107604	ADRB1	1
GO:0001671	ATPase activator activity	2/975	27/18367	0.423722618117094	0.722591426107604	DNAJB1/DNAJC15	2
GO:0004190	aspartic-type endopeptidase activity	2/975	27/18367	0.423722618117094	0.722591426107604	CTSD/SPPL3	2
GO:0004709	MAP kinase kinase kinase activity	2/975	27/18367	0.423722618117094	0.722591426107604	EGFR/MAP3K4	2
GO:0015491	cation:cation antiporter activity	2/975	27/18367	0.423722618117094	0.722591426107604	SLC9A1/SLC3A2	2
GO:0016405	CoA-ligase activity	2/975	27/18367	0.423722618117094	0.722591426107604	ACSS1/SLC27A2	2
GO:0016866	intramolecular transferase activity	2/975	27/18367	0.423722618117094	0.722591426107604	CYP2J2/PGAM1	2
GO:0022884	macromolecule transmembrane transporter activity	2/975	27/18367	0.423722618117094	0.722591426107604	MCL1/ABCA1	2
GO:0023026	MHC class II protein complex binding	2/975	27/18367	0.423722618117094	0.722591426107604	PKM/YWHAE	2
GO:0030507	spectrin binding	2/975	27/18367	0.423722618117094	0.722591426107604	ANK3/CAMSAP2	2
GO:0035255	ionotropic glutamate receptor binding	2/975	27/18367	0.423722618117094	0.722591426107604	FUS/FLOT2	2
GO:0051119	sugar transmembrane transporter activity	2/975	27/18367	0.423722618117094	0.722591426107604	SLC2A1/SLC5A3	2
GO:0051393	alpha-actinin binding	2/975	27/18367	0.423722618117094	0.722591426107604	DAG1/PDLIM2	2
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	2/975	27/18367	0.423722618117094	0.722591426107604	ABCA1/ATP10D	2
GO:0048156	tau protein binding	3/975	45/18367	0.430227106181159	0.730567477392689	ROCK1/TAOK1/EP300	3
GO:0015101	organic cation transmembrane transporter activity	2/975	28/18367	0.442162901671867	0.730567477392689	ATP13A3/SLC19A3	2
GO:0070001	aspartic-type peptidase activity	2/975	28/18367	0.442162901671867	0.730567477392689	CTSD/SPPL3	2
GO:1990756	ubiquitin ligase-substrate adaptor activity	2/975	28/18367	0.442162901671867	0.730567477392689	SKP1/PDCD6	2
GO:0016836	hydro-lyase activity	4/975	64/18367	0.443561324429035	0.730567477392689	ENO1/HACD3/CDYL/HADHA	4
GO:0140296	general transcription initiation factor binding	3/975	46/18367	0.444434319746442	0.730567477392689	BDP1/EDF1/HNRNPU	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	9/975	156/18367	0.447819655337777	0.730567477392689	ASH1L/KMT2C/SETD2/NSD1/DNMT3A/SETD5/RNMT/LCMT1/PRMT1	9
GO:0000774	adenyl-nucleotide exchange factor activity	1/975	11/18367	0.451279262493108	0.730567477392689	PFN1	1
GO:0004954	prostanoid receptor activity	1/975	11/18367	0.451279262493108	0.730567477392689	HPGD	1
GO:0005347	ATP transmembrane transporter activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC25A6	1
GO:0008199	ferric iron binding	1/975	11/18367	0.451279262493108	0.730567477392689	FTH1	1
GO:0008503	benzodiazepine receptor activity	1/975	11/18367	0.451279262493108	0.730567477392689	GABRE	1
GO:0015368	calcium:cation antiporter activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC3A2	1
GO:0015378	sodium:chloride symporter activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC6A4	1
GO:0015386	potassium:proton antiporter activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC9A1	1
GO:0016273	arginine N-methyltransferase activity	1/975	11/18367	0.451279262493108	0.730567477392689	PRMT1	1
GO:0016274	protein-arginine N-methyltransferase activity	1/975	11/18367	0.451279262493108	0.730567477392689	PRMT1	1
GO:0016832	aldehyde-lyase activity	1/975	11/18367	0.451279262493108	0.730567477392689	ALDOA	1
GO:0019107	myristoyltransferase activity	1/975	11/18367	0.451279262493108	0.730567477392689	NMT1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/975	11/18367	0.451279262493108	0.730567477392689	DLG1	1
GO:0031996	thioesterase binding	1/975	11/18367	0.451279262493108	0.730567477392689	CDC42	1
GO:0032052	bile acid binding	1/975	11/18367	0.451279262493108	0.730567477392689	PYGL	1
GO:0042608	T cell receptor binding	1/975	11/18367	0.451279262493108	0.730567477392689	EPS8L1	1
GO:0047676	arachidonate-CoA ligase activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC27A2	1
GO:0051400	BH domain binding	1/975	11/18367	0.451279262493108	0.730567477392689	MCL1	1
GO:0070513	death domain binding	1/975	11/18367	0.451279262493108	0.730567477392689	MCL1	1
GO:0097157	pre-mRNA intronic binding	1/975	11/18367	0.451279262493108	0.730567477392689	EP300	1
GO:0097371	MDM2/MDM4 family protein binding	1/975	11/18367	0.451279262493108	0.730567477392689	RPS20	1
GO:1901474	azole transmembrane transporter activity	1/975	11/18367	0.451279262493108	0.730567477392689	SLC19A3	1
GO:0005044	scavenger receptor activity	3/975	47/18367	0.458499306788917	0.73966961339118	LRP1/COLEC12/LGALS3BP	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	3/975	47/18367	0.458499306788917	0.73966961339118	DUSP6/DUSP1/CDKN3	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	2/975	29/18367	0.460271548893921	0.73995044145099	DHCR24/AKR1B1	2
GO:0035250	UDP-galactosyltransferase activity	2/975	29/18367	0.460271548893921	0.73995044145099	B4GALT5/B3GNT2	2
GO:0070888	E-box binding	3/975	48/18367	0.472409995259325	0.741456216100969	BHLHE41/GATA3/HES1	3
GO:0015294	solute:cation symporter activity	6/975	104/18367	0.477293793504283	0.741456216100969	SLC38A1/SLC38A2/SLC5A3/SLC13A4/SLC6A4/SLC13A3	6
GO:0017147	Wnt-protein binding	2/975	30/18367	0.478031787413695	0.741456216100969	WLS/LRP5	2
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	1/975	12/18367	0.480425194017907	0.741456216100969	RPS3	1
GO:0003964	RNA-directed DNA polymerase activity	1/975	12/18367	0.480425194017907	0.741456216100969	PTGES3	1
