ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0002181 cytoplasmic translation 60/969 148/18722 2.56401330567164e-38 1.339953353544e-34 RPLP0/RPS3A/RPS13/RPS21/RPL14/RPL19/RPL8/RPL6/RPL18A/RPS10/RPS12/RPS6/RPL23A/RPL24/RPL13/RPS25/RPL26/RPS8/RPLP1/RPL29/RPS26/RPL3/RPS2/RPL10A/RPS16/RPS27A/RPL28/RPL13A/RPL15/RPL21/RPS4X/RPL7A/RPL12/RPL11/RPL10/UBA52/RPS20/PKM/RPL9/EIF3A/RPL22/RPL27/RPL7/RPS3/RPS5/RPL17/RPS11/RPL4/RPL27A/RPL35/RPSA/RPL31/EIF2S2/EIF3H/EIF4G1/RPL36A/EIF3I/EIF3F/EIF4H/EIF4B 60 GO:0008380 RNA splicing 71/969 434/18722 3.79261031258351e-18 9.91009074678072e-15 AHNAK/RPS13/SON/FUS/RBM39/SF1/RPS26/ZC3H13/RBM25/DDX5/SCAF11/SRRM2/PRDX6/DDX17/PNN/SNRPD2/SRSF5/TRA2B/NPM1/PRPF38B/SLC38A2/SRSF7/LUC7L3/ZNF638/HSPA1A/YBX1/MBNL3/HNRNPA1/PRPF4B/PPIG/PIK3R1/SUGP2/SRSF11/CELF1/THOC2/TCERG1/TIA1/SRSF2/SAP18/PRPF40A/ZNF326/LGALS3/MBNL1/DDX39B/RBM5/PAXBP1/CDK12/RBM6/SF3B1/POLR2A/SETX/YTHDC1/SUPT6H/DDX46/PDCD7/THRAP3/QKI/SRSF6/PABPC1/SNRPG/REST/TRA2A/LSM3/SFPQ/IWS1/HNRNPC/HNRNPU/SNU13/SNRPD1/SNRPC/PRMT1 71 GO:0043484 regulation of RNA splicing 37/969 148/18722 5.63594976070024e-16 9.81782448313982e-13 AHNAK/RPS13/SON/FUS/RBM39/SF1/RPS26/RBM25/DDX5/PRDX6/DDX17/SRSF5/TRA2B/NPM1/SLC38A2/SRSF7/HSPA1A/MBNL3/HNRNPA1/PIK3R1/CELF1/TIA1/SRSF2/SAP18/ZNF326/MBNL1/RBM5/CDK12/POLR2A/SETX/YTHDC1/THRAP3/QKI/SRSF6/REST/TRA2A/HNRNPU 37 GO:0050684 regulation of mRNA processing 31/969 137/18722 2.3188982118404e-12 3.02964051376948e-09 SON/RBM39/ZFP36L1/SF1/RBM25/DDX5/PRDX6/DDX17/TRA2B/NPM1/SRSF7/MBNL3/HNRNPA1/CELF1/TIA1/SRSF2/SAP18/MBNL1/RBM5/AHCYL1/YTHDC1/SUPT6H/THRAP3/QKI/SRSF6/SLTM/REST/TRA2A/IWS1/HNRNPU/CCNB1 31 GO:0071826 ribonucleoprotein complex subunit organization 40/969 227/18722 8.31001738940145e-12 8.6856301754024e-09 RPLP0/RPL6/RPL23A/RPL24/SF1/RPL3/RPL13A/RPL11/RPL10/PRKDC/EIF3A/SCAF11/RPS5/SNRPD2/SRSF5/RPSA/EIF2S2/EIF3H/LUC7L3/PTGES3/KIF5B/DICER1/CELF1/EIF3I/ADAR/DDX39B/RBM5/AGO2/SF3B1/SETX/YTHDC1/EIF3F/SRSF6/EIF4H/SNRPG/SNU13/EIF4B/SNRPD1/SNRPC/TAF9 40 GO:0022618 ribonucleoprotein complex assembly 39/969 220/18722 1.25290529471453e-11 1.09128051169636e-08 RPLP0/RPL6/RPL23A/RPL24/SF1/RPL3/RPL13A/RPL11/RPL10/PRKDC/EIF3A/SCAF11/RPS5/SNRPD2/SRSF5/RPSA/EIF2S2/EIF3H/LUC7L3/PTGES3/DICER1/CELF1/EIF3I/ADAR/DDX39B/RBM5/AGO2/SF3B1/SETX/YTHDC1/EIF3F/SRSF6/EIF4H/SNRPG/SNU13/EIF4B/SNRPD1/SNRPC/TAF9 39 GO:0048024 regulation of mRNA splicing, via spliceosome 25/969 101/18722 3.87554570362051e-11 2.89337169244583e-08 SON/RBM39/SF1/RBM25/DDX5/PRDX6/DDX17/TRA2B/NPM1/SRSF7/MBNL3/HNRNPA1/CELF1/TIA1/SRSF2/SAP18/MBNL1/RBM5/YTHDC1/THRAP3/QKI/SRSF6/REST/TRA2A/HNRNPU 25 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 47/969 320/18722 9.54126474073092e-11 5.43218469149873e-08 SON/RBM39/SF1/RBM25/DDX5/SCAF11/SRRM2/PRDX6/DDX17/PNN/SNRPD2/SRSF5/TRA2B/NPM1/SRSF7/LUC7L3/MBNL3/HNRNPA1/PRPF4B/CELF1/TIA1/SRSF2/SAP18/PRPF40A/MBNL1/DDX39B/RBM5/PAXBP1/RBM6/SF3B1/SETX/YTHDC1/DDX46/THRAP3/QKI/SRSF6/PABPC1/SNRPG/REST/TRA2A/LSM3/SFPQ/HNRNPC/HNRNPU/SNU13/SNRPD1/SNRPC 47 GO:0000398 mRNA splicing, via spliceosome 47/969 320/18722 9.54126474073092e-11 5.43218469149873e-08 SON/RBM39/SF1/RBM25/DDX5/SCAF11/SRRM2/PRDX6/DDX17/PNN/SNRPD2/SRSF5/TRA2B/NPM1/SRSF7/LUC7L3/MBNL3/HNRNPA1/PRPF4B/CELF1/TIA1/SRSF2/SAP18/PRPF40A/MBNL1/DDX39B/RBM5/PAXBP1/RBM6/SF3B1/SETX/YTHDC1/DDX46/THRAP3/QKI/SRSF6/PABPC1/SNRPG/REST/TRA2A/LSM3/SFPQ/HNRNPC/HNRNPU/SNU13/SNRPD1/SNRPC 47 GO:1903311 regulation of mRNA metabolic process 44/969 288/18722 1.03945363404109e-10 5.43218469149873e-08 SON/FUS/RBM39/ZFP36L1/SF1/RBM25/DDX5/PRDX6/DDX17/TRA2B/ROCK1/NPM1/PUM1/TNRC6B/SRSF7/YBX1/MBNL3/HNRNPA1/TNRC6A/CELF1/TIA1/SRSF2/SAP18/PUM2/LARP1/MBNL1/RBM5/AGO2/MAPK14/AHCYL1/YTHDC1/SUPT6H/BTG2/THRAP3/QKI/SRSF6/PABPC1/SLTM/REST/TRA2A/IWS1/HNRNPC/HNRNPU/CCNB1 44 GO:0000375 RNA splicing, via transesterification reactions 47/969 324/18722 1.46771917240007e-10 6.97300035905704e-08 SON/RBM39/SF1/RBM25/DDX5/SCAF11/SRRM2/PRDX6/DDX17/PNN/SNRPD2/SRSF5/TRA2B/NPM1/SRSF7/LUC7L3/MBNL3/HNRNPA1/PRPF4B/CELF1/TIA1/SRSF2/SAP18/PRPF40A/MBNL1/DDX39B/RBM5/PAXBP1/RBM6/SF3B1/SETX/YTHDC1/DDX46/THRAP3/QKI/SRSF6/PABPC1/SNRPG/REST/TRA2A/LSM3/SFPQ/HNRNPC/HNRNPU/SNU13/SNRPD1/SNRPC 47 GO:0022613 ribonucleoprotein complex biogenesis 58/969 463/18722 3.95144809810363e-10 1.72085564672413e-07 RPLP0/RPS21/RPL14/RPL6/RPS6/RPL23A/RPL24/RPS25/RPL26/RPS8/SF1/RPL3/RPL10A/RPS16/RPL13A/RPL7A/RPL11/RPL10/PRKDC/EIF3A/RPL27/RPL7/SCAF11/RPS5/DDX17/SNRPD2/SRSF5/RPL35/RPSA/NPM1/EIF2S2/EIF3H/LUC7L3/PTGES3/RAN/DICER1/CELF1/EIF3I/ADAR/DDX39B/RBM5/AGO2/SF3B1/SETX/YTHDC1/XPO1/EIF3F/SRSF6/EIF4H/SNRPG/SNU13/EBNA1BP2/NHP2/EIF4B/SNRPD1/SNRPC/NOP10/TAF9 58 GO:0032970 regulation of actin filament-based process 52/969 396/18722 6.12641966737226e-10 2.46282070628365e-07 AKAP9/LRP1/CAV1/PFN1/IQGAP2/MET/ACTG1/DSP/RHOB/KANK1/IQGAP1/RASA1/S100A10/WASF2/ARPC3/DLG1/ROCK1/AKAP13/DSG2/NRP1/TMSB4X/PHPT1/JAM3/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/DSC2/PDE4B/SLC9A1/PIK3R1/RHOA/ARHGAP18/SVIL/TRIOBP/TAOK1/RHOBTB3/GJA5/PPFIA1/COTL1/ARFGEF1/CDC42/EPS8/ADD3/TMSB10/TACSTD2/ID1/SRI/RHOC/STMN1 52 GO:0048732 gland development 55/969 436/18722 8.76022158245838e-10 3.27006557070911e-07 EGFR/CAV1/RPL19/KRT18/CDH1/DAG1/LAMA5/RPS16/MET/PBX1/WLS/IGF2/PRKDC/LMO4/ANXA1/TGFBR3/ASH1L/SRSF5/ISL1/PSAP/LRP5/NRP1/GPX1/PRLR/LY6E/GLI3/NF1/TBX3/KDM5B/RB1CC1/UPF2/CSNK2B/ARHGAP5/MAN2A1/JARID2/IGSF3/NFIB/DDX39B/BMP7/XBP1/ARID5B/RBPJ/RREB1/ELF3/CFLAR/CITED2/RTN4/TFCP2L1/CDC42/GATA3/KRAS/HMOX1/LBH/HES1/AURKA 55 GO:0060537 muscle tissue development 51/969 403/18722 3.24718721586972e-09 1.13132002600901e-06 LRP2/FOS/CAV1/ITGB1/DSP/IGF2/DDX5/GJA1/NR2F2/PLEC/TGFBR3/DDX17/ISL1/EGR1/DLG1/AKAP13/MYL6/DSG2/GPX1/LY6E/NF1/TBX3/SLC9A1/RHOA/JARID2/SMAD5/SVIL/DMD/DDX39B/YY1/BMP7/MAPK14/EP300/GPC1/GJA5/RBPJ/VGLL4/CFLAR/CITED2/BTG2/HOMER1/CDC42/OBSL1/CDK1/KLF5/CAV2/HNRNPU/CACYBP/CCNB1/PRMT1/HMG20B 51 GO:0014706 striated muscle tissue development 49/969 384/18722 5.03403353703511e-09 1.64424120403409e-06 LRP2/FOS/CAV1/ITGB1/DSP/IGF2/DDX5/GJA1/NR2F2/PLEC/TGFBR3/DDX17/ISL1/EGR1/AKAP13/MYL6/DSG2/GPX1/LY6E/TBX3/SLC9A1/RHOA/JARID2/SMAD5/SVIL/DMD/DDX39B/YY1/BMP7/MAPK14/EP300/GPC1/GJA5/RBPJ/VGLL4/CFLAR/CITED2/BTG2/HOMER1/CDC42/OBSL1/CDK1/KLF5/CAV2/HNRNPU/CACYBP/CCNB1/PRMT1/HMG20B 49 GO:0048608 reproductive structure development 52/969 424/18722 6.74273798214139e-09 2.07279698203946e-06 KRT19/LRP2/KRT8/RPS6/HSPA5/BPTF/ZFP36L1/SF1/ADGRG1/ATRX/ADAMTS1/IGF2/SPINT1/GJA1/ANXA1/NR2F2/LGR4/ASH1L/DLG1/PSAP/EIF2S2/CYP19A1/NIPBL/KDM5A/MAP3K4/BIRC6/HECTD1/DHCR24/SETD2/ITGB8/GLI3/TBX3/KDM5B/EPAS1/NRIP1/JUNB/CTSV/MMP14/BMP7/MAPK14/ZFX/RHOBTB3/ARID5B/RBPJ/IDH1/HTRA1/MME/CITED2/TMF1/GATA3/HES1/STC2 52 GO:0061458 reproductive system development 52/969 427/18722 8.5801017438456e-09 2.42280976740788e-06 KRT19/LRP2/KRT8/RPS6/HSPA5/BPTF/ZFP36L1/SF1/ADGRG1/ATRX/ADAMTS1/IGF2/SPINT1/GJA1/ANXA1/NR2F2/LGR4/ASH1L/DLG1/PSAP/EIF2S2/CYP19A1/NIPBL/KDM5A/MAP3K4/BIRC6/HECTD1/DHCR24/SETD2/ITGB8/GLI3/TBX3/KDM5B/EPAS1/NRIP1/JUNB/CTSV/MMP14/BMP7/MAPK14/ZFX/RHOBTB3/ARID5B/RBPJ/IDH1/HTRA1/MME/CITED2/TMF1/GATA3/HES1/STC2 52 GO:0016032 viral process 51/969 415/18722 8.80853149268078e-09 2.42280976740788e-06 JUN/EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/CFL1/DDX5/EIF3A/DDB1/RPSA/EEA1/NRP1/PPIA/PKN2/HSPA1A/LY6E/RAN/CTSL/TFRC/MPHOSPH8/FUT8/MAN2A1/SLC1A5/HACD3/RSF1/LARP1/ADAR/EP300/EIF2AK4/PCBP2/P4HB/ITGB5/SLC3A2/EIF3F/DPP4/RXRA/CDC42/PABPC1/UVRAG/REST/GALNT1/KPNA6/HSPA1B/BANF1/CDK1/CAV2/DYNLT1/KPNA2/SSB 51 GO:0006913 nucleocytoplasmic transport 41/969 301/18722 1.41674285157841e-08 3.52566578207085e-06 CDH1/PPP1R10/AKAP13/NPM1/PTPN14/PABPN1/RANBP2/TPR/SETD2/RAN/GLI3/NEMF/FERMT1/HNRNPA1/UPF2/PIK3R1/FAM53C/SMG1/THOC2/TXN/TNPO1/UBR5/PPP1R12A/ZC3H11A/TCF7L2/DDX39B/KPNB1/MAPK14/AHCYL1/YTHDC1/SUPT6H/XPO1/NFKBIA/KPNA6/CDK1/IWS1/YWHAE/PTTG1IP/KPNA2/SEC13/SSB 41 GO:0051169 nuclear transport 41/969 301/18722 1.41674285157841e-08 3.52566578207085e-06 CDH1/PPP1R10/AKAP13/NPM1/PTPN14/PABPN1/RANBP2/TPR/SETD2/RAN/GLI3/NEMF/FERMT1/HNRNPA1/UPF2/PIK3R1/FAM53C/SMG1/THOC2/TXN/TNPO1/UBR5/PPP1R12A/ZC3H11A/TCF7L2/DDX39B/KPNB1/MAPK14/AHCYL1/YTHDC1/SUPT6H/XPO1/NFKBIA/KPNA6/CDK1/IWS1/YWHAE/PTTG1IP/KPNA2/SEC13/SSB 41 GO:0031589 cell-substrate adhesion 46/969 363/18722 1.84744714252963e-08 4.38852671220902e-06 LRP1/ITGB4/ITGA6/LAMB1/ITGAV/LAMC1/CCDC80/DAG1/LAMA5/ITGB1/UTRN/ACTG1/FBLN1/KANK1/MACF1/IQGAP1/RASA1/CD63/CDK6/S100A10/BCAM/ROCK1/NRP1/JAM3/NF1/FERMT1/GCNT2/PTPRA/SLC9A1/PIK3R1/RHOA/SORBS1/TRIOBP/JAG1/MMP14/VCL/ACTN4/P4HB/RREB1/PPFIA1/ITGB5/SLK/CDC42/TACSTD2/ID1/VAMP3 46 GO:0001890 placenta development 26/969 144/18722 2.21266805785619e-08 5.02756663928541e-06 KRT19/KRT8/RPS6/BPTF/ZFP36L1/IGF2/SPINT1/GJA1/NR2F2/ASH1L/MAP3K4/BIRC6/HECTD1/SETD2/ITGB8/EPAS1/JUNB/CTSV/BMP7/MAPK14/RBPJ/HTRA1/MME/CITED2/HES1/STC2 26 GO:2001233 regulation of apoptotic signaling pathway 45/969 356/18722 2.84670814254213e-08 6.19870698038548e-06 TPT1/CAV1/ITGA6/ITGAV/RPL26/MIF/RPL11/ENO1/RPS3/HSPB1/CTSC/MAGED1/GSTP1/NRP1/PPIA/GPX1/PARP1/PHIP/BCLAF1/BIRC6/PMAIP1/USP47/HSPA1A/S100A9/RB1CC1/MCL1/TCF7L2/LGALS3/EIF5A/SIAH1/PDIA3/XBP1/P4HB/CFLAR/DDIT3/SIAH2/GCLM/HSPA1B/SFPQ/HMOX1/PTTG1IP/GHITM/NDUFA13/VDAC2/TAF9 45 GO:0007623 circadian rhythm 32/969 210/18722 3.91510827929538e-08 7.90534917389594e-06 JUN/EGFR/JUND/MYCBP2/PRKDC/DDB1/LGR4/ZFHX3/EGR1/MAGED1/ADRB1/KDM5A/CLDN4/HUWE1/GNAQ/USP9X/BHLHE41/NCOR1/NRIP1/KDM2A/SLC6A4/EP300/SETX/NAGLU/THRAP3/SIAH2/NR2F6/CDK1/ID1/SFPQ/HNRNPU/IMPDH2 32 GO:0150115 cell-substrate junction organization 21/969 101/18722 3.94660549277594e-08 7.90534917389594e-06 LRP1/ITGB4/ITGA6/LAMC1/ACTG1/MACF1/IQGAP1/DST/PLEC/S100A10/ROCK1/NRP1/TLN1/PTPRA/SLC9A1/PIK3R1/RHOA/SORBS1/MMP14/VCL/SLK 21 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 16/969 60/18722 4.08427913691524e-08 7.90534917389594e-06 RBM25/DDX5/DDX17/TRA2B/MBNL3/HNRNPA1/CELF1/SRSF2/SAP18/MBNL1/RBM5/YTHDC1/THRAP3/SRSF6/REST/HNRNPU 16 GO:0045185 maintenance of protein location 20/969 93/18722 4.56080263457304e-08 8.0842209626936e-06 FBN1/FBN2/CAV1/HSPA5/GJA1/ANK3/LTBP1/TMSB4X/SKP1/VPS13C/SCIN/VPS13A/TXN/TAF3/NFKBIA/TMSB10/GOPC/HNRNPU/SRI/KDELR2 20 GO:0071559 response to transforming growth factor beta 36/969 256/18722 4.72995925687607e-08 8.0842209626936e-06 PEG10/FBN1/FBN2/JUN/FOS/CAV1/HSPA5/ZFP36L1/GLG1/COL4A2/TGFBR3/ZFHX3/ROCK1/LTBP1/PARP1/ZNF451/HSPA1A/ITGB8/USP9X/FERMT1/GCNT2/FUT8/TRIM33/LATS2/NR3C1/SMAD5/LTBP3/EP300/NREP/ITGB5/CFLAR/HTRA1/CITED2/ID1/CAV2/HPGD 36 GO:0001667 ameboidal-type cell migration 54/969 475/18722 4.74549250789476e-08 8.0842209626936e-06 NRP2/ITGB4/SEMA6A/PFN1/LAMA5/ITGB1/MET/RHOB/KANK1/GRN/MACF1/SEMA6D/GJA1/EPHB4/ANXA1/NR2F2/S100P/PLEC/HSPB1/PLPP3/WASF2/ISL1/ROCK1/MIA3/LRP5/NRP1/TMSB4X/GPX1/PKN2/NF1/FERMT1/ATP2B4/RAB11A/CSNK2B/RHOA/AMOT/GNA12/FOXP1/AGO2/BMP7/AMOTL1/ARID5B/RREB1/RTN4/DPP4/PDCD6/EMC10/TACSTD2/ID1/GATA3/HMOX1/ANXA3/TPBG/RAB25 54 GO:0006403 RNA localization 31/969 201/18722 4.79546210951974e-08 8.0842209626936e-06 ZFP36L1/NPM1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/YBX1/SETD2/RAN/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YY1/YTHDC1/ATXN2/SUPT6H/XPO1/QKI/IWS1/HNRNPU/NHP2/CCT8/NOP10/SEC13/SSB 31 GO:0007015 actin filament organization 51/969 441/18722 6.5045661054108e-08 1.05319717709543e-05 ALDOA/HSP90B1/PFN1/IQGAP2/MET/ACTG1/RHOB/KANK1/CFL1/RASA1/PLEC/S100A10/WASF2/ARPC3/DLG1/ROCK1/NRP1/TMSB4X/PPP1R9A/DIAPH1/FAT1/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/DIAPH2/SLC9A1/PIK3R1/RHOA/ARHGAP18/SORBS1/SVIL/TRIOBP/PAWR/RHOBTB3/PPFIA1/ITGB5/COTL1/ARFGEF1/CDC42/EPS8/ADD3/CALD1/TMSB10/TACSTD2/TPM4/ID1/EZR/RHOC/STMN1 51 GO:0007044 cell-substrate junction assembly 20/969 95/18722 6.65049882207218e-08 1.05319717709543e-05 LRP1/ITGB4/ITGA6/LAMC1/ACTG1/MACF1/IQGAP1/DST/PLEC/S100A10/ROCK1/NRP1/TLN1/PTPRA/SLC9A1/RHOA/SORBS1/MMP14/VCL/SLK 20 GO:0007346 regulation of mitotic cell cycle 52/969 457/18722 8.19013210847433e-08 1.25364226176299e-05 EGFR/RPL26/APP/ZFP36L1/PBX1/IQGAP1/ADAMTS1/IGF2/PRKDC/BRD4/SOX4/ANXA1/DDB1/PPP1R10/DUSP1/DLG1/LRP5/PKN2/PHIP/TPR/BTG1/USP47/CTDSPL/BRD7/RAB11A/EIF4G1/ANAPC11/ANKRD17/USP22/TAOK3/FOXN3/TAOK1/WAC/BMP7/NEK6/CKS1B/BTG2/UBE2C/PSME2/CDC42/OBSL1/XPC/CDK1/YWHAE/CAV2/HES1/HNRNPU/LCMT1/NUSAP1/TIMP2/CCNB1/AURKA 52 GO:0032956 regulation of actin cytoskeleton organization 44/969 357/18722 8.52148942403727e-08 1.25364226176299e-05 LRP1/PFN1/IQGAP2/MET/ACTG1/RHOB/KANK1/IQGAP1/RASA1/S100A10/WASF2/ARPC3/DLG1/ROCK1/AKAP13/NRP1/TMSB4X/PHPT1/JAM3/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/SLC9A1/PIK3R1/RHOA/ARHGAP18/SVIL/TRIOBP/TAOK1/RHOBTB3/PPFIA1/COTL1/ARFGEF1/CDC42/EPS8/ADD3/TMSB10/TACSTD2/ID1/RHOC/STMN1 44 GO:1902903 regulation of supramolecular fiber organization 46/969 382/18722 8.73851354731263e-08 1.25364226176299e-05 AKAP9/APP/PFN1/IQGAP2/CLIP1/MET/ACTG1/KANK1/RPS3/RASA1/S100A10/WASF2/ARPC3/DLG1/ROCK1/AKAP13/NRP1/TMSB4X/GPX1/PPP1R9A/HSPA1A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/SLC9A1/PIK3R1/RHOA/ARHGAP18/CAMSAP2/SVIL/TRIOBP/TAOK1/PPFIA1/COTL1/ARFGEF1/CDC42/EPS8/ADD3/HSPA1B/TMSB10/TACSTD2/ID1/RHOC/STMN1 46 GO:2001242 regulation of intrinsic apoptotic signaling pathway 27/969 164/18722 8.87576802243221e-08 1.25364226176299e-05 TPT1/CAV1/RPL26/MIF/RPL11/ENO1/RPS3/HSPB1/PPIA/GPX1/PARP1/BCLAF1/PMAIP1/USP47/HSPA1A/S100A9/MCL1/EIF5A/SIAH1/XBP1/P4HB/DDIT3/SFPQ/PTTG1IP/NDUFA13/VDAC2/TAF9 27 GO:0042273 ribosomal large subunit biogenesis 17/969 72/18722 1.09365388699838e-07 1.50406189827725e-05 RPLP0/RPL14/RPL6/RPL23A/RPL24/RPL26/RPL3/RPL10A/RPL7A/RPL11/RPL10/RPL7/RPL35/NPM1/SNU13/EBNA1BP2/NHP2 17 GO:0007179 transforming growth factor beta receptor signaling pathway 30/969 198/18722 1.17785574309201e-07 1.5783266957433e-05 PEG10/FBN1/FBN2/JUN/FOS/CAV1/HSPA5/GLG1/TGFBR3/LTBP1/PARP1/ZNF451/HSPA1A/ITGB8/USP9X/FERMT1/GCNT2/FUT8/TRIM33/LATS2/SMAD5/LTBP3/EP300/NREP/ITGB5/HTRA1/CITED2/ID1/CAV2/HPGD 30 GO:0016570 histone modification 52/969 463/18722 1.24614848274092e-07 1.62809299270101e-05 ATRX/IGF2/BRD4/DDB1/ASH1L/KMT2C/ISL1/NCOA3/TET2/RIF1/UFL1/BAZ1B/NIPBL/KDM5A/SKP1/ZNF451/HUWE1/SETD2/KDM5B/MORF4L2/TBL1X/BRD7/RCOR1/RPS6KA5/NSD1/JARID2/JMJD1C/UBR5/USP22/KDM2A/WAC/PAXBP1/MTF2/PHF20L1/EP300/RTF1/PHF14/SUPT6H/SETD5/BAZ2A/PHF20/REST/CDK1/EID1/GATA3/SFPQ/IWS1/CCNB1/UBE2A/PRMT1/TAF9/AURKA 52 GO:0010810 regulation of cell-substrate adhesion 32/969 221/18722 1.32253498804687e-07 1.68574825549585e-05 LRP1/ITGA6/CCDC80/DAG1/UTRN/ACTG1/FBLN1/KANK1/MACF1/IQGAP1/RASA1/CDK6/S100A10/ROCK1/NRP1/NF1/FERMT1/GCNT2/PTPRA/SLC9A1/PIK3R1/RHOA/TRIOBP/JAG1/MMP14/VCL/ACTN4/P4HB/RREB1/SLK/CDC42/TACSTD2 32 GO:0048545 response to steroid hormone 42/969 339/18722 1.44730374838787e-07 1.78550163281726e-05 EGFR/FOS/ATP2B1/CAV1/FOSB/ZFP36L1/DDX5/RPL27/AGL/ANXA1/DDX17/ISL1/DUSP1/GSTP1/UFL1/PARP1/PTGES3/CLDN4/ARID1A/ESRRG/RHOA/NCOR1/NR3C1/UBR5/FOXP1/CTSV/CALM1/ESRRA/BMP7/EP300/IDH1/PDCD7/CFLAR/UBE2L3/RXRA/USP8/TMF1/REST/KRAS/LBH/ANXA3/HNRNPU 42 GO:0043434 response to peptide hormone 48/969 414/18722 1.46912686971186e-07 1.78550163281726e-05 FBN1/ATP2B1/CAV1/JUND/DAG1/ZFP36L1/KANK1/IQGAP1/IGF2/PRKDC/PKM/SLC2A1/GJA1/ANXA1/CYP11A1/TGFBR3/SRSF5/EGR1/ROCK1/GSTP1/LRP5/IGF1R/PARP1/PHIP/DENND4C/VPS13C/BTG1/PTPRA/GAB1/CSH1/SLC9A1/PIK3R1/ZNF106/SORBS1/ESRRA/BMP7/XBP1/AHCYL1/CFLAR/PTPRE/BTG2/SRSF6/VAMP2/HADHA/GGH/CAV2/CACYBP/STC2 48 GO:0061008 hepaticobiliary system development 25/969 150/18722 2.07494726744818e-07 2.44777218983645e-05 EGFR/RPL19/KRT18/RPS16/MET/ANXA1/TGFBR3/SRSF5/NIPBL/GLI3/NF1/RB1CC1/UPF2/CSNK2B/MAN2A1/JARID2/DDX39B/XBP1/ARID5B/CFLAR/CITED2/KRAS/HMOX1/HES1/AURKA 25 GO:0031333 negative regulation of protein-containing complex assembly 24/969 140/18722 2.10772576621968e-07 2.44777218983645e-05 PFN1/HSPA5/RPL13A/KANK1/LMO4/ISL1/TMSB4X/JAM3/KANK4/SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/EP300/ARFGEF1/CDC42/EPS8/ADD3/TMSB10/LCMT1/DNAJC15/VDAC2/STMN1 24 GO:0045445 myoblast differentiation 18/969 84/18722 2.2603044289682e-07 2.56790237951909e-05 ZFP36L1/DDX5/PLEC/DDX17/ISL1/BTG1/IFRD1/MBNL3/TBX3/EPAS1/JAG1/TCF7L2/MBNL1/MAPK14/RBPJ/DDIT3/FLOT2/REST 18 GO:0071560 cellular response to transforming growth factor beta stimulus 34/969 250/18722 2.50456911745074e-07 2.78486770378671e-05 PEG10/FBN1/FBN2/JUN/FOS/CAV1/HSPA5/ZFP36L1/GLG1/COL4A2/TGFBR3/LTBP1/PARP1/ZNF451/HSPA1A/ITGB8/USP9X/FERMT1/GCNT2/FUT8/TRIM33/LATS2/NR3C1/SMAD5/LTBP3/EP300/NREP/ITGB5/CFLAR/HTRA1/CITED2/ID1/CAV2/HPGD 34 GO:0050657 nucleic acid transport 26/969 163/18722 2.91331098360859e-07 3.10713534700785e-05 ZFP36L1/NPM1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/YBX1/SETD2/RAN/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YTHDC1/ATXN2/SUPT6H/XPO1/QKI/IWS1/SEC13/SSB 26 GO:0050658 RNA transport 26/969 163/18722 2.91331098360859e-07 3.10713534700785e-05 ZFP36L1/NPM1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/YBX1/SETD2/RAN/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YTHDC1/ATXN2/SUPT6H/XPO1/QKI/IWS1/SEC13/SSB 26 GO:0000380 alternative mRNA splicing, via spliceosome 17/969 77/18722 3.09850322242695e-07 3.23855556808065e-05 RBM25/DDX5/DDX17/TRA2B/MBNL3/HNRNPA1/CELF1/SRSF2/SAP18/MBNL1/RBM5/YTHDC1/THRAP3/SRSF6/REST/SFPQ/HNRNPU 17 GO:0110053 regulation of actin filament organization 36/969 277/18722 3.48752244197237e-07 3.57368476112698e-05 PFN1/IQGAP2/MET/ACTG1/KANK1/RASA1/S100A10/WASF2/ARPC3/DLG1/ROCK1/NRP1/TMSB4X/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/SLC9A1/PIK3R1/RHOA/ARHGAP18/SVIL/TRIOBP/PPFIA1/COTL1/ARFGEF1/CDC42/EPS8/ADD3/TMSB10/TACSTD2/ID1/RHOC/STMN1 36 GO:0043254 regulation of protein-containing complex assembly 48/969 427/18722 3.70704233521116e-07 3.72557754688722e-05 AKAP9/PFN1/IQGAP2/HSPA5/CLIP1/MET/RPL13A/KANK1/LMO4/RPS3/RASA1/WASF2/ISL1/ARPC3/DLG1/TMSB4X/PARP1/JAM3/PPP1R9A/HSPA1A/KANK4/FERMT1/SCIN/TFRC/RICTOR/SPTBN1/SPTAN1/EIF4G1/RHOA/ABCA1/ARHGAP18/CAMSAP2/SVIL/TRIOBP/LGALS3/EP300/COTL1/ARFGEF1/CDC42/EPS8/ADD3/HSPA1B/TMSB10/LCMT1/DNAJC15/VDAC2/RHOC/STMN1 48 GO:0032271 regulation of protein polymerization 32/969 232/18722 4.07427225970505e-07 3.99127915534039e-05 AKAP9/PFN1/IQGAP2/CLIP1/MET/KANK1/RPS3/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/HSPA1A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/CAMSAP2/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/HSPA1B/TMSB10/VDAC2/STMN1 32 GO:0051222 positive regulation of protein transport 38/969 303/18722 4.14886351662713e-07 3.99127915534039e-05 TCAF1/EGFR/LRP1/CDH1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANK3/ISL1/PPIA/OAZ1/PHPT1/TPR/FRMD4A/HUWE1/RAN/KIF5B/GLI3/KCNN4/EXOC1/PCM1/PIK3R1/EXPH5/UBR5/TCF7L2/NMT1/MAPK14/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/EZR/YWHAE/SRI 38 GO:0051236 establishment of RNA localization 26/969 166/18722 4.20054254771759e-07 3.99127915534039e-05 ZFP36L1/NPM1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/YBX1/SETD2/RAN/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YTHDC1/ATXN2/SUPT6H/XPO1/QKI/IWS1/SEC13/SSB 26 GO:0015931 nucleobase-containing compound transport 31/969 222/18722 4.68702326575363e-07 4.37399706907651e-05 ZFP36L1/GJA1/SLC25A36/NPM1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/YBX1/SETD2/RAN/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YTHDC1/ATXN2/SUPT6H/SLC25A6/XPO1/SLC35B4/QKI/SLC19A1/IWS1/SEC13/SSB 31 GO:0016055 Wnt signaling pathway 49/969 444/18722 4.86667902346195e-07 4.4619762415109e-05 EGFR/LRP1/CAV1/RPS12/APP/TLE4/KANK1/LGR5/RNF43/MACF1/WLS/SOX4/DDB1/LGR4/CTNND1/PLPP3/ISL1/EGR1/LRP5/USP34/USP47/ZNRF3/GNAQ/GLI3/FERMT1/TBL1X/BRD7/RNF213/CSNK2B/RHOA/LATS2/UBR5/TCF7L2/CHD8/MAPK14/WNK1/AMOTL1/RBPJ/RTF1/VGLL4/DDIT3/SIAH2/USP8/CDC42/ATP6AP2/GATA3/CD24/TPBG/CCNE1 49 GO:0001889 liver development 24/969 147/18722 5.34567562945612e-07 4.81663807578236e-05 EGFR/RPL19/KRT18/RPS16/MET/ANXA1/TGFBR3/SRSF5/GLI3/NF1/RB1CC1/UPF2/CSNK2B/MAN2A1/JARID2/DDX39B/XBP1/ARID5B/CFLAR/CITED2/KRAS/HMOX1/HES1/AURKA 24 GO:0198738 cell-cell signaling by wnt 49/969 446/18722 5.56065491381283e-07 4.925420776201e-05 EGFR/LRP1/CAV1/RPS12/APP/TLE4/KANK1/LGR5/RNF43/MACF1/WLS/SOX4/DDB1/LGR4/CTNND1/PLPP3/ISL1/EGR1/LRP5/USP34/USP47/ZNRF3/GNAQ/GLI3/FERMT1/TBL1X/BRD7/RNF213/CSNK2B/RHOA/LATS2/UBR5/TCF7L2/CHD8/MAPK14/WNK1/AMOTL1/RBPJ/RTF1/VGLL4/DDIT3/SIAH2/USP8/CDC42/ATP6AP2/GATA3/CD24/TPBG/CCNE1 49 GO:1904951 positive regulation of establishment of protein localization 39/969 319/18722 5.66254169679794e-07 4.93207381791101e-05 TCAF1/EGFR/LRP1/CDH1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANK3/ISL1/PPIA/OAZ1/PHPT1/TPR/FRMD4A/HUWE1/RAN/KIF5B/GLI3/KCNN4/EXOC1/PCM1/PIK3R1/EXPH5/UBR5/TCF7L2/NMT1/MAPK14/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/EZR/YWHAE/SRI/CCT8 39 GO:0022604 regulation of cell morphogenesis 38/969 309/18722 6.80955254012225e-07 5.83388878273424e-05 ALDOA/DAG1/MYH10/FBLN1/RHOB/KANK1/MACF1/PRKDC/CFL1/ANXA1/RASA1/CUX1/S100A10/DLG1/MYL12B/NRP1/PHIP/CLDN4/FMNL2/DIAPH1/BRWD1/MYL12A/RHOA/ARHGAP18/PLXNB1/PRPF40A/TRIOBP/RHOBTB3/ACTN4/P4HB/RREB1/SPAG9/CDC42/EPS8/OBSL1/TACSTD2/EZR/RHOC 38 GO:0071383 cellular response to steroid hormone stimulus 29/969 204/18722 7.49778397060643e-07 6.31990629522406e-05 EGFR/ATP2B1/ZFP36L1/DDX5/ANXA1/DDX17/ISL1/GSTP1/UFL1/PARP1/PTGES3/ARID1A/ESRRG/RHOA/NCOR1/NR3C1/UBR5/FOXP1/ESRRA/BMP7/EP300/CFLAR/UBE2L3/RXRA/USP8/TMF1/REST/LBH/HNRNPU 29 GO:0045787 positive regulation of cell cycle 38/969 313/18722 9.38949312971402e-07 7.75440103608486e-05 EGFR/APP/PBX1/DYNC1H1/ATRX/ADAMTS1/IGF2/BRD4/ANXA1/PPP1R10/NPM1/LRP5/PKN2/PHIP/TPR/TBX3/RAB11A/EIF4G1/CCPG1/ANAPC11/RHOA/ANKRD17/USP22/SVIL/DDX39B/SLC6A4/CKS1B/CITED2/UBE2C/CDC42/CDK1/SFPQ/HES1/HNRNPU/NUSAP1/RANBP1/CCNB1/AURKA 38 GO:0000910 cytokinesis 26/969 173/18722 9.49639621717243e-07 7.75440103608486e-05 SON/MYH10/RHOB/RASA1/PLEC/ANK3/ROCK1/PKN2/BIRC6/SETD2/SPTBN1/RAB11A/RHOA/PRPF40A/SVIL/CALM1/SNX18/USP8/CDC42/UVRAG/JTB/CALM2/NUSAP1/RHOC/STMN1/AURKA 26 GO:0072001 renal system development 37/969 302/18722 1.043604411761e-06 8.28812687298259e-05 FBN1/LRP2/ADAMTS6/LAMA5/LGR5/PBX1/IQGAP1/ADAMTS1/DLG5/SOX4/ENPEP/LGR4/FRAS1/EGR1/DLG1/MAGED1/NRP1/NIPBL/GLI3/NF1/AHI1/C1GALT1/IRX2/RHOA/SMAD5/TFAP2A/JAG1/AKR1B1/BMP7/ARID5B/CFLAR/MME/TACSTD2/GATA3/CD24/HES1/HPGD 37 GO:0031032 actomyosin structure organization 28/969 196/18722 1.0480858195254e-06 8.28812687298259e-05 KRT19/KRT8/PFN1/ITGB1/MYH10/MET/ACTG1/PLEC/S100A10/WASF2/ROCK1/AKAP13/NRP1/FRMD6/PPP1R9A/SLC9A1/PIK3R1/RHOA/SORBS1/PPFIA1/ITGB5/CFLAR/CDC42/OBSL1/TACSTD2/RHOC/STMN1/CNN3 28 GO:0007517 muscle organ development 39/969 327/18722 1.0625803683311e-06 8.28812687298259e-05 LRP2/FOS/CAV1/DAG1/LAMA5/UTRN/DSP/IGF2/DDX5/NR2F2/PLEC/TGFBR3/DDX17/ZFHX3/ISL1/EGR1/MYL6/GPX1/LY6E/CHD2/RHOA/ZNF609/SVIL/DMD/PAXBP1/MAPK14/EP300/GPC1/XBP1/ARID5B/RBPJ/CFLAR/CITED2/BTG2/HOMER1/KLF5/CAV2/SRI/HMG20B 39 GO:0003279 cardiac septum development 19/969 103/18722 1.21784159976725e-06 9.35947088291713e-05 LRP2/NRP2/ADAMTS6/LMO4/SOX4/TRIP11/TGFBR3/ISL1/NRP1/HECTD1/TBX3/JAG1/BMP7/MDM4/GJA5/RBPJ/CITED2/GATA3/HES1 19 GO:0001701 in utero embryonic development 42/969 367/18722 1.24041818205628e-06 9.39481944844362e-05 KRT19/KRT8/RPL13/BPTF/ZFP36L1/ITGB1/N4BP2L2/IGF2/SPINT1/BTF3/NR2F2/EIF2S2/KIDINS220/BIRC6/HECTD1/YBX1/LY6E/SETD2/GLI3/TBX3/EPAS1/FUT8/AMOT/MAN2A1/JUNB/RBBP6/MBNL1/CHD8/NMT1/BMP7/YTHDC1/RBPJ/RTF1/SUPT6H/ELF3/CITED2/RTN4/GATA3/HES1/CCNB1/UBE2A/PRMT1 42 GO:0019058 viral life cycle 38/969 317/18722 1.28563357873631e-06 9.59817297496564e-05 EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/DDX5/DDB1/RPSA/EEA1/NRP1/PPIA/PKN2/HSPA1A/LY6E/CTSL/TFRC/MPHOSPH8/SLC1A5/HACD3/LARP1/ADAR/EIF2AK4/PCBP2/P4HB/ITGB5/SLC3A2/DPP4/CDC42/PABPC1/UVRAG/KPNA6/HSPA1B/BANF1/CDK1/CAV2/DYNLT1/KPNA2 38 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 41/969 355/18722 1.30973833313468e-06 9.64041201262227e-05 PEG10/FBN1/FBN2/JUN/LRP2/FOS/LRP1/CAV1/HSPA5/CRIM1/GLG1/DDX5/TGFBR3/EGR1/LTBP1/PARP1/ZNF451/HSPA1A/ITGB8/USP9X/FERMT1/GCNT2/SPTBN1/CSNK2B/FUT8/TRIM33/LATS2/SMAD5/LTBP3/BMP7/MAPK14/EP300/NREP/RBPJ/ITGB5/HTRA1/CITED2/ID1/CAV2/HES1/HPGD 41 GO:0001822 kidney development 36/969 293/18722 1.36027962190612e-06 9.87336292233523e-05 FBN1/LRP2/ADAMTS6/LAMA5/PBX1/IQGAP1/ADAMTS1/DLG5/SOX4/ENPEP/LGR4/FRAS1/EGR1/DLG1/MAGED1/NRP1/NIPBL/GLI3/NF1/AHI1/C1GALT1/IRX2/RHOA/SMAD5/TFAP2A/JAG1/AKR1B1/BMP7/ARID5B/CFLAR/MME/TACSTD2/GATA3/CD24/HES1/HPGD 36 GO:0090068 positive regulation of cell cycle process 31/969 236/18722 1.78519161033469e-06 0.000126927207482815 EGFR/APP/PBX1/DYNC1H1/ATRX/ADAMTS1/IGF2/BRD4/ANXA1/PPP1R10/NPM1/LRP5/PKN2/PHIP/TPR/RAB11A/EIF4G1/ANAPC11/RHOA/ANKRD17/SVIL/DDX39B/UBE2C/CDC42/CDK1/SFPQ/HNRNPU/NUSAP1/RANBP1/CCNB1/AURKA 31 GO:0051017 actin filament bundle assembly 24/969 157/18722 1.80950830312345e-06 0.000126927207482815 HSP90B1/PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/SORBS1/PAWR/PPFIA1/ITGB5/CDC42/EPS8/CALD1/TACSTD2/ID1/EZR/RHOC/STMN1 24 GO:0051651 maintenance of location in cell 29/969 213/18722 1.84128024603659e-06 0.000126927207482815 AKAP9/FTH1/CAV1/HSP90B1/HSPA5/GSTO1/GJA1/GAA/ANK3/TMSB4X/SKP1/ARHGAP21/VPS13C/DIAPH1/SCIN/S100A9/MCOLN3/VPS13A/TXN/DMD/CALM1/TAF3/DDIT3/UVRAG/TMSB10/CALM2/HNRNPU/SRI/KDELR2 29 GO:0010639 negative regulation of organelle organization 40/969 347/18722 1.84586065225679e-06 0.000126927207482815 PFN1/MET/KANK1/ATRX/WASF2/DUSP1/NPM1/TMSB4X/GPX1/PARP1/TPR/PPP1R9A/HSPA1A/HUWE1/KANK4/RAD50/SCIN/TFRC/HNRNPA1/SPTBN1/SPTAN1/PIK3R1/CAMSAP2/SVIL/TRIOBP/TAOK1/BMP7/PPFIA1/ARFGEF1/EPS8/ADD3/TMSB10/TACSTD2/HNRNPC/HNRNPU/LCMT1/GHITM/CCNB1/PTTG1/STMN1 40 GO:0048511 rhythmic process 36/969 298/18722 2.02871200553487e-06 0.000137688947284744 JUN/EGFR/JUND/HSPA5/MYCBP2/ADAMTS1/PRKDC/DDX5/DDB1/LGR4/ZFHX3/EGR1/MAGED1/ADRB1/KDM5A/CLDN4/HUWE1/GNAQ/USP9X/KDM5B/BHLHE41/NCOR1/NRIP1/KDM2A/SLC6A4/EP300/SETX/NAGLU/THRAP3/SIAH2/NR2F6/CDK1/ID1/SFPQ/HNRNPU/IMPDH2 36 GO:0051701 biological process involved in interaction with host 28/969 203/18722 2.12995422532829e-06 0.000142706933096995 EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/DDB1/SERPINB9/RPSA/NRP1/PPIA/HSPA1A/LY6E/CTSL/TFRC/THOC2/SLC1A5/DDX39B/P4HB/ITGB5/SLC3A2/DPP4/RXRA/UVRAG/HSPA1B/CDK1/CAV2/DYNLT1 28 GO:0001655 urogenital system development 39/969 338/18722 2.41909385691351e-06 0.000159809002333704 FBN1/LRP2/ADAMTS6/LAMA5/LGR5/PBX1/IQGAP1/ADAMTS1/DLG5/SOX4/ANXA1/ENPEP/LGR4/FRAS1/EGR1/DLG1/MAGED1/PSAP/NRP1/NIPBL/GLI3/NF1/AHI1/C1GALT1/IRX2/RHOA/SMAD5/TFAP2A/JAG1/AKR1B1/BMP7/ARID5B/CFLAR/MME/TACSTD2/GATA3/CD24/HES1/HPGD 39 GO:0097193 intrinsic apoptotic signaling pathway 35/969 288/18722 2.4463681949285e-06 0.000159809002333704 TPT1/CAV1/RPL26/MIF/RPL11/PRKDC/DDX5/ENO1/RPS3/PPP1R15A/HSPB1/PPIA/GPX1/PARP1/BCLAF1/PMAIP1/USP47/HSPA1A/S100A9/PIK3R1/MCL1/EIF5A/SIAH1/EP300/XBP1/P4HB/DDIT3/SFPQ/CD24/HMOX1/PTTG1IP/NDUFA13/VDAC2/TAF9/CASP4 35 GO:0001952 regulation of cell-matrix adhesion 21/969 128/18722 2.49419092403774e-06 0.00016092150332125 LRP1/DAG1/UTRN/ACTG1/MACF1/IQGAP1/RASA1/CDK6/S100A10/ROCK1/NRP1/NF1/FERMT1/PTPRA/SLC9A1/PIK3R1/RHOA/JAG1/MMP14/VCL/SLK 21 GO:0051235 maintenance of location 38/969 326/18722 2.54366634481402e-06 0.000161409372229981 FBN1/FBN2/AKAP9/FTH1/CAV1/HSP90B1/ITGAV/HSPA5/GSTO1/GJA1/PLIN2/GAA/ANK3/LTBP1/TMSB4X/SKP1/ARHGAP21/VPS13C/DIAPH1/SCIN/S100A9/MCOLN3/ABCA1/NRIP1/VPS13A/TXN/DMD/CALM1/TAF3/NFKBIA/DDIT3/UVRAG/TMSB10/GOPC/CALM2/HNRNPU/SRI/KDELR2 38 GO:0006413 translational initiation 20/969 118/18722 2.56352428149415e-06 0.000161409372229981 RPS3A/RPL13A/EIF3A/RPS3/RPS5/PPP1R15A/HSPB1/NPM1/EIF2S2/EIF3H/TPR/EIF4G1/EIF1/EIF3I/LARP1/AGO2/EIF2AK4/EIF3F/EIF4H/EIF4B 20 GO:0061572 actin filament bundle organization 24/969 161/18722 2.85199431470947e-06 0.000174155560484915 HSP90B1/PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/SORBS1/PAWR/PPFIA1/ITGB5/CDC42/EPS8/CALD1/TACSTD2/ID1/EZR/RHOC/STMN1 24 GO:0048863 stem cell differentiation 28/969 206/18722 2.85232102385482e-06 0.000174155560484915 NRP2/KRT18/SEMA6A/LAMA5/N4BP2L2/PRKDC/SEMA6D/ISL1/PUM1/NRP1/UFL1/SETD2/CHD2/MSI2/JARID2/JAG1/LTBP3/MTF2/CDK12/BMP7/RBPJ/CITED2/PDCD6/REST/TACSTD2/LBH/HES1/HNRNPU 28 GO:0044403 biological process involved in symbiotic interaction 35/969 290/18722 2.86593536197909e-06 0.000174155560484915 GAPDH/JUN/EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/CFL1/DDB1/SERPINB9/RPSA/NRP1/PPIA/GPX1/HSPA1A/LY6E/CTSL/TFRC/THOC2/SLC1A5/DDX39B/EP300/EIF2AK4/P4HB/ITGB5/SLC3A2/DPP4/RXRA/UVRAG/REST/HSPA1B/CDK1/CAV2/DYNLT1 35 GO:0030111 regulation of Wnt signaling pathway 38/969 328/18722 2.94688896262705e-06 0.000177016571479183 EGFR/LRP1/CAV1/RPS12/APP/TLE4/KANK1/LGR5/RNF43/MACF1/WLS/SOX4/LGR4/CTNND1/PLPP3/ISL1/EGR1/USP34/USP47/ZNRF3/GNAQ/GLI3/FERMT1/TBL1X/RNF213/LATS2/UBR5/TCF7L2/CHD8/MAPK14/WNK1/RBPJ/VGLL4/DDIT3/SIAH2/USP8/ATP6AP2/TPBG 38 GO:0051028 mRNA transport 21/969 130/18722 3.22055698041769e-06 0.000191257167950714 ZFP36L1/NCBP3/PABPN1/SRSF7/RANBP2/TPR/SETD2/IGF2BP3/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/EIF5A/YTHDC1/SUPT6H/XPO1/QKI/IWS1/SEC13 21 GO:0032507 maintenance of protein location in cell 14/969 64/18722 3.8179701439095e-06 0.000224187774967091 CAV1/HSPA5/GJA1/ANK3/TMSB4X/SKP1/VPS13C/SCIN/VPS13A/TXN/TAF3/TMSB10/HNRNPU/KDELR2 14 GO:0001892 embryonic placenta development 16/969 82/18722 3.90134859349981e-06 0.000226324710610794 KRT19/KRT8/BPTF/ZFP36L1/IGF2/SPINT1/NR2F2/BIRC6/HECTD1/SETD2/EPAS1/JUNB/BMP7/RBPJ/CITED2/HES1 16 GO:0007160 cell-matrix adhesion 30/969 233/18722 3.94097754794915e-06 0.000226324710610794 LRP1/ITGB4/ITGAV/DAG1/ITGB1/UTRN/ACTG1/MACF1/IQGAP1/RASA1/CD63/CDK6/S100A10/BCAM/ROCK1/NRP1/JAM3/NF1/FERMT1/PTPRA/SLC9A1/PIK3R1/RHOA/SORBS1/JAG1/MMP14/VCL/PPFIA1/ITGB5/SLK 30 GO:0031099 regeneration 27/969 198/18722 4.0129256498186e-06 0.000227951624412522 EGFR/LRP1/RPL19/DAG1/RPS16/GRN/ANXA1/TGFBR3/SRSF5/ISL1/GSTP1/GPX1/PTPRF/JAM3/MTR/GLI3/UPF2/CSNK2B/PTPN12/NREP/CFLAR/CDK1/KLF5/HMOX1/ANXA3/CCNB1/AURKA 27 GO:0031122 cytoplasmic microtubule organization 13/969 56/18722 4.18248854644615e-06 0.0002350288725132 CLIP1/DYNC1H1/DST/DLG1/HOOK2/PCM1/RAB11A/RHOA/CAMSAP2/KPNB1/HOOK3/SLK/EZR 13 GO:0051168 nuclear export 23/969 154/18722 4.42043155454621e-06 0.000245757184085729 AKAP13/NPM1/PTPN14/PABPN1/TPR/SETD2/RAN/NEMF/HNRNPA1/UPF2/SMG1/THOC2/TXN/ZC3H11A/TCF7L2/DDX39B/AHCYL1/YTHDC1/SUPT6H/XPO1/IWS1/YWHAE/SSB 23 GO:0051258 protein polymerization 35/969 296/18722 4.55672744384439e-06 0.000250667974963482 AKAP9/PFN1/IQGAP2/CLIP1/MET/KANK1/RPS3/RASA1/GPX4/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/HSPA1A/DIAPH1/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/CAMSAP2/SVIL/TRIOBP/COTL1/ARFGEF1/UBE2C/EPS8/ADD3/HSPA1B/TMSB10/VDAC2/STMN1 35 GO:0046718 viral entry into host cell 22/969 144/18722 4.86572715675642e-06 0.000263497449984149 EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/RPSA/NRP1/HSPA1A/LY6E/CTSL/TFRC/SLC1A5/P4HB/ITGB5/SLC3A2/DPP4/UVRAG/HSPA1B/CDK1/CAV2/DYNLT1 22 GO:0060538 skeletal muscle organ development 24/969 166/18722 4.916568900184e-06 0.000263497449984149 FOS/CAV1/DAG1/IGF2/DDX5/NR2F2/PLEC/DDX17/EGR1/MYL6/GPX1/RHOA/SVIL/DMD/MAPK14/EP300/GPC1/CFLAR/CITED2/BTG2/HOMER1/KLF5/CAV2/HMG20B 24 GO:0007519 skeletal muscle tissue development 23/969 155/18722 4.94120744325423e-06 0.000263497449984149 FOS/CAV1/IGF2/DDX5/NR2F2/PLEC/DDX17/EGR1/MYL6/GPX1/RHOA/SVIL/DMD/MAPK14/EP300/GPC1/CFLAR/CITED2/BTG2/HOMER1/KLF5/CAV2/HMG20B 23 GO:2001234 negative regulation of apoptotic signaling pathway 29/969 224/18722 5.09546524688645e-06 0.000268978801820491 TPT1/ITGA6/ITGAV/MIF/ENO1/HSPB1/GSTP1/NRP1/PPIA/GPX1/PHIP/BIRC6/USP47/HSPA1A/RB1CC1/MCL1/TCF7L2/LGALS3/XBP1/CFLAR/SIAH2/GCLM/HSPA1B/HMOX1/PTTG1IP/GHITM/NDUFA13/VDAC2/TAF9 29 GO:0031960 response to corticosteroid 24/969 167/18722 5.46549904601741e-06 0.00028562698014487 EGFR/FOS/ATP2B1/FOSB/ZFP36L1/RPL27/AGL/ANXA1/ISL1/DUSP1/GSTP1/PARP1/RHOA/NR3C1/CTSV/CALM1/PDCD7/CFLAR/UBE2L3/USP8/REST/KRAS/ANXA3/HNRNPU 24 GO:0062197 cellular response to chemical stress 38/969 337/18722 5.60440742814815e-06 0.000288020043066615 JUN/EGFR/FOS/CAV1/ZFP36L1/MET/RHOB/SLC2A1/RPS3/ANXA1/PLEC/PRDX1/HSPB1/DHRS2/PPIA/GPX1/PARP1/HSPA1A/EPAS1/FUT8/MCL1/TXN/SOD3/AKR1B1/PAWR/EFHD1/BMP7/SETX/P4HB/CHD6/DDIT3/NFE2L1/REST/HSPA1B/CDK1/SFPQ/HMOX1/SERPINB6 38 GO:0051098 regulation of binding 40/969 363/18722 5.62151633999133e-06 0.000288020043066615 JUN/LRP1/CAV1/APP/C4orf3/MET/RPL11/TGFBR3/S100A10/ISL1/ROCK1/ANXA2/NRP1/TMSB4X/PARP1/PTPRF/RAN/CSNK2B/EIF4G1/CCPG1/NSD1/TXN/RSF1/LRPAP1/TCF7L2/CALM1/EP300/NFKBIA/DDIT3/CDC42/SPPL3/EDF1/ID1/GATA3/HMOX1/CALM2/HES1/SRI/STMN1/AURKA 40 GO:1990830 cellular response to leukemia inhibitory factor 17/969 94/18722 5.80270627346965e-06 0.000294416922185946 NRP2/TLE4/RPS16/RIF1/SRSF7/KDM5B/TFRC/JARID2/MTF2/ARID5B/RNMT/B3GNT2/EPS8/GCLM/KLF5/HNRNPU/CACYBP 17 GO:1903829 positive regulation of cellular protein localization 33/969 276/18722 6.68371217131594e-06 0.000331869449126658 TCAF1/EGFR/LRP1/CDH1/ITGB1/IQGAP1/ANK3/DLG1/NPM1/PARP1/TPR/HUWE1/RAN/KIF5B/GLI3/TFRC/ATP2B4/SLC5A3/SPTBN1/RAB11A/PIK3R1/UBR5/SORBS1/LGALS3/NMT1/MAPK14/RTN4/TM9SF4/NPEPPS/UBE2L3/CDK1/EZR/CCT8 33 GO:0071426 ribonucleoprotein complex export from nucleus 15/969 76/18722 6.71545980259111e-06 0.000331869449126658 NPM1/PABPN1/TPR/SETD2/RAN/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/XPO1/IWS1/SSB 15 GO:1990823 response to leukemia inhibitory factor 17/969 95/18722 6.73137420731454e-06 0.000331869449126658 NRP2/TLE4/RPS16/RIF1/SRSF7/KDM5B/TFRC/JARID2/MTF2/ARID5B/RNMT/B3GNT2/EPS8/GCLM/KLF5/HNRNPU/CACYBP 17 GO:1902850 microtubule cytoskeleton organization involved in mitosis 22/969 147/18722 6.85298422884086e-06 0.000334707435326377 ITGB1/DYNC1H1/GJA1/CLTC/TACC2/TPR/HSPA1A/SETD2/RAN/RAB11A/RHOA/KPNB1/NEK6/STAG1/HSPA1B/HNRNPU/DYNLT1/NUSAP1/CDC20/CCNB1/STMN1/AURKA 22 GO:0140694 non-membrane-bounded organelle assembly 40/969 367/18722 7.32381843510169e-06 0.000353731297754512 RPLP0/KRT19/KRT8/RPL6/PRRC2C/RPL23A/RPL24/ITGB1/RPL3/ACTG1/DYNC1H1/RPL11/RPL10/PRKDC/RPS3/PLEC/RPS5/AKAP13/RPSA/NPM1/TPR/HSPA1A/CEP152/RAB11A/RHOA/NCOR1/PUM2/KPNB1/NEK6/ATXN2/CFLAR/STAG1/OBSL1/HSPA1B/LSM3/EZR/HNRNPU/CENPN/CDC20/AURKA 40 GO:0010649 regulation of cell communication by electrical coupling 7/969 16/18722 7.37786288848868e-06 0.000353731297754512 CAV1/GJA1/ANK3/CALM1/GJA5/CALM2/SRI 7 GO:0051384 response to glucocorticoid 22/969 148/18722 7.66336628285417e-06 0.000357976539666048 EGFR/FOS/ATP2B1/FOSB/ZFP36L1/AGL/ANXA1/ISL1/DUSP1/GSTP1/RHOA/NR3C1/CTSV/CALM1/PDCD7/CFLAR/UBE2L3/USP8/REST/KRAS/ANXA3/HNRNPU 22 GO:0060828 regulation of canonical Wnt signaling pathway 31/969 253/18722 7.66859223348966e-06 0.000357976539666048 EGFR/CAV1/RPS12/TLE4/KANK1/LGR5/WLS/SOX4/LGR4/CTNND1/ISL1/EGR1/USP34/USP47/ZNRF3/GNAQ/GLI3/FERMT1/TBL1X/LATS2/UBR5/TCF7L2/CHD8/MAPK14/WNK1/RBPJ/DDIT3/SIAH2/USP8/ATP6AP2/TPBG 31 GO:0030038 contractile actin filament bundle assembly 18/969 106/18722 7.82367995755999e-06 0.000357976539666048 PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/SORBS1/PPFIA1/ITGB5/CDC42/TACSTD2/RHOC/STMN1 18 GO:0043149 stress fiber assembly 18/969 106/18722 7.82367995755999e-06 0.000357976539666048 PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/SORBS1/PPFIA1/ITGB5/CDC42/TACSTD2/RHOC/STMN1 18 GO:0046822 regulation of nucleocytoplasmic transport 18/969 106/18722 7.82367995755999e-06 0.000357976539666048 CDH1/PTPN14/TPR/SETD2/RAN/GLI3/FERMT1/PIK3R1/TXN/UBR5/PPP1R12A/TCF7L2/MAPK14/SUPT6H/XPO1/CDK1/IWS1/YWHAE 18 GO:0001649 osteoblast differentiation 29/969 229/18722 7.87896067349113e-06 0.000357976539666048 RRBP1/FBN2/JUND/CRIM1/IGF2/DDX5/LGR4/CDK6/IL6ST/LRP5/CLTC/UFL1/SUCO/GLI3/NF1/SMOC1/JUNB/SMAD5/CLIC1/JAG1/CCDC47/ADAR/ESRRA/BMP7/MAPK14/REST/TPM4/HNRNPC/HNRNPU 29 GO:0071166 ribonucleoprotein complex localization 15/969 77/18722 7.94590099526628e-06 0.000357976539666048 NPM1/PABPN1/TPR/SETD2/RAN/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/XPO1/IWS1/SSB 15 GO:0042060 wound healing 44/969 422/18722 8.16052359046298e-06 0.00036450338704068 F5/EGFR/CAV1/DAG1/ITGB1/ACTG1/DSP/FBLN1/KANK1/MACF1/LMAN1/GJA1/DST/ANXA1/PLEC/HSPB1/IL6ST/PLPP3/ANXA2/MIA3/PPIA/GPX1/CLDN4/GNAQ/TLN1/GLI3/NF1/FERMT1/SYT7/MYL12A/RHOA/JMJD1C/GNA12/CLIC1/VCL/MAPK14/XBP1/RREB1/CFLAR/ARFGEF1/MYOF/SRSF6/HMOX1/RHOC 44 GO:0010631 epithelial cell migration 39/969 357/18722 8.99673715856068e-06 0.00039514135534508 NRP2/PFN1/ITGB1/MET/RHOB/KANK1/GRN/MACF1/EPHB4/ANXA1/NR2F2/S100P/HSPB1/PLPP3/ROCK1/MIA3/NRP1/TMSB4X/GPX1/PKN2/NF1/FERMT1/ATP2B4/RAB11A/CSNK2B/RHOA/AMOT/FOXP1/RREB1/RTN4/DPP4/PDCD6/EMC10/TACSTD2/ID1/GATA3/HMOX1/ANXA3/RAB25 39 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 17/969 97/18722 8.99766959166945e-06 0.00039514135534508 ITGA6/ITGAV/GSTP1/NRP1/GPX1/PHIP/BIRC6/HSPA1A/RB1CC1/MCL1/TCF7L2/LGALS3/CFLAR/SIAH2/GCLM/HSPA1B/HMOX1 17 GO:0051101 regulation of DNA binding 19/969 118/18722 9.81622512743376e-06 0.00042749660429974 JUN/ISL1/TMSB4X/PARP1/CSNK2B/NSD1/TXN/RSF1/CALM1/EP300/NFKBIA/DDIT3/EDF1/ID1/GATA3/HMOX1/CALM2/HES1/SRI 19 GO:0001666 response to hypoxia 35/969 307/18722 1.02288371700948e-05 0.000441784322734837 MALAT1/LDHA/CAV1/HSP90B1/ZFP36L1/SLC2A1/ENO1/TGFBR3/EGR1/PMAIP1/HP1BP3/NF1/EPAS1/SLC9A1/RHOA/SOD3/MMP14/DNMT3A/BMP7/SLC6A4/EP300/MDM4/P4HB/RBPJ/CFLAR/CITED2/TM9SF4/NPEPPS/DPP4/REST/CD24/HMOX1/STC2/PGK1/CCNB1 35 GO:0051494 negative regulation of cytoskeleton organization 23/969 162/18722 1.04536908725706e-05 0.00044779498770536 PFN1/MET/KANK1/WASF2/NPM1/TMSB4X/PPP1R9A/KANK4/SCIN/SPTBN1/SPTAN1/PIK3R1/CAMSAP2/SVIL/TRIOBP/TAOK1/PPFIA1/ARFGEF1/EPS8/ADD3/TMSB10/TACSTD2/STMN1 23 GO:0044409 entry into host 22/969 151/18722 1.06422241487621e-05 0.000452164743101063 EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/RPSA/NRP1/HSPA1A/LY6E/CTSL/TFRC/SLC1A5/P4HB/ITGB5/SLC3A2/DPP4/UVRAG/HSPA1B/CDK1/CAV2/DYNLT1 22 GO:0090132 epithelium migration 39/969 360/18722 1.09421857959271e-05 0.000457188038431356 NRP2/PFN1/ITGB1/MET/RHOB/KANK1/GRN/MACF1/EPHB4/ANXA1/NR2F2/S100P/HSPB1/PLPP3/ROCK1/MIA3/NRP1/TMSB4X/GPX1/PKN2/NF1/FERMT1/ATP2B4/RAB11A/CSNK2B/RHOA/AMOT/FOXP1/RREB1/RTN4/DPP4/PDCD6/EMC10/TACSTD2/ID1/GATA3/HMOX1/ANXA3/RAB25 39 GO:0000245 spliceosomal complex assembly 15/969 79/18722 1.10229033376102e-05 0.000457188038431356 SF1/SCAF11/SNRPD2/SRSF5/LUC7L3/CELF1/DDX39B/RBM5/SF3B1/SETX/YTHDC1/SRSF6/SNRPG/SNRPD1/SNRPC 15 GO:0032272 negative regulation of protein polymerization 15/969 79/18722 1.10229033376102e-05 0.000457188038431356 PFN1/KANK1/TMSB4X/KANK4/SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/ARFGEF1/EPS8/ADD3/TMSB10/VDAC2/STMN1 15 GO:0031056 regulation of histone modification 22/969 152/18722 1.18465487752998e-05 0.000487480818108006 ATRX/IGF2/BRD4/ISL1/RIF1/NIPBL/KDM5A/ZNF451/BRD7/RPS6KA5/NSD1/JARID2/UBR5/PAXBP1/MTF2/RTF1/SUPT6H/SETD5/EID1/GATA3/IWS1/CCNB1 22 GO:0052126 movement in host environment 24/969 175/18722 1.23109941916055e-05 0.000502634809729143 EGFR/CAV1/CD46/ITGAV/DAG1/ITGB1/DDB1/RPSA/NRP1/PPIA/HSPA1A/LY6E/CTSL/TFRC/SLC1A5/P4HB/ITGB5/SLC3A2/DPP4/UVRAG/HSPA1B/CDK1/CAV2/DYNLT1 24 GO:0033120 positive regulation of RNA splicing 10/969 37/18722 1.27616378451412e-05 0.000516971879858544 PRDX6/SRSF5/TRA2B/SLC38A2/HSPA1A/PIK3R1/POLR2A/SETX/THRAP3/TRA2A 10 GO:0043620 regulation of DNA-templated transcription in response to stress 12/969 53/18722 1.28599970114066e-05 0.000516971879858544 JUN/HSPA5/EGR1/BCLAF1/HSPA1A/EPAS1/DNAJB1/RBPJ/CHD6/CITED2/DDIT3/HMOX1 12 GO:0031647 regulation of protein stability 34/969 298/18722 1.34096244350973e-05 0.00053428125003329 GAPDH/AAK1/PFN1/GRN/RPL11/PRKDC/SOX4/CTNND1/PLPP3/NPM1/TRIM44/PTGES3/USP47/HSPA1A/GNAQ/USP9X/TBL1X/SEL1L/PIK3R1/USP27X/SIAH1/EP300/MDM4/B4GALT5/RTN4/MYLIP/FLOT2/USP8/HSPA1B/TRIM24/KRAS/CCT8/TAF9/AURKA 34 GO:0110020 regulation of actomyosin structure organization 17/969 100/18722 1.36834537891079e-05 0.00053428125003329 PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/AKAP13/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/PPFIA1/CDC42/TACSTD2/RHOC/STMN1 17 GO:0000281 mitotic cytokinesis 14/969 71/18722 1.36995192316228e-05 0.00053428125003329 SON/MYH10/RHOB/RASA1/ANK3/ROCK1/SPTBN1/RHOA/SNX18/USP8/JTB/NUSAP1/RHOC/STMN1 14 GO:0150116 regulation of cell-substrate junction organization 14/969 71/18722 1.36995192316228e-05 0.00053428125003329 LRP1/ACTG1/MACF1/IQGAP1/S100A10/ROCK1/NRP1/PTPRA/SLC9A1/PIK3R1/RHOA/MMP14/VCL/SLK 14 GO:0048738 cardiac muscle tissue development 29/969 236/18722 1.41287248435299e-05 0.000546938637276202 LRP2/ITGB1/DSP/GJA1/PLEC/TGFBR3/ISL1/AKAP13/DSG2/LY6E/TBX3/SLC9A1/JARID2/SMAD5/DDX39B/YY1/BMP7/MAPK14/GJA5/RBPJ/VGLL4/CITED2/CDC42/OBSL1/CDK1/HNRNPU/CACYBP/CCNB1/PRMT1 29 GO:0042176 regulation of protein catabolic process 41/969 391/18722 1.43967376576747e-05 0.000553215816169175 EEF1A1/EGFR/LRP2/LRP1/CAV1/CDH1/MYCBP2/RPL11/GJA1/DDB1/CTSC/ROCK1/ANXA2/EIF3H/GPX1/UFL1/OAZ1/HECTD1/HSPA1A/HUWE1/DDA1/GNA12/WAC/PSMD1/MDM4/VGLL4/XPO1/TMEM259/MYLIP/PSME2/USP8/TMF1/HSPA1B/EZR/PTTG1IP/NDUFA13/CDC20/PSMC1/TIMP2/TAF9/AURKA 41 GO:0060562 epithelial tube morphogenesis 36/969 325/18722 1.45537734322445e-05 0.000555168028882552 LRP2/PFN1/DAG1/LAMA5/MET/RHOB/LGR5/PBX1/DLG5/SPINT1/LMO4/SOX4/LGR4/DLG1/MAGED1/LRP5/NRP1/BRD2/HECTD1/SETD2/GLI3/TBX3/KDM5B/CSNK2B/AHI1/IRX2/RHOA/FOXP1/MMP14/BMP7/RBPJ/CITED2/TACSTD2/GATA3/KRAS/HES1 36 GO:0090130 tissue migration 39/969 365/18722 1.50627964557244e-05 0.000570421552736347 NRP2/PFN1/ITGB1/MET/RHOB/KANK1/GRN/MACF1/EPHB4/ANXA1/NR2F2/S100P/HSPB1/PLPP3/ROCK1/MIA3/NRP1/TMSB4X/GPX1/PKN2/NF1/FERMT1/ATP2B4/RAB11A/CSNK2B/RHOA/AMOT/FOXP1/RREB1/RTN4/DPP4/PDCD6/EMC10/TACSTD2/ID1/GATA3/HMOX1/ANXA3/RAB25 39 GO:0140014 mitotic nuclear division 33/969 287/18722 1.52259088637922e-05 0.00057245035771351 RPL24/ATRX/IGF2/DUSP1/LRP5/NIPBL/PHIP/TPR/HSPA1A/RAN/RAB11A/ANAPC11/RHOA/PDS5A/EML4/KPNB1/BMP7/NEK6/UBE2C/STAG1/CDC42/EPS8/OBSL1/HSPA1B/CAV2/HNRNPU/LCMT1/NUSAP1/CDC20/RANBP1/CCNB1/PTTG1/AURKA 33 GO:0051492 regulation of stress fiber assembly 16/969 91/18722 1.5725117001009e-05 0.000586996153194807 PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/PPFIA1/CDC42/TACSTD2/RHOC/STMN1 16 GO:0006091 generation of precursor metabolites and energy 48/969 490/18722 1.70776810996413e-05 0.000631100687078147 GAPDH/ALDOA/LDHA/APP/TPI1/CROT/IGF2/PKM/ENO1/AGL/PLEC/ACSS1/IL6ST/GAA/DHRS2/GLDC/COX6A1/CYP19A1/UQCRH/PTGES3/PHKB/COX8C/RB1CC1/RHOA/NCOR1/ASPH/SORBS1/COX5A/AKR1B1/EP300/IDH1/UGP2/PYGL/UQCRQ/COX7B/CDK1/ETFA/TALDO1/PGAM1/DNAJC15/GHITM/NDUFA13/MDH2/STOML2/NDUFA6/PGK1/CCNB1/SDHC 48 GO:0032388 positive regulation of intracellular transport 26/969 202/18722 1.71481625650779e-05 0.000631100687078147 TCAF1/CDH1/DYNC1H1/ANK3/ANXA2/OAZ1/TPR/PGAP1/HUWE1/RAN/KIF5B/GLI3/PCM1/PIK3R1/UBR5/TCF7L2/NMT1/MAPK14/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/EZR/YWHAE 26 GO:0050821 protein stabilization 25/969 191/18722 1.85345715136286e-05 0.000677354340770792 GAPDH/AAK1/PFN1/GRN/RPL11/SOX4/CTNND1/PLPP3/NPM1/TRIM44/PTGES3/HSPA1A/GNAQ/USP9X/TBL1X/SEL1L/PIK3R1/USP27X/EP300/MDM4/RTN4/FLOT2/HSPA1B/CCT8/TAF9 25 GO:0034504 protein localization to nucleus 33/969 290/18722 1.8876797812264e-05 0.000685070453936749 CDH1/RPL11/PPP1R10/MAGED1/NPM1/PARP1/RANBP2/SKP1/TPR/RAN/GLI3/FERMT1/TFRC/PIK3R1/LATS2/FAM53C/TXN/TNPO1/UBR5/KPNB1/BMP7/MAPK14/TAF3/XPO1/NFKBIA/KPNA6/CDK1/YWHAE/HNRNPU/PTTG1IP/CCT8/KPNA2/SEC13 33 GO:0060070 canonical Wnt signaling pathway 34/969 303/18722 1.90511870203843e-05 0.00068663105771399 EGFR/CAV1/RPS12/TLE4/KANK1/LGR5/WLS/SOX4/LGR4/CTNND1/PLPP3/ISL1/EGR1/LRP5/USP34/USP47/ZNRF3/GNAQ/GLI3/FERMT1/TBL1X/LATS2/UBR5/TCF7L2/CHD8/MAPK14/WNK1/RBPJ/DDIT3/SIAH2/USP8/ATP6AP2/GATA3/TPBG 34 GO:0030837 negative regulation of actin filament polymerization 13/969 64/18722 1.97953158114973e-05 0.000708563838567705 PFN1/KANK1/TMSB4X/KANK4/SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/ARFGEF1/EPS8/ADD3/TMSB10 13 GO:0044772 mitotic cell cycle phase transition 43/969 424/18722 2.0338151964759e-05 0.000723042055563472 EGFR/RPS6/RPL24/RPL26/APP/ZFP36L1/ITGB1/PBX1/ADAMTS1/PRKDC/BRD4/SOX4/ANXA1/DDB1/CDK6/DUSP1/DLG1/TPR/USP47/CTDSPL/BRD7/RAB11A/EIF4G1/ANAPC11/LATS2/ANKRD17/TAOK3/FOXN3/TAOK1/CALM1/WAC/NEK6/UBE2C/PSME2/EPS8/XPC/CDK1/CALM2/LCMT1/CDKN3/CCNB1/CCNE1/AURKA 43 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 11/969 47/18722 2.10858204599548e-05 0.000744557417052187 JUN/HSPA5/EGR1/HSPA1A/EPAS1/DNAJB1/RBPJ/CHD6/CITED2/DDIT3/HMOX1 11 GO:0033157 regulation of intracellular protein transport 28/969 229/18722 2.16606418641377e-05 0.000759721573033448 TCAF1/CDH1/LMAN1/ANK3/PTPN14/GCC2/OAZ1/TPR/HUWE1/RAN/KIF5B/GLI3/FERMT1/PCM1/PIK3R1/TXN/UBR5/TCF7L2/NMT1/MAPK14/XPO1/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/YWHAE 28 GO:0007565 female pregnancy 25/969 193/18722 2.21821308252303e-05 0.000772825437951025 FOS/ITGB4/FOSB/RPL29/FBLN1/SLC2A1/GJA1/NR2F2/ASH1L/SLC38A1/SLC38A2/PRLR/CLDN4/JUNB/CTSV/AKR1B1/AGO2/CITED2/MAGED2/KPNA6/KRAS/SLC19A1/STC2/HPGD/UBE2A 25 GO:1903076 regulation of protein localization to plasma membrane 17/969 104/18722 2.32687152331218e-05 0.000801874579225714 EGFR/LRP1/ITGB1/DLG1/CLTC/HECTD1/KIF5B/ATP2B4/SPTBN1/RAB11A/PIK3R1/SORBS1/MMP14/LGALS3/PPFIA1/GOPC/EZR 17 GO:0071385 cellular response to glucocorticoid stimulus 12/969 56/18722 2.33227967934e-05 0.000801874579225714 EGFR/ATP2B1/ZFP36L1/ANXA1/ISL1/GSTP1/NR3C1/CFLAR/UBE2L3/USP8/REST/HNRNPU 12 GO:0006405 RNA export from nucleus 15/969 84/18722 2.37749870759633e-05 0.000812078970320159 NPM1/PABPN1/TPR/SETD2/RAN/HNRNPA1/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/IWS1/SSB 15 GO:0007163 establishment or maintenance of cell polarity 27/969 218/18722 2.39800183257119e-05 0.000813763479027081 ITGB1/RHOB/KANK1/DLG5/GJA1/DST/DOCK8/DLG1/ROCK1/JAM3/FRMD4A/FAT1/FERMT1/RICTOR/SLC9A1/RHOA/AMOT/AMOTL1/RHOBTB3/ARFGEF1/FLOT2/CDC42/GATA3/HES1/DYNLT1/ARF4/RHOC 27 GO:0030833 regulation of actin filament polymerization 23/969 171/18722 2.54903038338221e-05 0.000859434373132607 PFN1/IQGAP2/KANK1/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/TMSB10 23 GO:0032231 regulation of actin filament bundle assembly 17/969 105/18722 2.64462939736098e-05 0.000885950848115928 PFN1/MET/ACTG1/S100A10/WASF2/ROCK1/NRP1/PPP1R9A/SLC9A1/PIK3R1/RHOA/PPFIA1/CDC42/TACSTD2/ID1/RHOC/STMN1 17 GO:0090316 positive regulation of intracellular protein transport 22/969 160/18722 2.68801579426911e-05 0.00089474971597773 TCAF1/CDH1/ANK3/OAZ1/TPR/HUWE1/RAN/KIF5B/GLI3/PCM1/PIK3R1/UBR5/TCF7L2/NMT1/MAPK14/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/YWHAE 22 GO:0051893 regulation of focal adhesion assembly 13/969 66/18722 2.79945512247964e-05 0.000919630925739948 LRP1/ACTG1/MACF1/IQGAP1/S100A10/ROCK1/NRP1/PTPRA/SLC9A1/RHOA/MMP14/VCL/SLK 13 GO:0090109 regulation of cell-substrate junction assembly 13/969 66/18722 2.79945512247964e-05 0.000919630925739948 LRP1/ACTG1/MACF1/IQGAP1/S100A10/ROCK1/NRP1/PTPRA/SLC9A1/RHOA/MMP14/VCL/SLK 13 GO:0031503 protein-containing complex localization 27/969 220/18722 2.82469808458705e-05 0.000919630925739948 AKAP9/DAG1/DLG1/NPM1/PABPN1/TPR/SETD2/RAN/KIF5B/PURA/UPF2/PCM1/RAB11A/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/CLSTN1/XPO1/VAMP2/SFPQ/IWS1/EZR/HNRNPU/SSB 27 GO:0036293 response to decreased oxygen levels 35/969 322/18722 2.84321068829857e-05 0.000919630925739948 MALAT1/LDHA/CAV1/HSP90B1/ZFP36L1/SLC2A1/ENO1/TGFBR3/EGR1/PMAIP1/HP1BP3/NF1/EPAS1/SLC9A1/RHOA/SOD3/MMP14/DNMT3A/BMP7/SLC6A4/EP300/MDM4/P4HB/RBPJ/CFLAR/CITED2/TM9SF4/NPEPPS/DPP4/REST/CD24/HMOX1/STC2/PGK1/CCNB1 35 GO:0051146 striated muscle cell differentiation 32/969 283/18722 2.8507502864499e-05 0.000919630925739948 KRT19/KRT8/ITGB1/ACTG1/IGF2/PLEC/ISL1/AKAP13/GPX1/YBX1/TBX3/MORF4L2/BHLHE41/SLC9A1/MMP14/DDX39B/YY1/MAPK14/XBP1/RBPJ/CFLAR/HOMER1/MYOF/SPAG9/OBSL1/CDK1/KRAS/KLF5/CAV2/HNRNPU/CACYBP/CCNB1 32 GO:0003205 cardiac chamber development 22/969 161/18722 2.96433230336759e-05 0.000950404945852702 LRP2/NRP2/ADAMTS6/DSP/ADAMTS1/LMO4/SOX4/TRIP11/TGFBR3/ISL1/NRP1/HECTD1/LY6E/TBX3/JAG1/BMP7/MDM4/GJA5/RBPJ/CITED2/GATA3/HES1 22 GO:0072659 protein localization to plasma membrane 32/969 284/18722 3.05742745977209e-05 0.000974275360046885 EGFR/LRP1/GOLGA4/KRT18/CDH1/LAMA5/ITGB1/MACF1/S100A10/ANK3/DLG1/ROCK1/ANXA2/CLTC/DENND4C/HECTD1/KIF5B/ATP2B4/SPTBN1/MYL12A/RAB11A/PIK3R1/SORBS1/MMP14/LGALS3/PPFIA1/FLOT2/VAMP2/GOPC/EZR/TPBG/VAMP3 32 GO:0032386 regulation of intracellular transport 36/969 337/18722 3.18649442665994e-05 0.00100892677824537 TCAF1/CDH1/DYNC1H1/LMAN1/ANK3/ANXA2/PTPN14/GCC2/OAZ1/TPR/PGAP1/HUWE1/SETD2/RAN/KIF5B/GLI3/FERMT1/PCM1/PIK3R1/TXN/UBR5/PPP1R12A/TCF7L2/NMT1/MAPK14/SUPT6H/XPO1/TM9SF4/NPEPPS/UBE2L3/CDC42/VAMP2/CDK1/IWS1/EZR/YWHAE 36 GO:0006979 response to oxidative stress 44/969 446/18722 3.20478081111235e-05 0.00100892677824537 JUN/EGFR/FOS/LDHA/GPX3/APP/MET/RHOB/RPS3/ANXA1/PRDX6/PRDX1/GPX4/HSPB1/DHRS2/TRA2B/DUSP1/GSTP1/PPIA/GPX1/PARP1/BTG1/HSPA1A/DHCR24/EPAS1/FUT8/MCL1/TXN/SOD3/MMP14/PAWR/BMP7/SETX/P4HB/CHD6/IDH1/NFE2L1/REST/GCLM/HSPA1B/CDK1/SFPQ/HMOX1/NDUFA6 44 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 12/969 58/18722 3.38579032278698e-05 0.00105697974736089 CAV1/RPL26/RPL11/RPS3/BCLAF1/PMAIP1/S100A9/MCL1/EIF5A/SIAH1/DDIT3/SFPQ 12 GO:0007229 integrin-mediated signaling pathway 17/969 107/18722 3.39786830380079e-05 0.00105697974736089 ITGB4/ITGA6/ITGAV/LAMA5/ITGB1/ADAMTS1/DST/CD63/PLPP3/NRP1/ITGB8/TLN1/FERMT1/PTPRA/FUT8/ITGB5/CDC42 17 GO:1901990 regulation of mitotic cell cycle phase transition 33/969 299/18722 3.51424696325673e-05 0.00108167734407174 EGFR/RPL26/APP/ZFP36L1/PBX1/ADAMTS1/PRKDC/BRD4/SOX4/ANXA1/DDB1/DUSP1/DLG1/TPR/USP47/CTDSPL/BRD7/RAB11A/EIF4G1/ANAPC11/ANKRD17/TAOK3/FOXN3/TAOK1/WAC/NEK6/UBE2C/PSME2/XPC/CDK1/LCMT1/CCNB1/AURKA 33 GO:0034329 cell junction assembly 42/969 420/18722 3.51865955782999e-05 0.00108167734407174 LRP1/CAV1/ITGB4/CDH1/ITGA6/LAMC1/APP/ACTG1/MACF1/IQGAP1/DLG5/GJA1/DST/CTNND1/PLEC/S100A10/DLG1/ROCK1/NRP1/PKN2/JAM3/CLDN4/PPP1R9A/TLN1/PTPRA/EIF4G1/SLC9A1/RHOA/PLXNB1/SORBS1/MMP14/VCL/GJA5/SETD5/CLSTN1/SLK/CDC42/OBSL1/TPBG/RAB17/RHOC/CLDN7 42 GO:0010498 proteasomal protein catabolic process 47/969 490/18722 3.54716286178439e-05 0.00108406275530323 CAV1/HSP90B1/HSPA5/RPL11/DDB1/NHLRC3/EIF3H/GPX1/UFL1/SKP1/HECTD1/PMAIP1/HSPA1A/HUWE1/KLHL42/NEMF/DDA1/TBL1X/SEL1L/ANAPC11/GNA12/DNAJB14/CCDC47/WAC/PSMD1/PSMD8/SIAH1/FAF2/PCBP2/PSMB3/XPO1/TMEM259/DDIT3/SIAH2/UBE2C/PSME2/TMF1/UBXN4/HSPA1B/PSMA5/PSMB7/CDC20/PSMC1/PSMA1/UBE2A/TAF9/AURKA 47 GO:0055117 regulation of cardiac muscle contraction 14/969 77/18722 3.58045498068755e-05 0.00108787544936472 AKAP9/CAV1/DSP/GSTO1/DLG1/DSG2/DSC2/PDE4B/SLC9A1/DMD/CALM1/GJA5/CALM2/SRI 14 GO:1905475 regulation of protein localization to membrane 23/969 175/18722 3.69883620678319e-05 0.00111734786223404 TCAF1/EGFR/LRP1/DAG1/ITGB1/ANK3/DLG1/CLTC/HECTD1/KIF5B/ATP2B4/SLC5A3/SPTBN1/RAB11A/PIK3R1/SORBS1/MMP14/LGALS3/NMT1/GPC1/PPFIA1/GOPC/EZR 23 GO:0034446 substrate adhesion-dependent cell spreading 17/969 108/18722 3.84138442654788e-05 0.00115373994328386 LAMB1/ITGAV/LAMC1/LAMA5/FBLN1/KANK1/S100A10/NRP1/PIK3R1/RHOA/TRIOBP/ACTN4/P4HB/RREB1/CDC42/TACSTD2/VAMP3 17 GO:0002183 cytoplasmic translational initiation 9/969 34/18722 4.16750376058512e-05 0.00123287613454022 RPL13A/EIF3A/EIF2S2/EIF3H/EIF4G1/EIF3I/EIF3F/EIF4H/EIF4B 9 GO:0086004 regulation of cardiac muscle cell contraction 9/969 34/18722 4.16750376058512e-05 0.00123287613454022 AKAP9/CAV1/DSP/DLG1/DSG2/DSC2/PDE4B/GJA5/SRI 9 GO:0050673 epithelial cell proliferation 43/969 437/18722 4.17564247634173e-05 0.00123287613454022 EGFR/NRP2/CAV1/LAMB1/LAMC1/ZFP36L1/LGR5/GRN/IGF2/PRKDC/GJA1/NR2F2/LGR4/TGFBR3/CDK6/ISL1/DLG1/MAGED1/NRP1/GPX1/NF1/KDM5B/FERMT1/PURA/RICTOR/TCF7L2/MMP14/SERPINB1/NFIB/XBP1/RREB1/CFLAR/HTRA1/RTN4/CDC42/SRSF6/PDCD6/EMC10/ID1/GATA3/HMOX1/CAV2/HES1 43 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 19/969 131/18722 4.44633121979689e-05 0.00130542286262127 PEG10/FBN1/FBN2/CAV1/HSPA5/GLG1/TGFBR3/LTBP1/ZNF451/HSPA1A/FERMT1/TRIM33/LATS2/EP300/NREP/CFLAR/HTRA1/CITED2/CAV2 19 GO:0032868 response to insulin 30/969 264/18722 4.5694731367852e-05 0.00132303283604661 ATP2B1/ZFP36L1/KANK1/IGF2/PRKDC/PKM/SLC2A1/SRSF5/EGR1/GSTP1/IGF1R/PARP1/PHIP/DENND4C/VPS13C/PTPRA/GAB1/SLC9A1/PIK3R1/ZNF106/SORBS1/ESRRA/XBP1/CFLAR/PTPRE/SRSF6/VAMP2/HADHA/GGH/CAV2 30 GO:0098901 regulation of cardiac muscle cell action potential 8/969 27/18722 4.59978620617475e-05 0.00132303283604661 AKAP9/CAV1/DSP/DLG1/DSG2/DSC2/CALM1/GJA5 8 GO:0008360 regulation of cell shape 21/969 154/18722 4.60262904990614e-05 0.00132303283604661 ALDOA/DAG1/MYH10/RHOB/ANXA1/RASA1/DLG1/MYL12B/PHIP/FMNL2/DIAPH1/BRWD1/MYL12A/RHOA/ARHGAP18/PLXNB1/PRPF40A/RHOBTB3/EPS8/EZR/RHOC 21 GO:0046034 ATP metabolic process 31/969 277/18722 4.60757704095836e-05 0.00132303283604661 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/TMSB4X/COX6A1/PARP1/UQCRH/HSPA1A/COX8C/RHOA/NCOR1/COX5A/EP300/UQCRQ/COX7B/HSPA1B/CDK1/PGAM1/OLA1/DNAJC15/GHITM/STOML2/NDUFA6/PGK1/AK2/CCNB1/SDHC 31 GO:0042692 muscle cell differentiation 39/969 384/18722 4.72074090502705e-05 0.00134811977976346 KRT19/KRT8/ITGB1/ACTG1/IGF2/PLEC/ISL1/AKAP13/GPX1/YBX1/TBX3/MORF4L2/BHLHE41/SLC9A1/ANKRD17/MMP14/DMD/DDX39B/YY1/MAPK14/XBP1/ACTN4/RBPJ/SUPT6H/CFLAR/HOMER1/MYOF/SPAG9/QKI/OBSL1/AFG3L2/CDK1/KRAS/KLF5/CAV2/HES1/HNRNPU/CACYBP/CCNB1 39 GO:1902904 negative regulation of supramolecular fiber organization 22/969 166/18722 4.76644394139919e-05 0.00135377369770392 PFN1/MET/KANK1/WASF2/TMSB4X/PPP1R9A/KANK4/SCIN/SPTBN1/SPTAN1/PIK3R1/CAMSAP2/SVIL/TRIOBP/TAOK1/PPFIA1/ARFGEF1/EPS8/ADD3/TMSB10/TACSTD2/STMN1 22 GO:0009755 hormone-mediated signaling pathway 24/969 190/18722 4.85346574161471e-05 0.00136366730998271 LGR5/DDX5/LGR4/DDX17/ISL1/UFL1/PARP1/PTGES3/PRLR/ARID1A/CSNK2B/ESRRG/RHOA/NCOR1/LATS2/NR3C1/UBR5/FOXP1/ESRRA/BMP7/EP300/RXRA/TMF1/LBH 24 GO:0030041 actin filament polymerization 24/969 190/18722 4.85346574161471e-05 0.00136366730998271 PFN1/IQGAP2/KANK1/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/DIAPH1/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/TMSB10 24 GO:1901653 cellular response to peptide 37/969 359/18722 5.37629439124311e-05 0.00150248740580944 FBN1/ATP2B1/LRP1/CAV1/APP/ZFP36L1/KANK1/IGF2/PRKDC/PKM/GJA1/CYP11A1/SRSF5/ROCK1/GSTP1/IGF1R/PARP1/PHIP/DENND4C/PTPRA/GAB1/CSH1/SLC9A1/PIK3R1/ZNF106/SORBS1/AKR1B1/ESRRA/XBP1/AHCYL1/CFLAR/PTPRE/VAMP2/ID1/KLF5/CAV2/CASP4 37 GO:0035051 cardiocyte differentiation 21/969 156/18722 5.57820760394375e-05 0.00155062302862819 EGFR/ITGB1/PLEC/TGFBR3/ISL1/AKAP13/TBX3/SLC9A1/JAG1/DDX39B/YY1/BMP7/RBPJ/CITED2/OBSL1/REST/CDK1/HES1/HNRNPU/CACYBP/CCNB1 21 GO:1990778 protein localization to cell periphery 35/969 333/18722 5.70009054490869e-05 0.0015761202744811 EGFR/LRP1/CAV1/GOLGA4/KRT18/CDH1/DAG1/LAMA5/ITGB1/MACF1/S100A10/ANK3/DLG1/ROCK1/ANXA2/CLTC/DENND4C/HECTD1/KIF5B/ATP2B4/SPTBN1/MYL12A/RAB11A/PIK3R1/SORBS1/MMP14/LGALS3/PPFIA1/CLSTN1/FLOT2/VAMP2/GOPC/EZR/TPBG/VAMP3 35 GO:0071384 cellular response to corticosteroid stimulus 12/969 61/18722 5.73236940701741e-05 0.00157670329058279 EGFR/ATP2B1/ZFP36L1/ANXA1/ISL1/GSTP1/NR3C1/CFLAR/UBE2L3/USP8/REST/HNRNPU 12 GO:0060147 regulation of posttranscriptional gene silencing 11/969 52/18722 5.76876986056862e-05 0.00157840792101213 NEAT1/EGFR/KCNQ1OT1/DDX5/PUM1/TNRC6B/EIF4G1/NCOR1/PUM2/ADAR/AGO2 11 GO:0045056 transcytosis 7/969 21/18722 5.96900721082095e-05 0.00162468915019533 LRP2/LRP1/CLTC/IGF1R/RAB11A/LRPAP1/RAB17 7 GO:0060348 bone development 25/969 205/18722 6.12817101142397e-05 0.00165182260742915 FBN1/RPL13/GLG1/GJA1/TRIP11/BBX/WASF2/ANXA2/AKAP13/LRP5/GLI3/RHOA/PLXNB1/FOXP1/SMAD5/SLC38A10/TFAP2A/FOXN3/MMP14/LTBP3/MAPK14/EP300/TMEM107/CITED2/SERPINH1 25 GO:0002262 myeloid cell homeostasis 21/969 157/18722 6.13190941142852e-05 0.00165182260742915 RPS6/ZFP36L1/PRKDC/ANXA1/TGFBR3/PRDX1/CDK6/UFL1/JAM3/HSPA1A/EPAS1/RCOR1/PDE4B/SMAD5/ADAR/MAPK14/CITED2/HSPA1B/GATA3/HMOX1/PRMT1 21 GO:0003281 ventricular septum development 13/969 71/18722 6.25983988609326e-05 0.00167763708947299 LRP2/LMO4/SOX4/TRIP11/TGFBR3/HECTD1/TBX3/MDM4/GJA5/RBPJ/CITED2/GATA3/HES1 13 GO:0010452 histone H3-K36 methylation 6/969 15/18722 6.32732813208964e-05 0.00168707228664798 BRD4/ASH1L/SETD2/NSD1/SETD5/IWS1 6 GO:1901987 regulation of cell cycle phase transition 39/969 390/18722 6.62123888978426e-05 0.00175647687502602 EGFR/RPL26/APP/ZFP36L1/PBX1/ADAMTS1/PRKDC/BRD4/SOX4/ANXA1/DDB1/PPP1R10/DUSP1/DLG1/NPM1/TPR/USP47/CTDSPL/ATP2B4/BRD7/RAB11A/EIF4G1/ANAPC11/ANKRD17/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/NEK6/UBE2C/PSME2/XPC/CDK1/LCMT1/CCNB1/AURKA 39 GO:1903078 positive regulation of protein localization to plasma membrane 12/969 62/18722 6.77739852062503e-05 0.00178882245801952 EGFR/LRP1/ITGB1/DLG1/KIF5B/ATP2B4/SPTBN1/RAB11A/PIK3R1/SORBS1/LGALS3/EZR 12 GO:0060966 regulation of gene silencing by RNA 11/969 53/18722 6.94282871184736e-05 0.001823277530056 NEAT1/EGFR/KCNQ1OT1/DDX5/PUM1/TNRC6B/EIF4G1/NCOR1/PUM2/ADAR/AGO2 11 GO:0043401 steroid hormone mediated signaling pathway 19/969 136/18722 7.48468237435733e-05 0.00194919317160016 DDX5/DDX17/ISL1/UFL1/PARP1/PTGES3/ARID1A/ESRRG/RHOA/NCOR1/NR3C1/UBR5/FOXP1/ESRRA/BMP7/EP300/RXRA/TMF1/LBH 19 GO:0044706 multi-multicellular organism process 26/969 220/18722 7.49689681384676e-05 0.00194919317160016 FOS/ITGB4/FOSB/RPL29/FBLN1/SLC2A1/GJA1/NR2F2/ASH1L/SLC38A1/SLC38A2/PRLR/CLDN4/JUNB/CTSV/AKR1B1/AGO2/SLC6A4/CITED2/MAGED2/KPNA6/KRAS/SLC19A1/STC2/HPGD/UBE2A 26 GO:1904375 regulation of protein localization to cell periphery 18/969 125/18722 7.69903847661128e-05 0.00199184035043419 EGFR/LRP1/DAG1/ITGB1/DLG1/CLTC/HECTD1/KIF5B/ATP2B4/SPTBN1/RAB11A/PIK3R1/SORBS1/MMP14/LGALS3/PPFIA1/GOPC/EZR 18 GO:0035272 exocrine system development 10/969 45/18722 8.01783190953562e-05 0.002064098007844 DAG1/LAMA5/WLS/IGF2/NRP1/IGSF3/NFIB/BMP7/TFCP2L1/CDC42 10 GO:0007051 spindle organization 23/969 184/18722 8.13982690662378e-05 0.00207506026409833 DYNC1H1/ATRX/RPS3/DLG1/CLTC/TACC2/TPR/HSPA1A/RAN/RAB11A/RHOA/NCOR1/KPNB1/NEK6/STAG1/UVRAG/HSPA1B/EZR/HNRNPU/CDC20/CCNB1/STMN1/AURKA 23 GO:0055001 muscle cell development 23/969 184/18722 8.13982690662378e-05 0.00207506026409833 KRT19/KRT8/ITGB1/ACTG1/PLEC/ISL1/AKAP13/GPX1/TBX3/DMD/DDX39B/YY1/ACTN4/CFLAR/HOMER1/MYOF/OBSL1/AFG3L2/CDK1/CAV2/HES1/HNRNPU/CCNB1 23 GO:0001503 ossification 40/969 408/18722 8.28916216398044e-05 0.00210287191596902 RRBP1/FBN2/EGFR/SLC26A2/ATP2B1/JUND/CRIM1/PBX1/IGF2/DDX5/LGR4/CDK6/IL6ST/LRP5/CLTC/UFL1/NIPBL/SUCO/GLI3/NF1/SMOC1/RHOA/JUNB/PLXNB1/SMAD5/CLIC1/TFAP2A/JAG1/MMP14/CCDC47/ADAR/LTBP3/ESRRA/BMP7/MAPK14/RBPJ/REST/TPM4/HNRNPC/HNRNPU 40 GO:2000114 regulation of establishment of cell polarity 7/969 22/18722 8.36487804346748e-05 0.00211182863068411 KANK1/DOCK8/ROCK1/RICTOR/ARFGEF1/FLOT2/GATA3 7 GO:0030099 myeloid cell differentiation 38/969 381/18722 8.64017776118542e-05 0.00216547672617197 FBN1/JUN/FOS/CSF3R/RPS6/APP/ZFP36L1/PRKDC/TGFBR3/CDK6/DHRS2/WASF2/ANXA2/TET2/UFL1/PARP1/HSPA1A/ITGB8/SCIN/TFRC/EPAS1/RCOR1/PIK3R1/JUNB/FOXP1/SMAD5/JAG1/ADAR/ESRRA/MAPK14/EP300/RBPJ/CITED2/NFKBIA/CDC42/HSPA1B/GATA3/PRMT1 38 GO:0051592 response to calcium ion 20/969 149/18722 8.6602494406801e-05 0.00216547672617197 EGFR/FOS/CAV1/FUS/JUND/FOSB/HSPA5/IQGAP1/DUSP1/SYT7/SEC31A/JUNB/TRPV6/CALM1/WNK1/AHCYL1/HOMER1/PDCD6/CALM2/CACYBP 20 GO:0051099 positive regulation of binding 22/969 173/18722 8.92370116296314e-05 0.00222072677512597 LRP1/CAV1/APP/MET/RPL11/S100A10/ISL1/ANXA2/NRP1/PARP1/RAN/EIF4G1/TXN/TCF7L2/CALM1/EP300/SPPL3/EDF1/GATA3/CALM2/HES1/STMN1 22 GO:0003012 muscle system process 43/969 452/18722 9.09234803066642e-05 0.00225197207622098 ALDOA/AKAP9/ATP2B1/CAV1/DAG1/UTRN/DSP/GSTO1/GJA1/ENO1/IL6ST/GAA/DLG1/ROCK1/AKAP13/MYL6/DSG2/PABPN1/PARP1/TBX3/ATP2B4/DSC2/PDE4B/SLC9A1/RHOA/JARID2/ASPH/SMAD5/DMD/CALM1/DDX39B/YY1/SSPN/GJA5/CFLAR/HOMER1/MYOF/CAMK2G/CALD1/TPM4/HMOX1/CALM2/SRI 43 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 6/969 16/18722 9.68105323803411e-05 0.00238647095386633 ANK3/KIF5B/SLC9A1/DMD/WNK1/ACTN4 6 GO:0003151 outflow tract morphogenesis 13/969 74/18722 9.76713057040234e-05 0.00239638612023111 LRP2/NRP2/TGFBR3/ISL1/NRP1/NIPBL/TBX3/JAG1/BMP7/GJA5/RBPJ/CITED2/HES1 13 GO:0061614 pri-miRNA transcription by RNA polymerase II 11/969 55/18722 9.91405090090208e-05 0.00242106682280908 JUN/FOS/DDX5/EGR1/TEAD1/NR3C1/NFIB/YY1/REST/GATA3/KLF5 11 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 40/969 412/18722 0.000102396904098171 0.0024889591665909 CAV1/HSP90B1/HSPA5/RPL11/DDB1/NHLRC3/EIF3H/UFL1/SKP1/HECTD1/HSPA1A/HUWE1/KLHL42/NEMF/DDA1/TBL1X/SEL1L/ANAPC11/GNA12/DNAJB14/CCDC47/WAC/PSMD1/PSMD8/SIAH1/FAF2/PCBP2/PSMB3/XPO1/DDIT3/SIAH2/UBE2C/UBXN4/HSPA1B/PSMA5/CDC20/PSMC1/UBE2A/TAF9/AURKA 40 GO:0008064 regulation of actin polymerization or depolymerization 23/969 187/18722 0.000104392252239551 0.00249287525855791 PFN1/IQGAP2/KANK1/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/TMSB10 23 GO:0048592 eye morphogenesis 20/969 151/18722 0.00010446606996253 0.00249287525855791 FBN1/FBN2/TENM3/TUG1/LRP5/NIPBL/FAT1/GLI3/NF1/EFEMP1/AHI1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/MFAP5 20 GO:0071456 cellular response to hypoxia 20/969 151/18722 0.00010446606996253 0.00249287525855791 MALAT1/ZFP36L1/ENO1/EGR1/PMAIP1/HP1BP3/EPAS1/SLC9A1/DNMT3A/BMP7/MDM4/P4HB/RBPJ/CFLAR/CITED2/NPEPPS/HMOX1/STC2/PGK1/CCNB1 20 GO:2001236 regulation of extrinsic apoptotic signaling pathway 20/969 151/18722 0.00010446606996253 0.00249287525855791 CAV1/ITGA6/ITGAV/GSTP1/NRP1/GPX1/PHIP/BIRC6/PMAIP1/HSPA1A/RB1CC1/MCL1/TCF7L2/LGALS3/PDIA3/CFLAR/SIAH2/GCLM/HSPA1B/HMOX1 20 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 18/969 128/18722 0.000105250573992113 0.00250017954401266 PEG10/FBN1/FBN2/CAV1/HSPA5/GLG1/TGFBR3/LTBP1/ZNF451/HSPA1A/FERMT1/TRIM33/LATS2/EP300/NREP/HTRA1/CITED2/CAV2 18 GO:0090263 positive regulation of canonical Wnt signaling pathway 16/969 106/18722 0.000107656570757971 0.0025342938683836 EGFR/CAV1/RPS12/KANK1/LGR5/WLS/SOX4/LGR4/USP34/USP47/TBL1X/UBR5/WNK1/RBPJ/USP8/ATP6AP2 16 GO:1905477 positive regulation of protein localization to membrane 16/969 106/18722 0.000107656570757971 0.0025342938683836 TCAF1/EGFR/LRP1/ITGB1/ANK3/DLG1/KIF5B/ATP2B4/SLC5A3/SPTBN1/RAB11A/PIK3R1/SORBS1/LGALS3/NMT1/EZR 16 GO:0048524 positive regulation of viral process 12/969 65/18722 0.000109550697046349 0.00256731812898753 DDB1/PPIA/PKN2/HACD3/RSF1/LARP1/ADAR/P4HB/PABPC1/KPNA6/CAV2/KPNA2 12 GO:0030832 regulation of actin filament length 23/969 188/18722 0.000113250222720754 0.00264216814258329 PFN1/IQGAP2/KANK1/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/TMSB10 23 GO:2000737 negative regulation of stem cell differentiation 7/969 23/18722 0.000114897278103413 0.00266868077941528 N4BP2L2/JAG1/CDK12/REST/LBH/HES1/HNRNPU 7 GO:0034101 erythrocyte homeostasis 18/969 129/18722 0.000116515046523126 0.00269428156252149 RPS6/ZFP36L1/PRKDC/TGFBR3/PRDX1/CDK6/UFL1/HSPA1A/EPAS1/RCOR1/SMAD5/ADAR/MAPK14/CITED2/HSPA1B/GATA3/HMOX1/PRMT1 18 GO:0030522 intracellular receptor signaling pathway 29/969 265/18722 0.000119073337839401 0.00274130953105159 DDX5/NR2F2/DDX17/ISL1/PUM1/UFL1/PARP1/PTGES3/HSPA1A/ARID1A/ESRRG/RHOA/NCOR1/NR3C1/UBR5/FOXP1/ANKRD17/PUM2/ESRRA/EP300/ACTN4/CITED2/NFKBIA/NR2F6/RXRA/TMF1/HSPA1B/TRIM24/LBH 29 GO:0031100 animal organ regeneration 13/969 76/18722 0.000129532107333952 0.00295702707467055 EGFR/RPL19/RPS16/TGFBR3/SRSF5/GSTP1/GLI3/UPF2/CSNK2B/CDK1/HMOX1/ANXA3/AURKA 13 GO:0070482 response to oxygen levels 35/969 347/18722 0.00013001085249224 0.00295702707467055 MALAT1/LDHA/CAV1/HSP90B1/ZFP36L1/SLC2A1/ENO1/TGFBR3/EGR1/PMAIP1/HP1BP3/NF1/EPAS1/SLC9A1/RHOA/SOD3/MMP14/DNMT3A/BMP7/SLC6A4/EP300/MDM4/P4HB/RBPJ/CFLAR/CITED2/TM9SF4/NPEPPS/DPP4/REST/CD24/HMOX1/STC2/PGK1/CCNB1 35 GO:0001765 membrane raft assembly 5/969 11/18722 0.000130706707663394 0.00295702707467055 CAV1/S100A10/ANXA2/FLOT2/CAV2 5 GO:0098935 dendritic transport 5/969 11/18722 0.000130706707663394 0.00295702707467055 KIF5B/PURA/FLOT2/SFPQ/HNRNPU 5 GO:1903115 regulation of actin filament-based movement 9/969 39/18722 0.000133360761921074 0.00300406612844627 AKAP9/CAV1/DSP/DLG1/DSG2/DSC2/PDE4B/GJA5/SRI 9 GO:0032869 cellular response to insulin stimulus 24/969 203/18722 0.000138799545539376 0.00311316062226943 ATP2B1/ZFP36L1/KANK1/IGF2/PRKDC/PKM/SRSF5/GSTP1/IGF1R/PARP1/PHIP/DENND4C/PTPRA/GAB1/SLC9A1/PIK3R1/ZNF106/SORBS1/ESRRA/XBP1/CFLAR/PTPRE/VAMP2/CAV2 24 GO:0019827 stem cell population maintenance 18/969 131/18722 0.000142263949547472 0.00317052020522207 TPT1/ZC3H13/SOX4/NCOA3/LRP5/RIF1/NIPBL/TBX3/PCM1/JAG1/MTF2/BMP7/RBPJ/RTF1/HOOK3/REST/LBH/HES1 18 GO:0048041 focal adhesion assembly 14/969 87/18722 0.000142570273292611 0.00317052020522207 LRP1/ACTG1/MACF1/IQGAP1/S100A10/ROCK1/NRP1/PTPRA/SLC9A1/RHOA/SORBS1/MMP14/VCL/SLK 14 GO:0030010 establishment of cell polarity 19/969 143/18722 0.000147764941798657 0.00326256543674013 ITGB1/KANK1/GJA1/DOCK8/ROCK1/JAM3/FRMD4A/FAT1/FERMT1/RICTOR/RHOA/AMOT/AMOTL1/ARFGEF1/FLOT2/CDC42/GATA3/HES1/DYNLT1 19 GO:0007052 mitotic spindle organization 17/969 120/18722 0.000147957904421625 0.00326256543674013 DYNC1H1/CLTC/TACC2/TPR/HSPA1A/RAN/RAB11A/RHOA/KPNB1/NEK6/STAG1/HSPA1B/HNRNPU/CDC20/CCNB1/STMN1/AURKA 17 GO:0061337 cardiac conduction 15/969 98/18722 0.000149255079245506 0.00327734052158409 AKAP9/ATP2B1/CAV1/DSP/GJA1/ISL1/DSG2/ATP2B4/DSC2/SLC9A1/CALM1/GJA5/YWHAE/CALM2/SRI 15 GO:0008154 actin polymerization or depolymerization 25/969 217/18722 0.000153735279435713 0.00336159234448132 PFN1/IQGAP2/KANK1/CFL1/RASA1/WASF2/ARPC3/DLG1/TMSB4X/PPP1R9A/DIAPH1/KANK4/SCIN/RICTOR/SPTBN1/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/ARFGEF1/EPS8/ADD3/TMSB10 25 GO:0043666 regulation of phosphoprotein phosphatase activity 11/969 58/18722 0.000163703908553297 0.00355632457673807 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/ROCK1/CSNK2B/PPP1R12A/PPP6R2/LGALS3/CALM1/CALM2 11 GO:0045931 positive regulation of mitotic cell cycle 17/969 121/18722 0.000164001956179463 0.00355632457673807 EGFR/APP/PBX1/ADAMTS1/BRD4/ANXA1/PPP1R10/PKN2/RAB11A/EIF4G1/ANAPC11/ANKRD17/USP22/UBE2C/CDK1/HES1/CCNB1 17 GO:0060964 regulation of gene silencing by miRNA 10/969 49/18722 0.000171157831677422 0.00367803577984155 NEAT1/EGFR/KCNQ1OT1/DDX5/PUM1/TNRC6B/EIF4G1/NCOR1/PUM2/AGO2 10 GO:0032922 circadian regulation of gene expression 12/969 68/18722 0.000171726125197348 0.00367803577984155 MYCBP2/LGR4/ZFHX3/EGR1/MAGED1/KDM5A/HUWE1/BHLHE41/NRIP1/KDM2A/ID1/HNRNPU 12 GO:0060411 cardiac septum morphogenesis 12/969 68/18722 0.000171726125197348 0.00367803577984155 LRP2/NRP2/SOX4/TGFBR3/ISL1/NRP1/TBX3/JAG1/BMP7/RBPJ/CITED2/HES1 12 GO:0051497 negative regulation of stress fiber assembly 8/969 32/18722 0.000173049428318352 0.00369125025466004 PFN1/MET/WASF2/PPP1R9A/PIK3R1/PPFIA1/TACSTD2/STMN1 8 GO:0050678 regulation of epithelial cell proliferation 37/969 381/18722 0.000182761219610485 0.00388256151904225 EGFR/NRP2/CAV1/LAMB1/LAMC1/ZFP36L1/GRN/IGF2/PRKDC/GJA1/NR2F2/TGFBR3/CDK6/ISL1/DLG1/MAGED1/NRP1/GPX1/NF1/KDM5B/RICTOR/TCF7L2/NFIB/XBP1/RREB1/CFLAR/HTRA1/RTN4/CDC42/SRSF6/PDCD6/EMC10/ID1/GATA3/HMOX1/CAV2/HES1 37 GO:0061640 cytoskeleton-dependent cytokinesis 15/969 100/18722 0.000187951123878444 0.0039766500946913 SON/MYH10/RHOB/RASA1/PLEC/ANK3/ROCK1/SPTBN1/RHOA/SNX18/USP8/JTB/NUSAP1/RHOC/STMN1 15 GO:0098727 maintenance of cell number 18/969 134/18722 0.000190234654038045 0.00400873508872107 TPT1/ZC3H13/SOX4/NCOA3/LRP5/RIF1/NIPBL/TBX3/PCM1/JAG1/MTF2/BMP7/RBPJ/RTF1/HOOK3/REST/LBH/HES1 18 GO:0006406 mRNA export from nucleus 11/969 59/18722 0.000191932926842977 0.00400945147431377 PABPN1/TPR/SETD2/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/IWS1 11 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 11/969 59/18722 0.000191932926842977 0.00400945147431377 PABPN1/TPR/SETD2/UPF2/SMG1/THOC2/ZC3H11A/DDX39B/YTHDC1/SUPT6H/IWS1 11 GO:0032535 regulation of cellular component size 37/969 382/18722 0.000192570287036501 0.00400945147431377 LRP1/GOLGA4/SEMA6A/PFN1/IQGAP2/KANK1/MACF1/SEMA6D/RASA1/PPP1R15A/WASF2/ARPC3/DLG1/NPM1/NRP1/TMSB4X/PPP1R9A/HP1BP3/KANK4/KCNN4/SCIN/RB1CC1/RICTOR/SPTBN1/RAB11A/SPTAN1/RHOA/ARHGAP18/SVIL/TRIOBP/COTL1/RTN4/ARFGEF1/EPS8/ADD3/TMSB10/EZR 37 GO:0006446 regulation of translational initiation 13/969 79/18722 0.000193957819952892 0.00402231574235641 RPL13A/PPP1R15A/HSPB1/NPM1/EIF3H/TPR/EIF4G1/EIF1/LARP1/AGO2/EIF2AK4/EIF4H/EIF4B 13 GO:0045665 negative regulation of neuron differentiation 12/969 69/18722 0.000198231446350262 0.00407857298671838 APP/PBX1/ISL1/GLI3/RHOA/JAG1/BMP7/SLC6A4/EIF2AK4/SPAG9/REST/HES1 12 GO:1904377 positive regulation of protein localization to cell periphery 12/969 69/18722 0.000198231446350262 0.00407857298671838 EGFR/LRP1/ITGB1/DLG1/KIF5B/ATP2B4/SPTBN1/RAB11A/PIK3R1/SORBS1/LGALS3/EZR 12 GO:0003231 cardiac ventricle development 17/969 123/18722 0.000200701685431019 0.0041132039531863 LRP2/DSP/LMO4/SOX4/TRIP11/TGFBR3/ISL1/HECTD1/LY6E/TBX3/JAG1/MDM4/GJA5/RBPJ/CITED2/GATA3/HES1 17 GO:0032878 regulation of establishment or maintenance of cell polarity 7/969 25/18722 0.000205718445395199 0.00417916866784906 KANK1/DOCK8/ROCK1/RICTOR/ARFGEF1/FLOT2/GATA3 7 GO:0034109 homotypic cell-cell adhesion 14/969 90/18722 0.000206319463510344 0.00417916866784906 ACTG1/DSP/HSPB1/IL6ST/PLPP3/ANK3/DSG2/PPIA/TLN1/MYL12A/DSC2/CD99/CLIC1/VCL 14 GO:0035304 regulation of protein dephosphorylation 14/969 90/18722 0.000206319463510344 0.00417916866784906 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/ROCK1/PPIA/CSNK2B/PPP1R12A/PPP6R2/LGALS3/CALM1/SPPL3/YWHAE/CALM2 14 GO:0051170 import into nucleus 20/969 159/18722 0.000212783076884647 0.0042934531266377 CDH1/PPP1R10/RANBP2/TPR/RAN/GLI3/FERMT1/HNRNPA1/PIK3R1/FAM53C/TNPO1/UBR5/KPNB1/MAPK14/NFKBIA/KPNA6/CDK1/PTTG1IP/KPNA2/SEC13 20 GO:0098911 regulation of ventricular cardiac muscle cell action potential 5/969 12/18722 0.000214524630899743 0.00431194508108482 CAV1/DSP/DLG1/DSG2/DSC2 5 GO:0034599 cellular response to oxidative stress 30/969 288/18722 0.000220146584735762 0.00440799253574365 JUN/EGFR/FOS/MET/RHOB/RPS3/ANXA1/PRDX1/HSPB1/DHRS2/PPIA/GPX1/PARP1/HSPA1A/EPAS1/FUT8/MCL1/TXN/SOD3/PAWR/BMP7/SETX/P4HB/CHD6/NFE2L1/REST/HSPA1B/CDK1/SFPQ/HMOX1 30 GO:0042770 signal transduction in response to DNA damage 21/969 172/18722 0.000227313207127563 0.00453411763530017 RPL26/MIF/ATRX/PRKDC/DDX5/SOX4/PPP1R10/NPM1/PMAIP1/USP10/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/MDM4/XPC/CDK1/PTTG1IP 21 GO:0003158 endothelium development 18/969 136/18722 0.000229579748987138 0.00456191546846685 MET/RHOB/GJA1/NR2F2/ROCK1/NRP1/GPX1/BTG1/CSNK2B/RHOA/FOXP1/JAG1/VCL/GJA5/RBPJ/EDF1/ID1/EZR 18 GO:0071214 cellular response to abiotic stimulus 33/969 331/18722 0.000248006199077858 0.00487537340606686 EGFR/RPL26/DAG1/HSPA5/ZFP36L1/RHOB/SLC2A1/GJA1/DDB1/PLEC/EGR1/NPM1/SLC38A2/PARP1/NIPBL/USP47/TMEM150C/SLC9A1/PIK3R1/AKR1B1/EFHD1/YY1/NMT1/MAPK14/EP300/EIF2AK4/ADIRF/MME/REST/XPC/EEF1D/GATA3/SERPINB6 33 GO:0104004 cellular response to environmental stimulus 33/969 331/18722 0.000248006199077858 0.00487537340606686 EGFR/RPL26/DAG1/HSPA5/ZFP36L1/RHOB/SLC2A1/GJA1/DDB1/PLEC/EGR1/NPM1/SLC38A2/PARP1/NIPBL/USP47/TMEM150C/SLC9A1/PIK3R1/AKR1B1/EFHD1/YY1/NMT1/MAPK14/EP300/EIF2AK4/ADIRF/MME/REST/XPC/EEF1D/GATA3/SERPINB6 33 GO:0071375 cellular response to peptide hormone stimulus 30/969 290/18722 0.000248233430771302 0.00487537340606686 FBN1/ATP2B1/CAV1/ZFP36L1/KANK1/IGF2/PRKDC/PKM/CYP11A1/SRSF5/ROCK1/GSTP1/IGF1R/PARP1/PHIP/DENND4C/PTPRA/GAB1/CSH1/SLC9A1/PIK3R1/ZNF106/SORBS1/ESRRA/XBP1/AHCYL1/CFLAR/PTPRE/VAMP2/CAV2 30 GO:0060968 regulation of gene silencing 13/969 81/18722 0.000250748105292473 0.00487537340606686 NEAT1/EGFR/KCNQ1OT1/DDX5/PUM1/TNRC6B/TPR/MPHOSPH8/EIF4G1/NCOR1/PUM2/ADAR/AGO2 13 GO:0007266 Rho protein signal transduction 18/969 137/18722 0.000251787153883054 0.00487537340606686 ITGB1/MET/RHOB/KANK1/ADGRG1/CFL1/ROCK1/AKAP13/NRP1/EPS8L1/ARHGAP5/RHOA/ABCA1/HACD3/GNA12/CDC42/EPS8/STMN1 18 GO:0050714 positive regulation of protein secretion 18/969 137/18722 0.000251787153883054 0.00487537340606686 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ISL1/PPIA/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/EXPH5/TCF7L2/EZR/SRI 18 GO:0036294 cellular response to decreased oxygen levels 20/969 161/18722 0.000251884963574063 0.00487537340606686 MALAT1/ZFP36L1/ENO1/EGR1/PMAIP1/HP1BP3/EPAS1/SLC9A1/DNMT3A/BMP7/MDM4/P4HB/RBPJ/CFLAR/CITED2/NPEPPS/HMOX1/STC2/PGK1/CCNB1 20 GO:0042255 ribosome assembly 11/969 61/18722 0.000260886202306412 0.00503096418174653 RPLP0/RPL6/RPL23A/RPL24/RPL3/RPL11/RPL10/PRKDC/RPS5/RPSA/NPM1 11 GO:0003015 heart process 27/969 251/18722 0.00026651326866251 0.0051205821398172 AKAP9/ATP2B1/CAV1/CYP2J2/DSP/GSTO1/GJA1/GAA/ISL1/DLG1/AKAP13/DSG2/GPX1/ADRB1/ATP2B4/EPAS1/DSC2/PDE4B/SLC9A1/SMAD5/DMD/CALM1/GJA5/CDC42/YWHAE/CALM2/SRI 27 GO:1901989 positive regulation of cell cycle phase transition 16/969 115/18722 0.000283168600370282 0.00542065606423112 EGFR/APP/PBX1/ADAMTS1/BRD4/ANXA1/PPP1R10/NPM1/RAB11A/EIF4G1/ANAPC11/ANKRD17/DDX39B/UBE2C/CDK1/CCNB1 16 GO:0046794 transport of virus 6/969 19/18722 0.00028691097744117 0.00547225097849472 CAV1/CTSL/KPNA6/CAV2/DYNLT1/KPNA2 6 GO:0060993 kidney morphogenesis 14/969 93/18722 0.000293225123738271 0.00557234362420438 LAMA5/PBX1/SOX4/LGR4/FRAS1/DLG1/MAGED1/GLI3/AHI1/IRX2/BMP7/TACSTD2/GATA3/HES1 14 GO:1903036 positive regulation of response to wounding 12/969 72/18722 0.000299615752252092 0.00567315913503418 LRP1/ITGB1/ACTG1/KANK1/GRN/ANXA1/PLPP3/CLDN4/FERMT1/XBP1/RREB1/ARFGEF1 12 GO:0060047 heart contraction 26/969 241/18722 0.000328105988555179 0.00617396241638943 AKAP9/ATP2B1/CAV1/CYP2J2/DSP/GSTO1/GJA1/GAA/ISL1/DLG1/DSG2/GPX1/ADRB1/ATP2B4/EPAS1/DSC2/PDE4B/SLC9A1/SMAD5/DMD/CALM1/GJA5/CDC42/YWHAE/CALM2/SRI 26 GO:0061326 renal tubule development 14/969 94/18722 0.000328427392222783 0.00617396241638943 LAMA5/LGR5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/JAG1/TACSTD2/GATA3/CD24/HES1 14 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 5/969 13/18722 0.000333773658084584 0.00620747735640582 TNRC6B/TNRC6A/AGO2/BTG2/PABPC1 5 GO:1900115 extracellular regulation of signal transduction 5/969 13/18722 0.000333773658084584 0.00620747735640582 FBN1/FBN2/CD46/LTBP1/LRPAP1 5 GO:1900116 extracellular negative regulation of signal transduction 5/969 13/18722 0.000333773658084584 0.00620747735640582 FBN1/FBN2/CD46/LTBP1/LRPAP1 5 GO:0032232 negative regulation of actin filament bundle assembly 8/969 35/18722 0.000337312335443987 0.00621004555713835 PFN1/MET/WASF2/PPP1R9A/PIK3R1/PPFIA1/TACSTD2/STMN1 8 GO:0097421 liver regeneration 8/969 35/18722 0.000337312335443987 0.00621004555713835 EGFR/RPL19/RPS16/SRSF5/GLI3/CSNK2B/HMOX1/AURKA 8 GO:0071453 cellular response to oxygen levels 21/969 177/18722 0.000337476643365345 0.00621004555713835 MALAT1/CAV1/ZFP36L1/ENO1/EGR1/PMAIP1/HP1BP3/EPAS1/SLC9A1/DNMT3A/BMP7/MDM4/P4HB/RBPJ/CFLAR/CITED2/NPEPPS/HMOX1/STC2/PGK1/CCNB1 21 GO:0030900 forebrain development 36/969 379/18722 0.000339940547206896 0.0062334361393096 LRP2/NRP2/LRP1/CDH1/LAMB1/APP/ADGRG1/ATRX/SLC2A1/NR2F2/CDK6/TRA2B/ISL1/NRP1/TACC2/SLC38A2/PGAP1/SETD2/KIF5B/GLI3/NF1/TBX3/ATP2B4/PCM1/RHOA/CELF1/DNAJB1/NFIB/RBPJ/RTN4/HOOK3/UQCRQ/BTG2/KRAS/ANXA3/HES1 36 GO:0072594 establishment of protein localization to organelle 39/969 422/18722 0.000341545956812988 0.00624097611994642 CDH1/HSPA5/LMAN1/PPP1R10/GCC2/NIPBL/RANBP2/TPR/VPS13C/HUWE1/RAN/GLI3/ZFYVE16/FERMT1/RAB11A/SEC62/PIK3R1/FAM53C/VPS13A/TNPO1/GNPTAB/UBR5/CALM1/NMT1/KPNB1/RAB3GAP2/MAPK14/NFKBIA/DDIT3/NPEPPS/UBE2L3/KPNA6/CDK1/PTTG1IP/DNAJC15/NDUFA13/CCT8/KPNA2/SEC13 39 GO:1903362 regulation of cellular protein catabolic process 27/969 255/18722 0.000343469757551312 0.00625426116015038 LRP2/LRP1/CAV1/RPL11/CTSC/ANXA2/EIF3H/GPX1/UFL1/HECTD1/HSPA1A/DDA1/GNA12/WAC/VGLL4/XPO1/TMEM259/MYLIP/PSME2/TMF1/HSPA1B/EZR/PTTG1IP/CDC20/PSMC1/TAF9/AURKA 27 GO:0000027 ribosomal large subunit assembly 7/969 27/18722 0.000347077826907736 0.00629801640076329 RPLP0/RPL6/RPL23A/RPL24/RPL3/RPL11/RPL10 7 GO:1903320 regulation of protein modification by small protein conjugation or removal 26/969 242/18722 0.000349973563766513 0.00631594972209362 CAV1/HSPA5/RPS2/MYCBP2/RPL11/RPS20/RPS3/SOX4/EGR1/NPM1/TRIM44/PPIA/UFL1/SKP1/HSPA1A/HUWE1/EPAS1/UBR5/SIAH2/UBE2C/UBE2L3/PDCD6/HSPA1B/PTTG1IP/CDC20/HMG20B 26 GO:0045785 positive regulation of cell adhesion 40/969 437/18722 0.000350483241371441 0.00631594972209362 CAV1/CD46/ITGA6/ITGAV/CCDC80/DAG1/UTRN/NFAT5/ADGRG1/IQGAP1/IGF2/RPS3/SOX4/ANXA1/CDK6/S100A10/IL6ST/ZFHX3/PLPP3/ANK3/DOCK8/ROCK1/NRP1/GLI3/FERMT1/TFRC/GCNT2/RHOA/TRIOBP/BMP7/XBP1/P4HB/RREB1/CITED2/FLOT2/DPP4/CDC42/GATA3/CD24/HES1 40 GO:0046620 regulation of organ growth 15/969 106/18722 0.00036044299834704 0.0064731103414489 IGF2/GJA1/TGFBR3/DUSP6/LATS2/JARID2/DDX39B/YY1/MAPK14/SLC6A4/RBPJ/VGLL4/CITED2/CDK1/CCNB1 15 GO:0006325 chromatin organization 38/969 409/18722 0.000364817994387935 0.00652924259818955 BPTF/ATRX/BRD4/GPX4/RERE/NPM1/BAZ1B/BRD2/KDM5A/TPR/ARID4B/HP1BP3/ARID1A/SETD2/SMARCA2/CHD2/KDM5B/MPHOSPH8/PBRM1/NCOR1/JARID2/NR3C1/CHD4/RSF1/CHD8/MTF2/HMGA1/DNMT3A/CHD6/SUPT6H/BAZ2B/SETD5/BAZ2A/HMGN3/GATA3/HNRNPC/HNRNPU/HMG20B 38 GO:0006942 regulation of striated muscle contraction 14/969 95/18722 0.000367185050909371 0.00654917773396714 AKAP9/CAV1/DSP/GSTO1/DLG1/DSG2/DSC2/PDE4B/SLC9A1/DMD/CALM1/GJA5/CALM2/SRI 14 GO:1901888 regulation of cell junction assembly 23/969 204/18722 0.000379448072991257 0.00674488309337521 LRP1/CAV1/APP/ACTG1/MACF1/IQGAP1/DLG5/GJA1/S100A10/ROCK1/NRP1/PPP1R9A/PTPRA/EIF4G1/SLC9A1/RHOA/MMP14/VCL/SETD5/CLSTN1/SLK/TPBG/RAB17 23 GO:0006417 regulation of translation 42/969 468/18722 0.000381370146836811 0.00674977265892939 GAPDH/RPL26/APP/ZFP36L1/RPL13A/RPS4X/RPL10/PRKDC/PKM/RPL22/RPS3/SOX4/PPP1R15A/HSPB1/ROCK1/NPM1/PUM1/EIF3H/TNRC6B/TPR/YBX1/NEMF/IGF2BP3/PURA/TNRC6A/EIF4G1/RHOA/CELF1/TIA1/EIF1/PUM2/LARP1/DDX39B/EIF5A/AGO2/EIF2AK4/ATXN2/BTG2/QKI/PABPC1/EIF4H/EIF4B 42 GO:0007568 aging 33/969 339/18722 0.000382306296793551 0.00674977265892939 JUN/FOS/ATP2B1/LRP1/JUND/APP/MIF/DAG1/PRKDC/COL4A2/CDK6/GPX4/CTSC/NPM1/PPP1R9A/YBX1/TBX3/RPN2/CTSV/PAWR/HMGA1/DNMT3A/MAPK14/NEK6/BAZ2B/MME/CITED2/TFCP2L1/GCLM/CDK1/KRAS/CACYBP/TIMP2 33 GO:0072006 nephron development 18/969 142/18722 0.000393197812699951 0.0069148027765234 LAMA5/PBX1/IQGAP1/ENPEP/LGR4/EGR1/DLG1/MAGED1/GLI3/AHI1/IRX2/JAG1/BMP7/CFLAR/TACSTD2/GATA3/CD24/HES1 18 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 10/969 54/18722 0.000394299890433214 0.0069148027765234 JUN/FOS/EGR1/TEAD1/NR3C1/NFIB/YY1/REST/GATA3/KLF5 10 GO:0001656 metanephros development 13/969 85/18722 0.000407808409492406 0.00712778176591075 FBN1/DLG5/LGR4/FRAS1/EGR1/NIPBL/GLI3/NF1/IRX2/AKR1B1/BMP7/GATA3/HES1 13 GO:0042254 ribosome biogenesis 30/969 299/18722 0.000418067827835289 0.00728274156089074 RPLP0/RPS21/RPL14/RPL6/RPS6/RPL23A/RPL24/RPS25/RPL26/RPS8/RPL3/RPL10A/RPS16/RPL7A/RPL11/RPL10/PRKDC/RPL27/RPL7/RPS5/DDX17/RPL35/RPSA/NPM1/RAN/XPO1/SNU13/EBNA1BP2/NHP2/NOP10 30 GO:0006606 protein import into nucleus 19/969 155/18722 0.000421645218709014 0.00732065751818375 CDH1/PPP1R10/RANBP2/TPR/RAN/GLI3/FERMT1/PIK3R1/FAM53C/TNPO1/UBR5/KPNB1/MAPK14/NFKBIA/KPNA6/CDK1/PTTG1IP/KPNA2/SEC13 19 GO:0000723 telomere maintenance 17/969 131/18722 0.000428398941173725 0.0073940994703558 ATRX/PRKDC/PPP1R10/RIF1/PARP1/MAP3K4/PTGES3/RAD50/HNRNPA1/SMG1/HNRNPC/HNRNPU/NHP2/CCT8/NOP10/CCNE1/TPRKB 17 GO:0009314 response to radiation 41/969 456/18722 0.000428704963551054 0.0073940994703558 JUN/EGFR/FOS/JUND/RPL26/APP/HSPA5/ITGB1/RHOB/PRKDC/ANXA1/DDB1/DUSP1/EGR1/NPM1/LRP5/DYNLRB1/GPX1/PARP1/NIPBL/MAP3K4/USP47/GNAQ/NF1/XRRA1/PIK3R1/TXN/YY1/DNMT3A/NMT1/MAPK14/EP300/EIF2AK4/ADIRF/MME/NR2F6/XPC/EEF1D/GATA3/KRAS/UBE2A 41 GO:0097191 extrinsic apoptotic signaling pathway 24/969 219/18722 0.000435495243017413 0.00747520138172724 KRT8/CAV1/KRT18/ITGA6/ITGAV/GSTP1/NRP1/GPX1/PHIP/BIRC6/PMAIP1/HSPA1A/RB1CC1/PIK3R1/MCL1/TCF7L2/LGALS3/PDIA3/CFLAR/SIAH2/GCLM/HSPA1B/HMOX1/NDUFA13 24 GO:0008016 regulation of heart contraction 23/969 206/18722 0.000436267971953082 0.00747520138172724 AKAP9/ATP2B1/CAV1/CYP2J2/DSP/GSTO1/GJA1/GAA/ISL1/DLG1/DSG2/ADRB1/ATP2B4/EPAS1/DSC2/PDE4B/SLC9A1/DMD/CALM1/GJA5/YWHAE/CALM2/SRI 23 GO:0043627 response to estrogen 12/969 75/18722 0.000441903174944472 0.00752242994221437 KRT19/LDHA/CAV1/SERPINB9/GLI3/MMP14/EP300/CITED2/TRIM24/GATA3/CD24/HMOX1 12 GO:0061333 renal tubule morphogenesis 12/969 75/18722 0.000441903174944472 0.00752242994221437 LAMA5/LGR5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/TACSTD2/GATA3/HES1 12 GO:0006479 protein methylation 21/969 181/18722 0.00045674128718642 0.00769752416510274 ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/BTG1/SETD2/NSD1/JARID2/RAB6A/PAXBP1/MTF2/RTF1/SUPT6H/SETD5/BTG2/GATA3/IWS1/LCMT1/PRMT1 21 GO:0008213 protein alkylation 21/969 181/18722 0.00045674128718642 0.00769752416510274 ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/BTG1/SETD2/NSD1/JARID2/RAB6A/PAXBP1/MTF2/RTF1/SUPT6H/SETD5/BTG2/GATA3/IWS1/LCMT1/PRMT1 21 GO:0045786 negative regulation of cell cycle 36/969 385/18722 0.000457016032175843 0.00769752416510274 EGFR/RPL26/ZFP36L1/RHOB/ATRX/PRKDC/SOX4/NR2F2/PPP1R10/CDK6/DUSP1/DLG1/NPM1/TPR/BTG1/USP47/CTDSPL/BRD7/LATS2/TAOK3/FOXN3/TAOK1/DDX39B/WAC/BMP7/MAPK14/EIF2AK4/BTG2/XPC/CDK1/GATA3/LCMT1/HPGD/TIMP2/CCNB1/PTTG1 36 GO:0048864 stem cell development 13/969 86/18722 0.000458080753032329 0.00769752416510274 NRP2/SEMA6A/LAMA5/SEMA6D/ISL1/NRP1/SETD2/MSI2/JAG1/BMP7/CITED2/PDCD6/HES1 13 GO:0030218 erythrocyte differentiation 16/969 120/18722 0.000461128366960247 0.00772390014658414 RPS6/ZFP36L1/PRKDC/TGFBR3/CDK6/UFL1/HSPA1A/EPAS1/RCOR1/SMAD5/ADAR/MAPK14/CITED2/HSPA1B/GATA3/PRMT1 16 GO:0030198 extracellular matrix organization 30/969 301/18722 0.000467489920708406 0.00778058065484754 COL14A1/LRP1/ADAMTSL4/ADAMTS6/CAV1/LAMB1/LAMC1/CCDC80/APP/DAG1/ITGB1/FBLN1/ADAMTS1/SPINT1/COL4A2/ANXA2/VWA1/NF1/FERMT1/SMOC1/CTSV/ADAMTS19/MMP14/LTBP3/MMP15/ELF3/CFLAR/SERPINH1/DPP4/CAV2 30 GO:0042063 gliogenesis 30/969 301/18722 0.000467489920708406 0.00778058065484754 EGFR/LRP2/LRP1/ITGB4/LAMB1/APP/DAG1/ADGRG1/GRN/SPINT1/SOX4/ANXA1/PLEC/CDK6/IL6ST/GSTP1/UFL1/GLI3/NF1/DICER1/S100A9/RHOA/MMP14/NFIB/GPC1/B4GALT5/RTN4/CDK1/KRAS/HES1 30 GO:0043062 extracellular structure organization 30/969 302/18722 0.000494081861274901 0.0081970533556274 COL14A1/LRP1/ADAMTSL4/ADAMTS6/CAV1/LAMB1/LAMC1/CCDC80/APP/DAG1/ITGB1/FBLN1/ADAMTS1/SPINT1/COL4A2/ANXA2/VWA1/NF1/FERMT1/SMOC1/CTSV/ADAMTS19/MMP14/LTBP3/MMP15/ELF3/CFLAR/SERPINH1/DPP4/CAV2 30 GO:0030705 cytoskeleton-dependent intracellular transport 22/969 195/18722 0.000498861164288051 0.00822475028973169 SYNE2/ARMCX3/APP/DYNC1H1/DST/HSPB1/TUBA1C/ARHGAP21/TUBA1B/KIF5B/HOOK2/PURA/PCM1/RAB6A/CCDC186/ACTN4/HOOK3/FLOT2/CDC42/SFPQ/HNRNPU/UXT 22 GO:0072028 nephron morphogenesis 12/969 76/18722 0.000500472750121446 0.00822475028973169 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/BMP7/TACSTD2/GATA3/HES1 12 GO:0086001 cardiac muscle cell action potential 12/969 76/18722 0.000500472750121446 0.00822475028973169 AKAP9/CAV1/DSP/GJA1/ANK3/DLG1/DSG2/DSC2/DMD/CALM1/GJA5/YWHAE 12 GO:0003206 cardiac chamber morphogenesis 16/969 121/18722 0.000506404772412555 0.00829209099325257 LRP2/NRP2/DSP/ADAMTS1/SOX4/TGFBR3/ISL1/NRP1/LY6E/TBX3/JAG1/BMP7/RBPJ/CITED2/GATA3/HES1 16 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 14/969 98/18722 0.000507743803643479 0.00829209099325257 TPT1/MIF/ENO1/HSPB1/PPIA/GPX1/USP47/HSPA1A/MCL1/XBP1/PTTG1IP/NDUFA13/VDAC2/TAF9 14 GO:0044766 multi-organism transport 6/969 21/18722 0.000524956743357668 0.00849357257209651 CAV1/CTSL/KPNA6/CAV2/DYNLT1/KPNA2 6 GO:1902307 positive regulation of sodium ion transmembrane transport 6/969 21/18722 0.000524956743357668 0.00849357257209651 ANK3/KIF5B/SLC9A1/DMD/WNK1/ACTN4 6 GO:1902579 multi-organism localization 6/969 21/18722 0.000524956743357668 0.00849357257209651 CAV1/CTSL/KPNA6/CAV2/DYNLT1/KPNA2 6 GO:0045229 external encapsulating structure organization 30/969 304/18722 0.000551297034547928 0.00886485631553068 COL14A1/LRP1/ADAMTSL4/ADAMTS6/CAV1/LAMB1/LAMC1/CCDC80/APP/DAG1/ITGB1/FBLN1/ADAMTS1/SPINT1/COL4A2/ANXA2/VWA1/NF1/FERMT1/SMOC1/CTSV/ADAMTS19/MMP14/LTBP3/MMP15/ELF3/CFLAR/SERPINH1/DPP4/CAV2 30 GO:0090287 regulation of cellular response to growth factor stimulus 30/969 304/18722 0.000551297034547928 0.00886485631553068 PEG10/FBN1/FBN2/LRP2/CAV1/SEMA6A/HSPA5/CRIM1/GLG1/TGFBR3/CD63/LTBP1/ZNF451/HSPA1A/FERMT1/ATP2B4/TRIM33/LATS2/EP300/GPC1/NREP/RBPJ/CFLAR/HTRA1/CITED2/EPN2/PDCD6/GATA3/CAV2/HES1 30 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 7/969 29/18722 0.000557196854798079 0.00893224160483056 HSPB1/PPIA/GPX1/PARP1/MCL1/P4HB/SFPQ 7 GO:0007492 endoderm development 12/969 77/18722 0.00056543931615187 0.00900910325063924 LAMB1/ITGAV/LAMC1/BPTF/ZFP36L1/COL4A2/DUSP1/SETD2/MMP14/MMP15/RTF1/ITGB5 12 GO:0021675 nerve development 12/969 77/18722 0.00056543931615187 0.00900910325063924 NRP2/RPL24/DAG1/ISL1/NRP1/GLI3/DICER1/CTSV/TFAP2A/CITED2/AFG3L2/HES1 12 GO:0031396 regulation of protein ubiquitination 23/969 210/18722 0.000572602401156992 0.00909550197096182 CAV1/HSPA5/RPS2/MYCBP2/RPL11/RPS20/RPS3/SOX4/NPM1/TRIM44/PPIA/UFL1/SKP1/HSPA1A/HUWE1/UBR5/SIAH2/UBE2C/UBE2L3/PDCD6/HSPA1B/PTTG1IP/CDC20 23 GO:0010232 vascular transport 13/969 88/18722 0.000574505723931922 0.00909808155535825 LRP2/LRP1/SLC2A1/GJA1/SLC38A1/SLC38A2/TFRC/ATP2B4/SLC5A3/SLC16A12/SLC1A5/SLC19A1/SLC13A3 13 GO:0006936 muscle contraction 33/969 347/18722 0.00057763762927263 0.00912004305310806 ALDOA/AKAP9/ATP2B1/CAV1/UTRN/DSP/GSTO1/GJA1/ENO1/GAA/DLG1/ROCK1/MYL6/DSG2/PABPN1/TBX3/ATP2B4/DSC2/PDE4B/SLC9A1/RHOA/ASPH/SMAD5/DMD/CALM1/SSPN/GJA5/HOMER1/MYOF/CALD1/TPM4/CALM2/SRI 33 GO:0097242 amyloid-beta clearance 8/969 38/18722 0.000610729697948731 0.00961347410084357 LRP2/LRP1/ROCK1/CLTC/IGF1R/RAB11A/LRPAP1/MME 8 GO:1900024 regulation of substrate adhesion-dependent cell spreading 10/969 57/18722 0.00061837269200611 0.00970455161688868 FBLN1/KANK1/S100A10/NRP1/TRIOBP/ACTN4/P4HB/RREB1/CDC42/TACSTD2 10 GO:0060840 artery development 14/969 100/18722 0.000624939689281211 0.00977824795264553 LRP2/LRP1/ADAMTS6/SOX4/NRP1/HECTD1/GLI3/NF1/JAG1/GJA5/RBPJ/CITED2/HES1/HPGD 14 GO:0043542 endothelial cell migration 28/969 279/18722 0.000638392499669959 0.00995892299485136 NRP2/ITGB1/MET/RHOB/GRN/EPHB4/ANXA1/NR2F2/S100P/HSPB1/PLPP3/MIA3/NRP1/TMSB4X/GPX1/NF1/ATP2B4/CSNK2B/RHOA/AMOT/FOXP1/DPP4/PDCD6/EMC10/ID1/GATA3/HMOX1/ANXA3 28 GO:1900407 regulation of cellular response to oxidative stress 13/969 89/18722 0.000641510819013346 0.00997778434572544 MET/HSPB1/PPIA/GPX1/PARP1/FUT8/MCL1/TXN/PAWR/BMP7/P4HB/REST/SFPQ 13 GO:0090257 regulation of muscle system process 26/969 252/18722 0.000649929904466813 0.010078734957696 AKAP9/ATP2B1/CAV1/DAG1/DSP/GSTO1/ENO1/IL6ST/DLG1/ROCK1/DSG2/PARP1/ATP2B4/DSC2/PDE4B/SLC9A1/RHOA/JARID2/DMD/CALM1/DDX39B/YY1/GJA5/CAMK2G/CALM2/SRI 26 GO:0010812 negative regulation of cell-substrate adhesion 11/969 68/18722 0.000687832869233313 0.0106349543627612 LRP1/FBLN1/KANK1/RASA1/GCNT2/PIK3R1/RHOA/JAG1/MMP14/ACTN4/TACSTD2 11 GO:0045070 positive regulation of viral genome replication 7/969 30/18722 0.000694643000898405 0.0106457604771116 DDB1/PPIA/PKN2/HACD3/LARP1/ADAR/PABPC1 7 GO:1902751 positive regulation of cell cycle G2/M phase transition 7/969 30/18722 0.000694643000898405 0.0106457604771116 APP/PBX1/BRD4/NPM1/RAB11A/CDK1/CCNB1 7 GO:2000637 positive regulation of gene silencing by miRNA 7/969 30/18722 0.000694643000898405 0.0106457604771116 EGFR/DDX5/PUM1/TNRC6B/EIF4G1/PUM2/AGO2 7 GO:0045216 cell-cell junction organization 22/969 200/18722 0.000704328269500866 0.0107626302234255 CAV1/SVEP1/CDH1/ACTG1/DSP/DLG5/GJA1/CTNND1/PLEC/DLG1/ROCK1/DSG2/PKN2/JAM3/CLDN4/TLN1/RHOA/VCL/GJA5/CDC42/RHOC/CLDN7 22 GO:2000736 regulation of stem cell differentiation 10/969 58/18722 0.000713095355225442 0.010785554980249 N4BP2L2/PRKDC/JAG1/LTBP3/CDK12/REST/TACSTD2/LBH/HES1/HNRNPU 10 GO:0033599 regulation of mammary gland epithelial cell proliferation 5/969 15/18722 0.000714083816143542 0.010785554980249 GPX1/KDM5B/RREB1/RTN4/GATA3 5 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 5/969 15/18722 0.000714083816143542 0.010785554980249 TNRC6B/TNRC6A/AGO2/BTG2/PABPC1 5 GO:1901660 calcium ion export 5/969 15/18722 0.000714083816143542 0.010785554980249 ATP2B1/ATP2B4/CALM1/YWHAE/CALM2 5 GO:0060420 regulation of heart growth 12/969 79/18722 0.000716755642349733 0.0107947117778666 GJA1/TGFBR3/DUSP6/JARID2/DDX39B/YY1/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 12 GO:0060048 cardiac muscle contraction 17/969 137/18722 0.000721411950600826 0.0108336173960917 AKAP9/CAV1/DSP/GSTO1/GJA1/GAA/DLG1/DSG2/DSC2/PDE4B/SLC9A1/SMAD5/DMD/CALM1/GJA5/CALM2/SRI 17 GO:0022900 electron transport chain 20/969 175/18722 0.00074825081145228 0.0112044663055863 PLEC/DHRS2/GLDC/COX6A1/CYP19A1/UQCRH/COX8C/ASPH/COX5A/AKR1B1/UQCRQ/COX7B/CDK1/ETFA/DNAJC15/GHITM/NDUFA13/NDUFA6/CCNB1/SDHC 20 GO:0048193 Golgi vesicle transport 29/969 296/18722 0.000759127349653873 0.0113348557979747 GOLGA4/KRT18/MACF1/LMAN1/TRIP11/CUX1/PLPP3/ANK3/MIA3/GCC2/VPS13C/PGAP1/EXOC1/SPTBN1/SEC31A/COPA/VPS13A/RAB6A/CREB3L2/TRAPPC1/UVRAG/PDCD6/VAMP2/GOPC/COPB1/VAMP3/ARF4/KDELR2/SEC13 29 GO:0031060 regulation of histone methylation 11/969 69/18722 0.000780688311504239 0.0116235815268409 ATRX/BRD4/RIF1/NSD1/JARID2/PAXBP1/MTF2/RTF1/SUPT6H/GATA3/IWS1 11 GO:0072080 nephron tubule development 13/969 91/18722 0.000795412321638755 0.0118091613434208 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/JAG1/TACSTD2/GATA3/CD24/HES1 13 GO:0010634 positive regulation of epithelial cell migration 20/969 176/18722 0.000804140708430442 0.011904927315177 NRP2/PFN1/MET/RHOB/GRN/ANXA1/HSPB1/PLPP3/NRP1/TMSB4X/RAB11A/FOXP1/RREB1/RTN4/PDCD6/EMC10/GATA3/HMOX1/ANXA3/RAB25 20 GO:0070849 response to epidermal growth factor 9/969 49/18722 0.000812731832901973 0.011964328334495 EEF1A1/EGFR/ZFP36L1/IQGAP1/GSTP1/TPR/PTPN12/CFLAR/ID1 9 GO:0072091 regulation of stem cell proliferation 9/969 49/18722 0.000812731832901973 0.011964328334495 ZFP36L1/N4BP2L2/FBLN1/GJA1/TBX3/FERMT1/LTBP3/HNRNPU/CCNE1 9 GO:0090303 positive regulation of wound healing 10/969 59/18722 0.00081945503448717 0.0119988419868321 ITGB1/ACTG1/KANK1/ANXA1/PLPP3/CLDN4/FERMT1/XBP1/RREB1/ARFGEF1 10 GO:0034976 response to endoplasmic reticulum stress 26/969 256/18722 0.000821964299901625 0.0119988419868321 JUN/CAV1/HSP90B1/HSPA5/PPP1R15A/UFL1/PMAIP1/HSPA1A/SEL1L/EIF4G1/PIK3R1/DNAJB14/CREB3L2/CCDC47/MBTPS1/PDIA3/FAF2/EP300/EIF2AK4/XBP1/P4HB/TMEM259/DDIT3/UBXN4/UFC1/CASP4 26 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 26/969 256/18722 0.000821964299901625 0.0119988419868321 PEG10/FBN1/FBN2/LRP2/LRP1/CAV1/HSPA5/CRIM1/GLG1/TGFBR3/LTBP1/PARP1/ZNF451/HSPA1A/FERMT1/CSNK2B/TRIM33/LATS2/BMP7/EP300/NREP/RBPJ/HTRA1/CITED2/CAV2/HES1 26 GO:0060148 positive regulation of posttranscriptional gene silencing 7/969 31/18722 0.000857608452051226 0.0124842946251245 EGFR/DDX5/PUM1/TNRC6B/EIF4G1/PUM2/AGO2 7 GO:0034968 histone lysine methylation 15/969 115/18722 0.000865154344149837 0.0125393916100906 ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/SETD2/NSD1/JARID2/MTF2/RTF1/SUPT6H/SETD5/GATA3/IWS1 15 GO:0030048 actin filament-based movement 16/969 127/18722 0.000866192187379009 0.0125393916100906 AKAP9/SYNE2/CAV1/MYH10/DSP/GJA1/WASF2/DLG1/MYL6/DSG2/DSC2/PDE4B/SLC9A1/ACTN4/GJA5/SRI 16 GO:0043001 Golgi to plasma membrane protein transport 8/969 40/18722 0.000876339127991546 0.0126512383505078 GOLGA4/KRT18/MACF1/ANK3/SPTBN1/VAMP2/GOPC/VAMP3 8 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 12/969 81/18722 0.000900544285433633 0.0129648607043421 PEG10/FBN1/FBN2/CAV1/HSPA5/GLG1/TGFBR3/LTBP1/ZNF451/HSPA1A/HTRA1/CAV2 12 GO:0030177 positive regulation of Wnt signaling pathway 17/969 140/18722 0.000923228440185896 0.0132549226055261 EGFR/CAV1/RPS12/KANK1/LGR5/MACF1/WLS/SOX4/LGR4/USP34/USP47/TBL1X/UBR5/WNK1/RBPJ/USP8/ATP6AP2 17 GO:0048872 homeostasis of number of cells 27/969 272/18722 0.000933113448456391 0.0133601394017345 RPS6/ZFP36L1/ADGRG1/PRKDC/SOX4/ANXA1/LGR4/TGFBR3/PRDX1/CDK6/UFL1/JAM3/PMAIP1/HSPA1A/EPAS1/RCOR1/PDE4B/SMAD5/ADAR/MAPK14/ZFX/CITED2/HSPA1B/GATA3/KRAS/HMOX1/PRMT1 27 GO:0021782 glial cell development 15/969 116/18722 0.000947156334790058 0.0134872997428143 EGFR/LRP1/ITGB4/APP/DAG1/GRN/SOX4/PLEC/CDK6/GSTP1/NF1/DICER1/S100A9/B4GALT5/KRAS 15 GO:0030518 intracellular steroid hormone receptor signaling pathway 15/969 116/18722 0.000947156334790058 0.0134872997428143 DDX5/DDX17/ISL1/UFL1/PARP1/PTGES3/ARID1A/RHOA/NCOR1/NR3C1/UBR5/FOXP1/EP300/TMF1/LBH 15 GO:0045927 positive regulation of growth 26/969 259/18722 0.00097580334374671 0.0138304065596014 EGFR/LRP1/GOLGA4/MACF1/IGF2/PRKDC/TGFBR3/NRP1/NIPBL/USP47/S100A9/RAB11A/EIF4G1/CSH1/SLC9A1/RHOA/CELF1/MMP14/DDX39B/MAPK14/RBPJ/TFCP2L1/CDC42/CDK1/EZR/CCNB1 26 GO:1901796 regulation of signal transduction by p53 class mediator 13/969 93/18722 0.00097919066725077 0.0138304065596014 