ID Description GeneRatio BgRatio pvalue p.adjust geneID Count GO:0097493 structural molecule activity conferring elasticity 3/47 11/18367 2.55423630038361e-06 0.000403569335460611 FBN1/FBN2/AHNAK 3 GO:0005041 low-density lipoprotein particle receptor activity 2/47 15/18367 0.000658826469121866 0.0503134217698056 LRP2/LRP1 2 GO:0030228 lipoprotein particle receptor activity 2/47 18/18367 0.000955318134869727 0.0503134217698056 LRP2/LRP1 2 GO:0008237 metallopeptidase activity 4/47 190/18367 0.00139812712887688 0.0552260215906369 ADAMTS1/MBTPS2/ADAMTS6/CPD 4 GO:0004222 metalloendopeptidase activity 3/47 111/18367 0.00287084975031439 0.0907188521099349 ADAMTS1/MBTPS2/ADAMTS6 3 GO:0005201 extracellular matrix structural constituent 3/47 172/18367 0.00967673870682842 0.254321135845766 FBN1/FBN2/LAMB1 3 GO:0038024 cargo receptor activity 2/47 77/18367 0.0166017400058474 0.254321135845766 LRP2/LRP1 2 GO:0070008 serine-type exopeptidase activity 1/47 10/18367 0.0253028355300244 0.254321135845766 CPD 1 GO:0004143 diacylglycerol kinase activity 1/47 11/18367 0.0277983830993486 0.254321135845766 AGK 1 GO:0010485 H4 histone acetyltransferase activity 1/47 11/18367 0.0277983830993486 0.254321135845766 KAT2A 1 GO:0019107 myristoyltransferase activity 1/47 11/18367 0.0277983830993486 0.254321135845766 ZDHHC17 1 GO:1901681 sulfur compound binding 3/47 265/18367 0.0302157780550941 0.254321135845766 FBN1/LRP1/ADAMTS1 3 GO:0045295 gamma-catenin binding 1/47 12/18367 0.0302876768449546 0.254321135845766 DSC3 1 GO:0031994 insulin-like growth factor I binding 1/47 13/18367 0.0327707320990152 0.254321135845766 LRP2 1 GO:0044548 S100 protein binding 1/47 14/18367 0.0352475641569507 0.254321135845766 AHNAK 1 GO:0071837 HMG box domain binding 1/47 14/18367 0.0352475641569507 0.254321135845766 JUN 1 GO:0042813 Wnt-activated receptor activity 1/47 15/18367 0.0377181882775094 0.254321135845766 FZD10 1 GO:0022841 potassium ion leak channel activity 1/47 16/18367 0.0401826196828585 0.254321135845766 KCNK1 1 GO:0035497 cAMP response element binding 1/47 16/18367 0.0401826196828585 0.254321135845766 JUN 1 GO:0003951 NAD+ kinase activity 1/47 17/18367 0.0426408735586639 0.254321135845766 AGK 1 GO:0015095 magnesium ion transmembrane transporter activity 1/47 17/18367 0.0426408735586639 0.254321135845766 ZDHHC17 1 GO:0034185 apolipoprotein binding 1/47 17/18367 0.0426408735586639 0.254321135845766 LRP1 1 GO:0043395 heparan sulfate proteoglycan binding 1/47 17/18367 0.0426408735586639 0.254321135845766 LRP1 1 GO:0004550 nucleoside diphosphate kinase activity 1/47 18/18367 0.0450929650541809 0.254321135845766 AK9 1 GO:0008569 minus-end-directed microtubule motor activity 1/47 18/18367 0.0450929650541809 0.254321135845766 DYNC1H1 1 GO:0046527 glucosyltransferase activity 1/47 18/18367 0.0450929650541809 0.254321135845766 ALG10B 1 GO:0055102 lipase inhibitor activity 1/47 18/18367 0.0450929650541809 0.254321135845766 FAF2 1 GO:0022840 leak channel activity 1/47 19/18367 0.0475389092823377 0.254321135845766 KCNK1 1 GO:0022842 narrow pore channel activity 1/47 19/18367 0.0475389092823377 0.254321135845766 KCNK1 1 GO:0050145 nucleoside monophosphate kinase activity 1/47 20/18367 0.0499787213198206 0.254321135845766 