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	1/975	12/18367	0.480425194017907	0.741456216100969	AKR1B1	1
GO:0005165	neurotrophin receptor binding	1/975	12/18367	0.480425194017907	0.741456216100969	PIK3R1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	1/975	12/18367	0.480425194017907	0.741456216100969	SLC35B4	1
GO:0008174	mRNA methyltransferase activity	1/975	12/18367	0.480425194017907	0.741456216100969	RNMT	1
GO:0008429	phosphatidylethanolamine binding	1/975	12/18367	0.480425194017907	0.741456216100969	NF1	1
GO:0015166	polyol transmembrane transporter activity	1/975	12/18367	0.480425194017907	0.741456216100969	SLC5A3	1
GO:0015269	calcium-activated potassium channel activity	1/975	12/18367	0.480425194017907	0.741456216100969	KCNN4	1
GO:0022858	alanine transmembrane transporter activity	1/975	12/18367	0.480425194017907	0.741456216100969	SLC3A2	1
GO:0030955	potassium ion binding	1/975	12/18367	0.480425194017907	0.741456216100969	PKM	1
GO:0031543	peptidyl-proline dioxygenase activity	1/975	12/18367	0.480425194017907	0.741456216100969	P4HB	1
GO:0033130	acetylcholine receptor binding	1/975	12/18367	0.480425194017907	0.741456216100969	LY6E	1
GO:0034452	dynactin binding	1/975	12/18367	0.480425194017907	0.741456216100969	HOOK3	1
GO:0035325	Toll-like receptor binding	1/975	12/18367	0.480425194017907	0.741456216100969	S100A9	1
GO:0042975	peroxisome proliferator activated receptor binding	1/975	12/18367	0.480425194017907	0.741456216100969	HMGA1	1
GO:0043176	amine binding	1/975	12/18367	0.480425194017907	0.741456216100969	SLC6A4	1
GO:0043422	protein kinase B binding	1/975	12/18367	0.480425194017907	0.741456216100969	SRSF5	1
GO:0051378	serotonin binding	1/975	12/18367	0.480425194017907	0.741456216100969	SLC6A4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/975	12/18367	0.480425194017907	0.741456216100969	USP27X	1
GO:0097677	STAT family protein binding	1/975	12/18367	0.480425194017907	0.741456216100969	EP300	1
GO:0003684	damaged DNA binding	4/975	68/18367	0.490600586844814	0.746715390166679	RPS3/DDB1/EP300/XPC	4
GO:0008194	UDP-glycosyltransferase activity	8/975	143/18367	0.491314766210302	0.746715390166679	EXTL2/GALNT11/CHPF/GCNT2/B4GALT5/HEXA/B3GNT2/GALNT1	8
GO:0000146	microfilament motor activity	2/975	31/18367	0.495429555727847	0.746715390166679	MYH10/MYL6	2
GO:0008157	protein phosphatase 1 binding	2/975	31/18367	0.495429555727847	0.746715390166679	PPP1R15A/PPP1R9A	2
GO:0016878	acid-thiol ligase activity	2/975	31/18367	0.495429555727847	0.746715390166679	ACSS1/SLC27A2	2
GO:0042910	xenobiotic transmembrane transporter activity	2/975	31/18367	0.495429555727847	0.746715390166679	SLC2A1/SLC19A1	2
GO:0071813	lipoprotein particle binding	2/975	31/18367	0.495429555727847	0.746715390166679	ABCA1/COLEC12	2
GO:0071814	protein-lipid complex binding	2/975	31/18367	0.495429555727847	0.746715390166679	ABCA1/COLEC12	2
GO:0015293	symporter activity	8/975	144/18367	0.499257641226491	0.746715390166679	SLC38A1/SLC38A2/SLC5A3/SLC16A12/SLC1A5/SLC13A4/SLC6A4/SLC13A3	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	8/975	144/18367	0.499257641226491	0.746715390166679	GANAB/AGL/GAA/MANBA/MAN2A1/MAN1A2/HEXA/NAGLU	8
GO:0002161	aminoacyl-tRNA editing activity	1/975	13/18367	0.508024509508648	0.746715390166679	IARS2	1
GO:0004000	adenosine deaminase activity	1/975	13/18367	0.508024509508648	0.746715390166679	ADAR	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	1/975	13/18367	0.508024509508648	0.746715390166679	PPP1R14B	1
GO:0005542	folic acid binding	1/975	13/18367	0.508024509508648	0.746715390166679	SLC19A1	1
GO:0008035	high-density lipoprotein particle binding	1/975	13/18367	0.508024509508648	0.746715390166679	ABCA1	1
GO:0008195	phosphatidate phosphatase activity	1/975	13/18367	0.508024509508648	0.746715390166679	PLPP3	1
GO:0008417	fucosyltransferase activity	1/975	13/18367	0.508024509508648	0.746715390166679	FUT8	1
GO:0015385	sodium:proton antiporter activity	1/975	13/18367	0.508024509508648	0.746715390166679	SLC9A1	1
GO:0016594	glycine binding	1/975	13/18367	0.508024509508648	0.746715390166679	GLDC	1
GO:0022851	GABA-gated chloride ion channel activity	1/975	13/18367	0.508024509508648	0.746715390166679	GABRE	1
GO:0031404	chloride ion binding	1/975	13/18367	0.508024509508648	0.746715390166679	CTSC	1
GO:0032036	myosin heavy chain binding	1/975	13/18367	0.508024509508648	0.746715390166679	MYL12B	1
GO:0032454	histone H3-methyl-lysine-9 demethylase activity	1/975	13/18367	0.508024509508648	0.746715390166679	JMJD1C	1
GO:0034236	protein kinase A catalytic subunit binding	1/975	13/18367	0.508024509508648	0.746715390166679	EZR	1
GO:0045159	myosin II binding	1/975	13/18367	0.508024509508648	0.746715390166679	TRIOBP	1
GO:0052650	NADP-retinol dehydrogenase activity	1/975	13/18367	0.508024509508648	0.746715390166679	AKR1B1	1
GO:0060590	ATPase regulator activity	1/975	13/18367	0.508024509508648	0.746715390166679	PFN1	1
GO:0061133	endopeptidase activator activity	1/975	13/18367	0.508024509508648	0.746715390166679	PSME2	1
GO:0070700	BMP receptor binding	1/975	13/18367	0.508024509508648	0.746715390166679	BMP7	1
GO:0140299	small molecule sensor activity	1/975	13/18367	0.508024509508648	0.746715390166679	EFHD1	1
GO:0001222	transcription corepressor binding	2/975	32/18367	0.512453263167486	0.750538422316402	MTF2/NEK6	2
GO:0031624	ubiquitin conjugating enzyme binding	2/975	32/18367	0.512453263167486	0.750538422316402	SIAH1/SIAH2	2
GO:0004860	protein kinase inhibitor activity	4/975	70/18367	0.513497974492698	0.750538422316402	HSPB1/NPM1/TAOK3/WNK1	4