RPL26/MIF/RPL11/RPS20/DDX5/NPM1/PMAIP1/EIF5A/EP300/TRIM24/PTTG1IP/TAF9/AURKA 13 GO:1901992 positive regulation of mitotic cell cycle phase transition 13/969 93/18722 0.00097919066725077 0.0138304065596014 EGFR/APP/PBX1/ADAMTS1/BRD4/ANXA1/RAB11A/EIF4G1/ANAPC11/ANKRD17/UBE2C/CDK1/CCNB1 13 GO:0006402 mRNA catabolic process 24/969 232/18722 0.000992430652110701 0.0138307785742702 FUS/ZFP36L1/DDX5/ROCK1/NPM1/PUM1/TNRC6B/HSPA1A/YBX1/TNRC6A/UPF2/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HNRNPC/HNRNPU/SSB 24 GO:0001732 formation of cytoplasmic translation initiation complex 5/969 16/18722 0.000994662581490454 0.0138307785742702 EIF3A/EIF2S2/EIF3H/EIF3I/EIF3F 5 GO:0017014 protein nitrosylation 5/969 16/18722 0.000994662581490454 0.0138307785742702 GAPDH/S100A9/ATP2B4/TXN/DMD 5 GO:0018119 peptidyl-cysteine S-nitrosylation 5/969 16/18722 0.000994662581490454 0.0138307785742702 GAPDH/S100A9/ATP2B4/TXN/DMD 5 GO:0019081 viral translation 5/969 16/18722 0.000994662581490454 0.0138307785742702 EIF3A/EIF2AK4/PCBP2/EIF3F/SSB 5 GO:0072078 nephron tubule morphogenesis 11/969 71/18722 0.000997717529248564 0.0138307785742702 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/TACSTD2/GATA3/HES1 11 GO:0016571 histone methylation 17/969 141/18722 0.00100038926541793 0.0138307785742702 ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/SETD2/NSD1/JARID2/PAXBP1/MTF2/RTF1/SUPT6H/SETD5/GATA3/IWS1/PRMT1 17 GO:0032355 response to estradiol 17/969 141/18722 0.00100038926541793 0.0138307785742702 EGFR/GJA1/ANXA1/NR2F2/GPX4/DUSP1/NCOA3/GSTP1/CYP19A1/NRIP1/ESRRA/DNMT3A/BMP7/SLC6A4/MMP15/CFLAR/HPGD 17 GO:2001020 regulation of response to DNA damage stimulus 23/969 219/18722 0.0010214371698928 0.0140499848493675 TPT1/EGFR/FUS/RPL26/MIF/PRKDC/DDX5/RPS3/PPP1R10/NPM1/RIF1/PARP1/BCLAF1/PMAIP1/USP47/SETD2/MCL1/SMG1/UBR5/DDX39B/IER3/PTTG1IP/TAF9 23 GO:0048638 regulation of developmental growth 31/969 330/18722 0.00102162155429768 0.0140499848493675 LRP1/GOLGA4/SEMA6A/APP/MACF1/IGF2/PRKDC/SEMA6D/GJA1/TGFBR3/DUSP6/NRP1/ADRB1/NIPBL/RAB11A/LATS2/CELF1/JARID2/DDX39B/YY1/MAPK14/SLC6A4/RBPJ/VGLL4/CITED2/RTN4/SPAG9/AFG3L2/CDK1/EZR/CCNB1 31 GO:0016052 carbohydrate catabolic process 18/969 154/18722 0.00103799173345061 0.014229035567797 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/AGL/GAA/LRP5/MANBA/RB1CC1/FUT8/NCOR1/EP300/PYGL/PGAM1/PGK1 18 GO:0042307 positive regulation of protein import into nucleus 8/969 41/18722 0.00104008641157643 0.014229035567797 CDH1/TPR/RAN/GLI3/PIK3R1/UBR5/MAPK14/CDK1 8 GO:0010644 cell communication by electrical coupling 7/969 32/18722 0.00104928497869643 0.0142801127569467 CAV1/GJA1/ANK3/CALM1/GJA5/CALM2/SRI 7 GO:0051642 centrosome localization 7/969 32/18722 0.00104928497869643 0.0142801127569467 AKAP9/SYNE2/DLG1/RANBP2/KIF5B/EZR/AURKA 7 GO:0030865 cortical cytoskeleton organization 10/969 61/18722 0.00107137788924271 0.0145429112965777 RHOB/PLEC/DLG1/ROCK1/FMNL2/TLN1/RHOA/RHOBTB3/EZR/RHOC 10 GO:0060043 regulation of cardiac muscle cell proliferation 9/969 51/18722 0.00109718711610509 0.0148546628724487 GJA1/TGFBR3/JARID2/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 9 GO:0050679 positive regulation of epithelial cell proliferation 22/969 207/18722 0.00111302832590613 0.0150301964630114 EGFR/NRP2/LAMB1/LAMC1/GRN/IGF2/NRP1/KDM5B/RICTOR/TCF7L2/XBP1/RREB1/CFLAR/HTRA1/RTN4/CDC42/SRSF6/PDCD6/EMC10/ID1/HMOX1/CAV2 22 GO:0033627 cell adhesion mediated by integrin 11/969 72/18722 0.00112360473493645 0.0150950085984008 FBN1/ITGB4/ITGAV/ITGB1/PLPP3/JAM3/ITGB8/FERMT1/WNK1/ITGB5/DPP4 11 GO:0055021 regulation of cardiac muscle tissue growth 11/969 72/18722 0.00112360473493645 0.0150950085984008 GJA1/TGFBR3/JARID2/DDX39B/YY1/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 11 GO:0033002 muscle cell proliferation 25/969 248/18722 0.00114026497202001 0.0152795506250682 JUN/EGFR/SF1/ADAMTS1/PRKDC/GJA1/TGFBR3/GSTP1/RHOA/JARID2/GNA12/FOXP1/TCF7L2/AKR1B1/DDX39B/PAXBP1/MAPK14/RBPJ/VGLL4/CFLAR/CITED2/CDK1/HMOX1/HPGD/CCNB1 25 GO:0030953 astral microtubule organization 4/969 10/18722 0.00116492433665324 0.015530343324872 DLG1/RAB11A/KPNB1/EZR 4 GO:0036363 transforming growth factor beta activation 4/969 10/18722 0.00116492433665324 0.015530343324872 ITGAV/LTBP1/ITGB8/LTBP3 4 GO:0045930 negative regulation of mitotic cell cycle 24/969 235/18722 0.00118578215102607 0.0157681870770032 EGFR/RPL26/ZFP36L1/PRKDC/SOX4/PPP1R10/DUSP1/DLG1/TPR/BTG1/USP47/CTDSPL/BRD7/TAOK3/FOXN3/TAOK1/WAC/BMP7/BTG2/XPC/CDK1/LCMT1/TIMP2/CCNB1 24 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 16/969 131/18722 0.00121129320636852 0.0160665438997003 PEG10/FBN1/FBN2/LRP2/LRP1/CAV1/HSPA5/CRIM1/GLG1/TGFBR3/LTBP1/ZNF451/HSPA1A/TRIM33/HTRA1/CAV2 16 GO:0046824 positive regulation of nucleocytoplasmic transport 10/969 62/18722 0.00121923174160187 0.0160901643475035 CDH1/TPR/RAN/GLI3/PIK3R1/UBR5/TCF7L2/MAPK14/CDK1/YWHAE 10 GO:0060135 maternal process involved in female pregnancy 10/969 62/18722 0.00121923174160187 0.0160901643475035 GJA1/NR2F2/ASH1L/JUNB/CTSV/AKR1B1/CITED2/KPNA6/STC2/UBE2A 10 GO:0072088 nephron epithelium morphogenesis 11/969 73/18722 0.00126228686232395 0.0165331106328446 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/TACSTD2/GATA3/HES1 11 GO:0072089 stem cell proliferation 11/969 73/18722 0.00126228686232395 0.0165331106328446 ZFP36L1/N4BP2L2/FBLN1/RNF43/GJA1/ZNRF3/TBX3/FERMT1/LTBP3/HNRNPU/CCNE1 11 GO:0086003 cardiac muscle cell contraction 11/969 73/18722 0.00126228686232395 0.0165331106328446 AKAP9/CAV1/DSP/GJA1/DLG1/DSG2/DSC2/PDE4B/SLC9A1/GJA5/SRI 11 GO:0048048 embryonic eye morphogenesis 7/969 33/18722 0.0012730519599281 0.0165496754790652 FBN1/FBN2/EFEMP1/TFAP2A/BMP7/CITED2/MFAP5 7 GO:0061842 microtubule organizing center localization 7/969 33/18722 0.0012730519599281 0.0165496754790652 AKAP9/SYNE2/DLG1/RANBP2/KIF5B/EZR/AURKA 7 GO:0071353 cellular response to interleukin-4 7/969 33/18722 0.0012730519599281 0.0165496754790652 RPLP0/HSPA5/RPL3/TUBA1B/XBP1/GATA3/IMPDH2 7 GO:0001763 morphogenesis of a branching structure 21/969 196/18722 0.00128900889374988 0.0166972220405902 DAG1/LAMA5/MET/PBX1/DLG5/SPINT1/LGR4/RERE/DLG1/MAGED1/LRP5/NRP1/SETD2/GLI3/TBX3/KDM5B/MMP14/BMP7/RTN4/TACSTD2/KRAS 21 GO:0022898 regulation of transmembrane transporter activity 27/969 278/18722 0.00129079175361623 0.0166972220405902 TCAF1/AHNAK/AKAP9/CAV1/APP/C4orf3/ITGB1/UTRN/GSTO1/GJA1/ANK3/DLG1/TMSB4X/KIF5B/PDE4B/SLC9A1/DMD/CALM1/WNK1/AHCYL1/ACTN4/HOMER1/VAMP2/GOPC/YWHAE/CALM2/SRI 27 GO:0030178 negative regulation of Wnt signaling pathway 19/969 170/18722 0.00130943874763892 0.0168966096176815 LRP1/CAV1/TLE4/RNF43/CTNND1/ISL1/EGR1/ZNRF3/GLI3/FERMT1/RNF213/LATS2/TCF7L2/CHD8/MAPK14/VGLL4/DDIT3/SIAH2/TPBG 19 GO:0045667 regulation of osteoblast differentiation 16/969 132/18722 0.00131374314265215 0.016910398185961 FBN2/JUND/CRIM1/DDX5/CDK6/IL6ST/LRP5/SUCO/GLI3/SMOC1/SMAD5/CLIC1/JAG1/ESRRA/BMP7/REST 16 GO:0010769 regulation of cell morphogenesis involved in differentiation 13/969 96/18722 0.00132055034435027 0.0169562557729104 FBLN1/KANK1/PRKDC/CUX1/S100A10/NRP1/TRIOBP/ACTN4/P4HB/RREB1/CDC42/OBSL1/TACSTD2 13 GO:0051897 positive regulation of protein kinase B signaling 15/969 120/18722 0.00134397081373579 0.0172146849818216 EGFR/LRP2/ITGB1/MET/IGF2/IGF1R/GPX1/GCNT2/RICTOR/TXN/TCF7L2/RTN4/ARFGEF1/GATA3/TPBG 15 GO:0043488 regulation of mRNA stability 18/969 158/18722 0.00139492822645919 0.0178237039400385 FUS/ZFP36L1/ROCK1/NPM1/PUM1/TNRC6B/YBX1/TNRC6A/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HNRNPC/HNRNPU 18 GO:0048844 artery morphogenesis 11/969 74/18722 0.00141472710776007 0.017967811556074 LRP2/LRP1/SOX4/NRP1/NF1/JAG1/GJA5/RBPJ/CITED2/HES1/HPGD 11 GO:1903201 regulation of oxidative stress-induced cell death 11/969 74/18722 0.00141472710776007 0.017967811556074 MET/HSPB1/PPIA/GPX1/PARP1/MCL1/TXN/PAWR/P4HB/REST/SFPQ 11 GO:0007265 Ras protein signal transduction 31/969 337/18722 0.00143119710917723 0.017967811556074 JUN/ITGB1/MET/RHOB/KANK1/ADGRG1/CFL1/RASA1/WASF2/ROCK1/AKAP13/NRP1/EPS8L1/DENND4C/DHCR24/NF1/ARHGAP5/RHOA/ABCA1/HACD3/GNA12/KPNB1/RREB1/ARFGEF1/USP8/CDC42/EPS8/KRAS/DYNLT1/TIMP2/STMN1 31 GO:0031579 membrane raft organization 6/969 25/18722 0.00143474259433945 0.017967811556074 CAV1/S100A10/DLG1/ANXA2/FLOT2/CAV2 6 GO:0033119 negative regulation of RNA splicing 6/969 25/18722 0.00143474259433945 0.017967811556074 RPS13/RPS26/NPM1/SRSF7/SAP18/SRSF6 6 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 6/969 25/18722 0.00143474259433945 0.017967811556074 CAV1/GJA1/CALM1/GJA5/CALM2/SRI 6 GO:1901798 positive regulation of signal transduction by p53 class mediator 6/969 25/18722 0.00143474259433945 0.017967811556074 RPL26/RPL11/RPS20/DDX5/PMAIP1/EIF5A 6 GO:0014002 astrocyte development 8/969 43/18722 0.00144058802946709 0.017967811556074 EGFR/LRP1/APP/GRN/CDK6/NF1/S100A9/KRAS 8 GO:0071604 transforming growth factor beta production 8/969 43/18722 0.00144058802946709 0.017967811556074 CD46/ITGAV/LTBP1/ITGB8/FERMT1/LTBP3/ATP6AP2/CD24 8 GO:1904591 positive regulation of protein import 8/969 43/18722 0.00144058802946709 0.017967811556074 CDH1/TPR/RAN/GLI3/PIK3R1/UBR5/MAPK14/CDK1 8 GO:0010001 glial cell differentiation 23/969 225/18722 0.00146695179247681 0.0182530715892471 EGFR/LRP1/ITGB4/APP/DAG1/GRN/SPINT1/SOX4/PLEC/CDK6/IL6ST/GSTP1/GLI3/NF1/DICER1/S100A9/RHOA/NFIB/GPC1/B4GALT5/CDK1/KRAS/HES1 23 GO:0072009 nephron epithelium development 14/969 109/18722 0.00147589193739907 0.0183206918404929 LAMA5/PBX1/IQGAP1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/JAG1/TACSTD2/GATA3/CD24/HES1 14 GO:0032412 regulation of ion transmembrane transporter activity 26/969 267/18722 0.00151389198116934 0.0187478660985568 TCAF1/AHNAK/AKAP9/CAV1/APP/C4orf3/ITGB1/UTRN/GSTO1/ANK3/DLG1/TMSB4X/KIF5B/PDE4B/SLC9A1/DMD/CALM1/WNK1/AHCYL1/ACTN4/HOMER1/VAMP2/GOPC/YWHAE/CALM2/SRI 26 GO:0007431 salivary gland development 7/969 34/18722 0.00153246712416155 0.018933033548152 DAG1/LAMA5/NRP1/NFIB/BMP7/TFCP2L1/CDC42 7 GO:0001508 action potential 16/969 134/18722 0.00154066474754241 0.0189894197421147 AKAP9/CAV1/DSP/GJA1/ANK3/DLG1/DSG2/GNAQ/DSC2/SLC9A1/DMD/CALM1/USP53/GJA5/YWHAE/SRI 16 GO:0032409 regulation of transporter activity 29/969 310/18722 0.00155628067421324 0.0191367595375022 TCAF1/AHNAK/AKAP9/CAV1/APP/C4orf3/ITGB1/UTRN/GSTO1/GJA1/ANK3/DLG1/TMSB4X/KIF5B/SLC5A3/PDE4B/SLC9A1/DMD/CALM1/WNK1/AHCYL1/ACTN4/HOMER1/RXRA/VAMP2/GOPC/YWHAE/CALM2/SRI 29 GO:0071692 protein localization to extracellular region 33/969 368/18722 0.00156247357946928 0.0191678096861654 FBN1/FBN2/EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANXA1/ISL1/MIA3/LTBP1/LRP5/PPIA/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/SYT7/SEL1L/EXPH5/ABCA1/GNPTAB/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/EZR/SRI 33 GO:0071478 cellular response to radiation 20/969 186/18722 0.00159120963182787 0.0194746171801696 RPL26/HSPA5/RHOB/DDB1/EGR1/NPM1/PARP1/NIPBL/USP47/PIK3R1/YY1/NMT1/MAPK14/EP300/EIF2AK4/ADIRF/MME/XPC/EEF1D/GATA3 20 GO:1902882 regulation of response to oxidative stress 13/969 98/18722 0.0015990300674809 0.019524605450129 MET/HSPB1/PPIA/GPX1/PARP1/FUT8/MCL1/TXN/PAWR/BMP7/P4HB/REST/SFPQ 13 GO:0035637 multicellular organismal signaling 18/969 160/18722 0.00160929960164535 0.0195970485700605 AKAP9/ATP2B1/CAV1/DSP/GJA1/PLEC/ANK3/ISL1/DSG2/JAM3/ATP2B4/DSC2/SLC9A1/CALM1/GJA5/YWHAE/CALM2/SRI 18 GO:0007088 regulation of mitotic nuclear division 14/969 110/18722 0.00161246285593686 0.0195970485700605 IGF2/DUSP1/LRP5/PHIP/TPR/ANAPC11/BMP7/CDC42/OBSL1/CAV2/LCMT1/NUSAP1/CCNB1/AURKA 14 GO:0001706 endoderm formation 9/969 54/18722 0.00166977103219868 0.0202464580377502 LAMB1/ITGAV/COL4A2/DUSP1/SETD2/MMP14/MMP15/RTF1/ITGB5 9 GO:0021762 substantia nigra development 8/969 44/18722 0.00168214148426278 0.0203022434105249 DYNLL1/HSPA5/RHOA/CALM1/CDC42/YWHAE/CALM2/YWHAQ 8 GO:0030521 androgen receptor signaling pathway 8/969 44/18722 0.00168214148426278 0.0203022434105249 DDX5/DDX17/ARID1A/RHOA/NCOR1/FOXP1/EP300/TMF1 8 GO:0033044 regulation of chromosome organization 20/969 187/18722 0.00169745654380411 0.0203918228040306 ATRX/PPP1R10/DUSP1/PARP1/MAP3K4/TPR/RAD50/HNRNPA1/MPHOSPH8/ANAPC11/SMG1/NEK6/UBE2C/SFPQ/HNRNPC/HNRNPU/LCMT1/CCT8/CCNB1/PTTG1 20 GO:0150104 transport across blood-brain barrier 12/969 87/18722 0.00170126956420921 0.0203918228040306 LRP2/LRP1/SLC2A1/SLC38A1/SLC38A2/TFRC/ATP2B4/SLC5A3/SLC16A12/SLC1A5/SLC19A1/SLC13A3 12 GO:1900182 positive regulation of protein localization to nucleus 12/969 87/18722 0.00170126956420921 0.0203918228040306 CDH1/NPM1/PARP1/TPR/RAN/GLI3/TFRC/PIK3R1/UBR5/MAPK14/CDK1/CCT8 12 GO:0001731 formation of translation preinitiation complex 4/969 11/18722 0.00175590583893315 0.0207610043309155 RPL13A/EIF2S2/EIF4H/EIF4B 4 GO:0034975 protein folding in endoplasmic reticulum 4/969 11/18722 0.00175590583893315 0.0207610043309155 HSP90B1/HSPA5/PDIA3/P4HB 4 GO:0035581 sequestering of extracellular ligand from receptor 4/969 11/18722 0.00175590583893315 0.0207610043309155 FBN1/FBN2/CD46/LTBP1 4 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 4/969 11/18722 0.00175590583893315 0.0207610043309155 GSTO1/CALM1/CALM2/SRI 4 GO:0075522 IRES-dependent viral translational initiation 4/969 11/18722 0.00175590583893315 0.0207610043309155 EIF3A/PCBP2/EIF3F/SSB 4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 4/969 11/18722 0.00175590583893315 0.0207610043309155 CAV1/CALM1/CALM2/SRI 4 GO:0014855 striated muscle cell proliferation 11/969 76/18722 0.00176494727016666 0.0208208000765033 GJA1/TGFBR3/JARID2/PAXBP1/MAPK14/RBPJ/VGLL4/CFLAR/CITED2/CDK1/CCNB1 11 GO:1903522 regulation of blood circulation 25/969 256/18722 0.00177557236349844 0.0208989666027992 EGFR/AKAP9/ATP2B1/CAV1/CYP2J2/DSP/GSTO1/GJA1/GAA/ISL1/DLG1/DSG2/ADRB1/ATP2B4/EPAS1/DSC2/PDE4B/SLC9A1/RHOA/DMD/CALM1/GJA5/YWHAE/CALM2/SRI 25 GO:0046697 decidualization 6/969 26/18722 0.00178445935516809 0.0209563698654122 GJA1/ASH1L/JUNB/CTSV/CITED2/STC2 6 GO:0072073 kidney epithelium development 16/969 136/18722 0.00179964510360147 0.0210873213260567 LAMA5/PBX1/IQGAP1/LGR4/DLG1/MAGED1/GLI3/AHI1/IRX2/SMAD5/JAG1/BMP7/TACSTD2/GATA3/CD24/HES1 16 GO:0001893 maternal placenta development 7/969 35/18722 0.00183125582134095 0.0213143494929349 GJA1/NR2F2/ASH1L/JUNB/CTSV/CITED2/STC2 7 GO:0010765 positive regulation of sodium ion transport 7/969 35/18722 0.00183125582134095 0.0213143494929349 ANK3/KIF5B/SLC9A1/DMD/WNK1/AHCYL1/ACTN4 7 GO:0035633 maintenance of blood-brain barrier 7/969 35/18722 0.00183125582134095 0.0213143494929349 LAMC1/ITGB1/ACTG1/GJA1/JAM3/DMD/VCL 7 GO:0038066 p38MAPK cascade 9/969 55/18722 0.00190648671726479 0.0220915733579286 ZFP36L1/GADD45B/DUSP1/DLG1/MAP3K4/MAPK14/EMC10/EZR/PRMT1 9 GO:0098900 regulation of action potential 9/969 55/18722 0.00190648671726479 0.0220915733579286 AKAP9/CAV1/DSP/DLG1/DSG2/DSC2/SLC9A1/CALM1/GJA5 9 GO:0009612 response to mechanical stimulus 22/969 216/18722 0.00192545623524102 0.0222620227552424 JUN/EGFR/FOS/JUND/FOSB/DAG1/SLC2A1/GJA1/PLEC/SLC38A2/TMEM150C/SLC9A1/RHOA/MMP14/DMD/MAPK14/USP53/CITED2/NFKBIA/BTG2/XPC/CCNB1 22 GO:0006986 response to unfolded protein 16/969 137/18722 0.00194222138829576 0.0224062891285511 HSPA5/PPP1R15A/HSPB1/UFL1/HSPA1A/PIK3R1/DNAJB1/CREB3L2/MBTPS1/FAF2/EP300/XBP1/SERPINH1/DDIT3/UBXN4/HSPA1B 16 GO:0035987 endodermal cell differentiation 8/969 45/18722 0.00195461482705813 0.0224501474422106 LAMB1/ITGAV/COL4A2/SETD2/MMP14/MMP15/RTF1/ITGB5 8 GO:0071364 cellular response to epidermal growth factor stimulus 8/969 45/18722 0.00195461482705813 0.0224501474422106 EEF1A1/EGFR/ZFP36L1/IQGAP1/GSTP1/PTPN12/CFLAR/ID1 8 GO:0071900 regulation of protein serine/threonine kinase activity 32/969 359/18722 0.00200768545144208 0.0230091319500796 EGFR/CAV1/CCNL1/IQGAP1/IGF2/RPS3/NR2F2/DUSP1/AKAP13/MAGED1/GSTP1/LRP5/MAP3K4/NF1/ATP2B4/RICTOR/RHOA/LATS2/TAOK3/TAOK1/CALM1/CDK12/SERTAD1/BMP7/CKS1B/UVRAG/KRAS/CD24/CALM2/CDKN3/CCNB1/CCNE1 32 GO:0030324 lung development 19/969 177/18722 0.00209709425829231 0.0239812135532508 EGFR/DAG1/LAMA5/DLG5/PTGES3/GLI3/EPAS1/MAN2A1/MMP14/NFIB/LTBP3/MAN1A2/EP300/RBPJ/MME/CDC42/SRSF6/KRAS/HES1 19 GO:0048754 branching morphogenesis of an epithelial tube 17/969 151/18722 0.00212333413453372 0.0242282624171904 DAG1/LAMA5/MET/PBX1/DLG5/LGR4/DLG1/MAGED1/LRP5/NRP1/GLI3/TBX3/KDM5B/MMP14/BMP7/TACSTD2/KRAS 17 GO:0007059 chromosome segregation 31/969 346/18722 0.00216160060517671 0.0245836803221778 DYNC1H1/ATRX/RPS3/DUSP1/PUM1/NIPBL/TPR/RAN/USP9X/RAB11A/ANAPC11/PDS5A/EML4/NR3C1/PUM2/KPNB1/NEK6/UBE2C/STAG1/CDC42/UVRAG/BANF1/SFPQ/HNRNPU/LCMT1/CENPN/NUSAP1/CDC20/CCNB1/PTTG1/CCNE1 31 GO:0043388 positive regulation of DNA binding 9/969 56/18722 0.00216924857708409 0.0245836803221778 ISL1/PARP1/TXN/CALM1/EP300/EDF1/GATA3/CALM2/HES1 9 GO:0051385 response to mineralocorticoid 7/969 36/18722 0.00217329894926256 0.0245836803221778 FOS/ATP2B1/FOSB/RPL27/PARP1/CALM1/KRAS 7 GO:0070670 response to interleukin-4 7/969 36/18722 0.00217329894926256 0.0245836803221778 RPLP0/HSPA5/RPL3/TUBA1B/XBP1/GATA3/IMPDH2 7 GO:0070997 neuron death 32/969 361/18722 0.00219116514957771 0.0246471339936328 GAPDH/JUN/FOS/LRP1/APP/HSPA5/GRN/RASA1/ISL1/EGR1/NRP1/GPX1/PARP1/DHCR24/NF1/EIF4G1/SLC9A1/RHOA/MCL1/TFAP2A/SIAH1/USP53/TMEM259/BTG2/DDIT3/CDC42/REST/GCLM/GATA3/KRAS/HMOX1/PSMC1 32 GO:2001235 positive regulation of apoptotic signaling pathway 15/969 126/18722 0.00219451819862553 0.0246471339936328 CAV1/RPL26/RPL11/RPS3/CTSC/MAGED1/BCLAF1/PMAIP1/S100A9/MCL1/EIF5A/SIAH1/PDIA3/DDIT3/SFPQ 15 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 6/969 27/18722 0.0021951397918139 0.0246471339936328 APP/PBX1/BRD4/RAB11A/CDK1/CCNB1 6 GO:0051402 neuron apoptotic process 24/969 246/18722 0.00219777352488191 0.0246471339936328 GAPDH/JUN/LRP1/APP/HSPA5/GRN/RASA1/ISL1/NRP1/GPX1/PARP1/NF1/RHOA/MCL1/TFAP2A/SIAH1/USP53/BTG2/DDIT3/CDC42/GCLM/GATA3/KRAS/HMOX1 24 GO:0002244 hematopoietic progenitor cell differentiation 14/969 114/18722 0.00226835866943194 0.0253842449816945 PRRC2C/RBM47/N4BP2L2/PRKDC/SOX4/UFL1/JAM3/CHD2/ZFAT/ADAR/CITED2/REST/GATA3/HES1 14 GO:0030901 midbrain development 12/969 90/18722 0.00228084439189232 0.025415123223943 DYNLL1/HSPA5/WLS/DLG5/RHOA/CALM1/UQCRQ/CDC42/YWHAE/CALM2/HES1/YWHAQ 12 GO:0046031 ADP metabolic process 12/969 90/18722 0.00228084439189232 0.025415123223943 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/PGAM1/PGK1/AK2 12 GO:0061564 axon development 39/969 467/18722 0.00228852070298559 0.0254464025400057 NRP2/LRP1/GOLGA4/RPL24/SEMA6A/APP/DAG1/LAMA5/ITGB1/MYCBP2/GRN/MACF1/SEMA6D/EPHB4/ANK3/ISL1/NRP1/PTPRF/JAM3/KIF5B/MTR/USP9X/GLI3/RAB11A/RPS6KA5/CAMSAP2/PLXNB1/NFIB/VCL/SIAH1/BMP7/B4GALT5/NREP/B3GNT2/RTN4/AFG3L2/GATA3/DYNLT1/STMN1 39 GO:0006491 N-glycan processing 5/969 19/18722 0.0023262447970613 0.0257562612488185 GANAB/FUT8/MAN2A1/GNPTAB/MAN1A2 5 GO:0045947 negative regulation of translational initiation 5/969 19/18722 0.0023262447970613 0.0257562612488185 RPL13A/TPR/LARP1/AGO2/EIF2AK4 5 GO:0006941 striated muscle contraction 19/969 179/18722 0.00238455539402884 0.0263460602308556 ALDOA/AKAP9/CAV1/DSP/GSTO1/GJA1/GAA/DLG1/DSG2/DSC2/PDE4B/SLC9A1/SMAD5/DMD/CALM1/GJA5/HOMER1/CALM2/SRI 19 GO:0007548 sex differentiation 26/969 276/18722 0.00240749851480265 0.0265434329923178 LRP2/HSPA5/SF1/PBX1/ADGRG1/ATRX/ADAMTS1/NR2F2/LGR4/EIF2S2/CYP19A1/NIPBL/KDM5A/DHCR24/TBX3/NRIP1/SMAD5/CTSV/MMP14/ZFX/RHOBTB3/ARID5B/IDH1/CITED2/TMF1/GATA3 26 GO:0061013 regulation of mRNA catabolic process 18/969 166/18722 0.00242638259494629 0.0266953167182932 FUS/ZFP36L1/ROCK1/NPM1/PUM1/TNRC6B/YBX1/TNRC6A/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HNRNPC/HNRNPU 18 GO:0006354 DNA-templated transcription, elongation 12/969 91/18722 0.00250647964307007 0.0271687098988806 BRD4/ARID1A/SETD2/TCERG1/ZNF326/DDX39B/CDK12/SERTAD1/RTF1/SUPT6H/SETD5/HNRNPU 12 GO:0055006 cardiac cell development 12/969 91/18722 0.00250647964307007 0.0271687098988806 PLEC/TGFBR3/ISL1/AKAP13/TBX3/JAG1/DDX39B/YY1/OBSL1/CDK1/HNRNPU/CCNB1 12 GO:0002027 regulation of heart rate 13/969 103/18722 0.00251344326459122 0.0271687098988806 AKAP9/CAV1/DSP/ISL1/DSG2/ADRB1/EPAS1/DSC2/DMD/CALM1/YWHAE/CALM2/SRI 13 GO:0009135 purine nucleoside diphosphate metabolic process 13/969 103/18722 0.00251344326459122 0.0271687098988806 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/DLG1/NCOR1/EP300/PGAM1/PGK1/AK2 13 GO:0009179 purine ribonucleoside diphosphate metabolic process 13/969 103/18722 0.00251344326459122 0.0271687098988806 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/DLG1/NCOR1/EP300/PGAM1/PGK1/AK2 13 GO:0046831 regulation of RNA export from nucleus 4/969 12/18722 0.00252659644294986 0.0271687098988806 TPR/SETD2/SUPT6H/IWS1 4 GO:0061307 cardiac neural crest cell differentiation involved in heart development 4/969 12/18722 0.00252659644294986 0.0271687098988806 JAG1/BMP7/CITED2/HES1 4 GO:0061308 cardiac neural crest cell development involved in heart development 4/969 12/18722 0.00252659644294986 0.0271687098988806 JAG1/BMP7/CITED2/HES1 4 GO:0070493 thrombin-activated receptor signaling pathway 4/969 12/18722 0.00252659644294986 0.0271687098988806 IQGAP2/MET/HPGD/STMN1 4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 4/969 12/18722 0.00252659644294986 0.0271687098988806 JUN/HSPA1A/DNAJB1/CITED2 4 GO:1990034 calcium ion export across plasma membrane 4/969 12/18722 0.00252659644294986 0.0271687098988806 ATP2B1/CALM1/YWHAE/CALM2 4 GO:0010721 negative regulation of cell development 19/969 180/18722 0.00254026248415843 0.0272595723659384 FBN1/SEMA6A/FBLN1/KANK1/SEMA6D/NRP1/NF1/DICER1/PCM1/PRTG/BMP7/ACTN4/RTN4/HOOK3/REST/TACSTD2/ID1/HES1/DYNLT1 19 GO:0003018 vascular process in circulatory system 25/969 263/18722 0.00255962959170866 0.0273311231939967 EGFR/LRP2/ATP2B1/LRP1/CAV1/SLC2A1/GJA1/PLEC/SLC38A1/ROCK1/GPX1/ADRB1/SLC38A2/TFRC/ATP2B4/SLC5A3/SLC16A12/RHOA/SLC1A5/SOD3/SLC6A4/GJA5/GCLM/SLC19A1/SLC13A3 25 GO:0043588 skin development 25/969 263/18722 0.00255962959170866 0.0273311231939967 EGFR/ITGB4/ITGA6/LAMA5/ZFP36L1/MET/DSP/LGR5/ANXA1/LGR4/PLEC/ASH1L/FRAS1/ROCK1/NCOA3/PTGES3/CLDN4/DHCR24/FERMT1/EXPH5/JAG1/RBPJ/SRSF6/STMN1/KRT10 25 GO:0003161 cardiac conduction system development 7/969 37/18722 0.00256261966419027 0.0273311231939967 GJA1/ISL1/DSG2/TBX3/SMAD5/GJA5/CDC42 7 GO:0010632 regulation of epithelial cell migration 27/969 292/18722 0.00261275567232887 0.0278090858321602 NRP2/PFN1/MET/RHOB/GRN/MACF1/ANXA1/NR2F2/HSPB1/PLPP3/NRP1/TMSB4X/NF1/ATP2B4/RAB11A/CSNK2B/RHOA/FOXP1/RREB1/RTN4/PDCD6/EMC10/TACSTD2/GATA3/HMOX1/ANXA3/RAB25 27 GO:0006401 RNA catabolic process 26/969 278/18722 0.00265795413504918 0.0282326591661932 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/PUM1/TNRC6B/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HNRNPC/HNRNPU/SSB 26 GO:0000470 maturation of LSU-rRNA 6/969 28/18722 0.00267319422681183 0.028325641216032 RPL10A/RPL7A/RPL7/RPL35/SNU13/NHP2 6 GO:0001570 vasculogenesis 11/969 80/18722 0.00267754817464979 0.028325641216032 CAV1/ITGAV/ZFP36L1/RASA1/TGFBR3/SETD2/ITGB8/AMOT/JUNB/CITED2/QKI 11 GO:0045936 negative regulation of phosphate metabolic process 37/969 441/18722 0.00270404085128117 0.0284944099014826 LRP1/CAV1/DYNLL1/BOD1L1/FBLN1/GADD45B/PRKDC/NR2F2/PLEC/PPP1R15A/DUSP6/HSPB1/PLPP3/DUSP1/ROCK1/NPM1/GSTP1/LRP5/PPIA/PARP1/GNAQ/NF1/CTDSPL/EIF4G1/NCOR1/LATS2/LGALS3/DMD/CALM1/ADAR/BMP7/WNK1/SPAG9/YWHAE/CALM2/HNRNPU/CCNB1 37 GO:0030323 respiratory tube development 19/969 181/18722 0.00270440629757661 0.0284944099014826 EGFR/DAG1/LAMA5/DLG5/PTGES3/GLI3/EPAS1/MAN2A1/MMP14/NFIB/LTBP3/MAN1A2/EP300/RBPJ/MME/CDC42/SRSF6/KRAS/HES1 19 GO:0048762 mesenchymal cell differentiation 23/969 236/18722 0.00272161182715647 0.0286179947861563 NRP2/SEMA6A/DAG1/LAMA5/DLG5/DDX5/SEMA6D/TGFBR3/DDX17/ISL1/ROCK1/NRP1/TBX3/GCNT2/JAG1/TCF7L2/BMP7/RBPJ/CITED2/RTN4/PDCD6/GATA3/HES1 23 GO:0060419 heart growth 13/969 104/18722 0.00273978745749786 0.0286851712112842 GJA1/TGFBR3/DUSP6/AKAP13/JARID2/DDX39B/YY1/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 13 GO:0031058 positive regulation of histone modification 12/969 92/18722 0.00274995613793597 0.0286851712112842 BRD4/ISL1/RIF1/NIPBL/BRD7/RPS6KA5/JARID2/PAXBP1/MTF2/RTF1/GATA3/CCNB1 12 GO:0032465 regulation of cytokinesis 12/969 92/18722 0.00274995613793597 0.0286851712112842 PKN2/BIRC6/SETD2/RAB11A/RHOA/PRPF40A/SVIL/CALM1/CDC42/UVRAG/CALM2/AURKA 12 GO:1903312 negative regulation of mRNA metabolic process 12/969 92/18722 0.00274995613793597 0.0286851712112842 FUS/NPM1/SRSF7/YBX1/SAP18/LARP1/MAPK14/THRAP3/SRSF6/PABPC1/HNRNPC/HNRNPU 12 GO:0000070 mitotic sister chromatid segregation 18/969 168/18722 0.00276611829969196 0.0287390342628036 ATRX/DUSP1/NIPBL/TPR/RAN/RAB11A/ANAPC11/PDS5A/EML4/KPNB1/NEK6/UBE2C/HNRNPU/LCMT1/NUSAP1/CDC20/CCNB1/PTTG1 18 GO:0016482 cytosolic transport 18/969 168/18722 0.00276611829969196 0.0287390342628036 EEA1/CLTC/GCC2/VPS13C/ERC1/KIF5B/HOOK2/SYT7/TMEM87A/VPS13A/RAB6A/RHOBTB3/EVI5/HOOK3/SPAG9/EZR/VAMP3/VPS29 18 GO:0086065 cell communication involved in cardiac conduction 9/969 58/18722 0.00278090478620553 0.0288144606223325 CAV1/DSP/GJA1/DSG2/DSC2/CALM1/GJA5/CALM2/SRI 9 GO:0045669 positive regulation of osteoblast differentiation 10/969 69/18722 0.00278440539882853 0.0288144606223325 FBN2/JUND/IL6ST/LRP5/SUCO/GLI3/SMAD5/CLIC1/JAG1/BMP7 10 GO:0010563 negative regulation of phosphorus metabolic process 37/969 442/18722 0.00280889813268745 0.0290104775522226 LRP1/CAV1/DYNLL1/BOD1L1/FBLN1/GADD45B/PRKDC/NR2F2/PLEC/PPP1R15A/DUSP6/HSPB1/PLPP3/DUSP1/ROCK1/NPM1/GSTP1/LRP5/PPIA/PARP1/GNAQ/NF1/CTDSPL/EIF4G1/NCOR1/LATS2/LGALS3/DMD/CALM1/ADAR/BMP7/WNK1/SPAG9/YWHAE/CALM2/HNRNPU/CCNB1 37 GO:1902905 positive regulation of supramolecular fiber organization 21/969 209/18722 0.0028373360760693 0.0292463872456374 AKAP9/APP/PFN1/IQGAP2/CLIP1/MET/RPS3/S100A10/WASF2/ARPC3/DLG1/NRP1/GPX1/HSPA1A/SCIN/RICTOR/RHOA/CDC42/HSPA1B/ID1/RHOC 21 GO:0051225 spindle assembly 14/969 117/18722 0.00289316980287391 0.029763199586258 DYNC1H1/RPS3/TPR/HSPA1A/RAB11A/RHOA/NCOR1/KPNB1/NEK6/STAG1/HSPA1B/HNRNPU/CDC20/AURKA 14 GO:0021543 pallium development 18/969 169/18722 0.00295033024702517 0.0301482892581393 LRP1/LAMB1/ADGRG1/SLC2A1/CDK6/TRA2B/TACC2/SLC38A2/KIF5B/GLI3/NF1/ATP2B4/RHOA/CELF1/RTN4/UQCRQ/BTG2/ANXA3 18 GO:0006096 glycolytic process 11/969 81/18722 0.00295679164295519 0.0301482892581393 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/PGAM1/PGK1 11 GO:0014032 neural crest cell development 11/969 81/18722 0.00295679164295519 0.0301482892581393 NRP2/SEMA6A/LAMA5/SEMA6D/ISL1/NRP1/JAG1/BMP7/CITED2/PDCD6/HES1 11 GO:0003159 morphogenesis of an endothelium 5/969 20/18722 0.00297098525984342 0.0301482892581393 RHOB/CSNK2B/RHOA/FOXP1/RBPJ 5 GO:0007097 nuclear migration 5/969 20/18722 0.00297098525984342 0.0301482892581393 SYNE2/DYNC1H1/PCM1/HOOK3/CDC42 5 GO:0061154 endothelial tube morphogenesis 5/969 20/18722 0.00297098525984342 0.0301482892581393 RHOB/CSNK2B/RHOA/FOXP1/RBPJ 5 GO:0097150 neuronal stem cell population maintenance 5/969 20/18722 0.00297098525984342 0.0301482892581393 PCM1/JAG1/HOOK3/REST/HES1 5 GO:0040029 regulation of gene expression, epigenetic 13/969 105/18722 0.00298251648904063 0.0302066495576092 IGF2/GPX1/TPR/ARID1A/MPHOSPH8/CREBZF/DNMT3A/SERTAD1/EP300/YTHDC1/BAZ2A/CDYL/HNRNPU 13 GO:0006470 protein dephosphorylation 26/969 281/18722 0.00307499006803367 0.0310829750397369 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/DUSP6/DUSP1/DLG1/ROCK1/PTPN14/PPIA/PHPT1/PTPRF/CTDSPL/PTPRA/CSNK2B/PPP1R12A/PPP6R2/PTPN12/LGALS3/CALM1/PTPRE/SPPL3/CAMK2G/YWHAE/CALM2/CDKN3 26 GO:0022612 gland morphogenesis 14/969 118/18722 0.00313038768651896 0.0315210135833297 CAV1/DAG1/LAMA5/LRP5/NRP1/GLI3/TBX3/KDM5B/NFIB/BMP7/XBP1/ELF3/CFLAR/CDC42 14 GO:1903313 positive regulation of mRNA metabolic process 14/969 118/18722 0.00313038768651896 0.0315210135833297 ZFP36L1/PRDX6/TRA2B/ROCK1/PUM1/TNRC6B/TNRC6A/CELF1/AGO2/BTG2/THRAP3/PABPC1/TRA2A/CCNB1 14 GO:0043487 regulation of RNA stability 18/969 170/18722 0.00314464634563669 0.0315436473561673 FUS/ZFP36L1/ROCK1/NPM1/PUM1/TNRC6B/YBX1/TNRC6A/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HNRNPC/HNRNPU 18 GO:0010975 regulation of neuron projection development 37/969 445/18722 0.00314470728522066 0.0315436473561673 LRP1/GOLGA4/ITGA6/TENM3/SEMA6A/HSPA5/KANK1/GRN/MACF1/IQGAP1/CFL1/SEMA6D/CUX1/NRP1/KIDINS220/PTPRF/PPP1R9A/S100A9/RAB11A/RHOA/THOC2/CAMSAP2/PLXNB1/CREB3L2/BMP7/EP300/SETX/CFLAR/RTN4/MYLIP/OBSL1/CAMK2G/ID1/GATA3/RAB17/DYNLT1/CDC20 37 GO:0009743 response to carbohydrate 24/969 253/18722 0.00316684188184138 0.0317048192998143 LDHA/LRP1/KRT18/DYNLL1/ZFP36L1/GJA1/SOX4/TRA2B/EGR1/GSTP1/LRP5/IGF1R/PHPT1/KIF5B/RHOA/CTSV/CCDC186/TCF7L2/COLEC12/XBP1/HMGN3/GCLM/VAMP2/SRI 24 GO:0043491 protein kinase B signaling 21/969 211/18722 0.00317757311194525 0.0317514284570284 EGFR/LRP2/DAG1/ZFP36L1/ITGB1/MET/IGF2/DLG1/IGF1R/GPX1/GCNT2/RICTOR/TXN/TCF7L2/SETX/RTN4/ARFGEF1/DDIT3/PDCD6/GATA3/TPBG 21 GO:0034284 response to monosaccharide 22/969 225/18722 0.00319521411074336 0.0318667727914977 LDHA/LRP1/KRT18/DYNLL1/GJA1/SOX4/TRA2B/EGR1/GSTP1/LRP5/IGF1R/PHPT1/KIF5B/RHOA/CTSV/CCDC186/TCF7L2/XBP1/HMGN3/GCLM/VAMP2/SRI 22 GO:0018022 peptidyl-lysine methylation 15/969 131/18722 0.0032077782854556 0.0318704359691844 ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/SETD2/NSD1/JARID2/MTF2/RTF1/SUPT6H/SETD5/GATA3/IWS1 15 GO:0019079 viral genome replication 15/969 131/18722 0.0032077782854556 0.0318704359691844 DDX5/DDB1/EEA1/PPIA/PKN2/MPHOSPH8/HACD3/LARP1/ADAR/EIF2AK4/PCBP2/CDC42/PABPC1/KPNA6/BANF1 15 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 6/969 29/18722 0.0032251935412502 0.0319826592914109 RPL26/MIF/RPL11/EIF5A/PTTG1IP/TAF9 6 GO:0009185 ribonucleoside diphosphate metabolic process 13/969 106/18722 0.00324249273328613 0.0320933087578662 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/DLG1/NCOR1/EP300/PGAM1/PGK1/AK2 13 GO:0006757 ATP generation from ADP 11/969 82/18722 0.00325899301661479 0.0321956474571435 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/PGAM1/PGK1 11 GO:0019080 viral gene expression 12/969 94/18722 0.00329453433991347 0.0324241741250241 JUN/EIF3A/FUT8/MAN2A1/RSF1/EP300/EIF2AK4/PCBP2/EIF3F/REST/GALNT1/SSB 12 GO:1902414 protein localization to cell junction 12/969 94/18722 0.00329453433991347 0.0324241741250241 DAG1/ACTG1/DSP/DLG5/HSPB1/DLG1/JAM3/KIF5B/RAB11A/VCL/CLSTN1/VAMP2 12 GO:0009410 response to xenobiotic stimulus 38/969 462/18722 0.00334796596813105 0.0328881017846858 JUN/EGFR/FOS/LDHA/CDH1/CYP2J2/FOSB/HSPA5/GSTO1/ANXA1/PLIN2/DUSP6/S100A10/GSTP1/GPX1/USP47/TFRC/PDE4B/RPN2/RHOA/ABCA1/GNA12/PPP1R12A/DNMT3A/SLC6A4/ADIRF/XPO1/REST/GCLM/XPC/HADHA/CDK1/GATA3/HMOX1/GGH/TIMP2/CCNB1/GSTA3 38 GO:0071241 cellular response to inorganic substance 22/969 226/18722 0.00337205308968819 0.0330625693184062 JUN/EGFR/FOS/CDH1/FUS/JUND/FOSB/APP/HSPA5/ATRX/IQGAP1/ANK3/PARP1/MTR/SYT7/JUNB/TFAP2A/WNK1/CFLAR/HMOX1/CACYBP/CCNB1 22 GO:0006376 mRNA splice site selection 8/969 49/18722 0.00340854926274421 0.0333578248073057 SF1/SRSF5/LUC7L3/CELF1/SETX/YTHDC1/SRSF6/SNRPC 8 GO:0007369 gastrulation 19/969 185/18722 0.00345249198035872 0.0335818090659618 ITGB4/RPS6/LAMB1/ITGAV/DAG1/ITGB1/WLS/COL4A2/GJA1/DUSP1/LRP5/SETD2/AMOT/MMP14/BMP7/WNK1/MMP15/RTF1/ITGB5 19 GO:0051896 regulation of protein kinase B signaling 19/969 185/18722 0.00345249198035872 0.0335818090659618 EGFR/LRP2/DAG1/ITGB1/MET/IGF2/DLG1/IGF1R/GPX1/GCNT2/RICTOR/TXN/TCF7L2/RTN4/ARFGEF1/DDIT3/PDCD6/GATA3/TPBG 19 GO:0086091 regulation of heart rate by cardiac conduction 7/969 39/18722 0.00349981061483625 0.0335818090659618 AKAP9/CAV1/DSP/ISL1/DSG2/DSC2/YWHAE 7 GO:0016246 RNA interference 4/969 13/18722 0.00350118434733443 0.0335818090659618 DICER1/CELF1/ADAR/AGO2 4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 4/969 13/18722 0.00350118434733443 0.0335818090659618 BRD4/TCERG1/CDK12/SUPT6H 4 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 4/969 13/18722 0.00350118434733443 0.0335818090659618 GSTO1/CALM1/CALM2/SRI 4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 4/969 13/18722 0.00350118434733443 0.0335818090659618 TMSB4X/NSD1/EP300/DDIT3 4 GO:0005976 polysaccharide metabolic process 13/969 107/18722 0.00352060234968669 0.0335818090659618 IGF2/AGL/IL6ST/GAA/CLTC/PTGES3/PHKB/RB1CC1/SORBS1/B4GALT5/UGP2/B3GNT2/PYGL 13 GO:0010927 cellular component assembly involved in morphogenesis 13/969 107/18722 0.00352060234968669 0.0335818090659618 KRT19/KRT8/ITGB4/DAG1/ITGB1/ACTG1/PLEC/AKAP13/DICER1/GPC1/CFLAR/TMF1/OBSL1 13 GO:0031532 actin cytoskeleton reorganization 13/969 107/18722 0.00352060234968669 0.0335818090659618 IQGAP2/ANXA1/PLEC/NRP1/PHPT1/NRK/RICTOR/THSD7A/GAB1/RHOA/CDC42/EPS8/EZR 13 GO:0006893 Golgi to plasma membrane transport 9/969 60/18722 0.00352139903715023 0.0335818090659618 GOLGA4/KRT18/MACF1/ANK3/EXOC1/SPTBN1/VAMP2/GOPC/VAMP3 9 GO:0042306 regulation of protein import into nucleus 9/969 60/18722 0.00352139903715023 0.0335818090659618 CDH1/TPR/RAN/GLI3/FERMT1/PIK3R1/UBR5/MAPK14/CDK1 9 GO:0060038 cardiac muscle cell proliferation 9/969 60/18722 0.00352139903715023 0.0335818090659618 GJA1/TGFBR3/JARID2/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 9 GO:0061951 establishment of protein localization to plasma membrane 9/969 60/18722 0.00352139903715023 0.0335818090659618 GOLGA4/KRT18/MACF1/ANK3/SPTBN1/RAB11A/VAMP2/GOPC/VAMP3 9 GO:0048736 appendage development 18/969 172/18722 0.00356527659700774 0.033876609992659 FBN2/ITGB4/ITGA6/PBX1/ATRX/SOX4/NR2F2/FRAS1/LRP5/NIPBL/ZNRF3/GLI3/TBX3/SMOC1/TFAP2A/MBNL1/BMP7/TMEM107 18 GO:0060173 limb development 18/969 172/18722 0.00356527659700774 0.033876609992659 FBN2/ITGB4/ITGA6/PBX1/ATRX/SOX4/NR2F2/FRAS1/LRP5/NIPBL/ZNRF3/GLI3/TBX3/SMOC1/TFAP2A/MBNL1/BMP7/TMEM107 18 GO:0031397 negative regulation of protein ubiquitination 11/969 83/18722 0.00358547804321679 0.0340067300432866 CAV1/RPL11/RPS20/RPS3/SOX4/TRIM44/PPIA/UFL1/HSPA1A/UBR5/HSPA1B 11 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 12/969 95/18722 0.00359776086368137 0.0340614099159399 CAV1/RPL11/RPS20/RPS3/SOX4/TRIM44/PPIA/UFL1/HSPA1A/UBR5/HSPA1B/HMG20B 12 GO:0010038 response to metal ion 32/969 373/18722 0.00362359623052143 0.0342439672707143 JUN/EGFR/FOS/CAV1/CDH1/FUS/JUND/FOSB/APP/HSPA5/IQGAP1/ANK3/DUSP1/PARP1/SYT7/SEC31A/JUNB/SOD3/TFAP2A/TRPV6/CALM1/DNMT3A/WNK1/AHCYL1/HOMER1/PDCD6/CDK1/HMOX1/GGH/CALM2/CACYBP/CCNB1 32 GO:0032200 telomere organization 17/969 159/18722 0.00365207172916887 0.0343321390634239 ATRX/PRKDC/PPP1R10/RIF1/PARP1/MAP3K4/PTGES3/RAD50/HNRNPA1/SMG1/HNRNPC/HNRNPU/NHP2/CCT8/NOP10/CCNE1/TPRKB 17 GO:0035966 response to topologically incorrect protein 17/969 159/18722 0.00365207172916887 0.0343321390634239 HSPA5/PPP1R15A/HSPB1/UFL1/HSPA1A/PIK3R1/DNAJB1/DNAJB14/CREB3L2/MBTPS1/FAF2/EP300/XBP1/SERPINH1/DDIT3/UBXN4/HSPA1B 17 GO:0048593 camera-type eye morphogenesis 14/969 120/18722 0.00365263477215149 0.0343321390634239 TENM3/LRP5/FAT1/GLI3/NF1/AHI1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1 14 GO:0007043 cell-cell junction assembly 16/969 146/18722 0.00370354771364923 0.0347304070407305 CAV1/ACTG1/DLG5/GJA1/CTNND1/DLG1/ROCK1/PKN2/JAM3/CLDN4/TLN1/RHOA/VCL/GJA5/RHOC/CLDN7 16 GO:0010595 positive regulation of endothelial cell migration 15/969 133/18722 0.0037082983407439 0.0347304070407305 NRP2/MET/RHOB/GRN/ANXA1/HSPB1/PLPP3/NRP1/TMSB4X/FOXP1/PDCD6/EMC10/GATA3/HMOX1/ANXA3 15 GO:0032516 positive regulation of phosphoprotein phosphatase activity 5/969 21/18722 0.00373536917124521 0.0348589987302276 SLC39A10/PPP1R15A/PPP1R12A/CALM1/CALM2 5 GO:0048485 sympathetic nervous system development 5/969 21/18722 0.00373536917124521 0.0348589987302276 NRP2/SOX4/NRP1/NF1/GATA3 5 GO:0005977 glycogen metabolic process 10/969 72/18722 0.00382060335409903 0.0355275322571558 IGF2/AGL/IL6ST/GAA/PTGES3/PHKB/RB1CC1/SORBS1/UGP2/PYGL 10 GO:0030330 DNA damage response, signal transduction by p53 class mediator 10/969 72/18722 0.00382060335409903 0.0355275322571558 RPL26/MIF/ATRX/DDX5/SOX4/NPM1/PMAIP1/USP10/MDM4/PTTG1IP 10 GO:0046825 regulation of protein export from nucleus 6/969 30/18722 0.00385783117633815 0.0356832313761826 PTPN14/TPR/TXN/TCF7L2/XPO1/YWHAE 6 GO:0060674 placenta blood vessel development 6/969 30/18722 0.00385783117633815 0.0356832313761826 SPINT1/NR2F2/ITGB8/JUNB/RBPJ/HES1 6 GO:2000648 positive regulation of stem cell proliferation 6/969 30/18722 0.00385783117633815 0.0356832313761826 N4BP2L2/GJA1/TBX3/LTBP3/HNRNPU/CCNE1 6 GO:0061136 regulation of proteasomal protein catabolic process 19/969 187/18722 0.00388669014205381 0.035886647848716 CAV1/RPL11/EIF3H/GPX1/UFL1/HECTD1/HSPA1A/DDA1/GNA12/WAC/XPO1/TMEM259/PSME2/TMF1/HSPA1B/CDC20/PSMC1/TAF9/AURKA 19 GO:0044264 cellular polysaccharide metabolic process 12/969 96/18722 0.00392307665215723 0.0360469851336177 IGF2/AGL/IL6ST/GAA/PTGES3/PHKB/RB1CC1/SORBS1/B4GALT5/UGP2/B3GNT2/PYGL 12 GO:0055017 cardiac muscle tissue growth 12/969 96/18722 0.00392307665215723 0.0360469851336177 GJA1/TGFBR3/AKAP13/JARID2/DDX39B/YY1/MAPK14/RBPJ/VGLL4/CITED2/CDK1/CCNB1 12 GO:0010921 regulation of phosphatase activity 11/969 84/18722 0.00393760779156008 0.0360469851336177 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/ROCK1/CSNK2B/PPP1R12A/PPP6R2/LGALS3/CALM1/CALM2 11 GO:0001704 formation of primary germ layer 14/969 121/18722 0.00393919520643212 0.0360469851336177 ITGB4/LAMB1/ITGAV/ITGB1/WLS/COL4A2/GJA1/DUSP1/SETD2/MMP14/BMP7/MMP15/RTF1/ITGB5 14 GO:0016049 cell growth 39/969 482/18722 0.00394207374795066 0.0360469851336177 EGFR/NRP2/LRP1/GOLGA4/SEMA6A/APP/ITGB1/MACF1/IQGAP1/SEMA6D/GJA1/ENO1/AKAP13/NPM1/NRP1/BTG1/USP47/HSPA1A/KIAA1109/SMARCA2/USP9X/S100A9/RAB11A/EIF4G1/SLC9A1/RHOA/MMP14/DDX39B/YY1/VCL/EIF2AK4/CLSTN1/VGLL4/RTN4/SPAG9/CDC42/HSPA1B/NDUFA13/AURKA 39 GO:0034113 heterotypic cell-cell adhesion 9/969 61/18722 0.00394544115890343 0.0360469851336177 ITGAV/ITGB1/DSP/DSG2/JAM3/GCNT2/DSC2/BMP7/WNK1 9 GO:0043414 macromolecule methylation 28/969 316/18722 0.00402210584654526 0.0366832899721562 FOS/ZC3H13/ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/PARP1/BTG1/SETD2/MPHOSPH8/NSD1/JARID2/RAB6A/PAXBP1/MTF2/DNMT3A/RTF1/SUPT6H/SETD5/BAZ2A/RNMT/BTG2/GATA3/IWS1/LCMT1/PRMT1 28 GO:0014037 Schwann cell differentiation 7/969 40/18722 0.00405630456659119 0.0367718301998303 ITGB4/DAG1/PLEC/NF1/DICER1/GPC1/CDK1 7 GO:0035329 hippo signaling 7/969 40/18722 0.00405630456659119 0.0367718301998303 DLG5/TEAD1/AMOT/LATS2/MAPK14/AMOTL1/VGLL4 7 GO:0045740 positive regulation of DNA replication 7/969 40/18722 0.00405630456659119 0.0367718301998303 JUN/EGFR/ATRX/CDC42/CDK1/CACYBP/STOML2 7 GO:0003002 regionalization 29/969 331/18722 0.00405995905574093 0.0367718301998303 LRP2/NRP2/BPTF/PBX1/ADGRG1/WLS/PRKDC/NR2F2/TRA2B/ISL1/LRP5/NRP1/PGAP1/GLI3/TBX3/BHLHE41/AHI1/IRX2/MTF2/YY1/EP300/TMEM107/RBPJ/CITED2/BTG2/DDIT3/ATP6AP2/HES1/AURKA 29 GO:0018205 peptidyl-lysine modification 32/969 376/18722 0.00408619217686528 0.0369453984711038 ATRX/BRD4/SOX4/ASH1L/KMT2C/ISL1/EGR1/NCOA3/TET2/RIF1/RANBP2/ZNF451/SETD2/MORF4L2/BRD7/RPS6KA5/NSD1/JARID2/USP22/MTF2/PHF20L1/EP300/RTF1/PHF14/SUPT6H/SETD5/PHF20/EID1/GATA3/IWS1/TAF9/HMG20B 32 GO:0000819 sister chromatid segregation 20/969 202/18722 0.00416777681414503 0.0376179648198997 ATRX/DUSP1/NIPBL/TPR/RAN/RAB11A/ANAPC11/PDS5A/EML4/KPNB1/NEK6/UBE2C/STAG1/SFPQ/HNRNPU/LCMT1/NUSAP1/CDC20/CCNB1/PTTG1 20 GO:0006073 cellular glucan metabolic process 10/969 73/18722 0.00422668533692046 0.0379530198810075 IGF2/AGL/IL6ST/GAA/PTGES3/PHKB/RB1CC1/SORBS1/UGP2/PYGL 10 GO:0042274 ribosomal small subunit biogenesis 10/969 73/18722 0.00422668533692046 0.0379530198810075 RPS21/RPS6/RPS25/RPS8/RPS16/PRKDC/RPS5/RPSA/NPM1/SNU13 10 GO:0044042 glucan metabolic process 10/969 73/18722 0.00422668533692046 0.0379530198810075 IGF2/AGL/IL6ST/GAA/PTGES3/PHKB/RB1CC1/SORBS1/UGP2/PYGL 10 GO:0070252 actin-mediated cell contraction 12/969 97/18722 0.00427161440014498 0.038225097354722 AKAP9/CAV1/DSP/GJA1/DLG1/MYL6/DSG2/DSC2/PDE4B/SLC9A1/GJA5/SRI 12 GO:1901216 positive regulation of neuron death 12/969 97/18722 0.00427161440014498 0.038225097354722 JUN/FOS/GRN/EGR1/PARP1/NF1/RHOA/MCL1/TFAP2A/DDIT3/CDC42/REST 12 GO:0032835 glomerulus development 9/969 62/18722 0.00440838238070937 0.0392473702241689 IQGAP1/ENPEP/LGR4/EGR1/JAG1/BMP7/CFLAR/CD24/HES1 9 GO:0060675 ureteric bud morphogenesis 9/969 62/18722 0.00440838238070937 0.0392473702241689 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/TACSTD2/GATA3/HES1 9 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 9/969 62/18722 0.00440838238070937 0.0392473702241689 DAG1/CTNND1/DLG1/RAB11A/CLSTN1/FLOT2/EPS8/VAMP2/YWHAE 9 GO:0003007 heart morphogenesis 23/969 246/18722 0.00455410619656232 0.0402761364936916 LRP2/NRP2/DSP/ADAMTS1/SOX4/EPHB4/TGFBR3/GAA/ISL1/NRP1/NIPBL/LY6E/TBX3/AHI1/JAG1/BMP7/MDM4/GJA5/RBPJ/CITED2/RTN4/GATA3/HES1 23 GO:0010811 positive regulation of cell-substrate adhesion 14/969 123/18722 0.00456715814631684 0.0402761364936916 ITGA6/CCDC80/DAG1/UTRN/IQGAP1/CDK6/S100A10/ROCK1/NRP1/FERMT1/TRIOBP/P4HB/RREB1/CDC42 14 GO:0045727 positive regulation of translation 15/969 136/18722 0.00457734198759336 0.0402761364936916 RPL26/RPS4X/PRKDC/PKM/SOX4/PPP1R15A/NPM1/EIF4G1/RHOA/LARP1/DDX39B/EIF5A/AGO2/EIF2AK4/PABPC1 15 GO:1900180 regulation of protein localization to nucleus 15/969 136/18722 0.00457734198759336 0.0402761364936916 CDH1/MAGED1/NPM1/PARP1/TPR/RAN/GLI3/FERMT1/TFRC/PIK3R1/LATS2/UBR5/MAPK14/CDK1/CCT8 15 GO:0071711 basement membrane organization 6/969 31/18722 0.00457788463016701 0.0402761364936916 CAV1/LAMB1/DAG1/ITGB1/FERMT1/CAV2 6 GO:0090162 establishment of epithelial cell polarity 6/969 31/18722 0.00457788463016701 0.0402761364936916 FRMD4A/FAT1/FERMT1/RHOA/CDC42/HES1 6 GO:1900027 regulation of ruffle assembly 6/969 31/18722 0.00457788463016701 0.0402761364936916 CAV1/PFN1/KANK1/EPS8L1/EPS8/TACSTD2 6 GO:0050767 regulation of neurogenesis 31/969 364/18722 0.00461457980211718 0.0404364636807068 EGFR/LRP2/LRP1/GOLGA4/SEMA6A/DAG1/MACF1/SPINT1/SEMA6D/CUX1/IL6ST/NRP1/UFL1/GLI3/NF1/DICER1/BHLHE41/PCM1/RAB11A/MAN2A1/PLXNB1/PRTG/BMP7/MME/RTN4/HOOK3/OBSL1/REST/ID1/HES1/DYNLT1 31 GO:0099563 modification of synaptic structure 5/969 22/18722 0.00463093444824269 0.0404364636807068 PFN1/MYH10/RHOA/CDC42/REST 5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 5/969 22/18722 0.00463093444824269 0.0404364636807068 SMAD5/EP300/XBP1/RBPJ/CHD6 5 GO:0007040 lysosome organization 10/969 74/18722 0.00466605381022679 0.0404364636807068 GRN/GAA/HOOK2/SYT7/ABCA1/GNPTAB/MBTPS1/NAGLU/HOOK3/ATP6AP2 10 GO:0080171 lytic vacuole organization 10/969 74/18722 0.00466605381022679 0.0404364636807068 GRN/GAA/HOOK2/SYT7/ABCA1/GNPTAB/MBTPS1/NAGLU/HOOK3/ATP6AP2 10 GO:0051693 actin filament capping 7/969 41/18722 0.00467729065732952 0.0404364636807068 SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/EPS8/ADD3 7 GO:0071634 regulation of transforming growth factor beta production 7/969 41/18722 0.00467729065732952 0.0404364636807068 CD46/ITGAV/LTBP1/ITGB8/FERMT1/ATP6AP2/CD24 7 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 4/969 14/18722 0.00470279929778714 0.0404364636807068 FBLN1/KANK1/ACTN4/TACSTD2 4 GO:0042415 norepinephrine metabolic process 4/969 14/18722 0.00470279929778714 0.0404364636807068 LY6E/EPAS1/AKR1B1/GATA3 4 GO:0051645 Golgi localization 4/969 14/18722 0.00470279929778714 0.0404364636807068 ARHGAP21/HOOK3/CDC42/UVRAG 4 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 4/969 14/18722 0.00470279929778714 0.0404364636807068 CAV1/AKAP13/ATP2B4/PDE4B 4 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 4/969 14/18722 0.00470279929778714 0.0404364636807068 FBLN1/KANK1/ACTN4/TACSTD2 4 GO:1901722 regulation of cell proliferation involved in kidney development 4/969 14/18722 0.00470279929778714 0.0404364636807068 EGR1/BMP7/CFLAR/GATA3 4 GO:0072331 signal transduction by p53 class mediator 17/969 163/18722 0.00470443358550894 0.0404364636807068 RPL26/MIF/ATRX/RPL11/RPS20/DDX5/SOX4/NPM1/PMAIP1/USP10/EIF5A/EP300/MDM4/TRIM24/PTTG1IP/TAF9/AURKA 17 GO:0014031 mesenchymal cell development 11/969 86/18722 0.00472441320592936 0.0404750547773555 NRP2/SEMA6A/LAMA5/SEMA6D/ISL1/NRP1/JAG1/BMP7/CITED2/PDCD6/HES1 11 GO:2001251 negative regulation of chromosome organization 11/969 86/18722 0.00472441320592936 0.0404750547773555 ATRX/DUSP1/PARP1/TPR/RAD50/HNRNPA1/HNRNPC/HNRNPU/LCMT1/CCNB1/PTTG1 11 GO:0031098 stress-activated protein kinase signaling cascade 23/969 247/18722 0.00478366311448841 0.0409155866388158 EGFR/APP/ZFP36L1/GADD45B/PRDX1/DUSP1/DLG1/GSTP1/PPIA/IGF1R/MAP3K4/RB1CC1/RHOA/NCOR1/HACD3/TAOK3/AKR1B1/TAOK1/MAPK14/CDC42/EMC10/EZR/PRMT1 23 GO:0009746 response to hexose 21/969 219/18722 0.00489942510786007 0.0416770288396202 LDHA/LRP1/KRT18/DYNLL1/GJA1/SOX4/TRA2B/EGR1/LRP5/IGF1R/PHPT1/KIF5B/RHOA/CTSV/CCDC186/TCF7L2/XBP1/HMGN3/GCLM/VAMP2/SRI 21 GO:0090090 negative regulation of canonical Wnt signaling pathway 15/969 137/18722 0.0049013322252119 0.0416770288396202 CAV1/TLE4/CTNND1/ISL1/EGR1/ZNRF3/GLI3/FERMT1/LATS2/TCF7L2/CHD8/MAPK14/DDIT3/SIAH2/TPBG 15 GO:0072171 mesonephric tubule morphogenesis 9/969 63/18722 0.00491256214412669 0.0416770288396202 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/TACSTD2/GATA3/HES1 9 GO:1904589 regulation of protein import 9/969 63/18722 0.00491256214412669 0.0416770288396202 CDH1/TPR/RAN/GLI3/FERMT1/PIK3R1/UBR5/MAPK14/CDK1 9 GO:2000756 regulation of peptidyl-lysine acetylation 9/969 63/18722 0.00491256214412669 0.0416770288396202 SOX4/ISL1/ZNF451/BRD7/RPS6KA5/SETD5/EID1/GATA3/IWS1 9 GO:0021545 cranial nerve development 8/969 52/18722 0.00496352986533679 0.0418098938645893 NRP2/RPL24/ISL1/NRP1/GLI3/TFAP2A/CITED2/HES1 8 GO:0031103 axon regeneration 8/969 52/18722 0.00496352986533679 0.0418098938645893 LRP1/DAG1/GRN/ISL1/PTPRF/JAM3/MTR/NREP 8 GO:0035196 production of miRNAs involved in gene silencing by miRNA 8/969 52/18722 0.00496352986533679 0.0418098938645893 EGFR/DDX5/PUM1/DICER1/NCOR1/PUM2/ADAR/AGO2 8 GO:0043392 negative regulation of DNA binding 8/969 52/18722 0.00496352986533679 0.0418098938645893 JUN/TMSB4X/RSF1/NFKBIA/DDIT3/ID1/HMOX1/SRI 8 GO:0048880 sensory system development 32/969 381/18722 0.00496822504590699 0.0418098938645893 FBN1/FBN2/ATP2B1/RPL24/TENM3/PBX1/ISL1/DLG1/TUG1/LRP5/NRP1/NIPBL/CRYBG3/FAT1/GLI3/NF1/KDM5B/EFEMP1/ATP2B4/AHI1/SMOC1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/GATA3/MFAP5/IMPDH2 32 GO:0048568 embryonic organ development 35/969 427/18722 0.00500224518734992 0.0419677864820298 FBN1/FBN2/KRT19/KRT8/BPTF/ZFP36L1/PBX1/IGF2/RPL10/SPINT1/NR2F2/TRA2B/DLG1/NIPBL/BIRC6/HECTD1/SETD2/GLI3/TBX3/EFEMP1/EPAS1/TEAD1/AHI1/JUNB/RBBP6/TFAP2A/TRIOBP/MMP14/BMP7/RBPJ/NAGLU/CITED2/GATA3/HES1/MFAP5 35 GO:0050792 regulation of viral process 17/969 164/18722 0.00500304840763578 0.0419677864820298 DDX5/DDB1/PPIA/PKN2/LY6E/MPHOSPH8/HACD3/RSF1/LARP1/ADAR/P4HB/PABPC1/KPNA6/BANF1/CAV2/DYNLT1/KPNA2 17 GO:0051960 regulation of nervous system development 36/969 443/18722 0.00510963451365813 0.0427720730583648 EGFR/LRP2/LRP1/GOLGA4/SEMA6A/DAG1/MACF1/DLG5/SPINT1/SEMA6D/CUX1/IL6ST/CTSC/DLG1/NRP1/UFL1/GLI3/NF1/DICER1/BHLHE41/PCM1/RAB11A/MAN2A1/PLXNB1/PRTG/BMP7/CLSTN1/MME/RTN4/HOOK3/OBSL1/REST/ID1/TPBG/HES1/DYNLT1 36 GO:0035265 organ growth 18/969 178/18722 0.00511529767728243 0.0427720730583648 IGF2/GJA1/TGFBR3/DUSP6/AKAP13/PSAP/LY6E/LATS2/JARID2/DDX39B/YY1/MAPK14/SLC6A4/RBPJ/VGLL4/CITED2/CDK1/CCNB1 18 GO:0008088 axo-dendritic transport 10/969 75/18722 0.00514053420853662 0.0429144277536939 ARMCX3/APP/DYNC1H1/DST/HSPB1/KIF5B/PURA/FLOT2/SFPQ/HNRNPU 10 GO:0017038 protein import 20/969 206/18722 0.00518595388265563 0.0432245534142876 CDH1/PPP1R10/RANBP2/TPR/RAN/GLI3/FERMT1/PIK3R1/FAM53C/TNPO1/UBR5/KPNB1/MAPK14/NFKBIA/KPNA6/CDK1/PTTG1IP/DNAJC15/KPNA2/SEC13 20 GO:0055007 cardiac muscle cell differentiation 14/969 125/18722 0.00527374414042809 0.0438862848373841 ITGB1/PLEC/ISL1/AKAP13/TBX3/SLC9A1/DDX39B/YY1/RBPJ/OBSL1/CDK1/HNRNPU/CACYBP/CCNB1 14 GO:0046661 male sex differentiation 17/969 165/18722 0.00531697132409201 0.044175663179181 LRP2/SF1/ADGRG1/ATRX/LGR4/EIF2S2/KDM5A/DHCR24/TBX3/SMAD5/CTSV/MMP14/RHOBTB3/ARID5B/CITED2/TMF1/GATA3 17 GO:0035019 somatic stem cell population maintenance 7/969 42/18722 0.00536727108696924 0.0443818966780083 SOX4/LRP5/BMP7/RBPJ/REST/LBH/HES1 7 GO:0072595 maintenance of protein localization in organelle 7/969 42/18722 0.00536727108696924 0.0443818966780083 HSPA5/GJA1/SKP1/TXN/TAF3/HNRNPU/KDELR2 7 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 7/969 42/18722 0.00536727108696924 0.0443818966780083 JUN/FOS/EGR1/TEAD1/NR3C1/GATA3/KLF5 7 GO:0007435 salivary gland morphogenesis 6/969 32/18722 0.00539217685742946 0.0444471865251204 DAG1/LAMA5/NRP1/NFIB/BMP7/CDC42 6 GO:0072337 modified amino acid transport 6/969 32/18722 0.00539217685742946 0.0444471865251204 LRP2/GJA1/SLC38A2/SLC16A12/SLC19A1/SLC13A3 6 GO:0031346 positive regulation of cell projection organization 30/969 353/18722 0.00542385842168048 0.0446379277349641 LRP1/GOLGA4/ITGA6/TENM3/PFN1/HSPA5/GRN/MACF1/IQGAP1/CUX1/WASF2/NRP1/KIDINS220/EPS8L1/PPP1R9A/S100A9/ATMIN/RAB11A/PIK3R1/PLXNB1/CREB3L2/BMP7/EP300/SETX/RREB1/CFLAR/CDC42/EPS8/OBSL1/DYNLT1 30 GO:0006749 glutathione metabolic process 9/969 64/18722 0.00546036417079825 0.0447972734012428 CLIC3/GSTO1/GPX4/GSTP1/GPX1/CLIC1/IDH1/GCLM/GSTA3 9 GO:0048857 neural nucleus development 9/969 64/18722 0.00546036417079825 0.0447972734012428 DYNLL1/HSPA5/RHOA/NFIB/CALM1/CDC42/YWHAE/CALM2/YWHAQ 9 GO:0016573 histone acetylation 16/969 152/18722 0.00548507583283974 0.0449294769630415 ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/PHF20L1/EP300/PHF14/SETD5/PHF20/EID1/GATA3/IWS1/TAF9 16 GO:0009896 positive regulation of catabolic process 39/969 492/18722 0.00553903227597006 0.0453004423696706 LRP2/LRP1/CAV1/APP/KCNQ1OT1/ZFP36L1/GJA1/DDB1/CTSC/ROCK1/PUM1/TNRC6B/UFL1/OAZ1/HECTD1/HSPA1A/HUWE1/DDA1/TNRC6A/CELF1/LARP1/WAC/AGO2/RAB3GAP2/VGLL4/TMEM259/BTG2/MYLIP/PABPC1/UVRAG/HSPA1B/EZR/HMOX1/VDAC1/PTTG1IP/NDUFA13/CDC20/PSMC1/AURKA 39 GO:0010948 negative regulation of cell cycle process 26/969 294/18722 0.00557900717322066 0.0455491860163949 RPL26/ZFP36L1/ATRX/PRKDC/SOX4/PPP1R10/DUSP1/DLG1/NPM1/TPR/USP47/CTDSPL/BRD7/TAOK3/FOXN3/TAOK1/DDX39B/WAC/BMP7/MAPK14/EIF2AK4/XPC/CDK1/LCMT1/CCNB1/PTTG1 26 GO:0032784 regulation of DNA-templated transcription, elongation 8/969 53/18722 0.00558687872876179 0.0455491860163949 BRD4/TCERG1/ZNF326/DDX39B/CDK12/SUPT6H/SETD5/HNRNPU 8 GO:0051783 regulation of nuclear division 15/969 139/18722 0.00560511219163741 0.0456266609244503 IGF2/DUSP1/LRP5/PHIP/TPR/ANAPC11/BMP7/CDC42/OBSL1/CAV2/LCMT1/NUSAP1/CDC20/CCNB1/AURKA 15 GO:0043112 receptor metabolic process 17/969 166/18722 0.00564677003815561 0.0458616914273836 LRP1/CAV1/ITGB1/RNF43/CD63/ANXA2/CLTC/ZNRF3/TFRC/AHI1/FUT8/LRPAP1/ATXN2/MYLIP/UVRAG/EZR/VAMP3 17 GO:0030325 adrenal gland development 5/969 23/18722 0.00566908776542093 0.0458616914273836 PBX1/LY6E/NF1/ARID5B/CITED2 5 GO:0035994 response to muscle stretch 5/969 23/18722 0.00566908776542093 0.0458616914273836 FOS/SLC9A1/DMD/MAPK14/NFKBIA 5 GO:1904666 regulation of ubiquitin protein ligase activity 5/969 23/18722 0.00566908776542093 0.0458616914273836 RPL11/RPS20/SKP1/UBE2C/CDC20 5 GO:0002573 myeloid leukocyte differentiation 20/969 208/18722 0.00576713120906216 0.0465827321461497 FBN1/JUN/FOS/APP/ZFP36L1/CDK6/DHRS2/ANXA2/PARP1/ITGB8/TFRC/PIK3R1/JUNB/FOXP1/ESRRA/MAPK14/RBPJ/CITED2/CDC42/GATA3 20 GO:0042326 negative regulation of phosphorylation 32/969 385/18722 0.00578463742175282 0.0466520295772843 LRP1/CAV1/DYNLL1/FBLN1/GADD45B/PRKDC/NR2F2/PLEC/DUSP6/HSPB1/PLPP3/DUSP1/ROCK1/NPM1/GSTP1/LRP5/PPIA/GNAQ/NF1/CTDSPL/EIF4G1/NCOR1/LATS2/DMD/CALM1/ADAR/BMP7/WNK1/SPAG9/CALM2/HNRNPU/CCNB1 32 GO:1903034 regulation of response to wounding 17/969 167/18722 0.0059930224306807 0.0482581436405814 LRP1/CAV1/ITGB1/ACTG1/KANK1/GRN/GJA1/ANXA1/PLPP3/ANXA2/PTPRF/CLDN4/FERMT1/XBP1/RREB1/ARFGEF1/SRSF6 17 GO:0090307 mitotic spindle assembly 9/969 65/18722 0.00605421133053259 0.048656257108264 TPR/HSPA1A/RAB11A/RHOA/KPNB1/STAG1/HSPA1B/HNRNPU/CDC20 9 GO:0001654 eye development 31/969 371/18722 0.00606108369259087 0.048656257108264 FBN1/FBN2/ATP2B1/RPL24/TENM3/PBX1/DLG1/TUG1/LRP5/NRP1/NIPBL/CRYBG3/FAT1/GLI3/NF1/KDM5B/EFEMP1/ATP2B4/AHI1/SMOC1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/GATA3/MFAP5/IMPDH2 31 GO:0001709 cell fate determination 7/969 43/18722 0.00613079279259467 0.0487964172797448 ISL1/IFRD1/MCL1/JAG1/CDC42/GATA3/HES1 7 GO:0061383 trabecula morphogenesis 7/969 43/18722 0.00613079279259467 0.0487964172797448 FBN2/ADAMTS1/TGFBR3/RHOA/PLXNB1/BMP7/RBPJ 7 GO:0032239 regulation of nucleobase-containing compound transport 4/969 15/18722 0.00615324129111209 0.0487964172797448 TPR/SETD2/SUPT6H/IWS1 4 GO:0045176 apical protein localization 4/969 15/18722 0.00615324129111209 0.0487964172797448 DLG5/JAM3/GOPC/ARF4 4 GO:0045475 locomotor rhythm 4/969 15/18722 0.00615324129111209 0.0487964172797448 ZFHX3/EGR1/NCOR1/NAGLU 4 GO:0051284 positive regulation of sequestering of calcium ion 4/969 15/18722 0.00615324129111209 0.0487964172797448 GSTO1/CALM1/CALM2/SRI 4 GO:0086069 bundle of His cell to Purkinje myocyte communication 4/969 15/18722 0.00615324129111209 0.0487964172797448 DSP/DSG2/DSC2/GJA5 4 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/969 15/18722 0.00615324129111209 0.0487964172797448 ZFP36L1/TNRC6B/AGO2/PABPC1 4 GO:1901983 regulation of protein acetylation 10/969 77/18722 0.00620230341860615 0.0491109661600542 SOX4/ISL1/ZNF451/BRD7/RPS6KA5/TAOK1/SETD5/EID1/GATA3/IWS1 10 GO:0031050 dsRNA processing 8/969 54/18722 0.0062681148499032 0.0493330846469791 EGFR/DDX5/PUM1/DICER1/NCOR1/PUM2/ADAR/AGO2 8 GO:0035065 regulation of histone acetylation 8/969 54/18722 0.0062681148499032 0.0493330846469791 ISL1/ZNF451/BRD7/RPS6KA5/SETD5/EID1/GATA3/IWS1 8 GO:0070839 metal ion export 8/969 54/18722 0.0062681148499032 0.0493330846469791 ATP2B1/DLG1/ATP2B4/SLC9A1/SLC40A1/CALM1/YWHAE/CALM2 8 GO:0070918 production of small RNA involved in gene silencing by RNA 8/969 54/18722 0.0062681148499032 0.0493330846469791 EGFR/DDX5/PUM1/DICER1/NCOR1/PUM2/ADAR/AGO2 8 GO:0031116 positive regulation of microtubule polymerization 6/969 33/18722 0.00630753794576309 0.0494942842410779 AKAP9/CLIP1/MET/RPS3/HSPA1A/HSPA1B 6 GO:1901976 regulation of cell cycle checkpoint 6/969 33/18722 0.00630753794576309 0.0494942842410779 PPP1R10/DUSP1/TPR/DDX39B/LCMT1/CCNB1 6 GO:1902749 regulation of cell cycle G2/M phase transition 12/969 102/18722 0.00640405541241689 0.0501763022268226 APP/PBX1/BRD4/NPM1/USP47/RAB11A/TAOK3/FOXN3/TAOK1/CDK1/CCNB1/AURKA 12 GO:0061138 morphogenesis of a branching epithelium 18/969 182/18722 0.00642698888155582 0.0502806046332496 DAG1/LAMA5/MET/PBX1/DLG5/SPINT1/LGR4/DLG1/MAGED1/LRP5/NRP1/GLI3/TBX3/KDM5B/MMP14/BMP7/TACSTD2/KRAS 18 GO:0045664 regulation of neuron differentiation 19/969 196/18722 0.00643823814219461 0.0502933221690718 APP/PBX1/ZFHX3/ISL1/ROCK1/TUG1/GLI3/EIF4G1/RHOA/JAG1/BMP7/SLC6A4/EIF2AK4/NREP/SPAG9/REST/HES1/TIMP2/HMG20B 19 GO:0050708 regulation of protein secretion 24/969 268/18722 0.0064905391522721 0.0505938187014876 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANXA1/ISL1/LRP5/PPIA/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/SYT7/EXPH5/TCF7L2/HMGN3/DPP4/REST/EZR/SRI 24 GO:0035303 regulation of dephosphorylation 14/969 128/18722 0.00649606818765751 0.0505938187014876 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/ROCK1/PPIA/CSNK2B/PPP1R12A/PPP6R2/LGALS3/CALM1/SPPL3/YWHAE/CALM2 14 GO:0000077 DNA damage checkpoint signaling 13/969 115/18722 0.00651198805666989 0.0506423356907096 RPL26/PRKDC/SOX4/PPP1R10/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/XPC/CDK1 13 GO:0044262 cellular carbohydrate metabolic process 25/969 283/18722 0.00657432294744514 0.0510511318326127 TPI1/IGF2/AGL/DDB1/IL6ST/GAA/RANBP2/PTGES3/PMAIP1/PHKB/RB1CC1/SLC5A3/NCOR1/GNPTAB/SORBS1/AKR1B1/EP300/B4GALT5/IDH1/UGP2/B3GNT2/PYGL/SLC35B4/PGAM1/LCMT1 25 GO:0010720 positive regulation of cell development 26/969 298/18722 0.00662708854002218 0.0513845173741185 EGFR/LRP2/LRP1/GOLGA4/DAG1/MACF1/PRKDC/SPINT1/CUX1/S100A10/IL6ST/NRP1/UFL1/GLI3/DICER1/RAB11A/MAN2A1/PLXNB1/TRIOBP/P4HB/RREB1/MME/CDC42/OBSL1/HES1/AURKA 26 GO:0032392 DNA geometric change 11/969 90/18722 0.00666919094715743 0.0515579761684093 ATRX/ANXA1/HMGB3/CHD2/RAD50/PURA/CHD4/CHD8/HMGA1/SETX/CHD6 11 GO:0034644 cellular response to UV 11/969 90/18722 0.00666919094715743 0.0515579761684093 RPL26/DDB1/NPM1/PARP1/USP47/PIK3R1/YY1/EP300/EIF2AK4/MME/XPC 11 GO:0045600 positive regulation of fat cell differentiation 9/969 66/18722 0.00669656028857219 0.0516930931581658 ZFP36L1/LRP5/BMP7/MAPK14/ADIRF/XBP1/RREB1/KLF5/HNRNPU 9 GO:0000075 cell cycle checkpoint signaling 17/969 169/18722 0.00673724892091138 0.0517777395010042 RPL26/PRKDC/SOX4/PPP1R10/DUSP1/TPR/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/XPC/CDK1/LCMT1/CCNB1 17 GO:0006937 regulation of muscle contraction 17/969 169/18722 0.00673724892091138 0.0517777395010042 AKAP9/ATP2B1/CAV1/DSP/GSTO1/ENO1/DLG1/DSG2/DSC2/PDE4B/SLC9A1/RHOA/DMD/CALM1/GJA5/CALM2/SRI 17 GO:0018394 peptidyl-lysine acetylation 17/969 169/18722 0.00673724892091138 0.0517777395010042 SOX4/ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/PHF20L1/EP300/PHF14/SETD5/PHF20/EID1/GATA3/IWS1/TAF9 17 GO:0071248 cellular response to metal ion 19/969 197/18722 0.00679096992918723 0.0520562045236923 JUN/EGFR/FOS/CDH1/FUS/JUND/FOSB/APP/HSPA5/IQGAP1/ANK3/PARP1/SYT7/JUNB/TFAP2A/WNK1/HMOX1/CACYBP/CCNB1 19 GO:0043297 apical junction assembly 10/969 78/18722 0.00679340441736666 0.0520562045236923 DLG5/GJA1/DLG1/ROCK1/PKN2/CLDN4/RHOA/VCL/RHOC/CLDN7 10 GO:0009306 protein secretion 30/969 359/18722 0.00685099813307934 0.0522677072382174 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANXA1/ISL1/MIA3/LRP5/PPIA/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/SYT7/SEL1L/EXPH5/ABCA1/GNPTAB/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/EZR/SRI 30 GO:0016486 peptide hormone processing 5/969 24/18722 0.00686101170405991 0.0522677072382174 ENPEP/CTSL/PCSK7/MME/ATP6AP2 5 GO:0030859 polarized epithelial cell differentiation 5/969 24/18722 0.00686101170405991 0.0522677072382174 DLG5/FAT1/AHI1/RHOA/CDC42 5 GO:0051647 nucleus localization 5/969 24/18722 0.00686101170405991 0.0522677072382174 SYNE2/DYNC1H1/PCM1/HOOK3/CDC42 5 GO:0007093 mitotic cell cycle checkpoint signaling 14/969 129/18722 0.00695038819705251 0.052871511961858 RPL26/PRKDC/SOX4/PPP1R10/DUSP1/TPR/TAOK3/FOXN3/TAOK1/WAC/XPC/CDK1/LCMT1/CCNB1 14 GO:0060711 labyrinthine layer development 7/969 44/18722 0.00697242952660341 0.0528852201829164 ZFP36L1/SPINT1/BIRC6/JUNB/BMP7/RBPJ/HES1 7 GO:0062208 positive regulation of pattern recognition receptor signaling pathway 7/969 44/18722 0.00697242952660341 0.0528852201829164 CAV1/PUM1/HSPA1A/ANKRD17/PUM2/RTN4/HSPA1B 7 GO:0006338 chromatin remodeling 23/969 255/18722 0.00698927872549401 0.0529361893035242 BPTF/ATRX/RERE/NPM1/BAZ1B/BRD2/KDM5A/HP1BP3/ARID1A/SETD2/SMARCA2/KDM5B/PBRM1/JARID2/CHD4/RSF1/CHD8/HMGA1/SUPT6H/BAZ2B/BAZ2A/GATA3/HNRNPC 23 GO:0003229 ventricular cardiac muscle tissue development 8/969 55/18722 0.0070105196384374 0.0529436064024189 LRP2/DSP/TGFBR3/ISL1/DSG2/LY6E/TBX3/RBPJ 8 GO:0031113 regulation of microtubule polymerization 8/969 55/18722 0.0070105196384374 0.0529436064024189 AKAP9/CLIP1/MET/RPS3/HSPA1A/CAMSAP2/HSPA1B/STMN1 8 GO:0150063 visual system development 31/969 375/18722 0.00704574586116383 0.0531328540699021 FBN1/FBN2/ATP2B1/RPL24/TENM3/PBX1/DLG1/TUG1/LRP5/NRP1/NIPBL/CRYBG3/FAT1/GLI3/NF1/KDM5B/EFEMP1/ATP2B4/AHI1/SMOC1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/GATA3/MFAP5/IMPDH2 31 GO:0009749 response to glucose 20/969 212/18722 0.00709010219312307 0.0533903084456213 LDHA/LRP1/DYNLL1/GJA1/SOX4/TRA2B/EGR1/LRP5/IGF1R/PHPT1/KIF5B/RHOA/CTSV/CCDC186/TCF7L2/XBP1/HMGN3/GCLM/VAMP2/SRI 20 GO:0035592 establishment of protein localization to extracellular region 30/969 360/18722 0.00711678077966116 0.053514095474114 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ANXA1/ISL1/MIA3/LRP5/PPIA/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/SYT7/SEL1L/EXPH5/ABCA1/GNPTAB/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/EZR/SRI 30 GO:0001657 ureteric bud development 11/969 91/18722 0.00724156375146941 0.0542183555375059 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/SMAD5/BMP7/TACSTD2/GATA3/HES1 11 GO:0014033 neural crest cell differentiation 11/969 91/18722 0.00724156375146941 0.0542183555375059 NRP2/SEMA6A/LAMA5/SEMA6D/ISL1/NRP1/JAG1/BMP7/CITED2/PDCD6/HES1 11 GO:0051983 regulation of chromosome segregation 11/969 91/18722 0.00724156375146941 0.0542183555375059 DUSP1/PUM1/TPR/ANAPC11/PUM2/NEK6/UBE2C/HNRNPU/LCMT1/CCNB1/PTTG1 11 GO:0007411 axon guidance 21/969 227/18722 0.00733001040728951 0.0546513416145179 NRP2/LRP1/RPL24/SEMA6A/APP/DAG1/LAMA5/MYCBP2/SEMA6D/EPHB4/ISL1/NRP1/KIF5B/GLI3/RPS6KA5/PLXNB1/NFIB/SIAH1/BMP7/B3GNT2/GATA3 21 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 6/969 34/18722 0.00733076740753484 0.0546513416145179 RPL26/MIF/DDX5/NPM1/PMAIP1/PTTG1IP 6 GO:0051085 chaperone cofactor-dependent protein refolding 6/969 34/18722 0.00733076740753484 0.0546513416145179 HSPA5/PTGES3/HSPA1A/DNAJB1/DNAJB14/HSPA1B 6 GO:0035914 skeletal muscle cell differentiation 9/969 67/18722 0.00738989595635857 0.055013669897336 FOS/DDX5/DDX17/EGR1/GPC1/CITED2/BTG2/KLF5/HMG20B 9 GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 14/969 130/18722 0.00742967277486754 0.0552311094188588 LMAN1/TRIP11/MIA3/PGAP1/SEC31A/COPA/CREB3L2/TRAPPC1/PDCD6/GOPC/COPB1/ARF4/KDELR2/SEC13 14 GO:0001837 epithelial to mesenchymal transition 16/969 157/18722 0.00745223358394131 0.0553201316898825 DAG1/DLG5/DDX5/TGFBR3/DDX17/ISL1/ROCK1/TBX3/GCNT2/JAG1/TCF7L2/BMP7/RBPJ/RTN4/PDCD6/GATA3 16 GO:0000280 nuclear division 35/969 439/18722 0.00761263340118653 0.056430669722838 RPL24/ATRX/IGF2/DUSP1/LRP5/NIPBL/PHIP/TPR/HSPA1A/RAN/RAD50/RAB11A/ANAPC11/RHOA/PDS5A/EML4/KPNB1/BMP7/NEK6/UBE2C/STAG1/CDC42/EPS8/OBSL1/HSPA1B/CAV2/HNRNPU/LCMT1/NUSAP1/CDC20/RANBP1/CCNB1/PTTG1/CCNE1/AURKA 35 GO:0097485 neuron projection guidance 21/969 228/18722 0.0076931574810014 0.0567563749383795 NRP2/LRP1/RPL24/SEMA6A/APP/DAG1/LAMA5/MYCBP2/SEMA6D/EPHB4/ISL1/NRP1/KIF5B/GLI3/RPS6KA5/PLXNB1/NFIB/SIAH1/BMP7/B3GNT2/GATA3 21 GO:0048255 mRNA stabilization 8/969 56/18722 0.00781739814866296 0.0567563749383795 FUS/YBX1/LARP1/MAPK14/THRAP3/PABPC1/HNRNPC/HNRNPU 8 GO:0051056 regulation of small GTPase mediated signal transduction 26/969 302/18722 0.00783301247956023 0.0567563749383795 ITGAV/ITGB1/MET/KANK1/ADGRG1/RASA1/DOCK8/AKAP13/NRP1/EPS8L1/ARHGAP21/DENND4C/SYDE2/ARHGAP5/ARHGAP32/ABCA1/AMOT/ARHGAP18/FAM13A/ARHGAP23/ARFGEF1/EPS8/KRAS/DYNLT1/TIMP2/STMN1 26 GO:0000082 G1/S transition of mitotic cell cycle 20/969 214/18722 0.00783879353950853 0.0567563749383795 EGFR/RPS6/RPL26/ITGB1/ADAMTS1/PRKDC/BRD4/SOX4/ANXA1/CDK6/DLG1/CTDSPL/BRD7/EIF4G1/LATS2/ANKRD17/WAC/PSME2/CDKN3/CCNE1 20 GO:0072163 mesonephric epithelium development 11/969 92/18722 0.00785153515577645 0.0567563749383795 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/SMAD5/BMP7/TACSTD2/GATA3/HES1 11 GO:0072164 mesonephric tubule development 11/969 92/18722 0.00785153515577645 0.0567563749383795 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/SMAD5/BMP7/TACSTD2/GATA3/HES1 11 GO:0005980 glycogen catabolic process 4/969 16/18722 0.00787276752765262 0.0567563749383795 AGL/GAA/RB1CC1/PYGL 4 GO:0009415 response to water 4/969 16/18722 0.00787276752765262 0.0567563749383795 KRT8/PLEC/ATP2B4/AKR1B1 4 GO:0021783 preganglionic parasympathetic fiber development 4/969 16/18722 0.00787276752765262 0.0567563749383795 NRP2/NRP1/TFAP2A/HES1 4 GO:0033631 cell-cell adhesion mediated by integrin 4/969 16/18722 0.00787276752765262 0.0567563749383795 ITGB1/PLPP3/WNK1/DPP4 4 GO:0090231 regulation of spindle checkpoint 4/969 16/18722 0.00787276752765262 0.0567563749383795 DUSP1/TPR/LCMT1/CCNB1 4 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 4/969 16/18722 0.00787276752765262 0.0567563749383795 DUSP1/TPR/LCMT1/CCNB1 4 GO:0090336 positive regulation of brown fat cell differentiation 4/969 16/18722 0.00787276752765262 0.0567563749383795 BMP7/MAPK14/RREB1/HNRNPU 4 GO:0097284 hepatocyte apoptotic process 4/969 16/18722 0.00787276752765262 0.0567563749383795 KRT8/KRT18/DNMT3A/CFLAR 4 GO:0099010 modification of postsynaptic structure 4/969 16/18722 0.00787276752765262 0.0567563749383795 PFN1/MYH10/RHOA/CDC42 4 GO:1903504 regulation of mitotic spindle checkpoint 4/969 16/18722 0.00787276752765262 0.0567563749383795 DUSP1/TPR/LCMT1/CCNB1 4 GO:0051090 regulation of DNA-binding transcription factor activity 35/969 440/18722 0.00787377316452146 0.0567563749383795 CAV1/APP/RPS3/PLPP3/NPM1/LRP5/PPIA/TMSB4X/UFL1/KDM5A/ERC1/HSPA1A/ANXA4/S100A9/TFRC/PURA/RPS6KA5/CREBZF/TCF7L2/BMP7/EP300/EIF2AK4/TAF3/ARID5B/CFLAR/NFKBIA/DDIT3/FLOT2/HSPA1B/ID1/KRAS/HMOX1/ANXA3/HES1/SRI 35 GO:0003197 endocardial cushion development 7/969 45/18722 0.00789676381336173 0.0567563749383795 ISL1/TBX3/JAG1/BMP7/MDM4/RBPJ/CITED2 7 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/969 45/18722 0.00789676381336173 0.0567563749383795 HSPB1/PPIA/GPX1/PARP1/MCL1/P4HB/SFPQ 7 GO:0030835 negative regulation of actin filament depolymerization 7/969 45/18722 0.00789676381336173 0.0567563749383795 SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/EPS8/ADD3 7 GO:0035307 positive regulation of protein dephosphorylation 7/969 45/18722 0.00789676381336173 0.0567563749383795 SLC39A10/PPP1R15A/PPIA/PPP1R12A/CALM1/SPPL3/CALM2 7 GO:0048538 thymus development 7/969 45/18722 0.00789676381336173 0.0567563749383795 PBX1/PRKDC/LMO4/JARID2/CITED2/GATA3/HES1 7 GO:0018393 internal peptidyl-lysine acetylation 16/969 158/18722 0.00790636068793347 0.0567563749383795 ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/PHF20L1/EP300/PHF14/SETD5/PHF20/EID1/GATA3/IWS1/TAF9 16 GO:0045444 fat cell differentiation 21/969 229/18722 0.00807081778003278 0.0578574673778482 ZFP36L1/LRP5/GPX1/ADRB1/NIPBL/JAG1/TCF7L2/ANKRD26/BMP7/MAPK14/EP300/ADIRF/XBP1/ARID5B/RREB1/DDIT3/GATA3/KLF5/ARL4A/HES1/HNRNPU 21 GO:0007422 peripheral nervous system development 10/969 80/18722 0.00810576166385646 0.057869823026385 ITGB4/DAG1/PLEC/ISL1/NF1/DICER1/SLC5A3/GPC1/CITED2/CDK1 10 GO:0009791 post-embryonic development 10/969 80/18722 0.00810576166385646 0.057869823026385 FBN1/ATRX/ASH1L/KDM5B/EFEMP1/CCDC47/AGO2/ZFX/ARID5B/GATA3 10 GO:0032204 regulation of telomere maintenance 10/969 80/18722 0.00810576166385646 0.057869823026385 ATRX/PPP1R10/PARP1/MAP3K4/RAD50/HNRNPA1/SMG1/HNRNPC/HNRNPU/CCT8 10 GO:1902305 regulation of sodium ion transmembrane transport 9/969 68/18722 0.00813672577067576 0.0580104405438515 UTRN/ANK3/DLG1/KIF5B/ATP2B4/SLC9A1/DMD/WNK1/ACTN4 9 GO:0015980 energy derivation by oxidation of organic compounds 27/969 318/18722 0.00814765850730711 0.0580104405438515 IGF2/AGL/PLEC/IL6ST/GAA/COX6A1/UQCRH/PTGES3/PHKB/COX8C/RB1CC1/RHOA/SORBS1/COX5A/IDH1/UGP2/PYGL/UQCRQ/COX7B/CDK1/DNAJC15/GHITM/MDH2/STOML2/NDUFA6/CCNB1/SDHC 27 GO:0016540 protein autoprocessing 5/969 25/18722 0.00821757898149003 0.0582701055051111 PARP1/CTSL/PISD/AFG3L2/CASP4 5 GO:0090169 regulation of spindle assembly 5/969 25/18722 0.00821757898149003 0.0582701055051111 DYNC1H1/TPR/HSPA1A/HSPA1B/HNRNPU 5 GO:0140448 signaling receptor ligand precursor processing 5/969 25/18722 0.00821757898149003 0.0582701055051111 ENPEP/CTSL/PCSK7/MME/ATP6AP2 5 GO:0032259 methylation 30/969 364/18722 0.00826698570618518 0.0585410126023357 FOS/ZC3H13/ATRX/BRD4/ASH1L/KMT2C/TET2/RIF1/PARP1/BTG1/SETD2/MTR/MPHOSPH8/NSD1/JARID2/RAB6A/PAXBP1/MTF2/DNMT3A/RTF1/SUPT6H/SETD5/BAZ2A/RNMT/BTG2/METTL7A/GATA3/IWS1/LCMT1/PRMT1 30 GO:0007569 cell aging 14/969 132/18722 0.00846688679848779 0.059645404265184 MIF/PRKDC/CDK6/NPM1/YBX1/TBX3/PAWR/HMGA1/MAPK14/NEK6/MME/CITED2/CDK1/KRAS 14 GO:0035264 multicellular organism growth 14/969 132/18722 0.00846688679848779 0.059645404265184 APP/ZFP36L1/ATRX/IGF2/PLEC/ADRB1/NIPBL/RBBP6/CELF1/EP300/ZFX/ARID5B/AFG3L2/EZR 14 GO:0060236 regulation of mitotic spindle organization 6/969 35/18722 0.0084685973908853 0.059645404265184 DYNC1H1/CLTC/TPR/HSPA1A/HSPA1B/HNRNPU 6 GO:1905898 positive regulation of response to endoplasmic reticulum stress 6/969 35/18722 0.0084685973908853 0.059645404265184 CAV1/PMAIP1/PIK3R1/XBP1/TMEM259/DDIT3 6 GO:0060349 bone morphogenesis 11/969 93/18722 0.00850070195233853 0.0597909399770136 GLG1/TRIP11/LRP5/GLI3/TFAP2A/FOXN3/MMP14/LTBP3/TMEM107/CITED2/SERPINH1 11 GO:0006090 pyruvate metabolic process 12/969 106/18722 0.00865240769557764 0.0607761863132913 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/VDAC1/PGAM1/PGK1 12 GO:0006611 protein export from nucleus 8/969 57/18722 0.00869206922509182 0.0609626524660224 PTPN14/TPR/RAN/TXN/TCF7L2/AHCYL1/XPO1/YWHAE 8 GO:0022411 cellular component disassembly 35/969 443/18722 0.00870228448902654 0.0609626524660224 LRP1/LAMC1/CFL1/IGF1R/UFL1/VPS13C/HUWE1/ARID1A/KIF5B/DICER1/SCIN/RB1CC1/SPTBN1/SPTAN1/PIK3R1/CAMSAP2/CTSV/SVIL/TRIOBP/MMP14/TAOK1/CALM1/EIF5A/HMGA1/MMP15/NEK6/SETX/DPP4/UVRAG/EPS8/ADD3/CDK1/VDAC1/UFC1/STMN1 35 GO:0090150 establishment of protein localization to membrane 23/969 260/18722 0.00874959935901274 0.0612120565598401 TCAF1/EGFR/GOLGA4/KRT18/NACA/HSPA5/MACF1/ANK3/SPTBN1/RAB11A/SEC62/EMC1/CCDC47/CALM1/NMT1/RAB3GAP2/CLSTN1/EMC10/VAMP2/GOPC/CD24/VAMP3/NDUFA13 23 GO:0010833 telomere maintenance via telomere lengthening 10/969 81/18722 0.00883096870905381 0.0614522536265183 PARP1/MAP3K4/PTGES3/RAD50/HNRNPA1/HNRNPC/HNRNPU/NHP2/CCT8/NOP10 10 GO:0044773 mitotic DNA damage checkpoint signaling 10/969 81/18722 0.00883096870905381 0.0614522536265183 RPL26/PRKDC/SOX4/PPP1R10/TAOK3/FOXN3/TAOK1/WAC/XPC/CDK1 10 GO:0048708 astrocyte differentiation 10/969 81/18722 0.00883096870905381 0.0614522536265183 EGFR/LRP1/APP/GRN/CDK6/IL6ST/NF1/S100A9/KRAS/HES1 10 GO:2001021 negative regulation of response to DNA damage stimulus 10/969 81/18722 0.00883096870905381 0.0614522536265183 TPT1/MIF/RPS3/PPP1R10/RIF1/USP47/UBR5/DDX39B/PTTG1IP/TAF9 10 GO:0045732 positive regulation of protein catabolic process 21/969 231/18722 0.00887133924709349 0.0616360560552495 LRP2/LRP1/CAV1/GJA1/DDB1/CTSC/OAZ1/HECTD1/HSPA1A/HUWE1/DDA1/VGLL4/TMEM259/MYLIP/HSPA1B/EZR/PTTG1IP/NDUFA13/CDC20/PSMC1/AURKA 21 GO:0006475 internal protein amino acid acetylation 16/969 160/18722 0.00888097018936144 0.0616360560552495 ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/PHF20L1/EP300/PHF14/SETD5/PHF20/EID1/GATA3/IWS1/TAF9 16 GO:0006368 transcription elongation from RNA polymerase II promoter 9/969 69/18722 0.00893957382645285 0.0617965778003209 BRD4/ARID1A/SETD2/TCERG1/CDK12/SERTAD1/RTF1/SUPT6H/HNRNPU 9 GO:0007004 telomere maintenance via telomerase 9/969 69/18722 0.00893957382645285 0.0617965778003209 MAP3K4/PTGES3/RAD50/HNRNPA1/HNRNPC/HNRNPU/NHP2/CCT8/NOP10 9 GO:0034605 cellular response to heat 9/969 69/18722 0.00893957382645285 0.0617965778003209 TPR/HSPA1A/DNAJB1/SLC52A3/EP300/PDCD6/HSPA1B/HMOX1/YWHAE 9 GO:0010389 regulation of G2/M transition of mitotic cell cycle 11/969 94/18722 0.00919067597326231 0.0634484446978452 APP/PBX1/BRD4/USP47/RAB11A/TAOK3/FOXN3/TAOK1/CDK1/CCNB1/AURKA 11 GO:0060485 mesenchyme development 25/969 291/18722 0.00922662472585865 0.0635421921992117 NRP2/SEMA6A/DAG1/LAMA5/ZFP36L1/DLG5/DDX5/SEMA6D/TGFBR3/DDX17/ISL1/ROCK1/NRP1/TBX3/GCNT2/JAG1/TCF7L2/BMP7/MDM4/RBPJ/CITED2/RTN4/PDCD6/GATA3/HES1 25 GO:0032411 positive regulation of transporter activity 13/969 120/18722 0.00922857326429424 0.0635421921992117 TCAF1/AKAP9/GSTO1/ANK3/TMSB4X/KIF5B/SLC9A1/DMD/CALM1/WNK1/ACTN4/RXRA/CALM2 13 GO:0060541 respiratory system development 19/969 203/18722 0.00925156374229092 0.0636166738384373 EGFR/DAG1/LAMA5/DLG5/PTGES3/GLI3/EPAS1/MAN2A1/MMP14/NFIB/LTBP3/MAN1A2/EP300/RBPJ/MME/CDC42/SRSF6/KRAS/HES1 19 GO:0006275 regulation of DNA replication 12/969 107/18722 0.00930063573926911 0.0638700688218402 JUN/EGFR/S100A11/ATRX/PDS5A/RBBP6/ANKRD17/ZBTB38/CDC42/CDK1/CACYBP/STOML2 12 GO:0052547 regulation of peptidase activity 36/969 461/18722 0.0093717325147897 0.0642738505541876 GAPDH/ITIH5/APLP2/LRP1/CAV1/APP/CRIM1/FBLN1/GRN/SPINT1/RPS3/SERPINB9/ROCK1/ANXA2/GPX1/BIRC6/CLDN4/PMAIP1/USP47/DHCR24/S100A9/RHOA/ASPH/CTSD/SERPINB1/CFLAR/SERPINH1/SIAH2/PSME2/PDCD6/REST/SERPINB6/CSTB/NDUFA13/TIMP2/PTTG1 36 GO:1905897 regulation of response to endoplasmic reticulum stress 10/969 82/18722 0.00960485422189259 0.0655825950879543 CAV1/HSPA5/PPP1R15A/UFL1/PMAIP1/HSPA1A/PIK3R1/XBP1/TMEM259/DDIT3 10 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 14/969 134/18722 0.00961532638271449 0.0655825950879543 CAV1/RPL11/EIF3H/UFL1/HECTD1/HSPA1A/DDA1/GNA12/WAC/XPO1/HSPA1B/CDC20/TAF9/AURKA 14 GO:0061041 regulation of wound healing 14/969 134/18722 0.00961532638271449 0.0655825950879543 CAV1/ITGB1/ACTG1/KANK1/GJA1/ANXA1/PLPP3/ANXA2/CLDN4/FERMT1/XBP1/RREB1/ARFGEF1/SRSF6 14 GO:0001954 positive regulation of cell-matrix adhesion 8/969 58/18722 0.0096378555353136 0.0655825950879543 DAG1/UTRN/IQGAP1/CDK6/S100A10/ROCK1/NRP1/FERMT1 8 GO:0035904 aorta development 8/969 58/18722 0.0096378555353136 0.0655825950879543 LRP2/LRP1/ADAMTS6/SOX4/HECTD1/JAG1/RBPJ/HES1 8 GO:0043525 positive regulation of neuron apoptotic process 8/969 58/18722 0.0096378555353136 0.0655825950879543 JUN/GRN/NF1/RHOA/MCL1/TFAP2A/DDIT3/CDC42 8 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 6/969 36/18722 0.00972765707920983 0.0657415569117295 TPT1/RPL26/MIF/RPS3/USP47/TAF9 6 GO:0002026 regulation of the force of heart contraction 5/969 26/18722 0.00974927413061431 0.0657415569117295 CAV1/GAA/ADRB1/ATP2B4/SLC9A1 5 GO:0010875 positive regulation of cholesterol efflux 5/969 26/18722 0.00974927413061431 0.0657415569117295 LRP1/CAV1/ABCA1/NFKBIA/RXRA 5 GO:0033598 mammary gland epithelial cell proliferation 5/969 26/18722 0.00974927413061431 0.0657415569117295 GPX1/KDM5B/RREB1/RTN4/GATA3 5 GO:0051016 barbed-end actin filament capping 5/969 26/18722 0.00974927413061431 0.0657415569117295 SCIN/SVIL/TRIOBP/EPS8/ADD3 5 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 5/969 26/18722 0.00974927413061431 0.0657415569117295 GSTO1/DMD/CALM1/CALM2/SRI 5 GO:0060669 embryonic placenta morphogenesis 5/969 26/18722 0.00974927413061431 0.0657415569117295 ZFP36L1/IGF2/SPINT1/SETD2/BMP7 5 GO:0044839 cell cycle G2/M phase transition 15/969 148/18722 0.00984573789054579 0.0659419105730865 APP/PBX1/BRD4/NPM1/USP47/RAB11A/TAOK3/FOXN3/TAOK1/CALM1/CDK1/CALM2/LCMT1/CCNB1/AURKA 15 GO:0070507 regulation of microtubule cytoskeleton organization 15/969 148/18722 0.00984573789054579 0.0659419105730865 AKAP9/CLIP1/MET/DYNC1H1/RPS3/ROCK1/CLTC/TPR/HSPA1A/RHOA/CAMSAP2/TAOK1/HSPA1B/HNRNPU/STMN1 15 GO:1903900 regulation of viral life cycle 15/969 148/18722 0.00984573789054579 0.0659419105730865 DDX5/DDB1/PPIA/PKN2/LY6E/MPHOSPH8/HACD3/LARP1/ADAR/P4HB/PABPC1/KPNA6/BANF1/CAV2/KPNA2 15 GO:0042752 regulation of circadian rhythm 13/969 121/18722 0.00986525766014801 0.0659419105730865 PRKDC/DDB1/ZFHX3/MAGED1/ADRB1/GNAQ/USP9X/KDM2A/THRAP3/SIAH2/NR2F6/CDK1/SFPQ 13 GO:0043244 regulation of protein-containing complex disassembly 13/969 121/18722 0.00986525766014801 0.0659419105730865 IGF1R/SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EIF5A/SETX/UVRAG/EPS8/ADD3 13 GO:0009251 glucan catabolic process 4/969 17/18722 0.00987993034418804 0.0659419105730865 AGL/GAA/RB1CC1/PYGL 4 GO:0048532 anatomical structure arrangement 4/969 17/18722 0.00987993034418804 0.0659419105730865 NRP2/HSPA5/NRP1/TFAP2A 4 GO:0060977 coronary vasculature morphogenesis 4/969 17/18722 0.00987993034418804 0.0659419105730865 LRP2/TGFBR3/NRP1/SETD2 4 GO:0036473 cell death in response to oxidative stress 11/969 95/18722 0.0099230815233265 0.0659771298230334 MET/HSPB1/PPIA/GPX1/PARP1/MCL1/TXN/PAWR/P4HB/REST/SFPQ 11 GO:0042773 ATP synthesis coupled electron transport 11/969 95/18722 0.0099230815233265 0.0659771298230334 COX6A1/UQCRH/COX8C/COX5A/UQCRQ/CDK1/DNAJC15/GHITM/NDUFA6/CCNB1/SDHC 11 GO:0042775 mitochondrial ATP synthesis coupled electron transport 11/969 95/18722 0.0099230815233265 0.0659771298230334 COX6A1/UQCRH/COX8C/COX5A/UQCRQ/CDK1/DNAJC15/GHITM/NDUFA6/CCNB1/SDHC 11 GO:0016574 histone ubiquitination 7/969 47/18722 0.0100117908669681 0.0661461682310688 DDB1/SKP1/HUWE1/UBR5/USP22/WAC/UBE2A 7 GO:0045646 regulation of erythrocyte differentiation 7/969 47/18722 0.0100117908669681 0.0661461682310688 ZFP36L1/PRKDC/CDK6/HSPA1A/MAPK14/HSPA1B/PRMT1 7 GO:0048483 autonomic nervous system development 7/969 47/18722 0.0100117908669681 0.0661461682310688 NRP2/SOX4/NRP1/NF1/TFAP2A/GATA3/HES1 7 GO:1900744 regulation of p38MAPK cascade 7/969 47/18722 0.0100117908669681 0.0661461682310688 GADD45B/DUSP1/DLG1/MAP3K4/EMC10/EZR/PRMT1 7 GO:1903170 negative regulation of calcium ion transmembrane transport 7/969 47/18722 0.0100117908669681 0.0661461682310688 C4orf3/GSTO1/CALM1/YWHAE/VDAC1/CALM2/SRI 7 GO:1901988 negative regulation of cell cycle phase transition 22/969 249/18722 0.0103255613786103 0.0681330603088605 RPL26/ZFP36L1/PRKDC/SOX4/PPP1R10/DUSP1/DLG1/TPR/USP47/CTDSPL/BRD7/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/XPC/CDK1/LCMT1/CCNB1 22 GO:0048678 response to axon injury 10/969 83/18722 0.0104294263011632 0.0686384540828772 LRP1/DAG1/GRN/ISL1/PTPRF/JAM3/MTR/NREP/CDK1/ARF4 10 GO:0050886 endocrine process 10/969 83/18722 0.0104294263011632 0.0686384540828772 GJA1/ENPEP/TBX3/RHOA/TRPV6/MME/TMF1/ATP6AP2/GATA3/KRAS 10 GO:0009411 response to UV 15/969 149/18722 0.0104415558736868 0.0686384540828772 EGFR/RPL26/DDB1/NPM1/GPX1/PARP1/MAP3K4/USP47/PIK3R1/YY1/EP300/EIF2AK4/MME/XPC/UBE2A 15 GO:0030042 actin filament depolymerization 8/969 59/18722 0.010658073542184 0.0699737340847408 CFL1/SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/EPS8/ADD3 8 GO:0001823 mesonephros development 11/969 96/18722 0.0106995527419484 0.0700496244901796 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/SMAD5/BMP7/TACSTD2/GATA3/HES1 11 GO:0034620 cellular response to unfolded protein 11/969 96/18722 0.0106995527419484 0.0700496244901796 HSPA5/PPP1R15A/UFL1/HSPA1A/PIK3R1/CREB3L2/MBTPS1/EP300/XBP1/DDIT3/HSPA1B 11 GO:0032414 positive regulation of ion transmembrane transporter activity 12/969 109/18722 0.010709844999551 0.0700496244901796 TCAF1/AKAP9/GSTO1/ANK3/TMSB4X/KIF5B/SLC9A1/DMD/CALM1/WNK1/ACTN4/CALM2 12 GO:0003208 cardiac ventricle morphogenesis 9/969 71/18722 0.0107234683094817 0.0700510567316893 LRP2/DSP/SOX4/TGFBR3/ISL1/LY6E/JAG1/RBPJ/GATA3 9 GO:0098876 vesicle-mediated transport to the plasma membrane 14/969 136/18722 0.0108827687481991 0.0710029331811343 GOLGA4/KRT18/MACF1/ANK3/KIAA1109/EXOC1/SPTBN1/RAB11A/CLSTN1/VAMP2/GOPC/RAB17/VAMP3/VPS29 14 GO:0032872 regulation of stress-activated MAPK cascade 18/969 192/18722 0.010926091026811 0.0711966978879229 EGFR/APP/GADD45B/PRDX1/DUSP1/DLG1/GSTP1/PPIA/IGF1R/MAP3K4/RB1CC1/NCOR1/TAOK3/TAOK1/CDC42/EMC10/EZR/PRMT1 18 GO:0008406 gonad development 20/969 221/18722 0.0109789872674328 0.0713634172383135 LRP2/HSPA5/SF1/ADGRG1/ATRX/ADAMTS1/NR2F2/EIF2S2/CYP19A1/KDM5A/NRIP1/CTSV/MMP14/ZFX/RHOBTB3/ARID5B/IDH1/CITED2/TMF1/GATA3 20 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 20/969 221/18722 0.0109789872674328 0.0713634172383135 CAV1/RPL11/CTSC/EIF3H/GPX1/UFL1/HECTD1/HSPA1A/DDA1/GNA12/WAC/XPO1/TMEM259/PSME2/TMF1/HSPA1B/CDC20/PSMC1/TAF9/AURKA 20 GO:0031112 positive regulation of microtubule polymerization or depolymerization 6/969 37/18722 0.0111144385143749 0.072154106429967 AKAP9/CLIP1/MET/RPS3/HSPA1A/HSPA1B 6 GO:0061647 histone H3-K9 modification 7/969 48/18722 0.0112115308601587 0.0726941194481261 ATRX/ASH1L/RIF1/ZNF451/JARID2/SETD5/GATA3 7 GO:0031570 DNA integrity checkpoint signaling 13/969 123/18722 0.0112410852380673 0.0727954293112018 RPL26/PRKDC/SOX4/PPP1R10/TAOK3/FOXN3/TAOK1/DDX39B/WAC/MAPK14/EIF2AK4/XPC/CDK1 13 GO:0006112 energy reserve metabolic process 10/969 84/18722 0.0113066990727312 0.0730393193499298 IGF2/AGL/IL6ST/GAA/PTGES3/PHKB/RB1CC1/SORBS1/UGP2/PYGL 10 GO:0032508 DNA duplex unwinding 10/969 84/18722 0.0113066990727312 0.0730393193499298 ATRX/ANXA1/CHD2/RAD50/PURA/CHD4/CHD8/HMGA1/SETX/CHD6 10 GO:0033674 positive regulation of kinase activity 36/969 467/18722 0.0113231634981789 0.0730553733845471 EGFR/DAG1/RPLP1/MET/IQGAP1/IGF2/LMO4/RPS3/EPHB4/EGR1/DLG1/AKAP13/MAGED1/NPM1/PPIA/IGF1R/RANBP2/MAP3K4/PRLR/PPP1R9A/RAD50/ATP2B4/RICTOR/RHOA/TXN/TAOK3/TAOK1/CALM1/WNK1/CKS1B/CDC42/JTB/KRAS/CD24/CALM2/CCNB1 36 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 5/969 27/18722 0.011466122843978 0.0735238748253119 GSTO1/SLC9A1/DMD/CALM1/CALM2 5 GO:0032786 positive regulation of DNA-templated transcription, elongation 5/969 27/18722 0.011466122843978 0.0735238748253119 BRD4/TCERG1/DDX39B/CDK12/SUPT6H 5 GO:0034453 microtubule anchoring 5/969 27/18722 0.011466122843978 0.0735238748253119 DAG1/CEP350/GCC2/PCM1/HOOK3 5 GO:0061437 renal system vasculature development 5/969 27/18722 0.011466122843978 0.0735238748253119 EGR1/NRP1/BMP7/CFLAR/HES1 5 GO:0061440 kidney vasculature development 5/969 27/18722 0.011466122843978 0.0735238748253119 EGR1/NRP1/BMP7/CFLAR/HES1 5 GO:0000302 response to reactive oxygen species 20/969 222/18722 0.0114998911999662 0.0736500384939009 JUN/EGFR/FOS/LDHA/MET/RHOB/RPS3/ANXA1/PRDX1/TRA2B/DUSP1/GSTP1/GPX1/TXN/SOD3/PAWR/BMP7/SETX/CDK1/HMOX1 20 GO:0000086 G2/M transition of mitotic cell cycle 14/969 137/18722 0.0115635826613846 0.0738768740689437 APP/PBX1/BRD4/USP47/RAB11A/TAOK3/FOXN3/TAOK1/CALM1/CDK1/CALM2/LCMT1/CCNB1/AURKA 14 GO:0030879 mammary gland development 14/969 137/18722 0.0115635826613846 0.0738768740689437 CAV1/LRP5/GPX1/PRLR/GLI3/TBX3/KDM5B/ARHGAP5/XBP1/RREB1/ELF3/RTN4/GATA3/LBH 14 GO:1901991 negative regulation of mitotic cell cycle phase transition 17/969 179/18722 0.0116542654847714 0.0743653130933035 RPL26/ZFP36L1/PRKDC/SOX4/DUSP1/DLG1/TPR/USP47/CTDSPL/BRD7/TAOK3/FOXN3/TAOK1/WAC/CDK1/LCMT1/CCNB1 17 GO:0033045 regulation of sister chromatid segregation 9/969 72/18722 0.0117095918745364 0.0745363302513121 DUSP1/TPR/ANAPC11/NEK6/UBE2C/HNRNPU/LCMT1/CCNB1/PTTG1 9 GO:1901880 negative regulation of protein depolymerization 9/969 72/18722 0.0117095918745364 0.0745363302513121 SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EPS8/ADD3 9 GO:0031102 neuron projection regeneration 8/969 60/18722 0.0117560234660354 0.0747408499191009 LRP1/DAG1/GRN/ISL1/PTPRF/JAM3/MTR/NREP 8 GO:0009132 nucleoside diphosphate metabolic process 13/969 124/18722 0.01198254002123 0.0760734913562362 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/DLG1/NCOR1/EP300/PGAM1/PGK1/AK2 13 GO:0051656 establishment of organelle localization 31/969 390/18722 0.0119947487327858 0.0760734913562362 SYNE2/ARMCX3/ITGB1/DYNC1H1/CFL1/GJA1/TRIP11/DLG1/NPM1/ARHGAP21/RAN/KIF5B/PCM1/RAB11A/EML4/RAB6A/CCDC186/KPNB1/ACTN4/XPO1/HOOK3/CDC42/PDCD6/EZR/HMOX1/RAB17/HNRNPU/DYNLT1/NUSAP1/CCNB1/UXT 31 GO:0051052 regulation of DNA metabolic process 29/969 359/18722 0.0120430904088057 0.0762082074318101 EGFR/FUS/ATRX/PRKDC/GJA1/RPS3/PPP1R10/DUSP1/NPM1/RIF1/PARP1/MAP3K4/PTGES3/SETD2/USP9X/RAD50/TFRC/HNRNPA1/MPHOSPH8/SMG1/UBR5/DDX39B/SUPT6H/GATA3/HNRNPC/ANXA3/HNRNPU/CCT8/KPNA2 29 GO:0010959 regulation of metal ion transport 32/969 406/18722 0.0121322976247579 0.0762082074318101 AHNAK/AKAP9/ATP2B1/CAV1/C4orf3/ITGB1/UTRN/GSTO1/GJA1/CD63/ANK3/DLG1/DIAPH1/KIF5B/KCNN4/ATP2B4/PDE4B/SLC9A1/RHOA/LGALS3/DMD/CALM1/WNK1/AHCYL1/ACTN4/HOMER1/VAMP2/CAMK2G/YWHAE/VDAC1/CALM2/SRI 32 GO:0044247 cellular polysaccharide catabolic process 4/969 18/18722 0.0121914595846919 0.0762082074318101 AGL/GAA/RB1CC1/PYGL 4 GO:0048486 parasympathetic nervous system development 4/969 18/18722 0.0121914595846919 0.0762082074318101 NRP2/NRP1/TFAP2A/HES1 4 GO:0097094 craniofacial suture morphogenesis 4/969 18/18722 0.0121914595846919 0.0762082074318101 GLI3/FOXN3/MMP14/TMEM107 4 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 4/969 18/18722 0.0121914595846919 0.0762082074318101 ZFP36L1/TNRC6B/AGO2/PABPC1 4 GO:1901673 regulation of mitotic spindle assembly 4/969 18/18722 0.0121914595846919 0.0762082074318101 TPR/HSPA1A/HSPA1B/HNRNPU 4 GO:1903209 positive regulation of oxidative stress-induced cell death 4/969 18/18722 0.0121914595846919 0.0762082074318101 MCL1/PAWR/REST/SFPQ 4 GO:2000136 regulation of cell proliferation involved in heart morphogenesis 4/969 18/18722 0.0121914595846919 0.0762082074318101 ISL1/TBX3/RBPJ/HES1 4 GO:0032092 positive regulation of protein binding 10/969 85/18722 0.0122386886621709 0.0762082074318101 LRP1/CAV1/APP/RPL11/ANXA2/NRP1/RAN/TCF7L2/EP300/SPPL3 10 GO:0044774 mitotic DNA integrity checkpoint signaling 10/969 85/18722 0.0122386886621709 0.0762082074318101 RPL26/PRKDC/SOX4/PPP1R10/TAOK3/FOXN3/TAOK1/WAC/XPC/CDK1 10 GO:0045069 regulation of viral genome replication 10/969 85/18722 0.0122386886621709 0.0762082074318101 DDX5/DDB1/PPIA/PKN2/MPHOSPH8/HACD3/LARP1/ADAR/PABPC1/BANF1 10 GO:0055013 cardiac muscle cell development 10/969 85/18722 0.0122386886621709 0.0762082074318101 PLEC/ISL1/AKAP13/TBX3/DDX39B/YY1/OBSL1/CDK1/HNRNPU/CCNB1 10 GO:0071277 cellular response to calcium ion 10/969 85/18722 0.0122386886621709 0.0762082074318101 FOS/FUS/JUND/FOSB/HSPA5/IQGAP1/SYT7/JUNB/WNK1/CACYBP 10 GO:0043409 negative regulation of MAPK cascade 17/969 180/18722 0.0122710244566519 0.0762082074318101 CAV1/SEMA6A/DAG1/FBLN1/EIF3A/DUSP6/ASH1L/DUSP1/DLG1/GSTP1/PPIA/IGF1R/NF1/NCOR1/TAOK3/BMP7/EZR 17 GO:0097305 response to alcohol 22/969 253/18722 0.0122770113031583 0.0762082074318101 FOS/ATP2B1/CDH1/FOSB/DAG1/RPL10A/EEF1B2/RPL15/RPL27/TGFBR3/GSTP1/PARP1/RHOA/ABCA1/LARP1/CALM1/DNMT3A/EPS8/CDK1/GATA3/GGH/HPGD 22 GO:0032273 positive regulation of protein polymerization 14/969 138/18722 0.0122771205703192 0.0762082074318101 AKAP9/PFN1/IQGAP2/CLIP1/MET/RPS3/WASF2/ARPC3/DLG1/HSPA1A/SCIN/RICTOR/RHOA/HSPA1B 14 GO:0090288 negative regulation of cellular response to growth factor stimulus 12/969 111/18722 0.0122784750588565 0.0762082074318101 FBN1/LRP2/SEMA6A/CRIM1/ATP2B4/TRIM33/GPC1/CFLAR/HTRA1/EPN2/PDCD6/GATA3 12 GO:0021915 neural tube development 15/969 152/18722 0.0124005339997816 0.0767812673317966 LRP2/PFN1/ZFP36L1/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/GLI3/BMP7/TMEM107/CITED2/ATP6AP2/HES1 15 GO:0051092 positive regulation of NF-kappaB transcription factor activity 15/969 152/18722 0.0124005339997816 0.0767812673317966 CAV1/APP/RPS3/NPM1/PPIA/ERC1/HSPA1A/S100A9/TFRC/RPS6KA5/EP300/CFLAR/FLOT2/HSPA1B/KRAS 15 GO:0034332 adherens junction organization 7/969 49/18722 0.0125120277930612 0.0767812673317966 CDH1/DSP/DLG5/PLEC/JAM3/VCL/CDC42 7 GO:0002002 regulation of angiotensin levels in blood 3/969 10/18722 0.0126125908694293 0.0767812673317966 ENPEP/MME/ATP6AP2 3 GO:0002003 angiotensin maturation 3/969 10/18722 0.0126125908694293 0.0767812673317966 ENPEP/MME/ATP6AP2 3 GO:0010944 negative regulation of transcription by competitive promoter binding 3/969 10/18722 0.0126125908694293 0.0767812673317966 BHLHE41/TFAP2A/KDM2A 3 GO:0031340 positive regulation of vesicle fusion 3/969 10/18722 0.0126125908694293 0.0767812673317966 ANXA1/ANXA2/KIF5B 3 GO:0042989 sequestering of actin monomers 3/969 10/18722 0.0126125908694293 0.0767812673317966 TMSB4X/SCIN/TMSB10 3 GO:0051409 response to nitrosative stress 3/969 10/18722 0.0126125908694293 0.0767812673317966 DUSP6/DDIT3/GCLM 3 GO:0061085 regulation of histone H3-K27 methylation 3/969 10/18722 0.0126125908694293 0.0767812673317966 MTF2/SUPT6H/GATA3 3 GO:0072124 regulation of glomerular mesangial cell proliferation 3/969 10/18722 0.0126125908694293 0.0767812673317966 EGR1/BMP7/CFLAR 3 GO:0098885 modification of postsynaptic actin cytoskeleton 3/969 10/18722 0.0126125908694293 0.0767812673317966 PFN1/MYH10/RHOA 3 GO:1900246 positive regulation of RIG-I signaling pathway 3/969 10/18722 0.0126125908694293 0.0767812673317966 PUM1/ANKRD17/PUM2 3 GO:1903867 extraembryonic membrane development 3/969 10/18722 0.0126125908694293 0.0767812673317966 MAP3K4/BMP7/HTRA1 3 GO:1904668 positive regulation of ubiquitin protein ligase activity 3/969 10/18722 0.0126125908694293 0.0767812673317966 SKP1/UBE2C/CDC20 3 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 3/969 10/18722 0.0126125908694293 0.0767812673317966 ATP2B4/TXN/DMD 3 GO:0032373 positive regulation of sterol transport 6/969 38/18722 0.0126352640461816 0.0767812673317966 LRP1/CAV1/ANXA2/ABCA1/NFKBIA/RXRA 6 GO:0032376 positive regulation of cholesterol transport 6/969 38/18722 0.0126352640461816 0.0767812673317966 LRP1/CAV1/ANXA2/ABCA1/NFKBIA/RXRA 6 GO:0070302 regulation of stress-activated protein kinase signaling cascade 18/969 195/18722 0.0126785985430449 0.0769551172891434 EGFR/APP/GADD45B/PRDX1/DUSP1/DLG1/GSTP1/PPIA/IGF1R/MAP3K4/RB1CC1/NCOR1/TAOK3/TAOK1/CDC42/EMC10/EZR/PRMT1 18 GO:0051403 stress-activated MAPK cascade 21/969 239/18722 0.0127390865023641 0.0772325592359102 EGFR/APP/ZFP36L1/GADD45B/PRDX1/DUSP1/DLG1/GSTP1/PPIA/IGF1R/MAP3K4/RB1CC1/NCOR1/HACD3/TAOK3/TAOK1/MAPK14/CDC42/EMC10/EZR/PRMT1 21 GO:0035924 cellular response to vascular endothelial growth factor stimulus 9/969 73/18722 0.0127618756063886 0.0772810682722907 NRP2/SEMA6A/ANXA1/CD63/HSPB1/NRP1/ATP2B4/GAB1/MAPK14 9 GO:0090342 regulation of cell aging 8/969 61/18722 0.0129349792859798 0.0782386594311695 MIF/PRKDC/CDK6/YBX1/PAWR/HMGA1/NEK6/KRAS 8 GO:0045598 regulation of fat cell differentiation 14/969 139/18722 0.0130243855087316 0.078688368403042 ZFP36L1/LRP5/JAG1/ANKRD26/BMP7/MAPK14/ADIRF/XBP1/RREB1/DDIT3/GATA3/KLF5/HES1/HNRNPU 14 GO:0048640 negative regulation of developmental growth 12/969 112/18722 0.0131260009734342 0.0791193553485205 SEMA6A/SEMA6D/GJA1/NRP1/ADRB1/JARID2/YY1/SLC6A4/VGLL4/CITED2/RTN4/SPAG9 12 GO:1901222 regulation of NIK/NF-kappaB signaling 12/969 112/18722 0.0131260009734342 0.0791193553485205 EGFR/APP/NFAT5/RPS3/PRDX1/TRIM44/TMSB4X/RHOA/BMP7/EP300/ACTN4/NFKBIA 12 GO:0016485 protein processing 20/969 225/18722 0.013181784297115 0.0793640607565932 GLG1/ENO1/ENPEP/PARP1/DHCR24/CTSL/GLI3/CPD/ASPH/PISD/YME1L1/MMP14/PCSK7/MME/SPPL3/ATP6AP2/AFG3L2/STOML2/PGK1/CASP4 20 GO:0035023 regulation of Rho protein signal transduction 10/969 86/18722 0.0132274091169395 0.0795471116744833 ITGB1/MET/KANK1/ADGRG1/AKAP13/NRP1/EPS8L1/ABCA1/EPS8/STMN1 10 GO:0032886 regulation of microtubule-based process 21/969 240/18722 0.0133047339745853 0.0797671721641463 AKAP9/CLIP1/MET/DYNC1H1/MACF1/RPS3/ROCK1/NPM1/CLTC/TPR/HSPA1A/DIAPH1/KLHL42/RHOA/CAMSAP2/TAOK1/XPO1/HSPA1B/HNRNPU/STMN1/AURKA 21 GO:0006165 nucleoside diphosphate phosphorylation 11/969 99/18722 0.0133097922172092 0.0797671721641463 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/PGAM1/PGK1 11 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 11/969 99/18722 0.0133097922172092 0.0797671721641463 TPT1/RPL26/MIF/PRKDC/RPS3/USP47/PIK3R1/MCL1/EP300/HMOX1/TAF9 11 GO:0032801 receptor catabolic process 5/969 28/18722 0.0133776290651011 0.0800818894550039 RNF43/ANXA2/ZNRF3/MYLIP/UVRAG 5 GO:0051495 positive regulation of cytoskeleton organization 20/969 226/18722 0.01378380532036 0.0823256157895555 AKAP9/PFN1/IQGAP2/CLIP1/MET/DYNC1H1/RPS3/S100A10/WASF2/ARPC3/DLG1/NRP1/HSPA1A/SCIN/RICTOR/RHOA/CDC42/HSPA1B/ID1/RHOC 20 GO:0050768 negative regulation of neurogenesis 14/969 140/18722 0.0138063842891805 0.0823256157895555 SEMA6A/SEMA6D/NRP1/NF1/DICER1/PCM1/PRTG/BMP7/RTN4/HOOK3/REST/ID1/HES1/DYNLT1 14 GO:0030856 regulation of epithelial cell differentiation 15/969 154/18722 0.0138581573264877 0.0823256157895555 CAV1/ZFP36L1/ROCK1/NCOA3/BTG1/KIAA1109/TBX3/AHI1/JAG1/VCL/SRSF6/ID1/GATA3/CD24/HES1 15 GO:0030968 endoplasmic reticulum unfolded protein response 9/969 74/18722 0.0138828355473957 0.0823256157895555 HSPA5/PPP1R15A/UFL1/PIK3R1/CREB3L2/MBTPS1/EP300/XBP1/DDIT3 9 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 9/969 74/18722 0.0138828355473957 0.0823256157895555 DDX5/ISL1/UFL1/PARP1/RHOA/NCOR1/FOXP1/EP300/LBH 9 GO:0044843 cell cycle G1/S phase transition 21/969 241/18722 0.0138901524817082 0.0823256157895555 EGFR/RPS6/RPL26/ITGB1/ADAMTS1/PRKDC/BRD4/SOX4/ANXA1/CDK6/DLG1/CTDSPL/ATP2B4/BRD7/EIF4G1/LATS2/ANKRD17/WAC/PSME2/CDKN3/CCNE1 21 GO:0050808 synapse organization 33/969 426/18722 0.0139102678088633 0.0823256157895555 NRP2/CDH1/APP/PFN1/DAG1/MYH10/ACTG1/CFL1/DLG5/WASF2/ANK3/DLG1/NRP1/IGF1R/PTPRF/PPP1R9A/ERC1/EIF4G1/RHOA/PLXNB1/MAPK14/SETD5/PPFIA1/CLSTN1/HOMER1/CDC42/OBSL1/REST/AFG3L2/TPBG/RAB17/ARF4/CDC20 33 GO:0018023 peptidyl-lysine trimethylation 7/969 50/18722 0.0139176413673839 0.0823256157895555 ATRX/BRD4/TET2/SETD2/RTF1/SETD5/IWS1 7 GO:0071709 membrane assembly 7/969 50/18722 0.0139176413673839 0.0823256157895555 CAV1/S100A10/ANK3/ANXA2/SPTBN1/FLOT2/CAV2 7 GO:2000677 regulation