AK9 1 GO:0019838 growth factor binding 2/47 141/18367 0.0505330167390407 0.254321135845766 LRP2/LIFR 2 GO:0005178 integrin binding 2/47 144/18367 0.0524623253806153 0.254321135845766 FBN1/LAMB1 2 GO:0070412 R-SMAD binding 1/47 23/18367 0.0572615145132315 0.254321135845766 JUN 1 GO:0000030 mannosyltransferase activity 1/47 24/18367 0.0596769478330024 0.254321135845766 TMTC2 1 GO:0005242 inward rectifier potassium channel activity 1/47 25/18367 0.0620863238048636 0.254321135845766 KCNK1 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/47 26/18367 0.0644896572898256 0.254321135845766 ZDHHC17 1 GO:0019707 protein-cysteine S-acyltransferase activity 1/47 26/18367 0.0644896572898256 0.254321135845766 ZDHHC17 1 GO:0051959 dynein light intermediate chain binding 1/47 27/18367 0.0668869631132474 0.254321135845766 DYNC1H1 1 GO:0008201 heparin binding 2/47 166/18367 0.0673797573590648 0.254321135845766 FBN1/ADAMTS1 2 GO:0070325 lipoprotein particle receptor binding 1/47 28/18367 0.0692782560649202 0.254321135845766 LRP1 1 GO:0004181 metallocarboxypeptidase activity 1/47 29/18367 0.0716635508991499 0.254321135845766 CPD 1 GO:0005520 insulin-like growth factor binding 1/47 29/18367 0.0716635508991499 0.254321135845766 LRP2 1 GO:0032452 histone demethylase activity 1/47 29/18367 0.0716635508991499 0.254321135845766 KDM5B 1 GO:0140457 protein demethylase activity 1/47 29/18367 0.0716635508991499 0.254321135845766 KDM5B 1 GO:0016417 S-acyltransferase activity 1/47 30/18367 0.0740428623348434 0.254321135845766 ZDHHC17 1 GO:0017147 Wnt-protein binding 1/47 30/18367 0.0740428623348434 0.254321135845766 FZD10 1 GO:0140318 protein transporter activity 1/47 31/18367 0.0764162050555863 0.256888519123035 LRP2 1 GO:0008175 tRNA methyltransferase activity 1/47 32/18367 0.0787835937097303 0.259329329294529 NSUN6 1 GO:0045505 dynein intermediate chain binding 1/47 34/18367 0.0835005672359467 0.269246727005706 DYNC1H1 1 GO:0043394 proteoglycan binding 1/47 36/18367 0.08819389939873 0.273454402123888 LRP1 1 GO:0016758 hexosyltransferase activity 2/47 197/18367 0.0904337571082852 0.273454402123888 ALG10B/TMTC2 2 GO:0016409 palmitoyltransferase activity 1/47 37/18367 0.0905317362176845 0.273454402123888 ZDHHC17 1 GO:0004402 histone acetyltransferase activity 1/47 39/18367 0.0951898235241382 0.273454402123888 KAT2A 1 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/47 39/18367 0.0951898235241382 0.273454402123888 AK9 1 GO:0032451 demethylase activity 1/47 39/18367 0.0951898235241382 0.273454402123888 KDM5B 1 GO:0004175 endopeptidase activity 3/47 430/18367 0.0972453761064263 0.274370882585989 ADAMTS1/MBTPS2/ADAMTS6 3 GO:0061733 peptide-lysine-N-acetyltransferase activity 1/47 41/18367 0.0998245582425433 0.276706670216173 KAT2A 1 GO:0019205 nucleobase-containing compound kinase activity 1/47 42/18367 0.102133204197067 0.278224935571321 AK9 1 GO:0004180 carboxypeptidase activity 1/47 43/18367 0.104436054914816 0.279676214856625 CPD 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/47 222/18367 0.110469828857268 0.287152247816536 KAT2A/ZDHHC17 2 GO:0005272 sodium channel activity 1/47 46/18367 0.111309977795784 0.287152247816536 KCNK1 1 GO:0005044 scavenger receptor activity 1/47 