ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0019838	growth factor binding	15/407	141/18367	5.68613565034748e-07	0.00037244188509776	LRP2/ITGB4/LTBP1/RHBDF1/COL4A1/ACVR2A/ITGA6/NRP1/FGFR2/ERBB3/ITGAV/IL6ST/EGFR/SHC1/GPC1	15
GO:0019199	transmembrane receptor protein kinase activity	13/407	143/18367	1.81592368221909e-05	0.00594715005926753	MET/LTBP1/EPHB3/EPHA1/EPHB4/ACVR2A/PDGFRL/NRP1/ABL1/FGFR2/ERBB3/PTK2/EGFR	13
GO:0004714	transmembrane receptor protein tyrosine kinase activity	11/407	124/18367	9.93409815205828e-05	0.0216894476319939	MET/EPHB3/EPHA1/EPHB4/PDGFRL/NRP1/ABL1/FGFR2/ERBB3/PTK2/EGFR	11
GO:0031994	insulin-like growth factor I binding	4/407	13/18367	0.00014494903248599	0.0237354040695809	LRP2/ITGB4/ITGA6/ITGAV	4
GO:0004713	protein tyrosine kinase activity	11/407	136/18367	0.000225823669285174	0.0295829006763578	MET/EPHB3/EPHA1/EPHB4/PDGFRL/NRP1/ABL1/FGFR2/ERBB3/PTK2/EGFR	11
GO:0005178	integrin binding	10/407	144/18367	0.00140857260679185	0.146075069858595	ITGB4/DST/JAM3/MMP14/FERMT2/ITGB5/LAMA5/ITGAV/PTK2/EGFR	10
GO:0017128	phospholipid scramblase activity	3/407	11/18367	0.00156110761680941	0.146075069858595	PLSCR4/XKR8/ANO6	3
GO:0004177	aminopeptidase activity	5/407	40/18367	0.00181175460251023	0.148337408080525	MMP15/CTSV/BLMH/MMP14/RNPEP	5
GO:0017154	semaphorin receptor activity	3/407	12/18367	0.00204743272701272	0.149007604021481	MET/NRP1/PLXNB1	3
GO:0008514	organic anion transmembrane transporter activity	11/407	185/18367	0.00285434965994527	0.158995347066321	SLC7A11/SLC1A3/GJA1/SLC38A9/SLC22A11/SLC27A6/SLC26A2/SLC25A11/SLC16A1/SLC25A4/SLC2A1	11
GO:0008276	protein methyltransferase activity	7/407	88/18367	0.00339165171205901	0.158995347066321	METTL21C/DNMT3A/ICMT/SUV39H1/EZH2/SETD4/WDR5	7
GO:0005520	insulin-like growth factor binding	4/407	29/18367	0.00363909988434723	0.158995347066321	LRP2/ITGB4/ITGA6/ITGAV	4
GO:0004467	long-chain fatty acid-CoA ligase activity	3/407	15/18367	0.00403052102679978	0.158995347066321	SLC27A2/SLC27A6/ACSF2	3
GO:0032794	GTPase activating protein binding	3/407	15/18367	0.00403052102679978	0.158995347066321	CDH1/PLXNB1/ARL3	3
GO:0042813	Wnt-activated receptor activity	3/407	15/18367	0.00403052102679978	0.158995347066321	FZD5/LRP5/FZD3	3
GO:0015026	coreceptor activity	5/407	48/18367	0.00408114968139825	0.158995347066321	LRP5/ACVR2A/LRP1/NRP1/ITGAV	5
GO:0017147	Wnt-protein binding	4/407	30/18367	0.00412659679408772	0.158995347066321	FZD5/LRP5/WLS/FZD3	4
GO:0008509	anion transmembrane transporter activity	15/407	314/18367	0.0045335957365269	0.164972511523618	GABRE/SLC7A11/ANO2/SLC1A3/GJA1/CLDN4/SLC38A9/SLC22A11/SLC27A6/SLC26A2/SLC25A11/SLC16A1/SLC25A4/SLC2A1/ANO6	15
GO:1901682	sulfur compound transmembrane transporter activity	5/407	52/18367	0.00576473424070806	0.166570478292848	SLC7A11/SLC19A3/GJA1/SLC26A2/SLC25A11	5
GO:0005005	transmembrane-ephrin receptor activity	3/407	17/18367	0.00582918881087057	0.166570478292848	EPHB3/EPHA1/EPHB4	3
GO:0005324	long-chain fatty acid transporter activity	3/407	17/18367	0.00582918881087057	0.166570478292848	SLC27A2/SLC27A6/SLC2A1	3
GO:0070064	proline-rich region binding	3/407	17/18367	0.00582918881087057	0.166570478292848	YAP1/ABL1/WBP4	3
GO:0140323	solute:anion antiporter activity	4/407	33/18367	0.00584903969577941	0.166570478292848	SLC7A11/SLC26A2/SLC25A11/SLC25A4	4
GO:0001618	virus receptor activity	6/407	76/18367	0.0067691442662487	0.18157766867833	DAG1/SCARB2/TFRC/ITGB5/ITGAV/EGFR	6
GO:0038024	cargo receptor activity	6/407	77/18367	0.00720766318417797	0.18157766867833	LRP2/LRP1/SCARB2/TFRC/SCARA3/ACKR2	6
GO:0140272	exogenous protein binding	6/407	77/18367	0.00720766318417797	0.18157766867833	DAG1/SCARB2/TFRC/ITGB5/ITGAV/EGFR	6
GO:0050840	extracellular matrix binding	5/407	56/18367	0.007886349537082	0.182661049213577	DAG1/ITGA6/ITGAV/ADGRG1/GPC1	5
GO:0005003	ephrin receptor activity	3/407	19/18367	0.00803906215334067	0.182661049213577	EPHB3/EPHA1/EPHB4	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	9/407	156/18367	0.00808728309495228	0.182661049213577	METTL21C/DNMT3A/MRM1/ICMT/SUV39H1/EZH2/SETD4/WDR5/NSUN4	9
GO:0031418	L-ascorbic acid binding	3/407	20/18367	0.00930443719802989	0.200511902273915	P3H2/PLOD1/P3H1	3
GO:0140303	intramembrane lipid transporter activity	4/407	38/18367	0.00967669555825014	0.200511902273915	TMEM30B/PLSCR4/XKR8/ANO6	4
GO:0016279	protein-lysine N-methyltransferase activity	5/407	59/18367	0.00979600133246609	0.200511902273915	METTL21C/SUV39H1/EZH2/SETD4/WDR5	5
GO:0043177	organic acid binding	8/407	135/18367	0.0104865315377564	0.202227313909761	P3H2/PLOD1/SLC1A3/PPARG/NR2F2/GLDC/P3H1/SHMT1	8
GO:0016278	lysine N-methyltransferase activity	5/407	60/18367	0.0104972956838654	0.202227313909761	METTL21C/SUV39H1/EZH2/SETD4/WDR5	5
GO:0016741	transferase activity, transferring one-carbon groups	11/407	225/18367	0.0119377036506588	0.221348778598332	METTL21C/NSUN7/DNMT3A/MRM1/ICMT/SUV39H1/SHMT1/EZH2/SETD4/WDR5/NSUN4	11
GO:0015645	fatty acid ligase activity	3/407	22/18367	0.0121657343962442	0.221348778598332	SLC27A2/SLC27A6/ACSF2	3
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/407	41/18367	0.0126065964489342	0.22317082902843	COL21A1/COL14A1/COL4A1/COL4A2	4
GO:0017134	fibroblast growth factor binding	3/407	23/18367	0.0137646425754017	0.231175407356105	FGFR2/ITGAV/GPC1	3
GO:0030215	semaphorin receptor binding	3/407	23/18367	0.0137646425754017	0.231175407356105	SEMA4G/SEMA6A/PLXNB1	3
GO:0018024	histone-lysine N-methyltransferase activity	4/407	43/18367	0.0148430072526735	0.243054243762528	SUV39H1/EZH2/SETD4/WDR5	4
GO:0000030	mannosyltransferase activity	3/407	24/18367	0.0154772604104378	0.247258672410652	PIGV/TMTC2/TMTC3	3
GO:0035035	histone acetyltransferase binding	3/407	25/18367	0.0173044217061144	0.262033779516354	GLI3/PCNA/ECD	3
GO:0008017	microtubule binding	12/407	271/18367	0.018163706975931	0.262033779516354	DST/MAP10/CENPE/LZTS1/GAS2L3/KIF11/RACGAP1/JAKMIP2/SAXO2/ARL3/CLIP1/CEP44	12
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/407	10/18367	0.0195954181681061	0.262033779516354	SLC27A2/SLC27A6	2
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	2/407	10/18367	0.0195954181681061	0.262033779516354	SYNJ2/INPP4A	2
GO:0003697	single-stranded DNA binding	7/407	123/18367	0.0197649017435127	0.262033779516354	MCM10/SMARCA1/TSN/BLM/SMC2/MCM5/SPRTN	7
GO:0005044	scavenger receptor activity	4/407	47/18367	0.0200293370485271	0.262033779516354	LRP1/SCARB2/SCARA3/ACKR2	4
GO:0016405	CoA-ligase activity	3/407	27/18367	0.0213045321617698	0.262033779516354	SLC27A2/SLC27A6/ACSF2	3
GO:0070006	metalloaminopeptidase activity	3/407	27/18367	0.0213045321617698	0.262033779516354	MMP15/MMP14/RNPEP	3
GO:0008168	methyltransferase activity	10/407	214/18367	0.0213413376538689	0.262033779516354	METTL21C/NSUN7/DNMT3A/MRM1/ICMT/SUV39H1/EZH2/SETD4/WDR5/NSUN4	10
GO:0001968	fibronectin binding	3/407	28/18367	0.0234780104853497	0.262033779516354	CCDC80/EPHA1/ITGAV	3
GO:0003785	actin monomer binding	3/407	28/18367	0.0234780104853497	0.262033779516354	COBL/ABL1/LIMA1	3
GO:0015101	organic cation transmembrane transporter activity	3/407	28/18367	0.0234780104853497	0.262033779516354	SLC44A5/SLC19A3/SLC44A2	3
GO:0043236	laminin binding	3/407	28/18367	0.0234780104853497	0.262033779516354	DAG1/ITGA6/GPC1	3
GO:0002162	dystroglycan binding	2/407	11/18367	0.0236030427350609	0.262033779516354	DAG1/DMD	2
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/407	11/18367	0.0236030427350609	0.262033779516354	PCYOX1/ERO1B	2
GO:0035251	UDP-glucosyltransferase activity	2/407	11/18367	0.0236030427350609	0.262033779516354	UGGT2/GYG1	2
GO:0047676	arachidonate-CoA ligase activity	2/407	11/18367	0.0236030427350609	0.262033779516354	SLC27A2/SLC27A6	2
GO:0097493	structural molecule activity conferring elasticity	2/407	11/18367	0.0236030427350609	0.262033779516354	FBN2/LAMC1	2
GO:0015301	anion:anion antiporter activity	3/407	29/18367	0.0257671155546962	0.281288890807988	SLC26A2/SLC25A11/SLC25A4	3
GO:0008238	exopeptidase activity	6/407	103/18367	0.0270585708672668	0.281288890807988	MMP15/CTSV/TFRC/BLMH/MMP14/RNPEP	6
GO:0017166	vinculin binding	2/407	12/18367	0.0279141647366705	0.281288890807988	DAG1/DMD	2
GO:0031543	peptidyl-proline dioxygenase activity	2/407	12/18367	0.0279141647366705	0.281288890807988	P3H2/P3H1	2
GO:0045295	gamma-catenin binding	2/407	12/18367	0.0279141647366705	0.281288890807988	DSC3/CDH1	2
GO:0097677	STAT family protein binding	2/407	12/18367	0.0279141647366705	0.281288890807988	PPARG/CEBPA	2
GO:0046943	carboxylic acid transmembrane transporter activity	8/407	163/18367	0.029055628635206	0.288355102364544	SLC7A11/SLC1A3/SLC27A2/SLC38A9/SLC27A6/SLC26A2/SLC25A11/SLC16A1	8
GO:0005342	organic acid transmembrane transporter activity	8/407	164/18367	0.0299806902432252	0.2917301366979	SLC7A11/SLC1A3/SLC27A2/SLC38A9/SLC27A6/SLC26A2/SLC25A11/SLC16A1	8
GO:0016878	acid-thiol ligase activity	3/407	31/18367	0.0306911099935555	0.2917301366979	SLC27A2/SLC27A6/ACSF2	3
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4/407	54/18367	0.0315110234277327	0.2917301366979	P3H2/PLOD1/KDM5B/P3H1	4
GO:0016758	hexosyltransferase activity	9/407	197/18367	0.0318738900496318	0.2917301366979	UGGT2/CHPF/GCNT2/PIGV/TMTC2/TMTC3/GALNT11/EXTL2/GYG1	9
GO:0019104	DNA N-glycosylase activity	2/407	13/18367	0.0325134350823614	0.2917301366979	PCNA/TDG	2
GO:0042301	phosphate ion binding	2/407	13/18367	0.0325134350823614	0.2917301366979	GNG12/CHST14	2