of transcription regulatory region DNA binding 7/969 50/18722 0.0139176413673839 0.0823256157895555 TMSB4X/PARP1/NSD1/EP300/DDIT3/GATA3/SRI 7 GO:0090596 sensory organ morphogenesis 22/969 256/18722 0.0139257260539547 0.0823256157895555 FBN1/FBN2/TENM3/TUG1/LRP5/NIPBL/FAT1/GLI3/NF1/EFEMP1/AHI1/MAN2A1/TFAP2A/TRIOBP/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/GATA3/MFAP5 22 GO:0050878 regulation of body fluid levels 30/969 379/18722 0.0140246335041133 0.082723176853833 F5/EGFR/CAV1/MET/ACTG1/FBLN1/LMAN1/GJA1/PLEC/HSPB1/IL6ST/ANXA2/PPIA/PRLR/CLDN4/GNAQ/TLN1/KCNN4/MYL12A/COPA/JMJD1C/GNA12/CLIC1/AKR1B1/VCL/MAPK14/WNK1/XBP1/GJA5/STMN1 30 GO:0051346 negative regulation of hydrolase activity 30/969 379/18722 0.0140246335041133 0.082723176853833 GAPDH/ITIH5/APLP2/LRP1/APP/CRIM1/BOD1L1/SPINT1/ANXA1/SERPINB9/PPP1R15A/ROCK1/ANXA2/GPX1/KDM5A/BIRC6/USP47/DHCR24/AMOT/LGALS3/SERPINB1/WNK1/ARFGEF1/SERPINH1/SIAH2/SERPINB6/CSTB/TIMP2/PTTG1/CNN3 30 GO:0046621 negative regulation of organ growth 6/969 39/18722 0.0142962555791535 0.084040755519298 GJA1/JARID2/YY1/SLC6A4/VGLL4/CITED2 6 GO:0051084 'de novo' posttranslational protein folding 6/969 39/18722 0.0142962555791535 0.084040755519298 HSPA5/PTGES3/HSPA1A/DNAJB1/DNAJB14/HSPA1B 6 GO:0090224 regulation of spindle organization 6/969 39/18722 0.0142962555791535 0.084040755519298 DYNC1H1/CLTC/TPR/HSPA1A/HSPA1B/HNRNPU 6 GO:0031331 positive regulation of cellular catabolic process 33/969 427/18722 0.0143551357174932 0.0842920665838423 LRP2/LRP1/CAV1/APP/KCNQ1OT1/ZFP36L1/CTSC/ROCK1/PUM1/TNRC6B/UFL1/HECTD1/HSPA1A/DDA1/TNRC6A/CELF1/LARP1/WAC/AGO2/RAB3GAP2/VGLL4/TMEM259/BTG2/PABPC1/UVRAG/HSPA1B/EZR/HMOX1/VDAC1/PTTG1IP/CDC20/PSMC1/AURKA 33 GO:0045137 development of primary sexual characteristics 20/969 227/18722 0.0144073603844248 0.0845037770695892 LRP2/HSPA5/SF1/ADGRG1/ATRX/ADAMTS1/NR2F2/EIF2S2/CYP19A1/KDM5A/NRIP1/CTSV/MMP14/ZFX/RHOBTB3/ARID5B/IDH1/CITED2/TMF1/GATA3 20 GO:0035270 endocrine system development 13/969 127/18722 0.0144350474901668 0.0845712535690716 CDH1/PBX1/SOX4/ANXA1/CDK6/ISL1/LY6E/NF1/ARID5B/RBPJ/CITED2/GATA3/HES1 13 GO:0006119 oxidative phosphorylation 14/969 141/18722 0.0146241263553813 0.0853604843089741 COX6A1/UQCRH/COX8C/RHOA/COX5A/UQCRQ/COX7B/CDK1/DNAJC15/GHITM/STOML2/NDUFA6/CCNB1/SDHC 14 GO:0048284 organelle fusion 14/969 141/18722 0.0146241263553813 0.0853604843089741 ANXA1/ANXA2/EEA1/HUWE1/KIF5B/TFRC/SYT7/UVRAG/VAMP2/AFG3L2/CDK1/CAV2/VAMP3/STOML2 14 GO:0010970 transport along microtubule 15/969 155/18722 0.0146350926025336 0.0853604843089741 ARMCX3/APP/DYNC1H1/DST/HSPB1/ARHGAP21/KIF5B/PURA/PCM1/RAB6A/FLOT2/CDC42/SFPQ/HNRNPU/UXT 15 GO:1903364 positive regulation of cellular protein catabolic process 15/969 155/18722 0.0146350926025336 0.0853604843089741 LRP2/LRP1/CAV1/CTSC/HECTD1/HSPA1A/DDA1/VGLL4/TMEM259/HSPA1B/EZR/PTTG1IP/CDC20/PSMC1/AURKA 15 GO:0060065 uterus development 4/969 19/18722 0.0148221835280601 0.0862591660552807 ASH1L/NIPBL/KDM5B/GATA3 4 GO:0061323 cell proliferation involved in heart morphogenesis 4/969 19/18722 0.0148221835280601 0.0862591660552807 ISL1/TBX3/RBPJ/HES1 4 GO:0021987 cerebral cortex development 12/969 114/18722 0.0149543537596123 0.0868349474974823 LRP1/LAMB1/ADGRG1/SLC2A1/TRA2B/TACC2/SLC38A2/GLI3/NF1/RHOA/CELF1/RTN4 12 GO:0022904 respiratory electron transport chain 12/969 114/18722 0.0149543537596123 0.0868349474974823 PLEC/COX6A1/UQCRH/COX8C/COX5A/UQCRQ/CDK1/DNAJC15/GHITM/NDUFA6/CCNB1/SDHC 12 GO:0006278 RNA-dependent DNA biosynthetic process 9/969 75/18722 0.0150749675481491 0.0874381580539705 MAP3K4/PTGES3/RAD50/HNRNPA1/HNRNPC/HNRNPU/NHP2/CCT8/NOP10 9 GO:0016358 dendrite development 21/969 243/18722 0.015122148212415 0.0876145748980943 APP/ITGB1/IQGAP1/CFL1/DLG5/CUX1/RERE/NRP1/KIDINS220/PPP1R9A/RHOA/CAMSAP2/BMP7/CDC42/OBSL1/ID1/TPBG/RAB17/DYNLT1/ARF4/CDC20 21 GO:0046939 nucleotide phosphorylation 11/969 101/18722 0.0153004324469882 0.0884513937698677 GAPDH/ALDOA/LDHA/APP/TPI1/PKM/ENO1/NCOR1/EP300/PGAM1/PGK1 11 GO:0098869 cellular oxidant detoxification 11/969 101/18722 0.0153004324469882 0.0884513937698677 GPX3/GSTO1/PRDX6/PRDX1/GPX4/GSTP1/GPX1/S100A9/TXN/SOD3/BMP7 11 GO:0032873 negative regulation of stress-activated MAPK cascade 7/969 51/18722 0.0154326356466922 0.0885831002962922 DUSP1/DLG1/GSTP1/PPIA/NCOR1/TAOK3/EZR 7 GO:0045661 regulation of myoblast differentiation 7/969 51/18722 0.0154326356466922 0.0885831002962922 ZFP36L1/BTG1/MBNL3/TBX3/MAPK14/DDIT3/FLOT2 7 GO:0051293 establishment of spindle localization 7/969 51/18722 0.0154326356466922 0.0885831002962922 ITGB1/DYNC1H1/CFL1/GJA1/KPNB1/DYNLT1/NUSAP1 7 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 7/969 51/18722 0.0154326356466922 0.0885831002962922 DUSP1/DLG1/GSTP1/PPIA/NCOR1/TAOK3/EZR 7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 5/969 29/18722 0.0154927197992367 0.0885831002962922 TNRC6B/TNRC6A/AGO2/BTG2/PABPC1 5 GO:0021602 cranial nerve morphogenesis 5/969 29/18722 0.0154927197992367 0.0885831002962922 NRP2/NRP1/GLI3/TFAP2A/CITED2 5 GO:0022011 myelination in peripheral nervous system 5/969 29/18722 0.0154927197992367 0.0885831002962922 ITGB4/DAG1/PLEC/NF1/DICER1 5 GO:0032292 peripheral nervous system axon ensheathment 5/969 29/18722 0.0154927197992367 0.0885831002962922 ITGB4/DAG1/PLEC/NF1/DICER1 5 GO:0034067 protein localization to Golgi apparatus 5/969 29/18722 0.0154927197992367 0.0885831002962922 GCC2/VPS13C/VPS13A/RAB6A/OBSL1 5 GO:1903902 positive regulation of viral life cycle 5/969 29/18722 0.0154927197992367 0.0885831002962922 DDB1/P4HB/KPNA6/CAV2/KPNA2 5 GO:0030239 myofibril assembly 8/969 63/18722 0.0155488139814468 0.0886129791352681 KRT19/KRT8/ITGB1/ACTG1/PLEC/AKAP13/CFLAR/OBSL1 8 GO:0050854 regulation of antigen receptor-mediated signaling pathway 8/969 63/18722 0.0155488139814468 0.0886129791352681 SLC39A10/RPS3/PHPT1/KCNN4/FOXP1/LGALS3/PAWR/EZR 8 GO:1902373 negative regulation of mRNA catabolic process 8/969 63/18722 0.0155488139814468 0.0886129791352681 FUS/YBX1/LARP1/MAPK14/THRAP3/PABPC1/HNRNPC/HNRNPU 8 GO:0009416 response to light stimulus 26/969 320/18722 0.0156874876171801 0.089305893559241 EGFR/FOS/JUND/RPL26/APP/ITGB1/DDB1/DUSP1/NPM1/DYNLRB1/GPX1/PARP1/MAP3K4/USP47/GNAQ/NF1/PIK3R1/YY1/NMT1/EP300/EIF2AK4/MME/NR2F6/XPC/KRAS/UBE2A 26 GO:0051271 negative regulation of cellular component movement 29/969 367/18722 0.0158585009220493 0.0901812032846894 TCAF1/LRP1/CDH1/MIF/DAG1/FBLN1/RHOB/KANK1/ADGRG1/DLG5/SEMA6D/GJA1/NR2F2/TGFBR3/DUSP1/MIA3/GSTP1/NF1/ATP2B4/CSNK2B/RHOA/GNA12/JAG1/VCL/CITED2/DPP4/TACSTD2/GATA3/HMOX1 29 GO:0071902 positive regulation of protein serine/threonine kinase activity 18/969 200/18722 0.0160846467430807 0.0909793252870019 EGFR/IQGAP1/IGF2/RPS3/AKAP13/MAGED1/MAP3K4/ATP2B4/RICTOR/RHOA/TAOK3/TAOK1/CALM1/CKS1B/KRAS/CD24/CALM2/CCNB1 18 GO:0030866 cortical actin cytoskeleton organization 6/969 40/18722 0.0161033057578409 0.0909793252870019 PLEC/DLG1/ROCK1/FMNL2/TLN1/EZR 6 GO:0044275 cellular carbohydrate catabolic process 6/969 40/18722 0.0161033057578409 0.0909793252870019 TPI1/AGL/GAA/RB1CC1/PYGL/PGAM1 6 GO:0060412 ventricular septum morphogenesis 6/969 40/18722 0.0161033057578409 0.0909793252870019 SOX4/TGFBR3/TBX3/RBPJ/CITED2/HES1 6 GO:0071526 semaphorin-plexin signaling pathway 6/969 40/18722 0.0161033057578409 0.0909793252870019 NRP2/SEMA6A/MET/SEMA6D/NRP1/PLXNB1 6 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 6/969 40/18722 0.0161033057578409 0.0909793252870019 C4orf3/GSTO1/CALM1/YWHAE/CALM2/SRI 6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 9/969 76/18722 0.0163407410848467 0.0921215888990385 RPL26/MIF/RPL11/DDX5/PMAIP1/EIF5A/EP300/PTTG1IP/TAF9 9 GO:0140115 export across plasma membrane 9/969 76/18722 0.0163407410848467 0.0921215888990385 ATP2B1/GJA1/DLG1/SLC9A1/ABCA1/SLC40A1/CALM1/YWHAE/CALM2 9 GO:0003139 secondary heart field specification 3/969 11/18722 0.0166838477558654 0.0924600088782108 LRP2/ISL1/RBPJ 3 GO:0019372 lipoxygenase pathway 3/969 11/18722 0.0166838477558654 0.0924600088782108 GPX4/GPX1/HPGD 3 GO:0035404 histone-serine phosphorylation 3/969 11/18722 0.0166838477558654 0.0924600088782108 RPS6KA5/CCNB1/AURKA 3 GO:0036490 regulation of translation in response to endoplasmic reticulum stress 3/969 11/18722 0.0166838477558654 0.0924600088782108 PPP1R15A/EIF4G1/EIF2AK4 3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 3/969 11/18722 0.0166838477558654 0.0924600088782108 EPAS1/CHD6/HMOX1 3 GO:0051657 maintenance of organelle location 3/969 11/18722 0.0166838477558654 0.0924600088782108 AKAP9/ARHGAP21/UVRAG 3 GO:0060379 cardiac muscle cell myoblast differentiation 3/969 11/18722 0.0166838477558654 0.0924600088782108 ISL1/RBPJ/REST 3 GO:0061314 Notch signaling involved in heart development 3/969 11/18722 0.0166838477558654 0.0924600088782108 GALNT11/JAG1/RBPJ 3 GO:0070417 cellular response to cold 3/969 11/18722 0.0166838477558654 0.0924600088782108 SLC9A1/EIF2AK4/NFKBIA 3 GO:0071679 commissural neuron axon guidance 3/969 11/18722 0.0166838477558654 0.0924600088782108 DAG1/NRP1/NFIB 3 GO:0072110 glomerular mesangial cell proliferation 3/969 11/18722 0.0166838477558654 0.0924600088782108 EGR1/BMP7/CFLAR 3 GO:0072497 mesenchymal stem cell differentiation 3/969 11/18722 0.0166838477558654 0.0924600088782108 KRT18/LTBP3/REST 3 GO:0075733 intracellular transport of virus 3/969 11/18722 0.0166838477558654 0.0924600088782108 KPNA6/DYNLT1/KPNA2 3 GO:0090084 negative regulation of inclusion body assembly 3/969 11/18722 0.0166838477558654 0.0924600088782108 HSPA1A/DNAJB1/HSPA1B 3 GO:1902915 negative regulation of protein polyubiquitination 3/969 11/18722 0.0166838477558654 0.0924600088782108 TRIM44/PPIA/UBR5 3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 3/969 11/18722 0.0166838477558654 0.0924600088782108 HSPA1A/HSPA1B/CASP4 3 GO:0006473 protein acetylation 18/969 201/18722 0.016844206294151 0.0931003722099991 SOX4/ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/TAOK1/PHF20L1/EP300/PHF14/SETD5/PHF20/EID1/GATA3/IWS1/TAF9 18 GO:0009952 anterior/posterior pattern specification 18/969 201/18722 0.016844206294151 0.0931003722099991 BPTF/PBX1/WLS/PRKDC/NR2F2/LRP5/PGAP1/GLI3/TBX3/BHLHE41/YY1/EP300/RBPJ/BTG2/DDIT3/ATP6AP2/HES1/AURKA 18 GO:0043010 camera-type eye development 26/969 322/18722 0.0168528419653003 0.0931003722099991 FBN1/FBN2/ATP2B1/RPL24/TENM3/DLG1/LRP5/NRP1/CRYBG3/FAT1/GLI3/NF1/KDM5B/EFEMP1/ATP2B4/AHI1/MAN2A1/TFAP2A/JAG1/YY1/BMP7/NAGLU/CITED2/OBSL1/GATA3/IMPDH2 26 GO:0007219 Notch signaling pathway 16/969 172/18722 0.016899906525002 0.0931634087549163 KRT19/CD46/AAK1/APP/IL6ST/GALNT11/MAML2/ANXA4/SEL1L/JAG1/MMP14/BMP7/RBPJ/EPN2/NFKBIA/HES1 16 GO:1990138 neuron projection extension 16/969 172/18722 0.016899906525002 0.0931634087549163 NRP2/LRP1/GOLGA4/SEMA6A/ITGB1/MACF1/IQGAP1/SEMA6D/NRP1/USP9X/RAB11A/VCL/EIF2AK4/RTN4/SPAG9/AURKA 16 GO:0035967 cellular response to topologically incorrect protein 12/969 116/18722 0.0169696009009501 0.0933647216132993 HSPA5/PPP1R15A/UFL1/HSPA1A/PIK3R1/DNAJB14/CREB3L2/MBTPS1/EP300/XBP1/DDIT3/HSPA1B 12 GO:0045995 regulation of embryonic development 8/969 64/18722 0.0169900210972537 0.0933647216132993 DAG1/LAMA5/CFL1/NIPBL/AMOT/B4GALT5/CDK1/HES1 8 GO:0055002 striated muscle cell development 8/969 64/18722 0.0169900210972537 0.0933647216132993 KRT19/KRT8/ITGB1/ACTG1/PLEC/AKAP13/CFLAR/OBSL1 8 GO:0018209 peptidyl-serine modification 27/969 338/18722 0.0171259042075776 0.0940125791899163 EGFR/AKAP9/CAV1/APP/MIF/PRKDC/ROCK1/PARP1/PKN2/TFRC/ATP2B4/RICTOR/EIF4G1/RPS6KA5/NSD1/LATS2/SMG1/TXN/DMD/MAST4/MAPK14/WNK1/NEK6/GALNT1/CDK1/CCNB1/AURKA 27 GO:0045639 positive regulation of myeloid cell differentiation 11/969 103/18722 0.0175067520585818 0.0960023990116984 JUN/FOS/ZFP36L1/PRKDC/HSPA1A/SCIN/RCOR1/JAG1/MAPK14/HSPA1B/PRMT1 11 GO:0031016 pancreas development 9/969 77/18722 0.0176825931289079 0.0962042760944885 MET/WLS/IGF2/SOX4/ANXA1/CDK6/ISL1/TCF7L2/HES1 9 GO:0007409 axonogenesis 32/969 418/18722 0.0177826193987134 0.0962042760944885 NRP2/LRP1/GOLGA4/RPL24/SEMA6A/APP/DAG1/LAMA5/ITGB1/MYCBP2/MACF1/SEMA6D/EPHB4/ANK3/ISL1/NRP1/KIF5B/USP9X/GLI3/RAB11A/RPS6KA5/PLXNB1/NFIB/VCL/SIAH1/BMP7/B4GALT5/B3GNT2/RTN4/AFG3L2/GATA3/STMN1 32 GO:0000272 polysaccharide catabolic process 4/969 20/18722 0.0177849830951143 0.0962042760944885 AGL/GAA/RB1CC1/PYGL 4 GO:0003215 cardiac right ventricle morphogenesis 4/969 20/18722 0.0177849830951143 0.0962042760944885 SOX4/ISL1/JAG1/GATA3 4 GO:0006607 NLS-bearing protein import into nucleus 4/969 20/18722 0.0177849830951143 0.0962042760944885 RANBP2/KPNB1/KPNA6/KPNA2 4 GO:0006700 C21-steroid hormone biosynthetic process 4/969 20/18722 0.0177849830951143 0.0962042760944885 CYP11A1/EGR1/AKR1B1/REST 4 GO:0010523 negative regulation of calcium ion transport into cytosol 4/969 20/18722 0.0177849830951143 0.0962042760944885 GSTO1/CALM1/CALM2/SRI 4 GO:0043555 regulation of translation in response to stress 4/969 20/18722 0.0177849830951143 0.0962042760944885 PPP1R15A/NPM1/EIF4G1/EIF2AK4 4 GO:0048025 negative regulation of mRNA splicing, via spliceosome 4/969 20/18722 0.0177849830951143 0.0962042760944885 NPM1/SRSF7/SAP18/SRSF6 4 GO:0060044 negative regulation of cardiac muscle cell proliferation 4/969 20/18722 0.0177849830951143 0.0962042760944885 GJA1/JARID2/VGLL4/CITED2 4 GO:0071243 cellular response to arsenic-containing substance 4/969 20/18722 0.0177849830951143 0.0962042760944885 GSTO1/SLC38A2/HNRNPA1/HMOX1 4 GO:0002028 regulation of sodium ion transport 10/969 90/18722 0.017789576859505 0.0962042760944885 UTRN/ANK3/DLG1/KIF5B/ATP2B4/SLC9A1/DMD/WNK1/AHCYL1/ACTN4 10 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 5/969 30/18722 0.0178196975238165 0.0962042760944885 GSTO1/DMD/CALM1/CALM2/SRI 5 GO:0140058 neuron projection arborization 5/969 30/18722 0.0178196975238165 0.0962042760944885 LRP2/MACF1/ROCK1/NRP1/TPBG 5 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 5/969 30/18722 0.0178196975238165 0.0962042760944885 HSPA5/PPP1R15A/UFL1/PIK3R1/XBP1 5 GO:0010594 regulation of endothelial cell migration 20/969 232/18722 0.0178659708368806 0.0963545547920929 NRP2/MET/RHOB/GRN/ANXA1/NR2F2/HSPB1/PLPP3/NRP1/TMSB4X/NF1/ATP2B4/CSNK2B/RHOA/FOXP1/PDCD6/EMC10/GATA3/HMOX1/ANXA3 20 GO:0031062 positive regulation of histone methylation 6/969 41/18722 0.0180620512036429 0.0970115925901724 BRD4/RIF1/JARID2/PAXBP1/MTF2/RTF1 6 GO:0050856 regulation of T cell receptor signaling pathway 6/969 41/18722 0.0180620512036429 0.0970115925901724 RPS3/PHPT1/KCNN4/LGALS3/PAWR/EZR 6 GO:0055023 positive regulation of cardiac muscle tissue growth 6/969 41/18722 0.0180620512036429 0.0970115925901724 TGFBR3/DDX39B/MAPK14/RBPJ/CDK1/CCNB1 6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 6/969 41/18722 0.0180620512036429 0.0970115925901724 S100A10/NRP1/TRIOBP/P4HB/RREB1/CDC42 6 GO:0007159 leukocyte cell-cell adhesion 29/969 371/18722 0.0180995046546274 0.0971129479723642 CAV1/CD46/ITGB1/NFAT5/IGF2/DLG5/RPS3/SOX4/ANXA1/IL6ST/DOCK8/DLG1/ROCK1/MIA3/GLI3/S100A9/TFRC/RHOA/LGALS3/PAWR/BMP7/WNK1/XBP1/FLOT2/DPP4/GATA3/CD24/EZR/HES1 29 GO:0051961 negative regulation of nervous system development 14/969 145/18722 0.0182727423956426 0.0979418992406442 SEMA6A/SEMA6D/NRP1/NF1/DICER1/PCM1/PRTG/BMP7/RTN4/HOOK3/REST/ID1/HES1/DYNLT1 14 GO:0003170 heart valve development 8/969 65/18722 0.0185248715908286 0.0989887310160227 SOX4/ROCK1/HECTD1/JAG1/MDM4/GJA5/RBPJ/GATA3 8 GO:0010965 regulation of mitotic sister chromatid separation 8/969 65/18722 0.0185248715908286 0.0989887310160227 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1/PTTG1 8 GO:0043489 RNA stabilization 8/969 65/18722 0.0185248715908286 0.0989887310160227 FUS/YBX1/LARP1/MAPK14/THRAP3/PABPC1/HNRNPC/HNRNPU 8 GO:0048639 positive regulation of developmental growth 16/969 174/18722 0.0186555673086972 0.0995852857561303 LRP1/GOLGA4/MACF1/IGF2/PRKDC/TGFBR3/NRP1/NIPBL/RAB11A/CELF1/DDX39B/MAPK14/RBPJ/CDK1/EZR/CCNB1 16 GO:0006892 post-Golgi vesicle-mediated transport 11/969 104/18722 0.0186948445087084 0.0996931197984798 GOLGA4/KRT18/MACF1/ANK3/VPS13C/EXOC1/SPTBN1/VPS13A/VAMP2/GOPC/VAMP3 11 GO:0007566 embryo implantation 7/969 53/18722 0.0188072499819728 0.0998848459408435 ITGB4/RPL29/FBLN1/GJA1/PRLR/AGO2/STC2 7 GO:0051438 regulation of ubiquitin-protein transferase activity 7/969 53/18722 0.0188072499819728 0.0998848459408435 RPS2/RPL11/RPS20/SKP1/UBE2C/UBE2L3/CDC20 7 GO:1990090 cellular response to nerve growth factor stimulus 7/969 53/18722 0.0188072499819728 0.0998848459408435 APP/HSPA5/BPTF/ARPC3/KIDINS220/USP8/ID1 7 GO:2000772 regulation of cellular senescence 7/969 53/18722 0.0188072499819728 0.0998848459408435 PRKDC/CDK6/YBX1/PAWR/HMGA1/NEK6/KRAS 7 GO:0042147 retrograde transport, endosome to Golgi 10/969 91/18722 0.0190918007000032 0.101249361915866 CLTC/GCC2/ERC1/TMEM87A/RAB6A/RHOBTB3/EVI5/SPAG9/VAMP3/VPS29 10 GO:0032024 positive regulation of insulin secretion 9/969 78/18722 0.0191029220912829 0.101249361915866 LRP1/DYNLL1/GJA1/SOX4/ISL1/PHPT1/KIF5B/TCF7L2/SRI 9 GO:1904062 regulation of cation transmembrane transport 28/969 357/18722 0.0191685915083505 0.101466207626171 AHNAK/AKAP9/CAV1/APP/C4orf3/ITGB1/UTRN/GSTO1/CD63/ANK3/DLG1/TMSB4X/DIAPH1/KIF5B/KCNN4/ATP2B4/PDE4B/SLC9A1/DMD/CALM1/WNK1/ACTN4/HOMER1/VAMP2/YWHAE/VDAC1/CALM2/SRI 28 GO:0045446 endothelial cell differentiation 12/969 118/18722 0.0191826661183806 0.101466207626171 MET/NR2F2/ROCK1/NRP1/GPX1/BTG1/JAG1/VCL/RBPJ/EDF1/ID1/EZR 12 GO:0046879 hormone secretion 24/969 295/18722 0.0194172985814765 0.102503725659966 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/CYP19A1/PHPT1/KIF5B/TBX3/KDM5B/SYT7/CCDC186/TCF7L2/TRPV6/HMGN3/DPP4/TMF1/REST/CAMK2G/GATA3/SRI 24 GO:0048588 developmental cell growth 20/969 234/18722 0.0194180421743907 0.102503725659966 NRP2/LRP1/GOLGA4/SEMA6A/APP/ITGB1/MACF1/IQGAP1/SEMA6D/AKAP13/NRP1/USP9X/RAB11A/DDX39B/YY1/VCL/EIF2AK4/RTN4/SPAG9/AURKA 20 GO:0048771 tissue remodeling 16/969 175/18722 0.0195841444020122 0.103276224666918 EGFR/CAV1/GJA1/LGR4/ROCK1/LRP5/SUCO/NF1/TFRC/EPAS1/SYT7/JAG1/MMP14/LTBP3/RBPJ/ELF3 16 GO:0001933 negative regulation of protein phosphorylation 27/969 342/18722 0.0196269945728215 0.103397856489481 LRP1/CAV1/FBLN1/GADD45B/PRKDC/NR2F2/PLEC/DUSP6/HSPB1/PLPP3/DUSP1/NPM1/GSTP1/LRP5/PPIA/GNAQ/NF1/CTDSPL/EIF4G1/LATS2/DMD/CALM1/ADAR/BMP7/SPAG9/CALM2/CCNB1 27 GO:0014015 positive regulation of gliogenesis 8/969 66/18722 0.0201563628049329 0.106079709988499 EGFR/LRP2/DAG1/SPINT1/IL6ST/UFL1/DICER1/HES1 8 GO:0045214 sarcomere organization 6/969 42/18722 0.0201778478897552 0.106085948764447 KRT19/KRT8/ITGB1/ACTG1/PLEC/AKAP13 6 GO:0002064 epithelial cell development 19/969 220/18722 0.0202513055264058 0.106118322484898 ADAMTSL4/MET/ATRX/IQGAP1/PLEC/CDK6/IL6ST/ROCK1/GPX1/FAT1/EXPH5/TRIOBP/JAG1/AKR1B1/VCL/TFCP2L1/KLF5/EZR/RAB25 19 GO:0048705 skeletal system morphogenesis 19/969 220/18722 0.0202513055264058 0.106118322484898 FBN2/GLG1/ANKRD11/TRIP11/DLG1/LRP5/NIPBL/SETD2/GLI3/TFAP2A/FOXN3/MMP14/LTBP3/BMP7/MAPK14/TMEM107/ARID5B/CITED2/SERPINH1 19 GO:0016331 morphogenesis of embryonic epithelium 14/969 147/18722 0.020337749432413 0.106118322484898 LRP2/PFN1/LAMA5/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/IRX2/TFAP2A/BMP7/CITED2/GATA3 14 GO:0016577 histone demethylation 5/969 31/18722 0.0203662000033644 0.106118322484898 KDM5A/KDM5B/JARID2/JMJD1C/KDM2A 5 GO:0051443 positive regulation of ubiquitin-protein transferase activity 5/969 31/18722 0.0203662000033644 0.106118322484898 RPS2/SKP1/UBE2C/UBE2L3/CDC20 5 GO:0055022 negative regulation of cardiac muscle tissue growth 5/969 31/18722 0.0203662000033644 0.106118322484898 GJA1/JARID2/YY1/VGLL4/CITED2 5 GO:0060045 positive regulation of cardiac muscle cell proliferation 5/969 31/18722 0.0203662000033644 0.106118322484898 TGFBR3/MAPK14/RBPJ/CDK1/CCNB1 5 GO:0061117 negative regulation of heart growth 5/969 31/18722 0.0203662000033644 0.106118322484898 GJA1/JARID2/YY1/VGLL4/CITED2 5 GO:0031398 positive regulation of protein ubiquitination 12/969 119/18722 0.020366758027622 0.106118322484898 CAV1/HSPA5/RPS2/MYCBP2/NPM1/SKP1/HUWE1/UBE2C/UBE2L3/PDCD6/PTTG1IP/CDC20 12 GO:0098813 nuclear chromosome segregation 23/969 281/18722 0.0204530039917728 0.106421544102414 DYNC1H1/ATRX/DUSP1/NIPBL/TPR/RAN/RAB11A/ANAPC11/PDS5A/EML4/KPNB1/NEK6/UBE2C/STAG1/CDC42/SFPQ/HNRNPU/LCMT1/NUSAP1/CDC20/CCNB1/PTTG1/CCNE1 23 GO:2000146 negative regulation of cell motility 28/969 359/18722 0.0204656815581566 0.106421544102414 TCAF1/LRP1/CDH1/MIF/DAG1/FBLN1/RHOB/KANK1/ADGRG1/DLG5/SEMA6D/GJA1/NR2F2/DUSP1/MIA3/GSTP1/NF1/ATP2B4/CSNK2B/RHOA/GNA12/JAG1/VCL/CITED2/DPP4/TACSTD2/GATA3/HMOX1 28 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 9/969 79/18722 0.0206040818630285 0.106870825104142 PRKDC/CUX1/S100A10/NRP1/TRIOBP/P4HB/RREB1/CDC42/OBSL1 9 GO:0040013 negative regulation of locomotion 30/969 391/18722 0.0206580872045744 0.106870825104142 TCAF1/LRP1/CDH1/SEMA6A/MIF/DAG1/FBLN1/RHOB/KANK1/ADGRG1/DLG5/SEMA6D/GJA1/NR2F2/DUSP1/MIA3/GSTP1/NRP1/NF1/ATP2B4/CSNK2B/RHOA/GNA12/JAG1/VCL/CITED2/DPP4/TACSTD2/GATA3/HMOX1 30 GO:0030520 intracellular estrogen receptor signaling pathway 7/969 54/18722 0.0206747807463236 0.106870825104142 DDX5/DDX17/ISL1/UFL1/PARP1/ARID1A/LBH 7 GO:0030834 regulation of actin filament depolymerization 7/969 54/18722 0.0206747807463236 0.106870825104142 SCIN/SPTBN1/SPTAN1/SVIL/TRIOBP/EPS8/ADD3 7 GO:0072698 protein localization to microtubule cytoskeleton 7/969 54/18722 0.0206747807463236 0.106870825104142 GOLGB1/CEP350/DIAPH1/PCM1/HOOK3/HNRNPU/AURKA 7 GO:0086002 cardiac muscle cell action potential involved in contraction 7/969 54/18722 0.0206747807463236 0.106870825104142 CAV1/DSP/GJA1/DLG1/DSG2/DSC2/GJA5 7 GO:0034250 positive regulation of cellular amide metabolic process 15/969 162/18722 0.0210543380472179 0.108271501074812 RPL26/RPS4X/PRKDC/PKM/SOX4/PPP1R15A/NPM1/EIF4G1/RHOA/LARP1/DDX39B/EIF5A/AGO2/EIF2AK4/PABPC1 15 GO:0038083 peptidyl-tyrosine autophosphorylation 4/969 21/18722 0.0210907746066129 0.108271501074812 EGFR/CAV1/IQGAP1/IGF1R 4 GO:0045655 regulation of monocyte differentiation 4/969 21/18722 0.0210907746066129 0.108271501074812 JUN/ZFP36L1/CDK6/FOXP1 4 GO:0060445 branching involved in salivary gland morphogenesis 4/969 21/18722 0.0210907746066129 0.108271501074812 DAG1/LAMA5/NRP1/BMP7 4 GO:0072111 cell proliferation involved in kidney development 4/969 21/18722 0.0210907746066129 0.108271501074812 EGR1/BMP7/CFLAR/GATA3 4 GO:0150105 protein localization to cell-cell junction 4/969 21/18722 0.0210907746066129 0.108271501074812 ACTG1/DSP/DLG5/VCL 4 GO:2000178 negative regulation of neural precursor cell proliferation 4/969 21/18722 0.0210907746066129 0.108271501074812 SPINT1/NF1/SLC6A4/BTG2 4 GO:0002328 pro-B cell differentiation 3/969 12/18722 0.0214029315268372 0.109017271110382 PRKDC/SOX4/HES1 3 GO:0009886 post-embryonic animal morphogenesis 3/969 12/18722 0.0214029315268372 0.109017271110382 FBN1/ATRX/EFEMP1 3 GO:0021559 trigeminal nerve development 3/969 12/18722 0.0214029315268372 0.109017271110382 ISL1/NRP1/TFAP2A 3 GO:0034333 adherens junction assembly 3/969 12/18722 0.0214029315268372 0.109017271110382 DLG5/JAM3/VCL 3 GO:0060019 radial glial cell differentiation 3/969 12/18722 0.0214029315268372 0.109017271110382 GLI3/RHOA/HES1 3 GO:0071472 cellular response to salt stress 3/969 12/18722 0.0214029315268372 0.109017271110382 ZFP36L1/AKR1B1/EFHD1 3 GO:0071872 cellular response to epinephrine stimulus 3/969 12/18722 0.0214029315268372 0.109017271110382 ATP2B4/PDE4B/SLC9A1 3 GO:0098974 postsynaptic actin cytoskeleton organization 3/969 12/18722 0.0214029315268372 0.109017271110382 ACTG1/WASF2/PPP1R9A 3 GO:0010212 response to ionizing radiation 14/969 148/18722 0.0214339297427573 0.109068857678335 RPL26/HSPA5/RHOB/PRKDC/ANXA1/EGR1/GPX1/PARP1/NIPBL/XRRA1/DNMT3A/MAPK14/EEF1D/GATA3 14 GO:0051302 regulation of cell division 16/969 177/18722 0.0215466766286647 0.109535926129768 IGF2/NCOA3/PKN2/BIRC6/YBX1/SETD2/RAB11A/RHOA/PRPF40A/SVIL/CALM1/CDC42/UVRAG/LBH/CALM2/AURKA 16 GO:0048675 axon extension 12/969 120/18722 0.0216043341124362 0.109722303276571 NRP2/LRP1/GOLGA4/SEMA6A/ITGB1/MACF1/SEMA6D/NRP1/USP9X/RAB11A/VCL/RTN4 12 GO:0051306 mitotic sister chromatid separation 8/969 67/18722 0.021887409157282 0.110705042185543 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1/PTTG1 8 GO:0061180 mammary gland epithelium development 8/969 67/18722 0.021887409157282 0.110705042185543 LRP5/GPX1/TBX3/KDM5B/RREB1/RTN4/GATA3/LBH 8 GO:0070527 platelet aggregation 8/969 67/18722 0.021887409157282 0.110705042185543 ACTG1/HSPB1/IL6ST/PPIA/TLN1/MYL12A/CLIC1/VCL 8 GO:0051591 response to cAMP 10/969 93/18722 0.0219037530845486 0.110705042185543 JUN/AKAP9/FOS/LDHA/FOSB/APP/HSPA5/ZFP36L1/DUSP1/EZR 10 GO:1901019 regulation of calcium ion transmembrane transporter activity 10/969 93/18722 0.0219037530845486 0.110705042185543 AHNAK/C4orf3/GSTO1/PDE4B/SLC9A1/DMD/CALM1/YWHAE/CALM2/SRI 10 GO:0031334 positive regulation of protein-containing complex assembly 20/969 237/18722 0.0219396862076783 0.110779517025436 AKAP9/PFN1/IQGAP2/CLIP1/MET/RPS3/WASF2/ARPC3/DLG1/HSPA1A/FERMT1/SCIN/TFRC/RICTOR/EIF4G1/RHOA/ABCA1/LGALS3/HSPA1B/RHOC 20 GO:0010976 positive regulation of neuron projection development 15/969 163/18722 0.0221220332134238 0.111484807688865 LRP1/ITGA6/TENM3/HSPA5/GRN/IQGAP1/KIDINS220/PPP1R9A/S100A9/CREB3L2/BMP7/EP300/SETX/CFLAR/DYNLT1 15 GO:0071322 cellular response to carbohydrate stimulus 15/969 163/18722 0.0221220332134238 0.111484807688865 LRP1/DYNLL1/ZFP36L1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/CCDC186/COLEC12/XBP1/HMGN3/GCLM/SRI 15 GO:0048145 regulation of fibroblast proliferation 9/969 80/18722 0.0221883759727828 0.111711418914993 FTH1/MIF/PRKDC/CDK6/ANXA2/GSTP1/NF1/PAWR/CCNB1 9 GO:0006458 'de novo' protein folding 6/969 43/18722 0.0224557487163217 0.112623553542704 HSPA5/PTGES3/HSPA1A/DNAJB1/DNAJB14/HSPA1B 6 GO:0010171 body morphogenesis 6/969 43/18722 0.0224557487163217 0.112623553542704 DAG1/ANKRD11/NIPBL/EP300/ARID5B/ATP6AP2 6 GO:0045840 positive regulation of mitotic nuclear division 6/969 43/18722 0.0224557487163217 0.112623553542704 IGF2/LRP5/PHIP/ANAPC11/NUSAP1/AURKA 6 GO:0060443 mammary gland morphogenesis 6/969 43/18722 0.0224557487163217 0.112623553542704 CAV1/LRP5/GLI3/TBX3/KDM5B/ELF3 6 GO:0009266 response to temperature stimulus 16/969 178/18722 0.0225821764237032 0.113149045052994 FOS/ATP2B1/ADRB1/TPR/HSPA1A/SLC9A1/DNAJB1/SLC52A3/EP300/EIF2AK4/NFKBIA/NR2F6/PDCD6/HSPA1B/HMOX1/YWHAE 16 GO:0001755 neural crest cell migration 7/969 55/18722 0.0226674854912237 0.113359118829794 NRP2/SEMA6A/LAMA5/SEMA6D/ISL1/NRP1/BMP7 7 GO:0044091 membrane biogenesis 7/969 55/18722 0.0226674854912237 0.113359118829794 CAV1/S100A10/ANK3/ANXA2/SPTBN1/FLOT2/CAV2 7 GO:0018105 peptidyl-serine phosphorylation 25/969 315/18722 0.0227278422911212 0.113552298100764 EGFR/AKAP9/CAV1/APP/MIF/PRKDC/ROCK1/PKN2/TFRC/ATP2B4/RICTOR/EIF4G1/RPS6KA5/NSD1/LATS2/SMG1/TXN/DMD/MAST4/MAPK14/WNK1/NEK6/CDK1/CCNB1/AURKA 25 GO:0022409 positive regulation of cell-cell adhesion 23/969 284/18722 0.0228270942426442 0.11393924977274 CAV1/CD46/NFAT5/IGF2/RPS3/SOX4/ANXA1/IL6ST/PLPP3/ANK3/DOCK8/GLI3/TFRC/GCNT2/RHOA/BMP7/XBP1/CITED2/FLOT2/DPP4/GATA3/CD24/HES1 23 GO:0001838 embryonic epithelial tube formation 12/969 121/18722 0.0228967095016789 0.114068831130385 LRP2/PFN1/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/IRX2/BMP7/CITED2/GATA3 12 GO:0043500 muscle adaptation 12/969 121/18722 0.0228967095016789 0.114068831130385 DAG1/IL6ST/ROCK1/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1/CFLAR/CAMK2G/HMOX1 12 GO:0014044 Schwann cell development 5/969 32/18722 0.0231391672526116 0.114621126125259 ITGB4/DAG1/PLEC/NF1/DICER1 5 GO:0033687 osteoblast proliferation 5/969 32/18722 0.0231391672526116 0.114621126125259 ITGAV/LRP5/RHOA/JUNB/PLXNB1 5 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 5/969 32/18722 0.0231391672526116 0.114621126125259 BRD4/TCERG1/CDK12/SUPT6H/HNRNPU 5 GO:0050685 positive regulation of mRNA processing 5/969 32/18722 0.0231391672526116 0.114621126125259 PRDX6/TRA2B/THRAP3/TRA2A/CCNB1 5 GO:0060317 cardiac epithelial to mesenchymal transition 5/969 32/18722 0.0231391672526116 0.114621126125259 TGFBR3/TBX3/JAG1/RBPJ/RTN4 5 GO:0060323 head morphogenesis 5/969 32/18722 0.0231391672526116 0.114621126125259 ANKRD11/NIPBL/EP300/ARID5B/ATP6AP2 5 GO:0009988 cell-cell recognition 8/969 68/18722 0.0237208336088295 0.117391170870969 ALDOA/DOCK8/DLG1/SPESP1/LGALS3/VDAC2/LY6K/CCT8 8 GO:0048144 fibroblast proliferation 9/969 81/18722 0.0238580518807489 0.117787542642222 FTH1/MIF/PRKDC/CDK6/ANXA2/GSTP1/NF1/PAWR/CCNB1 9 GO:0051817 modulation of process of other organism involved in symbiotic interaction 9/969 81/18722 0.0238580518807489 0.117787542642222 JUN/DAG1/CFL1/SERPINB9/EP300/EIF2AK4/RXRA/REST/CAV2 9 GO:1901654 response to ketone 17/969 194/18722 0.0238888594169833 0.117787542642222 EGFR/FOS/ATP2B1/CAV1/FOSB/RPL27/TGFBR3/DUSP1/PARP1/CLDN4/CSNK2B/NR3C1/AKR1B1/LARP1/CALM1/CFLAR/USP8 17 GO:1901342 regulation of vasculature development 27/969 348/18722 0.023908025422829 0.117787542642222 SEMA6A/ITGB1/RHOB/GRN/ADAMTS1/PKM/COL4A2/HSPB1/ISL1/ROCK1/NRP1/GTF2I/BTG1/ITGB8/NF1/ATP2B4/GAB1/AMOT/AGO2/XBP1/EPN2/PDCD6/EMC10/ID1/HMOX1/ANXA3/PGK1 27 GO:0032984 protein-containing complex disassembly 19/969 224/18722 0.0239136208846914 0.117787542642222 CFL1/IGF1R/ARID1A/KIF5B/SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/CALM1/EIF5A/HMGA1/SETX/UVRAG/EPS8/ADD3/STMN1 19 GO:0071772 response to BMP 15/969 165/18722 0.0243791217845188 0.119854459497549 FBN1/LRP2/CRIM1/SPINT1/DDX5/TGFBR3/EGR1/USP9X/TRIM33/SMAD5/BMP7/RBPJ/HTRA1/GATA3/HES1 15 GO:0071773 cellular response to BMP stimulus 15/969 165/18722 0.0243791217845188 0.119854459497549 FBN1/LRP2/CRIM1/SPINT1/DDX5/TGFBR3/EGR1/USP9X/TRIM33/SMAD5/BMP7/RBPJ/HTRA1/GATA3/HES1 15 GO:0002320 lymphoid progenitor cell differentiation 4/969 22/18722 0.0247485168640285 0.120396775184834 PRKDC/SOX4/GATA3/HES1 4 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 4/969 22/18722 0.0247485168640285 0.120396775184834 GSTO1/DMD/CALM1/CALM2 4 GO:0035024 negative regulation of Rho protein signal transduction 4/969 22/18722 0.0247485168640285 0.120396775184834 ITGB1/MET/KANK1/STMN1 4 GO:0048026 positive regulation of mRNA splicing, via spliceosome 4/969 22/18722 0.0247485168640285 0.120396775184834 PRDX6/TRA2B/THRAP3/TRA2A 4 GO:0050860 negative regulation of T cell receptor signaling pathway 4/969 22/18722 0.0247485168640285 0.120396775184834 PHPT1/LGALS3/PAWR/EZR 4 GO:0051220 cytoplasmic sequestering of protein 4/969 22/18722 0.0247485168640285 0.120396775184834 TMSB4X/NFKBIA/GOPC/SRI 4 GO:0051412 response to corticosterone 4/969 22/18722 0.0247485168640285 0.120396775184834 FOS/ATP2B1/FOSB/CALM1 4 GO:0140467 integrated stress response signaling 4/969 22/18722 0.0247485168640285 0.120396775184834 HSPA5/PPP1R15A/EIF2AK4/DDIT3 4 GO:0001658 branching involved in ureteric bud morphogenesis 7/969 56/18722 0.0247889265401609 0.120396775184834 LAMA5/PBX1/LGR4/DLG1/MAGED1/GLI3/TACSTD2 7 GO:0010332 response to gamma radiation 7/969 56/18722 0.0247889265401609 0.120396775184834 RPL26/HSPA5/PRKDC/EGR1/GPX1/PARP1/GATA3 7 GO:0046622 positive regulation of organ growth 7/969 56/18722 0.0247889265401609 0.120396775184834 IGF2/TGFBR3/DDX39B/MAPK14/RBPJ/CDK1/CCNB1 7 GO:0051653 spindle localization 7/969 56/18722 0.0247889265401609 0.120396775184834 ITGB1/DYNC1H1/CFL1/GJA1/KPNB1/DYNLT1/NUSAP1 7 GO:1990089 response to nerve growth factor 7/969 56/18722 0.0247889265401609 0.120396775184834 APP/HSPA5/BPTF/ARPC3/KIDINS220/USP8/ID1 7 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 6/969 44/18722 0.0249004833252246 0.120505029788146 DLG5/DLG1/FAT1/RHOA/CDC42/ARF4 6 GO:0097178 ruffle assembly 6/969 44/18722 0.0249004833252246 0.120505029788146 CAV1/PFN1/KANK1/EPS8L1/EPS8/TACSTD2 6 GO:0006364 rRNA processing 19/969 225/18722 0.024903450472866 0.120505029788146 RPS21/RPL14/RPS6/RPS25/RPL26/RPS8/RPL10A/RPS16/RPL7A/RPL11/PRKDC/RPL27/RPL7/DDX17/RPL35/SNU13/EBNA1BP2/NHP2/NOP10 19 GO:0050769 positive regulation of neurogenesis 19/969 225/18722 0.024903450472866 0.120505029788146 EGFR/LRP2/LRP1/GOLGA4/DAG1/MACF1/SPINT1/CUX1/IL6ST/NRP1/UFL1/GLI3/DICER1/RAB11A/MAN2A1/PLXNB1/MME/OBSL1/HES1 19 GO:0030073 insulin secretion 17/969 195/18722 0.0249595023094381 0.12054877701976 LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/PHPT1/KIF5B/SYT7/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/SRI 17 GO:0045637 regulation of myeloid cell differentiation 18/969 210/18722 0.0249959179606902 0.12054877701976 FBN1/JUN/FOS/CSF3R/ZFP36L1/PRKDC/CDK6/HSPA1A/SCIN/RCOR1/PIK3R1/FOXP1/JAG1/ESRRA/MAPK14/NFKBIA/HSPA1B/PRMT1 18 GO:0008593 regulation of Notch signaling pathway 10/969 95/18722 0.0250047597186031 0.12054877701976 CD46/AAK1/IL6ST/GALNT11/JAG1/MMP14/BMP7/EPN2/NFKBIA/HES1 10 GO:1901379 regulation of potassium ion transmembrane transport 10/969 95/18722 0.0250047597186031 0.12054877701976 AKAP9/CAV1/ITGB1/CD63/ANK3/DLG1/KCNN4/WNK1/VAMP2/YWHAE 10 GO:0034766 negative regulation of ion transmembrane transport 11/969 109/18722 0.0255478425189606 0.122910919021591 CAV1/C4orf3/GSTO1/ANK3/CALM1/GOPC/YWHAE/VDAC1/CALM2/YWHAQ/SRI 11 GO:0043266 regulation of potassium ion transport 11/969 109/18722 0.0255478425189606 0.122910919021591 AKAP9/CAV1/ITGB1/CD63/ANK3/DLG1/KIF5B/KCNN4/WNK1/VAMP2/YWHAE 11 GO:0043242 negative regulation of protein-containing complex disassembly 9/969 82/18722 0.0256152954277312 0.122910919021591 SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EPS8/ADD3 9 GO:2001252 positive regulation of chromosome organization 9/969 82/18722 0.0256152954277312 0.122910919021591 ATRX/PPP1R10/MAP3K4/TPR/RAD50/HNRNPA1/MPHOSPH8/SFPQ/CCT8 9 GO:0071482 cellular response to light stimulus 12/969 123/18722 0.0256510303917175 0.122910919021591 RPL26/DDB1/NPM1/PARP1/USP47/PIK3R1/YY1/NMT1/EP300/EIF2AK4/MME/XPC 12 GO:0010611 regulation of cardiac muscle hypertrophy 8/969 69/18722 0.0256593594819281 0.122910919021591 IL6ST/ROCK1/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1 8 GO:1901224 positive regulation of NIK/NF-kappaB signaling 8/969 69/18722 0.0256593594819281 0.122910919021591 EGFR/APP/NFAT5/RPS3/TRIM44/RHOA/EP300/ACTN4 8 GO:0007162 negative regulation of cell adhesion 24/969 303/18722 0.0257519932494096 0.123241681979318 LRP1/CDH1/SEMA6A/FBLN1/KANK1/DLG5/ANXA1/RASA1/DUSP1/DLG1/MIA3/JAM3/GLI3/GCNT2/PIK3R1/RHOA/PLXNB1/JAG1/MMP14/LGALS3/PAWR/WNK1/ACTN4/TACSTD2 24 GO:0051962 positive regulation of nervous system development 22/969 272/18722 0.0258938121829691 0.123680967720242 EGFR/LRP2/LRP1/GOLGA4/DAG1/MACF1/DLG5/SPINT1/CUX1/IL6ST/NRP1/UFL1/GLI3/DICER1/RAB11A/MAN2A1/PLXNB1/CLSTN1/MME/OBSL1/TPBG/HES1 22 GO:0045766 positive regulation of angiogenesis 16/969 181/18722 0.0259147837071689 0.123680967720242 ITGB1/RHOB/GRN/PKM/HSPB1/ISL1/NRP1/BTG1/ITGB8/GAB1/AGO2/XBP1/PDCD6/EMC10/HMOX1/ANXA3 16 GO:1904018 positive regulation of vasculature development 16/969 181/18722 0.0259147837071689 0.123680967720242 ITGB1/RHOB/GRN/PKM/HSPB1/ISL1/NRP1/BTG1/ITGB8/GAB1/AGO2/XBP1/PDCD6/EMC10/HMOX1/ANXA3 16 GO:1901214 regulation of neuron death 25/969 319/18722 0.0260095354629411 0.123873803248546 JUN/FOS/LRP1/GRN/RASA1/ISL1/EGR1/NRP1/PARP1/DHCR24/NF1/EIF4G1/RHOA/MCL1/TFAP2A/TMEM259/BTG2/DDIT3/CDC42/REST/GCLM/GATA3/KRAS/HMOX1/PSMC1 25 GO:0043393 regulation of protein binding 17/969 196/18722 0.0260659132225774 0.123873803248546 LRP1/CAV1/APP/RPL11/TGFBR3/ROCK1/ANXA2/NRP1/PTPRF/RAN/LRPAP1/TCF7L2/EP300/CDC42/SPPL3/ID1/AURKA 17 GO:0006482 protein demethylation 5/969 33/18722 0.0261448153431203 0.123873803248546 KDM5A/KDM5B/JARID2/JMJD1C/KDM2A 5 GO:0008214 protein dealkylation 5/969 33/18722 0.0261448153431203 0.123873803248546 KDM5A/KDM5B/JARID2/JMJD1C/KDM2A 5 GO:0045648 positive regulation of erythrocyte differentiation 5/969 33/18722 0.0261448153431203 0.123873803248546 PRKDC/HSPA1A/MAPK14/HSPA1B/PRMT1 5 GO:0071539 protein localization to centrosome 5/969 33/18722 0.0261448153431203 0.123873803248546 GOLGB1/CEP350/PCM1/HOOK3/AURKA 5 GO:0150117 positive regulation of cell-substrate junction organization 5/969 33/18722 0.0261448153431203 0.123873803248546 IQGAP1/S100A10/ROCK1/NRP1/PIK3R1 5 GO:2000036 regulation of stem cell population maintenance 5/969 33/18722 0.0261448153431203 0.123873803248546 ZC3H13/NCOA3/BMP7/REST/LBH 5 GO:0005996 monosaccharide metabolic process 21/969 257/18722 0.0263263700996323 0.124621023678151 GAPDH/ALDOA/TPI1/GSTO1/IGF2/SLC2A1/ENO1/DDB1/GAA/LRP5/RANBP2/PMAIP1/FUT8/MAN2A1/SORBS1/AKR1B1/MAPK14/EP300/SLC35B4/LCMT1/PGK1 21 GO:0009615 response to virus 28/969 367/18722 0.0263576009076675 0.124655947822145 TPT1/CFL1/ENO1/CDK6/DDX17/HSPB1/PUM1/TRIM44/NCBP3/PMAIP1/SETD2/ITGB8/EXOC1/CREBZF/ANKRD17/PUM2/TRIM56/ADAR/EIF5A/HMGA1/MAPK14/EIF2AK4/PCBP2/HTRA1/BANF1/GATA3/NPC2/STMN1 28 GO:0022407 regulation of cell-cell adhesion 33/969 448/18722 0.0266596827520548 0.124847157651406 CAV1/CD46/CDH1/TENM3/NFAT5/IGF2/DLG5/RPS3/SOX4/ANXA1/IL6ST/PLPP3/ANK3/DOCK8/DLG1/MIA3/GLI3/TFRC/GCNT2/RHOA/JAG1/LGALS3/PAWR/BMP7/MAPK14/WNK1/XBP1/CITED2/FLOT2/DPP4/GATA3/CD24/HES1 33 GO:0006983 ER overload response 3/969 13/18722 0.0267734556806882 0.124847157651406 HSPA5/CCDC47/DDIT3 3 GO:0010745 negative regulation of macrophage derived foam cell differentiation 3/969 13/18722 0.0267734556806882 0.124847157651406 ITGAV/ABCA1/NFKBIA 3 GO:0032429 regulation of phospholipase A2 activity 3/969 13/18722 0.0267734556806882 0.124847157651406 EGFR/LRP1/ANXA1 3 GO:0034982 mitochondrial protein processing 3/969 13/18722 0.0267734556806882 0.124847157651406 YME1L1/AFG3L2/STOML2 3 GO:0035331 negative regulation of hippo signaling 3/969 13/18722 0.0267734556806882 0.124847157651406 DLG5/MAPK14/VGLL4 3 GO:0042769 DNA damage response, detection of DNA damage 3/969 13/18722 0.0267734556806882 0.124847157651406 RPS3/SOX4/PARP1 3 GO:0044090 positive regulation of vacuole organization 3/969 13/18722 0.0267734556806882 0.124847157651406 GRN/ANXA2/RAB3GAP2 3 GO:0048012 hepatocyte growth factor receptor signaling pathway 3/969 13/18722 0.0267734556806882 0.124847157651406 MET/NRP1/STMN1 3 GO:0051481 negative regulation of cytosolic calcium ion concentration 3/969 13/18722 0.0267734556806882 0.124847157651406 ATP2B1/LRP1/GTF2I 3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore 3/969 13/18722 0.0267734556806882 0.124847157651406 CDC42/HNRNPU/CCNB1 3 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 3/969 13/18722 0.0267734556806882 0.124847157651406 EGR1/RBPJ/CITED2 3 GO:0098814 spontaneous synaptic transmission 3/969 13/18722 0.0267734556806882 0.124847157651406 APP/ITGB1/PPP1R9A 3 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 3/969 13/18722 0.0267734556806882 0.124847157651406 NRP2/NRP1/PLXNB1 3 GO:0035107 appendage morphogenesis 13/969 138/18722 0.026803450712009 0.124847157651406 FBN2/PBX1/ATRX/SOX4/FRAS1/LRP5/NIPBL/GLI3/TBX3/TFAP2A/MBNL1/BMP7/TMEM107 13 GO:0035108 limb morphogenesis 13/969 138/18722 0.026803450712009 0.124847157651406 FBN2/PBX1/ATRX/SOX4/FRAS1/LRP5/NIPBL/GLI3/TBX3/TFAP2A/MBNL1/BMP7/TMEM107 13 GO:0034767 positive regulation of ion transmembrane transport 15/969 167/18722 0.026804154398178 0.124847157651406 TCAF1/AKAP9/ITGB1/GSTO1/ANK3/TMSB4X/KIF5B/KCNN4/SLC9A1/DMD/CALM1/WNK1/ACTN4/CALM2/SRI 15 GO:0034249 negative regulation of cellular amide metabolic process 22/969 273/18722 0.0268437875406957 0.124920421805589 GAPDH/ZFP36L1/RPL13A/RPS3/ORMDL1/ROCK1/PUM1/TNRC6B/TPR/YBX1/IGF2BP3/PURA/TNRC6A/EIF4G1/CELF1/TIA1/LARP1/AGO2/EIF2AK4/RTN4/BTG2/PABPC1 22 GO:0009895 negative regulation of catabolic process 25/969 320/18722 0.0268842852803783 0.124997575511794 EGFR/FUS/MET/MYCBP2/RPL11/ROCK1/ANXA2/EIF3H/YBX1/ATP2B4/EIF4G1/MCL1/NCOR1/SMG1/LARP1/WAC/MAPK14/MDM4/THRAP3/PABPC1/HMOX1/HNRNPC/HNRNPU/TIMP2/TAF9 25 GO:0046777 protein autophosphorylation 19/969 227/18722 0.026976103572564 0.125312993129084 EGFR/CAV1/AAK1/IQGAP1/EPHB4/IGF1R/RAD50/SMG1/TAOK3/TAOK1/CALM1/CDK12/WNK1/EIF2AK4/NEK6/SLK/TRIM24/CALM2/AURKA 19 GO:0002011 morphogenesis of an epithelial sheet 7/969 57/18722 0.0270424865642706 0.125398433704417 DAG1/FERMT1/RHOA/JAG1/BMP7/RREB1/RHOC 7 GO:0061005 cell differentiation involved in kidney development 7/969 57/18722 0.0270424865642706 0.125398433704417 IQGAP1/LGR4/GLI3/JAG1/GATA3/CD24/HES1 7 GO:0014812 muscle cell migration 11/969 110/18722 0.0271116530349391 0.125480900284194 LRP1/S100A11/IQGAP1/ADAMTS1/SEMA6D/ANXA1/ROCK1/GSTP1/NRP1/RHOA/GNA12 11 GO:0097237 cellular response to toxic substance 12/969 124/18722 0.0271155115028412 0.125480900284194 GPX3/GSTO1/PRDX6/PRDX1/GPX4/GSTP1/GPX1/PPP1R9A/S100A9/TXN/SOD3/BMP7 12 GO:0006457 protein folding 18/969 212/18722 0.0271563142406092 0.125480900284194 HSP90B1/HSPA5/NKTR/GRN/LMAN1/HSPB1/PPIA/RANBP2/PTGES3/HSPA1A/PPIG/DNAJB1/DNAJB14/CCDC47/PDIA3/P4HB/HSPA1B/CCT8 18 GO:0043523 regulation of neuron apoptotic process 18/969 212/18722 0.0271563142406092 0.125480900284194 JUN/LRP1/GRN/RASA1/ISL1/NRP1/PARP1/NF1/RHOA/MCL1/TFAP2A/BTG2/DDIT3/CDC42/GCLM/GATA3/KRAS/HMOX1 18 GO:0045165 cell fate commitment 21/969 258/18722 0.0273194014351545 0.126122961042506 ITGB1/PRKDC/LMO4/NR2F2/ISL1/NRP1/IFRD1/CTSL/GLI3/TBX3/EPAS1/RHOA/MCL1/SMAD5/JAG1/TCF7L2/RBPJ/RTF1/CDC42/GATA3/HES1 21 GO:0060421 positive regulation of heart growth 6/969 45/18722 0.0275164401732035 0.126696842594856 TGFBR3/DDX39B/MAPK14/RBPJ/CDK1/CCNB1 6 GO:1901985 positive regulation of protein acetylation 6/969 45/18722 0.0275164401732035 0.126696842594856 SOX4/ISL1/BRD7/RPS6KA5/TAOK1/GATA3 6 GO:1904646 cellular response to amyloid-beta 6/969 45/18722 0.0275164401732035 0.126696842594856 LRP1/APP/GJA1/IGF1R/PARP1/CASP4 6 GO:0043543 protein acylation 20/969 243/18722 0.0277304256615722 0.12756972227762 SOX4/ISL1/NCOA3/ZNF451/MORF4L2/BRD7/RPS6KA5/USP22/TAOK1/NMT1/PHF20L1/EP300/PHF14/SETD5/PHF20/CDYL/EID1/GATA3/IWS1/TAF9 20 GO:0009914 hormone transport 24/969 306/18722 0.0284990537132416 0.130990373531575 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/CYP19A1/PHPT1/KIF5B/TBX3/KDM5B/SYT7/CCDC186/TCF7L2/TRPV6/HMGN3/DPP4/TMF1/REST/CAMK2G/GATA3/SRI 24 GO:0018210 peptidyl-threonine modification 12/969 125/18722 0.0286398589675914 0.131404840788284 APP/PRKDC/GALNT11/ROCK1/CSNK2B/EIF4G1/CALM1/BMP7/WNK1/GALNT1/CDK1/CALM2 12 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 4/969 23/18722 0.0287652387795248 0.131404840788284 ENPEP/RHOA/MME/ATP6AP2 4 GO:0003283 atrial septum development 4/969 23/18722 0.0287652387795248 0.131404840788284 SOX4/ISL1/MDM4/GJA5 4 GO:0016973 poly(A)+ mRNA export from nucleus 4/969 23/18722 0.0287652387795248 0.131404840788284 PABPN1/THOC2/ZC3H11A/IWS1 4 GO:0021871 forebrain regionalization 4/969 23/18722 0.0287652387795248 0.131404840788284 ADGRG1/TRA2B/PGAP1/GLI3 4 GO:0051457 maintenance of protein location in nucleus 4/969 23/18722 0.0287652387795248 0.131404840788284 SKP1/TXN/TAF3/HNRNPU 4 GO:0090335 regulation of brown fat cell differentiation 4/969 23/18722 0.0287652387795248 0.131404840788284 BMP7/MAPK14/RREB1/HNRNPU 4 GO:0045860 positive regulation of protein kinase activity 29/969 386/18722 0.0288191960037794 0.131439713799337 EGFR/DAG1/RPLP1/IQGAP1/IGF2/RPS3/EGR1/DLG1/AKAP13/MAGED1/NPM1/PPIA/MAP3K4/PRLR/PPP1R9A/ATP2B4/RICTOR/RHOA/TXN/TAOK3/TAOK1/CALM1/WNK1/CKS1B/JTB/KRAS/CD24/CALM2/CCNB1 29 GO:0043270 positive regulation of ion transport 22/969 275/18722 0.0288231748974436 0.131439713799337 TCAF1/AKAP9/ATP2B1/CAV1/ITGB1/GSTO1/ANK3/DLG1/TMSB4X/KIF5B/KCNN4/SLC9A1/LGALS3/DMD/CALM1/WNK1/SLC6A4/AHCYL1/ACTN4/HOMER1/CALM2/SRI 22 GO:0010922 positive regulation of phosphatase activity 5/969 34/18722 0.0293886167113247 0.133052140347549 SLC39A10/PPP1R15A/PPP1R12A/CALM1/CALM2 5 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 5/969 34/18722 0.0293886167113247 0.133052140347549 GSTO1/DMD/CALM1/CALM2/SRI 5 GO:0032743 positive regulation of interleukin-2 production 5/969 34/18722 0.0293886167113247 0.133052140347549 RPS3/ANXA1/SPTBN1/PDE4B/STOML2 5 GO:0035308 negative regulation of protein dephosphorylation 5/969 34/18722 0.0293886167113247 0.133052140347549 BOD1L1/PPP1R15A/ROCK1/LGALS3/YWHAE 5 GO:0035909 aorta morphogenesis 5/969 34/18722 0.0293886167113247 0.133052140347549 LRP1/SOX4/JAG1/RBPJ/HES1 5 GO:0098751 bone cell development 5/969 34/18722 0.0293886167113247 0.133052140347549 FBN1/WASF2/ANXA2/FOXP1/EP300 5 GO:2000758 positive regulation of peptidyl-lysine acetylation 5/969 34/18722 0.0293886167113247 0.133052140347549 SOX4/ISL1/BRD7/RPS6KA5/GATA3 5 GO:0061157 mRNA destabilization 9/969 84/18722 0.0294008886227068 0.133052140347549 ZFP36L1/ROCK1/PUM1/TNRC6B/TNRC6A/CELF1/AGO2/BTG2/PABPC1 9 GO:0044380 protein localization to cytoskeleton 7/969 58/18722 0.0294313574898137 0.133052140347549 GOLGB1/CEP350/DIAPH1/PCM1/HOOK3/HNRNPU/AURKA 7 GO:2000649 regulation of sodium ion transmembrane transporter activity 7/969 58/18722 0.0294313574898137 0.133052140347549 UTRN/ANK3/KIF5B/SLC9A1/DMD/WNK1/ACTN4 7 GO:2001257 regulation of cation channel activity 16/969 184/18722 0.0296023157229735 0.133709336186914 AHNAK/CAV1/APP/ITGB1/GSTO1/ANK3/DLG1/TMSB4X/KIF5B/PDE4B/DMD/CALM1/HOMER1/VAMP2/CALM2/SRI 16 GO:0061515 myeloid cell development 8/969 71/18722 0.0298620641594657 0.13476610302018 FBN1/RPS6/APP/WASF2/ANXA2/FOXP1/EP300/CITED2 8 GO:0017148 negative regulation of translation 20/969 245/18722 0.0298969797432769 0.134807261551652 GAPDH/ZFP36L1/RPL13A/RPS3/ROCK1/PUM1/TNRC6B/TPR/YBX1/IGF2BP3/PURA/TNRC6A/EIF4G1/CELF1/TIA1/LARP1/AGO2/EIF2AK4/BTG2/PABPC1 20 GO:0007389 pattern specification process 32/969 436/18722 0.0299933774331539 0.13512533660833 LRP2/NRP2/BPTF/PBX1/ADGRG1/WLS/PRKDC/NR2F2/GALNT11/TRA2B/ISL1/LRP5/NRP1/PGAP1/GLI3/TBX3/BHLHE41/AHI1/IRX2/SMAD5/MTF2/YY1/BMP7/EP300/TMEM107/RBPJ/CITED2/BTG2/DDIT3/ATP6AP2/HES1/AURKA 32 GO:0043502 regulation of muscle adaptation 10/969 98/18722 0.0302293359274785 0.135955178893315 DAG1/IL6ST/ROCK1/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1/CAMK2G 10 GO:0031057 negative regulation of histone modification 6/969 46/18722 0.0303076508631289 0.135955178893315 KDM5A/ZNF451/JARID2/UBR5/MTF2/SUPT6H 6 GO:0033047 regulation of mitotic sister chromatid segregation 6/969 46/18722 0.0303076508631289 0.135955178893315 DUSP1/TPR/HNRNPU/LCMT1/CCNB1/PTTG1 6 GO:0050919 negative chemotaxis 6/969 46/18722 0.0303076508631289 0.135955178893315 NRP2/ITGAV/SEMA6A/SEMA6D/RHOA/DPP4 6 GO:0055010 ventricular cardiac muscle tissue morphogenesis 6/969 46/18722 0.0303076508631289 0.135955178893315 LRP2/DSP/TGFBR3/ISL1/LY6E/RBPJ 6 GO:0034614 cellular response to reactive oxygen species 14/969 155/18722 0.0303867910736965 0.136193284863755 JUN/EGFR/FOS/MET/RHOB/RPS3/ANXA1/PRDX1/TXN/SOD3/PAWR/BMP7/SETX/CDK1 14 GO:0000956 nuclear-transcribed mRNA catabolic process 11/969 112/18722 0.0304441968502054 0.136333652732796 ZFP36L1/DDX5/TNRC6B/TNRC6A/UPF2/SMG1/AGO2/BTG2/THRAP3/PABPC1/SSB 11 GO:0008584 male gonad development 13/969 141/18722 0.0312322800712103 0.139743061346014 LRP2/SF1/ADGRG1/ATRX/EIF2S2/KDM5A/CTSV/MMP14/RHOBTB3/ARID5B/CITED2/TMF1/GATA3 13 GO:0060021 roof of mouth development 9/969 85/18722 0.0314332544075072 0.140521973938095 TGFBR3/FRAS1/DLG1/ITGB8/GLI3/TBX3/TFAP2A/TMEM107/ARID5B 9 GO:0009636 response to toxic substance 21/969 262/18722 0.0315778497626177 0.140807033156519 FOS/GPX3/CDH1/GSTO1/UBA52/PRDX6/PRDX1/GPX4/DHRS2/GSTP1/GPX1/PPP1R9A/KDM5B/S100A9/TXN/SOD3/DNMT3A/BMP7/SLC6A4/CDK1/CCNB1 21 GO:0010466 negative regulation of peptidase activity 21/969 262/18722 0.0315778497626177 0.140807033156519 GAPDH/ITIH5/APLP2/LRP1/APP/CRIM1/SPINT1/SERPINB9/ROCK1/ANXA2/GPX1/BIRC6/USP47/DHCR24/SERPINB1/SERPINH1/SIAH2/SERPINB6/CSTB/TIMP2/PTTG1 21 GO:0031330 negative regulation of cellular catabolic process 21/969 262/18722 0.0315778497626177 0.140807033156519 FUS/MET/RPL11/ROCK1/ANXA2/EIF3H/YBX1/ATP2B4/EIF4G1/MCL1/SMG1/LARP1/WAC/MAPK14/THRAP3/PABPC1/HMOX1/HNRNPC/HNRNPU/TIMP2/TAF9 21 GO:0035306 positive regulation of dephosphorylation 7/969 59/18722 0.0319585303289177 0.142341547441165 SLC39A10/PPP1R15A/PPIA/PPP1R12A/CALM1/SPPL3/CALM2 7 GO:0033209 tumor necrosis factor-mediated signaling pathway 10/969 99/18722 0.0321304082544751 0.142341547441165 KRT8/KRT18/GSTP1/TMSB4X/HSPA1A/EIF5A/ACTN4/NFKBIA/HSPA1B/CASP4 10 GO:0000271 polysaccharide biosynthetic process 8/969 72/18722 0.0321311231950819 0.142341547441165 IGF2/AGL/CLTC/PTGES3/SORBS1/B4GALT5/UGP2/B3GNT2 8 GO:0014743 regulation of muscle hypertrophy 8/969 72/18722 0.0321311231950819 0.142341547441165 IL6ST/ROCK1/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1 8 GO:0071479 cellular response to ionizing radiation 8/969 72/18722 0.0321311231950819 0.142341547441165 RPL26/HSPA5/RHOB/EGR1/NIPBL/MAPK14/EEF1D/GATA3 8 GO:1905818 regulation of chromosome separation 8/969 72/18722 0.0321311231950819 0.142341547441165 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1/PTTG1 8 GO:0051054 positive regulation of DNA metabolic process 17/969 201/18722 0.0321577208845651 0.142341547441165 EGFR/FUS/ATRX/PRKDC/RPS3/PPP1R10/RIF1/PARP1/MAP3K4/PTGES3/USP9X/RAD50/TFRC/HNRNPA1/DDX39B/ANXA3/CCT8 17 GO:0051604 protein maturation 23/969 294/18722 0.0323006956842443 0.142341547441165 GLG1/ENO1/SOX4/ENPEP/PARP1/DHCR24/CTSL/GLI3/CPD/ASPH/PISD/YME1L1/MMP14/PCSK7/EP300/MME/SERPINH1/SPPL3/ATP6AP2/AFG3L2/STOML2/PGK1/CASP4 23 GO:0048285 organelle fission 35/969 488/18722 0.0323135107382971 0.142341547441165 RPL24/ATRX/IGF2/DUSP1/LRP5/NIPBL/PHIP/TPR/HSPA1A/RAN/RAD50/RAB11A/ANAPC11/RHOA/PDS5A/EML4/KPNB1/BMP7/NEK6/UBE2C/STAG1/CDC42/EPS8/OBSL1/HSPA1B/CAV2/HNRNPU/LCMT1/NUSAP1/CDC20/RANBP1/CCNB1/PTTG1/CCNE1/AURKA 35 GO:0051047 positive regulation of secretion 24/969 310/18722 0.0325026151205001 0.142341547441165 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ISL1/PPIA/CYP19A1/PHPT1/FRMD4A/KIF5B/KCNN4/SCIN/EXOC1/SYT7/EXPH5/TCF7L2/SLC6A4/XBP1/TMF1/EZR/SRI 24 GO:0045765 regulation of angiogenesis 26/969 342/18722 0.0326495917905624 0.142341547441165 SEMA6A/ITGB1/RHOB/GRN/ADAMTS1/PKM/COL4A2/HSPB1/ISL1/ROCK1/NRP1/GTF2I/BTG1/ITGB8/NF1/ATP2B4/GAB1/AMOT/AGO2/XBP1/EPN2/PDCD6/EMC10/HMOX1/ANXA3/PGK1 26 GO:0000054 ribosomal subunit export from nucleus 3/969 14/18722 0.0327927256032975 0.142341547441165 NPM1/RAN/XPO1 3 GO:0001771 immunological synapse formation 3/969 14/18722 0.0327927256032975 0.142341547441165 DOCK8/DLG1/LGALS3 3 GO:0031054 pre-miRNA processing 3/969 14/18722 0.0327927256032975 0.142341547441165 DICER1/ADAR/AGO2 3 GO:0033750 ribosome localization 3/969 14/18722 0.0327927256032975 0.142341547441165 NPM1/RAN/XPO1 3 GO:0035437 maintenance of protein localization in endoplasmic reticulum 3/969 14/18722 0.0327927256032975 0.142341547441165 HSPA5/GJA1/KDELR2 3 GO:0038166 angiotensin-activated signaling pathway 3/969 14/18722 0.0327927256032975 0.142341547441165 CAV1/ROCK1/AHCYL1 3 GO:0042921 glucocorticoid receptor signaling pathway 3/969 14/18722 0.0327927256032975 0.142341547441165 PTGES3/ARID1A/NR3C1 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/969 14/18722 0.0327927256032975 0.142341547441165 RPL26/DDX5/PMAIP1 3 GO:0043558 regulation of translational initiation in response to stress 3/969 14/18722 0.0327927256032975 0.142341547441165 PPP1R15A/NPM1/EIF2AK4 3 GO:0044764 multi-organism cellular process 3/969 14/18722 0.0327927256032975 0.142341547441165 CAV1/CTSL/CAV2 3 GO:0060911 cardiac cell fate commitment 3/969 14/18722 0.0327927256032975 0.142341547441165 ISL1/TBX3/RBPJ 3 GO:0061709 reticulophagy 3/969 14/18722 0.0327927256032975 0.142341547441165 UFL1/RB1CC1/UFC1 3 GO:0099188 postsynaptic cytoskeleton organization 3/969 14/18722 0.0327927256032975 0.142341547441165 ACTG1/WASF2/PPP1R9A 3 GO:0046546 development of primary male sexual characteristics 13/969 142/18722 0.0328198579546527 0.142341547441165 LRP2/SF1/ADGRG1/ATRX/EIF2S2/KDM5A/CTSV/MMP14/RHOBTB3/ARID5B/CITED2/TMF1/GATA3 13 GO:2000045 regulation of G1/S transition of mitotic cell cycle 13/969 142/18722 0.0328198579546527 0.142341547441165 EGFR/RPL26/ADAMTS1/PRKDC/SOX4/ANXA1/DLG1/CTDSPL/BRD7/EIF4G1/ANKRD17/WAC/PSME2 13 GO:0002209 behavioral defense response 5/969 35/18722 0.0328752865980646 0.142341547441165 GJA1/EIF4G1/EP300/DPP4/VDAC1 5 GO:0032205 negative regulation of telomere maintenance 5/969 35/18722 0.0328752865980646 0.142341547441165 PARP1/RAD50/HNRNPA1/HNRNPC/HNRNPU 5 GO:0032350 regulation of hormone metabolic process 5/969 35/18722 0.0328752865980646 0.142341547441165 EGR1/TCF7L2/REST/GATA3/STC2 5 GO:0040001 establishment of mitotic spindle localization 5/969 35/18722 0.0328752865980646 0.142341547441165 ITGB1/GJA1/KPNB1/DYNLT1/NUSAP1 5 GO:0045454 cell redox homeostasis 5/969 35/18722 0.0328752865980646 0.142341547441165 PRDX6/PRDX1/GPX1/TXN/DDIT3 5 GO:0045907 positive regulation of vasoconstriction 5/969 35/18722 0.0328752865980646 0.142341547441165 EGFR/CAV1/GJA1/RHOA/GJA5 5 GO:0086005 ventricular cardiac muscle cell action potential 5/969 35/18722 0.0328752865980646 0.142341547441165 CAV1/DSP/DLG1/DSG2/DSC2 5 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 5/969 35/18722 0.0328752865980646 0.142341547441165 GSTO1/DMD/CALM1/CALM2/SRI 5 GO:1905508 protein localization to microtubule organizing center 5/969 35/18722 0.0328752865980646 0.142341547441165 GOLGB1/CEP350/PCM1/HOOK3/AURKA 5 GO:0003148 outflow tract septum morphogenesis 4/969 24/18722 0.0331460841946178 0.142686520593964 LRP2/NRP2/ISL1/NRP1 4 GO:0021801 cerebral cortex radial glia-guided migration 4/969 24/18722 0.0331460841946178 0.142686520593964 LAMB1/ADGRG1/GLI3/RTN4 4 GO:0022030 telencephalon glial cell migration 4/969 24/18722 0.0331460841946178 0.142686520593964 LAMB1/ADGRG1/GLI3/RTN4 4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 4/969 24/18722 0.0331460841946178 0.142686520593964 HSPA5/RBPJ/CHD6/DDIT3 4 GO:0060149 negative regulation of posttranscriptional gene silencing 4/969 24/18722 0.0331460841946178 0.142686520593964 NEAT1/KCNQ1OT1/NCOR1/ADAR 4 GO:0060967 negative regulation of gene silencing by RNA 4/969 24/18722 0.0331460841946178 0.142686520593964 NEAT1/KCNQ1OT1/NCOR1/ADAR 4 GO:1903077 negative regulation of protein localization to plasma membrane 4/969 24/18722 0.0331460841946178 0.142686520593964 CLTC/HECTD1/PPFIA1/GOPC 4 GO:0014911 positive regulation of smooth muscle cell migration 6/969 47/18722 0.0332777767162256 0.143135523554728 LRP1/S100A11/IQGAP1/ADAMTS1/SEMA6D/NRP1 6 GO:0021537 telencephalon development 20/969 248/18722 0.0333819509988363 0.143465522960459 LRP1/LAMB1/ADGRG1/SLC2A1/CDK6/TRA2B/TACC2/SLC38A2/KIF5B/GLI3/NF1/ATP2B4/RHOA/CELF1/NFIB/RTN4/UQCRQ/BTG2/ANXA3/HES1 20 GO:0016051 carbohydrate biosynthetic process 17/969 202/18722 0.0334925776923269 0.143822687773295 TPI1/IGF2/AGL/DDB1/CLTC/RANBP2/PTGES3/FUT8/SORBS1/AKR1B1/EP300/B4GALT5/UGP2/B3GNT2/SLC35B4/PGK1/NANS 17 GO:0032413 negative regulation of ion transmembrane transporter activity 9/969 86/18722 0.0335612103505605 0.143999084804622 CAV1/C4orf3/GSTO1/ANK3/CALM1/GOPC/YWHAE/CALM2/SRI 9 GO:0007041 lysosomal transport 11/969 114/18722 0.0340591482546592 0.145776501866379 LRP1/RHOB/GRN/PSAP/GCC2/HSPA1A/ZFYVE16/HOOK2/GNPTAB/HGSNAT/HOOK3 11 GO:0046660 female sex differentiation 11/969 114/18722 0.0340591482546592 0.145776501866379 LRP2/HSPA5/ADAMTS1/NR2F2/CYP19A1/TBX3/NRIP1/MMP14/ZFX/ARID5B/IDH1 11 GO:0051261 protein depolymerization 11/969 114/18722 0.0340591482546592 0.145776501866379 CFL1/SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EPS8/ADD3/STMN1 11 GO:0021700 developmental maturation 22/969 280/18722 0.0342545203934667 0.146492736150783 APP/PFN1/DAG1/CD63/RERE/FERMT1/EPAS1/RHOA/PLXNB1/ANKRD17/AKR1B1/B4GALT5/RBPJ/CLSTN1/TFCP2L1/DDIT3/ATP6AP2/GATA3/HES1/CDC20/CCNB1/AURKA 22 GO:0031667 response to nutrient levels 34/969 474/18722 0.0344362883573716 0.147125244589352 JUN/EGFR/ATP2B1/LDHA/KRT18/HSPA5/SLC2A1/AGL/PLEC/GSTP1/ADRB1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/EIF4G1/CSH1/ABCA1/SRSF2/CTSV/LARP1/DNMT3A/BMP7/SLC6A4/EIF2AK4/XBP1/ITFG2/DDIT3/GCLM/TRIM24/HMOX1/DNAJC15/NUCB2/STC2 34 GO:0038061 NIK/NF-kappaB signaling 13/969 143/18722 0.0344647553264031 0.147125244589352 EGFR/APP/NFAT5/RPS3/PRDX1/TRIM44/TMSB4X/DICER1/RHOA/BMP7/EP300/ACTN4/NFKBIA 13 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 8/969 73/18722 0.0345150305906134 0.147125244589352 LRP1/DYNLL1/LRP5/PHPT1/KIF5B/CCDC186/HMGN3/SRI 8 GO:0070988 demethylation 8/969 73/18722 0.0345150305906134 0.147125244589352 TET2/KDM5A/USP9X/KDM5B/JARID2/JMJD1C/KDM2A/GATA3 8 GO:0030071 regulation of mitotic metaphase/anaphase transition 7/969 60/18722 0.0346267859523173 0.147481323053635 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1 7 GO:0030336 negative regulation of cell migration 26/969 344/18722 0.0346997750218442 0.147671843863321 TCAF1/LRP1/CDH1/MIF/DAG1/RHOB/KANK1/ADGRG1/DLG5/SEMA6D/GJA1/NR2F2/DUSP1/MIA3/GSTP1/NF1/ATP2B4/CSNK2B/RHOA/GNA12/JAG1/VCL/CITED2/DPP4/TACSTD2/HMOX1 26 GO:0034765 regulation of ion transmembrane transport 35/969 491/18722 0.0348608927568619 0.148236798655297 TCAF1/AHNAK/AKAP9/CAV1/CLIC3/APP/C4orf3/ITGB1/UTRN/GSTO1/CD63/ANK3/DLG1/TMSB4X/DIAPH1/KIF5B/KCNN4/ATP2B4/PDE4B/SLC9A1/CLIC1/DMD/CALM1/WNK1/AHCYL1/ACTN4/GJA5/HOMER1/VAMP2/GOPC/YWHAE/VDAC1/CALM2/YWHAQ/SRI 35 GO:0007249 I-kappaB kinase/NF-kappaB signaling 22/969 281/18722 0.0354268499719891 0.150520908905378 GAPDH/WLS/GJA1/BRD4/ASH1L/HSPB1/ROCK1/AKAP13/GSTP1/UFL1/ERC1/TFRC/RHOA/HACD3/ANKRD17/USP10/NEK6/CFLAR/NFKBIA/EEF1D/HMOX1/RHOC 22 GO:0007029 endoplasmic reticulum organization 9/969 87/18722 0.035786557511177 0.151556361064352 LMAN1/MIA3/SEC31A/EMC1/CCDC47/RAB3GAP2/RTN4/EMC10/CAV2 9 GO:0061014 positive regulation of mRNA catabolic process 9/969 87/18722 0.035786557511177 0.151556361064352 ZFP36L1/ROCK1/PUM1/TNRC6B/TNRC6A/CELF1/AGO2/BTG2/PABPC1 9 GO:1901879 regulation of protein depolymerization 9/969 87/18722 0.035786557511177 0.151556361064352 SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EPS8/ADD3 9 GO:1903578 regulation of ATP metabolic process 9/969 87/18722 0.035786557511177 0.151556361064352 APP/ENO1/TMSB4X/PARP1/RHOA/NCOR1/EP300/PGAM1/DNAJC15 9 GO:0034764 positive regulation of transmembrane transport 18/969 219/18722 0.0358309452172712 0.151621473445716 TCAF1/AKAP9/ITGB1/GSTO1/ANK3/TMSB4X/KIF5B/KCNN4/SLC9A1/PIK3R1/SORBS1/DMD/CALM1/MAPK14/WNK1/ACTN4/CALM2/SRI 18 GO:0032527 protein exit from endoplasmic reticulum 6/969 48/18722 0.0364300975528065 0.153876304141442 HSP90B1/GCC2/SEL1L/FAF2/TM9SF4/SEC13 6 GO:0042149 cellular response to glucose starvation 6/969 48/18722 0.0364300975528065 0.153876304141442 HSPA5/SLC2A1/PMAIP1/HNRNPA1/XBP1/ITFG2 6 GO:0009060 aerobic respiration 16/969 189/18722 0.0365901155105551 0.153876304141442 COX6A1/UQCRH/COX8C/RHOA/COX5A/IDH1/UQCRQ/COX7B/CDK1/DNAJC15/GHITM/MDH2/STOML2/NDUFA6/CCNB1/SDHC 16 GO:0046578 regulation of Ras protein signal transduction 16/969 189/18722 0.0365901155105551 0.153876304141442 ITGB1/MET/KANK1/ADGRG1/RASA1/AKAP13/NRP1/EPS8L1/DENND4C/ABCA1/ARFGEF1/EPS8/KRAS/DYNLT1/TIMP2/STMN1 16 GO:0003203 endocardial cushion morphogenesis 5/969 36/18722 0.0366087752301379 0.153876304141442 ISL1/TBX3/BMP7/MDM4/RBPJ 5 GO:0008207 C21-steroid hormone metabolic process 5/969 36/18722 0.0366087752301379 0.153876304141442 CYP11A1/DHRS2/EGR1/AKR1B1/REST 5 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 5/969 36/18722 0.0366087752301379 0.153876304141442 LRP1/DYNLL1/PHPT1/KIF5B/SRI 5 GO:1903539 protein localization to postsynaptic membrane 5/969 36/18722 0.0366087752301379 0.153876304141442 DAG1/DLG1/RAB11A/CLSTN1/VAMP2 5 GO:1903532 positive regulation of secretion by cell 22/969 282/18722 0.036628802593179 0.153876304141442 EGFR/LRP1/DYNLL1/MYH10/WLS/GJA1/SOX4/ISL1/PPIA/CYP19A1/PHPT1/FRMD4A/KIF5B/KCNN4/EXOC1/SYT7/EXPH5/TCF7L2/SLC6A4/TMF1/EZR/SRI 22 GO:0007584 response to nutrient 15/969 174/18722 0.0367092863095416 0.154090546388486 EGFR/ATP2B1/LDHA/AGL/GSTP1/ABCA1/SRSF2/DNMT3A/BMP7/SLC6A4/XBP1/GCLM/TRIM24/HMOX1/STC2 15 GO:0070972 protein localization to endoplasmic reticulum 8/969 74/18722 0.037015902717064 0.155252895344604 HSPA5/GJA1/PPP1R15A/MIA3/SEC62/RAB3GAP2/RTN4/KDELR2 8 GO:0040014 regulation of multicellular organism growth 7/969 61/18722 0.0374386868164721 0.156900222376009 APP/IGF2/ADRB1/NIPBL/CELF1/AFG3L2/EZR 7 GO:0048143 astrocyte activation 4/969 25/18722 0.0378943709018802 0.157848244209694 EGFR/LRP1/APP/GRN 4 GO:0051450 myoblast proliferation 4/969 25/18722 0.0378943709018802 0.157848244209694 MALAT1/GPX1/ZNF609/PAXBP1 4 GO:0060706 cell differentiation involved in embryonic placenta development 4/969 25/18722 0.0378943709018802 0.157848244209694 KRT19/KRT8/NR2F2/HECTD1 4 GO:0061436 establishment of skin barrier 4/969 25/18722 0.0378943709018802 0.157848244209694 MET/PLEC/CLDN4/STMN1 4 GO:0072012 glomerulus vasculature development 4/969 25/18722 0.0378943709018802 0.157848244209694 EGR1/BMP7/CFLAR/HES1 4 GO:0016072 rRNA metabolic process 19/969 236/18722 0.0379443126207834 0.157848244209694 RPS21/RPL14/RPS6/RPS25/RPL26/RPS8/RPL10A/RPS16/RPL7A/RPL11/PRKDC/RPL27/RPL7/DDX17/RPL35/SNU13/EBNA1BP2/NHP2/NOP10 19 GO:0008286 insulin receptor signaling pathway 11/969 116/18722 0.0379669427806325 0.157848244209694 KANK1/IGF2/IGF1R/PHIP/PTPRA/GAB1/PIK3R1/ZNF106/SORBS1/PTPRE/CAV2 11 GO:0030326 embryonic limb morphogenesis 11/969 116/18722 0.0379669427806325 0.157848244209694 FBN2/PBX1/FRAS1/LRP5/NIPBL/GLI3/TBX3/TFAP2A/MBNL1/BMP7/TMEM107 11 GO:0035113 embryonic appendage morphogenesis 11/969 116/18722 0.0379669427806325 0.157848244209694 FBN2/PBX1/FRAS1/LRP5/NIPBL/GLI3/TBX3/TFAP2A/MBNL1/BMP7/TMEM107 11 GO:1990748 cellular detoxification 11/969 116/18722 0.0379669427806325 0.157848244209694 GPX3/GSTO1/PRDX6/PRDX1/GPX4/GSTP1/GPX1/S100A9/TXN/SOD3/BMP7 11 GO:0031110 regulation of microtubule polymerization or depolymerization 9/969 88/18722 0.038111006171863 0.158195487096232 AKAP9/CLIP1/MET/RPS3/HSPA1A/CAMSAP2/TAOK1/HSPA1B/STMN1 9 GO:0050779 RNA destabilization 9/969 88/18722 0.038111006171863 0.158195487096232 ZFP36L1/ROCK1/PUM1/TNRC6B/TNRC6A/CELF1/AGO2/BTG2/PABPC1 9 GO:0001841 neural tube formation 10/969 102/18722 0.0383340871627903 0.158995190089478 LRP2/PFN1/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/BMP7/CITED2 10 GO:0010951 negative regulation of endopeptidase activity 20/969 252/18722 0.0384875431864536 0.159505075886127 GAPDH/ITIH5/APLP2/APP/CRIM1/SPINT1/SERPINB9/ROCK1/ANXA2/GPX1/BIRC6/USP47/DHCR24/SERPINB1/SERPINH1/SIAH2/SERPINB6/CSTB/TIMP2/PTTG1 20 GO:0043087 regulation of GTPase activity 26/969 348/18722 0.0390891703809436 0.16073083431821 ITGA6/IQGAP2/ITGB1/MET/IQGAP1/RASA1/S100A10/DOCK8/ADRB1/SYDE2/NF1/RABGAP1/RICTOR/CCPG1/AMOT/PLXNB1/DOCK9/GAPVD1/RAB3GAP2/WNK1/EVI5/ARFGEF1/SNX18/CAV2/DYNLT1/STMN1 26 GO:0046683 response to organophosphorus 12/969 131/18722 0.0391087433946422 0.16073083431821 JUN/AKAP9/FOS/LDHA/HSP90B1/FOSB/APP/HSPA5/ZFP36L1/DUSP1/SLC6A4/EZR 12 GO:0019318 hexose metabolic process 19/969 237/18722 0.0393392112531185 0.16073083431821 GAPDH/ALDOA/TPI1/IGF2/ENO1/DDB1/GAA/LRP5/RANBP2/PMAIP1/FUT8/MAN2A1/SORBS1/AKR1B1/MAPK14/EP300/SLC35B4/LCMT1/PGK1 19 GO:0031958 corticosteroid receptor signaling pathway 3/969 15/18722 0.0394525966813439 0.16073083431821 PTGES3/ARID1A/NR3C1 3 GO:0032488 Cdc42 protein signal transduction 3/969 15/18722 0.0394525966813439 0.16073083431821 NRP1/ABCA1/CDC42 3 GO:0035493 SNARE complex assembly 3/969 15/18722 0.0394525966813439 0.16073083431821 UVRAG/VAMP2/VAMP3 3 GO:0042994 cytoplasmic sequestering of transcription factor 3/969 15/18722 0.0394525966813439 0.16073083431821 TMSB4X/NFKBIA/SRI 3 GO:0048569 post-embryonic animal organ development 3/969 15/18722 0.0394525966813439 0.16073083431821 FBN1/LDHA/EFEMP1 3 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 3/969 15/18722 0.0394525966813439 0.16073083431821 NPM1/RAN/XPO1 3 GO:0071474 cellular hyperosmotic response 3/969 15/18722 0.0394525966813439 0.16073083431821 SLC2A1/AKR1B1/EFHD1 3 GO:0071871 response to epinephrine 3/969 15/18722 0.0394525966813439 0.16073083431821 ATP2B4/PDE4B/SLC9A1 3 GO:0090110 COPII-coated vesicle cargo loading 3/969 15/18722 0.0394525966813439 0.16073083431821 MIA3/SEC31A/SEC13 3 GO:0098760 response to interleukin-7 3/969 15/18722 0.0394525966813439 0.16073083431821 YBX1/PDIA3/P4HB 3 GO:0098761 cellular response to interleukin-7 3/969 15/18722 0.0394525966813439 0.16073083431821 YBX1/PDIA3/P4HB 3 GO:1900029 positive regulation of ruffle assembly 3/969 15/18722 0.0394525966813439 0.16073083431821 PFN1/EPS8L1/EPS8 3 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 3/969 15/18722 0.0394525966813439 0.16073083431821 HSPA5/PPP1R15A/UFL1 3 GO:1901841 regulation of high voltage-gated calcium channel activity 3/969 15/18722 0.0394525966813439 0.16073083431821 PDE4B/CALM1/SRI 3 GO:1904424 regulation of GTP binding 3/969 15/18722 0.0394525966813439 0.16073083431821 MET/CCPG1/STMN1 3 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 3/969 15/18722 0.0394525966813439 0.16073083431821 NHP2/CCT8/NOP10 3 GO:1905146 lysosomal protein catabolic process 3/969 15/18722 0.0394525966813439 0.16073083431821 LRP2/LRP1/VPS13A 3 GO:2001028 positive regulation of endothelial cell chemotaxis 3/969 15/18722 0.0394525966813439 0.16073083431821 MET/HSPB1/TMSB4X 3 GO:1902369 negative regulation of RNA catabolic process 8/969 75/18722 0.0396357158715613 0.16073083431821 FUS/YBX1/LARP1/MAPK14/THRAP3/PABPC1/HNRNPC/HNRNPU 8 GO:0042542 response to hydrogen peroxide 13/969 146/18722 0.039752883362497 0.16073083431821 JUN/LDHA/MET/RHOB/RPS3/ANXA1/DUSP1/GPX1/TXN/PAWR/SETX/CDK1/HMOX1 13 GO:0006692 prostanoid metabolic process 6/969 49/18722 0.0397675026355617 0.16073083431821 MIF/ANXA1/GSTP1/PTGES3/AKR1B1/HPGD 6 GO:0006693 prostaglandin metabolic process 6/969 49/18722 0.0397675026355617 0.16073083431821 MIF/ANXA1/GSTP1/PTGES3/AKR1B1/HPGD 6 GO:0009409 response to cold 6/969 49/18722 0.0397675026355617 0.16073083431821 FOS/ATP2B1/ADRB1/SLC9A1/EIF2AK4/NFKBIA 6 GO:0018198 peptidyl-cysteine modification 6/969 49/18722 0.0397675026355617 0.16073083431821 GAPDH/S100A9/ATP2B4/TXN/RAB6A/DMD 6 GO:0030857 negative regulation of epithelial cell differentiation 6/969 49/18722 0.0397675026355617 0.16073083431821 CAV1/TBX3/JAG1/SRSF6/ID1/HES1 6 GO:0035088 establishment or maintenance of apical/basal cell polarity 6/969 49/18722 0.0397675026355617 0.16073083431821 DLG5/DLG1/FAT1/RHOA/CDC42/ARF4 6 GO:0038084 vascular endothelial growth factor signaling pathway 6/969 49/18722 0.0397675026355617 0.16073083431821 NRP2/SEMA6A/CD63/HSPB1/NRP1/GAB1 6 GO:0046580 negative regulation of Ras protein signal transduction 6/969 49/18722 0.0397675026355617 0.16073083431821 ITGB1/MET/KANK1/RASA1/TIMP2/STMN1 6 GO:0061245 establishment or maintenance of bipolar cell polarity 6/969 49/18722 0.0397675026355617 0.16073083431821 DLG5/DLG1/FAT1/RHOA/CDC42/ARF4 6 GO:0043534 blood vessel endothelial cell migration 15/969 176/18722 0.039970095591557 0.161424821917679 ITGB1/EPHB4/ANXA1/HSPB1/MIA3/NRP1/TMSB4X/GPX1/NF1/ATP2B4/CSNK2B/RHOA/AMOT/ID1/HMOX1 15 GO:0014902 myotube differentiation 11/969 117/18722 0.0400337197710226 0.161525473608436 PLEC/GPX1/BHLHE41/MMP14/MAPK14/XBP1/CFLAR/HOMER1/MYOF/KLF5/CAV2 11 GO:0001558 regulation of cell growth 30/969 414/18722 0.0400568338684525 0.161525473608436 EGFR/LRP1/GOLGA4/SEMA6A/MACF1/SEMA6D/GJA1/ENO1/NPM1/NRP1/BTG1/USP47/HSPA1A/KIAA1109/SMARCA2/S100A9/RAB11A/EIF4G1/SLC9A1/RHOA/MMP14/DDX39B/YY1/CLSTN1/VGLL4/RTN4/SPAG9/CDC42/HSPA1B/NDUFA13 30 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 7/969 62/18722 0.0403965696514321 0.162058960028393 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1 7 GO:0031124 mRNA 3'-end processing 7/969 62/18722 0.0403965696514321 0.162058960028393 APP/ZFP36L1/PCF11/AHCYL1/YTHDC1/PABPC1/CCNB1 7 GO:0032623 interleukin-2 production 7/969 62/18722 0.0403965696514321 0.162058960028393 RPS3/ANXA1/SPTBN1/PDE4B/GATA3/EZR/STOML2 7 GO:0032663 regulation of interleukin-2 production 7/969 62/18722 0.0403965696514321 0.162058960028393 RPS3/ANXA1/SPTBN1/PDE4B/GATA3/EZR/STOML2 7 GO:0046847 filopodium assembly 7/969 62/18722 0.0403965696514321 0.162058960028393 ITGB4/NRP1/PPP1R9A/PIK3R1/CDC42/EZR/RAB17 7 GO:0060113 inner ear receptor cell differentiation 7/969 62/18722 0.0403965696514321 0.162058960028393 TRIP11/MCOLN3/TRIOBP/JAG1/RBPJ/NAGLU/HES1 7 GO:0042886 amide transport 23/969 301/18722 0.0405138884201803 0.162058960028393 EGFR/LRP2/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/PSAP/LRP5/PHPT1/KIF5B/SYT7/ABCA1/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/SLC19A1/SLC13A3/SRI 23 GO:0014910 regulation of smooth muscle cell migration 9/969 89/18722 0.0405361717934077 0.162058960028393 LRP1/S100A11/IQGAP1/ADAMTS1/SEMA6D/GSTP1/NRP1/RHOA/GNA12 9 GO:0090277 positive regulation of peptide hormone secretion 10/969 103/18722 0.0405735855610922 0.162058960028393 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/PHPT1/KIF5B/TCF7L2/SRI 10 GO:0006623 protein targeting to vacuole 5/969 37/18722 0.0405922653419759 0.162058960028393 GCC2/VPS13C/ZFYVE16/VPS13A/GNPTAB 5 GO:0043403 skeletal muscle tissue regeneration 5/969 37/18722 0.0405922653419759 0.162058960028393 DAG1/ANXA1/GPX1/CFLAR/KLF5 5 GO:0051567 histone H3-K9 methylation 5/969 37/18722 0.0405922653419759 0.162058960028393 ATRX/ASH1L/RIF1/JARID2/SETD5 5 GO:0062237 protein localization to postsynapse 5/969 37/18722 0.0405922653419759 0.162058960028393 DAG1/DLG1/RAB11A/CLSTN1/VAMP2 5 GO:0072175 epithelial tube formation 12/969 132/18722 0.0410842980004862 0.163898123168352 LRP2/PFN1/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/IRX2/BMP7/CITED2/GATA3 12 GO:0043405 regulation of MAP kinase activity 15/969 177/18722 0.0416759677177507 0.166131660787922 EGFR/CAV1/IQGAP1/RPS3/DUSP1/AKAP13/MAGED1/GSTP1/MAP3K4/NF1/TAOK3/CDK12/BMP7/KRAS/CD24 15 GO:0052548 regulation of endopeptidase activity 31/969 432/18722 0.0417242904046038 0.166197516504923 GAPDH/ITIH5/APLP2/APP/CRIM1/SPINT1/RPS3/SERPINB9/ROCK1/ANXA2/GPX1/BIRC6/PMAIP1/USP47/DHCR24/S100A9/RHOA/ASPH/CTSD/SERPINB1/CFLAR/SERPINH1/SIAH2/PSME2/PDCD6/REST/SERPINB6/CSTB/NDUFA13/TIMP2/PTTG1 31 GO:0051100 negative regulation of binding 14/969 162/18722 0.0418045184501305 0.166390261553985 JUN/CAV1/C4orf3/ROCK1/TMSB4X/PTPRF/RSF1/LRPAP1/NFKBIA/DDIT3/ID1/HMOX1/SRI/AURKA 14 GO:0045861 negative regulation of proteolysis 26/969 351/18722 0.0426434179363297 0.169600077728508 GAPDH/ITIH5/APLP2/LRP1/APP/CRIM1/GLG1/RPL11/SPINT1/SERPINB9/ROCK1/ANXA2/EIF3H/GPX1/BIRC6/USP47/DHCR24/SERPINB1/WAC/SERPINH1/SIAH2/SERPINB6/CSTB/TIMP2/PTTG1/TAF9 26 GO:0021680 cerebellar Purkinje cell layer development 4/969 26/18722 0.0430116612239286 0.169849225094819 HSPA5/RERE/NAGLU/UQCRQ 4 GO:0032515 negative regulation of phosphoprotein phosphatase activity 4/969 26/18722 0.0430116612239286 0.169849225094819 BOD1L1/PPP1R15A/ROCK1/LGALS3 4 GO:0033522 histone H2A ubiquitination 4/969 26/18722 0.0430116612239286 0.169849225094819 DDB1/SKP1/UBR5/UBE2A 4 GO:0034063 stress granule assembly 4/969 26/18722 0.0430116612239286 0.169849225094819 PRRC2C/DYNC1H1/PUM2/ATXN2 4 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 4/969 26/18722 0.0430116612239286 0.169849225094819 SLC39A10/RPS3/KCNN4/FOXP1 4 GO:0060037 pharyngeal system development 4/969 26/18722 0.0430116612239286 0.169849225094819 ISL1/BMP7/GATA3/HES1 4 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 4/969 26/18722 0.0430116612239286 0.169849225094819 AKAP13/ADRB1/ATP2B4/PDE4B 4 GO:0097066 response to thyroid hormone 4/969 26/18722 0.0430116612239286 0.169849225094819 ANXA2/CTSL/AKR1B1/GCLM 4 GO:1904376 negative regulation of protein localization to cell periphery 4/969 26/18722 0.0430116612239286 0.169849225094819 CLTC/HECTD1/PPFIA1/GOPC 4 GO:0046849 bone remodeling 9/969 90/18722 0.043063571230508 0.169849225094819 EGFR/GJA1/LGR4/LRP5/SUCO/NF1/TFRC/SYT7/LTBP3 9 GO:1904705 regulation of vascular associated smooth muscle cell proliferation 9/969 90/18722 0.043063571230508 0.169849225094819 JUN/ADAMTS1/GJA1/GSTP1/RHOA/GNA12/DDX39B/HMOX1/HPGD 9 GO:0046887 positive regulation of hormone secretion 12/969 133/18722 0.043128502863209 0.169977040696177 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/CYP19A1/PHPT1/KIF5B/TCF7L2/TMF1/SRI 12 GO:0050873 brown fat cell differentiation 6/969 50/18722 0.0432924837175859 0.170366355352488 ADRB1/BMP7/MAPK14/RREB1/ARL4A/HNRNPU 6 GO:0060425 lung morphogenesis 6/969 50/18722 0.0432924837175859 0.170366355352488 DAG1/DLG5/NFIB/CDC42/SRSF6/KRAS 6 GO:0032233 positive regulation of actin filament bundle assembly 7/969 63/18722 0.0435025391101802 0.170935540894588 PFN1/S100A10/NRP1/RHOA/CDC42/ID1/RHOC 7 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 7/969 63/18722 0.0435025391101802 0.170935540894588 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1 7 GO:0035148 tube formation 13/969 148/18722 0.0435818681544854 0.171118589763592 LRP2/PFN1/SPINT1/LMO4/SOX4/BRD2/HECTD1/SETD2/IRX2/NFIB/BMP7/CITED2/GATA3 13 GO:0071496 cellular response to external stimulus 24/969 320/18722 0.0443547641167249 0.174022520475979 JUN/EGFR/FOS/ATP2B1/DAG1/HSPA5/SLC2A1/GJA1/PLEC/GSTP1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/TMEM150C/EIF4G1/SLC9A1/CTSV/EIF2AK4/XBP1/ITFG2/TRIM24/HMOX1/DNAJC15 24 GO:0010613 positive regulation of cardiac muscle hypertrophy 5/969 38/18722 0.0448281746292174 0.175222169493112 IL6ST/ROCK1/PARP1/SLC9A1/DDX39B 5 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 5/969 38/18722 0.0448281746292174 0.175222169493112 ISL1/RHOA/NCOR1/FOXP1/LBH 5 GO:0042491 inner ear auditory receptor cell differentiation 5/969 38/18722 0.0448281746292174 0.175222169493112 MCOLN3/TRIOBP/JAG1/RBPJ/HES1 5 GO:0042596 fear response 5/969 38/18722 0.0448281746292174 0.175222169493112 GJA1/ADRB1/EIF4G1/DPP4/VDAC1 5 GO:2000279 negative regulation of DNA biosynthetic process 5/969 38/18722 0.0448281746292174 0.175222169493112 GJA1/DUSP1/HNRNPA1/HNRNPC/HNRNPU 5 GO:0042552 myelination 12/969 134/18722 0.0452422925619279 0.176708685297934 ITGB4/DAG1/PLEC/CTSC/DLG1/JAM3/NF1/DICER1/GPC1/B4GALT5/QKI/AFG3L2 12 GO:2001022 positive regulation of response to DNA damage stimulus 10/969 105/18722 0.0453178921559903 0.176871773269011 EGFR/FUS/RPL26/PRKDC/DDX5/RPS3/RIF1/PARP1/BCLAF1/PMAIP1 10 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 14/969 164/18722 0.0455601074379344 0.177684419007944 CAV1/RPL11/EIF3H/UFL1/HECTD1/HSPA1A/DDA1/GNA12/WAC/XPO1/HSPA1B/CDC20/TAF9/AURKA 14 GO:1990874 vascular associated smooth muscle cell proliferation 9/969 91/18722 0.0456946192155634 0.178076122312106 JUN/ADAMTS1/GJA1/GSTP1/RHOA/GNA12/DDX39B/HMOX1/HPGD 9 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 3/969 16/18722 0.0467402495629649 0.18047246999362 ENPEP/MME/ATP6AP2 3 GO:0003084 positive regulation of systemic arterial blood pressure 3/969 16/18722 0.0467402495629649 0.18047246999362 NR2F2/RHOA/WNK1 3 GO:0009048 dosage compensation by inactivation of X chromosome 3/969 16/18722 0.0467402495629649 0.18047246999362 YTHDC1/CDYL/HNRNPU 3 GO:0032274 gonadotropin secretion 3/969 16/18722 0.0467402495629649 0.18047246999362 GJA1/TBX3/TMF1 3 GO:0051014 actin filament severing 3/969 16/18722 0.0467402495629649 0.18047246999362 CFL1/SCIN/SVIL 3 GO:0051238 sequestering of metal ion 3/969 16/18722 0.0467402495629649 0.18047246999362 FTH1/S100A9/SRI 3 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 3/969 16/18722 0.0467402495629649 0.18047246999362 HSPA1A/NFKBIA/HSPA1B 3 GO:0072109 glomerular mesangium development 3/969 16/18722 0.0467402495629649 0.18047246999362 EGR1/BMP7/CFLAR 3 GO:0072148 epithelial cell fate commitment 3/969 16/18722 0.0467402495629649 0.18047246999362 NR2F2/NRP1/RBPJ 3 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 3/969 16/18722 0.0467402495629649 0.18047246999362 RAB11A/CLSTN1/VAMP2 3 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3/969 16/18722 0.0467402495629649 0.18047246999362 RPL26/MIF/TAF9 3 GO:2001224 positive regulation of neuron migration 3/969 16/18722 0.0467402495629649 0.18047246999362 SEMA6A/NIPBL/ZNF609 3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 7/969 64/18722 0.0467584623749256 0.18047246999362 LRP1/DYNLL1/LRP5/PHPT1/KIF5B/HMGN3/SRI 7 GO:0002790 peptide secretion 19/969 242/18722 0.046879059292391 0.180804401374196 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/PHPT1/KIF5B/SYT7/ABCA1/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/SRI 19 GO:0021872 forebrain generation of neurons 6/969 51/18722 0.0470071301270384 0.18103114373169 NRP2/NRP1/GLI3/RHOA/UQCRQ/HES1 6 GO:0046850 regulation of bone remodeling 6/969 51/18722 0.0470071301270384 0.18103114373169 EGFR/SUCO/NF1/TFRC/SYT7/LTBP3 6 GO:0048660 regulation of smooth muscle cell proliferation 15/969 180/18722 0.0471035545717621 0.1812689073579 JUN/EGFR/SF1/ADAMTS1/PRKDC/GJA1/GSTP1/RHOA/GNA12/FOXP1/TCF7L2/AKR1B1/DDX39B/HMOX1/HPGD 15 GO:0050807 regulation of synapse organization 17/969 211/18722 0.0473912063341666 0.182241680870018 NRP2/APP/DAG1/CFL1/DLG5/PPP1R9A/EIF4G1/RHOA/MAPK14/SETD5/CLSTN1/HOMER1/CDC42/TPBG/RAB17/ARF4/CDC20 17 GO:0050796 regulation of insulin secretion 14/969 165/18722 0.0475239074322908 0.182617603118494 LRP1/DYNLL1/GJA1/SOX4/ISL1/LRP5/PHPT1/KIF5B/SYT7/TCF7L2/HMGN3/DPP4/REST/SRI 14 GO:0002062 chondrocyte differentiation 10/969 106/18722 0.0478250817058026 0.183370415990113 GLG1/TRIP11/GLI3/EFEMP1/SCIN/CREB3L2/NFIB/LTBP3/MAPK14/SERPINH1 10 GO:0002793 positive regulation of peptide secretion 10/969 106/18722 0.0478250817058026 0.183370415990113 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/PHPT1/KIF5B/TCF7L2/SRI 10 GO:0035821 modulation of process of other organism 10/969 106/18722 0.0478250817058026 0.183370415990113 JUN/DAG1/CFL1/SERPINB9/S100A9/EP300/EIF2AK4/RXRA/REST/CAV2 10 GO:0034637 cellular carbohydrate biosynthetic process 8/969 78/18722 0.0482263589117052 0.184638059833386 IGF2/AGL/PTGES3/SORBS1/AKR1B1/B4GALT5/UGP2/B3GNT2 8 GO:0070373 negative regulation of ERK1 and ERK2 cascade 8/969 78/18722 0.0482263589117052 0.184638059833386 SEMA6A/FBLN1/EIF3A/DUSP6/DUSP1/DLG1/GSTP1/EZR 8 GO:0008053 mitochondrial fusion 4/969 27/18722 0.0484978418117461 0.184864858722236 HUWE1/TFRC/AFG3L2/STOML2 4 GO:0010586 miRNA metabolic process 4/969 27/18722 0.0484978418117461 0.184864858722236 KCNQ1OT1/DDX17/DICER1/AGO2 4 GO:0031954 positive regulation of protein autophosphorylation 4/969 27/18722 0.0484978418117461 0.184864858722236 IQGAP1/RAD50/CALM1/CALM2 4 GO:0033561 regulation of water loss via skin 4/969 27/18722 0.0484978418117461 0.184864858722236 MET/PLEC/CLDN4/STMN1 4 GO:0033688 regulation of osteoblast proliferation 4/969 27/18722 0.0484978418117461 0.184864858722236 ITGAV/LRP5/RHOA/PLXNB1 4 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 4/969 27/18722 0.0484978418117461 0.184864858722236 PARP1/HNRNPA1/HNRNPC/HNRNPU 4 GO:0045862 positive regulation of proteolysis 27/969 372/18722 0.0485967428684379 0.185106835444939 CAV1/APP/FBLN1/GRN/ENO1/RPS3/CTSC/CLDN4/HECTD1/PMAIP1/HSPA1A/DDA1/S100A9/RHOA/ASPH/CTSD/MMP14/CFLAR/TMEM259/PSME2/PDCD6/REST/HSPA1B/NDUFA13/CDC20/PSMC1/AURKA 27 GO:0006816 calcium ion transport 30/969 422/18722 0.0492987456459604 0.187444886109006 TPT1/AHNAK/ATP2B1/CAV1/ITGAV/C4orf3/GSTO1/GJA1/ANXA2/DIAPH1/KCNN4/ATP2B4/PDE4B/SLC9A1/RHOA/MCOLN3/TRPV6/LGALS3/DMD/CALM1/SLC3A2/DDIT3/HOMER1/CAMK2G/AFG3L2/YWHAE/VDAC1/CALM2/SRI/STOML2 30 GO:0014742 positive regulation of muscle hypertrophy 5/969 39/18722 0.0493181627248151 0.187444886109006 IL6ST/ROCK1/PARP1/SLC9A1/DDX39B 5 GO:0016572 histone phosphorylation 5/969 39/18722 0.0493181627248151 0.187444886109006 BAZ1B/RPS6KA5/CDK1/CCNB1/AURKA 5 GO:0030307 positive regulation of cell growth 14/969 166/18722 0.0495459572892073 0.188173817437062 EGFR/LRP1/GOLGA4/MACF1/NRP1/USP47/S100A9/RAB11A/EIF4G1/SLC9A1/RHOA/MMP14/DDX39B/CDC42 14 GO:0007272 ensheathment of neurons 12/969 136/18722 0.0496821532095909 0.188280589320756 ITGB4/DAG1/PLEC/CTSC/DLG1/JAM3/NF1/DICER1/GPC1/B4GALT5/QKI/AFG3L2 12 GO:0008366 axon ensheathment 12/969 136/18722 0.0496821532095909 0.188280589320756 ITGB4/DAG1/PLEC/CTSC/DLG1/JAM3/NF1/DICER1/GPC1/B4GALT5/QKI/AFG3L2 12 GO:0043624 cellular protein complex disassembly 12/969 136/18722 0.0496821532095909 0.188280589320756 CFL1/SCIN/SPTBN1/SPTAN1/CAMSAP2/SVIL/TRIOBP/TAOK1/EIF5A/EPS8/ADD3/STMN1 12 GO:0071333 cellular response to glucose stimulus 13/969 151/18722 0.0497974013342461 0.18844404009614 LRP1/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/CCDC186/XBP1/HMGN3/GCLM/SRI 13 GO:1904064 positive regulation of cation transmembrane transport 13/969 151/18722 0.0497974013342461 0.18844404009614 AKAP9/GSTO1/ANK3/TMSB4X/KIF5B/KCNN4/SLC9A1/DMD/CALM1/WNK1/ACTN4/CALM2/SRI 13 GO:0010952 positive regulation of peptidase activity 16/969 197/18722 0.0501453941531222 0.188750195886542 CAV1/APP/FBLN1/GRN/RPS3/CLDN4/PMAIP1/S100A9/RHOA/ASPH/CTSD/CFLAR/PSME2/PDCD6/REST/NDUFA13 16 GO:0033692 cellular polysaccharide biosynthetic process 7/969 65/18722 0.0501659647109373 0.188750195886542 IGF2/AGL/PTGES3/SORBS1/B4GALT5/UGP2/B3GNT2 7 GO:0035418 protein localization to synapse 7/969 65/18722 0.0501659647109373 0.188750195886542 DAG1/HSPB1/DLG1/KIF5B/RAB11A/CLSTN1/VAMP2 7 GO:0044784 metaphase/anaphase transition of cell cycle 7/969 65/18722 0.0501659647109373 0.188750195886542 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1 7 GO:0048645 animal organ formation 7/969 65/18722 0.0501659647109373 0.188750195886542 LRP2/ISL1/GLI3/BMP7/RBPJ/CITED2/HES1 7 GO:0070936 protein K48-linked ubiquitination 7/969 65/18722 0.0501659647109373 0.188750195886542 TTC3/TRIM44/PPIA/SKP1/UBR5/UBE2C/UBE2A 7 GO:1905330 regulation of morphogenesis of an epithelium 7/969 65/18722 0.0501659647109373 0.188750195886542 GJA1/LGR4/MAGED1/FOXP1/BMP7/TACSTD2/GATA3 7 GO:0006898 receptor-mediated endocytosis 19/969 244/18722 0.0501672449457343 0.188750195886542 LRP2/LRP1/CAV1/ITGAV/AAK1/ITGB1/CD63/ANXA2/CLTC/CTSL/TFRC/AHI1/CLTA/LRPAP1/ATXN2/AP2A2/EZR/CLTB/CAV2 19 GO:0051091 positive regulation of DNA-binding transcription factor activity 20/969 260/18722 0.0503801346626618 0.18941480845113 CAV1/APP/RPS3/PLPP3/NPM1/LRP5/PPIA/ERC1/HSPA1A/S100A9/TFRC/RPS6KA5/EP300/ARID5B/CFLAR/DDIT3/FLOT2/HSPA1B/KRAS/ANXA3 20 GO:0021761 limbic system development 10/969 107/18722 0.0504237559774578 0.189442522457365 NRP2/CDK6/NRP1/KIF5B/GLI3/TBX3/ATP2B4/UQCRQ/BTG2/ANXA3 10 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 6/969 52/18722 0.0509131258115199 0.191006457638911 PLPP3/COPA/RAB6A/UVRAG/ARF4/KDELR2 6 GO:0032206 positive regulation of telomere maintenance 6/969 52/18722 0.0509131258115199 0.191006457638911 ATRX/PPP1R10/MAP3K4/RAD50/HNRNPA1/CCT8 6 GO:0060401 cytosolic calcium ion transport 15/969 182/18722 0.0509865857380335 0.19114483290313 ATP2B1/CAV1/GSTO1/DIAPH1/ATP2B4/MCOLN3/TRPV6/DMD/CALM1/DDIT3/AFG3L2/YWHAE/VDAC1/CALM2/SRI 15 GO:0090398 cellular senescence 9/969 93/18722 0.0512727899776728 0.192080000303454 PRKDC/CDK6/YBX1/TBX3/PAWR/HMGA1/MAPK14/NEK6/KRAS 9 GO:0071695 anatomical structure maturation 18/969 229/18722 0.051526938224604 0.192893824614456 APP/DAG1/RERE/FERMT1/EPAS1/RHOA/PLXNB1/ANKRD17/AKR1B1/B4GALT5/RBPJ/TFCP2L1/DDIT3/ATP6AP2/GATA3/HES1/CCNB1/AURKA 18 GO:0006814 sodium ion transport 19/969 245/18722 0.0518713822857639 0.193905467686268 UTRN/SLC38A1/ANK3/DLG1/SLC38A2/KIF5B/ATP2B4/SLC5A3/SLC9A1/SLC13A4/SLC38A10/DMD/WNK1/SLC6A4/AHCYL1/ACTN4/SLC3A2/MAGED2/SLC13A3 19 GO:0098656 anion transmembrane transport 19/969 245/18722 0.0518713822857639 0.193905467686268 TCAF1/LRP2/SLC26A2/ITGB1/GJA1/GABRE/SLC16A12/SLC9A1/SLC1A5/SLC13A4/PCYOX1/SLC25A6/SLC3A2/SLC35B4/GOPC/SLC19A1/VDAC1/SLC13A3/VDAC2 19 GO:0030509 BMP signaling pathway 13/969 152/18722 0.0519981721397565 0.19414544160591 FBN1/LRP2/CRIM1/DDX5/TGFBR3/EGR1/USP9X/TRIM33/SMAD5/BMP7/RBPJ/HTRA1/HES1 13 GO:0055123 digestive system development 12/969 137/18722 0.0520098772002054 0.19414544160591 EGFR/WLS/IGF2/LGR4/IL6ST/NIPBL/GLI3/AHI1/CHD8/KLF5/HES1/CCNB1 12 GO:0031668 cellular response to extracellular stimulus 19/969 246/18722 0.053616083035018 0.199262272143194 JUN/FOS/ATP2B1/HSPA5/SLC2A1/PLEC/GSTP1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/EIF4G1/CTSV/EIF2AK4/XBP1/ITFG2/TRIM24/HMOX1/DNAJC15 19 GO:0050922 negative regulation of chemotaxis 7/969 66/18722 0.0537264259540225 0.199262272143194 SEMA6A/MIF/SEMA6D/DUSP1/GSTP1/NRP1/DPP4 7 GO:1902806 regulation of cell cycle G1/S phase transition 14/969 168/18722 0.0537673756372331 0.199262272143194 EGFR/RPL26/ADAMTS1/PRKDC/SOX4/ANXA1/DLG1/CTDSPL/ATP2B4/BRD7/EIF4G1/ANKRD17/WAC/PSME2 14 GO:2000142 regulation of DNA-templated transcription, initiation 5/969 40/18722 0.0540631422915257 0.199262272143194 JUN/BCLAF1/ZNF451/SETX/MED13 5 GO:0050852 T cell receptor signaling pathway 11/969 123/18722 0.0540830598132091 0.199262272143194 RPS3/PHPT1/KCNN4/PDE4B/LGALS3/PAWR/WNK1/SPPL3/GATA3/EZR/STOML2 11 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 9/969 94/18722 0.0542222038363822 0.199262272143194 EGFR/CCNL1/NR2F2/LATS2/SERTAD1/CKS1B/CDKN3/CCNB1/CCNE1 9 GO:0014020 primary neural tube formation 9/969 94/18722 0.0542222038363822 0.199262272143194 LRP2/PFN1/SPINT1/LMO4/BRD2/HECTD1/SETD2/BMP7/CITED2 9 GO:0030316 osteoclast differentiation 9/969 94/18722 0.0542222038363822 0.199262272143194 FBN1/FOS/ANXA2/TFRC/PIK3R1/JUNB/FOXP1/ESRRA/MAPK14 9 GO:0051702 biological process involved in interaction with symbiont 9/969 94/18722 0.0542222038363822 0.199262272143194 GAPDH/JUN/CFL1/DDB1/GPX1/EP300/EIF2AK4/REST/CAV2 9 GO:0071331 cellular response to hexose stimulus 13/969 153/18722 0.0542645715932436 0.199262272143194 LRP1/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/CCDC186/XBP1/HMGN3/GCLM/SRI 13 GO:0007064 mitotic sister chromatid cohesion 4/969 28/18722 0.0543512106028536 0.199262272143194 ATRX/NIPBL/PDS5A/CDC20 4 GO:0031440 regulation of mRNA 3'-end processing 4/969 28/18722 0.0543512106028536 0.199262272143194 ZFP36L1/AHCYL1/YTHDC1/CCNB1 4 GO:0051894 positive regulation of focal adhesion assembly 4/969 28/18722 0.0543512106028536 0.199262272143194 IQGAP1/S100A10/ROCK1/NRP1 4 GO:0060325 face morphogenesis 4/969 28/18722 0.0543512106028536 0.199262272143194 ANKRD11/NIPBL/EP300/ARID5B 4 GO:0060765 regulation of androgen receptor signaling pathway 4/969 28/18722 0.0543512106028536 0.199262272143194 DDX5/NCOR1/FOXP1/EP300 4 GO:0070076 histone lysine demethylation 4/969 28/18722 0.0543512106028536 0.199262272143194 KDM5A/KDM5B/JMJD1C/KDM2A 4 GO:0090344 negative regulation of cell aging 4/969 28/18722 0.0543512106028536 0.199262272143194 MIF/PRKDC/CDK6/YBX1 4 GO:1990776 response to angiotensin 4/969 28/18722 0.0543512106028536 0.199262272143194 CAV1/IQGAP1/ROCK1/AHCYL1 4 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 12/969 138/18722 0.0544104892467003 0.199262272143194 CAV1/HSPA5/RPS2/MYCBP2/NPM1/SKP1/HUWE1/UBE2C/UBE2L3/PDCD6/PTTG1IP/CDC20 12 GO:0120193 tight junction organization 8/969 80/18722 0.0545776561770536 0.199262272143194 SVEP1/ACTG1/GJA1/PLEC/DLG1/ROCK1/CLDN4/CLDN7 8 GO:0001780 neutrophil homeostasis 3/969 17/18722 0.05463888939556 0.199262272143194 ANXA1/JAM3/PDE4B 3 GO:0016264 gap junction assembly 3/969 17/18722 0.05463888939556 0.199262272143194 CAV1/GJA1/GJA5 3 GO:0036035 osteoclast development 3/969 17/18722 0.05463888939556 0.199262272143194 FBN1/ANXA2/FOXP1 3 GO:0045198 establishment of epithelial cell apical/basal polarity 3/969 17/18722 0.05463888939556 0.199262272143194 FAT1/RHOA/CDC42 3 GO:0045815 positive regulation of gene expression, epigenetic 3/969 17/18722 0.05463888939556 0.199262272143194 ARID1A/SERTAD1/EP300 3 GO:0046827 positive regulation of protein export from nucleus 3/969 17/18722 0.05463888939556 0.199262272143194 TPR/TCF7L2/YWHAE 3 GO:0061450 trophoblast cell migration 3/969 17/18722 0.05463888939556 0.199262272143194 ITGB4/GJA1/AGO2 3 GO:0072673 lamellipodium morphogenesis 3/969 17/18722 0.05463888939556 0.199262272143194 KANK1/WASF2/RREB1 3 GO:0090083 regulation of inclusion body assembly 3/969 17/18722 0.05463888939556 0.199262272143194 HSPA1A/DNAJB1/HSPA1B 3 GO:0090136 epithelial cell-cell adhesion 3/969 17/18722 0.05463888939556 0.199262272143194 DSP/VCL/ITGB5 3 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 3/969 17/18722 0.05463888939556 0.199262272143194 NFIB/YY1/REST 3 GO:1903540 establishment of protein localization to postsynaptic membrane 3/969 17/18722 0.05463888939556 0.199262272143194 RAB11A/CLSTN1/VAMP2 3 GO:2000811 negative regulation of anoikis 3/969 17/18722 0.05463888939556 0.199262272143194 CAV1/ITGB1/MCL1 3 GO:0008347 glial cell migration 6/969 53/18722 0.0550117482578451 0.200202922280988 LRP1/LAMB1/ADGRG1/GLI3/MMP14/RTN4 6 GO:0031279 regulation of cyclase activity 6/969 53/18722 0.0550117482578451 0.200202922280988 AKAP9/NF1/CALM1/MAPK14/CALM2/TIMP2 6 GO:1903202 negative regulation of oxidative stress-induced cell death 6/969 53/18722 0.0550117482578451 0.200202922280988 MET/HSPB1/PPIA/GPX1/TXN/REST 6 GO:0048659 smooth muscle cell proliferation 15/969 184/18722 0.0550868153856209 0.20033660209134 JUN/EGFR/SF1/ADAMTS1/PRKDC/GJA1/GSTP1/RHOA/GNA12/FOXP1/TCF7L2/AKR1B1/DDX39B/HMOX1/HPGD 15 GO:0071326 cellular response to monosaccharide stimulus 13/969 154/18722 0.0565972431498046 0.20568650396445 LRP1/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/CCDC186/XBP1/HMGN3/GCLM/SRI 13 GO:0050870 positive regulation of T cell activation 17/969 216/18722 0.0566749187972142 0.205825660621433 CAV1/CD46/IGF2/RPS3/SOX4/ANXA1/IL6ST/DOCK8/GLI3/TFRC/RHOA/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 17 GO:0016579 protein deubiquitination 12/969 139/18722 0.0568846992262493 0.206444054275263 USP34/USP47/USP9X/USP22/USP10/USP27X/USP53/USP48/EIF3F/USP8/CDK1/UCHL3 12 GO:0015833 peptide transport 20/969 264/18722 0.0572196511630628 0.207515542663544 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/PHPT1/KIF5B/SYT7/ABCA1/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/SLC13A3/SRI 20 GO:0008585 female gonad development 9/969 95/18722 0.0572798433370802 0.207589778973357 HSPA5/ADAMTS1/NR2F2/CYP19A1/NRIP1/MMP14/ZFX/ARID5B/IDH1 9 GO:0042490 mechanoreceptor differentiation 7/969 67/18722 0.0574409779136423 0.207885422837046 TRIP11/MCOLN3/TRIOBP/JAG1/RBPJ/NAGLU/HES1 7 GO:0061077 chaperone-mediated protein folding 7/969 67/18722 0.0574409779136423 0.207885422837046 HSPA5/HSPB1/PTGES3/HSPA1A/DNAJB1/DNAJB14/HSPA1B 7 GO:0071260 cellular response to mechanical stimulus 8/969 81/18722 0.0579441881547309 0.209561472177594 EGFR/DAG1/SLC2A1/GJA1/PLEC/SLC38A2/TMEM150C/SLC9A1 8 GO:0007596 blood coagulation 17/969 217/18722 0.0586729234615029 0.212050275248834 F5/CAV1/ACTG1/FBLN1/LMAN1/HSPB1/IL6ST/ANXA2/PPIA/GNAQ/TLN1/MYL12A/JMJD1C/GNA12/CLIC1/VCL/MAPK14 17 GO:0001953 negative regulation of cell-matrix adhesion 5/969 41/18722 0.0590632938315095 0.212701610550203 LRP1/RASA1/PIK3R1/JAG1/MMP14 5 GO:0070296 sarcoplasmic reticulum calcium ion transport 5/969 41/18722 0.0590632938315095 0.212701610550203 GSTO1/DMD/CALM1/CALM2/SRI 5 GO:0071470 cellular response to osmotic stress 5/969 41/18722 0.0590632938315095 0.212701610550203 ZFP36L1/SLC2A1/AKR1B1/EFHD1/SERPINB6 5 GO:1901385 regulation of voltage-gated calcium channel activity 5/969 41/18722 0.0590632938315095 0.212701610550203 AHNAK/PDE4B/DMD/CALM1/SRI 5 GO:1905314 semi-lunar valve development 5/969 41/18722 0.0590632938315095 0.212701610550203 ROCK1/JAG1/GJA5/RBPJ/GATA3 5 GO:0046883 regulation of hormone secretion 19/969 249/18722 0.0590973475925936 0.212701610550203 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/CYP19A1/PHPT1/KIF5B/KDM5B/SYT7/TCF7L2/HMGN3/DPP4/TMF1/REST/SRI 19 GO:0051053 negative regulation of DNA metabolic process 11/969 125/18722 0.0594165699496676 0.213703368587036 GJA1/RPS3/DUSP1/RIF1/PARP1/RAD50/HNRNPA1/UBR5/GATA3/HNRNPC/HNRNPU 11 GO:0060249 anatomical structure homeostasis 23/969 314/18722 0.0596872355113134 0.21452922474699 EGFR/ALDOA/ATP2B1/LAMC1/ITGB1/ACTG1/SLC2A1/GJA1/PRDX1/HSPB1/GAA/JAM3/NF1/TFRC/GCNT2/EPAS1/AKR1B1/DMD/TAOK1/LTBP3/VCL/HOMER1/KRAS 23 GO:0003073 regulation of systemic arterial blood pressure 9/969 96/18722 0.0604465696258801 0.215767786149192 GJA1/ENPEP/NR2F2/ADRB1/RHOA/WNK1/GJA5/MME/ATP6AP2 9 GO:0021522 spinal cord motor neuron differentiation 4/969 29/18722 0.0605685691314323 0.215767786149192 LMO4/SOX4/ISL1/GLI3 4 GO:0032366 intracellular sterol transport 4/969 29/18722 0.0605685691314323 0.215767786149192 ANXA2/SYT7/ABCA1/NPC2 4 GO:0032367 intracellular cholesterol transport 4/969 29/18722 0.0605685691314323 0.215767786149192 ANXA2/SYT7/ABCA1/NPC2 4 GO:0035066 positive regulation of histone acetylation 4/969 29/18722 0.0605685691314323 0.215767786149192 ISL1/BRD7/RPS6KA5/GATA3 4 GO:0040018 positive regulation of multicellular organism growth 4/969 29/18722 0.0605685691314323 