ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	geneID	Count
GO:0019838	growth factor binding	14/274	141/18367	2.58766145723424e-08	1.30446496609767e-05	LRP2/ITGB4/EGFR/GPC1/CRIM1/ITGA6/IGF1R/FLT1/LIFR/COL4A1/ERBB3/TGFBR3/ITGAV/LTBP1	14
GO:0005201	extracellular matrix structural constituent	15/274	172/18367	4.72632234093359e-08	1.30446496609767e-05	FBN2/FBN1/COL14A1/FBLN1/LAMC1/EFEMP1/VWA1/LAMA5/FRAS1/TINAGL1/COL4A2/COL21A1/LAMB1/COL4A1/LTBP1	15
GO:0050840	extracellular matrix binding	9/274	56/18367	1.31723714139912e-07	2.42371634017438e-05	ADGRG1/DAG1/GPC1/ITGA6/BCAM/TINAGL1/ITGB1/SMOC1/ITGAV	9
GO:0008201	heparin binding	14/274	166/18367	2.02326038796528e-07	2.79209933539209e-05	FBN1/CCDC80/ADGRG1/ADAMTS1/APP/FSTL1/BMP7/PTPRF/LRPAP1/SOD3/PCOLCE2/APLP2/SMOC1/TGFBR3	14
GO:0031994	insulin-like growth factor I binding	5/274	13/18367	8.31397677983809e-07	9.17863036494125e-05	LRP2/ITGB4/ITGA6/IGF1R/ITGAV	5
GO:0008509	anion transmembrane transporter activity	18/274	314/18367	1.23783977333835e-06	0.000113881259147128	SLC26A2/GABRE/SLC22A11/GJA1/CLDN4/SLC13A4/SLC19A1/SLC16A12/FXYD3/SLC2A1/SLC6A4/SLC25A1/SLC25A4/SLC5A6/SLC38A1/SLC38A9/SLC52A1/SLC52A3	18
GO:0001618	virus receptor activity	9/274	76/18367	1.90963558246876e-06	0.000130913845736821	EGFR/DAG1/DPP4/ITGB1/CD46/CD55/BSG/ITGAV/SLC52A1	9
GO:0005539	glycosaminoglycan binding	15/274	230/18367	2.00905329624973e-06	0.000130913845736821	FBN1/CCDC80/ADGRG1/ADAMTS1/APP/FSTL1/EXTL2/BMP7/PTPRF/LRPAP1/SOD3/PCOLCE2/APLP2/SMOC1/TGFBR3	15
GO:0140272	exogenous protein binding	9/274	77/18367	2.13446487614382e-06	0.000130913845736821	EGFR/DAG1/DPP4/ITGB1/CD46/CD55/BSG/ITGAV/SLC52A1	9
GO:0043236	laminin binding	6/274	28/18367	2.98349540110352e-06	0.000164688946140914	DAG1/GPC1/ITGA6/BCAM/TINAGL1/ITGB1	6
GO:0005520	insulin-like growth factor binding	6/274	29/18367	3.71496629982053e-06	0.000186423763409176	LRP2/ITGB4/CRIM1/ITGA6/IGF1R/ITGAV	6
GO:0008514	organic anion transmembrane transporter activity	13/274	185/18367	4.31872344266476e-06	0.000198661278362579	SLC26A2/SLC22A11/GJA1/SLC19A1/SLC16A12/SLC2A1/SLC25A1/SLC25A4/SLC5A6/SLC38A1/SLC38A9/SLC52A1/SLC52A3	13
GO:0090482	vitamin transmembrane transporter activity	6/274	31/18367	5.61576716880002e-06	0.000238454113629047	SLC19A3/SLC19A1/SLC2A1/SLC5A6/SLC52A1/SLC52A3	6
GO:0005178	integrin binding	11/274	144/18367	1.08033258652602e-05	0.000425959705544543	FBN1/ITGB4/EGFR/FBLN1/PLPP3/P4HB/JAM3/LAMA5/ITGB1/LAMB1/ITGAV	11
GO:1901681	sulfur compound binding	14/274	265/18367	4.71158304572497e-05	0.00173386256082679	FBN1/CCDC80/ADGRG1/ADAMTS1/APP/FSTL1/BMP7/PTPRF/LRPAP1/SOD3/PCOLCE2/APLP2/SMOC1/TGFBR3	14
GO:0001968	fibronectin binding	5/274	28/18367	5.2851319979437e-05	0.00182337053929058	CCDC80/FBLN1/CTSL/ITGB1/ITGAV	5
GO:0019199	transmembrane receptor protein kinase activity	10/274	143/18367	5.79793648529482e-05	0.00188262408228397	EGFR/MET/EPHB4/CRIM1/EFEMP1/IGF1R/FLT1/ERBB3/TGFBR3/LTBP1	10
GO:0098631	cell adhesion mediator activity	6/274	59/18367	0.000242326618521976	0.00743134963467392	JAM3/BCAM/DSP/ITGB1/DSG2/BSG	6
GO:0008013	beta-catenin binding	7/274	85/18367	0.000278823209775399	0.0079145779132874	CDH1/KANK1/TBL1X/GJA1/CBY1/DACT2/DLG5	7
GO:0072349	modified amino acid transmembrane transporter activity	4/274	22/18367	0.000286760069322007	0.0079145779132874	GJA1/SLC19A1/SLC16A12/SLC5A6	4
GO:0097493	structural molecule activity conferring elasticity	3/274	11/18367	0.000495850168261338	0.0130337758514409	FBN2/FBN1/LAMC1	3
GO:0004714	transmembrane receptor protein tyrosine kinase activity	8/274	124/18367	0.000548506276783159	0.0136664029029208	EGFR/MET/EPHB4/CRIM1/EFEMP1/IGF1R/FLT1/ERBB3	8
GO:0005518	collagen binding	6/274	69/18367	0.000569433454288368	0.0136664029029208	COL14A1/ADGRG1/CTSL/ITGB1/PCOLCE2/SERPINH1	6
GO:0004867	serine-type endopeptidase inhibitor activity	7/274	98/18367	0.000663310674864906	0.0152561455218928	ITIH5/SPINT1/APP/CRIM1/SPINT2/APLP2/SERPINH1	7
GO:0004713	protein tyrosine kinase activity	8/274	136/18367	0.00100627538157903	0.022169929127352	EGFR/MET/EPHB4/CRIM1/EFEMP1/IGF1R/FLT1/ERBB3	8
GO:1901682	sulfur compound transmembrane transporter activity	5/274	52/18367	0.00104423579223035	0.022169929127352	SLC26A2/SLC19A3/GJA1/SLC13A4/SLC5A6	5
GO:0003779	actin binding	15/274	440/18367	0.00262650768633041	0.0536974904760884	EGFR/SYNE2/DAG1/MYH10/P4HB/PFN2/RAI14/SVIL/SLC6A4/ITGB1/HOOK1/CALD1/TRIOBP/COBL/ADD3	15
GO:0046943	carboxylic acid transmembrane transporter activity	8/274	163/18367	0.00315023612545172	0.0594393362191656	SLC26A2/SLC27A2/SLC19A1/SLC16A12/SLC25A1/SLC5A6/SLC38A1/SLC38A9	8
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/274	41/18367	0.00317975185489454	0.0594393362191656	COL14A1/COL4A2/COL21A1/COL4A1	4
GO:0005342	organic acid transmembrane transporter activity	8/274	164/18367	0.00327010777586879	0.0594393362191656	SLC26A2/SLC27A2/SLC19A1/SLC16A12/SLC25A1/SLC5A6/SLC38A1/SLC38A9	8
GO:0015291	secondary active transmembrane transporter activity	10/274	240/18367	0.00333807866448212	0.0594393362191656	SLC26A2/SLC22A11/SLC13A4/SLC19A1/SLC16A12/SLC6A4/SLC25A1/SLC25A4/SLC5A6/SLC38A1	10
GO:0045296	cadherin binding	12/274	332/18367	0.00433347722436559	0.0747524821203065	EGFR/CDH1/ITGA6/PPFIBP1/DLG1/ITGB1/FNBP1L/CD46/CALD1/CTNND1/BSG/MPP7	12
GO:0017134	fibroblast growth factor binding	3/274	23/18367	0.00466280108922766	0.0758774333085829	GPC1/TGFBR3/ITGAV	3
GO:0004721	phosphoprotein phosphatase activity	8/274	174/18367	0.00467361002263011	0.0758774333085829	PTPRF/DLG1/CAMK2G/DUSP9/PDP2/CTDSPL/PTPN14/PHLPP1	8
GO:0050431	transforming growth factor beta binding	3/274	24/18367	0.00527078730763707	0.0831278455375903	TGFBR3/ITGAV/LTBP1	3
GO:0015026	coreceptor activity	4/274	48/18367	0.00563288625861411	0.086370922632083	LRP5/ITGB1/TGFBR3/ITGAV	4
GO:0098632	cell-cell adhesion mediator activity	4/274	49/18367	0.00606296580370159	0.0904528952336021	JAM3/DSP/DSG2/BSG	4
GO:0003712	transcription coregulator activity	15/274	489/18367	0.00688563956651951	0.0992379402597366	TBL1X/MAGED1/BRD4/PRMT5/RBPMS/TAF11/SIN3B/PTPN14/RBFOX2/EID2/YAF2/WWTR1/SMARCA2/CBX4/DCAF6	15
GO:0003714	transcription corepressor activity	8/274	187/18367	0.00714040343489775	0.0992379402597366	TBL1X/PRMT5/SIN3B/RBFOX2/EID2/YAF2/WWTR1/CBX4	8
GO:0004709	MAP kinase kinase kinase activity	3/274	27/18367	0.00737093396856739	0.0992379402597366	EGFR/MAP3K4/MAP3K13	3
GO:0045499	chemorepellent activity	3/274	27/18367	0.00737093396856739	0.0992379402597366	SEMA6A/DPP4/SEMA6D	3
GO:0061134	peptidase regulator activity	9/274	230/18367	0.00782452239212637	0.101206365474519	ITIH5/FBLN1/SPINT1/APP/CRIM1/PCOLCE2/SPINT2/APLP2/SERPINH1	9
GO:0015103	inorganic anion transmembrane transporter activity	7/274	152/18367	0.00788382919457303	0.101206365474519	SLC26A2/GABRE/SLC22A11/CLDN4/SLC13A4/FXYD3/SLC6A4	7
GO:0030165	PDZ domain binding	5/274	84/18367	0.00844276400955171	0.104412763386869	CRIM1/GJA1/ADRB1/CADM1/TGFBR3	5
GO:0016791	phosphatase activity	10/274	275/18367	0.00851191005871219	0.104412763386869	PLPP3/PTPRF/DLG1/CAMK2G/DUSP9/PDP2/EPHX2/CTDSPL/PTPN14/PHLPP1	10
GO:0015301	anion:anion antiporter activity	3/274	29/18367	0.00900888728449753	0.10810664741397	SLC26A2/SLC19A1/SLC25A4	3
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	2/274	11/18367	0.011159040118165	0.131059364792065	DSP/DSG2	2
GO:0140323	solute:anion antiporter activity	3/274	33/18367	0.0128775391898065	0.14639124551379	SLC26A2/SLC19A1/SLC25A4	3
GO:0005024	transforming growth factor beta-activated receptor activity	2/274	12/18367	0.013260076586394	0.14639124551379	TGFBR3/LTBP1	2
GO:0045295	gamma-catenin binding	2/274	12/18367	0.013260076586394	0.14639124551379	CDH1/DSC3	2
GO:0008376	acetylgalactosaminyltransferase activity	3/274	34/18367	0.0139708651808867	0.151214070193126	EXTL2/CHPF/GALNT11	3
GO:0042887	amide transmembrane transporter activity	3/274	35/18367	0.0151153523040564	0.157759630602173	GJA1/SLC19A1/SLC5A6	3