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	2/407	13/18367	0.0325134350823614	0.2917301366979	SYNJ2/INPP4A	2
GO:0042054	histone methyltransferase activity	4/407	56/18367	0.035372263875574	0.302440327632431	SUV39H1/EZH2/SETD4/WDR5	4
GO:0003779	actin binding	16/407	440/18367	0.0369390361107943	0.302440327632431	DST/TNS4/MYO9A/COBL/GAS2L3/DAG1/WASF1/ABL1/FERMT2/EPB41L3/CYFIP1/DMD/MYO1C/PTK2/EGFR/LIMA1	16
GO:0032182	ubiquitin-like protein binding	6/407	111/18367	0.0370826026908708	0.302440327632431	HGS/DCUN1D3/USP5/TDG/SPRTN/RNF19B	6
GO:0005313	L-glutamate transmembrane transporter activity	2/407	14/18367	0.0373860329931369	0.302440327632431	SLC7A11/SLC1A3	2
GO:0019992	diacylglycerol binding	2/407	14/18367	0.0373860329931369	0.302440327632431	UNC13B/RAPGEF2	2
GO:0030983	mismatched DNA binding	2/407	14/18367	0.0373860329931369	0.302440327632431	PCNA/TDG	2
GO:0140666	annealing activity	2/407	14/18367	0.0373860329931369	0.302440327632431	SMARCA1/BLM	2
GO:0005548	phospholipid transporter activity	4/407	57/18367	0.0374010176156136	0.302440327632431	TMEM30B/PLSCR4/XKR8/ANO6	4
GO:0005201	extracellular matrix structural constituent	8/407	172/18367	0.0381174960676013	0.303584928605012	LTBP1/COL21A1/COL14A1/COL4A1/COL4A2/FBN2/LAMC1/LAMA5	8
GO:0030165	PDZ domain binding	5/407	84/18367	0.0387797155994681	0.303584928605012	ACVR2A/GJA1/FZD3/GNG12/RAPGEF2	5
GO:0008376	acetylgalactosaminyltransferase activity	3/407	34/18367	0.0389330290119404	0.303584928605012	CHPF/GALNT11/EXTL2	3
GO:0015631	tubulin binding	14/407	375/18367	0.0407354610477084	0.313902670426459	DST/MAP10/CENPE/LZTS1/GAS2L3/GJA1/DAG1/KIF11/RACGAP1/JAKMIP2/SAXO2/ARL3/CLIP1/CEP44	14
GO:0005041	low-density lipoprotein particle receptor activity	2/407	15/18367	0.0425176502187272	0.317770880261381	LRP2/LRP1	2
GO:0043138	3'-5' DNA helicase activity	2/407	15/18367	0.0425176502187272	0.317770880261381	BLM/MCM5	2
GO:0031406	carboxylic acid binding	8/407	176/18367	0.0426928816229031	0.317770880261381	P3H2/PLOD1/SLC1A3/PPARG/NR2F2/GLDC/P3H1/SHMT1	8
GO:0043621	protein self-association	4/407	61/18367	0.0461720067194182	0.339805217991224	PPARG/ACVR2A/TDG/SLC2A1	4
GO:0019842	vitamin binding	7/407	148/18367	0.046945482390912	0.340987843242455	P3H2/PLOD1/GLDC/P3H1/SHMT1/MMAB/GGCX	7
GO:0003688	DNA replication origin binding	2/407	16/18367	0.0478944756920701	0.340987843242455	MCM10/MCM5	2
GO:0015172	acidic amino acid transmembrane transporter activity	2/407	16/18367	0.0478944756920701	0.340987843242455	SLC7A11/SLC1A3	2
GO:0015103	inorganic anion transmembrane transporter activity	7/407	152/18367	0.0527954033433473	0.361284363909938	GABRE/ANO2/CLDN4/SLC22A11/SLC26A2/SLC25A11/ANO6	7
GO:0000400	four-way junction DNA binding	2/407	17/18367	0.0535031806095634	0.361284363909938	ABL1/BLM	2
GO:0008574	plus-end-directed microtubule motor activity	2/407	17/18367	0.0535031806095634	0.361284363909938	CENPE/KIF11	2
GO:0015116	sulfate transmembrane transporter activity	2/407	17/18367	0.0535031806095634	0.361284363909938	SLC26A2/SLC25A11	2
GO:0042800	histone methyltransferase activity (H3-K4 specific)	2/407	17/18367	0.0535031806095634	0.361284363909938	SETD4/WDR5	2
GO:0005319	lipid transporter activity	7/407	154/18367	0.055884457688556	0.373513467204124	SLC27A2/TMEM30B/SLC27A6/PLSCR4/XKR8/SLC2A1/ANO6	7
GO:0042169	SH2 domain binding	3/407	40/18367	0.0583994819526326	0.377298466712785	DAG1/ABL1/PTK2	3
GO:0005229	intracellular calcium activated chloride channel activity	2/407	18/18367	0.0593309039258272	0.377298466712785	ANO2/ANO6	2
GO:0030228	lipoprotein particle receptor activity	2/407	18/18367	0.0593309039258272	0.377298466712785	LRP2/LRP1	2
GO:0046527	glucosyltransferase activity	2/407	18/18367	0.0593309039258272	0.377298466712785	UGGT2/GYG1	2
GO:0061778	intracellular chloride channel activity	2/407	18/18367	0.0593309039258272	0.377298466712785	ANO2/ANO6	2
GO:0008022	protein C-terminus binding	8/407	189/18367	0.0600118407365641	0.377959189254322	DST/SYT1/HIC2/PPARG/YAP1/ABL1/PCNA/MYO1C	8
GO:0008234	cysteine-type peptidase activity	8/407	190/18367	0.0615030866083893	0.380513709004107	CTSV/USP43/USP40/BLMH/OTUD3/USP5/CAPN15/USP27X	8
GO:0016877	ligase activity, forming carbon-sulfur bonds	3/407	41/18367	0.0620147097555562	0.380513709004107	SLC27A2/SLC27A6/ACSF2	3
GO:0016853	isomerase activity	7/407	158/18367	0.0623937689045833	0.380513709004107	PBLD/PMM1/ENOSF1/GLCE/PPIL1/ERO1B/FKBP4	7
GO:0031267	small GTPase binding	10/407	259/18367	0.063587555848608	0.380513709004107	UNC13B/WASF1/CDC42EP4/HACE1/MICALL1/RAB11FIP3/YIPF1/CYFIP1/MYO1C/STK19	10
GO:0003684	damaged DNA binding	4/407	68/18367	0.0640310051565885	0.380513709004107	POLI/PCNA/BLM/TDG	4
GO:0016782	transferase activity, transferring sulphur-containing groups	4/407	68/18367	0.0640310051565885	0.380513709004107	MPST/HS6ST2/CHST11/CHST14	4
GO:0008170	N-methyltransferase activity	5/407	97/18367	0.0644840025945892	0.380513709004107	METTL21C/SUV39H1/EZH2/SETD4/WDR5	5
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/407	19/18367	0.0653652382520021	0.382269920134477	LTBP1/ACVR2A	2
GO:0005518	collagen binding	4/407	69/18367	0.066838966561099	0.387429407942654	COL14A1/MRC2/P3H1/ADGRG1	4
GO:0017124	SH3 domain binding	6/407	130/18367	0.0694727042418386	0.396353939077447	LRP2/SYNJ2/SH3BGRL2/GJA1/ABL1/PLSCR4	6
GO:0140097	catalytic activity, acting on DNA	9/407	229/18367	0.0695888595326816	0.396353939077447	DNMT3A/POLI/SMARCA1/WRNIP1/PCNA/BLM/TDG/MCM5/HELLS	9
GO:0031681	G-protein beta-subunit binding	2/407	20/18367	0.0715942161468879	0.400805227147108	GNG12/GNG10	2
GO:0070300	phosphatidic acid binding	2/407	20/18367	0.0715942161468879	0.400805227147108	MICALL1/RAPGEF2	2
GO:0016779	nucleotidyltransferase activity	6/407	132/18367	0.0736046548964965	0.408568211501739	POLR1A/CDS1/POLI/ABL1/POLR3F/COASY	6
GO:0008235	metalloexopeptidase activity	4/407	72/18367	0.0756387120608149	0.416330726049023	MMP15/TFRC/MMP14/RNPEP	4
GO:0008201	heparin binding	7/407	166/18367	0.0767461075908831	0.418804298342472	CCDC80/PRSS57/ADAMTS1/NRP1/FGFR2/SERPINE2/ADGRG1	7
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	2/407	21/18367	0.0780062967905062	0.418804298342472	AGPAT4/MBOAT7	2
GO:0051010	microtubule plus-end binding	2/407	21/18367	0.0780062967905062	0.418804298342472	DST/CLIP1	2
GO:0005254	chloride channel activity	4/407	74/18367	0.0818130144997729	0.422951765149662	GABRE/ANO2/CLDN4/ANO6	4
GO:0019905	syntaxin binding	4/407	74/18367	0.0818130144997729	0.422951765149662	UNC13B/SYT1/ABL1/HECTD3	4
GO:0008093	cytoskeletal anchor activity	2/407	22/18367	0.0845903530299324	0.422951765149662	GAS2L3/EPB41L3	2
GO:0008649	rRNA methyltransferase activity	2/407	22/18367	0.0845903530299324	0.422951765149662	MRM1/NSUN4	2
GO:0017075	syntaxin-1 binding	2/407	22/18367	0.0845903530299324	0.422951765149662	UNC13B/SYT1	2
GO:0030742	GTP-dependent protein binding	2/407	22/18367	0.0845903530299324	0.422951765149662	UNC13B/RAB5B	2
GO:0055106	ubiquitin-protein transferase regulator activity	2/407	22/18367	0.0845903530299324	0.422951765149662	FZR1/TRIB1	2
GO:0072349	modified amino acid transmembrane transporter activity	2/407	22/18367	0.0845903530299324	0.422951765149662	SLC7A11/GJA1	2
GO:0140102	catalytic activity, acting on a rRNA	2/407	22/18367	0.0845903530299324	0.422951765149662	MRM1/NSUN4	2
GO:0019955	cytokine binding	6/407	139/18367	0.0891454982541113	0.44235076785184	LTBP1/NRP1/ACKR2/ITGAV/PRLR/IL6ST	6
GO:0017116	single-stranded DNA helicase activity	2/407	23/18367	0.0913356587875068	0.443147085228274	WRNIP1/MCM5	2
GO:0042171	lysophosphatidic acid acyltransferase activity	2/407	23/18367	0.0913356587875068	0.443147085228274	AGPAT4/MBOAT7	2
GO:0071617	lysophospholipid acyltransferase activity	2/407	23/18367	0.0913356587875068	0.443147085228274	AGPAT4/MBOAT7	2
GO:0000149	SNARE binding	5/407	110/18367	0.0977637811302756	0.465421689148254	UNC13B/SYT1/ABL1/HECTD3/SEC24C	5
GO:0008171	O-methyltransferase activity	2/407	24/18367	0.0982318768217857	0.465421689148254	MRM1/ICMT	2
GO:0050431	transforming growth factor beta binding	2/407	24/18367	0.0982318768217857	0.465421689148254	LTBP1/ITGAV	2
GO:0008194	UDP-glycosyltransferase activity	6/407	143/18367	0.0987688775444387	0.465421689148254	UGGT2/CHPF/GCNT2/GALNT11/EXTL2/GYG1	6
GO:0004222	metalloendopeptidase activity	5/407	111/18367	0.100626100867983	0.467447489847724	MMP15/TLL1/ADAMTS1/MMP14/SPRTN	5
GO:0008094	ATP-dependent activity, acting on DNA	5/407	111/18367	0.100626100867983	0.467447489847724	SMARCA1/WRNIP1/BLM/MCM5/HELLS	5
GO:0005112	Notch binding	2/407	25/18367	0.105269046831844	0.482176403320685	AAK1/GALNT11	2
GO:0005160	transforming growth factor beta receptor binding	2/407	25/18367	0.105269046831844	0.482176403320685	BAMBI/FERMT2	2
GO:0004843	thiol-dependent deubiquitinase	5/407	113/18367	0.106475211769994	0.484314331314905	USP43/USP40/OTUD3/USP5/USP27X	5
GO:0008146	sulfotransferase activity	3/407	52/18367	0.108061472833751	0.484439878922267	HS6ST2/CHST11/CHST14	3
GO:0016597	amino acid binding	3/407	52/18367	0.108061472833751	0.484439878922267	SLC1A3/GLDC/SHMT1	3
GO:0003774	cytoskeletal motor activity	5/407	114/18367	0.109461224550375	0.484439878922267	CENPE/MYO9A/KIF11/DYNC1H1/MYO1C	5
GO:0101005	deubiquitinase activity	5/407	114/18367	0.109461224550375	0.484439878922267	USP43/USP40/OTUD3/USP5/USP27X	5