0.215767786149192 IGF2/NIPBL/CELF1/EZR 4 GO:0050686 negative regulation of mRNA processing 4/969 29/18722 0.0605685691314323 0.215767786149192 NPM1/SRSF7/SAP18/SRSF6 4 GO:0060969 negative regulation of gene silencing 4/969 29/18722 0.0605685691314323 0.215767786149192 NEAT1/KCNQ1OT1/NCOR1/ADAR 4 GO:0070979 protein K11-linked ubiquitination 4/969 29/18722 0.0605685691314323 0.215767786149192 ANAPC11/UBE2C/UBE2L3/UBE2A 4 GO:0071549 cellular response to dexamethasone stimulus 4/969 29/18722 0.0605685691314323 0.215767786149192 EGFR/NR3C1/CFLAR/USP8 4 GO:0090114 COPII-coated vesicle budding 4/969 29/18722 0.0605685691314323 0.215767786149192 MIA3/SEC31A/PDCD6/SEC13 4 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 4/969 29/18722 0.0605685691314323 0.215767786149192 TPT1/MIF/USP47/TAF9 4 GO:2000406 positive regulation of T cell migration 4/969 29/18722 0.0605685691314323 0.215767786149192 APP/DOCK8/RHOA/WNK1 4 GO:0050803 regulation of synapse structure or activity 17/969 218/18722 0.0607190026479215 0.216156340489127 NRP2/APP/DAG1/CFL1/DLG5/PPP1R9A/EIF4G1/RHOA/MAPK14/SETD5/CLSTN1/HOMER1/CDC42/TPBG/RAB17/ARF4/CDC20 17 GO:0060560 developmental growth involved in morphogenesis 18/969 234/18722 0.0609684508339 0.216896612701131 NRP2/LRP1/GOLGA4/SEMA6A/APP/ITGB1/MACF1/IQGAP1/SEMA6D/NRP1/USP9X/KDM5B/RAB11A/VCL/EIF2AK4/RTN4/SPAG9/AURKA 18 GO:0051926 negative regulation of calcium ion transport 7/969 68/18722 0.0613105026699323 0.217668944940942 C4orf3/GSTO1/CALM1/YWHAE/VDAC1/CALM2/SRI 7 GO:1901016 regulation of potassium ion transmembrane transporter activity 7/969 68/18722 0.0613105026699323 0.217668944940942 AKAP9/CAV1/ITGB1/ANK3/DLG1/VAMP2/YWHAE 7 GO:1904888 cranial skeletal system development 7/969 68/18722 0.0613105026699323 0.217668944940942 NIPBL/SETD2/GLI3/TFAP2A/FOXN3/MMP14/TMEM107 7 GO:0009205 purine ribonucleoside triphosphate metabolic process 8/969 82/18722 0.0614392035846768 0.217829903618399 ALDOA/ENO1/TMSB4X/PARP1/RAN/RHOA/STOML2/IMPDH2 8 GO:0016575 histone deacetylation 8/969 82/18722 0.0614392035846768 0.217829903618399 NIPBL/KDM5A/MORF4L2/TBL1X/RCOR1/BAZ2A/REST/SFPQ 8 GO:0030183 B cell differentiation 12/969 141/18722 0.0620565064580889 0.219571633547713 ZFP36L1/ITGB1/PRKDC/PIK3R1/MMP14/YY1/EP300/XBP1/ITFG2/RBPJ/IRF2BP2/TPD52 12 GO:0035296 regulation of tube diameter 12/969 141/18722 0.0620565064580889 0.219571633547713 EGFR/ATP2B1/CAV1/GJA1/ROCK1/GPX1/ADRB1/RHOA/SOD3/SLC6A4/GJA5/GCLM 12 GO:0097746 blood vessel diameter maintenance 12/969 141/18722 0.0620565064580889 0.219571633547713 EGFR/ATP2B1/CAV1/GJA1/ROCK1/GPX1/ADRB1/RHOA/SOD3/SLC6A4/GJA5/GCLM 12 GO:0001678 cellular glucose homeostasis 14/969 172/18722 0.0629357841649981 0.221862064303642 LRP1/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/PIK3R1/CCDC186/XBP1/HMGN3/GCLM/SRI 14 GO:0003128 heart field specification 3/969 18/18722 0.0631283753577336 0.221862064303642 LRP2/ISL1/RBPJ 3 GO:0007549 dosage compensation 3/969 18/18722 0.0631283753577336 0.221862064303642 YTHDC1/CDYL/HNRNPU 3 GO:0030728 ovulation 3/969 18/18722 0.0631283753577336 0.221862064303642 ADAMTS1/NRIP1/HPGD 3 GO:0036499 PERK-mediated unfolded protein response 3/969 18/18722 0.0631283753577336 0.221862064303642 HSPA5/PPP1R15A/DDIT3 3 GO:0048268 clathrin coat assembly 3/969 18/18722 0.0631283753577336 0.221862064303642 CLTC/CLTA/CLTB 3 GO:0060716 labyrinthine layer blood vessel development 3/969 18/18722 0.0631283753577336 0.221862064303642 JUNB/RBPJ/HES1 3 GO:0061484 hematopoietic stem cell homeostasis 3/969 18/18722 0.0631283753577336 0.221862064303642 ADGRG1/SOX4/ADAR 3 GO:0098877 neurotransmitter receptor transport to plasma membrane 3/969 18/18722 0.0631283753577336 0.221862064303642 RAB11A/CLSTN1/VAMP2 3 GO:1904872 regulation of telomerase RNA localization to Cajal body 3/969 18/18722 0.0631283753577336 0.221862064303642 NHP2/CCT8/NOP10 3 GO:0014909 smooth muscle cell migration 9/969 97/18722 0.0637231265376033 0.2234358681426 LRP1/S100A11/IQGAP1/ADAMTS1/SEMA6D/GSTP1/NRP1/RHOA/GNA12 9 GO:0016050 vesicle organization 22/969 300/18722 0.0637469556874496 0.2234358681426 CAV1/ANXA1/S100A10/ANXA2/MIA3/EEA1/KIF5B/ZFYVE16/HOOK2/SYT7/SEC31A/RAB11A/ABCA1/HOOK3/USP8/TMF1/UVRAG/PDCD6/VAMP2/CAV2/VAMP3/SEC13 22 GO:0003179 heart valve morphogenesis 6/969 55/18722 0.0637899569974662 0.2234358681426 SOX4/ROCK1/JAG1/MDM4/GJA5/GATA3 6 GO:0006414 translational elongation 6/969 55/18722 0.0637899569974662 0.2234358681426 EEF1A1/RPLP1/EEF1B2/NEMF/EIF5A/EEF1D 6 GO:0043331 response to dsRNA 6/969 55/18722 0.0637899569974662 0.2234358681426 CAV1/NPM1/PMAIP1/COLEC12/NFKBIA/SLC3A2 6 GO:0007034 vacuolar transport 13/969 157/18722 0.0639987388608549 0.223867074489175 LRP1/RHOB/GRN/PSAP/GCC2/VPS13C/HSPA1A/ZFYVE16/HOOK2/VPS13A/GNPTAB/HGSNAT/HOOK3 13 GO:1990845 adaptive thermogenesis 13/969 157/18722 0.0639987388608549 0.223867074489175 CAV1/DYNC1H1/GJA1/LGR4/IGF1R/ADRB1/PRLR/EPAS1/ESRRG/RBPJ/DDIT3/ID1/HNRNPU 13 GO:0014912 negative regulation of smooth muscle cell migration 5/969 42/18722 0.0643180838236383 0.224233693170336 LRP1/SEMA6D/GSTP1/RHOA/GNA12 5 GO:0016601 Rac protein signal transduction 5/969 42/18722 0.0643180838236383 0.224233693170336 WASF2/HACD3/EPS8/KRAS/DYNLT1 5 GO:0021795 cerebral cortex cell migration 5/969 42/18722 0.0643180838236383 0.224233693170336 LAMB1/ADGRG1/GLI3/RHOA/RTN4 5 GO:0045687 positive regulation of glial cell differentiation 5/969 42/18722 0.0643180838236383 0.224233693170336 DAG1/SPINT1/IL6ST/DICER1/HES1 5 GO:0045773 positive regulation of axon extension 5/969 42/18722 0.0643180838236383 0.224233693170336 LRP1/GOLGA4/MACF1/NRP1/RAB11A 5 GO:0051348 negative regulation of transferase activity 20/969 268/18722 0.0646854189941165 0.225363999775502 CAV1/GADD45B/RPL11/RPS20/NR2F2/PLEC/HSPB1/DUSP1/NPM1/GSTP1/LRP5/PPIA/PHPT1/GNAQ/NF1/LATS2/ADAR/BMP7/WNK1/HNRNPU 20 GO:0035150 regulation of tube size 12/969 142/18722 0.0647552740122524 0.22545706994539 EGFR/ATP2B1/CAV1/GJA1/ROCK1/GPX1/ADRB1/RHOA/SOD3/SLC6A4/GJA5/GCLM 12 GO:0061448 connective tissue development 19/969 252/18722 0.0649567337948353 0.226007916652336 GLG1/TRIP11/EGR1/LRP5/ITGB8/GLI3/EFEMP1/SCIN/SMAD5/CREB3L2/NFIB/LTBP3/ESRRA/BMP7/MAPK14/XBP1/ARID5B/CFLAR/SERPINH1 19 GO:0030072 peptide hormone secretion 18/969 236/18722 0.0650590298840245 0.226078061583254 EGFR/LRP1/DYNLL1/GJA1/SOX4/ANXA1/ISL1/LRP5/PHPT1/KIF5B/SYT7/CCDC186/TCF7L2/HMGN3/DPP4/REST/CAMK2G/SRI 18 GO:0046785 microtubule polymerization 8/969 83/18722 0.0650634145850008 0.226078061583254 AKAP9/CLIP1/MET/RPS3/HSPA1A/CAMSAP2/HSPA1B/STMN1 8 GO:0006694 steroid biosynthetic process 14/969 173/18722 0.0653820731032642 0.227034361486816 SF1/PBX1/CYP11A1/EGR1/CYP19A1/PRLR/SLC27A2/DHCR24/AKR1B1/MBTPS1/OSBPL9/REST/ACBD3/CYB5R1 14 GO:1903706 regulation of hemopoiesis 26/969 367/18722 0.0657108936527487 0.22802465486671 FBN1/JUN/FOS/CSF3R/CD46/ZFP36L1/PRKDC/SOX4/ANXA1/CDK6/HSPA1A/GLI3/SCIN/RCOR1/PIK3R1/RHOA/FOXP1/JAG1/MMP14/ESRRA/MAPK14/XBP1/NFKBIA/HSPA1B/GATA3/PRMT1 26 GO:1904029 regulation of cyclin-dependent protein kinase activity 9/969 98/18722 0.0671101390712116 0.231771093166043 EGFR/CCNL1/NR2F2/LATS2/SERTAD1/CKS1B/CDKN3/CCNB1/CCNE1 9 GO:0010800 positive regulation of peptidyl-threonine phosphorylation 4/969 30/18722 0.0671453186095271 0.231771093166043 APP/CALM1/BMP7/CALM2 4 GO:0031571 mitotic G1 DNA damage checkpoint signaling 4/969 30/18722 0.0671453186095271 0.231771093166043 RPL26/PRKDC/SOX4/WAC 4 GO:0048147 negative regulation of fibroblast proliferation 4/969 30/18722 0.0671453186095271 0.231771093166043 FTH1/GSTP1/NF1/PAWR 4 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 4/969 30/18722 0.0671453186095271 0.231771093166043 PHPT1/LGALS3/PAWR/EZR 4 GO:0060218 hematopoietic stem cell differentiation 4/969 30/18722 0.0671453186095271 0.231771093166043 N4BP2L2/PRKDC/UFL1/CHD2 4 GO:0061384 heart trabecula morphogenesis 4/969 30/18722 0.0671453186095271 0.231771093166043 ADAMTS1/TGFBR3/BMP7/RBPJ 4 GO:1903579 negative regulation of ATP metabolic process 4/969 30/18722 0.0671453186095271 0.231771093166043 PARP1/RHOA/NCOR1/DNAJC15 4 GO:0034763 negative regulation of transmembrane transport 12/969 143/18722 0.0675299780140095 0.232944993466147 CAV1/C4orf3/GSTO1/ANK3/OAZ1/CALM1/GOPC/YWHAE/VDAC1/CALM2/YWHAQ/SRI 12 GO:0001659 temperature homeostasis 14/969 174/18722 0.0678909419477148 0.234035661358019 CAV1/DYNC1H1/GJA1/LGR4/EGR1/IGF1R/GPX1/ADRB1/PRLR/EPAS1/ESRRG/RBPJ/DDIT3/ID1 14 GO:0031623 receptor internalization 10/969 113/18722 0.0679869957128424 0.234212287142594 LRP1/CAV1/ITGB1/CD63/CLTC/TFRC/AHI1/LRPAP1/ATXN2/EZR 10 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 6/969 56/18722 0.0684700806523429 0.235256174549076 ZFP36L1/TNRC6B/TNRC6A/AGO2/BTG2/PABPC1 6 GO:0031529 ruffle organization 6/969 56/18722 0.0684700806523429 0.235256174549076 CAV1/PFN1/KANK1/EPS8L1/EPS8/TACSTD2 6 GO:0051058 negative regulation of small GTPase mediated signal transduction 6/969 56/18722 0.0684700806523429 0.235256174549076 ITGB1/MET/KANK1/RASA1/TIMP2/STMN1 6 GO:1904645 response to amyloid-beta 6/969 56/18722 0.0684700806523429 0.235256174549076 LRP1/APP/GJA1/IGF1R/PARP1/CASP4 6 GO:0099111 microtubule-based transport 15/969 190/18722 0.0687312739719232 0.235998447948272 ARMCX3/APP/DYNC1H1/DST/HSPB1/ARHGAP21/KIF5B/PURA/PCM1/RAB6A/FLOT2/CDC42/SFPQ/HNRNPU/UXT 15 GO:0032370 positive regulation of lipid transport 8/969 84/18722 0.068817364686295 0.236138902068665 LRP1/CAV1/ANXA2/CYP19A1/ABCA1/NFKBIA/RXRA/TMF1 8 GO:0007599 hemostasis 17/969 222/18722 0.0693914846427696 0.237796654913517 F5/CAV1/ACTG1/FBLN1/LMAN1/HSPB1/IL6ST/ANXA2/PPIA/GNAQ/TLN1/MYL12A/JMJD1C/GNA12/CLIC1/VCL/MAPK14 17 GO:0050817 coagulation 17/969 222/18722 0.0693914846427696 0.237796654913517 F5/CAV1/ACTG1/FBLN1/LMAN1/HSPB1/IL6ST/ANXA2/PPIA/GNAQ/TLN1/MYL12A/JMJD1C/GNA12/CLIC1/VCL/MAPK14 17 GO:1903037 regulation of leukocyte cell-cell adhesion 24/969 336/18722 0.069453238635446 0.237852310032006 CAV1/CD46/NFAT5/IGF2/DLG5/RPS3/SOX4/ANXA1/IL6ST/DOCK8/DLG1/MIA3/GLI3/TFRC/RHOA/LGALS3/PAWR/WNK1/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 24 GO:0016266 O-glycan processing 5/969 43/18722 0.0698262858114433 0.238193322226242 GALNT11/C1GALT1/B4GALT5/B3GNT2/GALNT1 5 GO:0031952 regulation of protein autophosphorylation 5/969 43/18722 0.0698262858114433 0.238193322226242 CAV1/IQGAP1/RAD50/CALM1/CALM2 5 GO:0033046 negative regulation of sister chromatid segregation 5/969 43/18722 0.0698262858114433 0.238193322226242 DUSP1/TPR/LCMT1/CCNB1/PTTG1 5 GO:0033048 negative regulation of mitotic sister chromatid segregation 5/969 43/18722 0.0698262858114433 0.238193322226242 DUSP1/TPR/LCMT1/CCNB1/PTTG1 5 GO:0120178 steroid hormone biosynthetic process 5/969 43/18722 0.0698262858114433 0.238193322226242 CYP11A1/EGR1/CYP19A1/AKR1B1/REST 5 GO:2000816 negative regulation of mitotic sister chromatid separation 5/969 43/18722 0.0698262858114433 0.238193322226242 DUSP1/TPR/LCMT1/CCNB1/PTTG1 5 GO:0010821 regulation of mitochondrion organization 12/969 144/18722 0.0703810726232749 0.239460602558096 GPX1/VPS13C/PMAIP1/HSPA1A/HUWE1/TFRC/PISD/NMT1/EP300/VDAC1/GHITM/AURKA 12 GO:0033135 regulation of peptidyl-serine phosphorylation 12/969 144/18722 0.0703810726232749 0.239460602558096 EGFR/AKAP9/CAV1/APP/MIF/TFRC/ATP2B4/RICTOR/EIF4G1/NSD1/TXN/DMD 12 GO:0106106 cold-induced thermogenesis 12/969 144/18722 0.0703810726232749 0.239460602558096 CAV1/DYNC1H1/GJA1/LGR4/IGF1R/ADRB1/PRLR/EPAS1/ESRRG/RBPJ/DDIT3/ID1 12 GO:0120161 regulation of cold-induced thermogenesis 12/969 144/18722 0.0703810726232749 0.239460602558096 CAV1/DYNC1H1/GJA1/LGR4/IGF1R/ADRB1/PRLR/EPAS1/ESRRG/RBPJ/DDIT3/ID1 12 GO:0003300 cardiac muscle hypertrophy 9/969 99/18722 0.0706081121528851 0.240076769102783 IL6ST/ROCK1/AKAP13/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1 9 GO:0051924 regulation of calcium ion transport 19/969 255/18722 0.0712027668084174 0.241203912620599 AHNAK/ATP2B1/CAV1/C4orf3/GSTO1/GJA1/DIAPH1/PDE4B/SLC9A1/RHOA/LGALS3/DMD/CALM1/HOMER1/CAMK2G/YWHAE/VDAC1/CALM2/SRI 19 GO:0072593 reactive oxygen species metabolic process 18/969 239/18722 0.0715397601926644 0.241203912620599 EGFR/GPX3/PRDX6/PRDX1/GSTP1/GPX1/PMAIP1/SLC5A3/RHOA/SOD3/TFAP2A/BMP7/MAPK14/CFLAR/STK17A/VDAC1/ARF4/NDUFA13 18 GO:1903039 positive regulation of leukocyte cell-cell adhesion 18/969 239/18722 0.0715397601926644 0.241203912620599 CAV1/CD46/NFAT5/IGF2/RPS3/SOX4/ANXA1/IL6ST/DOCK8/GLI3/TFRC/RHOA/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 18 GO:0043271 negative regulation of ion transport 13/969 160/18722 0.0720160265257798 0.241203912620599 CAV1/C4orf3/GSTO1/ANK3/GABRE/CALM1/WNK1/GOPC/YWHAE/VDAC1/CALM2/YWHAQ/SRI 13 GO:0000028 ribosomal small subunit assembly 3/969 19/18722 0.0721857863257974 0.241203912620599 PRKDC/RPS5/RPSA 3 GO:0007039 protein catabolic process in the vacuole 3/969 19/18722 0.0721857863257974 0.241203912620599 LRP2/LRP1/VPS13A 3 GO:0007530 sex determination 3/969 19/18722 0.0721857863257974 0.241203912620599 SF1/MAP3K4/CITED2 3 GO:0010002 cardioblast differentiation 3/969 19/18722 0.0721857863257974 0.241203912620599 ISL1/RBPJ/REST 3 GO:0030011 maintenance of cell polarity 3/969 19/18722 0.0721857863257974 0.241203912620599 DLG5/DST/SLC9A1 3 GO:0031290 retinal ganglion cell axon guidance 3/969 19/18722 0.0721857863257974 0.241203912620599 RPL24/ISL1/NRP1 3 GO:0035461 vitamin transmembrane transport 3/969 19/18722 0.0721857863257974 0.241203912620599 LRP2/SLC19A3/SLC19A1 3 GO:0035728 response to hepatocyte growth factor 3/969 19/18722 0.0721857863257974 0.241203912620599 NRP1/GAB1/GCLM 3 GO:0036498 IRE1-mediated unfolded protein response 3/969 19/18722 0.0721857863257974 0.241203912620599 HSPA5/UFL1/XBP1 3 GO:0044003 modulation by symbiont of host process 3/969 19/18722 0.0721857863257974 0.241203912620599 DAG1/SERPINB9/RXRA 3 GO:0045019 negative regulation of nitric oxide biosynthetic process 3/969 19/18722 0.0721857863257974 0.241203912620599 CAV1/DYNLL1/ATP2B4 3 GO:0045780 positive regulation of bone resorption 3/969 19/18722 0.0721857863257974 0.241203912620599 EGFR/TFRC/LTBP3 3 GO:0046716 muscle cell cellular homeostasis 3/969 19/18722 0.0721857863257974 0.241203912620599 ALDOA/GAA/DMD 3 GO:0060216 definitive hemopoiesis 3/969 19/18722 0.0721857863257974 0.241203912620599 TGFBR3/ADAR/MFAP5 3 GO:0070262 peptidyl-serine dephosphorylation 3/969 19/18722 0.0721857863257974 0.241203912620599 PPP1R15A/DUSP1/YWHAE 3 GO:0070734 histone H3-K27 methylation 3/969 19/18722 0.0721857863257974 0.241203912620599 MTF2/SUPT6H/GATA3 3 GO:0090670 RNA localization to Cajal body 3/969 19/18722 0.0721857863257974 0.241203912620599 NHP2/CCT8/NOP10 3 GO:0090671 telomerase RNA localization to Cajal body 3/969 19/18722 0.0721857863257974 0.241203912620599 NHP2/CCT8/NOP10 3 GO:0090672 telomerase RNA localization 3/969 19/18722 0.0721857863257974 0.241203912620599 NHP2/CCT8/NOP10 3 GO:0090685 RNA localization to nucleus 3/969 19/18722 0.0721857863257974 0.241203912620599 NHP2/CCT8/NOP10 3 GO:1900221 regulation of amyloid-beta clearance 3/969 19/18722 0.0721857863257974 0.241203912620599 LRP1/ROCK1/LRPAP1 3 GO:1904406 negative regulation of nitric oxide metabolic process 3/969 19/18722 0.0721857863257974 0.241203912620599 CAV1/DYNLL1/ATP2B4 3 GO:2000269 regulation of fibroblast apoptotic process 3/969 19/18722 0.0721857863257974 0.241203912620599 BTG1/CHD8/STK17A 3 GO:0030433 ubiquitin-dependent ERAD pathway 8/969 85/18722 0.0727014280918833 0.242771669781586 CAV1/HSP90B1/HSPA5/SEL1L/DNAJB14/CCDC47/FAF2/UBXN4 8 GO:0033619 membrane protein proteolysis 6/969 57/18722 0.0733439152509395 0.244137134459497 DAG1/ROCK1/MBTPS1/SPPL3/AFG3L2/TIMP2 6 GO:0051205 protein insertion into membrane 6/969 57/18722 0.0733439152509395 0.244137134459497 EGFR/EMC1/CCDC47/NMT1/EMC10/NDUFA13 6 GO:0051785 positive regulation of nuclear division 6/969 57/18722 0.0733439152509395 0.244137134459497 IGF2/LRP5/PHIP/ANAPC11/NUSAP1/AURKA 6 GO:0060042 retina morphogenesis in camera-type eye 6/969 57/18722 0.0733439152509395 0.244137134459497 LRP5/AHI1/MAN2A1/TFAP2A/NAGLU/OBSL1 6 GO:0097120 receptor localization to synapse 6/969 57/18722 0.0733439152509395 0.244137134459497 DAG1/DLG1/KIF5B/RAB11A/CLSTN1/VAMP2 6 GO:0007190 activation of adenylate cyclase activity 4/969 31/18722 0.0740755584030325 0.245945913732051 LGR5/LGR4/ADRB1/CALM1 4 GO:0044819 mitotic G1/S transition checkpoint signaling 4/969 31/18722 0.0740755584030325 0.245945913732051 RPL26/PRKDC/SOX4/WAC 4 GO:0090183 regulation of kidney development 4/969 31/18722 0.0740755584030325 0.245945913732051 LGR4/MAGED1/TACSTD2/GATA3 4 GO:2000144 positive regulation of DNA-templated transcription, initiation 4/969 31/18722 0.0740755584030325 0.245945913732051 JUN/BCLAF1/SETX/MED13 4 GO:0044728 DNA methylation or demethylation 9/969 100/18722 0.0742174296845079 0.245980779490778 FOS/ATRX/TET2/PARP1/USP9X/MPHOSPH8/DNMT3A/BAZ2A/GATA3 9 GO:0046545 development of primary female sexual characteristics 9/969 100/18722 0.0742174296845079 0.245980779490778 HSPA5/ADAMTS1/NR2F2/CYP19A1/NRIP1/MMP14/ZFX/ARID5B/IDH1 9 GO:0043467 regulation of generation of precursor metabolites and energy 11/969 130/18722 0.0742272654529196 0.245980779490778 APP/IGF2/RHOA/NCOR1/SORBS1/EP300/CDK1/PGAM1/DNAJC15/GHITM/CCNB1 11 GO:0030278 regulation of ossification 10/969 115/18722 0.0746086671380721 0.247088019305174 FBN2/ATP2B1/PBX1/NIPBL/TFAP2A/LTBP3/ESRRA/BMP7/MAPK14/RBPJ 10 GO:0005978 glycogen biosynthetic process 5/969 44/18722 0.0755860040789071 0.249376551336091 IGF2/AGL/PTGES3/SORBS1/UGP2 5 GO:0006378 mRNA polyadenylation 5/969 44/18722 0.0755860040789071 0.249376551336091 APP/PCF11/AHCYL1/YTHDC1/PABPC1 5 GO:0009250 glucan biosynthetic process 5/969 44/18722 0.0755860040789071 0.249376551336091 IGF2/AGL/PTGES3/SORBS1/UGP2 5 GO:0048806 genitalia development 5/969 44/18722 0.0755860040789071 0.249376551336091 LRP2/LGR4/NIPBL/DHCR24/TBX3 5 GO:0050999 regulation of nitric-oxide synthase activity 5/969 44/18722 0.0755860040789071 0.249376551336091 EGFR/CAV1/ATP2B4/CALM1/KRAS 5 GO:1903573 negative regulation of response to endoplasmic reticulum stress 5/969 44/18722 0.0755860040789071 0.249376551336091 HSPA5/PPP1R15A/UFL1/HSPA1A/XBP1 5 GO:0006476 protein deacetylation 9/969 101/18722 0.0779383538744284 0.256908032698408 NIPBL/KDM5A/MORF4L2/TBL1X/RCOR1/EP300/BAZ2A/REST/SFPQ 9 GO:0007006 mitochondrial membrane organization 10/969 116/18722 0.0780654335868872 0.256908032698408 PMAIP1/HSPA1A/SLC9A1/CALM1/NMT1/AFG3L2/DYNLT1/GHITM/NDUFA13/VDAC2 10 GO:0018107 peptidyl-threonine phosphorylation 10/969 116/18722 0.0780654335868872 0.256908032698408 APP/PRKDC/ROCK1/CSNK2B/EIF4G1/CALM1/BMP7/WNK1/CDK1/CALM2 10 GO:0031123 RNA 3'-end processing 10/969 116/18722 0.0780654335868872 0.256908032698408 RPS21/APP/ZFP36L1/PCF11/INTS6/AHCYL1/YTHDC1/PABPC1/CCNB1/SSB 10 GO:0042246 tissue regeneration 7/969 72/18722 0.0783472073184313 0.257673068248032 DAG1/ANXA1/GPX1/PTPN12/CFLAR/KLF5/CCNB1 7 GO:0061025 membrane fusion 13/969 163/18722 0.0806598258057859 0.263347664883736 ANXA1/ANXA2/EEA1/HUWE1/KIF5B/CTSL/SYT7/SPESP1/MYOF/UVRAG/VAMP2/CAV2/VAMP3 13 GO:1903131 mononuclear cell differentiation 29/969 426/18722 0.0807629863452199 0.263347664883736 JUN/CD46/RPS6/ZFP36L1/ITGB1/PBX1/PRKDC/RPL22/SOX4/ANXA1/CDK6/DHRS2/EGR1/HECTD1/ITGB8/CTSL/GLI3/PIK3R1/RHOA/FOXP1/MMP14/YY1/EP300/XBP1/ITFG2/RBPJ/IRF2BP2/GATA3/TPD52 29 GO:0019646 aerobic electron transport chain 8/969 87/18722 0.0808605437670408 0.263347664883736 COX6A1/UQCRH/COX8C/COX5A/UQCRQ/DNAJC15/NDUFA6/SDHC 8 GO:2000177 regulation of neural precursor cell proliferation 8/969 87/18722 0.0808605437670408 0.263347664883736 LRP2/ADGRG1/SPINT1/GLI3/NF1/RHOA/SLC6A4/BTG2 8 GO:0021799 cerebral cortex radially oriented cell migration 4/969 32/18722 0.0813521857102354 0.263347664883736 LAMB1/ADGRG1/GLI3/RTN4 4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 4/969 32/18722 0.0813521857102354 0.263347664883736 TGFBR3/FERMT1/EP300/CITED2 4 GO:0035767 endothelial cell chemotaxis 4/969 32/18722 0.0813521857102354 0.263347664883736 MET/HSPB1/NRP1/TMSB4X 4 GO:0042744 hydrogen peroxide catabolic process 4/969 32/18722 0.0813521857102354 0.263347664883736 GPX3/PRDX6/PRDX1/GPX1 4 GO:0060914 heart formation 4/969 32/18722 0.0813521857102354 0.263347664883736 LRP2/ISL1/RBPJ/HES1 4 GO:0071875 adrenergic receptor signaling pathway 4/969 32/18722 0.0813521857102354 0.263347664883736 AKAP13/ADRB1/ATP2B4/PDE4B 4 GO:1900745 positive regulation of p38MAPK cascade 4/969 32/18722 0.0813521857102354 0.263347664883736 GADD45B/MAP3K4/EMC10/PRMT1 4 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 4/969 32/18722 0.0813521857102354 0.263347664883736 PMAIP1/HSPA1A/XBP1/DDIT3 4 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 4/969 32/18722 0.0813521857102354 0.263347664883736 TGFBR3/FERMT1/EP300/CITED2 4 GO:1905476 negative regulation of protein localization to membrane 4/969 32/18722 0.0813521857102354 0.263347664883736 CLTC/HECTD1/PPFIA1/GOPC 4 GO:0035305 negative regulation of dephosphorylation 5/969 45/18722 0.0815946995671201 0.263347664883736 BOD1L1/PPP1R15A/ROCK1/LGALS3/YWHAE 5 GO:0043631 RNA polyadenylation 5/969 45/18722 0.0815946995671201 0.263347664883736 APP/PCF11/AHCYL1/YTHDC1/PABPC1 5 GO:0051180 vitamin transport 5/969 45/18722 0.0815946995671201 0.263347664883736 LRP2/SLC2A1/SLC19A3/SLC52A3/SLC19A1 5 GO:0051985 negative regulation of chromosome segregation 5/969 45/18722 0.0815946995671201 0.263347664883736 DUSP1/TPR/LCMT1/CCNB1/PTTG1 5 GO:1905819 negative regulation of chromosome separation 5/969 45/18722 0.0815946995671201 0.263347664883736 DUSP1/TPR/LCMT1/CCNB1/PTTG1 5 GO:0030100 regulation of endocytosis 16/969 211/18722 0.0816563204851352 0.263347664883736 LRP1/CAV1/ITGAV/AAK1/CD63/ROCK1/ANXA2/ZFYVE16/AHI1/STON1/LRPAP1/LGALS3/CALM1/ATXN2/CDC42/RAB17 16 GO:0014897 striated muscle hypertrophy 9/969 102/18722 0.0817710248465226 0.263347664883736 IL6ST/ROCK1/AKAP13/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1 9 GO:1904063 negative regulation of cation transmembrane transport 9/969 102/18722 0.0817710248465226 0.263347664883736 CAV1/C4orf3/GSTO1/ANK3/CALM1/YWHAE/VDAC1/CALM2/SRI 9 GO:0006851 mitochondrial calcium ion transmembrane transport 3/969 20/18722 0.0817859280723886 0.263347664883736 AFG3L2/VDAC1/STOML2 3 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 3/969 20/18722 0.0817859280723886 0.263347664883736 EIF4G1/CALM1/CALM2 3 GO:0032211 negative regulation of telomere maintenance via telomerase 3/969 20/18722 0.0817859280723886 0.263347664883736 HNRNPA1/HNRNPC/HNRNPU 3 GO:0032495 response to muramyl dipeptide 3/969 20/18722 0.0817859280723886 0.263347664883736 JAG1/MAPK14/NFKBIA 3 GO:0039535 regulation of RIG-I signaling pathway 3/969 20/18722 0.0817859280723886 0.263347664883736 PUM1/ANKRD17/PUM2 3 GO:0043011 myeloid dendritic cell differentiation 3/969 20/18722 0.0817859280723886 0.263347664883736 DHRS2/ITGB8/RBPJ 3 GO:0061318 renal filtration cell differentiation 3/969 20/18722 0.0817859280723886 0.263347664883736 IQGAP1/JAG1/CD24 3 GO:0071731 response to nitric oxide 3/969 20/18722 0.0817859280723886 0.263347664883736 MTR/TXN/CFLAR 3 GO:0072112 glomerular visceral epithelial cell differentiation 3/969 20/18722 0.0817859280723886 0.263347664883736 IQGAP1/JAG1/CD24 3 GO:1901679 nucleotide transmembrane transport 3/969 20/18722 0.0817859280723886 0.263347664883736 SLC25A36/SLC25A6/SLC19A1 3 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/969 20/18722 0.0817859280723886 0.263347664883736 HSPB1/PPIA/GPX1 3 GO:2000678 negative regulation of transcription regulatory region DNA binding 3/969 20/18722 0.0817859280723886 0.263347664883736 TMSB4X/DDIT3/SRI 3 GO:0006260 DNA replication 19/969 260/18722 0.0824912741266329 0.26545529469568 JUN/EGFR/S100A11/BOD1L1/ATRX/PURA/PDS5A/RBBP6/ANKRD17/RBMS1/ZBTB38/NFIB/HMGA1/CDC42/CDK1/CACYBP/PTMS/STOML2/CCNE1 19 GO:0014074 response to purine-containing compound 12/969 148/18722 0.0825565356677907 0.265501818707615 JUN/AKAP9/FOS/LDHA/HSP90B1/FOSB/APP/HSPA5/ZFP36L1/DUSP1/SLC6A4/EZR 12 GO:0006767 water-soluble vitamin metabolic process 6/969 59/18722 0.0836694905568573 0.268750312016064 GSTO1/SLC2A1/MTR/SLC19A3/SLC52A3/SLC19A1 6 GO:2001258 negative regulation of cation channel activity 6/969 59/18722 0.0836694905568573 0.268750312016064 CAV1/GSTO1/ANK3/CALM1/CALM2/SRI 6 GO:0007033 vacuole organization 14/969 180/18722 0.0842777981885494 0.27053794430796 GRN/GAA/ANXA2/HOOK2/RB1CC1/SYT7/ABCA1/MAN2A1/GNPTAB/MBTPS1/RAB3GAP2/NAGLU/HOOK3/ATP6AP2 14 GO:0006006 glucose metabolic process 15/969 196/18722 0.0844581986244314 0.270784384055999 GAPDH/TPI1/IGF2/ENO1/DDB1/GAA/LRP5/RANBP2/PMAIP1/SORBS1/MAPK14/EP300/SLC35B4/LCMT1/PGK1 15 GO:0090276 regulation of peptide hormone secretion 15/969 196/18722 0.0844581986244314 0.270784384055999 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/LRP5/PHPT1/KIF5B/SYT7/TCF7L2/HMGN3/DPP4/REST/SRI 15 GO:0001843 neural tube closure 8/969 88/18722 0.0851354975265588 0.272621390976591 LRP2/PFN1/SPINT1/LMO4/BRD2/HECTD1/SETD2/CITED2 8 GO:0009144 purine nucleoside triphosphate metabolic process 8/969 88/18722 0.0851354975265588 0.272621390976591 ALDOA/ENO1/TMSB4X/PARP1/RAN/RHOA/STOML2/IMPDH2 8 GO:0014013 regulation of gliogenesis 9/969 103/18722 0.0857154605227871 0.274142592834814 EGFR/LRP2/DAG1/SPINT1/IL6ST/UFL1/NF1/DICER1/HES1 9 GO:0050773 regulation of dendrite development 9/969 103/18722 0.0857154605227871 0.274142592834814 IQGAP1/CUX1/RHOA/CAMSAP2/BMP7/OBSL1/ID1/RAB17/CDC20 9 GO:0023061 signal release 31/969 463/18722 0.0861216907678373 0.275273367555179 EGFR/LRP1/DYNLL1/WLS/GJA1/SOX4/ANXA1/ISL1/LRP5/CYP19A1/PHPT1/PPP1R9A/KIF5B/TBX3/KDM5B/SYT7/MCTP2/ABCA1/CCDC186/TCF7L2/TRPV6/CALM1/SLC6A4/HMGN3/DPP4/TMF1/REST/VAMP2/CAMK2G/GATA3/SRI 31 GO:0048332 mesoderm morphogenesis 7/969 74/18722 0.0877999730965502 0.279768441017283 ITGB4/ITGB1/WLS/GJA1/SETD2/TBX3/BMP7 7 GO:0006984 ER-nucleus signaling pathway 5/969 46/18722 0.0878492177017532 0.279768441017283 HSPA5/PPP1R15A/CCDC47/MBTPS1/DDIT3 5 GO:0048701 embryonic cranial skeleton morphogenesis 5/969 46/18722 0.0878492177017532 0.279768441017283 NIPBL/SETD2/GLI3/TFAP2A/MMP14 5 GO:0060976 coronary vasculature development 5/969 46/18722 0.0878492177017532 0.279768441017283 LRP2/ADAMTS6/TGFBR3/NRP1/SETD2 5 GO:0070828 heterochromatin organization 5/969 46/18722 0.0878492177017532 0.279768441017283 TPR/HP1BP3/MPHOSPH8/DNMT3A/BAZ2A 5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 5/969 46/18722 0.0878492177017532 0.279768441017283 EGFR/ADAMTS1/ANXA1/EIF4G1/ANKRD17 5 GO:0006891 intra-Golgi vesicle-mediated transport 4/969 33/18722 0.0889669954160445 0.280372877276703 CUX1/COPA/RAB6A/COPB1 4 GO:0010165 response to X-ray 4/969 33/18722 0.0889669954160445 0.280372877276703 ANXA1/NIPBL/XRRA1/GATA3 4 GO:0046685 response to arsenic-containing substance 4/969 33/18722 0.0889669954160445 0.280372877276703 GSTO1/SLC38A2/HNRNPA1/HMOX1 4 GO:1902275 regulation of chromatin organization 4/969 33/18722 0.0889669954160445 0.280372877276703 TPR/MPHOSPH8/SETD5/HNRNPU 4 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 6/969 60/18722 0.0891186799573619 0.280372877276703 PUM1/HSPA1A/ANKRD17/PUM2/NFKBIA/HSPA1B 6 GO:0031638 zymogen activation 6/969 60/18722 0.0891186799573619 0.280372877276703 ENO1/DHCR24/CTSL/ASPH/MMP14/PGK1 6 GO:0051851 modulation by host of symbiont process 6/969 60/18722 0.0891186799573619 0.280372877276703 JUN/CFL1/EP300/EIF2AK4/REST/CAV2 6 GO:0055008 cardiac muscle tissue morphogenesis 6/969 60/18722 0.0891186799573619 0.280372877276703 LRP2/DSP/TGFBR3/ISL1/LY6E/RBPJ 6 GO:0016197 endosomal transport 17/969 230/18722 0.0891417855476097 0.280372877276703 EEA1/CLTC/GCC2/ERC1/KIAA1109/ZFYVE16/RAB11A/TMEM87A/ABCA1/RAB6A/RHOBTB3/EVI5/SNX18/SPAG9/RAB17/VAMP3/VPS29 17 GO:0045333 cellular respiration 17/969 230/18722 0.0891417855476097 0.280372877276703 PLEC/COX6A1/UQCRH/COX8C/RHOA/COX5A/IDH1/UQCRQ/COX7B/CDK1/DNAJC15/GHITM/MDH2/STOML2/NDUFA6/CCNB1/SDHC 17 GO:0009199 ribonucleoside triphosphate metabolic process 8/969 89/18722 0.0895403692039069 0.280372877276703 ALDOA/ENO1/TMSB4X/PARP1/RAN/RHOA/STOML2/IMPDH2 8 GO:0060606 tube closure 8/969 89/18722 0.0895403692039069 0.280372877276703 LRP2/PFN1/SPINT1/LMO4/BRD2/HECTD1/SETD2/CITED2 8 GO:0014896 muscle hypertrophy 9/969 104/18722 0.0897715567739493 0.280372877276703 IL6ST/ROCK1/AKAP13/PARP1/ATP2B4/SLC9A1/JARID2/DDX39B/YY1 9 GO:0045621 positive regulation of lymphocyte differentiation 9/969 104/18722 0.0897715567739493 0.280372877276703 CD46/PRKDC/SOX4/ANXA1/GLI3/RHOA/MMP14/XBP1/GATA3 9 GO:0048661 positive regulation of smooth muscle cell proliferation 9/969 104/18722 0.0897715567739493 0.280372877276703 JUN/EGFR/ADAMTS1/GJA1/FOXP1/AKR1B1/DDX39B/HMOX1/HPGD 9 GO:0000492 box C/D snoRNP assembly 2/969 10/18722 0.0913937272282626 0.280372877276703 SNU13/TAF9 2 GO:0002934 desmosome organization 2/969 10/18722 0.0913937272282626 0.280372877276703 DSP/DSG2 2 GO:0003056 regulation of vascular associated smooth muscle contraction 2/969 10/18722 0.0913937272282626 0.280372877276703 ATP2B1/RHOA 2 GO:0003163 sinoatrial node development 2/969 10/18722 0.0913937272282626 0.280372877276703 ISL1/TBX3 2 GO:0007028 cytoplasm organization 2/969 10/18722 0.0913937272282626 0.280372877276703 KIF5B/TFCP2L1 2 GO:0009750 response to fructose 2/969 10/18722 0.0913937272282626 0.280372877276703 KRT18/XBP1 2 GO:0010968 regulation of microtubule nucleation 2/969 10/18722 0.0913937272282626 0.280372877276703 HSPA1A/HSPA1B 2 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 2/969 10/18722 0.0913937272282626 0.280372877276703 NPM1/EIF2AK4 2 GO:0017085 response to insecticide 2/969 10/18722 0.0913937272282626 0.280372877276703 UBA52/CCNB1 2 GO:0021562 vestibulocochlear nerve development 2/969 10/18722 0.0913937272282626 0.280372877276703 NRP2/NRP1 2 GO:0021903 rostrocaudal neural tube patterning 2/969 10/18722 0.0913937272282626 0.280372877276703 ATP6AP2/HES1 2 GO:0021932 hindbrain radial glia guided cell migration 2/969 10/18722 0.0913937272282626 0.280372877276703 ITGB1/RERE 2 GO:0031118 rRNA pseudouridine synthesis 2/969 10/18722 0.0913937272282626 0.280372877276703 NHP2/NOP10 2 GO:0032070 regulation of deoxyribonuclease activity 2/969 10/18722 0.0913937272282626 0.280372877276703 RPS3/NPM1 2 GO:0032275 luteinizing hormone secretion 2/969 10/18722 0.0913937272282626 0.280372877276703 TBX3/TMF1 2 GO:0033572 transferrin transport 2/969 10/18722 0.0913937272282626 0.280372877276703 CLTC/TFRC 2 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence 2/969 10/18722 0.0913937272282626 0.280372877276703 EMC1/EMC10 2 GO:0048755 branching morphogenesis of a nerve 2/969 10/18722 0.0913937272282626 0.280372877276703 RERE/RTN4 2 GO:0050861 positive regulation of B cell receptor signaling pathway 2/969 10/18722 0.0913937272282626 0.280372877276703 SLC39A10/FOXP1 2 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 2/969 10/18722 0.0913937272282626 0.280372877276703 CALM1/CALM2 2 GO:0051351 positive regulation of ligase activity 2/969 10/18722 0.0913937272282626 0.280372877276703 TMSB4X/GCLM 2 GO:0051660 establishment of centrosome localization 2/969 10/18722 0.0913937272282626 0.280372877276703 DLG1/EZR 2 GO:0060923 cardiac muscle cell fate commitment 2/969 10/18722 0.0913937272282626 0.280372877276703 TBX3/RBPJ 2 GO:0061299 retina vasculature morphogenesis in camera-type eye 2/969 10/18722 0.0913937272282626 0.280372877276703 LRP5/NRP1 2 GO:0072070 loop of Henle development 2/969 10/18722 0.0913937272282626 0.280372877276703 IRX2/JAG1 2 GO:0072178 nephric duct morphogenesis 2/969 10/18722 0.0913937272282626 0.280372877276703 AHI1/GATA3 2 GO:0072203 cell proliferation involved in metanephros development 2/969 10/18722 0.0913937272282626 0.280372877276703 EGR1/BMP7 2 GO:0090647 modulation of age-related behavioral decline 2/969 10/18722 0.0913937272282626 0.280372877276703 APP/BAZ2B 2 GO:0140059 dendrite arborization 2/969 10/18722 0.0913937272282626 0.280372877276703 NRP1/TPBG 2 GO:1901524 regulation of mitophagy 2/969 10/18722 0.0913937272282626 0.280372877276703 VPS13C/VDAC1 2 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/969 10/18722 0.0913937272282626 0.280372877276703 PMAIP1/DDIT3 2 GO:1902946 protein localization to early endosome 2/969 10/18722 0.0913937272282626 0.280372877276703 NRP1/EZR 2 GO:1904350 regulation of protein catabolic process in the vacuole 2/969 10/18722 0.0913937272282626 0.280372877276703 LRP2/LRP1 2 GO:1905383 protein localization to presynapse 2/969 10/18722 0.0913937272282626 0.280372877276703 HSPB1/KIF5B 2 GO:2000288 positive regulation of myoblast proliferation 2/969 10/18722 0.0913937272282626 0.280372877276703 MALAT1/PAXBP1 2 GO:2000434 regulation of protein neddylation 2/969 10/18722 0.0913937272282626 0.280372877276703 RPL11/EPAS1 2 GO:2000674 regulation of type B pancreatic cell apoptotic process 2/969 10/18722 0.0913937272282626 0.280372877276703 TCF7L2/SRSF6 2 GO:0002689 negative regulation of leukocyte chemotaxis 3/969 21/18722 0.0919017869833511 0.280372877276703 MIF/DUSP1/DPP4 3 GO:0003177 pulmonary valve development 3/969 21/18722 0.0919017869833511 0.280372877276703 JAG1/GJA5/RBPJ 3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 3/969 21/18722 0.0919017869833511 0.280372877276703 COX6A1/COX8C/COX5A 3 GO:0006353 DNA-templated transcription, termination 3/969 21/18722 0.0919017869833511 0.280372877276703 PCF11/POLR2A/SETX 3 GO:0007350 blastoderm segmentation 3/969 21/18722 0.0919017869833511 0.280372877276703 NRP2/NRP1/TBX3 3 GO:0008090 retrograde axonal transport 3/969 21/18722 0.0919017869833511 0.280372877276703 DYNC1H1/DST/KIF5B 3 GO:0031145 anaphase-promoting complex-dependent catabolic process 3/969 21/18722 0.0919017869833511 0.280372877276703 ANAPC11/UBE2C/CDC20 3 GO:0032288 myelin assembly 3/969 21/18722 0.0919017869833511 0.280372877276703 ITGB4/DICER1/GPC1 3 GO:0033962 P-body assembly 3/969 21/18722 0.0919017869833511 0.280372877276703 DYNC1H1/ATXN2/LSM3 3 GO:0035330 regulation of hippo signaling 3/969 21/18722 0.0919017869833511 0.280372877276703 DLG5/MAPK14/VGLL4 3 GO:0035455 response to interferon-alpha 3/969 21/18722 0.0919017869833511 0.280372877276703 TPR/ADAR/GATA3 3 GO:0046823 negative regulation of nucleocytoplasmic transport 3/969 21/18722 0.0919017869833511 0.280372877276703 TPR/FERMT1/TXN 3 GO:0046885 regulation of hormone biosynthetic process 3/969 21/18722 0.0919017869833511 0.280372877276703 EGR1/REST/STC2 3 GO:0072311 glomerular epithelial cell differentiation 3/969 21/18722 0.0919017869833511 0.280372877276703 IQGAP1/JAG1/CD24 3 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 3/969 21/18722 0.0919017869833511 0.280372877276703 LGR4/MAGED1/TACSTD2 3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/969 21/18722 0.0919017869833511 0.280372877276703 MIF/PTTG1IP/TAF9 3 GO:1902644 tertiary alcohol metabolic process 3/969 21/18722 0.0919017869833511 0.280372877276703 CYP11A1/AKR1B1/REST 3 GO:2000291 regulation of myoblast proliferation 3/969 21/18722 0.0919017869833511 0.280372877276703 MALAT1/ZNF609/PAXBP1 3 GO:2000774 positive regulation of cellular senescence 3/969 21/18722 0.0919017869833511 0.280372877276703 PAWR/HMGA1/KRAS 3 GO:2001014 regulation of skeletal muscle cell differentiation 3/969 21/18722 0.0919017869833511 0.280372877276703 DDX5/DDX17/GPC1 3 GO:0031669 cellular response to nutrient levels 16/969 215/18722 0.0925995567022003 0.282336804740781 JUN/ATP2B1/HSPA5/SLC2A1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/EIF4G1/CTSV/EIF2AK4/XBP1/ITFG2/TRIM24/HMOX1/DNAJC15 16 GO:0036465 synaptic vesicle recycling 7/969 75/18722 0.0927580583991224 0.28265516804304 ACTG1/ROCK1/KIAA1109/SYT7/STON1/CALM1/VAMP2 7 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 5/969 47/18722 0.0943458178190779 0.285992600883121 ENPEP/ADRB1/RHOA/MME/ATP6AP2 5 GO:0010799 regulation of peptidyl-threonine phosphorylation 5/969 47/18722 0.0943458178190779 0.285992600883121 APP/EIF4G1/CALM1/BMP7/CALM2 5 GO:0035315 hair cell differentiation 5/969 47/18722 0.0943458178190779 0.285992600883121 MCOLN3/TRIOBP/JAG1/RBPJ/HES1 5 GO:0042311 vasodilation 5/969 47/18722 0.0943458178190779 0.285992600883121 EGFR/GJA1/GPX1/ADRB1/GJA5 5 GO:0045601 regulation of endothelial cell differentiation 5/969 47/18722 0.0943458178190779 0.285992600883121 ROCK1/BTG1/JAG1/VCL/ID1 5 GO:0045747 positive regulation of Notch signaling pathway 5/969 47/18722 0.0943458178190779 0.285992600883121 AAK1/IL6ST/JAG1/EPN2/HES1 5 GO:0048512 circadian behavior 5/969 47/18722 0.0943458178190779 0.285992600883121 ZFHX3/EGR1/ADRB1/NCOR1/NAGLU 5 GO:0051489 regulation of filopodium assembly 5/969 47/18722 0.0943458178190779 0.285992600883121 NRP1/PPP1R9A/PIK3R1/CDC42/RAB17 5 GO:0072583 clathrin-dependent endocytosis 5/969 47/18722 0.0943458178190779 0.285992600883121 AAK1/CLTC/CLTA/AP2A2/CLTB 5 GO:0006900 vesicle budding from membrane 6/969 61/18722 0.0947564973909134 0.286904667071213 S100A10/ANXA2/MIA3/SEC31A/PDCD6/SEC13 6 GO:1904356 regulation of telomere maintenance via telomere lengthening 6/969 61/18722 0.0947564973909134 0.286904667071213 PARP1/MAP3K4/HNRNPA1/HNRNPC/HNRNPU/CCT8 6 GO:0042391 regulation of membrane potential 29/969 434/18722 0.0960827431559957 0.290623938832584 JUN/AKAP9/CAV1/APP/DSP/GJA1/SLC25A36/ANK3/DLG1/GABRE/DSG2/ADRB1/PARP1/PPP1R9A/PMAIP1/KIF5B/GNAQ/KCNN4/DSC2/SLC9A1/CLIC1/DMD/CALM1/USP53/GJA5/GCLM/YWHAE/SRI/STOML2 29 GO:0002791 regulation of peptide secretion 15/969 200/18722 0.0961279380893774 0.290623938832584 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/LRP5/PHPT1/KIF5B/SYT7/TCF7L2/HMGN3/DPP4/REST/SRI 15 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 18/969 249/18722 0.0962117586309229 0.290623938832584 GAPDH/WLS/GJA1/BRD4/ASH1L/HSPB1/AKAP13/GSTP1/UFL1/TFRC/RHOA/ANKRD17/USP10/NEK6/CFLAR/EEF1D/HMOX1/RHOC 18 GO:0045926 negative regulation of growth 18/969 249/18722 0.0962117586309229 0.290623938832584 SEMA6A/SEMA6D/GJA1/ENO1/NRP1/ADRB1/BTG1/HSPA1A/SMARCA2/JARID2/YY1/SLC6A4/VGLL4/CITED2/RTN4/SPAG9/HSPA1B/NDUFA13 18 GO:0016311 dephosphorylation 28/969 417/18722 0.0962629234824346 0.290623938832584 HSP90B1/SLC39A10/BOD1L1/PPP1R15A/DUSP6/PLPP3/DUSP1/DLG1/ROCK1/PTPN14/PPIA/PHPT1/PTPRF/CTDSPL/PTPRA/CSNK2B/PPP1R12A/PPP6R2/PTPN12/LGALS3/CALM1/PTPRE/TNS3/SPPL3/CAMK2G/YWHAE/CALM2/CDKN3 28 GO:0042177 negative regulation of protein catabolic process 10/969 121/18722 0.0968142637680924 0.29089932930827 EGFR/MYCBP2/RPL11/ROCK1/ANXA2/EIF3H/WAC/MDM4/TIMP2/TAF9 10 GO:1904019 epithelial cell apoptotic process 10/969 121/18722 0.0968142637680924 0.29089932930827 KRT8/KRT18/ZFP36L1/TIA1/TCF7L2/DNMT3A/CFLAR/SRSF6/GATA3/HMOX1 10 GO:0001662 behavioral fear response 4/969 34/18722 0.0969107792433405 0.29089932930827 GJA1/EIF4G1/DPP4/VDAC1 4 GO:0007095 mitotic G2 DNA damage checkpoint signaling 4/969 34/18722 0.0969107792433405 0.29089932930827 TAOK3/FOXN3/TAOK1/CDK1 4 GO:0044319 wound healing, spreading of cells 4/969 34/18722 0.0969107792433405 0.29089932930827 FERMT1/RHOA/RREB1/RHOC 4 GO:0048536 spleen development 4/969 34/18722 0.0969107792433405 0.29089932930827 PBX1/PRKDC/JARID2/CITED2 4 GO:0048741 skeletal muscle fiber development 4/969 34/18722 0.0969107792433405 0.29089932930827 PLEC/GPX1/HOMER1/CAV2 4 GO:0070884 regulation of calcineurin-NFAT signaling cascade 4/969 34/18722 0.0969107792433405 0.29089932930827 NFAT5/ATP2B4/SLC9A1/SPPL3 4 GO:0090505 epiboly involved in wound healing 4/969 34/18722 0.0969107792433405 0.29089932930827 FERMT1/RHOA/RREB1/RHOC 4 GO:1990000 amyloid fibril formation 4/969 34/18722 0.0969107792433405 0.29089932930827 APP/USP9X/SIAH1/SIAH2 4 GO:0021536 diencephalon development 7/969 76/18722 0.0978692511644812 0.293439303835673 NRP2/CDH1/ISL1/NRP1/RBPJ/UQCRQ/HES1 7 GO:0045685 regulation of glial cell differentiation 7/969 76/18722 0.0978692511644812 0.293439303835673 DAG1/SPINT1/IL6ST/NF1/DICER1/CDK1/HES1 7 GO:0001824 blastocyst development 9/969 106/18722 0.0982177069569832 0.293978085084304 RPL13/N4BP2L2/JUNB/RTF1/SUPT6H/ELF3/CITED2/RTN4/UBE2A 9 GO:0006906 vesicle fusion 9/969 106/18722 0.0982177069569832 0.293978085084304 ANXA1/ANXA2/EEA1/KIF5B/SYT7/UVRAG/VAMP2/CAV2/VAMP3 9 GO:2000278 regulation of DNA biosynthetic process 9/969 106/18722 0.0982177069569832 0.293978085084304 GJA1/DUSP1/MAP3K4/PTGES3/HNRNPA1/DDX39B/HNRNPC/HNRNPU/CCT8 9 GO:0045471 response to ethanol 11/969 137/18722 0.0985812497305895 0.294897316022931 RPL10A/EEF1B2/RPL15/GSTP1/RHOA/DNMT3A/EPS8/CDK1/GATA3/GGH/HPGD 11 GO:0043433 negative regulation of DNA-binding transcription factor activity 14/969 185/18722 0.0997050073507388 0.298088311450207 TMSB4X/UFL1/ANXA4/PURA/TCF7L2/BMP7/EIF2AK4/TAF3/NFKBIA/DDIT3/ID1/HMOX1/HES1/SRI 14 GO:0010506 regulation of autophagy 22/969 317/18722 0.0999413924518203 0.298624194941803 GAPDH/EEF1A1/MET/HSPB1/ROCK1/PSAP/UFL1/VPS13C/EXOC1/EIF4G1/MCL1/SMG1/ATP6V0E1/USP10/LARP1/WAC/RAB3GAP2/EP300/DDIT3/UVRAG/HMOX1/VDAC1 22 GO:0007062 sister chromatid cohesion 6/969 62/18722 0.100580775363001 0.300020052538266 ATRX/NIPBL/PDS5A/STAG1/SFPQ/CDC20 6 GO:0048488 synaptic vesicle endocytosis 6/969 62/18722 0.100580775363001 0.300020052538266 ACTG1/ROCK1/KIAA1109/STON1/CALM1/VAMP2 6 GO:0140238 presynaptic endocytosis 6/969 62/18722 0.100580775363001 0.300020052538266 ACTG1/ROCK1/KIAA1109/STON1/CALM1/VAMP2 6 GO:0002686 negative regulation of leukocyte migration 5/969 48/18722 0.101080203896551 0.300651761845974 MIF/DUSP1/MIA3/DPP4/HMOX1 5 GO:0035036 sperm-egg recognition 5/969 48/18722 0.101080203896551 0.300651761845974 ALDOA/SPESP1/VDAC2/LY6K/CCT8 5 GO:0045839 negative regulation of mitotic nuclear division 5/969 48/18722 0.101080203896551 0.300651761845974 DUSP1/TPR/BMP7/LCMT1/CCNB1 5 GO:0048146 positive regulation of fibroblast proliferation 5/969 48/18722 0.101080203896551 0.300651761845974 MIF/PRKDC/CDK6/ANXA2/CCNB1 5 GO:1905710 positive regulation of membrane permeability 5/969 48/18722 0.101080203896551 0.300651761845974 JAM3/HSPA1A/SLC9A1/NMT1/VDAC2 5 GO:0090087 regulation of peptide transport 15/969 202/18722 0.102321299938243 0.301797628040196 EGFR/LRP1/DYNLL1/GJA1/SOX4/ISL1/LRP5/PHPT1/KIF5B/SYT7/TCF7L2/HMGN3/DPP4/REST/SRI 15 GO:0021854 hypothalamus development 3/969 22/18722 0.102504934896928 0.301797628040196 NRP2/NRP1/UQCRQ 3 GO:0031061 negative regulation of histone methylation 3/969 22/18722 0.102504934896928 0.301797628040196 JARID2/MTF2/SUPT6H 3 GO:0031281 positive regulation of cyclase activity 3/969 22/18722 0.102504934896928 0.301797628040196 NF1/MAPK14/TIMP2 3 GO:0032069 regulation of nuclease activity 3/969 22/18722 0.102504934896928 0.301797628040196 RPS3/NPM1/HSPA1A 3 GO:0034629 cellular protein-containing complex localization 3/969 22/18722 0.102504934896928 0.301797628040196 AKAP9/DLG1/EZR 3 GO:0035089 establishment of apical/basal cell polarity 3/969 22/18722 0.102504934896928 0.301797628040196 FAT1/RHOA/CDC42 3 GO:0035357 peroxisome proliferator activated receptor signaling pathway 3/969 22/18722 0.102504934896928 0.301797628040196 ACTN4/CITED2/RXRA 3 GO:0044346 fibroblast apoptotic process 3/969 22/18722 0.102504934896928 0.301797628040196 BTG1/CHD8/STK17A 3 GO:0045048 protein insertion into ER membrane 3/969 22/18722 0.102504934896928 0.301797628040196 EMC1/CCDC47/EMC10 3 GO:0048169 regulation of long-term neuronal synaptic plasticity 3/969 22/18722 0.102504934896928 0.301797628040196 APP/RAB11A/KRAS 3 GO:0060343 trabecula formation 3/969 22/18722 0.102504934896928 0.301797628040196 FBN2/ADAMTS1/TGFBR3 3 GO:0060444 branching involved in mammary gland duct morphogenesis 3/969 22/18722 0.102504934896928 0.301797628040196 LRP5/TBX3/KDM5B 3 GO:0060713 labyrinthine layer morphogenesis 3/969 22/18722 0.102504934896928 0.301797628040196 ZFP36L1/SPINT1/BMP7 3 GO:0060965 negative regulation of gene silencing by miRNA 3/969 22/18722 0.102504934896928 0.301797628040196 NEAT1/KCNQ1OT1/NCOR1 3 GO:0071359 cellular response to dsRNA 3/969 22/18722 0.102504934896928 0.301797628040196 CAV1/NPM1/COLEC12 3 GO:1900120 regulation of receptor binding 3/969 22/18722 0.102504934896928 0.301797628040196 ANXA2/NRP1/PTPRF 3 GO:2000773 negative regulation of cellular senescence 3/969 22/18722 0.102504934896928 0.301797628040196 PRKDC/CDK6/YBX1 3 GO:0036503 ERAD pathway 9/969 107/18722 0.102606947353062 0.301927875488234 CAV1/HSP90B1/HSPA5/SEL1L/DNAJB14/CCDC47/FAF2/TMEM259/UBXN4 9 GO:0001894 tissue homeostasis 19/969 268/18722 0.102887796527426 0.302583919331643 EGFR/LAMC1/ITGB1/ACTG1/SLC2A1/GJA1/PRDX1/HSPB1/JAM3/NF1/TFRC/GCNT2/EPAS1/AKR1B1/DMD/LTBP3/VCL/HOMER1/KRAS 19 GO:0120032 regulation of plasma membrane bounded cell projection assembly 14/969 186/18722 0.102984954784453 0.302699310294461 CAV1/PFN1/KANK1/WASF2/NRP1/EPS8L1/PPP1R9A/ATMIN/PIK3R1/CDC42/EPS8/TACSTD2/KLF5/RAB17 14 GO:0048644 muscle organ morphogenesis 7/969 77/18722 0.103132242305866 0.302855504592888 LRP2/DSP/TGFBR3/ISL1/LY6E/ARID5B/RBPJ 7 GO:0007605 sensory perception of sound 12/969 154/18722 0.103153998885446 0.302855504592888 LRP2/GPX1/NIPBL/PGAP1/DIAPH1/TBL1X/TFAP2A/TRIOBP/SLC52A3/USP53/DDIT3/SERPINB6 12 GO:0008202 steroid metabolic process 22/969 319/18722 0.104921807931338 0.305384818436726 LRP2/APP/SF1/PBX1/CYP11A1/DHRS2/EGR1/LRP5/CYP19A1/PRLR/SLC27A2/DHCR24/ABCA1/AKR1B1/MBTPS1/NFE2L1/RXRA/OSBPL9/REST/ACBD3/NPC2/CYB5R1 22 GO:0008608 attachment of spindle microtubules to kinetochore 4/969 35/18722 0.105173423455634 0.305384818436726 EML4/CDC42/HNRNPU/CCNB1 4 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 4/969 35/18722 0.105173423455634 0.305384818436726 RPL11/EIF3H/WAC/TAF9 4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 4/969 35/18722 0.105173423455634 0.305384818436726 ISL1/UFL1/PARP1/LBH 4 GO:0033280 response to vitamin D 4/969 35/18722 0.105173423455634 0.305384818436726 ATP2B1/BMP7/TRIM24/STC2 4 GO:0034405 response to fluid shear stress 4/969 35/18722 0.105173423455634 0.305384818436726 GJA1/PLEC/ABCA1/CITED2 4 GO:0039694 viral RNA genome replication 4/969 35/18722 0.105173423455634 0.305384818436726 EEA1/MPHOSPH8/PCBP2/CDC42 4 GO:0043243 positive regulation of protein-containing complex disassembly 4/969 35/18722 0.105173423455634 0.305384818436726 IGF1R/EIF5A/SETX/UVRAG 4 GO:0071108 protein K48-linked deubiquitination 4/969 35/18722 0.105173423455634 0.305384818436726 USP34/USP9X/USP27X/USP8 4 GO:0090504 epiboly 4/969 35/18722 0.105173423455634 0.305384818436726 FERMT1/RHOA/RREB1/RHOC 4 GO:0106056 regulation of calcineurin-mediated signaling 4/969 35/18722 0.105173423455634 0.305384818436726 NFAT5/ATP2B4/SLC9A1/SPPL3 4 GO:2000403 positive regulation of lymphocyte migration 4/969 35/18722 0.105173423455634 0.305384818436726 APP/DOCK8/RHOA/WNK1 4 GO:0030216 keratinocyte differentiation 11/969 139/18722 0.106319141821782 0.305384818436726 ZFP36L1/DSP/ANXA1/PLEC/ROCK1/NCOA3/EXPH5/JAG1/RBPJ/SRSF6/KRT10 11 GO:0016239 positive regulation of macroautophagy 6/969 63/18722 0.106589010758034 0.305384818436726 LARP1/WAC/RAB3GAP2/UVRAG/HMOX1/VDAC1 6 GO:0022617 extracellular matrix disassembly 6/969 63/18722 0.106589010758034 0.305384818436726 LRP1/LAMC1/CTSV/MMP14/MMP15/DPP4 6 GO:0046902 regulation of mitochondrial membrane permeability 6/969 63/18722 0.106589010758034 0.305384818436726 PMAIP1/HSPA1A/SLC9A1/NMT1/DYNLT1/VDAC2 6 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 6/969 63/18722 0.106589010758034 0.305384818436726 PPP1R15A/PMAIP1/HSPA1A/XBP1/DDIT3/CASP4 6 GO:0033138 positive regulation of peptidyl-serine phosphorylation 9/969 108/18722 0.107106223321789 0.305384818436726 EGFR/AKAP9/CAV1/APP/MIF/TFRC/ATP2B4/EIF4G1/TXN 9 GO:0003093 regulation of glomerular filtration 2/969 11/18722 0.107995922666573 0.305384818436726 GJA1/GJA5 2 GO:0003174 mitral valve development 2/969 11/18722 0.107995922666573 0.305384818436726 SOX4/GJA5 2 GO:0003263 cardioblast proliferation 2/969 11/18722 0.107995922666573 0.305384818436726 ISL1/HES1 2 GO:0003264 regulation of cardioblast proliferation 2/969 11/18722 0.107995922666573 0.305384818436726 ISL1/HES1 2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 2/969 11/18722 0.107995922666573 0.305384818436726 UQCRH/UQCRQ 2 GO:0007042 lysosomal lumen acidification 2/969 11/18722 0.107995922666573 0.305384818436726 GRN/ATP6AP2 2 GO:0019048 modulation by virus of host process 2/969 11/18722 0.107995922666573 0.305384818436726 DAG1/RXRA 2 GO:0021561 facial nerve development 2/969 11/18722 0.107995922666573 0.305384818436726 NRP2/NRP1 2 GO:0021604 cranial nerve structural organization 2/969 11/18722 0.107995922666573 0.305384818436726 NRP2/NRP1 2 GO:0021610 facial nerve morphogenesis 2/969 11/18722 0.107995922666573 0.305384818436726 NRP2/NRP1 2 GO:0030432 peristalsis 2/969 11/18722 0.107995922666573 0.305384818436726 DLG1/TBX3 2 GO:0032329 serine transport 2/969 11/18722 0.107995922666573 0.305384818436726 SLC38A2/SLC1A5 2 GO:0033327 Leydig cell differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 SF1/TMF1 2 GO:0033483 gas homeostasis 2/969 11/18722 0.107995922666573 0.305384818436726 CAV1/GSTP1 2 GO:0033632 regulation of cell-cell adhesion mediated by integrin 2/969 11/18722 0.107995922666573 0.305384818436726 WNK1/DPP4 2 GO:0033690 positive regulation of osteoblast proliferation 2/969 11/18722 0.107995922666573 0.305384818436726 ITGAV/LRP5 2 GO:0034454 microtubule anchoring at centrosome 2/969 11/18722 0.107995922666573 0.305384818436726 PCM1/HOOK3 2 GO:0034650 cortisol metabolic process 2/969 11/18722 0.107995922666573 0.305384818436726 CYP11A1/REST 2 GO:0035457 cellular response to interferon-alpha 2/969 11/18722 0.107995922666573 0.305384818436726 TPR/GATA3 2 GO:0043589 skin morphogenesis 2/969 11/18722 0.107995922666573 0.305384818436726 ITGB4/ITGA6 2 GO:0045654 positive regulation of megakaryocyte differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 SCIN/RCOR1 2 GO:0045657 positive regulation of monocyte differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 JUN/ZFP36L1 2 GO:0048096 chromatin-mediated maintenance of transcription 2/969 11/18722 0.107995922666573 0.305384818436726 ARID1A/SERTAD1 2 GO:0048680 positive regulation of axon regeneration 2/969 11/18722 0.107995922666573 0.305384818436726 LRP1/GRN 2 GO:0048715 negative regulation of oligodendrocyte differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 NF1/HES1 2 GO:0051574 positive regulation of histone H3-K9 methylation 2/969 11/18722 0.107995922666573 0.305384818436726 RIF1/JARID2 2 GO:0055015 ventricular cardiac muscle cell development 2/969 11/18722 0.107995922666573 0.305384818436726 CDK1/CCNB1 2 GO:0060837 blood vessel endothelial cell differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 NRP1/RBPJ 2 GO:0070933 histone H4 deacetylation 2/969 11/18722 0.107995922666573 0.305384818436726 RCOR1/REST 2 GO:0072173 metanephric tubule morphogenesis 2/969 11/18722 0.107995922666573 0.305384818436726 LGR4/HES1 2 GO:0072205 metanephric collecting duct development 2/969 11/18722 0.107995922666573 0.305384818436726 DLG5/AKR1B1 2 GO:0097050 type B pancreatic cell apoptotic process 2/969 11/18722 0.107995922666573 0.305384818436726 TCF7L2/SRSF6 2 GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/969 11/18722 0.107995922666573 0.305384818436726 ATP2B4/PDE4B 2 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 2/969 11/18722 0.107995922666573 0.305384818436726 N4BP2L2/HES1 2 GO:1902188 positive regulation of viral release from host cell 2/969 11/18722 0.107995922666573 0.305384818436726 DDB1/CAV2 2 GO:1902667 regulation of axon guidance 2/969 11/18722 0.107995922666573 0.305384818436726 MYCBP2/NRP1 2 GO:1903897 regulation of PERK-mediated unfolded protein response 2/969 11/18722 0.107995922666573 0.305384818436726 HSPA5/PPP1R15A 2 GO:1903961 positive regulation of anion transmembrane transport 2/969 11/18722 0.107995922666573 0.305384818436726 TCAF1/ITGB1 2 GO:1904181 positive regulation of membrane depolarization 2/969 11/18722 0.107995922666573 0.305384818436726 ANK3/PARP1 2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2/969 11/18722 0.107995922666573 0.305384818436726 HSPA5/DDIT3 2 GO:2000392 regulation of lamellipodium morphogenesis 2/969 11/18722 0.107995922666573 0.305384818436726 KANK1/RREB1 2 GO:2000615 regulation of histone H3-K9 acetylation 2/969 11/18722 0.107995922666573 0.305384818436726 ZNF451/GATA3 2 GO:2000644 regulation of receptor catabolic process 2/969 11/18722 0.107995922666573 0.305384818436726 ANXA2/MYLIP 2 GO:0007622 rhythmic behavior 5/969 49/18722 0.108047556312573 0.305384818436726 ZFHX3/EGR1/ADRB1/NCOR1/NAGLU 5 GO:0010823 negative regulation of mitochondrion organization 5/969 49/18722 0.108047556312573 0.305384818436726 GPX1/HSPA1A/HUWE1/TFRC/GHITM 5 GO:0045778 positive regulation of ossification 5/969 49/18722 0.108047556312573 0.305384818436726 FBN2/ATP2B1/NIPBL/TFAP2A/BMP7 5 GO:0060986 endocrine hormone secretion 5/969 49/18722 0.108047556312573 0.305384818436726 GJA1/TBX3/TRPV6/TMF1/GATA3 5 GO:0072666 establishment of protein localization to vacuole 5/969 49/18722 0.108047556312573 0.305384818436726 GCC2/VPS13C/ZFYVE16/VPS13A/GNPTAB 5 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 5/969 49/18722 0.108047556312573 0.305384818436726 GPX1/PMAIP1/LGALS3/CFLAR/HMOX1 5 GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 5/969 49/18722 0.108047556312573 0.305384818436726 JUN/ADAMTS1/GJA1/DDX39B/HPGD 5 GO:1904752 regulation of vascular associated smooth muscle cell migration 5/969 49/18722 0.108047556312573 0.305384818436726 LRP1/IQGAP1/ADAMTS1/RHOA/GNA12 5 GO:0007589 body fluid secretion 8/969 93/18722 0.108447223665394 0.305964819157265 EGFR/CAV1/ANXA2/PRLR/KCNN4/COPA/WNK1/XBP1 8 GO:0033273 response to vitamin 8/969 93/18722 0.108447223665394 0.305964819157265 EGFR/ATP2B1/GSTP1/SRSF2/DNMT3A/BMP7/TRIM24/STC2 8 GO:0008306 associative learning 7/969 78/18722 0.108545498415149 0.305964819157265 FOS/APP/ITGB1/NF1/BTG2/KRAS/TPBG 7 GO:0019319 hexose biosynthetic process 7/969 78/18722 0.108545498415149 0.305964819157265 TPI1/DDB1/RANBP2/AKR1B1/EP300/SLC35B4/PGK1 7 GO:0090559 regulation of membrane permeability 7/969 78/18722 0.108545498415149 0.305964819157265 JAM3/PMAIP1/HSPA1A/SLC9A1/NMT1/DYNLT1/VDAC2 7 GO:0033673 negative regulation of kinase activity 17/969 237/18722 0.109116617325657 0.307408863689426 CAV1/GADD45B/NR2F2/PLEC/HSPB1/DUSP1/NPM1/GSTP1/LRP5/PPIA/GNAQ/NF1/LATS2/ADAR/BMP7/WNK1/HNRNPU 17 GO:0006575 cellular modified amino acid metabolic process 14/969 188/18722 0.109739101802409 0.308663372453922 CLIC3/CROT/GSTO1/GPX4/GSTP1/GPX1/CLIC1/PCYOX1/IDH1/GCLM/GATA3/SLC19A1/GGH/GSTA3 14 GO:0030308 negative regulation of cell growth 14/969 188/18722 0.109739101802409 0.308663372453922 SEMA6A/SEMA6D/GJA1/ENO1/NRP1/BTG1/HSPA1A/SMARCA2/YY1/VGLL4/RTN4/SPAG9/HSPA1B/NDUFA13 14 GO:0060491 regulation of cell projection assembly 14/969 188/18722 0.109739101802409 0.308663372453922 CAV1/PFN1/KANK1/WASF2/NRP1/EPS8L1/PPP1R9A/ATMIN/PIK3R1/CDC42/EPS8/TACSTD2/KLF5/RAB17 14 GO:0007292 female gamete generation 11/969 140/18722 0.110317170593686 0.310122395654977 RPS6/LGR5/ADAMTS1/USP9X/DIAPH2/NRIP1/ZFX/YTHDC1/HPGD/CCNB1/AURKA 11 GO:0009267 cellular response to starvation 12/969 156/18722 0.110642475200673 0.310869664192859 JUN/HSPA5/SLC2A1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/CTSV/EIF2AK4/XBP1/ITFG2/DNAJC15 12 GO:0032410 negative regulation of transporter activity 9/969 109/18722 0.111714831648212 0.313713976460805 CAV1/C4orf3/GSTO1/ANK3/CALM1/GOPC/YWHAE/CALM2/SRI 9 GO:0034655 nucleobase-containing compound catabolic process 27/969 407/18722 0.11193673489436 0.314168301051518 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/PUM1/TNRC6B/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/PDE4B/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HNRNPC/HNRNPU/SSB 27 GO:0017156 calcium-ion regulated exocytosis 6/969 64/18722 0.112778377832149 0.315178243601511 SCIN/SYT7/TRPV6/REST/VAMP2/VAMP3 6 GO:1900076 regulation of cellular response to insulin stimulus 6/969 64/18722 0.112778377832149 0.315178243601511 ATP2B1/KANK1/IGF2/SORBS1/ESRRA/PTPRE 6 GO:0001738 morphogenesis of a polarized epithelium 8/969 94/18722 0.113491411556465 0.315178243601511 LAMA5/ACTG1/DLG5/ZNRF3/FAT1/AHI1/RHOA/CDC42 8 GO:2000027 regulation of animal organ morphogenesis 10/969 125/18722 0.113563321141047 0.315178243601511 LGR4/MAGED1/ZNRF3/AHI1/RHOA/BMP7/CITED2/CDC42/TACSTD2/GATA3 10 GO:0006622 protein targeting to lysosome 3/969 23/18722 0.113565889314539 0.315178243601511 GCC2/ZFYVE16/GNPTAB 3 GO:0010888 negative regulation of lipid storage 3/969 23/18722 0.113565889314539 0.315178243601511 ITGAV/ABCA1/NFKBIA 3 GO:0018279 protein N-linked glycosylation via asparagine 3/969 23/18722 0.113565889314539 0.315178243601511 RPN2/FUT8/OST4 3 GO:0019430 removal of superoxide radicals 3/969 23/18722 0.113565889314539 0.315178243601511 PRDX1/SOD3/BMP7 3 GO:0021884 forebrain neuron development 3/969 23/18722 0.113565889314539 0.315178243601511 NRP2/NRP1/UQCRQ 3 GO:0030539 male genitalia development 3/969 23/18722 0.113565889314539 0.315178243601511 LGR4/DHCR24/TBX3 3 GO:0031338 regulation of vesicle fusion 3/969 23/18722 0.113565889314539 0.315178243601511 ANXA1/ANXA2/KIF5B 3 GO:0040019 positive regulation of embryonic development 3/969 23/18722 0.113565889314539 0.315178243601511 CFL1/AMOT/B4GALT5 3 GO:0042026 protein refolding 3/969 23/18722 0.113565889314539 0.315178243601511 HSPA5/HSPA1A/HSPA1B 3 GO:0045662 negative regulation of myoblast differentiation 3/969 23/18722 0.113565889314539 0.315178243601511 MBNL3/TBX3/DDIT3 3 GO:0071636 positive regulation of transforming growth factor beta production 3/969 23/18722 0.113565889314539 0.315178243601511 CD46/FERMT1/ATP6AP2 3 GO:1900273 positive regulation of long-term synaptic potentiation 3/969 23/18722 0.113565889314539 0.315178243601511 APP/EIF2AK4/MME 3 GO:2001169 regulation of ATP biosynthetic process 3/969 23/18722 0.113565889314539 0.315178243601511 ENO1/TMSB4X/PARP1 3 GO:0003230 cardiac atrium development 4/969 36/18722 0.113744004483821 0.315178243601511 SOX4/ISL1/MDM4/GJA5 4 GO:0009225 nucleotide-sugar metabolic process 4/969 36/18722 0.113744004483821 0.315178243601511 EXTL2/FUT8/UGP2/NANS 4 GO:0010092 specification of animal organ identity 4/969 36/18722 0.113744004483821 0.315178243601511 LRP2/ISL1/GLI3/RBPJ 4 GO:0010923 negative regulation of phosphatase activity 4/969 36/18722 0.113744004483821 0.315178243601511 BOD1L1/PPP1R15A/ROCK1/LGALS3 4 GO:0030224 monocyte differentiation 4/969 36/18722 0.113744004483821 0.315178243601511 JUN/ZFP36L1/CDK6/FOXP1 4 GO:0060251 regulation of glial cell proliferation 4/969 36/18722 0.113744004483821 0.315178243601511 EGFR/UFL1/DICER1/HES1 4 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/969 36/18722 0.113744004483821 0.315178243601511 HUWE1/NMT1/NPEPPS/UBE2L3 4 GO:0016241 regulation of macroautophagy 11/969 141/18722 0.114400765251314 0.316441475687583 GAPDH/VPS13C/EXOC1/SMG1/ATP6V0E1/LARP1/WAC/RAB3GAP2/UVRAG/HMOX1/VDAC1 11 GO:0007030 Golgi organization 12/969 157/18722 0.114502646483968 0.316441475687583 GOLGB1/AKAP9/LMAN1/TRIP11/GCC2/ARHGAP21/HUWE1/CAMSAP2/ARFGEF1/CDC42/OBSL1/CDK1 12 GO:0070646 protein modification by small protein removal 12/969 157/18722 0.114502646483968 0.316441475687583 USP34/USP47/USP9X/USP22/USP10/USP27X/USP53/USP48/EIF3F/USP8/CDK1/UCHL3 12 GO:1902107 positive regulation of leukocyte differentiation 12/969 157/18722 0.114502646483968 0.316441475687583 JUN/FOS/CD46/ZFP36L1/PRKDC/SOX4/ANXA1/GLI3/RHOA/MMP14/XBP1/GATA3 12 GO:1903708 positive regulation of hemopoiesis 12/969 157/18722 0.114502646483968 0.316441475687583 JUN/FOS/CD46/ZFP36L1/PRKDC/SOX4/ANXA1/GLI3/RHOA/MMP14/XBP1/GATA3 12 GO:0030098 lymphocyte differentiation 25/969 374/18722 0.115042949668879 0.316810963410308 CD46/RPS6/ZFP36L1/ITGB1/PBX1/PRKDC/RPL22/SOX4/ANXA1/EGR1/HECTD1/CTSL/GLI3/PIK3R1/RHOA/FOXP1/MMP14/YY1/EP300/XBP1/ITFG2/RBPJ/IRF2BP2/GATA3/TPD52 25 GO:0007080 mitotic metaphase plate congression 5/969 50/18722 0.115242564378683 0.316810963410308 RAB11A/EML4/KPNB1/HNRNPU/CCNB1 5 GO:0007632 visual behavior 5/969 50/18722 0.115242564378683 0.316810963410308 APP/ITGB1/DYNLRB1/NF1/KRAS 5 GO:0038202 TORC1 signaling 5/969 50/18722 0.115242564378683 0.316810963410308 SMG1/LARP1/WAC/ITFG2/SEC13 5 GO:0043268 positive regulation of potassium ion transport 5/969 50/18722 0.115242564378683 0.316810963410308 AKAP9/DLG1/KIF5B/KCNN4/WNK1 5 GO:0045814 negative regulation of gene expression, epigenetic 5/969 50/18722 0.115242564378683 0.316810963410308 TPR/MPHOSPH8/CREBZF/DNMT3A/BAZ2A 5 GO:0060688 regulation of morphogenesis of a branching structure 5/969 50/18722 0.115242564378683 0.316810963410308 LGR4/MAGED1/BMP7/RTN4/TACSTD2 5 GO:1903747 regulation of establishment of protein localization to mitochondrion 5/969 50/18722 0.115242564378683 0.316810963410308 LMAN1/HUWE1/NMT1/NPEPPS/UBE2L3 5 GO:1904036 negative regulation of epithelial cell apoptotic process 5/969 50/18722 0.115242564378683 0.316810963410308 TCF7L2/CFLAR/SRSF6/GATA3/HMOX1 5 GO:1904738 vascular associated smooth muscle cell migration 5/969 50/18722 0.115242564378683 0.316810963410308 LRP1/IQGAP1/ADAMTS1/RHOA/GNA12 5 GO:0009408 response to heat 9/969 110/18722 0.116431953208472 0.319576358964011 TPR/HSPA1A/DNAJB1/SLC52A3/EP300/PDCD6/HSPA1B/HMOX1/YWHAE 9 GO:0090174 organelle membrane fusion 9/969 110/18722 0.116431953208472 0.319576358964011 ANXA1/ANXA2/EEA1/KIF5B/SYT7/UVRAG/VAMP2/CAV2/VAMP3 9 GO:1905954 positive regulation of lipid localization 9/969 110/18722 0.116431953208472 0.319576358964011 LRP1/CAV1/PLIN2/ANXA2/CYP19A1/ABCA1/NFKBIA/RXRA/TMF1 9 GO:0051216 cartilage development 14/969 190/18722 0.116751385064492 0.320284902019441 GLG1/TRIP11/ITGB8/GLI3/EFEMP1/SCIN/SMAD5/CREB3L2/NFIB/LTBP3/ESRRA/BMP7/MAPK14/SERPINH1 14 GO:0071103 DNA conformation change 20/969 290/18722 0.117627772571778 0.322519800346332 ATRX/ANXA1/HMGB3/NPM1/BRD2/HP1BP3/CHD2/RAD50/PURA/CHD4/RSF1/CHD8/HMGA1/SETX/CHD6/BAZ2A/BANF1/CDK1/NUSAP1/CCNB1 20 GO:0031929 TOR signaling 10/969 126/18722 0.117990436737711 0.323334187557912 RPS6/RICTOR/SMG1/GNA12/LARP1/WAC/ITFG2/PDCD6/GATA3/SEC13 10 GO:0008544 epidermis development 22/969 324/18722 0.118048532311614 0.323334187557912 EGFR/SVEP1/LAMA5/ZFP36L1/DSP/LGR5/ANXA1/LGR4/PLEC/ROCK1/NCOA3/YBX1/FERMT1/EXPH5/MCOLN3/TRIOBP/JAG1/RBPJ/FLOT2/SRSF6/HES1/KRT10 22 GO:0030516 regulation of axon extension 8/969 95/18722 0.11866029139273 0.324839540502046 LRP1/GOLGA4/SEMA6A/MACF1/SEMA6D/NRP1/RAB11A/RTN4 8 GO:0045682 regulation of epidermis development 6/969 65/18722 0.119145741878374 0.325827130851064 ZFP36L1/ROCK1/NCOA3/SRSF6/HES1/KRT10 6 GO:0051310 metaphase plate congression 6/969 65/18722 0.119145741878374 0.325827130851064 DYNC1H1/RAB11A/EML4/KPNB1/HNRNPU/CCNB1 6 GO:0021766 hippocampus development 7/969 80/18722 0.119815586663394 0.327487581539171 CDK6/KIF5B/GLI3/ATP2B4/UQCRQ/BTG2/ANXA3 7 GO:0046700 heterocycle catabolic process 29/969 445/18722 0.120097835514113 0.328087448194852 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/TET2/PUM1/TNRC6B/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/PDE4B/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HMOX1/HNRNPC/HNRNPU/SSB 29 GO:1903169 regulation of calcium ion transmembrane transport 12/969 159/18722 0.122453162316159 0.329755129000384 AHNAK/C4orf3/GSTO1/DIAPH1/PDE4B/SLC9A1/DMD/CALM1/YWHAE/VDAC1/CALM2/SRI 12 GO:0048565 digestive tract development 10/969 127/18722 0.122512230212309 0.329755129000384 EGFR/LGR4/IL6ST/NIPBL/GLI3/AHI1/CHD8/KLF5/HES1/CCNB1 10 GO:0001990 regulation of systemic arterial blood pressure by hormone 4/969 37/18722 0.12261088195556 0.329755129000384 ENPEP/RHOA/MME/ATP6AP2 4 GO:0003176 aortic valve development 4/969 37/18722 0.12261088195556 0.329755129000384 ROCK1/JAG1/RBPJ/GATA3 4 GO:0006862 nucleotide transport 4/969 37/18722 0.12261088195556 0.329755129000384 GJA1/SLC25A36/SLC25A6/SLC19A1 4 GO:0014904 myotube cell development 4/969 37/18722 0.12261088195556 0.329755129000384 PLEC/GPX1/HOMER1/CAV2 4 GO:0021532 neural tube patterning 4/969 37/18722 0.12261088195556 0.329755129000384 GLI3/TMEM107/ATP6AP2/HES1 4 GO:0032570 response to progesterone 4/969 37/18722 0.12261088195556 0.329755129000384 FOS/CAV1/FOSB/CLDN4 4 GO:0045616 regulation of keratinocyte differentiation 4/969 37/18722 0.12261088195556 0.329755129000384 ZFP36L1/ROCK1/NCOA3/SRSF6 4 GO:0048009 insulin-like growth factor receptor signaling pathway 4/969 37/18722 0.12261088195556 0.329755129000384 CRIM1/IGF1R/PHIP/PIK3R1 4 GO:0048846 axon extension involved in axon guidance 4/969 37/18722 0.12261088195556 0.329755129000384 NRP2/SEMA6A/SEMA6D/NRP1 4 GO:0060306 regulation of membrane repolarization 4/969 37/18722 0.12261088195556 0.329755129000384 AKAP9/CAV1/GJA5/YWHAE 4 GO:0060428 lung epithelium development 4/969 37/18722 0.12261088195556 0.329755129000384 NFIB/RBPJ/CDC42/SRSF6 4 GO:1902284 neuron projection extension involved in neuron projection guidance 4/969 37/18722 0.12261088195556 0.329755129000384 NRP2/SEMA6A/SEMA6D/NRP1 4 GO:1902745 positive regulation of lamellipodium organization 4/969 37/18722 0.12261088195556 0.329755129000384 WASF2/PIK3R1/RREB1/CDC42 4 GO:1905332 positive regulation of morphogenesis of an epithelium 4/969 37/18722 0.12261088195556 0.329755129000384 GJA1/LGR4/MAGED1/GATA3 4 GO:0009948 anterior/posterior axis specification 5/969 51/18722 0.122659459406035 0.329755129000384 WLS/PGAP1/TBX3/DDIT3/AURKA 5 GO:0010874 regulation of cholesterol efflux 5/969 51/18722 0.122659459406035 0.329755129000384 LRP1/CAV1/ABCA1/NFKBIA/RXRA 5 GO:0014009 glial cell proliferation 5/969 51/18722 0.122659459406035 0.329755129000384 EGFR/SOX4/UFL1/DICER1/HES1 5 GO:0045104 intermediate filament cytoskeleton organization 5/969 51/18722 0.122659459406035 0.329755129000384 KRT18/DSP/MACF1/DST/PLEC 5 GO:0031023 microtubule organizing center organization 11/969 143/18722 0.122822761673243 0.329755129000384 NPM1/GCC2/CEP152/PCM1/PPP1R12A/XPO1/UVRAG/CDK1/RANBP1/UXT/AURKA 11 GO:0035282 segmentation 8/969 96/18722 0.123952447916989 0.329755129000384 NRP2/PRKDC/NRP1/TBX3/IRX2/MTF2/EP300/RBPJ 8 GO:0051304 chromosome separation 8/969 96/18722 0.123952447916989 0.329755129000384 DUSP1/TPR/ANAPC11/NEK6/UBE2C/LCMT1/CCNB1/PTTG1 8 GO:0007035 vacuolar acidification 3/969 24/18722 0.125054432903099 0.329755129000384 GRN/ATP6V0E1/ATP6AP2 3 GO:0018196 peptidyl-asparagine modification 3/969 24/18722 0.125054432903099 0.329755129000384 RPN2/FUT8/OST4 3 GO:0031639 plasminogen activation 3/969 24/18722 0.125054432903099 0.329755129000384 ENO1/DHCR24/PGK1 3 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 3/969 24/18722 0.125054432903099 0.329755129000384 PUM1/ANKRD17/PUM2 3 GO:0051570 regulation of histone H3-K9 methylation 3/969 24/18722 0.125054432903099 0.329755129000384 ATRX/RIF1/JARID2 3 GO:0061162 establishment of monopolar cell polarity 3/969 24/18722 0.125054432903099 0.329755129000384 FAT1/RHOA/CDC42 3 GO:0070841 inclusion body assembly 3/969 24/18722 0.125054432903099 0.329755129000384 HSPA1A/DNAJB1/HSPA1B 3 GO:0072010 glomerular epithelium development 3/969 24/18722 0.125054432903099 0.329755129000384 IQGAP1/JAG1/CD24 3 GO:0090343 positive regulation of cell aging 3/969 24/18722 0.125054432903099 0.329755129000384 PAWR/HMGA1/KRAS 3 GO:2000209 regulation of anoikis 3/969 24/18722 0.125054432903099 0.329755129000384 CAV1/ITGB1/MCL1 3 GO:2000679 positive regulation of transcription regulatory region DNA binding 3/969 24/18722 0.125054432903099 0.329755129000384 PARP1/EP300/GATA3 3 GO:2001026 regulation of endothelial cell chemotaxis 3/969 24/18722 0.125054432903099 0.329755129000384 MET/HSPB1/TMSB4X 3 GO:0000491 small nucleolar ribonucleoprotein complex assembly 2/969 12/18722 0.12531452089452 0.329755129000384 SNU13/TAF9 2 GO:0002674 negative regulation of acute inflammatory response 2/969 12/18722 0.12531452089452 0.329755129000384 ASH1L/GSTP1 2 GO:0002903 negative regulation of B cell apoptotic process 2/969 12/18722 0.12531452089452 0.329755129000384 SLC39A10/FOXP1 2 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 2/969 12/18722 0.12531452089452 0.329755129000384 HSPA5/SEC62 2 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 2/969 12/18722 0.12531452089452 0.329755129000384 LRP1/PTPN12 2 GO:0021978 telencephalon regionalization 2/969 12/18722 0.12531452089452 0.329755129000384 ADGRG1/TRA2B 2 GO:0030157 pancreatic juice secretion 2/969 12/18722 0.12531452089452 0.329755129000384 COPA/WNK1 2 GO:0030238 male sex determination 2/969 12/18722 0.12531452089452 0.329755129000384 SF1/MAP3K4 2 GO:0031453 positive regulation of heterochromatin assembly 2/969 12/18722 0.12531452089452 0.329755129000384 TPR/MPHOSPH8 2 GO:0033127 regulation of histone phosphorylation 2/969 12/18722 0.12531452089452 0.329755129000384 RPS6KA5/CCNB1 2 GO:0033629 negative regulation of cell adhesion mediated by integrin 2/969 12/18722 0.12531452089452 0.329755129000384 JAM3/WNK1 2 GO:0034086 maintenance of sister chromatid cohesion 2/969 12/18722 0.12531452089452 0.329755129000384 ATRX/NIPBL 2 GO:0034088 maintenance of mitotic sister chromatid cohesion 2/969 12/18722 0.12531452089452 0.329755129000384 ATRX/NIPBL 2 GO:0042118 endothelial cell activation 2/969 12/18722 0.12531452089452 0.329755129000384 PPIA/FOXP1 2 GO:0043696 dedifferentiation 2/969 12/18722 0.12531452089452 0.329755129000384 CDK6/NCOA3 2 GO:0043697 cell dedifferentiation 2/969 12/18722 0.12531452089452 0.329755129000384 CDK6/NCOA3 2 GO:0045602 negative regulation of endothelial cell differentiation 2/969 12/18722 0.12531452089452 0.329755129000384 JAG1/ID1 2 GO:0045605 negative regulation of epidermal cell differentiation 2/969 12/18722 0.12531452089452 0.329755129000384 SRSF6/HES1 2 GO:0045683 negative regulation of epidermis development 2/969 12/18722 0.12531452089452 0.329755129000384 SRSF6/HES1 2 GO:0048548 regulation of pinocytosis 2/969 12/18722 0.12531452089452 0.329755129000384 CAV1/CDC42 2 GO:0051001 negative regulation of nitric-oxide synthase activity 2/969 12/18722 0.12531452089452 0.329755129000384 CAV1/ATP2B4 2 GO:0051340 regulation of ligase activity 2/969 12/18722 0.12531452089452 0.329755129000384 TMSB4X/GCLM 2 GO:0061430 bone trabecula morphogenesis 2/969 12/18722 0.12531452089452 0.329755129000384 FBN2/PLXNB1 2 GO:0070572 positive regulation of neuron projection regeneration 2/969 12/18722 0.12531452089452 0.329755129000384 LRP1/GRN 2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 2/969 12/18722 0.12531452089452 0.329755129000384 BRD4/CDK12 2 GO:0071257 cellular response to electrical stimulus 2/969 12/18722 0.12531452089452 0.329755129000384 SLC9A1/REST 2 GO:0071287 cellular response to manganese ion 2/969 12/18722 0.12531452089452 0.329755129000384 APP/HSPA5 2 GO:0072015 glomerular visceral epithelial cell development 2/969 12/18722 0.12531452089452 0.329755129000384 IQGAP1/JAG1 2 GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/969 12/18722 0.12531452089452 0.329755129000384 GATA3/CD24 2 GO:0072520 seminiferous tubule development 2/969 12/18722 0.12531452089452 0.329755129000384 ADGRG1/ATRX 2 GO:0120263 positive regulation of heterochromatin organization 2/969 12/18722 0.12531452089452 0.329755129000384 TPR/MPHOSPH8 2 GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2/969 12/18722 0.12531452089452 0.329755129000384 MET/PAWR 2 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 2/969 12/18722 0.12531452089452 0.329755129000384 NRP1/PLXNB1 2 GO:1903332 regulation of protein folding 2/969 12/18722 0.12531452089452 0.329755129000384 HSPA5/GRN 2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 2/969 12/18722 0.12531452089452 0.329755129000384 EGFR/DDX5 2 GO:1904667 negative regulation of ubiquitin protein ligase activity 2/969 12/18722 0.12531452089452 0.329755129000384 RPL11/RPS20 2 GO:2000035 regulation of stem cell division 2/969 12/18722 0.12531452089452 0.329755129000384 NCOA3/LBH 2 GO:2000105 positive regulation of DNA-dependent DNA replication 2/969 12/18722 0.12531452089452 0.329755129000384 ATRX/STOML2 2 GO:0021954 central nervous system neuron development 7/969 81/18722 0.125668286522321 0.330072252039422 NRP2/MYCBP2/NRP1/NFIB/B4GALT5/UQCRQ/BTG2 7 GO:0019229 regulation of vasoconstriction 6/969 66/18722 0.125687673470809 0.330072252039422 EGFR/ATP2B1/CAV1/GJA1/RHOA/GJA5 6 GO:0042446 hormone biosynthetic process 6/969 66/18722 0.125687673470809 0.330072252039422 CYP11A1/EGR1/CYP19A1/AKR1B1/REST/STC2 6 GO:0072678 T cell migration 6/969 66/18722 0.125687673470809 0.330072252039422 APP/PLEC/DOCK8/CD99/RHOA/WNK1 6 GO:0035601 protein deacylation 9/969 112/18722 0.126187891117464 0.331053172178647 NIPBL/KDM5A/MORF4L2/TBL1X/RCOR1/EP300/BAZ2A/REST/SFPQ 9 GO:0043406 positive regulation of MAP kinase activity 9/969 112/18722 0.126187891117464 0.331053172178647 EGFR/IQGAP1/RPS3/AKAP13/MAGED1/MAP3K4/TAOK3/KRAS/CD24 9 GO:0007612 learning 11/969 144/18722 0.127160044226247 0.333436222341379 JUN/FOS/APP/ITGB1/NF1/EIF2AK4/BTG2/KRAS/VDAC1/TPBG/ARF4 11 GO:0001935 endothelial cell proliferation 14/969 193/18722 0.127750164236625 0.334815626028386 NRP2/CAV1/IGF2/GJA1/NR2F2/DLG1/NRP1/NF1/RICTOR/MMP14/PDCD6/EMC10/HMOX1/CAV2 14 GO:0035335 peptidyl-tyrosine dephosphorylation 8/969 97/18722 0.129366319501653 0.338604470452231 DUSP6/DUSP1/PTPN14/PTPRF/PTPRA/PTPN12/PTPRE/CDKN3 8 GO:0120162 positive regulation of cold-induced thermogenesis 8/969 97/18722 0.129366319501653 0.338604470452231 CAV1/DYNC1H1/GJA1/IGF1R/ADRB1/PRLR/EPAS1/ESRRG 8 GO:0098739 import across plasma membrane 13/969 177/18722 0.129390188957732 0.338604470452231 LRP2/ITGB1/SLC39A10/SLC2A1/DLG1/ATP2B4/SLC5A3/SLC9A1/SLC1A5/TRPV6/WNK1/SLC3A2/SLC19A1 13 GO:0010718 positive regulation of epithelial to mesenchymal transition 5/969 52/18722 0.130292048086303 0.340113008640868 ISL1/GCNT2/JAG1/TCF7L2/BMP7 5 GO:0030514 negative regulation of BMP signaling pathway 5/969 52/18722 0.130292048086303 0.340113008640868 FBN1/LRP2/CRIM1/TRIM33/HTRA1 5 GO:0045103 intermediate filament-based process 5/969 52/18722 0.130292048086303 0.340113008640868 KRT18/DSP/MACF1/DST/PLEC 5 GO:0051496 positive regulation of stress fiber assembly 5/969 52/18722 0.130292048086303 0.340113008640868 S100A10/NRP1/RHOA/CDC42/RHOC 5 GO:0072132 mesenchyme morphogenesis 5/969 52/18722 0.130292048086303 0.340113008640868 ISL1/TBX3/BMP7/MDM4/RBPJ 5 GO:0098657 import into cell 16/969 227/18722 0.130738994337075 0.341109328210461 LRP2/ITGB1/SLC39A10/SLC2A1/SLC38A1/DLG1/SLC27A2/ATP2B4/SLC5A3/SLC9A1/SLC1A5/TRPV6/WNK1/SLC6A4/SLC3A2/SLC19A1 16 GO:0001819 positive regulation of cytokine production 30/969 467/18722 0.131072298288366 0.341391724216827 GAPDH/LRP1/CD46/APP/MIF/RPS3/ANXA1/HSPB1/IL6ST/ISL1/EGR1/CADM1/HSPA1A/SETD2/FERMT1/SPTBN1/PDE4B/PIK3R1/FOXP1/TRIM56/MAPK14/XBP1/DDIT3/TMF1/KPNA6/HSPA1B/ATP6AP2/GATA3/HMOX1/STOML2 30 GO:0061351 neural precursor cell proliferation 11/969 145/18722 0.131580655780955 0.341391724216827 LRP2/ADGRG1/SPINT1/RERE/GLI3/NF1/PCM1/RHOA/SLC6A4/HOOK3/BTG2 11 GO:0046364 monosaccharide biosynthetic process 7/969 82/18722 0.131663000929834 0.341391724216827 TPI1/DDB1/RANBP2/AKR1B1/EP300/SLC35B4/PGK1 7 GO:0060395 SMAD protein signal transduction 7/969 82/18722 0.131663000929834 0.341391724216827 JUN/FOS/LRP1/PARP1/SPTBN1/SMAD5/BMP7 7 GO:0001825 blastocyst formation 4/969 38/18722 0.131761788699836 0.341391724216827 JUNB/SUPT6H/CITED2/RTN4 4 GO:0007094 mitotic spindle assembly checkpoint signaling 4/969 38/18722 0.131761788699836 0.341391724216827 DUSP1/TPR/LCMT1/CCNB1 4 GO:0010742 macrophage derived foam cell differentiation 4/969 38/18722 0.131761788699836 0.341391724216827 ITGAV/ABCA1/EP300/NFKBIA 4 GO:0032941 secretion by tissue 4/969 38/18722 0.131761788699836 0.341391724216827 EGFR/KCNN4/COPA/WNK1 4 GO:0035136 forelimb morphogenesis 4/969 38/18722 0.131761788699836 0.341391724216827 ATRX/NIPBL/TBX3/TFAP2A 4 GO:0071173 spindle assembly checkpoint signaling 4/969 38/18722 0.131761788699836 0.341391724216827 DUSP1/TPR/LCMT1/CCNB1 4 GO:0071174 mitotic spindle checkpoint signaling 4/969 38/18722 0.131761788699836 0.341391724216827 DUSP1/TPR/LCMT1/CCNB1 4 GO:0071392 cellular response to estradiol stimulus 4/969 38/18722 0.131761788699836 0.341391724216827 EGFR/NCOA3/NRIP1/CFLAR 4 GO:0090077 foam cell differentiation 4/969 38/18722 0.131761788699836 0.341391724216827 ITGAV/ABCA1/EP300/NFKBIA 4 GO:1901031 regulation of response to reactive oxygen species 4/969 38/18722 0.131761788699836 0.341391724216827 MET/TXN/PAWR/BMP7 4 GO:0009880 embryonic pattern specification 6/969 67/18722 0.132400463197744 0.342587929462902 NRP2/NRP1/PGAP1/TBX3/SMAD5/BMP7 6 GO:0072665 protein localization to vacuole 6/969 67/18722 0.132400463197744 0.342587929462902 GCC2/VPS13C/ZFYVE16/VPS13A/GNPTAB/RTN4 6 GO:0070588 calcium ion transmembrane transport 21/969 312/18722 0.132420133470161 0.342587929462902 AHNAK/ATP2B1/ITGAV/C4orf3/GSTO1/ANXA2/DIAPH1/ATP2B4/PDE4B/SLC9A1/MCOLN3/TRPV6/DMD/CALM1/DDIT3/AFG3L2/YWHAE/VDAC1/CALM2/SRI/STOML2 21 GO:0044270 cellular nitrogen compound catabolic process 29/969 451/18722 0.13464965199645 0.348183612733027 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/TET2/PUM1/TNRC6B/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/PDE4B/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HMOX1/HNRNPC/HNRNPU/SSB 29 GO:0070301 cellular response to hydrogen peroxide 8/969 98/18722 0.134900202206581 0.34860906727529 MET/RHOB/RPS3/ANXA1/TXN/PAWR/SETX/CDK1 8 GO:0021953 central nervous system neuron differentiation 12/969 162/18722 0.134947597225012 0.34860906727529 NRP2/MYCBP2/LMO4/SOX4/ISL1/NRP1/GLI3/NFIB/B4GALT5/UQCRQ/BTG2/HES1 12 GO:0048813 dendrite morphogenesis 11/969 146/18722 0.136083866430701 0.349608156321673 ITGB1/CFL1/CUX1/RERE/NRP1/KIDINS220/PPP1R9A/CDC42/OBSL1/ID1/TPBG 11 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9/969 114/18722 0.136365240065507 0.349608156321673 TGFBR3/PARP1/FERMT1/CSNK2B/BMP7/EP300/RBPJ/CITED2/HES1 9 GO:1901800 positive regulation of proteasomal protein catabolic process 9/969 114/18722 0.136365240065507 0.349608156321673 CAV1/HECTD1/HSPA1A/DDA1/TMEM259/HSPA1B/CDC20/PSMC1/AURKA 9 GO:0007098 centrosome cycle 10/969 130/18722 0.13663740781634 0.349608156321673 NPM1/CEP152/PCM1/PPP1R12A/XPO1/UVRAG/CDK1/RANBP1/UXT/AURKA 10 GO:0006469 negative regulation of protein kinase activity 15/969 212/18722 0.136854640281154 0.349608156321673 CAV1/GADD45B/NR2F2/PLEC/HSPB1/DUSP1/NPM1/GSTP1/LRP5/PPIA/GNAQ/NF1/LATS2/ADAR/BMP7 15 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 3/969 25/18722 0.136939895903265 0.349608156321673 GJA1/RHOA/GJA5 3 GO:0010560 positive regulation of glycoprotein biosynthetic process 3/969 25/18722 0.136939895903265 0.349608156321673 TCF7L2/PAWR/ARFGEF1 3 GO:0010842 retina layer formation 3/969 25/18722 0.136939895903265 0.349608156321673 AHI1/TFAP2A/OBSL1 3 GO:0021846 cell proliferation in forebrain 3/969 25/18722 0.136939895903265 0.349608156321673 GLI3/PCM1/HOOK3 3 GO:0033622 integrin activation 3/969 25/18722 0.136939895903265 0.349608156321673 JAM3/TLN1/FERMT1 3 GO:0046039 GTP metabolic process 3/969 25/18722 0.136939895903265 0.349608156321673 RAN/RHOA/IMPDH2 3 GO:0048596 embryonic camera-type eye morphogenesis 3/969 25/18722 0.136939895903265 0.349608156321673 TFAP2A/BMP7/CITED2 3 GO:0060074 synapse maturation 3/969 25/18722 0.136939895903265 0.349608156321673 PFN1/CLSTN1/CDC20 3 GO:0061339 establishment or maintenance of monopolar cell polarity 3/969 25/18722 0.136939895903265 0.349608156321673 FAT1/RHOA/CDC42 3 GO:0062009 secondary palate development 3/969 25/18722 0.136939895903265 0.349608156321673 TGFBR3/DLG1/ITGB8 3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3/969 25/18722 0.136939895903265 0.349608156321673 HSPA1A/NFKBIA/HSPA1B 3 GO:0071450 cellular response to oxygen radical 3/969 25/18722 0.136939895903265 0.349608156321673 PRDX1/SOD3/BMP7 3 GO:0071451 cellular response to superoxide 3/969 25/18722 0.136939895903265 0.349608156321673 PRDX1/SOD3/BMP7 3 GO:1900078 positive regulation of cellular response to insulin stimulus 3/969 25/18722 0.136939895903265 0.349608156321673 IGF2/SORBS1/ESRRA 3 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 3/969 25/18722 0.136939895903265 0.349608156321673 EGFR/DDX5/NCOR1 3 GO:1903959 regulation of anion transmembrane transport 3/969 25/18722 0.136939895903265 0.349608156321673 TCAF1/ITGB1/GOPC 3 GO:1904385 cellular response to angiotensin 3/969 25/18722 0.136939895903265 0.349608156321673 CAV1/ROCK1/AHCYL1 3 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 3/969 25/18722 0.136939895903265 0.349608156321673 LRP1/IQGAP1/ADAMTS1 3 GO:1905048 regulation of metallopeptidase activity 3/969 25/18722 0.136939895903265 0.349608156321673 LRP1/CLDN4/TIMP2 3 GO:0032210 regulation of telomere maintenance via telomerase 5/969 53/18722 0.1381337459851 0.352139978789334 MAP3K4/HNRNPA1/HNRNPC/HNRNPU/CCT8 5 GO:0045806 negative regulation of endocytosis 5/969 53/18722 0.1381337459851 0.352139978789334 CAV1/ITGAV/LRPAP1/LGALS3/ATXN2 5 GO:0071320 cellular response to cAMP 5/969 53/18722 0.1381337459851 0.352139978789334 AKAP9/APP/HSPA5/ZFP36L1/EZR 5 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 6/969 68/18722 0.139280136797209 0.354543592256316 ALDOA/ENO1/TMSB4X/PARP1/STOML2/IMPDH2 6 GO:0051148 negative regulation of muscle cell differentiation 6/969 68/18722 0.139280136797209 0.354543592256316 IGF2/YBX1/BHLHE41/ANKRD17/YY1/XBP1 6 GO:0061912 selective autophagy 6/969 68/18722 0.139280136797209 0.354543592256316 UFL1/VPS13C/HUWE1/RB1CC1/VDAC1/UFC1 6 GO:0030838 positive regulation of actin filament polymerization 8/969 99/18722 0.140552254079433 0.356100077805184 PFN1/IQGAP2/WASF2/ARPC3/DLG1/SCIN/RICTOR/RHOA 8 GO:0051153 regulation of striated muscle cell differentiation 8/969 99/18722 0.140552254079433 0.356100077805184 YBX1/MORF4L2/BHLHE41/MMP14/DDX39B/YY1/MAPK14/XBP1 8 GO:0060041 retina development in camera-type eye 11/969 147/18722 0.14066887987435 0.356100077805184 ATP2B1/RPL24/LRP5/NRP1/ATP2B4/AHI1/MAN2A1/TFAP2A/NAGLU/OBSL1/IMPDH2 11 GO:0031507 heterochromatin assembly 4/969 39/18722 0.141183917382695 0.356100077805184 TPR/MPHOSPH8/DNMT3A/BAZ2A 4 GO:0031577 spindle checkpoint signaling 4/969 39/18722 0.141183917382695 0.356100077805184 DUSP1/TPR/LCMT1/CCNB1 4 GO:0051154 negative regulation of striated muscle cell differentiation 4/969 39/18722 0.141183917382695 0.356100077805184 YBX1/BHLHE41/YY1/XBP1 4 GO:0071548 response to dexamethasone 4/969 39/18722 0.141183917382695 0.356100077805184 EGFR/NR3C1/CFLAR/USP8 4 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 4/969 39/18722 0.141183917382695 0.356100077805184 GSTO1/SLC9A1/CALM1/CALM2 4 GO:2000249 regulation of actin cytoskeleton reorganization 4/969 39/18722 0.141183917382695 0.356100077805184 IQGAP2/NRP1/PHPT1/CDC42 4 GO:0071897 DNA biosynthetic process 13/969 180/18722 0.14160854202413 0.356100077805184 GJA1/DUSP1/MAP3K4/PTGES3/RAD50/HNRNPA1/USP10/DDX39B/HNRNPC/HNRNPU/NHP2/CCT8/NOP10 13 GO:0001768 establishment of T cell polarity 2/969 13/18722 0.143231078206126 0.356100077805184 DOCK8/FLOT2 2 GO:0001778 plasma membrane repair 2/969 13/18722 0.143231078206126 0.356100077805184 SYT7/MYOF 2 GO:0003334 keratinocyte development 2/969 13/18722 0.143231078206126 0.356100077805184 PLEC/EXPH5 2 GO:0005513 detection of calcium ion 2/969 13/18722 0.143231078206126 0.356100077805184 CALM1/CALM2 2 GO:0006000 fructose metabolic process 2/969 13/18722 0.143231078206126 0.356100077805184 ALDOA/AKR1B1 2 GO:0010635 regulation of mitochondrial fusion 2/969 13/18722 0.143231078206126 0.356100077805184 HUWE1/TFRC 2 GO:0010960 magnesium ion homeostasis 2/969 13/18722 0.143231078206126 0.356100077805184 EGFR/ANK3 2 GO:0014842 regulation of skeletal muscle satellite cell proliferation 2/969 13/18722 0.143231078206126 0.356100077805184 PAXBP1/CFLAR 2 GO:0021514 ventral spinal cord interneuron differentiation 2/969 13/18722 0.143231078206126 0.356100077805184 LMO4/GLI3 2 GO:0021554 optic nerve development 2/969 13/18722 0.143231078206126 0.356100077805184 RPL24/GLI3 2 GO:0021819 layer formation in cerebral cortex 2/969 13/18722 0.143231078206126 0.356100077805184 ADGRG1/GLI3 2 GO:0032352 positive regulation of hormone metabolic process 2/969 13/18722 0.143231078206126 0.356100077805184 EGR1/GATA3 2 GO:0032530 regulation of microvillus organization 2/969 13/18722 0.143231078206126 0.356100077805184 KLF5/EZR 2 GO:0034112 positive regulation of homotypic cell-cell adhesion 2/969 13/18722 0.143231078206126 0.356100077805184 IL6ST/ANK3 2 GO:0036302 atrioventricular canal development 2/969 13/18722 0.143231078206126 0.356100077805184 TBX3/RBPJ 2 GO:0042538 hyperosmotic salinity response 2/969 13/18722 0.143231078206126 0.356100077805184 AKR1B1/EFHD1 2 GO:0043970 histone H3-K9 acetylation 2/969 13/18722 0.143231078206126 0.356100077805184 ZNF451/GATA3 2 GO:0044794 positive regulation by host of viral process 2/969 13/18722 0.143231078206126 0.356100077805184 CFL1/CAV2 2 GO:0048711 positive regulation of astrocyte differentiation 2/969 13/18722 0.143231078206126 0.356100077805184 IL6ST/HES1 2 GO:0048820 hair follicle maturation 2/969 13/18722 0.143231078206126 0.356100077805184 FERMT1/RBPJ 2 GO:0051451 myoblast migration 2/969 13/18722 0.143231078206126 0.356100077805184 ANXA1/ROCK1 2 GO:0060347 heart trabecula formation 2/969 13/18722 0.143231078206126 0.356100077805184 ADAMTS1/TGFBR3 2 GO:0060707 trophoblast giant cell differentiation 2/969 13/18722 0.143231078206126 0.356100077805184 NR2F2/HECTD1 2 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 2/969 13/18722 0.143231078206126 0.356100077805184 HSPA1A/HSPA1B 2 GO:0070486 leukocyte aggregation 2/969 13/18722 0.143231078206126 0.356100077805184 S100A9/BMP7 2 GO:0070914 UV-damage excision repair 2/969 13/18722 0.143231078206126 0.356100077805184 DDB1/XPC 2 GO:0071696 ectodermal placode development 2/969 13/18722 0.143231078206126 0.356100077805184 NRP1/TBX3 2 GO:0072310 glomerular epithelial cell development 2/969 13/18722 0.143231078206126 0.356100077805184 IQGAP1/JAG1 2 GO:0072393 microtubule anchoring at microtubule organizing center 2/969 13/18722 0.143231078206126 0.356100077805184 PCM1/HOOK3 2 GO:0090161 Golgi ribbon formation 2/969 13/18722 0.143231078206126 0.356100077805184 TRIP11/GCC2 2 GO:0098840 protein transport along microtubule 2/969 13/18722 0.143231078206126 0.356100077805184 HSPB1/KIF5B 2 GO:0099118 microtubule-based protein transport 2/969 13/18722 0.143231078206126 0.356100077805184 HSPB1/KIF5B 2 GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 2/969 13/18722 0.143231078206126 0.356100077805184 ATP2B4/PDE4B 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/969 13/18722 0.143231078206126 0.356100077805184 PIK3R1/XBP1 2 GO:1900272 negative regulation of long-term synaptic potentiation 2/969 13/18722 0.143231078206126 0.356100077805184 APP/PPP1R9A 2 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/969 13/18722 0.143231078206126 0.356100077805184 VPS13C/HUWE1 2 GO:1905244 regulation of modification of synaptic structure 2/969 13/18722 0.143231078206126 0.356100077805184 RHOA/CDC42 2 GO:1905269 positive regulation of chromatin organization 2/969 13/18722 0.143231078206126 0.356100077805184 TPR/MPHOSPH8 2 GO:1990403 embryonic brain development 2/969 13/18722 0.143231078206126 0.356100077805184 RPL10/TRA2B 2 GO:0042594 response to starvation 14/969 197/18722 0.143298596177632 0.356100077805184 JUN/HSPA5/SLC2A1/SLC38A2/PMAIP1/HNRNPA1/TNRC6A/CTSV/LARP1/EIF2AK4/XBP1/ITFG2/DDIT3/DNAJC15 14 GO:0050680 negative regulation of epithelial cell proliferation 12/969 164/18722 0.143649767837564 0.356803083041401 CAV1/GJA1/NR2F2/TGFBR3/CDK6/ISL1/DLG1/MAGED1/NF1/NFIB/GATA3/CAV2 12 GO:0006835 dicarboxylic acid transport 7/969 84/18722 0.144068065053609 0.356993697472811 LRP2/SLC26A2/ITGB1/GJA1/SLC1A5/SLC19A1/SLC13A3 7 GO:0006970 response to osmotic stress 7/969 84/18722 0.144068065053609 0.356993697472811 EGFR/ZFP36L1/NFAT5/SLC2A1/AKR1B1/EFHD1/SERPINB6 7 GO:0042310 vasoconstriction 7/969 84/18722 0.144068065053609 0.356993697472811 EGFR/ATP2B1/CAV1/GJA1/RHOA/SLC6A4/GJA5 7 GO:1900542 regulation of purine nucleotide metabolic process 7/969 84/18722 0.144068065053609 0.356993697472811 APP/ENO1/TMSB4X/PARP1/NCOR1/EP300/PGAM1 7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7/969 84/18722 0.144068065053609 0.356993697472811 RPL26/PRKDC/SOX4/DLG1/CTDSPL/BRD7/WAC 7 GO:0009150 purine ribonucleotide metabolic process 24/969 368/18722 0.145398821486757 0.360120493407483 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0010524 positive regulation of calcium ion transport into cytosol 5/969 54/18722 0.1461776109635 0.361209840065889 CAV1/GSTO1/CALM1/CALM2/SRI 5 GO:0032330 regulation of chondrocyte differentiation 5/969 54/18722 0.1461776109635 0.361209840065889 GLG1/GLI3/EFEMP1/SCIN/LTBP3 5 GO:0072348 sulfur compound transport 5/969 54/18722 0.1461776109635 0.361209840065889 SLC26A2/GJA1/SLC13A4/SLC19A3/SLC13A3 5 GO:1902743 regulation of lamellipodium organization 5/969 54/18722 0.1461776109635 0.361209840065889 KANK1/WASF2/PIK3R1/RREB1/CDC42 5 GO:0009145 purine nucleoside triphosphate biosynthetic process 6/969 69/18722 0.146322470612225 0.361209840065889 ALDOA/ENO1/TMSB4X/PARP1/STOML2/IMPDH2 6 GO:0015807 L-amino acid transport 6/969 69/18722 0.146322470612225 0.361209840065889 ITGB1/SLC38A1/SLC38A2/SLC1A5/SLC7A6/SLC3A2 6 GO:0033344 cholesterol efflux 6/969 69/18722 0.146322470612225 0.361209840065889 LRP1/CAV1/ABCA1/NFKBIA/RXRA/NPC2 6 GO:0033559 unsaturated fatty acid metabolic process 9/969 116/18722 0.146953485305927 0.362425160079647 CYP2J2/MIF/ANXA1/GPX4/GSTP1/GPX1/PTGES3/AKR1B1/HPGD 9 GO:0098732 macromolecule deacylation 9/969 116/18722 0.146953485305927 0.362425160079647 NIPBL/KDM5A/MORF4L2/TBL1X/RCOR1/EP300/BAZ2A/REST/SFPQ 9 GO:0050900 leukocyte migration 24/969 369/18722 0.14834514763709 0.365684783750675 CSF3R/APP/MIF/ITGB1/ANXA1/PLEC/DUSP1/DOCK8/ROCK1/MIA3/PPIA/JAM3/S100A9/PDE4B/CD99/RHOA/MMP14/LGALS3/WNK1/DPP4/CDC42/EPS8/GATA3/HMOX1 24 GO:0001573 ganglioside metabolic process 3/969 26/18722 0.149191404774483 0.366560546004442 ITGB8/B4GALT5/HEXA 3 GO:0034114 regulation of heterotypic cell-cell adhesion 3/969 26/18722 0.149191404774483 0.366560546004442 GCNT2/BMP7/WNK1 3 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 3/969 26/18722 0.149191404774483 0.366560546004442 HSPA1A/NFKBIA/HSPA1B 3 GO:0048843 negative regulation of axon extension involved in axon guidance 3/969 26/18722 0.149191404774483 0.366560546004442 SEMA6A/SEMA6D/NRP1 3 GO:0060352 cell adhesion molecule production 3/969 26/18722 0.149191404774483 0.366560546004442 CAV1/PPIA/COLEC12 3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 3/969 26/18722 0.149191404774483 0.366560546004442 EGFR/DDX5/NCOR1 3 GO:0099637 neurotransmitter receptor transport 3/969 26/18722 0.149191404774483 0.366560546004442 RAB11A/CLSTN1/VAMP2 3 GO:1905039 carboxylic acid transmembrane transport 11/969 149/18722 0.150080804667894 0.368572502440984 LRP2/ITGB1/SLC2A1/SLC38A1/SLC38A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2/SLC19A1/SLC13A3 11 GO:0072384 organelle transport along microtubule 7/969 85/18722 0.150472763242481 0.368590594816068 ARMCX3/DYNC1H1/ARHGAP21/KIF5B/RAB6A/CDC42/UXT 7 GO:0007339 binding of sperm to zona pellucida 4/969 40/18722 0.150864003503936 0.368590594816068 ALDOA/VDAC2/LY6K/CCT8 4 GO:0030501 positive regulation of bone mineralization 4/969 40/18722 0.150864003503936 0.368590594816068 FBN2/ATP2B1/TFAP2A/BMP7 4 GO:0045022 early endosome to late endosome transport 4/969 40/18722 0.150864003503936 0.368590594816068 EEA1/HOOK2/HOOK3/EZR 4 GO:0045777 positive regulation of blood pressure 4/969 40/18722 0.150864003503936 0.368590594816068 NR2F2/ADRB1/RHOA/WNK1 4 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 4/969 40/18722 0.150864003503936 0.368590594816068 DUSP1/TPR/LCMT1/CCNB1 4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 4/969 40/18722 0.150864003503936 0.368590594816068 GSTO1/CALM1/CALM2/SRI 4 GO:0071276 cellular response to cadmium ion 4/969 40/18722 0.150864003503936 0.368590594816068 JUN/EGFR/FOS/HMOX1 4 GO:0072210 metanephric nephron development 4/969 40/18722 0.150864003503936 0.368590594816068 LGR4/EGR1/IRX2/HES1 4 GO:1901998 toxin transport 4/969 40/18722 0.150864003503936 0.368590594816068 HSPA5/NRP1/ANTXR2/CCT8 4 GO:2000781 positive regulation of double-strand break repair 4/969 40/18722 0.150864003503936 0.368590594816068 FUS/PRKDC/RIF1/PARP1 4 GO:0042098 T cell proliferation 14/969 199/18722 0.151443822036941 0.369824653532148 CD46/RPS6/IGF2/DLG5/RPS3/ANXA1/IL6ST/DOCK8/DLG1/TFRC/LGALS3/PAWR/CD24/HES1 14 GO:0046328 regulation of JNK cascade 10/969 133/18722 0.151581402194003 0.369824653532148 