GO:0005542	folic acid binding	2/274	13/18367	0.0155181509751403	0.157759630602173	SLC19A1/FOLR1	2
GO:0008271	secondary active sulfate transmembrane transporter activity	2/274	13/18367	0.0155181509751403	0.157759630602173	SLC26A2/SLC13A4	2
GO:0004722	protein serine/threonine phosphatase activity	5/274	98/18367	0.0157188037737672	0.157759630602173	CAMK2G/DUSP9/PDP2/CTDSPL/PHLPP1	5
GO:0015373	anion:sodium symporter activity	2/274	14/18367	0.0179281456823115	0.171893460126462	SLC13A4/SLC6A4	2
GO:0015926	glucosidase activity	2/274	14/18367	0.0179281456823115	0.171893460126462	AGL/GANAB	2
GO:0019955	cytokine binding	6/274	139/18367	0.0180612693611137	0.171893460126462	CSF3R/ITGB1/LIFR/TGFBR3/ITGAV/LTBP1	6
GO:0004866	endopeptidase inhibitor activity	7/274	180/18367	0.0186036837804463	0.174054804183158	ITIH5/SPINT1/APP/CRIM1/SPINT2/APLP2/SERPINH1	7
GO:0022853	active ion transmembrane transporter activity	9/274	267/18367	0.0191596150749546	0.176268458689582	SLC26A2/SLC22A11/SLC13A4/SLC19A1/SLC6A4/SLC25A1/SLC25A4/SLC5A6/SLC38A1	9
GO:0004177	aminopeptidase activity	3/274	40/18367	0.0216125524629266	0.195575884582549	DPP4/ENPEP/MMP15	3
GO:0030414	peptidase inhibitor activity	7/274	187/18367	0.0223882430794121	0.199327583545734	ITIH5/SPINT1/APP/CRIM1/SPINT2/APLP2/SERPINH1	7
GO:0032183	SUMO binding	2/274	16/18367	0.0231840071629723	0.199962061780636	TDG/CBX4	2
GO:0042577	lipid phosphatase activity	2/274	16/18367	0.0231840071629723	0.199962061780636	PLPP3/EPHX2	2
GO:0015370	solute:sodium symporter activity	4/274	73/18367	0.0236325592649811	0.200694964834916	SLC13A4/SLC6A4/SLC5A6/SLC38A1	4
GO:0004222	metalloendopeptidase activity	5/274	111/18367	0.0254309559204012	0.203184050060767	ADAMTS6/ADAMTS1/MME/ADAMTS19/MMP15	5
GO:0005324	long-chain fatty acid transporter activity	2/274	17/18367	0.0260202133222971	0.203184050060767	SLC27A2/SLC2A1	2
GO:0015095	magnesium ion transmembrane transporter activity	2/274	17/18367	0.0260202133222971	0.203184050060767	CNNM2/TUSC3	2
GO:0015116	sulfate transmembrane transporter activity	2/274	17/18367	0.0260202133222971	0.203184050060767	SLC26A2/SLC13A4	2
GO:0048531	beta-1,3-galactosyltransferase activity	2/274	17/18367	0.0260202133222971	0.203184050060767	B3GNT3/C1GALT1	2
GO:0016504	peptidase activator activity	3/274	43/18367	0.026134180352019	0.203184050060767	FBLN1/APP/PCOLCE2	3
GO:0061135	endopeptidase regulator activity	7/274	194/18367	0.026675332110284	0.204510879512177	ITIH5/SPINT1/APP/CRIM1/SPINT2/APLP2/SERPINH1	7
GO:0016758	hexosyltransferase activity	7/274	197/18367	0.0286730618171132	0.21335914341971	EXTL2/CHPF/AGL/GALNT11/B3GNT3/TMTC3/C1GALT1	7
GO:0000295	adenine nucleotide transmembrane transporter activity	2/274	18/18367	0.0289890140515911	0.21335914341971	SLC19A1/SLC25A4	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	2/274	18/18367	0.0289890140515911	0.21335914341971	SLC19A1/SLC25A4	2
GO:0004674	protein serine/threonine kinase activity	11/274	386/18367	0.0307949208070543	0.223668372177552	EGFR/MAST4/BRD4/CAMK2G/MAP3K4/CDKL5/MAP3K13/PRKDC/PDPK1/TGFBR3/LTBP1	11
GO:0005516	calmodulin binding	7/274	201/18367	0.0314910482106774	0.225754007951869	EGFR/MYH10/CAMK2G/SYT7/KCNN4/CALD1/ADD3	7
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	2/274	19/18367	0.0320858527769007	0.227069111959605	TGFBR3/LTBP1	2
GO:0016500	protein-hormone receptor activity	2/274	20/18367	0.0353062784944335	0.243613321611591	LGR5/IGF1R	2
GO:0031683	G-protein beta/gamma-subunit complex binding	2/274	20/18367	0.0353062784944335	0.243613321611591	GNA12/GNA11	2
GO:0005243	gap junction channel activity	2/274	21/18367	0.0386459436537687	0.260153181669272	GJA1/GJA5	2
GO:0015216	purine nucleotide transmembrane transporter activity	2/274	21/18367	0.0386459436537687	0.260153181669272	SLC19A1/SLC25A4	2
GO:0004602	glutathione peroxidase activity	2/274	22/18367	0.0421006020803638	0.273406262921892	GPX8/MGST3	2
GO:0005537	mannose binding	2/274	22/18367	0.0421006020803638	0.273406262921892	LMAN1/BSG	2
GO:0015296	anion:cation symporter activity	2/274	22/18367	0.0421006020803638	0.273406262921892	SLC13A4/SLC6A4	2
GO:0003713	transcription coactivator activity	8/274	262/18367	0.0433747283560483	0.278405233169054	MAGED1/BRD4/RBPMS/TAF11/YAF2/WWTR1/SMARCA2/DCAF6	8
GO:0051015	actin filament binding	7/274	217/18367	0.0446016526750369	0.280085455878196	EGFR/SYNE2/MYH10/SVIL/SLC6A4/TRIOBP/ADD3	7
GO:0005158	insulin receptor binding	2/274	23/18367	0.0456661069366624	0.280085455878196	IGF1R/PDPK1	2
GO:0030215	semaphorin receptor binding	2/274	23/18367	0.0456661069366624	0.280085455878196	SEMA6A/SEMA6D	2
GO:0140103	catalytic activity, acting on a glycoprotein	2/274	23/18367	0.0456661069366624	0.280085455878196	B3GNT3/C1GALT1	2
GO:0042578	phosphoric ester hydrolase activity	10/274	366/18367	0.0486146284764915	0.293003458965234	PLPP3/PTPRF/DLG1/CAMK2G/DUSP9/PDP2/EPHX2/CTDSPL/PTPN14/PHLPP1	10
GO:0005080	protein kinase C binding	3/274	55/18367	0.0488339098275389	0.293003458965234	DACT2/DSP/ITGAV	3
GO:0072341	modified amino acid binding	4/274	93/18367	0.0505110360494807	0.299633603388271	MME/SLC19A1/FOLR1/SYT7	4
GO:0030246	carbohydrate binding	8/274	271/18367	0.0510245628958287	0.299633603388271	AGL/GALNT11/MLEC/PLOD2/GANAB/LMAN1/BSG/MAN2A1	8
GO:0043177	organic acid binding	5/274	135/18367	0.0518886686276967	0.301500474552511	SLC19A1/FOLR1/NR2F2/PLOD2/GLDC	5
GO:0008327	methyl-CpG binding	2/274	25/18367	0.053113553304472	0.305402931500714	DNMT1/PRMT5	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	3/274	58/18367	0.0556240869908532	0.316541196071659	SLC27A2/SLC16A12/SLC5A6	3
GO:0004175	endopeptidase activity	11/274	430/18367	0.0585273590571569	0.32966430815868	ADAMTS6/ADAMTS1/MME/ADAMTS19/DPP4/CTSL/SPPL2B/MMP15/PRSS8/MBTPS1/IMMP2L	11
GO:0015215	nucleotide transmembrane transporter activity	2/274	27/18367	0.0609570196853227	0.329885047708805	SLC19A1/SLC25A4	2
GO:0016405	CoA-ligase activity	2/274	27/18367	0.0609570196853227	0.329885047708805	SLC27A2/ACSS1	2
GO:0043425	bHLH transcription factor binding	2/274	27/18367	0.0609570196853227	0.329885047708805	KLF5/ISL1	2
GO:0070006	metalloaminopeptidase activity	2/274	27/18367	0.0609570196853227	0.329885047708805	ENPEP/MMP15	2
GO:0005507	copper ion binding	3/274	61/18367	0.0628381551049445	0.33676370502844	F5/GPC1/SOD3	3
GO:0008022	protein C-terminus binding	6/274	189/18367	0.0643792931151552	0.338583744265231	FBLN1/TBL1X/BCAM/ID1/DLG1/SIAH1	6
GO:0015293	symporter activity	5/274	144/18367	0.0648176771652039	0.338583744265231	SLC13A4/SLC16A12/SLC6A4/SLC5A6/SLC38A1	5
GO:0003785	actin monomer binding	2/274	28/18367	0.0650178929204973	0.338583744265231	PFN2/COBL	2
GO:0008237	metallopeptidase activity	6/274	190/18367	0.0656907120467024	0.33889040233439	ADAMTS6/ADAMTS1/MME/ADAMTS19/ENPEP/MMP15	6
GO:0008238	exopeptidase activity	4/274	103/18367	0.0683441911432674	0.349314754732256	MME/DPP4/ENPEP/MMP15	4
GO:0015294	solute:cation symporter activity	4/274	104/18367	0.070285029605848	0.355938865526863	SLC13A4/SLC6A4/SLC5A6/SLC38A1	4
GO:0005310	dicarboxylic acid transmembrane transporter activity	2/274	30/18367	0.0733999599165264	0.364153581608804	SLC26A2/SLC19A1	2
GO:0022829	wide pore channel activity	2/274	30/18367	0.0733999599165264	0.364153581608804	GJA1/GJA5	2
GO:0016829	lyase activity	6/274	196/18367	0.0738862339496123	0.364153581608804	HACD3/MOCS1/MGST3/FAHD2A/PISD/GLDC	6
GO:0016878	acid-thiol ligase activity	2/274	31/18367	0.0777142270819427	0.373028289993325	SLC27A2/ACSS1	2
GO:0042910	xenobiotic transmembrane transporter activity	2/274	31/18367	0.0777142270819427	0.373028289993325	SLC19A1/SLC2A1	2
GO:0140318	protein transporter activity	2/274	31/18367	0.0777142270819427	0.373028289993325	LRP2/IGF1R	2
GO:0008378	galactosyltransferase activity	2/274	32/18367	0.0821061711343688	0.385999509167482	B3GNT3/C1GALT1	2