GO:0051015	actin filament binding	8/407	217/18367	0.110525123082263	0.485865473952229	GAS2L3/ABL1/FERMT2/CYFIP1/DMD/MYO1C/EGFR/LIMA1	8
GO:0051020	GTPase binding	10/407	291/18367	0.114094875219161	0.498214288457002	UNC13B/WASF1/CDC42EP4/HACE1/MICALL1/RAB11FIP3/YIPF1/CYFIP1/MYO1C/STK19	10
GO:0008374	O-acyltransferase activity	3/407	54/18367	0.117544085524201	0.502513409721903	AGPAT4/CPT1C/MBOAT7	3
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	2/407	27/18367	0.119728217234499	0.502513409721903	SYNJ2/INPP4A	2
GO:0043425	bHLH transcription factor binding	2/407	27/18367	0.119728217234499	0.502513409721903	FHL2/BHLHE41	2
GO:0045499	chemorepellent activity	2/407	27/18367	0.119728217234499	0.502513409721903	SEMA4G/SEMA6A	2
GO:0051393	alpha-actinin binding	2/407	27/18367	0.119728217234499	0.502513409721903	PPARG/DAG1	2
GO:0051959	dynein light intermediate chain binding	2/407	27/18367	0.119728217234499	0.502513409721903	RAB11FIP3/DYNC1H1	2
GO:0060090	molecular adaptor activity	12/407	369/18367	0.120449779124181	0.502513409721903	WWC1/IPPK/COL14A1/GAS2L3/UBXN8/TJP2/EPB41L3/WWC3/MPP7/FKBP4/PSMG1/SHC1	12
GO:0003714	transcription corepressor activity	7/407	187/18367	0.122786971337173	0.509021938138282	DNMT3A/CBFA2T2/YAP1/KDM5B/RBFOX2/EZH2/FHL2	7
GO:0042562	hormone binding	4/407	86/18367	0.123703836941398	0.509597567274313	LRP2/PRLR/EGFR/SHC1	4
GO:0004197	cysteine-type endopeptidase activity	5/407	119/18367	0.124988974737602	0.51167361533206	CTSV/USP40/BLMH/USP5/CAPN15	5
GO:0046875	ephrin receptor binding	2/407	28/18367	0.127132079292126	0.512521093445911	ABL1/SHC1	2
GO:0070325	lipoprotein particle receptor binding	2/407	28/18367	0.127132079292126	0.512521093445911	SYT1/LRP1	2
GO:0005253	anion channel activity	4/407	87/18367	0.127543417147609	0.512521093445911	GABRE/ANO2/CLDN4/ANO6	4
GO:0008237	metallopeptidase activity	7/407	190/18367	0.130316749597032	0.520472384061317	MMP15/TLL1/ADAMTS1/TFRC/MMP14/RNPEP/SPRTN	7
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3/407	57/18367	0.132319743032953	0.525269282948997	TXNRD3/PCYOX1/ERO1B	3
GO:0004386	helicase activity	6/407	156/18367	0.13361455538884	0.526232714684366	SMARCA1/WRNIP1/BLM/DDX3Y/MCM5/HELLS	6
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	2/407	29/18367	0.134640595124528	0.526232714684366	AIFM2/MTHFD2L	2
GO:0015297	antiporter activity	4/407	89/18367	0.135369984389778	0.526232714684366	SLC7A11/SLC26A2/SLC25A11/SLC25A4	4
GO:1901681	sulfur compound binding	9/407	265/18367	0.135943470644488	0.526232714684366	CCDC80/PRSS57/ADAMTS1/LRP1/ACBD4/NRP1/FGFR2/SERPINE2/ADGRG1	9
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/407	58/18367	0.137382891925232	0.526232714684366	SLC27A2/SLC27A6/SLC16A1	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3/407	58/18367	0.137382891925232	0.526232714684366	COX10/GSTA4/MMAB	3
GO:0005539	glycosaminoglycan binding	8/407	230/18367	0.140017455735868	0.533206008761589	CCDC80/PRSS57/ADAMTS1/NRP1/FGFR2/SERPINE2/EXTL2/ADGRG1	8
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/407	30/18367	0.142245522087766	0.535464465330382	SLC26A2/SLC25A11	2
GO:0070566	adenylyltransferase activity	2/407	30/18367	0.142245522087766	0.535464465330382	ABL1/COASY	2
GO:0019783	ubiquitin-like protein-specific protease activity	5/407	125/18367	0.14487529761297	0.542247542494258	USP43/USP40/OTUD3/USP5/USP27X	5
GO:0016757	glycosyltransferase activity	9/407	270/18367	0.147127555473724	0.542596679729572	UGGT2/CHPF/GCNT2/PIGV/TMTC2/TMTC3/GALNT11/EXTL2/GYG1	9
GO:0043130	ubiquitin binding	4/407	92/18367	0.147463649695863	0.542596679729572	HGS/USP5/SPRTN/RNF19B	4
GO:0051213	dioxygenase activity	4/407	92/18367	0.147463649695863	0.542596679729572	P3H2/PLOD1/KDM5B/P3H1	4
GO:0008242	omega peptidase activity	5/407	126/18367	0.148315471127668	0.542596679729572	USP43/USP40/OTUD3/USP5/USP27X	5
GO:0016411	acylglycerol O-acyltransferase activity	2/407	31/18367	0.149938929818401	0.542596679729572	AGPAT4/MBOAT7	2
GO:0090482	vitamin transmembrane transporter activity	2/407	31/18367	0.149938929818401	0.542596679729572	SLC19A3/SLC2A1	2
GO:0004674	protein serine/threonine kinase activity	12/407	386/18367	0.151272449326835	0.544414584115809	PRKCH/LTBP1/ACVR2A/AAK1/NRK/CDKL3/SIK2/IRAK4/CAMK2G/STK3/STK19/EGFR	12
GO:0005507	copper ion binding	3/407	61/18367	0.152953786400299	0.544482228761933	F5/ATP7B/GPC1	3
GO:0015179	L-amino acid transmembrane transporter activity	3/407	61/18367	0.152953786400299	0.544482228761933	SLC7A11/SLC1A3/SLC38A9	3
GO:0031624	ubiquitin conjugating enzyme binding	2/407	32/18367	0.157713190497863	0.552417859765242	DCUN1D3/RNF19B	2
GO:0050699	WW domain binding	2/407	32/18367	0.157713190497863	0.552417859765242	PRRG4/RAPGEF2	2
GO:0140658	ATP-dependent chromatin remodeler activity	2/407	32/18367	0.157713190497863	0.552417859765242	SMARCA1/HELLS	2
GO:0005516	calmodulin binding	7/407	201/18367	0.159812377632455	0.555350013230396	ASPM/UNC13B/SYT1/TJP1/CAMK2G/MYO1C/EGFR	7
GO:0016874	ligase activity	6/407	165/18367	0.160711468116648	0.555350013230396	TARS2/SLC27A2/SLC27A6/LIPT2/HARS2/ACSF2	6
GO:0004175	endopeptidase activity	13/407	430/18367	0.161093896967596	0.555350013230396	PLAU/MMP15/PRSS57/TLL1/ADAMTS1/CTSV/USP40/BLMH/MMP14/USP5/PRSS8/CAPN15/SPRTN	13
GO:0019956	chemokine binding	2/407	33/18367	0.165560969393239	0.567761439542259	ACKR2/ITGAV	2
GO:0016836	hydro-lyase activity	3/407	64/18367	0.169048456401473	0.57670176532794	ECHDC3/ENOSF1/CA8	3
GO:0052866	phosphatidylinositol phosphate phosphatase activity	2/407	34/18367	0.17347521566707	0.584197778042101	SYNJ2/INPP4A	2
GO:0030145	manganese ion binding	3/407	65/18367	0.174519056918535	0.584197778042101	ABL1/EXTL2/GYG1	3
GO:0000217	DNA secondary structure binding	2/407	36/18367	0.189476273161699	0.584197778042101	ABL1/BLM	2
GO:0042805	actinin binding	2/407	36/18367	0.189476273161699	0.584197778042101	PPARG/DAG1	2
GO:0097718	disordered domain specific binding	2/407	36/18367	0.189476273161699	0.584197778042101	GJA1/PPIL1	2
GO:0004252	serine-type endopeptidase activity	6/407	174/18367	0.189962522866125	0.584197778042101	PLAU/PRSS57/TLL1/CTSV/MMP14/PRSS8	6
GO:0003777	microtubule motor activity	3/407	69/18367	0.196869884053841	0.584197778042101	CENPE/KIF11/DYNC1H1	3
GO:0005109	frizzled binding	2/407	37/18367	0.197550323095788	0.584197778042101	BAMBI/RNF43	2
GO:0015035	protein-disulfide reductase activity	2/407	37/18367	0.197550323095788	0.584197778042101	TXNRD3/ERO1B	2
GO:0016409	palmitoyltransferase activity	2/407	37/18367	0.197550323095788	0.584197778042101	CPT1C/ZDHHC13	2
GO:0046915	transition metal ion transmembrane transporter activity	2/407	37/18367	0.197550323095788	0.584197778042101	ATP7B/SLC39A1	2
GO:0004300	enoyl-CoA hydratase activity	1/407	10/18367	0.200797300373992	0.584197778042101	ECHDC3	1
GO:0004955	prostaglandin receptor activity	1/407	10/18367	0.200797300373992	0.584197778042101	PPARG	1
GO:0005528	FK506 binding	1/407	10/18367	0.200797300373992	0.584197778042101	FKBP4	1
GO:0008172	S-methyltransferase activity	1/407	10/18367	0.200797300373992	0.584197778042101	DNMT3A	1
GO:0016595	glutamate binding	1/407	10/18367	0.200797300373992	0.584197778042101	SLC1A3	1
GO:0016783	sulfurtransferase activity	1/407	10/18367	0.200797300373992	0.584197778042101	MPST	1
GO:0016803	ether hydrolase activity	1/407	10/18367	0.200797300373992	0.584197778042101	RNPEP	1
GO:0016868	intramolecular transferase activity, phosphotransferases	1/407	10/18367	0.200797300373992	0.584197778042101	PMM1	1
GO:0017002	activin-activated receptor activity	1/407	10/18367	0.200797300373992	0.584197778042101	ACVR2A	1
GO:0019531	oxalate transmembrane transporter activity	1/407	10/18367	0.200797300373992	0.584197778042101	SLC26A2	1
GO:0031419	cobalamin binding	1/407	10/18367	0.200797300373992	0.584197778042101	MMAB	1
GO:0032356	oxidized DNA binding	1/407	10/18367	0.200797300373992	0.584197778042101	BLM	1
GO:0034713	type I transforming growth factor beta receptor binding	1/407	10/18367	0.200797300373992	0.584197778042101	FERMT2	1
GO:0035612	AP-2 adaptor complex binding	1/407	10/18367	0.200797300373992	0.584197778042101	AAK1	1
GO:0046030	inositol trisphosphate phosphatase activity	1/407	10/18367	0.200797300373992	0.584197778042101	INPP4A	1
GO:0046974	histone methyltransferase activity (H3-K9 specific)	1/407	10/18367	0.200797300373992	0.584197778042101	SUV39H1	1
GO:0047760	butyrate-CoA ligase activity	1/407	10/18367	0.200797300373992	0.584197778042101	ACSF2	1
GO:0051880	G-quadruplex DNA binding	1/407	10/18367	0.200797300373992	0.584197778042101	BLM	1
GO:0070567	cytidylyltransferase activity	1/407	10/18367	0.200797300373992	0.584197778042101	CDS1	1
GO:0097027	ubiquitin-protein transferase activator activity	1/407	10/18367	0.200797300373992	0.584197778042101	FZR1	1
GO:0045296	cadherin binding	10/407	332/18367	0.203695251870597	0.584197778042101	TJP1/CDH1/ITGA6/TJP2/MICALL1/CTNND1/UBAP2/MPP7/EGFR/LIMA1	10
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2/407	38/18367	0.205665301224443	0.584197778042101	PPIL1/FKBP4	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/407	38/18367	0.205665301224443	0.584197778042101	SLC7A11/SLC38A9	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	2/407	38/18367	0.205665301224443	0.584197778042101	DCUN1D3/RNF19B	2
GO:0048029	monosaccharide binding	3/407	71/18367	0.208295391372933	0.584197778042101	P3H2/PLOD1/P3H1	3
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	2/407	39/18367	0.213815447253796	0.584197778042101	POLR1A/POLR3F	2