EGFR/APP/GADD45B/GSTP1/IGF1R/RB1CC1/NCOR1/TAOK3/TAOK1/CDC42 10 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 10/969 133/18722 0.151581402194003 0.369824653532148 CAV1/CTSC/HECTD1/HSPA1A/DDA1/TMEM259/HSPA1B/CDC20/PSMC1/AURKA 10 GO:0042102 positive regulation of T cell proliferation 8/969 101/18722 0.152202834801965 0.37099440982979 CD46/IGF2/RPS3/ANXA1/IL6ST/TFRC/CD24/HES1 8 GO:0051963 regulation of synapse assembly 8/969 101/18722 0.152202834801965 0.37099440982979 APP/DLG5/PPP1R9A/EIF4G1/SETD5/CLSTN1/TPBG/RAB17 8 GO:1903828 negative regulation of cellular protein localization 9/969 117/18722 0.152397959134415 0.37129684589112 LMAN1/MAGED1/CLTC/HECTD1/FERMT1/LATS2/TXN/PPFIA1/GOPC 9 GO:0003407 neural retina development 6/969 70/18722 0.153523007286911 0.373689443913085 ATP2B1/ATP2B4/AHI1/TFAP2A/NAGLU/OBSL1 6 GO:0060415 muscle tissue morphogenesis 6/969 70/18722 0.153523007286911 0.373689443913085 LRP2/DSP/TGFBR3/ISL1/LY6E/RBPJ 6 GO:1903825 organic acid transmembrane transport 11/969 150/18722 0.154905801796706 0.3768797580026 LRP2/ITGB1/SLC2A1/SLC38A1/SLC38A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2/SLC19A1/SLC13A3 11 GO:0006140 regulation of nucleotide metabolic process 7/969 86/18722 0.157008189532438 0.381462016967234 APP/ENO1/TMSB4X/PARP1/NCOR1/EP300/PGAM1 7 GO:0009798 axis specification 7/969 86/18722 0.157008189532438 0.381462016967234 WLS/PGAP1/TBX3/AHI1/CITED2/DDIT3/AURKA 7 GO:0034103 regulation of tissue remodeling 7/969 86/18722 0.157008189532438 0.381462016967234 EGFR/ROCK1/SUCO/NF1/TFRC/SYT7/LTBP3 7 GO:0055074 calcium ion homeostasis 29/969 460/18722 0.158381900448816 0.383947480180226 TPT1/ATP2B1/LRP1/CAV1/HSP90B1/ITGAV/APP/GSTO1/GJA1/GTF2I/DIAPH1/ATP2B4/ATP13A3/MCOLN3/TRPV6/CCDC47/DMD/CALM1/DDIT3/SPPL3/TRIM24/AFG3L2/CD24/YWHAE/CALM2/CAV2/SRI/STC2/STOML2 29 GO:0030902 hindbrain development 11/969 151/18722 0.159808775902899 0.383947480180226 HSPA5/ITGB1/WLS/RERE/AHI1/NFIB/BMP7/SLC6A4/NAGLU/UQCRQ/HES1 11 GO:0010907 positive regulation of glucose metabolic process 4/969 41/18722 0.160788404549604 0.383947480180226 IGF2/DDB1/PMAIP1/SORBS1 4 GO:0048286 lung alveolus development 4/969 41/18722 0.160788404549604 0.383947480180226 PTGES3/MAN2A1/LTBP3/MAN1A2 4 GO:0033555 multicellular organismal response to stress 6/969 71/18722 0.160877071628698 0.383947480180226 GJA1/ADRB1/VWA1/EIF4G1/DPP4/VDAC1 6 GO:0000212 meiotic spindle organization 2/969 14/18722 0.161637470306598 0.383947480180226 ATRX/AURKA 2 GO:0001767 establishment of lymphocyte polarity 2/969 14/18722 0.161637470306598 0.383947480180226 DOCK8/FLOT2 2 GO:0001921 positive regulation of receptor recycling 2/969 14/18722 0.161637470306598 0.383947480180226 ANXA2/VAMP3 2 GO:0002091 negative regulation of receptor internalization 2/969 14/18722 0.161637470306598 0.383947480180226 LRPAP1/ATXN2 2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 2/969 14/18722 0.161637470306598 0.383947480180226 TRIP11/SERPINH1 2 GO:0006999 nuclear pore organization 2/969 14/18722 0.161637470306598 0.383947480180226 TPR/RTN4 2 GO:0007100 mitotic centrosome separation 2/969 14/18722 0.161637470306598 0.383947480180226 RANBP1/AURKA 2 GO:0010421 hydrogen peroxide-mediated programmed cell death 2/969 14/18722 0.161637470306598 0.383947480180226 MET/PAWR 2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 2/969 14/18722 0.161637470306598 0.383947480180226 EPN2/PDCD6 2 GO:0035672 oligopeptide transmembrane transport 2/969 14/18722 0.161637470306598 0.383947480180226 GJA1/SLC13A3 2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/969 14/18722 0.161637470306598 0.383947480180226 LRP1/PTPN12 2 GO:0036444 calcium import into the mitochondrion 2/969 14/18722 0.161637470306598 0.383947480180226 AFG3L2/VDAC1 2 GO:0043922 negative regulation by host of viral transcription 2/969 14/18722 0.161637470306598 0.383947480180226 JUN/REST 2 GO:0044154 histone H3-K14 acetylation 2/969 14/18722 0.161637470306598 0.383947480180226 PHF14/GATA3 2 GO:0045579 positive regulation of B cell differentiation 2/969 14/18722 0.161637470306598 0.383947480180226 MMP14/XBP1 2 GO:0048875 chemical homeostasis within a tissue 2/969 14/18722 0.161637470306598 0.383947480180226 EPAS1/HOMER1 2 GO:0051984 positive regulation of chromosome segregation 2/969 14/18722 0.161637470306598 0.383947480180226 HNRNPU/CCNB1 2 GO:0060576 intestinal epithelial cell development 2/969 14/18722 0.161637470306598 0.383947480180226 IL6ST/KLF5 2 GO:0070141 response to UV-A 2/969 14/18722 0.161637470306598 0.383947480180226 EGFR/MME 2 GO:0070986 left/right axis specification 2/969 14/18722 0.161637470306598 0.383947480180226 AHI1/CITED2 2 GO:0071236 cellular response to antibiotic 2/969 14/18722 0.161637470306598 0.383947480180226 HSPA5/SLC9A1 2 GO:0071481 cellular response to X-ray 2/969 14/18722 0.161637470306598 0.383947480180226 NIPBL/GATA3 2 GO:0072160 nephron tubule epithelial cell differentiation 2/969 14/18722 0.161637470306598 0.383947480180226 GATA3/CD24 2 GO:0072176 nephric duct development 2/969 14/18722 0.161637470306598 0.383947480180226 AHI1/GATA3 2 GO:0072531 pyrimidine-containing compound transmembrane transport 2/969 14/18722 0.161637470306598 0.383947480180226 SLC25A36/SLC19A3 2 GO:0090128 regulation of synapse maturation 2/969 14/18722 0.161637470306598 0.383947480180226 CLSTN1/CDC20 2 GO:1901077 regulation of relaxation of muscle 2/969 14/18722 0.161637470306598 0.383947480180226 PDE4B/SRI 2 GO:1902036 regulation of hematopoietic stem cell differentiation 2/969 14/18722 0.161637470306598 0.383947480180226 N4BP2L2/PRKDC 2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/969 14/18722 0.161637470306598 0.383947480180226 MIF/TAF9 2 GO:1903894 regulation of IRE1-mediated unfolded protein response 2/969 14/18722 0.161637470306598 0.383947480180226 HSPA5/UFL1 2 GO:1904294 positive regulation of ERAD pathway 2/969 14/18722 0.161637470306598 0.383947480180226 CAV1/TMEM259 2 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 2/969 14/18722 0.161637470306598 0.383947480180226 VPS13C/HUWE1 2 GO:1905049 negative regulation of metallopeptidase activity 2/969 14/18722 0.161637470306598 0.383947480180226 LRP1/TIMP2 2 GO:2001171 positive regulation of ATP biosynthetic process 2/969 14/18722 0.161637470306598 0.383947480180226 ENO1/TMSB4X 2 GO:0003171 atrioventricular valve development 3/969 27/18722 0.161778100144825 0.383947480180226 SOX4/MDM4/GJA5 3 GO:0003272 endocardial cushion formation 3/969 27/18722 0.161778100144825 0.383947480180226 TBX3/BMP7/RBPJ 3 GO:0009651 response to salt stress 3/969 27/18722 0.161778100144825 0.383947480180226 ZFP36L1/AKR1B1/EFHD1 3 GO:0034698 response to gonadotropin 3/969 27/18722 0.161778100144825 0.383947480180226 TGFBR3/CTSV/GCLM 3 GO:0035459 vesicle cargo loading 3/969 27/18722 0.161778100144825 0.383947480180226 MIA3/SEC31A/SEC13 3 GO:0039529 RIG-I signaling pathway 3/969 27/18722 0.161778100144825 0.383947480180226 PUM1/ANKRD17/PUM2 3 GO:0042104 positive regulation of activated T cell proliferation 3/969 27/18722 0.161778100144825 0.383947480180226 IGF2/RPS3/CD24 3 GO:1902914 regulation of protein polyubiquitination 3/969 27/18722 0.161778100144825 0.383947480180226 TRIM44/PPIA/UBR5 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/969 27/18722 0.161778100144825 0.383947480180226 PARP1/MCL1/REST 3 GO:1903205 regulation of hydrogen peroxide-induced cell death 3/969 27/18722 0.161778100144825 0.383947480180226 MET/TXN/PAWR 3 GO:1903319 positive regulation of protein maturation 3/969 27/18722 0.161778100144825 0.383947480180226 ENO1/SOX4/MMP14 3 GO:1903421 regulation of synaptic vesicle recycling 3/969 27/18722 0.161778100144825 0.383947480180226 ROCK1/CALM1/VAMP2 3 GO:0001101 response to acid chemical 10/969 135/18722 0.16198329995397 0.384259975287992 KRT8/PLEC/GSTP1/UFL1/ATP2B4/RHOA/AKR1B1/DNMT3A/XBP1/GCLM 10 GO:0022029 telencephalon cell migration 5/969 56/18722 0.162842483782433 0.385947764284351 LAMB1/ADGRG1/GLI3/RHOA/RTN4 5 GO:0051784 negative regulation of nuclear division 5/969 56/18722 0.162842483782433 0.385947764284351 DUSP1/TPR/BMP7/LCMT1/CCNB1 5 GO:0009913 epidermal cell differentiation 14/969 202/18722 0.16411341309876 0.388783634113381 ZFP36L1/DSP/ANXA1/PLEC/ROCK1/NCOA3/EXPH5/MCOLN3/TRIOBP/JAG1/RBPJ/SRSF6/HES1/KRT10 14 GO:0000209 protein polyubiquitination 16/969 236/18722 0.164468184111003 0.389447544251972 TTC3/NHLRC3/TRIM44/PPIA/SKP1/HECTD1/HUWE1/KLHL42/DDA1/ANAPC11/UBR5/TRIM56/UBE2C/NPEPPS/UBE2L3/UBE2A 16 GO:0016125 sterol metabolic process 11/969 152/18722 0.164788616935758 0.389853015892381 APP/CYP11A1/LRP5/CYP19A1/DHCR24/ABCA1/MBTPS1/NFE2L1/RXRA/NPC2/CYB5R1 11 GO:0098754 detoxification 11/969 152/18722 0.164788616935758 0.389853015892381 GPX3/GSTO1/PRDX6/PRDX1/GPX4/GSTP1/GPX1/S100A9/TXN/SOD3/BMP7 11 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 13/969 186/18722 0.167836362291499 0.396883633183428 GAPDH/WLS/GJA1/BRD4/AKAP13/TFRC/RHOA/ANKRD17/NEK6/CFLAR/EEF1D/HMOX1/RHOC 13 GO:0006839 mitochondrial transport 17/969 254/18722 0.168034130013896 0.397171580032846 LMAN1/SLC25A36/PMAIP1/HSPA1A/HUWE1/SLC9A1/NMT1/SLC25A6/NPEPPS/UBE2L3/AFG3L2/VDAC1/DYNLT1/DNAJC15/NDUFA13/VDAC2/STOML2 17 GO:0043903 regulation of biological process involved in symbiotic interaction 6/969 72/18722 0.168379786565995 0.397628904018928 CAV1/ITGAV/DDB1/LY6E/P4HB/CAV2 6 GO:0070227 lymphocyte apoptotic process 6/969 72/18722 0.168379786565995 0.397628904018928 RPS6/SLC39A10/DOCK8/GLI3/FOXP1/LGALS3 6 GO:0006304 DNA modification 9/969 120/18722 0.16931253522856 0.399470568444449 FOS/ATRX/TET2/PARP1/USP9X/MPHOSPH8/DNMT3A/BAZ2A/GATA3 9 GO:0072655 establishment of protein localization to mitochondrion 9/969 120/18722 0.16931253522856 0.399470568444449 LMAN1/HUWE1/CALM1/NMT1/DDIT3/NPEPPS/UBE2L3/DNAJC15/NDUFA13 9 GO:1901890 positive regulation of cell junction assembly 8/969 104/18722 0.170511508112773 0.401685716432605 CAV1/IQGAP1/DLG5/S100A10/ROCK1/NRP1/CLSTN1/TPBG 8 GO:0000413 protein peptidyl-prolyl isomerization 4/969 42/18722 0.170943175152337 0.401685716432605 NKTR/PPIA/RANBP2/PPIG 4 GO:0021879 forebrain neuron differentiation 4/969 42/18722 0.170943175152337 0.401685716432605 NRP2/NRP1/UQCRQ/HES1 4 GO:0030574 collagen catabolic process 4/969 42/18722 0.170943175152337 0.401685716432605 ITGB1/CTSL/MMP14/MMP15 4 GO:0032467 positive regulation of cytokinesis 4/969 42/18722 0.170943175152337 0.401685716432605 PKN2/RHOA/SVIL/CDC42 4 GO:0051602 response to electrical stimulus 4/969 42/18722 0.170943175152337 0.401685716432605 AKAP9/SLC9A1/BTG2/REST 4 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 4/969 42/18722 0.170943175152337 0.401685716432605 DUSP1/TPR/LCMT1/CCNB1 4 GO:2000404 regulation of T cell migration 4/969 42/18722 0.170943175152337 0.401685716432605 APP/DOCK8/RHOA/WNK1 4 GO:2001222 regulation of neuron migration 4/969 42/18722 0.170943175152337 0.401685716432605 SEMA6A/ADGRG1/NIPBL/ZNF609 4 GO:0006754 ATP biosynthetic process 5/969 57/18722 0.171448115371999 0.401968528907164 ALDOA/ENO1/TMSB4X/PARP1/STOML2 5 GO:0016447 somatic recombination of immunoglobulin gene segments 5/969 57/18722 0.171448115371999 0.401968528907164 PRKDC/RIF1/TFRC/YY1/SUPT6H 5 GO:0030219 megakaryocyte differentiation 5/969 57/18722 0.171448115371999 0.401968528907164 WASF2/SCIN/RCOR1/EP300/PRMT1 5 GO:0050891 multicellular organismal water homeostasis 5/969 57/18722 0.171448115371999 0.401968528907164 MET/PLEC/CLDN4/AKR1B1/STMN1 5 GO:0060760 positive regulation of response to cytokine stimulus 5/969 57/18722 0.171448115371999 0.401968528907164 TRIM44/HSPA1A/HSPA1B/TAF9/CASP4 5 GO:0050671 positive regulation of lymphocyte proliferation 10/969 137/18722 0.172723847577132 0.404777949523807 CD46/MIF/SLC39A10/IGF2/RPS3/ANXA1/IL6ST/TFRC/CD24/HES1 10 GO:0034470 ncRNA processing 25/969 395/18722 0.174488109641922 0.40732793499617 RPS21/RPL14/RPS6/RPS25/RPL26/RPS8/RPL10A/RPS16/RPL7A/RPL11/PRKDC/RPL27/RPL7/DDX17/RPL35/DICER1/INTS6/ADAR/AGO2/SNU13/EBNA1BP2/NHP2/NOP10/SSB/TPRKB 25 GO:0006874 cellular calcium ion homeostasis 28/969 448/18722 0.17462167557373 0.40732793499617 TPT1/ATP2B1/LRP1/CAV1/HSP90B1/ITGAV/APP/GSTO1/GJA1/GTF2I/DIAPH1/ATP2B4/ATP13A3/MCOLN3/TRPV6/CCDC47/DMD/CALM1/DDIT3/SPPL3/AFG3L2/CD24/YWHAE/CALM2/CAV2/SRI/STC2/STOML2 28 GO:0000303 response to superoxide 3/969 28/18722 0.174669326889862 0.40732793499617 PRDX1/SOD3/BMP7 3 GO:0000423 mitophagy 3/969 28/18722 0.174669326889862 0.40732793499617 VPS13C/HUWE1/VDAC1 3 GO:0001945 lymph vessel development 3/969 28/18722 0.174669326889862 0.40732793499617 SVEP1/NR2F2/PTPN14 3 GO:0006516 glycoprotein catabolic process 3/969 28/18722 0.174669326889862 0.40732793499617 CTSL/MANBA/GPC1 3 GO:0006972 hyperosmotic response 3/969 28/18722 0.174669326889862 0.40732793499617 SLC2A1/AKR1B1/EFHD1 3 GO:0051503 adenine nucleotide transport 3/969 28/18722 0.174669326889862 0.40732793499617 GJA1/SLC25A6/SLC19A1 3 GO:0080111 DNA demethylation 3/969 28/18722 0.174669326889862 0.40732793499617 TET2/USP9X/GATA3 3 GO:1903020 positive regulation of glycoprotein metabolic process 3/969 28/18722 0.174669326889862 0.40732793499617 TCF7L2/PAWR/ARFGEF1 3 GO:1903779 regulation of cardiac conduction 3/969 28/18722 0.174669326889862 0.40732793499617 ATP2B1/ATP2B4/GJA5 3 GO:0038127 ERBB signaling pathway 9/969 121/18722 0.175138289185205 0.408057378190762 EGFR/IQGAP1/EFEMP1/GAB1/RPS6KA5/PTPN12/RBPJ/RTN4/ARF4 9 GO:0048706 embryonic skeletal system development 9/969 121/18722 0.175138289185205 0.408057378190762 PBX1/DLG1/NIPBL/SETD2/KIAA1217/GLI3/TFAP2A/MMP14/BMP7 9 GO:0045739 positive regulation of DNA repair 6/969 73/18722 0.176026089134847 0.409760508605217 EGFR/FUS/PRKDC/RPS3/RIF1/PARP1 6 GO:0050848 regulation of calcium-mediated signaling 6/969 73/18722 0.176026089134847 0.409760508605217 NFAT5/ATP2B4/SLC9A1/CALM1/SPPL3/CALM2 6 GO:0042129 regulation of T cell proliferation 12/969 171/18722 0.176360067529368 0.410355170484629 CD46/IGF2/DLG5/RPS3/ANXA1/IL6ST/DLG1/TFRC/LGALS3/PAWR/CD24/HES1 12 GO:0062207 regulation of pattern recognition receptor signaling pathway 8/969 105/18722 0.176826759269959 0.410905327854654 CAV1/LGR4/PUM1/HSPA1A/ANKRD17/PUM2/RTN4/HSPA1B 8 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 8/969 105/18722 0.176826759269959 0.410905327854654 PFN1/WASF2/NRP1/EPS8L1/ATMIN/PIK3R1/CDC42/EPS8 8 GO:0051781 positive regulation of cell division 7/969 89/18722 0.177365750943002 0.410905327854654 IGF2/PKN2/YBX1/RHOA/SVIL/CDC42/LBH 7 GO:0019693 ribose phosphate metabolic process 25/969 396/18722 0.177673080647496 0.410905327854654 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PYGL/PGAM1/STOML2/PGK1/IMPDH2/AK2 25 GO:0032946 positive regulation of mononuclear cell proliferation 10/969 138/18722 0.178217346322941 0.410905327854654 CD46/MIF/SLC39A10/IGF2/RPS3/ANXA1/IL6ST/TFRC/CD24/HES1 10 GO:0019439 aromatic compound catabolic process 29/969 467/18722 0.1783825805033 0.410905327854654 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/TET2/PUM1/TNRC6B/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/PDE4B/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HMOX1/HNRNPC/HNRNPU/SSB 29 GO:0051147 regulation of muscle cell differentiation 11/969 155/18722 0.180177372332924 0.410905327854654 IGF2/YBX1/MORF4L2/BHLHE41/ANKRD17/MMP14/DDX39B/YY1/MAPK14/XBP1/SUPT6H 11 GO:0018208 peptidyl-proline modification 5/969 58/18722 0.180225225422305 0.410905327854654 NKTR/PPIA/RANBP2/PPIG/P4HB 5 GO:0042743 hydrogen peroxide metabolic process 5/969 58/18722 0.180225225422305 0.410905327854654 EGFR/GPX3/PRDX6/PRDX1/GPX1 5 GO:0045604 regulation of epidermal cell differentiation 5/969 58/18722 0.180225225422305 0.410905327854654 ZFP36L1/ROCK1/NCOA3/SRSF6/HES1 5 GO:1902808 positive regulation of cell cycle G1/S phase transition 5/969 58/18722 0.180225225422305 0.410905327854654 EGFR/ADAMTS1/ANXA1/EIF4G1/ANKRD17 5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/969 15/18722 0.180435143172021 0.410905327854654 RPL7/RPL35 2 GO:0000722 telomere maintenance via recombination 2/969 15/18722 0.180435143172021 0.410905327854654 RAD50/TPRKB 2 GO:0002070 epithelial cell maturation 2/969 15/18722 0.180435143172021 0.410905327854654 AKR1B1/TFCP2L1 2 GO:0006098 pentose-phosphate shunt 2/969 15/18722 0.180435143172021 0.410905327854654 TALDO1/PGAM1 2 GO:0006268 DNA unwinding involved in DNA replication 2/969 15/18722 0.180435143172021 0.410905327854654 PURA/HMGA1 2 GO:0006704 glucocorticoid biosynthetic process 2/969 15/18722 0.180435143172021 0.410905327854654 CYP11A1/REST 2 GO:0010832 negative regulation of myotube differentiation 2/969 15/18722 0.180435143172021 0.410905327854654 BHLHE41/XBP1 2 GO:0014841 skeletal muscle satellite cell proliferation 2/969 15/18722 0.180435143172021 0.410905327854654 PAXBP1/CFLAR 2 GO:0014857 regulation of skeletal muscle cell proliferation 2/969 15/18722 0.180435143172021 0.410905327854654 PAXBP1/CFLAR 2 GO:0021542 dentate gyrus development 2/969 15/18722 0.180435143172021 0.410905327854654 CDK6/BTG2 2 GO:0032328 alanine transport 2/969 15/18722 0.180435143172021 0.410905327854654 SLC38A2/SLC3A2 2 GO:0032354 response to follicle-stimulating hormone 2/969 15/18722 0.180435143172021 0.410905327854654 TGFBR3/GCLM 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/969 15/18722 0.180435143172021 0.410905327854654 ISL1/LBH 2 GO:0042074 cell migration involved in gastrulation 2/969 15/18722 0.180435143172021 0.410905327854654 LRP5/AMOT 2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/969 15/18722 0.180435143172021 0.410905327854654 MIF/PTTG1IP 2 GO:0045064 T-helper 2 cell differentiation 2/969 15/18722 0.180435143172021 0.410905327854654 ANXA1/GATA3 2 GO:0045725 positive regulation of glycogen biosynthetic process 2/969 15/18722 0.180435143172021 0.410905327854654 IGF2/SORBS1 2 GO:0046184 aldehyde biosynthetic process 2/969 15/18722 0.180435143172021 0.410905327854654 TPI1/REST 2 GO:0050746 regulation of lipoprotein metabolic process 2/969 15/18722 0.180435143172021 0.410905327854654 ITGAV/RAB3GAP2 2 GO:0051127 positive regulation of actin nucleation 2/969 15/18722 0.180435143172021 0.410905327854654 WASF2/SCIN 2 GO:0051299 centrosome separation 2/969 15/18722 0.180435143172021 0.410905327854654 RANBP1/AURKA 2 GO:0055012 ventricular cardiac muscle cell differentiation 2/969 15/18722 0.180435143172021 0.410905327854654 CDK1/CCNB1 2 GO:0060253 negative regulation of glial cell proliferation 2/969 15/18722 0.180435143172021 0.410905327854654 DICER1/HES1 2 GO:0060413 atrial septum morphogenesis 2/969 15/18722 0.180435143172021 0.410905327854654 SOX4/ISL1 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/969 15/18722 0.180435143172021 0.410905327854654 NCOR1/FOXP1 2 GO:0070207 protein homotrimerization 2/969 15/18722 0.180435143172021 0.410905327854654 MIF/SLC1A5 2 GO:0070831 basement membrane assembly 2/969 15/18722 0.180435143172021 0.410905327854654 LAMB1/DAG1 2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 2/969 15/18722 0.180435143172021 0.410905327854654 SLC9A1/SPPL3 2 GO:0071599 otic vesicle development 2/969 15/18722 0.180435143172021 0.410905327854654 AHI1/GATA3 2 GO:0072044 collecting duct development 2/969 15/18722 0.180435143172021 0.410905327854654 DLG5/AKR1B1 2 GO:0072224 metanephric glomerulus development 2/969 15/18722 0.180435143172021 0.410905327854654 LGR4/EGR1 2 GO:0090594 inflammatory response to wounding 2/969 15/18722 0.180435143172021 0.410905327854654 GRN/HMOX1 2 GO:0097468 programmed cell death in response to reactive oxygen species 2/969 15/18722 0.180435143172021 0.410905327854654 MET/PAWR 2 GO:0099170 postsynaptic modulation of chemical synaptic transmission 2/969 15/18722 0.180435143172021 0.410905327854654 CDH1/USP8 2 GO:0106058 positive regulation of calcineurin-mediated signaling 2/969 15/18722 0.180435143172021 0.410905327854654 SLC9A1/SPPL3 2 GO:1905168 positive regulation of double-strand break repair via homologous recombination 2/969 15/18722 0.180435143172021 0.410905327854654 FUS/PARP1 2 GO:2000345 regulation of hepatocyte proliferation 2/969 15/18722 0.180435143172021 0.410905327854654 XBP1/CFLAR 2 GO:0070085 glycosylation 16/969 240/18722 0.18079661925637 0.410905327854654 TRIP11/EXTL2/GALNT11/TET2/GCNT2/C1GALT1/RPN2/FUT8/MAN2A1/OST4/MAN1A2/B4GALT5/B3GNT2/ARFGEF1/GALNT1/NANS 16 GO:0031109 microtubule polymerization or depolymerization 9/969 122/18722 0.181054531765868 0.410905327854654 AKAP9/CLIP1/MET/RPS3/HSPA1A/CAMSAP2/TAOK1/HSPA1B/STMN1 9 GO:0051208 sequestering of calcium ion 9/969 122/18722 0.181054531765868 0.410905327854654 HSP90B1/GSTO1/DIAPH1/MCOLN3/DMD/CALM1/DDIT3/CALM2/SRI 9 GO:0051928 positive regulation of calcium ion transport 9/969 122/18722 0.181054531765868 0.410905327854654 ATP2B1/CAV1/GSTO1/SLC9A1/LGALS3/CALM1/HOMER1/CALM2/SRI 9 GO:0021983 pituitary gland development 4/969 43/18722 0.181314138161659 0.410905327854654 CDH1/ISL1/RBPJ/HES1 4 GO:0030517 negative regulation of axon extension 4/969 43/18722 0.181314138161659 0.410905327854654 SEMA6A/SEMA6D/NRP1/RTN4 4 GO:0032365 intracellular lipid transport 4/969 43/18722 0.181314138161659 0.410905327854654 ANXA2/SYT7/ABCA1/NPC2 4 GO:0033173 calcineurin-NFAT signaling cascade 4/969 43/18722 0.181314138161659 0.410905327854654 NFAT5/ATP2B4/SLC9A1/SPPL3 4 GO:0035794 positive regulation of mitochondrial membrane permeability 4/969 43/18722 0.181314138161659 0.410905327854654 HSPA1A/SLC9A1/NMT1/VDAC2 4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4/969 43/18722 0.181314138161659 0.410905327854654 RPL26/MIF/EP300/TAF9 4 GO:0098927 vesicle-mediated transport between endosomal compartments 4/969 43/18722 0.181314138161659 0.410905327854654 EEA1/HOOK2/HOOK3/EZR 4 GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 4/969 43/18722 0.181314138161659 0.410905327854654 GSTP1/RHOA/GNA12/HMOX1 4 GO:0072503 cellular divalent inorganic cation homeostasis 30/969 486/18722 0.181956315785908 0.41218192730696 TPT1/ATP2B1/LRP1/CAV1/HSP90B1/ITGAV/APP/SLC39A10/GSTO1/GJA1/GTF2I/DIAPH1/S100A9/ATP2B4/ATP13A3/MCOLN3/TRPV6/CCDC47/DMD/CALM1/DDIT3/SPPL3/AFG3L2/CD24/YWHAE/CALM2/CAV2/SRI/STC2/STOML2 30 GO:0006766 vitamin metabolic process 8/969 106/18722 0.183243824764896 0.414738946826049 LRP2/GSTO1/SLC2A1/CYP11A1/MTR/SLC19A3/SLC52A3/SLC19A1 8 GO:0071887 leukocyte apoptotic process 8/969 106/18722 0.183243824764896 0.414738946826049 RPS6/SLC39A10/ANXA1/DOCK8/CTSL/GLI3/FOXP1/LGALS3 8 GO:0009201 ribonucleoside triphosphate biosynthetic process 6/969 74/18722 0.183810746432344 0.415482249504944 ALDOA/ENO1/TMSB4X/PARP1/STOML2/IMPDH2 6 GO:0051881 regulation of mitochondrial membrane potential 6/969 74/18722 0.183810746432344 0.415482249504944 SLC25A36/PARP1/PMAIP1/CLIC1/GCLM/STOML2 6 GO:0120192 tight junction assembly 6/969 74/18722 0.183810746432344 0.415482249504944 ACTG1/GJA1/DLG1/ROCK1/CLDN4/CLDN7 6 GO:0042593 glucose homeostasis 17/969 258/18722 0.183943023207846 0.415601486936533 LRP1/RPS6/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/PIK3R1/CCDC186/TCF7L2/XBP1/PYGL/HMGN3/GCLM/SRI 17 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 7/969 90/18722 0.184390298170702 0.416072408566533 CAV1/HECTD1/HSPA1A/DDA1/HSPA1B/CDC20/AURKA 7 GO:0048477 oogenesis 7/969 90/18722 0.184390298170702 0.416072408566533 RPS6/LGR5/DIAPH2/ZFX/YTHDC1/CCNB1/AURKA 7 GO:0097581 lamellipodium organization 7/969 90/18722 0.184390298170702 0.416072408566533 ITGB1/KANK1/WASF2/PIK3R1/VCL/RREB1/CDC42 7 GO:0042110 T cell activation 30/969 487/18722 0.184896299851515 0.417034123014251 CAV1/CD46/RPS6/ZFP36L1/IGF2/PRKDC/DLG5/RPL22/RPS3/SOX4/ANXA1/IL6ST/EGR1/DOCK8/DLG1/CTSL/GLI3/TFRC/RHOA/FOXP1/LGALS3/PAWR/EIF2AK4/XBP1/FLOT2/DPP4/GATA3/CD24/HES1/STOML2 30 GO:0006690 icosanoid metabolic process 9/969 123/18722 0.187059166425834 0.420395999680836 CYP2J2/MIF/ANXA1/GPX4/GSTP1/GPX1/PTGES3/AKR1B1/HPGD 9 GO:0030168 platelet activation 9/969 123/18722 0.187059166425834 0.420395999680836 ACTG1/HSPB1/IL6ST/PPIA/TLN1/MYL12A/CLIC1/VCL/MAPK14 9 GO:0051051 negative regulation of transport 29/969 470/18722 0.187354275458176 0.420395999680836 CAV1/ITGAV/C4orf3/GSTO1/LMAN1/GJA1/ANXA1/ANK3/GABRE/OAZ1/TPR/FRMD4A/PPP1R9A/FERMT1/TXN/LRPAP1/LGALS3/CALM1/WNK1/ATXN2/REST/GOPC/HMOX1/YWHAE/VDAC1/CALM2/VAMP3/YWHAQ/SRI 29 GO:0000305 response to oxygen radical 3/969 29/18722 0.187834798938912 0.420395999680836 PRDX1/SOD3/BMP7 3 GO:0001773 myeloid dendritic cell activation 3/969 29/18722 0.187834798938912 0.420395999680836 DHRS2/ITGB8/RBPJ 3 GO:0002360 T cell lineage commitment 3/969 29/18722 0.187834798938912 0.420395999680836 PRKDC/CTSL/RHOA 3 GO:0010390 histone monoubiquitination 3/969 29/18722 0.187834798938912 0.420395999680836 DDB1/SKP1/WAC 3 GO:0010458 exit from mitosis 3/969 29/18722 0.187834798938912 0.420395999680836 RPL24/UBE2C/EPS8 3 GO:0010592 positive regulation of lamellipodium assembly 3/969 29/18722 0.187834798938912 0.420395999680836 WASF2/PIK3R1/CDC42 3 GO:0015868 purine ribonucleotide transport 3/969 29/18722 0.187834798938912 0.420395999680836 GJA1/SLC25A6/SLC19A1 3 GO:0019082 viral protein processing 3/969 29/18722 0.187834798938912 0.420395999680836 FUT8/MAN2A1/GALNT1 3 GO:0030970 retrograde protein transport, ER to cytosol 3/969 29/18722 0.187834798938912 0.420395999680836 HSP90B1/SEL1L/FAF2 3 GO:0042759 long-chain fatty acid biosynthetic process 3/969 29/18722 0.187834798938912 0.420395999680836 GPX4/GSTP1/QKI 3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 3/969 29/18722 0.187834798938912 0.420395999680836 EGFR/CKS1B/CCNB1 3 GO:0048679 regulation of axon regeneration 3/969 29/18722 0.187834798938912 0.420395999680836 LRP1/GRN/PTPRF 3 GO:0060441 epithelial tube branching involved in lung morphogenesis 3/969 29/18722 0.187834798938912 0.420395999680836 DAG1/DLG5/KRAS 3 GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 3/969 29/18722 0.187834798938912 0.420395999680836 SEMA6A/CD63/ATP2B4 3 GO:1903513 endoplasmic reticulum to cytosol transport 3/969 29/18722 0.187834798938912 0.420395999680836 HSP90B1/SEL1L/FAF2 3 GO:0033500 carbohydrate homeostasis 17/969 259/18722 0.188034337274918 0.420662434331645 LRP1/RPS6/DYNLL1/SOX4/TRA2B/LRP5/IGF1R/PHPT1/KIF5B/PIK3R1/CCDC186/TCF7L2/XBP1/PYGL/HMGN3/GCLM/SRI 17 GO:0050863 regulation of T cell activation 21/969 329/18722 0.189041640290993 0.421928841364429 CAV1/CD46/IGF2/DLG5/RPS3/SOX4/ANXA1/IL6ST/DOCK8/DLG1/GLI3/TFRC/RHOA/LGALS3/PAWR/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 21 GO:0021885 forebrain cell migration 5/969 59/18722 0.18916557124318 0.421928841364429 LAMB1/ADGRG1/GLI3/RHOA/RTN4 5 GO:0032768 regulation of monooxygenase activity 5/969 59/18722 0.18916557124318 0.421928841364429 EGFR/CAV1/ATP2B4/CALM1/KRAS 5 GO:0043407 negative regulation of MAP kinase activity 5/969 59/18722 0.18916557124318 0.421928841364429 CAV1/DUSP1/GSTP1/NF1/BMP7 5 GO:0048010 vascular endothelial growth factor receptor signaling pathway 5/969 59/18722 0.18916557124318 0.421928841364429 HSPB1/NRP1/MAPK14/EPN2/PDCD6 5 GO:0051568 histone H3-K4 methylation 5/969 59/18722 0.18916557124318 0.421928841364429 ASH1L/KMT2C/TET2/RTF1/GATA3 5 GO:0071806 protein transmembrane transport 5/969 59/18722 0.18916557124318 0.421928841364429 HSPA5/SEC62/MCL1/ABCA1/DNAJC15 5 GO:0000018 regulation of DNA recombination 8/969 107/18722 0.189759936070903 0.422893571815155 FUS/RIF1/PARP1/SETD2/RAD50/TFRC/SUPT6H/KPNA2 8 GO:0008637 apoptotic mitochondrial changes 8/969 107/18722 0.189759936070903 0.422893571815155 JUN/GPX1/PMAIP1/HSPA1A/NMT1/GCLM/GHITM/VDAC2 8 GO:2000377 regulation of reactive oxygen species metabolic process 11/969 157/18722 0.190797965392749 0.425025646693311 EGFR/GSTP1/SLC5A3/RHOA/TFAP2A/BMP7/MAPK14/CFLAR/STK17A/VDAC1/ARF4 11 GO:1901215 negative regulation of neuron death 14/969 208/18722 0.191012805874411 0.425322932892915 LRP1/GRN/RASA1/ISL1/NRP1/EIF4G1/RHOA/TMEM259/BTG2/REST/GCLM/KRAS/HMOX1/PSMC1 14 GO:0045582 positive regulation of T cell differentiation 7/969 91/18722 0.191528003818061 0.425456601147424 CD46/SOX4/ANXA1/GLI3/RHOA/XBP1/GATA3 7 GO:0060191 regulation of lipase activity 7/969 91/18722 0.191528003818061 0.425456601147424 EGFR/LRP1/ANXA1/GNAQ/RHOA/ARF4/RHOC 7 GO:0006094 gluconeogenesis 6/969 75/18722 0.191728371478711 0.425456601147424 TPI1/DDB1/RANBP2/EP300/SLC35B4/PGK1 6 GO:2001259 positive regulation of cation channel activity 6/969 75/18722 0.191728371478711 0.425456601147424 GSTO1/ANK3/TMSB4X/KIF5B/CALM1/CALM2 6 GO:0008542 visual learning 4/969 44/18722 0.191886951569935 0.425456601147424 APP/ITGB1/NF1/KRAS 4 GO:0021517 ventral spinal cord development 4/969 44/18722 0.191886951569935 0.425456601147424 LMO4/SOX4/ISL1/GLI3 4 GO:0045124 regulation of bone resorption 4/969 44/18722 0.191886951569935 0.425456601147424 EGFR/NF1/TFRC/LTBP3 4 GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 4/969 44/18722 0.191886951569935 0.425456601147424 PRLR/CSH1/AKR1B1/HES1 4 GO:0060324 face development 4/969 44/18722 0.191886951569935 0.425456601147424 ANKRD11/NIPBL/EP300/ARID5B 4 GO:1903214 regulation of protein targeting to mitochondrion 4/969 44/18722 0.191886951569935 0.425456601147424 LMAN1/HUWE1/NPEPPS/UBE2L3 4 GO:0006486 protein glycosylation 15/969 226/18722 0.194744773672955 0.431426955156787 TRIP11/EXTL2/GALNT11/TET2/GCNT2/C1GALT1/RPN2/FUT8/MAN2A1/OST4/MAN1A2/B4GALT5/B3GNT2/ARFGEF1/GALNT1 15 GO:0043413 macromolecule glycosylation 15/969 226/18722 0.194744773672955 0.431426955156787 TRIP11/EXTL2/GALNT11/TET2/GCNT2/C1GALT1/RPN2/FUT8/MAN2A1/OST4/MAN1A2/B4GALT5/B3GNT2/ARFGEF1/GALNT1 15 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 14/969 209/18722 0.195689315371682 0.433335746666276 RPS3/SERPINB9/GPX1/PMAIP1/USP47/DHCR24/S100A9/RHOA/CTSD/CFLAR/SIAH2/PDCD6/REST/NDUFA13 14 GO:0050954 sensory perception of mechanical stimulus 12/969 175/18722 0.196534537284073 0.435023079985839 LRP2/GPX1/NIPBL/PGAP1/DIAPH1/TBL1X/TFAP2A/TRIOBP/SLC52A3/USP53/DDIT3/SERPINB6 12 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 5/969 60/18722 0.198260743178254 0.43502997327134 USP47/TAOK3/FOXN3/TAOK1/CDK1 5 GO:0002263 cell activation involved in immune response 18/969 279/18722 0.1987293720007 0.43502997327134 LRP1/CD46/RPS6/APP/GRN/ANXA1/RIF1/TFRC/FOXP1/LGALS3/EIF2AK4/XBP1/ITFG2/SUPT6H/VAMP2/GATA3/HMOX1/ANXA3 18 GO:0001708 cell fate specification 7/969 92/18722 0.198774981195151 0.43502997327134 ITGB1/LMO4/ISL1/NRP1/GLI3/TBX3/RBPJ 7 GO:0070585 protein localization to mitochondrion 9/969 125/18722 0.19932485109018 0.43502997327134 LMAN1/HUWE1/CALM1/NMT1/DDIT3/NPEPPS/UBE2L3/DNAJC15/NDUFA13 9 GO:0001977 renal system process involved in regulation of blood volume 2/969 16/18722 0.199534413687601 0.43502997327134 GJA1/GJA5 2 GO:0002693 positive regulation of cellular extravasation 2/969 16/18722 0.199534413687601 0.43502997327134 JAM3/CD99 2 GO:0006349 regulation of gene expression by genetic imprinting 2/969 16/18722 0.199534413687601 0.43502997327134 IGF2/DNMT3A 2 GO:0006740 NADPH regeneration 2/969 16/18722 0.199534413687601 0.43502997327134 TALDO1/PGAM1 2 GO:0006857 oligopeptide transport 2/969 16/18722 0.199534413687601 0.43502997327134 GJA1/SLC13A3 2 GO:0009299 mRNA transcription 2/969 16/18722 0.199534413687601 0.43502997327134 DDX5/SUPT6H 2 GO:0010225 response to UV-C 2/969 16/18722 0.199534413687601 0.43502997327134 MAP3K4/YY1 2 GO:0014819 regulation of skeletal muscle contraction 2/969 16/18722 0.199534413687601 0.43502997327134 GSTO1/DMD 2 GO:0021535 cell migration in hindbrain 2/969 16/18722 0.199534413687601 0.43502997327134 ITGB1/RERE 2 GO:0030033 microvillus assembly 2/969 16/18722 0.199534413687601 0.43502997327134 KLF5/EZR 2 GO:0030540 female genitalia development 2/969 16/18722 0.199534413687601 0.43502997327134 LRP2/TBX3 2 GO:0031268 pseudopodium organization 2/969 16/18722 0.199534413687601 0.43502997327134 CDC42/RAB25 2 GO:0034116 positive regulation of heterotypic cell-cell adhesion 2/969 16/18722 0.199534413687601 0.43502997327134 GCNT2/BMP7 2 GO:0034138 toll-like receptor 3 signaling pathway 2/969 16/18722 0.199534413687601 0.43502997327134 CAV1/COLEC12 2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 2/969 16/18722 0.199534413687601 0.43502997327134 TCERG1/HNRNPU 2 GO:0035751 regulation of lysosomal lumen pH 2/969 16/18722 0.199534413687601 0.43502997327134 GRN/ATP6AP2 2 GO:0043923 positive regulation by host of viral transcription 2/969 16/18722 0.199534413687601 0.43502997327134 JUN/EP300 2 GO:0045838 positive regulation of membrane potential 2/969 16/18722 0.199534413687601 0.43502997327134 ANK3/STOML2 2 GO:0046037 GMP metabolic process 2/969 16/18722 0.199534413687601 0.43502997327134 DLG1/IMPDH2 2 GO:0048557 embryonic digestive tract morphogenesis 2/969 16/18722 0.199534413687601 0.43502997327134 NIPBL/GLI3 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/969 16/18722 0.199534413687601 0.43502997327134 RPS3/KCNN4 2 GO:0050884 neuromuscular process controlling posture 2/969 16/18722 0.199534413687601 0.43502997327134 GAA/TMEM150C 2 GO:0061548 ganglion development 2/969 16/18722 0.199534413687601 0.43502997327134 NRP2/NRP1 2 GO:0070365 hepatocyte differentiation 2/969 16/18722 0.199534413687601 0.43502997327134 KRT18/ANXA1 2 GO:0071391 cellular response to estrogen stimulus 2/969 16/18722 0.199534413687601 0.43502997327134 SERPINB9/TRIM24 2 GO:0071732 cellular response to nitric oxide 2/969 16/18722 0.199534413687601 0.43502997327134 MTR/CFLAR 2 GO:0099633 protein localization to postsynaptic specialization membrane 2/969 16/18722 0.199534413687601 0.43502997327134 DAG1/DLG1 2 GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 2/969 16/18722 0.199534413687601 0.43502997327134 DAG1/DLG1 2 GO:1901163 regulation of trophoblast cell migration 2/969 16/18722 0.199534413687601 0.43502997327134 GJA1/AGO2 2 GO:1902570 protein localization to nucleolus 2/969 16/18722 0.199534413687601 0.43502997327134 NPM1/RAN 2 GO:2000001 regulation of DNA damage checkpoint 2/969 16/18722 0.199534413687601 0.43502997327134 PPP1R10/DDX39B 2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining 2/969 16/18722 0.199534413687601 0.43502997327134 PRKDC/RIF1 2 GO:0006305 DNA alkylation 6/969 76/18722 0.199773438934216 0.435187991609093 FOS/ATRX/PARP1/MPHOSPH8/DNMT3A/BAZ2A 6 GO:0006306 DNA methylation 6/969 76/18722 0.199773438934216 0.435187991609093 FOS/ATRX/PARP1/MPHOSPH8/DNMT3A/BAZ2A 6 GO:0009259 ribonucleotide metabolic process 24/969 385/18722 0.199986052469936 0.43530836817026 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0002685 regulation of leukocyte migration 14/969 210/18722 0.200418761457113 0.43530836817026 APP/MIF/ANXA1/DUSP1/DOCK8/MIA3/JAM3/CD99/RHOA/MMP14/LGALS3/WNK1/DPP4/HMOX1 14 GO:0097553 calcium ion transmembrane import into cytosol 10/969 142/18722 0.200974212772894 0.43530836817026 GSTO1/DIAPH1/ATP2B4/MCOLN3/TRPV6/DMD/CALM1/DDIT3/CALM2/SRI 10 GO:0000132 establishment of mitotic spindle orientation 3/969 30/18722 0.201244741197732 0.43530836817026 ITGB1/GJA1/DYNLT1 3 GO:0006099 tricarboxylic acid cycle 3/969 30/18722 0.201244741197732 0.43530836817026 IDH1/MDH2/SDHC 3 GO:0015865 purine nucleotide transport 3/969 30/18722 0.201244741197732 0.43530836817026 GJA1/SLC25A6/SLC19A1 3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 3/969 30/18722 0.201244741197732 0.43530836817026 CTSL/CTSD/CTSV 3 GO:0031365 N-terminal protein amino acid modification 3/969 30/18722 0.201244741197732 0.43530836817026 SOX4/NMT1/EP300 3 GO:0044788 modulation by host of viral process 3/969 30/18722 0.201244741197732 0.43530836817026 CFL1/EIF2AK4/CAV2 3 GO:0045577 regulation of B cell differentiation 3/969 30/18722 0.201244741197732 0.43530836817026 ZFP36L1/MMP14/XBP1 3 GO:0045948 positive regulation of translational initiation 3/969 30/18722 0.201244741197732 0.43530836817026 PPP1R15A/LARP1/EIF2AK4 3 GO:0048799 animal organ maturation 3/969 30/18722 0.201244741197732 0.43530836817026 RHOA/PLXNB1/GATA3 3 GO:0051491 positive regulation of filopodium assembly 3/969 30/18722 0.201244741197732 0.43530836817026 NRP1/PIK3R1/CDC42 3 GO:0060603 mammary gland duct morphogenesis 3/969 30/18722 0.201244741197732 0.43530836817026 LRP5/TBX3/KDM5B 3 GO:0061311 cell surface receptor signaling pathway involved in heart development 3/969 30/18722 0.201244741197732 0.43530836817026 GALNT11/JAG1/RBPJ 3 GO:0070229 negative regulation of lymphocyte apoptotic process 3/969 30/18722 0.201244741197732 0.43530836817026 SLC39A10/DOCK8/FOXP1 3 GO:0090151 establishment of protein localization to mitochondrial membrane 3/969 30/18722 0.201244741197732 0.43530836817026 CALM1/NMT1/NDUFA13 3 GO:0003009 skeletal muscle contraction 4/969 45/18722 0.202647171277527 0.437256035134746 GSTO1/GAA/DMD/HOMER1 4 GO:0003254 regulation of membrane depolarization 4/969 45/18722 0.202647171277527 0.437256035134746 ANK3/PARP1/GJA5/GCLM 4 GO:0006110 regulation of glycolytic process 4/969 45/18722 0.202647171277527 0.437256035134746 APP/NCOR1/EP300/PGAM1 4 GO:0030850 prostate gland development 4/969 45/18722 0.202647171277527 0.437256035134746 ANXA1/PSAP/GLI3/BMP7 4 GO:0031670 cellular response to nutrient 4/969 45/18722 0.202647171277527 0.437256035134746 ATP2B1/XBP1/TRIM24/HMOX1 4 GO:0060119 inner ear receptor cell development 4/969 45/18722 0.202647171277527 0.437256035134746 TRIP11/TRIOBP/NAGLU/HES1 4 GO:0032874 positive regulation of stress-activated MAPK cascade 9/969 126/18722 0.205581344501908 0.443404088471718 APP/GADD45B/MAP3K4/RB1CC1/TAOK3/TAOK1/CDC42/EMC10/PRMT1 9 GO:1902807 negative regulation of cell cycle G1/S phase transition 7/969 93/18722 0.206127240528968 0.44439808539785 RPL26/PRKDC/SOX4/DLG1/CTDSPL/BRD7/WAC 7 GO:0009100 glycoprotein metabolic process 24/969 387/18722 0.207009207423471 0.446115512575282 GANAB/TRIP11/EXTL2/GALNT11/TET2/CHPF/CTSL/MANBA/GCNT2/C1GALT1/RPN2/FUT8/MAN2A1/OST4/GNPTAB/TCF7L2/PAWR/AGO2/MAN1A2/GPC1/B4GALT5/B3GNT2/ARFGEF1/GALNT1 24 GO:0060402 calcium ion transport into cytosol 11/969 160/18722 0.207242779946832 0.446434776587858 CAV1/GSTO1/DIAPH1/ATP2B4/MCOLN3/TRPV6/DMD/CALM1/DDIT3/CALM2/SRI 11 GO:0043966 histone H3 acetylation 5/969 61/18722 0.20750219369498 0.446625397137549 ZNF451/EP300/PHF14/GATA3/TAF9 5 GO:2000401 regulation of lymphocyte migration 5/969 61/18722 0.20750219369498 0.446625397137549 APP/DOCK8/MIA3/RHOA/WNK1 5 GO:0002200 somatic diversification of immune receptors 6/969 77/18722 0.207940300621119 0.44738411323424 PRKDC/RIF1/TFRC/ADAR/YY1/SUPT6H 6 GO:1901361 organic cyclic compound catabolic process 30/969 495/18722 0.209306520115799 0.450138219804594 FUS/KCNQ1OT1/ZFP36L1/DDX5/ROCK1/NPM1/TET2/PUM1/TNRC6B/CYP19A1/HSPA1A/YBX1/DICER1/TNRC6A/UPF2/PDE4B/SMG1/CELF1/PUM2/LARP1/AGO2/MAPK14/BTG2/THRAP3/PABPC1/HSPA1B/HMOX1/HNRNPC/HNRNPU/SSB 30 GO:0061387 regulation of extent of cell growth 8/969 110/18722 0.209873520162706 0.451171952435337 LRP1/GOLGA4/SEMA6A/MACF1/SEMA6D/NRP1/RAB11A/RTN4 8 GO:0006109 regulation of carbohydrate metabolic process 12/969 178/18722 0.212317664249503 0.456238533457197 APP/IGF2/DDB1/CLTC/RANBP2/PMAIP1/NCOR1/SORBS1/EP300/SLC35B4/PGAM1/LCMT1 12 GO:0010830 regulation of myotube differentiation 4/969 46/18722 0.213580309713314 0.456879767536378 BHLHE41/MMP14/MAPK14/XBP1 4 GO:0031018 endocrine pancreas development 4/969 46/18722 0.213580309713314 0.456879767536378 SOX4/ANXA1/CDK6/HES1 4 GO:0031648 protein destabilization 4/969 46/18722 0.213580309713314 0.456879767536378 PRKDC/SIAH1/EP300/MYLIP 4 GO:0044818 mitotic G2/M transition checkpoint 4/969 46/18722 0.213580309713314 0.456879767536378 TAOK3/FOXN3/TAOK1/CDK1 4 GO:0061462 protein localization to lysosome 4/969 46/18722 0.213580309713314 0.456879767536378 GCC2/ZFYVE16/GNPTAB/RTN4 4 GO:1900271 regulation of long-term synaptic potentiation 4/969 46/18722 0.213580309713314 0.456879767536378 APP/PPP1R9A/EIF2AK4/MME 4 GO:0002042 cell migration involved in sprouting angiogenesis 7/969 94/18722 0.213580698032503 0.456879767536378 ITGB1/EPHB4/ANXA1/MIA3/NRP1/RHOA/HMOX1 7 GO:0048704 embryonic skeletal system morphogenesis 7/969 94/18722 0.213580698032503 0.456879767536378 DLG1/NIPBL/SETD2/GLI3/TFAP2A/MMP14/BMP7 7 GO:0001516 prostaglandin biosynthetic process 3/969 31/18722 0.214870010782878 0.456879767536378 MIF/ANXA1/PTGES3 3 GO:0030201 heparan sulfate proteoglycan metabolic process 3/969 31/18722 0.214870010782878 0.456879767536378 EXTL2/TCF7L2/GPC1 3 GO:0035115 embryonic forelimb morphogenesis 3/969 31/18722 0.214870010782878 0.456879767536378 NIPBL/TBX3/TFAP2A 3 GO:0035510 DNA dealkylation 3/969 31/18722 0.214870010782878 0.456879767536378 TET2/USP9X/GATA3 3 GO:0036474 cell death in response to hydrogen peroxide 3/969 31/18722 0.214870010782878 0.456879767536378 MET/TXN/PAWR 3 GO:0036475 neuron death in response to oxidative stress 3/969 31/18722 0.214870010782878 0.456879767536378 PARP1/MCL1/REST 3 GO:0046457 prostanoid biosynthetic process 3/969 31/18722 0.214870010782878 0.456879767536378 MIF/ANXA1/PTGES3 3 GO:0048384 retinoic acid receptor signaling pathway 3/969 31/18722 0.214870010782878 0.456879767536378 ESRRG/ACTN4/RXRA 3 GO:0060055 angiogenesis involved in wound healing 3/969 31/18722 0.214870010782878 0.456879767536378 DAG1/GPX1/XBP1 3 GO:0060390 regulation of SMAD protein signal transduction 3/969 31/18722 0.214870010782878 0.456879767536378 LRP1/PARP1/SPTBN1 3 GO:0071480 cellular response to gamma radiation 3/969 31/18722 0.214870010782878 0.456879767536378 RPL26/HSPA5/EGR1 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/969 31/18722 0.214870010782878 0.456879767536378 MIF/PTTG1IP/TAF9 3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/969 31/18722 0.214870010782878 0.456879767536378 GPX1/CFLAR/HMOX1 3 GO:1905144 response to acetylcholine 3/969 31/18722 0.214870010782878 0.456879767536378 LY6E/GNAQ/ATP2B4 3 GO:1905145 cellular response to acetylcholine 3/969 31/18722 0.214870010782878 0.456879767536378 LY6E/GNAQ/ATP2B4 3 GO:0032371 regulation of sterol transport 6/969 78/18722 0.21622320080495 0.456879767536378 LRP1/CAV1/ANXA2/ABCA1/NFKBIA/RXRA 6 GO:0032374 regulation of cholesterol transport 6/969 78/18722 0.21622320080495 0.456879767536378 LRP1/CAV1/ANXA2/ABCA1/NFKBIA/RXRA 6 GO:0071674 mononuclear cell migration 13/969 196/18722 0.21645629038596 0.456879767536378 APP/ANXA1/PLEC/DUSP1/DOCK8/MIA3/CD99/RHOA/LGALS3/WNK1/CDC42/EPS8/GATA3 13 GO:0001938 positive regulation of endothelial cell proliferation 8/969 111/18722 0.216756383492594 0.456879767536378 NRP2/IGF2/NRP1/RICTOR/PDCD6/EMC10/HMOX1/CAV2 8 GO:1902750 negative regulation of cell cycle G2/M phase transition 5/969 62/18722 0.216881265478488 0.456879767536378 USP47/TAOK3/FOXN3/TAOK1/CDK1 5 GO:0001936 regulation of endothelial cell proliferation 12/969 179/18722 0.217696084078018 0.456879767536378 NRP2/CAV1/IGF2/GJA1/NR2F2/NRP1/NF1/RICTOR/PDCD6/EMC10/HMOX1/CAV2 12 GO:0007626 locomotory behavior 12/969 179/18722 0.217696084078018 0.456879767536378 APP/GAA/ZFHX3/EGR1/PUM1/MCOLN3/NCOR1/VPS13A/NAGLU/DPP4/EPS8/CSTB 12 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 9/969 128/18722 0.218329753526241 0.456879767536378 APP/GADD45B/MAP3K4/RB1CC1/TAOK3/TAOK1/CDC42/EMC10/PRMT1 9 GO:0043524 negative regulation of neuron apoptotic process 10/969 145/18722 0.218813340077445 0.456879767536378 LRP1/GRN/RASA1/ISL1/NRP1/RHOA/BTG2/GCLM/KRAS/HMOX1 10 GO:0001829 trophectodermal cell differentiation 2/969 17/18722 0.21885381692654 0.456879767536378 JUNB/CITED2 2 GO:0003184 pulmonary valve morphogenesis 2/969 17/18722 0.21885381692654 0.456879767536378 JAG1/GJA5 2 GO:0006474 N-terminal protein amino acid acetylation 2/969 17/18722 0.21885381692654 0.456879767536378 SOX4/EP300 2 GO:0006895 Golgi to endosome transport 2/969 17/18722 0.21885381692654 0.456879767536378 VPS13C/VPS13A 2 GO:0007379 segment specification 2/969 17/18722 0.21885381692654 0.456879767536378 IRX2/MTF2 2 GO:0010224 response to UV-B 2/969 17/18722 0.21885381692654 0.456879767536378 MME/XPC 2 GO:0010566 regulation of ketone biosynthetic process 2/969 17/18722 0.21885381692654 0.456879767536378 EGR1/REST 2 GO:0010715 regulation of extracellular matrix disassembly 2/969 17/18722 0.21885381692654 0.456879767536378 LRP1/DPP4 2 GO:0010831 positive regulation of myotube differentiation 2/969 17/18722 0.21885381692654 0.456879767536378 MMP14/MAPK14 2 GO:0014856 skeletal muscle cell proliferation 2/969 17/18722 0.21885381692654 0.456879767536378 PAXBP1/CFLAR 2 GO:0015867 ATP transport 2/969 17/18722 0.21885381692654 0.456879767536378 GJA1/SLC25A6 2 GO:0021924 cell proliferation in external granule layer 2/969 17/18722 0.21885381692654 0.456879767536378 RERE/SLC6A4 2 GO:0021930 cerebellar granule cell precursor proliferation 2/969 17/18722 0.21885381692654 0.456879767536378 RERE/SLC6A4 2 GO:0031445 regulation of heterochromatin assembly 2/969 17/18722 0.21885381692654 0.456879767536378 TPR/MPHOSPH8 2 GO:0032048 cardiolipin metabolic process 2/969 17/18722 0.21885381692654 0.456879767536378 HADHA/STOML2 2 GO:0033151 V(D)J recombination 2/969 17/18722 0.21885381692654 0.456879767536378 PRKDC/YY1 2 GO:0033623 regulation of integrin activation 2/969 17/18722 0.21885381692654 0.456879767536378 JAM3/FERMT1 2 GO:0035518 histone H2A monoubiquitination 2/969 17/18722 0.21885381692654 0.456879767536378 DDB1/SKP1 2 GO:0035729 cellular response to hepatocyte growth factor stimulus 2/969 17/18722 0.21885381692654 0.456879767536378 NRP1/GCLM 2 GO:0035855 megakaryocyte development 2/969 17/18722 0.21885381692654 0.456879767536378 WASF2/EP300 2 GO:0042339 keratan sulfate metabolic process 2/969 17/18722 0.21885381692654 0.456879767536378 GNS/B3GNT2 2 GO:0042953 lipoprotein transport 2/969 17/18722 0.21885381692654 0.456879767536378 LRP1/MIA3 2 GO:0044539 long-chain fatty acid import into cell 2/969 17/18722 0.21885381692654 0.456879767536378 SLC2A1/SLC27A2 2 GO:0060033 anatomical structure regression 2/969 17/18722 0.21885381692654 0.456879767536378 LRP5/SMAD5 2 GO:0061298 retina vasculature development in camera-type eye 2/969 17/18722 0.21885381692654 0.456879767536378 LRP5/NRP1 2 GO:0070206 protein trimerization 2/969 17/18722 0.21885381692654 0.456879767536378 MIF/SLC1A5 2 GO:0070293 renal absorption 2/969 17/18722 0.21885381692654 0.456879767536378 CLDN4/MAGED2 2 GO:0070875 positive regulation of glycogen metabolic process 2/969 17/18722 0.21885381692654 0.456879767536378 IGF2/SORBS1 2 GO:0071816 tail-anchored membrane protein insertion into ER membrane 2/969 17/18722 0.21885381692654 0.456879767536378 EMC1/EMC10 2 GO:0097067 cellular response to thyroid hormone stimulus 2/969 17/18722 0.21885381692654 0.456879767536378 CTSL/GCLM 2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 2/969 17/18722 0.21885381692654 0.456879767536378 AKAP9/HOMER1 2 GO:0120261 regulation of heterochromatin organization 2/969 17/18722 0.21885381692654 0.456879767536378 TPR/MPHOSPH8 2 GO:0140354 lipid import into cell 2/969 17/18722 0.21885381692654 0.456879767536378 SLC2A1/SLC27A2 2 GO:1900034 regulation of cellular response to heat 2/969 17/18722 0.21885381692654 0.456879767536378 DNAJB1/EP300 2 GO:1901550 regulation of endothelial cell development 2/969 17/18722 0.21885381692654 0.456879767536378 ROCK1/VCL 2 GO:1902358 sulfate transmembrane transport 2/969 17/18722 0.21885381692654 0.456879767536378 SLC26A2/SLC13A4 2 GO:1903140 regulation of establishment of endothelial barrier 2/969 17/18722 0.21885381692654 0.456879767536378 ROCK1/VCL 2 GO:1903358 regulation of Golgi organization 2/969 17/18722 0.21885381692654 0.456879767536378 AKAP9/CAMSAP2 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/969 17/18722 0.21885381692654 0.456879767536378 GATA3/CD24 2 GO:0043410 positive regulation of MAPK cascade 29/969 480/18722 0.218910627231361 0.456879767536378 EGFR/LRP1/APP/MIF/GADD45B/IQGAP1/IGF2/RPS3/ROCK1/AKAP13/MAGED1/NRP1/PPIA/IGF1R/MAP3K4/GCNT2/RB1CC1/TAOK3/TAOK1/CFLAR/SPAG9/CDC42/EMC10/KRAS/CD24/TPBG/CAV2/TIMP2/PRMT1 29 GO:0042982 amyloid precursor protein metabolic process 7/969 95/18722 0.221131184924303 0.461145878856508 DLG1/ROCK1/DHCR24/PAWR/AGO2/RTN4/FLOT2 7 GO:0045666 positive regulation of neuron differentiation 7/969 95/18722 0.221131184924303 0.461145878856508 EIF4G1/RHOA/BMP7/SPAG9/REST/TIMP2/HMG20B 7 GO:0009141 nucleoside triphosphate metabolic process 8/969 112/18722 0.223723190598373 0.466207271758586 ALDOA/ENO1/TMSB4X/PARP1/RAN/RHOA/STOML2/IMPDH2 8 GO:0048562 embryonic organ morphogenesis 18/969 285/18722 0.223968027393622 0.466207271758586 FBN1/FBN2/DLG1/NIPBL/SETD2/GLI3/TBX3/EFEMP1/AHI1/TFAP2A/TRIOBP/MMP14/BMP7/NAGLU/CITED2/GATA3/HES1/MFAP5 18 GO:0006023 aminoglycan biosynthetic process 6/969 79/18722 0.224616291193371 0.466207271758586 CLTC/CHPF/GCNT2/B4GALT5/HEXA/B3GNT2 6 GO:0050772 positive regulation of axonogenesis 6/969 79/18722 0.224616291193371 0.466207271758586 LRP1/GOLGA4/MACF1/NRP1/RAB11A/PLXNB1 6 GO:0051279 regulation of release of sequestered calcium ion into cytosol 6/969 79/18722 0.224616291193371 0.466207271758586 GSTO1/DIAPH1/DMD/CALM1/CALM2/SRI 6 GO:0010761 fibroblast migration 4/969 47/18722 0.224671890354639 0.466207271758586 ITGB1/PLEC/GNA12/ARID5B 4 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 4/969 47/18722 0.224671890354639 0.466207271758586 GSTP1/HSPA1A/HSPA1B/CASP4 4 GO:0031641 regulation of myelination 4/969 47/18722 0.224671890354639 0.466207271758586 DAG1/CTSC/DLG1/DICER1 4 GO:0035850 epithelial cell differentiation involved in kidney development 4/969 47/18722 0.224671890354639 0.466207271758586 IQGAP1/JAG1/GATA3/CD24 4 GO:0045911 positive regulation of DNA recombination 4/969 47/18722 0.224671890354639 0.466207271758586 FUS/RIF1/PARP1/TFRC 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/969 47/18722 0.224671890354639 0.466207271758586 LGR4/RBPJ/DDIT3/ID1 4 GO:0006022 aminoglycan metabolic process 9/969 129/18722 0.224816737968119 0.466207271758586 ITIH5/CLTC/CHPF/GCNT2/GNS/B4GALT5/HEXA/NAGLU/B3GNT2 9 GO:0007498 mesoderm development 9/969 129/18722 0.224816737968119 0.466207271758586 ITGB4/ZFP36L1/ITGB1/WLS/GJA1/SETD2/TBX3/BMP7/CITED2 9 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/969 129/18722 0.224816737968119 0.466207271758586 RPS3/PMAIP1/S100A9/RHOA/CTSD/CFLAR/PDCD6/REST/NDUFA13 9 GO:0010675 regulation of cellular carbohydrate metabolic process 10/969 146/18722 0.224896389610294 0.466207271758586 IGF2/DDB1/RANBP2/PMAIP1/NCOR1/SORBS1/EP300/SLC35B4/PGAM1/LCMT1 10 GO:0008361 regulation of cell size 12/969 181/18722 0.228620716002 0.471255541589349 LRP1/GOLGA4/SEMA6A/MACF1/SEMA6D/NPM1/NRP1/KCNN4/RB1CC1/RAB11A/RHOA/RTN4 12 GO:0003180 aortic valve morphogenesis 3/969 32/18722 0.228682199583496 0.471255541589349 ROCK1/JAG1/GATA3 3 GO:0003338 metanephros morphogenesis 3/969 32/18722 0.228682199583496 0.471255541589349 LGR4/FRAS1/HES1 3 GO:0009954 proximal/distal pattern formation 3/969 32/18722 0.228682199583496 0.471255541589349 PBX1/GLI3/IRX2 3 GO:0010039 response to iron ion 3/969 32/18722 0.228682199583496 0.471255541589349 TFAP2A/HMOX1/CCNB1 3 GO:0010743 regulation of macrophage derived foam cell differentiation 3/969 32/18722 0.228682199583496 0.471255541589349 ITGAV/ABCA1/NFKBIA 3 GO:0045761 regulation of adenylate cyclase activity 3/969 32/18722 0.228682199583496 0.471255541589349 AKAP9/NF1/TIMP2 3 GO:0048841 regulation of axon extension involved in axon guidance 3/969 32/18722 0.228682199583496 0.471255541589349 SEMA6A/SEMA6D/NRP1 3 GO:0097345 mitochondrial outer membrane permeabilization 3/969 32/18722 0.228682199583496 0.471255541589349 HSPA1A/NMT1/VDAC2 3 GO:1901532 regulation of hematopoietic progenitor cell differentiation 3/969 32/18722 0.228682199583496 0.471255541589349 N4BP2L2/PRKDC/HES1 3 GO:1901889 negative regulation of cell junction assembly 3/969 32/18722 0.228682199583496 0.471255541589349 LRP1/ROCK1/MMP14 3 GO:1903955 positive regulation of protein targeting to mitochondrion 3/969 32/18722 0.228682199583496 0.471255541589349 HUWE1/NPEPPS/UBE2L3 3 GO:0030510 regulation of BMP signaling pathway 7/969 96/18722 0.228774456374317 0.471255541589349 FBN1/LRP2/CRIM1/TRIM33/RBPJ/HTRA1/HES1 7 GO:0042632 cholesterol homeostasis 7/969 96/18722 0.228774456374317 0.471255541589349 CAV1/LRP5/ABCA1/XBP1/MYLIP/CD24/NPC2 7 GO:1901655 cellular response to ketone 7/969 96/18722 0.228774456374317 0.471255541589349 EGFR/ATP2B1/NR3C1/AKR1B1/LARP1/CFLAR/USP8 7 GO:1904035 regulation of epithelial cell apoptotic process 7/969 96/18722 0.228774456374317 0.471255541589349 ZFP36L1/TIA1/TCF7L2/CFLAR/SRSF6/GATA3/HMOX1 7 GO:1902652 secondary alcohol metabolic process 10/969 147/18722 0.231044383021676 0.475743871422884 APP/CYP11A1/LRP5/DHCR24/ABCA1/MBTPS1/IDH1/NFE2L1/RXRA/NPC2 10 GO:0006352 DNA-templated transcription, initiation 9/969 130/18722 0.231375531119904 0.475863252905399 JUN/BDP1/BCLAF1/ZNF451/RSF1/SETX/BAZ2A/MED13/TAF9 9 GO:0015918 sterol transport 9/969 130/18722 0.231375531119904 0.475863252905399 LRP1/CAV1/ANXA2/SYT7/ABCA1/NFKBIA/RXRA/OSBPL9/NPC2 9 GO:0042476 odontogenesis 9/969 130/18722 0.231375531119904 0.475863252905399 CSF3R/LAMB1/LAMA5/ANKRD11/GLI3/RHOA/TFAP2A/BMP7/HTRA1 9 GO:0051303 establishment of chromosome localization 6/969 80/18722 0.23311364561472 0.479060917020262 DYNC1H1/RAB11A/EML4/KPNB1/HNRNPU/CCNB1 6 GO:1901264 carbohydrate derivative transport 6/969 80/18722 0.23311364561472 0.479060917020262 GJA1/PSAP/SLC25A6/SLC35B4/SLC19A1/NPC2 6 GO:0006111 regulation of gluconeogenesis 4/969 48/18722 0.235907498214465 0.480871695738578 DDB1/RANBP2/EP300/SLC35B4 4 GO:0010569 regulation of double-strand break repair via homologous recombination 4/969 48/18722 0.235907498214465 0.480871695738578 FUS/RIF1/PARP1/SETD2 4 GO:0015804 neutral amino acid transport 4/969 48/18722 0.235907498214465 0.480871695738578 SLC38A1/SLC38A2/SLC1A5/SLC3A2 4 GO:0030261 chromosome condensation 4/969 48/18722 0.235907498214465 0.480871695738578 BANF1/CDK1/NUSAP1/CCNB1 4 GO:0033628 regulation of cell adhesion mediated by integrin 4/969 48/18722 0.235907498214465 0.480871695738578 JAM3/FERMT1/WNK1/DPP4 4 GO:0097720 calcineurin-mediated signaling 4/969 48/18722 0.235907498214465 0.480871695738578 NFAT5/ATP2B4/SLC9A1/SPPL3 4 GO:1903053 regulation of extracellular matrix organization 4/969 48/18722 0.235907498214465 0.480871695738578 LRP1/DAG1/CFLAR/DPP4 4 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 4/969 48/18722 0.235907498214465 0.480871695738578 RPL11/EIF3H/WAC/TAF9 4 GO:0001885 endothelial cell development 5/969 64/18722 0.236017255813959 0.480871695738578 MET/ROCK1/GPX1/VCL/EZR 5 GO:0030104 water homeostasis 5/969 64/18722 0.236017255813959 0.480871695738578 MET/PLEC/CLDN4/AKR1B1/STMN1 5 GO:0098930 axonal transport 5/969 64/18722 0.236017255813959 0.480871695738578 ARMCX3/DYNC1H1/DST/HSPB1/KIF5B 5 GO:0043255 regulation of carbohydrate biosynthetic process 7/969 97/18722 0.236506200353302 0.480871695738578 IGF2/DDB1/CLTC/RANBP2/SORBS1/EP300/SLC35B4 7 GO:0055092 sterol homeostasis 7/969 97/18722 0.236506200353302 0.480871695738578 CAV1/LRP5/ABCA1/XBP1/MYLIP/CD24/NPC2 7 GO:0046651 lymphocyte proliferation 18/969 288/18722 0.23709413455694 0.480871695738578 CD46/RPS6/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DOCK8/DLG1/TFRC/PURA/LGALS3/PAWR/CD24/HES1/IMPDH2 18 GO:2000116 regulation of cysteine-type endopeptidase activity 15/969 235/18722 0.237184601237387 0.480871695738578 RPS3/SERPINB9/GPX1/PMAIP1/USP47/DHCR24/S100A9/RHOA/ASPH/CTSD/CFLAR/SIAH2/PDCD6/REST/NDUFA13 15 GO:2001056 positive regulation of cysteine-type endopeptidase activity 10/969 148/18722 0.237255219869721 0.480871695738578 RPS3/PMAIP1/S100A9/RHOA/ASPH/CTSD/CFLAR/PDCD6/REST/NDUFA13 10 GO:1903008 organelle disassembly 8/969 114/18722 0.237895650421301 0.480871695738578 UFL1/VPS13C/HUWE1/KIF5B/RB1CC1/CDK1/VDAC1/UFC1 8 GO:0001522 pseudouridine synthesis 2/969 18/18722 0.23831949712264 0.480871695738578 NHP2/NOP10 2 GO:0002076 osteoblast development 2/969 18/18722 0.23831949712264 0.480871695738578 JUND/LRP5 2 GO:0002544 chronic inflammatory response 2/969 18/18722 0.23831949712264 0.480871695738578 GJA1/S100A9 2 GO:0006337 nucleosome disassembly 2/969 18/18722 0.23831949712264 0.480871695738578 ARID1A/HMGA1 2 GO:0008272 sulfate transport 2/969 18/18722 0.23831949712264 0.480871695738578 SLC26A2/SLC13A4 2 GO:0010985 negative regulation of lipoprotein particle clearance 2/969 18/18722 0.23831949712264 0.480871695738578 LRPAP1/MYLIP 2 GO:0021534 cell proliferation in hindbrain 2/969 18/18722 0.23831949712264 0.480871695738578 RERE/SLC6A4 2 GO:0031643 positive regulation of myelination 2/969 18/18722 0.23831949712264 0.480871695738578 DAG1/DICER1 2 GO:0032769 negative regulation of monooxygenase activity 2/969 18/18722 0.23831949712264 0.480871695738578 CAV1/ATP2B4 2 GO:0032785 negative regulation of DNA-templated transcription, elongation 2/969 18/18722 0.23831949712264 0.480871695738578 TCERG1/HNRNPU 2 GO:0035372 protein localization to microtubule 2/969 18/18722 0.23831949712264 0.480871695738578 DIAPH1/HNRNPU 2 GO:0042693 muscle cell fate commitment 2/969 18/18722 0.23831949712264 0.480871695738578 TBX3/RBPJ 2 GO:0044872 lipoprotein localization 2/969 18/18722 0.23831949712264 0.480871695738578 LRP1/MIA3 2 GO:0045116 protein neddylation 2/969 18/18722 0.23831949712264 0.480871695738578 RPL11/EPAS1 2 GO:0051895 negative regulation of focal adhesion assembly 2/969 18/18722 0.23831949712264 0.480871695738578 LRP1/MMP14 2 GO:0060008 Sertoli cell differentiation 2/969 18/18722 0.23831949712264 0.480871695738578 ATRX/CTSV 2 GO:0071360 cellular response to exogenous dsRNA 2/969 18/18722 0.23831949712264 0.480871695738578 CAV1/COLEC12 2 GO:0071786 endoplasmic reticulum tubular network organization 2/969 18/18722 0.23831949712264 0.480871695738578 RAB3GAP2/RTN4 2 GO:0072079 nephron tubule formation 2/969 18/18722 0.23831949712264 0.480871695738578 IRX2/GATA3 2 GO:0072234 metanephric nephron tubule development 2/969 18/18722 0.23831949712264 0.480871695738578 LGR4/HES1 2 GO:0080182 histone H3-K4 trimethylation 2/969 18/18722 0.23831949712264 0.480871695738578 TET2/RTF1 2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 2/969 18/18722 0.23831949712264 0.480871695738578 LGR4/MAGED1 2 GO:0099558 maintenance of synapse structure 2/969 18/18722 0.23831949712264 0.480871695738578 DLG1/ERC1 2 GO:0150118 negative regulation of cell-substrate junction organization 2/969 18/18722 0.23831949712264 0.480871695738578 LRP1/MMP14 2 GO:1900006 positive regulation of dendrite development 2/969 18/18722 0.23831949712264 0.480871695738578 IQGAP1/BMP7 2 GO:1900242 regulation of synaptic vesicle endocytosis 2/969 18/18722 0.23831949712264 0.480871695738578 ROCK1/CALM1 2 GO:1900424 regulation of defense response to bacterium 2/969 18/18722 0.23831949712264 0.480871695738578 GRN/FOXP1 2 GO:1902074 response to salt 2/969 18/18722 0.23831949712264 0.480871695738578 HSPA5/HNRNPA1 2 GO:1902170 cellular response to reactive nitrogen species 2/969 18/18722 0.23831949712264 0.480871695738578 MTR/CFLAR 2 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 2/969 18/18722 0.23831949712264 0.480871695738578 SEMA6A/ATP2B4 2 GO:0006163 purine nucleotide metabolic process 24/969 396/18722 0.240035889270907 0.483976126128342 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0042445 hormone metabolic process 14/969 218/18722 0.240043268068248 0.483976126128342 ENPEP/CYP11A1/DHRS2/EGR1/CYP19A1/CTSL/TCF7L2/AKR1B1/PCSK7/MME/REST/ATP6AP2/GATA3/STC2 14 GO:0001942 hair follicle development 6/969 81/18722 0.241709274342112 0.486424373119011 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ 6 GO:1903533 regulation of protein targeting 6/969 81/18722 0.241709274342112 0.486424373119011 TCAF1/LMAN1/ANK3/HUWE1/NPEPPS/UBE2L3 6 GO:0003382 epithelial cell morphogenesis 3/969 33/18722 0.242653720000242 0.486424373119011 MET/FAT1/RAB25 3 GO:0010984 regulation of lipoprotein particle clearance 3/969 33/18722 0.242653720000242 0.486424373119011 ANXA2/LRPAP1/MYLIP 3 GO:0036336 dendritic cell migration 3/969 33/18722 0.242653720000242 0.486424373119011 DOCK8/CDC42/EPS8 3 GO:0042558 pteridine-containing compound metabolic process 3/969 33/18722 0.242653720000242 0.486424373119011 MTR/SLC19A1/GGH 3 GO:0045920 negative regulation of exocytosis 3/969 33/18722 0.242653720000242 0.486424373119011 ANXA1/REST/HMOX1 3 GO:0048333 mesodermal cell differentiation 3/969 33/18722 0.242653720000242 0.486424373119011 ITGB4/ITGB1/GJA1 3 GO:0060122 inner ear receptor cell stereocilium organization 3/969 33/18722 0.242653720000242 0.486424373119011 TRIP11/TRIOBP/HES1 3 GO:0070570 regulation of neuron projection regeneration 3/969 33/18722 0.242653720000242 0.486424373119011 LRP1/GRN/PTPRF 3 GO:1900181 negative regulation of protein localization to nucleus 3/969 33/18722 0.242653720000242 0.486424373119011 MAGED1/FERMT1/LATS2 3 GO:1901099 negative regulation of signal transduction in absence of ligand 3/969 33/18722 0.242653720000242 0.486424373119011 HSPA1A/MCL1/HSPA1B 3 GO:1902992 negative regulation of amyloid precursor protein catabolic process 3/969 33/18722 0.242653720000242 0.486424373119011 ROCK1/RTN4/FLOT2 3 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 3/969 33/18722 0.242653720000242 0.486424373119011 EGFR/CKS1B/CCNB1 3 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 3/969 33/18722 0.242653720000242 0.486424373119011 HSPA1A/MCL1/HSPA1B 3 GO:0032368 regulation of lipid transport 10/969 149/18722 0.243526760531722 0.487987289317016 LRP1/CAV1/ITGAV/ANXA2/CYP19A1/KDM5B/ABCA1/NFKBIA/RXRA/TMF1 10 GO:0003333 amino acid transmembrane transport 7/969 98/18722 0.244322046364588 0.489393259601892 ITGB1/SLC38A1/SLC38A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2 7 GO:0046916 cellular transition metal ion homeostasis 8/969 115/18722 0.245094673056721 0.490564826271323 FTH1/APP/SLC39A10/S100A9/TFRC/SLC40A1/HMOX1/SRI 8 GO:0051209 release of sequestered calcium ion into cytosol 8/969 115/18722 0.245094673056721 0.490564826271323 GSTO1/DIAPH1/MCOLN3/DMD/CALM1/DDIT3/CALM2/SRI 8 GO:0071677 positive regulation of mononuclear cell migration 5/969 65/18722 0.245756548641925 0.49151309728385 APP/DOCK8/RHOA/LGALS3/WNK1 5 GO:1902475 L-alpha-amino acid transmembrane transport 5/969 65/18722 0.245756548641925 0.49151309728385 ITGB1/SLC38A1/SLC1A5/SLC7A6/SLC3A2 5 GO:0009994 oocyte differentiation 4/969 49/18722 0.247272826383522 0.492284872640109 LGR5/ZFX/CCNB1/AURKA 4 GO:0014075 response to amine 4/969 49/18722 0.247272826383522 0.492284872640109 GLDC/RANBP2/CALM1/CDK1 4 GO:0021515 cell differentiation in spinal cord 4/969 49/18722 0.247272826383522 0.492284872640109 LMO4/SOX4/ISL1/GLI3 4 GO:0021695 cerebellar cortex development 4/969 49/18722 0.247272826383522 0.492284872640109 HSPA5/RERE/NAGLU/UQCRQ 4 GO:0043330 response to exogenous dsRNA 4/969 49/18722 0.247272826383522 0.492284872640109 CAV1/COLEC12/NFKBIA/SLC3A2 4 GO:0051932 synaptic transmission, GABAergic 4/969 49/18722 0.247272826383522 0.492284872640109 GABRE/KIF5B/KRAS/TPBG 4 GO:0052372 modulation by symbiont of entry into host 4/969 49/18722 0.247272826383522 0.492284872640109 CAV1/ITGAV/LY6E/P4HB 4 GO:0070169 positive regulation of biomineral tissue development 4/969 49/18722 0.247272826383522 0.492284872640109 FBN2/ATP2B1/TFAP2A/BMP7 4 GO:0086009 membrane repolarization 4/969 49/18722 0.247272826383522 0.492284872640109 AKAP9/CAV1/GJA5/YWHAE 4 GO:1901799 negative regulation of proteasomal protein catabolic process 4/969 49/18722 0.247272826383522 0.492284872640109 RPL11/EIF3H/WAC/TAF9 4 GO:1904894 positive regulation of receptor signaling pathway via STAT 4/969 49/18722 0.247272826383522 0.492284872640109 PRLR/CSH1/AKR1B1/HES1 4 GO:1990928 response to amino acid starvation 4/969 49/18722 0.247272826383522 0.492284872640109 SLC38A2/LARP1/EIF2AK4/ITFG2 4 GO:0051251 positive regulation of lymphocyte activation 22/969 362/18722 0.247740633687602 0.492752850135809 CAV1/CD46/MIF/SLC39A10/IGF2/PRKDC/RPS3/SOX4/ANXA1/IL6ST/DOCK8/RIF1/GLI3/TFRC/RHOA/MMP14/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 22 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 11/969 167/18722 0.247790755866227 0.492752850135809 CDH1/TENM3/ITGB1/DSC3/DSG2/CADM1/FAT1/PCDH11X/DSC2/CLSTN1/OBSL1 11 GO:0007254 JNK cascade 11/969 167/18722 0.247790755866227 0.492752850135809 EGFR/APP/GADD45B/GSTP1/IGF1R/RB1CC1/NCOR1/HACD3/TAOK3/TAOK1/CDC42 11 GO:0070665 positive regulation of leukocyte proliferation 10/969 150/18722 0.249856829012795 0.496672418570128 CD46/MIF/SLC39A10/IGF2/RPS3/ANXA1/IL6ST/TFRC/CD24/HES1 10 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 6/969 82/18722 0.250397138032555 0.497368089455771 GPX1/PMAIP1/PIK3R1/LGALS3/CFLAR/HMOX1 6 GO:0050000 chromosome localization 6/969 82/18722 0.250397138032555 0.497368089455771 DYNC1H1/RAB11A/EML4/KPNB1/HNRNPU/CCNB1 6 GO:0032943 mononuclear cell proliferation 18/969 291/18722 0.250533987106946 0.497450842181193 CD46/RPS6/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DOCK8/DLG1/TFRC/PURA/LGALS3/PAWR/CD24/HES1/IMPDH2 18 GO:0002040 sprouting angiogenesis 12/969 185/18722 0.251100261976112 0.498385859888781 SEMA6A/ITGB1/PKM/EPHB4/ANXA1/MIA3/NRP1/RNF213/RHOA/EPN2/CDC42/HMOX1 12 GO:0010717 regulation of epithelial to mesenchymal transition 7/969 99/18722 0.252217574038458 0.500413455552385 DAG1/ISL1/GCNT2/JAG1/TCF7L2/BMP7/GATA3 7 GO:0051283 negative regulation of sequestering of calcium ion 8/969 116/18722 0.252364390667891 0.500514726994459 GSTO1/DIAPH1/MCOLN3/DMD/CALM1/DDIT3/CALM2/SRI 8 GO:0099173 postsynapse organization 11/969 168/18722 0.253806992218692 0.503184879110351 NRP2/ACTG1/CFL1/WASF2/DLG1/NRP1/IGF1R/PPP1R9A/HOMER1/CDC42/ARF4 11 GO:0060326 cell chemotaxis 19/969 310/18722 0.255543121583606 0.503775927622171 CSF3R/MIF/MET/ANXA1/PLEC/HSPB1/DUSP1/GSTP1/NRP1/PPIA/TMSB4X/JAM3/S100A9/GAB1/PDE4B/LGALS3/WNK1/DPP4/TPBG 19 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 5/969 66/18722 0.255598259721524 0.503775927622171 PRKDC/RIF1/TFRC/YY1/SUPT6H 5 GO:0016444 somatic cell DNA recombination 5/969 66/18722 0.255598259721524 0.503775927622171 PRKDC/RIF1/TFRC/YY1/SUPT6H 5 GO:0046626 regulation of insulin receptor signaling pathway 5/969 66/18722 0.255598259721524 0.503775927622171 KANK1/IGF2/PIK3R1/SORBS1/PTPRE 5 GO:0050918 positive chemotaxis 5/969 66/18722 0.255598259721524 0.503775927622171 LRP1/MIF/MET/NRP1/LGALS3 5 GO:2000573 positive regulation of DNA biosynthetic process 5/969 66/18722 0.255598259721524 0.503775927622171 MAP3K4/PTGES3/HNRNPA1/DDX39B/CCT8 5 GO:0007018 microtubule-based movement 23/969 382/18722 0.255689931018645 0.503775927622171 ARMCX3/APP/DYNC1H1/DST/ASH1L/HSPB1/KTN1/DYNLRB1/ARHGAP21/KIF5B/ATP2B4/PURA/PCM1/VPS13A/RAB6A/KPNB1/FLOT2/TMF1/CDC42/SFPQ/HNRNPU/DYNLT1/UXT 23 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 3/969 34/18722 0.256757875557361 0.503775927622171 CTSL/CTSD/CTSV 3 GO:0010614 negative regulation of cardiac muscle hypertrophy 3/969 34/18722 0.256757875557361 0.503775927622171 ATP2B4/JARID2/YY1 3 GO:0019076 viral release from host cell 3/969 34/18722 0.256757875557361 0.503775927622171 DDB1/PPIA/CAV2 3 GO:0019320 hexose catabolic process 3/969 34/18722 0.256757875557361 0.503775927622171 ENO1/LRP5/FUT8 3 GO:0032212 positive regulation of telomere maintenance via telomerase 3/969 34/18722 0.256757875557361 0.503775927622171 MAP3K4/HNRNPA1/CCT8 3 GO:0034383 low-density lipoprotein particle clearance 3/969 34/18722 0.256757875557361 0.503775927622171 ANXA2/MYLIP/HMOX1 3 GO:0035890 exit from host 3/969 34/18722 0.256757875557361 0.503775927622171 DDB1/PPIA/CAV2 3 GO:0035891 exit from host cell 3/969 34/18722 0.256757875557361 0.503775927622171 DDB1/PPIA/CAV2 3 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 3/969 34/18722 0.256757875557361 0.503775927622171 PUM1/ANKRD17/PUM2 3 GO:0043276 anoikis 3/969 34/18722 0.256757875557361 0.503775927622171 CAV1/ITGB1/MCL1 3 GO:0048261 negative regulation of receptor-mediated endocytosis 3/969 34/18722 0.256757875557361 0.503775927622171 ITGAV/LRPAP1/ATXN2 3 GO:0055094 response to lipoprotein particle 3/969 34/18722 0.256757875557361 0.503775927622171 ITGB1/MIA3/ABCA1 3 GO:0008217 regulation of blood pressure 12/969 186/18722 0.256842599885395 0.503775927622171 ATP2B1/GJA1/ENPEP/NR2F2/LRP5/ADRB1/RHOA/WNK1/GJA5/MME/ATP6AP2/HMOX1 12 GO:0002523 leukocyte migration involved in inflammatory response 2/969 19/18722 0.257864639569328 0.503775927622171 JAM3/S100A9 2 GO:0002902 regulation of B cell apoptotic process 2/969 19/18722 0.257864639569328 0.503775927622171 SLC39A10/FOXP1 2 GO:0006007 glucose catabolic process 2/969 19/18722 0.257864639569328 0.503775927622171 ENO1/LRP5 2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/969 19/18722 0.257864639569328 0.503775927622171 RPL26/SOX4 2 GO:0007603 phototransduction, visible light 2/969 19/18722 0.257864639569328 0.503775927622171 GNAQ/NMT1 2 GO:0030220 platelet formation 2/969 19/18722 0.257864639569328 0.503775927622171 PRKDC/EP300 2 GO:0033194 response to hydroperoxide 2/969 19/18722 0.257864639569328 0.503775927622171 GPX3/GPX1 2 GO:0035313 wound healing, spreading of epidermal cells 2/969 19/18722 0.257864639569328 0.503775927622171 FERMT1/RREB1 2 GO:0036344 platelet morphogenesis 2/969 19/18722 0.257864639569328 0.503775927622171 PRKDC/EP300 2 GO:0051444 negative regulation of ubiquitin-protein transferase activity 2/969 19/18722 0.257864639569328 0.503775927622171 RPL11/RPS20 2 GO:0060039 pericardium development 2/969 19/18722 0.257864639569328 0.503775927622171 SETD2/BMP7 2 GO:0086014 atrial cardiac muscle cell action potential 2/969 19/18722 0.257864639569328 0.503775927622171 GJA1/GJA5 2 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 2/969 19/18722 0.257864639569328 0.503775927622171 GJA1/GJA5 2 GO:0086066 atrial cardiac muscle cell to AV node cell communication 2/969 19/18722 0.257864639569328 0.503775927622171 GJA1/GJA5 2 GO:0098780 response to mitochondrial depolarisation 2/969 19/18722 0.257864639569328 0.503775927622171 VPS13C/HUWE1 2 GO:1901739 regulation of myoblast fusion 2/969 19/18722 0.257864639569328 0.503775927622171 MAPK14/CFLAR 2 GO:1903978 regulation of microglial cell activation 2/969 19/18722 0.257864639569328 0.503775927622171 GRN/CTSC 2 GO:2000251 positive regulation of actin cytoskeleton reorganization 2/969 19/18722 0.257864639569328 0.503775927622171 NRP1/CDC42 2 GO:2000738 positive regulation of stem cell differentiation 2/969 19/18722 0.257864639569328 0.503775927622171 LTBP3/TACSTD2 2 GO:0000387 spliceosomal snRNP assembly 4/969 50/18722 0.258753718731769 0.504193487730136 SNRPD2/SNRPG/SNRPD1/SNRPC 4 GO:0001961 positive regulation of cytokine-mediated signaling pathway 4/969 50/18722 0.258753718731769 0.504193487730136 TRIM44/HSPA1A/HSPA1B/CASP4 4 GO:0019083 viral transcription 4/969 50/18722 0.258753718731769 0.504193487730136 JUN/RSF1/EP300/REST 4 GO:0030490 maturation of SSU-rRNA 4/969 50/18722 0.258753718731769 0.504193487730136 RPS21/RPS8/RPS16/SNU13 4 GO:0045058 T cell selection 4/969 50/18722 0.258753718731769 0.504193487730136 CTSL/GLI3/RHOA/GATA3 4 GO:0070231 T cell apoptotic process 4/969 50/18722 0.258753718731769 0.504193487730136 RPS6/DOCK8/GLI3/LGALS3 4 GO:0110151 positive regulation of biomineralization 4/969 50/18722 0.258753718731769 0.504193487730136 FBN2/ATP2B1/TFAP2A/BMP7 4 GO:0051899 membrane depolarization 6/969 83/18722 0.259171161254079 0.504818668920542 JUN/CAV1/ANK3/PARP1/GJA5/GCLM 6 GO:0030301 cholesterol transport 8/969 117/18722 0.259701376468513 0.505474634422514 LRP1/CAV1/ANXA2/SYT7/ABCA1/NFKBIA/RXRA/NPC2 8 GO:0072676 lymphocyte migration 8/969 117/18722 0.259701376468513 0.505474634422514 APP/PLEC/DOCK8/MIA3/CD99/RHOA/WNK1/GATA3 8 GO:0002687 positive regulation of leukocyte migration 9/969 135/18722 0.265154299621601 0.51567388158891 APP/DOCK8/MIA3/JAM3/CD99/RHOA/MMP14/LGALS3/WNK1 9 GO:0006513 protein monoubiquitination 5/969 67/18722 0.265533565892797 0.51567388158891 DDB1/SKP1/HUWE1/WAC/PDCD6 5 GO:0006879 cellular iron ion homeostasis 5/969 67/18722 0.265533565892797 0.51567388158891 FTH1/TFRC/SLC40A1/HMOX1/SRI 5 GO:0010517 regulation of phospholipase activity 5/969 67/18722 0.265533565892797 0.51567388158891 EGFR/LRP1/ANXA1/GNAQ/ARF4 5 GO:0016445 somatic diversification of immunoglobulins 5/969 67/18722 0.265533565892797 0.51567388158891 PRKDC/RIF1/TFRC/YY1/SUPT6H 5 GO:0043967 histone H4 acetylation 5/969 67/18722 0.265533565892797 0.51567388158891 MORF4L2/USP22/EP300/PHF20/IWS1 5 GO:0050920 regulation of chemotaxis 14/969 223/18722 0.266261592899111 0.516895648027769 SEMA6A/MIF/MET/MYCBP2/SEMA6D/HSPB1/DUSP1/GSTP1/NRP1/TMSB4X/JAM3/WNK1/DPP4/TPBG 14 GO:0030203 glycosaminoglycan metabolic process 8/969 118/18722 0.26710216900402 0.518142514927621 ITIH5/CLTC/CHPF/GCNT2/GNS/HEXA/NAGLU/B3GNT2 8 GO:0051282 regulation of sequestering of calcium ion 8/969 118/18722 0.26710216900402 0.518142514927621 GSTO1/DIAPH1/MCOLN3/DMD/CALM1/DDIT3/CALM2/SRI 8 GO:0002088 lens development in camera-type eye 6/969 84/18722 0.268025245577192 0.519162317785917 DLG1/CRYBG3/FAT1/KDM5B/CITED2/GATA3 6 GO:0022404 molting cycle process 6/969 84/18722 0.268025245577192 0.519162317785917 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ 6 GO:0022405 hair cycle process 6/969 84/18722 0.268025245577192 0.519162317785917 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ 6 GO:0098586 cellular response to virus 6/969 84/18722 0.268025245577192 0.519162317785917 PUM1/ANKRD17/PUM2/ADAR/EIF5A/MAPK14 6 GO:0048839 inner ear development 12/969 188/18722 0.268463180592995 0.519817925816596 LGR5/TRIP11/GLI3/AHI1/MCOLN3/TFAP2A/TRIOBP/JAG1/RBPJ/NAGLU/GATA3/HES1 12 GO:0007338 single fertilization 10/969 153/18722 0.269175954881309 0.521005014892489 ALDOA/CD46/ASH1L/KDM5B/SPESP1/CDK1/SNU13/VDAC2/LY6K/CCT8 10 GO:0010656 negative regulation of muscle cell apoptotic process 4/969 51/18722 0.27033620888715 0.521769920841695 PPP1R10/BMP7/CFLAR/HMOX1 4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4/969 51/18722 0.27033620888715 0.521769920841695 ASH1L/GSTP1/RHOA/USP10 4 GO:0051339 regulation of lyase activity 4/969 51/18722 0.27033620888715 0.521769920841695 AKAP9/PHPT1/NF1/TIMP2 4 GO:0003298 physiological muscle hypertrophy 3/969 35/18722 0.270968917941898 0.521769920841695 AKAP13/DDX39B/YY1 3 GO:0003301 physiological cardiac muscle hypertrophy 3/969 35/18722 0.270968917941898 0.521769920841695 AKAP13/DDX39B/YY1 3 GO:0006739 NADP metabolic process 3/969 35/18722 0.270968917941898 0.521769920841695 IDH1/TALDO1/PGAM1 3 GO:0007020 microtubule nucleation 3/969 35/18722 0.270968917941898 0.521769920841695 AKAP9/HSPA1A/HSPA1B 3 GO:0010664 negative regulation of striated muscle cell apoptotic process 3/969 35/18722 0.270968917941898 0.521769920841695 PPP1R10/BMP7/CFLAR 3 GO:0015695 organic cation transport 3/969 35/18722 0.270968917941898 0.521769920841695 SLC38A2/ATP13A3/SLC19A3 3 GO:0018149 peptide cross-linking 3/969 35/18722 0.270968917941898 0.521769920841695 DSP/ANXA1/KRT10 3 GO:0021955 central nervous system neuron axonogenesis 3/969 35/18722 0.270968917941898 0.521769920841695 MYCBP2/NFIB/B4GALT5 3 GO:0031076 embryonic camera-type eye development 3/969 35/18722 0.270968917941898 0.521769920841695 TFAP2A/BMP7/CITED2 3 GO:0061049 cell growth involved in cardiac muscle cell development 3/969 35/18722 0.270968917941898 0.521769920841695 AKAP13/DDX39B/YY1 3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 3/969 35/18722 0.270968917941898 0.521769920841695 ANXA1/NRP1/HMOX1 3 GO:0050727 regulation of inflammatory response 23/969 386/18722 0.27183637934749 0.523247483782682 NEAT1/EGFR/APP/GRN/BRD4/ANXA1/ASH1L/GPX4/IL6ST/CTSC/ISL1/GSTP1/TMSB4X/GPX1/UFL1/S100A9/RICTOR/CELF1/FOXP1/MAPK14/NFKBIA/GATA3/CASP4 23 GO:0010906 regulation of glucose metabolic process 8/969 119/18722 0.274563277609487 0.527599579645268 IGF2/DDB1/RANBP2/PMAIP1/SORBS1/EP300/SLC35B4/LCMT1 8 GO:0007585 respiratory gaseous exchange by respiratory system 5/969 68/18722 0.275553679313082 0.527599579645268 GAA/SLC5A3/FUT8/MAN2A1/MAN1A2 5 GO:0034394 protein localization to cell surface 5/969 68/18722 0.275553679313082 0.527599579645268 JAM3/RAB11A/VCL/TM9SF4/GOPC 5 GO:0042267 natural killer cell mediated cytotoxicity 5/969 68/18722 0.275553679313082 0.527599579645268 SERPINB9/PRDX1/CADM1/KIF5B/TUBB4B 5 GO:0042698 ovulation cycle 5/969 68/18722 0.275553679313082 0.527599579645268 EGFR/HSPA5/ADAMTS1/EGR1/NRIP1 5 GO:0046686 response to cadmium ion 5/969 68/18722 0.275553679313082 0.527599579645268 JUN/EGFR/FOS/CDK1/HMOX1 5 GO:0010522 regulation of calcium ion transport into cytosol 7/969 102/18722 0.276337471233764 0.527599579645268 CAV1/GSTO1/DIAPH1/DMD/CALM1/CALM2/SRI 7 GO:0009142 nucleoside triphosphate biosynthetic process 6/969 85/18722 0.276953282210208 0.527599579645268 ALDOA/ENO1/TMSB4X/PARP1/STOML2/IMPDH2 6 GO:0055072 iron ion homeostasis 6/969 85/18722 0.276953282210208 0.527599579645268 FTH1/TFRC/EPAS1/SLC40A1/HMOX1/SRI 6 GO:0098773 skin epidermis development 6/969 85/18722 0.276953282210208 0.527599579645268 EGFR/LAMA5/LGR5/LGR4/FERMT1/RBPJ 6 GO:2000779 regulation of double-strand break repair 6/969 85/18722 0.276953282210208 0.527599579645268 FUS/PRKDC/RIF1/PARP1/SETD2/UBR5 6 GO:0050670 regulation of lymphocyte proliferation 14/969 225/18722 0.277021396102397 0.527599579645268 CD46/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DLG1/TFRC/LGALS3/PAWR/CD24/HES1 14 GO:0006346 DNA methylation-dependent heterochromatin assembly 2/969 20/18722 0.277428940846766 0.527599579645268 MPHOSPH8/DNMT3A 2 GO:0010042 response to manganese ion 2/969 20/18722 0.277428940846766 0.527599579645268 APP/HSPA5 2 GO:0016553 base conversion or substitution editing 2/969 20/18722 0.277428940846766 0.527599579645268 RBM47/ADAR 2 GO:0031498 chromatin disassembly 2/969 20/18722 0.277428940846766 0.527599579645268 ARID1A/HMGA1 2 GO:0032930 positive regulation of superoxide anion generation 2/969 20/18722 0.277428940846766 0.527599579645268 EGFR/GSTP1 2 GO:0032986 protein-DNA complex disassembly 2/969 20/18722 0.277428940846766 0.527599579645268 ARID1A/HMGA1 2 GO:0042359 vitamin D metabolic process 2/969 20/18722 0.277428940846766 0.527599579645268 LRP2/CYP11A1 2 GO:0043586 tongue development 2/969 20/18722 0.277428940846766 0.527599579645268 EGFR/GLI3 2 GO:0043651 linoleic acid metabolic process 2/969 20/18722 0.277428940846766 0.527599579645268 CYP2J2/GSTP1 2 GO:0046931 pore complex assembly 2/969 20/18722 0.277428940846766 0.527599579645268 RTN4/CCT8 2 GO:0051900 regulation of mitochondrial depolarization 2/969 20/18722 0.277428940846766 0.527599579645268 PARP1/GCLM 2 GO:0060252 positive regulation of glial cell proliferation 2/969 20/18722 0.277428940846766 0.527599579645268 EGFR/UFL1 2 GO:0071397 cellular response to cholesterol 2/969 20/18722 0.277428940846766 0.527599579645268 DAG1/ABCA1 2 GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/969 20/18722 0.277428940846766 0.527599579645268 LRP1/FOXP1 2 GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/969 20/18722 0.277428940846766 0.527599579645268 GPX1/GHITM 2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/969 20/18722 0.277428940846766 0.527599579645268 HSPA1A/XBP1 2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 2/969 20/18722 0.277428940846766 0.527599579645268 MET/TXN 2 GO:1903817 negative regulation of voltage-gated potassium channel activity 2/969 20/18722 0.277428940846766 0.527599579645268 CAV1/ANK3 2 GO:1904263 positive regulation of TORC1 signaling 2/969 20/18722 0.277428940846766 0.527599579645268 WAC/SEC13 2 GO:1904292 regulation of ERAD pathway 2/969 20/18722 0.277428940846766 0.527599579645268 CAV1/TMEM259 2 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/969 20/18722 0.277428940846766 0.527599579645268 LRP1/FOXP1 2 GO:1902105 regulation of leukocyte differentiation 17/969 279/18722 0.278321257240159 0.529103997940004 FBN1/JUN/FOS/CD46/ZFP36L1/PRKDC/SOX4/ANXA1/CDK6/GLI3/PIK3R1/RHOA/FOXP1/MMP14/ESRRA/XBP1/GATA3 17 GO:0008203 cholesterol metabolic process 9/969 137/18722 0.279074549859289 0.530150344443709 APP/CYP11A1/LRP5/DHCR24/ABCA1/MBTPS1/NFE2L1/RXRA/NPC2 9 GO:0010977 negative regulation of neuron projection development 9/969 137/18722 0.279074549859289 0.530150344443709 LRP1/SEMA6A/KANK1/SEMA6D/NRP1/RHOA/THOC2/RTN4/MYLIP 9 GO:0009566 fertilization 12/969 190/18722 0.280254121027491 0.532197687677931 ALDOA/CD46/NR2F2/ASH1L/KDM5B/SPESP1/ZFX/CDK1/SNU13/VDAC2/LY6K/CCT8 12 GO:0035176 social behavior 4/969 52/18722 0.282006555620554 0.53462968258854 PCM1/VPS13A/CHD8/SLC6A4 4 GO:0045010 actin nucleation 4/969 52/18722 0.282006555620554 0.53462968258854 IQGAP2/WASF2/ARPC3/SCIN 4 GO:2000378 negative regulation of reactive oxygen species metabolic process 4/969 52/18722 0.282006555620554 0.53462968258854 RHOA/TFAP2A/CFLAR/VDAC1 4 GO:0002761 regulation of myeloid leukocyte differentiation 8/969 120/18722 0.282081187779553 0.53462968258854 FBN1/JUN/FOS/ZFP36L1/CDK6/PIK3R1/FOXP1/ESRRA 8 GO:0071901 negative regulation of protein serine/threonine kinase activity 8/969 120/18722 0.282081187779553 0.53462968258854 CAV1/NR2F2/DUSP1/GSTP1/LRP5/NF1/LATS2/BMP7 8 GO:0062012 regulation of small molecule metabolic process 20/969 334/18722 0.282148615495445 0.53462968258854 CAV1/APP/IGF2/ENO1/ANXA1/DDB1/EGR1/TMSB4X/PARP1/RANBP2/PMAIP1/ATP2B4/NCOR1/SORBS1/MBTPS1/EP300/SLC35B4/REST/PGAM1/LCMT1 20 GO:0030593 neutrophil chemotaxis 7/969 103/18722 0.284506816028142 0.538576478407116 CSF3R/PPIA/JAM3/S100A9/PDE4B/LGALS3/DPP4 7 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 3/969 36/18722 0.285262091892632 0.538576478407116 CTSL/CTSD/CTSV 3 GO:0014741 negative regulation of muscle hypertrophy 3/969 36/18722 0.285262091892632 0.538576478407116 ATP2B4/JARID2/YY1 3 GO:0045191 regulation of isotype switching 3/969 36/18722 0.285262091892632 0.538576478407116 RIF1/TFRC/SUPT6H 3 GO:0045652 regulation of megakaryocyte differentiation 3/969 36/18722 0.285262091892632 0.538576478407116 SCIN/RCOR1/PRMT1 3 GO:0045738 negative regulation of DNA repair 3/969 36/18722 0.285262091892632 0.538576478407116 RPS3/RIF1/UBR5 3 GO:0045746 negative regulation of Notch signaling pathway 3/969 36/18722 0.285262091892632 0.538576478407116 MMP14/BMP7/NFKBIA 3 GO:0070897 transcription preinitiation complex assembly 3/969 36/18722 0.285262091892632 0.538576478407116 BDP1/BAZ2A/TAF9 3 GO:0071402 cellular response to lipoprotein particle stimulus 3/969 36/18722 0.285262091892632 0.538576478407116 ITGB1/MIA3/ABCA1 3 GO:0090322 regulation of superoxide metabolic process 3/969 36/18722 0.285262091892632 0.538576478407116 EGFR/GSTP1/BMP7 3 GO:0060193 positive regulation of lipase activity 5/969 69/18722 0.285649867492836 0.539113834423099 EGFR/GNAQ/RHOA/ARF4/RHOC 5 GO:0006493 protein O-linked glycosylation 6/969 86/18722 0.285949164161041 0.539289185097654 GALNT11/TET2/C1GALT1/B4GALT5/B3GNT2/GALNT1 6 GO:0022406 membrane docking 6/969 86/18722 0.285949164161041 0.539289185097654 ROCK1/CALM1/AHCYL1/EZR/CAV2/VAMP3 6 GO:0055076 transition metal ion homeostasis 9/969 138/18722 0.28611109894322 0.539399928960054 FTH1/APP/SLC39A10/S100A9/TFRC/EPAS1/SLC40A1/HMOX1/SRI 9 GO:0009101 glycoprotein biosynthetic process 19/969 317/18722 0.287254733156098 0.541360705183472 TRIP11/EXTL2/GALNT11/TET2/CHPF/GCNT2/C1GALT1/RPN2/FUT8/MAN2A1/OST4/TCF7L2/PAWR/AGO2/MAN1A2/B4GALT5/B3GNT2/ARFGEF1/GALNT1 19 GO:0032944 regulation of mononuclear cell proliferation 14/969 227/18722 0.287922071711193 0.54242276379333 CD46/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DLG1/TFRC/LGALS3/PAWR/CD24/HES1 14 GO:0070663 regulation of leukocyte proliferation 15/969 245/18722 0.288235680544487 0.542817897847023 CD46/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DLG1/GSTP1/TFRC/LGALS3/PAWR/CD24/HES1 15 GO:0001764 neuron migration 10/969 156/18722 0.288940593264776 0.543949402162003 NRP2/SEMA6A/ADGRG1/NR2F2/NRP1/NIPBL/USP9X/PCM1/ZNF609/GATA3 10 GO:0002696 positive regulation of leukocyte activation 24/969 409/18722 0.291386564701612 0.548356567205843 CAV1/CD46/JUND/MIF/SLC39A10/IGF2/PRKDC/RPS3/SOX4/ANXA1/IL6ST/CTSC/DOCK8/RIF1/GLI3/TFRC/RHOA/MMP14/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 24 GO:0070661 leukocyte proliferation 19/969 318/18722 0.291891908882004 0.549109832907615 CD46/RPS6/MIF/SLC39A10/IGF2/DLG5/RPS3/ANXA1/IL6ST/DOCK8/DLG1/GSTP1/TFRC/PURA/LGALS3/PAWR/CD24/HES1/IMPDH2 19 GO:0016925 protein sumoylation 4/969 53/18722 0.293751274774469 0.552011564894418 EGR1/RANBP2/ZNF451/HMG20B 4 GO:0034381 plasma lipoprotein particle clearance 4/969 53/18722 0.293751274774469 0.552011564894418 ANXA2/LRPAP1/MYLIP/HMOX1 4 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 4/969 53/18722 0.293751274774469 0.552011564894418 MET/ATP2B4/PDE4B/STMN1 4 GO:0019915 lipid storage 6/969 87/18722 0.295006797910976 0.554053234082173 CAV1/ITGAV/PLIN2/ABCA1/NRIP1/NFKBIA 6 GO:0070830 bicellular tight junction assembly 5/969 70/18722 0.295813472124061 0.554053234082173 GJA1/DLG1/ROCK1/CLDN4/CLDN7 5 GO:0000002 mitochondrial genome maintenance 2/969 21/18722 0.296958114937651 0.554053234082173 SLC25A36/PARP1 2 GO:0006450 regulation of translational fidelity 2/969 21/18722 0.296958114937651 0.554053234082173 RPS5/IARS2 2 GO:0006925 inflammatory cell apoptotic process 2/969 21/18722 0.296958114937651 0.554053234082173 ANXA1/CTSL 2 GO:0007063 regulation of sister chromatid cohesion 2/969 21/18722 0.296958114937651 0.554053234082173 ATRX/SFPQ 2 GO:0010988 regulation of low-density lipoprotein particle clearance 2/969 21/18722 0.296958114937651 0.554053234082173 ANXA2/MYLIP 2 GO:0034035 purine ribonucleoside bisphosphate metabolic process 2/969 21/18722 0.296958114937651 0.554053234082173 SLC26A2/TPST2 2 GO:0035020 regulation of Rac protein signal transduction 2/969 21/18722 0.296958114937651 0.554053234082173 KRAS/DYNLT1 2 GO:0048745 smooth muscle tissue development 2/969 21/18722 0.296958114937651 0.554053234082173 DLG1/NF1 2 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 2/969 21/18722 0.296958114937651 0.554053234082173 SLC26A2/TPST2 2 GO:0060972 left/right pattern formation 2/969 21/18722 0.296958114937651 0.554053234082173 AHI1/CITED2 2 GO:0072170 metanephric tubule development 2/969 21/18722 0.296958114937651 0.554053234082173 LGR4/HES1 2 GO:0072243 metanephric nephron epithelium development 2/969 21/18722 0.296958114937651 0.554053234082173 LGR4/HES1 2 GO:0097062 dendritic spine maintenance 2/969 21/18722 0.296958114937651 0.554053234082173 IGF1R/HOMER1 2 GO:0099515 actin filament-based transport 2/969 21/18722 0.296958114937651 0.554053234082173 SYNE2/ACTN4 2 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2/969 21/18722 0.296958114937651 0.554053234082173 HSPA1A/NMT1 2 GO:1902259 regulation of delayed rectifier potassium channel activity 2/969 21/18722 0.296958114937651 0.554053234082173 ANK3/VAMP2 2 GO:1902473 regulation of protein localization to synapse 2/969 21/18722 0.296958114937651 0.554053234082173 DAG1/DLG1 2 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 2/969 21/18722 0.296958114937651 0.554053234082173 RHOA/CFLAR 2 GO:1990266 neutrophil migration 8/969 122/18722 0.297273267120064 0.554443288354551 CSF3R/PPIA/JAM3/S100A9/PDE4B/CD99/LGALS3/DPP4 8 GO:0071356 cellular response to tumor necrosis factor 14/969 229/18722 0.298953411642141 0.557019222856048 KRT8/KRT18/ZFP36L1/RPS3/GSTP1/TMSB4X/HSPA1A/EIF5A/MAPK14/ACTN4/NFKBIA/HSPA1B/GATA3/CASP4 14 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3/969 37/18722 0.299613669240021 0.557019222856048 UPF2/SMG1/PABPC1 3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3/969 37/18722 0.299613669240021 0.557019222856048 RPS21/RPS8/RPS16 3 GO:0032885 regulation of polysaccharide biosynthetic process 3/969 37/18722 0.299613669240021 0.557019222856048 IGF2/CLTC/SORBS1 3 GO:0034260 negative regulation of GTPase activity 3/969 37/18722 0.299613669240021 0.557019222856048 AMOT/WNK1/ARFGEF1 3 GO:0045730 respiratory burst 3/969 37/18722 0.299613669240021 0.557019222856048 GRN/CD24/PGAM1 3 GO:0051294 establishment of spindle orientation 3/969 37/18722 0.299613669240021 0.557019222856048 ITGB1/GJA1/DYNLT1 3 GO:0060416 response to growth hormone 3/969 37/18722 0.299613669240021 0.557019222856048 CSH1/PIK3R1/CACYBP 3 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 3/969 37/18722 0.299613669240021 0.557019222856048 MAP3K4/HNRNPA1/CCT8 3 GO:0002285 lymphocyte activation involved in immune response 12/969 194/18722 0.304293708242629 0.565518819088185 CD46/RPS6/ANXA1/RIF1/TFRC/FOXP1/LGALS3/EIF2AK4/XBP1/ITFG2/SUPT6H/GATA3 12 GO:0006584 catecholamine metabolic process 4/969 54/18722 0.305557167879346 0.567060283855634 LY6E/EPAS1/AKR1B1/GATA3 4 GO:0009712 catechol-containing compound metabolic process 4/969 54/18722 0.305557167879346 0.567060283855634 LY6E/EPAS1/AKR1B1/GATA3 4 GO:0051703 biological process involved in intraspecies interaction between organisms 4/969 54/18722 0.305557167879346 0.567060283855634 PCM1/VPS13A/CHD8/SLC6A4 4 GO:0070228 regulation of lymphocyte apoptotic process 4/969 54/18722 0.305557167879346 0.567060283855634 SLC39A10/DOCK8/FOXP1/LGALS3 4 GO:0002228 natural killer cell mediated immunity 5/969 71/18722 0.306035926707043 0.567545689485808 SERPINB9/PRDX1/CADM1/KIF5B/TUBB4B 5 GO:0050795 regulation of behavior 5/969 71/18722 0.306035926707043 0.567545689485808 GJA1/ZFHX3/ADRB1/AHI1/EIF2AK4 5 GO:0071466 cellular response to xenobiotic stimulus 11/969 177/18722 0.309993936733708 0.574681913221128 EGFR/CYP2J2/HSPA5/GSTO1/GSTP1/TFRC/PDE4B/ABCA1/PPP1R12A/REST/GSTA3 11 GO:0043583 ear development 13/969 213/18722 0.310396617785184 0.575224370406159 LGR5/TRIP11/NIPBL/GLI3/AHI1/MCOLN3/TFAP2A/TRIOBP/JAG1/RBPJ/NAGLU/GATA3/HES1 13 GO:0010508 positive regulation of autophagy 8/969 124/18722 0.31265001182621 0.57919495278404 ROCK1/UFL1/LARP1/WAC/RAB3GAP2/UVRAG/HMOX1/VDAC1 8 GO:0046330 positive regulation of JNK cascade 6/969 89/18722 0.313283080635364 0.579415268690811 APP/GADD45B/RB1CC1/TAOK3/TAOK1/CDC42 6 GO:0002478 antigen processing and presentation of exogenous peptide antigen 3/969 38/18722 0.314000973286323 0.579415268690811 CTSL/CTSD/CTSV 3 GO:0007007 inner mitochondrial membrane organization 3/969 38/18722 0.314000973286323 0.579415268690811 AFG3L2/GHITM/NDUFA13 3 GO:0032717 negative regulation of interleukin-8 production 3/969 38/18722 0.314000973286323 0.579415268690811 ANXA1/TMSB4X/ANXA4 3 GO:0046329 negative regulation of JNK cascade 3/969 38/18722 0.314000973286323 0.579415268690811 GSTP1/NCOR1/TAOK3 3 GO:0048713 regulation of oligodendrocyte differentiation 3/969 38/18722 0.314000973286323 0.579415268690811 DAG1/NF1/HES1 3 GO:0098926 postsynaptic signal transduction 3/969 38/18722 0.314000973286323 0.579415268690811 LY6E/GNAQ/KPNA2 3 GO:0099622 cardiac muscle cell membrane repolarization 3/969 38/18722 0.314000973286323 0.579415268690811 AKAP9/GJA5/YWHAE 3 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 3/969 38/18722 0.314000973286323 0.579415268690811 HSPA1A/NMT1/VDAC2 3 GO:1903580 positive regulation of ATP metabolic process 3/969 38/18722 0.314000973286323 0.579415268690811 APP/ENO1/TMSB4X 3 GO:0007009 plasma membrane organization 9/969 142/18722 0.314700243586765 0.579415268690811 CAV1/PLEC/ANK3/S100A9/SYT7/SPTBN1/SPESP1/MYOF/CAV2 9 GO:0001707 mesoderm formation 5/969 72/18722 0.316308772986226 0.579415268690811 ITGB4/ITGB1/WLS/GJA1/BMP7 5 GO:0030032 lamellipodium assembly 5/969 72/18722 0.316308772986226 0.579415268690811 ITGB1/WASF2/PIK3R1/VCL/CDC42 5 GO:0051057 positive regulation of small GTPase mediated signal transduction 5/969 72/18722 0.316308772986226 0.579415268690811 ITGAV/ADGRG1/AKAP13/KRAS/DYNLT1 5 GO:0006379 mRNA cleavage 2/969 22/18722 0.316403432941723 0.579415268690811 PCF11/AGO2 2 GO:0006907 pinocytosis 2/969 22/18722 0.316403432941723 0.579415268690811 CAV1/CDC42 2 GO:0007398 ectoderm development 2/969 22/18722 0.316403432941723 0.579415268690811 TPT1/ITGA6 2 GO:0007413 axonal fasciculation 2/969 22/18722 0.316403432941723 0.579415268690811 NRP1/RTN4 2 GO:0008211 glucocorticoid metabolic process 2/969 22/18722 0.316403432941723 0.579415268690811 CYP11A1/REST 2 GO:0014821 phasic smooth muscle contraction 2/969 22/18722 0.316403432941723 0.579415268690811 DLG1/TBX3 2 GO:0019400 alditol metabolic process 2/969 22/18722 0.316403432941723 0.579415268690811 TPI1/AKR1B1 2 GO:0032402 melanosome transport 2/969 22/18722 0.316403432941723 0.579415268690811 RAB11A/RAB17 2 GO:0045061 thymic T cell selection 2/969 22/18722 0.316403432941723 0.579415268690811 GLI3/GATA3 2 GO:0045663 positive regulation of myoblast differentiation 2/969 22/18722 0.316403432941723 0.579415268690811 BTG1/MAPK14 2 GO:0046628 positive regulation of insulin receptor signaling pathway 2/969 22/18722 0.316403432941723 0.579415268690811 IGF2/SORBS1 2 GO:0060563 neuroepithelial cell differentiation 2/969 22/18722 0.316403432941723 0.579415268690811 SOX4/HES1 2 GO:0071404 cellular