GO:0015605	organophosphate ester transmembrane transporter activity	2/274	32/18367	0.0821061711343688	0.385999509167482	SLC19A1/SLC25A4	2
GO:0047485	protein N-terminus binding	4/274	110/18367	0.0825143878292806	0.385999509167482	RPS21/ID1/TAF11/VPS25	4
GO:0022804	active transmembrane transporter activity	10/274	406/18367	0.0839945074359952	0.389382400342947	SLC26A2/SLC22A11/SLC13A4/SLC19A1/SLC16A12/SLC6A4/SLC25A1/SLC25A4/SLC5A6/SLC38A1	10
GO:0032182	ubiquitin-like protein binding	4/274	111/18367	0.0846483479006406	0.389382400342947	TDG/N4BP2/FAF2/CBX4	4
GO:0019956	chemokine binding	2/274	33/18367	0.0865725344856309	0.394942471372465	ITGB1/ITGAV	2
GO:0048029	monosaccharide binding	3/274	71/18367	0.0897600304549505	0.406127350910923	PLOD2/LMAN1/BSG	3
GO:0106306	protein serine phosphatase activity	3/274	73/18367	0.0956394634592518	0.425749869592798	DUSP9/CTDSPL/PHLPP1	3
GO:0106307	protein threonine phosphatase activity	3/274	73/18367	0.0956394634592518	0.425749869592798	DUSP9/CTDSPL/PHLPP1	3
GO:0005254	chloride channel activity	3/274	74/18367	0.0986369376583504	0.435580716699276	GABRE/CLDN4/FXYD3	3
GO:0043394	proteoglycan binding	2/274	36/18367	0.100386743771153	0.436326634343909	PTPRF/CTSL	2
GO:0097718	disordered domain specific binding	2/274	36/18367	0.100386743771153	0.436326634343909	GJA1/GJA5	2
GO:0005109	frizzled binding	2/274	37/18367	0.105119769625265	0.453329006508954	RNF43/ZNRF3	2
GO:0015175	neutral amino acid transmembrane transporter activity	2/274	38/18367	0.109912083822272	0.462483441929049	SLC38A1/SLC38A9	2
GO:0016757	glycosyltransferase activity	7/274	270/18367	0.110476382447688	0.462483441929049	EXTL2/CHPF/AGL/GALNT11/B3GNT3/TMTC3/C1GALT1	7
GO:0016776	phosphotransferase activity, phosphate group as acceptor	2/274	39/18367	0.114760880609086	0.462483441929049	DLG1/PMVK	2
GO:1901981	phosphatidylinositol phosphate binding	5/274	173/18367	0.117430086322926	0.462483441929049	PFN2/SVIL/SYT7/PHLDA2/ARHGAP32	5
GO:0046982	protein heterodimerization activity	8/274	328/18367	0.118953634681299	0.462483441929049	TENM3/P4HB/JAM3/ITGB1/ADRB1/PRMT5/TAF11/ERBB3	8
GO:0017080	sodium channel regulator activity	2/274	40/18367	0.119663424195726	0.462483441929049	FXYD3/PRSS8	2
GO:0031406	carboxylic acid binding	5/274	176/18367	0.123771701634367	0.462483441929049	SLC19A1/FOLR1/NR2F2/PLOD2/GLDC	5
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	3/274	82/18367	0.123914505000153	0.462483441929049	PFN2/SVIL/SYT7	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	2/274	41/18367	0.124617047305068	0.462483441929049	SLC27A2/ACSS1	2
GO:0019205	nucleobase-containing compound kinase activity	2/274	42/18367	0.129619149750034	0.462483441929049	DLG1/N4BP2	2
GO:0016209	antioxidant activity	3/274	86/18367	0.13734728794683	0.462483441929049	SOD3/GPX8/MGST3	3
GO:0042562	hormone binding	3/274	86/18367	0.13734728794683	0.462483441929049	LRP2/EGFR/IGF1R	3
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	10/274	450/18367	0.137391732361145	0.462483441929049	TFDP2/ESRRG/KLF5/ISL1/NFIB/PBX1/GATA3/ZFAT/TFCP2L1/TFAP2C	10
GO:0008239	dipeptidyl-peptidase activity	1/274	10/18367	0.139586031163158	0.462483441929049	DPP4	1
GO:0008330	protein tyrosine/threonine phosphatase activity	1/274	10/18367	0.139586031163158	0.462483441929049	DUSP9	1
GO:0015643	toxic substance binding	1/274	10/18367	0.139586031163158	0.462483441929049	EPHX2	1
GO:0015924	mannosyl-oligosaccharide mannosidase activity	1/274	10/18367	0.139586031163158	0.462483441929049	MAN2A1	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1/274	10/18367	0.139586031163158	0.462483441929049	FADS3	1
GO:0016783	sulfurtransferase activity	1/274	10/18367	0.139586031163158	0.462483441929049	MPST	1
GO:0016803	ether hydrolase activity	1/274	10/18367	0.139586031163158	0.462483441929049	EPHX2	1
GO:0019531	oxalate transmembrane transporter activity	1/274	10/18367	0.139586031163158	0.462483441929049	SLC26A2	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	1/274	10/18367	0.139586031163158	0.462483441929049	SLC27A2	1
GO:0034511	U3 snoRNA binding	1/274	10/18367	0.139586031163158	0.462483441929049	PRKDC	1
GO:0070567	cytidylyltransferase activity	1/274	10/18367	0.139586031163158	0.462483441929049	CDS1	1
GO:0099528	G protein-coupled neurotransmitter receptor activity	1/274	10/18367	0.139586031163158	0.462483441929049	ADRB1	1
GO:0008375	acetylglucosaminyltransferase activity	2/274	44/18367	0.13975871900012	0.462483441929049	EXTL2/B3GNT3	2
GO:0003727	single-stranded RNA binding	3/274	87/18367	0.14078068696051	0.462483441929049	RBPMS/L1TD1/CBX4	3
GO:0005253	anion channel activity	3/274	87/18367	0.14078068696051	0.462483441929049	GABRE/CLDN4/FXYD3	3
GO:0002020	protease binding	4/274	135/18367	0.143372414172768	0.462483441929049	ADAMTSL4/DPP4/ITGB1/ITGAV	4
GO:0001216	DNA-binding transcription activator activity	10/274	456/18367	0.145818304669582	0.462483441929049	TFDP2/ESRRG/KLF5/ISL1/NFIB/PBX1/GATA3/ZFAT/TFCP2L1/TFAP2C	10
GO:0015297	antiporter activity	3/274	89/18367	0.14773285342851	0.462483441929049	SLC26A2/SLC19A1/SLC25A4	3
GO:0002162	dystroglycan binding	1/274	11/18367	0.152428730267657	0.462483441929049	DAG1	1
GO:0005347	ATP transmembrane transporter activity	1/274	11/18367	0.152428730267657	0.462483441929049	SLC25A4	1
GO:0008199	ferric iron binding	1/274	11/18367	0.152428730267657	0.462483441929049	FTL	1
GO:0008503	benzodiazepine receptor activity	1/274	11/18367	0.152428730267657	0.462483441929049	GABRE	1
GO:0015378	sodium:chloride symporter activity	1/274	11/18367	0.152428730267657	0.462483441929049	SLC6A4	1
GO:0016273	arginine N-methyltransferase activity	1/274	11/18367	0.152428730267657	0.462483441929049	PRMT5	1
GO:0016274	protein-arginine N-methyltransferase activity	1/274	11/18367	0.152428730267657	0.462483441929049	PRMT5	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	1/274	11/18367	0.152428730267657	0.462483441929049	P4HB	1
GO:0016801	hydrolase activity, acting on ether bonds	1/274	11/18367	0.152428730267657	0.462483441929049	EPHX2	1
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	1/274	11/18367	0.152428730267657	0.462483441929049	HSD17B1	1
GO:0031434	mitogen-activated protein kinase kinase binding	1/274	11/18367	0.152428730267657	0.462483441929049	DLG1	1
GO:0035673	oligopeptide transmembrane transporter activity	1/274	11/18367	0.152428730267657	0.462483441929049	GJA1	1
GO:0043560	insulin receptor substrate binding	1/274	11/18367	0.152428730267657	0.462483441929049	IGF1R	1
GO:0047676	arachidonate-CoA ligase activity	1/274	11/18367	0.152428730267657	0.462483441929049	SLC27A2	1
GO:0048407	platelet-derived growth factor binding	1/274	11/18367	0.152428730267657	0.462483441929049	COL4A1	1
GO:0061665	SUMO ligase activity	1/274	11/18367	0.152428730267657	0.462483441929049	CBX4	1
GO:0099186	structural constituent of postsynapse	1/274	11/18367	0.152428730267657	0.462483441929049	DLG1	1
GO:1901474	azole transmembrane transporter activity	1/274	11/18367	0.152428730267657	0.462483441929049	SLC19A3	1
GO:1901612	cardiolipin binding	1/274	11/18367	0.152428730267657	0.462483441929049	MME	1
GO:0099106	ion channel regulator activity	4/274	139/18367	0.154417366831174	0.462483441929049	FXYD3/DLG1/RASA1/PRSS8	4
GO:0030674	protein-macromolecule adaptor activity	7/274	296/18367	0.155196433890602	0.462483441929049	COL14A1/SYNE2/AP1S3/DLG5/DDB1/MPP7/OBSL1	7
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/274	47/18367	0.155270368093872	0.462483441929049	GABRE/ADRB1	2
GO:0042393	histone binding	6/274	244/18367	0.158704722242403	0.462483441929049	TBL1X/MORC4/BRD4/CTSL/SMARCA2/CBX4	6
GO:0070888	E-box binding	2/274	48/18367	0.160512327084872	0.462483441929049	PRMT5/GATA3	2
GO:0003995	acyl-CoA dehydrogenase activity	1/274	12/18367	0.165080426056863	0.462483441929049	ACADS	1
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	1/274	12/18367	0.165080426056863	0.462483441929049	CDKN1C	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	1/274	12/18367	0.165080426056863	0.462483441929049	BRD4	1