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	2/407	39/18367	0.213815447253796	0.584197778042101	FERMT2/RACGAP1	2
GO:0003678	DNA helicase activity	3/407	72/18367	0.214063073082156	0.584197778042101	WRNIP1/BLM/MCM5	3
GO:0004954	prostanoid receptor activity	1/407	11/18367	0.218516726137885	0.584197778042101	PPARG	1
GO:0005247	voltage-gated chloride channel activity	1/407	11/18367	0.218516726137885	0.584197778042101	ANO6	1
GO:0005347	ATP transmembrane transporter activity	1/407	11/18367	0.218516726137885	0.584197778042101	SLC25A4	1
GO:0008503	benzodiazepine receptor activity	1/407	11/18367	0.218516726137885	0.584197778042101	GABRE	1
GO:0016801	hydrolase activity, acting on ether bonds	1/407	11/18367	0.218516726137885	0.584197778042101	RNPEP	1
GO:0016832	aldehyde-lyase activity	1/407	11/18367	0.218516726137885	0.584197778042101	SHMT1	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	1/407	11/18367	0.218516726137885	0.584197778042101	GLCE	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/407	11/18367	0.218516726137885	0.584197778042101	TRIB1	1
GO:0032404	mismatch repair complex binding	1/407	11/18367	0.218516726137885	0.584197778042101	PCNA	1
GO:0035673	oligopeptide transmembrane transporter activity	1/407	11/18367	0.218516726137885	0.584197778042101	GJA1	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	1/407	11/18367	0.218516726137885	0.584197778042101	TXNRD3	1
GO:0048407	platelet-derived growth factor binding	1/407	11/18367	0.218516726137885	0.584197778042101	COL4A1	1
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	1/407	11/18367	0.218516726137885	0.584197778042101	SYNJ2	1
GO:1901474	azole transmembrane transporter activity	1/407	11/18367	0.218516726137885	0.584197778042101	SLC19A3	1
GO:0000287	magnesium ion binding	7/407	221/18367	0.220178150959643	0.586246702758399	ENOSF1/ABL1/SIK2/ARL3/TDG/IRAK4/STK3	7
GO:0003925	G protein activity	2/407	40/18367	0.221995234901225	0.588691817248189	RAC3/RAB5B	2
GO:0004812	aminoacyl-tRNA ligase activity	2/407	41/18367	0.230199364395875	0.603122334717192	TARS2/HARS2	2
GO:0016859	cis-trans isomerase activity	2/407	41/18367	0.230199364395875	0.603122334717192	PPIL1/FKBP4	2
GO:0016875	ligase activity, forming carbon-oxygen bonds	2/407	41/18367	0.230199364395875	0.603122334717192	TARS2/HARS2	2
GO:0000340	RNA 7-methylguanosine cap binding	1/407	12/18367	0.235844231719813	0.605795967750893	CYFIP1	1
GO:0005024	transforming growth factor beta-activated receptor activity	1/407	12/18367	0.235844231719813	0.605795967750893	LTBP1	1
GO:0005165	neurotrophin receptor binding	1/407	12/18367	0.235844231719813	0.605795967750893	SHC1	1
GO:0005527	macrolide binding	1/407	12/18367	0.235844231719813	0.605795967750893	FKBP4	1
GO:0061578	Lys63-specific deubiquitinase activity	1/407	12/18367	0.235844231719813	0.605795967750893	USP27X	1
GO:0008307	structural constituent of muscle	2/407	42/18367	0.238422755195311	0.607653325497776	DAG1/DMD	2
GO:0015036	disulfide oxidoreductase activity	2/407	42/18367	0.238422755195311	0.607653325497776	TXNRD3/ERO1B	2
GO:0034062	5'-3' RNA polymerase activity	2/407	43/18367	0.24666053891246	0.6122975739171	POLR1A/POLR3F	2
GO:0097747	RNA polymerase activity	2/407	43/18367	0.24666053891246	0.6122975739171	POLR1A/POLR3F	2
GO:0008236	serine-type peptidase activity	6/407	191/18367	0.250054076023261	0.6122975739171	PLAU/PRSS57/TLL1/CTSV/MMP14/PRSS8	6
GO:0002161	aminoacyl-tRNA editing activity	1/407	13/18367	0.252788464772935	0.6122975739171	TARS2	1
GO:0008271	secondary active sulfate transmembrane transporter activity	1/407	13/18367	0.252788464772935	0.6122975739171	SLC26A2	1
GO:0016594	glycine binding	1/407	13/18367	0.252788464772935	0.6122975739171	GLDC	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	1/407	13/18367	0.252788464772935	0.6122975739171	TXNRD3	1
GO:0022851	GABA-gated chloride ion channel activity	1/407	13/18367	0.252788464772935	0.6122975739171	GABRE	1
GO:0031404	chloride ion binding	1/407	13/18367	0.252788464772935	0.6122975739171	TDG	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	1/407	13/18367	0.252788464772935	0.6122975739171	SYNJ2	1
GO:0140299	small molecule sensor activity	1/407	13/18367	0.252788464772935	0.6122975739171	SYT1	1
GO:0004842	ubiquitin-protein transferase activity	12/407	433/18367	0.254628373791334	0.6122975739171	RNF43/HACE1/TRIM24/HECTD3/RMND5B/TRIM27/RSPRY1/MED31/DTX4/CUL2/KLHL42/RNF19B	12
GO:0001784	phosphotyrosine residue binding	2/407	44/18367	0.254908052447125	0.6122975739171	ABL1/SHC1	2
GO:0008375	acetylglucosaminyltransferase activity	2/407	44/18367	0.254908052447125	0.6122975739171	GCNT2/EXTL2	2
GO:0022839	ion gated channel activity	2/407	44/18367	0.254908052447125	0.6122975739171	ANO2/ANO6	2
GO:0016835	carbon-oxygen lyase activity	3/407	79/18367	0.25526761200859	0.6122975739171	ECHDC3/ENOSF1/CA8	3
GO:0140297	DNA-binding transcription factor binding	11/407	394/18367	0.259335011548546	0.6122975739171	ELK1/PPARG/TACC2/YAP1/TRIM24/RBFOX2/PCNA/TDG/CEBPA/FHL2/BHLHE41	11
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2/407	45/18367	0.263160831316512	0.6122975739171	ABL1/PTK2	2
GO:0017171	serine hydrolase activity	6/407	195/18367	0.264928881348618	0.6122975739171	PLAU/PRSS57/TLL1/CTSV/MMP14/PRSS8	6
GO:0016829	lyase activity	6/407	196/18367	0.268683033551288	0.6122975739171	ECHDC3/ENOSF1/CA8/GLDC/SHMT1/GGCX	6
GO:0019902	phosphatase binding	6/407	196/18367	0.268683033551288	0.6122975739171	MET/PPP1R32/SH2D4A/HMGCR/PTK2/EGFR	6
GO:0004089	carbonate dehydratase activity	1/407	14/18367	0.26935788260215	0.6122975739171	CA8	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	1/407	14/18367	0.26935788260215	0.6122975739171	SHC1	1
GO:0008474	palmitoyl-(protein) hydrolase activity	1/407	14/18367	0.26935788260215	0.6122975739171	ABHD12	1
GO:0015562	efflux transmembrane transporter activity	1/407	14/18367	0.26935788260215	0.6122975739171	GJA1	1
GO:0032977	membrane insertase activity	1/407	14/18367	0.26935788260215	0.6122975739171	EMC1	1
GO:0036041	long-chain fatty acid binding	1/407	14/18367	0.26935788260215	0.6122975739171	PPARG	1
GO:0098599	palmitoyl hydrolase activity	1/407	14/18367	0.26935788260215	0.6122975739171	ABHD12	1
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	1/407	14/18367	0.26935788260215	0.6122975739171	SYNJ2	1
GO:0106310	protein serine kinase activity	10/407	360/18367	0.277838631595737	0.6122975739171	PRKCH/AAK1/STK25/NRK/CDKL3/SIK2/IRAK4/CAMK2G/STK3/STK19	10
GO:0015291	secondary active transmembrane transporter activity	7/407	240/18367	0.283757259804571	0.6122975739171	SLC7A11/SLC1A3/SLC22A11/SLC26A2/SLC25A11/SLC16A1/SLC25A4	7
GO:0015171	amino acid transmembrane transporter activity	3/407	84/18367	0.285332245822018	0.6122975739171	SLC7A11/SLC1A3/SLC38A9	3
GO:0001846	opsonin binding	1/407	15/18367	0.285560756343823	0.6122975739171	ITGAV	1
GO:0004549	tRNA-specific ribonuclease activity	1/407	15/18367	0.285560756343823	0.6122975739171	ELAC2	1
GO:0004559	alpha-mannosidase activity	1/407	15/18367	0.285560756343823	0.6122975739171	MANEA	1
GO:0004953	icosanoid receptor activity	1/407	15/18367	0.285560756343823	0.6122975739171	PPARG	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/407	15/18367	0.285560756343823	0.6122975739171	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/407	15/18367	0.285560756343823	0.6122975739171	SLC22A11	1
GO:0005545	1-phosphatidylinositol binding	1/407	15/18367	0.285560756343823	0.6122975739171	ZFYVE9	1
GO:0034483	heparan sulfate sulfotransferase activity	1/407	15/18367	0.285560756343823	0.6122975739171	HS6ST2	1
GO:0047372	acylglycerol lipase activity	1/407	15/18367	0.285560756343823	0.6122975739171	ABHD12	1
GO:0048185	activin binding	1/407	15/18367	0.285560756343823	0.6122975739171	ACVR2A	1
GO:0050998	nitric-oxide synthase binding	1/407	15/18367	0.285560756343823	0.6122975739171	DMD	1
GO:0071933	Arp2/3 complex binding	1/407	15/18367	0.285560756343823	0.6122975739171	WASF1	1
GO:1904680	peptide transmembrane transporter activity	1/407	15/18367	0.285560756343823	0.6122975739171	GJA1	1
GO:0070888	E-box binding	2/407	48/18367	0.287908959685989	0.6122975739171	PPARG/BHLHE41	2
GO:0003712	transcription coregulator activity	13/407	489/18367	0.290315287719177	0.6122975739171	WWC1/ELK1/DNMT3A/CBFA2T2/YAP1/KDM5B/TRIM24/ABL1/RBFOX2/TRIM27/MED31/EZH2/FHL2	13
GO:0008013	beta-catenin binding	3/407	85/18367	0.291384108563191	0.6122975739171	GJA1/CDH1/GLI3	3
GO:0050660	flavin adenine dinucleotide binding	3/407	85/18367	0.291384108563191	0.6122975739171	TXNRD3/AIFM2/ERO1B	3
GO:0000900	translation repressor activity, mRNA regulatory element binding	1/407	16/18367	0.301405175053939	0.6122975739171	SHMT1	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/407	16/18367	0.301405175053939	0.6122975739171	CAPN15	1
GO:0004698	calcium-dependent protein kinase C activity	1/407	16/18367	0.301405175053939	0.6122975739171	PRKCH	1
GO:0005159	insulin-like growth factor receptor binding	1/407	16/18367	0.301405175053939	0.6122975739171	SHC1	1
GO:0005283	amino acid:sodium symporter activity	1/407	16/18367	0.301405175053939	0.6122975739171	SLC1A3	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/407	16/18367	0.301405175053939	0.6122975739171	SLC22A11	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/407	16/18367	0.301405175053939	0.6122975739171	SLC25A11	1