GO:0043178	alcohol binding	5/975	89/18367	0.513867559123757	0.750538422316402	CAV1/ABCA1/VDAC1/NPC2/VDAC2	5
GO:0042626	ATPase-coupled transmembrane transporter activity	6/975	109/18367	0.523332390960485	0.763158730754975	SLC26A2/ATP2B1/ATP2B4/ATP13A3/ABCA1/ATP6V0E1	6
GO:0016830	carbon-carbon lyase activity	3/975	52/18367	0.526302420488006	0.763320090887043	ALDOA/PISD/PDXDC1	3
GO:0019956	chemokine binding	2/975	33/18367	0.52909356766909	0.763320090887043	ITGAV/ITGB1	2
GO:0008047	enzyme activator activity	6/975	110/18367	0.532349215588672	0.763320090887043	PSAP/CALM1/RAB3GAP2/MMP15/CFLAR/CALM2	6
GO:0004707	MAP kinase activity	1/975	14/18367	0.534159199670414	0.763320090887043	MAPK14	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/975	14/18367	0.534159199670414	0.763320090887043	PIK3R1	1
GO:0005451	monovalent cation:proton antiporter activity	1/975	14/18367	0.534159199670414	0.763320090887043	SLC9A1	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/975	14/18367	0.534159199670414	0.763320090887043	B3GNT2	1
GO:0015562	efflux transmembrane transporter activity	1/975	14/18367	0.534159199670414	0.763320090887043	GJA1	1
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	1/975	14/18367	0.534159199670414	0.763320090887043	MIF	1
GO:0030983	mismatched DNA binding	1/975	14/18367	0.534159199670414	0.763320090887043	XPC	1
GO:0035259	glucocorticoid receptor binding	1/975	14/18367	0.534159199670414	0.763320090887043	NRIP1	1
GO:0036041	long-chain fatty acid binding	1/975	14/18367	0.534159199670414	0.763320090887043	S100A9	1
GO:0070411	I-SMAD binding	1/975	14/18367	0.534159199670414	0.763320090887043	SMAD5	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3/975	53/18367	0.539294128399123	0.76915060254833	SLC25A6/SLC35B4/SLC19A1	3
GO:0016831	carboxy-lyase activity	2/975	34/18367	0.5453431701374	0.76915060254833	PISD/PDXDC1	2
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	2/975	34/18367	0.5453431701374	0.76915060254833	DICER1/AGO2	2
GO:0030291	protein serine/threonine kinase inhibitor activity	2/975	34/18367	0.5453431701374	0.76915060254833	HSPB1/WNK1	2
GO:0140677	molecular function activator activity	8/975	150/18367	0.546045109747137	0.76915060254833	PSAP/DNAJB1/CALM1/RAB3GAP2/MMP15/CFLAR/CALM2/DNAJC15	8
GO:0106306	protein serine phosphatase activity	4/975	73/18367	0.546919241977093	0.76915060254833	DUSP6/DUSP1/CTDSPL/CDKN3	4
GO:0106307	protein threonine phosphatase activity	4/975	73/18367	0.546919241977093	0.76915060254833	DUSP6/DUSP1/CTDSPL/CDKN3	4
GO:0005254	chloride channel activity	4/975	74/18367	0.557791243137035	0.76915060254833	CLIC3/GABRE/CLDN4/CLIC1	4
GO:0019210	kinase inhibitor activity	4/975	74/18367	0.557791243137035	0.76915060254833	HSPB1/NPM1/TAOK3/WNK1	4
GO:0001846	opsonin binding	1/975	15/18367	0.55890691286833	0.76915060254833	ITGAV	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	1/975	15/18367	0.55890691286833	0.76915060254833	PDE4B	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/975	15/18367	0.55890691286833	0.76915060254833	SLC27A2	1
GO:0004953	icosanoid receptor activity	1/975	15/18367	0.55890691286833	0.76915060254833	HPGD	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/975	15/18367	0.55890691286833	0.76915060254833	GABRE	1
GO:0030280	structural constituent of skin epidermis	1/975	15/18367	0.55890691286833	0.76915060254833	KRT10	1
GO:0030548	acetylcholine receptor regulator activity	1/975	15/18367	0.55890691286833	0.76915060254833	LY6E	1
GO:0042813	Wnt-activated receptor activity	1/975	15/18367	0.55890691286833	0.76915060254833	LRP5	1
GO:0048185	activin binding	1/975	15/18367	0.55890691286833	0.76915060254833	TGFBR3	1
GO:0051139	metal ion:proton antiporter activity	1/975	15/18367	0.55890691286833	0.76915060254833	SLC9A1	1
GO:0051371	muscle alpha-actinin binding	1/975	15/18367	0.55890691286833	0.76915060254833	PDLIM2	1
GO:0099602	neurotransmitter receptor regulator activity	1/975	15/18367	0.55890691286833	0.76915060254833	LY6E	1
GO:1990825	sequence-specific mRNA binding	1/975	15/18367	0.55890691286833	0.76915060254833	SSB	1
GO:0015298	solute:cation antiporter activity	2/975	35/18367	0.561196624267798	0.76915060254833	SLC9A1/SLC3A2	2
GO:0015081	sodium ion transmembrane transporter activity	8/975	152/18367	0.561252014111009	0.76915060254833	SLC38A1/SLC38A2/SLC5A3/SLC9A1/SLC13A4/SLC6A4/SLC3A2/SLC13A3	8
GO:0030170	pyridoxal phosphate binding	3/975	55/18367	0.564650421032671	0.76915060254833	GLDC/PDXDC1/PYGL	3
GO:0016757	glycosyltransferase activity	14/975	270/18367	0.575138428884398	0.76915060254833	AGL/EXTL2/GALNT11/PARP1/CHPF/GCNT2/C1GALT1/RPN2/FUT8/B4GALT5/HEXA/B3GNT2/PYGL/GALNT1	14
GO:0005484	SNAP receptor activity	2/975	36/18367	0.576650160768958	0.76915060254833	VAMP2/VAMP3	2
GO:0023023	MHC protein complex binding	2/975	36/18367	0.576650160768958	0.76915060254833	PKM/YWHAE	2
GO:0042805	actinin binding	2/975	36/18367	0.576650160768958	0.76915060254833	DAG1/PDLIM2	2
GO:0070279	vitamin B6 binding	3/975	56/18367	0.577004008821187	0.76915060254833	GLDC/PDXDC1/PYGL	3
GO:0015085	calcium ion transmembrane transporter activity	7/975	135/18367	0.58002636061191	0.76915060254833	ATP2B1/ITGAV/ANXA2/ATP2B4/MCOLN3/TRPV6/SLC3A2	7
GO:0035091	phosphatidylinositol binding	14/975	271/18367	0.580770222847543	0.76915060254833	PFN1/IQGAP2/IQGAP1/ANXA2/EEA1/TLN1/ZFYVE16/SCIN/EXOC1/SYT7/SLC9A1/ARHGAP32/SVIL/SNX18	14
GO:0004698	calcium-dependent protein kinase C activity	1/975	16/18367	0.582341184879739	0.76915060254833	PKN2	1
GO:0005402	carbohydrate:cation symporter activity	1/975	16/18367	0.582341184879739	0.76915060254833	SLC5A3	1