GO:0008429	phosphatidylethanolamine binding	1/274	12/18367	0.165080426056863	0.462483441929049	NF1	1
GO:0015269	calcium-activated potassium channel activity	1/274	12/18367	0.165080426056863	0.462483441929049	KCNN4	1
GO:0017154	semaphorin receptor activity	1/274	12/18367	0.165080426056863	0.462483441929049	MET	1
GO:0017166	vinculin binding	1/274	12/18367	0.165080426056863	0.462483441929049	DAG1	1
GO:0031543	peptidyl-proline dioxygenase activity	1/274	12/18367	0.165080426056863	0.462483441929049	P4HB	1
GO:0043176	amine binding	1/274	12/18367	0.165080426056863	0.462483441929049	SLC6A4	1
GO:0051378	serotonin binding	1/274	12/18367	0.165080426056863	0.462483441929049	SLC6A4	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	3/274	94/18367	0.165578821651974	0.462483441929049	AGL/GANAB/MAN2A1	3
GO:0008194	UDP-glycosyltransferase activity	4/274	143/18367	0.165771287061868	0.462483441929049	EXTL2/CHPF/GALNT11/B3GNT3	4
GO:0016798	hydrolase activity, acting on glycosyl bonds	4/274	144/18367	0.168655675916058	0.462483441929049	TDG/AGL/GANAB/MAN2A1	4
GO:0015932	nucleobase-containing compound transmembrane transporter activity	2/274	50/18367	0.171090261230165	0.462483441929049	SLC19A1/SLC25A4	2
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	2/274	50/18367	0.171090261230165	0.462483441929049	TDG/MAN2A1	2
GO:0016247	channel regulator activity	4/274	145/18367	0.171557789084669	0.462483441929049	FXYD3/DLG1/RASA1/PRSS8	4
GO:0004601	peroxidase activity	2/274	51/18367	0.176422068720698	0.462483441929049	GPX8/MGST3	2
GO:0008195	phosphatidate phosphatase activity	1/274	13/18367	0.17754394898034	0.462483441929049	PLPP3	1
GO:0016594	glycine binding	1/274	13/18367	0.17754394898034	0.462483441929049	GLDC	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	1/274	13/18367	0.17754394898034	0.462483441929049	DUSP9	1
GO:0019104	DNA N-glycosylase activity	1/274	13/18367	0.17754394898034	0.462483441929049	TDG	1
GO:0022851	GABA-gated chloride ion channel activity	1/274	13/18367	0.17754394898034	0.462483441929049	GABRE	1
GO:0031404	chloride ion binding	1/274	13/18367	0.17754394898034	0.462483441929049	TDG	1
GO:0045159	myosin II binding	1/274	13/18367	0.17754394898034	0.462483441929049	TRIOBP	1
GO:0070700	BMP receptor binding	1/274	13/18367	0.17754394898034	0.462483441929049	BMP7	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/274	13/18367	0.17754394898034	0.462483441929049	HSD17B1	1
GO:0019842	vitamin binding	4/274	148/18367	0.180367250098692	0.462483441929049	SLC19A1/FOLR1/PLOD2/GLDC	4
GO:0004879	nuclear receptor activity	2/274	52/18367	0.181779749275751	0.462483441929049	ESRRG/NR2F2	2
GO:0016830	carbon-carbon lyase activity	2/274	52/18367	0.181779749275751	0.462483441929049	MOCS1/PISD	2
GO:0098531	ligand-activated transcription factor activity	2/274	52/18367	0.181779749275751	0.462483441929049	ESRRG/NR2F2	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	2/274	53/18367	0.187161354167543	0.462483441929049	SLC19A1/SLC25A4	2
GO:0060090	molecular adaptor activity	8/274	369/18367	0.187797320077443	0.462483441929049	COL14A1/SYNE2/DLG1/AP1S3/DLG5/DDB1/MPP7/OBSL1	8
GO:0004065	arylsulfatase activity	1/274	14/18367	0.189822087695573	0.462483441929049	STS	1
GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	1/274	14/18367	0.189822087695573	0.462483441929049	B3GNT3	1
GO:0015562	efflux transmembrane transporter activity	1/274	14/18367	0.189822087695573	0.462483441929049	GJA1	1
GO:0030983	mismatched DNA binding	1/274	14/18367	0.189822087695573	0.462483441929049	TDG	1
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	1/274	14/18367	0.189822087695573	0.462483441929049	HSD17B1	1
GO:0071837	HMG box domain binding	1/274	14/18367	0.189822087695573	0.462483441929049	GATA3	1
GO:0015081	sodium ion transmembrane transporter activity	4/274	152/18367	0.19234169700816	0.462483441929049	SLC13A4/SLC6A4/SLC5A6/SLC38A1	4
GO:0015459	potassium channel regulator activity	2/274	54/18367	0.19256498665473	0.462483441929049	DLG1/RASA1	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	2/274	54/18367	0.19256498665473	0.462483441929049	P4HB/PLOD2	2
GO:0004725	protein tyrosine phosphatase activity	3/274	102/18367	0.195336895906543	0.462483441929049	PTPRF/DUSP9/PTPN14	3
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	2/274	55/18367	0.197988800874624	0.462483441929049	GPX8/MGST3	2
GO:0001846	opsonin binding	1/274	15/18367	0.201917589682791	0.462483441929049	ITGAV	1
GO:0004467	long-chain fatty acid-CoA ligase activity	1/274	15/18367	0.201917589682791	0.462483441929049	SLC27A2	1
GO:0004559	alpha-mannosidase activity	1/274	15/18367	0.201917589682791	0.462483441929049	MAN2A1	1
GO:0005041	low-density lipoprotein particle receptor activity	1/274	15/18367	0.201917589682791	0.462483441929049	LRP2	1
GO:0005237	inhibitory extracellular ligand-gated ion channel activity	1/274	15/18367	0.201917589682791	0.462483441929049	GABRE	1
GO:0005452	inorganic anion exchanger activity	1/274	15/18367	0.201917589682791	0.462483441929049	SLC22A11	1
GO:0016846	carbon-sulfur lyase activity	1/274	15/18367	0.201917589682791	0.462483441929049	MGST3	1
GO:0032794	GTPase activating protein binding	1/274	15/18367	0.201917589682791	0.462483441929049	CDH1	1
GO:0034483	heparan sulfate sulfotransferase activity	1/274	15/18367	0.201917589682791	0.462483441929049	HS6ST2	1
GO:0042809	vitamin D receptor binding	1/274	15/18367	0.201917589682791	0.462483441929049	TAF11	1
GO:0042813	Wnt-activated receptor activity	1/274	15/18367	0.201917589682791	0.462483441929049	LRP5	1
GO:0048185	activin binding	1/274	15/18367	0.201917589682791	0.462483441929049	TGFBR3	1
GO:0050998	nitric-oxide synthase binding	1/274	15/18367	0.201917589682791	0.462483441929049	SLC6A4	1
GO:1901611	phosphatidylglycerol binding	1/274	15/18367	0.201917589682791	0.462483441929049	MME	1
GO:1904680	peptide transmembrane transporter activity	1/274	15/18367	0.201917589682791	0.462483441929049	GJA1	1
GO:0030546	signaling receptor activator activity	10/274	495/18367	0.206645334779693	0.471356300819795	FBN1/SEMA6A/APP/EFEMP1/BMP7/DPP4/CMTM8/SEMA6D/LRPAP1/FAM3B	10
GO:0005283	amino acid:sodium symporter activity	1/274	16/18367	0.213833161850779	0.474923907857869	SLC38A1	1
GO:0005523	tropomyosin binding	1/274	16/18367	0.213833161850779	0.474923907857869	CALD1	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/274	16/18367	0.213833161850779	0.474923907857869	SLC22A11	1
GO:0015923	mannosidase activity	1/274	16/18367	0.213833161850779	0.474923907857869	MAN2A1	1
GO:0016004	phospholipase activator activity	1/274	16/18367	0.213833161850779	0.474923907857869	PDPK1	1
GO:0016208	AMP binding	1/274	16/18367	0.213833161850779	0.474923907857869	ACSS1	1
GO:1902936	phosphatidylinositol bisphosphate binding	3/274	107/18367	0.214557229227287	0.474923907857869	PFN2/SVIL/SYT7	3
GO:0140030	modification-dependent protein binding	4/274	160/18367	0.216995555518949	0.474923907857869	MORC4/AGL/BRD4/CBX4	4
GO:0001786	phosphatidylserine binding	2/274	60/18367	0.225349419119408	0.474923907857869	MME/SYT7	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	2/274	60/18367	0.225349419119408	0.474923907857869	DHCR24/ACADS	2
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	1/274	17/18367	0.225571471133809	0.474923907857869	PTPRF	1
GO:0005005	transmembrane-ephrin receptor activity	1/274	17/18367	0.225571471133809	0.474923907857869	EPHB4	1
GO:0008484	sulfuric ester hydrolase activity	1/274	17/18367	0.225571471133809	0.474923907857869	STS	1
GO:0015108	chloride transmembrane transporter activity	1/274	17/18367	0.225571471133809	0.474923907857869	SLC26A2	1
GO:0015174	basic amino acid transmembrane transporter activity	1/274	17/18367	0.225571471133809	0.474923907857869	SLC38A9	1
GO:0015377	cation:chloride symporter activity	1/274	17/18367	0.225571471133809	0.474923907857869	SLC6A4	1