response to low-density lipoprotein particle stimulus 2/969 22/18722 0.316403432941723 0.579415268690811 ITGB1/ABCA1 2 GO:0072574 hepatocyte proliferation 2/969 22/18722 0.316403432941723 0.579415268690811 XBP1/CFLAR 2 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 2/969 22/18722 0.316403432941723 0.579415268690811 XBP1/CFLAR 2 GO:0106030 neuron projection fasciculation 2/969 22/18722 0.316403432941723 0.579415268690811 NRP1/RTN4 2 GO:1900543 negative regulation of purine nucleotide metabolic process 2/969 22/18722 0.316403432941723 0.579415268690811 PARP1/NCOR1 2 GO:1901032 negative regulation of response to reactive oxygen species 2/969 22/18722 0.316403432941723 0.579415268690811 MET/TXN 2 GO:0035725 sodium ion transmembrane transport 11/969 178/18722 0.316427703184764 0.579415268690811 UTRN/ANK3/DLG1/KIF5B/ATP2B4/SLC9A1/DMD/WNK1/SLC6A4/ACTN4/SLC3A2 11 GO:0010676 positive regulation of cellular carbohydrate metabolic process 4/969 55/18722 0.317411347606346 0.58033980249548 IGF2/DDB1/PMAIP1/SORBS1 4 GO:0048016 inositol phosphate-mediated signaling 4/969 55/18722 0.317411347606346 0.58033980249548 NFAT5/ATP2B4/SLC9A1/SPPL3 4 GO:0051898 negative regulation of protein kinase B signaling 4/969 55/18722 0.317411347606346 0.58033980249548 DAG1/DLG1/DDIT3/PDCD6 4 GO:0032526 response to retinoic acid 7/969 107/18722 0.317709945453419 0.58033980249548 GJA1/DUSP1/ABCA1/SLC6A4/SETX/RXRA/NDUFA13 7 GO:0042303 molting cycle 7/969 107/18722 0.317709945453419 0.58033980249548 EGFR/LAMA5/LGR5/LGR4/NIPBL/FERMT1/RBPJ 7 GO:0042633 hair cycle 7/969 107/18722 0.317709945453419 0.58033980249548 EGFR/LAMA5/LGR5/LGR4/NIPBL/FERMT1/RBPJ 7 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 7/969 107/18722 0.317709945453419 0.58033980249548 CAV1/HECTD1/HSPA1A/DDA1/HSPA1B/CDC20/AURKA 7 GO:0002683 negative regulation of immune system process 25/969 434/18722 0.318639075489412 0.581833615830772 FBN1/CD46/MIF/GRN/PRKDC/DLG5/ANXA1/SERPINB9/CDK6/DUSP1/DLG1/MIA3/GPX1/PHPT1/GLI3/PIK3R1/LGALS3/ADAR/PAWR/MAPK14/PCBP2/HTRA1/DPP4/EZR/HMOX1 25 GO:0071621 granulocyte chemotaxis 8/969 125/18722 0.320398740765426 0.584836088694731 CSF3R/ANXA1/PPIA/JAM3/S100A9/PDE4B/LGALS3/DPP4 8 GO:0072521 purine-containing compound metabolic process 24/969 416/18722 0.32050718676267 0.584836088694731 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0042475 odontogenesis of dentin-containing tooth 6/969 90/18722 0.322489707954268 0.588042991545361 CSF3R/LAMA5/ANKRD11/GLI3/BMP7/HTRA1 6 GO:0045638 negative regulation of myeloid cell differentiation 6/969 90/18722 0.322489707954268 0.588042991545361 FBN1/ZFP36L1/CDK6/PIK3R1/NFKBIA/PRMT1 6 GO:0007416 synapse assembly 11/969 179/18722 0.32289227348342 0.588366464862048 CDH1/APP/DLG5/PPP1R9A/EIF4G1/PLXNB1/SETD5/CLSTN1/OBSL1/TPBG/RAB17 11 GO:0010950 positive regulation of endopeptidase activity 11/969 179/18722 0.32289227348342 0.588366464862048 RPS3/PMAIP1/S100A9/RHOA/ASPH/CTSD/CFLAR/PSME2/PDCD6/REST/NDUFA13 11 GO:0007173 epidermal growth factor receptor signaling pathway 7/969 108/18722 0.326119489874589 0.594039893372117 EGFR/IQGAP1/EFEMP1/GAB1/RPS6KA5/PTPN12/ARF4 7 GO:0002637 regulation of immunoglobulin production 5/969 73/18722 0.326623676210592 0.594336814720249 PRKDC/RIF1/TFRC/XBP1/SUPT6H 5 GO:0061035 regulation of cartilage development 5/969 73/18722 0.326623676210592 0.594336814720249 GLG1/GLI3/EFEMP1/SCIN/LTBP3 5 GO:1904427 positive regulation of calcium ion transmembrane transport 5/969 73/18722 0.326623676210592 0.594336814720249 GSTO1/SLC9A1/CALM1/CALM2/SRI 5 GO:0010463 mesenchymal cell proliferation 3/969 39/18722 0.328402394611625 0.596327628297552 LRP5/NFIB/BMP7 3 GO:0016233 telomere capping 3/969 39/18722 0.328402394611625 0.596327628297552 PRKDC/MAP3K4/RAD50 3 GO:0017158 regulation of calcium ion-dependent exocytosis 3/969 39/18722 0.328402394611625 0.596327628297552 SYT7/TRPV6/REST 3 GO:0032506 cytokinetic process 3/969 39/18722 0.328402394611625 0.596327628297552 PLEC/RHOA/SNX18 3 GO:0034314 Arp2/3 complex-mediated actin nucleation 3/969 39/18722 0.328402394611625 0.596327628297552 IQGAP2/WASF2/ARPC3 3 GO:0046326 positive regulation of glucose import 3/969 39/18722 0.328402394611625 0.596327628297552 PIK3R1/SORBS1/MAPK14 3 GO:0002090 regulation of receptor internalization 4/969 56/18722 0.329301260208185 0.596922783852923 CD63/AHI1/LRPAP1/ATXN2 4 GO:0042733 embryonic digit morphogenesis 4/969 56/18722 0.329301260208185 0.596922783852923 LRP5/GLI3/TBX3/TMEM107 4 GO:0043470 regulation of carbohydrate catabolic process 4/969 56/18722 0.329301260208185 0.596922783852923 APP/NCOR1/EP300/PGAM1 4 GO:0045599 negative regulation of fat cell differentiation 4/969 56/18722 0.329301260208185 0.596922783852923 JAG1/ANKRD26/DDIT3/GATA3 4 GO:0048008 platelet-derived growth factor receptor signaling pathway 4/969 56/18722 0.329301260208185 0.596922783852923 LRP1/NRP1/PTPN12/ARID5B 4 GO:0001919 regulation of receptor recycling 2/969 23/18722 0.335721294239551 0.602913911922988 ANXA2/VAMP3 2 GO:0002082 regulation of oxidative phosphorylation 2/969 23/18722 0.335721294239551 0.602913911922988 RHOA/DNAJC15 2 GO:0002363 alpha-beta T cell lineage commitment 2/969 23/18722 0.335721294239551 0.602913911922988 CTSL/RHOA 2 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 2/969 23/18722 0.335721294239551 0.602913911922988 LRP1/PTPN12 2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 2/969 23/18722 0.335721294239551 0.602913911922988 CLDN4/CLDN7 2 GO:0032401 establishment of melanosome localization 2/969 23/18722 0.335721294239551 0.602913911922988 RAB11A/RAB17 2 GO:0035162 embryonic hemopoiesis 2/969 23/18722 0.335721294239551 0.602913911922988 PBX1/GATA3 2 GO:0035988 chondrocyte proliferation 2/969 23/18722 0.335721294239551 0.602913911922988 GOLGB1/MMP14 2 GO:0036303 lymph vessel morphogenesis 2/969 23/18722 0.335721294239551 0.602913911922988 SVEP1/PTPN14 2 GO:0043931 ossification involved in bone maturation 2/969 23/18722 0.335721294239551 0.602913911922988 RHOA/PLXNB1 2 GO:0045980 negative regulation of nucleotide metabolic process 2/969 23/18722 0.335721294239551 0.602913911922988 PARP1/NCOR1 2 GO:0051131 chaperone-mediated protein complex assembly 2/969 23/18722 0.335721294239551 0.602913911922988 PTGES3/HSPA1A 2 GO:0051349 positive regulation of lyase activity 2/969 23/18722 0.335721294239551 0.602913911922988 NF1/TIMP2 2 GO:0051882 mitochondrial depolarization 2/969 23/18722 0.335721294239551 0.602913911922988 PARP1/GCLM 2 GO:0051904 pigment granule transport 2/969 23/18722 0.335721294239551 0.602913911922988 RAB11A/RAB17 2 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2/969 23/18722 0.335721294239551 0.602913911922988 AKAP9/GJA5 2 GO:0060353 regulation of cell adhesion molecule production 2/969 23/18722 0.335721294239551 0.602913911922988 CAV1/COLEC12 2 GO:0060384 innervation 2/969 23/18722 0.335721294239551 0.602913911922988 ISL1/NRP1 2 GO:0060396 growth hormone receptor signaling pathway 2/969 23/18722 0.335721294239551 0.602913911922988 CSH1/PIK3R1 2 GO:0060487 lung epithelial cell differentiation 2/969 23/18722 0.335721294239551 0.602913911922988 NFIB/RBPJ 2 GO:0060575 intestinal epithelial cell differentiation 2/969 23/18722 0.335721294239551 0.602913911922988 IL6ST/KLF5 2 GO:0061050 regulation of cell growth involved in cardiac muscle cell development 2/969 23/18722 0.335721294239551 0.602913911922988 DDX39B/YY1 2 GO:0071305 cellular response to vitamin D 2/969 23/18722 0.335721294239551 0.602913911922988 ATP2B1/TRIM24 2 GO:0071514 genetic imprinting 2/969 23/18722 0.335721294239551 0.602913911922988 IGF2/DNMT3A 2 GO:0072576 liver morphogenesis 2/969 23/18722 0.335721294239551 0.602913911922988 XBP1/CFLAR 2 GO:1903306 negative regulation of regulated secretory pathway 2/969 23/18722 0.335721294239551 0.602913911922988 REST/HMOX1 2 GO:2000810 regulation of bicellular tight junction assembly 2/969 23/18722 0.335721294239551 0.602913911922988 GJA1/ROCK1 2 GO:1905952 regulation of lipid localization 11/969 181/18722 0.335905698579806 0.603037849803526 LRP1/CAV1/ITGAV/PLIN2/ANXA2/CYP19A1/KDM5B/ABCA1/NFKBIA/RXRA/TMF1 11 GO:0006801 superoxide metabolic process 5/969 74/18722 0.336972439238001 0.604745181132484 EGFR/PRDX1/GSTP1/SOD3/BMP7 5 GO:0050867 positive regulation of cell activation 24/969 420/18722 0.337518933368998 0.605518004046132 CAV1/CD46/JUND/MIF/SLC39A10/IGF2/PRKDC/RPS3/SOX4/ANXA1/IL6ST/CTSC/DOCK8/RIF1/GLI3/TFRC/RHOA/MMP14/XBP1/FLOT2/DPP4/GATA3/CD24/HES1 24 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 16/969 273/18722 0.340473209700945 0.610608439909794 CDH1/TENM3/ITGB1/DSC3/DSG2/PTPRF/CADM1/CLDN4/FAT1/PCDH11X/DSC2/MAPK14/WNK1/CLSTN1/OBSL1/CLDN7 16 GO:0070509 calcium ion import 6/969 92/18722 0.341010278587693 0.610680838650804 ATP2B4/TRPV6/LGALS3/HOMER1/AFG3L2/VDAC1 6 GO:0010883 regulation of lipid storage 4/969 57/18722 0.341214705101482 0.610680838650804 ITGAV/PLIN2/ABCA1/NFKBIA 4 GO:0050879 multicellular organismal movement 4/969 57/18722 0.341214705101482 0.610680838650804 GSTO1/GAA/DMD/HOMER1 4 GO:0050881 musculoskeletal movement 4/969 57/18722 0.341214705101482 0.610680838650804 GSTO1/GAA/DMD/HOMER1 4 GO:0051155 positive regulation of striated muscle cell differentiation 4/969 57/18722 0.341214705101482 0.610680838650804 MORF4L2/MMP14/DDX39B/MAPK14 4 GO:0061756 leukocyte adhesion to vascular endothelial cell 4/969 57/18722 0.341214705101482 0.610680838650804 ITGB1/NFAT5/ROCK1/RHOA 4 GO:0007611 learning or memory 15/969 255/18722 0.342353216489491 0.611847965290739 JUN/EGFR/FOS/APP/ITGB1/NF1/SLC6A4/EP300/EIF2AK4/MME/BTG2/KRAS/VDAC1/TPBG/ARF4 15 GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/969 40/18722 0.342797399296032 0.611847965290739 CAMSAP2/TAOK1/STMN1 3 GO:0046365 monosaccharide catabolic process 3/969 40/18722 0.342797399296032 0.611847965290739 ENO1/LRP5/FUT8 3 GO:0070266 necroptotic process 3/969 40/18722 0.342797399296032 0.611847965290739 CAV1/CFLAR/PYGL 3 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 3/969 40/18722 0.342797399296032 0.611847965290739 HSPA1A/NMT1/VDAC2 3 GO:0002698 negative regulation of immune effector process 7/969 110/18722 0.34303760778834 0.611847965290739 CD46/GRN/PRKDC/ANXA1/SERPINB9/LGALS3/HMOX1 7 GO:0006939 smooth muscle contraction 7/969 110/18722 0.34303760778834 0.611847965290739 ATP2B1/CAV1/DLG1/ROCK1/TBX3/ATP2B4/RHOA 7 GO:0032611 interleukin-1 beta production 7/969 110/18722 0.34303760778834 0.611847965290739 APP/HSPB1/ISL1/EGR1/GSTP1/FOXP1/SERPINB1 7 GO:0032651 regulation of interleukin-1 beta production 7/969 110/18722 0.34303760778834 0.611847965290739 APP/HSPB1/ISL1/EGR1/GSTP1/FOXP1/SERPINB1 7 GO:0048259 regulation of receptor-mediated endocytosis 7/969 110/18722 0.34303760778834 0.611847965290739 ITGAV/AAK1/CD63/ANXA2/AHI1/LRPAP1/ATXN2 7 GO:0032612 interleukin-1 production 8/969 128/18722 0.343843789647233 0.612687584262528 APP/ANXA1/HSPB1/ISL1/EGR1/GSTP1/FOXP1/SERPINB1 8 GO:0032652 regulation of interleukin-1 production 8/969 128/18722 0.343843789647233 0.612687584262528 APP/ANXA1/HSPB1/ISL1/EGR1/GSTP1/FOXP1/SERPINB1 8 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 9/969 146/18722 0.34386006212055 0.612687584262528 LGR5/ADGRG1/LGR4/AKAP13/ADRB1/GNAQ/ATP2B4/PDE4B/ABCA1 9 GO:0006024 glycosaminoglycan biosynthetic process 5/969 75/18722 0.347347015506522 0.617637122503261 CLTC/CHPF/GCNT2/HEXA/B3GNT2 5 GO:0033077 T cell differentiation in thymus 5/969 75/18722 0.347347015506522 0.617637122503261 RPS6/ZFP36L1/PRKDC/GLI3/GATA3 5 GO:0045913 positive regulation of carbohydrate metabolic process 5/969 75/18722 0.347347015506522 0.617637122503261 APP/IGF2/DDB1/PMAIP1/SORBS1 5 GO:0048662 negative regulation of smooth muscle cell proliferation 5/969 75/18722 0.347347015506522 0.617637122503261 SF1/GSTP1/RHOA/GNA12/HMOX1 5 GO:0051453 regulation of intracellular pH 5/969 75/18722 0.347347015506522 0.617637122503261 GRN/SLC9A1/ATP6V0E1/TM9SF4/ATP6AP2 5 GO:1903363 negative regulation of cellular protein catabolic process 5/969 75/18722 0.347347015506522 0.617637122503261 RPL11/ANXA2/EIF3H/WAC/TAF9 5 GO:0070371 ERK1 and ERK2 cascade 19/969 330/18722 0.349225471556007 0.620766093316902 EGFR/LRP1/ITGAV/SEMA6A/APP/MIF/ZFP36L1/FBLN1/EIF3A/DUSP6/DUSP1/DLG1/GSTP1/NRP1/GCNT2/CFLAR/CDK1/EZR/TPBG 19 GO:0032088 negative regulation of NF-kappaB transcription factor activity 6/969 93/18722 0.350312557074502 0.622063684427912 TMSB4X/UFL1/ANXA4/BMP7/NFKBIA/DDIT3 6 GO:0097306 cellular response to alcohol 6/969 93/18722 0.350312557074502 0.622063684427912 ATP2B1/CDH1/DAG1/ABCA1/LARP1/DNMT3A 6 GO:0106027 neuron projection organization 6/969 93/18722 0.350312557074502 0.622063684427912 APP/CFL1/IGF1R/PPP1R9A/HOMER1/CDC42 6 GO:0002366 leukocyte activation involved in immune response 16/969 275/18722 0.351168216875085 0.62337129802622 CD46/RPS6/GRN/ANXA1/RIF1/TFRC/FOXP1/LGALS3/EIF2AK4/XBP1/ITFG2/SUPT6H/VAMP2/GATA3/HMOX1/ANXA3 16 GO:0002931 response to ischemia 4/969 58/18722 0.353139851744385 0.623592936907718 CAV1/GJA1/EGR1/REST 4 GO:0006826 iron ion transport 4/969 58/18722 0.353139851744385 0.623592936907718 FTH1/CLTC/TFRC/SLC40A1 4 GO:0010559 regulation of glycoprotein biosynthetic process 4/969 58/18722 0.353139851744385 0.623592936907718 TCF7L2/PAWR/AGO2/ARFGEF1 4 GO:0032387 negative regulation of intracellular transport 4/969 58/18722 0.353139851744385 0.623592936907718 LMAN1/TPR/FERMT1/TXN 4 GO:0043506 regulation of JUN kinase activity 4/969 58/18722 0.353139851744385 0.623592936907718 RPS3/GSTP1/MAP3K4/TAOK3 4 GO:0001702 gastrulation with mouth forming second 2/969 24/18722 0.354872827088319 0.623592936907718 LRP5/AMOT 2 GO:0001779 natural killer cell differentiation 2/969 24/18722 0.354872827088319 0.623592936907718 PBX1/HECTD1 2 GO:0001783 B cell apoptotic process 2/969 24/18722 0.354872827088319 0.623592936907718 SLC39A10/FOXP1 2 GO:0003181 atrioventricular valve morphogenesis 2/969 24/18722 0.354872827088319 0.623592936907718 SOX4/MDM4 2 GO:0010155 regulation of proton transport 2/969 24/18722 0.354872827088319 0.623592936907718 TMSB4X/ACTN4 2 GO:0010288 response to lead ion 2/969 24/18722 0.354872827088319 0.623592936907718 APP/DNMT3A 2 GO:0030810 positive regulation of nucleotide biosynthetic process 2/969 24/18722 0.354872827088319 0.623592936907718 ENO1/TMSB4X 2 GO:0032528 microvillus organization 2/969 24/18722 0.354872827088319 0.623592936907718 KLF5/EZR 2 GO:0032928 regulation of superoxide anion generation 2/969 24/18722 0.354872827088319 0.623592936907718 EGFR/GSTP1 2 GO:0036010 protein localization to endosome 2/969 24/18722 0.354872827088319 0.623592936907718 NRP1/EZR 2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 2/969 24/18722 0.354872827088319 0.623592936907718 GPC1/GATA3 2 GO:0050687 negative regulation of defense response to virus 2/969 24/18722 0.354872827088319 0.623592936907718 PCBP2/HTRA1 2 GO:0050855 regulation of B cell receptor signaling pathway 2/969 24/18722 0.354872827088319 0.623592936907718 SLC39A10/FOXP1 2 GO:0051000 positive regulation of nitric-oxide synthase activity 2/969 24/18722 0.354872827088319 0.623592936907718 CALM1/KRAS 2 GO:0051043 regulation of membrane protein ectodomain proteolysis 2/969 24/18722 0.354872827088319 0.623592936907718 ROCK1/TIMP2 2 GO:0051156 glucose 6-phosphate metabolic process 2/969 24/18722 0.354872827088319 0.623592936907718 TALDO1/PGAM1 2 GO:0051905 establishment of pigment granule localization 2/969 24/18722 0.354872827088319 0.623592936907718 RAB11A/RAB17 2 GO:0060479 lung cell differentiation 2/969 24/18722 0.354872827088319 0.623592936907718 NFIB/RBPJ 2 GO:0060561 apoptotic process involved in morphogenesis 2/969 24/18722 0.354872827088319 0.623592936907718 LRP5/BMP7 2 GO:0070935 3'-UTR-mediated mRNA stabilization 2/969 24/18722 0.354872827088319 0.623592936907718 MAPK14/HNRNPC 2 GO:0071378 cellular response to growth hormone stimulus 2/969 24/18722 0.354872827088319 0.623592936907718 CSH1/PIK3R1 2 GO:0071676 negative regulation of mononuclear cell migration 2/969 24/18722 0.354872827088319 0.623592936907718 DUSP1/MIA3 2 GO:0072530 purine-containing compound transmembrane transport 2/969 24/18722 0.354872827088319 0.623592936907718 SLC25A6/SLC19A1 2 GO:0120255 olefinic compound biosynthetic process 2/969 24/18722 0.354872827088319 0.623592936907718 EGR1/REST 2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2/969 24/18722 0.354872827088319 0.623592936907718 ENO1/TMSB4X 2 GO:0009167 purine ribonucleoside monophosphate metabolic process 3/969 41/18722 0.357166530460224 0.626780486294538 DLG1/IMPDH2/AK2 3 GO:0060612 adipose tissue development 3/969 41/18722 0.357166530460224 0.626780486294538 LRP5/XBP1/ARID5B 3 GO:1900371 regulation of purine nucleotide biosynthetic process 3/969 41/18722 0.357166530460224 0.626780486294538 ENO1/TMSB4X/PARP1 3 GO:1902622 regulation of neutrophil migration 3/969 41/18722 0.357166530460224 0.626780486294538 JAM3/CD99/DPP4 3 GO:0001937 negative regulation of endothelial cell proliferation 5/969 76/18722 0.357739520898938 0.627364676583171 CAV1/GJA1/NR2F2/NF1/CAV2 5 GO:0043536 positive regulation of blood vessel endothelial cell migration 5/969 76/18722 0.357739520898938 0.627364676583171 ANXA1/HSPB1/NRP1/TMSB4X/HMOX1 5 GO:0050905 neuromuscular process 9/969 148/18722 0.358596465969744 0.628445718027458 APP/MYCBP2/GSTO1/GAA/TMEM150C/IGDCC3/DMD/CHD8/HOMER1 9 GO:0097530 granulocyte migration 9/969 148/18722 0.358596465969744 0.628445718027458 CSF3R/ANXA1/PPIA/JAM3/S100A9/PDE4B/CD99/LGALS3/DPP4 9 GO:0006282 regulation of DNA repair 8/969 130/18722 0.359604351088822 0.629843656394709 EGFR/FUS/PRKDC/RPS3/RIF1/PARP1/SETD2/UBR5 8 GO:0032091 negative regulation of protein binding 6/969 94/18722 0.359635183827365 0.629843656394709 CAV1/ROCK1/PTPRF/LRPAP1/ID1/AURKA 6 GO:0001676 long-chain fatty acid metabolic process 7/969 112/18722 0.360058246576084 0.630162222574218 CYP2J2/GPX4/GSTP1/GPX1/PTGES3/SLC27A2/QKI 7 GO:0046632 alpha-beta T cell differentiation 7/969 112/18722 0.360058246576084 0.630162222574218 RPL22/ANXA1/CTSL/GLI3/RHOA/FOXP1/GATA3 7 GO:0006605 protein targeting 18/969 314/18722 0.361746935263845 0.632905752825194 TCAF1/NACA/HSPA5/LMAN1/RPL11/ANK3/GCC2/VPS13C/HUWE1/ZFYVE16/SEC62/VPS13A/GNPTAB/NPEPPS/UBE2L3/YWHAQ/DNAJC15/NDUFA13 18 GO:0034728 nucleosome organization 10/969 167/18722 0.364194578097708 0.636974854464064 BPTF/ATRX/NPM1/BRD2/HP1BP3/ARID1A/SETD2/RSF1/HMGA1/SUPT6H 10 GO:0050890 cognition 17/969 296/18722 0.364514169006606 0.637320524332059 JUN/EGFR/FOS/APP/ITGB1/NIPBL/NF1/SLC6A4/EP300/EIF2AK4/SETD5/MME/BTG2/KRAS/VDAC1/TPBG/ARF4 17 GO:0001836 release of cytochrome c from mitochondria 4/969 59/18722 0.365065253962654 0.63785724413535 JUN/GPX1/PMAIP1/GHITM 4 GO:0019369 arachidonic acid metabolic process 4/969 59/18722 0.365065253962654 0.63785724413535 CYP2J2/GPX4/GPX1/PTGES3 4 GO:0016525 negative regulation of angiogenesis 9/969 149/18722 0.365993804176474 0.63926591598471 SEMA6A/ADAMTS1/COL4A2/ROCK1/GTF2I/ATP2B4/AMOT/EPN2/PGK1 9 GO:0071824 protein-DNA complex subunit organization 14/969 241/18722 0.36729360986011 0.641172126162694 BPTF/ATRX/BDP1/NPM1/BRD2/HP1BP3/ARID1A/SETD2/RSF1/HMGA1/SUPT6H/BAZ2A/CENPN/TAF9 14 GO:0007281 germ cell development 16/969 278/18722 0.36733052922524 0.641172126162694 RPS6/DYNLL1/LGR5/JAM3/AFF4/SMARCA2/DIAPH2/CELF1/SMAD5/ZFX/YTHDC1/QKI/TMF1/CDYL/CCNB1/AURKA 16 GO:0031345 negative regulation of cell projection organization 11/969 186/18722 0.368835965873807 0.643584894042243 LRP1/SEMA6A/KANK1/SEMA6D/NRP1/RHOA/THOC2/RTN4/MYLIP/TACSTD2/ID1 11 GO:0048709 oligodendrocyte differentiation 6/969 95/18722 0.368972532068021 0.643608295256168 DAG1/GSTP1/GLI3/NF1/B4GALT5/HES1 6 GO:0051480 regulation of cytosolic calcium ion concentration 20/969 353/18722 0.370740467092254 0.644327736995353 ATP2B1/LRP1/CAV1/ITGAV/GSTO1/GJA1/GTF2I/DIAPH1/ATP2B4/MCOLN3/TRPV6/DMD/CALM1/DDIT3/SPPL3/CD24/YWHAE/CALM2/CAV2/SRI 20 GO:0007520 myoblast fusion 3/969 42/18722 0.371491403945447 0.644327736995353 MAPK14/CFLAR/MYOF 3 GO:0010591 regulation of lamellipodium assembly 3/969 42/18722 0.371491403945447 0.644327736995353 WASF2/PIK3R1/CDC42 3 GO:0030808 regulation of nucleotide biosynthetic process 3/969 42/18722 0.371491403945447 0.644327736995353 ENO1/TMSB4X/PARP1 3 GO:0030890 positive regulation of B cell proliferation 3/969 42/18722 0.371491403945447 0.644327736995353 MIF/SLC39A10/TFRC 3 GO:0033574 response to testosterone 3/969 42/18722 0.371491403945447 0.644327736995353 DUSP1/CSNK2B/CFLAR 3 GO:0043507 positive regulation of JUN kinase activity 3/969 42/18722 0.371491403945447 0.644327736995353 RPS3/MAP3K4/TAOK3 3 GO:0045292 mRNA cis splicing, via spliceosome 3/969 42/18722 0.371491403945447 0.644327736995353 PRPF4B/PRPF40A/SNRPC 3 GO:0046688 response to copper ion 3/969 42/18722 0.371491403945447 0.644327736995353 APP/SOD3/CDK1 3 GO:0051452 intracellular pH reduction 3/969 42/18722 0.371491403945447 0.644327736995353 GRN/ATP6V0E1/ATP6AP2 3 GO:0090317 negative regulation of intracellular protein transport 3/969 42/18722 0.371491403945447 0.644327736995353 LMAN1/FERMT1/TXN 3 GO:1903432 regulation of TORC1 signaling 3/969 42/18722 0.371491403945447 0.644327736995353 WAC/ITFG2/SEC13 3 GO:0003094 glomerular filtration 2/969 25/18722 0.373823516756584 0.644327736995353 GJA1/GJA5 2 GO:0006312 mitotic recombination 2/969 25/18722 0.373823516756584 0.644327736995353 RAD50/TPRKB 2 GO:0010954 positive regulation of protein processing 2/969 25/18722 0.373823516756584 0.644327736995353 ENO1/MMP14 2 GO:0010996 response to auditory stimulus 2/969 25/18722 0.373823516756584 0.644327736995353 USP53/XPC 2 GO:0015012 heparan sulfate proteoglycan biosynthetic process 2/969 25/18722 0.373823516756584 0.644327736995353 EXTL2/TCF7L2 2 GO:0032104 regulation of response to extracellular stimulus 2/969 25/18722 0.373823516756584 0.644327736995353 TRIM24/NUCB2 2 GO:0032107 regulation of response to nutrient levels 2/969 25/18722 0.373823516756584 0.644327736995353 TRIM24/NUCB2 2 GO:0032331 negative regulation of chondrocyte differentiation 2/969 25/18722 0.373823516756584 0.644327736995353 EFEMP1/LTBP3 2 GO:0032400 melanosome localization 2/969 25/18722 0.373823516756584 0.644327736995353 RAB11A/RAB17 2 GO:0032469 endoplasmic reticulum calcium ion homeostasis 2/969 25/18722 0.373823516756584 0.644327736995353 APP/CCDC47 2 GO:0033233 regulation of protein sumoylation 2/969 25/18722 0.373823516756584 0.644327736995353 EGR1/HMG20B 2 GO:0034389 lipid droplet organization 2/969 25/18722 0.373823516756584 0.644327736995353 PPIA/FAF2 2 GO:0036315 cellular response to sterol 2/969 25/18722 0.373823516756584 0.644327736995353 DAG1/ABCA1 2 GO:0045109 intermediate filament organization 2/969 25/18722 0.373823516756584 0.644327736995353 DSP/PLEC 2 GO:0051204 protein insertion into mitochondrial membrane 2/969 25/18722 0.373823516756584 0.644327736995353 NMT1/NDUFA13 2 GO:0070199 establishment of protein localization to chromosome 2/969 25/18722 0.373823516756584 0.644327736995353 NIPBL/CCT8 2 GO:0072207 metanephric epithelium development 2/969 25/18722 0.373823516756584 0.644327736995353 LGR4/HES1 2 GO:0098703 calcium ion import across plasma membrane 2/969 25/18722 0.373823516756584 0.644327736995353 ATP2B4/TRPV6 2 GO:0099560 synaptic membrane adhesion 2/969 25/18722 0.373823516756584 0.644327736995353 PTPRF/MAPK14 2 GO:1903055 positive regulation of extracellular matrix organization 2/969 25/18722 0.373823516756584 0.644327736995353 DAG1/CFLAR 2 GO:1903792 negative regulation of anion transport 2/969 25/18722 0.373823516756584 0.644327736995353 GABRE/GOPC 2 GO:1903901 negative regulation of viral life cycle 2/969 25/18722 0.373823516756584 0.644327736995353 PPIA/LY6E 2 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2/969 25/18722 0.373823516756584 0.644327736995353 RHOA/GNA12 2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 2/969 25/18722 0.373823516756584 0.644327736995353 NFAT5/RHOA 2 GO:0034660 ncRNA metabolic process 27/969 485/18722 0.37558618924193 0.647152464549399 RPS21/RPL14/RPS6/RPS25/RPL26/RPS8/KCNQ1OT1/RPL10A/RPS16/RPL7A/RPL11/PRKDC/RPL27/RPL7/DDX17/RPL35/IARS2/DICER1/INTS6/ADAR/AGO2/SNU13/EBNA1BP2/NHP2/NOP10/SSB/TPRKB 27 GO:0002712 regulation of B cell mediated immunity 4/969 60/18722 0.376979861875826 0.648911975679534 CD46/RIF1/TFRC/SUPT6H 4 GO:0002889 regulation of immunoglobulin mediated immune response 4/969 60/18722 0.376979861875826 0.648911975679534 CD46/RIF1/TFRC/SUPT6H 4 GO:0006081 cellular aldehyde metabolic process 4/969 60/18722 0.376979861875826 0.648911975679534 TPI1/IDH1/REST/TALDO1 4 GO:0002286 T cell activation involved in immune response 7/969 114/18722 0.377146599693549 0.648985225551033 CD46/RPS6/ANXA1/FOXP1/LGALS3/EIF2AK4/GATA3 7 GO:0030500 regulation of bone mineralization 5/969 78/18722 0.378547658483068 0.650967444301584 FBN2/ATP2B1/TFAP2A/LTBP3/BMP7 5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 5/969 78/18722 0.378547658483068 0.650967444301584 SERPINB9/GPX1/USP47/DHCR24/SIAH2 5 GO:0043535 regulation of blood vessel endothelial cell migration 9/969 151/18722 0.38083266372848 0.654466129774756 ANXA1/HSPB1/NRP1/TMSB4X/NF1/ATP2B4/CSNK2B/RHOA/HMOX1 9 GO:2000181 negative regulation of blood vessel morphogenesis 9/969 151/18722 0.38083266372848 0.654466129774756 SEMA6A/ADAMTS1/COL4A2/ROCK1/GTF2I/ATP2B4/AMOT/EPN2/PGK1 9 GO:0008037 cell recognition 13/969 225/18722 0.382147854572651 0.65651041682994 ALDOA/APP/DOCK8/DLG1/NRP1/CADM1/SPESP1/LGALS3/COLEC12/RTN4/VDAC2/LY6K/CCT8 13 GO:0006997 nucleus organization 8/969 133/18722 0.38337165092873 0.658396400839153 SF1/PLEC/TPR/NEK6/BAZ2A/RTN4/TMF1/CDK1 8 GO:0071675 regulation of mononuclear cell migration 7/969 115/18722 0.385705520864454 0.659886761487025 APP/DUSP1/DOCK8/MIA3/RHOA/LGALS3/WNK1 7 GO:0001504 neurotransmitter uptake 3/969 43/18722 0.385754698879231 0.659886761487025 ITGB1/SLC38A1/SLC6A4 3 GO:0006284 base-excision repair 3/969 43/18722 0.385754698879231 0.659886761487025 RPS3/USP47/HUWE1 3 GO:0006509 membrane protein ectodomain proteolysis 3/969 43/18722 0.385754698879231 0.659886761487025 DAG1/ROCK1/TIMP2 3 GO:0014014 negative regulation of gliogenesis 3/969 43/18722 0.385754698879231 0.659886761487025 NF1/DICER1/HES1 3 GO:0036230 granulocyte activation 3/969 43/18722 0.385754698879231 0.659886761487025 GRN/VAMP2/ANXA3 3 GO:0042181 ketone biosynthetic process 3/969 43/18722 0.385754698879231 0.659886761487025 TPI1/EGR1/REST 3 GO:0045981 positive regulation of nucleotide metabolic process 3/969 43/18722 0.385754698879231 0.659886761487025 APP/ENO1/TMSB4X 3 GO:0140353 lipid export from cell 3/969 43/18722 0.385754698879231 0.659886761487025 CYP19A1/KDM5B/TMF1 3 GO:1900544 positive regulation of purine nucleotide metabolic process 3/969 43/18722 0.385754698879231 0.659886761487025 APP/ENO1/TMSB4X 3 GO:1901381 positive regulation of potassium ion transmembrane transport 3/969 43/18722 0.385754698879231 0.659886761487025 AKAP9/KCNN4/WNK1 3 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 3/969 43/18722 0.385754698879231 0.659886761487025 HSPA1A/MCL1/HSPA1B 3 GO:0070167 regulation of biomineral tissue development 6/969 97/18722 0.387669369574699 0.662945067211183 FBN2/ATP2B1/ROCK1/TFAP2A/LTBP3/BMP7 6 GO:1901343 negative regulation of vasculature development 9/969 152/18722 0.388268613724147 0.66375262522813 SEMA6A/ADAMTS1/COL4A2/ROCK1/GTF2I/ATP2B4/AMOT/EPN2/PGK1 9 GO:0030199 collagen fibril organization 4/969 61/18722 0.388873031572727 0.663917171838965 COL14A1/ANXA2/NF1/SERPINH1 4 GO:0043030 regulation of macrophage activation 4/969 61/18722 0.388873031572727 0.663917171838965 JUND/MIF/GRN/CTSC 4 GO:0043954 cellular component maintenance 4/969 61/18722 0.388873031572727 0.663917171838965 DLG1/IGF1R/ERC1/HOMER1 4 GO:1905515 non-motile cilium assembly 4/969 61/18722 0.388873031572727 0.663917171838965 CEP350/PCM1/ATMIN/TMEM107 4 GO:0001556 oocyte maturation 2/969 26/18722 0.39254285942176 0.664968876284641 CCNB1/AURKA 2 GO:0002092 positive regulation of receptor internalization 2/969 26/18722 0.39254285942176 0.664968876284641 CD63/AHI1 2 GO:0006027 glycosaminoglycan catabolic process 2/969 26/18722 0.39254285942176 0.664968876284641 GNS/NAGLU 2 GO:0006517 protein deglycosylation 2/969 26/18722 0.39254285942176 0.664968876284641 MAN2A1/MAN1A2 2 GO:0006760 folic acid-containing compound metabolic process 2/969 26/18722 0.39254285942176 0.664968876284641 SLC19A1/GGH 2 GO:0014829 vascular associated smooth muscle contraction 2/969 26/18722 0.39254285942176 0.664968876284641 ATP2B1/RHOA 2 GO:0018027 peptidyl-lysine dimethylation 2/969 26/18722 0.39254285942176 0.664968876284641 ASH1L/SETD2 2 GO:0021952 central nervous system projection neuron axonogenesis 2/969 26/18722 0.39254285942176 0.664968876284641 MYCBP2/NFIB 2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/969 26/18722 0.39254285942176 0.664968876284641 ARMCX3/UXT 2 GO:0042634 regulation of hair cycle 2/969 26/18722 0.39254285942176 0.664968876284641 NIPBL/FERMT1 2 GO:0043501 skeletal muscle adaptation 2/969 26/18722 0.39254285942176 0.664968876284641 CFLAR/CAMK2G 2 GO:0046639 negative regulation of alpha-beta T cell differentiation 2/969 26/18722 0.39254285942176 0.664968876284641 ANXA1/GLI3 2 GO:0047497 mitochondrion transport along microtubule 2/969 26/18722 0.39254285942176 0.664968876284641 ARMCX3/UXT 2 GO:0048668 collateral sprouting 2/969 26/18722 0.39254285942176 0.664968876284641 LRP1/APP 2 GO:0051350 negative regulation of lyase activity 2/969 26/18722 0.39254285942176 0.664968876284641 AKAP9/PHPT1 2 GO:0051875 pigment granule localization 2/969 26/18722 0.39254285942176 0.664968876284641 RAB11A/RAB17 2 GO:0060544 regulation of necroptotic process 2/969 26/18722 0.39254285942176 0.664968876284641 CAV1/CFLAR 2 GO:0070977 bone maturation 2/969 26/18722 0.39254285942176 0.664968876284641 RHOA/PLXNB1 2 GO:0072273 metanephric nephron morphogenesis 2/969 26/18722 0.39254285942176 0.664968876284641 LGR4/HES1 2 GO:0097205 renal filtration 2/969 26/18722 0.39254285942176 0.664968876284641 GJA1/GJA5 2 GO:1902186 regulation of viral release from host cell 2/969 26/18722 0.39254285942176 0.664968876284641 DDB1/CAV2 2 GO:1902656 calcium ion import into cytosol 2/969 26/18722 0.39254285942176 0.664968876284641 ATP2B4/TRPV6 2 GO:1904353 regulation of telomere capping 2/969 26/18722 0.39254285942176 0.664968876284641 MAP3K4/RAD50 2 GO:2000050 regulation of non-canonical Wnt signaling pathway 2/969 26/18722 0.39254285942176 0.664968876284641 ZNRF3/RNF213 2 GO:0120254 olefinic compound metabolic process 9/969 153/18722 0.395711904901825 0.670120030789674 CYP2J2/CYP11A1/GPX4/EGR1/GSTP1/GPX1/PTGES3/AKR1B1/REST 9 GO:0032642 regulation of chemokine production 6/969 98/18722 0.397018108044923 0.670443067849727 LRP1/APP/EGR1/GSTP1/FOXP1/HMOX1 6 GO:0043473 pigmentation 6/969 98/18722 0.397018108044923 0.670443067849727 CD63/GLI3/NF1/RAB11A/ATP6AP2/RAB17 6 GO:0002221 pattern recognition receptor signaling pathway 10/969 172/18722 0.399243140671244 0.670443067849727 CAV1/LGR4/PUM1/HSPA1A/ANKRD17/PUM2/COLEC12/RTN4/NFKBIA/HSPA1B 10 GO:0002066 columnar/cuboidal epithelial cell development 3/969 44/18722 0.3999401438043 0.670443067849727 CDK6/IL6ST/KLF5 3 GO:0007528 neuromuscular junction development 3/969 44/18722 0.3999401438043 0.670443067849727 APP/ANK3/AFG3L2 3 GO:0009126 purine nucleoside monophosphate metabolic process 3/969 44/18722 0.3999401438043 0.670443067849727 DLG1/IMPDH2/AK2 3 GO:0031295 T cell costimulation 3/969 44/18722 0.3999401438043 0.670443067849727 CAV1/DPP4/CD24 3 GO:0032881 regulation of polysaccharide metabolic process 3/969 44/18722 0.3999401438043 0.670443067849727 IGF2/CLTC/SORBS1 3 GO:0046006 regulation of activated T cell proliferation 3/969 44/18722 0.3999401438043 0.670443067849727 IGF2/RPS3/CD24 3 GO:0048066 developmental pigmentation 3/969 44/18722 0.3999401438043 0.670443067849727 CD63/GLI3/ATP6AP2 3 GO:0089718 amino acid import across plasma membrane 3/969 44/18722 0.3999401438043 0.670443067849727 ITGB1/SLC1A5/SLC3A2 3 GO:0150076 neuroinflammatory response 3/969 44/18722 0.3999401438043 0.670443067849727 ITGB1/GRN/CTSC 3 GO:0032731 positive regulation of interleukin-1 beta production 4/969 62/18722 0.400734532682674 0.670443067849727 APP/HSPB1/ISL1/EGR1 4 GO:0048663 neuron fate commitment 4/969 62/18722 0.400734532682674 0.670443067849727 ISL1/GLI3/RBPJ/CDC42 4 GO:0015849 organic acid transport 17/969 303/18722 0.401386815838805 0.670443067849727 LRP2/SLC26A2/ITGB1/CROT/SLC2A1/GJA1/ANXA1/PLIN2/SLC38A1/SLC38A2/SLC27A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2/SLC19A1/SLC13A3 17 GO:0050770 regulation of axonogenesis 9/969 154/18722 0.40315981823725 0.670443067849727 LRP1/GOLGA4/SEMA6A/MACF1/SEMA6D/NRP1/RAB11A/PLXNB1/RTN4 9 GO:0032602 chemokine production 6/969 99/18722 0.406360077980825 0.670443067849727 LRP1/APP/EGR1/GSTP1/FOXP1/HMOX1 6 GO:0110149 regulation of biomineralization 6/969 99/18722 0.406360077980825 0.670443067849727 FBN2/ATP2B1/ROCK1/TFAP2A/LTBP3/BMP7 6 GO:0030641 regulation of cellular pH 5/969 81/18722 0.409707684148696 0.670443067849727 GRN/SLC9A1/ATP6V0E1/TM9SF4/ATP6AP2 5 GO:2000106 regulation of leukocyte apoptotic process 5/969 81/18722 0.409707684148696 0.670443067849727 SLC39A10/ANXA1/DOCK8/FOXP1/LGALS3 5 GO:0000469 cleavage involved in rRNA processing 2/969 27/18722 0.411004040163915 0.670443067849727 RPS21/NHP2 2 GO:0007026 negative regulation of microtubule depolymerization 2/969 27/18722 0.411004040163915 0.670443067849727 CAMSAP2/TAOK1 2 GO:0007263 nitric oxide mediated signal transduction 2/969 27/18722 0.411004040163915 0.670443067849727 EGFR/ATP2B4 2 GO:0018126 protein hydroxylation 2/969 27/18722 0.411004040163915 0.670443067849727 ASPH/P4HB 2 GO:0032703 negative regulation of interleukin-2 production 2/969 27/18722 0.411004040163915 0.670443067849727 GATA3/EZR 2 GO:0032781 positive regulation of ATPase activity 2/969 27/18722 0.411004040163915 0.670443067849727 PFN1/DNAJB1 2 GO:0045830 positive regulation of isotype switching 2/969 27/18722 0.411004040163915 0.670443067849727 RIF1/TFRC 2 GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/969 27/18722 0.411004040163915 0.670443067849727 MAPK14/CFLAR 2 GO:0070861 regulation of protein exit from endoplasmic reticulum 2/969 27/18722 0.411004040163915 0.670443067849727 GCC2/TM9SF4 2 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2/969 27/18722 0.411004040163915 0.670443067849727 AKAP9/GJA5 2 GO:1900746 regulation of vascular endothelial growth factor signaling pathway 2/969 27/18722 0.411004040163915 0.670443067849727 SEMA6A/CD63 2 GO:1902883 negative regulation of response to oxidative stress 2/969 27/18722 0.411004040163915 0.670443067849727 MET/TXN 2 GO:0001820 serotonin secretion 1/969 10/18722 0.412323769626679 0.670443067849727 SLC6A4 1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1/969 10/18722 0.412323769626679 0.670443067849727 LGALS3 1 GO:0002524 hypersensitivity 1/969 10/18722 0.412323769626679 0.670443067849727 GATA3 1 GO:0002887 negative regulation of myeloid leukocyte mediated immunity 1/969 10/18722 0.412323769626679 0.670443067849727 HMOX1 1 GO:0003183 mitral valve morphogenesis 1/969 10/18722 0.412323769626679 0.670443067849727 SOX4 1 GO:0005984 disaccharide metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 GAA 1 GO:0006646 phosphatidylethanolamine biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 PISD 1 GO:0006735 NADH regeneration 1/969 10/18722 0.412323769626679 0.670443067849727 ENO1 1 GO:0009133 nucleoside diphosphate biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 AK2 1 GO:0010172 embryonic body morphogenesis 1/969 10/18722 0.412323769626679 0.670443067849727 DAG1 1 GO:0010992 ubiquitin recycling 1/969 10/18722 0.412323769626679 0.670443067849727 UBE2C 1 GO:0015808 L-alanine transport 1/969 10/18722 0.412323769626679 0.670443067849727 SLC3A2 1 GO:0015911 long-chain fatty acid import across plasma membrane 1/969 10/18722 0.412323769626679 0.670443067849727 SLC2A1 1 GO:0018242 protein O-linked glycosylation via serine 1/969 10/18722 0.412323769626679 0.670443067849727 GALNT1 1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 1/969 10/18722 0.412323769626679 0.670443067849727 P4HB 1 GO:0019532 oxalate transport 1/969 10/18722 0.412323769626679 0.670443067849727 SLC26A2 1 GO:0021548 pons development 1/969 10/18722 0.412323769626679 0.670443067849727 UQCRQ 1 GO:0022400 regulation of rhodopsin mediated signaling pathway 1/969 10/18722 0.412323769626679 0.670443067849727 NMT1 1 GO:0030388 fructose 1,6-bisphosphate metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 ALDOA 1 GO:0030638 polyketide metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 AKR1B1 1 GO:0030647 aminoglycoside antibiotic metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 AKR1B1 1 GO:0031125 rRNA 3'-end processing 1/969 10/18722 0.412323769626679 0.670443067849727 RPS21 1 GO:0031642 negative regulation of myelination 1/969 10/18722 0.412323769626679 0.670443067849727 CTSC 1 GO:0031915 positive regulation of synaptic plasticity 1/969 10/18722 0.412323769626679 0.670443067849727 CDC20 1 GO:0031943 regulation of glucocorticoid metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 REST 1 GO:0032253 dense core granule localization 1/969 10/18722 0.412323769626679 0.670443067849727 KIF5B 1 GO:0032342 aldosterone biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 REST 1 GO:0032380 regulation of intracellular sterol transport 1/969 10/18722 0.412323769626679 0.670443067849727 ANXA2 1 GO:0032383 regulation of intracellular cholesterol transport 1/969 10/18722 0.412323769626679 0.670443067849727 ANXA2 1 GO:0033131 regulation of glucokinase activity 1/969 10/18722 0.412323769626679 0.670443067849727 RANBP2 1 GO:0034085 establishment of sister chromatid cohesion 1/969 10/18722 0.412323769626679 0.670443067849727 NIPBL 1 GO:0034651 cortisol biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 REST 1 GO:0035376 sterol import 1/969 10/18722 0.412323769626679 0.670443067849727 LRP1 1 GO:0035520 monoubiquitinated protein deubiquitination 1/969 10/18722 0.412323769626679 0.670443067849727 USP47 1 GO:0035646 endosome to melanosome transport 1/969 10/18722 0.412323769626679 0.670443067849727 CD63 1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway 1/969 10/18722 0.412323769626679 0.670443067849727 GATA3 1 GO:0035907 dorsal aorta development 1/969 10/18722 0.412323769626679 0.670443067849727 RBPJ 1 GO:0040015 negative regulation of multicellular organism growth 1/969 10/18722 0.412323769626679 0.670443067849727 ADRB1 1 GO:0042045 epithelial fluid transport 1/969 10/18722 0.412323769626679 0.670443067849727 AHCYL1 1 GO:0042996 regulation of Golgi to plasma membrane protein transport 1/969 10/18722 0.412323769626679 0.670443067849727 GOPC 1 GO:0043485 endosome to pigment granule transport 1/969 10/18722 0.412323769626679 0.670443067849727 CD63 1 GO:0044598 doxorubicin metabolic process 1/969 10/18722 0.412323769626679 0.670443067849727 AKR1B1 1 GO:0044848 biological phase 1/969 10/18722 0.412323769626679 0.670443067849727 FERMT1 1 GO:0045348 positive regulation of MHC class II biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 XBP1 1 GO:0045625 regulation of T-helper 1 cell differentiation 1/969 10/18722 0.412323769626679 0.670443067849727 ANXA1 1 GO:0045792 negative regulation of cell size 1/969 10/18722 0.412323769626679 0.670443067849727 RHOA 1 GO:0048241 epinephrine transport 1/969 10/18722 0.412323769626679 0.670443067849727 LY6E 1 GO:0048251 elastic fiber assembly 1/969 10/18722 0.412323769626679 0.670443067849727 LTBP3 1 GO:0048262 determination of dorsal/ventral asymmetry 1/969 10/18722 0.412323769626679 0.670443067849727 DDIT3 1 GO:0048672 positive regulation of collateral sprouting 1/969 10/18722 0.412323769626679 0.670443067849727 LRP1 1 GO:0048703 embryonic viscerocranium morphogenesis 1/969 10/18722 0.412323769626679 0.670443067849727 NIPBL 1 GO:0048757 pigment granule maturation 1/969 10/18722 0.412323769626679 0.670443067849727 CD63 1 GO:0060068 vagina development 1/969 10/18722 0.412323769626679 0.670443067849727 LRP2 1 GO:0060272 embryonic skeletal joint morphogenesis 1/969 10/18722 0.412323769626679 0.670443067849727 BMP7 1 GO:0060513 prostatic bud formation 1/969 10/18722 0.412323769626679 0.670443067849727 BMP7 1 GO:0060736 prostate gland growth 1/969 10/18722 0.412323769626679 0.670443067849727 PSAP 1 GO:0061140 lung secretory cell differentiation 1/969 10/18722 0.412323769626679 0.670443067849727 NFIB 1 GO:0061621 canonical glycolysis 1/969 10/18722 0.412323769626679 0.670443067849727 ENO1 1 GO:0061718 glucose catabolic process to pyruvate 1/969 10/18722 0.412323769626679 0.670443067849727 ENO1 1 GO:0070091 glucagon secretion 1/969 10/18722 0.412323769626679 0.670443067849727 SYT7 1 GO:0070092 regulation of glucagon secretion 1/969 10/18722 0.412323769626679 0.670443067849727 SYT7 1 GO:0070391 response to lipoteichoic acid 1/969 10/18722 0.412323769626679 0.670443067849727 MAPK14 1 GO:0070508 cholesterol import 1/969 10/18722 0.412323769626679 0.670443067849727 LRP1 1 GO:0070544 histone H3-K36 demethylation 1/969 10/18722 0.412323769626679 0.670443067849727 KDM2A 1 GO:0070561 vitamin D receptor signaling pathway 1/969 10/18722 0.412323769626679 0.670443067849727 TRIM24 1 GO:0071223 cellular response to lipoteichoic acid 1/969 10/18722 0.412323769626679 0.670443067849727 MAPK14 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/969 10/18722 0.412323769626679 0.670443067849727 GCLM 1 GO:0071803 positive regulation of podosome assembly 1/969 10/18722 0.412323769626679 0.670443067849727 RHOA 1 GO:0072378 blood coagulation, fibrin clot formation 1/969 10/18722 0.412323769626679 0.670443067849727 FBLN1 1 GO:0090043 regulation of tubulin deacetylation 1/969 10/18722 0.412323769626679 0.670443067849727 EP300 1 GO:0097084 vascular associated smooth muscle cell development 1/969 10/18722 0.412323769626679 0.670443067849727 HES1 1 GO:0097250 mitochondrial respirasome assembly 1/969 10/18722 0.412323769626679 0.670443067849727 HIGD1A 1 GO:0098903 regulation of membrane repolarization during action potential 1/969 10/18722 0.412323769626679 0.670443067849727 CAV1 1 GO:0098917 retrograde trans-synaptic signaling 1/969 10/18722 0.412323769626679 0.670443067849727 DAG1 1 GO:0099171 presynaptic modulation of chemical synaptic transmission 1/969 10/18722 0.412323769626679 0.670443067849727 RPL22 1 GO:0099519 dense core granule cytoskeletal transport 1/969 10/18722 0.412323769626679 0.670443067849727 KIF5B 1 GO:0099532 synaptic vesicle endosomal processing 1/969 10/18722 0.412323769626679 0.670443067849727 EEA1 1 GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/969 10/18722 0.412323769626679 0.670443067849727 RAB11A 1 GO:1901203 positive regulation of extracellular matrix assembly 1/969 10/18722 0.412323769626679 0.670443067849727 DAG1 1 GO:1901725 regulation of histone deacetylase activity 1/969 10/18722 0.412323769626679 0.670443067849727 KDM5A 1 GO:1901950 dense core granule transport 1/969 10/18722 0.412323769626679 0.670443067849727 KIF5B 1 GO:1901978 positive regulation of cell cycle checkpoint 1/969 10/18722 0.412323769626679 0.670443067849727 TPR 1 GO:1902645 tertiary alcohol biosynthetic process 1/969 10/18722 0.412323769626679 0.670443067849727 REST 1 GO:1902855 regulation of non-motile cilium assembly 1/969 10/18722 0.412323769626679 0.670443067849727 ATMIN 1 GO:1903980 positive regulation of microglial cell activation 1/969 10/18722 0.412323769626679 0.670443067849727 CTSC 1 GO:1904851 positive regulation of establishment of protein localization to telomere 1/969 10/18722 0.412323769626679 0.670443067849727 CCT8 1 GO:1905456 regulation of lymphoid progenitor cell differentiation 1/969 10/18722 0.412323769626679 0.670443067849727 HES1 1 GO:1905941 positive regulation of gonad development 1/969 10/18722 0.412323769626679 0.670443067849727 CITED2 1 GO:1990253 cellular response to leucine starvation 1/969 10/18722 0.412323769626679 0.670443067849727 EIF2AK4 1 GO:1990535 neuron projection maintenance 1/969 10/18722 0.412323769626679 0.670443067849727 APP 1 GO:1990700 nucleolar chromatin organization 1/969 10/18722 0.412323769626679 0.670443067849727 BAZ2A 1 GO:2000018 regulation of male gonad development 1/969 10/18722 0.412323769626679 0.670443067849727 CITED2 1 GO:2000121 regulation of removal of superoxide radicals 1/969 10/18722 0.412323769626679 0.670443067849727 BMP7 1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation 1/969 10/18722 0.412323769626679 0.670443067849727 WASF2 1 GO:2001223 negative regulation of neuron migration 1/969 10/18722 0.412323769626679 0.670443067849727 ADGRG1 1 GO:2001225 regulation of chloride transport 1/969 10/18722 0.412323769626679 0.670443067849727 GABRE 1 GO:0045619 regulation of lymphocyte differentiation 10/969 174/18722 0.413311279485391 0.671341557460281 CD46/ZFP36L1/PRKDC/SOX4/ANXA1/GLI3/RHOA/MMP14/XBP1/GATA3 10 GO:0022602 ovulation cycle process 3/969 45/18722 0.414032498984785 0.671341557460281 HSPA5/ADAMTS1/NRIP1 3 GO:0044088 regulation of vacuole organization 3/969 45/18722 0.414032498984785 0.671341557460281 GRN/ANXA2/RAB3GAP2 3 GO:0045933 positive regulation of muscle contraction 3/969 45/18722 0.414032498984785 0.671341557460281 GSTO1/ENO1/RHOA 3 GO:0048546 digestive tract morphogenesis 3/969 45/18722 0.414032498984785 0.671341557460281 NIPBL/GLI3/AHI1 3 GO:0048599 oocyte development 3/969 45/18722 0.414032498984785 0.671341557460281 ZFX/CCNB1/AURKA 3 GO:0085029 extracellular matrix assembly 3/969 45/18722 0.414032498984785 0.671341557460281 LAMB1/DAG1/LTBP3 3 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 3/969 45/18722 0.414032498984785 0.671341557460281 HSPA1A/NMT1/VDAC2 3 GO:2000273 positive regulation of signaling receptor activity 3/969 45/18722 0.414032498984785 0.671341557460281 ITGB1/NCOA3/NRP1 3 GO:0006626 protein targeting to mitochondrion 6/969 100/18722 0.415690190092097 0.673820388778318 LMAN1/HUWE1/NPEPPS/UBE2L3/DNAJC15/NDUFA13 6 GO:0002312 B cell activation involved in immune response 5/969 82/18722 0.420052524805588 0.680469465168631 RIF1/TFRC/XBP1/ITFG2/SUPT6H 5 GO:0007032 endosome organization 5/969 82/18722 0.420052524805588 0.680469465168631 EEA1/HOOK2/RAB11A/HOOK3/USP8 5 GO:0050777 negative regulation of immune response 11/969 194/18722 0.422179107698759 0.68234908666776 CD46/GRN/ANXA1/SERPINB9/GPX1/LGALS3/ADAR/MAPK14/PCBP2/HTRA1/HMOX1 11 GO:0030858 positive regulation of epithelial cell differentiation 4/969 64/18722 0.424323707196529 0.68234908666776 NCOA3/BTG1/AHI1/CD24 4 GO:0030888 regulation of B cell proliferation 4/969 64/18722 0.424323707196529 0.68234908666776 MIF/SLC39A10/TFRC/PAWR 4 GO:0045670 regulation of osteoclast differentiation 4/969 64/18722 0.424323707196529 0.68234908666776 FBN1/FOS/PIK3R1/ESRRA 4 GO:0046579 positive regulation of Ras protein signal transduction 4/969 64/18722 0.424323707196529 0.68234908666776 ADGRG1/AKAP13/KRAS/DYNLT1 4 GO:0050771 negative regulation of axonogenesis 4/969 64/18722 0.424323707196529 0.68234908666776 SEMA6A/SEMA6D/NRP1/RTN4 4 GO:1903018 regulation of glycoprotein metabolic process 4/969 64/18722 0.424323707196529 0.68234908666776 TCF7L2/PAWR/AGO2/ARFGEF1 4 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/969 64/18722 0.424323707196529 0.68234908666776 RPL11/EIF3H/WAC/TAF9 4 GO:1902600 proton transmembrane transport 9/969 157/18722 0.42550457956908 0.68234908666776 TMSB4X/COX6A1/UQCRH/SLC9A1/ATP6V0E1/COX5A/ACTN4/COX7B/STOML2 9 GO:0001974 blood vessel remodeling 3/969 46/18722 0.428017535445585 0.68234908666776 EPAS1/JAG1/RBPJ 3 GO:0007019 microtubule depolymerization 3/969 46/18722 0.428017535445585 0.68234908666776 CAMSAP2/TAOK1/STMN1 3 GO:0010828 positive regulation of glucose transmembrane transport 3/969 46/18722 0.428017535445585 0.68234908666776 PIK3R1/SORBS1/MAPK14 3 GO:0031294 lymphocyte costimulation 3/969 46/18722 0.428017535445585 0.68234908666776 CAV1/DPP4/CD24 3 GO:0034198 cellular response to amino acid starvation 3/969 46/18722 0.428017535445585 0.68234908666776 SLC38A2/EIF2AK4/ITFG2 3 GO:0043462 regulation of ATPase activity 3/969 46/18722 0.428017535445585 0.68234908666776 PFN1/DNAJB1/CNN3 3 GO:0043616 keratinocyte proliferation 3/969 46/18722 0.428017535445585 0.68234908666776 ZFP36L1/FERMT1/SRSF6 3 GO:0045851 pH reduction 3/969 46/18722 0.428017535445585 0.68234908666776 GRN/ATP6V0E1/ATP6AP2 3 GO:0061028 establishment of endothelial barrier 3/969 46/18722 0.428017535445585 0.68234908666776 ROCK1/VCL/EZR 3 GO:0072599 establishment of protein localization to endoplasmic reticulum 3/969 46/18722 0.428017535445585 0.68234908666776 HSPA5/SEC62/RAB3GAP2 3 GO:2000107 negative regulation of leukocyte apoptotic process 3/969 46/18722 0.428017535445585 0.68234908666776 SLC39A10/DOCK8/FOXP1 3 GO:0071774 response to fibroblast growth factor 7/969 120/18722 0.428483542729755 0.68234908666776 IER2/ZFP36L1/KDM5B/GPC1/SETX/GCLM/GATA3 7 GO:0002313 mature B cell differentiation involved in immune response 2/969 28/18722 0.429183633492688 0.68234908666776 XBP1/ITFG2 2 GO:0003156 regulation of animal organ formation 2/969 28/18722 0.429183633492688 0.68234908666776 BMP7/CITED2 2 GO:0010464 regulation of mesenchymal cell proliferation 2/969 28/18722 0.429183633492688 0.68234908666776 LRP5/NFIB 2 GO:0010575 positive regulation of vascular endothelial growth factor production 2/969 28/18722 0.429183633492688 0.68234908666776 IL6ST/ISL1 2 GO:0010818 T cell chemotaxis 2/969 28/18722 0.429183633492688 0.68234908666776 PLEC/WNK1 2 GO:0015740 C4-dicarboxylate transport 2/969 28/18722 0.429183633492688 0.68234908666776 SLC1A5/SLC13A3 2 GO:0019098 reproductive behavior 2/969 28/18722 0.429183633492688 0.68234908666776 APP/ZFX 2 GO:0034123 positive regulation of toll-like receptor signaling pathway 2/969 28/18722 0.429183633492688 0.68234908666776 CAV1/RTN4 2 GO:0042983 amyloid precursor protein biosynthetic process 2/969 28/18722 0.429183633492688 0.68234908666776 PAWR/AGO2 2 GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/969 28/18722 0.429183633492688 0.68234908666776 PAWR/AGO2 2 GO:0045671 negative regulation of osteoclast differentiation 2/969 28/18722 0.429183633492688 0.68234908666776 FBN1/PIK3R1 2 GO:0045686 negative regulation of glial cell differentiation 2/969 28/18722 0.429183633492688 0.68234908666776 NF1/HES1 2 GO:0086011 membrane repolarization during action potential 2/969 28/18722 0.429183633492688 0.68234908666776 CAV1/YWHAE 2 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2/969 28/18722 0.429183633492688 0.68234908666776 AKAP9/GJA5 2 GO:1903671 negative regulation of sprouting angiogenesis 2/969 28/18722 0.429183633492688 0.68234908666776 SEMA6A/EPN2 2 GO:0032677 regulation of interleukin-8 production 6/969 102/18722 0.434295103706551 0.68234908666776 ANXA1/TMSB4X/HSPA1A/ANXA4/DDIT3/HSPA1B 6 GO:1990542 mitochondrial transmembrane transport 6/969 102/18722 0.434295103706551 0.68234908666776 SLC25A36/SLC25A6/AFG3L2/VDAC1/DNAJC15/STOML2 6 GO:0015909 long-chain fatty acid transport 4/969 65/18722 0.436033029068962 0.68234908666776 SLC2A1/ANXA1/PLIN2/SLC27A2 4 GO:0038034 signal transduction in absence of ligand 4/969 65/18722 0.436033029068962 0.68234908666776 ITGAV/HSPA1A/MCL1/HSPA1B 4 GO:0045453 bone resorption 4/969 65/18722 0.436033029068962 0.68234908666776 EGFR/NF1/TFRC/LTBP3 4 GO:0060389 pathway-restricted SMAD protein phosphorylation 4/969 65/18722 0.436033029068962 0.68234908666776 LRP1/TGFBR3/CSNK2B/BMP7 4 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 4/969 65/18722 0.436033029068962 0.68234908666776 ITGAV/HSPA1A/MCL1/HSPA1B 4 GO:0034612 response to tumor necrosis factor 14/969 253/18722 0.437639684246422 0.68234908666776 KRT8/KRT18/ZFP36L1/RPS3/GSTP1/TMSB4X/HSPA1A/EIF5A/MAPK14/ACTN4/NFKBIA/HSPA1B/GATA3/CASP4 14 GO:0016236 macroautophagy 16/969 291/18722 0.43834811048367 0.68234908666776 GAPDH/UFL1/VPS13C/HUWE1/EXOC1/RB1CC1/SMG1/ATP6V0E1/LARP1/CALM1/WAC/RAB3GAP2/UVRAG/HMOX1/VDAC1/UFC1 16 GO:0015748 organophosphate ester transport 8/969 140/18722 0.438951844973814 0.68234908666776 GJA1/SLC25A36/KCNN4/ABCA1/ATP10D/SLC25A6/SLC19A1/NPC2 8 GO:0097061 dendritic spine organization 5/969 84/18722 0.440640128114694 0.68234908666776 CFL1/IGF1R/PPP1R9A/HOMER1/CDC42 5 GO:0001774 microglial cell activation 3/969 47/18722 0.44188201124724 0.68234908666776 APP/GRN/CTSC 3 GO:0007595 lactation 3/969 47/18722 0.44188201124724 0.68234908666776 CAV1/PRLR/XBP1 3 GO:0016073 snRNA metabolic process 3/969 47/18722 0.44188201124724 0.68234908666776 INTS6/NHP2/NOP10 3 GO:0019884 antigen processing and presentation of exogenous antigen 3/969 47/18722 0.44188201124724 0.68234908666776 CTSL/CTSD/CTSV 3 GO:0032008 positive regulation of TOR signaling 3/969 47/18722 0.44188201124724 0.68234908666776 RICTOR/WAC/SEC13 3 GO:0045332 phospholipid translocation 3/969 47/18722 0.44188201124724 0.68234908666776 KCNN4/ABCA1/ATP10D 3 GO:0046677 response to antibiotic 3/969 47/18722 0.44188201124724 0.68234908666776 HSPA5/KDM5B/SLC9A1 3 GO:0050798 activated T cell proliferation 3/969 47/18722 0.44188201124724 0.68234908666776 IGF2/RPS3/CD24 3 GO:0050885 neuromuscular process controlling balance 3/969 47/18722 0.44188201124724 0.68234908666776 APP/GAA/IGDCC3 3 GO:0090279 regulation of calcium ion import 3/969 47/18722 0.44188201124724 0.68234908666776 LGALS3/HOMER1/VDAC1 3 GO:0097028 dendritic cell differentiation 3/969 47/18722 0.44188201124724 0.68234908666776 DHRS2/ITGB8/RBPJ 3 GO:0097300 programmed necrotic cell death 3/969 47/18722 0.44188201124724 0.68234908666776 CAV1/CFLAR/PYGL 3 GO:0001967 suckling behavior 1/969 11/18722 0.442756554322689 0.68234908666776 APP 1 GO:0002327 immature B cell differentiation 1/969 11/18722 0.442756554322689 0.68234908666776 IRF2BP2 1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin 1/969 11/18722 0.442756554322689 0.68234908666776 CD46 1 GO:0003157 endocardium development 1/969 11/18722 0.442756554322689 0.68234908666776 RBPJ 1 GO:0006002 fructose 6-phosphate metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 TALDO1 1 GO:0006020 inositol metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 SLC5A3 1 GO:0006183 GTP biosynthetic process 1/969 11/18722 0.442756554322689 0.68234908666776 IMPDH2 1 GO:0006449 regulation of translational termination 1/969 11/18722 0.442756554322689 0.68234908666776 EIF5A 1 GO:0006527 arginine catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 ATP2B4 1 GO:0006705 mineralocorticoid biosynthetic process 1/969 11/18722 0.442756554322689 0.68234908666776 REST 1 GO:0007144 female meiosis I 1/969 11/18722 0.442756554322689 0.68234908666776 AURKA 1 GO:0009235 cobalamin metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 MTR 1 GO:0009313 oligosaccharide catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 MANBA 1 GO:0010269 response to selenium ion 1/969 11/18722 0.442756554322689 0.68234908666776 GPX1 1 GO:0010739 positive regulation of protein kinase A signaling 1/969 11/18722 0.442756554322689 0.68234908666776 MIF 1 GO:0010887 negative regulation of cholesterol storage 1/969 11/18722 0.442756554322689 0.68234908666776 ABCA1 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/969 11/18722 0.442756554322689 0.68234908666776 STOML2 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/969 11/18722 0.442756554322689 0.68234908666776 ANXA2 1 GO:0014010 Schwann cell proliferation 1/969 11/18722 0.442756554322689 0.68234908666776 DICER1 1 GO:0014854 response to inactivity 1/969 11/18722 0.442756554322689 0.68234908666776 DAG1 1 GO:0018026 peptidyl-lysine monomethylation 1/969 11/18722 0.442756554322689 0.68234908666776 SETD2 1 GO:0018342 protein prenylation 1/969 11/18722 0.442756554322689 0.68234908666776 CHML 1 GO:0021860 pyramidal neuron development 1/969 11/18722 0.442756554322689 0.68234908666776 UQCRQ 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/969 11/18722 0.442756554322689 0.68234908666776 CCNB1 1 GO:0032276 regulation of gonadotropin secretion 1/969 11/18722 0.442756554322689 0.68234908666776 GJA1 1 GO:0032341 aldosterone metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 REST 1 GO:0032351 negative regulation of hormone metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 REST 1 GO:0032377 regulation of intracellular lipid transport 1/969 11/18722 0.442756554322689 0.68234908666776 ANXA2 1 GO:0032610 interleukin-1 alpha production 1/969 11/18722 0.442756554322689 0.68234908666776 ISL1 1 GO:0032650 regulation of interleukin-1 alpha production 1/969 11/18722 0.442756554322689 0.68234908666776 ISL1 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/969 11/18722 0.442756554322689 0.68234908666776 PARP1 1 GO:0033197 response to vitamin E 1/969 11/18722 0.442756554322689 0.68234908666776 SRSF2 1 GO:0033234 negative regulation of protein sumoylation 1/969 11/18722 0.442756554322689 0.68234908666776 HMG20B 1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1/969 11/18722 0.442756554322689 0.68234908666776 ETFA 1 GO:0033625 positive regulation of integrin activation 1/969 11/18722 0.442756554322689 0.68234908666776 FERMT1 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/969 11/18722 0.442756554322689 0.68234908666776 WNK1 1 GO:0034163 regulation of toll-like receptor 9 signaling pathway 1/969 11/18722 0.442756554322689 0.68234908666776 RTN4 1 GO:0034770 histone H4-K20 methylation 1/969 11/18722 0.442756554322689 0.68234908666776 NSD1 1 GO:0034776 response to histamine 1/969 11/18722 0.442756554322689 0.68234908666776 DIAPH1 1 GO:0034969 histone arginine methylation 1/969 11/18722 0.442756554322689 0.68234908666776 PRMT1 1 GO:0035246 peptidyl-arginine N-methylation 1/969 11/18722 0.442756554322689 0.68234908666776 PRMT1 1 GO:0039530 MDA-5 signaling pathway 1/969 11/18722 0.442756554322689 0.68234908666776 ANKRD17 1 GO:0042167 heme catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 HMOX1 1 GO:0042447 hormone catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 CYP19A1 1 GO:0042789 mRNA transcription by RNA polymerase II 1/969 11/18722 0.442756554322689 0.68234908666776 SUPT6H 1 GO:0043312 neutrophil degranulation 1/969 11/18722 0.442756554322689 0.68234908666776 ANXA3 1 GO:0044068 modulation by symbiont of host cellular process 1/969 11/18722 0.442756554322689 0.68234908666776 SERPINB9 1 GO:0045060 negative thymic T cell selection 1/969 11/18722 0.442756554322689 0.68234908666776 GLI3 1 GO:0045628 regulation of T-helper 2 cell differentiation 1/969 11/18722 0.442756554322689 0.68234908666776 ANXA1 1 GO:0045793 positive regulation of cell size 1/969 11/18722 0.442756554322689 0.68234908666776 RB1CC1 1 GO:0045945 positive regulation of transcription by RNA polymerase III 1/969 11/18722 0.442756554322689 0.68234908666776 CHD8 1 GO:0046149 pigment catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 HMOX1 1 GO:0046598 positive regulation of viral entry into host cell 1/969 11/18722 0.442756554322689 0.68234908666776 P4HB 1 GO:0046643 regulation of gamma-delta T cell activation 1/969 11/18722 0.442756554322689 0.68234908666776 SOX4 1 GO:0046710 GDP metabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 DLG1 1 GO:0046929 negative regulation of neurotransmitter secretion 1/969 11/18722 0.442756554322689 0.68234908666776 PPP1R9A 1 GO:0046940 nucleoside monophosphate phosphorylation 1/969 11/18722 0.442756554322689 0.68234908666776 AK2 1 GO:0048102 autophagic cell death 1/969 11/18722 0.442756554322689 0.68234908666776 CTSV 1 GO:0048103 somatic stem cell division 1/969 11/18722 0.442756554322689 0.68234908666776 LBH 1 GO:0048853 forebrain morphogenesis 1/969 11/18722 0.442756554322689 0.68234908666776 NF1 1 GO:0051081 nuclear membrane disassembly 1/969 11/18722 0.442756554322689 0.68234908666776 NEK6 1 GO:0051610 serotonin uptake 1/969 11/18722 0.442756554322689 0.68234908666776 SLC6A4 1 GO:0060159 regulation of dopamine receptor signaling pathway 1/969 11/18722 0.442756554322689 0.68234908666776 CAV2 1 GO:0060174 limb bud formation 1/969 11/18722 0.442756554322689 0.68234908666776 SOX4 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/969 11/18722 0.442756554322689 0.68234908666776 GLI3 1 GO:0060581 cell fate commitment involved in pattern specification 1/969 11/18722 0.442756554322689 0.68234908666776 GLI3 1 GO:0060742 epithelial cell differentiation involved in prostate gland development 1/969 11/18722 0.442756554322689 0.68234908666776 PSAP 1 GO:0060746 parental behavior 1/969 11/18722 0.442756554322689 0.68234908666776 ZFX 1 GO:0060900 embryonic camera-type eye formation 1/969 11/18722 0.442756554322689 0.68234908666776 TFAP2A 1 GO:0061029 eyelid development in camera-type eye 1/969 11/18722 0.442756554322689 0.68234908666776 TFAP2A 1 GO:0070203 regulation of establishment of protein localization to telomere 1/969 11/18722 0.442756554322689 0.68234908666776 CCT8 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/969 11/18722 0.442756554322689 0.68234908666776 WNK1 1 GO:0070778 L-aspartate transmembrane transport 1/969 11/18722 0.442756554322689 0.68234908666776 SLC1A5 1 GO:0071044 histone mRNA catabolic process 1/969 11/18722 0.442756554322689 0.68234908666776 SSB 1 GO:0071492 cellular response to UV-A 1/969 11/18722 0.442756554322689 0.68234908666776 MME 1 GO:0071888 macrophage apoptotic process 1/969 11/18722 0.442756554322689 0.68234908666776 CTSL 1 GO:0072017 distal tubule development 1/969 11/18722 0.442756554322689 0.68234908666776 JAG1 1 GO:0072697 protein localization to cell cortex 1/969 11/18722 0.442756554322689 0.68234908666776 EZR 1 GO:0075294 positive regulation by symbiont of entry into host 1/969 11/18722 0.442756554322689 0.68234908666776 P4HB 1 GO:0086016 AV node cell action potential 1/969 11/18722 0.442756554322689 0.68234908666776 GJA5 1 GO:0086027 AV node cell to bundle of His cell signaling 1/969 11/18722 0.442756554322689 0.68234908666776 GJA5 1 GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/969 11/18722 0.442756554322689 0.68234908666776 GJA5 1 GO:0090030 regulation of steroid hormone biosynthetic process 1/969 11/18722 0.442756554322689 0.68234908666776 REST 1 GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly 1/969 11/18722 0.442756554322689 0.68234908666776 MPHOSPH8 1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/969 11/18722 0.442756554322689 0.68234908666776 SLC35B4 1 GO:0097354 prenylation 1/969 11/18722 0.442756554322689 0.68234908666776 CHML 1 GO:0097494 regulation of vesicle size 1/969 11/18722 0.442756554322689 0.68234908666776 RAB11A 1 GO:0099022 vesicle tethering 1/969 11/18722 0.442756554322689 0.68234908666776 TRIP11 1 GO:0106049 regulation of cellular response to osmotic stress 1/969 11/18722 0.442756554322689 0.68234908666776 EFHD1 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/969 11/18722 0.442756554322689 0.68234908666776 ATRX 1 GO:1900222 negative regulation of amyloid-beta clearance 1/969 11/18722 0.442756554322689 0.68234908666776 LRPAP1 1 GO:1900426 positive regulation of defense response to bacterium 1/969 11/18722 0.442756554322689 0.68234908666776 GRN 1 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1/969 11/18722 0.442756554322689 0.68234908666776 NMT1 1 GO:1902033 regulation of hematopoietic stem cell proliferation 1/969 11/18722 0.442756554322689 0.68234908666776 N4BP2L2 1 GO:1902065 response to L-glutamate 1/969 11/18722 0.442756554322689 0.68234908666776 UFL1 1 GO:1902337 regulation of apoptotic process involved in morphogenesis 1/969 11/18722 0.442756554322689 0.68234908666776 BMP7 1 GO:1903299 regulation of hexokinase activity 1/969 11/18722 0.442756554322689 0.68234908666776 RANBP2 1 GO:1904869 regulation of protein localization to Cajal body 1/969 11/18722 0.442756554322689 0.68234908666776 CCT8 1 GO:1904871 positive regulation of protein localization to Cajal body 1/969 11/18722 0.442756554322689 0.68234908666776 CCT8 1 GO:1905050 positive regulation of metallopeptidase activity 1/969 11/18722 0.442756554322689 0.68234908666776 CLDN4 1 GO:1905150 regulation of voltage-gated sodium channel activity 1/969 11/18722 0.442756554322689 0.68234908666776 KIF5B 1 GO:1905522 negative regulation of macrophage migration 1/969 11/18722 0.442756554322689 0.68234908666776 MIF 1 GO:1905668 positive regulation of protein localization to endosome 1/969 11/18722 0.442756554322689 0.68234908666776 EZR 1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production 1/969 11/18722 0.442756554322689 0.68234908666776 LRP1 1 GO:2000786 positive regulation of autophagosome assembly 1/969 11/18722 0.442756554322689 0.68234908666776 RAB3GAP2 1 GO:2001053 regulation of mesenchymal cell apoptotic process 1/969 11/18722 0.442756554322689 0.68234908666776 BMP7 1 GO:0032637 interleukin-8 production 6/969 103/18722 0.443560358614494 0.683386330813486 ANXA1/TMSB4X/HSPA1A/ANXA4/DDIT3/HSPA1B 6 GO:1903038 negative regulation of leukocyte cell-cell adhesion 8/969 141/18722 0.446859188688433 0.685345404559188 DLG5/ANXA1/DLG1/MIA3/GLI3/LGALS3/PAWR/WNK1 8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/969 29/18722 0.447061324941116 0.685345404559188 GPX1/MAPK14 2 GO:0003209 cardiac atrium morphogenesis 2/969 29/18722 0.447061324941116 0.685345404559188 SOX4/ISL1 2 GO:0005979 regulation of glycogen biosynthetic process 2/969 29/18722 0.447061324941116 0.685345404559188 IGF2/SORBS1 2 GO:0006734 NADH metabolic process 2/969 29/18722 0.447061324941116 0.685345404559188 ENO1/MDH2 2 GO:0010962 regulation of glucan biosynthetic process 2/969 29/18722 0.447061324941116 0.685345404559188 IGF2/SORBS1 2 GO:0015701 bicarbonate transport 2/969 29/18722 0.447061324941116 0.685345404559188 SLC26A2/CYB5R1 2 GO:0021591 ventricular system development 2/969 29/18722 0.447061324941116 0.685345404559188 SEMA6D/CDK6 2 GO:0033028 myeloid cell apoptotic process 2/969 29/18722 0.447061324941116 0.685345404559188 ANXA1/CTSL 2 GO:0048665 neuron fate specification 2/969 29/18722 0.447061324941116 0.685345404559188 ISL1/GLI3 2 GO:0051654 establishment of mitochondrion localization 2/969 29/18722 0.447061324941116 0.685345404559188 ARMCX3/UXT 2 GO:0062098 regulation of programmed necrotic cell death 2/969 29/18722 0.447061324941116 0.685345404559188 CAV1/CFLAR 2 GO:0070198 protein localization to chromosome, telomeric region 2/969 29/18722 0.447061324941116 0.685345404559188 ATRX/CCT8 2 GO:0095500 acetylcholine receptor signaling pathway 2/969 29/18722 0.447061324941116 0.685345404559188 LY6E/GNAQ 2 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 2/969 29/18722 0.447061324941116 0.685345404559188 CAV1/ANK3 2 GO:1902430 negative regulation of amyloid-beta formation 2/969 29/18722 0.447061324941116 0.685345404559188 ROCK1/RTN4 2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining 2/969 29/18722 0.447061324941116 0.685345404559188 PRKDC/RIF1 2 GO:0006303 double-strand break repair via nonhomologous end joining 4/969 66/18722 0.447673981930087 0.685882213300098 PRKDC/RIF1/KDM2A/UVRAG 4 GO:0071300 cellular response to retinoic acid 4/969 66/18722 0.447673981930087 0.685882213300098 ABCA1/SLC6A4/SETX/NDUFA13 4 GO:0043547 positive regulation of GTPase activity 14/969 255/18722 0.449396770667728 0.688319907241954 ITGA6/ITGB1/RASA1/S100A10/DOCK8/ADRB1/SYDE2/NF1/RABGAP1/PLXNB1/DOCK9/EVI5/SNX18/CAV2 14 GO:0010507 negative regulation of autophagy 5/969 85/18722 0.450870555983724 0.68997057849808 MET/EIF4G1/MCL1/SMG1/HMOX1 5 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 5/969 85/18722 0.450870555983724 0.68997057849808 CAV1/IL6ST/ISL1/CSH1/HES1 5 GO:0097006 regulation of plasma lipoprotein particle levels 5/969 85/18722 0.450870555983724 0.68997057849808 ANXA2/ABCA1/LRPAP1/MYLIP/HMOX1 5 GO:0032006 regulation of TOR signaling 6/969 104/18722 0.452794669455311 0.690380833931493 RICTOR/GNA12/WAC/ITFG2/PDCD6/SEC13 6 GO:0032963 collagen metabolic process 6/969 104/18722 0.452794669455311 0.690380833931493 ITGB1/SUCO/CTSL/MMP14/MMP15/SERPINH1 6 GO:0050729 positive regulation of inflammatory response 8/969 142/18722 0.45474927496316 0.690380833931493 NEAT1/EGFR/APP/GRN/IL6ST/CTSC/S100A9/NFKBIA 8 GO:0002673 regulation of acute inflammatory response 3/969 48/18722 0.455613645449425 0.690380833931493 ASH1L/IL6ST/GSTP1 3 GO:0045912 negative regulation of carbohydrate metabolic process 3/969 48/18722 0.455613645449425 0.690380833931493 CLTC/NCOR1/EP300 3 GO:0090199 regulation of release of cytochrome c from mitochondria 3/969 48/18722 0.455613645449425 0.690380833931493 GPX1/PMAIP1/GHITM 3 GO:0090311 regulation of protein deacetylation 3/969 48/18722 0.455613645449425 0.690380833931493 NIPBL/KDM5A/EP300 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/969 48/18722 0.455613645449425 0.690380833931493 CAV1/PMAIP1/PDIA3 3 GO:1902117 positive regulation of organelle assembly 4/969 67/18722 0.459238452789597 0.690380833931493 DYNC1H1/ATMIN/RHOA/RAB3GAP2 4 GO:1903317 regulation of protein maturation 4/969 67/18722 0.459238452789597 0.690380833931493 GLG1/ENO1/SOX4/MMP14 4 GO:0015908 fatty acid transport 5/969 86/18722 0.461050888812285 0.690380833931493 CROT/SLC2A1/ANXA1/PLIN2/SLC27A2 5 GO:1903510 mucopolysaccharide metabolic process 5/969 86/18722 0.461050888812285 0.690380833931493 ITIH5/CLTC/CHPF/GNS/B3GNT2 5 GO:2000117 negative regulation of cysteine-type endopeptidase activity 5/969 86/18722 0.461050888812285 0.690380833931493 SERPINB9/GPX1/USP47/DHCR24/SIAH2 5 GO:0030217 T cell differentiation 14/969 257/18722 0.461135701463764 0.690380833931493 CD46/RPS6/ZFP36L1/PRKDC/RPL22/SOX4/ANXA1/EGR1/CTSL/GLI3/RHOA/FOXP1/XBP1/GATA3 14 GO:0060759 regulation of response to cytokine stimulus 9/969 162/18722 0.462594467570221 0.690380833931493 CAV1/GSTP1/TRIM44/HSPA1A/ADAR/HSPA1B/CD24/TAF9/CASP4 9 GO:0006865 amino acid transport 8/969 143/18722 0.462619223163361 0.690380833931493 ITGB1/GJA1/SLC38A1/SLC38A2/SLC1A5/SLC38A10/SLC7A6/SLC3A2 8 GO:0062013 positive regulation of small molecule metabolic process 8/969 143/18722 0.462619223163361 0.690380833931493 APP/IGF2/ENO1/ANXA1/DDB1/TMSB4X/PMAIP1/SORBS1 8 GO:0042113 B cell activation 18/969 334/18722 0.464509740456352 0.690380833931493 MIF/ZFP36L1/ITGB1/SLC39A10/PRKDC/RIF1/TFRC/PIK3R1/MMP14/PAWR/YY1/EP300/XBP1/ITFG2/RBPJ/SUPT6H/IRF2BP2/TPD52 18 GO:0006884 cell volume homeostasis 2/969 30/18722 0.464619652351358 0.690380833931493 NPM1/KCNN4 2 GO:0007202 activation of phospholipase C activity 2/969 30/18722 0.464619652351358 0.690380833931493 EGFR/GNAQ 2 GO:0010453 regulation of cell fate commitment 2/969 30/18722 0.464619652351358 0.690380833931493 LMO4/HES1 2 GO:0017145 stem cell division 2/969 30/18722 0.464619652351358 0.690380833931493 NCOA3/LBH 2 GO:0019674 NAD metabolic process 2/969 30/18722 0.464619652351358 0.690380833931493 LDHA/ENO1 2 GO:0033137 negative regulation of peptidyl-serine phosphorylation 2/969 30/18722 0.464619652351358 0.690380833931493 CAV1/DMD 2 GO:0034694 response to prostaglandin 2/969 30/18722 0.464619652351358 0.690380833931493 TGFBR3/YY1 2 GO:0043032 positive regulation of macrophage activation 2/969 30/18722 0.464619652351358 0.690380833931493 JUND/CTSC 2 GO:0044030 regulation of DNA methylation 2/969 30/18722 0.464619652351358 0.690380833931493 PARP1/MPHOSPH8 2 GO:0051125 regulation of actin nucleation 2/969 30/18722 0.464619652351358 0.690380833931493 WASF2/SCIN 2 GO:0060351 cartilage development involved in endochondral bone morphogenesis 2/969 30/18722 0.464619652351358 0.690380833931493 TRIP11/SERPINH1 2 GO:0070168 negative regulation of biomineral tissue development 2/969 30/18722 0.464619652351358 0.690380833931493 ROCK1/LTBP3 2 GO:0070498 interleukin-1-mediated signaling pathway 2/969 30/18722 0.464619652351358 0.690380833931493 EGR1/RPS6KA5 2 GO:0090314 positive regulation of protein targeting to membrane 2/969 30/18722 0.464619652351358 0.690380833931493 TCAF1/ANK3 2 GO:0002764 immune response-regulating signaling pathway 25/969 468/18722 0.464685338024435 0.690380833931493 CAV1/SLC39A10/RPS3/LGR4/PUM1/PHPT1/HSPA1A/KCNN4/PDE4B/FOXP1/ANKRD17/PUM2/LGALS3/PAWR/COLEC12/WNK1/EP300/RTN4/NFKBIA/SPPL3/HSPA1B/GATA3/CD24/EZR/STOML2 25 GO:0097529 myeloid leukocyte migration 12/969 220/18722 0.468230609062894 0.690380833931493 CSF3R/MIF/ANXA1/DUSP1/PPIA/JAM3/S100A9/PDE4B/CD99/MMP14/LGALS3/DPP4 12 GO:0015711 organic anion transport 19/969 354/18722 0.468906010578049 0.690380833931493 LRP2/SLC26A2/ITGB1/SLC2A1/GJA1/ANXA1/SLC38A1/PSAP/SLC38A2/SLC16A12/SLC1A5/SLC52A3/SLC25A6/SLC7A6/SLC3A2/SLC35B4/SLC19A1/SLC13A3/CYB5R1 19 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3/969 49/18722 0.469201090171114 0.690380833931493 RIF1/TFRC/SUPT6H 3 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3/969 49/18722 0.469201090171114 0.690380833931493 RIF1/TFRC/SUPT6H 3 GO:0002762 negative regulation of myeloid leukocyte differentiation 3/969 49/18722 0.469201090171114 0.690380833931493 FBN1/CDK6/PIK3R1 3 GO:0008038 neuron recognition 3/969 49/18722 0.469201090171114 0.690380833931493 APP/NRP1/RTN4 3 GO:0030225 macrophage differentiation 3/969 49/18722 0.469201090171114 0.690380833931493 APP/PARP1/CDC42 3 GO:0042461 photoreceptor cell development 3/969 49/18722 0.469201090171114 0.690380833931493 TUG1/AHI1/NAGLU 3 GO:0045190 isotype switching 3/969 49/18722 0.469201090171114 0.690380833931493 RIF1/TFRC/SUPT6H 3 GO:0046605 regulation of centrosome cycle 3/969 49/18722 0.469201090171114 0.690380833931493 NPM1/XPO1/AURKA 3 GO:0048168 regulation of neuronal synaptic plasticity 3/969 49/18722 0.469201090171114 0.690380833931493 APP/RAB11A/KRAS 3 GO:0050832 defense response to fungus 3/969 49/18722 0.469201090171114 0.690380833931493 GAPDH/S100A9/COTL1 3 GO:0006633 fatty acid biosynthetic process 9/969 163/18722 0.469967437209682 0.690380833931493 MIF/ANXA1/ACSS1/GPX4/GSTP1/PTGES3/HACD3/XBP1/QKI 9 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 4/969 68/18722 0.470718751131879 0.690380833931493 IL6ST/ISL1/CSH1/HES1 4 GO:0042987 amyloid precursor protein catabolic process 4/969 68/18722 0.470718751131879 0.690380833931493 ROCK1/DHCR24/RTN4/FLOT2 4 GO:0046637 regulation of alpha-beta T cell differentiation 4/969 68/18722 0.470718751131879 0.690380833931493 ANXA1/GLI3/RHOA/GATA3 4 GO:0042116 macrophage activation 6/969 106/18722 0.471152852736996 0.690380833931493 JUND/APP/MIF/GRN/CTSC/FOXP1 6 GO:0001776 leukocyte homeostasis 5/969 87/18722 0.471175528501389 0.690380833931493 RPS6/ANXA1/JAM3/PMAIP1/PDE4B 5 GO:0044070 regulation of anion transport 5/969 87/18722 0.471175528501389 0.690380833931493 TCAF1/ITGB1/GABRE/AHCYL1/GOPC 5 GO:0000012 single strand break repair 1/969 12/18722 0.471614920997977 0.690380833931493 PARP1 1 GO:0002024 diet induced thermogenesis 1/969 12/18722 0.471614920997977 0.690380833931493 ADRB1 1 GO:0003207 cardiac chamber formation 1/969 12/18722 0.471614920997977 0.690380833931493 SOX4 1 GO:0003306 Wnt signaling pathway involved in heart development 1/969 12/18722 0.471614920997977 0.690380833931493 RBPJ 1 GO:0006534 cysteine metabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 GCLM 1 GO:0006703 estrogen biosynthetic process 1/969 12/18722 0.471614920997977 0.690380833931493 CYP19A1 1 GO:0006787 porphyrin-containing compound catabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 HMOX1 1 GO:0007320 insemination 1/969 12/18722 0.471614920997977 0.690380833931493 SLC6A4 1 GO:0008212 mineralocorticoid metabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 REST 1 GO:0009086 methionine biosynthetic process 1/969 12/18722 0.471614920997977 0.690380833931493 MTR 1 GO:0010454 negative regulation of cell fate commitment 1/969 12/18722 0.471614920997977 0.690380833931493 HES1 1 GO:0010459 negative regulation of heart rate 1/969 12/18722 0.471614920997977 0.690380833931493 SRI 1 GO:0010587 miRNA catabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 KCNQ1OT1 1 GO:0010623 programmed cell death involved in cell development 1/969 12/18722 0.471614920997977 0.690380833931493 PRKDC 1 GO:0010826 negative regulation of centrosome duplication 1/969 12/18722 0.471614920997977 0.690380833931493 NPM1 1 GO:0014889 muscle atrophy 1/969 12/18722 0.471614920997977 0.690380833931493 CFLAR 1 GO:0015780 nucleotide-sugar transmembrane transport 1/969 12/18722 0.471614920997977 0.690380833931493 SLC35B4 1 GO:0016554 cytidine to uridine editing 1/969 12/18722 0.471614920997977 0.690380833931493 RBM47 1 GO:0021527 spinal cord association neuron differentiation 1/969 12/18722 0.471614920997977 0.690380833931493 LMO4 1 GO:0021670 lateral ventricle development 1/969 12/18722 0.471614920997977 0.690380833931493 CDK6 1 GO:0021936 regulation of cerebellar granule cell precursor proliferation 1/969 12/18722 0.471614920997977 0.690380833931493 SLC6A4 1 GO:0030397 membrane disassembly 1/969 12/18722 0.471614920997977 0.690380833931493 NEK6 1 GO:0031953 negative regulation of protein autophosphorylation 1/969 12/18722 0.471614920997977 0.690380833931493 CAV1 1 GO:0032096 negative regulation of response to food 1/969 12/18722 0.471614920997977 0.690380833931493 NUCB2 1 GO:0032099 negative regulation of appetite 1/969 12/18722 0.471614920997977 0.690380833931493 NUCB2 1 GO:0032105 negative regulation of response to extracellular stimulus 1/969 12/18722 0.471614920997977 0.690380833931493 NUCB2 1 GO:0032108 negative regulation of response to nutrient levels 1/969 12/18722 0.471614920997977 0.690380833931493 NUCB2 1 GO:0032536 regulation of cell projection size 1/969 12/18722 0.471614920997977 0.690380833931493 EZR 1 GO:0032736 positive regulation of interleukin-13 production 1/969 12/18722 0.471614920997977 0.690380833931493 GATA3 1 GO:0032780 negative regulation of ATPase activity 1/969 12/18722 0.471614920997977 0.690380833931493 CNN3 1 GO:0032908 regulation of transforming growth factor beta1 production 1/969 12/18722 0.471614920997977 0.690380833931493 ATP6AP2 1 GO:0033004 negative regulation of mast cell activation 1/969 12/18722 0.471614920997977 0.690380833931493 HMOX1 1 GO:0033015 tetrapyrrole catabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 HMOX1 1 GO:0033182 regulation of histone ubiquitination 1/969 12/18722 0.471614920997977 0.690380833931493 UBR5 1 GO:0033523 histone H2B ubiquitination 1/969 12/18722 0.471614920997977 0.690380833931493 WAC 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/969 12/18722 0.471614920997977 0.690380833931493 CROT 1 GO:0035112 genitalia morphogenesis 1/969 12/18722 0.471614920997977 0.690380833931493 NIPBL 1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 1/969 12/18722 0.471614920997977 0.690380833931493 COL4A2 1 GO:0038180 nerve growth factor signaling pathway 1/969 12/18722 0.471614920997977 0.690380833931493 KIDINS220 1 GO:0038203 TORC2 signaling 1/969 12/18722 0.471614920997977 0.690380833931493 RICTOR 1 GO:0042117 monocyte activation 1/969 12/18722 0.471614920997977 0.690380833931493 FOXP1 1 GO:0043129 surfactant homeostasis 1/969 12/18722 0.471614920997977 0.690380833931493 EPAS1 1 GO:0043248 proteasome assembly 1/969 12/18722 0.471614920997977 0.690380833931493 POMP 1 GO:0043301 negative regulation of leukocyte degranulation 1/969 12/18722 0.471614920997977 0.690380833931493 HMOX1 1 GO:0043380 regulation of memory T cell differentiation 1/969 12/18722 0.471614920997977 0.690380833931493 CD46 1 GO:0043383 negative T cell selection 1/969 12/18722 0.471614920997977 0.690380833931493 GLI3 1 GO:0043471 regulation of cellular carbohydrate catabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 PGAM1 1 GO:0043476 pigment accumulation 1/969 12/18722 0.471614920997977 0.690380833931493 CD63 1 GO:0043482 cellular pigment accumulation 1/969 12/18722 0.471614920997977 0.690380833931493 CD63 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/969 12/18722 0.471614920997977 0.690380833931493 PHIP 1 GO:0045039 protein insertion into mitochondrial inner membrane 1/969 12/18722 0.471614920997977 0.690380833931493 NDUFA13 1 GO:0045117 azole transmembrane transport 1/969 12/18722 0.471614920997977 0.690380833931493 SLC19A3 1 GO:0045916 negative regulation of complement activation 1/969 12/18722 0.471614920997977 0.690380833931493 CD46 1 GO:0046541 saliva secretion 1/969 12/18722 0.471614920997977 0.690380833931493 KCNN4 1 GO:0046606 negative regulation of centrosome cycle 1/969 12/18722 0.471614920997977 0.690380833931493 NPM1 1 GO:0048934 peripheral nervous system neuron differentiation 1/969 12/18722 0.471614920997977 0.690380833931493 ISL1 1 GO:0048935 peripheral nervous system neuron development 1/969 12/18722 0.471614920997977 0.690380833931493 ISL1 1 GO:0060009 Sertoli cell development 1/969 12/18722 0.471614920997977 0.690380833931493 ATRX 1 GO:0060134 prepulse inhibition 1/969 12/18722 0.471614920997977 0.690380833931493 CHD8 1 GO:0060221 retinal rod cell differentiation 1/969 12/18722 0.471614920997977 0.690380833931493 NAGLU 1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1/969 12/18722 0.471614920997977 0.690380833931493 LRP1 1 GO:0060442 branching involved in prostate gland morphogenesis 1/969 12/18722 0.471614920997977 0.690380833931493 BMP7 1 GO:0060601 lateral sprouting from an epithelium 1/969 12/18722 0.471614920997977 0.690380833931493 BMP7 1 GO:0060788 ectodermal placode formation 1/969 12/18722 0.471614920997977 0.690380833931493 TBX3 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/969 12/18722 0.471614920997977 0.690380833931493 GLI3 1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 1/969 12/18722 0.471614920997977 0.690380833931493 DDX39B 1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development 1/969 12/18722 0.471614920997977 0.690380833931493 YY1 1 GO:0061620 glycolytic process through glucose-6-phosphate 1/969 12/18722 0.471614920997977 0.690380833931493 ENO1 1 GO:0070170 regulation of tooth mineralization 1/969 12/18722 0.471614920997977 0.690380833931493 TFAP2A 1 GO:0070202 regulation of establishment of protein localization to chromosome 1/969 12/18722 0.471614920997977 0.690380833931493 CCT8 1 GO:0070213 protein auto-ADP-ribosylation 1/969 12/18722 0.471614920997977 0.690380833931493 PARP1 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/969 12/18722 0.471614920997977 0.690380833931493 WNK1 1 GO:0071107 response to parathyroid hormone 1/969 12/18722 0.471614920997977 0.690380833931493 GJA1 1 GO:0071468 cellular response to acidic pH 1/969 12/18722 0.471614920997977 0.690380833931493 SLC9A1 1 GO:0071635 negative regulation of transforming growth factor beta production 1/969 12/18722 0.471614920997977 0.690380833931493 CD24 1 GO:0071697 ectodermal placode morphogenesis 1/969 12/18722 0.471614920997977 0.690380833931493 TBX3 1 GO:0072376 protein activation cascade 1/969 12/18722 0.471614920997977 0.690380833931493 FBLN1 1 GO:0072537 fibroblast activation 1/969 12/18722 0.471614920997977 0.690380833931493 GCLM 1 GO:0072584 caveolin-mediated endocytosis 1/969 12/18722 0.471614920997977 0.690380833931493 CAV1 1 GO:0072683 T cell extravasation 1/969 12/18722 0.471614920997977 0.690380833931493 CD99 1 GO:0072711 cellular response to hydroxyurea 1/969 12/18722 0.471614920997977 0.690380833931493 ATRX 1 GO:0086067 AV node cell to bundle of His cell communication 1/969 12/18722 0.471614920997977 0.690380833931493 GJA5 1 GO:0090385 phagosome-lysosome fusion 1/969 12/18722 0.471614920997977 0.690380833931493 SYT7 1 GO:0097152 mesenchymal cell apoptotic process 1/969 12/18722 0.471614920997977 0.690380833931493 BMP7 1 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/969 12/18722 0.471614920997977 0.690380833931493 MIA3 1 GO:0150065 regulation of deacetylase activity 1/969 12/18722 0.471614920997977 0.690380833931493 KDM5A 1 GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity 1/969 12/18722 0.471614920997977 0.690380833931493 C4orf3 1 GO:1902563 regulation of neutrophil activation 1/969 12/18722 0.471614920997977 0.690380833931493 GRN 1 GO:1902950 regulation of dendritic spine maintenance 1/969 12/18722 0.471614920997977 0.690380833931493 HOMER1 1 GO:1903405 protein localization to nuclear body 1/969 12/18722 0.471614920997977 0.690380833931493 CCT8 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/969 12/18722 0.471614920997977 0.690380833931493 VDAC1 1 GO:1904748 regulation of apoptotic process involved in development 1/969 12/18722 0.471614920997977 0.690380833931493 BMP7 1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 1/969 12/18722 0.471614920997977 0.690380833931493 CCT8 1 GO:1904867 protein localization to Cajal body 1/969 12/18722 0.471614920997977 0.690380833931493 CCT8 1 GO:1905205 positive regulation of connective tissue replacement 1/969 12/18722 0.471614920997977 0.690380833931493 ROCK1 1 GO:1905214 regulation of RNA binding 1/969 12/18722 0.471614920997977 0.690380833931493 EIF4G1 1 GO:1905245 regulation of aspartic-type peptidase activity 1/969 12/18722 0.471614920997977 0.690380833931493 GRN 1 GO:1905666 regulation of protein localization to endosome 1/969 12/18722 0.471614920997977 0.690380833931493 EZR 1 GO:1905709 negative regulation of membrane permeability 1/969 12/18722 0.471614920997977 0.690380833931493 DYNLT1 1 GO:2000009 negative regulation of protein localization to cell surface 1/969 12/18722 0.471614920997977 0.690380833931493 GOPC 1 GO:2000303 regulation of ceramide biosynthetic process 1/969 12/18722 0.471614920997977 0.690380833931493 ORMDL1 1 GO:2000628 regulation of miRNA metabolic process 1/969 12/18722 0.471614920997977 0.690380833931493 KCNQ1OT1 1 GO:2001204 regulation of osteoclast development 1/969 12/18722 0.471614920997977 0.690380833931493 FBN1 1 GO:0050851 antigen receptor-mediated signaling pathway 13/969 240/18722 0.473693745692021 0.693229771768832 SLC39A10/RPS3/PHPT1/KCNN4/PDE4B/FOXP1/LGALS3/PAWR/WNK1/SPPL3/GATA3/EZR/STOML2 13 GO:0019722 calcium-mediated signaling 11/969 202/18722 0.475457418997378 0.695616033505123 EGFR/NFAT5/GSTO1/PPP1R9A/ATP2B4/MCTP2/SLC9A1/DMD/CALM1/SPPL3/CALM2 11 GO:0006813 potassium ion transport 13/969 241/18722 0.479760420103489 0.700832919720032 AKAP9/CAV1/ITGB1/CD63/ANK3/DLG1/KIF5B/KCNN4/SLC9A1/WNK1/GJA5/VAMP2/YWHAE 13 GO:0071868 cellular response to monoamine stimulus 6/969 107/18722 0.480268272971664 0.700832919720032 APP/ATP2B4/PDE4B/SLC9A1/ID1/CAV2 6 GO:0071870 cellular response to catecholamine stimulus 6/969 107/18722 0.480268272971664 0.700832919720032 APP/ATP2B4/PDE4B/SLC9A1/ID1/CAV2 6 GO:0007260 tyrosine phosphorylation of STAT protein 5/969 88/18722 0.481239107652757 0.700832919720032 CAV1/IL6ST/ISL1/CSH1/HES1 5 GO:0002230 positive regulation of defense response to virus by host 2/969 31/18722 0.481843765562976 0.700832919720032 TRIM44/EIF2AK4 2 GO:0002828 regulation of type 2 immune response 2/969 31/18722 0.481843765562976 0.700832919720032 ANXA1/GATA3 2 GO:0006301 postreplication repair 2/969 31/18722 0.481843765562976 0.700832919720032 USP10/UBE2A 2 GO:0008045 motor neuron axon guidance 2/969 31/18722 0.481843765562976 0.700832919720032 MYCBP2/NRP1 2 GO:0030212 hyaluronan metabolic process 2/969 31/18722 0.481843765562976 0.700832919720032 ITIH5/CLTC 2 GO:0031063 regulation of histone deacetylation 2/969 31/18722 0.481843765562976 0.700832919720032 NIPBL/KDM5A 2 GO:0031114 regulation of microtubule depolymerization 2/969 31/18722 0.481843765562976 0.700832919720032 CAMSAP2/TAOK1 2 GO:0032148 activation of protein kinase B activity 2/969 31/18722 0.481843765562976 0.700832919720032 PPIA/TXN 2 GO:0043171 peptide catabolic process 2/969 31/18722 0.481843765562976 0.700832919720032 ENPEP/NPEPPS 2 GO:0048566 embryonic digestive tract development 2/969 31/18722 0.481843765562976 0.700832919720032 NIPBL/GLI3 2 GO:0048710 regulation of astrocyte differentiation 2/969 31/18722 0.481843765562976 0.700832919720032 IL6ST/HES1 2 GO:0051569 regulation of histone H3-K4 methylation 2/969 31/18722 0.481843765562976 0.700832919720032 RTF1/GATA3 2 GO:0070633 transepithelial transport 2/969 31/18722 0.481843765562976 0.700832919720032 ACTG1/AHCYL1 2 GO:0070723 response to cholesterol 2/969 31/18722 0.481843765562976 0.700832919720032 DAG1/ABCA1 2 GO:0071168 protein localization to chromatin 2/969 31/18722 0.481843765562976 0.700832919720032 NIPBL/SETD2 2 GO:0110150 negative regulation of biomineralization 2/969 31/18722 0.481843765562976 0.700832919720032 ROCK1/LTBP3 2 GO:0003143 embryonic heart tube morphogenesis 4/969 69/18722 0.482107605509666 0.700832919720032 TBX3/AHI1/CITED2/HES1 4 GO:0050688 regulation of defense response to virus 4/969 69/18722 0.482107605509666 0.700832919720032 TRIM44/EIF2AK4/PCBP2/HTRA1 4 GO:0050810 regulation of steroid biosynthetic process 4/969 69/18722 0.482107605509666 0.700832919720032 SF1/EGR1/MBTPS1/REST 4 GO:0002639 positive regulation of immunoglobulin production 3/969 50/18722 0.482633901114051 0.701012998116184 RIF1/TFRC/XBP1 3 GO:0043628 ncRNA 3'-end processing 3/969 50/18722 0.482633901114051 0.701012998116184 RPS21/INTS6/SSB 3 GO:0046638 positive regulation of alpha-beta T cell differentiation 3/969 50/18722 0.482633901114051 0.701012998116184 ANXA1/GLI3/RHOA 3 GO:0002274 myeloid leukocyte activation 12/969 223/18722 0.487189100821754 0.704204898912039 JUND/APP/MIF/GRN/DHRS2/CTSC/ITGB8/FOXP1/RBPJ/VAMP2/HMOX1/ANXA3 12 GO:0051224 negative regulation of protein transport 7/969 127/18722 0.487632056209178 0.704204898912039 LMAN1/ANXA1/FRMD4A/FERMT1/TXN/REST/GOPC 7 GO:0098659 inorganic cation import across plasma membrane 6/969 108/18722 0.489335848447962 0.704204898912039 SLC39A10/DLG1/ATP2B4/SLC9A1/TRPV6/WNK1 6 GO:0099587 inorganic ion import across plasma membrane 6/969 108/18722 0.489335848447962 0.704204898912039 SLC39A10/DLG1/ATP2B4/SLC9A1/TRPV6/WNK1 6 GO:0006790 sulfur compound metabolic process 18/969 339/18722 0.490193879937033 0.704204898912039 SLC26A2/CLIC3/GSTO1/ACSS1/GPX4/GSTP1/GPX1/CHPF/MTR/GNS/SLC19A3/CLIC1/TPST2/AHCYL1/IDH1/B3GNT2/GCLM/GSTA3 18 GO:0018212 peptidyl-tyrosine modification 20/969 378/18722 0.492505224543667 0.704204898912039 EGFR/CAV1/APP/MIF/MET/IQGAP1/IGF2/EPHB4/IL6ST/ISL1/NRP1/IGF1R/BAZ1B/PRLR/EFEMP1/RICTOR/CSH1/TPST2/CD24/HES1 20 GO:0045123 cellular extravasation 4/969 70/18722 0.493398159048188 0.704204898912039 ITGB1/ROCK1/JAM3/CD99 4 GO:0006636 unsaturated fatty acid biosynthetic process 3/969 51/18722 0.495902506878233 0.704204898912039 MIF/ANXA1/PTGES3 3 GO:0045668 negative regulation of osteoblast differentiation 3/969 51/18722 0.495902506878233 0.704204898912039 CRIM1/CDK6/LRP5 3 GO:0048013 ephrin receptor signaling pathway 3/969 51/18722 0.495902506878233 0.704204898912039 EPHB4/RASA1/RBPJ 3 GO:0065002 intracellular protein transmembrane transport 3/969 51/18722 0.495902506878233 0.704204898912039 HSPA5/SEC62/DNAJC15 3 GO:0006869 lipid transport 21/969 398/18722 0.495931477152557 0.704204898912039 LRP1/CAV1/ITGAV/CROT/SLC2A1/ANXA1/PLIN2/ANXA2/PSAP/CYP19A1/SLC27A2/KDM5B/KCNN4/SYT7/ABCA1/ATP10D/NFKBIA/RXRA/TMF1/OSBPL9/NPC2 21 GO:1902115 regulation of organelle assembly 10/969 186/18722 0.497134935330553 0.704204898912039 DYNC1H1/NPM1/TPR/HSPA1A/ATMIN/RHOA/RAB3GAP2/HSPA1B/EZR/HNRNPU 10 GO:0006821 chloride transport 6/969 109/18722 0.498351711688529 0.704204898912039 SLC26A2/CLIC3/GABRE/CLDN4/CLIC1/PCYOX1 6 GO:0006026 aminoglycan catabolic process 2/969 32/18722 0.498721203294942 0.704204898912039 GNS/NAGLU 2 GO:0008156 negative regulation of DNA replication 2/969 32/18722 0.498721203294942 0.704204898912039 S100A11/PDS5A 2 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 2/969 32/18722 0.498721203294942 0.704204898912039 PPP1R10/CFLAR 2 GO:0030431 sleep 2/969 32/18722 0.498721203294942 0.704204898912039 FOS/ADRB1 2 GO:0035883 enteroendocrine cell differentiation 2/969 32/18722 0.498721203294942 0.704204898912039 CDK6/HES1 2 GO:0045684 positive regulation of epidermis development 2/969 32/18722 0.498721203294942 0.704204898912039 NCOA3/KRT10 2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 2/969 32/18722 0.498721203294942 0.704204898912039 NR2F2/LATS2 2 GO:0050850 positive regulation of calcium-mediated signaling 2/969 32/18722 0.498721203294942 0.704204898912039 SLC9A1/SPPL3 2 GO:0061037 negative regulation of cartilage development 2/969 32/18722 0.498721203294942 0.704204898912039 EFEMP1/LTBP3 2 GO:0090022 regulation of neutrophil chemotaxis 2/969 32/18722 0.498721203294942 0.704204898912039 JAM3/DPP4 2 GO:1901185 negative regulation of ERBB signaling pathway 2/969 32/18722 0.498721203294942 0.704204898912039 EGFR/PTPN12 2 GO:0001682 tRNA 5'-leader removal 1/969 13/18722 0.498980241230631 0.704204898912039 SSB 1 GO:0001886 endothelial cell morphogenesis 1/969 13/18722 0.498980241230631 0.704204898912039 MET 1 GO:0002638 negative regulation of immunoglobulin production 1/969 13/18722 