GO:0005523	tropomyosin binding	1/975	16/18367	0.582341184879739	0.76915060254833	CALD1	1
GO:0008191	metalloendopeptidase inhibitor activity	1/975	16/18367	0.582341184879739	0.76915060254833	TIMP2	1
GO:0015172	acidic amino acid transmembrane transporter activity	1/975	16/18367	0.582341184879739	0.76915060254833	SLC1A5	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	1/975	16/18367	0.582341184879739	0.76915060254833	DICER1	1
GO:0022821	potassium ion antiporter activity	1/975	16/18367	0.582341184879739	0.76915060254833	SLC9A1	1
GO:0032183	SUMO binding	1/975	16/18367	0.582341184879739	0.76915060254833	HERC2	1
GO:0042577	lipid phosphatase activity	1/975	16/18367	0.582341184879739	0.76915060254833	PLPP3	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	1/975	16/18367	0.582341184879739	0.76915060254833	PIK3R1	1
GO:0050700	CARD domain binding	1/975	16/18367	0.582341184879739	0.76915060254833	CASP4	1
GO:0140327	flippase activity	1/975	16/18367	0.582341184879739	0.76915060254833	ATP10D	1
GO:1990404	protein ADP-ribosylase activity	1/975	16/18367	0.582341184879739	0.76915060254833	PARP1	1
GO:0008168	methyltransferase activity	11/975	214/18367	0.587512743361332	0.76915060254833	ASH1L/KMT2C/SETD2/MTR/NSD1/DNMT3A/SETD5/RNMT/METTL7A/LCMT1/PRMT1	11
GO:0004536	deoxyribonuclease activity	3/975	57/18367	0.589135085754547	0.76915060254833	RPS3/RAD50/DICER1	3
GO:0005109	frizzled binding	2/975	37/18367	0.591701524995268	0.76915060254833	RNF43/ZNRF3	2
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	2/975	37/18367	0.591701524995268	0.76915060254833	GAPDH/AKR1B1	2
GO:0030551	cyclic nucleotide binding	2/975	37/18367	0.591701524995268	0.76915060254833	PDE4B/SLC19A1	2
GO:0042056	chemoattractant activity	2/975	37/18367	0.591701524995268	0.76915060254833	MIF/LGALS3	2
GO:0043531	ADP binding	2/975	37/18367	0.591701524995268	0.76915060254833	MYH10/PGK1	2
GO:0046915	transition metal ion transmembrane transporter activity	2/975	37/18367	0.591701524995268	0.76915060254833	SLC39A10/SLC40A1	2
GO:0071949	FAD binding	2/975	37/18367	0.591701524995268	0.76915060254833	DHCR24/CYB5R1	2
GO:0031406	carboxylic acid binding	9/975	176/18367	0.594030448941325	0.76915060254833	NR2F2/GLDC/PSAP/GSTP1/S100A9/PYGL/RXRA/SLC19A1/SIGLEC6	9
GO:0016829	lyase activity	10/975	196/18367	0.597033245532143	0.76915060254833	ALDOA/TPI1/ENO1/RPS3/GLDC/HACD3/PISD/PDXDC1/CDYL/HADHA	10
GO:0004722	protein serine/threonine phosphatase activity	5/975	98/18367	0.60030699949685	0.76915060254833	DUSP6/DUSP1/CTDSPL/CAMK2G/CDKN3	5
GO:0016791	phosphatase activity	14/975	275/18367	0.602984893050701	0.76915060254833	DUSP6/PLPP3/DUSP1/DLG1/PTPN14/PHPT1/PTPRF/CTDSPL/PTPRA/PTPN12/PTPRE/TNS3/CAMK2G/CDKN3	14
GO:0005005	transmembrane-ephrin receptor activity	1/975	17/18367	0.604531656502117	0.76915060254833	EPHB4	1
GO:0008392	arachidonic acid epoxygenase activity	1/975	17/18367	0.604531656502117	0.76915060254833	CYP2J2	1
GO:0008484	sulfuric ester hydrolase activity	1/975	17/18367	0.604531656502117	0.76915060254833	GNS	1
GO:0008525	phosphatidylcholine transporter activity	1/975	17/18367	0.604531656502117	0.76915060254833	ABCA1	1
GO:0008574	plus-end-directed microtubule motor activity	1/975	17/18367	0.604531656502117	0.76915060254833	KIF5B	1
GO:0015108	chloride transmembrane transporter activity	1/975	17/18367	0.604531656502117	0.76915060254833	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/975	17/18367	0.604531656502117	0.76915060254833	SLC7A6	1
GO:0015278	calcium-release channel activity	1/975	17/18367	0.604531656502117	0.76915060254833	MCOLN3	1
GO:0015377	cation:chloride symporter activity	1/975	17/18367	0.604531656502117	0.76915060254833	SLC6A4	1
GO:0016722	oxidoreductase activity, acting on metal ions	1/975	17/18367	0.604531656502117	0.76915060254833	FTH1	1
GO:0017081	chloride channel regulator activity	1/975	17/18367	0.604531656502117	0.76915060254833	WNK1	1
GO:0030169	low-density lipoprotein particle binding	1/975	17/18367	0.604531656502117	0.76915060254833	COLEC12	1
GO:0031420	alkali metal ion binding	1/975	17/18367	0.604531656502117	0.76915060254833	PKM	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	1/975	17/18367	0.604531656502117	0.76915060254833	ATP6V0E1	1
GO:0043395	heparan sulfate proteoglycan binding	1/975	17/18367	0.604531656502117	0.76915060254833	LRP1	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1/975	17/18367	0.604531656502117	0.76915060254833	ATP6V0E1	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1/975	17/18367	0.604531656502117	0.76915060254833	ATP6V0E1	1
GO:0050780	dopamine receptor binding	1/975	17/18367	0.604531656502117	0.76915060254833	GNA12	1
GO:0070064	proline-rich region binding	1/975	17/18367	0.604531656502117	0.76915060254833	PFN1	1
GO:0070628	proteasome binding	1/975	17/18367	0.604531656502117	0.76915060254833	ID1	1
GO:0005501	retinoid binding	2/975	38/18367	0.606349827062939	0.76915060254833	NR2F2/RXRA	2
GO:0016251	RNA polymerase II general transcription initiation factor activity	2/975	38/18367	0.606349827062939	0.76915060254833	TAF3/TAF9	2
GO:0019840	isoprenoid binding	2/975	38/18367	0.606349827062939	0.76915060254833	NR2F2/RXRA	2
GO:0140303	intramembrane lipid transporter activity	2/975	38/18367	0.606349827062939	0.76915060254833	ABCA1/ATP10D	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/975	39/18367	0.620595403584101	0.782775679680144	POLR2J3/POLR2A	2