GO:0019198	transmembrane receptor protein phosphatase activity	1/274	17/18367	0.225571471133809	0.474923907857869	PTPRF	1
GO:0031420	alkali metal ion binding	1/274	17/18367	0.225571471133809	0.474923907857869	TDG	1
GO:0050780	dopamine receptor binding	1/274	17/18367	0.225571471133809	0.474923907857869	GNA12	1
GO:0070628	proteasome binding	1/274	17/18367	0.225571471133809	0.474923907857869	ID1	1
GO:0008047	enzyme activator activity	3/274	110/18367	0.226277151751122	0.474923907857869	DDOST/MMP15/PDPK1	3
GO:0015179	L-amino acid transmembrane transporter activity	2/274	61/18367	0.230858275526678	0.475994909396589	SLC38A1/SLC38A9	2
GO:0043621	protein self-association	2/274	61/18367	0.230858275526678	0.475994909396589	TDG/SLC2A1	2
GO:0098960	postsynaptic neurotransmitter receptor activity	2/274	62/18367	0.236375728550615	0.475994909396589	GABRE/ADRB1	2
GO:1990841	promoter-specific chromatin binding	2/274	62/18367	0.236375728550615	0.475994909396589	ISL1/DNMT1	2
GO:0004303	estradiol 17-beta-dehydrogenase activity	1/274	18/18367	0.237135145079822	0.475994909396589	HSD17B1	1
GO:0016755	aminoacyltransferase activity	1/274	18/18367	0.237135145079822	0.475994909396589	TGM2	1
GO:0030228	lipoprotein particle receptor activity	1/274	18/18367	0.237135145079822	0.475994909396589	LRP2	1
GO:0033549	MAP kinase phosphatase activity	1/274	18/18367	0.237135145079822	0.475994909396589	DUSP9	1
GO:0055102	lipase inhibitor activity	1/274	18/18367	0.237135145079822	0.475994909396589	FAF2	1
GO:0060229	lipase activator activity	1/274	18/18367	0.237135145079822	0.475994909396589	PDPK1	1
GO:0098918	structural constituent of synapse	1/274	18/18367	0.237135145079822	0.475994909396589	DLG1	1
GO:0099095	ligand-gated anion channel activity	1/274	18/18367	0.237135145079822	0.475994909396589	GABRE	1
GO:0016836	hydro-lyase activity	2/274	64/18367	0.247430561315956	0.485389747253054	HACD3/FAHD2A	2
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	1/274	19/18367	0.248526772429985	0.485389747253054	GALNT11	1
GO:0004890	GABA-A receptor activity	1/274	19/18367	0.248526772429985	0.485389747253054	GABRE	1
GO:0005003	ephrin receptor activity	1/274	19/18367	0.248526772429985	0.485389747253054	EPHB4	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/274	19/18367	0.248526772429985	0.485389747253054	SLC6A4	1
GO:0035613	RNA stem-loop binding	1/274	19/18367	0.248526772429985	0.485389747253054	MYH10	1
GO:0035615	clathrin adaptor activity	1/274	19/18367	0.248526772429985	0.485389747253054	AP1S3	1
GO:0033218	amide binding	8/274	400/18367	0.248850178392417	0.485389747253054	MME/SLC19A1/IGF1R/FOLR1/LRPAP1/ITM2C/ENPEP/DHCR24	8
GO:0002039	p53 binding	2/274	66/18367	0.258502603915987	0.486038626565228	BRD4/PRMT5	2
GO:0001972	retinoic acid binding	1/274	20/18367	0.259748903689751	0.486038626565228	NR2F2	1
GO:0003756	protein disulfide isomerase activity	1/274	20/18367	0.259748903689751	0.486038626565228	P4HB	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	1/274	20/18367	0.259748903689751	0.486038626565228	GLDC	1
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	1/274	20/18367	0.259748903689751	0.486038626565228	CDS1	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	1/274	20/18367	0.259748903689751	0.486038626565228	P4HB	1
GO:0030296	protein tyrosine kinase activator activity	1/274	20/18367	0.259748903689751	0.486038626565228	ERBB3	1
GO:0030506	ankyrin binding	1/274	20/18367	0.259748903689751	0.486038626565228	CDH1	1
GO:0031418	L-ascorbic acid binding	1/274	20/18367	0.259748903689751	0.486038626565228	PLOD2	1
GO:0031690	adrenergic receptor binding	1/274	20/18367	0.259748903689751	0.486038626565228	ADRB1	1
GO:0050145	nucleoside monophosphate kinase activity	1/274	20/18367	0.259748903689751	0.486038626565228	DLG1	1
GO:0140312	cargo adaptor activity	1/274	20/18367	0.259748903689751	0.486038626565228	AP1S3	1
GO:0004252	serine-type endopeptidase activity	4/274	174/18367	0.261965373898761	0.488530021594988	DPP4/PRSS8/MBTPS1/IMMP2L	4
GO:0051020	GTPase binding	6/274	291/18367	0.268453409823696	0.493345995160843	RAB11FIP4/CDKL5/FNBP1L/RASA1/ERRFI1/TRIOBP	6
GO:0003684	damaged DNA binding	2/274	68/18367	0.269581183254018	0.493345995160843	TDG/DDB1	2
GO:0016782	transferase activity, transferring sulphur-containing groups	2/274	68/18367	0.269581183254018	0.493345995160843	HS6ST2/MPST	2
GO:0051010	microtubule plus-end binding	1/274	21/18367	0.27080405169155	0.493345995160843	CLIP1	1
GO:0070577	lysine-acetylated histone binding	1/274	21/18367	0.27080405169155	0.493345995160843	BRD4	1
GO:0140033	acetylation-dependent protein binding	1/274	21/18367	0.27080405169155	0.493345995160843	BRD4	1
GO:0140416	transcription regulator inhibitor activity	1/274	21/18367	0.27080405169155	0.493345995160843	ID1	1
GO:0051082	unfolded protein binding	3/274	122/18367	0.274194459731615	0.496790639189688	LMAN1/SERPINH1/PDRG1	3
GO:0001664	G protein-coupled receptor binding	6/274	295/18367	0.278610671704433	0.496790639189688	ITGB4/RNF43/ZNRF3/GNA12/ADRB1/GNA11	6
GO:0005355	glucose transmembrane transporter activity	1/274	22/18367	0.281694692149225	0.496790639189688	SLC2A1	1
GO:0005416	amino acid:cation symporter activity	1/274	22/18367	0.281694692149225	0.496790639189688	SLC38A1	1
GO:0008093	cytoskeletal anchor activity	1/274	22/18367	0.281694692149225	0.496790639189688	OBSL1	1
GO:0015106	bicarbonate transmembrane transporter activity	1/274	22/18367	0.281694692149225	0.496790639189688	SLC26A2	1
GO:0015149	hexose transmembrane transporter activity	1/274	22/18367	0.281694692149225	0.496790639189688	SLC2A1	1
GO:0015645	fatty acid ligase activity	1/274	22/18367	0.281694692149225	0.496790639189688	SLC27A2	1
GO:0016917	GABA receptor activity	1/274	22/18367	0.281694692149225	0.496790639189688	GABRE	1
GO:0017075	syntaxin-1 binding	1/274	22/18367	0.281694692149225	0.496790639189688	SLC6A4	1
GO:0008235	metalloexopeptidase activity	2/274	72/18367	0.291718296198979	0.5037701155795	ENPEP/MMP15	2
GO:0030276	clathrin binding	2/274	72/18367	0.291718296198979	0.5037701155795	SYT7/AP1S3	2
GO:0106310	protein serine kinase activity	7/274	360/18367	0.292003909104414	0.5037701155795	MAST4/CAMK2G/MAP3K4/CDKL5/MAP3K13/PRKDC/PDPK1	7
GO:0008143	poly(A) binding	1/274	23/18367	0.292423264204342	0.5037701155795	RBPMS	1
GO:0016849	phosphorus-oxygen lyase activity	1/274	23/18367	0.292423264204342	0.5037701155795	MOCS1	1
GO:0017025	TBP-class protein binding	1/274	23/18367	0.292423264204342	0.5037701155795	TAF11	1
GO:0050750	low-density lipoprotein particle receptor binding	1/274	23/18367	0.292423264204342	0.5037701155795	LRPAP1	1
GO:0035064	methylated histone binding	2/274	73/18367	0.297241643600098	0.5037701155795	MORC4/CBX4	2
GO:0140034	methylation-dependent protein binding	2/274	73/18367	0.297241643600098	0.5037701155795	MORC4/CBX4	2
GO:0140678	molecular function inhibitor activity	3/274	128/18367	0.298556862598723	0.5037701155795	ID1/RASA1/FAF2	3
GO:0017022	myosin binding	2/274	74/18367	0.302758440987369	0.5037701155795	CALD1/TRIOBP	2
GO:0019905	syntaxin binding	2/274	74/18367	0.302758440987369	0.5037701155795	SLC6A4/SYT7	2
GO:0000030	mannosyltransferase activity	1/274	24/18367	0.302992170964482	0.5037701155795	TMTC3	1
GO:0003707	steroid hormone receptor activity	1/274	24/18367	0.302992170964482	0.5037701155795	ESRRG	1
GO:0015145	monosaccharide transmembrane transporter activity	1/274	24/18367	0.302992170964482	0.5037701155795	SLC2A1	1
GO:0019789	SUMO transferase activity	1/274	24/18367	0.302992170964482	0.5037701155795	CBX4	1
GO:0043274	phospholipase binding	1/274	24/18367	0.302992170964482	0.5037701155795	PDPK1	1
GO:0043495	protein-membrane adaptor activity	1/274	24/18367	0.302992170964482	0.5037701155795	SYNE2	1
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	1/274	24/18367	0.302992170964482	0.5037701155795	BMP7	1