GO:0015923	mannosidase activity	1/407	16/18367	0.301405175053939	0.6122975739171	MANEA	1
GO:0022841	potassium ion leak channel activity	1/407	16/18367	0.301405175053939	0.6122975739171	TMEM175	1
GO:0032183	SUMO binding	1/407	16/18367	0.301405175053939	0.6122975739171	TDG	1
GO:0035497	cAMP response element binding	1/407	16/18367	0.301405175053939	0.6122975739171	E4F1	1
GO:0070402	NADPH binding	1/407	16/18367	0.301405175053939	0.6122975739171	HMGCR	1
GO:0070492	oligosaccharide binding	1/407	16/18367	0.301405175053939	0.6122975739171	CHID1	1
GO:0140327	flippase activity	1/407	16/18367	0.301405175053939	0.6122975739171	TMEM30B	1
GO:1990380	Lys48-specific deubiquitinase activity	1/407	16/18367	0.301405175053939	0.6122975739171	USP27X	1
GO:0015485	cholesterol binding	2/407	50/18367	0.304360551681071	0.6122975739171	PROM2/SCARB2	2
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/407	50/18367	0.304360551681071	0.6122975739171	PCNA/TDG	2
GO:0048306	calcium-dependent protein binding	3/407	88/18367	0.309586171431219	0.6122975739171	SYT1/RAC3/CLN3	3
GO:0004659	prenyltransferase activity	1/407	17/18367	0.316899049706713	0.6122975739171	COX10	1
GO:0004697	protein kinase C activity	1/407	17/18367	0.316899049706713	0.6122975739171	PRKCH	1
GO:0005149	interleukin-1 receptor binding	1/407	17/18367	0.316899049706713	0.6122975739171	IRAK4	1
GO:0008308	voltage-gated anion channel activity	1/407	17/18367	0.316899049706713	0.6122975739171	ANO6	1
GO:0008381	mechanosensitive ion channel activity	1/407	17/18367	0.316899049706713	0.6122975739171	TMC5	1
GO:0015095	magnesium ion transmembrane transporter activity	1/407	17/18367	0.316899049706713	0.6122975739171	ZDHHC13	1
GO:0015108	chloride transmembrane transporter activity	1/407	17/18367	0.316899049706713	0.6122975739171	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/407	17/18367	0.316899049706713	0.6122975739171	SLC38A9	1
GO:0016854	racemase and epimerase activity	1/407	17/18367	0.316899049706713	0.6122975739171	GLCE	1
GO:0031420	alkali metal ion binding	1/407	17/18367	0.316899049706713	0.6122975739171	TDG	1
GO:0034185	apolipoprotein binding	1/407	17/18367	0.316899049706713	0.6122975739171	LRP1	1
GO:0043395	heparan sulfate proteoglycan binding	1/407	17/18367	0.316899049706713	0.6122975739171	LRP1	1
GO:0046965	retinoid X receptor binding	1/407	17/18367	0.316899049706713	0.6122975739171	PPARG	1
GO:0052745	inositol phosphate phosphatase activity	1/407	17/18367	0.316899049706713	0.6122975739171	INPP4A	1
GO:0070628	proteasome binding	1/407	17/18367	0.316899049706713	0.6122975739171	PSMG1	1
GO:0019787	ubiquitin-like protein transferase activity	12/407	458/18367	0.317878254418221	0.612383107776279	RNF43/HACE1/TRIM24/HECTD3/RMND5B/TRIM27/RSPRY1/MED31/DTX4/CUL2/KLHL42/RNF19B	12
GO:0004879	nuclear receptor activity	2/407	52/18367	0.320741499358272	0.612494699940724	PPARG/NR2F2	2
GO:0016830	carbon-carbon lyase activity	2/407	52/18367	0.320741499358272	0.612494699940724	SHMT1/GGCX	2
GO:0098531	ligand-activated transcription factor activity	2/407	52/18367	0.320741499358272	0.612494699940724	PPARG/NR2F2	2
GO:0000295	adenine nucleotide transmembrane transporter activity	1/407	18/18367	0.332050117105589	0.621408076297602	SLC25A4	1
GO:0004438	phosphatidylinositol-3-phosphatase activity	1/407	18/18367	0.332050117105589	0.621408076297602	SYNJ2	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	1/407	18/18367	0.332050117105589	0.621408076297602	SLC25A4	1
GO:0008569	minus-end-directed microtubule motor activity	1/407	18/18367	0.332050117105589	0.621408076297602	DYNC1H1	1
GO:0031435	mitogen-activated protein kinase kinase kinase binding	1/407	18/18367	0.332050117105589	0.621408076297602	MARVELD3	1
GO:0099095	ligand-gated anion channel activity	1/407	18/18367	0.332050117105589	0.621408076297602	GABRE	1
GO:0140597	protein carrier activity	1/407	18/18367	0.332050117105589	0.621408076297602	EMC1	1
GO:0030674	protein-macromolecule adaptor activity	8/407	296/18367	0.33461203813732	0.624418475726338	COL14A1/GAS2L3/UBXN8/TJP2/EPB41L3/MPP7/FKBP4/SHC1	8
GO:0005543	phospholipid binding	12/407	466/18367	0.338907390069379	0.627816508586626	ZFYVE9/UNC13B/ARL6/SYT1/HGS/SCARB2/FERMT2/RACGAP1/MICALL1/MYOF/RAPGEF2/SHC1	12
GO:0005080	protein kinase C binding	2/407	55/18367	0.345125622286291	0.627816508586626	ABL1/ITGAV	2
GO:0030170	pyridoxal phosphate binding	2/407	55/18367	0.345125622286291	0.627816508586626	GLDC/SHMT1	2
GO:0000339	RNA cap binding	1/407	19/18367	0.346865943708566	0.627816508586626	CYFIP1	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/407	19/18367	0.346865943708566	0.627816508586626	GALNT11	1
GO:0004890	GABA-A receptor activity	1/407	19/18367	0.346865943708566	0.627816508586626	GABRE	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1/407	19/18367	0.346865943708566	0.627816508586626	MTHFD2L	1
GO:0022840	leak channel activity	1/407	19/18367	0.346865943708566	0.627816508586626	TMEM175	1
GO:0022842	narrow pore channel activity	1/407	19/18367	0.346865943708566	0.627816508586626	TMEM175	1
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	1/407	19/18367	0.346865943708566	0.627816508586626	SYNJ2	1
GO:0002020	protease binding	4/407	135/18367	0.350807731640845	0.627816508586626	LRP1/NFRKB/ADAMTSL4/ITGAV	4
GO:0045309	protein phosphorylated amino acid binding	2/407	56/18367	0.353192348273095	0.627816508586626	ABL1/SHC1	2
GO:0070279	vitamin B6 binding	2/407	56/18367	0.353192348273095	0.627816508586626	GLDC/SHMT1	2
GO:0061630	ubiquitin protein ligase activity	8/407	304/18367	0.361270623596688	0.627816508586626	RNF43/HACE1/TRIM24/RMND5B/TRIM27/MED31/DTX4/RNF19B	8
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	1/407	20/18367	0.361353929369707	0.627816508586626	EZH2	1
GO:0001972	retinoic acid binding	1/407	20/18367	0.361353929369707	0.627816508586626	NR2F2	1
GO:0003756	protein disulfide isomerase activity	1/407	20/18367	0.361353929369707	0.627816508586626	ERO1B	1
GO:0016018	cyclosporin A binding	1/407	20/18367	0.361353929369707	0.627816508586626	PPIL1	1
GO:0016500	protein-hormone receptor activity	1/407	20/18367	0.361353929369707	0.627816508586626	LGR5	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/407	20/18367	0.361353929369707	0.627816508586626	GLDC	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/407	20/18367	0.361353929369707	0.627816508586626	CDS1	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	1/407	20/18367	0.361353929369707	0.627816508586626	ERO1B	1
GO:0030296	protein tyrosine kinase activator activity	1/407	20/18367	0.361353929369707	0.627816508586626	ERBB3	1
GO:0030506	ankyrin binding	1/407	20/18367	0.361353929369707	0.627816508586626	CDH1	1
GO:0031690	adrenergic receptor binding	1/407	20/18367	0.361353929369707	0.627816508586626	RAPGEF2	1
GO:0050145	nucleoside monophosphate kinase activity	1/407	20/18367	0.361353929369707	0.627816508586626	TJP2	1
GO:0004896	cytokine receptor activity	3/407	97/18367	0.364237758109569	0.631152728999386	ACKR2/PRLR/IL6ST	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	6/407	222/18367	0.369613803323321	0.633934171917852	AGPAT4/CPT1C/MBOAT7/ZDHHC13/LIPT2/LIPT1	6
GO:0004867	serine-type endopeptidase inhibitor activity	3/407	98/18367	0.370282402218861	0.633934171917852	SERPINE2/ITIH5/SPINT1	3
GO:0005243	gap junction channel activity	1/407	21/18367	0.375521310998667	0.633934171917852	GJA1	1
GO:0005385	zinc ion transmembrane transporter activity	1/407	21/18367	0.375521310998667	0.633934171917852	SLC39A1	1
GO:0015216	purine nucleotide transmembrane transporter activity	1/407	21/18367	0.375521310998667	0.633934171917852	SLC25A4	1
GO:0015662	P-type ion transporter activity	1/407	21/18367	0.375521310998667	0.633934171917852	ATP7B	1
GO:0070577	lysine-acetylated histone binding	1/407	21/18367	0.375521310998667	0.633934171917852	TRIM24	1
GO:0140033	acetylation-dependent protein binding	1/407	21/18367	0.375521310998667	0.633934171917852	TRIM24	1
GO:0140358	P-type transmembrane transporter activity	1/407	21/18367	0.375521310998667	0.633934171917852	ATP7B	1
GO:0140416	transcription regulator inhibitor activity	1/407	21/18367	0.375521310998667	0.633934171917852	ID4	1
GO:0022853	active ion transmembrane transporter activity	7/407	267/18367	0.380006858660116	0.639857306998395	SLC7A11/ATP7B/SLC1A3/SLC22A11/SLC26A2/SLC25A11/SLC25A4	7
GO:0001786	phosphatidylserine binding	2/407	60/18367	0.385085834954898	0.640805863873676	SYT1/SCARB2	2
GO:0032934	sterol binding	2/407	60/18367	0.385085834954898	0.640805863873676	PROM2/SCARB2	2
GO:0000062	fatty-acyl-CoA binding	1/407	22/18367	0.389375166140035	0.640805863873676	ACBD4	1
GO:0005355	glucose transmembrane transporter activity	1/407	22/18367	0.389375166140035	0.640805863873676	SLC2A1	1
GO:0005416	amino acid:cation symporter activity	1/407	22/18367	0.389375166140035	0.640805863873676	SLC1A3	1
GO:0015106	bicarbonate transmembrane transporter activity	1/407	22/18367	0.389375166140035	0.640805863873676	SLC26A2	1
GO:0015149	hexose transmembrane transporter activity	1/407	22/18367	0.389375166140035	0.640805863873676	SLC2A1	1
GO:0016917	GABA receptor activity	1/407	22/18367	0.389375166140035	0.640805863873676	GABRE	1
GO:0070182	DNA polymerase binding	1/407	22/18367	0.389375166140035	0.640805863873676	PCNA	1
GO:0005126	cytokine receptor binding	7/407	271/18367	0.39450721705144	0.643693128757628	BAMBI/SPRED2/FERMT2/IRAK4/PRLR/IL6ST/SHC1	7