47/18367 0.113589789544247 0.287152247816536 LRP1 1 GO:0015026 coreceptor activity 1/47 48/18367 0.115863876874565 0.287152247816536 LRP1 1 GO:0005539 glycosaminoglycan binding 2/47 230/18367 0.117112693443708 0.287152247816536 FBN1/ADAMTS1 2 GO:0034212 peptide N-acetyltransferase activity 1/47 49/18367 0.118132253848575 0.287152247816536 KAT2A 1 GO:0042393 histone binding 2/47 244/18367 0.128975155406546 0.30063908473811 BPTF/KDM5B 2 GO:0003712 transcription coregulator activity 3/47 489/18367 0.129309336767362 0.30063908473811 MAML2/KAT2A/KDM5B 3 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/47 54/18367 0.129388973178427 0.30063908473811 KDM5B 1 GO:0016746 acyltransferase activity 2/47 250/18367 0.134144456639678 0.307171364479262 KAT2A/ZDHHC17 2 GO:0003713 transcription coactivator activity 2/47 262/18367 0.144622703540984 0.326434102278222 MAML2/KAT2A 2 GO:1990841 promoter-specific chromatin binding 1/47 62/18367 0.147107849094557 0.327366762773803 ZNF609 1 GO:0016757 glycosyltransferase activity 2/47 270/18367 0.151703531127397 0.329287739651111 ALG10B/TMTC2 2 GO:0008173 RNA methyltransferase activity 1/47 65/18367 0.153661021433782 0.329287739651111 NSUN6 1 GO:0008080 N-acetyltransferase activity 1/47 68/18367 0.160164905899671 0.329287739651111 KAT2A 1 GO:0003777 microtubule motor activity 1/47 69/18367 0.162321977292791 0.329287739651111 DYNC1H1 1 GO:0004857 enzyme inhibitor activity 1/47 70/18367 0.164473625946592 0.329287739651111 FAF2 1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/47 71/18367 0.166619865197863 0.329287739651111 FAAH2 1 GO:0000049 tRNA binding 1/47 72/18367 0.168760708351323 0.329287739651111 NSUN6 1 GO:0008235 metalloexopeptidase activity 1/47 72/18367 0.168760708351323 0.329287739651111 CPD 1 GO:0030276 clathrin binding 1/47 72/18367 0.168760708351323 0.329287739651111 LRP1 1 GO:0035064 methylated histone binding 1/47 73/18367 0.17089616867969 0.329287739651111 BPTF 1 GO:0140034 methylation-dependent protein binding 1/47 73/18367 0.17089616867969 0.329287739651111 BPTF 1 GO:0031625 ubiquitin protein ligase binding 2/47 297/18367 0.176082485633164 0.335193165422168 FAF2/JUN 2 GO:0046332 SMAD binding 1/47 79/18367 0.183596630582391 0.345336519428783 JUN 1 GO:0044389 ubiquitin-like protein ligase binding 2/47 316/18367 0.193601993419696 0.356482410982011 FAF2/JUN 2 GO:0001540 amyloid-beta binding 1/47 84/18367 0.194034730028183 0.356482410982011 LRP1 1 GO:0042562 hormone binding 1/47 86/18367 0.19817329717893 0.35990093050886 LRP2 1 GO:0005249 voltage-gated potassium channel activity 1/47 90/18367 0.206388129777706 0.36542205155691 KCNK1 1 GO:0016407 acetyltransferase activity 1/47 91/18367 0.208428932858105 0.36542205155691 KAT2A 1 GO:0043130 ubiquitin binding 1/47 92/18367 0.210464599314423 0.36542205155691 FAF2 1 GO:0051213 dioxygenase activity 1/47 92/18367 0.210464599314423 0.36542205155691 KDM5B 1 GO:0016410 N-acyltransferase activity 1/47 94/18367 0.214520572917651 0.368415766532487 KAT2A 1 GO:0004896 cytokine receptor activity 1/47 97/18367 0.220566323861666 0.374725582474659 LIFR 1 GO:0008238 exopeptidase activity 1/47 103/18367 0.232521508881634 0.390834025567002 CPD 1 GO:0051087 chaperone binding 1/47 107/18367 