GO:0048018	receptor ligand activity	9/274	487/18367	0.303935614612444	0.503821198997204	FBN1/SEMA6A/EFEMP1/BMP7/DPP4/CMTM8/SEMA6D/LRPAP1/FAM3B	9
GO:0017124	SH3 domain binding	3/274	130/18367	0.306708551141967	0.506895569551994	LRP2/GJA1/ERRFI1	3
GO:0046873	metal ion transmembrane transporter activity	8/274	430/18367	0.313125411845161	0.510321199346827	SLC13A4/SLC6A4/CNNM2/TUSC3/KCNN4/SLC5A6/SLC38A1/ITGAV	8
GO:0005112	Notch binding	1/274	25/18367	0.313403780033649	0.510321199346827	GALNT11	1
GO:0005160	transforming growth factor beta receptor binding	1/274	25/18367	0.313403780033649	0.510321199346827	TGFBR3	1
GO:0005227	calcium activated cation channel activity	1/274	25/18367	0.313403780033649	0.510321199346827	KCNN4	1
GO:0030247	polysaccharide binding	1/274	25/18367	0.313403780033649	0.510321199346827	AGL	1
GO:0008236	serine-type peptidase activity	4/274	191/18367	0.318604539158924	0.516806979972562	DPP4/PRSS8/MBTPS1/IMMP2L	4
GO:0038024	cargo receptor activity	2/274	77/18367	0.319259384367108	0.516806979972562	LRP2/FOLR1	2
GO:0008198	ferrous iron binding	1/274	26/18367	0.323660424034891	0.519362075776918	FTL	1
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	1/274	26/18367	0.323660424034891	0.519362075776918	SLC26A2	1
GO:0097602	cullin family protein binding	1/274	26/18367	0.323660424034891	0.519362075776918	DDB1	1
GO:0016835	carbon-oxygen lyase activity	2/274	79/18367	0.33020920453774	0.520446184805489	HACD3/FAHD2A	2
GO:0046332	SMAD binding	2/274	79/18367	0.33020920453774	0.520446184805489	EID2/TGFBR3	2
GO:0017171	serine hydrolase activity	4/274	195/18367	0.332106930479988	0.520446184805489	DPP4/PRSS8/MBTPS1/IMMP2L	4
GO:0004190	aspartic-type endopeptidase activity	1/274	27/18367	0.333764401125259	0.520446184805489	SPPL2B	1
GO:0004683	calmodulin-dependent protein kinase activity	1/274	27/18367	0.333764401125259	0.520446184805489	CAMK2G	1
GO:0023026	MHC class II protein complex binding	1/274	27/18367	0.333764401125259	0.520446184805489	B2M	1
GO:0048027	mRNA 5'-UTR binding	1/274	27/18367	0.333764401125259	0.520446184805489	MYH10	1
GO:0051119	sugar transmembrane transporter activity	1/274	27/18367	0.333764401125259	0.520446184805489	SLC2A1	1
GO:0051393	alpha-actinin binding	1/274	27/18367	0.333764401125259	0.520446184805489	DAG1	1
GO:0051959	dynein light intermediate chain binding	1/274	27/18367	0.333764401125259	0.520446184805489	HOOK1	1
GO:0019902	phosphatase binding	4/274	196/18367	0.33548773370298	0.521659800011395	EGFR/MET/DLG1/KCNN4	4
GO:0035591	signaling adaptor activity	2/274	81/18367	0.341109976679691	0.528502291024439	DLG5/MPP7	2
GO:0015101	organic cation transmembrane transporter activity	1/274	28/18367	0.343717975503213	0.528502291024439	SLC19A3	1
GO:0070001	aspartic-type peptidase activity	1/274	28/18367	0.343717975503213	0.528502291024439	SPPL2B	1
GO:0070325	lipoprotein particle receptor binding	1/274	28/18367	0.343717975503213	0.528502291024439	LRPAP1	1
GO:0042277	peptide binding	6/274	321/18367	0.346380053017623	0.531116081293688	MME/IGF1R/LRPAP1/ITM2C/ENPEP/DHCR24	6
GO:0070851	growth factor receptor binding	3/274	141/18367	0.351596729010966	0.531729985301197	APP/EFEMP1/GATA3	3
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	1/274	29/18367	0.353523377908585	0.531729985301197	CDKL5	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	1/274	29/18367	0.353523377908585	0.531729985301197	DHCR24	1
GO:0033612	receptor serine/threonine kinase binding	1/274	29/18367	0.353523377908585	0.531729985301197	BMP7	1
GO:0035250	UDP-galactosyltransferase activity	1/274	29/18367	0.353523377908585	0.531729985301197	B3GNT3	1
GO:0070717	poly-purine tract binding	1/274	29/18367	0.353523377908585	0.531729985301197	RBPMS	1
GO:0097472	cyclin-dependent protein kinase activity	1/274	29/18367	0.353523377908585	0.531729985301197	CDKL5	1
GO:0001540	amyloid-beta binding	2/274	84/18367	0.357354666589221	0.534579338637534	LRPAP1/ITM2C	2
GO:0015171	amino acid transmembrane transporter activity	2/274	84/18367	0.357354666589221	0.534579338637534	SLC38A1/SLC38A9	2
GO:0050660	flavin adenine dinucleotide binding	2/274	85/18367	0.362738073642945	0.535519555597156	DHCR24/ACADS	2
GO:0005343	organic acid:sodium symporter activity	1/274	30/18367	0.363182806115208	0.535519555597156	SLC38A1	1
GO:0017147	Wnt-protein binding	1/274	30/18367	0.363182806115208	0.535519555597156	LRP5	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/274	30/18367	0.363182806115208	0.535519555597156	HSD17B1	1
GO:0046966	thyroid hormone receptor binding	1/274	30/18367	0.363182806115208	0.535519555597156	TAF11	1
GO:0016922	nuclear receptor binding	3/274	144/18367	0.363804045921981	0.535519555597156	ISL1/TACC2/TAF11	3
GO:0000146	microfilament motor activity	1/274	31/18367	0.372698425416317	0.545701673288612	MYH10	1
GO:0031210	phosphatidylcholine binding	1/274	31/18367	0.372698425416317	0.545701673288612	NF1	1
GO:0051219	phosphoprotein binding	2/274	88/18367	0.378783794753687	0.550663048941939	RASA1/CBX4	2
GO:0035091	phosphatidylinositol binding	5/274	271/18367	0.37961984867526	0.550663048941939	PFN2/SVIL/SYT7/PHLDA2/ARHGAP32	5
GO:0030515	snoRNA binding	1/274	32/18367	0.382072369102831	0.550663048941939	PRKDC	1
GO:0031624	ubiquitin conjugating enzyme binding	1/274	32/18367	0.382072369102831	0.550663048941939	SIAH1	1
GO:0048019	receptor antagonist activity	1/274	32/18367	0.382072369102831	0.550663048941939	LRPAP1	1
GO:0140658	ATP-dependent chromatin remodeler activity	1/274	32/18367	0.382072369102831	0.550663048941939	SMARCA2	1
GO:0005096	GTPase activator activity	8/274	462/18367	0.384851709766033	0.553224332788673	HACD3/NET1/ADRB1/RASA1/ERRFI1/ELMOD2/NF1/ARHGAP32	8
GO:0019903	protein phosphatase binding	3/274	150/18367	0.388098999292502	0.555001677744718	EGFR/MET/KCNN4	3
GO:0140677	molecular function activator activity	3/274	150/18367	0.388098999292502	0.555001677744718	DDOST/MMP15/PDPK1	3
GO:0005154	epidermal growth factor receptor binding	1/274	33/18367	0.391306738934619	0.556704432711107	EFEMP1	1
GO:0008200	ion channel inhibitor activity	1/274	33/18367	0.391306738934619	0.556704432711107	RASA1	1
GO:0043130	ubiquitin binding	2/274	92/18367	0.399909995924294	0.556732469254091	N4BP2/FAF2	2
GO:0051213	dioxygenase activity	2/274	92/18367	0.399909995924294	0.556732469254091	P4HB/PLOD2	2
GO:0015020	glucuronosyltransferase activity	1/274	34/18367	0.400403605604844	0.556732469254091	CHPF	1
GO:0016229	steroid dehydrogenase activity	1/274	34/18367	0.400403605604844	0.556732469254091	HSD17B1	1
GO:0016248	channel inhibitor activity	1/274	34/18367	0.400403605604844	0.556732469254091	RASA1	1
GO:0016831	carboxy-lyase activity	1/274	34/18367	0.400403605604844	0.556732469254091	PISD	1
GO:0030291	protein serine/threonine kinase inhibitor activity	1/274	34/18367	0.400403605604844	0.556732469254091	CDKN1C	1
GO:0035198	miRNA binding	1/274	34/18367	0.400403605604844	0.556732469254091	KCNQ1OT1	1
GO:0043548	phosphatidylinositol 3-kinase binding	1/274	34/18367	0.400403605604844	0.556732469254091	IGF1R	1
GO:0023023	MHC protein complex binding	1/274	36/18367	0.418192959638259	0.575667116509524	B2M	1
GO:0042605	peptide antigen binding	1/274	36/18367	0.418192959638259	0.575667116509524	DHCR24	1
GO:0042805	actinin binding	1/274	36/18367	0.418192959638259	0.575667116509524	DAG1	1
GO:0061631	ubiquitin conjugating enzyme activity	1/274	36/18367	0.418192959638259	0.575667116509524	AKTIP	1
GO:0004896	cytokine receptor activity	2/274	97/18367	0.42583497731046	0.580401402218025	CSF3R/LIFR	2
GO:0015035	protein-disulfide reductase activity	1/274	37/18367	0.42688943713862	0.580401402218025	P4HB	1
GO:0030551	cyclic nucleotide binding	1/274	37/18367	0.42688943713862	0.580401402218025	SLC19A1	1
GO:0043531	ADP binding	1/274	37/18367	0.42688943713862	0.580401402218025	MYH10	1
GO:0071949	FAD binding	1/274	37/18367	0.42688943713862	0.580401402218025	DHCR24	1
GO:0005501	retinoid binding	1/274	38/18367	0.435456392633657	0.586272996911655	NR2F2	1