GO:0005504	fatty acid binding	2/975	39/18367	0.620595403584101	0.782775679680144	GSTP1/S100A9	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/975	39/18367	0.620595403584101	0.782775679680144	DLG1/AK2	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3/975	60/18367	0.624158720298014	0.782775679680144	DHCR24/AKR1B1/SDHC	3
GO:0004708	MAP kinase kinase activity	1/975	18/18367	0.625544279657999	0.782775679680144	MAPK14	1
GO:0008301	DNA binding, bending	1/975	18/18367	0.625544279657999	0.782775679680144	HMGB3	1
GO:0008569	minus-end-directed microtubule motor activity	1/975	18/18367	0.625544279657999	0.782775679680144	DYNC1H1	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/975	18/18367	0.625544279657999	0.782775679680144	CDC42	1
GO:0099095	ligand-gated anion channel activity	1/975	18/18367	0.625544279657999	0.782775679680144	GABRE	1
GO:1904047	S-adenosyl-L-methionine binding	1/975	18/18367	0.625544279657999	0.782775679680144	PRMT1	1
GO:0000287	magnesium ion binding	11/975	221/18367	0.630352159411004	0.787727529844251	PKM/ENO1/S100P/RAN/RPS6KA5/ATP10D/MAST4/WNK1/NEK6/IDH1/PDCD6	11
GO:0015144	carbohydrate transmembrane transporter activity	2/975	40/18367	0.634439690209779	0.79070141740815	SLC2A1/SLC5A3	2
GO:0042169	SH2 domain binding	2/975	40/18367	0.634439690209779	0.79070141740815	DAG1/ARHGAP5	2
GO:0005507	copper ion binding	3/975	61/18367	0.635368228015733	0.790794326804527	F5/SOD3/GPC1	3
GO:0004890	GABA-A receptor activity	1/975	19/18367	0.645441512604396	0.797969079668453	GABRE	1
GO:0005003	ephrin receptor activity	1/975	19/18367	0.645441512604396	0.797969079668453	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/975	19/18367	0.645441512604396	0.797969079668453	SLC6A4	1
GO:0030627	pre-mRNA 5'-splice site binding	1/975	19/18367	0.645441512604396	0.797969079668453	SNRPC	1
GO:0035613	RNA stem-loop binding	1/975	19/18367	0.645441512604396	0.797969079668453	MYH10	1
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/975	41/18367	0.647885104225643	0.798856999351458	ACSS1/SLC27A2	2
GO:0030020	extracellular matrix structural constituent conferring tensile strength	2/975	41/18367	0.647885104225643	0.798856999351458	COL14A1/COL4A2	2
GO:0016741	transferase activity, transferring one-carbon groups	11/975	225/18367	0.65376885745173	0.805039843085508	ASH1L/KMT2C/SETD2/MTR/NSD1/DNMT3A/SETD5/RNMT/METTL7A/LCMT1/PRMT1	11
GO:0008137	NADH dehydrogenase (ubiquinone) activity	2/975	42/18367	0.660934936494153	0.807251442867821	NDUFA13/NDUFA6	2
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	1/975	20/18367	0.664282504822116	0.807251442867821	ATP6V0E1	1
GO:0016408	C-acyltransferase activity	1/975	20/18367	0.664282504822116	0.807251442867821	HADHA	1
GO:0016505	peptidase activator activity involved in apoptotic process	1/975	20/18367	0.664282504822116	0.807251442867821	CTSC	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/975	20/18367	0.664282504822116	0.807251442867821	GLDC	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/975	20/18367	0.664282504822116	0.807251442867821	GNPTAB	1
GO:0030296	protein tyrosine kinase activator activity	1/975	20/18367	0.664282504822116	0.807251442867821	CD24	1
GO:0031690	adrenergic receptor binding	1/975	20/18367	0.664282504822116	0.807251442867821	ADRB1	1
GO:0035014	phosphatidylinositol 3-kinase regulator activity	1/975	20/18367	0.664282504822116	0.807251442867821	PIK3R1	1
GO:0042288	MHC class I protein binding	1/975	20/18367	0.664282504822116	0.807251442867821	TUBB4B	1
GO:0030547	signaling receptor inhibitor activity	2/975	43/18367	0.673593252083244	0.81429158150011	LY6E/LRPAP1	2
GO:0034062	5'-3' RNA polymerase activity	2/975	43/18367	0.673593252083244	0.81429158150011	POLR2J3/POLR2A	2
GO:0050136	NADH dehydrogenase (quinone) activity	2/975	43/18367	0.673593252083244	0.81429158150011	NDUFA13/NDUFA6	2
GO:0097747	RNA polymerase activity	2/975	43/18367	0.673593252083244	0.81429158150011	POLR2J3/POLR2A	2
GO:0005123	death receptor binding	1/975	21/18367	0.682123272130037	0.820238316130022	CFLAR	1
GO:0005385	zinc ion transmembrane transporter activity	1/975	21/18367	0.682123272130037	0.820238316130022	SLC39A10	1
GO:0008391	arachidonic acid monooxygenase activity	1/975	21/18367	0.682123272130037	0.820238316130022	CYP2J2	1
GO:1990381	ubiquitin-specific protease binding	1/975	21/18367	0.682123272130037	0.820238316130022	CLTC	1
GO:0046906	tetrapyrrole binding	7/975	149/18367	0.682941405762685	0.820238316130022	CYP2J2/CYP11A1/CYP19A1/MTR/HMOX1/STC2/SDHC	7
GO:0004712	protein serine/threonine/tyrosine kinase activity	2/975	44/18367	0.685864798965309	0.821433521208944	MAPK14/AURKA	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2/975	44/18367	0.685864798965309	0.821433521208944	GAPDH/AKR1B1	2
GO:0008236	serine-type peptidase activity	9/975	191/18367	0.690246350694414	0.821433521208944	CTSC/CPD/CTSV/MMP14/PCSK7/MBTPS1/HTRA1/DPP4/DPP7	9
GO:0015078	proton transmembrane transporter activity	6/975	130/18367	0.694164094755374	0.821433521208944	COX6A1/UQCRH/SLC9A1/ATP6V0E1/COX5A/COX7B	6
GO:0003954	NADH dehydrogenase activity	2/975	45/18367	0.697754924211083	0.821433521208944	NDUFA13/NDUFA6	2
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	2/975	45/18367	0.697754924211083	0.821433521208944	NDUFA13/NDUFA6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2/975	45/18367	0.697754924211083	0.821433521208944	DICER1/AGO2	2
GO:0140223	general transcription initiation factor activity	2/975	45/18367	0.697754924211083	0.821433521208944	TAF3/TAF9	2
GO:0005540	hyaluronic acid binding	1/975	22/18367	0.699016862540656	0.821433521208944	HMMR	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	1/975	22/18367	0.699016862540656	0.821433521208944	AKR1B1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/975	22/18367	0.699016862540656	0.821433521208944	SLC26A2	1