0.240391730088082 0.396089952397033 LRP2 1 GO:0000149 SNARE binding 1/47 110/18367 0.246242505449903 0.396089952397033 NBAS 1 GO:0047485 protein N-terminus binding 1/47 110/18367 0.246242505449903 0.396089952397033 TDRD7 1 GO:0008094 ATP-dependent activity, acting on DNA 1/47 111/18367 0.248182944856369 0.396089952397033 BPTF 1 GO:0032182 ubiquitin-like protein binding 1/47 111/18367 0.248182944856369 0.396089952397033 FAF2 1 GO:0099094 ligand-gated cation channel activity 1/47 113/18367 0.252049167632672 0.397307386756905 KCNK1 1 GO:0003774 cytoskeletal motor activity 1/47 114/18367 0.253974975078781 0.397307386756905 DYNC1H1 1 GO:0005267 potassium channel activity 1/47 121/18367 0.267320403084233 0.412959411497738 KCNK1 1 GO:0005179 hormone activity 1/47 122/18367 0.269207717621943 0.412959411497738 FBN1 1 GO:0140101 catalytic activity, acting on a tRNA 1/47 124/18367 0.272968083322858 0.413570504315838 NSUN6 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/47 125/18367 0.274841157931411 0.413570504315838 FAAH2 1 GO:0042826 histone deacetylase binding 1/47 127/18367 0.278573149066162 0.414095981693612 KAT2A 1 GO:0140678 molecular function inhibitor activity 1/47 128/18367 0.280432088868459 0.414095981693612 FAF2 1 GO:0017124 SH3 domain binding 1/47 130/18367 0.284135914922727 0.415680319979545 LRP2 1 GO:0002020 protease binding 1/47 135/18367 0.293314038903784 0.425170808686219 LRP1 1 GO:0019955 cytokine binding 1/47 139/18367 0.300573525282762 0.425288335128261 LIFR 1 GO:0046873 metal ion transmembrane transporter activity 2/47 430/18367 0.301554842129085 0.425288335128261 KCNK1/ZDHHC17 2 GO:0015276 ligand-gated ion channel activity 1/47 143/18367 0.307760008728656 0.425288335128261 KCNK1 1 GO:0022834 ligand-gated channel activity 1/47 143/18367 0.307760008728656 0.425288335128261 KCNK1 1 GO:0022843 voltage-gated cation channel activity 1/47 143/18367 0.307760008728656 0.425288335128261 KCNK1 1 GO:0140375 immune receptor activity 1/47 144/18367 0.309545307213607 0.425288335128261 LIFR 1 GO:0019903 protein phosphatase binding 1/47 150/18367 0.320162848155024 0.429765244777177 KAT2A 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 2/47 450/18367 0.320516920574928 0.429765244777177 FOXJ2/JUN 2 GO:0015081 sodium ion transmembrane transporter activity 1/47 152/18367 0.323666389052574 0.429765244777177 KCNK1 1 GO:0001216 DNA-binding transcription activator activity 2/47 456/18367 0.326185924349427 0.429765244777177 FOXJ2/JUN 2 GO:0015079 potassium ion transmembrane transporter activity 1/47 155/18367 0.328888590276833 0.429765244777177 KCNK1 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/47 156/18367 0.330620538237352 0.429765244777177 NSUN6 1 GO:0005096 GTPase activator activity 2/47 462/18367 0.331844049764655 0.429765244777177 ITSN2/JUN 2 GO:0140030 modification-dependent protein binding 1/47 160/18367 0.337504689990024 0.433542609905884 BPTF 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/47 170/18367 0.35441333845438 0.446680708776756 KDM5B 1 GO:0030695 GTPase regulator activity 2/47 488/18367 0.356213729783995 0.446680708776756 ITSN2/JUN 2 GO:0060589 nucleoside-triphosphatase regulator activity 2/47 488/18367 0.356213729783995 0.446680708776756 