GO:0016251	RNA polymerase II general transcription initiation factor activity	1/274	38/18367	0.435456392633657	0.586272996911655	TAF11	1
GO:0019840	isoprenoid binding	1/274	38/18367	0.435456392633657	0.586272996911655	NR2F2	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	1/274	38/18367	0.435456392633657	0.586272996911655	SIAH1	1
GO:0005496	steroid binding	2/274	100/18367	0.441108557556632	0.590434826539071	ESRRG/HSD17B1	2
GO:0030695	GTPase regulator activity	8/274	488/18367	0.443771109272268	0.590434826539071	HACD3/NET1/ADRB1/RASA1/ERRFI1/ELMOD2/NF1/ARHGAP32	8
GO:0060589	nucleoside-triphosphatase regulator activity	8/274	488/18367	0.443771109272268	0.590434826539071	HACD3/NET1/ADRB1/RASA1/ERRFI1/ELMOD2/NF1/ARHGAP32	8
GO:0050997	quaternary ammonium group binding	1/274	39/18367	0.443895748213251	0.590434826539071	NF1	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	1/274	39/18367	0.443895748213251	0.590434826539071	AKTIP	1
GO:0015144	carbohydrate transmembrane transporter activity	1/274	40/18367	0.452209397547033	0.598608123371613	SLC2A1	1
GO:0042169	SH2 domain binding	1/274	40/18367	0.452209397547033	0.598608123371613	DAG1	1
GO:0005200	structural constituent of cytoskeleton	2/274	103/18367	0.456156992524447	0.602389138453337	DSP/ADD3	2
GO:0030331	estrogen receptor binding	1/274	41/18367	0.460399206303083	0.606540243148691	ISL1	1
GO:1990782	protein tyrosine kinase binding	2/274	105/18367	0.46605927059629	0.609891016352315	ITGB1/PTPN14	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3/274	170/18367	0.467052497442283	0.609891016352315	P4HB/FADS3/PLOD2	3
GO:0008307	structural constituent of muscle	1/274	42/18367	0.468467012560474	0.609891016352315	DAG1	1
GO:0015036	disulfide oxidoreductase activity	1/274	42/18367	0.468467012560474	0.609891016352315	P4HB	1
GO:0051539	4 iron, 4 sulfur cluster binding	1/274	42/18367	0.468467012560474	0.609891016352315	MOCS1	1
GO:0030547	signaling receptor inhibitor activity	1/274	43/18367	0.476414627215777	0.618778527583786	LRPAP1	1
GO:0001784	phosphotyrosine residue binding	1/274	44/18367	0.484243834383583	0.624538777055462	RASA1	1
GO:0022839	ion gated channel activity	1/274	44/18367	0.484243834383583	0.624538777055462	KCNN4	1
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	1/274	44/18367	0.484243834383583	0.624538777055462	GABRE	1
GO:0000149	SNARE binding	2/274	110/18367	0.490341395204782	0.630069439138553	SLC6A4/SYT7	2
GO:0005245	voltage-gated calcium channel activity	1/274	45/18367	0.491956391791153	0.630069439138553	ITGAV	1
GO:0140223	general transcription initiation factor activity	1/274	45/18367	0.491956391791153	0.630069439138553	TAF11	1
GO:0030594	neurotransmitter receptor activity	2/274	111/18367	0.495114424746312	0.632646209398065	GABRE/ADRB1	2
GO:0061980	regulatory RNA binding	1/274	46/18367	0.49955403116727	0.635377477429339	KCNQ1OT1	1
GO:0140296	general transcription initiation factor binding	1/274	46/18367	0.49955403116727	0.635377477429339	TAF11	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	1/274	47/18367	0.507038458625388	0.643414319910837	DUSP9	1
GO:0061659	ubiquitin-like protein ligase activity	5/274	316/18367	0.510116361733527	0.645835393754373	RNF43/ZNRF3/MYLIP/SIAH1/CBX4	5
GO:0019787	ubiquitin-like protein transferase activity	7/274	458/18367	0.527580348754487	0.663440211739919	RNF43/KLHL42/ZNRF3/AKTIP/MYLIP/SIAH1/CBX4	7
GO:0000993	RNA polymerase II complex binding	1/274	50/18367	0.528829154285443	0.663440211739919	BRD4	1
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	1/274	50/18367	0.528829154285443	0.663440211739919	CDKN1C	1
GO:0030159	signaling receptor complex adaptor activity	1/274	50/18367	0.528829154285443	0.663440211739919	DLG5	1
GO:0008227	G protein-coupled amine receptor activity	1/274	51/18367	0.535877295996737	0.667342656128658	ADRB1	1
GO:0016860	intramolecular oxidoreductase activity	1/274	51/18367	0.535877295996737	0.667342656128658	P4HB	1
GO:0051018	protein kinase A binding	1/274	51/18367	0.535877295996737	0.667342656128658	DACT2	1
GO:0140297	DNA-binding transcription factor binding	6/274	394/18367	0.537110215255858	0.667342656128658	TDG/KLF5/ISL1/TACC2/TAF11/RBFOX2	6
GO:0031267	small GTPase binding	4/274	259/18367	0.542011036258388	0.667342656128658	RAB11FIP4/CDKL5/ERRFI1/TRIOBP	4
GO:0008146	sulfotransferase activity	1/274	52/18367	0.542820385148129	0.667342656128658	HS6ST2	1
GO:0016597	amino acid binding	1/274	52/18367	0.542820385148129	0.667342656128658	GLDC	1
GO:0017046	peptide hormone binding	1/274	52/18367	0.542820385148129	0.667342656128658	IGF1R	1
GO:0031593	polyubiquitin modification-dependent protein binding	1/274	52/18367	0.542820385148129	0.667342656128658	AGL	1
GO:0005543	phospholipid binding	7/274	466/18367	0.545981210878606	0.668029426270453	MME/PFN2/SVIL/SYT7/PHLDA2/NF1/ARHGAP32	7
GO:0019001	guanyl nucleotide binding	6/274	398/18367	0.547009602670733	0.668029426270453	SLC19A1/GNA12/MOCS1/TGM2/GNA11/IFI44L	6
GO:0032561	guanyl ribonucleotide binding	6/274	398/18367	0.547009602670733	0.668029426270453	SLC19A1/GNA12/MOCS1/TGM2/GNA11/IFI44L	6
GO:0050661	NADP binding	1/274	53/18367	0.549659981897756	0.668309052880091	HSD17B1	1
GO:1901618	organic hydroxy compound transmembrane transporter activity	1/274	53/18367	0.549659981897756	0.668309052880091	SLC6A4	1
GO:0005544	calcium-dependent phospholipid binding	1/274	54/18367	0.556397623317436	0.675014259497197	SYT7	1
GO:0030170	pyridoxal phosphate binding	1/274	55/18367	0.563034823733043	0.681568470834737	GLDC	1
GO:0030374	nuclear receptor coactivator activity	1/274	56/18367	0.569573075059886	0.683487690071863	DCAF6	1
GO:0042054	histone methyltransferase activity	1/274	56/18367	0.569573075059886	0.683487690071863	PRMT5	1
GO:0045309	protein phosphorylated amino acid binding	1/274	56/18367	0.569573075059886	0.683487690071863	RASA1	1
GO:0070279	vitamin B6 binding	1/274	56/18367	0.569573075059886	0.683487690071863	GLDC	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	1/274	57/18367	0.576013847133153	0.688224336834417	P4HB	1
GO:0043175	RNA polymerase core enzyme binding	1/274	57/18367	0.576013847133153	0.688224336834417	BRD4	1
GO:0015267	channel activity	7/274	480/18367	0.577439811091815	0.688437960524151	GABRE/GJA1/CLDN4/FXYD3/GJA5/KCNN4/ITGAV	7
GO:0022803	passive transmembrane transporter activity	7/274	481/18367	0.579647651347969	0.688777361929344	GABRE/GJA1/CLDN4/FXYD3/GJA5/KCNN4/ITGAV	7
GO:0015078	proton transmembrane transporter activity	2/274	130/18367	0.580220060320915	0.688777361929344	SLC25A4/ATP6V1B1	2
GO:0044325	transmembrane transporter binding	2/274	133/18367	0.592659812687877	0.701518472875413	TCAF1/DLG1	2
GO:0022824	transmitter-gated ion channel activity	1/274	60/18367	0.594765661785676	0.701518472875413	GABRE	1
GO:0022835	transmitter-gated channel activity	1/274	60/18367	0.594765661785676	0.701518472875413	GABRE	1
GO:0030145	manganese ion binding	1/274	65/18367	0.624200117879663	0.734666236822119	EXTL2	1
GO:0004842	ubiquitin-protein transferase activity	6/274	433/18367	0.629207254828854	0.738983839713888	RNF43/KLHL42/ZNRF3/AKTIP/MYLIP/SIAH1	6
GO:0097110	scaffold protein binding	1/274	67/18367	0.635368423087689	0.743694088441692	DSP	1
GO:0140375	immune receptor activity	2/274	144/18367	0.635912336493621	0.743694088441692	CSF3R/LIFR	2
GO:0051536	iron-sulfur cluster binding	1/274	68/18367	0.640827934129983	0.746280632151373	MOCS1	1
GO:0051540	metal cluster binding	1/274	68/18367	0.640827934129983	0.746280632151373	MOCS1	1
GO:0000287	magnesium ion binding	3/274	221/18367	0.643479755341479	0.747671741373981	TDG/MAST4/EPHX2	3
GO:0052689	carboxylic ester hydrolase activity	2/274	147/18367	0.647068176400522	0.747671741373981	PGAP1/PON2	2
GO:0031625	ubiquitin protein ligase binding	4/274	297/18367	0.649733234743421	0.747671741373981	EGFR/FAF2/TRIOBP/ERBB3	4
GO:0001098	basal transcription machinery binding	1/274	70/18367	0.651503818117545	0.747671741373981	BRD4	1