GO:0030246	carbohydrate binding	7/407	271/18367	0.39450721705144	0.643693128757628	P3H2/PLOD1/CLEC1A/MRC2/GALNT11/P3H1/CHID1	7
GO:0016922	nuclear receptor binding	4/407	144/18367	0.396082165585294	0.643693128757628	PPARG/TACC2/TRIM24/PCNA	4
GO:0061659	ubiquitin-like protein ligase activity	8/407	316/18367	0.401603063166129	0.643693128757628	RNF43/HACE1/TRIM24/RMND5B/TRIM27/MED31/DTX4/RNF19B	8
GO:0005158	insulin receptor binding	1/407	23/18367	0.402922416474241	0.643693128757628	SHC1	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	1/407	23/18367	0.402922416474241	0.643693128757628	PRKCH	1
GO:0016493	C-C chemokine receptor activity	1/407	23/18367	0.402922416474241	0.643693128757628	ACKR2	1
GO:0030552	cAMP binding	1/407	23/18367	0.402922416474241	0.643693128757628	RAPGEF2	1
GO:0050750	low-density lipoprotein particle receptor binding	1/407	23/18367	0.402922416474241	0.643693128757628	SYT1	1
GO:0070412	R-SMAD binding	1/407	23/18367	0.402922416474241	0.643693128757628	PPARG	1
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	1/407	23/18367	0.402922416474241	0.643693128757628	SPRTN	1
GO:1901567	fatty acid derivative binding	1/407	23/18367	0.402922416474241	0.643693128757628	ACBD4	1
GO:1990782	protein tyrosine kinase binding	3/407	105/18367	0.412232123377093	0.653696017897695	TJP2/PCNA/SHC1	3
GO:0004622	lysophospholipase activity	1/407	24/18367	0.416169831241739	0.653696017897695	ABHD12	1
GO:0010857	calcium-dependent protein kinase activity	1/407	24/18367	0.416169831241739	0.653696017897695	PRKCH	1
GO:0015145	monosaccharide transmembrane transporter activity	1/407	24/18367	0.416169831241739	0.653696017897695	SLC2A1	1
GO:0019789	SUMO transferase activity	1/407	24/18367	0.416169831241739	0.653696017897695	TRIM27	1
GO:0019957	C-C chemokine binding	1/407	24/18367	0.416169831241739	0.653696017897695	ACKR2	1
GO:0043495	protein-membrane adaptor activity	1/407	24/18367	0.416169831241739	0.653696017897695	EPB41L3	1
GO:0008173	RNA methyltransferase activity	2/407	65/18367	0.423953998072179	0.662915660466649	MRM1/NSUN4	2
GO:0019903	protein phosphatase binding	4/407	150/18367	0.426006067651368	0.662915660466649	MET/HMGCR/PTK2/EGFR	4
GO:0003887	DNA-directed DNA polymerase activity	1/407	25/18367	0.429124030592151	0.662915660466649	POLI	1
GO:0005227	calcium activated cation channel activity	1/407	25/18367	0.429124030592151	0.662915660466649	ANO6	1
GO:0034237	protein kinase A regulatory subunit binding	1/407	25/18367	0.429124030592151	0.662915660466649	WASF1	1
GO:0051019	mitogen-activated protein kinase binding	1/407	25/18367	0.429124030592151	0.662915660466649	ABL1	1
GO:0120227	acyl-CoA binding	1/407	25/18367	0.429124030592151	0.662915660466649	ACBD4	1
GO:0002039	p53 binding	2/407	66/18367	0.431576350038198	0.665135315941223	TRIM24/BLM	2
GO:0001637	G protein-coupled chemoattractant receptor activity	1/407	26/18367	0.441791488860006	0.666759044247244	ACKR2	1
GO:0004364	glutathione transferase activity	1/407	26/18367	0.441791488860006	0.666759044247244	GSTA4	1
GO:0004950	chemokine receptor activity	1/407	26/18367	0.441791488860006	0.666759044247244	ACKR2	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	1/407	26/18367	0.441791488860006	0.666759044247244	ZDHHC13	1
GO:0019707	protein-cysteine S-acyltransferase activity	1/407	26/18367	0.441791488860006	0.666759044247244	ZDHHC13	1
GO:0030371	translation repressor activity	1/407	26/18367	0.441791488860006	0.666759044247244	SHMT1	1
GO:0042974	retinoic acid receptor binding	1/407	26/18367	0.441791488860006	0.666759044247244	PPARG	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/407	26/18367	0.441791488860006	0.666759044247244	SLC26A2	1
GO:0097602	cullin family protein binding	1/407	26/18367	0.441791488860006	0.666759044247244	DCUN1D3	1
GO:0019843	rRNA binding	2/407	68/18367	0.446657671237431	0.670015635672264	RPF1/NSUN4	2
GO:0004521	endoribonuclease activity	2/407	69/18367	0.454114023093657	0.670015635672264	RCL1/ELAC2	2
GO:0004683	calmodulin-dependent protein kinase activity	1/407	27/18367	0.45417853776868	0.670015635672264	CAMK2G	1
GO:0004709	MAP kinase kinase kinase activity	1/407	27/18367	0.45417853776868	0.670015635672264	EGFR	1
GO:0008139	nuclear localization sequence binding	1/407	27/18367	0.45417853776868	0.670015635672264	NUP58	1
GO:0015215	nucleotide transmembrane transporter activity	1/407	27/18367	0.45417853776868	0.670015635672264	SLC25A4	1
GO:0016866	intramolecular transferase activity	1/407	27/18367	0.45417853776868	0.670015635672264	PMM1	1
GO:0048027	mRNA 5'-UTR binding	1/407	27/18367	0.45417853776868	0.670015635672264	SHMT1	1
GO:0051119	sugar transmembrane transporter activity	1/407	27/18367	0.45417853776868	0.670015635672264	SLC2A1	1
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	1/407	27/18367	0.45417853776868	0.670015635672264	TMEM30B	1
GO:0004860	protein kinase inhibitor activity	2/407	70/18367	0.461512564528336	0.679305010710247	SPRED2/TRIB1	2
GO:0017056	structural constituent of nuclear pore	1/407	28/18367	0.466291369564107	0.683268114238233	NUP58	1
GO:0051861	glycolipid binding	1/407	28/18367	0.466291369564107	0.683268114238233	CLN3	1
GO:0140030	modification-dependent protein binding	4/407	160/18367	0.474955785988839	0.691344605413407	PYGO1/TRIM24/WDR5/SPRTN	4
GO:0030276	clathrin binding	2/407	72/18367	0.476131881868698	0.691344605413407	SYT1/LRP1	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/407	29/18367	0.478136040079807	0.691344605413407	CDKL3	1
GO:0032452	histone demethylase activity	1/407	29/18367	0.478136040079807	0.691344605413407	KDM5B	1
GO:0097472	cyclin-dependent protein kinase activity	1/407	29/18367	0.478136040079807	0.691344605413407	CDKL3	1
GO:0140457	protein demethylase activity	1/407	29/18367	0.478136040079807	0.691344605413407	KDM5B	1
GO:0016746	acyltransferase activity	6/407	250/18367	0.479539158052079	0.691846142123594	AGPAT4/CPT1C/MBOAT7/ZDHHC13/LIPT2/LIPT1	6
GO:0033293	monocarboxylic acid binding	2/407	73/18367	0.483350680184548	0.692767386260129	PPARG/NR2F2	2
GO:0035064	methylated histone binding	2/407	73/18367	0.483350680184548	0.692767386260129	PYGO1/WDR5	2
GO:0140034	methylation-dependent protein binding	2/407	73/18367	0.483350680184548	0.692767386260129	PYGO1/WDR5	2
GO:0140098	catalytic activity, acting on RNA	9/407	386/18367	0.485869355421002	0.694856829259293	POLR1A/RCL1/TARS2/MRM1/HARS2/POLR3F/DDX3Y/ELAC2/NSUN4	9
GO:0005343	organic acid:sodium symporter activity	1/407	30/18367	0.489718471734705	0.69541677114266	SLC1A3	1
GO:0016417	S-acyltransferase activity	1/407	30/18367	0.489718471734705	0.69541677114266	ZDHHC13	1
GO:0022829	wide pore channel activity	1/407	30/18367	0.489718471734705	0.69541677114266	GJA1	1
GO:0019210	kinase inhibitor activity	2/407	74/18367	0.49050770727925	0.69541677114266	SPRED2/TRIB1	2
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	7/407	299/18367	0.49503106468428	0.699752918944003	ELK1/PPARG/TACC2/TRIM24/PCNA/CEBPA/BHLHE41	7
GO:0019003	GDP binding	2/407	75/18367	0.497602151407203	0.699752918944003	ARL3/RAB5B	2
GO:0000146	microfilament motor activity	1/407	31/18367	0.501044456465248	0.699752918944003	MYO1C	1
GO:0031210	phosphatidylcholine binding	1/407	31/18367	0.501044456465248	0.699752918944003	SCARB2	1
GO:0042910	xenobiotic transmembrane transporter activity	1/407	31/18367	0.501044456465248	0.699752918944003	SLC2A1	1
GO:0043015	gamma-tubulin binding	1/407	31/18367	0.501044456465248	0.699752918944003	RACGAP1	1
GO:0140318	protein transporter activity	1/407	31/18367	0.501044456465248	0.699752918944003	LRP2	1
GO:0001222	transcription corepressor binding	1/407	32/18367	0.512119658593228	0.710674526225772	EZH2	1
GO:0015605	organophosphate ester transmembrane transporter activity	1/407	32/18367	0.512119658593228	0.710674526225772	SLC25A4	1
GO:0051721	protein phosphatase 2A binding	1/407	32/18367	0.512119658593228	0.710674526225772	HMGCR	1
GO:0030971	receptor tyrosine kinase binding	2/407	78/18367	0.518502844439811	0.718011338494876	PCNA/SHC1	2
GO:0140101	catalytic activity, acting on a tRNA	3/407	124/18367	0.520629021329141	0.719434618081408	TARS2/HARS2/ELAC2	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	4/407	170/18367	0.522250691242881	0.719605041067493	P3H2/PLOD1/KDM5B/P3H1	4
GO:0005154	epidermal growth factor receptor binding	1/407	33/18367	0.522949617630728	0.719605041067493	SHC1	1
GO:0003713	transcription coactivator activity	6/407	262/18367	0.52507276136338	0.719869834097885	WWC1/ELK1/YAP1/TRIM24/ABL1/TRIM27	6
GO:0046332	SMAD binding	2/407	79/18367	0.525340123204258	0.719869834097885	PPARG/FERMT2	2
GO:0033218	amide binding	9/407	400/18367	0.528809519358677	0.722042431653793	FZD5/PPARG/CTSV/LRP1/ACBD4/NUP58/PPIL1/FKBP4/PRLR	9
GO:0015020	glucuronosyltransferase activity	1/407	34/18367	0.533539751023566	0.722042431653793	CHPF	1
GO:0016831	carboxy-lyase activity	1/407	34/18367	0.533539751023566	0.722042431653793	GGCX	1
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	1/407	34/18367	0.533539751023566	0.722042431653793	ELAC2	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/407	34/18367	0.533539751023566	0.722042431653793	SPRED2	1
GO:0045505	dynein intermediate chain binding	1/407	34/18367	0.533539751023566	0.722042431653793	DYNC1H1	1
GO:0042826	histone deacetylase binding	3/407	127/18367	0.536759048662263	0.724901395616046	GLI3/MAGEA10/BHLHE41	3
GO:0035591	signaling adaptor activity	2/407	81/18367	0.538817129375778	0.726183579714268	MPP7/SHC1	2