GO:0015645	fatty acid ligase activity	1/975	22/18367	0.699016862540656	0.821433521208944	SLC27A2	1
GO:0016881	acid-amino acid ligase activity	1/975	22/18367	0.699016862540656	0.821433521208944	GCLM	1
GO:0016917	GABA receptor activity	1/975	22/18367	0.699016862540656	0.821433521208944	GABRE	1
GO:0033691	sialic acid binding	1/975	22/18367	0.699016862540656	0.821433521208944	SIGLEC6	1
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	1/975	22/18367	0.699016862540656	0.821433521208944	SERPINB9	1
GO:0070182	DNA polymerase binding	1/975	22/18367	0.699016862540656	0.821433521208944	PTGES3	1
GO:0017171	serine hydrolase activity	9/975	195/18367	0.713352918931869	0.831787077083338	CTSC/CPD/CTSV/MMP14/PCSK7/MBTPS1/HTRA1/DPP4/DPP7	9
GO:0003950	NAD+ ADP-ribosyltransferase activity	1/975	23/18367	0.715013513345936	0.831787077083338	PARP1	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	1/975	23/18367	0.715013513345936	0.831787077083338	PDE4B	1
GO:0005212	structural constituent of eye lens	1/975	23/18367	0.715013513345936	0.831787077083338	CRYBG3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/975	23/18367	0.715013513345936	0.831787077083338	PKN2	1
GO:0015299	solute:proton antiporter activity	1/975	23/18367	0.715013513345936	0.831787077083338	SLC9A1	1
GO:0019865	immunoglobulin binding	1/975	23/18367	0.715013513345936	0.831787077083338	LGALS3	1
GO:0030552	cAMP binding	1/975	23/18367	0.715013513345936	0.831787077083338	PDE4B	1
GO:0003777	microtubule motor activity	3/975	69/18367	0.716544204614224	0.832521873867969	DYNC1H1/DYNLRB1/KIF5B	3
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/975	47/18367	0.720414838934733	0.835970101320254	GABRE/ADRB1	2
GO:0003774	cytoskeletal motor activity	5/975	114/18367	0.729983074095002	0.840060833146799	MYH10/DYNC1H1/MYL6/DYNLRB1/KIF5B	5
GO:0001965	G-protein alpha-subunit binding	1/975	24/18367	0.730160799896727	0.840060833146799	NUCB2	1
GO:0008171	O-methyltransferase activity	1/975	24/18367	0.730160799896727	0.840060833146799	LCMT1	1
GO:0010857	calcium-dependent protein kinase activity	1/975	24/18367	0.730160799896727	0.840060833146799	PKN2	1
GO:0016769	transferase activity, transferring nitrogenous groups	1/975	24/18367	0.730160799896727	0.840060833146799	GAPDH	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/975	24/18367	0.730160799896727	0.840060833146799	BMP7	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	2/975	48/18367	0.731197658224968	0.840060833146799	RIMKLB/GCLM	2
GO:0120013	lipid transfer activity	2/975	48/18367	0.731197658224968	0.840060833146799	ABCA1/NPC2	2
GO:0004112	cyclic-nucleotide phosphodiesterase activity	1/975	25/18367	0.744503776514548	0.850074595625736	PDE4B	1
GO:0005160	transforming growth factor beta receptor binding	1/975	25/18367	0.744503776514548	0.850074595625736	TGFBR3	1
GO:0005227	calcium activated cation channel activity	1/975	25/18367	0.744503776514548	0.850074595625736	KCNN4	1
GO:0030247	polysaccharide binding	1/975	25/18367	0.744503776514548	0.850074595625736	AGL	1
GO:0070330	aromatase activity	1/975	25/18367	0.744503776514548	0.850074595625736	CYP19A1	1
GO:0042578	phosphoric ester hydrolase activity	17/975	366/18367	0.749173687144784	0.854353244206983	DUSP6/PLPP3/DUSP1/DLG1/PTPN14/PHPT1/PTPRF/CTDSPL/PTPRA/PDE4B/PTPN12/PDIA3/PTPRE/TNS3/CAMK2G/HMOX1/CDKN3	17
GO:0140359	ABC-type transporter activity	2/975	50/18367	0.751704153142882	0.856184558192262	ATP13A3/ABCA1	2
GO:0020037	heme binding	6/975	139/18367	0.753426510464273	0.857092074557637	CYP2J2/CYP11A1/CYP19A1/HMOX1/STC2/SDHC	6
GO:0038187	pattern recognition receptor activity	1/975	26/18367	0.758085109951377	0.859224983861659	COLEC12	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/975	26/18367	0.758085109951377	0.859224983861659	SLC26A2	1
GO:0099604	ligand-gated calcium channel activity	1/975	26/18367	0.758085109951377	0.859224983861659	MCOLN3	1
GO:0070851	growth factor receptor binding	6/975	141/18367	0.76538768802484	0.866441319206604	APP/IL6ST/EFEMP1/ATXN2/GATA3/ARF4	6
GO:0004683	calmodulin-dependent protein kinase activity	1/975	27/18367	0.770945205791157	0.871666984813934	CAMK2G	1
GO:0050661	NADP binding	2/975	53/18367	0.779928844670075	0.878995485917171	GAPDH/IDH1	2
GO:1901618	organic hydroxy compound transmembrane transporter activity	2/975	53/18367	0.779928844670075	0.878995485917171	SLC5A3/SLC6A4	2
GO:0005179	hormone activity	5/975	122/18367	0.782180826724678	0.878995485917171	FBN1/IGF2/CSH1/COPA/STC2	5
GO:0004629	phospholipase C activity	1/975	28/18367	0.783122328165946	0.878995485917171	PDIA3	1
GO:0017056	structural constituent of nuclear pore	1/975	28/18367	0.783122328165946	0.878995485917171	TPR	1
GO:0051861	glycolipid binding	1/975	28/18367	0.783122328165946	0.878995485917171	PSAP	1
GO:0008374	O-acyltransferase activity	2/975	54/18367	0.788692309809932	0.884175640295395	CROT/PRDX6	2
GO:0030971	receptor tyrosine kinase binding	3/975	78/18367	0.79030811005188	0.884915731448659	EIF3A/PTPN14/PIK3R1	3
GO:0004033	aldo-keto reductase (NADP) activity	1/975	29/18367	0.794652713139947	0.886564352250109	AKR1B1	1
GO:0004181	metallocarboxypeptidase activity	1/975	29/18367	0.794652713139947	0.886564352250109	CPD	1
GO:0033612	receptor serine/threonine kinase binding	1/975	29/18367	0.794652713139947	0.886564352250109	BMP7	1
GO:0004497	monooxygenase activity	4/975	102/18367	0.796929667870174	0.888034744221156	CYP2J2/CYP11A1/CYP19A1/HMOX1	4