0.498980241230631 0.704204898912039 PRKDC 1 GO:0003222 ventricular trabecula myocardium morphogenesis 1/969 13/18722 0.498980241230631 0.704204898912039 RBPJ 1 GO:0006264 mitochondrial DNA replication 1/969 13/18722 0.498980241230631 0.704204898912039 STOML2 1 GO:0006361 transcription initiation from RNA polymerase I promoter 1/969 13/18722 0.498980241230631 0.704204898912039 BAZ2A 1 GO:0007183 SMAD protein complex assembly 1/969 13/18722 0.498980241230631 0.704204898912039 PARP1 1 GO:0007494 midgut development 1/969 13/18722 0.498980241230631 0.704204898912039 EGFR 1 GO:0007567 parturition 1/969 13/18722 0.498980241230631 0.704204898912039 HPGD 1 GO:0008298 intracellular mRNA localization 1/969 13/18722 0.498980241230631 0.704204898912039 ZFP36L1 1 GO:0009437 carnitine metabolic process 1/969 13/18722 0.498980241230631 0.704204898912039 CROT 1 GO:0009650 UV protection 1/969 13/18722 0.498980241230631 0.704204898912039 GPX1 1 GO:0010755 regulation of plasminogen activation 1/969 13/18722 0.498980241230631 0.704204898912039 ENO1 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/969 13/18722 0.498980241230631 0.704204898912039 PMAIP1 1 GO:0010958 regulation of amino acid import across plasma membrane 1/969 13/18722 0.498980241230631 0.704204898912039 ITGB1 1 GO:0014029 neural crest formation 1/969 13/18722 0.498980241230631 0.704204898912039 PDCD6 1 GO:0014745 negative regulation of muscle adaptation 1/969 13/18722 0.498980241230631 0.704204898912039 ATP2B4 1 GO:0015791 polyol transport 1/969 13/18722 0.498980241230631 0.704204898912039 SLC5A3 1 GO:0015801 aromatic amino acid transport 1/969 13/18722 0.498980241230631 0.704204898912039 SLC3A2 1 GO:0016056 rhodopsin mediated signaling pathway 1/969 13/18722 0.498980241230631 0.704204898912039 NMT1 1 GO:0016078 tRNA catabolic process 1/969 13/18722 0.498980241230631 0.704204898912039 DICER1 1 GO:0016322 neuron remodeling 1/969 13/18722 0.498980241230631 0.704204898912039 APP 1 GO:0021794 thalamus development 1/969 13/18722 0.498980241230631 0.704204898912039 UQCRQ 1 GO:0021859 pyramidal neuron differentiation 1/969 13/18722 0.498980241230631 0.704204898912039 UQCRQ 1 GO:0021984 adenohypophysis development 1/969 13/18722 0.498980241230631 0.704204898912039 HES1 1 GO:0030497 fatty acid elongation 1/969 13/18722 0.498980241230631 0.704204898912039 HACD3 1 GO:0031272 regulation of pseudopodium assembly 1/969 13/18722 0.498980241230631 0.704204898912039 CDC42 1 GO:0031274 positive regulation of pseudopodium assembly 1/969 13/18722 0.498980241230631 0.704204898912039 CDC42 1 GO:0031392 regulation of prostaglandin biosynthetic process 1/969 13/18722 0.498980241230631 0.704204898912039 ANXA1 1 GO:0032042 mitochondrial DNA metabolic process 1/969 13/18722 0.498980241230631 0.704204898912039 PARP1 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/969 13/18722 0.498980241230631 0.704204898912039 KIF5B 1 GO:0032252 secretory granule localization 1/969 13/18722 0.498980241230631 0.704204898912039 KIF5B 1 GO:0032905 transforming growth factor beta1 production 1/969 13/18722 0.498980241230631 0.704204898912039 ATP6AP2 1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 1/969 13/18722 0.498980241230631 0.704204898912039 PARP1 1 GO:0033262 regulation of nuclear cell cycle DNA replication 1/969 13/18722 0.498980241230631 0.704204898912039 ATRX 1 GO:0033689 negative regulation of osteoblast proliferation 1/969 13/18722 0.498980241230631 0.704204898912039 PLXNB1 1 GO:0033700 phospholipid efflux 1/969 13/18722 0.498980241230631 0.704204898912039 ABCA1 1 GO:0034309 primary alcohol biosynthetic process 1/969 13/18722 0.498980241230631 0.704204898912039 REST 1 GO:0035745 T-helper 2 cell cytokine production 1/969 13/18722 0.498980241230631 0.704204898912039 GATA3 1 GO:0035845 photoreceptor cell outer segment organization 1/969 13/18722 0.498980241230631 0.704204898912039 AHI1 1 GO:0042308 negative regulation of protein import into nucleus 1/969 13/18722 0.498980241230631 0.704204898912039 FERMT1 1 GO:0042492 gamma-delta T cell differentiation 1/969 13/18722 0.498980241230631 0.704204898912039 SOX4 1 GO:0042541 hemoglobin biosynthetic process 1/969 13/18722 0.498980241230631 0.704204898912039 PRMT1 1 GO:0042659 regulation of cell fate specification 1/969 13/18722 0.498980241230631 0.704204898912039 LMO4 1 GO:0042761 very long-chain fatty acid biosynthetic process 1/969 13/18722 0.498980241230631 0.704204898912039 HACD3 1 GO:0043247 telomere maintenance in response to DNA damage 1/969 13/18722 0.498980241230631 0.704204898912039 RIF1 1 GO:0043379 memory T cell differentiation 1/969 13/18722 0.498980241230631 0.704204898912039 CD46 1 GO:0048207 vesicle targeting, rough ER to cis-Golgi 1/969 13/18722 0.498980241230631 0.704204898912039 PDCD6 1 GO:0048208 COPII vesicle coating 1/969 13/18722 0.498980241230631 0.704204898912039 PDCD6 1 GO:0048266 behavioral response to pain 1/969 13/18722 0.498980241230631 0.704204898912039 VWA1 1 GO:0051709 regulation of killing of cells of other organism 1/969 13/18722 0.498980241230631 0.704204898912039 SERPINB9 1 GO:0060670 branching involved in labyrinthine layer morphogenesis 1/969 13/18722 0.498980241230631 0.704204898912039 SPINT1 1 GO:0061615 glycolytic process through fructose-6-phosphate 1/969 13/18722 0.498980241230631 0.704204898912039 ENO1 1 GO:0061744 motor behavior 1/969 13/18722 0.498980241230631 0.704204898912039 DPP4 1 GO:0070254 mucus secretion 1/969 13/18722 0.498980241230631 0.704204898912039 EGFR 1 GO:0071801 regulation of podosome assembly 1/969 13/18722 0.498980241230631 0.704204898912039 RHOA 1 GO:0072672 neutrophil extravasation 1/969 13/18722 0.498980241230631 0.704204898912039 CD99 1 GO:0072710 response to hydroxyurea 1/969 13/18722 0.498980241230631 0.704204898912039 ATRX 1 GO:0090042 tubulin deacetylation 1/969 13/18722 0.498980241230631 0.704204898912039 EP300 1 GO:0090153 regulation of sphingolipid biosynthetic process 1/969 13/18722 0.498980241230631 0.704204898912039 ORMDL1 1 GO:0090158 endoplasmic reticulum membrane organization 1/969 13/18722 0.498980241230631 0.704204898912039 RTN4 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/969 13/18722 0.498980241230631 0.704204898912039 IARS2 1 GO:0110096 cellular response to aldehyde 1/969 13/18722 0.498980241230631 0.704204898912039 AKR1B1 1 GO:1900044 regulation of protein K63-linked ubiquitination 1/969 13/18722 0.498980241230631 0.704204898912039 UBR5 1 GO:1900121 negative regulation of receptor binding 1/969 13/18722 0.498980241230631 0.704204898912039 PTPRF 1 GO:1900452 regulation of long-term synaptic depression 1/969 13/18722 0.498980241230631 0.704204898912039 PPP1R9A 1 GO:1901096 regulation of autophagosome maturation 1/969 13/18722 0.498980241230631 0.704204898912039 UVRAG 1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/969 13/18722 0.498980241230631 0.704204898912039 PMAIP1 1 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1/969 13/18722 0.498980241230631 0.704204898912039 ANK3 1 GO:1902947 regulation of tau-protein kinase activity 1/969 13/18722 0.498980241230631 0.704204898912039 EGR1 1 GO:1903054 negative regulation of extracellular matrix organization 1/969 13/18722 0.498980241230631 0.704204898912039 DPP4 1 GO:1903651 positive regulation of cytoplasmic transport 1/969 13/18722 0.498980241230631 0.704204898912039 EZR 1 GO:1903789 regulation of amino acid transmembrane transport 1/969 13/18722 0.498980241230631 0.704204898912039 ITGB1 1 GO:1903977 positive regulation of glial cell migration 1/969 13/18722 0.498980241230631 0.704204898912039 LRP1 1 GO:1904590 negative regulation of protein import 1/969 13/18722 0.498980241230631 0.704204898912039 FERMT1 1 GO:1905038 regulation of membrane lipid metabolic process 1/969 13/18722 0.498980241230631 0.704204898912039 ORMDL1 1 GO:1905203 regulation of connective tissue replacement 1/969 13/18722 0.498980241230631 0.704204898912039 ROCK1 1 GO:1905939 regulation of gonad development 1/969 13/18722 0.498980241230631 0.704204898912039 CITED2 1 GO:2000551 regulation of T-helper 2 cell cytokine production 1/969 13/18722 0.498980241230631 0.704204898912039 GATA3 1 GO:2001023 regulation of response to drug 1/969 13/18722 0.498980241230631 0.704204898912039 ADIRF 1 GO:0055088 lipid homeostasis 9/969 167/18722 0.499231607105167 0.704369432702916 CAV1/ORMDL1/LRP5/ABCA1/XBP1/RTN4/MYLIP/CD24/NPC2 9 GO:0099175 regulation of postsynapse organization 5/969 90/18722 0.501162771522672 0.706903277726716 NRP2/CFL1/PPP1R9A/HOMER1/ARF4 5 GO:0008344 adult locomotory behavior 4/969 71/18722 0.504583963964077 0.71134496781124 APP/PUM1/EPS8/CSTB 4 GO:0032722 positive regulation of chemokine production 4/969 71/18722 0.504583963964077 0.71134496781124 LRP1/APP/EGR1/HMOX1 4 GO:0015850 organic hydroxy compound transport 15/969 284/18722 0.505705695509894 0.712734078946793 LRP1/CAV1/ANXA2/CYP19A1/LY6E/KDM5B/SYT7/SLC5A3/ABCA1/SLC6A4/NFKBIA/RXRA/TMF1/OSBPL9/NPC2 15 GO:0050804 modulation of chemical synaptic transmission 23/969 439/18722 0.506810681864331 0.714098846973037 EGFR/AKAP9/CDH1/APP/ITGB1/RPL22/PPP1R9A/ERC1/KIF5B/PTPRA/SYT7/RAB11A/MCTP2/CALM1/SLC6A4/EIF2AK4/CLSTN1/MME/HOMER1/USP8/VAMP2/KRAS/CDC20 23 GO:0003014 renal system process 6/969 110/18722 0.507312140759694 0.714612735204895 GJA1/CLDN4/RHOA/AKR1B1/GJA5/MAGED2 6 GO:0051607 defense response to virus 14/969 265/18722 0.507715293908555 0.714795292555525 DDX17/PUM1/TRIM44/NCBP3/PMAIP1/SETD2/EXOC1/ANKRD17/PUM2/TRIM56/ADAR/EIF2AK4/PCBP2/HTRA1 14 GO:0140546 defense response to symbiont 14/969 265/18722 0.507715293908555 0.714795292555525 DDX17/PUM1/TRIM44/NCBP3/PMAIP1/SETD2/EXOC1/ANKRD17/PUM2/TRIM56/ADAR/EIF2AK4/PCBP2/HTRA1 14 GO:0002218 activation of innate immune response 3/969 52/18722 0.508998177363397 0.715060342715352 PRKDC/EP300/SFPQ 3 GO:0010662 regulation of striated muscle cell apoptotic process 3/969 52/18722 0.508998177363397 0.715060342715352 PPP1R10/BMP7/CFLAR 3 GO:0034204 lipid translocation 3/969 52/18722 0.508998177363397 0.715060342715352 KCNN4/ABCA1/ATP10D 3 GO:0043090 amino acid import 3/969 52/18722 0.508998177363397 0.715060342715352 ITGB1/SLC1A5/SLC3A2 3 GO:0043277 apoptotic cell clearance 3/969 52/18722 0.508998177363397 0.715060342715352 LRP1/ITGAV/ANXA1 3 GO:0048260 positive regulation of receptor-mediated endocytosis 3/969 52/18722 0.508998177363397 0.715060342715352 CD63/ANXA2/AHI1 3 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 3/969 52/18722 0.508998177363397 0.715060342715352 ZNRF3/RHOA/CDC42 3 GO:1903426 regulation of reactive oxygen species biosynthetic process 3/969 52/18722 0.508998177363397 0.715060342715352 SLC5A3/RHOA/CFLAR 3 GO:0002065 columnar/cuboidal epithelial cell differentiation 5/969 91/18722 0.511013277800713 0.717505478180152 SOX4/CDK6/IL6ST/KLF5/HES1 5 GO:0006885 regulation of pH 5/969 91/18722 0.511013277800713 0.717505478180152 GRN/SLC9A1/ATP6V0E1/TM9SF4/ATP6AP2 5 GO:0099177 regulation of trans-synaptic signaling 23/969 440/18722 0.511309372989458 0.717728386581496 EGFR/AKAP9/CDH1/APP/ITGB1/RPL22/PPP1R9A/ERC1/KIF5B/PTPRA/SYT7/RAB11A/MCTP2/CALM1/SLC6A4/EIF2AK4/CLSTN1/MME/HOMER1/USP8/VAMP2/KRAS/CDC20 23 GO:0009152 purine ribonucleotide biosynthetic process 9/969 169/18722 0.513696517779516 0.718807541777006 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0001881 receptor recycling 2/969 33/18722 0.515241686088148 0.718807541777006 ANXA2/VAMP3 2 GO:0001975 response to amphetamine 2/969 33/18722 0.515241686088148 0.718807541777006 RANBP2/CALM1 2 GO:0002335 mature B cell differentiation 2/969 33/18722 0.515241686088148 0.718807541777006 XBP1/ITFG2 2 GO:0010259 multicellular organism aging 2/969 33/18722 0.515241686088148 0.718807541777006 CTSV/TFCP2L1 2 GO:0010737 protein kinase A signaling 2/969 33/18722 0.515241686088148 0.718807541777006 MIF/EZR 2 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 2/969 33/18722 0.515241686088148 0.718807541777006 EPN2/PDCD6 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/969 33/18722 0.515241686088148 0.718807541777006 KIF5B/KRAS 2 GO:0032633 interleukin-4 production 2/969 33/18722 0.515241686088148 0.718807541777006 DDIT3/GATA3 2 GO:0032673 regulation of interleukin-4 production 2/969 33/18722 0.515241686088148 0.718807541777006 DDIT3/GATA3 2 GO:0034110 regulation of homotypic cell-cell adhesion 2/969 33/18722 0.515241686088148 0.718807541777006 IL6ST/ANK3 2 GO:0035025 positive regulation of Rho protein signal transduction 2/969 33/18722 0.515241686088148 0.718807541777006 ADGRG1/AKAP13 2 GO:0050901 leukocyte tethering or rolling 2/969 33/18722 0.515241686088148 0.718807541777006 ITGB1/ROCK1 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/969 33/18722 0.515241686088148 0.718807541777006 ZNF451/MED13 2 GO:0071295 cellular response to vitamin 2/969 33/18722 0.515241686088148 0.718807541777006 ATP2B1/TRIM24 2 GO:0099174 regulation of presynapse organization 2/969 33/18722 0.515241686088148 0.718807541777006 APP/EIF4G1 2 GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 2/969 33/18722 0.515241686088148 0.718807541777006 KANK1/TACSTD2 2 GO:1901380 negative regulation of potassium ion transmembrane transport 2/969 33/18722 0.515241686088148 0.718807541777006 CAV1/ANK3 2 GO:1902692 regulation of neuroblast proliferation 2/969 33/18722 0.515241686088148 0.718807541777006 GLI3/NF1 2 GO:1903146 regulation of autophagy of mitochondrion 2/969 33/18722 0.515241686088148 0.718807541777006 VPS13C/VDAC1 2 GO:1903715 regulation of aerobic respiration 2/969 33/18722 0.515241686088148 0.718807541777006 RHOA/DNAJC15 2 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 2/969 33/18722 0.515241686088148 0.718807541777006 NR2F2/LATS2 2 GO:1905606 regulation of presynapse assembly 2/969 33/18722 0.515241686088148 0.718807541777006 APP/EIF4G1 2 GO:0035567 non-canonical Wnt signaling pathway 4/969 72/18722 0.515658975198068 0.719197706000829 ZNRF3/RNF213/RHOA/CDC42 4 GO:0071867 response to monoamine 6/969 111/18722 0.516213559912964 0.719587106989903 APP/ATP2B4/PDE4B/SLC9A1/ID1/CAV2 6 GO:0071869 response to catecholamine 6/969 111/18722 0.516213559912964 0.719587106989903 APP/ATP2B4/PDE4B/SLC9A1/ID1/CAV2 6 GO:0001959 regulation of cytokine-mediated signaling pathway 8/969 150/18722 0.516916784944961 0.720375231499298 CAV1/GSTP1/TRIM44/HSPA1A/ADAR/HSPA1B/CD24/CASP4 8 GO:1904950 negative regulation of establishment of protein localization 7/969 131/18722 0.52063908927797 0.72134697201755 LMAN1/ANXA1/FRMD4A/FERMT1/TXN/REST/GOPC 7 GO:0034502 protein localization to chromosome 5/969 92/18722 0.520783565111807 0.72134697201755 ATRX/NIPBL/SETD2/CDK1/CCT8 5 GO:0022412 cellular process involved in reproduction in multicellular organism 20/969 384/18722 0.521454256724993 0.72134697201755 RPS6/DYNLL1/ITGB1/LGR5/EIF2S2/JAM3/AFF4/SMARCA2/DIAPH2/SPESP1/CELF1/SMAD5/DNMT3A/ZFX/YTHDC1/QKI/TMF1/CDYL/CCNB1/AURKA 20 GO:0033059 cellular pigmentation 3/969 53/18722 0.521912991518732 0.72134697201755 CD63/RAB11A/RAB17 3 GO:0046390 ribose phosphate biosynthetic process 10/969 190/18722 0.524465522917793 0.72134697201755 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/PYGL/STOML2/IMPDH2/AK2 10 GO:0001711 endodermal cell fate commitment 1/969 14/18722 0.524929685147865 0.72134697201755 RTF1 1 GO:0002829 negative regulation of type 2 immune response 1/969 14/18722 0.524929685147865 0.72134697201755 ANXA1 1 GO:0003188 heart valve formation 1/969 14/18722 0.524929685147865 0.72134697201755 GJA5 1 GO:0003214 cardiac left ventricle morphogenesis 1/969 14/18722 0.524929685147865 0.72134697201755 RBPJ 1 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/969 14/18722 0.524929685147865 0.72134697201755 EZR 1 GO:0006465 signal peptide processing 1/969 14/18722 0.524929685147865 0.72134697201755 SPPL3 1 GO:0006521 regulation of cellular amino acid metabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 ATP2B4 1 GO:0006596 polyamine biosynthetic process 1/969 14/18722 0.524929685147865 0.72134697201755 OAZ1 1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 1/969 14/18722 0.524929685147865 0.72134697201755 PRLR 1 GO:0009071 serine family amino acid catabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 GLDC 1 GO:0009214 cyclic nucleotide catabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 PDE4B 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/969 14/18722 0.524929685147865 0.72134697201755 MYLIP 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/969 14/18722 0.524929685147865 0.72134697201755 DAG1 1 GO:0018158 protein oxidation 1/969 14/18722 0.524929685147865 0.72134697201755 GPX1 1 GO:0030049 muscle filament sliding 1/969 14/18722 0.524929685147865 0.72134697201755 MYL6 1 GO:0030213 hyaluronan biosynthetic process 1/969 14/18722 0.524929685147865 0.72134697201755 CLTC 1 GO:0031115 negative regulation of microtubule polymerization 1/969 14/18722 0.524929685147865 0.72134697201755 STMN1 1 GO:0032688 negative regulation of interferon-beta production 1/969 14/18722 0.524929685147865 0.72134697201755 YY1 1 GO:0033169 histone H3-K9 demethylation 1/969 14/18722 0.524929685147865 0.72134697201755 JMJD1C 1 GO:0034616 response to laminar fluid shear stress 1/969 14/18722 0.524929685147865 0.72134697201755 ABCA1 1 GO:0035641 locomotory exploration behavior 1/969 14/18722 0.524929685147865 0.72134697201755 DPP4 1 GO:0036295 cellular response to increased oxygen levels 1/969 14/18722 0.524929685147865 0.72134697201755 CAV1 1 GO:0045472 response to ether 1/969 14/18722 0.524929685147865 0.72134697201755 LARP1 1 GO:0045820 negative regulation of glycolytic process 1/969 14/18722 0.524929685147865 0.72134697201755 NCOR1 1 GO:0045837 negative regulation of membrane potential 1/969 14/18722 0.524929685147865 0.72134697201755 PMAIP1 1 GO:0045989 positive regulation of striated muscle contraction 1/969 14/18722 0.524929685147865 0.72134697201755 GSTO1 1 GO:0046479 glycosphingolipid catabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 HEXA 1 GO:0046655 folic acid metabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 SLC19A1 1 GO:0047484 regulation of response to osmotic stress 1/969 14/18722 0.524929685147865 0.72134697201755 EFHD1 1 GO:0048148 behavioral response to cocaine 1/969 14/18722 0.524929685147865 0.72134697201755 HOMER1 1 GO:0048368 lateral mesoderm development 1/969 14/18722 0.524929685147865 0.72134697201755 CITED2 1 GO:0051589 negative regulation of neurotransmitter transport 1/969 14/18722 0.524929685147865 0.72134697201755 PPP1R9A 1 GO:0051764 actin crosslink formation 1/969 14/18722 0.524929685147865 0.72134697201755 EPS8 1 GO:0060088 auditory receptor cell stereocilium organization 1/969 14/18722 0.524929685147865 0.72134697201755 TRIOBP 1 GO:0061043 regulation of vascular wound healing 1/969 14/18722 0.524929685147865 0.72134697201755 XBP1 1 GO:0071285 cellular response to lithium ion 1/969 14/18722 0.524929685147865 0.72134697201755 CDH1 1 GO:0072350 tricarboxylic acid metabolic process 1/969 14/18722 0.524929685147865 0.72134697201755 IDH1 1 GO:0072498 embryonic skeletal joint development 1/969 14/18722 0.524929685147865 0.72134697201755 BMP7 1 GO:0090239 regulation of histone H4 acetylation 1/969 14/18722 0.524929685147865 0.72134697201755 IWS1 1 GO:0090281 negative regulation of calcium ion import 1/969 14/18722 0.524929685147865 0.72134697201755 VDAC1 1 GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly 1/969 14/18722 0.524929685147865 0.72134697201755 MPHOSPH8 1 GO:0090715 immunological memory formation process 1/969 14/18722 0.524929685147865 0.72134697201755 CD46 1 GO:0099638 endosome to plasma membrane protein transport 1/969 14/18722 0.524929685147865 0.72134697201755 RAB11A 1 GO:1900037 regulation of cellular response to hypoxia 1/969 14/18722 0.524929685147865 0.72134697201755 ENO1 1 GO:1904814 regulation of protein localization to chromosome, telomeric region 1/969 14/18722 0.524929685147865 0.72134697201755 CCT8 1 GO:1905208 negative regulation of cardiocyte differentiation 1/969 14/18722 0.524929685147865 0.72134697201755 EGFR 1 GO:1990173 protein localization to nucleoplasm 1/969 14/18722 0.524929685147865 0.72134697201755 CCT8 1 GO:2001256 regulation of store-operated calcium entry 1/969 14/18722 0.524929685147865 0.72134697201755 HOMER1 1 GO:0032456 endocytic recycling 4/969 73/18722 0.526617543255313 0.723095975053144 KIAA1109/RAB11A/RAB17/VPS29 4 GO:0032732 positive regulation of interleukin-1 production 4/969 73/18722 0.526617543255313 0.723095975053144 APP/HSPB1/ISL1/EGR1 4 GO:0099518 vesicle cytoskeletal trafficking 4/969 73/18722 0.526617543255313 0.723095975053144 DYNC1H1/KIF5B/CCDC186/ACTN4 4 GO:0048469 cell maturation 9/969 171/18722 0.528027963482772 0.724842168941678 APP/EPAS1/AKR1B1/B4GALT5/TFCP2L1/GATA3/HES1/CCNB1/AURKA 9 GO:0030595 leukocyte chemotaxis 12/969 230/18722 0.530802546975833 0.726603957642931 CSF3R/MIF/ANXA1/PLEC/DUSP1/PPIA/JAM3/S100A9/PDE4B/LGALS3/WNK1/DPP4 12 GO:0000038 very long-chain fatty acid metabolic process 2/969 34/18722 0.531396924246323 0.726603957642931 SLC27A2/HACD3 2 GO:0000096 sulfur amino acid metabolic process 2/969 34/18722 0.531396924246323 0.726603957642931 MTR/GCLM 2 GO:0006270 DNA replication initiation 2/969 34/18722 0.531396924246323 0.726603957642931 PURA/CCNE1 2 GO:0009649 entrainment of circadian clock 2/969 34/18722 0.531396924246323 0.726603957642931 GNAQ/NR2F6 2 GO:0016242 negative regulation of macroautophagy 2/969 34/18722 0.531396924246323 0.726603957642931 SMG1/HMOX1 2 GO:0032770 positive regulation of monooxygenase activity 2/969 34/18722 0.531396924246323 0.726603957642931 CALM1/KRAS 2 GO:0048854 brain morphogenesis 2/969 34/18722 0.531396924246323 0.726603957642931 NF1/SLC6A4 2 GO:0050931 pigment cell differentiation 2/969 34/18722 0.531396924246323 0.726603957642931 CD63/GLI3 2 GO:0051973 positive regulation of telomerase activity 2/969 34/18722 0.531396924246323 0.726603957642931 MAP3K4/PTGES3 2 GO:0070050 neuron cellular homeostasis 2/969 34/18722 0.531396924246323 0.726603957642931 ATP2B1/TAOK1 2 GO:0070232 regulation of T cell apoptotic process 2/969 34/18722 0.531396924246323 0.726603957642931 DOCK8/LGALS3 2 GO:0086019 cell-cell signaling involved in cardiac conduction 2/969 34/18722 0.531396924246323 0.726603957642931 GJA1/GJA5 2 GO:0090075 relaxation of muscle 2/969 34/18722 0.531396924246323 0.726603957642931 PDE4B/SRI 2 GO:2000780 negative regulation of double-strand break repair 2/969 34/18722 0.531396924246323 0.726603957642931 RIF1/UBR5 2 GO:0044106 cellular amine metabolic process 6/969 113/18722 0.533825798068571 0.729543310854172 OAZ1/LY6E/ATP2B4/EPAS1/AKR1B1/GATA3 6 GO:0044344 cellular response to fibroblast growth factor stimulus 6/969 113/18722 0.533825798068571 0.729543310854172 ZFP36L1/KDM5B/GPC1/SETX/GCLM/GATA3 6 GO:0007215 glutamate receptor signaling pathway 3/969 54/18722 0.53463980467399 0.72989227252515 APP/GNAQ/HOMER1 3 GO:0014888 striated muscle adaptation 3/969 54/18722 0.53463980467399 0.72989227252515 ATP2B4/CFLAR/CAMK2G 3 GO:0060350 endochondral bone morphogenesis 3/969 54/18722 0.53463980467399 0.72989227252515 TRIP11/MMP14/SERPINH1 3 GO:2000179 positive regulation of neural precursor cell proliferation 3/969 54/18722 0.53463980467399 0.72989227252515 LRP2/ADGRG1/GLI3 3 GO:0070372 regulation of ERK1 and ERK2 cascade 16/969 309/18722 0.535989602539555 0.731543918221915 EGFR/LRP1/SEMA6A/APP/MIF/FBLN1/EIF3A/DUSP6/DUSP1/DLG1/GSTP1/NRP1/GCNT2/CFLAR/EZR/TPBG 16 GO:0002437 inflammatory response to antigenic stimulus 4/969 74/18722 0.537454406342017 0.732777648719901 GPX1/MAPK14/RBPJ/GATA3 4 GO:0006635 fatty acid beta-oxidation 4/969 74/18722 0.537454406342017 0.732777648719901 CROT/SLC27A2/HADHA/ETFA 4 GO:0010822 positive regulation of mitochondrion organization 4/969 74/18722 0.537454406342017 0.732777648719901 PMAIP1/NMT1/VDAC1/AURKA 4 GO:0046323 glucose import 4/969 74/18722 0.537454406342017 0.732777648719901 SLC2A1/PIK3R1/SORBS1/MAPK14 4 GO:0006302 double-strand break repair 13/969 251/18722 0.539539459988925 0.732808733286992 FUS/PRKDC/RIF1/PARP1/NIPBL/SETD2/RAD50/UBR5/KDM2A/YY1/SETX/UVRAG/SFPQ 13 GO:0032103 positive regulation of response to external stimulus 22/969 427/18722 0.540369436250991 0.732808733286992 NEAT1/EGFR/LRP1/APP/MET/GRN/PRKDC/HSPB1/IL6ST/CTSC/PUM1/NRP1/TMSB4X/CADM1/S100A9/ANKRD17/PUM2/WNK1/EP300/NFKBIA/SFPQ/TPBG 22 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 10/969 193/18722 0.54464189191818 0.732808733286992 MIF/IQGAP1/IGF2/IL6ST/ISL1/NRP1/RICTOR/CSH1/CD24/HES1 10 GO:0008277 regulation of G protein-coupled receptor signaling pathway 7/969 134/18722 0.544869673921239 0.732808733286992 MET/ROCK1/ATP2B4/PDE4B/NMT1/DYNLT1/STMN1 7 GO:0010876 lipid localization 23/969 448/18722 0.546957394797586 0.732808733286992 LRP1/CAV1/ITGAV/CROT/SLC2A1/ANXA1/PLIN2/ANXA2/PSAP/CYP19A1/SLC27A2/KDM5B/KCNN4/SYT7/ABCA1/NRIP1/ATP10D/NFKBIA/RXRA/TMF1/OSBPL9/NPC2/STOML2 23 GO:0000768 syncytium formation by plasma membrane fusion 3/969 55/18722 0.547172215658662 0.732808733286992 MAPK14/CFLAR/MYOF 3 GO:0008333 endosome to lysosome transport 3/969 55/18722 0.547172215658662 0.732808733286992 RHOB/HOOK2/HOOK3 3 GO:0042220 response to cocaine 3/969 55/18722 0.547172215658662 0.732808733286992 HSPA5/DNMT3A/HOMER1 3 GO:0140253 cell-cell fusion 3/969 55/18722 0.547172215658662 0.732808733286992 MAPK14/CFLAR/MYOF 3 GO:1902991 regulation of amyloid precursor protein catabolic process 3/969 55/18722 0.547172215658662 0.732808733286992 ROCK1/RTN4/FLOT2 3 GO:1905517 macrophage migration 3/969 55/18722 0.547172215658662 0.732808733286992 MIF/MMP14/LGALS3 3 GO:0000460 maturation of 5.8S rRNA 2/969 35/18722 0.547180439779924 0.732808733286992 RPS21/PRKDC 2 GO:0006298 mismatch repair 2/969 35/18722 0.547180439779924 0.732808733286992 SETD2/XPC 2 GO:0006471 protein ADP-ribosylation 2/969 35/18722 0.547180439779924 0.732808733286992 PARP1/ARF4 2 GO:0010837 regulation of keratinocyte proliferation 2/969 35/18722 0.547180439779924 0.732808733286992 ZFP36L1/SRSF6 2 GO:0034331 cell junction maintenance 2/969 35/18722 0.547180439779924 0.732808733286992 DLG1/ERC1 2 GO:0042462 eye photoreceptor cell development 2/969 35/18722 0.547180439779924 0.732808733286992 TUG1/NAGLU 2 GO:0046471 phosphatidylglycerol metabolic process 2/969 35/18722 0.547180439779924 0.732808733286992 HADHA/STOML2 2 GO:0046627 negative regulation of insulin receptor signaling pathway 2/969 35/18722 0.547180439779924 0.732808733286992 KANK1/PTPRE 2 GO:0048821 erythrocyte development 2/969 35/18722 0.547180439779924 0.732808733286992 RPS6/CITED2 2 GO:0070536 protein K63-linked deubiquitination 2/969 35/18722 0.547180439779924 0.732808733286992 USP27X/USP8 2 GO:0098801 regulation of renal system process 2/969 35/18722 0.547180439779924 0.732808733286992 GJA1/GJA5 2 GO:0098810 neurotransmitter reuptake 2/969 35/18722 0.547180439779924 0.732808733286992 ITGB1/SLC6A4 2 GO:0002292 T cell differentiation involved in immune response 4/969 75/18722 0.548164681882044 0.732808733286992 CD46/ANXA1/FOXP1/GATA3 4 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 12/969 233/18722 0.549139134924091 0.732808733286992 LGR5/ADGRG1/LGR4/WASF2/AKAP13/PSAP/ADRB1/GNAQ/ATP2B4/PDE4B/ABCA1/GNA12 12 GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/969 15/18722 0.549536438146139 0.732808733286992 RPS21 1 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/969 15/18722 0.549536438146139 0.732808733286992 RPS21 1 GO:0002679 respiratory burst involved in defense response 1/969 15/18722 0.549536438146139 0.732808733286992 GRN 1 GO:0006089 lactate metabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 LDHA 1 GO:0006878 cellular copper ion homeostasis 1/969 15/18722 0.549536438146139 0.732808733286992 APP 1 GO:0007000 nucleolus organization 1/969 15/18722 0.549536438146139 0.732808733286992 BAZ2A 1 GO:0007216 G protein-coupled glutamate receptor signaling pathway 1/969 15/18722 0.549536438146139 0.732808733286992 HOMER1 1 GO:0010763 positive regulation of fibroblast migration 1/969 15/18722 0.549536438146139 0.732808733286992 ITGB1 1 GO:0010820 positive regulation of T cell chemotaxis 1/969 15/18722 0.549536438146139 0.732808733286992 WNK1 1 GO:0010889 regulation of sequestering of triglyceride 1/969 15/18722 0.549536438146139 0.732808733286992 PLIN2 1 GO:0014733 regulation of skeletal muscle adaptation 1/969 15/18722 0.549536438146139 0.732808733286992 CAMK2G 1 GO:0015697 quaternary ammonium group transport 1/969 15/18722 0.549536438146139 0.732808733286992 SLC38A2 1 GO:0018146 keratan sulfate biosynthetic process 1/969 15/18722 0.549536438146139 0.732808733286992 B3GNT2 1 GO:0018216 peptidyl-arginine methylation 1/969 15/18722 0.549536438146139 0.732808733286992 PRMT1 1 GO:0018410 C-terminal protein amino acid modification 1/969 15/18722 0.549536438146139 0.732808733286992 LCMT1 1 GO:0019511 peptidyl-proline hydroxylation 1/969 15/18722 0.549536438146139 0.732808733286992 P4HB 1 GO:0023035 CD40 signaling pathway 1/969 15/18722 0.549536438146139 0.732808733286992 ITGB1 1 GO:0031269 pseudopodium assembly 1/969 15/18722 0.549536438146139 0.732808733286992 CDC42 1 GO:0032486 Rap protein signal transduction 1/969 15/18722 0.549536438146139 0.732808733286992 TIMP2 1 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1/969 15/18722 0.549536438146139 0.732808733286992 ISL1 1 GO:0033275 actin-myosin filament sliding 1/969 15/18722 0.549536438146139 0.732808733286992 MYL6 1 GO:0034380 high-density lipoprotein particle assembly 1/969 15/18722 0.549536438146139 0.732808733286992 ABCA1 1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 1/969 15/18722 0.549536438146139 0.732808733286992 CITED2 1 GO:0035627 ceramide transport 1/969 15/18722 0.549536438146139 0.732808733286992 PSAP 1 GO:0036124 histone H3-K9 trimethylation 1/969 15/18722 0.549536438146139 0.732808733286992 ATRX 1 GO:0036376 sodium ion export across plasma membrane 1/969 15/18722 0.549536438146139 0.732808733286992 SLC9A1 1 GO:0042159 lipoprotein catabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 CTSD 1 GO:0042754 negative regulation of circadian rhythm 1/969 15/18722 0.549536438146139 0.732808733286992 SFPQ 1 GO:0042976 activation of Janus kinase activity 1/969 15/18722 0.549536438146139 0.732808733286992 PRLR 1 GO:0043508 negative regulation of JUN kinase activity 1/969 15/18722 0.549536438146139 0.732808733286992 GSTP1 1 GO:0043584 nose development 1/969 15/18722 0.549536438146139 0.732808733286992 GLI3 1 GO:0043981 histone H4-K5 acetylation 1/969 15/18722 0.549536438146139 0.732808733286992 PHF20 1 GO:0043982 histone H4-K8 acetylation 1/969 15/18722 0.549536438146139 0.732808733286992 PHF20 1 GO:0044793 negative regulation by host of viral process 1/969 15/18722 0.549536438146139 0.732808733286992 EIF2AK4 1 GO:0045346 regulation of MHC class II biosynthetic process 1/969 15/18722 0.549536438146139 0.732808733286992 XBP1 1 GO:0045842 positive regulation of mitotic metaphase/anaphase transition 1/969 15/18722 0.549536438146139 0.732808733286992 ANAPC11 1 GO:0046459 short-chain fatty acid metabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 ACSS1 1 GO:0046500 S-adenosylmethionine metabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 AHCYL1 1 GO:0048308 organelle inheritance 1/969 15/18722 0.549536438146139 0.732808733286992 CDK1 1 GO:0048313 Golgi inheritance 1/969 15/18722 0.549536438146139 0.732808733286992 CDK1 1 GO:0051290 protein heterotetramerization 1/969 15/18722 0.549536438146139 0.732808733286992 KRT10 1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 1/969 15/18722 0.549536438146139 0.732808733286992 HNRNPU 1 GO:0051791 medium-chain fatty acid metabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 CROT 1 GO:0051938 L-glutamate import 1/969 15/18722 0.549536438146139 0.732808733286992 ITGB1 1 GO:0055091 phospholipid homeostasis 1/969 15/18722 0.549536438146139 0.732808733286992 ABCA1 1 GO:0060049 regulation of protein glycosylation 1/969 15/18722 0.549536438146139 0.732808733286992 ARFGEF1 1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 1/969 15/18722 0.549536438146139 0.732808733286992 PGAP1 1 GO:0070071 proton-transporting two-sector ATPase complex assembly 1/969 15/18722 0.549536438146139 0.732808733286992 TM9SF4 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/969 15/18722 0.549536438146139 0.732808733286992 TM9SF4 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/969 15/18722 0.549536438146139 0.732808733286992 ATP2B4 1 GO:0072075 metanephric mesenchyme development 1/969 15/18722 0.549536438146139 0.732808733286992 BMP7 1 GO:0098712 L-glutamate import across plasma membrane 1/969 15/18722 0.549536438146139 0.732808733286992 ITGB1 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/969 15/18722 0.549536438146139 0.732808733286992 ATP2B4 1 GO:0150011 regulation of neuron projection arborization 1/969 15/18722 0.549536438146139 0.732808733286992 MACF1 1 GO:1901741 positive regulation of myoblast fusion 1/969 15/18722 0.549536438146139 0.732808733286992 MAPK14 1 GO:1901970 positive regulation of mitotic sister chromatid separation 1/969 15/18722 0.549536438146139 0.732808733286992 ANAPC11 1 GO:1903727 positive regulation of phospholipid metabolic process 1/969 15/18722 0.549536438146139 0.732808733286992 STOML2 1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 1/969 15/18722 0.549536438146139 0.732808733286992 NCOR1 1 GO:1990822 basic amino acid transmembrane transport 1/969 15/18722 0.549536438146139 0.732808733286992 SLC7A6 1 GO:2000402 negative regulation of lymphocyte migration 1/969 15/18722 0.549536438146139 0.732808733286992 MIA3 1 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 1/969 15/18722 0.549536438146139 0.732808733286992 ANXA1 1 GO:0006631 fatty acid metabolic process 20/969 390/18722 0.549991240022762 0.733228117438508 CAV1/CYP2J2/MIF/CROT/ANXA1/ACSS1/GPX4/GSTP1/GPX1/PTGES3/SLC27A2/NCOR1/HACD3/AKR1B1/MAPK14/XBP1/QKI/HADHA/ETFA/HPGD 20 GO:0042157 lipoprotein metabolic process 7/969 135/18722 0.552832631948432 0.736828190401047 LRP1/ITGAV/PGAP1/ABCA1/CTSD/NMT1/RAB3GAP2 7 GO:0046942 carboxylic acid transport 14/969 273/18722 0.553256918446361 0.737047797790236 LRP2/SLC26A2/ITGB1/GJA1/ANXA1/SLC38A1/PSAP/SLC38A2/SLC16A12/SLC1A5/SLC7A6/SLC3A2/SLC19A1/SLC13A3 14 GO:0072330 monocarboxylic acid biosynthetic process 11/969 214/18722 0.553279470097799 0.737047797790236 MIF/ANXA1/ACSS1/GPX4/GSTP1/PTGES3/SLC27A2/HACD3/XBP1/QKI/OSBPL9 11 GO:0014823 response to activity 4/969 76/18722 0.558743857492217 0.743445383706602 PRKDC/COL4A2/GCLM/CDK1 4 GO:0032543 mitochondrial translation 4/969 76/18722 0.558743857492217 0.743445383706602 IARS2/MRPS6/MRPL51/MRPS15 4 GO:2000379 positive regulation of reactive oxygen species metabolic process 4/969 76/18722 0.558743857492217 0.743445383706602 EGFR/GSTP1/SLC5A3/MAPK14 4 GO:0006687 glycosphingolipid metabolic process 3/969 56/18722 0.559504533891708 0.743445383706602 ITGB8/B4GALT5/HEXA 3 GO:0010518 positive regulation of phospholipase activity 3/969 56/18722 0.559504533891708 0.743445383706602 EGFR/GNAQ/ARF4 3 GO:0010658 striated muscle cell apoptotic process 3/969 56/18722 0.559504533891708 0.743445383706602 PPP1R10/BMP7/CFLAR 3 GO:0030166 proteoglycan biosynthetic process 3/969 56/18722 0.559504533891708 0.743445383706602 EXTL2/CHPF/TCF7L2 3 GO:0046456 icosanoid biosynthetic process 3/969 56/18722 0.559504533891708 0.743445383706602 MIF/ANXA1/PTGES3 3 GO:0070534 protein K63-linked ubiquitination 3/969 56/18722 0.559504533891708 0.743445383706602 HECTD1/UBR5/TRIM56 3 GO:0090175 regulation of establishment of planar polarity 3/969 56/18722 0.559504533891708 0.743445383706602 ZNRF3/RHOA/CDC42 3 GO:0043200 response to amino acid 6/969 116/18722 0.559720605537546 0.743543437859485 GSTP1/UFL1/RHOA/DNMT3A/XBP1/GCLM 6 GO:0046631 alpha-beta T cell activation 8/969 156/18722 0.561907367835543 0.745456835654859 RPL22/ANXA1/CTSL/GLI3/RHOA/FOXP1/GATA3/STOML2 8 GO:0002691 regulation of cellular extravasation 2/969 36/18722 0.562587401420353 0.745456835654859 JAM3/CD99 2 GO:0006699 bile acid biosynthetic process 2/969 36/18722 0.562587401420353 0.745456835654859 SLC27A2/OSBPL9 2 GO:0010762 regulation of fibroblast migration 2/969 36/18722 0.562587401420353 0.745456835654859 ITGB1/GNA12 2 GO:0036314 response to sterol 2/969 36/18722 0.562587401420353 0.745456835654859 DAG1/ABCA1 2 GO:0042092 type 2 immune response 2/969 36/18722 0.562587401420353 0.745456835654859 ANXA1/GATA3 2 GO:0042119 neutrophil activation 2/969 36/18722 0.562587401420353 0.745456835654859 GRN/ANXA3 2 GO:0051354 negative regulation of oxidoreductase activity 2/969 36/18722 0.562587401420353 0.745456835654859 CAV1/ATP2B4 2 GO:0070873 regulation of glycogen metabolic process 2/969 36/18722 0.562587401420353 0.745456835654859 IGF2/SORBS1 2 GO:0090313 regulation of protein targeting to membrane 2/969 36/18722 0.562587401420353 0.745456835654859 TCAF1/ANK3 2 GO:0022408 negative regulation of cell-cell adhesion 10/969 196/18722 0.564494809830908 0.747794645418588 CDH1/DLG5/ANXA1/DLG1/MIA3/GLI3/JAG1/LGALS3/PAWR/WNK1 10 GO:0140056 organelle localization by membrane tethering 4/969 77/18722 0.569187781490183 0.748080492522008 CALM1/AHCYL1/CAV2/VAMP3 4 GO:0006333 chromatin assembly or disassembly 9/969 177/18722 0.570071741014609 0.748080492522008 ATRX/NPM1/BAZ1B/BRD2/HP1BP3/ARID1A/RSF1/HMGA1/BAZ2A 9 GO:0006949 syncytium formation 3/969 57/18722 0.571631746602276 0.748080492522008 MAPK14/CFLAR/MYOF 3 GO:0010257 NADH dehydrogenase complex assembly 3/969 57/18722 0.571631746602276 0.748080492522008 NDUFA11/NDUFA13/NDUFA6 3 GO:0032981 mitochondrial respiratory chain complex I assembly 3/969 57/18722 0.571631746602276 0.748080492522008 NDUFA11/NDUFA13/NDUFA6 3 GO:0018108 peptidyl-tyrosine phosphorylation 19/969 375/18722 0.571934098302392 0.748080492522008 EGFR/CAV1/APP/MIF/MET/IQGAP1/IGF2/EPHB4/IL6ST/ISL1/NRP1/IGF1R/BAZ1B/PRLR/EFEMP1/RICTOR/CSH1/CD24/HES1 19 GO:0001574 ganglioside biosynthetic process 1/969 16/18722 0.572869906443375 0.748080492522008 B4GALT5 1 GO:0001845 phagolysosome assembly 1/969 16/18722 0.572869906443375 0.748080492522008 SYT7 1 GO:0002093 auditory receptor cell morphogenesis 1/969 16/18722 0.572869906443375 0.748080492522008 TRIOBP 1 GO:0002566 somatic diversification of immune receptors via somatic mutation 1/969 16/18722 0.572869906443375 0.748080492522008 ADAR 1 GO:0002713 negative regulation of B cell mediated immunity 1/969 16/18722 0.572869906443375 0.748080492522008 CD46 1 GO:0002830 positive regulation of type 2 immune response 1/969 16/18722 0.572869906443375 0.748080492522008 GATA3 1 GO:0002890 negative regulation of immunoglobulin mediated immune response 1/969 16/18722 0.572869906443375 0.748080492522008 CD46 1 GO:0002921 negative regulation of humoral immune response 1/969 16/18722 0.572869906443375 0.748080492522008 CD46 1 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 1/969 16/18722 0.572869906443375 0.748080492522008 RBPJ 1 GO:0006004 fucose metabolic process 1/969 16/18722 0.572869906443375 0.748080492522008 FUT8 1 GO:0006544 glycine metabolic process 1/969 16/18722 0.572869906443375 0.748080492522008 GLDC 1 GO:0006555 methionine metabolic process 1/969 16/18722 0.572869906443375 0.748080492522008 MTR 1 GO:0006750 glutathione biosynthetic process 1/969 16/18722 0.572869906443375 0.748080492522008 GCLM 1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1/969 16/18722 0.572869906443375 0.748080492522008 RPL26 1 GO:0007635 chemosensory behavior 1/969 16/18722 0.572869906443375 0.748080492522008 TPBG 1 GO:0010819 regulation of T cell chemotaxis 1/969 16/18722 0.572869906443375 0.748080492522008 WNK1 1 GO:0016584 nucleosome positioning 1/969 16/18722 0.572869906443375 0.748080492522008 RSF1 1 GO:0019377 glycolipid catabolic process 1/969 16/18722 0.572869906443375 0.748080492522008 HEXA 1 GO:0030575 nuclear body organization 1/969 16/18722 0.572869906443375 0.748080492522008 SF1 1 GO:0035067 negative regulation of histone acetylation 1/969 16/18722 0.572869906443375 0.748080492522008 ZNF451 1 GO:0035970 peptidyl-threonine dephosphorylation 1/969 16/18722 0.572869906443375 0.748080492522008 DUSP1 1 GO:0042407 cristae formation 1/969 16/18722 0.572869906443375 0.748080492522008 AFG3L2 1 GO:0044804 autophagy of nucleus 1/969 16/18722 0.572869906443375 0.748080492522008 RB1CC1 1 GO:0044849 estrous cycle 1/969 16/18722 0.572869906443375 0.748080492522008 EGR1 1 GO:0045342 MHC class II biosynthetic process 1/969 16/18722 0.572869906443375 0.748080492522008 XBP1 1 GO:0045721 negative regulation of gluconeogenesis 1/969 16/18722 0.572869906443375 0.748080492522008 EP300 1 GO:0045722 positive regulation of gluconeogenesis 1/969 16/18722 0.572869906443375 0.748080492522008 DDB1 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/969 16/18722 0.572869906443375 0.748080492522008 MPHOSPH8 1 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 1/969 16/18722 0.572869906443375 0.748080492522008 NR2F6 1 GO:0055089 fatty acid homeostasis 1/969 16/18722 0.572869906443375 0.748080492522008 XBP1 1 GO:0060004 reflex 1/969 16/18722 0.572869906443375 0.748080492522008 AFG3L2 1 GO:0060572 morphogenesis of an epithelial bud 1/969 16/18722 0.572869906443375 0.748080492522008 BMP7 1 GO:0061684 chaperone-mediated autophagy 1/969 16/18722 0.572869906443375 0.748080492522008 EEF1A1 1 GO:0070200 establishment of protein localization to telomere 1/969 16/18722 0.572869906443375 0.748080492522008 CCT8 1 GO:0070242 thymocyte apoptotic process 1/969 16/18722 0.572869906443375 0.748080492522008 GLI3 1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 1/969 16/18722 0.572869906443375 0.748080492522008 TPRKB 1 GO:0071361 cellular response to ethanol 1/969 16/18722 0.572869906443375 0.748080492522008 DNMT3A 1 GO:0080009 mRNA methylation 1/969 16/18722 0.572869906443375 0.748080492522008 ZC3H13 1 GO:0090520 sphingolipid mediated signaling pathway 1/969 16/18722 0.572869906443375 0.748080492522008 EZR 1 GO:0097202 activation of cysteine-type endopeptidase activity 1/969 16/18722 0.572869906443375 0.748080492522008 ASPH 1 GO:0099116 tRNA 5'-end processing 1/969 16/18722 0.572869906443375 0.748080492522008 SSB 1 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 1/969 16/18722 0.572869906443375 0.748080492522008 ATP2B1 1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1/969 16/18722 0.572869906443375 0.748080492522008 SEMA6A 1 GO:1901201 regulation of extracellular matrix assembly 1/969 16/18722 0.572869906443375 0.748080492522008 DAG1 1 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/969 16/18722 0.572869906443375 0.748080492522008 ANAPC11 1 GO:1902931 negative regulation of alcohol biosynthetic process 1/969 16/18722 0.572869906443375 0.748080492522008 REST 1 GO:1904862 inhibitory synapse assembly 1/969 16/18722 0.572869906443375 0.748080492522008 PLXNB1 1 GO:1905906 regulation of amyloid fibril formation 1/969 16/18722 0.572869906443375 0.748080492522008 APP 1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1/969 16/18722 0.572869906443375 0.748080492522008 ZNRF3 1 GO:2000765 regulation of cytoplasmic translation 1/969 16/18722 0.572869906443375 0.748080492522008 PKM 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/969 16/18722 0.572869906443375 0.748080492522008 CD63 1 GO:0000724 double-strand break repair via homologous recombination 7/969 138/18722 0.576347048819535 0.751085650606374 FUS/RIF1/PARP1/NIPBL/SETD2/YY1/SFPQ 7 GO:0009308 amine metabolic process 6/969 118/18722 0.576601571236685 0.751085650606374 OAZ1/LY6E/ATP2B4/EPAS1/AKR1B1/GATA3 6 GO:0071346 cellular response to interferon-gamma 6/969 118/18722 0.576601571236685 0.751085650606374 GAPDH/RPL13A/ACTG1/KIF5B/CDC42/VAMP3 6 GO:0048015 phosphatidylinositol-mediated signaling 9/969 178/18722 0.576922385275118 0.751085650606374 EGFR/ZFP36L1/IGF1R/NF1/EXOC1/PIK3R1/PLXNB1/GATA3/EZR 9 GO:0048167 regulation of synaptic plasticity 10/969 198/18722 0.577530914464506 0.751085650606374 APP/PPP1R9A/ERC1/SYT7/RAB11A/EIF2AK4/MME/VAMP2/KRAS/CDC20 10 GO:0000154 rRNA modification 2/969 37/18722 0.577614471830658 0.751085650606374 NHP2/NOP10 2 GO:0030513 positive regulation of BMP signaling pathway 2/969 37/18722 0.577614471830658 0.751085650606374 RBPJ/HES1 2 GO:0031646 positive regulation of nervous system process 2/969 37/18722 0.577614471830658 0.751085650606374 DAG1/DICER1 2 GO:0033363 secretory granule organization 2/969 37/18722 0.577614471830658 0.751085650606374 ABCA1/TMF1 2 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 2/969 37/18722 0.577614471830658 0.751085650606374 GPC1/GATA3 2 GO:0042178 xenobiotic catabolic process 2/969 37/18722 0.577614471830658 0.751085650606374 CYP2J2/GSTO1 2 GO:0042401 cellular biogenic amine biosynthetic process 2/969 37/18722 0.577614471830658 0.751085650606374 OAZ1/GATA3 2 GO:0043029 T cell homeostasis 2/969 37/18722 0.577614471830658 0.751085650606374 RPS6/PMAIP1 2 GO:0043687 post-translational protein modification 2/969 37/18722 0.577614471830658 0.751085650606374 LCMT1/UCHL3 2 GO:0050775 positive regulation of dendrite morphogenesis 2/969 37/18722 0.577614471830658 0.751085650606374 CUX1/OBSL1 2 GO:0071985 multivesicular body sorting pathway 2/969 37/18722 0.577614471830658 0.751085650606374 EXPH5/UVRAG 2 GO:1900077 negative regulation of cellular response to insulin stimulus 2/969 37/18722 0.577614471830658 0.751085650606374 KANK1/PTPRE 2 GO:0051259 protein complex oligomerization 12/969 238/18722 0.579104236647991 0.752778673775622 ALDOA/FUS/MIF/RNF213/SLC9A1/SLC1A5/YME1L1/HGSNAT/HOMER1/STOML2/PRMT1/KRT10 12 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 4/969 78/18722 0.579492653004081 0.752778673775622 PMAIP1/S100A9/CFLAR/PDCD6 4 GO:0035050 embryonic heart tube development 4/969 78/18722 0.579492653004081 0.752778673775622 TBX3/AHI1/CITED2/HES1 4 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 4/969 78/18722 0.579492653004081 0.752778673775622 ANXA1/NRP1/RHOA/HMOX1 4 GO:0002763 positive regulation of myeloid leukocyte differentiation 3/969 58/18722 0.583549486321797 0.757107650327138 JUN/FOS/ZFP36L1 3 GO:0009161 ribonucleoside monophosphate metabolic process 3/969 58/18722 0.583549486321797 0.757107650327138 DLG1/IMPDH2/AK2 3 GO:0032481 positive regulation of type I interferon production 3/969 58/18722 0.583549486321797 0.757107650327138 GAPDH/SETD2/TRIM56 3 GO:0034340 response to type I interferon 3/969 58/18722 0.583549486321797 0.757107650327138 SETD2/TRIM56/ADAR 3 GO:0097035 regulation of membrane lipid distribution 3/969 58/18722 0.583549486321797 0.757107650327138 KCNN4/ABCA1/ATP10D 3 GO:0006323 DNA packaging 10/969 199/18722 0.583985136617655 0.757484816074426 ATRX/NPM1/BRD2/HP1BP3/RSF1/BAZ2A/BANF1/CDK1/NUSAP1/CCNB1 10 GO:0071805 potassium ion transmembrane transport 11/969 219/18722 0.584425438049556 0.757867826115876 AKAP9/CAV1/ITGB1/CD63/ANK3/DLG1/KCNN4/SLC9A1/WNK1/VAMP2/YWHAE 11 GO:0030282 bone mineralization 6/969 119/18722 0.584919703938226 0.758320608479576 FBN2/ATP2B1/LGR4/TFAP2A/LTBP3/BMP7 6 GO:0021510 spinal cord development 5/969 99/18722 0.586603519732095 0.759938025314806 LMO4/SOX4/ISL1/GLI3/NF1 5 GO:0060291 long-term synaptic potentiation 5/969 99/18722 0.586603519732095 0.759938025314806 APP/PPP1R9A/EIF2AK4/MME/VAMP2 5 GO:0060996 dendritic spine development 5/969 99/18722 0.586603519732095 0.759938025314806 CFL1/DLG5/PPP1R9A/CDC42/ARF4 5 GO:0007204 positive regulation of cytosolic calcium ion concentration 16/969 319/18722 0.588069383255706 0.760586160775055 LRP1/CAV1/ITGAV/GSTO1/GJA1/DIAPH1/ATP2B4/MCOLN3/TRPV6/DMD/CALM1/DDIT3/SPPL3/CD24/CALM2/SRI 16 GO:0001895 retina homeostasis 4/969 79/18722 0.589655011748663 0.760586160775055 ACTG1/SLC2A1/PRDX1/HSPB1 4 GO:0006029 proteoglycan metabolic process 4/969 79/18722 0.589655011748663 0.760586160775055 EXTL2/CHPF/TCF7L2/GPC1 4 GO:1901184 regulation of ERBB signaling pathway 4/969 79/18722 0.589655011748663 0.760586160775055 EGFR/PTPN12/RBPJ/RTN4 4 GO:0015698 inorganic anion transport 9/969 180/18722 0.590475362276789 0.760586160775055 SLC26A2/CLIC3/GABRE/CLDN4/SLC13A4/CLIC1/PCYOX1/VDAC1/VDAC2 9 GO:0000725 recombinational repair 7/969 140/18722 0.591690161922923 0.760586160775055 FUS/RIF1/PARP1/NIPBL/SETD2/YY1/SFPQ 7 GO:0006882 cellular zinc ion homeostasis 2/969 38/18722 0.592259666194232 0.760586160775055 SLC39A10/S100A9 2 GO:0009309 amine biosynthetic process 2/969 38/18722 0.592259666194232 0.760586160775055 OAZ1/GATA3 2 GO:0030279 negative regulation of ossification 2/969 38/18722 0.592259666194232 0.760586160775055 LTBP3/RBPJ 2 GO:0048246 macrophage chemotaxis 2/969 38/18722 0.592259666194232 0.760586160775055 MIF/LGALS3 2 GO:1901186 positive regulation of ERBB signaling pathway 2/969 38/18722 0.592259666194232 0.760586160775055 RBPJ/RTN4 2 GO:1903725 regulation of phospholipid metabolic process 2/969 38/18722 0.592259666194232 0.760586160775055 IDH1/STOML2 2 GO:0000097 sulfur amino acid biosynthetic process 1/969 17/18722 0.594995912038177 0.760586160775055 MTR 1 GO:0001675 acrosome assembly 1/969 17/18722 0.594995912038177 0.760586160775055 TMF1 1 GO:0006577 amino-acid betaine metabolic process 1/969 17/18722 0.594995912038177 0.760586160775055 CROT 1 GO:0006901 vesicle coating 1/969 17/18722 0.594995912038177 0.760586160775055 PDCD6 1 GO:0007076 mitotic chromosome condensation 1/969 17/18722 0.594995912038177 0.760586160775055 NUSAP1 1 GO:0007096 regulation of exit from mitosis 1/969 17/18722 0.594995912038177 0.760586160775055 UBE2C 1 GO:0007351 tripartite regional subdivision 1/969 17/18722 0.594995912038177 0.760586160775055 TBX3 1 GO:0008334 histone mRNA metabolic process 1/969 17/18722 0.594995912038177 0.760586160775055 SSB 1 GO:0008340 determination of adult lifespan 1/969 17/18722 0.594995912038177 0.760586160775055 TFCP2L1 1 GO:0008595 anterior/posterior axis specification, embryo 1/969 17/18722 0.594995912038177 0.760586160775055 TBX3 1 GO:0010470 regulation of gastrulation 1/969 17/18722 0.594995912038177 0.760586160775055 DAG1 1 GO:0010612 regulation of cardiac muscle adaptation 1/969 17/18722 0.594995912038177 0.760586160775055 ATP2B4 1 GO:0020027 hemoglobin metabolic process 1/969 17/18722 0.594995912038177 0.760586160775055 PRMT1 1 GO:0021513 spinal cord dorsal/ventral patterning 1/969 17/18722 0.594995912038177 0.760586160775055 GLI3 1 GO:0030322 stabilization of membrane potential 1/969 17/18722 0.594995912038177 0.760586160775055 KCNN4 1 GO:0031573 mitotic intra-S DNA damage checkpoint signaling 1/969 17/18722 0.594995912038177 0.760586160775055 XPC 1 GO:0032604 granulocyte macrophage colony-stimulating factor production 1/969 17/18722 0.594995912038177 0.760586160775055 ISL1 1 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 1/969 17/18722 0.594995912038177 0.760586160775055 ISL1 1 GO:0036065 fucosylation 1/969 17/18722 0.594995912038177 0.760586160775055 FUT8 1 GO:0038065 collagen-activated signaling pathway 1/969 17/18722 0.594995912038177 0.760586160775055 COL4A2 1 GO:0042448 progesterone metabolic process 1/969 17/18722 0.594995912038177 0.760586160775055 EGR1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 1/969 17/18722 0.594995912038177 0.760586160775055 CAV1 1 GO:0042753 positive regulation of circadian rhythm 1/969 17/18722 0.594995912038177 0.760586160775055 THRAP3 1 GO:0042772 DNA damage response, signal transduction resulting in transcription 1/969 17/18722 0.594995912038177 0.760586160775055 RPL26 1 GO:0043968 histone H2A acetylation 1/969 17/18722 0.594995912038177 0.760586160775055 MORF4L2 1 GO:0045591 positive regulation of regulatory T cell differentiation 1/969 17/18722 0.594995912038177 0.760586160775055 CD46 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/969 17/18722 0.594995912038177 0.760586160775055 SYT7 1 GO:0051580 regulation of neurotransmitter uptake 1/969 17/18722 0.594995912038177 0.760586160775055 ITGB1 1 GO:0051797 regulation of hair follicle development 1/969 17/18722 0.594995912038177 0.760586160775055 FERMT1 1 GO:0055003 cardiac myofibril assembly 1/969 17/18722 0.594995912038177 0.760586160775055 OBSL1 1 GO:0055119 relaxation of cardiac muscle 1/969 17/18722 0.594995912038177 0.760586160775055 PDE4B 1 GO:0060263 regulation of respiratory burst 1/969 17/18722 0.594995912038177 0.760586160775055 GRN 1 GO:0060644 mammary gland epithelial cell differentiation 1/969 17/18722 0.594995912038177 0.760586160775055 LBH 1 GO:0061158 3'-UTR-mediated mRNA destabilization 1/969 17/18722 0.594995912038177 0.760586160775055 ZFP36L1 1 GO:0071371 cellular response to gonadotropin stimulus 1/969 17/18722 0.594995912038177 0.760586160775055 GCLM 1 GO:0090399 replicative senescence 1/969 17/18722 0.594995912038177 0.760586160775055 MME 1 GO:0090713 immunological memory process 1/969 17/18722 0.594995912038177 0.760586160775055 CD46 1 GO:1900363 regulation of mRNA polyadenylation 1/969 17/18722 0.594995912038177 0.760586160775055 YTHDC1 1 GO:1901569 fatty acid derivative catabolic process 1/969 17/18722 0.594995912038177 0.760586160775055 HPGD 1 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 1/969 17/18722 0.594995912038177 0.760586160775055 ATP2B4 1 GO:1904262 negative regulation of TORC1 signaling 1/969 17/18722 0.594995912038177 0.760586160775055 ITFG2 1 GO:1904355 positive regulation of telomere capping 1/969 17/18722 0.594995912038177 0.760586160775055 MAP3K4 1 GO:0033013 tetrapyrrole metabolic process 3/969 59/18722 0.595253998769609 0.760586160775055 MTR/NFE2L1/HMOX1 3 GO:0046324 regulation of glucose import 3/969 59/18722 0.595253998769609 0.760586160775055 PIK3R1/SORBS1/MAPK14 3 GO:0045807 positive regulation of endocytosis 5/969 100/18722 0.5955989581342 0.760840908142099 LRP1/CD63/ANXA2/AHI1/CDC42 5 GO:0032102 negative regulation of response to external stimulus 21/969 420/18722 0.59713296779479 0.762614098166074 SEMA6A/MIF/GRN/SEMA6D/GJA1/SERPINB9/ASH1L/ISL1/DUSP1/ANXA2/GSTP1/NRP1/GPX1/ADAR/CHD8/MAPK14/PCBP2/HTRA1/DPP4/GATA3/NUCB2 21 GO:0051650 establishment of vesicle localization 8/969 161/18722 0.597958329431521 0.763481609970468 DYNC1H1/TRIP11/KIF5B/RAB11A/CCDC186/ACTN4/PDCD6/RAB17 8 GO:0071229 cellular response to acid chemical 4/969 80/18722 0.599671727528149 0.765482278471448 PLEC/DNMT3A/XBP1/GCLM 4 GO:0009260 ribonucleotide biosynthetic process 9/969 182/18722 0.603821244580874 0.77040278910636 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0048017 inositol lipid-mediated signaling 9/969 182/18722 0.603821244580874 0.77040278910636 EGFR/ZFP36L1/IGF1R/NF1/EXOC1/PIK3R1/PLXNB1/GATA3/EZR 9 GO:0006576 cellular biogenic amine metabolic process 5/969 101/18722 0.604484139377285 0.771060315446836 OAZ1/LY6E/EPAS1/AKR1B1/GATA3 5 GO:0002701 negative regulation of production of molecular mediator of immune response 2/969 39/18722 0.606522221414914 0.772521037304936 PRKDC/HMOX1 2 GO:0007618 mating 2/969 39/18722 0.606522221414914 0.772521037304936 APP/SLC6A4 2 GO:0043267 negative regulation of potassium ion transport 2/969 39/18722 0.606522221414914 0.772521037304936 CAV1/ANK3 2 GO:1902742 apoptotic process involved in development 2/969 39/18722 0.606522221414914 0.772521037304936 LRP5/BMP7 2 GO:0009620 response to fungus 3/969 60/18722 0.606742111237703 0.772521037304936 GAPDH/S100A9/COTL1 3 GO:0051965 positive regulation of synapse assembly 3/969 60/18722 0.606742111237703 0.772521037304936 DLG5/CLSTN1/TPBG 3 GO:1903670 regulation of sprouting angiogenesis 3/969 60/18722 0.606742111237703 0.772521037304936 SEMA6A/PKM/EPN2 3 GO:0050868 negative regulation of T cell activation 6/969 122/18722 0.60935777450657 0.772521037304936 DLG5/ANXA1/DLG1/GLI3/LGALS3/PAWR 6 GO:0000422 autophagy of mitochondrion 4/969 81/18722 0.609539989521887 0.772521037304936 VPS13C/HUWE1/RB1CC1/VDAC1 4 GO:0051149 positive regulation of muscle cell differentiation 4/969 81/18722 0.609539989521887 0.772521037304936 MORF4L2/MMP14/DDX39B/MAPK14 4 GO:0061726 mitochondrion disassembly 4/969 81/18722 0.609539989521887 0.772521037304936 VPS13C/HUWE1/RB1CC1/VDAC1 4 GO:0006672 ceramide metabolic process 5/969 102/18722 0.613256770081962 0.772521037304936 ORMDL1/PLPP3/ITGB8/B4GALT5/HEXA 5 GO:0035710 CD4-positive, alpha-beta T cell activation 5/969 102/18722 0.613256770081962 0.772521037304936 ANXA1/CTSL/FOXP1/GATA3/STOML2 5 GO:0062014 negative regulation of small molecule metabolic process 5/969 102/18722 0.613256770081962 0.772521037304936 PARP1/ATP2B4/NCOR1/EP300/REST 5 GO:1902106 negative regulation of leukocyte differentiation 5/969 102/18722 0.613256770081962 0.772521037304936 FBN1/ANXA1/CDK6/GLI3/PIK3R1 5 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 13/969 264/18722 0.613481668132014 0.772521037304936 EGFR/CAV1/APP/MIF/IQGAP1/IGF2/IL6ST/ISL1/NRP1/RICTOR/CSH1/CD24/HES1 13 GO:0070555 response to interleukin-1 7/969 143/18722 0.614167337362751 0.772521037304936 APP/ANXA1/EGR1/RPS6KA5/USP10/YY1/TAF9 7 GO:0001946 lymphangiogenesis 1/969 18/18722 0.615976877621444 0.772521037304936 PTPN14 1 GO:0002223 stimulatory C-type lectin receptor signaling pathway 1/969 18/18722 0.615976877621444 0.772521037304936 EP300 1 GO:0002283 neutrophil activation involved in immune response 1/969 18/18722 0.615976877621444 0.772521037304936 ANXA3 1 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 1/969 18/18722 0.615976877621444 0.772521037304936 CD46 1 GO:0006085 acetyl-CoA biosynthetic process 1/969 18/18722 0.615976877621444 0.772521037304936 ACSS1 1 GO:0006103 2-oxoglutarate metabolic process 1/969 18/18722 0.615976877621444 0.772521037304936 IDH1 1 GO:0006415 translational termination 1/969 18/18722 0.615976877621444 0.772521037304936 EIF5A 1 GO:0006595 polyamine metabolic process 1/969 18/18722 0.615976877621444 0.772521037304936 OAZ1 1 GO:0015936 coenzyme A metabolic process 1/969 18/18722 0.615976877621444 0.772521037304936 CROT 1 GO:0019184 nonribosomal peptide biosynthetic process 1/969 18/18722 0.615976877621444 0.772521037304936 GCLM 1 GO:0019896 axonal transport of mitochondrion 1/969 18/18722 0.615976877621444 0.772521037304936 ARMCX3 1 GO:0021511 spinal cord patterning 1/969 18/18722 0.615976877621444 0.772521037304936 GLI3 1 GO:0030206 chondroitin sulfate biosynthetic process 1/969 18/18722 0.615976877621444 0.772521037304936 CHPF 1 GO:0030730 sequestering of triglyceride 1/969 18/18722 0.615976877621444 0.772521037304936 PLIN2 1 GO:0030889 negative regulation of B cell proliferation 1/969 18/18722 0.615976877621444 0.772521037304936 PAWR 1 GO:0031649 heat generation 1/969 18/18722 0.615976877621444 0.772521037304936 ADRB1 1 GO:0032095 regulation of response to food 1/969 18/18722 0.615976877621444 0.772521037304936 NUCB2 1 GO:0032634 interleukin-5 production 1/969 18/18722 0.615976877621444 0.772521037304936 GATA3 1 GO:0032674 regulation of interleukin-5 production 1/969 18/18722 0.615976877621444 0.772521037304936 GATA3 1 GO:0033189 response to vitamin A 1/969 18/18722 0.615976877621444 0.772521037304936 DNMT3A 1 GO:0034162 toll-like receptor 9 signaling pathway 1/969 18/18722 0.615976877621444 0.772521037304936 RTN4 1 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 1/969 18/18722 0.615976877621444 0.772521037304936 GATA3 1 GO:0036507 protein demannosylation 1/969 18/18722 0.615976877621444 0.772521037304936 MAN1A2 1 GO:0036508 protein alpha-1,2-demannosylation 1/969 18/18722 0.615976877621444 0.772521037304936 MAN1A2 1 GO:0042136 neurotransmitter biosynthetic process 1/969 18/18722 0.615976877621444 0.772521037304936 SLC6A4 1 GO:0043217 myelin maintenance 1/969 18/18722 0.615976877621444 0.772521037304936 PLEC 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep 1/969 18/18722 0.615976877621444 0.772521037304936 ADRB1 1 GO:0045623 negative regulation of T-helper cell differentiation 1/969 18/18722 0.615976877621444 0.772521037304936 ANXA1 1 GO:0045653 negative regulation of megakaryocyte differentiation 1/969 18/18722 0.615976877621444 0.772521037304936 PRMT1 1 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/969 18/18722 0.615976877621444 0.772521037304936 SERPINB9 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/969 18/18722 0.615976877621444 0.772521037304936 SYT7 1 GO:0048643 positive regulation of skeletal muscle tissue development 1/969 18/18722 0.615976877621444 0.772521037304936 IGF2 1 GO:0051382 kinetochore assembly 1/969 18/18722 0.615976877621444 0.772521037304936 CENPN 1 GO:0051447 negative regulation of meiotic cell cycle 1/969 18/18722 0.615976877621444 0.772521037304936 DUSP1 1 GO:0055070 copper ion homeostasis 1/969 18/18722 0.615976877621444 0.772521037304936 APP 1 GO:0060192 negative regulation of lipase activity 1/969 18/18722 0.615976877621444 0.772521037304936 ANXA1 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/969 18/18722 0.615976877621444 0.772521037304936 PARP1 1 GO:0060457 negative regulation of digestive system process 1/969 18/18722 0.615976877621444 0.772521037304936 WNK1 1 GO:0060546 negative regulation of necroptotic process 1/969 18/18722 0.615976877621444 0.772521037304936 CAV1 1 GO:0060973 cell migration involved in heart development 1/969 18/18722 0.615976877621444 0.772521037304936 BMP7 1 GO:0071071 regulation of phospholipid biosynthetic process 1/969 18/18722 0.615976877621444 0.772521037304936 IDH1 1 GO:0071318 cellular response to ATP 1/969 18/18722 0.615976877621444 0.772521037304936 HSP90B1 1 GO:0071800 podosome assembly 1/969 18/18722 0.615976877621444 0.772521037304936 RHOA 1 GO:0072189 ureter development 1/969 18/18722 0.615976877621444 0.772521037304936 GATA3 1 GO:0097709 connective tissue replacement 1/969 18/18722 0.615976877621444 0.772521037304936 ROCK1 1 GO:0150078 positive regulation of neuroinflammatory response 1/969 18/18722 0.615976877621444 0.772521037304936 CTSC 1 GO:0150079 negative regulation of neuroinflammatory response 1/969 18/18722 0.615976877621444 0.772521037304936 GRN 1 GO:1902001 fatty acid transmembrane transport 1/969 18/18722 0.615976877621444 0.772521037304936 SLC2A1 1 GO:1902683 regulation of receptor localization to synapse 1/969 18/18722 0.615976877621444 0.772521037304936 DAG1 1 GO:1905820 positive regulation of chromosome separation 1/969 18/18722 0.615976877621444 0.772521037304936 ANAPC11 1 GO:1990840 response to lectin 1/969 18/18722 0.615976877621444 0.772521037304936 EP300 1 GO:1990858 cellular response to lectin 1/969 18/18722 0.615976877621444 0.772521037304936 EP300 1 GO:2000641 regulation of early endosome to late endosome transport 1/969 18/18722 0.615976877621444 0.772521037304936 EZR 1 GO:0060997 dendritic spine morphogenesis 3/969 61/18722 0.618011201565201 0.774886405801282 CFL1/PPP1R9A/CDC42 3 GO:0006310 DNA recombination 15/969 305/18722 0.618253613507839 0.77500440973662 FUS/PRKDC/HMGB3/RIF1/PARP1/NIPBL/SETD2/RAD50/TFRC/YY1/SETX/SUPT6H/SFPQ/KPNA2/TPRKB 15 GO:0050806 positive regulation of synaptic transmission 8/969 164/18722 0.61886371322992 0.775465997476878 EGFR/APP/PPP1R9A/KIF5B/EIF2AK4/CLSTN1/MME/VAMP2 8 GO:0002714 positive regulation of B cell mediated immunity 2/969 40/18722 0.620402475210644 0.775465997476878 RIF1/TFRC 2 GO:0002891 positive regulation of immunoglobulin mediated immune response 2/969 40/18722 0.620402475210644 0.775465997476878 RIF1/TFRC 2 GO:0009069 serine family amino acid metabolic process 2/969 40/18722 0.620402475210644 0.775465997476878 GLDC/GCLM 2 GO:0010863 positive regulation of phospholipase C activity 2/969 40/18722 0.620402475210644 0.775465997476878 EGFR/GNAQ 2 GO:0031297 replication fork processing 2/969 40/18722 0.620402475210644 0.775465997476878 BOD1L1/ATRX 2 GO:0032094 response to food 2/969 40/18722 0.620402475210644 0.775465997476878 PLEC/NUCB2 2 GO:0055069 zinc ion homeostasis 2/969 40/18722 0.620402475210644 0.775465997476878 SLC39A10/S100A9 2 GO:0097352 autophagosome maturation 2/969 40/18722 0.620402475210644 0.775465997476878 CALM1/UVRAG 2 GO:0150077 regulation of neuroinflammatory response 2/969 40/18722 0.620402475210644 0.775465997476878 GRN/CTSC 2 GO:1901223 negative regulation of NIK/NF-kappaB signaling 2/969 40/18722 0.620402475210644 0.775465997476878 TMSB4X/BMP7 2 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 2/969 40/18722 0.620402475210644 0.775465997476878 NFAT5/RHOA 2 GO:0014065 phosphatidylinositol 3-kinase signaling 7/969 144/18722 0.621509730408724 0.776242293970115 EGFR/ZFP36L1/IGF1R/NF1/PIK3R1/PLXNB1/GATA3 7 GO:0031644 regulation of nervous system process 7/969 144/18722 0.621509730408724 0.776242293970115 AKAP9/APP/DAG1/CTSC/DICER1/SLC9A1/HOMER1 7 GO:0019395 fatty acid oxidation 5/969 103/18722 0.621914750258873 0.776242293970115 CROT/SLC27A2/MAPK14/HADHA/ETFA 5 GO:0030004 cellular monovalent inorganic cation homeostasis 5/969 103/18722 0.621914750258873 0.776242293970115 GRN/SLC9A1/ATP6V0E1/TM9SF4/ATP6AP2 5 GO:0032760 positive regulation of tumor necrosis factor production 5/969 103/18722 0.621914750258873 0.776242293970115 APP/MIF/HSPB1/ISL1/PIK3R1 5 GO:0046425 regulation of receptor signaling pathway via JAK-STAT 5/969 103/18722 0.621914750258873 0.776242293970115 CAV1/PRLR/CSH1/AKR1B1/HES1 5 GO:0001909 leukocyte mediated cytotoxicity 6/969 124/18722 0.625199833452938 0.780156239165485 SERPINB9/PRDX1/CTSC/CADM1/KIF5B/TUBB4B 6 GO:0007286 spermatid development 8/969 165/18722 0.625702652464324 0.78059729333458 DYNLL1/JAM3/AFF4/SMARCA2/CELF1/QKI/TMF1/CDYL 8 GO:0043367 CD4-positive, alpha-beta T cell differentiation 4/969 83/18722 0.628821440350557 0.780904709104563 ANXA1/CTSL/FOXP1/GATA3 4 GO:0061053 somite development 4/969 83/18722 0.628821440350557 0.780904709104563 PRKDC/RBBP6/EP300/RBPJ 4 GO:0009311 oligosaccharide metabolic process 3/969 62/18722 0.629059167779567 0.780904709104563 GAA/MANBA/FUT8 3 GO:0010573 vascular endothelial growth factor production 3/969 62/18722 0.629059167779567 0.780904709104563 ADGRG1/IL6ST/ISL1 3 GO:0032615 interleukin-12 production 3/969 62/18722 0.629059167779567 0.780904709104563 ISL1/FOXP1/MAPK14 3 GO:0032655 regulation of interleukin-12 production 3/969 62/18722 0.629059167779567 0.780904709104563 ISL1/FOXP1/MAPK14 3 GO:0032757 positive regulation of interleukin-8 production 3/969 62/18722 0.629059167779567 0.780904709104563 HSPA1A/DDIT3/HSPA1B 3 GO:0045428 regulation of nitric oxide biosynthetic process 3/969 62/18722 0.629059167779567 0.780904709104563 CAV1/DYNLL1/ATP2B4 3 GO:0048002 antigen processing and presentation of peptide antigen 3/969 62/18722 0.629059167779567 0.780904709104563 CTSL/CTSD/CTSV 3 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 3/969 62/18722 0.629059167779567 0.780904709104563 LRP1/CSNK2B/BMP7 3 GO:0070265 necrotic cell death 3/969 62/18722 0.629059167779567 0.780904709104563 CAV1/CFLAR/PYGL 3 GO:0007099 centriole replication 2/969 41/18722 0.633901754428614 0.780904709104563 NPM1/CEP152 2 GO:0032735 positive regulation of interleukin-12 production 2/969 41/18722 0.633901754428614 0.780904709104563 ISL1/MAPK14 2 GO:0050691 regulation of defense response to virus by host 2/969 41/18722 0.633901754428614 0.780904709104563 TRIM44/EIF2AK4 2 GO:1905521 regulation of macrophage migration 2/969 41/18722 0.633901754428614 0.780904709104563 MIF/MMP14 2 GO:2000008 regulation of protein localization to cell surface 2/969 41/18722 0.633901754428614 0.780904709104563 TM9SF4/GOPC 2 GO:0002281 macrophage activation involved in immune response 1/969 19/18722 0.635872001957673 0.780904709104563 GRN 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/969 19/18722 0.635872001957673 0.780904709104563 SERPINB9 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/969 19/18722 0.635872001957673 0.780904709104563 ADRB1 1 GO:0006044 N-acetylglucosamine metabolic process 1/969 19/18722 0.635872001957673 0.780904709104563 EXTL2 1 GO:0006071 glycerol metabolic process 1/969 19/18722 0.635872001957673 0.780904709104563 TPI1 1 GO:0006309 apoptotic DNA fragmentation 1/969 19/18722 0.635872001957673 0.780904709104563 DICER1 1 GO:0006670 sphingosine metabolic process 1/969 19/18722 0.635872001957673 0.780904709104563 PLPP3 1 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 1/969 19/18722 0.635872001957673 0.780904709104563 GNAQ 1 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 1/969 19/18722 0.635872001957673 0.780904709104563 IMPDH2 1 GO:0009226 nucleotide-sugar biosynthetic process 1/969 19/18722 0.635872001957673 0.780904709104563 NANS 1 GO:0010738 regulation of protein kinase A signaling 1/969 19/18722 0.635872001957673 0.780904709104563 MIF 1 GO:0010885 regulation of cholesterol storage 1/969 19/18722 0.635872001957673 0.780904709104563 ABCA1 1 GO:0015802 basic amino acid transport 1/969 19/18722 0.635872001957673 0.780904709104563 SLC7A6 1 GO:0019373 epoxygenase P450 pathway 1/969 19/18722 0.635872001957673 0.780904709104563 CYP2J2 1 GO:0030050 vesicle transport along actin filament 1/969 19/18722 0.635872001957673 0.780904709104563 ACTN4 1 GO:0031065 positive regulation of histone deacetylation 1/969 19/18722 0.635872001957673 0.780904709104563 NIPBL 1 GO:0032011 ARF protein signal transduction 1/969 19/18722 0.635872001957673 0.780904709104563 ARFGEF1 1 GO:0032012 regulation of ARF protein signal transduction 1/969 19/18722 0.635872001957673 0.780904709104563 ARFGEF1 1 GO:0032026 response to magnesium ion 1/969 19/18722 0.635872001957673 0.780904709104563 ANK3 1 GO:0032616 interleukin-13 production 1/969 19/18722 0.635872001957673 0.780904709104563 GATA3 1 GO:0032656 regulation of interleukin-13 production 1/969 19/18722 0.635872001957673 0.780904709104563 GATA3 1 GO:0034501 protein localization to kinetochore 1/969 19/18722 0.635872001957673 0.780904709104563 CDK1 1 GO:0038092 nodal signaling pathway 1/969 19/18722 0.635872001957673 0.780904709104563 CITED2 1 GO:0042474 middle ear morphogenesis 1/969 19/18722 0.635872001957673 0.780904709104563 NAGLU 1 GO:0042776 mitochondrial ATP synthesis coupled proton transport 1/969 19/18722 0.635872001957673 0.780904709104563 STOML2 1 GO:0043031 negative regulation of macrophage activation 1/969 19/18722 0.635872001957673 0.780904709104563 GRN 1 GO:0044827 modulation by host of viral genome replication 1/969 19/18722 0.635872001957673 0.780904709104563 EIF2AK4 1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/969 19/18722 0.635872001957673 0.780904709104563 MPHOSPH8 1 GO:0045603 positive regulation of endothelial cell differentiation 1/969 19/18722 0.635872001957673 0.780904709104563 BTG1 1 GO:0045618 positive regulation of keratinocyte differentiation 1/969 19/18722 0.635872001957673 0.780904709104563 NCOA3 1 GO:0045821 positive regulation of glycolytic process 1/969 19/18722 0.635872001957673 0.780904709104563 APP 1 GO:0046033 AMP metabolic process 1/969 19/18722 0.635872001957673 0.780904709104563 AK2 1 GO:0046782 regulation of viral transcription 1/969 19/18722 0.635872001957673 0.780904709104563 RSF1 1 GO:0048245 eosinophil chemotaxis 1/969 19/18722 0.635872001957673 0.780904709104563 LGALS3 1 GO:0050961 detection of temperature stimulus involved in sensory perception 1/969 19/18722 0.635872001957673 0.780904709104563 NR2F6 1 GO:0051546 keratinocyte migration 1/969 19/18722 0.635872001957673 0.780904709104563 FERMT1 1 GO:0051571 positive regulation of histone H3-K4 methylation 1/969 19/18722 0.635872001957673 0.780904709104563 RTF1 1 GO:0051957 positive regulation of amino acid transport 1/969 19/18722 0.635872001957673 0.780904709104563 ITGB1 1 GO:0062099 negative regulation of programmed necrotic cell death 1/969 19/18722 0.635872001957673 0.780904709104563 CAV1 1 GO:0070233 negative regulation of T cell apoptotic process 1/969 19/18722 0.635872001957673 0.780904709104563 DOCK8 1 GO:0070989 oxidative demethylation 1/969 19/18722 0.635872001957673 0.780904709104563 TET2 1 GO:0072074 kidney mesenchyme development 1/969 19/18722 0.635872001957673 0.780904709104563 BMP7 1 GO:0097501 stress response to metal ion 1/969 19/18722 0.635872001957673 0.780904709104563 HSPA5 1 GO:0097623 potassium ion export across plasma membrane 1/969 19/18722 0.635872001957673 0.780904709104563 DLG1 1 GO:0140131 positive regulation of lymphocyte chemotaxis 1/969 19/18722 0.635872001957673 0.780904709104563 WNK1 1 GO:1903083 protein localization to condensed chromosome 1/969 19/18722 0.635872001957673 0.780904709104563 CDK1 1 GO:1903204 negative regulation of oxidative stress-induced neuron death 1/969 19/18722 0.635872001957673 0.780904709104563 REST 1 GO:1903975 regulation of glial cell migration 1/969 19/18722 0.635872001957673 0.780904709104563 LRP1 1 GO:2000042 negative regulation of double-strand break repair via homologous recombination 1/969 19/18722 0.635872001957673 0.780904709104563 RIF1 1 GO:2000369 regulation of clathrin-dependent endocytosis 1/969 19/18722 0.635872001957673 0.780904709104563 AAK1 1 GO:0045580 regulation of T cell differentiation 7/969 146/18722 0.635960666274209 0.780904709104563 CD46/SOX4/ANXA1/GLI3/RHOA/XBP1/GATA3 7 GO:0009117 nucleotide metabolic process 24/969 489/18722 0.636308594306627 0.781148394138228 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0010660 regulation of muscle cell apoptotic process 4/969 84/18722 0.63823050596235 0.783323772700621 PPP1R10/BMP7/CFLAR/HMOX1 4 GO:0000041 transition metal ion transport 5/969 105/18722 0.638879296915598 0.783935948739355 FTH1/SLC39A10/CLTC/TFRC/SLC40A1 5 GO:0009451 RNA modification 8/969 167/18722 0.639178784301851 0.784064681453812 RBM47/ZC3H13/ADAR/RNMT/NHP2/NOP10/SSB/TPRKB 8 GO:0001756 somitogenesis 3/969 63/18722 0.639884398469289 0.784064681453812 PRKDC/EP300/RBPJ 3 GO:0001947 heart looping 3/969 63/18722 0.639884398469289 0.784064681453812 TBX3/AHI1/CITED2 3 GO:0002704 negative regulation of leukocyte mediated immunity 3/969 63/18722 0.639884398469289 0.784064681453812 CD46/SERPINB9/HMOX1 3 GO:0099601 regulation of neurotransmitter receptor activity 3/969 63/18722 0.639884398469289 0.784064681453812 AKAP9/APP/HOMER1 3 GO:2000242 negative regulation of reproductive process 3/969 63/18722 0.639884398469289 0.784064681453812 GJA1/DUSP1/BMP7 3 GO:1903531 negative regulation of secretion by cell 7/969 147/18722 0.643066585327297 0.787779178368601 GJA1/ANXA1/FRMD4A/PPP1R9A/REST/HMOX1/VAMP3 7 GO:0002833 positive regulation of response to biotic stimulus 8/969 168/18722 0.6458137361628 0.790228083094659 GRN/PRKDC/PUM1/CADM1/ANKRD17/PUM2/EP300/SFPQ 8 GO:0010677 negative regulation of cellular carbohydrate metabolic process 2/969 42/18722 0.647022271952773 0.790228083094659 NCOR1/EP300 2 GO:0010939 regulation of necrotic cell death 2/969 42/18722 0.647022271952773 0.790228083094659 CAV1/CFLAR 2 GO:0014003 oligodendrocyte development 2/969 42/18722 0.647022271952773 0.790228083094659 GSTP1/B4GALT5 2 GO:0021575 hindbrain morphogenesis 2/969 42/18722 0.647022271952773 0.790228083094659 HSPA5/HES1 2 GO:0032689 negative regulation of interferon-gamma production 2/969 42/18722 0.647022271952773 0.790228083094659 DDIT3/GATA3 2 GO:0032691 negative regulation of interleukin-1 beta production 2/969 42/18722 0.647022271952773 0.790228083094659 GSTP1/SERPINB1 2 GO:0042168 heme metabolic process 2/969 42/18722 0.647022271952773 0.790228083094659 NFE2L1/HMOX1 2 GO:0045047 protein targeting to ER 2/969 42/18722 0.647022271952773 0.790228083094659 HSPA5/SEC62 2 GO:0046596 regulation of viral entry into host cell 2/969 42/18722 0.647022271952773 0.790228083094659 LY6E/P4HB 2 GO:0060999 positive regulation of dendritic spine development 2/969 42/18722 0.647022271952773 0.790228083094659 DLG5/PPP1R9A 2 GO:1900274 regulation of phospholipase C activity 2/969 42/18722 0.647022271952773 0.790228083094659 EGFR/GNAQ 2 GO:0019216 regulation of lipid metabolic process 16/969 331/18722 0.647160070241984 0.790228083094659 CAV1/SF1/ANXA1/ORMDL1/EGR1/PSAP/NCOR1/SORBS1/MBTPS1/IDH1/CDC42/REST/EDF1/DNAJC15/NPC2/STOML2 16 GO:1903707 negative regulation of hemopoiesis 5/969 106/18722 0.64718258623137 0.790228083094659 FBN1/ANXA1/CDK6/GLI3/PIK3R1 5 GO:0019221 cytokine-mediated signaling pathway 23/969 472/18722 0.648258520687859 0.790951869963145 KRT8/CSF3R/CAV1/KRT18/IL6ST/EGR1/GSTP1/TRIM44/TMSB4X/PRLR/HSPA1A/CSNK2B/RPS6KA5/ADAR/EIF5A/WNK1/ACTN4/P4HB/NFKBIA/HSPA1B/KRAS/CD24/CASP4 23 GO:0002429 immune response-activating cell surface receptor signaling pathway 14/969 291/18722 0.649375488186828 0.790951869963145 SLC39A10/RPS3/PHPT1/KCNN4/PDE4B/FOXP1/LGALS3/PAWR/WNK1/EP300/SPPL3/GATA3/EZR/STOML2 14 GO:0002757 immune response-activating signal transduction 14/969 291/18722 0.649375488186828 0.790951869963145 SLC39A10/RPS3/PHPT1/KCNN4/PDE4B/FOXP1/LGALS3/PAWR/WNK1/EP300/SPPL3/GATA3/EZR/STOML2 14 GO:0044272 sulfur compound biosynthetic process 7/969 148/18722 0.650091207831601 0.790951869963145 SLC26A2/ACSS1/GSTP1/CHPF/MTR/B3GNT2/GCLM 7 GO:0006940 regulation of smooth muscle contraction 3/969 64/18722 0.65048574394172 0.790951869963145 ATP2B1/CAV1/RHOA 3 GO:0016126 sterol biosynthetic process 3/969 64/18722 0.65048574394172 0.790951869963145 DHCR24/MBTPS1/CYB5R1 3 GO:0046530 photoreceptor cell differentiation 3/969 64/18722 0.65048574394172 0.790951869963145 TUG1/AHI1/NAGLU 3 GO:0080164 regulation of nitric oxide metabolic process 3/969 64/18722 0.65048574394172 0.790951869963145 CAV1/DYNLL1/ATP2B4 3 GO:1903409 reactive oxygen species biosynthetic process 3/969 64/18722 0.65048574394172 0.790951869963145 SLC5A3/RHOA/CFLAR 3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1/969 20/18722 0.654737426226668 0.790951869963145 BRD4 1 GO:0001832 blastocyst growth 1/969 20/18722 0.654737426226668 0.790951869963145 RTF1 1 GO:0002115 store-operated calcium entry 1/969 20/18722 0.654737426226668 0.790951869963145 HOMER1 1 GO:0006448 regulation of translational elongation 1/969 20/18722 0.654737426226668 0.790951869963145 EIF5A 1 GO:0006525 arginine metabolic process 1/969 20/18722 0.654737426226668 0.790951869963145 ATP2B4 1 GO:0006590 thyroid hormone generation 1/969 20/18722 0.654737426226668 0.790951869963145 GATA3 1 GO:0006837 serotonin transport 1/969 20/18722 0.654737426226668 0.790951869963145 SLC6A4 1 GO:0006883 cellular sodium ion homeostasis 1/969 20/18722 0.654737426226668 0.790951869963145 SLC9A1 1 GO:0007194 negative regulation of adenylate cyclase activity 1/969 20/18722 0.654737426226668 0.790951869963145 AKAP9 1 GO:0007620 copulation 1/969 20/18722 0.654737426226668 0.790951869963145 SLC6A4 1 GO:0009713 catechol-containing compound biosynthetic process 1/969 20/18722 0.654737426226668 0.790951869963145 GATA3 1 GO:0014047 glutamate secretion 1/969 20/18722 0.654737426226668 0.790951869963145 GJA1 1 GO:0021516 dorsal spinal cord development 1/969 20/18722 0.654737426226668 0.790951869963145 LMO4 1 GO:0030150 protein import into mitochondrial matrix 1/969 20/18722 0.654737426226668 0.790951869963145 DNAJC15 1 GO:0031645 negative regulation of nervous system process 1/969 20/18722 0.654737426226668 0.790951869963145 CTSC 1 GO:0032332 positive regulation of chondrocyte differentiation 1/969 20/18722 0.654737426226668 0.790951869963145 GLI3 1 GO:0032793 positive regulation of CREB transcription factor activity 1/969 20/18722 0.654737426226668 0.790951869963145 RPS6KA5 1 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 1/969 20/18722 0.654737426226668 0.790951869963145 MPHOSPH8 1 GO:0042423 catecholamine biosynthetic process 1/969 20/18722 0.654737426226668 0.790951869963145 GATA3 1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process 1/969 20/18722 0.654737426226668 0.790951869963145 AGO2 1 GO:0043046 DNA methylation involved in gamete generation 1/969 20/18722 0.654737426226668 0.790951869963145 DNMT3A 1 GO:0043691 reverse cholesterol transport 1/969 20/18722 0.654737426226668 0.790951869963145 ABCA1 1 GO:0043984 histone H4-K16 acetylation 1/969 20/18722 0.654737426226668 0.790951869963145 PHF20 1 GO:0045063 T-helper 1 cell differentiation 1/969 20/18722 0.654737426226668 0.790951869963145 ANXA1 1 GO:0045844 positive regulation of striated muscle tissue development 1/969 20/18722 0.654737426226668 0.790951869963145 IGF2 1 GO:0046629 gamma-delta T cell activation 1/969 20/18722 0.654737426226668 0.790951869963145 SOX4 1 GO:0048636 positive regulation of muscle organ development 1/969 20/18722 0.654737426226668 0.790951869963145 IGF2 1 GO:0048670 regulation of collateral sprouting 1/969 20/18722 0.654737426226668 0.790951869963145 LRP1 1 GO:0060231 mesenchymal to epithelial transition 1/969 20/18722 0.654737426226668 0.790951869963145 GATA3 1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway 1/969 20/18722 0.654737426226668 0.790951869963145 ADAR 1 GO:0070932 histone H3 deacetylation 1/969 20/18722 0.654737426226668 0.790951869963145 SFPQ 1 GO:0071625 vocalization behavior 1/969 20/18722 0.654737426226668 0.790951869963145 GLI3 1 GO:1901386 negative regulation of voltage-gated calcium channel activity 1/969 20/18722 0.654737426226668 0.790951869963145 CALM1 1 GO:1990182 exosomal secretion 1/969 20/18722 0.654737426226668 0.790951869963145 RAB11A 1 GO:2000010 positive regulation of protein localization to cell surface 1/969 20/18722 0.654737426226668 0.790951869963145 TM9SF4 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/969 20/18722 0.654737426226668 0.790951869963145 ATP2B4 1 GO:2000757 negative regulation of peptidyl-lysine acetylation 1/969 20/18722 0.654737426226668 0.790951869963145 ZNF451 1 GO:0051341 regulation of oxidoreductase activity 5/969 107/18722 0.655364660410768 0.791343741983981 EGFR/CAV1/ATP2B4/CALM1/KRAS 5 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 5/969 107/18722 0.655364660410768 0.791343741983981 APP/MIF/HSPB1/ISL1/PIK3R1 5 GO:0042180 cellular ketone metabolic process 10/969 211/18722 0.657666355421502 0.793939564202534 CAV1/TPI1/ANXA1/CYP11A1/EGR1/ATP2B4/NCOR1/AKR1B1/NMT1/REST 10 GO:0002861 regulation of inflammatory response to antigenic stimulus 2/969 43/18722 0.659767031614897 0.795373127386263 GPX1/MAPK14 2 GO:0009268 response to pH 2/969 43/18722 0.659767031614897 0.795373127386263 GJA1/SLC9A1 2 GO:0034661 ncRNA catabolic process 2/969 43/18722 0.659767031614897 0.795373127386263 KCNQ1OT1/DICER1 2 GO:0045776 negative regulation of blood pressure 2/969 43/18722 0.659767031614897 0.795373127386263 ADRB1/GJA5 2 GO:0046636 negative regulation of alpha-beta T cell activation 2/969 43/18722 0.659767031614897 0.795373127386263 ANXA1/GLI3 2 GO:1903793 positive regulation of anion transport 2/969 43/18722 0.659767031614897 0.795373127386263 TCAF1/ITGB1 2 GO:0006487 protein N-linked glycosylation 3/969 65/18722 0.660862488209757 0.796326346180353 RPN2/FUT8/OST4 3 GO:0070613 regulation of protein processing 3/969 65/18722 0.660862488209757 0.796326346180353 GLG1/ENO1/MMP14 3 GO:0006164 purine nucleotide biosynthetic process 9/969 191/18722 0.661056866276372 0.796376944020359 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0002832 negative regulation of response to biotic stimulus 5/969 108/18722 0.663424311476923 0.798860703174747 GRN/SERPINB9/ADAR/PCBP2/HTRA1 5 GO:0034440 lipid oxidation 5/969 108/18722 0.663424311476923 0.798860703174747 CROT/SLC27A2/MAPK14/HADHA/ETFA 5 GO:0046890 regulation of lipid biosynthetic process 8/969 171/18722 0.665294137086379 0.799260009890947 SF1/ANXA1/ORMDL1/EGR1/SORBS1/MBTPS1/IDH1/REST 8 GO:0051048 negative regulation of secretion 8/969 171/18722 0.665294137086379 0.799260009890947 GJA1/ANXA1/FRMD4A/PPP1R9A/WNK1/REST/HMOX1/VAMP3 8 GO:0016101 diterpenoid metabolic process 4/969 87/18722 0.665512106206814 0.799260009890947 EGFR/LRP2/LRP1/AKR1B1 4 GO:0002768 immune response-regulating cell surface receptor signaling pathway 15/969 315/18722 0.667397907722898 0.799260009890947 SLC39A10/RPS3/PHPT1/KCNN4/PDE4B/FOXP1/LGALS3/PAWR/WNK1/EP300/SPPL3/GATA3/CD24/EZR/STOML2 15 GO:0006753 nucleoside phosphate metabolic process 24/969 497/18722 0.667439719907535 0.799260009890947 GAPDH/SLC26A2/ALDOA/LDHA/APP/TPI1/CROT/PKM/ENO1/ACSS1/DLG1/TMSB4X/PARP1/RAN/PDE4B/RHOA/NCOR1/TPST2/EP300/PGAM1/STOML2/PGK1/IMPDH2/AK2 24 GO:0042093 T-helper cell differentiation 3/969 66/18722 0.671014321842122 0.799260009890947 ANXA1/FOXP1/GATA3 3 GO:1902476 chloride transmembrane transport 3/969 66/18722 0.671014321842122 0.799260009890947 SLC26A2/GABRE/PCYOX1 3 GO:1905953 negative regulation of lipid localization 3/969 66/18722 0.671014321842122 0.799260009890947 ITGAV/ABCA1/NFKBIA 3 GO:0048515 spermatid differentiation 8/969 172/18722 0.671643178801801 0.799260009890947 DYNLL1/JAM3/AFF4/SMARCA2/CELF1/QKI/TMF1/CDYL 8 GO:0006775 fat-soluble vitamin metabolic process 2/969 44/18722 0.672139740558259 0.799260009890947 LRP2/CYP11A1 2 GO:0032007 negative regulation of TOR signaling 2/969 44/18722 0.672139740558259 0.799260009890947 ITFG2/PDCD6 2 GO:0042269 regulation of natural killer cell mediated cytotoxicity 2/969 44/18722 0.672139740558259 0.799260009890947 SERPINB9/CADM1 2 GO:0042554 superoxide anion generation 2/969 44/18722 0.672139740558259 0.799260009890947 EGFR/GSTP1 2 GO:0001502 cartilage condensation 1/969 21/18722 0.672626391791119 0.799260009890947 MAPK14 1 GO:0003091 renal water homeostasis 1/969 21/18722 0.672626391791119 0.799260009890947 AKR1B1 1 GO:0006067 ethanol metabolic process 1/969 21/18722 0.672626391791119 0.799260009890947 ACSS1 1 GO:0007252 I-kappaB phosphorylation 1/969 21/18722 0.672626391791119 0.799260009890947 ERC1 1 GO:0007289 spermatid nucleus differentiation 1/969 21/18722 0.672626391791119 0.799260009890947 TMF1 1 GO:0007617 mating behavior 1/969 21/18722 0.672626391791119 0.799260009890947 APP 1 GO:0009067 aspartate family amino acid biosynthetic process 1/969 21/18722 0.672626391791119 0.799260009890947 MTR 1 GO:0009127 purine nucleoside monophosphate biosynthetic process 1/969 21/18722 0.672626391791119 0.799260009890947 IMPDH2 1 GO:0010766 negative regulation of sodium ion transport 1/969 21/18722 0.672626391791119 0.799260009890947 WNK1 1 GO:0010878 cholesterol storage 1/969 21/18722 0.672626391791119 0.799260009890947 ABCA1 1 GO:0019985 translesion synthesis 1/969 21/18722 0.672626391791119 0.799260009890947 USP10 1 GO:0022010 central nervous system myelination 1/969 21/18722 0.672626391791119 0.799260009890947 B4GALT5 1 GO:0023019 signal transduction involved in regulation of gene expression 1/969 21/18722 0.672626391791119 0.799260009890947 PARP1 1 GO:0030449 regulation of complement activation 1/969 21/18722 0.672626391791119 0.799260009890947 CD46 1 GO:0030502 negative regulation of bone mineralization 1/969 21/18722 0.672626391791119 0.799260009890947 LTBP3 1 GO:0032291 axon ensheathment in central nervous system 1/969 21/18722 0.672626391791119 0.799260009890947 B4GALT5 1 GO:0032482 Rab protein signal transduction 1/969 21/18722 0.672626391791119 0.799260009890947 DENND4C 1 GO:0033630 positive regulation of cell adhesion mediated by integrin 1/969 21/18722 0.672626391791119 0.799260009890947 FERMT1 1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 1/969 21/18722 0.672626391791119 0.799260009890947 WASF2 1 GO:0034471 ncRNA 5'-end processing 1/969 21/18722 0.672626391791119 0.799260009890947 SSB 1 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 1/969 21/18722 0.672626391791119 0.799260009890947 CTSL 1 GO:0043576 regulation of respiratory gaseous exchange 1/969 21/18722 0.672626391791119 0.799260009890947 SLC5A3 1 GO:0044342 type B pancreatic cell proliferation 1/969 21/18722 0.672626391791119 0.799260009890947 SERPINB1 1 GO:0046514 ceramide catabolic process 1/969 21/18722 0.672626391791119 0.799260009890947 HEXA 1 GO:0046519 sphingoid metabolic process 1/969 21/18722 0.672626391791119 0.799260009890947 PLPP3 1 GO:0046597 negative regulation of viral entry into host cell 1/969 21/18722 0.672626391791119 0.799260009890947 LY6E 1 GO:0046599 regulation of centriole replication 1/969 21/18722 0.672626391791119 0.799260009890947 NPM1 1 GO:0048199 vesicle targeting, to, from or within Golgi 1/969 21/18722 0.672626391791119 0.799260009890947 PDCD6 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/969 21/18722 0.672626391791119 0.799260009890947 DAG1 1 GO:0050802 circadian sleep/wake cycle, sleep 1/969 21/18722 0.672626391791119 0.799260009890947 ADRB1 1 GO:0050849 negative regulation of calcium-mediated signaling 1/969 21/18722 0.672626391791119 0.799260009890947 ATP2B4 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/969 21/18722 0.672626391791119 0.799260009890947 GSTP1 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/969 21/18722 0.672626391791119 0.799260009890947 GSTP1 1 GO:0060117 auditory receptor cell development 1/969 21/18722 0.672626391791119 0.799260009890947 TRIOBP 1 GO:0070269 pyroptosis 1/969 21/18722 0.672626391791119 0.799260009890947 CASP4 1 GO:0070584 mitochondrion morphogenesis 1/969 21/18722 0.672626391791119 0.799260009890947 PLEC 1 GO:0071498 cellular response to fluid shear stress 1/969 21/18722 0.672626391791119 0.799260009890947 PLEC 1 GO:0071605 monocyte chemotactic protein-1 production 1/969 21/18722 0.672626391791119 0.799260009890947 GSTP1 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/969 21/18722 0.672626391791119 0.799260009890947 GSTP1 1 GO:0090141 positive regulation of mitochondrial fission 1/969 21/18722 0.672626391791119 0.799260009890947 AURKA 1 GO:0097734 extracellular exosome biogenesis 1/969 21/18722 0.672626391791119 0.799260009890947 RAB11A 1 GO:0098719 sodium ion import across plasma membrane 1/969 21/18722 0.672626391791119 0.799260009890947 SLC9A1 1 GO:0150146 cell junction disassembly 1/969 21/18722 0.672626391791119 0.799260009890947 PIK3R1 1 GO:1901863 positive regulation of muscle tissue development 1/969 21/18722 0.672626391791119 0.799260009890947 IGF2 1 GO:1903429 regulation of cell maturation 1/969 21/18722 0.672626391791119 0.799260009890947 AURKA 1 GO:0008643 carbohydrate transport 7/969 152/18722 0.67735630444487 0.804697441925185 SLC2A1/SLC5A3/PIK3R1/SORBS1/MAPK14/SLC35B4/EZR 7 GO:0010469 regulation of signaling receptor activity 8/969 173/18722 0.677918701694557 0.80518253069449 AKAP9/APP/ITGB1/NCOA3/NRP1/LY6E/LRPAP1/HOMER1 8 GO:1904659 glucose transmembrane transport 5/969 110/18722 0.679172320511408 0.806488195181235 SLC2A1/SLC5A3/PIK3R1/SORBS1/MAPK14 5 GO:0042130 negative regulation of T cell proliferation 3/969 67/18722 0.680941315703959 0.80767120196752 DLG5/DLG1/PAWR 3 GO:0046635 positive regulation of alpha-beta T cell activation 3/969 67/18722 0.680941315703959 0.80767120196752 ANXA1/GLI3/RHOA 3 GO:0048814 regulation of dendrite morphogenesis 3/969 67/18722 0.680941315703959 0.80767120196752 CUX1/OBSL1/ID1 3 GO:0050435 amyloid-beta metabolic process 3/969 67/18722 0.680941315703959 0.80767120196752 ROCK1/MME/RTN4 3 GO:0061371 determination of heart left/right asymmetry 3/969 67/18722 0.680941315703959 0.80767120196752 TBX3/AHI1/CITED2 3 GO:0010657 muscle cell apoptotic process 4/969 89/18722 0.682901153049819 0.80981198680244 PPP1R10/BMP7/CFLAR/HMOX1 4 GO:0006903 vesicle targeting 2/969 45/18722 0.68414472853842 0.810550975139828 TRIP11/PDCD6 2 GO:0010824 regulation of centrosome duplication 2/969 45/18722 0.68414472853842 0.810550975139828 NPM1/XPO1 2 GO:0042551 neuron maturation 2/969 45/18722 0.68414472853842 0.810550975139828 APP/B4GALT5 2 GO:0098534 centriole assembly 2/969 45/18722 0.68414472853842 0.810550975139828 NPM1/CEP152 2 GO:0031349 positive regulation of defense response 13/969 278/18722 0.686244588384143 0.81166534938283 NEAT1/EGFR/APP/GRN/PRKDC/GJA1/IL6ST/CTSC/CADM1/S100A9/EP300/NFKBIA/SFPQ 13 GO:0002053 positive regulation of mesenchymal cell proliferation 1/969 22/18722 0.689589389831566 0.81166534938283 LRP5 1 GO:0002089 lens morphogenesis in camera-type eye 1/969 22/18722 0.689589389831566 0.81166534938283 CITED2 1 GO:0002220 innate immune response activating cell surface receptor signaling pathway 1/969 22/18722 0.689589389831566 0.81166534938283 EP300 1 GO:0006359 regulation of transcription by RNA polymerase III 1/969 22/18722 0.689589389831566 0.81166534938283 CHD8 1 GO:0006662 glycerol ether metabolic process 1/969 22/18722 0.689589389831566 0.81166534938283 TXN 1 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 1/969 22/18722 0.689589389831566 0.81166534938283 SPESP1 1 GO:0016137 glycoside metabolic process 1/969 22/18722 0.689589389831566 0.81166534938283 AKR1B1 1 GO:0021904 dorsal/ventral neural tube patterning 1/969 22/18722 0.689589389831566 0.81166534938283 GLI3 1 GO:0022616 DNA strand elongation 1/969 22/18722 0.689589389831566 0.81166534938283 RAD50 1 GO:0032098 regulation of appetite 1/969 22/18722 0.689589389831566 0.81166534938283 NUCB2 1 GO:0032700 negative regulation of interleukin-17 production 1/969 22/18722 0.689589389831566 0.81166534938283 DDIT3 1 GO:0032727 positive regulation of interferon-alpha production 1/969 22/18722 0.689589389831566 0.81166534938283 SETD2 1 GO:0033617 