GO:0042887	amide transmembrane transporter activity	1/407	35/18367	0.543895356834585	0.731522502518795	GJA1	1
GO:0004519	endonuclease activity	3/407	129/18367	0.547339481306802	0.734646230032695	RCL1/TSN/ELAC2	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1/407	36/18367	0.554021616368096	0.737569428294924	MTHFD2L	1
GO:0034061	DNA polymerase activity	1/407	36/18367	0.554021616368096	0.737569428294924	POLI	1
GO:0042162	telomeric DNA binding	1/407	36/18367	0.554021616368096	0.737569428294924	BLM	1
GO:0043394	proteoglycan binding	1/407	36/18367	0.554021616368096	0.737569428294924	LRP1	1
GO:0001540	amyloid-beta binding	2/407	84/18367	0.558532755690826	0.742066845796128	FZD5/LRP1	2
GO:0030551	cyclic nucleotide binding	1/407	37/18367	0.563923596736771	0.746201931035525	RAPGEF2	1
GO:0071949	FAD binding	1/407	37/18367	0.563923596736771	0.746201931035525	ERO1B	1
GO:0042277	peptide binding	7/407	321/18367	0.570263231699501	0.75306938863543	FZD5/PPARG/CTSV/LRP1/NUP58/PPIL1/PRLR	7
GO:0005501	retinoid binding	1/407	38/18367	0.573606253372239	0.75444195975666	NR2F2	1
GO:0019840	isoprenoid binding	1/407	38/18367	0.573606253372239	0.75444195975666	NR2F2	1
GO:0005504	fatty acid binding	1/407	39/18367	0.583074432480619	0.760314855445579	PPARG	1
GO:0016776	phosphotransferase activity, phosphate group as acceptor	1/407	39/18367	0.583074432480619	0.760314855445579	TJP2	1
GO:0032451	demethylase activity	1/407	39/18367	0.583074432480619	0.760314855445579	KDM5B	1
GO:0050997	quaternary ammonium group binding	1/407	39/18367	0.583074432480619	0.760314855445579	SCARB2	1
GO:0051219	phosphoprotein binding	2/407	88/18367	0.583875377540651	0.760314855445579	ABL1/SHC1	2
GO:0043178	alcohol binding	2/407	89/18367	0.590041168282241	0.765242666875634	PROM2/SCARB2	2
GO:0015144	carbohydrate transmembrane transporter activity	1/407	40/18367	0.592332873444193	0.765242666875634	SLC2A1	1
GO:0017080	sodium channel regulator activity	1/407	40/18367	0.592332873444193	0.765242666875634	PRSS8	1
GO:0043014	alpha-tubulin binding	1/407	40/18367	0.592332873444193	0.765242666875634	RACGAP1	1
GO:0030331	estrogen receptor binding	1/407	41/18367	0.601386211170401	0.77388598883421	PCNA	1
GO:0048487	beta-tubulin binding	1/407	41/18367	0.601386211170401	0.77388598883421	RACGAP1	1
GO:0045182	translation regulator activity	3/407	140/18367	0.602911541863227	0.774327568471399	SHMT1/CYFIP1/MTRF1L	3
GO:0070851	growth factor receptor binding	3/407	141/18367	0.607735226711853	0.777639165068085	IRAK4/IL6ST/SHC1	3
GO:0001046	core promoter sequence-specific DNA binding	1/407	42/18367	0.610238978389306	0.777639165068085	EZH2	1
GO:0019205	nucleobase-containing compound kinase activity	1/407	42/18367	0.610238978389306	0.777639165068085	TJP2	1
GO:0019894	kinesin binding	1/407	42/18367	0.610238978389306	0.777639165068085	DCDC2	1
GO:0072341	modified amino acid binding	2/407	93/18367	0.614023265745443	0.78094221177333	SYT1/SCARB2	2
GO:0004180	carboxypeptidase activity	1/407	43/18367	0.61889560790066	0.783444596917979	BLMH	1
GO:0016790	thiolester hydrolase activity	1/407	43/18367	0.61889560790066	0.783444596917979	ABHD12	1
GO:0003924	GTPase activity	7/407	337/18367	0.621542509075261	0.783444596917979	ARL6/ARL15/RAB7B/RAC3/GNG10/ARL3/RAB5B	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3/407	144/18367	0.621971283049388	0.783444596917979	MANEA/PCNA/TDG	3
GO:0140375	immune receptor activity	3/407	144/18367	0.621971283049388	0.783444596917979	ACKR2/PRLR/IL6ST	3
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	1/407	44/18367	0.627360434771672	0.787205143247979	BCKDHB	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/407	44/18367	0.627360434771672	0.787205143247979	GABRE	1
GO:0005245	voltage-gated calcium channel activity	1/407	45/18367	0.635637698486562	0.791792591815145	ITGAV	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1/407	45/18367	0.635637698486562	0.791792591815145	ELAC2	1
GO:0048156	tau protein binding	1/407	45/18367	0.635637698486562	0.791792591815145	FKBP4	1
GO:0008528	G protein-coupled peptide receptor activity	3/407	147/18367	0.635851760755368	0.791792591815145	LGR5/ACKR2/SIGMAR1	3
GO:0001664	G protein-coupled receptor binding	6/407	295/18367	0.640585954179695	0.796174193525048	ITGB4/BAMBI/NPW/RNF43/WLS/RAPGEF2	6
GO:0019829	ATPase-coupled cation transmembrane transporter activity	1/407	47/18367	0.651646029038087	0.806477735905703	ATP7B	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	1/407	47/18367	0.651646029038087	0.806477735905703	GABRE	1
GO:0005496	steroid binding	2/407	100/18367	0.653381915692421	0.806477735905703	PROM2/SCARB2	2
GO:0005506	iron ion binding	3/407	151/18367	0.653801034757143	0.806477735905703	P3H2/PLOD1/P3H1	3
GO:0030295	protein kinase activator activity	2/407	101/18367	0.658736132431501	0.811037907410965	ERBB3/STK3	2
GO:0001653	peptide receptor activity	3/407	153/18367	0.662535386680452	0.813289275421408	LGR5/ACKR2/SIGMAR1	3
GO:0019887	protein kinase regulator activity	4/407	204/18367	0.665422134316231	0.813289275421408	SPRED2/TRIB1/ERBB3/STK3	4
GO:0043539	protein serine/threonine kinase activator activity	1/407	49/18367	0.666952682514672	0.813289275421408	STK3	1
GO:0098632	cell-cell adhesion mediator activity	1/407	49/18367	0.666952682514672	0.813289275421408	JAM3	1
GO:0005200	structural constituent of cytoskeleton	2/407	103/18367	0.669245788423274	0.813289275421408	EPB41L3/DMD	2
GO:0031490	chromatin DNA binding	2/407	103/18367	0.669245788423274	0.813289275421408	ZFX/EZH2	2
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	9/407	450/18367	0.669256365575785	0.813289275421408	ELK1/ELF3/NRF1/TFCP2L1/MEIS2/ZNF615/CEBPA/E4F1/NFIC	9
GO:0005048	signal sequence binding	1/407	50/18367	0.674352521919439	0.813504999898186	NUP58	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	1/407	50/18367	0.674352521919439	0.813504999898186	SLC25A4	1
GO:0030159	signaling receptor complex adaptor activity	1/407	50/18367	0.674352521919439	0.813504999898186	SHC1	1
GO:0004620	phospholipase activity	2/407	104/18367	0.674401854877428	0.813504999898186	PLBD1/ABHD12	2
GO:0022804	active transmembrane transporter activity	8/407	406/18367	0.680951529423365	0.815178419483665	SLC7A11/ATP7B/SLC1A3/SLC22A11/SLC26A2/SLC25A11/SLC16A1/SLC25A4	8
GO:0008227	G protein-coupled amine receptor activity	1/407	51/18367	0.681588342391066	0.815178419483665	ZNF219	1
GO:0016860	intramolecular oxidoreductase activity	1/407	51/18367	0.681588342391066	0.815178419483665	ERO1B	1
GO:0051018	protein kinase A binding	1/407	51/18367	0.681588342391066	0.815178419483665	WASF1	1
GO:0001216	DNA-binding transcription activator activity	9/407	456/18367	0.684356269666034	0.815178419483665	ELK1/ELF3/NRF1/TFCP2L1/MEIS2/ZNF615/CEBPA/E4F1/NFIC	9
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	6/407	310/18367	0.687177965781787	0.815178419483665	HIC2/PPARG/ZNF219/NFE2L3/E4F1/BHLHE41	6
GO:0004518	nuclease activity	4/407	210/18367	0.687408657185417	0.815178419483665	RCL1/TSN/AEN/ELAC2	4
GO:0017046	peptide hormone binding	1/407	52/18367	0.688663770685827	0.815178419483665	PRLR	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/407	52/18367	0.688663770685827	0.815178419483665	SPRTN	1
GO:0019209	kinase activator activity	2/407	107/18367	0.689479151746489	0.815178419483665	ERBB3/STK3	2
GO:0051087	chaperone binding	2/407	107/18367	0.689479151746489	0.815178419483665	LRP2/SCARB2	2
GO:0090079	translation regulator activity, nucleic acid binding	2/407	108/18367	0.694375864413718	0.815534594610739	SHMT1/MTRF1L	2
GO:0050661	NADP binding	1/407	53/18367	0.695582353559475	0.815534594610739	HMGCR	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	1/407	53/18367	0.695582353559475	0.815534594610739	SLC25A4	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/407	53/18367	0.695582353559475	0.815534594610739	SLC16A1	1
GO:0001217	DNA-binding transcription repressor activity	6/407	313/18367	0.69600586013344	0.815534594610739	HIC2/PPARG/ZNF219/NFE2L3/E4F1/BHLHE41	6
GO:0005096	GTPase activator activity	9/407	462/18367	0.699030057167791	0.816366678543456	RUNDC1/RGPD5/SRGAP3/MYO9A/NRP1/DOCK5/RACGAP1/PLXNB1/RAPGEF2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2/407	109/18367	0.699208712462411	0.816366678543456	ATP7B/SLC26A2	2
GO:0005544	calcium-dependent phospholipid binding	1/407	54/18367	0.702347559527657	0.818363242810797	SYT1	1
GO:0008047	enzyme activator activity	2/407	110/18367	0.703978113976537	0.818363242810797	MMP15/WRNIP1	2
GO:0044389	ubiquitin-like protein ligase binding	6/407	316/18367	0.704666975488992	0.818363242810797	FZD5/HGS/TRIB1/ERBB3/CUL2/EGFR	6
GO:0030374	nuclear receptor coactivator activity	1/407	56/18367	0.715431333902493	0.829393847267492	ELK1	1
GO:0035091	phosphatidylinositol binding	5/407	271/18367	0.720621170497961	0.833775103277288	ZFYVE9/SYT1/HGS/FERMT2/RACGAP1	5
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1/407	57/18367	0.721756463447668	0.833775103277288	AIFM2	1
GO:0016887	ATP hydrolysis activity	5/407	272/18367	0.72359616283485	0.834428673691597	ATP7B/WRNIP1/BLM/DDX3Y/MCM5	5
GO:0004540	ribonuclease activity	2/407	116/18367	0.731287082138639	0.841815533920577	RCL1/ELAC2	2
GO:0005525	GTP binding	7/407	377/18367	0.73357316230756	0.84196644726778	ARL6/ARL15/RAB7B/RAC3/SEPHS1/ARL3/RAB5B	7
GO:0098631	cell adhesion mediator activity	1/407	59/18367	0.733989070824278	0.84196644726778	JAM3	1