GO:0005217	intracellular ligand-gated ion channel activity	1/975	30/18367	0.805570676096024	0.896584670751104	MCOLN3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	2/975	57/18367	0.813160702434422	0.903945750845468	NDUFA13/NDUFA6	2
GO:1990782	protein tyrosine kinase binding	4/975	105/18367	0.814965621366534	0.904828106164012	ITGB1/EIF3A/PTPN14/PIK3R1	4
GO:0043015	gamma-tubulin binding	1/975	31/18367	0.81590871344163	0.904828106164012	PDE4B	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	2/975	58/18367	0.820736445815047	0.908457009029793	SLC27A2/SLC16A12	2
GO:0004519	endonuclease activity	5/975	129/18367	0.821143106434057	0.908457009029793	RPS3/N4BP2/RAD50/DICER1/AGO2	5
GO:0004252	serine-type endopeptidase activity	7/975	174/18367	0.822589561644182	0.908971281721375	CTSC/CTSV/MMP14/PCSK7/MBTPS1/HTRA1/DPP4	7
GO:0048019	receptor antagonist activity	1/975	32/18367	0.825697598934345	0.909150982893226	LRPAP1	1
GO:0050699	WW domain binding	1/975	32/18367	0.825697598934345	0.909150982893226	PRRG4	1
GO:0051721	protein phosphatase 2A binding	1/975	32/18367	0.825697598934345	0.909150982893226	BOD1L1	1
GO:0001540	amyloid-beta binding	3/975	84/18367	0.83004976165885	0.912857576361158	LRP1/LRPAP1/CLSTN1	3
GO:0005319	lipid transporter activity	6/975	154/18367	0.832770388543136	0.912928611293262	SLC2A1/SLC27A2/ABCA1/ATP10D/OSBPL9/NPC2	6
GO:0004623	phospholipase A2 activity	1/975	33/18367	0.834966474911384	0.912928611293262	PRDX6	1
GO:0019239	deaminase activity	1/975	33/18367	0.834966474911384	0.912928611293262	ADAR	1
GO:0051427	hormone receptor binding	1/975	33/18367	0.834966474911384	0.912928611293262	CSH1	1
GO:0050660	flavin adenine dinucleotide binding	3/975	85/18367	0.836005027925269	0.912928611293262	DHCR24/ETFA/CYB5R1	3
GO:0016779	nucleotidyltransferase activity	5/975	132/18367	0.836029656994262	0.912928611293262	POLR2J3/PTGES3/POLR2A/UGP2/NANS	5
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	9/975	222/18367	0.839162962940316	0.915270793501452	CROT/PRDX6/NCOA3/USP22/HGSNAT/NMT1/EP300/HADHA/TAF9	9
GO:0015020	glucuronosyltransferase activity	1/975	34/18367	0.843742938692414	0.91918348379903	CHPF	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/975	62/18367	0.848351494355	0.923118077288754	GABRE/ADRB1	2
GO:0043177	organic acid binding	5/975	135/18367	0.84988689087264	0.923703357920264	NR2F2/GLDC/S100A9/RXRA/SLC19A1	5
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3/975	88/18367	0.852801925293104	0.925784973999313	NDUFA13/NDUFA6/CYB5R1	3
GO:0008081	phosphoric diester hydrolase activity	3/975	89/18367	0.858057632693546	0.928276474700979	PDE4B/PDIA3/HMOX1	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/975	36/18367	0.859921780514837	0.928276474700979	ADAR	1
GO:0034061	DNA polymerase activity	1/975	36/18367	0.859921780514837	0.928276474700979	PTGES3	1
GO:0042605	peptide antigen binding	1/975	36/18367	0.859921780514837	0.928276474700979	DHCR24	1
GO:0016746	acyltransferase activity	10/975	250/18367	0.860109303772614	0.928276474700979	CROT/PRDX6/KMT2C/NCOA3/USP22/HGSNAT/NMT1/EP300/HADHA/TAF9	10
GO:0001664	G protein-coupled receptor binding	12/975	295/18367	0.864199940002232	0.931605523215445	ITGB4/RNF43/WLS/ADRB1/HSPA1A/ZNRF3/GNAQ/GNA12/CALM1/HOMER1/HSPA1B/NPB	12
GO:0008083	growth factor activity	6/975	162/18367	0.865888874889401	0.931872001115933	GRN/IGF2/EFEMP1/CSH1/JAG1/BMP7	6
GO:0030145	manganese ion binding	2/975	65/18367	0.866459819612115	0.931872001115933	EXTL2/GALNT1	2
GO:0019825	oxygen binding	1/975	39/18367	0.881106784770373	0.946525385959821	CYP19A1	1
GO:0005262	calcium channel activity	4/975	119/18367	0.882487923728337	0.946910564742109	ITGAV/ANXA2/MCOLN3/TRPV6	4
GO:0017080	sodium channel regulator activity	1/975	40/18367	0.887431582066798	0.947915363975171	ATP2B4	1
GO:0042287	MHC protein binding	1/975	40/18367	0.887431582066798	0.947915363975171	TUBB4B	1
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	1/975	40/18367	0.887431582066798	0.947915363975171	SERPINB9	1
GO:0004521	endoribonuclease activity	2/975	69/18367	0.887519028689496	0.947915363975171	DICER1/AGO2	2
GO:0004812	aminoacyl-tRNA ligase activity	1/975	41/18367	0.893420244012827	0.95202203217017	IARS2	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	1/975	41/18367	0.893420244012827	0.95202203217017	IARS2	1
GO:0004896	cytokine receptor activity	3/975	97/18367	0.894485861301863	0.952061962718994	CSF3R/IL6ST/PRLR	3
GO:0019842	vitamin binding	5/975	148/18367	0.899146700569035	0.955924046758813	GLDC/MTR/PDXDC1/PYGL/SLC19A1	5
GO:0004180	carboxypeptidase activity	1/975	43/18367	0.904459602254648	0.960469715238308	CPD	1
GO:0005506	iron ion binding	5/975	151/18367	0.908291117659977	0.962556577552731	FTH1/CYP2J2/CYP11A1/TET2/CYP19A1	5
GO:0022839	ion gated channel activity	1/975	44/18367	0.909543202331145	0.962556577552731	KCNN4	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/975	44/18367	0.909543202331145	0.962556577552731	GABRE	1
GO:0004715	non-membrane spanning protein tyrosine kinase activity	1/975	45/18367	0.914356572288419	0.965443769599858	BAZ1B	1
GO:0005245	voltage-gated calcium channel activity	1/975	45/18367	0.914356572288419	0.965443769599858	ITGAV	1
GO:0004620	phospholipase activity	3/975	104/18367	0.919223028954151	0.969476679739799	PRDX6/PDIA3/HMOX1	3
GO:0046873	metal ion transmembrane transporter activity	17/975	430/18367	0.920830712431536	0.970067394438683	ATP2B1/ITGAV/SLC39A10/SLC38A1/ANXA2/SLC38A2/KCNN4/ATP2B4/SLC5A3/SLC9A1/MCOLN3/SLC40A1/SLC13A4/TRPV6/SLC6A4/SLC3A2/SLC13A3	17