mitochondrial cytochrome c oxidase assembly 1/969 22/18722 0.689589389831566 0.81166534938283 COX20 1 GO:0034755 iron ion transmembrane transport 1/969 22/18722 0.689589389831566 0.81166534938283 SLC40A1 1 GO:0035809 regulation of urine volume 1/969 22/18722 0.689589389831566 0.81166534938283 AKR1B1 1 GO:0042749 regulation of circadian sleep/wake cycle 1/969 22/18722 0.689589389831566 0.81166534938283 ADRB1 1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 1/969 22/18722 0.689589389831566 0.81166534938283 ANXA1 1 GO:0045540 regulation of cholesterol biosynthetic process 1/969 22/18722 0.689589389831566 0.81166534938283 MBTPS1 1 GO:0045624 positive regulation of T-helper cell differentiation 1/969 22/18722 0.689589389831566 0.81166534938283 ANXA1 1 GO:0046058 cAMP metabolic process 1/969 22/18722 0.689589389831566 0.81166534938283 PDE4B 1 GO:0051151 negative regulation of smooth muscle cell differentiation 1/969 22/18722 0.689589389831566 0.81166534938283 ANKRD17 1 GO:0055093 response to hyperoxia 1/969 22/18722 0.689589389831566 0.81166534938283 CAV1 1 GO:0061042 vascular wound healing 1/969 22/18722 0.689589389831566 0.81166534938283 XBP1 1 GO:0071467 cellular response to pH 1/969 22/18722 0.689589389831566 0.81166534938283 SLC9A1 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/969 22/18722 0.689589389831566 0.81166534938283 ANK3 1 GO:0090280 positive regulation of calcium ion import 1/969 22/18722 0.689589389831566 0.81166534938283 LGALS3 1 GO:0106118 regulation of sterol biosynthetic process 1/969 22/18722 0.689589389831566 0.81166534938283 MBTPS1 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/969 22/18722 0.689589389831566 0.81166534938283 HMOX1 1 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 3/969 68/18722 0.690643895607286 0.812723485350974 ANXA1/FOXP1/GATA3 3 GO:0035278 miRNA mediated inhibition of translation 4/969 90/18722 0.691354101027826 0.813010020695639 TNRC6B/TNRC6A/EIF4G1/AGO2 4 GO:0040033 negative regulation of translation, ncRNA-mediated 4/969 90/18722 0.691354101027826 0.813010020695639 TNRC6B/TNRC6A/EIF4G1/AGO2 4 GO:0070664 negative regulation of leukocyte proliferation 4/969 90/18722 0.691354101027826 0.813010020695639 DLG5/DLG1/GSTP1/PAWR 4 GO:0009855 determination of bilateral symmetry 6/969 133/18722 0.691689929090954 0.813039039457788 GALNT11/TBX3/AHI1/TMEM107/CITED2/DDIT3 6 GO:0010565 regulation of cellular ketone metabolic process 6/969 133/18722 0.691689929090954 0.813039039457788 CAV1/ANXA1/EGR1/ATP2B4/NCOR1/REST 6 GO:0002821 positive regulation of adaptive immune response 5/969 112/18722 0.694420106585486 0.815881177386635 IL6ST/RIF1/TFRC/EIF2AK4/GATA3 5 GO:0010633 negative regulation of epithelial cell migration 5/969 112/18722 0.694420106585486 0.815881177386635 NR2F2/ATP2B4/CSNK2B/RHOA/TACSTD2 5 GO:0006383 transcription by RNA polymerase III 2/969 46/18722 0.695786873679003 0.816752516138022 BDP1/CHD8 2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 2/969 46/18722 0.695786873679003 0.816752516138022 TENM3/CADM1 2 GO:0032924 activin receptor signaling pathway 2/969 46/18722 0.695786873679003 0.816752516138022 CSNK2B/CITED2 2 GO:0090329 regulation of DNA-dependent DNA replication 2/969 46/18722 0.695786873679003 0.816752516138022 ATRX/STOML2 2 GO:0006665 sphingolipid metabolic process 7/969 155/18722 0.696906790350343 0.817883423842553 ORMDL1/PLPP3/PSAP/ITGB8/HACD3/B4GALT5/HEXA 7 GO:0009799 specification of symmetry 6/969 134/18722 0.698572128552034 0.819469796591005 GALNT11/TBX3/AHI1/TMEM107/CITED2/DDIT3 6 GO:0032147 activation of protein kinase activity 6/969 134/18722 0.698572128552034 0.819469796591005 RPLP1/DLG1/PPIA/PRLR/TXN/WNK1 6 GO:0002275 myeloid cell activation involved in immune response 4/969 91/18722 0.699645633130222 0.82000041377502 GRN/VAMP2/HMOX1/ANXA3 4 GO:0045974 regulation of translation, ncRNA-mediated 4/969 91/18722 0.699645633130222 0.82000041377502 TNRC6B/TNRC6A/EIF4G1/AGO2 4 GO:0098661 inorganic anion transmembrane transport 4/969 91/18722 0.699645633130222 0.82000041377502 SLC26A2/GABRE/SLC13A4/PCYOX1 4 GO:0002287 alpha-beta T cell activation involved in immune response 3/969 69/18722 0.70012281788445 0.82000041377502 ANXA1/FOXP1/GATA3 3 GO:0002293 alpha-beta T cell differentiation involved in immune response 3/969 69/18722 0.70012281788445 0.82000041377502 ANXA1/FOXP1/GATA3 3 GO:0019226 transmission of nerve impulse 3/969 69/18722 0.70012281788445 0.82000041377502 PLEC/ANK3/JAM3 3 GO:0070192 chromosome organization involved in meiotic cell cycle 3/969 69/18722 0.70012281788445 0.82000041377502 ATRX/RAD50/CCNE1 3 GO:0050864 regulation of B cell activation 9/969 198/18722 0.702070509427963 0.821531278430898 MIF/ZFP36L1/SLC39A10/RIF1/TFRC/MMP14/PAWR/XBP1/SUPT6H 9 GO:0051648 vesicle localization 8/969 177/18722 0.702272779319639 0.821531278430898 DYNC1H1/TRIP11/KIF5B/RAB11A/CCDC186/ACTN4/PDCD6/RAB17 8 GO:0000966 RNA 5'-end processing 1/969 23/18722 0.705674303267567 0.821531278430898 SSB 1 GO:0002052 positive regulation of neuroblast proliferation 1/969 23/18722 0.705674303267567 0.821531278430898 GLI3 1 GO:0002758 innate immune response-activating signal transduction 1/969 23/18722 0.705674303267567 0.821531278430898 EP300 1 GO:0003323 type B pancreatic cell development 1/969 23/18722 0.705674303267567 0.821531278430898 CDK6 1 GO:0006929 substrate-dependent cell migration 1/969 23/18722 0.705674303267567 0.821531278430898 NRP1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/969 23/18722 0.705674303267567 0.821531278430898 GSTP1 1 GO:0016578 histone deubiquitination 1/969 23/18722 0.705674303267567 0.821531278430898 USP22 1 GO:0021544 subpallium development 1/969 23/18722 0.705674303267567 0.821531278430898 GLI3 1 GO:0031280 negative regulation of cyclase activity 1/969 23/18722 0.705674303267567 0.821531278430898 AKAP9 1 GO:0034105 positive regulation of tissue remodeling 1/969 23/18722 0.705674303267567 0.821531278430898 ROCK1 1 GO:0034695 response to prostaglandin E 1/969 23/18722 0.705674303267567 0.821531278430898 TGFBR3 1 GO:0035640 exploration behavior 1/969 23/18722 0.705674303267567 0.821531278430898 DPP4 1 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 1/969 23/18722 0.705674303267567 0.821531278430898 CTSL 1 GO:0045723 positive regulation of fatty acid biosynthetic process 1/969 23/18722 0.705674303267567 0.821531278430898 ANXA1 1 GO:0045724 positive regulation of cilium assembly 1/969 23/18722 0.705674303267567 0.821531278430898 ATMIN 1 GO:0045932 negative regulation of muscle contraction 1/969 23/18722 0.705674303267567 0.821531278430898 SRI 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1/969 23/18722 0.705674303267567 0.821531278430898 CHPF 1 GO:0051383 kinetochore organization 1/969 23/18722 0.705674303267567 0.821531278430898 CENPN 1 GO:0051590 positive regulation of neurotransmitter transport 1/969 23/18722 0.705674303267567 0.821531278430898 ITGB1 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/969 23/18722 0.705674303267567 0.821531278430898 MAPK14 1 GO:0060547 negative regulation of necrotic cell death 1/969 23/18722 0.705674303267567 0.821531278430898 CAV1 1 GO:0071218 cellular response to misfolded protein 1/969 23/18722 0.705674303267567 0.821531278430898 DNAJB14 1 GO:0072677 eosinophil migration 1/969 23/18722 0.705674303267567 0.821531278430898 LGALS3 1 GO:0140112 extracellular vesicle biogenesis 1/969 23/18722 0.705674303267567 0.821531278430898 RAB11A 1 GO:1902410 mitotic cytokinetic process 1/969 23/18722 0.705674303267567 0.821531278430898 RHOA 1 GO:0001754 eye photoreceptor cell differentiation 2/969 47/18722 0.707071534231526 0.822059140799545 TUG1/NAGLU 2 GO:0010712 regulation of collagen metabolic process 2/969 47/18722 0.707071534231526 0.822059140799545 ITGB1/SUCO 2 GO:0045581 negative regulation of T cell differentiation 2/969 47/18722 0.707071534231526 0.822059140799545 ANXA1/GLI3 2 GO:0047496 vesicle transport along microtubule 2/969 47/18722 0.707071534231526 0.822059140799545 DYNC1H1/KIF5B 2 GO:0051972 regulation of telomerase activity 2/969 47/18722 0.707071534231526 0.822059140799545 MAP3K4/PTGES3 2 GO:0061001 regulation of dendritic spine morphogenesis 2/969 47/18722 0.707071534231526 0.822059140799545 CFL1/PPP1R9A 2 GO:0006497 protein lipidation 4/969 92/18722 0.707775727131059 0.822511885698669 PGAP1/ABCA1/NMT1/RAB3GAP2 4 GO:0048525 negative regulation of viral process 4/969 92/18722 0.707775727131059 0.822511885698669 PPIA/LY6E/MPHOSPH8/BANF1 4 GO:0008645 hexose transmembrane transport 5/969 114/18722 0.709163506730112 0.823642616403427 SLC2A1/SLC5A3/PIK3R1/SORBS1/MAPK14 5 GO:1904892 regulation of receptor signaling pathway via STAT 5/969 114/18722 0.709163506730112 0.823642616403427 CAV1/PRLR/CSH1/AKR1B1/HES1 5 GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 3/969 70/18722 0.709379145892044 0.823642616403427 RIF1/TFRC/SUPT6H 3 GO:0002548 monocyte chemotaxis 3/969 70/18722 0.709379145892044 0.823642616403427 ANXA1/DUSP1/LGALS3 3 GO:0072522 purine-containing compound biosynthetic process 9/969 200/18722 0.713189788092573 0.827699274388583 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0099003 vesicle-mediated transport in synapse 9/969 200/18722 0.713189788092573 0.827699274388583 ACTG1/ROCK1/KIAA1109/SYT7/RAB11A/STON1/CALM1/CLSTN1/VAMP2 9 GO:0033108 mitochondrial respiratory chain complex assembly 4/969 93/18722 0.715744550020491 0.8304082224288 COX20/NDUFA11/NDUFA13/NDUFA6 4 GO:0042471 ear morphogenesis 5/969 115/18722 0.716345359353658 0.8304082224288 NIPBL/TFAP2A/TRIOBP/NAGLU/GATA3 5 GO:0002715 regulation of natural killer cell mediated immunity 2/969 48/18722 0.718004485917705 0.8304082224288 SERPINB9/CADM1 2 GO:0042908 xenobiotic transport 2/969 48/18722 0.718004485917705 0.8304082224288 SLC2A1/GJA1 2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 2/969 48/18722 0.718004485917705 0.8304082224288 BOD1L1/ATRX 2 GO:0120009 intermembrane lipid transfer 2/969 48/18722 0.718004485917705 0.8304082224288 ABCA1/NPC2 2 GO:1902003 regulation of amyloid-beta formation 2/969 48/18722 0.718004485917705 0.8304082224288 ROCK1/RTN4 2 GO:0045824 negative regulation of innate immune response 3/969 71/18722 0.71841422744769 0.8304082224288 GRN/SERPINB9/ADAR 3 GO:0071230 cellular response to amino acid stimulus 3/969 71/18722 0.71841422744769 0.8304082224288 DNMT3A/XBP1/GCLM 3 GO:0034754 cellular hormone metabolic process 6/969 137/18722 0.718595607928011 0.8304082224288 CYP11A1/DHRS2/EGR1/CYP19A1/AKR1B1/REST 6 GO:0065004 protein-DNA complex assembly 9/969 201/18722 0.718647454132333 0.8304082224288 ATRX/BDP1/NPM1/BRD2/HP1BP3/RSF1/BAZ2A/CENPN/TAF9 9 GO:0000395 mRNA 5'-splice site recognition 1/969 24/18722 0.720926541362316 0.8304082224288 SNRPC 1 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/969 24/18722 0.720926541362316 0.8304082224288 RPS21 1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1/969 24/18722 0.720926541362316 0.8304082224288 SERPINB9 1 GO:0002021 response to dietary excess 1/969 24/18722 0.720926541362316 0.8304082224288 ADRB1 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/969 24/18722 0.720926541362316 0.8304082224288 GATA3 1 GO:0002726 positive regulation of T cell cytokine production 1/969 24/18722 0.720926541362316 0.8304082224288 GATA3 1 GO:0010226 response to lithium ion 1/969 24/18722 0.720926541362316 0.8304082224288 CDH1 1 GO:0016048 detection of temperature stimulus 1/969 24/18722 0.720926541362316 0.8304082224288 NR2F6 1 GO:0022410 circadian sleep/wake cycle process 1/969 24/18722 0.720926541362316 0.8304082224288 ADRB1 1 GO:0033032 regulation of myeloid cell apoptotic process 1/969 24/18722 0.720926541362316 0.8304082224288 ANXA1 1 GO:0035458 cellular response to interferon-beta 1/969 24/18722 0.720926541362316 0.8304082224288 NDUFA13 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/969 24/18722 0.720926541362316 0.8304082224288 PHIP 1 GO:0044321 response to leptin 1/969 24/18722 0.720926541362316 0.8304082224288 LRP2 1 GO:0048641 regulation of skeletal muscle tissue development 1/969 24/18722 0.720926541362316 0.8304082224288 IGF2 1 GO:0051123 RNA polymerase II preinitiation complex assembly 1/969 24/18722 0.720926541362316 0.8304082224288 TAF9 1 GO:0051923 sulfation 1/969 24/18722 0.720926541362316 0.8304082224288 TPST2 1 GO:0060571 morphogenesis of an epithelial fold 1/969 24/18722 0.720926541362316 0.8304082224288 BMP7 1 GO:0071294 cellular response to zinc ion 1/969 24/18722 0.720926541362316 0.8304082224288 PARP1 1 GO:0071577 zinc ion transmembrane transport 1/969 24/18722 0.720926541362316 0.8304082224288 SLC39A10 1 GO:0098743 cell aggregation 1/969 24/18722 0.720926541362316 0.8304082224288 MAPK14 1 GO:1901984 negative regulation of protein acetylation 1/969 24/18722 0.720926541362316 0.8304082224288 ZNF451 1 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1/969 24/18722 0.720926541362316 0.8304082224288 SLC5A3 1 GO:2000310 regulation of NMDA receptor activity 1/969 24/18722 0.720926541362316 0.8304082224288 APP 1 GO:0002831 regulation of response to biotic stimulus 15/969 327/18722 0.721506891509788 0.830893568759399 GRN/PRKDC/SERPINB9/PUM1/TRIM44/CADM1/FOXP1/ANKRD17/PUM2/ADAR/EP300/EIF2AK4/PCBP2/HTRA1/SFPQ 15 GO:0006720 isoprenoid metabolic process 5/969 116/18722 0.723400528444474 0.832707304328375 EGFR/LRP2/LRP1/AKR1B1/NPC2 5 GO:0015749 monosaccharide transmembrane transport 5/969 116/18722 0.723400528444474 0.832707304328375 SLC2A1/SLC5A3/PIK3R1/SORBS1/MAPK14 5 GO:0032640 tumor necrosis factor production 8/969 181/18722 0.725406464283247 0.834648653092084 APP/MIF/HSPB1/ISL1/GSTP1/DICER1/PIK3R1/FOXP1 8 GO:0032680 regulation of tumor necrosis factor production 8/969 181/18722 0.725406464283247 0.834648653092084 APP/MIF/HSPB1/ISL1/GSTP1/DICER1/PIK3R1/FOXP1 8 GO:0001736 establishment of planar polarity 3/969 72/18722 0.727229673197674 0.836104761455544 ZNRF3/RHOA/CDC42 3 GO:0007164 establishment of tissue polarity 3/969 72/18722 0.727229673197674 0.836104761455544 ZNRF3/RHOA/CDC42 3 GO:0050709 negative regulation of protein secretion 3/969 72/18722 0.727229673197674 0.836104761455544 ANXA1/FRMD4A/REST 3 GO:0006778 porphyrin-containing compound metabolic process 2/969 49/18722 0.728591864460113 0.836104761455544 NFE2L1/HMOX1 2 GO:0007602 phototransduction 2/969 49/18722 0.728591864460113 0.836104761455544 GNAQ/NMT1 2 GO:0008206 bile acid metabolic process 2/969 49/18722 0.728591864460113 0.836104761455544 SLC27A2/OSBPL9 2 GO:0009395 phospholipid catabolic process 2/969 49/18722 0.728591864460113 0.836104761455544 PRDX6/IDH1 2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 2/969 49/18722 0.728591864460113 0.836104761455544 CSNK2B/BMP7 2 GO:0032692 negative regulation of interleukin-1 production 2/969 49/18722 0.728591864460113 0.836104761455544 GSTP1/SERPINB1 2 GO:0043457 regulation of cellular respiration 2/969 49/18722 0.728591864460113 0.836104761455544 RHOA/DNAJC15 2 GO:0051445 regulation of meiotic cell cycle 2/969 49/18722 0.728591864460113 0.836104761455544 DUSP1/CDC20 2 GO:1990573 potassium ion import across plasma membrane 2/969 49/18722 0.728591864460113 0.836104761455544 DLG1/WNK1 2 GO:0032479 regulation of type I interferon production 4/969 95/18722 0.73119993636366 0.838698725728024 GAPDH/SETD2/TRIM56/YY1 4 GO:0032606 type I interferon production 4/969 95/18722 0.73119993636366 0.838698725728024 GAPDH/SETD2/TRIM56/YY1 4 GO:0071216 cellular response to biotic stimulus 11/969 246/18722 0.73289587571152 0.838698725728024 HSPA5/GSTP1/PABPN1/PDE4B/RHOA/ABCA1/CCDC47/MAPK14/XBP1/NFKBIA/DDIT3 11 GO:0001964 startle response 1/969 25/18722 0.735389167387555 0.838698725728024 CHD8 1 GO:0007274 neuromuscular synaptic transmission 1/969 25/18722 0.735389167387555 0.838698725728024 ERC1 1 GO:0010447 response to acidic pH 1/969 25/18722 0.735389167387555 0.838698725728024 SLC9A1 1 GO:0030318 melanocyte differentiation 1/969 25/18722 0.735389167387555 0.838698725728024 GLI3 1 GO:0032753 positive regulation of interleukin-4 production 1/969 25/18722 0.735389167387555 0.838698725728024 GATA3 1 GO:0032925 regulation of activin receptor signaling pathway 1/969 25/18722 0.735389167387555 0.838698725728024 CSNK2B 1 GO:0035902 response to immobilization stress 1/969 25/18722 0.735389167387555 0.838698725728024 FOS 1 GO:0042730 fibrinolysis 1/969 25/18722 0.735389167387555 0.838698725728024 ANXA2 1 GO:0045822 negative regulation of heart contraction 1/969 25/18722 0.735389167387555 0.838698725728024 SRI 1 GO:0046835 carbohydrate phosphorylation 1/969 25/18722 0.735389167387555 0.838698725728024 GNPTAB 1 GO:0050951 sensory perception of temperature stimulus 1/969 25/18722 0.735389167387555 0.838698725728024 NR2F6 1 GO:0051291 protein heterooligomerization 1/969 25/18722 0.735389167387555 0.838698725728024 KRT10 1 GO:0051788 response to misfolded protein 1/969 25/18722 0.735389167387555 0.838698725728024 DNAJB14 1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 1/969 25/18722 0.735389167387555 0.838698725728024 MED13 1 GO:0060740 prostate gland epithelium morphogenesis 1/969 25/18722 0.735389167387555 0.838698725728024 BMP7 1 GO:0062149 detection of stimulus involved in sensory perception of pain 1/969 25/18722 0.735389167387555 0.838698725728024 NR2F6 1 GO:0071459 protein localization to chromosome, centromeric region 1/969 25/18722 0.735389167387555 0.838698725728024 CDK1 1 GO:0072202 cell differentiation involved in metanephros development 1/969 25/18722 0.735389167387555 0.838698725728024 LGR4 1 GO:0086013 membrane repolarization during cardiac muscle cell action potential 1/969 25/18722 0.735389167387555 0.838698725728024 YWHAE 1 GO:0090312 positive regulation of protein deacetylation 1/969 25/18722 0.735389167387555 0.838698725728024 NIPBL 1 GO:0090330 regulation of platelet aggregation 1/969 25/18722 0.735389167387555 0.838698725728024 IL6ST 1 GO:0090382 phagosome maturation 1/969 25/18722 0.735389167387555 0.838698725728024 SYT7 1 GO:1901623 regulation of lymphocyte chemotaxis 1/969 25/18722 0.735389167387555 0.838698725728024 WNK1 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/969 25/18722 0.735389167387555 0.838698725728024 IGF2 1 GO:0043299 leukocyte degranulation 3/969 73/18722 0.735827335909489 0.838698725728024 VAMP2/HMOX1/ANXA3 3 GO:0051145 smooth muscle cell differentiation 3/969 73/18722 0.735827335909489 0.838698725728024 TBX3/ANKRD17/HES1 3 GO:0051298 centrosome duplication 3/969 73/18722 0.735827335909489 0.838698725728024 NPM1/CEP152/XPO1 3 GO:0051865 protein autoubiquitination 3/969 73/18722 0.735827335909489 0.838698725728024 HECTD1/RNF213/UBE2A 3 GO:0002819 regulation of adaptive immune response 8/969 183/18722 0.736508971229435 0.839292604370918 CD46/ANXA1/IL6ST/RIF1/TFRC/EIF2AK4/SUPT6H/GATA3 8 GO:0034219 carbohydrate transmembrane transport 5/969 118/18722 0.737131177854394 0.839818516561383 SLC2A1/SLC5A3/PIK3R1/SORBS1/MAPK14 5 GO:0015914 phospholipid transport 4/969 96/18722 0.738687690431934 0.839934398561487 KCNN4/ABCA1/ATP10D/NPC2 4 GO:0042158 lipoprotein biosynthetic process 4/969 96/18722 0.738687690431934 0.839934398561487 PGAP1/ABCA1/NMT1/RAB3GAP2 4 GO:0043648 dicarboxylic acid metabolic process 4/969 96/18722 0.738687690431934 0.839934398561487 IDH1/GCLM/SLC19A1/MDH2 4 GO:0002448 mast cell mediated immunity 2/969 50/18722 0.738840112932865 0.839934398561487 SERPINB9/HMOX1 2 GO:0008089 anterograde axonal transport 2/969 50/18722 0.738840112932865 0.839934398561487 HSPB1/KIF5B 2 GO:0010665 regulation of cardiac muscle cell apoptotic process 2/969 50/18722 0.738840112932865 0.839934398561487 PPP1R10/CFLAR 2 GO:0051646 mitochondrion localization 2/969 50/18722 0.738840112932865 0.839934398561487 ARMCX3/UXT 2 GO:0090102 cochlea development 2/969 50/18722 0.738840112932865 0.839934398561487 GATA3/HES1 2 GO:0099054 presynapse assembly 2/969 50/18722 0.738840112932865 0.839934398561487 APP/EIF4G1 2 GO:1902930 regulation of alcohol biosynthetic process 2/969 50/18722 0.738840112932865 0.839934398561487 MBTPS1/REST 2 GO:0006887 exocytosis 16/969 352/18722 0.739008585701113 0.8399432076716 ANXA1/MIA3/SCIN/EXOC1/SYT7/RAB11A/EXPH5/TRPV6/CALM1/ARFGEF1/REST/VAMP2/HMOX1/ANXA3/VAMP3/RAB25 16 GO:0006066 alcohol metabolic process 16/969 353/18722 0.742972266041587 0.844264636297746 APP/TPI1/CYP11A1/ACSS1/PLPP3/LRP5/DHCR24/SLC5A3/ABCA1/AKR1B1/MBTPS1/IDH1/NFE2L1/RXRA/REST/NPC2 16 GO:0034341 response to interferon-gamma 6/969 141/18722 0.743831559023006 0.84487366386747 GAPDH/RPL13A/ACTG1/KIF5B/CDC42/VAMP3 6 GO:0050921 positive regulation of chemotaxis 6/969 141/18722 0.743831559023006 0.84487366386747 MET/HSPB1/NRP1/TMSB4X/WNK1/TPBG 6 GO:0006721 terpenoid metabolic process 4/969 97/18722 0.746016535624387 0.845349250914389 EGFR/LRP2/LRP1/AKR1B1 4 GO:0010596 negative regulation of endothelial cell migration 4/969 97/18722 0.746016535624387 0.845349250914389 NR2F2/ATP2B4/CSNK2B/RHOA 4 GO:1990868 response to chemokine 4/969 97/18722 0.746016535624387 0.845349250914389 DUSP1/DOCK8/RHOA/WNK1 4 GO:1990869 cellular response to chemokine 4/969 97/18722 0.746016535624387 0.845349250914389 DUSP1/DOCK8/RHOA/WNK1 4 GO:0002253 activation of immune response 17/969 375/18722 0.747561092784158 0.845349250914389 CD46/SLC39A10/PRKDC/RPS3/PHPT1/KCNN4/PDE4B/FOXP1/LGALS3/PAWR/WNK1/EP300/SPPL3/GATA3/SFPQ/EZR/STOML2 17 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 2/969 51/18722 0.748755933588156 0.845349250914389 DNAJC15/NDUFA6 2 GO:0009584 detection of visible light 2/969 51/18722 0.748755933588156 0.845349250914389 GNAQ/NMT1 2 GO:0032964 collagen biosynthetic process 2/969 51/18722 0.748755933588156 0.845349250914389 SUCO/SERPINH1 2 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 2/969 51/18722 0.748755933588156 0.845349250914389 ANXA1/GATA3 2 GO:0071622 regulation of granulocyte chemotaxis 2/969 51/18722 0.748755933588156 0.845349250914389 JAM3/DPP4 2 GO:0001963 synaptic transmission, dopaminergic 1/969 26/18722 0.749103019706187 0.845349250914389 SLC6A4 1 GO:0006706 steroid catabolic process 1/969 26/18722 0.749103019706187 0.845349250914389 CYP19A1 1 GO:0007214 gamma-aminobutyric acid signaling pathway 1/969 26/18722 0.749103019706187 0.845349250914389 GABRE 1 GO:0008535 respiratory chain complex IV assembly 1/969 26/18722 0.749103019706187 0.845349250914389 COX20 1 GO:0015985 energy coupled proton transport, down electrochemical gradient 1/969 26/18722 0.749103019706187 0.845349250914389 STOML2 1 GO:0015986 ATP synthesis coupled proton transport 1/969 26/18722 0.749103019706187 0.845349250914389 STOML2 1 GO:0032682 negative regulation of chemokine production 1/969 26/18722 0.749103019706187 0.845349250914389 GSTP1 1 GO:0045026 plasma membrane fusion 1/969 26/18722 0.749103019706187 0.845349250914389 SPESP1 1 GO:0045672 positive regulation of osteoclast differentiation 1/969 26/18722 0.749103019706187 0.845349250914389 FOS 1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 1/969 26/18722 0.749103019706187 0.845349250914389 CADM1 1 GO:0051560 mitochondrial calcium ion homeostasis 1/969 26/18722 0.749103019706187 0.845349250914389 AFG3L2 1 GO:0060219 camera-type eye photoreceptor cell differentiation 1/969 26/18722 0.749103019706187 0.845349250914389 NAGLU 1 GO:0070102 interleukin-6-mediated signaling pathway 1/969 26/18722 0.749103019706187 0.845349250914389 IL6ST 1 GO:0071425 hematopoietic stem cell proliferation 1/969 26/18722 0.749103019706187 0.845349250914389 N4BP2L2 1 GO:0097186 amelogenesis 1/969 26/18722 0.749103019706187 0.845349250914389 CSF3R 1 GO:1900017 positive regulation of cytokine production involved in inflammatory response 1/969 26/18722 0.749103019706187 0.845349250914389 KPNA6 1 GO:1901071 glucosamine-containing compound metabolic process 1/969 26/18722 0.749103019706187 0.845349250914389 EXTL2 1 GO:1903523 negative regulation of blood circulation 1/969 26/18722 0.749103019706187 0.845349250914389 SRI 1 GO:1905523 positive regulation of macrophage migration 1/969 26/18722 0.749103019706187 0.845349250914389 MMP14 1 GO:2000108 positive regulation of leukocyte apoptotic process 1/969 26/18722 0.749103019706187 0.845349250914389 ANXA1 1 GO:0002700 regulation of production of molecular mediator of immune response 7/969 164/18722 0.750794102327708 0.847074693170251 PRKDC/RIF1/TFRC/XBP1/SUPT6H/GATA3/HMOX1 7 GO:0034121 regulation of toll-like receptor signaling pathway 3/969 75/18722 0.752377816046525 0.848538544155314 CAV1/LGR4/RTN4 3 GO:0071706 tumor necrosis factor superfamily cytokine production 8/969 186/18722 0.752578674351298 0.848538544155314 APP/MIF/HSPB1/ISL1/GSTP1/DICER1/PIK3R1/FOXP1 8 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 8/969 186/18722 0.752578674351298 0.848538544155314 APP/MIF/HSPB1/ISL1/GSTP1/DICER1/PIK3R1/FOXP1 8 GO:0006836 neurotransmitter transport 9/969 208/18722 0.754925108891065 0.851000564940618 ITGB1/SLC38A1/SLC38A2/PPP1R9A/SYT7/MCTP2/CALM1/SLC6A4/VAMP2 9 GO:0002224 toll-like receptor signaling pathway 5/969 121/18722 0.756782179210841 0.85174727884357 CAV1/LGR4/COLEC12/RTN4/NFKBIA 5 GO:0002695 negative regulation of leukocyte activation 8/969 187/18722 0.757779339039179 0.85174727884357 GRN/DLG5/ANXA1/DLG1/GLI3/LGALS3/PAWR/HMOX1 8 GO:0001818 negative regulation of cytokine production 16/969 357/18722 0.758437257002735 0.85174727884357 ATP2B1/ANXA1/LGR4/GSTP1/TMSB4X/ANXA4/DICER1/RPS6KA5/TIA1/SERPINB1/YY1/DDIT3/GATA3/CD24/EZR/HMOX1 16 GO:0002444 myeloid leukocyte mediated immunity 4/969 99/18722 0.760201498345985 0.85174727884357 SERPINB9/VAMP2/HMOX1/ANXA3 4 GO:0007631 feeding behavior 4/969 99/18722 0.760201498345985 0.85174727884357 FOS/APP/EIF2AK4/NPB 4 GO:0021549 cerebellum development 4/969 99/18722 0.760201498345985 0.85174727884357 HSPA5/RERE/NAGLU/UQCRQ 4 GO:0042100 B cell proliferation 4/969 99/18722 0.760201498345985 0.85174727884357 MIF/SLC39A10/TFRC/PAWR 4 GO:0006809 nitric oxide biosynthetic process 3/969 76/18722 0.760335375987113 0.85174727884357 CAV1/DYNLL1/ATP2B4 3 GO:0009123 nucleoside monophosphate metabolic process 3/969 76/18722 0.760335375987113 0.85174727884357 DLG1/IMPDH2/AK2 3 GO:0000737 DNA catabolic process, endonucleolytic 1/969 27/18722 0.762106826611659 0.85174727884357 DICER1 1 GO:0001835 blastocyst hatching 1/969 27/18722 0.762106826611659 0.85174727884357 UBE2A 1 GO:0001958 endochondral ossification 1/969 27/18722 0.762106826611659 0.85174727884357 MMP14 1 GO:0002719 negative regulation of cytokine production involved in immune response 1/969 27/18722 0.762106826611659 0.85174727884357 HMOX1 1 GO:0002825 regulation of T-helper 1 type immune response 1/969 27/18722 0.762106826611659 0.85174727884357 ANXA1 1 GO:0006783 heme biosynthetic process 1/969 27/18722 0.762106826611659 0.85174727884357 NFE2L1 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/969 27/18722 0.762106826611659 0.85174727884357 AGO2 1 GO:0010758 regulation of macrophage chemotaxis 1/969 27/18722 0.762106826611659 0.85174727884357 MIF 1 GO:0010894 negative regulation of steroid biosynthetic process 1/969 27/18722 0.762106826611659 0.85174727884357 REST 1 GO:0015813 L-glutamate transmembrane transport 1/969 27/18722 0.762106826611659 0.85174727884357 ITGB1 1 GO:0016556 mRNA modification 1/969 27/18722 0.762106826611659 0.85174727884357 ZC3H13 1 GO:0018195 peptidyl-arginine modification 1/969 27/18722 0.762106826611659 0.85174727884357 PRMT1 1 GO:0018904 ether metabolic process 1/969 27/18722 0.762106826611659 0.85174727884357 TXN 1 GO:0032967 positive regulation of collagen biosynthetic process 1/969 27/18722 0.762106826611659 0.85174727884357 SUCO 1 GO:0034377 plasma lipoprotein particle assembly 1/969 27/18722 0.762106826611659 0.85174727884357 ABCA1 1 GO:0034505 tooth mineralization 1/969 27/18722 0.762106826611659 0.85174727884357 TFAP2A 1 GO:0035116 embryonic hindlimb morphogenesis 1/969 27/18722 0.762106826611659 0.85174727884357 TBX3 1 GO:0035188 hatching 1/969 27/18722 0.762106826611659 0.85174727884357 UBE2A 1 GO:0035235 ionotropic glutamate receptor signaling pathway 1/969 27/18722 0.762106826611659 0.85174727884357 APP 1 GO:0036075 replacement ossification 1/969 27/18722 0.762106826611659 0.85174727884357 MMP14 1 GO:0042403 thyroid hormone metabolic process 1/969 27/18722 0.762106826611659 0.85174727884357 GATA3 1 GO:0042745 circadian sleep/wake cycle 1/969 27/18722 0.762106826611659 0.85174727884357 ADRB1 1 GO:0045606 positive regulation of epidermal cell differentiation 1/969 27/18722 0.762106826611659 0.85174727884357 NCOA3 1 GO:0046174 polyol catabolic process 1/969 27/18722 0.762106826611659 0.85174727884357 TPI1 1 GO:0046337 phosphatidylethanolamine metabolic process 1/969 27/18722 0.762106826611659 0.85174727884357 PISD 1 GO:0048520 positive regulation of behavior 1/969 27/18722 0.762106826611659 0.85174727884357 GJA1 1 GO:0048873 homeostasis of number of cells within a tissue 1/969 27/18722 0.762106826611659 0.85174727884357 KRAS 1 GO:0060512 prostate gland morphogenesis 1/969 27/18722 0.762106826611659 0.85174727884357 BMP7 1 GO:0071684 organism emergence from protective structure 1/969 27/18722 0.762106826611659 0.85174727884357 UBE2A 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/969 27/18722 0.762106826611659 0.85174727884357 AKAP9 1 GO:1903859 regulation of dendrite extension 1/969 27/18722 0.762106826611659 0.85174727884357 SPAG9 1 GO:0002688 regulation of leukocyte chemotaxis 5/969 122/18722 0.763082367446067 0.852655217505483 MIF/DUSP1/JAM3/WNK1/DPP4 5 GO:0006664 glycolipid metabolic process 4/969 100/18722 0.767059937521476 0.856367279104301 PGAP1/ITGB8/B4GALT5/HEXA 4 GO:0009062 fatty acid catabolic process 4/969 100/18722 0.767059937521476 0.856367279104301 CROT/SLC27A2/HADHA/ETFA 4 GO:0019218 regulation of steroid metabolic process 4/969 100/18722 0.767059937521476 0.856367279104301 SF1/EGR1/MBTPS1/REST 4 GO:0051588 regulation of neurotransmitter transport 4/969 100/18722 0.767059937521476 0.856367279104301 ITGB1/PPP1R9A/MCTP2/CALM1 4 GO:0001541 ovarian follicle development 2/969 53/18722 0.767618136084928 0.856413512734369 MMP14/ZFX 2 GO:0002707 negative regulation of lymphocyte mediated immunity 2/969 53/18722 0.767618136084928 0.856413512734369 CD46/SERPINB9 2 GO:0099172 presynapse organization 2/969 53/18722 0.767618136084928 0.856413512734369 APP/EIF4G1 2 GO:0006367 transcription initiation from RNA polymerase II promoter 3/969 77/18722 0.768084602791043 0.856413512734369 ZNF451/MED13/TAF9 3 GO:0010827 regulation of glucose transmembrane transport 3/969 77/18722 0.768084602791043 0.856413512734369 PIK3R1/SORBS1/MAPK14 3 GO:0032418 lysosome localization 3/969 77/18722 0.768084602791043 0.856413512734369 KIF5B/SPAG9/HMOX1 3 GO:0002706 regulation of lymphocyte mediated immunity 7/969 168/18722 0.772428984926813 0.858550999039882 CD46/SERPINB9/RIF1/CADM1/TFRC/SUPT6H/GATA3 7 GO:2000241 regulation of reproductive process 7/969 168/18722 0.772428984926813 0.858550999039882 GJA1/DUSP1/AGO2/BMP7/CITED2/CDC20/AURKA 7 GO:1903509 liposaccharide metabolic process 4/969 101/18722 0.773764094145979 0.858550999039882 PGAP1/ITGB8/B4GALT5/HEXA 4 GO:0002675 positive regulation of acute inflammatory response 1/969 28/18722 0.774437315245695 0.858550999039882 IL6ST 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/969 28/18722 0.774437315245695 0.858550999039882 YME1L1 1 GO:0006829 zinc ion transport 1/969 28/18722 0.774437315245695 0.858550999039882 SLC39A10 1 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 1/969 28/18722 0.774437315245695 0.858550999039882 LRP1 1 GO:0009065 glutamine family amino acid catabolic process 1/969 28/18722 0.774437315245695 0.858550999039882 ATP2B4 1 GO:0009312 oligosaccharide biosynthetic process 1/969 28/18722 0.774437315245695 0.858550999039882 FUT8 1 GO:0010460 positive regulation of heart rate 1/969 28/18722 0.774437315245695 0.858550999039882 ADRB1 1 GO:0010714 positive regulation of collagen metabolic process 1/969 28/18722 0.774437315245695 0.858550999039882 SUCO 1 GO:0010884 positive regulation of lipid storage 1/969 28/18722 0.774437315245695 0.858550999039882 PLIN2 1 GO:0030262 apoptotic nuclear changes 1/969 28/18722 0.774437315245695 0.858550999039882 DICER1 1 GO:0031342 negative regulation of cell killing 1/969 28/18722 0.774437315245695 0.858550999039882 SERPINB9 1 GO:0032607 interferon-alpha production 1/969 28/18722 0.774437315245695 0.858550999039882 SETD2 1 GO:0032647 regulation of interferon-alpha production 1/969 28/18722 0.774437315245695 0.858550999039882 SETD2 1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1/969 28/18722 0.774437315245695 0.858550999039882 EGFR 1 GO:0044331 cell-cell adhesion mediated by cadherin 1/969 28/18722 0.774437315245695 0.858550999039882 CTNND1 1 GO:0045589 regulation of regulatory T cell differentiation 1/969 28/18722 0.774437315245695 0.858550999039882 CD46 1 GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 1/969 28/18722 0.774437315245695 0.858550999039882 CAV1 1 GO:0060259 regulation of feeding behavior 1/969 28/18722 0.774437315245695 0.858550999039882 EIF2AK4 1 GO:0061082 myeloid leukocyte cytokine production 1/969 28/18722 0.774437315245695 0.858550999039882 HMOX1 1 GO:0071280 cellular response to copper ion 1/969 28/18722 0.774437315245695 0.858550999039882 APP 1 GO:0090200 positive regulation of release of cytochrome c from mitochondria 1/969 28/18722 0.774437315245695 0.858550999039882 PMAIP1 1 GO:1902624 positive regulation of neutrophil migration 1/969 28/18722 0.774437315245695 0.858550999039882 CD99 1 GO:1903649 regulation of cytoplasmic transport 1/969 28/18722 0.774437315245695 0.858550999039882 EZR 1 GO:1903672 positive regulation of sprouting angiogenesis 1/969 28/18722 0.774437315245695 0.858550999039882 PKM 1 GO:0007368 determination of left/right symmetry 5/969 124/18722 0.775311413101385 0.859324442520554 GALNT11/TBX3/AHI1/TMEM107/CITED2 5 GO:0009064 glutamine family amino acid metabolic process 3/969 78/18722 0.775628280782521 0.859324442520554 ATP2B4/RIMKLB/GCLM 3 GO:0043537 negative regulation of blood vessel endothelial cell migration 3/969 78/18722 0.775628280782521 0.859324442520554 ATP2B4/CSNK2B/RHOA 3 GO:0006968 cellular defense response 2/969 54/18722 0.776578841139195 0.860012931509522 ITGB1/LGALS3BP 2 GO:0010659 cardiac muscle cell apoptotic process 2/969 54/18722 0.776578841139195 0.860012931509522 PPP1R10/CFLAR 2 GO:0031214 biomineral tissue development 7/969 169/18722 0.777616348669148 0.860979457234103 FBN2/ATP2B1/LGR4/ROCK1/TFAP2A/LTBP3/BMP7 7 GO:0034308 primary alcohol metabolic process 4/969 102/18722 0.780315413495531 0.863758320383443 CYP11A1/ACSS1/AKR1B1/REST 4 GO:0002237 response to molecule of bacterial origin 16/969 363/18722 0.780456714284466 0.863758320383443 JUN/FOS/JUND/GJA1/GSTP1/PABPN1/S100A9/PDE4B/RHOA/ABCA1/FOXP1/MAPK14/XBP1/NFKBIA/CD24/HPGD 16 GO:0007259 receptor signaling pathway via JAK-STAT 7/969 170/18722 0.782715785148406 0.866075099128853 CAV1/IL6ST/ISL1/PRLR/CSH1/AKR1B1/HES1 7 GO:0032496 response to lipopolysaccharide 15/969 343/18722 0.78456443729255 0.866885066771309 JUN/FOS/JUND/GJA1/GSTP1/PABPN1/S100A9/PDE4B/RHOA/ABCA1/FOXP1/MAPK14/XBP1/NFKBIA/HPGD 15 GO:0002067 glandular epithelial cell differentiation 2/969 55/18722 0.785235694930913 0.866885066771309 CDK6/HES1 2 GO:0045620 negative regulation of lymphocyte differentiation 2/969 55/18722 0.785235694930913 0.866885066771309 ANXA1/GLI3 2 GO:0002068 glandular epithelial cell development 1/969 29/18722 0.78612931489943 0.866885066771309 CDK6 1 GO:0003309 type B pancreatic cell differentiation 1/969 29/18722 0.78612931489943 0.866885066771309 CDK6 1 GO:0006688 glycosphingolipid biosynthetic process 1/969 29/18722 0.78612931489943 0.866885066771309 B4GALT5 1 GO:0007143 female meiotic nuclear division 1/969 29/18722 0.78612931489943 0.866885066771309 AURKA 1 GO:0009310 amine catabolic process 1/969 29/18722 0.78612931489943 0.866885066771309 ATP2B4 1 GO:0010955 negative regulation of protein processing 1/969 29/18722 0.78612931489943 0.866885066771309 GLG1 1 GO:0034311 diol metabolic process 1/969 29/18722 0.78612931489943 0.866885066771309 PLPP3 1 GO:0043153 entrainment of circadian clock by photoperiod 1/969 29/18722 0.78612931489943 0.866885066771309 NR2F6 1 GO:0048265 response to pain 1/969 29/18722 0.78612931489943 0.866885066771309 VWA1 1 GO:0051873 killing by host of symbiont cells 1/969 29/18722 0.78612931489943 0.866885066771309 GAPDH 1 GO:0051883 killing of cells in other organism involved in symbiotic interaction 1/969 29/18722 0.78612931489943 0.866885066771309 GAPDH 1 GO:0090025 regulation of monocyte chemotaxis 1/969 29/18722 0.78612931489943 0.866885066771309 DUSP1 1 GO:1903318 negative regulation of protein maturation 1/969 29/18722 0.78612931489943 0.866885066771309 GLG1 1 GO:0031348 negative regulation of defense response 11/969 258/18722 0.786267741388443 0.866885066771309 GRN/SERPINB9/ASH1L/ISL1/GSTP1/GPX1/ADAR/MAPK14/PCBP2/HTRA1/GATA3 11 GO:0030148 sphingolipid biosynthetic process 4/969 103/18722 0.786715440292971 0.867195716298475 ORMDL1/PLPP3/HACD3/B4GALT5 4 GO:0110148 biomineralization 7/969 171/18722 0.78772768476081 0.868128401636439 FBN2/ATP2B1/LGR4/ROCK1/TFAP2A/LTBP3/BMP7 7 GO:1901136 carbohydrate derivative catabolic process 7/969 172/18722 0.792652481983313 0.873306646028658 CTSL/MANBA/GNS/PDE4B/GPC1/HEXA/NAGLU 7 GO:0022600 digestive system process 4/969 104/18722 0.792965811165439 0.873306646028658 KCNN4/COPA/WNK1/EZR 4 GO:0046634 regulation of alpha-beta T cell activation 4/969 104/18722 0.792965811165439 0.873306646028658 ANXA1/GLI3/RHOA/GATA3 4 GO:0015800 acidic amino acid transport 2/969 56/18722 0.793596108302735 0.873306646028658 ITGB1/GJA1 2 GO:0032608 interferon-beta production 2/969 56/18722 0.793596108302735 0.873306646028658 TRIM56/YY1 2 GO:0032648 regulation of interferon-beta production 2/969 56/18722 0.793596108302735 0.873306646028658 TRIM56/YY1 2 GO:0045071 negative regulation of viral genome replication 2/969 56/18722 0.793596108302735 0.873306646028658 MPHOSPH8/BANF1 2 GO:0001523 retinoid metabolic process 3/969 81/18722 0.7970558269576 0.873610832074566 LRP2/LRP1/AKR1B1 3 GO:0001960 negative regulation of cytokine-mediated signaling pathway 3/969 81/18722 0.7970558269576 0.873610832074566 CAV1/GSTP1/ADAR 3 GO:0046209 nitric oxide metabolic process 3/969 81/18722 0.7970558269576 0.873610832074566 CAV1/DYNLL1/ATP2B4 3 GO:2000243 positive regulation of reproductive process 3/969 81/18722 0.7970558269576 0.873610832074566 AGO2/CITED2/AURKA 3 GO:0003299 muscle hypertrophy in response to stress 1/969 30/18722 0.797215854987295 0.873610832074566 ATP2B4 1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/969 30/18722 0.797215854987295 0.873610832074566 DICER1 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/969 30/18722 0.797215854987295 0.873610832074566 APP 1 GO:0008209 androgen metabolic process 1/969 30/18722 0.797215854987295 0.873610832074566 CYP19A1 1 GO:0014887 cardiac muscle adaptation 1/969 30/18722 0.797215854987295 0.873610832074566 ATP2B4 1 GO:0014898 cardiac muscle hypertrophy in response to stress 1/969 30/18722 0.797215854987295 0.873610832074566 ATP2B4 1 GO:0030204 chondroitin sulfate metabolic process 1/969 30/18722 0.797215854987295 0.873610832074566 CHPF 1 GO:0032480 negative regulation of type I interferon production 1/969 30/18722 0.797215854987295 0.873610832074566 YY1 1 GO:0034508 centromere complex assembly 1/969 30/18722 0.797215854987295 0.873610832074566 CENPN 1 GO:0036258 multivesicular body assembly 1/969 30/18722 0.797215854987295 0.873610832074566 RAB11A 1 GO:0036296 response to increased oxygen levels 1/969 30/18722 0.797215854987295 0.873610832074566 CAV1 1 GO:0043304 regulation of mast cell degranulation 1/969 30/18722 0.797215854987295 0.873610832074566 HMOX1 1 GO:0045939 negative regulation of steroid metabolic process 1/969 30/18722 0.797215854987295 0.873610832074566 REST 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/969 30/18722 0.797215854987295 0.873610832074566 EGFR 1 GO:0060292 long-term synaptic depression 1/969 30/18722 0.797215854987295 0.873610832074566 PPP1R9A 1 GO:1903019 negative regulation of glycoprotein metabolic process 1/969 30/18722 0.797215854987295 0.873610832074566 AGO2 1 GO:0006261 DNA-dependent DNA replication 6/969 151/18722 0.799669503586863 0.875932262784521 BOD1L1/ATRX/PURA/HMGA1/STOML2/CCNE1 6 GO:0031497 chromatin assembly 6/969 151/18722 0.799669503586863 0.875932262784521 ATRX/NPM1/BRD2/HP1BP3/RSF1/BAZ2A 6 GO:0006695 cholesterol biosynthetic process 2/969 57/18722 0.801667539637298 0.877569032707272 DHCR24/MBTPS1 2 GO:0034205 amyloid-beta formation 2/969 57/18722 0.801667539637298 0.877569032707272 ROCK1/RTN4 2 GO:1902653 secondary alcohol biosynthetic process 2/969 57/18722 0.801667539637298 0.877569032707272 DHCR24/MBTPS1 2 GO:0006334 nucleosome assembly 5/969 129/18722 0.803758523972775 0.879175153420577 ATRX/NPM1/BRD2/HP1BP3/RSF1 5 GO:0008543 fibroblast growth factor receptor signaling pathway 3/969 82/18722 0.80380766992796 0.879175153420577 GPC1/SETX/GATA3 3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 3/969 82/18722 0.80380766992796 0.879175153420577 RPS21/DICER1/AGO2 3 GO:2001057 reactive nitrogen species metabolic process 3/969 82/18722 0.80380766992796 0.879175153420577 CAV1/DYNLL1/ATP2B4 3 GO:0050871 positive regulation of B cell activation 6/969 152/18722 0.804696073414616 0.879230967744495 MIF/SLC39A10/RIF1/TFRC/MMP14/XBP1 6 GO:0019882 antigen processing and presentation 4/969 106/18722 0.805024547810294 0.879230967744495 CTSL/RAB6A/CTSD/CTSV 4 GO:0002063 chondrocyte development 1/969 31/18722 0.807728257968105 0.879230967744495 SERPINH1 1 GO:0002717 positive regulation of natural killer cell mediated immunity 1/969 31/18722 0.807728257968105 0.879230967744495 CADM1 1 GO:0006613 cotranslational protein targeting to membrane 1/969 31/18722 0.807728257968105 0.879230967744495 SEC62 1 GO:0006779 porphyrin-containing compound biosynthetic process 1/969 31/18722 0.807728257968105 0.879230967744495 NFE2L1 1 GO:0018200 peptidyl-glutamic acid modification 1/969 31/18722 0.807728257968105 0.879230967744495 PARP1 1 GO:0030149 sphingolipid catabolic process 1/969 31/18722 0.807728257968105 0.879230967744495 HEXA 1 GO:0033006 regulation of mast cell activation involved in immune response 1/969 31/18722 0.807728257968105 0.879230967744495 HMOX1 1 GO:0033014 tetrapyrrole biosynthetic process 1/969 31/18722 0.807728257968105 0.879230967744495 NFE2L1 1 GO:0033238 regulation of cellular amine metabolic process 1/969 31/18722 0.807728257968105 0.879230967744495 ATP2B4 1 GO:0034472 snRNA 3'-end processing 1/969 31/18722 0.807728257968105 0.879230967744495 INTS6 1 GO:0036257 multivesicular body organization 1/969 31/18722 0.807728257968105 0.879230967744495 RAB11A 1 GO:0042133 neurotransmitter metabolic process 1/969 31/18722 0.807728257968105 0.879230967744495 SLC6A4 1 GO:0045066 regulatory T cell differentiation 1/969 31/18722 0.807728257968105 0.879230967744495 CD46 1 GO:0045987 positive regulation of smooth muscle contraction 1/969 31/18722 0.807728257968105 0.879230967744495 RHOA 1 GO:0050482 arachidonic acid secretion 1/969 31/18722 0.807728257968105 0.879230967744495 ANXA1 1 GO:0060795 cell fate commitment involved in formation of primary germ layer 1/969 31/18722 0.807728257968105 0.879230967744495 RTF1 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/969 31/18722 0.807728257968105 0.879230967744495 CAV1 1 GO:0065005 protein-lipid complex assembly 1/969 31/18722 0.807728257968105 0.879230967744495 ABCA1 1 GO:0070528 protein kinase C signaling 1/969 31/18722 0.807728257968105 0.879230967744495 ADGRG1 1 GO:0097106 postsynaptic density organization 1/969 31/18722 0.807728257968105 0.879230967744495 DLG1 1 GO:1903963 arachidonate transport 1/969 31/18722 0.807728257968105 0.879230967744495 ANXA1 1 GO:0030534 adult behavior 5/969 130/18722 0.809091790746235 0.880196574866783 APP/PUM1/HOMER1/EPS8/CSTB 5 GO:0007405 neuroblast proliferation 2/969 58/18722 0.809457470112851 0.880196574866783 GLI3/NF1 2 GO:0010043 response to zinc ion 2/969 58/18722 0.809457470112851 0.880196574866783 PARP1/GGH 2 GO:0010574 regulation of vascular endothelial growth factor production 2/969 58/18722 0.809457470112851 0.880196574866783 IL6ST/ISL1 2 GO:0050432 catecholamine secretion 2/969 58/18722 0.809457470112851 0.880196574866783 LY6E/SYT7 2 GO:0050672 negative regulation of lymphocyte proliferation 3/969 83/18722 0.810369653537113 0.881005161095267 DLG5/DLG1/PAWR 3 GO:0050728 negative regulation of inflammatory response 7/969 176/18722 0.81149077185194 0.882040510336572 GRN/ASH1L/ISL1/GSTP1/GPX1/MAPK14/GATA3 7 GO:0006612 protein targeting to membrane 5/969 131/18722 0.814309057546742 0.884737160409422 TCAF1/NACA/HSPA5/ANK3/SEC62 5 GO:0022037 metencephalon development 4/969 108/18722 0.816506284995315 0.884737160409422 HSPA5/RERE/NAGLU/UQCRQ 4 GO:0140053 mitochondrial gene expression 4/969 108/18722 0.816506284995315 0.884737160409422 IARS2/MRPS6/MRPL51/MRPS15 4 GO:0015844 monoamine transport 3/969 84/18722 0.816745177521363 0.884737160409422 LY6E/SYT7/SLC6A4 3 GO:0032945 negative regulation of mononuclear cell proliferation 3/969 84/18722 0.816745177521363 0.884737160409422 DLG5/DLG1/PAWR 3 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2/969 59/18722 0.816973381388053 0.884737160409422 PIK3R1/CDC42 2 GO:0048278 vesicle docking 2/969 59/18722 0.816973381388053 0.884737160409422 CAV2/VAMP3 2 GO:0051055 negative regulation of lipid biosynthetic process 2/969 59/18722 0.816973381388053 0.884737160409422 ORMDL1/REST 2 GO:0051353 positive regulation of oxidoreductase activity 2/969 59/18722 0.816973381388053 0.884737160409422 CALM1/KRAS 2 GO:0006308 DNA catabolic process 1/969 32/18722 0.817696227473691 0.884737160409422 DICER1 1 GO:0006506 GPI anchor biosynthetic process 1/969 32/18722 0.817696227473691 0.884737160409422 PGAP1 1 GO:0019228 neuronal action potential 1/969 32/18722 0.817696227473691 0.884737160409422 ANK3 1 GO:0032196 transposition 1/969 32/18722 0.817696227473691 0.884737160409422 L1TD1 1 GO:0035456 response to interferon-beta 1/969 32/18722 0.817696227473691 0.884737160409422 NDUFA13 1 GO:0042044 fluid transport 1/969 32/18722 0.817696227473691 0.884737160409422 AHCYL1 1 GO:0042219 cellular modified amino acid catabolic process 1/969 32/18722 0.817696227473691 0.884737160409422 PCYOX1 1 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 1/969 32/18722 0.817696227473691 0.884737160409422 ANXA1 1 GO:0045879 negative regulation of smoothened signaling pathway 1/969 32/18722 0.817696227473691 0.884737160409422 GLI3 1 GO:0046475 glycerophospholipid catabolic process 1/969 32/18722 0.817696227473691 0.884737160409422 PRDX6 1 GO:0061036 positive regulation of cartilage development 1/969 32/18722 0.817696227473691 0.884737160409422 GLI3 1 GO:0090140 regulation of mitochondrial fission 1/969 32/18722 0.817696227473691 0.884737160409422 AURKA 1 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 1/969 32/18722 0.817696227473691 0.884737160409422 ANXA1 1 GO:0002456 T cell mediated immunity 4/969 109/18722 0.822035648455744 0.889248250637491 CD46/CTSC/JAG1/GATA3 4 GO:0097194 execution phase of apoptosis 3/969 85/18722 0.822937701729297 0.890039823931562 DICER1/TAOK1/CFLAR 3 GO:0006289 nucleotide-excision repair 2/969 60/18722 0.824222735531168 0.890508169502974 DDB1/XPC 2 GO:0031663 lipopolysaccharide-mediated signaling pathway 2/969 60/18722 0.824222735531168 0.890508169502974 MAPK14/NFKBIA 2 GO:0033866 nucleoside bisphosphate biosynthetic process 2/969 60/18722 0.824222735531168 0.890508169502974 SLC26A2/ACSS1 2 GO:0034030 ribonucleoside bisphosphate biosynthetic process 2/969 60/18722 0.824222735531168 0.890508169502974 SLC26A2/ACSS1 2 GO:0034033 purine nucleoside bisphosphate biosynthetic process 2/969 60/18722 0.824222735531168 0.890508169502974 SLC26A2/ACSS1 2 GO:0017157 regulation of exocytosis 8/969 202/18722 0.826573890251005 0.89120610579434 ANXA1/SYT7/EXPH5/TRPV6/CALM1/REST/VAMP2/HMOX1 8 GO:0006336 DNA replication-independent nucleosome assembly 1/969 33/18722 0.827147931891989 0.89120610579434 ATRX 1 GO:0006505 GPI anchor metabolic process 1/969 33/18722 0.827147931891989 0.89120610579434 PGAP1 1 GO:0006536 glutamate metabolic process 1/969 33/18722 0.827147931891989 0.89120610579434 GCLM 1 GO:0009156 ribonucleoside monophosphate biosynthetic process 1/969 33/18722 0.827147931891989 0.89120610579434 IMPDH2 1 GO:0009648 photoperiodism 1/969 33/18722 0.827147931891989 0.89120610579434 NR2F6 1 GO:0033198 response to ATP 1/969 33/18722 0.827147931891989 0.89120610579434 HSP90B1 1 GO:0040020 regulation of meiotic nuclear division 1/969 33/18722 0.827147931891989 0.89120610579434 CDC20 1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1/969 33/18722 0.827147931891989 0.89120610579434 CDC42 1 GO:0071763 nuclear membrane organization 1/969 33/18722 0.827147931891989 0.89120610579434 NEK6 1 GO:0099084 postsynaptic specialization organization 1/969 33/18722 0.827147931891989 0.89120610579434 DLG1 1 GO:0110110 positive regulation of animal organ morphogenesis 1/969 33/18722 0.827147931891989 0.89120610579434 GATA3 1 GO:0018958 phenol-containing compound metabolic process 4/969 110/18722 0.827426717434776 0.89120610579434 LY6E/EPAS1/AKR1B1/GATA3 4 GO:0030317 flagellated sperm motility 4/969 110/18722 0.827426717434776 0.89120610579434 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0097722 sperm motility 4/969 110/18722 0.827426717434776 0.89120610579434 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0051250 negative regulation of lymphocyte activation 6/969 157/18722 0.828367986907458 0.892036080687899 DLG5/ANXA1/DLG1/GLI3/LGALS3/PAWR 6 GO:0046928 regulation of neurotransmitter secretion 3/969 86/18722 0.828950735846986 0.892295889914799 PPP1R9A/MCTP2/CALM1 3 GO:0060761 negative regulation of response to cytokine stimulus 3/969 86/18722 0.828950735846986 0.892295889914799 CAV1/GSTP1/ADAR 3 GO:0006643 membrane lipid metabolic process 8/969 203/18722 0.830562260356019 0.893846452351844 ORMDL1/PLPP3/PSAP/PGAP1/ITGB8/HACD3/B4GALT5/HEXA 8 GO:0060998 regulation of dendritic spine development 2/969 61/18722 0.83121295702154 0.894362551656283 DLG5/PPP1R9A 2 GO:0046394 carboxylic acid biosynthetic process 13/969 314/18722 0.832189161632966 0.895228604095076 MIF/ANXA1/ACSS1/GPX4/GSTP1/PTGES3/SLC27A2/MTR/ATP2B4/HACD3/XBP1/QKI/OSBPL9 13 GO:0006805 xenobiotic metabolic process 4/969 111/18722 0.832681583338808 0.89557397705878 CYP2J2/GSTO1/GSTP1/GSTA3 4 GO:0097696 receptor signaling pathway via STAT 7/969 181/18722 0.833147117544015 0.895705993887065 CAV1/IL6ST/ISL1/PRLR/CSH1/AKR1B1/HES1 7 GO:0099504 synaptic vesicle cycle 7/969 181/18722 0.833147117544015 0.895705993887065 ACTG1/ROCK1/KIAA1109/SYT7/STON1/CALM1/VAMP2 7 GO:0051262 protein tetramerization 3/969 87/18722 0.834787829762706 0.896861924691403 ALDOA/HOMER1/KRT10 3 GO:0002446 neutrophil mediated immunity 1/969 34/18722 0.836110083638828 0.896861924691403 ANXA3 1 GO:0007616 long-term memory 1/969 34/18722 0.836110083638828 0.896861924691403 EIF2AK4 1 GO:0014072 response to isoquinoline alkaloid 1/969 34/18722 0.836110083638828 0.896861924691403 FOSB 1 GO:0030851 granulocyte differentiation 1/969 34/18722 0.836110083638828 0.896861924691403 CITED2 1 GO:0034724 DNA replication-independent nucleosome organization 1/969 34/18722 0.836110083638828 0.896861924691403 ATRX 1 GO:0035137 hindlimb morphogenesis 1/969 34/18722 0.836110083638828 0.896861924691403 TBX3 1 GO:0043278 response to morphine 1/969 34/18722 0.836110083638828 0.896861924691403 FOSB 1 GO:0050869 negative regulation of B cell activation 1/969 34/18722 0.836110083638828 0.896861924691403 PAWR 1 GO:1904893 negative regulation of receptor signaling pathway via STAT 1/969 34/18722 0.836110083638828 0.896861924691403 CAV1 1 GO:2000352 negative regulation of endothelial cell apoptotic process 1/969 34/18722 0.836110083638828 0.896861924691403 GATA3 1 GO:0002526 acute inflammatory response 4/969 112/18722 0.837802378774117 0.897915543055263 ASH1L/IL6ST/GSTP1/GATA3 4 GO:0032609 interferon-gamma production 4/969 112/18722 0.837802378774117 0.897915543055263 ISL1/PDE4B/DDIT3/GATA3 4 GO:0032649 regulation of interferon-gamma production 4/969 112/18722 0.837802378774117 0.897915543055263 ISL1/PDE4B/DDIT3/GATA3 4 GO:0002260 lymphocyte homeostasis 2/969 62/18722 0.837951416662939 0.897915543055263 RPS6/PMAIP1 2 GO:0007588 excretion 2/969 62/18722 0.837951416662939 0.897915543055263 NFAT5/HMOX1 2 GO:0016053 organic acid biosynthetic process 13/969 316/18722 0.8384982781207 0.898317343472484 MIF/ANXA1/ACSS1/GPX4/GSTP1/PTGES3/SLC27A2/MTR/ATP2B4/HACD3/XBP1/QKI/OSBPL9 13 GO:1903305 regulation of regulated secretory pathway 5/969 136/18722 0.838701438456118 0.898350833648632 SYT7/TRPV6/CALM1/REST/HMOX1 5 GO:0030101 natural killer cell activation 3/969 88/18722 0.840452564546101 0.900042029163509 PBX1/PRDX1/HECTD1 3 GO:0002697 regulation of immune effector process 14/969 339/18722 0.842054583492924 0.901572885337844 CD46/GRN/PRKDC/ANXA1/SERPINB9/RIF1/CADM1/TFRC/ANKRD17/LGALS3/XBP1/SUPT6H/GATA3/HMOX1 14 GO:0002708 positive regulation of lymphocyte mediated immunity 4/969 113/18722 0.842791272370375 0.901992051895879 RIF1/CADM1/TFRC/GATA3 4 GO:0071347 cellular response to interleukin-1 4/969 113/18722 0.842791272370375 0.901992051895879 EGR1/RPS6KA5/USP10/YY1 4 GO:0045143 homologous chromosome segregation 2/969 63/18722 0.844445417259452 0.902089001214749 PTTG1/CCNE1 2 GO:0000731 DNA synthesis involved in DNA repair 1/969 35/18722 0.84460801434056 0.902089001214749 USP10 1 GO:0001569 branching involved in blood vessel morphogenesis 1/969 35/18722 0.84460801434056 0.902089001214749 NRP1 1 GO:0006084 acetyl-CoA metabolic process 1/969 35/18722 0.84460801434056 0.902089001214749 ACSS1 1 GO:0044273 sulfur compound catabolic process 1/969 35/18722 0.84460801434056 0.902089001214749 GNS 1 GO:0045880 positive regulation of smoothened signaling pathway 1/969 35/18722 0.84460801434056 0.902089001214749 DLG5 1 GO:0045922 negative regulation of fatty acid metabolic process 1/969 35/18722 0.84460801434056 0.902089001214749 NCOR1 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process 1/969 35/18722 0.84460801434056 0.902089001214749 CHPF 1 GO:0090181 regulation of cholesterol metabolic process 1/969 35/18722 0.84460801434056 0.902089001214749 MBTPS1 1 GO:1905207 regulation of cardiocyte differentiation 1/969 35/18722 0.84460801434056 0.902089001214749 EGFR 1 GO:0045055 regulated exocytosis 9/969 230/18722 0.847169625173942 0.904640061536376 SCIN/SYT7/TRPV6/CALM1/REST/VAMP2/HMOX1/ANXA3/VAMP3 9 GO:0019751 polyol metabolic process 4/969 114/18722 0.847650463848203 0.904968605530277 TPI1/PLPP3/SLC5A3/AKR1B1 4 GO:0046854 phosphatidylinositol phosphate biosynthetic process 2/969 64/18722 0.850702180914863 0.9068032538296 PIK3R1/SMG1 2 GO:0046888 negative regulation of hormone secretion 2/969 64/18722 0.850702180914863 0.9068032538296 GJA1/REST 2 GO:0048247 lymphocyte chemotaxis 2/969 64/18722 0.850702180914863 0.9068032538296 PLEC/WNK1 2 GO:0070542 response to fatty acid 2/969 64/18722 0.850702180914863 0.9068032538296 GLDC/CCNB1 2 GO:0061097 regulation of protein tyrosine kinase activity 3/969 90/18722 0.851279386878594 0.9068032538296 CAV1/APP/CD24 3 GO:0043279 response to alkaloid 4/969 115/18722 0.852382179325483 0.9068032538296 FOSB/HSPA5/DNMT3A/HOMER1 4 GO:0014046 dopamine secretion 1/969 36/18722 0.85266574613828 0.9068032538296 SYT7 1 GO:0014059 regulation of dopamine secretion 1/969 36/18722 0.85266574613828 0.9068032538296 SYT7 1 GO:0016180 snRNA processing 1/969 36/18722 0.85266574613828 0.9068032538296 INTS6 1 GO:0017004 cytochrome complex assembly 1/969 36/18722 0.85266574613828 0.9068032538296 COX20 1 GO:0038179 neurotrophin signaling pathway 1/969 36/18722 0.85266574613828 0.9068032538296 KIDINS220 1 GO:0044060 regulation of endocrine process 1/969 36/18722 0.85266574613828 0.9068032538296 GJA1 1 GO:0044743 protein transmembrane import into intracellular organelle 1/969 36/18722 0.85266574613828 0.9068032538296 DNAJC15 1 GO:0046466 membrane lipid catabolic process 1/969 36/18722 0.85266574613828 0.9068032538296 HEXA 1 GO:0051955 regulation of amino acid transport 1/969 36/18722 0.85266574613828 0.9068032538296 ITGB1 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/969 36/18722 0.85266574613828 0.9068032538296 ADAR 1 GO:0070306 lens fiber cell differentiation 1/969 36/18722 0.85266574613828 0.9068032538296 KDM5B 1 GO:0086010 membrane depolarization during action potential 1/969 36/18722 0.85266574613828 0.9068032538296 ANK3 1 GO:0097009 energy homeostasis 1/969 36/18722 0.85266574613828 0.9068032538296 EIF4G1 1 GO:0071222 cellular response to lipopolysaccharide 8/969 209/18722 0.853004348198854 0.906978784066574 GSTP1/PABPN1/PDE4B/RHOA/ABCA1/MAPK14/XBP1/NFKBIA 8 GO:0050866 negative regulation of cell activation 8/969 210/18722 0.856502835877765 0.910383266872588 GRN/DLG5/ANXA1/DLG1/GLI3/LGALS3/PAWR/HMOX1 8 GO:0046513 ceramide biosynthetic process 2/969 65/18722 0.856728837826136 0.910383266872588 ORMDL1/B4GALT5 2 GO:0061512 protein localization to cilium 2/969 65/18722 0.856728837826136 0.910383266872588 TMEM107/ARF4 2 GO:0001906 cell killing 7/969 188/18722 0.860099846940496 0.911774379633403 GAPDH/SERPINB9/PRDX1/CTSC/CADM1/KIF5B/TUBB4B 7 GO:0002369 T cell cytokine production 1/969 37/18722 0.860306059313492 0.911774379633403 GATA3 1 GO:0002724 regulation of T cell cytokine production 1/969 37/18722 0.860306059313492 0.911774379633403 GATA3 1 GO:0003016 respiratory system process 1/969 37/18722 0.860306059313492 0.911774379633403 GAA 1 GO:0006904 vesicle docking involved in exocytosis 1/969 37/18722 0.860306059313492 0.911774379633403 VAMP3 1 GO:0007340 acrosome reaction 1/969 37/18722 0.860306059313492 0.911774379633403 SPESP1 1 GO:0016202 regulation of striated muscle tissue development 1/969 37/18722 0.860306059313492 0.911774379633403 IGF2 1 GO:0033260 nuclear DNA replication 1/969 37/18722 0.860306059313492 0.911774379633403 ATRX 1 GO:0043368 positive T cell selection 1/969 37/18722 0.860306059313492 0.911774379633403 CTSL 1 GO:0051954 positive regulation of amine transport 1/969 37/18722 0.860306059313492 0.911774379633403 ITGB1 1 GO:0072529 pyrimidine-containing compound catabolic process 1/969 37/18722 0.860306059313492 0.911774379633403 TET2 1 GO:0090218 positive regulation of lipid kinase activity 1/969 37/18722 0.860306059313492 0.911774379633403 CDC42 1 GO:0097484 dendrite extension 1/969 37/18722 0.860306059313492 0.911774379633403 SPAG9 1 GO:0002702 positive regulation of production of molecular mediator of immune response 4/969 117/18722 0.861472192201298 0.912825157429842 RIF1/TFRC/XBP1/GATA3 4 GO:0030193 regulation of blood coagulation 2/969 66/18722 0.862532416450636 0.913578112762672 CAV1/ANXA2 2 GO:2000272 negative regulation of signaling receptor activity 2/969 66/18722 0.862532416450636 0.913578112762672 LY6E/LRPAP1 2 GO:0002699 positive regulation of immune effector process 9/969 235/18722 0.863764833746036 0.91469807926176 CD46/ANXA1/RIF1/CADM1/TFRC/ANKRD17/XBP1/GATA3/HMOX1 9 GO:0046467 membrane lipid biosynthetic process 5/969 142/18722 0.864435250806168 0.915222573078006 ORMDL1/PLPP3/PGAP1/HACD3/B4GALT5 5 GO:0019217 regulation of fatty acid metabolic process 3/969 93/18722 0.86631735585509 0.916478513821736 CAV1/ANXA1/NCOR1 3 GO:0032755 positive regulation of interleukin-6 production 3/969 93/18722 0.86631735585509 0.916478513821736 APP/ISL1/XBP1 3 GO:0001505 regulation of neurotransmitter levels 8/969 213/18722 0.866597804658186 0.916478513821736 ITGB1/SLC38A1/PPP1R9A/SYT7/MCTP2/CALM1/SLC6A4/VAMP2 8 GO:0000578 embryonic axis specification 1/969 38/18722 0.867550556424823 0.916478513821736 TBX3 1 GO:0002385 mucosal immune response 1/969 38/18722 0.867550556424823 0.916478513821736 RAB17 1 GO:0008210 estrogen metabolic process 1/969 38/18722 0.867550556424823 0.916478513821736 CYP19A1 1 GO:0010719 negative regulation of epithelial to mesenchymal transition 1/969 38/18722 0.867550556424823 0.916478513821736 GATA3 1 GO:0035886 vascular associated smooth muscle cell differentiation 1/969 38/18722 0.867550556424823 0.916478513821736 HES1 1 GO:0046676 negative regulation of insulin secretion 1/969 38/18722 0.867550556424823 0.916478513821736 REST 1 GO:0051930 regulation of sensory perception of pain 1/969 38/18722 0.867550556424823 0.916478513821736 SLC9A1 1 GO:0071398 cellular response to fatty acid 1/969 38/18722 0.867550556424823 0.916478513821736 CCNB1 1 GO:0009583 detection of light stimulus 2/969 67/18722 0.86811983493515 0.916709286193391 GNAQ/NMT1 2 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 2/969 67/18722 0.86811983493515 0.916709286193391 ANXA1/GATA3 2 GO:0044242 cellular lipid catabolic process 8/969 214/18722 0.86983177971925 0.918331491073293 LRP1/CROT/PRDX6/SLC27A2/HEXA/IDH1/HADHA/ETFA 8 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/969 168/18722 0.872373270363242 0.920571610214887 CD46/ANXA1/RIF1/TFRC/SUPT6H/GATA3 6 GO:0009247 glycolipid biosynthetic process 2/969 68/18722 0.873497893702661 0.920571610214887 PGAP1/B4GALT5 2 GO:0031640 killing of cells of other organism 2/969 68/18722 0.873497893702661 0.920571610214887 GAPDH/SERPINB9 2 GO:1900046 regulation of hemostasis 2/969 68/18722 0.873497893702661 0.920571610214887 CAV1/ANXA2 2 GO:1901607 alpha-amino acid biosynthetic process 2/969 68/18722 0.873497893702661 0.920571610214887 MTR/ATP2B4 2 GO:0021587 cerebellum morphogenesis 1/969 39/18722 0.874419723135611 0.920571610214887 HSPA5 1 GO:0032728 positive regulation of interferon-beta production 1/969 39/18722 0.874419723135611 0.920571610214887 TRIM56 1 GO:0045622 regulation of T-helper cell differentiation 1/969 39/18722 0.874419723135611 0.920571610214887 ANXA1 1 GO:0045823 positive regulation of heart contraction 1/969 39/18722 0.874419723135611 0.920571610214887 ADRB1 1 GO:0045923 positive regulation of fatty acid metabolic process 1/969 39/18722 0.874419723135611 0.920571610214887 ANXA1 1 GO:0051931 regulation of sensory perception 1/969 39/18722 0.874419723135611 0.920571610214887 SLC9A1 1 GO:1901861 regulation of muscle tissue development 1/969 39/18722 0.874419723135611 0.920571610214887 IGF2 1 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 1/969 39/18722 0.874419723135611 0.920571610214887 ANXA1 1 GO:2000785 regulation of autophagosome assembly 1/969 39/18722 0.874419723135611 0.920571610214887 RAB3GAP2 1 GO:0002532 production of molecular mediator involved in inflammatory response 3/969 95/18722 0.875583368071469 0.921425429227044 GRN/MAPK14/KPNA6 3 GO:0050764 regulation of phagocytosis 3/969 95/18722 0.875583368071469 0.921425429227044 LRP1/ITGAV/SYT7 3 GO:0007269 neurotransmitter secretion 5/969 145/18722 0.875952110675255 0.921442377292448 PPP1R9A/SYT7/MCTP2/CALM1/VAMP2 5 GO:0099643 signal release from synapse 5/969 145/18722 0.875952110675255 0.921442377292448 PPP1R9A/SYT7/MCTP2/CALM1/VAMP2 5 GO:0006909 phagocytosis 12/969 308/18722 0.878661545793371 0.92374703365877 LRP1/ITGAV/ITGB1/MET/ANXA1/KIAA1109/SYT7/ABCA1/COLEC12/TM9SF4/CDC42/ANXA3 12 GO:0050805 negative regulation of synaptic transmission 2/969 69/18722 0.878673269100219 0.92374703365877 PPP1R9A/SLC6A4 2 GO:0051966 regulation of synaptic transmission, glutamatergic 2/969 69/18722 0.878673269100219 0.92374703365877 EGFR/HOMER1 2 GO:0070374 positive regulation of ERK1 and ERK2 cascade 8/969 217/18722 0.879151409165902 0.924063810197305 EGFR/LRP1/APP/MIF/NRP1/GCNT2/CFLAR/TPBG 8 GO:0042472 inner ear morphogenesis 3/969 96/18722 0.879999357672745 0.924448952676435 TFAP2A/TRIOBP/GATA3 3 GO:0006730 one-carbon metabolic process 1/969 40/18722 0.880932985902917 0.924448952676435 AHCYL1 1 GO:0009187 cyclic nucleotide metabolic process 1/969 40/18722 0.880932985902917 0.924448952676435 PDE4B 1 GO:0010543 regulation of platelet activation 1/969 40/18722 0.880932985902917 0.924448952676435 IL6ST 1 GO:0032892 positive regulation of organic acid transport 1/969 40/18722 0.880932985902917 0.924448952676435 ITGB1 1 GO:0034122 negative regulation of toll-like receptor signaling pathway 1/969 40/18722 0.880932985902917 0.924448952676435 LGR4 1 GO:0042073 intraciliary transport 1/969 40/18722 0.880932985902917 0.924448952676435 PCM1 1 GO:1901661 quinone metabolic process 1/969 40/18722 0.880932985902917 0.924448952676435 AKR1B1 1 GO:0072329 monocarboxylic acid catabolic process 4/969 122/18722 0.882125439417655 0.925514464243459 CROT/SLC27A2/HADHA/ETFA 4 GO:0002251 organ or tissue specific immune response 1/969 41/18722 0.887108766689775 0.92943673109879 RAB17 1 GO:0006418 tRNA aminoacylation for protein translation 1/969 41/18722 0.887108766689775 0.92943673109879 IARS2 1 GO:0032733 positive regulation of interleukin-10 production 1/969 41/18722 0.887108766689775 0.92943673109879 CD46 1 GO:0044786 cell cycle DNA replication 1/969 41/18722 0.887108766689775 0.92943673109879 ATRX 1 GO:0048634 regulation of muscle organ development 1/969 41/18722 0.887108766689775 0.92943673109879 IGF2 1 GO:0050892 intestinal absorption 1/969 41/18722 0.887108766689775 0.92943673109879 EZR 1 GO:1903524 positive regulation of blood circulation 1/969 41/18722 0.887108766689775 0.92943673109879 ADRB1 1 GO:0043550 regulation of lipid kinase activity 2/969 71/18722 0.888442023396959 0.930460523902306 PIK3R1/CDC42 2 GO:0050818 regulation of coagulation 2/969 71/18722 0.888442023396959 0.930460523902306 CAV1/ANXA2 2 GO:0071219 cellular response to molecule of bacterial origin 8/969 221/18722 0.890715151942938 0.932255469792914 GSTP1/PABPN1/PDE4B/RHOA/ABCA1/MAPK14/XBP1/NFKBIA 8 GO:0000266 mitochondrial fission 1/969 42/18722 0.892964534854092 0.932255469792914 AURKA 1 GO:0006040 amino sugar metabolic process 1/969 42/18722 0.892964534854092 0.932255469792914 EXTL2 1 GO:0007212 dopamine receptor signaling pathway 1/969 42/18722 0.892964534854092 0.932255469792914 CAV2 1 GO:0009124 nucleoside monophosphate biosynthetic process 1/969 42/18722 0.892964534854092 0.932255469792914 IMPDH2 1 GO:0009154 purine ribonucleotide catabolic process 1/969 42/18722 0.892964534854092 0.932255469792914 PDE4B 1 GO:0032965 regulation of collagen biosynthetic process 1/969 42/18722 0.892964534854092 0.932255469792914 SUCO 1 GO:0033003 regulation of mast cell activation 1/969 42/18722 0.892964534854092 0.932255469792914 HMOX1 1 GO:0048489 synaptic vesicle transport 1/969 42/18722 0.892964534854092 0.932255469792914 KIF5B 1 GO:0055090 acylglycerol homeostasis 1/969 42/18722 0.892964534854092 0.932255469792914 XBP1 1 GO:0070328 triglyceride homeostasis 1/969 42/18722 0.892964534854092 0.932255469792914 XBP1 1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 1/969 42/18722 0.892964534854092 0.932255469792914 RHOA 1 GO:1904037 positive regulation of epithelial cell apoptotic process 1/969 42/18722 0.892964534854092 0.932255469792914 TIA1 1 GO:0002534 cytokine production involved in inflammatory response 2/969 72/18722 0.89304809054551 0.932255469792914 MAPK14/KPNA6 2 GO:0032729 positive regulation of interferon-gamma production 2/969 72/18722 0.89304809054551 0.932255469792914 ISL1/PDE4B 2 GO:1900015 regulation of cytokine production involved in inflammatory response 2/969 72/18722 0.89304809054551 0.932255469792914 MAPK14/KPNA6 2 GO:0060294 cilium movement involved in cell motility 4/969 125/18722 0.893188506937069 0.932255469792914 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0006641 triglyceride metabolic process 3/969 100/18722 0.896298865742481 0.935315070361462 CAV1/GPX1/SEL1L 3 GO:0055067 monovalent inorganic cation homeostasis 5/969 151/18722 0.896503972747863 0.935342336111067 GRN/SLC9A1/ATP6V0E1/TM9SF4/ATP6AP2 5 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 2/969 73/18722 0.897476844197229 0.93598363356111 EGFR/PTPN12 2 GO:0051937 catecholamine transport 2/969 73/18722 0.897476844197229 0.93598363356111 LY6E/SYT7 2 GO:0034142 toll-like receptor 4 signaling pathway 1/969 43/18722 0.898516856359787 0.936134188862888 NFKBIA 1 GO:0042088 T-helper 1 type immune response 1/969 43/18722 0.898516856359787 0.936134188862888 ANXA1 1 GO:0045494 photoreceptor cell maintenance 1/969 43/18722 0.898516856359787 0.936134188862888 SLC2A1 1 GO:0090278 negative regulation of peptide hormone secretion 1/969 43/18722 0.898516856359787 0.936134188862888 REST 1 GO:0098815 modulation of excitatory postsynaptic potential 1/969 43/18722 0.898516856359787 0.936134188862888 APP 1 GO:0090501 RNA phosphodiester bond hydrolysis 5/969 152/18722 0.899626690412259 0.937103664360069 RPS21/DICER1/PCF11/AGO2/NHP2 5 GO:0033865 nucleoside bisphosphate metabolic process 4/969 128/18722 0.903330188348945 0.93945039148356 SLC26A2/CROT/ACSS1/TPST2 4 GO:0033875 ribonucleoside bisphosphate metabolic process 4/969 128/18722 0.903330188348945 0.93945039148356 SLC26A2/CROT/ACSS1/TPST2 4 GO:0034032 purine nucleoside bisphosphate metabolic process 4/969 128/18722 0.903330188348945 0.93945039148356 SLC26A2/CROT/ACSS1/TPST2 4 GO:0045833 negative regulation of lipid metabolic process 3/969 102/18722 0.903678248866489 0.93945039148356 ORMDL1/NCOR1/REST 3 GO:0002792 negative regulation of peptide secretion 1/969 44/18722 0.903781440448195 0.93945039148356 REST 1 GO:0032620 interleukin-17 production 1/969 44/18722 0.903781440448195 0.93945039148356 DDIT3 1 GO:0032660 regulation of interleukin-17 production 1/969 44/18722 0.903781440448195 0.93945039148356 DDIT3 1 GO:0043039 tRNA aminoacylation 1/969 44/18722 0.903781440448195 0.93945039148356 IARS2 1 GO:0044058 regulation of digestive system process 1/969 44/18722 0.903781440448195 0.93945039148356 WNK1 1 GO:0051150 regulation of smooth muscle cell differentiation 1/969 44/18722 0.903781440448195 0.93945039148356 ANKRD17 1 GO:0002703 regulation of leukocyte mediated immunity 8/969 226/18722 0.90385697825858 0.93945039148356 CD46/SERPINB9/RIF1/CADM1/TFRC/SUPT6H/GATA3/HMOX1 8 GO:0007127 meiosis I 4/969 129/18722 0.906516481608983 0.942027268420868 RAD50/PTTG1/CCNE1/AURKA 4 GO:0019233 sensory perception of pain 3/969 103/18722 0.907187133123695 0.942536770915394 SLC9A1/MME/NR2F6 3 GO:0002920 regulation of humoral immune response 1/969 45/18722 0.90877318390069 0.942685323355499 CD46 1 GO:0032309 icosanoid secretion 1/969 45/18722 0.90877318390069 0.942685323355499 ANXA1 1 GO:0035384 thioester biosynthetic process 1/969 45/18722 0.90877318390069 0.942685323355499 ACSS1 1 GO:0043038 amino acid activation 1/969 45/18722 0.90877318390069 0.942685323355499 IARS2 1 GO:0045910 negative regulation of DNA recombination 1/969 45/18722 0.90877318390069 0.942685323355499 RIF1 1 GO:0046189 phenol-containing compound biosynthetic process 1/969 45/18722 0.90877318390069 0.942685323355499 GATA3 1 GO:0071354 cellular response to interleukin-6 1/969 45/18722 0.90877318390069 0.942685323355499 IL6ST 1 GO:0071616 acyl-CoA biosynthetic process 1/969 45/18722 0.90877318390069 0.942685323355499 ACSS1 1 GO:0008652 cellular amino acid biosynthetic process 2/969 76/18722 0.909758419406008 0.943332837265039 MTR/ATP2B4 2 GO:0032720 negative regulation of tumor necrosis factor production 2/969 76/18722 0.909758419406008 0.943332837265039 GSTP1/DICER1 2 GO:0045089 positive regulation of innate immune response 4/969 131/18722 0.912610912288863 0.945905185105095 PRKDC/CADM1/EP300/SFPQ 4 GO:0006195 purine nucleotide catabolic process 1/969 46/18722 0.913506213016727 0.945905185105095 PDE4B 1 GO:0035094 response to nicotine 1/969 46/18722 0.913506213016727 0.945905185105095 HMOX1 1 GO:0042398 cellular modified amino acid biosynthetic process 1/969 46/18722 0.913506213016727 0.945905185105095 GCLM 1 GO:0043300 regulation of leukocyte degranulation 1/969 46/18722 0.913506213016727 0.945905185105095 HMOX1 1 GO:0046839 phospholipid dephosphorylation 1/969 46/18722 0.913506213016727 0.945905185105095 PLPP3 1 GO:0071827 plasma lipoprotein particle organization 1/969 46/18722 0.913506213016727 0.945905185105095 ABCA1 1 GO:0016079 synaptic vesicle exocytosis 3/969 105/18722 0.913859598547807 0.946073490714301 SYT7/CALM1/VAMP2 3 GO:0009165 nucleotide biosynthetic process 9/969 254/18722 0.914030817951876 0.946073490714301 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0051260 protein homooligomerization 6/969 182/18722 0.914359439359387 0.946226223780625 ALDOA/FUS/MIF/RNF213/SLC1A5/PRMT1 6 GO:0061045 negative regulation of wound healing 2/969 78/18722 0.917165548561351 0.948297340150144 GJA1/ANXA2 2 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 2/969 78/18722 0.917165548561351 0.948297340150144 GSTP1/DICER1 2 GO:0006998 nuclear envelope organization 1/969 47/18722 0.917993923425101 0.948297340150144 NEK6 1 GO:0009261 ribonucleotide catabolic process 1/969 47/18722 0.917993923425101 0.948297340150144 PDE4B 1 GO:0032369 negative regulation of lipid transport 1/969 47/18722 0.917993923425101 0.948297340150144 ITGAV 1 GO:0043114 regulation of vascular permeability 1/969 47/18722 0.917993923425101 0.948297340150144 PLEC 1 GO:0101023 vascular endothelial cell proliferation 1/969 47/18722 0.917993923425101 0.948297340150144 IGF2 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/969 47/18722 0.917993923425101 0.948297340150144 HMOX1 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/969 47/18722 0.917993923425101 0.948297340150144 IGF2 1 GO:1901293 nucleoside phosphate biosynthetic process 9/969 256/18722 0.918267105891409 0.948392074187451 SLC26A2/ALDOA/ENO1/ACSS1/TMSB4X/PARP1/STOML2/IMPDH2/AK2 9 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3/969 107/18722 0.920092810209107 0.950089908348704 RIF1/TFRC/GATA3 3 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 2/969 79/18722 0.920651164605127 0.950290931508275 IGF1R/PLXNB1 2 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 2/969 79/18722 0.920651164605127 0.950290931508275 GAPDH/S100A9 2 GO:0002705 positive regulation of leukocyte mediated immunity 4/969 134/18722 0.921089549201843 0.950555684069674 RIF1/CADM1/TFRC/GATA3 4 GO:0043303 mast cell degranulation 1/969 48/18722 0.922249017840152 0.95137650359902 HMOX1 1 GO:0044458 motile cilium assembly 1/969 48/18722 0.922249017840152 0.95137650359902 ATMIN 1 GO:0061982 meiosis I cell cycle process 4/969 135/18722 0.923747421624185 0.952734167240574 RAD50/PTTG1/CCNE1/AURKA 4 GO:0001913 T cell mediated cytotoxicity 1/969 49/18722 0.926283541868903 0.953886151046425 CTSC 1 GO:0002279 mast cell activation involved in immune response 1/969 49/18722 0.926283541868903 0.953886151046425 HMOX1 1 GO:0009066 aspartate family amino acid metabolic process 1/969 49/18722 0.926283541868903 0.953886151046425 MTR 1 GO:0030195 negative regulation of blood coagulation 1/969 49/18722 0.926283541868903 0.953886151046425 ANXA2 1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1/969 49/18722 0.926283541868903 0.953886151046425 SKP1 1 GO:0042304 regulation of fatty acid biosynthetic process 1/969 49/18722 0.926283541868903 0.953886151046425 ANXA1 1 GO:0070741 response to interleukin-6 1/969 49/18722 0.926283541868903 0.953886151046425 IL6ST 1 GO:0099024 plasma membrane invagination 4/969 136/18722 0.926324572629278 0.953886151046425 RHOA/ABCA1/SNX18/CDC42 4 GO:0008589 regulation of smoothened signaling pathway 2/969 81/18722 0.927212088395541 0.954611972804393 DLG5/GLI3 2 GO:1901617 organic hydroxy compound biosynthetic process 8/969 237/18722 0.928120770274921 0.955359295933964 SLC27A2/DHCR24/AKR1B1/MBTPS1/OSBPL9/REST/GATA3/CYB5R1 8 GO:0007586 digestion 4/969 137/18722 0.928823028896814 0.955705680058033 KCNN4/COPA/WNK1/EZR 4 GO:0060078 regulation of postsynaptic membrane potential 4/969 137/18722 0.928823028896814 0.955705680058033 APP/GABRE/ADRB1/PPP1R9A 4 GO:0015872 dopamine transport 1/969 50/18722 0.930108917969638 0.95571715376998 SYT7 1 GO:0042572 retinol metabolic process 1/969 50/18722 0.930108917969638 0.95571715376998 AKR1B1 1 GO:0060337 type I interferon signaling pathway 1/969 50/18722 0.930108917969638 0.95571715376998 ADAR 1 GO:0071825 protein-lipid complex subunit organization 1/969 50/18722 0.930108917969638 0.95571715376998 ABCA1 1 GO:1900047 negative regulation of hemostasis 1/969 50/18722 0.930108917969638 0.95571715376998 ANXA2 1 GO:0001910 regulation of leukocyte mediated cytotoxicity 2/969 82/18722 0.93029719885723 0.95571715376998 SERPINB9/CADM1 2 GO:0046889 positive regulation of lipid biosynthetic process 2/969 82/18722 0.93029719885723 0.95571715376998 ANXA1/SORBS1 2 GO:0072527 pyrimidine-containing compound metabolic process 2/969 82/18722 0.93029719885723 0.95571715376998 TET2/SLC19A3 2 GO:0001539 cilium or flagellum-dependent cell motility 4/969 138/18722 0.931244787546044 0.956223562885974 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0060285 cilium-dependent cell motility 4/969 138/18722 0.931244787546044 0.956223562885974 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 3/969 111/18722 0.931339061440797 0.956223562885974 EGFR/IGF1R/PLXNB1 3 GO:0001510 RNA methylation 2/969 83/18722 0.933258372815752 0.958005943102557 ZC3H13/RNMT 2 GO:1903307 positive regulation of regulated secretory pathway 1/969 51/18722 0.933735977657268 0.958307977069301 SYT7 1 GO:0019932 second-messenger-mediated signaling 11/969 312/18722 0.93427745234457 0.958675430189029 EGFR/NFAT5/GSTO1/PPP1R9A/ATP2B4/MCTP2/SLC9A1/DMD/CALM1/SPPL3/CALM2 11 GO:0046165 alcohol biosynthetic process 4/969 140/18722 0.935866048096047 0.959980264139968 DHCR24/AKR1B1/MBTPS1/REST 4 GO:0009953 dorsal/ventral pattern formation 2/969 84/18722 0.936100158066834 0.959980264139968 GLI3/DDIT3 2 GO:0042440 pigment metabolic process 2/969 84/18722 0.936100158066834 0.959980264139968 NFE2L1/HMOX1 2 GO:0007129 homologous chromosome pairing at meiosis 1/969 52/18722 0.937174992045898 0.960517063822683 CCNE1 1 GO:0071357 cellular response to type I interferon 1/969 52/18722 0.937174992045898 0.960517063822683 ADAR 1 GO:0072523 purine-containing compound catabolic process 1/969 52/18722 0.937174992045898 0.960517063822683 PDE4B 1 GO:0045088 regulation of innate immune response 7/969 218/18722 0.93831185611948 0.961493678447137 GRN/PRKDC/SERPINB9/CADM1/ADAR/EP300/SFPQ 7 GO:0043113 receptor clustering 1/969 53/18722 0.940435700814378 0.962914767330709 DLG1 1 GO:0050819 negative regulation of coagulation 1/969 53/18722 0.940435700814378 0.962914767330709 ANXA2 1 GO:0071715 icosanoid transport 1/969 53/18722 0.940435700814378 0.962914767330709 ANXA1 1 GO:0097479 synaptic vesicle localization 1/969 53/18722 0.940435700814378 0.962914767330709 KIF5B 1 GO:0090630 activation of GTPase activity 3/969 115/18722 0.941111903443456 0.963418375591676 SYDE2/RABGAP1/EVI5 3 GO:0045921 positive regulation of exocytosis 2/969 86/18722 0.941443064919754 0.963568636363226 SYT7/EXPH5 2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/969 54/18722 0.943527339676174 0.965134836004636 HMOX1 1 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/969 54/18722 0.943527339676174 0.965134836004636 CD46 1 GO:2000300 regulation of synaptic vesicle exocytosis 1/969 54/18722 0.943527339676174 0.965134836004636 CALM1 1 GO:1901606 alpha-amino acid catabolic process 2/969 87/18722 0.943952599864625 0.965380878061161 GLDC/ATP2B4 2 GO:0010324 membrane invagination 4/969 144/18722 0.94427262653102 0.965519222510489 RHOA/ABCA1/SNX18/CDC42 4 GO:0006360 transcription by RNA polymerase I 1/969 55/18722 0.946458666430716 0.967186740470653 BAZ2A 1 GO:0046164 alcohol catabolic process 1/969 55/18722 0.946458666430716 0.967186740470653 TPI1 1 GO:0061098 positive regulation of protein tyrosine kinase activity 1/969 55/18722 0.946458666430716 0.967186740470653 CD24 1 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1/969 56/18722 0.949237985669406 0.969079451671873 CADM1 1 GO:0002711 positive regulation of T cell mediated immunity 1/969 56/18722 0.949237985669406 0.969079451671873 GATA3 1 GO:0002886 regulation of myeloid leukocyte mediated immunity 1/969 56/18722 0.949237985669406 0.969079451671873 HMOX1 1 GO:0050433 regulation of catecholamine secretion 1/969 56/18722 0.949237985669406 0.969079451671873 SYT7 1 GO:0055078 sodium ion homeostasis 1/969 56/18722 0.949237985669406 0.969079451671873 SLC9A1 1 GO:0006400 tRNA modification 2/969 90/18722 0.950881251825465 0.970567465242164 SSB/TPRKB 2 GO:0051289 protein homotetramerization 1/969 57/18722 0.951873172205694 0.971200546260632 ALDOA 1 GO:1902017 regulation of cilium assembly 1/969 57/18722 0.951873172205694 0.971200546260632 ATMIN 1 GO:0051952 regulation of amine transport 2/969 91/18722 0.953003331205976 0.972149976870388 ITGB1/SYT7 2 GO:1903046 meiotic cell cycle process 6/969 202/18722 0.95335417109139 0.972149976870388 ATRX/RAD50/CDC20/PTTG1/CCNE1/AURKA 6 GO:0045834 positive regulation of lipid metabolic process 4/969 149/18722 0.953361774102706 0.972149976870388 ANXA1/SORBS1/CDC42/STOML2 4 GO:0002449 lymphocyte mediated immunity 12/969 350/18722 0.953675327928357 0.972279996830588 CD46/SERPINB9/PRDX1/CTSC/RIF1/CADM1/KIF5B/TFRC/JAG1/TUBB4B/SUPT6H/GATA3 12 GO:0007131 reciprocal meiotic recombination 1/969 58/18722 0.954371693295042 0.972610465904815 RAD50 1 GO:0140527 reciprocal homologous recombination 1/969 58/18722 0.954371693295042 0.972610465904815 RAD50 1 GO:0035249 synaptic transmission, glutamatergic 2/969 92/18722 0.955037623708995 0.972909672807643 EGFR/HOMER1 2 GO:1903351 cellular response to dopamine 2/969 92/18722 0.955037623708995 0.972909672807643 ID1/CAV2 2 GO:0002820 negative regulation of adaptive immune response 1/969 59/18722 0.956740629707232 0.9739467922069 CD46 1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 1/969 59/18722 0.956740629707232 0.9739467922069 CAV1 1 GO:2000351 regulation of endothelial cell apoptotic process 1/969 59/18722 0.956740629707232 0.9739467922069 GATA3 1 GO:0045132 meiotic chromosome segregation 2/969 93/18722 0.956987519705784 0.9739467922069 PTTG1/CCNE1 2 GO:1903350 response to dopamine 2/969 93/18722 0.956987519705784 0.9739467922069 ID1/CAV2 2 GO:1903035 negative regulation of response to wounding 2/969 94/18722 0.958856294236765 0.975601415569708 GJA1/ANXA2 2 GO:0035825 homologous recombination 1/969 60/18722 0.958986695710216 0.975601415569708 RAD50 1 GO:0019748 secondary metabolic process 1/969 61/18722 0.961116258021694 0.97738734470157 AKR1B1 1 GO:0050994 regulation of lipid catabolic process 1/969 61/18722 0.961116258021694 0.97738734470157 IDH1 1 GO:0002718 regulation of cytokine production involved in immune response 2/969 96/18722 0.962363019474084 0.978298417660452 GATA3/HMOX1 2 GO:0032613 interleukin-10 production 1/969 62/18722 0.963135353781673 0.978298417660452 CD46 1 GO:0032653 regulation of interleukin-10 production 1/969 62/18722 0.963135353781673 0.978298417660452 CD46 1 GO:0045576 mast cell activation 1/969 62/18722 0.963135353781673 0.978298417660452 HMOX1 1 GO:0046148 pigment biosynthetic process 1/969 62/18722 0.963135353781673 0.978298417660452 NFE2L1 1 GO:0046173 polyol biosynthetic process 1/969 62/18722 0.963135353781673 0.978298417660452 AKR1B1 1 GO:0090305 nucleic acid phosphodiester bond hydrolysis 8/969 261/18722 0.963369091772292 0.978345680839875 RPS21/N4BP2/RAD50/DICER1/PCF11/AGO2/XPC/NHP2 8 GO:0006639 acylglycerol metabolic process 3/969 128/18722 0.964661385944324 0.979467729346229 CAV1/GPX1/SEL1L 3 GO:0031343 positive regulation of cell killing 1/969 63/18722 0.965049707596548 0.979671672863162 CADM1 1 GO:0002367 cytokine production involved in immune response 2/969 98/18722 0.965581801416642 0.979955750679572 GATA3/HMOX1 2 GO:0140013 meiotic nuclear division 5/969 185/18722 0.965721770343761 0.979955750679572 RAD50/CDC20/PTTG1/CCNE1/AURKA 5 GO:0006638 neutral lipid metabolic process 3/969 129/18722 0.966045788428499 0.979955750679572 CAV1/GPX1/SEL1L 3 GO:0030258 lipid modification 6/969 212/18722 0.966079607252422 0.979955750679572 CROT/PLPP3/SLC27A2/MAPK14/HADHA/ETFA 6 GO:0000045 autophagosome assembly 2/969 99/18722 0.967090257159339 0.980410025977634 RB1CC1/RAB3GAP2 2 GO:0015837 amine transport 2/969 99/18722 0.967090257159339 0.980410025977634 ITGB1/SYT7 2 GO:0031341 regulation of cell killing 2/969 99/18722 0.967090257159339 0.980410025977634 SERPINB9/CADM1 2 GO:0060079 excitatory postsynaptic potential 2/969 100/18722 0.968534979433152 0.981052428565553 APP/PPP1R9A 2 GO:0002720 positive regulation of cytokine production involved in immune response 1/969 65/18722 0.968585621294426 0.981052428565553 GATA3 1 GO:0046503 glycerolipid catabolic process 1/969 65/18722 0.968585621294426 0.981052428565553 PRDX6 1 GO:0072577 endothelial cell apoptotic process 1/969 65/18722 0.968585621294426 0.981052428565553 GATA3 1 GO:0006661 phosphatidylinositol biosynthetic process 3/969 131/18722 0.968662558629593 0.981052428565553 PGAP1/PIK3R1/SMG1 3 GO:0002377 immunoglobulin production 6/969 216/18722 0.970213303383781 0.982246248460696 PRKDC/RIF1/TFRC/YY1/XBP1/SUPT6H 6 GO:0050766 positive regulation of phagocytosis 1/969 66/18722 0.970217209061254 0.982246248460696 LRP1 1 GO:0002443 leukocyte mediated immunity 15/969 440/18722 0.970486928257468 0.982329011635391 CD46/SERPINB9/PRDX1/CTSC/RIF1/CADM1/KIF5B/TFRC/JAG1/TUBB4B/SUPT6H/VAMP2/GATA3/HMOX1/ANXA3 15 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1/969 67/18722 0.971764138972255 0.983240927448016 ANXA1 1 GO:0032890 regulation of organic acid transport 1/969 67/18722 0.971764138972255 0.983240927448016 ITGB1 1 GO:1905037 autophagosome organization 2/969 103/18722 0.972511760486287 0.983806902884502 RB1CC1/RAB3GAP2 2 GO:0009581 detection of external stimulus 3/969 135/18722 0.973334901677665 0.98444904125556 GNAQ/NMT1/NR2F6 3 GO:1901605 alpha-amino acid metabolic process 5/969 195/18722 0.975768164739586 0.986719123244791 GLDC/MTR/ATP2B4/RIMKLB/GCLM 5 GO:0099565 chemical synaptic transmission, postsynaptic 2/969 106/18722 0.976001241725446 0.986763878749697 APP/PPP1R9A 2 GO:0007224 smoothened signaling pathway 3/969 138/18722 0.97639713213947 0.986782326931129 DLG5/GLI3/HES1 3 GO:0009582 detection of abiotic stimulus 3/969 138/18722 0.97639713213947 0.986782326931129 GNAQ/NMT1/NR2F6 3 GO:0009166 nucleotide catabolic process 1/969 73/18722 0.979498383612513 0.989725164879929 PDE4B 1 GO:0009063 cellular amino acid catabolic process 2/969 110/18722 0.979993613024396 0.990034142985791 GLDC/ATP2B4 2 GO:1901568 fatty acid derivative metabolic process 1/969 74/18722 0.980563645357351 0.990418556365968 HPGD 1 GO:0015718 monocarboxylic acid transport 2/969 111/18722 0.98088635709015 0.990553063217995 ANXA1/SLC16A12 2 GO:0003341 cilium movement 4/969 175/18722 0.982220191410553 0.99147419621622 ASH1L/ATP2B4/VPS13A/TMF1 4 GO:0060271 cilium assembly 10/969 337/18722 0.98238848311919 0.99147419621622 DYNLL1/LAMA5/CEP350/GALNT11/PCM1/ATMIN/AHI1/TMEM107/RAB17/ARF4 10 GO:0140029 exocytic process 1/969 76/18722 0.982531146254565 0.99147419621622 VAMP3 1 GO:0001578 microtubule bundle formation 2/969 113/18722 0.982557378913855 0.99147419621622 CLIP1/CAPN6 2 GO:0051321 meiotic cell cycle 7/969 261/18722 0.983585153193975 0.992319693164423 ATRX/DUSP1/RAD50/CDC20/PTTG1/CCNE1/AURKA 7 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1/969 78/18722 0.98429966583425 0.992657285536432 PSAP 1 GO:1901616 organic hydroxy compound catabolic process 1/969 78/18722 0.98429966583425 0.992657285536432 TPI1 1 GO:0006399 tRNA metabolic process 4/969 179/18722 0.984749680151204 0.992732011557096 IARS2/DICER1/SSB/TPRKB 4 GO:0046395 carboxylic acid catabolic process 6/969 236/18722 0.984753683106006 0.992732011557096 CROT/GLDC/SLC27A2/ATP2B4/HADHA/ETFA 6 GO:0007613 memory 2/969 118/18722 0.986137998985924 0.993935811514067 SLC6A4/EIF2AK4 2 GO:0016042 lipid catabolic process 9/969 320/18722 0.986432281547876 0.994040706395912 LRP1/CROT/PRDX6/CYP19A1/SLC27A2/HEXA/IDH1/HADHA/ETFA 9 GO:0016054 organic acid catabolic process 6/969 240/18722 0.986714694842306 0.994133602322323 CROT/GLDC/SLC27A2/ATP2B4/HADHA/ETFA 6 GO:1901292 nucleoside phosphate catabolic process 1/969 83/18722 0.987977417541919 0.995213952211655 PDE4B 1 GO:0046434 organophosphate catabolic process 3/969 155/18722 0.988331240043093 0.995333866890219 PRDX6/PDE4B/IDH1 3 GO:0019730 antimicrobial humoral response 2/969 122/18722 0.988477376417955 0.995333866890219 GAPDH/S100A9 2 GO:0002709 regulation of T cell mediated immunity 1/969 85/18722 0.989195010008806 0.99586459686111 GATA3 1 GO:0046488 phosphatidylinositol metabolic process 3/969 159/18722 0.99014299907579 0.996586421334266 PGAP1/PIK3R1/SMG1 3 GO:0070098 chemokine-mediated signaling pathway 1/969 88/18722 0.990794345090068 0.996586421334266 WNK1 1 GO:1901657 glycosyl compound metabolic process 1/969 88/18722 0.990794345090068 0.996586421334266 AKR1B1 1 GO:0006911 phagocytosis, engulfment 2/969 127/18722 0.990865488950028 0.996586421334266 ABCA1/CDC42 2 GO:0008033 tRNA processing 2/969 127/18722 0.990865488950028 0.996586421334266 SSB/TPRKB 2 GO:0002440 production of molecular mediator of immune response 8/969 308/18722 0.991441428748412 0.996973813092014 PRKDC/RIF1/TFRC/YY1/XBP1/SUPT6H/GATA3/HMOX1 8 GO:0032635 interleukin-6 production 3/969 165/18722 0.99236187915808 0.997383359171692 APP/ISL1/XBP1 3 GO:0032675 regulation of interleukin-6 production 3/969 165/18722 0.99236187915808 0.997383359171692 APP/ISL1/XBP1 3 GO:0050853 B cell receptor signaling pathway 2/969 131/18722 0.992421252907156 0.997383359171692 SLC39A10/FOXP1 2 GO:0044782 cilium organization 10/969 368/18722 0.993021421660707 0.997794645183398 DYNLL1/LAMA5/CEP350/GALNT11/PCM1/ATMIN/AHI1/TMEM107/RAB17/ARF4 10 GO:0002690 positive regulation of leukocyte chemotaxis 1/969 94/18722 0.993318394756784 0.997901178584959 WNK1 1 GO:0006637 acyl-CoA metabolic process 1/969 96/18722 0.993995466271601 0.998197599295809 ACSS1 1 GO:0035383 thioester metabolic process 1/969 96/18722 0.993995466271601 0.998197599295809 ACSS1 1 GO:0044282 small molecule catabolic process 10/969 376/18722 0.994556549288381 0.998569169371965 TPI1/CROT/ENO1/GLDC/LRP5/SLC27A2/ATP2B4/FUT8/HADHA/ETFA 10 GO:0016064 immunoglobulin mediated immune response 4/969 207/18722 0.994954411118289 0.998615344313876 CD46/RIF1/TFRC/SUPT6H 4 GO:0006910 phagocytosis, recognition 1/969 100/18722 0.99515090286601 0.998615344313876 COLEC12 1 GO:0019724 B cell mediated immunity 4/969 210/18722 0.995531665209685 0.998615344313876 CD46/RIF1/TFRC/SUPT6H 4 GO:0006644 phospholipid metabolic process 10/969 383/18722 0.995633175745383 0.998615344313876 PRDX6/GPX4/PLPP3/PGAP1/PIK3R1/SMG1/PISD/IDH1/HADHA/STOML2 10 GO:0046474 glycerophospholipid biosynthetic process 4/969 211/18722 0.995709519404224 0.998615344313876 PGAP1/PIK3R1/SMG1/PISD 4 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1/969 104/18722 0.996084186517479 0.998615344313876 HOMER1 1 GO:0007601 visual perception 4/969 215/18722 0.996355004446948 0.998615344313876 CRYBG3/EFEMP1/EPAS1/TACSTD2 4 GO:0006650 glycerophospholipid metabolic process 7/969 306/18722 0.996455022948993 0.998615344313876 PRDX6/PGAP1/PIK3R1/SMG1/PISD/HADHA/STOML2 7 GO:0007218 neuropeptide signaling pathway 1/969 106/18722 0.996481197670117 0.998615344313876 NPB 1 GO:0046486 glycerolipid metabolic process 10/969 392/18722 0.996723684735325 0.998615344313876 CAV1/PRDX6/GPX1/PGAP1/SEL1L/PIK3R1/SMG1/PISD/HADHA/STOML2 10 GO:0006958 complement activation, classical pathway 1/969 108/18722 0.996837994502955 0.998615344313876 CD46 1 GO:0050953 sensory perception of light stimulus 4/969 219/18722 0.996906162481513 0.998615344313876 CRYBG3/EFEMP1/EPAS1/TACSTD2 4 GO:0008654 phospholipid biosynthetic process 5/969 253/18722 0.997205580504711 0.998615344313876 PGAP1/PIK3R1/SMG1/PISD/IDH1 5 GO:0006520 cellular amino acid metabolic process 6/969 284/18722 0.997277742436686 0.998615344313876 GLDC/MTR/IARS2/ATP2B4/RIMKLB/GCLM 6 GO:0042742 defense response to bacterium 8/969 350/18722 0.997933752472333 0.999080802762531 GRN/S100A9/FOXP1/ANKRD17/COLEC12/RBPJ/TMF1/ANXA3 8 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/969 356/18722 0.998326782237643 0.999187068454545 CD46/ANXA1/CTSC/RIF1/TFRC/JAG1/SUPT6H/GATA3 8 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1/969 121/18722 0.99842228692492 0.999187068454545 CD46 1 GO:0006956 complement activation 1/969 130/18722 0.999025303565597 0.999599126255755 CD46 1 GO:0045017 glycerolipid biosynthetic process 4/969 252/18722 0.999224422774749 0.999606974238292 PGAP1/PIK3R1/SMG1/PISD 4 GO:0006959 humoral immune response 5/969 317/18722 0.999792546980033 0.999983894835914 GAPDH/CD46/S100A9/RBPJ/GATA3 5 GO:0007608 sensory perception of smell 1/969 456/18722 0.999999999978036 0.999999999978036 B3GNT2 1