GO:0046982	protein heterodimerization activity	6/407	328/18367	0.737629828541519	0.844224515530295	SYT1/JAM3/TENM3/ERBB3/BHLHE41/XBP1	6
GO:0022824	transmitter-gated ion channel activity	1/407	60/18367	0.739902684991556	0.844224515530295	GABRE	1
GO:0022835	transmitter-gated channel activity	1/407	60/18367	0.739902684991556	0.844224515530295	GABRE	1
GO:1901981	phosphatidylinositol phosphate binding	3/407	173/18367	0.741113124320488	0.844224515530295	SYT1/FERMT2/RACGAP1	3
GO:0098960	postsynaptic neurotransmitter receptor activity	1/407	62/18367	0.75133937068155	0.852906911258952	GABRE	1
GO:1990841	promoter-specific chromatin binding	1/407	62/18367	0.75133937068155	0.852906911258952	EZH2	1
GO:0051082	unfolded protein binding	2/407	122/18367	0.756429635819664	0.855481382199942	UGGT2/ERO1B	2
GO:0030695	GTPase regulator activity	9/407	488/18367	0.757525498741933	0.855481382199942	RUNDC1/RGPD5/SRGAP3/MYO9A/NRP1/DOCK5/RACGAP1/PLXNB1/RAPGEF2	9
GO:0060589	nucleoside-triphosphatase regulator activity	9/407	488/18367	0.757525498741933	0.855481382199942	RUNDC1/RGPD5/SRGAP3/MYO9A/NRP1/DOCK5/RACGAP1/PLXNB1/RAPGEF2	9
GO:0019207	kinase regulator activity	4/407	233/18367	0.762110835020403	0.859178307983415	SPRED2/TRIB1/ERBB3/STK3	4
GO:0004866	endopeptidase inhibitor activity	3/407	180/18367	0.76494375515961	0.860890308641829	SERPINE2/ITIH5/SPINT1	3
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2/407	125/18367	0.768223035853112	0.863097921927596	BTD/MTHFD2L	2
GO:0009055	electron transfer activity	2/407	126/18367	0.77204249619771	0.865903827071062	AIFM2/GLDC	2
GO:0097110	scaffold protein binding	1/407	67/18367	0.777783918533323	0.870852079725344	IL6ST	1
GO:0019001	guanyl nucleotide binding	7/407	398/18367	0.782291201944061	0.870931519981857	ARL6/ARL15/RAB7B/RAC3/SEPHS1/ARL3/RAB5B	7
GO:0032561	guanyl ribonucleotide binding	7/407	398/18367	0.782291201944061	0.870931519981857	ARL6/ARL15/RAB7B/RAC3/SEPHS1/ARL3/RAB5B	7
GO:0016298	lipase activity	2/407	129/18367	0.783173534762311	0.870931519981857	PLBD1/ABHD12	2
GO:0031072	heat shock protein binding	2/407	129/18367	0.783173534762311	0.870931519981857	METTL21C/FKBP4	2
GO:0030414	peptidase inhibitor activity	3/407	187/18367	0.786964297808072	0.873663754346249	SERPINE2/ITIH5/SPINT1	3
GO:0031625	ubiquitin protein ligase binding	5/407	297/18367	0.790674263348736	0.876297195420341	FZD5/TRIB1/ERBB3/CUL2/EGFR	5
GO:0042393	histone binding	4/407	244/18367	0.792591972319113	0.876938753157126	PYGO1/KDM5B/TRIM24/WDR5	4
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/407	71/18367	0.796904390707726	0.877669019955335	BTD	1
GO:0031491	nucleosome binding	1/407	71/18367	0.796904390707726	0.877669019955335	SMARCA1	1
GO:0044325	transmembrane transporter binding	2/407	133/18367	0.797271857822022	0.877669019955335	CHERP/TCAF1	2
GO:0005230	extracellular ligand-gated ion channel activity	1/407	73/18367	0.805839974939415	0.882650808671098	GABRE	1
GO:0015370	solute:sodium symporter activity	1/407	73/18367	0.805839974939415	0.882650808671098	SLC1A3	1
GO:0140104	molecular carrier activity	1/407	73/18367	0.805839974939415	0.882650808671098	EMC1	1
GO:0061135	endopeptidase regulator activity	3/407	194/18367	0.807251132122565	0.882720353155727	SERPINE2/ITIH5/SPINT1	3
GO:0003725	double-stranded RNA binding	1/407	74/18367	0.810159595044349	0.882952636861977	TFRC	1
GO:0017022	myosin binding	1/407	74/18367	0.810159595044349	0.882952636861977	DMD	1
GO:0003724	RNA helicase activity	1/407	77/18367	0.822551673916543	0.894969013978963	DDX3Y	1
GO:0001221	transcription coregulator binding	1/407	78/18367	0.826500360013644	0.897774022900393	EZH2	1
GO:0008186	ATP-dependent activity, acting on RNA	1/407	79/18367	0.830361388690687	0.898986296846943	DDX3Y	1
GO:0034987	immunoglobulin receptor binding	1/407	79/18367	0.830361388690687	0.898986296846943	IGLL1	1
GO:0015293	symporter activity	2/407	144/18367	0.831940932715152	0.899210084040304	SLC1A3/SLC16A1	2
GO:0004527	exonuclease activity	1/407	80/18367	0.834136701179909	0.900098087764152	AEN	1
GO:0015267	channel activity	8/407	480/18367	0.838232389889379	0.902032262717282	GABRE/TMC5/ANO2/GJA1/CLDN4/TMEM175/ITGAV/ANO6	8
GO:0022803	passive transmembrane transporter activity	8/407	481/18367	0.83984981967011	0.902032262717282	GABRE/TMC5/ANO2/GJA1/CLDN4/TMEM175/ITGAV/ANO6	8
GO:0052689	carboxylic ester hydrolase activity	2/407	147/18367	0.840422633332983	0.902032262717282	TARS2/ABHD12	2
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	1/407	82/18367	0.841437729038564	0.902032262717282	SYT1	1
GO:0005216	ion channel activity	7/407	432/18367	0.846642673466765	0.905175082428586	GABRE/TMC5/ANO2/CLDN4/TMEM175/ITGAV/ANO6	7
GO:0008135	translation factor activity, RNA binding	1/407	84/18367	0.848418132593583	0.905175082428586	MTRF1L	1
GO:0140677	molecular function activator activity	2/407	150/18367	0.848515268108629	0.905175082428586	MMP15/WRNIP1	2
GO:0016209	antioxidant activity	1/407	86/18367	0.855091958889848	0.910707696053415	TXNRD3	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	1/407	88/18367	0.861472641002516	0.914838277317095	AIFM2	1
GO:0016791	phosphatase activity	4/407	275/18367	0.86187336873136	0.914838277317095	SYNJ2/PPP4R1/INPP4A/CAMK2G	4
GO:0019888	protein phosphatase regulator activity	1/407	89/18367	0.864557089556155	0.914838277317095	PPP4R1	1
GO:0051117	ATPase binding	1/407	89/18367	0.864557089556155	0.914838277317095	EGFR	1
GO:0022836	gated channel activity	5/407	340/18367	0.875575445805393	0.925003091939568	GABRE/TMC5/ANO2/ITGAV/ANO6	5
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	1/407	94/18367	0.87898149755353	0.927106088401871	MANEA	1
GO:0061134	peptidase regulator activity	3/407	230/18367	0.887521970875713	0.934609149394843	SERPINE2/ITIH5/SPINT1	3
GO:0004722	protein serine/threonine phosphatase activity	1/407	98/18367	0.889409345798013	0.935093292933705	CAMK2G	1
GO:0004721	phosphoprotein phosphatase activity	2/407	174/18367	0.900942039403274	0.94570037789927	PPP4R1/CAMK2G	2
GO:0015294	solute:cation symporter activity	1/407	104/18367	0.903394432542099	0.94675736530412	SLC1A3	1
GO:0019208	phosphatase regulator activity	1/407	107/18367	0.909710613085384	0.950335648438479	PPP4R1	1
GO:1902936	phosphatidylinositol bisphosphate binding	1/407	107/18367	0.909710613085384	0.950335648438479	SYT1	1
GO:0015399	primary active transmembrane transporter activity	2/407	181/18367	0.912707311629611	0.951947912607317	ATP7B/SLC26A2	2
GO:0047485	protein N-terminus binding	1/407	110/18367	0.915614782782056	0.952642105340841	SUV39H1	1
GO:0030594	neurotransmitter receptor activity	1/407	111/18367	0.917495967172028	0.952642105340841	GABRE	1
GO:0046873	metal ion transmembrane transporter activity	6/407	430/18367	0.917736135068811	0.952642105340841	ATP7B/SLC1A3/ZDHHC13/TMEM175/ITGAV/SLC39A1	6
GO:0005262	calcium channel activity	1/407	119/18367	0.931114774488034	0.965000280521617	ITGAV	1
GO:0005267	potassium channel activity	1/407	121/18367	0.934153395687932	0.966620022394306	TMEM175	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/407	124/18367	0.938462441866198	0.967573112134399	HMGCR	1
GO:0005244	voltage-gated ion channel activity	2/407	201/18367	0.93950610582821	0.967573112134399	ITGAV/ANO6	2
GO:0022832	voltage-gated channel activity	2/407	201/18367	0.93950610582821	0.967573112134399	ITGAV/ANO6	2
GO:0140678	molecular function inhibitor activity	1/407	128/18367	0.943773400163927	0.970442036275309	ID4	1
GO:0015078	proton transmembrane transporter activity	1/407	130/18367	0.946254842218735	0.971468529237103	SLC25A4	1
GO:0015085	calcium ion transmembrane transporter activity	1/407	135/18367	0.951990892687707	0.973926359480976	ITGAV	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	1/407	136/18367	0.953062618591398	0.973926359480976	HMGCR	1
GO:0099106	ion channel regulator activity	1/407	139/18367	0.956136703013538	0.973926359480976	PRSS8	1
GO:0005085	guanyl-nucleotide exchange factor activity	2/407	223/18367	0.959919249654539	0.973926359480976	DOCK5/RAPGEF2	2
GO:0015276	ligand-gated ion channel activity	1/407	143/18367	0.959925306611723	0.973926359480976	GABRE	1
GO:0022834	ligand-gated channel activity	1/407	143/18367	0.959925306611723	0.973926359480976	GABRE	1
GO:0022843	voltage-gated cation channel activity	1/407	143/18367	0.959925306611723	0.973926359480976	ITGAV	1
GO:0016247	channel regulator activity	1/407	145/18367	0.961695357767099	0.973926359480976	PRSS8	1
GO:0042578	phosphoric ester hydrolase activity	4/407	366/18367	0.963505565518187	0.973926359480976	SYNJ2/PPP4R1/INPP4A/CAMK2G	4
GO:0043021	ribonucleoprotein complex binding	1/407	149/18367	0.965004896646036	0.973926359480976	EZH2	1
GO:0046906	tetrapyrrole binding	1/407	149/18367	0.965004896646036	0.973926359480976	MMAB	1
GO:0015081	sodium ion transmembrane transporter activity	1/407	152/18367	0.967298440524484	0.974739197759288	SLC1A3	1
GO:0015079	potassium ion transmembrane transporter activity	1/407	155/18367	0.969442012904654	0.975398645856449	TMEM175	1
GO:0003823	antigen binding	1/407	171/18367	0.97871818443485	0.983221488964458	IGLL1	1
GO:0005261	cation channel activity	3/407	335/18367	0.980284409535001	0.983286812014434	TMEM175/ITGAV/ANO6	3
GO:0048018	receptor ligand activity	2/407	487/18367	0.999806168669267	0.999836281388961	SEMA4G/SEMA6A	2
GO:0030546	signaling receptor activator activity	2/407	495/18367	0.999836281388961	0.999836281388961	SEMA4G/SEMA6A	2