GO:0016763	pentosyltransferase activity	1/975	49/18367	0.931183584907196	0.97874687812039	PARP1	1
GO:0032813	tumor necrosis factor receptor superfamily binding	1/975	49/18367	0.931183584907196	0.97874687812039	CFLAR	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	1/975	50/18367	0.934846430453407	0.981482760317295	MAN2A1	1
GO:0008227	G protein-coupled amine receptor activity	1/975	51/18367	0.938314505482501	0.983420505985452	ADRB1	1
GO:0008146	sulfotransferase activity	1/975	52/18367	0.941598156779431	0.983420505985452	TPST2	1
GO:0016597	amino acid binding	1/975	52/18367	0.941598156779431	0.983420505985452	GLDC	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/975	52/18367	0.941598156779431	0.983420505985452	AGL	1
GO:0016874	ligase activity	5/975	165/18367	0.942002147742005	0.983420505985452	ACSS1/SLC27A2/IARS2/RIMKLB/GCLM	5
GO:0008408	3'-5' exonuclease activity	1/975	54/18367	0.94765085884631	0.988203485688832	RAD50	1
GO:0005548	phospholipid transporter activity	1/975	57/18367	0.955575344425438	0.995346196780603	ABCA1	1
GO:0022824	transmitter-gated ion channel activity	1/975	60/18367	0.962301282845368	0.999933435974082	GABRE	1
GO:0022835	transmitter-gated channel activity	1/975	60/18367	0.962301282845368	0.999933435974082	GABRE	1
GO:0016298	lipase activity	3/975	129/18367	0.970344399952459	0.999933435974082	PRDX6/PDIA3/HMOX1	3
GO:0008173	RNA methyltransferase activity	1/975	65/18367	0.971327159513757	0.999933435974082	RNMT	1
GO:0016782	transferase activity, transferring sulphur-containing groups	1/975	68/18367	0.975670051726251	0.999933435974082	TPST2	1
GO:0051536	iron-sulfur cluster binding	1/975	68/18367	0.975670051726251	0.999933435974082	RPS3	1
GO:0051540	metal cluster binding	1/975	68/18367	0.975670051726251	0.999933435974082	RPS3	1
GO:0005126	cytokine receptor binding	8/975	271/18367	0.977965408909296	0.999933435974082	MIF/TGFBR3/IL6ST/PRLR/CSH1/PIK3R1/CFLAR/GATA3	8
GO:0005230	extracellular ligand-gated ion channel activity	1/975	73/18367	0.981497435970515	0.999933435974082	GABRE	1
GO:0030594	neurotransmitter receptor activity	2/975	111/18367	0.983269757698673	0.999933435974082	GABRE/ADRB1	2
GO:0005244	voltage-gated ion channel activity	5/975	201/18367	0.98375505429557	0.999933435974082	ITGAV/CLIC3/CLIC1/VDAC1/VDAC2	5
GO:0022832	voltage-gated channel activity	5/975	201/18367	0.98375505429557	0.999933435974082	ITGAV/CLIC3/CLIC1/VDAC1/VDAC2	5
GO:0140375	immune receptor activity	3/975	144/18367	0.984210806083337	0.999933435974082	CSF3R/IL6ST/PRLR	3
GO:0052689	carboxylic ester hydrolase activity	3/975	147/18367	0.986111240223389	0.999933435974082	PRDX6/PGAP1/IARS2	3
GO:0004540	ribonuclease activity	2/975	116/18367	0.986788147250421	0.999933435974082	DICER1/AGO2	2
GO:0004527	exonuclease activity	1/975	80/18367	0.987390356583705	0.999933435974082	RAD50	1
GO:0022836	gated channel activity	10/975	340/18367	0.987539745204301	0.999933435974082	ITGAV/CLIC3/GABRE/TMC5/KCNN4/TMEM150C/MCOLN3/CLIC1/VDAC1/VDAC2	10
GO:0004518	nuclease activity	5/975	210/18367	0.988391062346273	0.999933435974082	RPS3/N4BP2/RAD50/DICER1/AGO2	5
GO:0030546	signaling receptor activator activity	16/975	495/18367	0.990024883219425	0.999933435974082	FBN1/SEMA6A/APP/MIF/GRN/IGF2/SEMA6D/EFEMP1/CSH1/COPA/LRPAP1/JAG1/LGALS3/BMP7/DPP4/STC2	16
GO:0015267	channel activity	15/975	480/18367	0.992213105165089	0.999933435974082	ITGAV/CLIC3/GJA1/ANXA2/GABRE/TMC5/CLDN4/KCNN4/TMEM150C/MCOLN3/CLIC1/TRPV6/GJA5/VDAC1/VDAC2	15
GO:0022803	passive transmembrane transporter activity	15/975	481/18367	0.992425043030967	0.999933435974082	ITGAV/CLIC3/GJA1/ANXA2/GABRE/TMC5/CLDN4/KCNN4/TMEM150C/MCOLN3/CLIC1/TRPV6/GJA5/VDAC1/VDAC2	15
GO:0005216	ion channel activity	13/975	432/18367	0.992466970726068	0.999933435974082	ITGAV/CLIC3/ANXA2/GABRE/TMC5/CLDN4/KCNN4/TMEM150C/MCOLN3/CLIC1/TRPV6/VDAC1/VDAC2	13
GO:0140098	catalytic activity, acting on RNA	11/975	386/18367	0.993375905102895	0.999933435974082	POLR2J3/DDX5/DDX17/IARS2/DICER1/DDX39B/AGO2/POLR2A/DDX46/RNMT/DDX24	11
GO:0048018	receptor ligand activity	15/975	487/18367	0.993588257262665	0.999933435974082	FBN1/SEMA6A/MIF/GRN/IGF2/SEMA6D/EFEMP1/CSH1/COPA/LRPAP1/JAG1/LGALS3/BMP7/DPP4/STC2	15
GO:0015276	ligand-gated ion channel activity	2/975	143/18367	0.996392584628825	0.999933435974082	GABRE/MCOLN3	2
GO:0022834	ligand-gated channel activity	2/975	143/18367	0.996392584628825	0.999933435974082	GABRE/MCOLN3	2
GO:0008528	G protein-coupled peptide receptor activity	2/975	147/18367	0.997032183422893	0.999933435974082	LGR5/LGR4	2
GO:0001653	peptide receptor activity	2/975	153/18367	0.997788014522698	0.999933435974082	LGR5/LGR4	2
GO:0099094	ligand-gated cation channel activity	1/975	113/18367	0.997935792142568	0.999933435974082	MCOLN3	1
GO:0015079	potassium ion transmembrane transporter activity	2/975	155/18367	0.997995071132531	0.999933435974082	KCNN4/SLC9A1	2
GO:0005267	potassium channel activity	1/975	121/18367	0.998669544681475	0.999933435974082	KCNN4	1
GO:0140101	catalytic activity, acting on a tRNA	1/975	124/18367	0.998871645141056	0.999933435974082	IARS2	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/975	125/18367	0.998931950243697	0.999933435974082	ADAR	1
GO:0022843	voltage-gated cation channel activity	1/975	143/18367	0.999602821668085	0.999933435974082	ITGAV	1
GO:0005125	cytokine activity	3/975	235/18367	0.999743318016161	0.999933435974082	MIF/GRN/BMP7	3
GO:0003823	antigen binding	1/975	171/18367	0.999914917180981	0.999933435974082	DHCR24	1
GO:0005261	cation channel activity	5/975	335/18367	0.999933435974082	0.999933435974082	ITGAV/ANXA2/KCNN4/MCOLN3/TRPV6	5