GO:0001099	basal RNA polymerase II transcription machinery binding	1/274	70/18367	0.651503818117545	0.747671741373981	BRD4	1
GO:0004857	enzyme inhibitor activity	1/274	70/18367	0.651503818117545	0.747671741373981	FAF2	1
GO:0004860	protein kinase inhibitor activity	1/274	70/18367	0.651503818117545	0.747671741373981	CDKN1C	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1/274	71/18367	0.656722594629312	0.752097245301618	TGM2	1
GO:0005506	iron ion binding	2/274	151/18367	0.661520566073031	0.753658261477078	PLOD2/FTL	2
GO:0005525	GTP binding	5/274	377/18367	0.665856677675676	0.753658261477078	GNA12/MOCS1/TGM2/GNA11/IFI44L	5
GO:0005230	extracellular ligand-gated ion channel activity	1/274	73/18367	0.666927692694353	0.753658261477078	GABRE	1
GO:0033293	monocarboxylic acid binding	1/274	73/18367	0.666927692694353	0.753658261477078	NR2F2	1
GO:0070063	RNA polymerase binding	1/274	73/18367	0.666927692694353	0.753658261477078	BRD4	1
GO:0140097	catalytic activity, acting on DNA	3/274	229/18367	0.667115668065827	0.753658261477078	TDG/DNMT1/SMARCA2	3
GO:0061630	ubiquitin protein ligase activity	4/274	304/18367	0.667642916417194	0.753658261477078	RNF43/ZNRF3/MYLIP/SIAH1	4
GO:0019210	kinase inhibitor activity	1/274	74/18367	0.671916312580749	0.75553869471816	CDKN1C	1
GO:0005319	lipid transporter activity	2/274	154/18367	0.672046194033725	0.75553869471816	SLC27A2/SLC2A1	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	2/274	156/18367	0.678915335430321	0.76170988853158	DNMT1/PRMT5	2
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	4/274	310/18367	0.682490365892831	0.76416771191246	NFE2L3/PEG3/GATA3/TFAP2C	4
GO:0005125	cytokine activity	3/274	235/18367	0.684082625979394	0.764400019313007	BMP7/CMTM8/FAM3B	3
GO:0016853	isomerase activity	2/274	158/18367	0.68566710049216	0.764622706003379	P4HB/ISYNA1	2
GO:0001217	DNA-binding transcription repressor activity	4/274	313/18367	0.689738641397225	0.767612358974331	NFE2L3/PEG3/GATA3/TFAP2C	4
GO:0030971	receptor tyrosine kinase binding	1/274	78/18367	0.691137292095276	0.767621298262761	PTPN14	1
GO:0044389	ubiquitin-like protein ligase binding	4/274	316/18367	0.69686965033106	0.77243382928262	EGFR/FAF2/TRIOBP/ERBB3	4
GO:0008083	growth factor activity	2/274	162/18367	0.698822149994167	0.773045745083728	EFEMP1/BMP7	2
GO:0016874	ligase activity	2/274	165/18367	0.708387366877782	0.782059653033072	SLC27A2/ACSS1	2
GO:0008276	protein methyltransferase activity	1/274	88/18367	0.73442188632734	0.809183395713955	PRMT5	1
GO:0051117	ATPase binding	1/274	89/18367	0.738402870141898	0.811948972745672	EGFR	1
GO:0016410	N-acyltransferase activity	1/274	94/18367	0.757433392384319	0.830084467403755	TGM2	1
GO:0003735	structural constituent of ribosome	2/274	182/18367	0.757903209368645	0.830084467403755	RPS21/MRPL10	2
GO:0008170	N-methyltransferase activity	1/274	97/18367	0.768182884725886	0.839677133403344	PRMT5	1
GO:0005126	cytokine receptor binding	3/274	271/18367	0.772464956979869	0.842689043978039	GATA3/LIFR/TGFBR3	3
GO:0005216	ion channel activity	5/274	432/18367	0.77547294684677	0.844301906626069	GABRE/CLDN4/FXYD3/KCNN4/ITGAV	5
GO:0030295	protein kinase activator activity	1/274	101/18367	0.781780742415514	0.849494035065676	ERBB3	1
GO:0019209	kinase activator activity	1/274	107/18367	0.800701708264602	0.866641848945217	ERBB3	1
GO:0051087	chaperone binding	1/274	107/18367	0.800701708264602	0.866641848945217	LRP2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	1/274	109/18367	0.806638126374551	0.871358602267617	SLC26A2	1
GO:0019887	protein kinase regulator activity	2/274	204/18367	0.811090264188085	0.873914655258304	CDKN1C/ERBB3	2
GO:0008094	ATP-dependent activity, acting on DNA	1/274	111/18367	0.812398344943135	0.873914655258304	SMARCA2	1
GO:0015631	tubulin binding	4/274	375/18367	0.813753863773131	0.873914655258304	DAG1/GJA1/CLIP1/HOOK1	4
GO:0003774	cytoskeletal motor activity	1/274	114/18367	0.820719656061958	0.879683980866409	MYH10	1
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	3/274	299/18367	0.826354828659107	0.884007491123696	ISL1/TACC2/TAF11	3
GO:0008168	methyltransferase activity	2/274	214/18367	0.831638113824957	0.886794031924342	DNMT1/PRMT5	2
GO:0004197	cysteine-type endopeptidase activity	1/274	119/18367	0.83377917132017	0.886794031924342	CTSL	1
GO:0005262	calcium channel activity	1/274	119/18367	0.83377917132017	0.886794031924342	ITGAV	1
GO:0005267	potassium channel activity	1/274	121/18367	0.838733555701498	0.890347928360052	KCNN4	1
GO:0005179	hormone activity	1/274	122/18367	0.84115529228693	0.891204839428763	FBN1	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1/274	124/18367	0.845890596348013	0.893723405145755	HSD17B1	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1/274	125/18367	0.848205236297618	0.893723405145755	TGM2	1
GO:0005085	guanyl-nucleotide exchange factor activity	2/274	223/18367	0.848389609232565	0.893723405145755	NET1/ADRB1	2
GO:0009055	electron transfer activity	1/274	126/18367	0.850485236585659	0.894010037365368	GLDC	1
GO:0016741	transferase activity, transferring one-carbon groups	2/274	225/18367	0.851900868938738	0.894010037365368	DNMT1/PRMT5	2
GO:0004519	endonuclease activity	1/274	129/18367	0.857122526502927	0.897782987911984	N4BP2	1
GO:0016779	nucleotidyltransferase activity	1/274	132/18367	0.86346620010594	0.902714663747119	CDS1	1
GO:0019207	kinase regulator activity	2/274	233/18367	0.865218572925647	0.902836771748502	CDKN1C/ERBB3	2
GO:0015085	calcium ion transmembrane transporter activity	1/274	135/18367	0.869529200737279	0.905622865673543	ITGAV	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	1/274	136/18367	0.871489983920582	0.905955689499362	HSD17B1	1
GO:0003924	GTPase activity	3/274	337/18367	0.881807737898099	0.911864792617433	GNA12/RASA1/GNA11	3
GO:0015276	ligand-gated ion channel activity	1/274	143/18367	0.884417420134825	0.911864792617433	GABRE	1
GO:0022834	ligand-gated channel activity	1/274	143/18367	0.884417420134825	0.911864792617433	GABRE	1
GO:0022843	voltage-gated cation channel activity	1/274	143/18367	0.884417420134825	0.911864792617433	ITGAV	1
GO:0022836	gated channel activity	3/274	340/18367	0.885433929063304	0.911864792617433	GABRE/KCNN4/ITGAV	3
GO:0008528	G protein-coupled peptide receptor activity	1/274	147/18367	0.891213955549337	0.916108200117755	LGR5	1
GO:0043021	ribonucleoprotein complex binding	1/274	149/18367	0.894461381893649	0.917737328634376	PRMT5	1
GO:0001653	peptide receptor activity	1/274	153/18367	0.90066930587552	0.922392313252852	LGR5	1
GO:0015079	potassium ion transmembrane transporter activity	1/274	155/18367	0.903635445253238	0.923488094883899	KCNN4	1
GO:0004386	helicase activity	1/274	156/18367	0.905085252413386	0.923488094883899	SMARCA2	1
GO:0008017	microtubule binding	2/274	271/18367	0.914700289454191	0.931576678558512	CLIP1/HOOK1	2
GO:0003823	antigen binding	1/274	171/18367	0.924397591298754	0.939719098336855	DHCR24	1
GO:0015399	primary active transmembrane transporter activity	1/274	181/18367	0.935043195125084	0.948793830347512	SLC26A2	1
GO:0008234	cysteine-type peptidase activity	1/274	190/18367	0.94334039483294	0.95545669348217	CTSL	1
GO:0005244	voltage-gated ion channel activity	1/274	201/18367	0.952060547123062	0.960763111539178	ITGAV	1
GO:0022832	voltage-gated channel activity	1/274	201/18367	0.952060547123062	0.960763111539178	ITGAV	1
GO:0004518	nuclease activity	1/274	210/18367	0.958190391028387	0.965184481473849	N4BP2	1
GO:0005261	cation channel activity	2/274	335/18367	0.961704476030373	0.966959691746386	KCNN4/ITGAV	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	1/274	222/18367	0.965165682695667	0.968675376087287	TGM2	1
GO:0016746	acyltransferase activity	1/274	250/18367	0.97725734560002	0.979030952397842	TGM2	1
GO:0016887	ATP hydrolysis activity	1/274	272/18367	0.98373885751038	0.98373885751038	PFN2	1