ITSN2/JUN 2 GO:0003714 transcription corepressor activity 1/47 187/18367 0.382193715768513 0.475485095208072 KDM5B 1 GO:0008236 serine-type peptidase activity 1/47 191/18367 0.388558262531156 0.479626605311895 CPD 1 GO:0017171 serine hydrolase activity 1/47 195/18367 0.394858623650737 0.481807338204083 CPD 1 GO:0019902 phosphatase binding 1/47 196/18367 0.396423759281841 0.481807338204083 KAT2A 1 GO:0005244 voltage-gated ion channel activity 1/47 201/18367 0.40419020107587 0.483803422499905 KCNK1 1 GO:0022832 voltage-gated channel activity 1/47 201/18367 0.40419020107587 0.483803422499905 KCNK1 1 GO:0019887 protein kinase regulator activity 1/47 204/18367 0.408803028187887 0.485645702659295 ANKRD54 1 GO:0008168 methyltransferase activity 1/47 214/18367 0.423928089935128 0.499855509027987 NSUN6 1 GO:0000287 magnesium ion binding 1/47 221/18367 0.434289612534398 0.507593283399778 RPS6KA4 1 GO:0005085 guanyl-nucleotide exchange factor activity 1/47 223/18367 0.437216393715057 0.507593283399778 ITSN2 1 GO:0016741 transferase activity, transferring one-carbon groups 1/47 225/18367 0.440128353327656 0.507593283399778 NSUN6 1 GO:0140097 catalytic activity, acting on DNA 1/47 229/18367 0.445908101231167 0.510532463728438 BPTF 1 GO:0019207 kinase regulator activity 1/47 233/18367 0.451629439462112 0.513362959964127 ANKRD54 1 GO:0005126 cytokine receptor binding 1/47 271/18367 0.503177158541237 0.567871364639396 LIFR 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 1/47 299/18367 0.538094096177436 0.602970689333581 JUN 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/47 310/18367 0.551144122382867 0.612819174836717 JUN 1 GO:0001217 DNA-binding transcription repressor activity 1/47 313/18367 0.554640139250953 0.612819174836717 JUN 1 GO:0042277 peptide binding 1/47 321/18367 0.563833078932297 0.618650183828492 LRP1 1 GO:0045296 cadherin binding 1/47 332/18367 0.57617074466268 0.627104004764423 AHNAK 1 GO:0005261 cation channel activity 1/47 335/18367 0.579475852503834 0.627104004764423 KCNK1 1 GO:0022836 gated channel activity 1/47 340/18367 0.584928392641652 0.62869854447198 KCNK1 1 GO:0106310 protein serine kinase activity 1/47 360/18367 0.606054969645179 0.64700462975634 RPS6KA4 1 GO:0060090 molecular adaptor activity 1/47 369/18367 0.615215062462745 0.652375703819555 ITSN2 1 GO:0004674 protein serine/threonine kinase activity 1/47 386/18367 0.631952174559036 0.661247970730647 RPS6KA4 1 GO:0140098 catalytic activity, acting on RNA 1/47 386/18367 0.631952174559036 0.661247970730647 NSUN6 1 GO:0140297 DNA-binding transcription factor binding 1/47 394/18367 0.639579837308406 0.664826409833738 JUN 1 GO:0033218 amide binding 1/47 400/18367 0.645198837175514 0.666283766494975 LRP1 1 GO:0005216 ion channel activity 1/47 432/18367 0.673749223893468 0.691249203734857 KCNK1 1 GO:0015267 channel activity 1/47 480/18367 0.712406472226812 0.722226662975784 KCNK1 1 GO:0022803 passive transmembrane transporter activity 1/47 481/18367 0.713162154890498 0.722226662975784 KCNK1 1 GO:0048018 receptor ligand activity 1/47 487/18367 0.717655608146823 0.722226662975784 FBN1 1 GO:0030546 signaling receptor activator activity 1/47 495/18367 0.723539853516103 0.723539853516103 FBN1 1